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<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY03</accession>
    <name>A0A7W7SY03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YjbI with pentapeptide repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21753" checksum="7E715C959A2DF47B" modified="2021-06-02" version="1">MDIIGEGRDDAEYDEDYTDAVLYGQEWEGRSFVRCDFSDADLRGLVTVGCTFTECVFDRADLGESAHRTSAFRSCRFERAVLSSASFTSCTLLGSVFVECGMRPVTFEETDLTLVGWTGARLPGIDLRGARLREANLAGADLSGANLSGAELTGARLLETNLKGADLRGARLDARTLIGADLAGARVDLDTAVAFAAAHGLQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS8</accession>
    <name>A0A7W7SYS8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="31718" checksum="A5EF5309E488F065" modified="2021-06-02" version="1">MTDCLARRFEEHRTHLKAVAYRMLGSLTDADDAVQEAWLRLDRTGTAEIDNLGGWLTTVVGRVCLDMLRARRLRREDPLDARLPDPVVDDDDGADPEHRALVADAVGLALLVVLESLNPAERLAFVLHDLFGLPFEQIAPIMDRTPVATRKLASRARRRVRGATPVPDPDPAARRRVVDAFLAAARGGDLTALMAVLDPDVTLRADGGKALPGGMMVLHGADAVAGRLATFHRMATSTTTRHALVNGTAGLVNTAAGELVSIMSFTIAEGRIVSIDILSDPHRLAELDLSDPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV2</accession>
    <name>A0A7W7SYV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="32749" checksum="2EBD54F668FC3DA9" modified="2021-06-02" version="1">MTAITVSGLRKAFGDKVVLDGIDLDVPQGTIFSLLGPNGAGKTTTVNVLTTLTKADAGTARVAGHDIATDTRAVRAAIGVTGQFAAVDDLLTGQENLRLVADLKRLPDGKRVVGELLERFDLVEAARKPVSTYSGGMRRKLDLAMTLVGGPRIIFLDEPTTGLDPRSRRTMWEIVRGLVADGVTIFLTTQYLEEADRLADRVAVLDGGRLVAQGTPAELKRLVPGGHVRLRFATAAELDAAATLFTESTKDCEALTLDVPGDGGTKPLRALLDRLAEHSLDAVEFSVHTPDLDDVFLALTGRTAEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU6</accession>
    <name>A0A7W7SZU6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ElaA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15935" checksum="CAFF8FB69C0BB714" modified="2021-06-02" version="1">MADLRVAGANALGAAELYELLRLRVDVFVVEQECAYPELDGRDLEPGTRHFWVHDGVPVAYLRTLAEPDGTVRIGRVCTAKQARGLGHGRRLMVAALDEVGVRTCVLDAQTYVVDFYASFGFMVEGDEFIEDGIPHRRMRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ7</accession>
    <name>A0A7W7SZZ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="14">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_001432</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4964073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20904" checksum="254F260BA3F53F70" modified="2021-06-02" version="1">MTEPARVPVWNIANVLTMSRLVLVPVFLYLLLGHDGTDRWWRLAACAVFAVASVTDHVDGNLARKHGLITDFGKIADPIADKALTGAALVGLSLLGELPWWVTVVIAVREMGVTLLRFWVIRHGVIPASRGGKAKTLVQILAIGLYLLPLPANLEIVATISMGVAVVLTVVTGVDYVVRAFRLRARARRAVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T047</accession>
    <name>A0A7W7T047_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisD</name>
        <name evidence="16" type="ORF">F4559_001507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 15">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 14" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4964148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="438" mass="45891" checksum="B6D355611595FA48" modified="2021-06-02" version="1">MLNRVDLRGRVPSPAELRAALPRAEVDVDTVLHQVRPIVEAVRDRGVEAALEYTERFDRVRPESVRVPVTELGAALEALDPEVREALEESITRARRVHADQRRTDVTTQVVPGGTVTERWVPVARVGLYAPGGLAVYPSSVVMNVVPAQIAGVESLVVCSPPQAEFGGRPHPTILAAAALLGVTEVWAVGGAVAVSLLAHGGVDTDGSELAPVDLVTGPGNIYLTAAKRLLRGLIGIDSEAGPTEIAILADDTADAGHVAADLISQAEHDPLAASVLVTTSEELADAVDTELDRRSAATKHAERVRTALRGRQSGTVLVSTVDDGLRVVDAYAAEHLEIQTADARTVAARVRAAGAVFVGAHSPVSLGDYCAGSNHVLPTGGCARHSSGLSVQTFLRGIHVVDYSEDALREVAAKVVALANAEDLPAHGEAVTARFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S4</accession>
    <name>A0A7W7T1S4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalt transporter subunit CbtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6691" checksum="18FB6917C53478DA" modified="2021-06-02" version="1">MTSAAPTLSTPVAVPKWAYAVALVALMATWIVLQENGLALGHAAETIHEFFHDGRHALGVPCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S7</accession>
    <name>A0A7W7T1S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S cluster assembly ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="27491" checksum="270280DEA9A87207" modified="2021-06-02" version="1">MATLEIKDLHVSVTTDEASKEILKGVDLTIKAGETHAIMGPNGSGKSTLSYAIAGHPKYEITSGSVLLDGEDVLEMSVDERARAGIFLAMQYPVEVPGVSMSNFLRTAATAVRGEAPALRHWVKEVKGAMADLDIDPAFAERSVNEGFSGGEKKRHEILQLGLLQPKIAILDETDSGLDVDALRVVSEGVNRYKASGEAGVLLITHYTRILKYISPDFVHVFAGGRVVESGGPELAERLEAEGYVKYTGKPEVAGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y7</accession>
    <name>A0A7W7T1Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="38797" checksum="1379B4B9CCB13FCA" modified="2021-06-02" version="1">MAQVLDYSAGIPGGAAIKAAGYAGAVRYIGLPGYTKSTTRSELDDFTAHGLGMALVFEHLASDWRGGYLAGSENYRRARQHATAIGFPADRPIYMAVDQDVVTNAEFGVALAYIRGARDAAGGDPGLVGVYGEYDVCAAVAAWRGPTGDRLCDWYWQCRAWSGTPVRLLDARHLYQRVGTVTVGGVDCDINDVLQDDWGQHLEDSVGVNDSLGEVTVGGNTFSLTLAKAVKELYLGAYEGGGDAGRLPAYIAANTAAAAWDTPLDNRYGGQVTAKTMLAYIDQHVNDVRAEQAAQREILAQLAQHPDITPERLEQVVRDAVQAANTAHLAEVTAVVREIVGARDENLADEVVDEIGRRTARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T288</accession>
    <name>A0A7W7T288_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N,N-dimethylformamidase</fullName>
            <ecNumber evidence="1">3.5.1.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.56" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050116">
        <property type="term" value="F:N,N-dimethylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="715" mass="76379" checksum="EABAC5B706797CC9" modified="2021-06-02" version="1">MTAVDHTHAKVVGYTDRLSVRPGDRLAVHASATVPDARVRVVRLGHDGTAPTRTPVAVEAPERVAIPHQDFDHGSYGLVPRPPAPGAEVTFAVWVWPTADPGGRVGLLSQGDADEGPHVELALLPDRTVRFAVRAENGVVEVEGPALHLRRWYLLVGGYGPDGLRLEVRPGARVTGEETSSVATAPGAGALVGGQVPLLLGARFVDGDRVGHFDGKLDGPTVFGTALIDVDEHFRDTATAWQRGAKAHWDLFQDIGGDKLLDVIGGHHGTLHNQPLRGVTGHDWTGEVLDWRFADRGYAAVHFHSDDLSDCGWEPLFTVEVPEGLPTGVYAVELATDEGVDRLPFFVRPAARQARLALLIPTLSYLAYALDHLYQPGMPEDPAEYAAPFARANSLHSMYDRHSDGSGVATASLLRPLLGMRDDHVLRATGCVHQLSEDLFLVGWLDRQGVEYDILTDHDLDAEGATAFEGYSAVITGSHPEYWSRRMLDGIGAHLDGGGHLGYLGGNGAYWVTAIHPERRHLAELRRGYVGVRCWESEPGELTLTSTAEPGGLWQERGRAPHRLFGIGTAAAGLTTGGAYEIQDVDHPFLDGIDRTKPLGAFGAVLGGAASFETCGIDALLGSPPGVTLLARAMLGGMYISGDTGPAIPHPLGDPVDRRRSDMTVYTTTGGGEVFSTGSIGWCGALSYDGDDNDVSRLTANVLRSWGVGPAKEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L1</accession>
    <name>A0A7W7T2L1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17243" checksum="E26C6A60F57496AE" modified="2021-06-02" version="1">MSGWAEFGERFAETLREVTDRVFLVVFLQTDPKVYVQFAGEKHELHAQAAGPEVVPWADFGGMVEAGWAAPSGFDPPNWTFALPLPAADADYSAPAARCVVALRDAFALSGPDGLVYKAWRDGEWPLAGETWSPERIASRDVGENPLVLSRLGLPSVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X0</accession>
    <name>A0A7W7T2X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18149" checksum="12A172DA88E46C67" modified="2021-06-02" version="1">MPGDRVDVAGPVRPWCAAVLPVVRRDGYASAHLDELFESYDESYSVGLGFQCLDELVRAYRPWCVEVRAMYVAVTGMGEVLDLDAPGAAGIAAAWDGFTPPEPYLVRRAPDLVPYVVEEYRRPYPAGTFPAPHGVYHGYYRCHRQDDTVEFTSGVYVEHYPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y8</accession>
    <name>A0A7W7T2Y8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="43305" checksum="F9520265F1AF306D" modified="2021-06-02" version="1">MGVLRESLAVEAAQQPQWSTRERLDAVVDELRRRPPLVDAESCHALAAELEFVARGESFVVQVGECAELFADSSRARIQAKAAQVHGLCEIVEAVGLPTVRIGRFAGQYGKPRSSDTETLPDGTALPVYRGDAVNDLAPTASARRADPLRLLAAYDHAASGLNALFMRQLLLPGNSGLSAMLAPTYISHEALLLDFERALVRPDPVRGGEYASSAHMVWIGERTRQLDHAHLAFAAAIGNPVGVKIGPTARPEDVVAIVDRLAAGRRPGRLCLIVRMGVDAIADRLPHLVTALGESARDVVWLSDPMHGNTVRTNAGRKTRVVSDVLREVERFCAVLRRHGCHPGGVHLEATPDPVSECLATRADLASGAEPDRFESACDPRLNGEQAEQVVRHVAELLCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T301</accession>
    <name>A0A7W7T301_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like putative cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="40"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26313" checksum="1A0EF226AD585027" modified="2021-06-02" version="1">MTSVLVTPWWRRRAESARDATGGVDATGVLDWTAPAVAALLARIGAHPPVESLRAAHRLIAADVRPVYAVDDLQPISRTLRRGRGSCSQRMAVLEGVARALGIATRVRGLVVDGRFWYPRFPRLRFLVPDRVLLAWPEFALPSGWTSVGELFGGLGDLASSGRGFTNAGGETLFDAVAHTAVDWDGMTCGSSCDLSATVLGDLGRFDSRDALFRTHGQTLCPPLTLLADPVLSRWAPPATRRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T329</accession>
    <name>A0A7W7T329_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug efflux pump subunit AcrA (Membrane-fusion protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="25366" checksum="DA39E80F36052292" modified="2021-06-02" version="1">MKFRKRALESLESPEQLDEVARLAPVPAWLTALALTLVVVAAGAWSVFGTVPKTVSASGVLTRASGVSTVDATRAGLVTGVLARSGERLEKGQALYELTDDGGTVTVGSPWTAYVVGTLVSPGQWVETGTGVANLERLDTPDDRVRAVVYVAASAARSVRAGMRVELTGVPGAGVVREVGSFPETADSLRAFLGRTRDVTPFLAGGPVVAVIVEPTGDLARSQGVVTARITIADERPVDWLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T364</accession>
    <name>A0A7W7T364_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031498588" evidence="2">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16543" checksum="B4290B816075CF2E" modified="2021-06-02" version="1">MRTLLLLLLLLRFALHKKSPKPGPPPGGPRQPGKPSRQHGAVDAGAGMTSAQRATRDLEQEARPTGVTSDRDVHGRMRTGQRQVDVDHVWQNGEMYIQGDGQIVKVLPNGDGNTYSVVVRDMSNPSGAPTTVLDALTESQLQSRIDRGWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T389</accession>
    <name>A0A7W7T389_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding beta-propeller fold protein YncE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031402163" evidence="3">
        <location>
            <begin position="24"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35835" checksum="D558C23C5DA3EC11" modified="2021-06-02" version="1">MRRGVVVAGIVAGLVVAGLVVRGAPPSVPSVGPADRTTERVLRPWGELPADARPGSGVAVTGSGDVVFLHRAGGDFASDTVIDTDPLLVLTPDGVVRTRLGAGKFKSPHGVSVDAEGRIWVTDVMTNRVTAFNGPTLGHDYGPGLDTCLSIRNELTNLPCTGDPEIFARPTDVAVSSDRHAFVADGYRNSRVAVFDDDRFALEWGGLGDRPGEFHLPHGIALRKNGDVVVADRRNARVQVFAPDGRHRATYASAAIGRPYDVAVGPDDALYVLDGGDALDEDGGGHRGYVVSMDDNGSVKDRWRLADQNADPHQLAVGPRGELYVAALNGPPLYRWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3B4</accession>
    <name>A0A7W7T3B4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030551509" evidence="2">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9232" checksum="8B3B40FD6C36CBB6" modified="2021-06-02" version="1">MRRLFWFGIGLALGVVATRKVNQAAHAATPAGIGENVGEGLRALAGALGEFGADVRAGMAEREHELRDDVQRRTGHTPGRRARGAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G6</accession>
    <name>A0A7W7T3G6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YbjT (DUF2867 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29980" checksum="4A0F052A036DB04B" modified="2021-06-02" version="1">MSEQPILVTGATGKSGRRVVSRLRDKGLPVRAAARGGEYFFDWNDADSWDGALEGVHALYLMPLDGMRLVQPFVERAARHGVRRIVLASGRSVDVPGYVKDTAMMTRFLDGEAAVRESGLEWTISRPGWFSQNFSEGFFAADVRSGELRLPGGDGAVTYIDVDDIADVVVAALTEDGHSGEIYDLSGDEALTLHEVAATISEHAGREVRYVPITVERYVEELLARGWPADFADVIEPLREGRDEHVSDGVGRALGRKPRTFAEFAATTAAQGGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S0</accession>
    <name>A0A7W7T3S0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Neutral metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_003320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Extracellular zinc metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023612">
        <property type="entry name" value="Peptidase_M4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00730">
        <property type="entry name" value="THERMOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031597019" description="Neutral metalloproteinase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="12">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="10">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="11">
        <location>
            <begin position="311"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623612-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4965961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="486" mass="51345" checksum="0BD84340BAA97911" modified="2021-06-02" version="1">MKRHLGYAAALAAIALVAANSPTATAAPASLAQQLSLGSQERLVVVDVVPGADGSEHVRYDRTYRGLPVVGGDLVVHRARDGKVKDVVRATDAKLDLKTTTPAFTAAGGRLVVFAVDRTPTLAWETVTTGVKADQTPTELHVYTDAATGAELLRYDAVMHVEGSGVSTYSGTVALETTQSGSTYQLKDPKRGNQQVNNLNNSTSGGTLFTDADNKWGNGKPSDKATAGVDAAYGAAQTWDYYKAVHGRNGIRNDGVGALSKVHYGNNYVNAFWTDSCFCMTYGDGSGNSKPLTSLDVAAHEMTHGVTSVTARLVYSGESGGLNEATSDIFAAAVEFAGNNPADVGDYLVGEKVDIRNNGTPLRYMDKPSKDGSSHDNWSTNTARVDVHYSSGVGNHFFYLLSEGSGAKTINGVSYNSPTSDGQSVTGIGRDKAEKIWYRALTTKFTSTTKYSNARTGTLAAASELYGANSAEYAAVNRAWVAVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W9</accession>
    <name>A0A7W7T3W9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="35638" checksum="F59337E87903833A" modified="2021-06-02" version="1">MTTFGFNTRVSFGDDEGPAQGLRDGIALFKTAEDLGFASGWVYQRHFDHYLSSPLPFLAAVGRETSRIGLGTAVLPLRYQEPILLAEAAATTDLLVDGRLHLAVSTGSNAPFDAIFGAVPTDARTEAERRQRRFLSAVSGQVLHTVDGPGQGAPVGTGLRATPHSPGLRGRVRQGAASLGSAVRAAELGLGLITGTVLHGLADGETFGAYQARIIRAYRTTWRAVRGTEPPPVAVAASILPGTTAQLRATYADYDHQRRTEGMAASRPRGALPPVVTADLPTGMRISPVFHGTPDEVTEAVRTDPGLAEADEIVLFLPPAFGLAADVRLLADVAAAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T405</accession>
    <name>A0A7W7T405_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="7166" checksum="3212948A1D4CBC28" modified="2021-06-02" version="1">MTTDEPTPRFESGEDTTGQMREESDGLPENQLRWIAEFLAKLEKTRFFDEAKARDIRTMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T482</accession>
    <name>A0A7W7T482_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7424" checksum="695F41D6B826CFAF" modified="2021-06-02" version="1">MYYLATALSAFGVVFFAVIVAKIRARLRGLRSQAGRTSARMKDRIGLIRARSAALKVALAQRRTRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z6</accession>
    <name>A0A7W7T4Z6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6621" checksum="CF836DBEA54DAC50" modified="2021-06-02" version="1">MPYEEKGLRVFLVTAVAGYAGYLALAFLDAAHFWIATAIRTSFVLASVTAAAVKPAAYRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T515</accession>
    <name>A0A7W7T515_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031534705" description="LTD domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="21978" checksum="9C134C5006CB404A" modified="2021-06-02" version="1">MRRILGGAVVLAAAATMIAAGVTVASADDSQPLASSSLVVNEVATSGPNGELDEFVEIVNVSSQTVKLAQNFQVRIYNAQNAQYKTILFPANTVLQPSGSVQSVIVLTGPDFSGTIQRGVQVVPYVLDLPAGIPDDGAVLISTNNNARVDGVAFSASVPAIAREGQPARATANLPVVDPTRYVSAARDVLSTDTDDNMLDFSLHTATPGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T535</accession>
    <name>A0A7W7T535_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="27625" checksum="D69AE0F9F73DC188" modified="2021-06-02" version="1">MISTAPLSDDWRRQLVEAFELLLDGPLSRHPVDAVYATFLDGNLIHELEFHRDPAWVRPAALRGAEPVVWDLPLFDEDATAPTLDAAHSIFEVDGRDPAPHPAFHADLAAVAFAPGLVRGADLAVVAERHGVDLADGTWAGRWCVAYARLVSDGTLFDAMRVALALGDGPDGVLPLEAEAGEEWAEALEAVENPALRAHLAYFCTDGEEGLIYAGTDRTGGDILAGAGCEVVAHWEEGQSQVEFTVVRLSDLVAGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T586</accession>
    <name>A0A7W7T586_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division septum initiation protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="30265" checksum="EF55CECCEA5290B7" modified="2021-06-02" version="1">MNEELVPLRTDFDRSWPGFDRDQVRGYVQEIEADLRVLAADRDNAIARAESVAERLAQTRQENQRLRERLTRVCREPVDLEGATERARRVIELANAEAEEILARAEAVARRCVDAAQRDQEAHRRRHQTLLDQLESHRELSHREHRELMERARAEVDKLTRQAEARRRELDRTANRERERVSEDFDLAMSLRRAEALKALSDHVETTRARSARMLREAEERVAVLDRHRDRILDALGATTSVLVDVGPIPRPRAERTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5A0</accession>
    <name>A0A7W7T5A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Quercetin dioxygenase-like cupin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11740" checksum="705454AFB4C6EB62" modified="2021-06-02" version="1">MNNHTTVTAVDALAPELLAEARQHASHRAARTLVSGTSQRATLIALTQGAELAEHDSPPAATLHVITGTVRLHTHDTEWTLDSGHLAVIPPQRHGLAALTDAVVLLTVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5A3</accession>
    <name>A0A7W7T5A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14627" checksum="794DF4F82D4370A8" modified="2021-06-02" version="1">MSTATITGPPPQSTGLDPDAGEDRLLGALVMRAGFGGEVNHRLVQSMLRAPIIAVPRRNSVDWIFLTGPRTPMSQSTIADLIAAKVWWYDDPGSIPFPSTHHEDSRWVQCPEEGAALPEWAALVGAIRRALTGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T623</accession>
    <name>A0A7W7T623_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative repeat protein (TIGR03843 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28829" checksum="676FEE6944DE37FC" modified="2021-06-02" version="1">MLPGDDGAVEFLTRGRIDVEGRLVDASNATLFCRISLDGVEARCVYKPVRGERPLWDFPDGTLAGREVSTYLVSRAAGLDLVPPTVLRPGPFGDGMVQLWVDTVEDGDLVDVVAEDAVPKDWRAVLRAHDDVGEPVVLVHADHPRVRLMAVLDAVVNNADRKGGHVLHGVDGGVYGVDHGICLHVEDKLRTVLWGWLGEPLPDEGVEALHRLRADLPGALGDVLHEHLTRAEVRRLGERVDKLVAASVFPEPSDDRPMIPWPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T638</accession>
    <name>A0A7W7T638_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035348">
        <property type="entry name" value="MoaF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024724">
        <property type="entry name" value="MoaF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10703">
        <property type="entry name" value="MoaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17409">
        <property type="entry name" value="MoaF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="MoaF_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="28396" checksum="6F0551CFC6ADE0D3" modified="2021-06-02" version="1">MTETTLSDTSTWLPLDGLAPGFDENKAPTVGDLSGREFVLAGGFTAKFTEGRVEWAGGVDDCETFLVDEDLYYTQFHPGSKPTEAVSLFLDLRAGRALVVTTTINESGTPRVTQDFAPTTIEGFDVSGEEPAPTLTLVGRRALWVYSKQHAYEHVYLSRHWYTWQCLAGPEKGLADTDENSTWQLRPGIYVFTWREKVIPCASVTVADHRDVHRTRSHGVLFGLDETGTTPTHFTFGAHGRLLSDTIHPEQYDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B8</accession>
    <name>A0A7W7T6B8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="38065" checksum="ABF551B42DDDB488" modified="2021-06-02" version="1">MPGAPRIANSPHFDPAHTAIFRRRATITPEKAAGAIPAPPSEPLVPTTEIPGTSIPGNAPHLTSRHPITHRTPRSRPTPRSGTPAPPHEPGRSRGPLDPARPRTSAILGAHTGATTPLRTKPAAGERLPALTPTSGCRPCPTRATIPTSTSAPHRPEAHHPIPSGPTTSGRAADSASRGFVDVGFVGRLVTADFGACGAVSGLVLVGRPLCHSRVTFVRGAIRSVPVRDFPLSSDRMRTLSPARPDFGSRSDLGPHPGLPSAPAAAFPPDGSPAGTARVFRPTWNVAGRSSFAPVVKFVARVGGPARRSSHRDGTPPTLATGRPDVGGPRAGDHRSRRLRHPRRSFRRPHRGVPCAHRSREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6G9</accession>
    <name>A0A7W7T6G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB-like acyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="48138" checksum="F22B6313D6162365" modified="2021-06-02" version="1">MTSGVGAPTAVGWSGPLGVTLTGEADVQAACGLMHVHGRRFGRPTALEFDYASALGAELAGLGFAAAELGRARWIPVRALTTSVAQAALLAVSPYLAAATADEPVGPFEPGGPPFVSVEGIAFDLDTDDEGAWSRFWTVLGAEHRHVAQGWLTFPHRYETACCPLPPELFALTARTPIVAVEDIAEETGPTVARLARRAVEDLPPYVVSALPTADLTPDPRREARPDAAPLSGIVVVESVRRTRGPVAGLLLGFLGATVVRVEPPGGDPDRAVRPLVDETSARYHAFNRDKRVVELDPGTPAGLLELAELLAGADVFVHDWTSDEAVARSLDPQALDQARPGLVTAYLSGSAGEFPVQARTGVPHTLMTVVDVFGGVVAARAVVEALTWRRRTGQGQYAEASRSAAASRLNARTRLRSASPRTVPVCTDLAALGADPAFAAVLRRDGCLVPVSPWTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6R9</accession>
    <name>A0A7W7T6R9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superfamily II DNA or RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="570" mass="62316" checksum="E51DC2F4D4F9671D" modified="2021-06-02" version="1">MAQPQVASTRPLRAWQRRALTKYLAAKPRDFLAVATPGAGKTTFGLRVAAELLADRTIEAVTIVTPTEHLKHQWAQAAAEAGLAIDSNFRNTNAVTSRDFHGVALTYAQVAAHPTLHRVRTENRKTLVLLDEIHHGGDAKSWGDAIREAFTPAVRRLCLTGTPFRSDDSPIPFVSYEPGPDGVQRSRADHLYGYSDALKDGVVRPVIFLAYSGEASWRTSAGEEFSARLGEPLTQEQNARAWRVALDPTGEWMPSVLKAADQRLTQLRSGGIPDAGGLVIATDQTVAKAYAEILQRVTGHDATLVLSDDPKASGRIAEFAASQERWLIAVRMVSEGVDVPRLAVGVYATSSSTPLFFAQAIGRFVRQRVKGETASVFLPSVPVLLGLASELEQQRDHVLGKPHREKDGWDEELLAQANQVKDEPGEEERAFTALGASAELDQVIYDGSSFGTAAFAGSDEEQEYLGLPGLLEPDQVRALLRQRQEKQLVDAGKRPVAAPVAPAPTRPASVQERLAQLRKELNTLVAMYHHRTKKPHGKIHNQLREYCGGPPTAMASIEQLEERIATLRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T2</accession>
    <name>A0A7W7T6T2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17783" checksum="4B5DFDF6CC1E2B42" modified="2021-06-02" version="1">MSAPGDVTSVDVTVVIRLSAPSGQVVDTASKLAEALRSALDVPDTEVVVDLPLRRIDPPLRVMVDSRRVLHRGVPVELTRLEFDLLHHLCAHPRQVHRRTSLMTSVWGTTSFVDTRTVDVHVRRIRRKLGDAASLITTVRGVGYRVDDPFSVVVEHDALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X2</accession>
    <name>A0A7W7T6X2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quercetin dioxygenase-like cupin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16834" checksum="14888B17DFA0FDF7" modified="2021-06-02" version="1">MEKPLIVRSPEAELLDADPSATVTLLADTATATANRSRFAAGANGAPPHFHTKATELFFVVSGSLDVLLDQEVRTLAEGDFLLVPPGVHHAFGATSGKDADVLFVFTPGIGRFDYYRLLDRVQRGQADPAEIGASQDRFDNHYVDSPTWTRHRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y4</accession>
    <name>A0A7W7T6Y4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phytoene desaturase</fullName>
            <ecNumber evidence="6">1.3.99.26</ecNumber>
            <ecNumber evidence="6">1.3.99.28</ecNumber>
            <ecNumber evidence="6">1.3.99.29</ecNumber>
            <ecNumber evidence="6">1.3.99.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 4">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.99.26" evidence="6"/>
    <dbReference type="EC" id="1.3.99.28" evidence="6"/>
    <dbReference type="EC" id="1.3.99.29" evidence="6"/>
    <dbReference type="EC" id="1.3.99.31" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="53396" checksum="52D986E2E0FDCF88" modified="2021-06-02" version="1">MRAVNGPTDHVVVVGAGLAGLSAALHLLGAGRRVTVVERDDVPGGRAGRLDLDGYPFDTGPTVLTMPELVDEALGAVGETLADRLDLLPVDPAYRARFADGSTLDVHADADAMEAEVRRFAGPREAAGYRALRTWLTDLYRVERDAFLGANFDSPLDLLTPELAKLAALGGFSRLAPAIGRFLRDERLRRVFSFQSLYAGVPPKRALAAYAVIAYMDTIAGVYHPRGGMRALPDALAAAARDAGADLRFGTRVAWLERIGSRVKAVRTAQGERIPCDAVVLTPDLPVSYRLLGHRPRRPLPVTWSPSAVVLHAGTRRRWPELAHHTIFFGRAWDRTFTELTRRGTLMSDPSLLVTAAPDQGLFVLAPVPNLRTGRIDWDRVGPAYRDEVVGTLEARGLTGLDASIEVERLVTPHDWAGMGLAAGTPFSAAHTFAQTGPFRPRNLLSGVDNAVLAGCGTTPGVGVPPVLISGRLAAQRITGVTGATRGRRVAARPARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T758</accession>
    <name>A0A7W7T758_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7288" checksum="431353ADACE55E54" modified="2021-06-02" version="1">MTSTWTWRKSRRSAGNGACVELATRPGTRLTAVRDSKIGDDSPVLAFGPGGMRAFLLMAKDGKLDHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T761</accession>
    <name>A0A7W7T761_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4240 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025334">
        <property type="entry name" value="DUF4240"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14024">
        <property type="entry name" value="DUF4240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4240" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19116" checksum="1AE7BB5ACB8AF1E1" modified="2021-06-02" version="1">MDIDGFWQLVDTARADVPDADEVAARVSALLAALPREEIVAADRVFEELLASSYRTPLWAAAYVVNGGCSDDGFDYFRGWLIVQGRETFERVVADPDALADLPVVREAAEEGDEFDCEEALGIASDAYRAKTGEELPLDPDPPVLPVLEADFDFDDEEEVRERLPRLAALYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G1</accession>
    <name>A0A7W7T7G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29100" checksum="821541EEDC25EC3D" modified="2021-06-02" version="1">MSDPWGDSVRELLYTDFDGQSVDDPDEVINAAFDDGRYVARVAPLTDLLAAPEASAYDRFLACCALTTWGEPAGYQAVVDAAASPGEVVWRDELIDRKYSVDETFAHLAHAVGASEDFAVAKGTEPARLTALRALLRVSDTEYFDWRLAHALDARVLPFVADDVASAVRQGIHTLTEGPRPSFDLAAQSADLAAAVTPYDERLAVALGGDLMRVDTSPSVLLRLVAIVARGTGPVSLRYADYLASVANDEVRCALSDALARRARESSTQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K3</accession>
    <name>A0A7W7T7K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="237" mass="25521" checksum="A6577A257BCA58CD" modified="2021-06-02" version="1">MPKVVVVVPTYNERENLPVLVGQLLALDVHVLVVDDNSPDGTGEVADKLVADAPGRVGVLHRTAKDGLGRAYVAGMTRALDEGADVVIQMDADLSHPVSVIPLMVSTVLESDVVLGSRYVTGGSTAAEWPWHRKALSAWANFYVNAVLRLGVRDATAGFKAWRASALRAIDLGSVRSNGYSFQVEMNHRAVRAGLRIAEVPIRFEERTEGASKMSLGVQVESALTPWKLLLGRGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Q9</accession>
    <name>A0A7W7T7Q9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (TIGR04222 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="28104" checksum="679F6206B69CB784" modified="2021-06-02" version="1">MTVTAGPARLWPEEQGFLAGGPGRAAEVAVVSLLDAGALRLSRSGVVRPVSGPPRSWTPIQSAALRSASRPFGELVQAVAASAEARGLRRHLLDRGLLVSPTRRALAKTTRVLALLVGIAALLTVLITHVQVLLCIGVVVAMLFVRYFAGKLRGPLTGRGRAEVRDLARYATPASRLHLVAYKGLLGRVGSLRVCDLLGLAPAASTLRRRSKKRSTTTSSSDSCGGGVYSSCGSCAGSGCGSSSDSSSSDSSSSSDSGSSCSSGSSCGSSCGGGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T1</accession>
    <name>A0A7W7T7T1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vancomycin permeability regulator SanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="49"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="24468" checksum="2F5F71E26583803F" modified="2021-06-02" version="1">MRLFRKVRWKRVLLVAGLVALIGTVPYAWVLISSAPYRFKAEDVPETPVALVLGAGLRDGRPTPFLAGRLDVAADLFRRGKVKVLLVSGDNSTVDYDEPGAMRRYLVEHGVPERFIVADYAGLDTWDSCTRAKRIFGVDRLTVVSQVTHLPRAVTLCRRAGVDAYGVGHETWDDYRGTTVQQYVRESVAAYKALWEGVVVRRDPKFLGPQEPGVIQALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T8</accession>
    <name>A0A7W7T7T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn ribbon nucleic-acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6315" checksum="F0242925950AE812" modified="2021-06-02" version="1">MTTTLTRPALTAADRCDRCGAAAQVRAILPSGGELLFCGHHAREHNSKLRELAAELQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W4</accession>
    <name>A0A7W7T7W4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="25977" checksum="AAF6F8C4E21035B0" modified="2021-06-02" version="1">MTNALRAALSAARSAGLPTDDPIVLKNGSNLLVHLRPAPVVARVGTRTAFVRGDVTGHFGRADAISRYLAARGVPVVVPADVPGPVRQDGFVVAFASHVVHTPWEANEASFAALLRELHAELVDYPGDLPERGPLDDLDATLDLLGRPAALVAERDDLVARWPSSPVRPLHGDAHARNVLATTDGPVWNDFEDAWRGPAGWDVACAHLSPALFPDEDVAFWRALRDLFGRCWVASGELYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z3</accession>
    <name>A0A7W7T7Z3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase / fumarate reductase flavoprotein subunit</fullName>
            <ecNumber evidence="6">1.3.5.1</ecNumber>
            <ecNumber evidence="6">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="6"/>
    <dbReference type="EC" id="1.3.5.4" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="484"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="623" mass="68006" checksum="5D5A12E0089DED54" modified="2021-06-02" version="1">MPEVERQSFDVLVIGAGGAGLRAAIEAREHGMRTAVLCKSLFGKAHTVMAEGGIAAAMGNANSNDNWQVHFRDTMRGGKFLNDWRMAELHAKEAPDRVWELETYGALFDRTKDGRISQRNFGGHEYPRLAHVGDRTGLELIRTLQQKIVSLQQDDFAETGDHESRLKVFAEFTVTDLVLDGDVVAGAFGYWRESGRFVLFEAPAVVLATGGIGKSFKVTSNSWEYTGDGHALALRAGASLINMEFVQFHPTGMVWPPSVKGILVTESVRGDGGVLRNSDGKRFMFDYIPEVFKDKYAVDETEGDRWYTDPDHNRRPPELLPRDEVARAINAEVKAGRGSPHGGVFLDVSTRLSAEEIVRRLPSMHHQFKELADVDITAQPMEVGPTCHYVMGGVRVDPDTGASSVSGLFAAGEVSGGMHGSNRLGGNSLSDLLVFGRRAGAGAASYVSGLSARPTCSAEAVEEAARVALAPFSGEGGENPYTLHMELQQSMNDLVGIIRRASEMEQALARLEELKARASSVTVEGHRQFNPGWHLALDLRNMLVVSECVARAALLRTESRGGHTREDHPVMAADWRRKLLVCTVSGTSVSVVEQPQIPIRPDLLALFDEAELRKYLTAAELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z9</accession>
    <name>A0A7W7T7Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR03083 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26015" checksum="49A93C56FA42101E" modified="2021-06-02" version="1">MTPFGYEDRCAEIVRQTDLLTAAVSGADAGTPVPTCPGWTLGRLLGHVGSAHRWAEEVVRTRADRRVPGADADEGDAAWLVDGAARLARTLRTSGPDVPVWTPGPPPHRTSFWARRMMHETALHRYDATVAVGGDYALAHVVAADAVDEWIGFSRSAHSRSRSPALAALRDGVIRLEDTEEPVEWLVQTGRRPDASVTVRGTTTDLALALYGRPADLDFVGDAALFHEWQDASAFWIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9E3</accession>
    <name>A0A7W7T9E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="477" mass="51745" checksum="32C57F6CA0640EB1" modified="2021-06-02" version="1">MILRLYRRVNSLNQERLAALLGYDKTYVSMIETGRRTISDVTTRRHIARVLGLPMHVLGVTDNDDADFAAMIQFGDSTIRLAEIARQSGRAVDAVNELWPLVARLEARAAEGRAERDTMILLGQGRAALGVSLGTVLPEERLAAAARWTGKALVVAERLGDPAFLAHALRMHGDELRKADHVGAAVAHLSRSVAVSSDREGQGTAFALLARAAGEQGNPDLFDHAITGYRALLDTGAGRGMLFNPFTFREIGLRGLISTGRAAEAVHAMQSDQRAGTPAAPQWHIIERVTAGQVLLAAQHQDGAAEAFRTALTAAEVHRLPHQVQRTIRAADDAGLTEITTEGRAALQRFNGIAATLSGLNVALTFFILRAALGQLDVLHQDMNNQEARHREALQAQEQRRVEEEEQAQTELTRQEKRHADESGRAQAQLANAQAQLALQANSVQIAQASAMQAQREAARTRLDFTAPAVRSNSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G9</accession>
    <name>A0A7W7T9G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030697137" evidence="1">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10482" checksum="04788D17D5EF81D6" modified="2021-06-02" version="1">MTPSRVAFAALVLLTISNQPSAVTIGAAGLSVLVAVHAVLYVTHPFTRCRTCTGSGKRRSGLVRAYRYCPRCGGTGLRLRAGRRVWIAITRNRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I4</accession>
    <name>A0A7W7T9I4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ORF">F4559_006412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="34"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32875" checksum="BB4FAD7F4C91B97E" modified="2021-06-02" version="1">MSPRELVVLGTASQVPTRTRNHNGYFLRWDDEGFLFDPGEGTQRQMLRAGVAASDVTRLFVTHFHGDHCLGVPGVVQRLSLDNAPHPVFAHYPESGAEFFSRLRHATAFHDVVDLREVPVRSAGVIATGKFGTLEARALDHSLPSFGYRLVEPDGRTMIPELLERHGVRGPAVRSLTPPLLDRVSVVRPGQRFAFVMDTRLCDGVYELADGADMLVIESTYLHVDEALAQAHGHLTARQAASAAQECGVRTLVLTHFSQRYSDPAAFFTEAAEVFDGEIVVAADLQRVGVPRRRTAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P9</accession>
    <name>A0A7W7T9P9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8853" checksum="28CFD041BC3D817F" modified="2021-06-02" version="1">MALSDRLRAVFVESLGLSDDVDVENLKYRDIDEWDSVGHMALVAAIEDEFDVEFETDQVIDMSSFKVAVDQLRGLGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9X1</accession>
    <name>A0A7W7T9X1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="54"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33466" checksum="141DDF6C7922EE3F" modified="2021-06-02" version="1">MTAPARLDGRFTTDVLTAVLERLCAGLGLDHRGARLVKLTANAVFDLPAERVHVRIVGSMGLQHRAPKVVAVARWLAAHGVPAVRLVEEVPQPLVVGDHVATVWHTVPVTGRAVDGRDLGRLLLRMHSLPPPDVPLPRWAPLDDVRHRIADAEELTATDRVFLEERCAELAFRLDAYRPELPLGVVHGDAHLGNLIPGVDGPVLCDFDSTGVGPREWDLSTLPIGVARFGHPARWYRQLSRVYGFDVTRSPGYALLRDVRELKLTTSALPILRSHPDVGAELRRRLRALRDGDTITPWRPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA06</accession>
    <name>A0A7W7TA06_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ParB family chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="55"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="35288" checksum="4D008F97BFDC6ADE" modified="2021-06-02" version="1">MTEQRKGGLGRGLAALIPSGPPPGTPTPVRVLPRNAPAPTSTAVEGGEVAGAVYQELPVTAIRTNPKQPRQVFDEEALRELEHSIREFGLMQPIVVRETGGDKYELVMGERRWRATQLAGLKTIPAIVRHTADDVMLRDALLENIHRVQLNPLEEAAAYQQLLQEFGVTHEELADRIGRSRPVVTNTIRLLKLPLPVQRRVAAGVLSAGHARALLGLEDPGTQEELATKIVAEGMSVRATEEAVTLAKGAEPAKAKAVRRKPMQAPGLQELAERLSDSFDTRVKVELGQRKGRIVVEFGSVDDLERIIHLMSPDATIRTRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAA4</accession>
    <name>A0A7W7TAA4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13023" checksum="AD0A9C7D8BF523FE" modified="2021-06-02" version="1">MTTWRPADEHESTAGWHLWLSLSTPLWPGPAWDGTAASAMAGLGTVLSACARLECTGPLSDLLHSAVFVGSLPHELWSTDLEPLDGERLALLHADLSGVADHFSHLRTVLATGGGWAELESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB3</accession>
    <name>A0A7W7TAB3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020953">
        <property type="entry name" value="Acyl-CoA_DH_N_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12418">
        <property type="entry name" value="AcylCoA_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcylCoA_DH_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="292"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="476"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="611" mass="66924" checksum="ACD5C425027A68A4" modified="2021-06-02" version="1">MGHYKSNVRDLEFNLFEVFNVQDHLGTGPFEQADEDTARGVLAELDNLATGPLADSFVDADRHPPIFDPATHSVTLPESFKKSYQAIWDGEWYRLSLPEELGGFGIPPTVQWAASELILGANPAVYMYLAGPNFATVIRRNGTAAQQRWAELMVERGWGATMVLTEPDAGSDVGAGRTKAVLQDDGSWHLDGVKRFITSGDQDLTENIMHLVLARPEGPGIESRPGTKGLSLFLVPKWHFDGQTGESTGERNGAFVTNVEHKMGLKVSTTCELTFGQHGVPAKGWLLGDVHDGIAQMFQVIEYARMMVGTKAIGTLSTGYLNALAYAKERVQSADLTRMTDKTAPRVPITHHPDVRRSLMLQKAYAEGLRAVYLYTATFQDKIALGGEGRELAEKVNDLLLPVVKGVGSERAYEQLAQSLQTLGGSGFLQDYPIEQYIRDSKIDSLYEGTTAIQSLDFFFRKIIRDKGQALGFLNNEIQKFLDAPGDERLADARKLLGQALQDLQGMLGAMVGFLTSSQEDVRNLYKVGQNTVRLLLTAGDVLVGWLLLRQAEVAAAKLGGTVSARDKAFYEGKVAVAGFFAKNVLPELTARRKVAETTDNSLMDVDEAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC3</accession>
    <name>A0A7W7TAC3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme related to lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase_6" evidence="1">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13913" checksum="61B8846EBC82685F" modified="2021-06-02" version="1">MTSLVHNITFDTGNPYELASFWSKVVDRPLSDDDKPGDDEAIIALSGGPSLLFLRVPEGKTVKNRVHLDLQPSTTREEEVERLIGLGAKLFDDQRRPDGTGWVVLTDPEGNEFCVERSAAEKAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAN4</accession>
    <name>A0A7W7TAN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase subunit beta/citryl-CoA lyase</fullName>
            <ecNumber evidence="6">4.1.3.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.34" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008816">
        <property type="term" value="F:citryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="32180" checksum="631A8C2FA675C009" modified="2021-06-02" version="1">MVDKARTLPADMVFLDLEDACAPLAKADARKTIVAALNEGGWGARTRVVRVNDWTTEWTYRDVVEVVEGAGAHVDCLLLPKVQTAQQVQALDLLLTQVEKATGLEVGRIGIEAQIENALGLTNVDAIAASSPRLETIVFGPADLMASINMKSLVVGEQPAGYDVGDAYHYILMRILMAARAYDLQAIDGPYLQIRDVAGFRRVAGRSAALGFDGKWVLHPGQIEAANEVFSPRQEDFDRAENILDAYAHFTSEAGGRRGAVMLGDEMIDEASRKMALVISAKGRAAGLVRADVWTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT30</accession>
    <name>A0A7W7WT30_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031352110" evidence="3">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="27"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20855" checksum="13DF8088DACEBB5A" modified="2021-06-02" version="1">MRRLLPVLLLLLTTACATGDDAVVAGAEFQFVAPDGQVRLRYEGDERKPIKGLSGPSLMEEGRTISLSDYEGKVVVVNIWGAWCPPCRTEAPEMQKVQDETGPLGVQVLGLDVKEPSPEPGRDFIRNRKLTYPSIYDESGRTLLAFRGYPPNVVPSTIVLDKRHRVAAVFLEGLIATDLVPLVKELAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTB6</accession>
    <name>A0A7W7WTB6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="100"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="36807" checksum="15D07952FA7A73DC" modified="2021-06-02" version="1">MYQRLDEAVAELRERLGGLPAPAEAEDIWSNIWHQEAHNSTALEGNTLVLQEVERLLDEGRAVGAKPLRDYMEVRGYADAARWVYGQALDPGDWQTGELISLQEVRHVHHLCMTPVWTIDPHPHATDVESPGSFRRHEIAAFPGGMKPPSWTDVDHLMRGWVDETAKLRDLGDEPLPESLARAHNSLEQIHPFLDGNGRAGRLVLNLLLGRLGYPPAIIFKRDRDKYLQAMRRADRREYGPLGELIARSVTANLYKFVIPAVAGPVKLVPLVALATEDLTENALRVASMRGRLRAIKGDDGLWRSSRNWVDEYRQNRHRRLNGPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTJ5</accession>
    <name>A0A7W7WTJ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="30464" checksum="1B342F6F0D3CE301" modified="2021-06-02" version="1">MPEIPPALARLVRELKSLRLRAGQPTIETLASHIRCSRQTVSAVLNGHRLPRWEFVERFAEYCAATPDVVARLHDLWLDVHMGEDEPAVPVPFPGLDSVGVEWFDDHAAFYAAGADGIARTTSQIRTTYVHQHPPTIYRATAAERYFTAILDWARERGERTVRRIVGVRFVGGRPESSMLDWLVAHHAETRDIENYEVRVLPWSPPADGVNLMLFDDAHTFLAFSGQSKAGLSGFRVESEKFQKYFVLYYEQLWAPLESVEKFLGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR8</accession>
    <name>A0A7W7WTR8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26368" checksum="FEC54DD4AC7F987F" modified="2021-06-02" version="1">MSTVALVSGASRGIGAAIARSLAQRAHHVIVNYYRNADAAKQVVADIEAAGGTAQAEQADVCDDASVTALVDRVRAAHGRVDVLVCNANTVPPPFEPLASLPWDAFVGKVVGELAGSYHLTQRVLPIMRERRAGRIIYISSTVADKVGTIAAHSTAKAALNTFSRHVAADAGQYGVTVNTLALGAVDTDATADILDDDRRASLARRSVHGRVLEPADIGAAVALLADDGFGSVTGQVIRLDAGFDVLNQQPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV4</accession>
    <name>A0A7W7WTV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="31445" checksum="4281ABC67B4EFFFC" modified="2021-06-02" version="1">MIRRYVAFELKRLREASGKSQQDAATRIDTSKSRVTHLESGRNMPKLLDIEALLELYGVPEMTEQFKELIVQARESGPVFDLDSTLNLLPGFDMYVGLEQGASRIFTYDAVVVKGILQCRRYAEATIRGHLGGADLADDRVRTLVDLRMRRQTAFERSEHPLEVMAVIGEGVLRQQVGGADVAAEQLEYLLTLAERENITIRVLPFSSGAHPAMQGPFTRLEFPIERDPGVVYLEDLSGGRYRDDTEDIDRYAQVGAHLLDVALPARKSLSVIDTIRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU88</accession>
    <name>A0A7W7WU88_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN phosphatase YigB (HAD superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22353" checksum="EAD7A9BF1903E28C" modified="2021-06-02" version="1">MVFDVGETLVDDSREWGRWADWLGVPCHTLSAVVGAVTVAGLDNAEALGFFRAGFDVGRERRLREEAGVGESIEECDLYPDVREGLGRLRDAGLWVGVAGNQTARAGELLRGLGLPVDAVATSGEWGVPKPDPGFFARVVEMAGCAAGEVVHVGDHRDNDVVAAKAAGLRAVLIRRGPWGHLWADDPLVRRDADGVIDSIHELPELLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU93</accession>
    <name>A0A7W7WU93_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Osmoprotectant transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="24354" checksum="C456411A1AFDA201" modified="2021-06-02" version="1">MIFADAFAWLVDPTNWSGSKSIPVRVGIHLLYCLGGVLGAAVIAVPLGLYVGHTGRGGVLLVGTGNALRALPTLGLVTFLYLVLGGGTAGVLVGLVVLAIPPVLAGAYAGVQGVDRGVVDAARGMGMTGAQRLWKVEVPNALPLLIAGLRNATLQVVATASVAAFIGIETLGRPLLDGLRVLDYGQFVGGAILIAVLAVVLDALLALVGRFVVPRGLRLSAQPKRRRKTASVKVGGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUB1</accession>
    <name>A0A7W7WUB1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">F4559_001459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="38721" checksum="DC8A0195B583B756" modified="2021-06-02" version="1">MKSILIAAAIALIASIMLTPYLIKVFSRQGFGQEIREEGPQSHKTKRGTPTMGGVAILVAMWLGYLGTHLINSMSASAADQTPTASGLLVLMLTTSLGVVGFLDDFIKIRKQRNLGLNKTAKLVGQFIATIAFAILVMQFPNKDGIEPASVNLSFVRDITVVSFGVVGFVVFCYAAVSAWSNAVNLTDGLDGLAGGTSAMVLGTYVVISFWQFRYNCSSSPIAGCYDVRDPLDLAVVAAAAMAGCIGFLWWNAAPAKIFMGDTGSLALGGLVAGLAITTRTELLVIVIGGLFVVEAMSVVLQVAVFRTSRRRLFRMAPFHHHFELAGWAETTVIIRFWLLAGICCMLGLGLFYSEWLTAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ6</accession>
    <name>A0A7W7WUJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10210" checksum="DFF8C50A473BD38C" modified="2021-06-02" version="1">MRWRGVRADAAAALWTGVGRRVSVGSVPGLVIRPTRRLKLREVEPPRPADAPPWWPAVTIHRGAAAAVVRVIAHGWVTVALPPPMTRGGARSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM4</accession>
    <name>A0A7W7WUM4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-zinc-cadmium efflux system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="31523" checksum="FBE55637F5BCD82E" modified="2021-06-02" version="1">MGHGHSHGGASGGARHLGRLWVAFGVGAAFMLVEVVVGVATQSLALISDAAHMVTDVLGVGMALGAILLARRAAVGGGRTFGLYRAEVLAALANALLLFGVAGYVVVEAVARFGDPPEVPGTPVVLAAVAGLAANLVSFFVLRGGAEESINVRGAYLEVLADLIGSVGVLVSGLATLLFGWRYADPIMGVAIGLFVLPRTWKLAAASLRILFQHAPERVDVATMLNDLGALPGVEEAHDLHVWTLTSGMEVASAHLTTRHDADPAEVLEAARTLLAQRYHIEHATLQVEPGHAAVRCREIHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW2</accession>
    <name>A0A7W7WUW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13751" checksum="3EFF70204F2376C3" modified="2021-06-02" version="1">MTLPEQATRTTVGEVWRAVIDGSLGRDEAHRWAARWIEADDAEVLDRMVLSALQRLHGFDLVWTDLARTTVRHGGSEAYVHSASDIRQALTAWQDDCRSYDADPVGHIQRKKAAARAAVQGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV03</accession>
    <name>A0A7W7WV03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030930672" evidence="2">
        <location>
            <begin position="25"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="381"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="503" mass="53022" checksum="1D6DFC8204616567" modified="2021-06-02" version="1">MRATSRFGITAALVLVSSVAASVAASFDLVRGDAAVVLDDLAQLATGLLATTTCLVTARTRAGADRWWRILMGLGMLGWSAGMALWTWYQLVEERAVPSPSLADAGYLSVVPFALAALSVIGNHRRSESPDALLDRRSRTARVVPLLDGVIVVASLFVLTWTTSLGGLVAAGNPDAGAFLVAIAYPITDLVLLVIVVVLGSDRKVVLRPPLLLLGLGLLGLAASDSAFAYLVSIQAPEVPPLANAGFVLGPAVVALAPLVPTGVRTGGSAAADHRRQWTYLSMPYVPLVLCTVLVLRRTLSGEGSGVDAVEIGCGFAVFVAVIVRQLVTIVDNARLAALLRDSELTLAHQAHHDPLTGLANRAVFERRLDEAMAAYHRDGTPFGLLFVDLDDFKAVNDKAGHAHGDVVLERAARLLHDCVRDTDVVARLGGDEFGVLVEGVEEPEKVAFRVLDALGSDISASVGVVICADHDPEATAQSVLRRADTAMYEAKRDGGRGLVIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV39</accession>
    <name>A0A7W7WV39_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="41" mass="4351" checksum="85E1CD1CF463438A" modified="2021-06-02" version="1">MPFGDVDVEHDEAARDQAVVLPDGTVLVEPTDTELATALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB5</accession>
    <name>A0A7W7WVB5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmH family RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="23657" checksum="B9CFFB8438844EE8" modified="2021-06-02" version="1">MREALAWAAAGRGRVYELFVTDDARHAELVRAAVDAGVPVSPVTDRAAAALSETVTPQGVVAVCSPVDVPLEVASRGARLVAVLHGVSDPGNAGTVVRVADAAGADAVLFAGDTVDPHNGKCVRASTGSVFHLPVARSRSADEVFAACRAAGLRLIAADGYAPEDLVTADLRGDLTRPTAWVFGSEAHGLPDEVVASLDASLKVPIYGGAESLNLATAAAVCLYASARAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD3</accession>
    <name>A0A7W7WVD3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="9">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_002295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004319">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="27187" checksum="5652CB65E7F32E38" modified="2021-06-02" version="1">MTGLLEGKRLLITGVITDASIAFHVAKVAQEQGAEVVLTGFGRLSLVELIAKRLPRRAPVVELDVQNQEHLDTLADRVREHVDGLDGVVHAIGYAPPSCLGAPYLEAPWEDVSTAFHVSAYSYKALVAATLPLLGEGASVVGLDFDARQAWPAYNWMGAAKAAFESINRYLAREVGPQGIRVNLVSAGPVRTMAAKSIPGFAELEAMWGEKAPLSWNVDDPAPVAKSVCGLLSDWFPATTGSIVYVDGGVHFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVG8</accession>
    <name>A0A7W7WVG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030673893" evidence="1">
        <location>
            <begin position="34"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20312" checksum="50521F51E3F72C52" modified="2021-06-02" version="1">MGYKRVVKRWVWVVVGLVVLAGCSVPVPGTPVAEGRAIGVKKTYPEAVMLWMANWCGVADYLVASGQTEVAEPAADPAVAKKQLSDQLGRLVDVLDVVLHDLGELTPAPAPAAETAVDIVTEHLTKARDKFAAAKEILDDADRLTDDVFASVTRNLGDATATMAEAVEKMNAITLPPDFVEAGKQTGNCTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH9</accession>
    <name>A0A7W7WVH9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase/UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.35</ecNumber>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="2"/>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="34535" checksum="0DEB8EDDC46B9CE5" modified="2021-06-02" version="1">MKHLVLGGAGFIGLHLTRRLLADGHDVTIVDDFSRGKDDPELAELSVPVVHADLTDPHSLDELPHDADHVHLLAAVVGVRNVERDPAKVVRVNTLAVLNTLDWIEPHQRLFFASTSEAYAGGVHTGLVPVPTPESVPLVIEDITAPRFAYAVSKSLGEAAVVHTGRAKGVRVVVGRFHNVYGARMGADHVVPELSLRAIRGEDPFRVYGSDQFRAFCHVDDAVDAIARLVDADDAAGRIVHIGDDTAETNIGDLTRLILDIAEHKPELERVPAPPGSVARRCPDLTLLRSLTGYEPKVSLEEGVRRTFEWYRDNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM5</accession>
    <name>A0A7W7WVM5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16534" checksum="85DA3D1861E6F5E3" modified="2021-06-02" version="1">MGRLTDQARAQKEAAIRAAMDRLLRGEIPAGGKCDVKTLAHASGITRAALYSTYVHLKEEFERRRDQLRDAGIIADPRDAQIDRLKEQVRHLTKRLEATQQENNDLTAFRTLALSRLAAQHEDILWLRAAASTGNLHDLAAVRDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM9</accession>
    <name>A0A7W7WVM9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002416</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="32818" checksum="A3B7F38BB2B2912A" modified="2021-06-02" version="1">MIVEVRGLRKAYGPKSVLAGIDLDVAEGTVFALLGPNGAGKTTTVRILSTLVRPDAGTVRVAGHDVVRDPVAVRRSISLTGQYAAVDDGQTARENLFVVGRLLHLGRSAARHRAAELLARFDLLDAADRRVGTYSGGMRRRLDLAMGLVGRPRVVFLDEPTTGLDPTGRTTMWAAVRELVATGTTIVLTTQYLEEADRLADRISVVDGGVVVAAGTADELKARVGGDRLDLEFADPHTRDAARRVLGGRPDPDRPALGLLSDGSAGHLHHVLDTLRANAIDPVRVTSHRPTLDDVFRAVTTREEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT3</accession>
    <name>A0A7W7WVT3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20240" checksum="4E8B508F68BD1745" modified="2021-06-02" version="1">MRERAVLLVTGIQAAGKSTVAQLLAERLDDAVHLRGDLFRRMIVTGRADMTPDPSPEAVRQLRLRHRLTADVADAYFEAGFTVVAQDVVLGDHLTDLVTSIRSRPLLVVVLAPSPAAVAAREAGRGKNSYDEWTVNLLDQGLRTETPRIGLWLDTSDQTPEETTTEILARAWTEARISYDHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT7</accession>
    <name>A0A7W7WVT7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4611" checksum="C9D2845C2ED5A915" modified="2021-06-02" version="1">MEEIKPGEYEQPLMVEIGDFAELTNGIGSQNPWDTAWLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW44</accession>
    <name>A0A7W7WW44_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="37882" checksum="4A243E402795CC16" modified="2021-06-02" version="1">MTIAHDDPYVGRLFDRIALLVVDGEGDPAQLHAELVELTLANAPDVARYWKEVGFGTGVPDSAYKDGGPHLFPDAPVVREFRTSGTTGSSRGLVRYTGPGLALKGISVAANARLHISRPGARPAVILFGPAERDAPHMAIAFDMARILETVGDPDLSLAVVGPDGVDYDRLAAHLDLVVAEGRPAVLLGASFGYVNVCDELEARGLRWDLPAGSRMYDGGGFKGRSRVMRVDELRDLVGRVLGVREFDNMFGMTELATQFYDAVDRPVGPLGERPKIGTVWSRMAVRDPATHGHVTAGRGLLEITDLCLIDRPHVLLTGDVALAGADGVALAGRVAGTPSRGCSLSLDEMTAGTVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW86</accession>
    <name>A0A7W7WW86_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19200" checksum="448272DC8CEEE58E" modified="2021-06-02" version="1">MIAWWLRPVRFTGPAERLIPVKVTAARVADVASFLGLAGHVEQWFGPMVDQPGFRDALRRNIDRGTAMCVRPQDGGDLRGGILFTIRPPVCRIGWLVVAPPDRGTGVGRALVTEVVRRLDGSGMVEVITFGEDHPAARPSGARTFYLRLGFAAQEPADPGPDGTSRQWFRRRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW87</accession>
    <name>A0A7W7WW87_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UMF1 family MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="29"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="465" mass="50120" checksum="72ACDB29DBBD9008" modified="2021-06-02" version="1">MSVADGTAPGIDRKREQRGWTWYDWANSVFPTSVALVFLSGYLSAVAEQAARADVVRNGPNACAESRLRDCDISLFGAHFPAGSLWGYLLSLSTVIQVVVLPIMGAIADRSQNKRRMLAVFAFTGSAVTIALALVSGSDWGLGVILFLIGNVCYGASIVVYYAFLPEIADPDERDGVSTRGWAFGYLGGGLALALHLALFLGHDALGLSESTAVRIAFVLSGLWWAGFTLIPLARLGRHREPRPVEAGQSVVSAGFTELRTTLRQARTFPLTLAFLGTYLLYTDGITTVNSVSAQYGREELKFDETVLIATILIVQFVAFFGGLLHGWAARRWGAKNTIMASLCVWIVVITGAFFVQAQQPTQFYALAIGIGIVLGGTNALSRSLFSQMVPPGREAQYFSLYEIGERSTSWLGPLVFAGVGQATGSFRLAIVSLIVFFVVGFVLLIFVPVRRAIIASGNRVPAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA5</accession>
    <name>A0A7W7WWA5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="25626" checksum="D0953757B701A25E" modified="2021-06-02" version="1">MAFVRACGADDDEVDRWVAARRRVVVGLEPEPIEVRDGTASIPEGPDETEPKRSARLKALVAVAVLAVSGTAMAVWWSTDDRNAIPPEGARVLSAPDGKTRVGTLRVEHKYSVYCRLGGSQPWMLTFVHTTEVVGWVDARDLPTADVPDCARAGESAPARTGYLWQQGKPGTTSEHVGDVKLGVGHDENLRWYVFREGEPYPASRETGWYAVVDVGAPEPSVGFVNCSQLVLPCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ8</accession>
    <name>A0A7W7WWQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator YhcF (GntR family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12677" checksum="5233BA48C72EB0A8" modified="2021-06-02" version="1">MISLDPVSTVPPYEQVRSQFARKITDRELAVGTRLPTVRALAAQLGIAVNTVARAYRELEEAGLIETRGRAGTVVSAAGERSRERVLRAARGYATTAREQGLTTEEALEIVRAVLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ4</accession>
    <name>A0A7W7WWZ4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH IS21-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30539" checksum="97216B8D81F7BE59" modified="2021-06-02" version="1">MWRNLCDKVLLEVRAHAGCRATVNPPRPGGVHEQTVRERRDKVHELLDQGVGLLDCTRRLGVALDTVKRYARMPEPHTTRIAPSYRPTLVDPYREHLRARRAADPAIPVTRLLAEIRDLGYTGSANLLVRYLDQGRAEGERPVTTTRHASCLLLAKPENLRPKDTELLEKITAACPEMTTLASLVRGFAVLLKPAAGNDAKLTEWIAEARAVDLPYLRGLTNGLGIDRSAVDAAVTLPCHNGRTEGVNTRTKRIMRQMHGRAGFDLLRHRILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX07</accession>
    <name>A0A7W7WX07_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methanogenic corrinoid protein MtbC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038719">
        <property type="entry name" value="Phycobilisome_asu/bsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="86"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35815" checksum="DCF0EC6EEA3C7F94" modified="2021-06-02" version="1">MTDRDELLDALSAADEDAAVALAERLLDAGVPAENVLIDLVADVQTEVGRLWQTNRWTVAQEHAATAISERVIAVVARRMRVDPTRGHVVVACLDGEWHAVPPRIVAEVLRGRGWRVTFLGASVPTAHLVSYLHEHGPDAVALSCTLSRSLPRADQMITACRATGTPVLVGGRGFGAGGRWARLLGVDAWAPSATAAAELLESPRWQRIAPPLTPRRADPEYAALRTRRAELISAALAALRDAFPPMRTYDERQADATLEDLGHIVDFLGASVYVDDPGVFGEFIAWTGEVLGARGVPVASTAIAMAAMARVLDDHPRALRHLEHGRDVVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX94</accession>
    <name>A0A7W7WX94_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="19340" checksum="C1EFB0C6DC323B1A" modified="2021-06-02" version="1">MRICVYCGSSDASPQFLAAAAAVGRTLAERGIGVVYGGARIGTMGAVADAALAAGGEVVGVIPGFLVDLEIAHTGLTELRVVGTLHERKALMLELSDAVVALPGGTGTLDELFEAWTWAQLGLHDKPVGVLNLDRFYDPLVAMVDGMDTHGFLKPTARDRLLVEDDLDRLLHRIGGHRSPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL7</accession>
    <name>A0A7W7WXL7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23698" checksum="1A5D97CDCD682151" modified="2021-06-02" version="1">MVRVVIAEDSLLLREGLSRLLVEAGVDVVAGVEDGDRLLAEVDRHRPDVAVVDIRMPPTHTDEGLRAALELRRRYPETGVLVLSQYVRVSYAAELLDAGTDGVGYLLKDRVSDVAEFVAAIRRVGSGGSAFDPDVVRHLLGRRRDERDDVLTERERAVLALMAEGRTNQAIAQRLYIAERTVEKHCTAIFAKLGLAASPHDHRRVLAVLRHLNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX7</accession>
    <name>A0A7W7WXX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine protein phosphatase PrpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="23238" checksum="37593FB0DFEF8D13" modified="2021-06-02" version="1">MGAPDVLSEVLESAISATTANLSLVPGRAPSSTVLMVRADRDQLNVLALGDSTVIVSVNGRANRVTDDRLASVGTALRRQYVNRLAAGSGYDDEHARLLRRLQERELVARNVPGGYWIAETNSQAAEEATTRTFHVPDVDWCVLATDGFERPVEHLGIAWSDIARMNGDELSDLLHSLHRWEEHSDPDGFALPRAKRHDDKTVVVWPGPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM9</accession>
    <name>A0A7W7WYM9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31440" checksum="B7CA7A71987BBA9B" modified="2021-06-02" version="1">MSLTPSQFAWIAEMVERAAAIVLAPGKEYLVESRLRRLATQAGFDSIDALVLAAQRNSPPSLRHELVQAMTVNETSWFRDRDPFAALTDVALPEIVRDTPRGPLRIWSAACSSGQEAYSVAILLDKAGMSGRGYEILATDLSEEMVTKTREGRYNQLEVNRGLPASDLVTYFERQGAEWRVNDRLRSHVTTRRLNLAEALPPMQKFDVVFLRNVLIYFNLDTKRAVLNRIRQALKPGGWLLLGAAETTVGIDADFERVPAGRTAIYRVPAGSRQPVKEVTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR7</accession>
    <name>A0A7W7WYR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="172"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="46550" checksum="D4D5279304167C0C" modified="2021-06-02" version="1">MALPELHRFTLPNGLRVVLAPDSSAPVVGVSVHYDVGFRSEPEGRTGFAHLFEHLMFQGSESLEKLAHFRHVQSSGGTFNGSTHPDYTDYYQVLPSAALERALFLEADRMRAPKITEENLRNQIDVVKEEIRLNVLNRPYGGFPWILLPPVLFTTFPNAHNGYGDFVDLENATVDDCAAFFDAYYAPGNAVLTVAGDLDVERTKSLVDKHFGDVPARPVPARPSFAEDAPKGERRAEHTDKLAPMPALALGYRIPDPVTEVEGYLAYLVLAGVLTDGDGSRLQQRLVHGDAIVVDVGAGCGLFGPLEARDPDTFSVTAIHPPDVPVERVIAAVDEELLKLAEHGPTERELAKVTARWVSTMHREHDRLTSRTLGLGSAELLFGRAELLYELPEKLAAVTADAVAAAAKALRADARAVLIVKPADGGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS7</accession>
    <name>A0A7W7WYS7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="2">
        <location>
            <begin position="205"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="35273" checksum="5241CA0BBB81B755" modified="2021-06-02" version="1">MRVVMFGYQTWGHRTLQALLDSEHEVVMVVTHPKSDHAYERIWSDSVADLAAEHGVETLVRERPDDEELLRRLKEVAPDVIVATNWRTWIPPHVFTLPRYGTLNVHDSLLPAYAGFSPLIWALINDEKEVGVTAHMMDETLDAGDIVLQRAVPVGPRDTTADLFAKTLALFGPITVDGLAEIAKGRTDFVKQDRSKASFFHKRSETDLLIDWTWEADELDRLVRAQCAPYPHAFTFHRGRRLEIVEAEVSQAKYGGTPGRIFYREGDGVAIVAGASARRGRNPGLLVKKVRTDDGTELGAAEYFTHMGGYLTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ00</accession>
    <name>A0A7W7WZ00_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5838" checksum="E9816CE6B73406AB" modified="2021-06-02" version="1">MQKWEYATVPLLIHATKAILDQWGEDGWELVTVLTNPTGEQHVAYLKRAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ13</accession>
    <name>A0A7W7WZ13_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NBD/HSP70 family sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="42174" checksum="0F2FC4B66FE26C5E" modified="2021-06-02" version="1">MRAGSPRLLREINDRAAIEALLRNGPLTRSDLEGIIGLSKPATAQLLTRLETDGMVLRNGLRGGGRGPRAQLWTVNGALAHVAAVDLTPDAIDVAVADISGTLLTEHSAPMPRTDVLDAFHAAVRQAAGQAGLTTEALHHVVVGSPGAVDPATGRLVYAPHMPGWSDVDDLPRTLEALLDTGVTVENDVNLVALEEMIAGRATDVRDFVLIWPADAVGAAVVVNGVLLRGATGGAGEIDAMRVPDRAGADTGTTRAGSRYGELLDNAAVVRLARAHGLTARTAQSAVRKAEPSSPFLLDLARRIATGIANVVAVLDPELVLLSGEVAHAGGTALADLVAEQLHRLVVPRTPVQLAMVTGKPVRSGALHSALSVAREQVFGLPAATTEPFRGPRLDQRSAATSPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ27</accession>
    <name>A0A7W7WZ27_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase family protein (TIGR01976 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011340">
        <property type="entry name" value="Cys_dSase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01976">
        <property type="entry name" value="am_tr_V_VC1184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="42"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="43652" checksum="38A0B2787D5F76FF" modified="2021-06-02" version="1">MAHVPGNRVRDPGADPRTVCGMAFDVARVRGLFPALGDGWVHLDAPAGMQVPEQVATAVSTALRAPVSGPGGIFPASQRAEAIVDAARRAVADLVGADPAGVVLGPSSAVLLSRLADAVSDTWFLGDEVVVSRLDHPANIAPWQRAAQRTGSVVRWAEVDIETCELPAWQYDELITDKCKLVAVTAASGSVGTRPDLRKIAEAARRTDALVVVDASAAAPFVPLDITSMNADVVAVSANTWGGPPVGALVFRDPSRLDLLPSVAVEPGARGPERLELGPHAYPLLAGLVASVEYLAGLDDASVGPRRERVLTSLGSVKAYQAGLLANLINELRSLRHVMVIGDAMRRVPALAFTVAGVKAGDCVEHLSERGVCAFADSGQHGVFSVLGVGEVGGAVRVGLAHYTNAVEVDELVRAVAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ67</accession>
    <name>A0A7W7WZ67_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="11067" checksum="D5E515876DB47097" modified="2021-06-02" version="1">METELGLDLAKVKTYTMRELNQNTARVLEEVNDSCRPAAVTKHGRFIALITPLRDLEIEQLVLSRGALGDELDRRAGDSTSDDLSPVEVARRFSDRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB1</accession>
    <name>A0A7W7WZB1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11800" checksum="7620084DDCA83108" modified="2021-06-02" version="1">MSGSTVVVSDKSFTDDVLTSDKPVLVDFWATWCGPCRMVAPVLEEIAAEHSDKITIAKLDIDANPEIAREYKIMSVPTLILFQGGRKVKEIQGAKPKAVLLNELADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC8</accession>
    <name>A0A7W7WZC8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9136" checksum="644932BB50A1C100" modified="2021-06-02" version="1">MTSVGEVKLRLEQGCELLGDVYRCVREAQTALDEALELLAEVDATSGEDLVPAGFVTARERFADELELIVVSQELVRRLSAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZQ8</accession>
    <name>A0A7W7WZQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10862" checksum="A9AAB3E84D757D93" modified="2021-06-02" version="1">MKTRYLDMAGVGRALASPVSRHAVVKWRERYPQGSEHPFPEPDVITGAWDVDPDTGELVDDQDERGVPGWNAERLPEIEAWRARLPGRTGRPRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZS2</accession>
    <name>A0A7W7WZS2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008670">
        <property type="entry name" value="CoA_reduct_LuxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05893">
        <property type="entry name" value="LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="43916" checksum="AF1C7CF82E5F2308" modified="2021-06-02" version="1">MTLVEQRFPAGPSLSVDDLLAEVASGDRLEVGDPRVVEFLVRFARKLLAPAVARRYPELASLGFFLRRGEITKALARLETGSADVLRFPRGLVFHVPPANVDTIFVYSWALSALAGNPNVVRISSRSAGAASTVIDALNEALAEADPVIARTQRMVTYGRDDAVTAALSGACELRVIWGGDASVRTLRQFPLKPSARDVTFPDRASFAAVSVVGWRAATPEQRHDAVVGFYNDSYWFDQAACSSPRTLFWVGDASRAERDEFTTLLASVTAAKNFVVEPAMAVQKRVSAYGVAAEGHATEIRFTGNAVATLELASPDDVPREWLGVGTFPQATLDSLADLGRIVGRKDQTLSAFGFDRAELVEFVRSLGGRGIDRVVPFGKALDFAAIWDGYDLLAEFSRLTTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZU3</accession>
    <name>A0A7W7WZU3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">F4559_006572</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4969213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="30675" checksum="1B8E6A01FB6AC262" modified="2021-06-02" version="1">MPELPEVEALAHHLREHAVGRVVHRVDVSSLQVLKTFTPSWTELHGRAVTGAGRHGKHLDLDCDGLHLVVHLARAGWLRWADNLAVAPPKPGKGPLALRVHLGPPGEGPGFDLTEAGTKKGLAAWIVTDPAEVPGIARLGPDALSVSRTQLEDLLSGRRERLKTALTDQTLVAGVGNAYSDEIMHTARLSPYATAGRLPGEALDRLHDALVSVLTDAVARSVGQGAAKLKGEKRSGLRVHARTGLPCPVCGDLVREVSFADKAFQYCPTCQTGGKPLADRRLSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXC4</accession>
    <name>A0A7W7SXC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26451" checksum="23B41871F19F54F6" modified="2021-06-02" version="1">MSIDVLLLTAEPDHETVLPALTLLPHAVRPLRPEVSALLEAGPHDVVLVDARTDLVAARGLCRLLDSGGVDVPVVAVVTEGGLVAVNADWNVDEILLPTSGPAEVDARLRLVRSRRGVEKQGGDGSLQLGELVIDEATYTARLRGRPLDLTYKEFELLKYLAQHAGRVFTRAQLLQEVWGYDFFGGTRTVDVHVRRLRAKLGPEHESLIGTVRNVGYKLVRPPRQGAARRPAPLLDELAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXL4</accession>
    <name>A0A7W7SXL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-quinone oxidoreductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="2">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19356" checksum="D18F90ECEF3CCF4B" modified="2021-06-02" version="1">MTTSDADLVPGAVVKTAFGQTTAHVEPDTWHASAATLHAAGFALFDWLGVEDAGRPGASGTAHAVLLHVINPDTRRGVLLRTVLTGTLPSVADLWPGAAWHEREAAEMFGLALDRPAERLLLADSFAGHPLRKDFVLAARVVRPWPGRLEPGEDGTSAPSRRRTAPPGVPDPSWGPRREDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY65</accession>
    <name>A0A7W7SY65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/H+-dicarboxylate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="45624" checksum="21D6D7BE8AE9C030" modified="2021-06-02" version="1">MSFIHTYRKPKVFGIAVLVALVLGALVGWLAKTNDQEWLVTTLGHLGDVFTSLLQLTVIPLVFTAIVVGITSLNRLGRTRAARLGGKTVLWFAITSLIAVLIGLAVALLVKPGTGVDVTPTDAAVKRLASREPGSWTTLVESLIPSNLFSAFTEGAVLQVVFIALLVGFAAFALGERAAPFVDFTRAAFDLVQKIVGWIVLLAPIGVFGLIGTAFATYGNSFVGPLFSLIVSVYVGSLIVLLVVYPVLLRFVGRVDPLTFFAKAWNAIQFAFVSRSSGATLPLSKRAAEDLGVDRDYAAFAVPLGTTTKMDGCAAVYPAVATVFIANLVDVRLGVWQYVAIVAVAVFGALATAGTTGWFTMLTLTLAAVGLPTEAIALGVAVVYAIDPILDMIRTATNVAGQITVPVLVARSEGLLGETTAPQPPPVPRRAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY97</accession>
    <name>A0A7W7SY97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15078" checksum="046F33B2DE172832" modified="2021-06-02" version="1">MSITAAWQVYDGRPGSGETRVADTPADVDSLVVALSRGTSGVARIEHDTRPHRPHPFTGEPAADHLVMACVGDDFCYLYHVDPDHDPGHPVGDPASPVYHSDSEEFPAGSGIPVETLATALKEFLATGQRPTCVDWTPAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYJ5</accession>
    <name>A0A7W7SYJ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Simple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="36597" checksum="BF95FACFD56C7679" modified="2021-06-02" version="1">MGILRGKLLPPALAILFSALLCGIALVVSGANPLKAFGAMVSQVGEGTTAVDIVNSTGTYYIAALAVAIGFQMNLFNIGVEGQYRVAAVVAAVFGGSFALPAGLHALAIIVVAALVGALWAAIPAVLKVTRGVNEVISTIMMNGLALGLAAYLIREDVFGELRGNNIRTPEIAESGRVPGIPLGDNGTVFGLVFLAAALGIGYWVLMNRTRFGFELRASGESTTAAAAGGVSAKKMVLIAMLLSGGIAGLVSMPEILGRDHTYNLNFPAGIGFSGIAIALLGRNHPGGIAFGALLWAFLDKSGLALDNVGVPREIVTIMQGSIVLSVVVAYEVVRRFELAARQRQVGKQLGTVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU9</accession>
    <name>A0A7W7SYU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="5783" checksum="4DE49301C4923880" modified="2021-06-02" version="1">MLSPLMPGPDPGRHSTAGLAGIPRRLSPDDGLVVGDHGSTDDPLGVPTGEDPAKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW3</accession>
    <name>A0A7W7SYW3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6954" checksum="EE67187023CEAAF1" modified="2021-06-02" version="1">MDPRLLVHLTGCSYQHETREPGPDGDRLTDHSALVVHLAIEPVDRLLTSDPITVAAHVEPTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE0</accession>
    <name>A0A7W7SZE0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="29772" checksum="5B52420D3D205C8A" modified="2021-06-02" version="1">MTPEDVVGRIRPYVRWTPSWRVTVDGRDVVLKLEHLQVGGSFKFRGAVSALTDGPPPERVVTASGGNHGLGVALAASVLGVPATVYVPETVPEGKARRIKAAGATLVRHGNTYAEAAAAAREAPGRYVEAYDDPAVVAGQGTVALEIVADMPEVDSIAVAVGGGGLAAGTALGSKRLTVAVEPEMCCALNRALHAGGPVDSPVESVAASALGATRVGMLPFEVLSRYPVTSVLVSDAELSAARDRLWEEFRLAVEPAAAVPFAAWLDGRVPGHLPCVVLCGANTDWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ7</accession>
    <name>A0A7W7SZJ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_001221</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="529" mass="56615" checksum="0C22B253DDFFD20F" modified="2021-06-02" version="1">MTTLGDSFHVYDTTLRDGAQREGISYSVSDKIAVARLLDSLGVGFIEGGWPGALPKDTEFFARAAAGDLTLKHAQLVAFGATRKAGVKVHEDQQVRALLDAQAPVVTLVAKSDRRHIELALKTDVAENFAMVRDTVKFLVDEGRRVFLDAEHFFDGFAFDPDTALRTLESAVEGGADVVVLCDTNGGQLPLGLAETVHDVVARTGFRVGIHCQDDTSCAVANTIAAVQAGATHVQCTANGYGERAGNADLFAVVGNLVTKLGLPVLPTESLAELTRVSHALAEIANIAPDSHQAYVGSSAFAHKAGLHASAIKVDPELYNHIDPETVGNGMRVLVTEMAGRASLELKGREFGIDLTRRPDALTNVVRKIKELEAAGWSFEAADASLELLLRDELSELDAPPFTLESYRVVLDHQKDGGIVSEATVKVHVGGERVIATAEGNGPVHALDAALRKALRPHLSWVDSVELNDYKVRILTDQHGTDAVTRVLVESTDGEREWTTVGVHGNIVEASWLALCDALVHKSLSPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU2</accession>
    <name>A0A7W7SZU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23110" checksum="78EBA9E9C24AD6FE" modified="2021-06-02" version="1">MIRVLIADDEPLMRAGIKAILGTADDIELVAEAGDGREAVRIALERRVDVAVLDIRMPRLDGLAAARELRSVAPSVRVVVLTTFGEDDNIVRALSDGAAGFLLKDSAPEELLRAVRAVYGGEAYLSPMVTSRVVGMVAQVGQPRRQEAMRQVQGLTDREVEVLSLLGLGMSNADVGQRLHMSEATVKTYVSRLLAKLGLTNRVQAALLARDAGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZV5</accession>
    <name>A0A7W7SZV5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17290" checksum="AD379940720FFE5C" modified="2021-06-02" version="1">MTPDTPADVVAPALVRGLAEELESPADDAPKALEQAWSGLRTARLLGLRLSTVDLMWRRRQGNAEAVEFQLARDLGTSATFARVDLALPMPASVVPLPADEADAALVALIRFSAAARRHMLAAAPLAEHWHDERVLRHDSKVFGSLGEAWLGRRAGFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX7</accession>
    <name>A0A7W7SZX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein YqaA with SNARE-associated domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18429" checksum="4129CB8DFE08EDFC" modified="2021-06-02" version="1">MLGLLFLTFGVAFGSAILPFISIELFVLGMVTQQPGISWWWIGIAVALGQVLGKLLYFFAARGDLHLPKFLRRKERPTKSLSPRRQRWKNRMDRVRDRCHRHPHWMFGTHAVSSVVGLPPFMFTTVLAGLAGMSSSLFVTTSVLGRFARFSVLAASPGLLTAWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T056</accession>
    <name>A0A7W7T056_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">F4559_001512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19285" checksum="71420A4D8A043C0D" modified="2021-06-02" version="1">MEERNMVRLSKRMSRHLRHAPQEIGLTPDPAGWVDLDAFVAALRVPRDHVLEVVERDNKQRYAVEDGRIRANQGHTIEVDLDLPATEPPAVLYHGTAERVVPEILDKGLRPMRRHAVHLSTAVDTARQVGGRHGRPAVLVVDAAAMQEAGHVFRVSANGVWLVDAVPPEFLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J4</accession>
    <name>A0A7W7T0J4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase YjhB (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22147" checksum="A025A20778776396" modified="2021-06-02" version="1">MLPGTSTPHNPDRPDRRHPALTADAVVLHRVGHDWWVLTVARGKDPYQGQPALPGGHVHPDETPLAAAIRELAEETGIVVPGRWHHVGGYADPGRDPRGDYATLAYVTVATFLPVPVAGDDAATAEWRRVDDGLYDRLGFDHARIVRDAIKTAKRLAAPVLAPVSAENTDRYEQARRLSGSNDPVVITRLADWLSTPQTGDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M7</accession>
    <name>A0A7W7T0M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021215">
        <property type="entry name" value="DUF2752"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10825">
        <property type="entry name" value="DUF2752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="13731" checksum="FB7FC29BB39CB7BC" modified="2021-06-02" version="1">MGWPRGGFGRVRQPVLVAGLAAVAAGVLVFVDPTGPGSWLPPCPLFALTGIQCPACGSTRMVHALIHGDVVAAWHFNAVMLVAGLPLLAWLWVRWLRAARRGTAAPVGNRVGVPVLVVAVLWMLVRNLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D9</accession>
    <name>A0A7W7T1D9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_002120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="282"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="374"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="558"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="650"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="742"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="834"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="1348"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1470" mass="156900" checksum="E469237CAE529A36" modified="2021-06-02" version="1">MTTARDDTDITLDRLVAAMREMRDGNFRRRLPVPRDPRAAELAEVYNEIAERNQWLVGELMRVRQAVGVEGRLGERLSPGTGPGGWDLAVEAVNGLIGDLTRPTAELSRVLAAVAQGDLSQEITVAARGEVAAVVESFNSMTATLRTFAGEVTRVAREVGTDGRLGGQAQVPGVAGTWKDLTDSVNFMSDNLTAQVRDIAQVATAVAQGDLSQKITVTVAGEMLELKDTVNTMVDQLSAFADEVTRVAREVGTDGRLGGQAQVPGVAGTWRDLTDNVNFMADNLTSQVRNIAQVATAVAQGDLSQKITVDARGEILELKDTINTMVDQLSSFAAEVTRVAREVGTDGRLGGQAQVSGVAGTWRDLTDNVNSMADNLTAQVRSIAQVTTAVAQGDLSQKIAVDARGEILQLKTTINTMVDQLSSFAAEVTRVAREVGSDGRLGGQAQVPGVAGTWRDLTDSVNFMAGNLTSQVRNIAQVATAVARGDLTQKITVNARGEILELKETINTMVDQLSAFADEVTRVAREVGTDGRLGGQAQVSGVAGTWRDLTDSVNFMADNLTAQVRSIAQVTTAVAGGDLSQKITVDARGEILELKSTINTMVDQLSSFADEVTRVAREVGTDGRLGGQARVPGVAGTWKGLTDNVNGMADNLSTQVRSIVAVATAVAGGDLSKKIAVDAKGEIAVLADTINGMVDTLRAFADEVTRVAREVGTEGILGGQARVPNVAGTWKDLTENVNFMANNLTSQVRNIAQVTTAVAKGDLSKKIDVDARGEILELKTTINTMVDQLSSFADEVTRVAREVGTEGKLGGQAEVEGVSGTWQKLTENVNELAGNLTRQVRAIAVVATAVTAGDLTRQITVDASGEVADLKDNINRMIGNLRVSTRANQEQDWLKTNLARLSGLMQGHRDLNAMASLVMSELTPLVSAQHGAFFLVDGESDALELTATYGYQPRGGRPTRFARGESLIGQVAVEKKTVLVRDVPPGYLETGSGLGSAPPANLVILPVVFQGETLGVIELGSFGEFTGVHLDLLDQLRENIGVNVNTMLANARTDSLLVESQRLTEELRAGSVELEARARQLSSASKYKSEFMANMSHELRTPLNSLLILAKLLADNLDGNLNAKQVEFARTIHSSGTDLLQLIDDILDLTKVESGHMQVQSESVLVADVVAYVKAMTSPLAAEKHLAFGVTVDEDVPSTLHTDEHRVQQILRNLLSNAVKFTHDGEIRLRIRLADGGAAFDVHDTGIGIPADKLSVIFEAFQQADGTTSRKYGGTGLGLSISRELATLLDGRLDVRSEPGVGSTFTLFLPLGDQSLVPPVVEAALPEPPSTELVPELPPVPMRFHGEKVLIVDDDLRNVFALTSVLELHGLQVIYADNGITGVRALEQYDDVTLVLMDIMMPELDGNATMSAIRAMSRYADLPVIAVTAKAMKGDREKSLASGATDYVTKPVDTEHLLRLIAFYLGVEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G1</accession>
    <name>A0A7W7T1G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7618" checksum="7E8333A56A2EA4DF" modified="2021-06-02" version="1">MTHHQPTLSLRRDARTERRVWTVFAALFLLVAGANALVALSEDAWWQLGAAAVFLAVAAGCARRARGGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T221</accession>
    <name>A0A7W7T221_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR system Cascade subunit CasC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01869">
        <property type="entry name" value="casC_Cse4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="41140" checksum="807C8179ABA22A41" modified="2021-06-02" version="1">MPRTILDIHVIQTVPPSNINRDDTGSPKTAMYGGRRRARVSSQSWKRATRDAFDHLLDTDELGVRTKRVVELLSEAITDQVPELVDRSVKLAEAVLTAAGIKISQPRKKEALQESGYLLFLSNRQIASLAELAIEAAVAAGEDGKLDIAKADVRARADEAHSVDVSLFGRMVADATDLNVDAAAQVAHALSVHAVSNEYDYFTAVDDHKKRDDEEDAGAGMIGTVEFNSSTLYRYATLDVDRLRDNLGDDEATRRAAEAFVRAFVTSMPTGKQNTFANRTLPDVVLVVARESQSINLVGAFEEAIPDDAEGGRIVQAATRLAAHARELHEGFDETPVAAWVFGAGDRKVAPLAEIAERTTLGPTVEALGQLVSARLAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L0</accession>
    <name>A0A7W7T2L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002814</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="5">
        <location>
            <begin position="99"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="720"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="840"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="937" mass="101560" checksum="3CB58DACE22FFEC4" modified="2021-06-02" version="1">MVVELRVLGSVEAWVDGLAVDLGPARLRCLLTALVVEPDQPVTADRLVERVWADRAPRGARDTLRTYLTRLRRALAVTDEVRIGRRAGGYVLTLDPAAVDLHRFRRLTAEARTTDDGQAAADLFGRALALWRGEAFAGLDGHWISAVRTELEAERVEAELDRTDLLLRHGRHHEPLPGLVTRAAERPLDERLAGQLMLALYRCGRQAEALDGYQRIRSRLADELGADPGPRLRRLHQRILTADPTLTTTLDTPSDTAAAKSATAPPTPPRQLPAPPRMFTGRSRELGVLGAGPEADLMIATISGTGGVGKTWLALHWAHRHLDRFPDGQLYVNLRGFDPGARPVAPAVAIRGFLDALGVAAGAIPSDPDAQAALYRTLVAGKRVLVVLDNAAGAGQVAPLLPGGPPCAVLITSRNRLTSLVATHGALPVPLTMFSHDEAHELLVGHLGADRLAGEPEAAEDLLRYCAGLPLALGIVTARVATDPGMPLAVPAGELRDLSTRLDALDTGDELNARAVFSWSYRTLGPATAKLFRLMSRHPGPEMGGSAVASLAGTPAGTVRPLLAELVRAHLLTESRHGRFAFHDLLRAYAIELADRHDTEADLRRAVHRLLDHYLHTAHTADRLLEPLRDPLVLAAAVPGAVLDRITDHRRALDWFRTELPALVGAVGLAAGHRLDEHAWQLPWTLVTFLDRSGLWTDYVATQRTALDAARRRDDRDGQARAHRLLGNALGRIGRDDDARKHFGEALDLYDDTGDRVGLARTHRAICWLLGQRGRFTEALHHATCALELFQAAGHRSGEARAVNAVGWYHSLLGDHASALRLCESALALHRELGSTDGEASTLDSIGHAHHHLGDHVRAMACFEQALSLYDELGDRNGKIESLCHLGETRQAVGDLDAAARAWRQALSIMEEVGHPDADRIRAVLARTSGQAPVDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y4</accession>
    <name>A0A7W7T2Y4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="32600" checksum="B964041BC1CDDED1" modified="2021-06-02" version="1">MTDLPTRADVEEAAFRIAGVVARTPVLHSPALDERTGGQVLLKCENLQHTGSFKVRGAANAVARLDPRHLARGVIAFSSGNHALAVATAAKAAGSPALLVMPSDAPAAKFAAVRGLGAEVVTFDRYTDDRFALTARLAAEHGLTPIPPYDHADVIAGAGTTTAEFLDQVGSLDVLAVPLGGGGQLAGATLVSGDVRLIGVETARGDKNRRSLQAGHRVRIPVPRTIADGVTGEIPGELTFPLVRRGVERVVVVDDDEIRAALAFLFEEVRLVVEPSGALAVAALLAGRLDVTGARAGVVLSGGNIDLARLHDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z5</accession>
    <name>A0A7W7T2Z5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RDD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25879" checksum="F682FBF6A69661FF" modified="2021-06-02" version="1">MRTQSAYPRNLGRRWIARLVDWALILVITSPLWVVAVGHVKHSAAFAAVSTTGSGVLEVVALRWDEAGDQATAGLSEVWDAIVLSVAGAAVAQVVLVALYDFAAHALFGRTVGKAVTSLVLTPVDGSRRVRATRALARASITVLLPGLGWVALIVAVLRLDVLIGLVGVALLVLSTVECLSLRGPSCWHDRRTGTTVRPVDWAAKLAAVRDSTAWAVAQQAPRRVADQGRSLRDRFGGGGPTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T344</accession>
    <name>A0A7W7T344_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030892189" evidence="1">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="26471" checksum="F5C59C3397BC1C5F" modified="2021-06-02" version="1">MVVASALVTFFALVAVLTPTPVDARVVAARTLEAAKGSPTTGAIADDVAPRLPEGARAVVVKPGGTGERAGTGEVAVLVGDVDRSAASLLLSGGVVATQQSDDGWWVAVSVPDPRSPPLGAVLALLTGAVVLGAAATELHRPKRRDDLLVRGLANLLPDLPAHAAWRARGLLIAGGVRPVHPDEHRHVVGTVPTDDEALVGTVARTVRPGYADGDRVLVRPAVFVYVKTDDQGCPLRHTFPAQGRVLRRGNGPSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T470</accession>
    <name>A0A7W7T470_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="444" mass="47855" checksum="54ED8B387EA617F3" modified="2021-06-02" version="1">MHPTPPGSPSDPGSTSSEDGRRFPAREPSLHERLLELEQEEEADAAATGHADDDVDLDDLLAGMSGQATTWEEIRRRGRELLVSLSFDVAAEPGPGPRGPSPAPVVPYPTADGRAFATSGPERVGHLTGDALGAGIVGLLIERQDTGTADFAPVVEAVRARFDELAAHDGSAGRHEPHAAVLSALLAARPALVGLRESVEDPELDLPLPQAAAVVRFLAAYPHFQATLTTLVAAIRFDSGTADGFGGGVFSPHGDGCVHVSRLRDTPPGAFVRLFVHETGHAAFEATLLGRREMQPVLGRGQAGHLIAQPSGENFEEADHDPVMWSAELRDLEDFWASTSEEARNLYRAWLVLRVDGGRHLLGQDLWAFGKRRLSADQRRVYQAGKFIEFCAEVFMQYALGDLRPFLVELFADPHVEDGIAVAWRHVWDVLETVAAPLLGARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T477</accession>
    <name>A0A7W7T477_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase</fullName>
            <ecNumber evidence="2">4.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32904" checksum="E3DE6755414C338B" modified="2021-06-02" version="1">MTSEPVLAEIAPGVHAWVQPDGTWWLNNAGAVHAGDEVVLVDTCATRARTLAFLDAVDAATGGAPIGFAANTHLHGDHVHGNALLPDTTTIVAHELTRRGILADTILKNTPPAWSPTPDWDIDELRAPTLTFRDEVTVHAGDTPIVLRHPGFPAHTVGDVVAWLPDQRVLFTGDLVFHGVTPLIAMGSVTGAAKSVDWLRTFDPETVVPGHGPVIDRNAWEEVLETHTRYYTFVRTVADHGLTHDLTPLEAARQADLGEFAALPDAERLVANLHRAYAELDGREFDITAALGDAVAYHGGPLRCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T493</accession>
    <name>A0A7W7T493_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="533" mass="56943" checksum="AF2392540B365EBB" modified="2021-06-02" version="1">MTTDVLIVGAGPVGLALALDLAHRGVDFTVLEAGDGTVRHPKVSTVGPRSMELFRRWGVAGRIHRAGWPGDHPLDVAWVTRVGGHELHRLRRGTADTRPVPDHTPEPDRICPAHWLTPLLLDEVGVHPKGPVLTRHRLDGVVRHADGVVAEVTDLDSGRTASIAARYLVACDGSASPVRELCGIGAPPRHETRVFRNILFRAPELRDGVGDSAAMVYFLMASPSLRFPLRSIDGAGLYNLVVGTGEGPEARSLVTDAIAFETPFEILSDKRWYLTHRVADRFRDGPVFLVGDAAHTLSPSGGFGLSTGIAGAADLGWKLAATLAGWAGGGLLDSYEAERRPVAAASLEAANANLVRTIDRSTPAGLDADTPEGARARAEVSRALAAGGVAREFDDPEVHFGLRYSSPLIVTEPDTGAAESGPWHPAAVPGSRAPHAWLRPGVSTLDLFGRGFVLLCFPGADRPDTVARAFTHRGVPLEVMRCGCADPELAKLYERRYVLVRPDGHVAWRGDEPPADPLELVDTVRGARTAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B9</accession>
    <name>A0A7W7T4B9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monoamine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030584498" evidence="3">
        <location>
            <begin position="38"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="471" mass="49203" checksum="590029D09FE1CD8B" modified="2021-06-02" version="1">MSSGEQEQRVVGRRSVLKAAAGVAAAGLVATPAVAGAEETGGWADVIVIGSGFAGVTAARDLRAAGLRPLVIEARGRVGGRTWTSSFEGQTIEFGGQWVGDVHTNAIAELNRYGIATKPGGPLPLRAFFPNASGAQQEVDFLTANDHLNSLLAQLFEGSADYFPQPRNPLYAQGVLANYEPLSLQDRLNQLTLSTQDRLWLGGMTGVFSGGTSTRGALTAFAQAWAGGGHTGQGWNELQEYLIEGGTGALLGAILADARPDLRLNSPVVSVTQEPGRVVVTTRSGARYRAPAVVVTAPVNVWHTIDFTPGLPAVHTAATTQGVGVPNAAKLLIRLAGGPRLPFALGAEGAPMSWIVPQTELANGDQLVVGFTVDPTINLASVADVQAKVRTILPGATVRGFRAHSWWRDPWAQGGWALRSPGQLLQQVPAIHQPQGRVVFASGDVPAAWHGYIEGAIEAGKIGAAQALSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I7</accession>
    <name>A0A7W7T4I7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31575" checksum="BF26C1F3CF29B380" modified="2021-06-02" version="1">MDDDRSTSSRSTFWWWGQPGLLWDRGKVAANHEYDYDSEDLRAVHDLLGVQDSEKNAHTLIVERYAASKNKDPDPQLDVEYILINAEFTWGAQAALAGVIGNAVYDGAKSAVRSFVRRCRRKDNSGLDAGEAEAFALYVVAYLVVRKQVEISLWSNHPPKAVAVAKEGDHWICRFEKSWFTQLREKKSPVRTRKMDAIWKRTIEIRLEAGSPSIPDSHYRMGTELRLATPAEAQSRRRGGIAEIYGGEADRHGLGEKLGTVWKRVGSEMPQGNVDTGGICGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4L4</accession>
    <name>A0A7W7T4L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="30945" checksum="70F0C65902976065" modified="2021-06-02" version="1">MPTLGRVGLWLAGLDFRPAAETTELAQEVDELGFSTLWLSEGLMRDPFVQSALLLGASERLVVGTGVTVIWGRHPMRTKVAARALTDVFPDRFVLGLGISHPLVVEGVLGLEYKRPLAALRDHLEEMDAIDPLKRVFGTADTEPRAPRVLAALGPKALALSRTHADGAITYLVPPEHTAQAREVLGPDRTLVVEQAVVVDPAHADRADEHVALYSGIGPYLANWARLGLTERNRVERLVAIGEEAVARRIDEHLAAGADQVCLQVLTPDSPLPDYRRLAPLSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y2</accession>
    <name>A0A7W7T4Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="28919" checksum="CEB968B3356200D8" modified="2021-06-02" version="1">MTDPVGIRAVSRELIAADGRLGARNVVDRAVRAAWSAGPPTADRERCAALAELFEVAGWIAYDAERQDDAARLDDRALVLARLAGDRAMENLVKLNMSLRAAHVGRYGDAVALARSVVGGGSRVRTLCLIREARAHSKAGSEAAVGLMRGARAHFLDGPGAREPDWAWWIDDLELDGHHAGALLDLGRPGAALPLLHRVVEAMGGTDQPNYRVIWQVRLVEALLAVGDRAEAEAVLERLPAIGSARALRSLRSLLGAGAYREVVSRNPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T509</accession>
    <name>A0A7W7T509_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Robl_LC7" evidence="2">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="12742" checksum="9C3D9FCC30F4130F" modified="2021-06-02" version="1">MDYDALAAELRKLRENVSGVTDTVIAATDGIPILTDVAKRVEPAHISALAAADLGIARQAAEVIGLGKLSQTVVFGSAGYMAVYAIGGMSLMVVLGDEGLNLGRLIYETRPVIERVNSILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T541</accession>
    <name>A0A7W7T541_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="197"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="34590" checksum="4D71BDE171888C74" modified="2021-06-02" version="1">MTSEAPLQTVPLPVHRFDDPLIADGPPGFAIGSFADLSPWSDAPFPHRHDFYELVCVTGGSGTHVIDFVPYQVRPVTLYFIAPGQVQFWERRSPLEGHVMVFVEEFLVPQYDRVSPRRSLSLDPLGTGHALPLSGGQVEPITGLITALEREYRRPGGADVSVLRAYLHILLVEMRRLHRGVVGGADEDEDRGTALARRYLRLVSEELPNEQTVRGYADRIGVTPKHLADVVKRTTGKRPAEIIRAALTVEAKRLLTHTDLTVAQVSERLSFDNPSYFGRFFKRECGMSPGEFRRRAGLADNLRSVTRTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G1</accession>
    <name>A0A7W7T5G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="549" mass="61547" checksum="766EC136F9765D97" modified="2021-06-02" version="1">MAERESDVTAGLDHVLTAHQPFGPIVTEDVVHLGPDTADRLFDRSNRSYRQAAGEDTPTYIIGRKGAGKTAFLMGSNHVAGPAREVLRTENVYHEMLKVLTTYSRDHEPFVDQRAEIWQALFEHVAMLHAWSGFDGDDRRGRLNTIAGYLGRSTEPGVTGTAVAERFLVALRRRLLDHGGEGLSEAIANVTHDGQVPFGAARAATLDLLAERPRPLLVVMDNLEDLHLRLPELTPALTGLFRCAGTVIARHHGHRPYGVQICLPSELFDKIHELAAAPEKDLRGRYLKIYWTAPELLRLTANRLVLFLRTHHPEQLAMLERRAAHNDEPDPAIAVLRAALPDRVRSGLDIDEDPLAYLLRHTQLLPRHLIQILNSVFSRRDRGSTPWDVTPAAVLAGTRYAEHPLVAGVLAAYQTSYPLAGAVLRRLAGRIDLSFPARGLHRVYNQQGIRKLTGLDFDEFLAMLFTLGVLGVRFDQTGRYNKAHFQYTFDYDLIAREDADQLCVHPLFTRYLLERSLPRLREAGAHATYPYGCDPRGEDYRDAFGYLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G5</accession>
    <name>A0A7W7T5G5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32219" checksum="1A8927339A35CD4E" modified="2021-06-02" version="1">MLVERASVVLTALNREGIPGRGTEPTLADDSAWASDTVVAVASALEACLQQADACQAEVAELRQQITFVYAGVEVFDEDHLETLVRSTNVKVETARRECREAERALPVCQELDARLAAARPVVEGLHEPVKLLADGKFVDSVVRRRQGTPLGTASQIFESMTDGRFGFAAKFKIVDTTTGQVRDVKTLSGGETFLASLALALALVGVTSRGAGRVEALFLDEGFGTLDTNALHQALSESHRNAGDGRLVAVISHMRDVADNFENILMVEKTPRGSNAKWLSPEQRDELMADDLASGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L4</accession>
    <name>A0A7W7T5L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional isochorismate lyase/aryl carrier protein</fullName>
            <ecNumber evidence="3">3.3.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7495" checksum="656D758681F8A705" modified="2021-06-02" version="1">MTTDDVRAGIAAVLDVPASDIADDDNLLDHGLDSVRVMSLVEGWRAGGAEVAFVDLAENPTVEAWTALLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T6</accession>
    <name>A0A7W7T5T6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4/cobalt-precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
            <ecNumber evidence="8">2.1.1.271</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EC" id="2.1.1.271" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="25590" checksum="BE37B00FD965135D" modified="2021-06-02" version="1">MTVHFIGAGPGAADLLTLRAARLIAAAPVCLYAGALVPVEVLDHCPPGARLVDTANLTLDEIVAELLAAHEAGHAVARLHSGDPSVFSAMAEQMRRLDALGVPYDVTPGVPAFAAAAASLKRELTVPGVGQTVVLTRTAARATPMPPGEDLESLGRTGSTLVLHLAVQRITEVVADLLPHYGPDCPVAVVARASREDELVLRGTLADIAGQVLDAGVRRTAIIVVGRVLAAEGFVDSHLYSAARCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z0</accession>
    <name>A0A7W7T5Z0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="11 14">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ruvC</name>
        <name evidence="15" type="ORF">F4559_004557</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 14">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="11 14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4967198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20384" checksum="48FCFD81EFF84935" modified="2021-06-02" version="1">MRVFGVDPGLTRCGFGVVDGGPGRTVRPVAVDVIRTPADEDLSRRLLQLSDAVEKWLDDHRPQVVAVERVFSQHNVRTAMGTAQAGGIVALAAARRDLPVVFHTPSEVKAAVTGSGRADKAQVTAMVTKVLGLKTAPKPADAADALALAICHLWRAPMKSRLDEARARAEQLARTHRAKLAEARERMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T620</accession>
    <name>A0A7W7T620_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25245" checksum="16E846592B2D0646" modified="2021-06-02" version="1">MTNVAERMGERERRTLRVCAHLLSDWGYKRVTVEAIASRAGIGKGTVYLHWKTKDELFGAVLVQQSVEVIRELGEVVRANPYEVRLHRMVGHYLTAVARRPLVRAMFVRDQEVLGRLAHSGPPAVAALRQATNTLFLRYFDAVVRLGLVVPGCDPVAVRRTVGMLTCGALMQRDEKVPECVRVAADLARRAFEPRAGMSSNSITTAAALVVDLVDGFVPANSPALTGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T653</accession>
    <name>A0A7W7T653_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="512"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1565"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1664" mass="178871" checksum="7F76A6CE971AA9F4" modified="2021-06-02" version="1">MSANHSAARPLTGPLPDLVAAQVARTPDATAVVSGTASVSYRDLLDRADRLAAALRGRGVGAEDVVGVSLERGIDLAVALLGVWRAGAAYLPMDPGHPVSRIEWTIADAGTRFVLTDAPDKVRAAGAEPLDVEATTRAGLAGGTGVRVASTQAAYVAYTSGSTGRPKGVVVTHGGIANRVTWTARTHGLSEVDKVVQKTSMSFDAAGWEVFAPLITGGTVVMAPTGAERDPGLLTRTIAEHGVTVLQVVPTVLRMLVDDPGWGECRSLRLLFSAGEPLHAELVQKALAGPRPTVWNTYGPTECSIDITAQRFDPAQTEGPVPIGSVIDNGRALVLDAHGEPVPVGVPGELHIGGLGLARGYLGRPDLTAERFVPDPYGRPGARLYRTGDIAVPRADGGFDYVGRVDHQVKVNGVRVEPGEVEAAVHAHPDVRAAVVTVTAEPKRLVGYFVADREIPVDELRAFLRERLPEALVPTVFVALDALPTTASGKVDRNALPDPDLAVADARPEHVEPVGAAQTAVARAWRAVLDVDRVGADDDFFQLGGTSILLARLAGRLREETGADVRLSDLFTSPTVRAQAELTGGSVAPVVARPRTGGTLPLSTGQSRLWFLDQLRPGSLEWVTPIFLRVSRDIPSDTVRAALNALEVRHEVLRTTYVSEQGVPAQRIGDPGKVELTLVEGDEPHRLDQVRAQLSRGFDLAGGPLWRALLMPVSDDESLLLLTVHHIACDGWSSVVLERELRELIAAHQGDREPDLPAVGLHYADFALWQHEHVTGEQVERDLAYWRANLAGLGPLELSTDRPRPAERDARGGMVAFDVPPALANRLADLGRRQGATPYMAFLACYMVLLARYTDQGDIAVGSPVAGRDRPELADLVGFFLNSVVVRGDLGDDPTFADALVRVRDAARGAFAHQVAPFDRVVDALDVPRDLSRTPLYQVSFDFHEEGLTGTTDDASDVDEFADAWRVAKTDLTLLMQRRGDGGVTGYLEYAAALFDRSTVERFVGHFLGLVEAATADAGKRLSALEFLDEAEHALLVARPADPGYAVDRGLHAVFAESAARFPHSTALVFGDEVLSYRELNERANRLARHLVSVGVTPGSLVGICQPRTDDLLVSVLGVLKAGAAYLPLDPAVPDERLKFMVEDADVSVVLTHAAVATDFFTGVRVVLDDERQAAAIAAHDASDVDNGTGVDDPIYVIYTSGSTGRPKGVRLTHRNVARLMHACHAEYAFSPDDVWTLFHSYAFDMSVWEMWGSLLYGGKLVVVPQSVTRSPDEFLDLLVEHGVTVLNQTPSAFKGLVNLAAAGDPRLRDLRLRAVTFGGEKLEMGELRPWVELFGTSAPKLVNMYGITETTVHTTYYEVTREDVENGWLNPVGVPLADLSVHLYDRHGRLVPVGVPGEIHVGGPGVADGYLNRPALTAEKFVPDPYAPGQRLYRSGDLARRNPDGSLEFLGRIDDQIKIRGFRIELGEIEAVLADAPGVRDAAVVLREDTPGDRRIVGYVVPAAGADVSPRELRDFVGVRLPDYMVPAALVVLERLPLTNNGKLDKRALPAPTDDALARVDFVAPAGVVEERIADLISELLGVDRVGAGDSFFEIGGNSILAVRLTSLIGEEFALEFTVRQVFEHPTVARLAQAVEDAIRAEIEHMTDAEVLAHSADDKGFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A2</accession>
    <name>A0A7W7T6A2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="335" mass="36275" checksum="9ADE37FC93DB607F" modified="2021-06-02" version="1">MRIVVTGATGNVGTALLRRLAAGPDVRVHGVSRRRPDPVEPYAGVDWTPVDLAREGAEEVLSGVFADADAVVHLAWKIQPGRDETALFRTNVAGSDRVFHAAVAAGVRHLVHLSSVGAYSPAVKDRPKDETWPTDGVRTSAYSRHKAAVERILDGLERDHPDLVVSRVRPGLILQPEAASELRDYFLGPLVPTWLFRTRVPLVPLPDNLVLQFVHADDVADALALLVRERIGGAVNLAAEPVLTPRDLAAALGGRRVPLSPSVLRFLVGLTWRLRLHPSPPGWLDLALTTPVLDTTKARDLGWKPRHDARSTLRALVKAMGVQAAHKGSPPLDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W0</accession>
    <name>A0A7W7T6W0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="47944" checksum="B49D0493E25E9174" modified="2021-06-02" version="1">MSARISVDRVYGADRSGRPTRVAVGHGFAAVVERVGTSWWHGRQGTPWRYVLRVYRGSEELHAVDLPWAVNAVTFHPTSPVLVFAAGQYDGGYRHHGRLSWLDLTTGDVHTVLDENVRRLAWVDRTLVADAAPPFELDGAEAATRYTIDWEGMPDVRTHVLIPIPPHPDDDPGTPGRGAIHAVRALSDGRVLVAGADGLACLDQPGPLWTVEGAAHQIVVDGDGLIVNQSADGVVLRVSLDGVVSSRRTFDHPIVLTSTMTGRVLVHSHAHPVGQLLDGGTVDLGRTDAVNGLFDIARAPDLLVVKDRWVVGVSSGPLFPLEWDEERDARLSGGVGAYLPDRPSLVHTGQVHRACGTVGGFVVRRSYPDGAAEWVTTTATRALASDADAEFTWVATIGRDLTVLSSGTGAEIARLPLADHGIPLAVGLAGRGKVVVGTDLGRLLYCSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X7</accession>
    <name>A0A7W7T6X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12726" checksum="4C4F53B737B0E083" modified="2021-06-02" version="1">MRIGELARATGTTPRALRHYEAAGLIASARASNGYRVYSPAAITRVRNIRHFLDAGLTLEDVAAFESCLDGDVATTSPSPAGLRVAHDRLAALDRRIAAQLEIRTRLANALAHHSIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T764</accession>
    <name>A0A7W7T764_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="9">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="9">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fabH</name>
        <name evidence="12" type="ORF">F4559_005139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="11">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="10">
        <location>
            <begin position="232"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="9">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="33449" checksum="D5E9E0C57916F4AA" modified="2021-06-02" version="1">MSAFSLPAGRVGTGIVGLGSHQPDNIVSNHDLAKVMDTSDEWIRDRVGIVNRRIAAKDERLVDMAVVAGAKAVADAGLAPSDIGAVIVATCTMPSQIPNAAAQVADRIGVKAAPAFDLNAACAGFCYALGTASDLVRAGTAEHVLVIGAEKLSDWVDQTDRSTAIIFADGAGAAVVGPVAEPGIGPVAWGSAGDLVDMIHVADRNSWIFQEGQSVFRWATTQIAPIAVKAVESAGLTLADIDVFVPHQANLRIIESIAKRLKSLGARDDLKVARDIVESGNTSSASIPLALDHMRAAGEISSGDVALLVGFGAGLSFAGQVVRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7J9</accession>
    <name>A0A7W7T7J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009412">
        <property type="entry name" value="DUF1062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06353">
        <property type="entry name" value="DUF1062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20335" checksum="3E0FF4593A174C10" modified="2021-06-02" version="1">MLENWVVLPTRLPLIVRRCHLCAAERFRADGKFRVNANHKLLDAWLLALCTGCGDTVKLTVVERTNVRSLRPGLLERLHDNDPGLAAELLQDPGFRHRNHVAADWDGAWRLDTGDADRADREVLDVSVHFAARIPVRPVRLIAEGLGLSRTEVKRLIEGGELFSAVRLSGSLSGDFAFTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7S1</accession>
    <name>A0A7W7T7S1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="44791" checksum="D7D620016FFAACFD" modified="2021-06-02" version="1">MRALDVGLNAGGVLVGLRERAKVEQRYRREKVIGGVVSPAVINGETMTSSFLGGSLESVSPVHRGANLEAPVVIGEGDRVDRRDMLKIMGATAAVPLAELVNSIGAAPVPRVLGMDHVQVILDSDKFITDWQHLHGGNVARHAAVAQLRNSAELLNCAAGPRVKTELFSALCRFAHTTAFMAFDACAHDDARRTFRFALSCAEEAGDWHLRAAVLSDMARQEFALGDYENSLTRVELALVRSDRLVATERAMLSALRAHALARLGRTAEAVSAIDVADREFADSDFPTNPPAISYYDVAEHAATVGQVFIGLASHGRFVAEAQDRLSIAMDGYGQAYARSRTLAQIDFALVAMKAGDPSQAVSVGIDAVAGASTIKSSRLTEGLRGLVHAGAGHESIPEVADFRHHVGAVVKSRDLVDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7S8</accession>
    <name>A0A7W7T7S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA/tmRNA/rRNA uracil-C5-methylase (TrmA/RlmC/RlmD family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="423" mass="44676" checksum="1D9397C3BE566E50" modified="2021-06-02" version="1">MTGRLIEVEVGAVAHGGHCVARHEGRVVFVRHALPGERVRVLITEDKGGSFCRGDAVEVLVASPDRVESPCPFAGPGRCGGCDWQHATPKAQRALKAAVVEEQLRRLAGLERHVVVEELPGGPADWRTRVRLAVGADGRPGFRAHRGHGVIPVDDCAIAAPGALDAVVDRAWPPGAELVVTRDADHAVHVTEIGPAKRVRGRPVPGPARRRSGSGTATEHAAGRTWHVRADGFWQVHPEAADTLAAVVAEWAAARPGETAWDLYGGVGLFAAVLADQVGASGSVAVVESAAGAVADGRRDLADLPQVEWHVGRTEAVLASPAFADRRPDVVVLDPPRKGAGREVVEAITRSGPDRVVYVACDPAALARDLAVFAANGYRTTQLRAFDAFPMTHHVECVALVEAVPPTGSLSTRSVDWPDDSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U5</accession>
    <name>A0A7W7T7U5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="12"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="29043" checksum="D17334B6E739D9E2" modified="2021-06-02" version="1">MSFAQALGDGAVVAKRNLIKIKRVPDLLVFSTLSPIMFVLLFAYVFGGSIEIPGMDYREFLMAGIFAQTVVFGSTITGSGLAEDMQKGVIDRFRSLPMARSAVLIGRTTSDLVNNVIVIVVMSITGLLVGWRIHSSFLEALAGFALLLLFAYAVSWGMAIVGLLVRSPEVFNNASFVVIFPLTFIANTFVQESNLPGPLKVFAEWNPVSAVTAAARELFGNTNPAFKPADVWPLQHPVLMTLAWVVVFLALFVPLAIRQYRRAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A5</accession>
    <name>A0A7W7T8A5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="380"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="594" mass="64244" checksum="A4177B5D5CAC383A" modified="2021-06-02" version="1">MADRAEDQEAARRASVVADAVRSVVGAGAEHAVQAAVSALAVLPGVVRVFHTTAPHRSGSWAPAAGGHLVVETDPAVPSDVDVVLPVVASAVDALVEDDRFVPTHGFYEELVRWMPAFVVLLDETGVVRWTNIDRWPDGSQVRVDGGDMFEAIATLAHPDDQRSLTDTLAMLRTAPPGTSRNGFVRVRTPEDGWQVLNVVVQNHLGANPVDGLLGFGLDVTETHQAQFHRRLTVARLGALVGALDVGVMLHDSEYRVLVANDALVSLLDLTVPAADLVGFDLSQYLSVAAHPEPYYAELIDLARHFALQDEPVRGEVVALGGGLRMVEVDFVPVDFDARRHGQVWVLRDVTEQERARRDLECRNAELSRLYALKTEFIATVSHELRTPLTTLVGLAPLLGEVLQDPDLPLADAVERNVRRLVNLVETLLFLAKVESGSLPLRRERVDPDGLLRRQLSETRLAAKTRRVVFRLSGGRTGADVQGDADLLGRMLKYVLTSVAGTCERGTTVEVRSTVRDGRWVADVVDPSNVTSTSGRMFVALPQDGTDPFMGSGLGLALARAISERHGGSVWVTTEAGADDQVGTVLRVELPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E3</accession>
    <name>A0A7W7T8E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="32120" checksum="E410DF4DCCB20799" modified="2021-06-02" version="1">MKAIAQNEFGDVDVLEYRELPDPPISFDQVLVEVRAAGVNPVDRLVRQGLAAGALPHHFPLVPGWDVAGVVRAVGSAVDGFAVGDEVFGYQRKDHVQHGTYAELVAAHERGLAHKPESLSFVEAGGLALAGLTAVQALRKVRVSAGDTVLVHAAAGGVGHLAVQIAQALGAARVVGTASPRNHDFLRSLGAEPVAYGDALVDNVAEAVGGDGRVDVSFDCVGGPAVEDSVALTREPGRIVSIVDANVAALGGVYAYAKPVAEDLRWLAGQVDAGALRVEVQRTFPLERAADAQRLLEGGHVRGKVVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E7</accession>
    <name>A0A7W7T8E7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="3">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="3">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshB</name>
        <name evidence="4" type="ORF">F4559_005784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MshB deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="29545" checksum="C0F97F934718236C" modified="2021-06-02" version="1">MTLTAPPRLLLVHAHPDDESLWTGGTIAHYAATGVHVTVVTCTLGEEGEIIPPALRELAADAADQLGGYRVAELRSACAALGVTDHRFLGGIGRWRDSGMAGVAANDHPRAFARGSFDAQVEALSEVIASVKPQVVVTYDAFGGYGHPDHVRAHEITTAAASNDVDRVFHTVTARGALDEGVRGLAELPELPWRLPEPGELPAVPDDTITTTIDISDQVVAKLRALRAHSTQVGVWQDGTDAAYSLSNSIAQPVLRAEHYVLARGRAEGAETDLFGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J7</accession>
    <name>A0A7W7T8J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="18730" checksum="10E115B46867BEFD" modified="2021-06-02" version="1">MVRAVVELGGGEMTVSEADRLAVAAQLGRTPRGMRAVAARCPGGHPAVVLTSPRLEDGTPFPTLYYLTCSRLTSLVSRLEGAGLMKEMTDRLAVDEELAAAYLRAHESYLAERDAIESLGTQVTAGGMPDRVKCLHVHLAHTLAVGRGVNPFGDETLDALAQWWPDGDCASTVENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N9</accession>
    <name>A0A7W7T8N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5921" checksum="6C4BD956575ECE21" modified="2021-06-02" version="1">MTTPPPDPTAEAAARRRRLAEVFGEVLPESDDPPPSARADEWYEENRPPHHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P9</accession>
    <name>A0A7W7T8P9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="24395" checksum="73D4727DEEB9F106" modified="2021-06-02" version="1">MPSSLIVVGLVVAWLVVLVPVVARRRADARSSMEEEYDAMPDAEFDDYEDPADEYDEEVHRPYRPGRGGFDPETAAAVAQAKYAFRRRVVAVLLLVALATGLVAGLLFTPAWWAHGAVDATLFGYLAYLRRQVRIEEDIRSRRQARLTQGRRRPARSPEEDDRHEHDEDRPEPSRPRFEHQVRPGTVVVDMDDEDPAFDELEGLDALPYRRAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T923</accession>
    <name>A0A7W7T923_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="191"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="419" mass="44542" checksum="565C36AA4725B6D2" modified="2021-06-02" version="1">MKLTVVGGGSTYTPELVDGIAGRRTSLAVDEIVLVDPDADRLAVVGAFAQRLLAHAGHQARVTTTSSLEEGVDGASAVLLQLRVGGQAARASDETFPLACGCVGQETTGAGGLAKALRTVPVVLDIAERVRRLAGDDTWIVNFTNPVGIVTRALLQAGHRAVGLCNVAITFQRWTSELLGVTPDAVRLDHVGLNHLSWATGVHVDGVDRLPELITTHGEDLGTHIGLPASLMRRLGMVPSYYLKYFYDHDEVVARQKKEPPRAEVVSAVEKELLDLYRDTSVVTKPDALSQRGGAYYSEAAVQLVHALTGGTGAEQHVVNVRNGGTLPFLPDDAVVEVPAEVTRDGARPLPVAPVPPSISGLISHVTAYEYLALDAAVRGGRDRVADALLAHPLIGQRATAERLADELVARNRDHLAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T971</accession>
    <name>A0A7W7T971_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12350" checksum="0CF927ABCB5826DC" modified="2021-06-02" version="1">MSDEAAVRAFPALTGLVAIRDAGWRFVHHDVVDGIPARVDGYRLWPDGWHDALRVHGDSDAMALRADGDEPPGIVWERTGSLSDVVEGLMSLPAPTQRFAPRLVVASAPALWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q1</accession>
    <name>A0A7W7T9Q1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="28960" checksum="BA8381631D2DD431" modified="2021-06-02" version="1">MCLGRLLGDLLAVAELVDDLGATISRQTSTGQRVGSRSAEIGLPFNLGAAEVRDDLRNTLSTWVRELWETHGPRREVTTGETGPDGSPVVVVALDALYLDDTLHEMAAWLRRHPTWIEYHPAGGELVDEITDAVERARQAVDLPPALVFCGPCPDCGADLYAHPDRATVGCRECESRHDVEALRAALLDAAREHLATAAEVSLALPRLLGRTLSANTVRTWARAGKLTRREPDARGRPRFLVGEVIDVALATPTRQRVTRDVAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T6</accession>
    <name>A0A7W7T9T6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5926 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045970">
        <property type="entry name" value="DUF5926"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19348">
        <property type="entry name" value="DUF5926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5926" evidence="1">
        <location>
            <begin position="47"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33710" checksum="B32C955152FC69C0" modified="2021-06-02" version="1">MAKRAAVKTKSADGVNPRQPCPCGSGKRYKACHGGAGGAADVIVSRPFEGLAAEGELIALREFVPSATVKLPLLDGKREILLATVLPMAAAALVRGDGTAFVGLQVQTRSGDVSRDLARAVQWAQRAETGEALPVVGVDDGSDPGRLQDLLDPAAGLAPELHRDFGWWMPPDAEPSNEVQLSLERANAAILPTERLEAPGVSAAYWVDAGDKAHLRWVRPEPEEKLLAALARLAVRGEHDLGEGSRYAGSFRAHGLLVPVWDLDRELHSSEWSGPADELGKRLRTALTSLDDEPLTEAERRARDGLRGRQITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA14</accession>
    <name>A0A7W7TA14_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="26212" checksum="191FD57A77551689" modified="2021-06-02" version="1">MTGNVRHFGPPWSVDLLADFHAGVLDPATEAELRPIVDNDPEAREILAALDATLADLKDLPVIPIPAHVAGRIDAALAAEAAEAARYRAPVVDLAARRSRKKALGWGSGVLVAAAAAVGAFVLTTPGSTPTNDGVALPTTRAPMTVPGKLTDKPSDSAPLAVKGNNFGPVFGDVLKAQNYGPLENQDTLAGCLRGADVPGGDPIGVSPITLDGKSAVMAILPGGTGQPGQYRIVVLDPTTCGPDNPNGVLANSKFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAA2</accession>
    <name>A0A7W7TAA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="44330" checksum="24F6803E59A491A0" modified="2021-06-02" version="1">MSQTLAHPTTADVVVGRTGKRHSANYRWGILGIGVFAQAAFSATFQGIPTSGSILAAAYGYSYSQLGLVLAAVTAGIFLTEVFWGVLSDRIGERIVLMVGLGGTTLSLAAVTVFLVPTASAAPAAWALAVVLFLSGALGGCVNGASGRAVMGWFPANRRGFAISLRVAAVPLGGALGAAIMPPLAVNVGFRWVFAFLTIFMAAATVAVVLWLDEPPLARTKASDGVAATTTRSPLVRWDIWRVALVAFLLDLPQFTVLTFGSVFLSQVMGLDLGGVVIAIVVVQVLGGVSRVVSGRWTDQVGGRHRRTLVRVYSWLIALAFLGVAAYQVAPTWLVVGLFVAAGFLACGWHGVHYAEIATMAGAERSGTALGLENTMVFGGAFVTPLLIPVVLDLSSWPVVMLLIGVVPAVASAVLMPREARPGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC6</accession>
    <name>A0A7W7TAC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molecular chaperone DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="531" mass="56542" checksum="4113B8C940E1A811" modified="2021-06-02" version="1">MTRRPVLGIDLGTTYSCVASLDENQRVSVLPNQENELTTPSVVFFEESGNVTVGKFAKNELRSEPGRVVSLIKRHMGEDGYTVDIDGKRFFPQQVSAIILKQVVEDALGVLGVDPPADGPMADVVITVPAYFGAAERQATRDAGEMAGLEVLNIINEPTAAAIAYGLTSATATERSVLVYDLGGGTFDVTIIKVSKDEIRVVATGGNHQLGGADWDTRVVELICEKFTEQHAGSDPRTDLDASGTIELLAEEAKKALSRRDAYPTTVTANGERAKIELTRAEYESATADLIGNTLDFTRDVLGKAREKGVDHIDDLLLVGGMSHSPAVKEALVREFPDLPTPQLADPDQIVAKGAALFAASSVAEKDGSGSDGSGTSSPRGLPGGTALPKIVNVTSKGYGIAVVRDPKKPDGDLVVAWLIHPNDEIPARPSDVFRTVSDNQTGVDVAVYESTTDVLSEELYDNLELVKGTLKDIPRAPAGQPFDVSFNLEADGILHVKAVASNGRELKLEAKISGLVPEEVKRAPLPAIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAD6</accession>
    <name>A0A7W7TAD6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YegL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10292" checksum="07A7FB928D96371A" modified="2021-06-02" version="1">MAPRLKARHRVRRPVVFLVSDCRPTDSATWAEAFAALVDPGWPPHPAVFAFGLGAVDLDTLDRIGTSRAFVGQDGILLRTALSVSVASSALRADHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAE8</accession>
    <name>A0A7W7TAE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="15545" checksum="9F9D07C2DFF6C4CD" modified="2021-06-02" version="1">MAEDNGILGMAAGVGGAVGAAVGALITAEKALGKTMPGASASAQQFAVDKETVLQAGKIVFDQALRLNDALRRAERGLLVKLGPNADPVNEDVAAAWNARLIEGPESYAGRVRQYRTSLSNLVDQLREVAKQYGFTEDEVVSAMGVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAW3</accession>
    <name>A0A7W7TAW3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11592" checksum="5EFC90A25174F0E7" modified="2021-06-02" version="1">MSAPPYELLYTAEVSAVLAELQGKQQYAKKLKKIRKALAQLETLGPRYPALRSHPYQSVPGPNGTQLWESYVENNTPSAWRIWWIYGLKEDQITIVTIGPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBE9</accession>
    <name>A0A7W7TBE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="10013" checksum="C6728C032069354F" modified="2021-06-02" version="1">MPVAKFNAEALEQCRSAASAQAGQFGSVGDGLSGAYVDAGVFGKLGTSGGLASAVSDFQSRAGAECAAAEKLLGQVERAIDKVESAVDDVEAANAGSFRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTE0</accession>
    <name>A0A7W7WTE0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 10">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_000454</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="11">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27529" checksum="369937511738C560" modified="2021-06-02" version="1">MTAENTTPEALAAARLRERTGVDSHDIAVILGSGWRPAADLVGDPASEVAMADLPGFAAPTAFGHGGTIRSVPVAGKNVLVMLGRTHGYEGKGIEKVVHNVRTAAAAGVKTVVLTNAAGGLRQGMTVGQPVLISDHLNLTASSPLVGARFVDLTDLYSPRLRALSREIDPTLEEGVYAGLPGPHFETPAEIRMLRTMGADLVGMSTVLEAIAARAEGVEVFGLSLVTNLAAGITGEPLNHEEVLEAGRASASRMGTFLRALVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTF0</accession>
    <name>A0A7W7WTF0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10763" checksum="55FB42265414D527" modified="2021-06-02" version="1">MHELIEARRHEIVELRREVGVRRLAVFGSAVDGSFDVTSSDVDVTVEFAVRPGFDHVGNYFSLKEGLEAIFGRPVDLVGESGIRNPYFRQRVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP4</accession>
    <name>A0A7W7WTP4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="83"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="38316" checksum="B3DE6274DB5ACB20" modified="2021-06-02" version="1">MNAVWKTVGWVGGIVGAAATGVAVGVAAHHKRVNHDRGIADPYADEPLGRLVPSRESTVAADDGVPLSVEEVDPEAGDAVLTVVYVHGFALDRRCWHFQRRDLAGLVDPPVRQVLYDQRGHGRSGQPGPEGGTIEQCAADLDAVLRSVAPDGPLVLVGHSMGGMTIMALAERRPELFAERVRGVALVGTAAGAVGGAGLPKSVLSRYNPVTLGVGRLAGLQPGVVEWVRRRADLLTWSGIRALAFGDRDVGASLVDLMAEMINGVSVRVLTGFLETLGTHDRYKALAGLKHCEVLVISGDADRLTPFSHAERMAEEMPHGELVRVEGAGHMVMLERPGLVDEHLIGLVRRSAAERVEGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU08</accession>
    <name>A0A7W7WU08_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase (APT) family kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23935" checksum="5A3A2611A0297CCF" modified="2021-06-02" version="1">MNALTHGYTNLTEQRGSVVRKSYLGPDAEARRRTERSVLVELRDRFPVPPLSPGTERDLRTAYVRGVPGRVAVDAGLAERVLALCGRLRRELDALDVPGLPGTGAVVHGDFGPQNLIVTPTADAAVAVVDWEWCRRGDPVDDLAWAEWTVRLHHPDAIAAVDALYAAYGRRAKWSVRHEAMMATCHRNRDFCARGGDCAGVAVWDDRIARTAGFRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU39</accession>
    <name>A0A7W7WU39_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Drug/metabolite transporter (DMT)-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11314" checksum="24D4F932DAA63E84" modified="2021-06-02" version="1">MDTRSIETIQRNRRITWGGGLSIGIGLIGLPLVLFGVWPGLDHSPWNANTLVLALGVALCTVSYILGRISVAAVTHNRVAPPTRRPFVVAGVAFAVAVLCLLITLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU73</accession>
    <name>A0A7W7WU73_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="11959" checksum="2CE783C095A1ECEA" modified="2021-06-02" version="1">MPRTTLVANVVPAYVMPAAMSYASALALDDHRLAAASLTTIAVPSALAALAVTFAPRGGRRVVRMLLAAVLCAGLAFAASLALVHTGLAAPTLFLDAVPSAALGGVITAARTYRKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT0</accession>
    <name>A0A7W7WUT0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21183" checksum="60F70ED3935467A6" modified="2021-06-02" version="1">MSEPTAVDDESGLPDLADDEEFAGAVESVLLVVDSPVSEEQLASVFEQPVRRVTATLRRLSADYTARGSGIDLRRIGDGWRFHTRDRFAPFVEKLLLDGQRAKLTRAALETLAVIAYRQPVTRARVAAVRGVNVDGVIRTLVARGLIAETGTDSDTGGILYRTTELFLERLGLASLDDLPPIAPLLPEVDAIDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW1</accession>
    <name>A0A7W7WUW1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_001621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="13">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="125"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="572"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="14">
        <location>
            <begin position="1529"/>
            <end position="1821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1821" mass="195482" checksum="E72E8EDF42D93023" modified="2021-06-02" version="1">MFSRVAIVNRGEAAMRLIHAVGELNGEGGPRIETVALYTDADSTATFVREADVAYCLGPAENRPYLDLAVLERALVETGADAAWVGWGFVAEDPAFAELCARLGITFIGPDAEAMRKLGDKIGAKLIAEEVGVPVAPWSRGPVETLDAALEAAQRIGYPLMLKATAGGGGRGIRLVTGPDELTDAYERTSLEAERAFGSGVVFLERLVTGARHVEVQVIADGQGTAWALGVRDCSVQRRNQKIIEESASPVLSAEQADELKAAAERLTLAVGYRGAGTVEFLYHPGDKLFAFLEVNTRLQVEHPITEITTDTDLVKAQLHVAAGGRLTGPKPAESGHAVEARLNAEDPDRDFAPAPGRIALLDLPAGPGIRVDTGVSEGDEIPSHFDSMIAKIIAYGRTRDEALGRLRRAMRETTVLIEGGATNKSFVLDLLDQPEVIDGSADTGWIDRVRGEGRLASQRHSGVALAAAAIEAYEDGKRVELRRLLTTANGGRPQVQHEVGRAIDLSLRGAPYRLTVAETGPGRYRVGFVDGDDVRTVEAALERFDEHTGRIVVDGTRFRLVTGTHGTVHLVEVDGVTHRVSRDEGGVVRSPAPALVVATPVAAGDEVEAGAPVLVLESMKMETVLRAPARSLVRECVVSVGSQVGAGAPLLRLEPLDDAEDDTAAAAEAVDLDLPVAGTLSAADRVARGLADLRAALLGFDVDPVDAARTAKAYQEARAELPHRPLAAEVGLLDVFADLAELTRNKPDGAEDTWASSPREHFHTYLQSLDAERAGLSEAFQGRLTRVLAHYGVDGLDRTPALEEAVFRIFLAQRRASSDAAVVIGLLRRWLTEAPPGGELRQVVGQALERLVVATQLRFPVLGDLARSVVFRWFAQPLLRRKRAEVYTRVRRHLRHLDRHPDAADRDERIADMVSSPEPLVRLLGRRIDRPGLDGGPLLEVLCRRYYREYGLTDVRCEPVAGRPFVTGAYELDGRPQRLLATIADIADLPAALAGIAGLAGAAEESTALVVDVYLTWVDRPADVDVLAAELRETLSATALPGRLRRLTVTVAEGDGGVGHHHFTFRPSSTGLTEERLIRGLHPLVGQRLQLWRLRHFDLTRLPSVDEDVHLLRCVAPKNPADERLVAMAQVRDLTPLSDSEGRILALPAVEGALAACLDAIRKVQAQRPATKRLDTNRVVLYVWPASDLAADDLASVAQRVLPTTAGAGIEEVLFLGRRKEDGRVTPIAVRLTFDATTGVRIEVTEPPAEPVQPLDDYGQKVLRARRRGTVYPYELTDMIAGPGGSFTEYDLTDSAVLAPAERAKGLNKAGIVVGVATTPTTRYPEGMTRVVLLGDPTKALGALSEPECARVIAALDLAERLRVPVEWYALSAGARIAMDSGTENMDWIAAALKRIVHFTQDGGEINIVVAGINVGAQPYWNAEATMLMHTKGILVMTPDSAMVLTGKQSLDFSGGVSAEDNFGIGGHDRVMGPNGQAQYWAPDLRGAHGVLLAHYEHSYVLPGEEGPRLAGTTDPVDRDVSDFPHSAPDSDFTTVGQIFSRETNPDRKKPFDIRAVMRAVADQDHPVLERWAGMADAETAVVQDVHLGGRPVCLLGIESRSVQRRGFPPTDGPDTYTAGTLFPRSSKKVARAINAASGNRPVVVLANLSGFDGSPESMRKLQLEYGAEIGRAIVNFEGPIVFCVISRYHGGAFVVFSKALNPNMTVLAVDGSYASVLGGAPAAAVVFAGDVNARTAADPRVTELEERVAAAAGTERAALVARLADVRTSVRAEKLGEVATEFDGVHSIQRAQRVGSVDAIIRPQELRPSIVAAVENGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ8</accession>
    <name>A0A7W7WVJ8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="11" type="ORF">F4559_001967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="10">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="658" mass="69611" checksum="BCC43D6EDFECF81E" modified="2021-06-02" version="1">MVTTRRGERVPATSLPVARICVDVPLAHLDRPFDYQVSTEQDAAAVPGCRVRVRFAGQLVDGFLLDRVASSDYGRKLTFLDRVLSPEPVLAPEILELARVVADRYAGSLTDVLRLAVPPRHARTEAKESVPAPVPVPPAVDGWARYPFGPNLLDALSSGRTARAVWQALPFEDWPARLAEAAVTVAAGGRGALIVVPDHRDLARLEAACSALAEGAVALAADLGPAERYRRWLAVRRGAARIVLGTRGAAFAPVADLGLVVVWDDGDDLHVEPRMPYPNVRDVLVQRAHQSGASLVVGGFARTAEAQVLVDSGWAHEVVAARETLRSAAPRVVAVGDSDWQETRDPAARSARLPSIAFDAARFAFSHDAPVLVQVPRRGYVPALACGQCRAPARCRRCAGPLALPGGTDDGRPRPAHCRWCGATEAAFRCGTCGSRRLRGQVIGARRTAEELGRAFSGVPVRTSGGDEVLASVPGGAALVVATPGAEPVAAGGYGAALLLDGWALLGRADLRASEEALRRWMTAAALVRPGSADGRVVVIADSALAPVQALARWDPVWHARRELAGRAELGFPPAVRMATVDGAPDALAAALDDLVLPPTGEVLGPVPLGEDRERALVRVARTEGRALAAVLGDLLSVRSARKEPEVLRVKLDPLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM4</accession>
    <name>A0A7W7WVM4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12325" checksum="0933C29E140C7DF5" modified="2021-06-02" version="1">MAQKTIVELIDDLDGTTADESVTFGLDGVEYAIDLSSDNATRLRDSLAPFVAGARRAGGRKQRATSRTAVKAGGDREQNQAIREWARQEGHEVSERGRIPQSLLLKFQEAHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN5</accession>
    <name>A0A7W7WVN5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6788" checksum="7CF457A5FA925548" modified="2021-06-02" version="1">MDSKEQKEVRNGDIHKGPALCVLTSEDRWASVTLTNRYVENGATESDVRIVVGKRADERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ5</accession>
    <name>A0A7W7WVQ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="40026" checksum="EF73CDD44E40EFBD" modified="2021-06-02" version="1">MIPSSVPDEAASVALIGIDLADGRWCAALDRAFLLPGLPVRDRHDPARRLGIIAHTLACAGRASGARHYTALACQALPGGGDQLRWIAASLGVPSRAGCDRTAPVRQGTSRSRGIGIDAARAVGRAEEALAWLDHTATRSPRADAWARMVSWCEARDSARLDGVHAALLEFLHRDLPPSGNHPVFIDPDLVPYLAPPADVTRSPPDDLVDIAGRHFLRRSTTPHTELAADLSRHLSGPWLPIQGALADRHRAVDTATEVEPFTRLIADATTAACHTAVNALHDLDLLYRRLTTRLPSGRLSRLALRDLFTQGLVTAPALARRHPMCAKSAHNVLDRFLDLGLAVPYDHRHYARAVYNPDLIDLLTRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS6</accession>
    <name>A0A7W7WVS6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="31957" checksum="0BE936DFBBC0E780" modified="2021-06-02" version="1">MHLGIHVIQFLSPDGNRGIAPELAKVARAVEASGATRLTVMDHYFQMEAFKPATDPMLEGYTTLGFLAAHTSTVRLGLLVTGVTYRHPGLLAKIVTTLDVLSGGRAELGIGAGWYEREHLGLGVPYPSTAERFERLDEAIRVCLQMWDPDNDGAFEGKHYRLAETLCSPQPIRRPPIMIGGGGEKKTLRLVARYGDACNLFAGDKDVVRHKLDVLRGHCDAVGRDYATIEKTLAYSQTPQLEDVDGLLRDLEDYAALGIETVILYPPADEPAAWVEKVGTPLAARLKEIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT5</accession>
    <name>A0A7W7WVT5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CdiI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040509">
        <property type="entry name" value="CdiI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18228">
        <property type="entry name" value="CdiI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdiI_N" evidence="1">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16604" checksum="CDE7EA0C0A774432" modified="2021-06-02" version="1">MFAIEVEDSSDAAGVAGGSSSALGWIKIDDFVEWFRAPIGFWVESDYRRSWREAYLRLEISIDSTSCLLVSVTDPAVSNFLTCWPMYRDGEKVYLQNSLIFLGEVGPDFDISRPWCHVLPRAVVNEDGMRISEWATSMDSIREFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW20</accession>
    <name>A0A7W7WW20_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031228671" evidence="1">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="20098" checksum="0FD9C7961BF81DE3" modified="2021-06-02" version="1">MHPLRNSLAIATCLLTAVALTACGTTDTPKTTGGPSTTSPASATVLAQGEIPGSAAASATAAPVTGTSVAATPTGRLKYGESMGYALPETKDWDTALEVRVTDLAATRGEPAGTFEIGIANRTGSPFDLAGLQVRAVSDGKTVAELKRDPGNEALFKTLASPAVVTGSITLPVEAGKVEIWVQPSPTATEITSWSTNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK3</accession>
    <name>A0A7W7WWK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="956" mass="105501" checksum="CF8AEB861B962721" modified="2021-06-02" version="1">MPPRPSPTRQPQAPPPRSSRPTDRGRLPETSADSGEATRRHTEAYGGRAAFDLGTTTATVTVWDPQEATYPSLSPVQRRTLAEAFADLLDDHPAGTELSVAWRKFDEHLAEVLDPASDGTSAAGRLRHKDGHQAVLERVIVELERFRESGGRDVRRYLTPRLADCYARALAVPPLDSLRYYRAYLEGRAHDELPSVVWDTGAPDERRFRLGDPPEARDPVAYRGLKQQLGRHTPRLFGPEDGPAYDELMTGALRDLVYRTNRYLENFRTELALVPGRLVDAVVTYPTMASLSVRDTLRRMLRDVGILAPDTRFDEAVAAAMFYVLRSVGGRTDLAVEAFASRCDPVPGEKLTPDGRPTAWRQNVLIVDVGGGTVDVALIRLDLRDETDRSRPGADSPHYGRYFRLRPTLLGTTGESQRGGDFLTLQVFRWIKVLLADHLLTHRSGVAEAVRDQLGRRYYDAHDGYLPGKLVTSALESLADLRESARAAGHVVSTEWRDTTPGKPGTAAEREQLFGLLWTMAERVKKDLGTAESVAVDEIPLRTVFDAVCEMHSSSADGPLEAPRFLLRQRDFTRLVAPEVRQSLEPAADLVAARLAGDTLHQVVLTGRGSLLPLVRSELVRALADRRTGTEPVPPILGYGDEYAKHAASIGACWAATVDRRGQEHVLKRLAEGVTWLTVEVDNLLRSMRAAFVVPPNMAGSMAAIPLFGMDSELLPTEAGGEPVVRSDWVQYQNPFRVDRVKGVERSVQWTNLRLQEYYRRVLHRAEEDDLFVQVEAAASLEMWALVCRGGVPDIELPVHRESIPFLTAPFDAVPVDVLADPAIGGFLDDSRTEPVFRRDEPLDQVIVVGGERLRGRVGGPLDAPQAHGWRFYRSDGAGTDSHPVTVAAPPCAPGLRHYAVLDERGVLHVVAGPPPYRRADDLDAVLDSPGSVLRLVMTSAEPDYRAEDDPFTGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL1</accession>
    <name>A0A7W7WWL1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="23564" checksum="33334F61F2FF0FE2" modified="2021-06-02" version="1">MGTRVLLVKLDGVLALRESWARPDEPILLCVGITPATVRYDAAGLDWWGKPARGALGTVAGGPGTAVFAAADAASGGAGPGDGGADAPAVVVWGRGPETLASRACRASARSWLVLTPHRLACVAAPAGPSVPEPEKKLFDRVAGFAKSPLSDPLFPPHDHVETVPITTVAEMSRERISRVALAERALPRGTRPRDVAVLRLSLVDGSGVDVVAAGGPEQARRLLSLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ3</accession>
    <name>A0A7W7WWQ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030563336" evidence="3">
        <location>
            <begin position="22"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="38123" checksum="771866090D4D348C" modified="2021-06-02" version="1">MAGRWLRTVPLLVLAYVVAPAATLTVARWTAPWPRSAAEPGAALGLAAPALSPGHLPALAVGLVLFALAWWRTSTWPLIALVPMAPLVMSGVGFGSGQALITLVGAGLAWGTAWLAGRAVSRPVTAAVGGSAVEIVIGLRGGARLRVQSRRLLLDRLPAPNTAGMPTRLALPLDRVEFVQAGGVAGGPTPWQLPNSAVLLVPPGPVVRIVGGGQQWLLPVDDADAVAAALTRRVAVRARPRPAPPEDSGRWHLAKTAWKSGPAAPRRGATPVPHRAGSAHGRHLRLVVGALMVVMGGYSTTRLFAGAGLGHLFGVLLFGVAGLVTMATWYGGEAAHRLAEENPRPRTAPGWGETDPAAAPVPGWLTHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX6</accession>
    <name>A0A7W7WWX6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="36" mass="3885" checksum="A8F317213C238004" modified="2021-06-02" version="1">MVYRVIAAGAVWIVVGGTAVVVPDIDHVLSCECRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ6</accession>
    <name>A0A7W7WWZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Steroid delta-isomerase-like uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="PTHR38436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="15167" checksum="47F2AC4CE9A21D9B" modified="2021-06-02" version="1">MSIEVNKEVARRYYEEFVNKRRLDLVDEIIAEDAVDEAAGIGGAGREAFRQHATWLWETVEDVQTTITDLIAEGDRVVVYWRMDGIHRGTMFGVPGTGRRFIGHSVSLITFRDGQVVRYSVLPDRLGIIQQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX47</accession>
    <name>A0A7W7WX47_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20789" checksum="C47E98A313BFC30C" modified="2021-06-02" version="1">MRGPRSFRLAGEIADGVHHALSYTYRAYRYLVDNVRIGAERAGRDWRTLDIGAWVVFAVGHDGEAAKRAARAVVALYASSMSDERLMRNGVDPGSLAEAVAAVGAGDLRRAYDLTPVEVAQRLSVAGTPAECVGKIADEIARAGVDHLILAVTDADLVRVLCGLELPGVLGVRDQLRLVHKHVMPAFDRHGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN0</accession>
    <name>A0A7W7WXN0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="41341" checksum="2FF6B16E1CAF1D36" modified="2021-06-02" version="1">MGKPAVVWNPSFLGYDLGGDHPLNAVRLDLTIRLATGLGVLDGVDLVAPEPAADADIERVHDAGYLAAVRAAPVSGWDVGHGLGTADNPVFARMHEASALVVGGSLAAARRIADGSACRAVNIAGGLHHAMRDHAAGFCVYNDCAVAISWLLDNGFDRIAYLDVDVHHGDGVQAAFYDDPRVLTVSLHQSPFSLWPGTGLPAESGAAGAEGTAVNLALPPGTRDQAWLRAFDAVVPSLLRTFRPQVLVTQCGVDTHREDPLADLALSVDGHAAVYRRFRDLAEEVAEGRWLALGGGGYELIRVVPRSWTHLLATVLDRDLDPDTPVPADWVDHVARLAPDRRLPASMTDGAPTDVTAWGGVTTDAVDAAVRDTRHAVFPLHGLDPDDPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ4</accession>
    <name>A0A7W7WXQ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LysW-gamma-L-lysine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="610" mass="64604" checksum="F0953E67E3F6CA1F" modified="2021-06-02" version="1">MKIGSASLRHDTVFDELAGIPLRGARVLLVAGGAAGIVEHYESIGRDIRFLRLRNGDDVRYCPPEEMAHIVEAYRRVTLPRVRQALATRGIIAYTAPAADDALVCGTANPPIRAVSDGRVTVVRDHRAGVVSGVDVERILSLLEAFDVVCLSPPVSDSAGGSALNVDADVLAAELANALDADHLRLVTGTPGLLADPTDPTSRQEHVLPGEGGQYASGRMKQKVRAAEIALTGAADVAITGPHVLAPASGTRFWRATPPADDLNLLTRTVELSSVSADERELADYLVDWCTEHGVDSGIDQAGNFVAVRGSGARRLLLLGHLDTVAHRWPARWSNDEVLHGRGTVDAKGSLAAFLETLVEADVPAGTQLRVVGAVEEEMTSAGAFFVRDNYPADAVIVGEPSGAGALTISYRGLLKIRLTVRTPVGHTAGHGVVTAADQLVDVVARLRAAIAEYSPEAMMAVLGLDARNGGDVQLGEAVFDVRVPHTTDVHALAALVERVAEPVRTTVLRATPGHATPRTSPLVRAFSPAFRAAGVTPRYLAKKGSSDMNTLATTWRDVPMVAYGPGDASLDHTPQEHITAAEFRLSRKVLSAAVTHWLTRTDHPTTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX6</accession>
    <name>A0A7W7WXX6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X/cobalt-precorrin-8 methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.60</ecNumber>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.60" evidence="6"/>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043778">
        <property type="term" value="F:cobalt-precorrin-8 methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="21646" checksum="12C7D3E0ACD5D968" modified="2021-06-02" version="1">MTDYVRDGAEIYRRSFATIRAEADLSGLPDDVARVAVRMIHACGMVDLVADLAYSPDVVATARAALLAGAPILCDAKMVAAGVTRRRLPNDNEVLCALDDPRVPDLARELGNTRSVAALDLLADRFAGAVVAIGNAPTALFHLLDLIRAGAPKPAAVLGVPVGFIGAAESKEALADNDLGLEYLVVRGRRGGSAMTAAALNAIASEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY81</accession>
    <name>A0A7W7WY81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32272" checksum="70E49AD8533E0FD8" modified="2021-06-02" version="1">MIEVRGLTRRYGDVLAVDDLTFTVEPGAVTGFLGPNGAGKSTTMRIVLGLDRATSGTALVGGRAYASFPAPLHEVGALLDPGAVHPGRTGRDHLRIAARTNAIPTRRVDEVIERAGLGQAARRRIKGYSLGMRQRLGIAAALLGDPKVLLFDEPVNGLDLDGVRWIRGLLRQLADEGRTVLVSSHLLSEMQQIADRLVVVGRGKLIADTTTERILGGLGHVRVVSPEAANFEKVLVDKGFVVHRDGEELRVENSGADHVGTVAHESRILLHHLSEVRQSLEDAYLDLTDDSVEYRGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH6</accession>
    <name>A0A7W7WYH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family leucine-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17614" checksum="21F5C89A22A1CAA2" modified="2021-06-02" version="1">MELDDVDWKLLEILQTDGRITFTELARRVSLSAPATTERVRRLEQAGVLTGYVAVVDHRRLGLPIEAIVRVRVRSLDTPRFRERVVPLAQVRDADHVTGDDCWLLRVVCRSTQELEEFVEHAQRFGDTTTSLVFSSPVRTRPVTRETSDGIVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYI0</accession>
    <name>A0A7W7WYI0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein with PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="48188" checksum="F80A8DDE15C21D26" modified="2021-06-02" version="1">MQDPITPLDTADDAVSEDDPVGESAVDWAGLPEPLRVRLAELSADALGELAKVDVPQSLRAVARFAPTKRARLGASALLGGLRGSANFRAAVVEWLRRNRPATLETTSPDPVTAGAAAILQGEEVAAHFVELVGRRASDASLRAERDTAVLRAERLESELDRLRTERAEVGGAADKIREEAEVELERLRKRLREQGVRLREAKDRAEAAAAEVEKVRALTDAEVRRVTAERDRERERAENERAKAQRAVADADVARQSAKEARQADEVRLALLVDTLDGAVNGLRRELALGGAGPRPADLVRGASAAQGAVGRVEDPAALDRLLALPAVHLIVDGYNVTKTGYPELSLSDQRDRLVHQLAVLAARTGAEVTLVFDGAGVVAVPTSAPRGVRVLFSDPGVLADDVIRALVTAEPEGRPVVVVTSDRAVADSVRRRGAHPVPSAVLLARLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYI3</accession>
    <name>A0A7W7WYI3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22842" checksum="BA349C314135E5DA" modified="2021-06-02" version="1">MEPISVTALSFTEYAMSGQRGRISIVTEQRSIYLATDPWPCGFYNPMRNAMRRAANSTDPDAELDRAVESAHLNGQERAFLELREGFMPWLRTTRATGVPVAPTRWRAGDLVLKVRPHLGLRLPDGSLGAVLVYMKEAPMSQEAANVGLRILEQTMTDTLPGATALVLDARRGRAFRMAKRTNRTKLDALIAAEAAGYVVHWRMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL6</accession>
    <name>A0A7W7WYL6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease BN (tRNA processing enzyme)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="27560" checksum="5FCE474A3E4E3293" modified="2021-06-02" version="1">MLLTILGCSGSLPGPDAPSSGYLVEADGFSLAVDFGSGVLAALQAHRDPFALGAVLFSHLHPDHCGDFSGLTVLRRYHPDPPYDPTTRPLPVYGPGESPDRFARAYAESAEELARTDLTDIYRFHAVSDGGTVRIGPFEVTSRRVAHPCEAYGFRITTPEASLAYTGDTGPCEALHELADGVDVLLSEATWEHAEDRPADLHMSGRQAGRLAAAAGVGRLLLTHVAPWTDARVVLAEAREEFDGPVEPAARGKSYRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT1</accession>
    <name>A0A7W7WYT1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FhuF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="28585" checksum="D732895B15818470" modified="2021-06-02" version="1">MTVPTKVTARDARSPVADTLAGVAHAAGTFEVRHGLPEQRDGWVTSAELFTEPDRFTAWRDLLADWLRAEYGSAPERTTAGYVMGWYLNVVGLAGGLLFHAARRVPSLRPDDVAVRIAGTGRPHLVGVALLAEGFACLAEDPASDHADATVVGCERALADLMRARFAAHAAAFVSAYGPTVRLGRRTLWAGATDALDSAAWTAGRLLGDETSGVADAALLLPAKLEPFTSATTLRTVDGEWTRRRESCCFHYVLPGAQECVTCPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYZ2</accession>
    <name>A0A7W7WYZ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+-hydroxamate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="36"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="27382" checksum="AA861EF4BA27F779" modified="2021-06-02" version="1">MIPVDDLDAPVVLPTRPTRVVSLVPSLTEAVAGHGLVGATDYCTHPADLDVVRVGGSKYPKVDRVRALRPDLVIANSEENRPEDVAALRADGIPVWVTAAPATVPAALASLRRLFGTVWDEEPAWLTAAEDLWRDVPPPRATAIVPVWRKPWVVLGRDTFAGDVLRRLGVVNAFAGHPDRYPRPDRDELAAVEADLVVLPDEPYVFTPEDGPRFFPRQRPVHVNGRHLTWYGPALVEARDSLGSALAGTGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ29</accession>
    <name>A0A7W7WZ29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase (EEP) superfamily protein YafD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35466" checksum="E50DC90ACC539307" modified="2021-06-02" version="1">MNRRRVGSWALGAAAGLFVVFGGVRLLGIDGGQHLLALTSLTPYVLIVGIVLGVIALVVRKWVVAAVTLLLSAVLVGAVVPRAFADGAERVDGREVRIMSANLMVGKAVAEDVVRVVASQDVDILTMQELTPAMVKDFERAGLDRFLPYRVFLDEPGGSGSGIASRHPLTRKDLTGPSTMRQAGAVVDLPGTDVEILSVHPLPPVVGDSAEHWQRDMDGLPRRDSARRDSARRDSAGPIRILAGDFNATLDHAGLRRLLDSGYVDAADRTGHGLTPTWPADGSWLPPVTIDHVLADDRCQVLDYAVFDIADTDHRAIVSRLVVPSAPGRPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ30</accession>
    <name>A0A7W7WZ30_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LuxE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047474">
        <property type="term" value="F:long-chain fatty acid luciferin component ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007534">
        <property type="entry name" value="LuxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04443">
        <property type="entry name" value="LuxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="26"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="359" mass="39711" checksum="9C5148B4F5F5DEE4" modified="2021-06-02" version="1">MTDTVFGLDQSAREAALLPALTELTAHHREHCAPYDRILSSLGTPTRFDAVADLPWLPVRMFKHHVLKSVPDDEVFKVLTSSGTTGAEVSRIYLDRDAAGDQPRYLGRTLRTVLGDQRLPMLMVDTIGIIKNRRSFSARGAGVLGMANFGRKHVYALDEQDRPDVEAIKGFLREYGDQPFLIFGFTFMVWQYLYEVAVEHGLDLSNGILIHSGGWKKLIDRAVDNAEFRRRFANDTGLRRIHNYYGMVEQLGTVFLEGPSGNSLYCPDFADVIIRDPETWAEQPVGVPGVIEVVSTVPRSYPGHVLLTEDLGVVHGIDDGDWPGKRFSVLGRLPRAEARGCSDTFSGDAAPRVPAGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZF4</accession>
    <name>A0A7W7WZF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031138052" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12317" checksum="A8EAB56971D93B99" modified="2021-06-02" version="1">MKLLRLLPLVALVFLLVGCSSEWEGDVRFKVTKLNPGFTSSVQVQAPYANLEIDEAEPKSTLEPVSKKAVDISDLPEGVQVGDVVICHVSQHDKSGFDQQGVQVKLDQCRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZH5</accession>
    <name>A0A7W7WZH5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multiple sugar transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031423760" evidence="1">
        <location>
            <begin position="32"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="440" mass="47341" checksum="D8DDCBBCD584AF7A" modified="2021-06-02" version="1">MRKISRAALLCVAAAVSLTACAAGAGNNNTAATTAPGKDDKFSLTVWSNFSGREQDELTKALDSFKKKYPNAEIKHEGSQDDDKITAGIRGGNPPDVALSFTTDNIGQFCSSGTFQDLKPFIERDKVDLGQIPDAVRSYTEYKGQRCALPVLSDVYGLYYNKDILAAAGITTPPKTIAELVDFAKRTTKKAADGSIEVAGFLPSPQFYENRAQMLAPAFGAKWFGADGKSSLSTPEWQDMYKFQKELVDFYGYDNLERFRAGLGQEYSADHAFHQQKIAMMIDGEYRTAFLKDQAPTVKYGTAPVPTAKPDLYGTGLTTGTIVGIPKGAKNPAASWELIKHLGFDTDAIVGLSNGLKNIPHTKAALADPKLEVDENFKTFIDLAAGGKLQGNVSTPIGDAHIKAVGDFSSSWQAGAVPDLVAGLKEIDKQIDDQIAKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZT3</accession>
    <name>A0A7W7WZT3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein implicated in regulation of membrane protease activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="6916" checksum="1195D367860F7CC8" modified="2021-06-02" version="1">MGFLAGLLVIAVAAALLIEEVLYLLGGSLWLYAAAVIVVVLVVLVGGPSARARRRIRRDEEVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZT8</accession>
    <name>A0A7W7WZT8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="6745" checksum="EB4E5F78666E3DE3" modified="2021-06-02" version="1">MPSVDLSGAEWRKSSRSTGGTNANCVEVAPVGPVVAVRDSKNPQGTPLAFPAVQWAFFLERLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXU8</accession>
    <name>A0A7W7SXU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA threonylcarbamoyl adenosine modification protein YeaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="37"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="22898" checksum="4DB2874FFBEC1C86" modified="2021-06-02" version="1">MFVLALDTATPAVTAGAVELTADGPRLIAQRVTVDPKAHGELLTPHLLEALAEAGLVFPDLDAIVVGSGPGPFTGLRVGLVTAAALGQALNRPVYPVPTTDAIALAAHTGQPLLVATDARRREVYWAAYDAAGRRTDGPHVESPADLVAKLPALGVAHATGQGAELYDLGLPVLDTRYPTPDALVKAAAADLLAGARPAALTPLYLRRPDAVAPTGRKRVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXZ6</accession>
    <name>A0A7W7SXZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019238">
        <property type="entry name" value="AbiEi_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09952">
        <property type="entry name" value="AbiEi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="38106" checksum="A4876F04F10C47B7" modified="2021-06-02" version="1">MFNENEHGRKLNESTRLSELRAWLSPLGLKVDMEPGGHASDHRIDMVVRVSRASGAARTYAVEIKRDVPPAMATALHPHASLPTLVVARWITEQAAGLMRERGIDYVDEAGNAHIAWGDVLVDVRGRRKTGSRGGGSLPRGTKAFSRAGLQVGFVLLSWPSMAGAPLRALASASGVSLGTAQAAVEDLAKAGYLYEVADKRQLGRAGELLNRWSEAYSTRLSPTLSLGDFAGSDISWWRGSEDELTRIDVQVGGEAGASVLDPHLIPATLTLYAEDRPRSLIGEHRLTLAGEVGNVHMRRRFWTMPRQSWIVPPTLIYADLLASGDSRQREHADRIRISDDRLAGLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH5</accession>
    <name>A0A7W7SYH5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="6093" checksum="374C3FA8AEA35C49" modified="2021-06-02" version="1">MAGFGQQRRRRHAVVVLVESTDVLLQLGDGDEIDRARMPQRSHYAVLGLRAFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYM7</accession>
    <name>A0A7W7SYM7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_000131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4962772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34860" checksum="59846F2DC6EC462A" modified="2021-06-02" version="1">MFPAHRPRRLRTTAALRRLVSETTVRPRQLVLPMFVKEGASAPVEIKSMPGVLQHTRDSLRKAAVEAVRAGVGGLMLFGVPAERDAVGSGATDPDGILNVALEDLRAELGDDTVLMSDCCLDEFTDHGHCGVLTPTGQVDNDATLEVYGEMAVAQARAGAHVVGPSGMMDGQIGFIRSALDEAGFADTGILAYSAKYASALYGPFRDAVESQLQGDRKTYQQDPANGREALREVELDLAEGADMVMVKPALPYLDVLAEVARLSTVPVAAYQISGEYAMVEAAAANGWIDRRRTVLETLTSIRRAGADIVLTYWAAEAAGWLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS6</accession>
    <name>A0A7W7SYS6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="930"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="996" mass="103050" checksum="F137CA603DDF8A30" modified="2021-06-02" version="1">MGAVRGPLGRERELDRLRARVDDLVRGHGAALVVEGEPGIGKTTLVRAACAYAATLGLRVCTGAGDELDRVIPLSPLLDALGSTRSQTIAATVEHLVDRVDELCAEGPVMLVVDDLQWADDATVAVWRRLVPLVSQAPLLLVGVVRPLPRRDLIRSDVTRLTLSALDEAAVRDLVASLAGGVPDDRLAALARGAGGNPLYLVELVESLLRGGSLVVSDGVATVTGEGVPASLAAAINSRIGFLSADVRHVLVAAAVLGVRFAVADLAAVSGRSVVDLLPALQDATVAGVLDDGAVLSFRHPLVRAALYEQVPEAARCAWHAEAARALVDAGAGVDRVTRQLLAAGELPAWTAPWLLEHGGTLVAHAPEAAVDLLARVVESSCATERIRLLAHLAEARFRLGDHAGAEAVALAGLASGMSVDLHWTLAQCRSLTGRSARTLAEVDRALRADSPTPAERARLYVLAARAHWDLGDLDAAARLADLAVGDGDPERRGRGMAEAGPAGAGPWAPGVAGAVGVVGPGAVGVGSAAVAGSDGSGVDSAGTGSAVVAGSGPVGVGPSRSVVGSGVVGPVGVRSDGPVVGGLAPAGAGAGSVPVVQGGGRSATAVADPGTVAWALHVRMIVAMARGRMVEALSLADRALAVTMGDPATADLRLLLQVNRAVTLGESDRGEEAVRAAREVRRQADRAGNVVRLAQVQSALGQLLFDAGRWDEALLEVDLLPDDLKHPMVSRCDHGVAASIHLHRNEVDAAAGHLRAALPDGHVVGSLALATSVDLERKGHVRDALGVLRVGVDEVEDLLPDAARLAVELGEDPAFAVRRADELLAGSDVPHRRAAAEFCRAIADDDPEGFLRAAREYRAAGRPLFRAKALGLAAVRLAVAGDRTSARVALSKALDVYGELGAEWDAAVLLGRMREHGVRRGAHAKHRRAKHGWDSLTPMERKVTDLVVTGLSNRQIGDRLFLSGRTVATHVSHVLAKLGVRSRTDIAREAVRHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT1</accession>
    <name>A0A7W7SYT1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="10" type="ORF">F4559_000221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="8">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="27801" checksum="386A1AF29EFAF540" modified="2021-06-02" version="1">MTSDNGVDTRELADLTDERDLGATEADVDQADEAAEDTEEPAPASTQSVDLDEEPIDAAAEMREALRRAPGDWYVVHSYAGYENKVKANLETRIQTLDMEDYIFQVEVPTEEVTEIKNGQRKQVQRKVLPGYILVRMELNDPSWSAVRNTPGVTGFVGATSKPSPLTIDDVLKFLLPQGEQKPAAGKKATSTPVKTAVEVDFEVGESVTVMDGPFATLPATISEVNADGQKLKVLVSIFGRETPVELSFSQVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW5</accession>
    <name>A0A7W7SYW5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14016" checksum="BED0FF0BAFB29D9C" modified="2021-06-02" version="1">MPDDRIGEYRLRRRHAGVGYFGQVRVRLTAVGEGTSPVTWEVDPDDGSSLQPGPDREFVDAAVAGAGDGLDLVTGCGVDPAGAAVEVVHAQLDLTDIEVSAVRTAAALAVADAFGVADRLRPVFRQGWTVDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ35</accession>
    <name>A0A7W7SZ35_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme O synthase-like polyprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="20198" checksum="06EE0FD91DA13021" modified="2021-06-02" version="1">MTNTEWAPESPAQRIDRNYHEILQEMRVAQTGVQLLLAFLLTLAFTPRFPLLTAFQLQVYVASLVLGACSTALLIAPAPFHRLVFRRRLKNELVRASSRLLLAGLVLLKLALAAALLLILDFVLGRAPAVTVTAMLLAWFCFWWYVVPLRYRSRSPRVAYGFPGDVRPRAHSEFRQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC1</accession>
    <name>A0A7W7SZC1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5287" checksum="984C33BAFE3A27DE" modified="2021-06-02" version="1">MTRQSWFARLLLGPLDGQDGPDPDCPRGGEPHPDVSDHDTTTDPEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZD3</accession>
    <name>A0A7W7SZD3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11622" checksum="8E8C6D37BC2D447B" modified="2021-06-02" version="1">MPYLVSVIDDKDDSGSTDRGPATSAFNERLIADGHRVFANGLADTDAATVVDNRGAEPVISDGPFVESKEYLAGVWVWEAPDLDVVLALATEASRICDRKIEVRPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ6</accession>
    <name>A0A7W7SZJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="37230" checksum="D0698916F39123B1" modified="2021-06-02" version="1">MVVTDAAHVPGLGVSRSGPMVLASLGRAGEALRWLDHVVRRSPWSSCWARTVLIREAWHAARLDGVPATLVEVLHHLLPRGHAVEADAGLFPHVRAAREAIAGLPKVVVPEPLERVLVSTDRRRLPWALTRAGLLSGPWLPFTGWLVDHPDALDGSDPATIALLADGIAETCHTEIALLDDLHHLHTRLLGRLPSPTRHHRTVLHDLAGRGMVNARDPATRHGTTDYGRSLYSPRRRRTPDREPAVTHTIRLRAVEFAKAMTLAGYRSDYALSQTMGLNRSTVTRVRTGHLNPGPAFIAGALIALAPMEFHDLFNVIHARPRRTASTSGTTGHPCHRPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS5</accession>
    <name>A0A7W7SZS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8233" checksum="C9FB2ED7284BADAE" modified="2021-06-02" version="1">MAHTIRLRGGAFTKAVQLAGFGSDYALSKAMEVNRSTVTRVRSGELQPGPAFIAGALVALSPMQFDDLFEVVHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0B9</accession>
    <name>A0A7W7T0B9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="23083" checksum="0DC2A124EF758CF2" modified="2021-06-02" version="1">MTEESVLRETQAAYDAVASLYAELFGDFLDAKPLERGFLAAFAELVRGPVADVGCGPGHLTAHLRSLGLDVYGVDLSGAMIGLARQAHPDLRFDEGSMTALDLADGVLGGILAFYSVIHTPPPHVPAVFAEFRRVLAPEGLVLLGFFAGDDPVPREFDHKVTPAYRWSPDRLAELSRDNGLVEVARLVREPDEGERFRQAMLLLRKTVDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J3</accession>
    <name>A0A7W7T0J3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septal ring factor EnvC (AmiA/AmiB activator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16236" checksum="013A9802A52C17C6" modified="2021-06-02" version="1">MTENAYPGLPPQGVPPQQGGFYTGPQQVQQPGVVPPPQQPAKGRTAVILLSVGIVLLLGASVLMAVLYFGANKDAEAEARRLDEVTTSLTEAKDKLQDTKKSSDEIANRITTLEGQNTELHKCGDVGKEVIRAARAGSDAELDAALKKVRTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L4</accession>
    <name>A0A7W7T0L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="21802" checksum="7F412AA1D9FDF987" modified="2021-06-02" version="1">MTRHEFSTVSSRDVHIGRVVGLRVDEVVMPGGGTASREVVEHLGAVAVAAVDDDGCVTLIHQYRHPLGKRIWELPAGLLDAAAEEPLEAARRELVEEVGLTASSWVTLVDVAASPGFTDEVVRVFLARGLESVERQVLGEEEADLEARQVPLDEAVAMALAGEIVNGAAVSGLLAAQAVLAGRARARPADAPFADRPTAFARRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V5</accession>
    <name>A0A7W7T0V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="34238" checksum="05DA381BBCDA4837" modified="2021-06-02" version="1">MHLELRHLHVVLTVAEAGSISRAASSLKIAQAGLTAQLRRIERGFGGPLFVRRSDGVELTELGRHVVLRSRDLVERFDDLLDTARLLATRSDGPGIRLGGVVGAPTALLVGVVRDLLPSHPRTTHVERGCDAVLDLVRTGKVDVALVTELPHSPLRVPAEVDRRSVVTEQMLVGVAPAHRLSTRSEIRLSELADEDWAVPEEYHGGGRLTLHLACEAAGFTPRFAHLGVDPEAAAELVRAGHAVACFFPFGGTIPGVALVPIAGNPVHRRVTLAWHRDCEAAEYADDIHAALLRAYHDRVCRTRTARLAATGLVVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z6</accession>
    <name>A0A7W7T0Z6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23695" checksum="919A0319C1E2D1F8" modified="2021-06-02" version="1">MRVLVVEDEALLAEAIAEGLRRESMAVDVCADGLRALESLAVHDYDVLVLDRDLPGVHGDDVCRSVVERGTVRVLMLTAAAEVADRVRGLGIGADDYLTKPFAFAELVARVRALGRRTTPALPPVLRAGDVEVDTARHQATRDGRFLPLSRKEFAVLEVLMRARGAVVSAEELLEKAWDAHVDPFTNAVRVTMGTLRRKLGVPPVIETVPGVGYRISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T105</accession>
    <name>A0A7W7T105_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15363" checksum="A3845F05686432DC" modified="2021-06-02" version="1">MRPFTRKTLLCLHVVSSVGWLGVTLGDLALGLAAYGDATLYRAVVVLADYALVPLGLVALVTGVVLALGTHWGLAKHWWVLIKLVLTVLALAATTFLLRSAVRDAAAGDPRGALDVVVASSVSLTVYVVSTVLSVFKPRARTRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T117</accession>
    <name>A0A7W7T117_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016540">
        <property type="entry name" value="UCP008459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008459">
        <property type="entry name" value="UCP008459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_7" evidence="1">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13441" checksum="D6D6B5D7B3A16F3D" modified="2021-06-02" version="1">MKRLVVEVRPGDYAIARLAADAPVPADVFEAPGLVSVTRTPDELSIVCPTTSVPAGADVVEGWRLLTVRDPLEFTLTGIMAALSGELAAAGVGLFALSTHDTDHLLVRASDLGRAVRALTESGHEVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1C7</accession>
    <name>A0A7W7T1C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23016" checksum="28C23BFF7855C098" modified="2021-06-02" version="1">MSRPITVLLVDDHPVVRDGLHGMFAASPEFEVLGEASGGEEAVAMAERLDPDVVLMDLRMPRGDGVAAIGELTRRGLRCRVLVLTTYDTDADVIPAIKAGATGYLLKAALRDELFEAVRAAALDRTVFSPSIATRLFTEVRTPAPRERPLSARELDVLTLVAKGTTNREIARTLFISEATVKTHLTHLYAKLDATDRAAAVAAAYDRGILKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q2</accession>
    <name>A0A7W7T1Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RecB family exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32470" checksum="131904068BAC0140" modified="2021-06-02" version="1">MALPIIERPVRRPALSPSRAGDFKQCPLLYRFRAVDRLPEKPTRAQVRGTVVHAVLEDLFALPKDERVPETARALVKPAWDRVRVERPEFAGLFVDAEDGEEGAWLASAEGLLDGYFGLEDPRRFDPDARELLVEWEMPSGVLLRGYVDRVDVAPTGEIRVVDYKTGAAPREVNEAKALFQMKFYALVLWRLRGVVPRQLRLMYLADRQDLVYAPDEGELARFERTLEAIWDAILRAAKTGDFRPNPGRLCGYCDHKALCPAFDGTPPPYPGWPEPDDAESVLDRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R2</accession>
    <name>A0A7W7T1R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31437" checksum="347638D9D2D3C494" modified="2021-06-02" version="1">MDELDGVSATLATRRLGLTLRALRGRITTLRVADVAKAAGLSQPTWSQVETGVAIPSSEHLAAAAKILEATDEEVATLLALRERAKRREWWHEYNDITSPNLSKLIGYETSAIDTKMCAGGWVPGLLQTPDWARAAINVAGAKTRPEDVERAVELRMRRQAVLDNPRARLHAICGEESIRYRAGGWDVQTTQLRHLLEVGEAENITVQILPFTAGLHIGHSQPYSIFEFGEFDPPIVHQEDLVEVTLTDNPAEVRRCKYAFGVLEGLALSVENSRKLIESILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R3</accession>
    <name>A0A7W7T1R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="29"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="26368" checksum="667DBB42592A572C" modified="2021-06-02" version="1">MNFAPGTFTPAPGRGRLGRMLLVQARTEAVLTLRNGEQALLTVIIPIGLLVALALMSVIPMPEPRVGSAAARVFALAVISSAFTGQAIGLGFDRRYGVLKRLAATALPRWLLISGRMAAAFVVVAVQVVVLTVTALLLGWQPSLAGVAWGLLVIVLGTLTFGALGVLLGGALRAEIVLALANIVWFLLLLVGGVALGVESMPGWAATIVHLLPSAALAEGLHTALVDGTAPAPRDVLVLSGWGAAAGALSLRTTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T215</accession>
    <name>A0A7W7T215_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">F4559_001259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="18021" checksum="7F3A55788B67E598" modified="2021-06-02" version="1">MTRAVCPGSYDPATNGHLDIIGRAAKLFDEVVVAVLINKNKRTLFSVEERTEMLREVTAQWPNVRVDSWHGLLVDYCRENDIKAIVKGLRAVSDYDYELQMAQMNHQLSGVDTLFMPTNPLYSFLASSLVKDVATYGGDVSSLLPPSILHRLNLRLAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C9</accession>
    <name>A0A7W7T2C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="257"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="529" mass="56843" checksum="4BA4F170F98043F2" modified="2021-06-02" version="1">MTTVRAGRPDEAEALSALILRSKAHWGYDRAHLDACREVLRLRADEVTARRTLVAERGGTVVGVATVDGEPPHGTIGLLFVEPDAIGSGVGRLLYRHVLDEAARVGFDEVTIESDPHAVGFYAAMGAWQDGRRLVAYPEPAWSTAWNAGAPMVRVGNVAEFNGQFGARSRGPDHYSCLVAFCGRRPAAIVLPQPVDEWWVRHVETVLGWENLRVSTALSEAPAGRPVPWGLTAAFASTQVLATVRRYESKRNAHELFRALARPGIVVPAQRPMGSRRALARELAAGGRVVLKREYGVGGSGTLVVSAGTGGLRRWAGSLVEEYVDAVDNPTFDAVVDADGRVHPVGVGVMEVVGTGYRGVTVGPGLLPDHLVAAATAFGLDVGRVLAAEGYRGWYDVDFVTARDGRLAPVEINIRLTGPAAAFNLRDVLDRRPLVRTVDWMPLGARLPPAALRDHVARFPGNVVVTIPTAAFDPAPYLGVAISGRTRRELDDTEAAVRAANADLGAMFADLTPASRRGPRWRRRSSGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J8</accession>
    <name>A0A7W7T2J8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24253" checksum="158EF3C0B083057C" modified="2021-06-02" version="1">MLFHPTGATHPLVETADFRGPLPDGVAAYGPALRAVFDWAGEYLVGPHPELGRRGAVCPFTDTSLQRGLFWISVHPGVPHGPDELAELLLHYRDWFVDLAPTAGPAAQFKTILVLFPDLADHTVVDRTQELLKPDYTQQGLMIGEFHPGPPDKAGLWNPAFRPLRSPVPLLAVRHMVPTDFPFLRDDDATVAAYLQRFGDRVPGHLRGDVSAAADRLATSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K3</accession>
    <name>A0A7W7T2K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="30347" checksum="47DC5B3CA74BA2EC" modified="2021-06-02" version="1">MIQRTESDRTPAAQGSPEGEARRTGVAGLRRVTPSPTRAARQDLPMRTLPVVGTAMAGELVPPAASPDRPTVRRPSSAPVLGEALSRVPDTAATPGRESARRTTPSREPDRGRPPTEQPSLVVPLTRSEARLPGGESGPLVPLLGDRPLTPLLRVEGGPPTRRPVVRPRWTPAPDVGVQRTTPRHAPPPRGPLTMPVAGSTQRTATPTSEALPDKGIPKAHPTVTTSKTTTSPKPADLAKPAKDEHEQIDPDRLARRLIEPVARLLRAELRSGRERSGRLHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L8</accession>
    <name>A0A7W7T2L8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13694" checksum="95E61CE301CFF38D" modified="2021-06-02" version="1">MDARGFARDWERWWNDRDLEPLLARYADDVVVRSPAAARLLGDGVLPDGVLPDGVLHGRRAVREFWARGLAAVPHLRFAVVGVFEGVGTVVLHHRDQDGRFGVDVFTFRDGYVVEVVGAAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R3</accession>
    <name>A0A7W7T2R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator DesR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21329" checksum="7AA8652A8C5B24C9" modified="2021-06-02" version="1">MIRVLLADDEEMIRDALAALLELEPDLEVVARVGDGRLAVDEARAHRPDVAVVDLRMPGLDGLEVTAELARVLPSCAVVVLTGQGRPPHLRQALSAGAKGFLPKGSPGGTLADVIRRVHSGARYVDPALAADALTAPPCPLTRRELEVLRLTEFDTPVGAIARRTGLSAGTVRNHLAAVVTKLAVPTRAEAFRVAHDNGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T330</accession>
    <name>A0A7W7T330_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="63"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="440" mass="48000" checksum="E2EB8B8DB62414D6" modified="2021-06-02" version="1">MAIPVAAQAESPRDDIDWTASGCPTGLDCGTLELPVDWARPHGETFRLALARRPAVPGARRIGVLVVVPGGPGDSGVDHVSRFRDPALDGFDIVGFDARGIKRSSPVVCSADVLARRPATPVDQPGFDRLVAYNRELHDDCVRHTGPIADHVDTGSVVRDLEAVRRALGEPKISLFGHSYGTLLGLAYAERHGDRLRALALTGLFDHSQDTGGFLRTSAVAVEDAFHQFVRWCDTTPSCALHGRDVVAAWDDLLARADRGEVPGQTAESLSIAAHRSFYGPDHQTLANLIAGAPARSATTTPYPFQAIFCDDFRVKIRDYAEFSRYADQQRRLAPHMRGALRQFGAVTSCIGWSDRVSFPQHLLTPHRGTPPILLMNSRHDPAGLYSWAREVERQARGRATLVTYEGPGHNVYPKTSCTTTTMHRYLVDLTVPTTTSCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T342</accession>
    <name>A0A7W7T342_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8498" checksum="3E259CD246670F99" modified="2021-06-02" version="1">MRSRPTPPSAVHDHLDYLDKLATDGDLRSRAAPAGTEITRLTSAWRSLLDATDSTSTVAAGGARAGFASASAPAPSGPPHTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C3</accession>
    <name>A0A7W7T3C3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="22"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26517" checksum="4BAFAE59D9C7D8A4" modified="2021-06-02" version="1">MTIFLASVRLQLERLRRSPGSLQALVATPLYSLVFLSIVDLAGRPDLMAYAVLAPGVMALWSIGLTVSGETVDEERANGSLELLVAAPVSLTVVVLGRVGTITALSLVSVAESWLVCWAVTGVLLPVADPALFAGVLLCTVAAMVGTATALAGLFVLARSARVLQNALSYPVFLLGGAMVPTALLPDWLRPVSRLVFLSWSTDLLRQSLGGPRVVATGTGIAMILLLGGGGFAVGVVLMRRVLTRVRATGAVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M1</accession>
    <name>A0A7W7T3M1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltose O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.79" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008925">
        <property type="term" value="F:maltose O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19123" checksum="6FD01EEFC419FB24" modified="2021-06-02" version="1">MERMTRGDWYLDGPDLVGARDRCRRLLDRFNATADDDARRPLMAGLFAHVGPGAVVLPRFRCSYGTQITLGAHCFVNTDALFMDDAAITIGDHARLGPDVRLVTALHPVEDHDRRKAGWERAAPVTIGANAWLGVGVIVCPGVTVGADTVVGAGSVVIRDLPDRVFAAGNPARVIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M6</accession>
    <name>A0A7W7T3M6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="194"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="31887" checksum="D70FBB39135094BF" modified="2021-06-02" version="1">MDAVSDLLTDVRARGAVFQRTIMRAPWALRIVGGAPLTLAMMLRGHAWIVPDTAPPVRVGTGEIAVVRGDVPYTVADSPTTAPTRVVTDDDYCTPAFGPLDDDAPVLLSGAFERRGELSEHLLHALPAVLTVPAVAHPPAAVVADEIAADRPGRQLVLDRMLDLMLVAALRHWFAAPHTDAPAWCRALDDPIVGTALRLLHDTPDQPWTVAGLAAKAGVSRAALARRFTTLVGEPPMAYLANWRVALAADLLDRTDHTVATIARKVGYANAFALSVAFKRLRGTRPSDHRRALADRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T412</accession>
    <name>A0A7W7T412_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="356"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="785" mass="84805" checksum="8C5E4CB4FCB7CF38" modified="2021-06-02" version="1">MTPRPERGEMVPMVFDGAMVDDETVAAQGQGVPRLAFPRWRAVVGVAGDRVRAAVRCPAVVHARSVARYRVRQAPRDAVRLSWFLVRGVGRWGAKGWRWASHADLRADARAARLAGDVQARRTAQETIRADARVRWARAGGVVRRVAVGAAVATVVLVLLALGEMVAGREVMPGWLRAVYAVRDAIGHGVAVGWPWVWRSTVCALVCAAVWEGRDRTPGASWITRPDRDDDGSWVDERMISKALAHLGIAPLNAFLRGGGELVYTVPARRDGDGTHARIRLPLGVTADMVCDRRRVLAGNLGRASLETWPTTGEEDGVLDLWVADKGTLSGGAGGWPLLHEGTVDVFDGVPVGLSQRGVVVAPPLPESNWLIGGRPGQGKTNLLRVLLLGAALDPTCELWVFVMGESPDFEPLRPRLSRYRMGLDDTVAADAVRALEDLCAEMERRGRILGEQPGRPPKVSRRLADKPALGLHPLIMSIDECHELFQHPRYGKSAEEFAVRLIKRGRKYGIVLLLATQSPTKDSIPREVTRNVSCGAAFAVADHIANDGLLGSGRYRAGIRATELRMRTDRGTCVAVGVTDATFELVRTFYVPFEDGADLVTPVVVRALEHMASTSRTMTAREPIPEIMAAPVDHLEDIHSVIGDEPRVRTQVVLARLAAHNPGEYEPWSARDLRAALLRHGVHSYKSDGAMVVRVADVVSALARRPQAIGVDEDAADVPADDREAGGTQGVIPASSGRLSPSRSLRKGPSQGGPSQTDDEPANGPHRHLDGRSADSLPPDVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T484</accession>
    <name>A0A7W7T484_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="39936" checksum="DB7685ABB9EC4DE5" modified="2021-06-02" version="1">MMCVESRTLREIGRCLATGRPHHALDHAFHLLGTEPHAPGRRFLLIAELAGRAGRPLGAAYYRDLARRTLPDGHPPIEIPDLPRHPDDARKSAMPPERAHYAMGRAEQALRWLDHRVTTSPFAHDWARTALLRETRASAHLDGVHLALIEVFHHVLSTSPVGQWREPAFARYLSATLGLFDTPTAPLVAEPLADVLTRHVRTPPATGHALRLALPVALVRARWLTRPWLPLSTHHRGTDPPRPRRADVLAAVGRIADALTRTCHAEIAVLDVLTRLHDHPAATRTRNLRAVWTDLLTRGAVTATDLATRHGFTTKTGYNTATALRTLGLARIDPRPYGRTIHNPDALHLLATSHHPENHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T495</accession>
    <name>A0A7W7T495_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17039" checksum="B62E0CEDE00E31AA" modified="2021-06-02" version="1">MTSPYEHLFVRKMQSCLDDLVNEGGEAGLPDPDNVGAALALMRSKDVPESKVHLTYTWINECSEPVQWVKEHVHDYDEVLIWHGNDPNDVDDLGAEIYLDIEGVRHTITTSGSVYLPAGTRHCPLGFTRVDRPFRFSALSLSPNYGSATGPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C1</accession>
    <name>A0A7W7T4C1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7806" checksum="FED0A262AAB597C8" modified="2021-06-02" version="1">MVDSPEFLVVLNDEEQYSVWFADRDLPLGWRAEGTRGTREECLEHIGRVWTDARPRSVREHLRAHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K6</accession>
    <name>A0A7W7T4K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="415" mass="43877" checksum="E9E08892399FDCA9" modified="2021-06-02" version="1">MTPLLIALRRGSAPVAVPVMALLGLFAGTREDTIVDWGWASGQLQQHGVLLVPLTAALAAWDVSRDRRSGSPALTRTYPRPSVRWVLLNCVGAFLAGLVGWAVTLGMVATNVRGTGGPYWSVVLLGPFTFVAAVLCGAVAGRYLPRHLAAPLTAVAVWLGLAFGSTSADPVLARLSGVDRECCDVASQPVAATVAGQWLWLAALAVAALAVLLTPRQAGVAGVAALAMAAVAVVTIRGTDARLTEPRTATAESCGTRAEVTVCLWPEHAADVDAWLAAATRYRSLFADLGDQPRLYLEYGLRPAQDVPRLGPVRPGMSEDDLVTALARRLFPTPPACAEIEGGSKPYPAADADALLSGWLARRIRPGAPADRFVPPDQVALLDRLTGSRPEDQRRWYADLVRAHRDCTTPAPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P1</accession>
    <name>A0A7W7T4P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diadenosine tetraphosphate (Ap4A) HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="23"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25962" checksum="DAD60FB9E0464C80" modified="2021-06-02" version="1">MTSAVQCAGADFCEEISGAADTAFARFYEGDPPSRRVYSTPDFELLVDMSPLTVGHLLLLPRAHHLSFARVLAAHPDETELLVERITALYAETSREPLVPEHGSGVDQESHACMTHARLHFLPVDGGVVDAMLAGDGLRYRDLPSLGALARPPWLESAYFLRLFDGRCRVYVPSAAQKRQYLRSLAGAALSIRDPEWDYAVVVRKDDLRTTMRRVADWPDRLARAGGWGRSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z2</accession>
    <name>A0A7W7T4Z2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="25524" checksum="294DDAD4455FE55F" modified="2021-06-02" version="1">MKTIIKTEWTLFLREPATVVFAVLFPSLLLVVLGAIPALRQPQPDFGNLRFIDSYAGSLVVITMAFLGLNRLPATVAGYRENGVLRRMSTTPVHPGRLLVAQLAVNLIAGAAAFALVLATGRLVFGIELPRHPVSFVLVLLVGLLTLSALGLLIAAWAPNARVAGGLATVLFLVVMFFGGVYLPRFMLPEVLVVIGDHLPPAVGAIQSAWLGTGPSLVQTGITAVIGVLAGTVAARSFRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z5</accession>
    <name>A0A7W7T4Z5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="484" mass="53316" checksum="DE91D96D3F9648D7" modified="2021-06-02" version="1">MKVFVNYRQRDADGRLLPHALAAEALAERLAGLLGTGTVYFDTTLPPGRRYSDMLRRRITEAMVVVVVVHENWLADLRAREGTRKDWVRYEIAEALAAGKEVVPVLIGDAELPGHRDLPDDIRGLADAQAVPLRLGRFDQGVQALAAEIGLRVAPDEEEPLTVEQVPDRGRLAVAVAGAIVLVLFGVVAPAADLLSERFHVAGVGPYLAVFAVIPGLPLFVVFGIAGTEFALRRPMQWLNDAIERNTEEKSYVVFGLGLMFSGFLLLLLVVVSAGGLSAPTVGLVIVVWIGTLLVTAIGWVRKQDSRRHWPYFTGRPTGFWVQSELIHLRRHLDRGRDGWTRPLPLARRRTAELVLDRVEEVVAIMAADAERGRVRWWRTRNPYLNALHVGGVACAVAILTIALIVHAATAGIGAADLLWWAAGVATALLFYVGGVEFAFRTYRWRIAETQRTLPDRLAQVRARLAEMSTSIPYSAYLARTEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q3</accession>
    <name>A0A7W7T5Q3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030978369" evidence="2">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="42117" checksum="E68261E5928736EE" modified="2021-06-02" version="1">MKRILMTATALCVAVGLAAGTASATSSQHRTLQKDADALVALGAPGVLVELDTPRGDVRVRSGYGDTARKTPVPWDARFRIGSFTKTYVATTVLLLAGEGRLSLDDTVERWLPGLVSGNGNDGRKITVRQLLQHTSGLHNYTRDLDWLSSREGFERNRFRSYTAEQVVREAVKTAPDFAPGTNWLYSNTGYALAGMIIEKATGRTWQQEVTARVLRPLRLNDTYSPGDSPFIAGPHAQGYQRFPDGGTPEKPTFGPQIDVTVTKVSWGGAAGDMIGTTDDGNRFLQALLGGKILKPAQLAEMKKTVPATVYQGWIPGLRYGLGLMWNPTSCGGSWSHGGDIPGFMTRNGVTDDGSRSVVVTLNTDSPIPADGTLPTKEISLGIVEHALCGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5W8</accession>
    <name>A0A7W7T5W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28450" checksum="5798527AD51D8ABE" modified="2021-06-02" version="1">MVRGLVVLGDSTTFGVGDPVPGGGWRGVGALLAAAYPGARYTNPSFPGARVADVRRTQLPKALATGPDAAVILVGMNDTLRSDFDAARLHEDFDAIVTGLRAAGARVVTVRFHDHSRVFRLPTVLRAALKARIAELNEVIDAVVTRHGIGCVDLDRLVGAYDLDTWAVDRLHPSEVGHRRLAAAFADRLADAGLPAREPVSLEPTGGLRITPLHHAAWLVFKGVPWLWRRGRDLVPYAATVYYRAWTGRGQAVAEGDRLSVETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y9</accession>
    <name>A0A7W7T5Y9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTP pyrophosphokinase</fullName>
            <ecNumber evidence="8">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="86"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="427"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="690"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="766" mass="85083" checksum="B0D72D74FFAF9669" modified="2021-06-02" version="1">MSQDTDPASTAQPVPARPPSATRRVRARLARRITAQRAAPVKQVLEPLAAVHRDLHPKADLALLQHAYDVAEEKHRPQRRKSGDPYITHPLAVATILAELGMDTTTLVAALLHDTVEDTDYSLDQLKADFGNEVALLVDGVTKLDKVKLGAAAEAETIRKMVIAMAKDPRVLVIKLADRLHNMRTMRFLPPEKQARKARETLEVLAPLAHRLGMATVKWELEDLAFAILQPKKYDEIVRLVANRAPSRDTYLSGVINELSQQLEGARITAKVEGRPKHYYSIHQKMIVRGRDFDDIHDLVGVRIQVDEVRDCYAAMGVVHALWQPMPGRFKDYIAQPRFGVYQSLHTTVIGPDGKPLEVQIRTYDMHRTAEYGIAAHWRYKETRGTHSGKAVEVDEMAWMRQLLDWQREAADPGEFLESLRFDLAAREIFVFTPKGDVVTLPTGSTPVDFAYAVHTEVGHRCIGARVNGRLVALERKLENGEVVEIFTSKAEGAGPSRDWLSFAASPRAKAKIKQWFAKERKEEAIEVGKDAITKEVRRVGLPLQRLVSVDSMGALAKELHYPDVSALYAAVGEGHTSARHVVQRLVAQLGGVEHAEDELAERSTPSTVTRRRVTGDAGVIVRDATDVWVKLARCCTPVPGDDILGFVTRGGGVSVHRTDCTNADELLRTPERLLDVEWAPSASSVFLVAIQVEALDRHRLLSDVTKVLADERVNILSASVTTSRDRVAVSRFSFEMGDPKHLGHVLKAVRSVEGVYDVYRVTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T619</accession>
    <name>A0A7W7T619_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030825282" description="GH18 domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="40"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="582" mass="59471" checksum="E2E255A0E674B437" modified="2021-06-02" version="1">MRPSRILIGLTAALAAVAVGSAPAPAAPAKAAAATPLPAHVFAPYFEAWTGDNPLTLSKASGAKYLTFAFLQTQSPGSCTPLWNGDPNMPISSSVFGSEIKAMQAAGGDAIPSFGGYTADTTGTELADSCSDVNKIAEAYQKLITTYDISRIDLDIEIDALDNTAGVDRRNKAVKLTQDWAAANGRKVEFSYTLPTTTRGLAANGVALLRNAAQNNTRVDVVNIMTFDYYDNATHNMAEDTKTAAQGLVNQMAQVWPGKTQAQLWASVGVTEMIGVDDFGPAETFTLANAPVVLDWAREKNINTLSFWALQRDNGNCPGGSAADNCSGIAQKQWEFTGIFAPFSGGGTPQPDNDFSVGVTPSSVALDPGKTASATVNTAVVKGTAQNVALTASVSGGSGVTASVAPGSVTAGGTATVTVNAAATATPGAYTVTVTGTAGTTTHTATLSVTVNGGQPGGPLANGDFESGVLAPWTAPGDSIVSTPAHSGTHALQVTPSASSTGQASQVVTLAPNKQYTLKAWVRGNYVYIGVSGGATGSAWTSSADWKQLSVTFTTGASGTATVYAHGWYGQSPVFVDDVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T634</accession>
    <name>A0A7W7T634_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6897" checksum="4CFA5BA8D951987B" modified="2021-06-02" version="1">MSTRTEHARDLVDVRTGDLFDQPDPYGLVYAVRLADGEAAPSQRGRTWEHLTASGRELRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D8</accession>
    <name>A0A7W7T6D8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="90"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34380" checksum="3713517BB0AF077A" modified="2021-06-02" version="1">MTHTPVPFDPEIEAALAQIVQPDAPPFTPESIPAMRAGMAAMFPPAAEQVGDAPVDVVERTIPGPEGAPDLEITIISPRGLTGPVPGLYNIHGGGMMVGHRNMDVGRLLALVLELNVVAVNVEYRLAPEHPDPAPVEDCYAGLVWTAANAAELNIDPTRIVVMGGSAGGGLSAGVALLARDRQGPALAGQLLLCPMIDDTNTTIASKQYSGIGTWTRESNIAGWNSLLGDKVGTDEVSPYAAPTRAKDLSNLPPALIEVGSAEPFRDEDTEYATRIWATGGNAELHVWSGAFHGFDMYVPDWNVTKIALEVRTNWLRRVLGLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6E2</accession>
    <name>A0A7W7T6E2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="6"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="41056" checksum="7BDDD218C5A93629" modified="2021-06-02" version="1">MSLRRVAVVLGLLEMFGPISMDLYMPTLPQLAGDLGTSDSLAQATMSACMLGLALGQLVLGPLSDRYGRRKPLLVGVGLFAVLSLVCAITPSIELLLAARFFQGLCGSAGIVIAIAVARDLADGVELVRLLAMLGTVGAIAPIVAPVIGGQLAPFMGWRGIFAVLAGIGVLLFVLALTSLPESLPPEARQVHGSTGEFAVVLKDKLFLCFLLVGAFGGVAFFTYLASISFVLQGSFSMSPQLFSVCFAANAIMSVVGAQINRLVVRRLGPARMYTIGTTMGAVAALAMLVSVLFDAGLVALLVPLALLMVASGGSYGNGTALALEDHRDRAGTAAALLGTAGFAVGPLVAPLVSLGGTSPLSMSLTMTVAYALAAVLVWTLVLPRLRRRQAASPEPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z1</accession>
    <name>A0A7W7T6Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15546" checksum="4A5672422748205E" modified="2021-06-02" version="1">MNSRRDSTDGPEDVDAAFAEIVASLEREGVGTSWPDEKPEPPEEVDRHVDRPAPVDVADEEDDPADHYVPPEPPPLPMLRKGTIAALALILLGVVLLVFPGLFGLSSRIGTPLALVVLCSGVGWLLLRLRNNPPPDSGWDDGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T716</accession>
    <name>A0A7W7T716_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="36027" checksum="DAA15C4DD648FF10" modified="2021-06-02" version="1">MEFRRLGRSGLNISEISYGNWLTHGSQVEEDQATACVRAALDAGITTFDTADVYANTKAEEVLGRALKGERRESVEIFTKVFWPTGPGGPNDKGLGRKHIVESVNGSLKRLQTDYVDLYQAHRFDRSVPLEETFLAFSDLVRQGKVLYIGVSEWNAEQIARGAALARELNVPFISNQPQYSALWRIIEAQVVPTSEREGISQIVWSPIAQGVLTGKYLPGQPVPAGSRATDENGKNFIARFLKDDVLEKVQRLKPLAADAGLTLAQLAVAWVLQNPNVASAIIGASRPEQVHENVKAAGVKLDEELLKRIDEVLGDSVETDPRLTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7F4</accession>
    <name>A0A7W7T7F4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6265" checksum="7685B6F30CC697B5" modified="2021-06-02" version="1">MTNWRKSSHSGDGGTGGGDCVELAVDGNRFLVRDSKNPDAGTVTVTRSWLDALKSDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7R6</accession>
    <name>A0A7W7T7R6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="41"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33956" checksum="901C3375E5DE83AD" modified="2021-06-02" version="1">MTTLAGHREHTAPIDLLNALRTARAAGGDALAATLDEHGLHALDGGRNNDVFAWTAAPSPTCIKLFLKSDRQRVEREWHGLAHAAGLGIAPEPLWLDEDLEQPALGMTLLPGSPILDVLDPASAIKSLAKTTRALQSVPLKEPLANLERVDSIGRYIARLTDVWPGQLADAADDPQTPEMLALLHRWENSGDAELLAQPVPHVYSRGDANLLNWLQNGESTYVADFEFSGFSDVAVDAADHIEHISARVVPDNIWTSAEADLGVTPGNRARFEAARRTIALRWLAVLWKQRTKRVEEFTALHERVRVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7S2</accession>
    <name>A0A7W7T7S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein-anchoring transpeptidase ErfK/SrfK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030577441" evidence="5">
        <location>
            <begin position="31"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="64"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="256"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="42098" checksum="8F3B2FF30D1A10AF" modified="2021-06-02" version="1">MSGRRGMRGAWGAVALGLVTALVTACSSGAADNAGSEPTVAGETAASPESKPVSLSVGPADAAVDVQPGIPVVATATDGKITQVTLTNADGKAVAGAVGPDGLQWTNTEPLGYGKAYTLAVTGQGTDGKQITRTSSFTTVTPRTQTFLSMNPMDGTTVGIGQPLAFYFDEPITDRAAAEAMISISTEPKVDGAFYWFDEKEVHWRPQNFWAAGTKITVDAKVYGKHLGNGVYGQEDRHVTTTIGDAVVHEADGQTHQVTTKINGQVARTMPTSMGNAANTTPTGTYVLMEKHDHMVMDSRTYGLALDAGGYVTPVDWATRMSNSGIFFHSAPWSIGDQGNRNVSHGCLNLSPENAKWVFDLSKPGDVVIVTNSGGPALEAWDGFGDWQIPWDVWSKGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V2</accession>
    <name>A0A7W7T7V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="416" mass="44080" checksum="4559EBC38EA08821" modified="2021-06-02" version="1">MTTARTGPDIARISGYFLLNLVSGIFWFSLLTSLLATSMGLLVVWIGFPLLALTLMLARTAAGVERAWLRPTLGIAIESPYRPIPEGSVIVRTRAMMTDPATWRDLLYWVVMLPLGIIEFALVVALWPAVLSLVTFPVYQQWLPGNLEITLGADVYTIDSFGEAVPVSVVGIVLGILLLPLLRGLARGHAALAKSLLGPSRNEKLVAETERLSASRARGVEAAEAERRRIERDLHDGAQQRLVAVAMGLGRARGKMESDPDAAAALIAEAHADAKLAISELRDLARGIYPSVLGDRGLDAALSSLAAKCPIPVTVSVEVDPRPPTAVESTAYFTVAESLTNIAKHSGATQADVKVTRTENSVVVEVTDNGHGGAEVRQGGGLAGLADRAATIDGVVVVVSPVGGPTVIRTELPCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X8</accession>
    <name>A0A7W7T7X8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8578" checksum="7F7DAAD197E2F358" modified="2021-06-02" version="1">MAMLVYLHKEAETEAEARYRFHTDGGSDRYLVLDKRSETITPDDGDRDGVFRAAAGKLARAWLDTKAAPDRLIHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T852</accession>
    <name>A0A7W7T852_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21380" checksum="7B10BCED07CA8F0D" modified="2021-06-02" version="1">MADRTKIKNPLALALLGLLLERPMHPYEMATTLRERYKDRTFKVNTGSLYDTVARLAEHGWIAASATERTGNRPERTVYGLTDLGRAEFTDWLDALLRNPVKEFPQFLAAVSYLGALEPERAREALEARAGQLEKTATQIRATLEEVLAGGLPRLFMIEVECALRLLDAELAWVRETAAEIAAGTLAWPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T876</accession>
    <name>A0A7W7T876_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar biosynthetic protein FlhB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="38613" checksum="D6C0C6995D4DED45" modified="2021-06-02" version="1">MSKNEGTEKPTEKRIRDARKDGQSPRTAEIGNWAAVLAASWLAPMGLSSLMDSAQLMMRGTADFIAKPDTGVALRMLGDGLGKGAWAVTPLLAGTVVATLVAAAAQGSLRPSPKLLIPKFNRLNPLPGFKRMFGPQAAWETAKTLMKTAVLAIVLYMGLKDLVPTALSAGTLPLSALVGLVGDTILTLIRWAGVAGLVLGVVDYFVSRRRVMKELKMTHQQIREEHRNSDGDPQLKAAIRQKQMAMGRNRMMADVPEADVVLVNPTHVAVALRYDPAKGAPRVVAKGADAIAARIRDLATEHRVPIVRDVPLARALHKACEVGQEIPADLFEPVAHVLAFLYRLKRKGSAAGIHTMTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T881</accession>
    <name>A0A7W7T881_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein FlbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9545" checksum="CD6AE716DC8135AD" modified="2021-06-02" version="1">MILLNRLNGQVFALNPDLLERADPTPDTVITLVTGAKYVVAQSLDELAELVSNHRAALLERAQLGTDNPGPSRAARATVLRFPEGDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C3</accession>
    <name>A0A7W7T8C3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="36592" checksum="C1593C21E25F8E99" modified="2021-06-02" version="1">MFRYIIRRLLISIPLLIVASFLCFALTAAMGDPLGEWKLQKPRTPAEIAQAYERTGYNKPFLERYGDWAVNFAKGDWGKSIAPGHAGKPVKEDVLRAFGVTLRLILIAEFVALALGMAVGVIGAVRQYSLFDYVATGISFTMFSMPLFCVALIIKQGGISLNDWLESIGADRWITTAGPPGDGFKGSFGEQVYQYTGAYLLPTICLVVIQFALYSRFQRASMLDTLNSDYVRTAQAKGISQGRAIFKHAFRNALIPIVTVSSLNIGLQFSGAVITETVFGWSGMGKFIIDAINGLELYQVLGFMMVTAVFIIAFNLIADILYAFLDPRIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N5</accession>
    <name>A0A7W7T8N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27783" checksum="80342F4A786000BE" modified="2021-06-02" version="1">MGEGRGDGRSKGRGTGRAGSSRARSGRAGDSDKTSRDKAARDKAARGGPAGGDRISGGKTGRGVTGGTTKTPAGGTGRGGRDKAPEGKSRGVLGTGKSSGTKPSGAKSARDKAKARRESARAANRRPQSRARTRAGAGTGGAFGMTGTRRAALLAMVVCALALSIAVPLRTYLAQREELREATAEQDALRAEVDRLADRKEQLADPARREIEARQRLHYVRPGETPYVVQLPGDENRTPEDRKPAAGPAKDKAWYEQLWNSVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T934</accession>
    <name>A0A7W7T934_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="45" mass="4854" checksum="B90BB57108A9DC20" modified="2021-06-02" version="1">MPVMSMANGLSLNLDRPAWVAAFAEPQLLTGQARVHHPRSPARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G3</accession>
    <name>A0A7W7T9G3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="31317" checksum="8E6AEEBE922AB1AF" modified="2021-06-02" version="1">MTDDLERVTAIRDPRERALTVGKLIDEYQNLINELSRVRRDTLDELLATGISQKQIADLLGMSKGRVSQLLTAGLKPERAFYGTGPVTVAIGAKREENRADPSDILSVESFGAFELLSESARKVGLSATHEVVPRPGNVHLNRPNLVVLTNPRLLPFLAQVMEADPHIRYVEDGDGWFLFDNSTSTEYRSPRDRGDSADYGYVGRLPRPDGKGTFLYLAGTHAPGTYGAARYLVDNLATLYKELKARRFSFVVRYSYEEGNRLRMRSVERVTPIYRHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H2</accession>
    <name>A0A7W7T9H2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="20818" checksum="DFBA52DA5B4576C8" modified="2021-06-02" version="1">MSVPVTPSATTEDSAESRKLRVDVALAEYNALKAEQSKRIGHRDRTVYSTLAAGAGVVAAAASSGHAVLLLALPVVSLLLGWVYHVNDELIGAAGRYLREHTGPRLAALLGDVPALGWETAHRSDARRRLRKIGQMVMDLTAFVVMPTAALITWWTTGPCPAGLVVVSIVETLLLGWLAVMTVLAADLTTSAQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N1</accession>
    <name>A0A7W7T9N1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="10948" checksum="142578DEE27FFD23" modified="2021-06-02" version="1">MSARVVSAVVGGAFVLAGLLILLLPIEARSPGGIAVACGNAWGAGFDDVALEAQGVALPEVCARLRERRYGWGLPVVVFGLAVGAGTFFVNGRVARRGKPAGDAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R1</accession>
    <name>A0A7W7T9R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21231" checksum="D5B1A98A1D9BA755" modified="2021-06-02" version="1">MLRDAGRSVDLITGDVRPAVPAFGQLVPREPVTVASAGSGPRWRVASRKIGDGELVVGVGQADVDDAVGDLRRTFLLISACALVLMAVTGYVLVRRSTRPLEEVEAIAAGDLSQRVPVRVPGSEVGNLATALNTMLGQIESAFEARATSERQARGSEVRMRRFVADASHELRTPLTSIRGYAELFRQGATPAVRKLAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9S6</accession>
    <name>A0A7W7T9S6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019595">
        <property type="entry name" value="DUF2470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10615">
        <property type="entry name" value="DUF2470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2470" evidence="1">
        <location>
            <begin position="165"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="27569" checksum="7F2160616E8A06EA" modified="2021-06-02" version="1">MSEDRRPPAPHPAERARTIATRGGRAALLPSNGTEARITPAFHHVHPTGEATMLLPDDHPLVRTGATTGMLEVADHAPVTLREPVRGLLWITGWLRVLDPQEARQACLEVAEQRPDPRLLDVGHGMSALRLEPASIVVADAEGTTSLQPDLFATAEPDPFCTHEDHWLRHLELSHRDVVGLLSQHLPEHLRGGHVRPLGLDRLGLRLRVEATDEDHDVRIAFSRPVATAQELSVELRRLMGCPFLAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z3</accession>
    <name>A0A7W7T9Z3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ORF">F4559_006637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="434"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4969278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="656" mass="72937" checksum="2DB62405ACA3CD85" modified="2021-06-02" version="1">MAAQNEYSASSITVLEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNSVDEAMAGFATKVDVTLLANGGIRVIDDGRGIPVEMHPVEQRPTLEVVLTKLHAGGKFDSDSYAVSGGLHGVGISVVNALSTAVDVEVKRDGFTWNQRFQAAKPHGELVQGEATEETGTTITYWADPEIFETTDYNIETISRRLQEMAFLNKGLTIVLRDERVQEAEDEEADAEGHVARVRERVFHYPGGLADFVRHINHSRDAVHEKVVAFEAKGEDLEVEVAMQWNTGYTPSVHTFANTINTHEGGTHEEGFRAALTRVVNEYARDKKLLKEKDSNLTGDDIREGLAAIISVKLKEPQFEGQTKTKLGNSEAKSFVQKATNEHLADWFERHPNETKVIVTKAVSSAQARIAARKARELVRRKGALEIGGLPGKLKDCRSTNPEECELYIVEGDSAGGSAKEGRDSMFQAILPIRGKIINVEKARIDRVLKNNEVQSIITALGTGIHEDFDLTKLRYHKIVLMADADVDGQHIRTLLLTLLFRFMHSLVEAGHVYLANPPLYKIKWQRIEPEYAYSDRERDGLIESGLAAGKKIGKDDNIQRYKGLGEMNAEELWETTMDPANRVLRQVTMDDAAAADELFSVLMGEDVEARRSFITRNAKGVRFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA95</accession>
    <name>A0A7W7TA95_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor ChrR (Cupin superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="15097" checksum="055ECE5F31C51BA1" modified="2021-06-02" version="1">MRDVKVYHSLFGEGLRNGQIKWAEYVQPGRNAVDVEWLYTQDETGPTGAEAYIAHFKPGSHGDLHEHLGYEVLLILEGELHNDNGDRYPAGTLFVEKPESVHQVSSPSGCFALVIREKGTRRIEVPEPAGRAAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA97</accession>
    <name>A0A7W7TA97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7060" checksum="EEC7122DBFE31C5E" modified="2021-06-02" version="1">MIYVSGVASSNYIRVGGDVAMKCSVNADELEVSLGAGQVDFVLSRGATERLHVEMGRALELMRADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC0</accession>
    <name>A0A7W7TAC0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_006326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030651895" description="Peptidoglycan glycosyltransferase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="711"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="773"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="819" mass="87715" checksum="E90193FFA0F49B56" modified="2021-06-02" version="1">MRVRNSVLKLLGLCLLAGVLLAGMLFPVMASLGFASNRAGDTVDAISADLVATDPPLVTTITDRDGTPIAYLYDQYRVLVPPEKISPTMKAALVSVEDRRFYEHQGVDWKGTFRAALTNQFSGSVTQGASTLTQQYVKNYLVHVVARNNQVEQQKAQEQTIARKAREARISLQLERKLGKEEILARYLNVVPFGSTIYGIAAASQAYFNTTADKLTVPQAAMLAGMVNSPSALNPEVFPEKALERRNQVIDKMVENDKLSREAGAVAKQEPLGLADPVRTPPNGCVGAGPENGFFCSYVVNYLERNGFSVEQLKTGGYTVVTTLDRAITTTAKAAAEAQVSKSTDGIANAMAIVKPGRERHEVVALVANRDYGLKADQFQTQYDLPSGVENKFGAGSVYKVFTAAAAMESGMGYENMMATPNFYESKVFKGGGERCRSTGEPNTRWYCLGNASSGYPAQMTLQTALQTSPNTGFVILEEHLGMNPVVDMASRLGMRETMATNLRGERPDPKAKDKQLRVSQSEFYKADGGNASFTLSPAPVSTLELANVAATLMSGGTWCPPTPIVEVTDRNGKQVPVNEAPCEQVVAEGLANGLVVGMSKDSVGSGTASDAARKFKWDRPMMGKTGTTEEYKSAAFIGATPDFAGAVQTFNDGTRPRGICVGGVPRLCNEGDIYGGTVPARTWFDSMSRIHSGLPPKPLPEVEERYRKGGKEIQIPNVVGDDVNSATQTLQDAGYKVTTVNRNSSERKGTVVSQTPQGSALRGTVVTLFVSTGYVPPPAPPTSTEPSPDPDPDPGPPTGGPPGPGQPPGFPFPPWPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAX2</accession>
    <name>A0A7W7TAX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22793" checksum="9EEB36D4E285B6E1" modified="2021-06-02" version="1">MTSSTPLRRQPVQQRSAKRVERMLEACASLVEEVGYDGVTTTLIAERAGVAVGSLYQFFPDKRAVVQALTMRNLERFMQTVDGKFGTSQLEHWWDAVDSIFDVYVTMHRDVPAFSKLHFGDVVDMRLLDDRKDNNAVISDRIAEMIAERFGIPFAQIQLPISIAVEAADSVLNLAFRRDAAGDATILGEAKVLVRGYLSTRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAX9</accession>
    <name>A0A7W7TAX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase (Surface protein transpeptidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05830">
        <property type="entry name" value="Sortase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042003">
        <property type="entry name" value="Sortase_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40585" checksum="FB9F267DEE707AE0" modified="2021-06-02" version="1">MSYDPPRGGTPGRGPRPERRGRPPSDAERTQRIGPVGGDTEATVYVDAFSGDLAPARPASPRPAPQRPVPPRAGPRRPPEPPTEVIPRVAAATEDESVDDDGVSPAASDESPPPPPPDGPVRKTIRAFGELLITAGLVVLLFVVYEVYVTDLISAGKQEDATTALDQQWDSNTVEADPQRQAQYDLISGQAFAKMYIPVFGVDYKFSIVEGTTDPDLQIGPGHYVGTALPGQPGNFAVAGHRVGKGAPFNDLDLLSSCDAIVVETQTQWFVYRMLPTSKEAAGWAEGKGRSARCAGVTPLQGDYSRTVGQEIVTPHQGEVINTVPHVDGDPAGDKLPLMTLTTCHPRFSDKQRLIVHAVFVKGYDKKPGFIPDELKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB02</accession>
    <name>A0A7W7TB02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15986" checksum="D557E10A291F6F5C" modified="2021-06-02" version="1">MAITKGHRFPISFDDAFPQGLVMVGDVMPDVEYQTREDKAAGRPARQRMDETTGKRQWKVSVTDPHEPNAKRKSFEVTVLADVQPVPSTSEVLPGMRPVEFEGLTAEPRVAGTGEFKYQTYLFRATGFAGSGRGAGGKGAAAEPSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT72</accession>
    <name>A0A7W7WT72_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="459"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="822"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="482"/>
            <end position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="840"/>
            <end position="847"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1130"/>
            <end position="1137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1332" mass="146125" checksum="ECA4BCBC36BFA37D" modified="2021-06-02" version="1">MSTLQFKRTARLAAPRPPGGEVHLEPPPEVPRVIPGNIMMKALPAVMIVSSVGMMVLMFSYSNKNPAAMIMPGMMMISTIGMMAGGMGGGKGQKKAEMNEDRKDYLRYLGQMRDRARESADEQRAEREWVHPDPQMLWSLATTRRMWERRQNDPDFCHLRAGRGSQRLATRLVPPQTGPVEELEPIATLALRRFVRAHSLVPELPISIALRGFAAVGLLGEIEERRGLARALIAQMATFHSPDDLLIAVVSTGQAKQHWEWAKWLPHVQHPSIVDGIGQLRMMAGSLAEAEQMLDEQLRDRQRFTRNAPPPSDQPHVVIVIDDGDVTREEQILLEEGLVGVTLLDLSESLGNLTARRGLRLVIEDGRLGARSAGGVEWFGAPDWLSVVEVEALARRLSPYRVGGVDTGGSDEDPLSSNPALLELLGIPGDPMTFDIQQAWRPRPVRDRYRVPFGIGEFGQPVELDIKEAAMEGMGPHGLCVGATGSGKSEFLRTLVLGLLATHSSSSLNMILVDFKGGATFLGLDSAPHVAATITNLAGDLTLVDRMKDAIAGEVARRQEILAKGNYKNVWDYEKARENGAPIEPLPALFICIDEFSEMLTAKPDFIEIFLQIGRVGRSLQMHMLLASQRLEEGKLRGLDTYLSYRIGLKTFSAAESRAAIGVPDAYELPPIPGSGYLGVQGSPLTRFKALYVSGPYRPAGLQPAGPSVAVAGNKLPKFFVPEYVEIPKEPVRPAEPVQQQKKKEESLEPSELEVIVKRLRGQGPDPHKVWLDPLDKPPSLDGMLPPLQATDDRGLTAPGFFANGKLQVQIGTVDKPFEQRRDPLWADFSGAAGHGAIVGGPQSGKSMVLRTLVTSMALTHTPEEVQFYCLDLGGGTLASLENLPHVGGFASRLDVDKARRMVAELSGLITEREQRFRAQGIDSMVEFRNRKRRGEIRDDDFGDAFLLVDGWMNFRQEFEVLEPQVQALAAQGLSYGVHVVVTANRWAEIRPAMKDLLGTRFELRLGDPTESDVDRKVAVNVPAGRPGRGLSPQKLHFLTALPRIDAQEDPETVAQGVQDMVAKVSGAWRGRRAPQVRLLPDLLPHADLMNRVQQTAPNRGRLVPIGVNEDELAPVYLDFDADPHFMCLADGESGKTNLLRTIVRGIMTSYTSSEALILLVDYRRTMLGFIDTDHLLSYAVSSAVLADNVKDVRTSMTGRLPGPDVTQEQLKNRSWWKGPELFVIVDDYDLVAPQGGANPLQPLAEFIPQAKDVGLHIITVRRMGGASRAMYDPILGKLKEISAPILVGSGSKEEGAIVGNLKPSPQPPGRGTLVTRKAGQQRVQIAWIQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTD0</accession>
    <name>A0A7W7WTD0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="527" mass="55615" checksum="EC55341DA923B688" modified="2021-06-02" version="1">MTDDGRLVAGRYRLGRRIGSGAMGIVWQAHDERLHRTVAVKQLLLQPGLAEADTDEAKRRAMREGRIAARLQHPHAIAVYDVAEDDGQPWLVMEYLPSESLSTVLSERGTLSARDVASIGSQVASALAAAHNAGIVHRDIKPGNVLLGNDGTVKITDFGISRATGDVTVTATGMLAGTPAYLAPEVAKGYDPGPPSDVFSLGSTLYAAIEGTPPFGLNENTIALLHQVAAGKVQPPKQAGPLTALLMRLLRAEPEDRPTMAEAREALAAVAAGRSAPEFPVAVPPTHPPSWQGKPVSTPQTAATRPVGPPPAQNKPQPNATRVAANPVLNQPPRQAPPNRPAPRPAVKAAPPARGKRSTVFTALAIAGAAVVGILLASMLSDGGPESKAGADTSTTQPAGGGEPSVTTTSKKAPPPMQTITAEPSADQQEQAVRDYFAVLPQDVDNGWERLAPEMQSAIGGKDAYAKSWKDVTGVKITNLAMHGPYAYDVTYEVTNKDKSVTKDRKLFILKWASTTLYISRQDKLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTK4</accession>
    <name>A0A7W7WTK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aklavinone 12-hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.180" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="510" mass="54504" checksum="09BBF479B99ACDBA" modified="2021-06-02" version="1">MRGDMKVQVLVVGSGLGGASTTLFLARLGIHVLGISKHRGTMPHPRATGQTYRTMELLRVGGVADEVRAGGATGGMVIRIAESLGGPVFRTIVHEEDEIDGGLGPEPYAMASQDHVEPVLVDRARELGAEVRFHTELRSLRQDADGVTALLLDRGTGEEYTVTADYAVGADGGRSLVRTLLGVGRQGPGHLATHIGVIFRGDVGADVGGGRFTLYYLRNPAFTGAFATAHSWPHNLFTVEYDPGSGQTPADFPPERCVDLLRVATDRPDLRPEITAITSWEMSAWVADAFRVGRVFLVGDAAKVTPPTGGLGGNTAIGDGYDVAWKLAAVLRGEAGPGLLDSYEAERRPYARRIVDGSFHNYVERFAPHLAGPDVPAAIDHDTLIMGQRCRSGAVLVEDDDELEDPRTATGRPGFRVPHVVVGHAGRQVSTVDFTGEWTLLTADHAAWRDAPVRVPELDDPEGLLARRLGTGPDGASLIRPDGVVAWRTRAVPDDPATTVTRVLDAVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR3</accession>
    <name>A0A7W7WTR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="599" mass="64717" checksum="A6B00887F03F086F" modified="2021-06-02" version="1">MRVDVLGPFRVSHHGVVVTPTAPKLRQVMAVLAVSANRLIRTDQLIDELWPERPPASAMTTLQTYVYQLRKFMRLGNPGDGGPREEAVALTTQPSGYLLRLPDDAVDAVEFTGLARLGRAGLAADRVDEAAAVLRRALDLWRGPAFADVPAGPLLRSEIVRLEELRKSAVEVRVDADLKLGRHHDVIGELTNLVAAEPTHEGFQGRLMLALYLAGRRSDALRVYQNTRDSLSAELGLEPSAELRRLQRRVLDADGSLESSFLRPTTRAAAVEPPAQLPPTVSGLIGRERELGEVRDVLVRRRPGGVAPVVVVTGPPGAGGTALGLHAAHLLCETYPDGQLYARLGDVGPAEVLAAFLRGACHRELPDDLKERSDLFRSWTARRRVLVVLDDVVDTDQLTHLLPAGSGCATIVTSRRRIHSAAVSRVVDLAPLADPDALALLVRELGSPRVRRELADARRLVEFCGGLPLALRAAAAVLRVRAHWPLARLLREDKPAVWTGLGESVGTTCDLLADAVRTAFHTLAPAAAVPLTPTAAAAVLGTSPGVAEEVLESLVEHHLAEVVTIGPDQFHYRVPRPVRLAVRGCVRPVRPAPDVRKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA9</accession>
    <name>A0A7W7WUA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19257" checksum="C250DB5E79BDDBCD" modified="2021-06-02" version="1">MRHATSHVPVPGGPDELHRGLSAFGRTQAGQLVDDLADLRPDAIASSPYLRAVQTVEPLARRFGVTVTTDAALREWESGLEPRPDYADHYARSWADPDFARPGGESLAALSTRAVAALRVLADQHAGGTVVVGSHGTFVARALAGFGVAVDWPFSAAMPMPAVYRLSFSGMRFHAEGPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUE6</accession>
    <name>A0A7W7WUE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)/FAD-binding protein YdhS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="603" mass="65405" checksum="D031AEC657DB817E" modified="2021-06-02" version="1">MTVPVVVLAGGGPRAAGLLERLGANASVFGGPLEVHVVDPFPAGAGRVWRHEQSGLLRMNSMAEDVTVFTDDSVVCEGPIVPGPSLAEWAAGPALSEVDLDSEVRAELLALTPRSFPSRRVQSAYLKWFLGVAAASLPEGSVVRVHPHRVVGLDGDSAERQRVRLDGVDEPIVADVVVLTLGHLDNEIDPEHAALAAYAAEHGLTYLPPDYTADTDLSAVPAGEDIVVRGMGLAFVDLFVLLAEGRGGVFERVDGTLVYRPSGREPRLHVGSRRGVPYHSKTGYKLQGVPPEPPKFFHAEEILALPGDLQFRSQLWPSMARDIAYSYYRELFTGHPSRVTTDWETFSARFGELDWYSDGMRELVARSVPADEDRLDFERLDRPIAGVVFDDSAALQEYLRGYVEADVARRSDTAYSADLGAFFGLLGVYGQLPGVLASGRLRGDNGWWHGFFSYQASGPPPERLEELLALSRAGIVTFLGADVWVRAEDGVFLAGGASVPGHVVRARGLIEARLPEHSLDRTADPLLRSLRDAGEVFDAEGQVRVAADDCRVLDASGVPHARRFAIGPYTNNKAYAAFARPRTNAPAFRQNDLVARAVLKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUE7</accession>
    <name>A0A7W7WUE7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">F4559_001066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="497" mass="51768" checksum="E9790ADDD18D7A5C" modified="2021-06-02" version="1">MSDLIRENASDLAAKIASRETSAVEVAQAHLDRIDQVDGAVHAFLHVDREGALAAARAVDQDIADGRPVGPLAGVPLALKDVLTAEGIPTTAGSKMLEGWRPPYDATVTRRLKEAGVVILGKTNMDEFAMGSSTENSAYGPTRNPWDLDRIPGGSGGGSSAALAAFEAPLAIGTDTGGSIRQPGAVTGTVGVKPTYGGVSRYGLIAFSSSLDQAGPCARSVLDAALLHEVIGGHDPLDSTSVDVPVPPVVAAAREGANGDLTGVRVGVVTQFSGDGYQPGVLRSFEAAVAQLKQLGAEVVEVSCPSFDFALPAYYLIAPSEASSNLARFDSMRYGLRVGDDGTRSAEEVMSLTREAGFGPEVKRRIMIGTYALSSGYYDAYYGSAQKVRTLITRDFASAFERVDVLVSPTTPTTAFRIGERVDDPLAMYKADLCTIPANLAGTPALSIPSGLSDEDGLPVGLQIMAPALQDHRMYRVAAAYEVARGPIGSAPEPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF7</accession>
    <name>A0A7W7WUF7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21213" checksum="4EA0B471CB70CBD2" modified="2021-06-02" version="1">MNLSEAGRILATAISLDPKMPQPDAKGFIRGVWQKALHDVPYEDAEKAVFAHYRSDEYTRHRETISPADIVQWWNARRRPTERERSGSTGARAIPAAPFDPERLHAGVDRAVAALRAGKRVRAGSALAVAEREGVRESTARRRVLARPCGYCRAQVGEACVDGRGRKLTKSEAHPSRLVGAEVTPRARRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH9</accession>
    <name>A0A7W7WUH9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-aminoadipate transaminase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="39796" checksum="4A700B51AFCF6584" modified="2021-06-02" version="1">MRALNVRSSPVRDLLALVSRPEVISFAGGLPAPELFDVDGLRAAFDRAVSRRTLQYAPTEGDPDLRASIAARLTGRGLPTDAGQLLVTSGSQQALTLIATALLEPGAVVAVEEPTYLAALQCLGLAGARLVPVAGDEHGLVPESLAEVVERSKPELLYLVPTFANPTGRTLPAARRAAIADLASRHGFWVVEDDPYGELRYAGEAVPTLASFGDRVLHVGSFSKVGAPGLRLGWLRAPADLLRALVVVKQAADLHTSTIDQAAAATYLAETDLDAHVATLCREYGVRRDAMLAALPGTLPAGSTWTTPDGGMFVWAGLPGDVDAAVVLERALKHDVAFVPGGPFFATTPDHSTLRLSFTTNTPERIAEGMTRLSAAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ3</accession>
    <name>A0A7W7WUJ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20169" checksum="0CE41EB3259AC663" modified="2021-06-02" version="1">MSPALESVLAKAGLQVTPDEFLDLVADAARRLAPPHPEPAGYFTPDQRAALTDVGLDLSPVTGRDDRSRARTVVAHAVLRDSALSVAEAARTLGVDTSRVRHRLGVGRLVGWKDRGSWRLPAWQFAGAGVLPGLEVVLAAVPADQPALVVAGFMTTPQEDLPVDGVPAAPRDWLLAGGEAARVAALVAGLGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX1</accession>
    <name>A0A7W7WUX1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6709" checksum="5E739A0661D0877A" modified="2021-06-02" version="1">MGLNDVDTSAYVQIREGAPITFEVVGDQVQIGFGSTFDLAMTPKAFTKFAGVIRAAQGELTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY1</accession>
    <name>A0A7W7WUY1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="19637" checksum="5F71B7B548AA668B" modified="2021-06-02" version="1">MTAVAVAPRSLVVLAGLPGAGKTTLLAGVDTGGASAVVLDSDQVRSRLRALLPSTLPYRIYRPVVHLVHRLRIVWFALTSSGLLLVHEPSTRGTTRIGLVAVGLLTGRARHFLWLDVSPEEALSGQVHRGRLIRSRSFSRHVRRAQRLRVLFAAGRPPRGWQALTVLTRADRLRLSVTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU3</accession>
    <name>A0A7W7WVU3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030540485" evidence="1">
        <location>
            <begin position="34"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17056" checksum="CF2B8BC4CAA4F8BD" modified="2021-06-02" version="1">MRRRPAGGPFGLRVLMAVLLGLTGLVVATPYAAAGPCSWPGCAYSVNETDLWTAVLRNWCWPGETGDSKGYFLGCAQSGVSQDLSFLSPNGGHTPPSQAWNVLRVDAGWCYKVHFERYWSSSFTRIYDQRGRADLYVMVGNEAKAHIQGQGYSSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB4</accession>
    <name>A0A7W7WWB4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="39095" checksum="0B7318EB26EA6CF1" modified="2021-06-02" version="1">MGSRLERLSDGLLVLLPLMVAWLSVVDDERNRVLVLAVGTVQSLALAWCRRFPLAVLLVVTALETTLVVLDREMLVGFLAAASALGTWGKPVQQRVGLAVGLTLLACGVVSSVAGGAPSGFALAGIASVALMFVGFWLSGRLGARQRTRIDRFEAERAEAERRAAERERALLARELHDILNHSVTAMVLDATATAETGSAAETRAALDRVARTGRDALGELRRLLGVLRTTAVDYDPLLVPPGLDRIEELIETTPGLRITLVRSGTAGPVDASIGHAAYRVVQESLTNVAKHAGRVETTVELAFTADRLLVVVTNDEPIVPPNPGTGMGLVGMKERVSLVGGTLTTGPRPDGGFEVRAVLPTRTTECPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWD7</accession>
    <name>A0A7W7WWD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22135" checksum="416720B24A7603CE" modified="2021-06-02" version="1">MGHELLRVAGLRKDHGGDPVVDSVDLTVYAGEAVAIVGPNGAGKSTLLRCVVGADRPDEGTVLLEGRPVDDTDPAHRAALAVLLDDVEHFPDLSVVEHLLLYAWAHGEADADRVVDRVLAEVGLDGVRDQLPGTLSAGQHHRLGLASCLVRPRRVLVLDEPEQRLDRAGRAWLADRLNREKAAGVGVLFSSHDATLIDTVADRAVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT8</accession>
    <name>A0A7W7WWT8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23208" checksum="524401F1ECC053A1" modified="2021-06-02" version="1">MIRVVLADDEAMVRAGVKAILLADPGIEVVAEAGDGHEAVELVREHRPDVAVVDIRMPGLDGFDTTEAIRRACEGTAVIMLTTFPENAYVTKALRAGANGFLLKSGDPRELLTGVRAVSEGAAYLSPKVAARVIDTLGSDRMARSGEAREQVDGLSPRERQVLALLGAGRSNQEIGRELHLVEGTVKSYVSAILGRLGVRNRVQAAIIAFEAGLVTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX99</accession>
    <name>A0A7W7WX99_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="800"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="5">
        <location>
            <begin position="886"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1017"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1045" mass="110638" checksum="C39C8C020BE27AA6" modified="2021-06-02" version="1">MATTPHSSRRKSRRRTRGRAWKGAGRVLRALGRLVRGVLAATVLAALLAGLPWALTHFVGWPLPDHLPSWAEVQGVLLGPMTTTFLLNFLACATWLVWAFFTLDVARCAVEIAHDARMPDLSAAGPVHRIAAVLVGAVLISILGQRASLPATSPAAGGAAAEVVATAPAWSTPAEQGKFAVVRPAAYSAPEHHVATRAVEQASRVKSAVVLPYNPDTGVYDSLWRMSERTLGDGNRWPEIYALNKGKPQPNGGTFTRPSLIFPGEEMALPDDATVSSPPAPAPVQPPIIPPPAPEPPPSSTATPAPSTTQPPVTTEAPPTTQAPSATQAPPSTDAAGEPGISWGEELFVGLGLAAAVSAALVAARRRNRRRYQPGSGDRSDLPVAPVVYQLRLAHLRADHDTTSANDEVDLDWPTERPPRAPAPPLVLGTHADVSDVLDDQAAVLPVGVRDGREIAVDLASAHGLGLLGAGAPAAVRALLVAILSTAATTDRPATVIVPADALAVLFGRRVAQAPLPAGVRVAADLDAALDMLESETLVRVGQLPPTGQPWEPVVLAARAPGRQARRLQAVLDNGSTVGVTGLLLGQWSSGVTAYVRDDGTISTTSPGLGEPLCGARVFRLGDDHLADLLDLLHQTDPDVEPETAVDEPRPAVVPRPHVVVDDPGPGASTDDRGPAGSEHTRAESTIQAPVADTDLELLAASAENDRRSDGELEILRPEPAPATSLGLRLRPVQPVRSDVDPTTQNAGEGHQPGLSAGSRPQGPAEPREGASAPLHVSVLGPPRVWWRPTPATPDGETAEREITSAFQPRLRELLVFLALHPDGASREALIAALWATSPPERTTNAMNTALSRLRRALAAATGNALSDLVVVGEGRYQIDPELVEVDYHHFAAAVAARRAAVTDADRVEAYRRIVDCYTGPLADGLSTDWIETAREAIRRDAIDAVAALARALVEDDPQQTLDLLEIARAFDPHNELIYRDIMRLQERLGQLDAIPRTLTLLTTRLAEVDDRPTHQAVDLADRLRRRHEAPGEPGRADRGHSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF1</accession>
    <name>A0A7W7WXF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding universal stress UspA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="155"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="30229" checksum="741E3352427C7D0B" modified="2021-06-02" version="1">MSTPEQHGTGAVVVGFDASKRAWDAVRWAAAEARGRNLKLVVVYAVRNGLPEVAFTPTPAPLPQLIGDEVVHDYARDKLAEVTAEFPDAEPLLLDGHPADLIEQVAEEGELLVVGASGATGLARVVTGSVAAHAVHHARTPVVVVREGGVQDGPVVVGVDGSPTGARAVEFARDHAARHGLDLVAVHALTTQPFEVLGPTQGWEYDPAVAQSGAEALLAESVPDGRVPVTRVVAANRPAEALIEWSERASLVVVGTHGRGAVRRALLGSVSHALLHHAVCPLAVVRAPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX1</accession>
    <name>A0A7W7WXX1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="204"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="261"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="519" mass="53452" checksum="10E9AFA6EB04BA23" modified="2021-06-02" version="1">MTIRLRVLGCAVVGAIAIGVIIAVAAFVNGSQSRETATLARVSAAMSAQWNADMMHDGLRADVMAALYATSDEQRGALGVEETAEHVSDMLSDFDQAASLAPASLLDEFKTVRPLVVDYTALAQKVVDLARTDHAAANAQVDAFMTMFSSLEDKLGTLDDDLGAAVEEQRRLADAAGLSGLGLIIACGALAVVGFVLLAWWTFRAIDRPMKAMVRALKALAGKDLTQRVEVVRDDELGEMAGALNDASASIREVLVTVRSDADALLGAGGDLDAVSRRLGQAVDETVTRTGEATRSAGQVTDAVGRIAQASERISDAVRSVSSASSTAVDSATGAARTAETAASGVERLRVASAEIGEIVGAITSIAEQTNLLALNATIEAARAGAAGRGFAVVAAEVKDLAQETARATENVKNKIGVIQQVTGETVGSIDGICTVVGRINDDQQRISSAVDEQSRTTEGIVTSVGEVGTITSDIQAHLDGIASSASSTADGAAATRASAGTLTTTARRMNDLLGGFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA1</accession>
    <name>A0A7W7WYA1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="285"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="605"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="679" mass="74200" checksum="34B5EEA91390E978" modified="2021-06-02" version="1">MPDGLDPEQRAAVEAPRGPVCVLAGAGTGKTRTITHRIAHLVVRGHVAAGQVLAVTFTARAAGEMRTRLRALGVHGAQARTFHAAALRQLRYFWPRVVGGPHWQLIDGNKLRLVAQAANRVGLSTESDSLRDLAGEIEWSKASLIAPESYPLAAERAHRDTPAPADQVVRVYQTYEQLKNDACLLDFDDLLLHTAAALEEHGEVAEEFRDRYRCFVVDEYQDVTPLQQRVLDAWLGPRDDLTVVGDASQTIYSFAGASPRPLLDFPRRFPDATVVRLERDYRSTPQVVGLANNVLRFARGRPAGSRLRLVGQRPDGPEPAFTEFDDESVEAAAVAQRAKALLDAGVAASEIAVLYRVNAQSELFEQALAELGIPYQVRGGERFFQRAEVRRAVLALRGAGAPDGGLPDVVRQVLAPLGLTDEPPTGGAARQTWESLLALVELAEEFAATVESADLPAFVVELDLRAEAQHPPTVEGVTLASLHAAKGLEWDAVFLVGLVEGTVPILHADGDEAAIEEERRLLYVGVTRAREHLWLSWALARAPGGRRYRRRSRFLHGLVPEDHPAALVARREPAQRRPRPRCRICDSQLTDTRGVKLGRCVTCPSDVDEDLLTRLRSWRAGRAKELKVPAYVVFTDATLVAIAEQRPEDVAGLVTIAGIGAAKLDRFGADVLALVQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF0</accession>
    <name>A0A7W7WYF0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein YphA (DoxX/SURF4 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14362" checksum="19C9FED66CA7D787" modified="2021-06-02" version="1">MDVLVLIGRILFVFLFFGSAIGHLTQTEAMAGYAASKGVPQPKLATAGSGVLMIVAALMLLLGVWADLGALLLVVFLLPTAFLMHDFWKQTDPQAKQQEMIAFNKDLSLAGGALMFFGVYAGVGADLGLTVTGPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG4</accession>
    <name>A0A7W7WYG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="7">
        <location>
            <begin position="279"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="42065" checksum="F73221092B5CAD9A" modified="2021-06-02" version="1">MPEAVIVSAVRSPIGRAGKGSLKDMRADDLTVQVLRAALAAVPRLDPATIDDLMLGCGLPGGEQGFNLGRVVAVLAGYDGLPATTVTRYCASSLQTTRMALHAIKAGEGHVFVSAGVEMVSRFARGSSDSWPDTHNPAFADAEARTAAPGPSWTDPRERDVLPDVYIAMGQTAENLALAKGVTRQEMDEFGVRSQNLAEEAIANGFWAREITPVTLPDGTVVRADDGPRSGVTYEGVAGLKPVFRPDGRVTAGNCCPLNDGAAALVIMSDTRAAELGITPLARVVSTGVSALSPEIMGLGPVEATRRALANAGLGVADIDLFEINEAFAAQVIPSYRELGIDLDRLNVNGGAIAVGHPFGMTGARITTTLINSLRFHDKRFGVETMCVGGGQGMAMVLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYP5</accession>
    <name>A0A7W7WYP5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32564" checksum="C266064917EFCAA5" modified="2021-06-02" version="1">MIEAVGLTKVFGRKVAVDDLDFVVRPGTVTGFLGPNGAGKSTTMRMVLGLDRPTAGTATVNGRAYAELHHPLREVGAVLDTRIAHPRTTARDHLRVLAVSHGIPVARVDEVLDLVGLTEAARERIGKFSLGMRQRFGLAVALLGDPPTLLFDEPLNGLDVAGVHWVRKLLRGFADEGRTVLVSSHLMAEVQGTADRLVVIGRGRLVADARTADFIADTVGVRVRVETPDARAFVDALTAAGADVDQVGTSVLLVSGMERHAIGDLAARASLVVHGLADEVASLEEAFLDATESSVEFRGKPEWNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ48</accession>
    <name>A0A7W7WZ48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="6828" checksum="B17F8F3415ECD59D" modified="2021-06-02" version="1">MELSRSNSLTIRQAAWLLGCGEAGVWRAVRTGLLPTVAGRGGVIRVPACAVARLVESPERGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZS1</accession>
    <name>A0A7W7WZS1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="20394" checksum="52C1DFB139E9B29A" modified="2021-06-02" version="1">MTTWFLALVSAFVAVFVLELPDKTTALTLVLTTRYRSAPVIAGAAVAFTLQAVIAVALGSALTLLPERLVAGAVALIFGIGAFLLFKESFDHDEEEGGAAARQSVPFGRAALASFGALFAAEWGDASQLAAVGAAAKYAEPTAVVLGTFLALMCVTLLAVAVGRRIRDRIPAHWVQRGAGVVFAAFALIAAYQAIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X023</accession>
    <name>A0A7W7X023_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LPXTG-motif cell wall-anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031229078" evidence="5">
        <location>
            <begin position="32"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="6">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="431" mass="44007" checksum="C269DEBE4C0C03A7" modified="2021-06-02" version="1">MKRGIEMKKIAFGAALFALASTTVMTIPANADEVAKGAIEVTTFADHDGNGVQNGDEGGYTPVTADIKNIATGATTRVQTWNGASVVADGLAVGTYEVSTPEVADFIGTTPRKLTIEVTADSTVPAKFGYQGGTVVGSTWIDENGDGLRQAAEPPADSVSFVLLDPAGVVIDGAMSDSDGKFAFRGLRGGEYRVQRSSDDPLLPYAVGGGDSAVDPTTGLTGLIPVKPGATTEPVVIGFRKAIVNRTMNEMTIAGTPVVGGQFTMFFSATNNGTVPTDLTGGVVLPDGLVAMAAEGPNVETDGRVITFGGDEVLFAPGESVSVWVRVRVDRMVAYPEISFGVNQKDEKQSDVGDNHRLVMIDIAAAPTSAAPTTTVAAPAAGAPQAVVPVAQTKETGSLASTGASPLIPLALGGVLLLGGTGALIAARRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY42</accession>
    <name>A0A7W7SY42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell filamentation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21811" checksum="268C238A5C0ADA84" modified="2021-06-02" version="1">MTFADPYRDPGTGVLLNNFDISDPRVCEAAEARLSALRIAELELTPLPGLYDLPHLCRFHRHIFGDLYPWAGKVRRVDIARTAPFASWRQIEPYASGLFEELRKEQYLRGLARAELLDRLAHYYVEVNALHPFREGNGRAQRAFFAQLLLEAGWRLDLTALDREAFVAACRLGMSGPSEPLRSLFEDVLVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY48</accession>
    <name>A0A7W7SY48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9415" checksum="1FF204936715E2C3" modified="2021-06-02" version="1">MVLAGAFTVAGTATATASEHAYVAAQPTDTVTPSVTGPDIDAPQQTDPTVASETKKKLWIGGIALVLFALVYLRNRKRWTNWRKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY61</accession>
    <name>A0A7W7SY61_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="540" mass="57516" checksum="95EDAF5C73A4917F" modified="2021-06-02" version="1">MDTERLIGGRYRLRHVLGRGSMGTVWAAHDEVLRRAVAVKEMLHPPGTPEPEAEVLRERTLREARSAAALAHPNLVTLYDVVRHDGEPFVVMELVPSASLAEVVRERGPLTDEQGAVVADAVAAGLEAAHRAGITHRDVKPGNVLVADDGRVKLTDFGIARNVAEATLTSRGITLGTPAFIAPEVAAGGDVSPAADLWSLGATLYAAMTGQDPYEGANVMQTVNQVIHADVPDLGVTGGLEPVIAGLMVKDPQARIPLAEVRRLLVDTLPEPGANVFPSDGPTRPVVEVVRRPPAKPVIAPDTPLASDPGPLPFTLTPERRRPVSKPVVLLALVLFVVASVGGFAATRTLAGTSPLPPATGARPTVSPLPDDLPLQPVRASAAAANGERDTEFGLSVGVDWTQFVEQRLHQILPPSTVVHFVSPDGVYEVTVQKFTVFYPKLTDEDYVKAVAERWGPDRIFGQAVTPSTGGILFSYRTVEQTTSTGPGRGAEPDLRRSRYSRLVPAGPSLWVVEVSFPTDQEEAGRTRLFGPIANSFTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYC1</accession>
    <name>A0A7W7SYC1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Coenzyme F420-0:L-glutamate ligase/coenzyme F420-1:gamma-L-glutamate ligase</fullName>
            <ecNumber evidence="12">6.3.2.31</ecNumber>
            <ecNumber evidence="12">6.3.2.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_000534</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="12"/>
    <dbReference type="EC" id="6.3.2.34" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01259">
        <property type="entry name" value="F420_ligase_FbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019943">
        <property type="entry name" value="F420_FbiB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023661">
        <property type="entry name" value="FbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03553">
        <property type="entry name" value="F420_FbiB_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="10">
        <location>
            <begin position="262"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="448" mass="47155" checksum="9A0DBB814045C3C9" modified="2021-06-02" version="1">MTDLSARDHAAGSVTLLPVNGLPEFRPGDDLAGAIASAAPWLRDGDVVVVTSKVMSKVEGRLVAVPTDPDERDSVRREWVRAEAVRVVAQVGRTLITENKLGIVQAASGIDASNVNGDEIALLPVDPDGSAAALRSALRGLLGVDVAVVVTDTMGRAWRVGQTDAAIGAAGLTVLHRYAGSVDRQGNALVVTEVAVADEIAAAADLVKGKLGAVPVAVVRGLAPVDDGSTARDLARPVEEDLFRLGTAESIAQGRREAVLLRRSVRAFTAEPVDAEAIRHAAGVALTAPAPHHTQPVRFVHVRAMRKALIDAMRAQWEEDLLGDGMSAQAVARRVARGDFLRDAPEIVVPFLVRAGAHAYPDERRSRAERTMFTIAGGAAVQGFLVALAAEGLGSCWVSSTMFCPDVVRSALELPSSWEPLGAVAVGRPVERLEPRTPRGSGEGFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYF1</accession>
    <name>A0A7W7SYF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010958">
        <property type="entry name" value="Chorismate_mutase_highGC-bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01808">
        <property type="entry name" value="CM_M_hiGC-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9651" checksum="11FEFEE72F065D92" modified="2021-06-02" version="1">MNSTDTAPDIDDLRTEIDHLDAELLRLVKRRVEVSRLIGAARMAAGGTRIVHNREIDVLNRYRELGPEGRELAMALLKMGRGPMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ6</accession>
    <name>A0A7W7SYQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18073" checksum="4FEC3A5C1B129037" modified="2021-06-02" version="1">MPDFVPPVTDERQALLAYLAKQREGLLATTKGLTDEQLTLAPTVSDLSLAGLLKHAVRTERRWIVAGLAGRPLPDLWPITGWDREFVPDEDVTGLRVAYAEAARETEEIVGALPSLDEPCRLPDARQWSARWVLLHLITETAHHLGHADIVRESIDGAKAADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ57</accession>
    <name>A0A7W7SZ57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretory pathway TraG/TraD family ATPase VirD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="TraG-D_C" evidence="2">
        <location>
            <begin position="408"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="572" mass="61907" checksum="EF81F57EE29A670C" modified="2021-06-02" version="1">MTPRDDLVRLVAMLSLGIGGVFGLVTGGALAALLGGHGWVWRDDGALATLLRDPDNPGRAFGHPDTDPVLWWIVVGVLEIVVAALVTLGAARFHGQESPMATRRQLRLALGARAARRRAGRARPSLAGTGRLPMSEVAVDLGRAAGLNLFGQHEDAELVMVGTRQGKTNRRIIPRVLDAPGAVVTTSTKADVLAATVGVREQVGPVHVFDPEDVTGWPDTLRWSPITGCENPDEAIRRARELVAARPMDGTVTNAGFFTDSATRVLRAWLHAAALGGRTMRDILTWSAQWSDDEPLDLLHRSPTSAHWASTLRELTTSAAGEMLGGIAQTLNLVLDPLNSPRLLDACSPPRGREFDVDAFLRSRGTLYIVSEGGVGSAGPLASALALHVHHRAKRLAARQPDGRLDPPLRCPWDEIGNVAAPDNLGQLVSDSGGRGIHMIIACHGLGQLERRWGREQTREIWNSVTTRLILGGVAEADTLEDLSRLVGDAYVPRTSTSTGEFRRTRSTTHNWERALRVDQLRTLPDGKALLLYRNLPATTVTLTAWYDQPDSKRLLALKADAEHRMGRRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ76</accession>
    <name>A0A7W7SZ76_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006765">
        <property type="entry name" value="Polyketide_synth_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038474">
        <property type="entry name" value="Polyketide_synth_cyclase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04673">
        <property type="entry name" value="Cyclase_polyket"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12812" checksum="C749A357F779BC2E" modified="2021-06-02" version="1">MHRTLIVARVDPRDTDAVAEVFAESDATALPARIGVTGRTLFRFHGLYFHLVEADEDIRRNLYAHRDSALYQDVNTKLSRFVSPYDPDWKEPADAMATPFYRWTAQDGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB8</accession>
    <name>A0A7W7SZB8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="5899" checksum="4B1AD3DBD68FE3A3" modified="2021-06-02" version="1">MTPAWTVAVLLAGLWTAPVAVLRAAVRRADDDAFTAALPYPRARCPHRDLPGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF5</accession>
    <name>A0A7W7SZF5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16274" checksum="3A545C8C8D6B6E51" modified="2021-06-02" version="1">MTIVAAQTAVEAVATAWRALAKEATESNQAWQDLRDPTRPWQQSLLRHRDQHHHLGKAAQRLVKALRDIVREAHTAQARPLLGEHPELGGRITLDSAEPDGQEWVLVRPVADYLDLPDRIVTIGHAYAESAQDRRTYLVDAGLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN2</accession>
    <name>A0A7W7SZN2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S27AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8625" checksum="9007D1B1C618D11C" modified="2021-06-02" version="1">MSSVPDGIRQPVRHDLTTTELGARLHVVERPVFPCPRCGRAGWLAVHLHGVRRPCGHTRSLPPLTPTPAHHRHHRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS3</accession>
    <name>A0A7W7SZS3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsB</name>
        <name evidence="7" type="ORF">F4559_001312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="30718" checksum="AF4E5B3E87A9D354" modified="2021-06-02" version="1">MAVVTMKQLLDSGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQQTLTYIDRAYEFVRETVAHGGSILFIGTKKQAQEAIANEALRVGMPFVNQRWLGGMLTNFSTVHKRLQRLKELESMEQTGGFQGFTKKEILMMNREKDKLERTLGGIRDMSKVPSAVWIVDTKKEHIAVGEARKLNIPIVAILDTNCDPDEVDYPIPGNDDAIRSAALLTKVVAEAAAAGLMARSGVRTGNAGGGGAEKPEPGTGEPLAEWEQDLLVNAEAPAAEAPAAGSETVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T027</accession>
    <name>A0A7W7T027_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="31" mass="3384" checksum="EB86F11C34051DD4" modified="2021-06-02" version="1">MRISTQNTSSTLTALLLHNAADLDTLLVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T048</accession>
    <name>A0A7W7T048_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ParB family chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="50603" checksum="73FC7F19A9F808A8" modified="2021-06-02" version="1">MSGWENARFELVDPRVLLVDRNSRTVTDVERERPELCASIRRHGVVVPVIANPTGEGLRVRDGHSRTIVSRSVVERFPVIPVIVTEAADTEEWHWLRDQWIANEVRAGYGTGDRMRIFEELTLFGLGPDEVAAELGTDVEVVHAGLRARRSEAVVAAVERHPEMTLDQAAGLASFEDDEEVYRHLTEVLDRDPDTFDYALAEQREESRLRREAAELRERLAREGIAVVEEIVSGTLPLTRLRDQGRTVAPEDHLSCPGHAALVTSDDGDGVVRATWLCRDWAGHGHTDSWQATSEPHRPWDAERKAERAQVVRSNQAWRAAETVRRTKLRELLARSTPPRGALRFVVESLLAGDDELLRAARDRHALACRLPGLREPGAGRTHPLTSKLRGQDRLTTVLLAIVLAAYEQSTGPQTWRTPTPGQKRYFAALTKWGLARHWVEKLVTDIPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E7</accession>
    <name>A0A7W7T0E7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17645" checksum="7ABA6C3D1CD9D2EF" modified="2021-06-02" version="1">MTDLHVRPARTEELSDIGALTVAAYTADGLDPASGYVTVLADAATRARDAVLLVAVDPEGTCLGTVTVARHGTPYAERCRQGEVEFRMLAVAPAARRRGVAEALVRTVLRTARDEGAHTVVMSSKPSMTTAHRLYHRLGFTRTPDRDWEVFPGLTLVTFALGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M4</accession>
    <name>A0A7W7T0M4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="170" mass="18912" checksum="411E02759564BEF6" modified="2021-06-02" version="1">MTSEVIDDRVEVPFTGSEKELLSAFLDYLRGTIALKCAGLSEEDARRVVLPSPLTTAAGIVKHLRWVENYWFRVALAGEPSSAPYTREDPDADWRVEPGETISGLLADYAAECTASRSYVDGVELDHEVPFRGDRRLSVRWVLIHMIEETGRHAGHLDAVRELLDGTTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U0</accession>
    <name>A0A7W7T0U0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">F4559_001301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13401" checksum="9802BC61029B07C3" modified="2021-06-02" version="1">MNTLDALDAQSLRSDIPSFRPGDTLKVHVRVIEGSRERVQVFQGVVIRRQNGGIRETFTVRKVSFGVGVERTFPVHSPNIAEIEVASRGDVRRAKLYYLRDLRGKAAKIKEKREAKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W4</accession>
    <name>A0A7W7T0W4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19037" checksum="B338147500AADFF0" modified="2021-06-02" version="1">MAVLTRPEKLVGDVLIRTAVPGEEEVILDLLSEAAAWIIGLGIEQWPARFAAESVRVRIEAGQALLVGDPPVATLVVADEDEFWGDDPEPAYYVSRLTVSRSARGLGATLLDWVSGKAVEHGRHAVRLATASGNPGLRRYYEAAGFRHVADPPRARWPISLYERKVNPTTGSNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T111</accession>
    <name>A0A7W7T111_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17561" checksum="309E3C6ED0566D23" modified="2021-06-02" version="1">MSRVLLSLAVFAVFALIVFGMWRGWKARARRQAAFLAEFPAPPASTGTTMLETTGVYVGTTLGDDWQDRVAVGDVGHRAEATLRLTDTGVLVERTGASPLWIPVADVEGARTARGLAGKVMTADGLLVVRWRLGDRVLDTGFRGDDKDVYEQWVDALNPGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T173</accession>
    <name>A0A7W7T173_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="345"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="7">
        <location>
            <begin position="526"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="642"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="882"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="906" mass="95232" checksum="021B2812FF26DFB2" modified="2021-06-02" version="1">MTGENSAARGQWWNAVADWRNWRLPVKLAAVLAVPVLVAVGSGLVQIRGYIRSADSFASVQRVVTLRAGLDPLIANVQSERALAGARAEGEGVDVRKFKELVSLSDNSVAAVKNLMERTTTLGTVANARFRDVLVQLDGLPQLRDRVLTGGVDLAGGIAGYSVVLRALLDFDQAMTGDFGDPALSGTANALHNLAMAGEQVSWQHATVIAGISRGTLLPGERTAIEQSFTRQQDKLADFSAVATPEQQSQYKDALSGRDADTRTTLLQTVRDNPDAVGTIASADWSLGSEATLKQIGTVLRSLENELTTTASRLQDETSDRAGVAAVILLASLFVAGAVGIVVGNYLLRSLRALRTSALDVARNRLPELVDQLRKGDAAPDVEIDPVPVHTREELGQLARAFDAVHRQALDSAAEQAELRTAMRNAFTNLSRRSQGLVERQLKLMEELERQEENPEQLANLFKLDNLATRMRRNNENLMVLSGTDAARRFTRPVPLGDVLRAAGSEIEQYQRVVVQAAPQVDVVGYAAGDLVRLIAELLDNATTFSPPRSQVVVGGRTRPGGGVLIDVVDSGVGMSEDELVEANRKIAFAAFDDSAELPVSRQLGLYVVGRLAGRHGIEVVLKEQGDGLRAVVAVSGDLVRTGTSTPRSAPARPAAASAFAVPARTAGPSSGLPLPTRVAQPVNGARTATTGPQPVVPSVQLLGMPVGGQTGLTPATPPGSTGPQPGLPLPTRPAGPHHAAPDVVGADGVAPTNGVATPPRATPTSAPGSAPDGVPPTAPAPGAPTTPPVGGEEGWEPFSGTTVDPAAPETTPRHLSTWFGGGTVPPEVPRHRVPEASATEETGGLPKRRPRSNLMADRPDGPDTGAPVRRDPHATRGFLASYQTGIRQGVQESGESRPGQGREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T174</accession>
    <name>A0A7W7T174_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11498" checksum="3A0884FE56431C4A" modified="2021-06-02" version="1">MIRVCPLADLDDRKPVAFEVGDENTPVVLVRDGDTVHALRDLCTHAEVSLSEGDVTRKGIECWLHGSCFDLRTGRPSSPPATEPVDVFAVELRGGDVHVDVTTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T189</accession>
    <name>A0A7W7T189_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="6199" checksum="F15CB1B576B6F18D" modified="2021-06-02" version="1">MEWSPEALKAEIDYRQAALRAAAAHARVERVARRSRRSWWSRITHRDQRPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D1</accession>
    <name>A0A7W7T1D1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-carboxy-cis,cis-muconate cycloisomerase</fullName>
            <ecNumber evidence="2">5.5.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047472">
        <property type="term" value="F:3-carboxy-cis,cis-muconate cycloisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="1">
        <location>
            <begin position="330"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="41714" checksum="0A087A76B33497F2" modified="2021-06-02" version="1">MEAELGDHAWVRAMLDFERALAHAQDAPDVVVAIDALVPDPADLGRAAPVSGTPVVPLVGAIRAALPPDRRAAVHRGATSQDVVDTALSLVASRSLRPILAGLDAVADECARLARDHRDTLITGRTLGQHALPTTFGYKCAGWLVAVHEAADGLRRARDRLAVQFGGAVGTLAAAPADVTDRLAADLGLAAPTLPWHTDRTRIAGLAGALGTAAGVLGKIAGDVVLLAQTEVAEVAEGAGGTSSTMPHKHNPIRAVLVSACARRVPGLVASVLSAMAHEHERATGSWHAEWRPVTESLSAVGGAVLGTRELLSGLVVDVDRMRRNLDLTDGLLLAERVAAHVGADTVAELVRAGLPLREALAARTALSEHEIAHLLDPAAYTGHAGAFVDRALAAHRGRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L3</accession>
    <name>A0A7W7T1L3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="37462" checksum="E8DDAB9230C1076B" modified="2021-06-02" version="1">MLVTTTPANLELIRSALGRFADSFDHAETAYFGRLPAERATEFFRYGQRKAASVDNRNVRVLAEPLWHGRTERDVRSWRRMESGLNVLLEDTNVWMICPYDTRTVDEQGIEHAMRTHPTHVVGTRTLSSTRYVDPIEYARWCDATPLSPRPGHAAVLLLRGDPHVVRRFVVAEATRLGLDAERAALLTVAVGETLAYLRDDGYVATWAAAGSVVCELSGTVTAAPGLFAGFRPPELYTTTEPGDGLWITRQICEWVDIRHQRGRAVFRLQVPGPTSVERRVRRPGCPSACAGLSECVFQDARVRVPGVSEWRTRGGGGTAEPRGPRVSGGRPGCGGAGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S5</accession>
    <name>A0A7W7T1S5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="171"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="38394" checksum="6FBF3E4877A0E10F" modified="2021-06-02" version="1">MSNRLFRLLPNAYPVVLDTAFALCATAVYASFAGISSLSPWFGYPLAALIGLPLAVRRRYPLPVLAVVVTALCVATVLEMPLEPHSPTAFALYAVGAWVPRRPAVTALVATVVMSGAALMVSQPTPDDIGLVAFVGLYGSAAWALGRFTRARRAFAAREEAERATRAVTEERLRIARELHDVVAHSLSLITVKAGVAAHVARTRPDEVVDALAVIEATSRDTLVEMRRLLGVLRSDDATGTAPMPGLADLAGLVERAADAGVDVTLEVTGGGLPDGVGLTVFRIVQESVTNVVKHAAPARCSVRVAVTDDEVGIEVVDDGTRAARAGGGHGLMGMRERVAMYGGDFEADRRPAGGFAVKARIPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C3</accession>
    <name>A0A7W7T2C3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">F4559_001424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="31020" checksum="132D11B490392576" modified="2021-06-02" version="1">MTGCPTASPGRPFGRVLTAMVTPFDAQGALDLDKAQHLAKHLVELGNDGLVVNGTTGESPTTSDAEKSDLIRAVVEAVGDRATVVSGAGTYDTAHSVHLAQQAEAAGAHGVLLVTPYYSRPSQAGVYAHFTTVADATGLPVMLYDIPPRSVVPIEVDTLLRLAEHPRVLAVKDAKGDLVAGSRVLAATDLAYYSGDDPLNLPWLSVGAVGVVSVIGHVVGDRLLNLVDAYEAGDVAGARAVHEELLPLLKPFSRMPGVTWVKTALRLRGHDVGDPRLPIVPGDADDIAALSDVLGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D3</accession>
    <name>A0A7W7T2D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030808731" evidence="1">
        <location>
            <begin position="23"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="649" mass="68373" checksum="46CB6561210CC553" modified="2021-06-02" version="1">MRRVLVVLLLVLAALTAPDASAVEEGYTVATASSSYVEGDTAFDLKGDNVKHYISLPFPVMYYGKVVRMADIVDDGYLAFGHTPDVLGPDSGPLPSTNAPNGAVYAFWDDLVIDDAAAIRTKVDGVEPARRFVVEWHNVRLKADGSRLSAEIVLHEGGQIVLQYKGIGSPTEAGARAVVGIEDWSGSSAVVWSNRQPKLSDATAVRFRKPGMMVARGVLRNANDRTPVSLADLKTVVNGRTVTMYTIWDGEYWFEVSTRGAVIEVTSADYPATSFEVPAGADNTVAARDILLPAPALVVESPPVEITVPAGQRRTATVTIRNNGALPGTWDAVREIEGGATAPQPDRPGAILRSWNPVASGVPHGYGIAELGGDVWISSRADRTLSRLTPDGVLLDTRPTADAIGDLAVIRDQGLLCYVVGGPAIRCIRPATGEVAYTVAGSGWSATTDGLAYLARTDMFFVSNARTIVQVKGSSHADAGTVVRQCGLSRYDQSLGIAGIGHVDTGSADGLVWIYPVSIGYGRVAHLSLVAPAGCGGRDLLPDPQPGGYTGAGLETDPAGNLWVFSNGPYEGPRVPKVSYIQSATPTYAELPWLAGGAPVVVGPGQSRAVEVTVDATSLRPGTYRATLELPTTAPKRPKLGIRVQVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J6</accession>
    <name>A0A7W7T2J6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="414"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="632" mass="68679" checksum="4A9F142F8B1F123F" modified="2021-06-02" version="1">MTDLWTRLAAVEARVRQAVEKKLAGDPSPDDPFRGLYLTPEAVRRVLDPRPDPDVLVPAEPGSRLSTVAERFRLDALDVELLLVVLMPDVDARFERLYGYLNDDVTRRRATVGLALELCGLPQAGTGRFRFDAGSRLVAGGLVEVREPDLPALSRPLRVPDRVVAHLLGHDPQPDLVRVVTGEPKSGFVRRVGDALRAGIGPIHLRGEGGAHVATSALACAGLDAVVLDVAALVDRDHPALDAVVREARLRGAGLVVGPVELLVPAKTRLLRELAAHDDLPLVLHGRQHWDPHWTDRPVVPVTVPPDDREPPDSALNGYRLGADETRHVVSVATGLAALDGRPVADEHLRAGVRARNGAGLDRLARRITPSVGPDDLVLPDATRRQLDELVLRARHRDRVLGSWRMRPGGGRGRGVVALFAGESGTGKTMSAEVVAAEIGVDLYVVDLSTVVDKYVGETEKNLERIFTEAAGVHGVLLFDEADAVFGKRSEVKDARDRYANVESAYLLQRMESLDGIAVLTTNLRSNVDEAFTRRIDVIADFPLPDRVQRLALWDRCLGTAMPRGDDLDLEFCAERFELAGGSIRSCAVTAAYLAAAADRPLAMADVISAVHQEYRKLGRLVLPNEFGPYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2S7</accession>
    <name>A0A7W7T2S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="22862" checksum="2FF5E7538A1BC038" modified="2021-06-02" version="1">MTEPIRLLLADDHPVVRAGLRAVLETEPDLVVVAEAATAEEAVDRAQRGDVDVVLLDLRFGKGMTGAEATAAITARPDAPRVLIVTTYDTDADTLPAIEAGATGYLLKDAPPEDLAAAVRTAAAGRTTLAPTVADRLLNRLRHPTTALTRRETEVLTLVAQGLSNQAVGTRLHLTEGTVKSHLARIYAKLGADSRTAAVATATDLGLIRRRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W9</accession>
    <name>A0A7W7T2W9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="9" type="ORF">F4559_001724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="7">
        <location>
            <begin position="94"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22534" checksum="D6BAFC3075FF7A78" modified="2021-06-02" version="1">MTSPSNRGAPASTEPRINDRIRVPEVRLVGPNGEQVGIVRIEDALRLAQEADLDLVEVAAQARPPVCKLMDYGKFKYESAQKARESRRNQQLTVIKEQKLRPKIDPHDYQTKKGHVARFLSHGNKVKVTIMFRGREQSRPELGYRLLQKLAEDVAELGFVESNPKQDGRNMIMVLAPHKTTKTRPVKQDQDDAAESVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3K1</accession>
    <name>A0A7W7T3K1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15397" checksum="8999147F4C18A78B" modified="2021-06-02" version="1">MTTARDIMTAGVQCVDQNESLLDAARMMRDLNVGSLPICGLDNRLHGIITDRDIVIRCIADGRDPAEMSAEELAGHLHWVNADDDVTDVLKTMEDNRIRRVPVIDDHRLVGMISEADLAQHLDEHQIAEFVEHIYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T401</accession>
    <name>A0A7W7T401_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5557" checksum="B7734EA8729B600F" modified="2021-06-02" version="1">MVFTVLELCVPQVVPVRVTSDVIPTGFGVVQRCLKWLPARASAAVWVSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T479</accession>
    <name>A0A7W7T479_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1099" mass="120363" checksum="32D06FA54D671F8F" modified="2021-06-02" version="1">MNDPDDFVEEFRRVLDRNPVPGGVQLTVALSLATRIEPELVRAVRVRVLPHLDVGAESDFWFGPWIGARRPHVVTLRQDLLSLLWETLRRWHGDRTYPHLGRLGEVVDRVHRDQSPAFRLEEEVRRLTYLDPGGAEAAGRVLRRATRAIADDGDPRFLGWLAGARRRLPAAALDTTDGWHLLLVAGGHRPEKFPDRPSVDGLKATGRVAEVLGPPTRVGPGRPPDLVGLGRQGDDLVIGGEAPVMLPLPAGIPPAVEVLIGDDVHGEWHSLDGPLPPGLGRERVRLRTVDGSVFEVPRRFGDSVRESPVLVRIEHTDGRPASYWLQPVRSASEHARSSDQPVGLLAKVLGEVAHDHAASARLVEWRDDHHANGMLVLYGRDENDRVRVAWQLAVDSERQGWAVYRGRQDPESAWWLTEDRQDCGAANVLLVVDRADSWQPRHLPLLRDGVRTSGRVRVLLLADDAGSWWQGVESLLSKTDCPGSGLRLADRAPTRPGPDLRDLVVRAITDLRRVDRTELVRRVAWLDSGTGLEVGAVAACLDVEAGSPVSTAPPGTVVLRHEHAYRRRLPVDPERPVSAEALAELVFLGCLMAPLARADARSLLLHRGVIDDDAGWFALLGEYGRRYLDDQEHLDPLGPVGLAEDLLAAVLLDGDKATGVDPEAARELVARLGDDHVPVRAAANALTVLSRAGKRWPRLLVDHVHPLARRRPESLVAAGGPALLAALRHADVDLLERLRRALPPATDRPVGLDVAVAELEERLVEHGFRQGRPGPHRDAPLHLRLAASRRLAGRLAGALDSARRAVEEYDRLVPVDLRRHTEPLCEALVLLSRLLGETGQPKEALERAEHADARLRRLISQSDATAPNSLIGRVLATLARERARQGDTPLAVDDARRAVEVLRELDELRPGAHRADLVDALSTLVDLSTEVDARGGMAYADEAVAMADELVAKNEWAHLHRIAAARLSRARFLDDREALDETESAVAEYRRVVSASPARFEGALGAALVRLARRQNAVEPQVALLTAQEAVGLCRKARFDGDRTTALIDALEQLAAVCRSNERRTDAIKAAAEAAGLLRGLGAVERAAELDARYRTPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T480</accession>
    <name>A0A7W7T480_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032721">
        <property type="entry name" value="Toxin-deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14424">
        <property type="entry name" value="Toxin-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="531" mass="55384" checksum="6CCAB222A0C482D7" modified="2021-06-02" version="1">MSNPLVVPRQDTTKPYTGLSPVEAAVALREAIANGDWIDRAIARTSLGLEGLAFLFDPVGSLAAWAVNWLIEQVKPLREGLDKLAGDPAQIRAYADTWKNISEAVTDAYQEYHREVAQGTASWTGSSGDAYRARTAQDVEQLKGAAVCADAISVVVRVAGELVGTVRELVRETVVQCLVTLFVRLPFWLLLEGVTLGLATPAVIANVGGLIAKFVRVIGTTLHRLAVSIARLRPLVARLGEIWEAIRKALAKRRGNNSAPGPGGRTVPPSEGATRPSGTTTPGADATPPGGRPVGDPTTPAGNPTPNGTTTPSGAPTSGTTTPSGAPGGSPTSPSGSPTAPSSAPGGTPPSPNSGGHGGGGDGTTPGGTQRISHPKLKSLDEIRDETAAVRRDLPQTARAKEKTVAAGQFVDENGVEQNLKAISGQNETLQRQGLEIPGGSKVPDEPRFEARNADGTISRPADAEAKILEDLSRRIDPDTKGTVRLWVDHPGGQGPCPSCVEVIKQFRARHPNVRVEVGWPHGGSMVLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y3</accession>
    <name>A0A7W7T4Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04793">
        <property type="entry name" value="LanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033889">
        <property type="entry name" value="LanC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="43193" checksum="A2CAAAEB64D54A73" modified="2021-06-02" version="1">MSAEANLRPDNGEVTLTRGEVTGQSLARGAVGTALLHVERARTGSGRWETAQAHIRRVVAGPVDAAEHAGLYYGAPAVAFLLHTVSDRHPRHYTASRTLDEHVLRLTRQRLAGVATRIDRGGSATFGEYDLFYGLTGIGALLLRHHPDSDELAGILRYAVTLAIRPCPEDDELPGWWVAHDPDEILPTPGGHANFGMAHGAAGLLSFLALATLNGTVVDDQHEAIAALTAWFDRWRQDGPDGPWWPQWITRGELRAGRPAHPHPGRPSWCYGTVGIARAQQLAALATDDPRRRQTAEDTLAAGLADTHLDRITEPGLCHGIAGIYQTTYRASRDALGPALAHRLPALAGRLARHAPSPDEVPEDDDAATGLLTGRTGTGLALETARHSTPPHTGWDTCLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z9</accession>
    <name>A0A7W7T4Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030596291" evidence="1">
        <location>
            <begin position="27"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="22575" checksum="6EE30542C63EAB13" modified="2021-06-02" version="1">MRRAGLLLAALLLTGCTTALPGTARPGPLPTPTPTFDLATTEKRVRAARLPDADMLGEGWQPEEVPFEGGGGYAIVPCPVPLSTEGAQSTAWTLHRWTRAEGTLAQHIVPYRRPGAGVETIEDARATLKCGTFRFAELTYTVLDEVKLPSLGADAQFAVCYDRDPWIMCTLLLVRADLLVSLTLYTTSEEKGATELERLGRVAAPLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C3</accession>
    <name>A0A7W7T5C3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="38738" checksum="593B2E99A8F70131" modified="2021-06-02" version="1">MSLLANTAPTACPGSASRTSPIAVDRHTMAPDRLLCYLQIKVHHLIQGHDWDTIHVVGGYDRRAVISAHEKTGKLFNFERPTAEAHGRHLIVKAFPGADYVHHYALIIATYLSMTGKPADTVTYELPDPTLSREAVAKLDLELDGDLVIVGWGLAHLAPADGAWTYGHGYAWQRAQIHGRRVVYLGFLHSIWGDVAGRVVTRLADLGAGDVVYVGKVGALNPDIEPNTRLATGNTSLVGGSLVAWPDFFGDFATAQPGVHTGIHVTSPSILLENRDWLTEHAEHAFVDPEIGPMGVAARDAGIDFGYLHVISNNLARHYPADLSNERHSDVVRRRTVLIRQIQDIVANRLAARPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P4</accession>
    <name>A0A7W7T5P4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="32" mass="3215" checksum="6BB2300472C254CC" modified="2021-06-02" version="1">MASFQVTVEMLVDVAALGSIAESGMCSVTVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U2</accession>
    <name>A0A7W7T5U2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="34362" checksum="3F80240BEE6A2389" modified="2021-06-02" version="1">MRATTLLDRRELVDVVRPVHPIASVYLGPDQGVPWSTRWPALVDRLRRAGASQATITDVEIAVPDAPDHAVAVFADGGHVPAVFSTPGRTGPDVAWFRAPAHVLPLVAYAQERPAHVLVIAGPDRARLRIVPGGLDADAVGVRMSCPTSDLAEACRTALAQSGARLLVVHGDLDTADRLRADLPGEATVRRVPGSRPVDVGDILRSTAWLWTARSLTDLAKPPHGGSVQGVARTIAALARGHVRELVVSPLERNAAAWFGGAPSQILPAEETTPTPWSRRRGDAVDVAVRAALLAGATVRVVGHRTPGAPAEGIGALCRFPLALVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T609</accession>
    <name>A0A7W7T609_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031155748" evidence="1">
        <location>
            <begin position="30"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="209"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="43206" checksum="117782D9B91B657E" modified="2021-06-02" version="1">MRKSVLSVLVAAALLGASATATAQPAAHAAGGWGATWGSSQHAGAELFGSPWVTEGFDDHSVRQVVRLSRGGPALRVRLSNAFGTSPLRLTGATVARTDKGASVRPGSVRHVTFQGRKSTTVAVGAELASDPIPFAVPSFEQVTVTLHFAGRTGPATAHGDATATSWRAKGDHRADVSASAFTESTTSWYYLSGVDVVDLSPRRDTVVAFGDSITDGAESTVDADRRYPDRLARRLGGRLGVVNAGISGNRVVNDSPCMGEKAPARFTRDVLSHPDVRTVILLEGINDIGFSEIDLGPCGLPNPRVTADEIIGGYRQIIAAAKAKGIRVVGGTLTPFKGAFYATDRGEGVRQAVNHWIRTSGAYDAVVDFDKAVADPADPTALRPEFDPGDHLHPNDAGYQAMADAVDLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T660</accession>
    <name>A0A7W7T660_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031014637" evidence="2">
        <location>
            <begin position="31"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23169" checksum="09C066F63DBA92AF" modified="2021-06-02" version="1">MSTPVPRPLRAALALLGLAVVIALAPAAVADPTAGTPGLAEIASTPTMWTPPSSSSTTPPPTSSSVPSSTMPPVPDENIARGGVAQASSTFPGYSAAKVNDGDTATTLGGDHSWANAEGRSPTTNPEWVFVRWSEQRSVGRIVVYTSDGYPLRDFDVQVLHESGGWWDTVRTYNYNTSSKVSLWFAPRKTVGVKILAKVGPSHQPIYTRVNEIQVFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C4</accession>
    <name>A0A7W7T6C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroimidazol reductase NimA-like FMN-containing flavoprotein (Pyridoxamine 5'-phosphate oxidase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14293" checksum="2284BA0CBE8A487F" modified="2021-06-02" version="1">MDREQCLGLLQTVRVGRLVFTEDALPAVQPVNFRLYRGQVVIRVAGGAKLAAATGNIVVAFQADELDPDLRTGWSVTVVGHANLITDVAELVDVAGTWLQPWVDGRRDHFIRVQTQKVTGRRLHAPLAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D2</accession>
    <name>A0A7W7T6D2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26636" checksum="4A61DB5AEF267D23" modified="2021-06-02" version="1">MPRARDSRPRHQQIAAELRDLIMRGELSPGTQLPSTAQLVERYGAANATIQHALKALKDEGFLDSRVGKGVYVRDRQPFVIDASAYIPPEPGRFRYQLLKVDNVVPPADIVAGLRLAPGATAIVRSRTLLHDDQPVELSASYYPAEIADNSSLAKPAKIRGGAPQALADLGFPQRTFVDRISARSPTVEEAETLDLPEGTPVIRQLRVIYSDNERPVEASVLIKGAHLYELLYHQTVETDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D9</accession>
    <name>A0A7W7T6D9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30308" checksum="F40DC1E14FD6B6E7" modified="2021-06-02" version="1">MSAPQDTTPLLVVEDLVVDYRISRKVNFRALKGVSIDVNAGECVGLVGESGSGKSTLGRALLGLAPVSGGKITFDGRDITHLKGAERRKLANDIQVVFQDPYGSLDPTMTVGEVLAEPLEVTGTKKAQAQAIVAEMLDRVKLPGDSVHRYPSEFSGGQRQRIAIARALVRRPRLIVCDEPVSALDLTTQATILDLFIDLQRETGVAYLFVSHDLGVVRRVCHRTSVMYQGEIVEAGPTEKITQQPEDPYTQRLLLAAPVADPTRQAERRAAWLGLRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6E6</accession>
    <name>A0A7W7T6E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="14120" checksum="FA81FACD563DF9C7" modified="2021-06-02" version="1">MTRGYQATEEEIHSVLDWFGRWDALAVAKDVEALADLSYFPVNAVTDGSARIWDRERFLVEMGKALAGSGTMESERTPVFVNANLVVVFTDAVFTFGDDSVETRYADILIKVDGDWRFQTMAQGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L4</accession>
    <name>A0A7W7T6L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (DUF2252 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="49715" checksum="B326CA2B87A0BC34" modified="2021-06-02" version="1">MGERKRAEAAAALGRWTEPEEVLAQGRALRSQVDHAAHRAMSLAADRPSVVDYVEASNEGRLPDLVPLRIGRMLASPFSFFRGSAGLMAGDLAAGVASGLDAQLCGDAHAANFGLYGTPEGTIVMDINDFDETFPGPWEWDLKRLATSLVLAGREGGVSEKGCRDAAEDAVHAYREAAVHLAGLPFLESWSALGDESVLSKSKAQDLTDEFSKAASKARKNTSAKVAAKWTRREGEHWRFVADPPVLTRIPDETARGVVDALPSYVDTLRESRYNLIMRYGVSDVAFRVVGTGSVGLRNYLVLLHGNGDEALVLQVKEARPSALAPFLGTSEHKHEGKRIVHGARLVQAESDILLGWTTIEDRHFIVRQFRNRKGEIDATTLKRDDLDDYGRLAGALLARAHSRSVDPRLLAGYCADGEDLDTAIGRYALDYADRTEADHAELAKAVKDGRLPAHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W5</accession>
    <name>A0A7W7T6W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="28744" checksum="1107522C9E2D04BC" modified="2021-06-02" version="1">MRAQIDRRTLRTDRWWLPPLVTAVGLLLISIYAAARTFMGEYYWVDEYHYLTPMYSPCLSQECLPAAAHFGRPLPELPGFLTPPVVILPFLLGFRVTCYYYRKAYYRAAWLSPPACAVAEPHAKYTGETRFPLIAQNLHRYFFYAASILLLINVYDAFYALGTGLGLGNIVLLVNVGLLGAYTLSCHSCRHIAGGRLKHFSKHPIRYRMWTFVSKLNARHMQLAWASLIFVCLTDLYVALVASGTIADPRIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T719</accession>
    <name>A0A7W7T719_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18049" checksum="814C7ABC680CD72E" modified="2021-06-02" version="1">MGLLDALRRRLARGAVPTLAIDSPGLRVVVTAFDLVEADSAVLARSPEWDPAADAVLRHHLELPADQVQRARELLAPDGWELREGSPAYALRVQKLDVLGCARERSRMAGLAQRLGGDWIGWDALQVCRGNADNIVATWHPTRRRTADERATDQDPGVQPPPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T751</accession>
    <name>A0A7W7T751_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">F4559_005150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="110" mass="11486" checksum="50B1F7231F3DD66D" modified="2021-06-02" version="1">MIPLLVFAGAAVGTPVRYLVGRLLNRRFPAGTLAVNVVGSFLLGCLTAVPPAWYALLGTGFCGGLTTYSTFGMETVALLETRDHRRAALSVGLNLALAITAATLGHVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7J1</accession>
    <name>A0A7W7T7J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G3E family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="367" mass="39712" checksum="A8AAC037907DF301" modified="2021-06-02" version="1">MIRFIALSGFLGAGKTTTMLAVARRLEAAGRRVAVVTNDQSDDLVDTKLARGALGAVGEVTGGCFCCRFEDLVDVVREIVEEHRPDTIIAESVGSCTDLQATVIRPLRRYYGNTFAVAPLTAVADPLRFRAFARVWERGEPDTDMTYLYRRQLDDAEVIVVGKADVVPAAHLDVTEAAVREHFPHARVLVCSALTGLGLDRLVAEWSVDAAEGRDLEVDYDRYAAAEAALAWQNRTFDVEAAGDVLPVDWGRSVLRRIGEECAVRDWLVGHAKASLESSSGLTKLGITGTGVEPVVDVETPDPVRTFRVVLNARIACEPEELDRLVAEAVGAADERFGTGSRGAPASAFKPGYPRPLHRLAAEVGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L3</accession>
    <name>A0A7W7T7L3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemoglobin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019795">
        <property type="entry name" value="Globin_bac-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001486">
        <property type="entry name" value="Hemoglobin_trunc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01152">
        <property type="entry name" value="Bac_globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01213">
        <property type="entry name" value="GLOBIN_FAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14956" checksum="C10EED8CDE88CF3A" modified="2021-06-02" version="1">MTSPENFYEAVGGYETFHRIVARFYEEVADDAILRPLYPEEDLGPAEERFRLFLMQYWGGPHTYSEQRGHPRLRMRHAPFVIGPVERDAWLRCMRVAVDSVDLTPEHRDQLWAYLEMAAHSLMNAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L4</accession>
    <name>A0A7W7T7L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8448" checksum="07F54BDCB0FB366A" modified="2021-06-02" version="1">MTVRLRVHVFDRMARAAGFRSDFQVAAAMGVNRSTVKRVKDGKLRPGPAFIGGALTALAPKKFEELFQVVDQERTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7M6</accession>
    <name>A0A7W7T7M6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014550">
        <property type="entry name" value="UCP028704_OpgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10129">
        <property type="entry name" value="OpgC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="72"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18130" checksum="1DD1485B5AC54122" modified="2021-06-02" version="1">MSTQPRLRAPRNRVSRRSITLWTLHAVIGWVVLLVPQAVVWIFTRTTWQLGFVIGTLVVGIAHTLVMPRWRYRVHRWETTAEAVYTLAGWFTQEWRVAPISRIQTVDSKRGPLQQLLGLSTVTVTTASAAGPVHIEGLDHEDAVRLVDELTATTQATPGDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X1</accession>
    <name>A0A7W7T7X1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10795" checksum="B1C837221087E61E" modified="2021-06-02" version="1">MDALIAEATVDCYNDSECVTAFHTMIEEYLAVPFRTVVLGVDVIVTGVDLTDDEQIVAVCVRGRSKQRIPVLELPLPDTPVEGAQWIDAYRRWARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T822</accession>
    <name>A0A7W7T822_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rv2175c_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041098">
        <property type="entry name" value="Rv2175c_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18367">
        <property type="entry name" value="Rv2175c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rv2175c_C" evidence="1">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13071" checksum="B78CDF278299BE43" modified="2021-06-02" version="1">MSAIPAAADVLAPDVEVLDLPEVAERLSLPVTRVHQLLRDGQLLAERRNGVLVVPADFLAAGGVVKGLPGTITVLRDSGYSTEEILRWLFTDDDTLPGTPIEALRGDRGREVKRRAQAMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T837</accession>
    <name>A0A7W7T837_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Starch synthase</fullName>
            <ecNumber evidence="5">2.4.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="191"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="384" mass="41450" checksum="5E0E05E0D695389B" modified="2021-06-02" version="1">MRIGLLTREYPPEVYGGAGVHVGFLVPRLRELVDVDVHAFGTPRADARGYHPAHGLENANAALATLSVDLEMAAALADVRLVHSHTWYANMAGHLAKLLHGVPHVVTAHSLEPRRPWKAEQLGGGYRVSSWVERTAYEAADAVIAVSEGMRTDVLDCYPALDPARVHVVRNGIDPDAYRPVDETDALVARGIDPTRPIVAFVGRITRQKGVGHLVAAAHRFSADAQLVLCAGAPDTPELAEETRAAVAELSAVRPGVFWIRQMLQPAEVRQIMSHATVFVCPSVYEPLGIVNLEAMACGTAVVASDVGGIPEVVEHGVTGLLVHYDERDVEAFRQGLADAVDAVLASPSRAREFGAAGRERAVREFSWTTVAERTVEVYDLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T863</accession>
    <name>A0A7W7T863_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="28589" checksum="B1FBBF90E54525DF" modified="2021-06-02" version="1">MLRSLFAGISGLRTHQRMTDVTGNNIANVNTTGFKGSQVIFQDALSQTIRGAATEGATTAATNPAQVGLGVELAGVNTNFGQGATQVTGRDTDMLIQGDGFFVVDAVGQRSYTRNGALSFDSHGSLTTTEGYLIQGWSADPVTGAIDTTGATGRLTIPSSTYADFSVAPDGTITGVLPDGTTKKIGAIAVANFANPDGLEKVGGSLYRASVNSGTEQIGLGGQNGTGTFVTGALEMSNVDLAQELTNLIIAQRGFQANSKVISTSDELLQDLMNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J3</accession>
    <name>A0A7W7T8J3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DivIVA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="19336" checksum="0D2D5F8A300DDC5B" modified="2021-06-02" version="1">MPFPYLTPARIRSLRFSRRRNGKGYDPAQVDAAVIRIADGLAGLVRLEPDEVRNLRFHEVPGGYDQRPVDEFLGQVEWQLRAGVVPPTRLRSGQDLLDVRLPRASGGYDRGEVDAFLARAATSLDGRGRMTAVEVRHTRFSTTTGLRRGYRVQAVDALLDDLEQEFRFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y3</accession>
    <name>A0A7W7T8Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase (Nitroreductase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14935" checksum="4EADF8D2186AE108" modified="2021-06-02" version="1">MNDHIRRYVETDGAEGHEWRPGVHTLLLTTKGRKSGEPRRTALIYRRHGDAVVVVASSGGAPKHPAWYLNLETNSEAEVQVGPEKYQVRARTAEGEERAELWKSLNEVWPDYANYQTKTDREIPVVVLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z4</accession>
    <name>A0A7W7T8Z4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="90"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="271"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="49178" checksum="E76C3BFADDF6C876" modified="2021-06-02" version="1">MILPRPVSFGRGDGEVVFDGVVDVRQWGGPAEGYRLTIAPSGVVIEAADAAGEAHARQTLRQLSGPSAFRAVAPGPVTLPVCVVEDHPRFRWRGCMLDVARHFLPKPDLLRYVDLLAVHKLNVLHLHLTDDQGWRFESLRFPLLHEVGGWRPSSRYGDRRHGGQTGRPHGGYYTQDDLREVVAYAAERHITVVPEIDVPGHSQAAIAAYPELGVAPGGVWTDWGINPNLLNTAPSTVDFVLAVFEELLDVFPGEYVGFGGDEAEGGDGSLVRAVTEFLVSRGRRPFGWDEALETGPLPDATVIASWRGEDAGVTALDRGLDVVMCPEKYVYLDYRQSDSADEPVPVGTVTTLEDVYGYEPAAADRLLGVQANVWTEHLDSPRRLDYATFPRLCALAELAWSTGERDVAEFRDRLAGSHLPRLAALGVEYRPLSGPLPWQRLPGVPGHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A7</accession>
    <name>A0A7W7T9A7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase-like metal-dependent hydrolase (Beta-lactamase superfamily II)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="BLACT_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26659" checksum="B2EDA269CD8806B5" modified="2021-06-02" version="1">MSYGVLRQVTDSAGVLLAENPGVMTLDGTNTWVLRAPGAESAVVVDPGPPGTHLDRLEALGPVELVLLTHGHPDHSEGAVEFGRRVDAPVRAVDPTFRTGTGLDHDEVIKAGGLDLTVLRTPGHTSDSVCFVLADAVLTGDTVLGRGTTIVAHPDGRLGDYLASLRLLAGLPPGRLVLPGHGPVLPDVVAAAAGYLAHRGQRLDQVRAAVAELGGTPTPRQVVELVYRDVDQSLWPAAEWSVRAQLEYLREAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A8</accession>
    <name>A0A7W7T9A8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="22773" checksum="8F71C7A072405D3B" modified="2021-06-02" version="1">MTDVPDWMRGLALAVDGLDHRAFTRISPPPAGVITRPAAVLMLLGEGADGPDVLLLRRADTLGSHPGQVAFPGGKVDPTDDGPADTALREAFEETGVLRAGVTVVATLPELFVPVSMFVVTPVLAYWHRPAPVVAVDANETAAVARVPLAHLADPANRFRVRHPSGYVGPAFSAPGMLVWGFTAGLLGRLLSLGGWERPWDPDDVRDLEPASRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y5</accession>
    <name>A0A7W7T9Y5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="5"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26180" checksum="AB107176E1C99779" modified="2021-06-02" version="1">MRLLVLGDSLTFHGPDGPLPADDPRLWPNVAAARLGGRAELAAGIGWTARDAWWSLTGDPRVWSWLPGVDVLVLAVGHMDTLPSPLPTYLRQGVRHLRPDAVRRWVRKAYQAAQPVMSRWTPWVALPPSSTVRYLDSCVRAVRALKPGMRVVGMTPSVHCAPSYGFVHTGRPAGERAVRAWASGADVPLLDLPAVVGDHVRSRRGNPDGMHWGWEGHELVGTRMADLIGSVAVGHSTSSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBA1</accession>
    <name>A0A7W7TBA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="24001" checksum="5986C887DB849A28" modified="2021-06-02" version="1">MNSGRPGIALVDPVPLFREGLQAVVRRTPGLHWLGATGQLHTAVRLHERLHPDVMLVDSVLDPQGHLATLLTETDPRLAVVSLVREPHRTAKYVRAALAAGVRGLVPRDGEIVEVIQAIMRSFHERIHLDPTLAPLAAGFTPTVEAGTRRSLSRREYEVLQLIADGLENQAVATELYVSVETVRTHVKNILRKLRARDRTHAVSLAYQSGLLTGNLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT01</accession>
    <name>A0A7W7WT01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease-3</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09086">
        <property type="entry name" value="ExoIII-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="29986" checksum="2E722B1B067EDAAD" modified="2021-06-02" version="1">MRLATWNVNSVRQRAARLLPWLDERRPDVVCLQETKLADDAFDTLLGEELADRGYAVARHGEPRWNGVALLSRVGLENTVYGLPDGPGFPHAEARAVSATCAGIRVHCVYVPNGREVDSDHYRYKLAWLDALRNSLDDGNTVVAGDLNIAPTDADLFDPARFVDSTHVTPAERDALHALGLVDVVRERWPEERVFSYWDYRAGMFHQDLGMRIDLVLATADVAARTAAAWVDRKARKGAGPSDHAPVIVDLDTAPDGDIGPVVPPPSAPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT24</accession>
    <name>A0A7W7WT24_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="4"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="39702" checksum="079776A77B895ABA" modified="2021-06-02" version="1">MANRWVVLAVGTVAQGVNAAVFLGLPALTPQLREHFGLTLPQVGLLLGAVNLGTMVALVPWGVVADRHGERLAMTIGGFGAALFLALTAVGGPVLAGVALVGVGLCGASVNAASGRAVMNWFTTDKRGLAMGVRQAASPLGAALTAAVLPGVAIGAGVPVAFVALAGVTGFVALATAALVREPPGAVRATRAPGLVLADPRLIRLSVASGLLVVPQFTAATLMVVLLVERVGVPVGPAAGLFAAAQVLGGLGRLAVGVWSDAVRDRIGPLRKLAVACAVAFGLCTAAVDAPTWVVCAVFVATTAIAVSWNGVALTAAGELAPPGRSGTAIAMQNGANYLAATVTPPLAAWVADTFGWAVALLLAAVTAIGARLLLGRASTAGQGPPRRTSRSRHARKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTG6</accession>
    <name>A0A7W7WTG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.289</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.289" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102096">
        <property type="term" value="F:decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30721" checksum="C795F95A119C195A" modified="2021-06-02" version="1">MTRYGDDLAVVTVTYSPGGTLDRFLETLADATTRPVRVVLADNGSADGVPERAAEAHDHVTFLPTGGNLGYGAAANHGVASLPDDVGWVVVANPDLEWGAGSLDALLAATKRWPRGGAFGPLIREPDGEVYPSARLLPSIGRGVGHAAFGKIWPGNPWTREYRQEQAAVRERTAGWLSGSCLLLRREAFDSVDGFDPRYFMYFEDVDLGDRLVKAGWLNVYAPEAQVVHIGGVSTAKSSQRMLAAHHSSAYRYLADRHRGLVHAPLLLAVRAGLALRLKLVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM8</accession>
    <name>A0A7W7WTM8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="32063" checksum="BE2E210A5978EE3F" modified="2021-06-02" version="1">MLRPFVAYLRVYEPLSALDAPLAEQARKALEAGALSRADVGARERELWLRSQLARPRRLLPGERADGAVAPDAPFDVLALDPADVPGDVGEGPLVCPLDLRARSAAALVGFLATSTAPLREAALSVEPDEVRARATAVMAELNRGAVHVISTTWTVPLPWFALVEQDARRIVLTPKNDPDREVSWRVSMGEARARVARAHRVVSQSLGNDGPAKVLSDTGRWLDHFAPDSAVELDYGGLVQLIDDKDLQEDTSAEDVNAIVDAFESGDVEEVALRYERLREFWGEPARRERHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ4</accession>
    <name>A0A7W7WTZ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030808400" evidence="2">
        <location>
            <begin position="32"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23728" checksum="BFFADDBCE4461BC0" modified="2021-06-02" version="1">MTTILPSSTSTAFRATVGAIFAHHLAATAHAVEIGCTDGDREGRHVDPAGPYPLPSTSTLDSVPRLPGVRLDDGEADSRMRVLLASLEETVQCVRHDVQVRAQDVANRYHHDQDAHAFRIDVEELKAFAKAGVDQALERWFASVSDLGDRFPLARDRVLVTTQRVGGLVTAFVIGFVNFATDLANTVPDRGARAYEKVTDYFETVSSGLRHAFRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU27</accession>
    <name>A0A7W7WU27_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31520" checksum="DF8001F98567CC24" modified="2021-06-02" version="1">MTTTLTIPFTATLVAPLHHGAGTAGNTSLIRTQRMVRPDGTVAQVPFVSGNSLRHGLRAGLAWHAVRTLGVEDGGLSKAVVDLLWSGGAITRTGSQTDLALLRRVEHLYPPLALMGYSAAADMTAGTLAVDQLHLVCAENAWRLPGRLAGDPRAARPASAFRGEEFGTRHDVAGTPVDRYTALADELVPTTTQMIYEHQVVLPGAALYGGLVLTPAATDAQLRVLLVALDEIMPADRDGVRVLQLAAKRGVGYGTCRVDLDLPDGLPTPADARAWWEAHLVEHAEEITALWQEIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU58</accession>
    <name>A0A7W7WU58_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="6752" checksum="C0BD50D6F2F96901" modified="2021-06-02" version="1">MSEQATVSSHHADGSATVLRDDGVLVDVPATAVTEGGWRFLRPGQRVLVVRSADGAVRALLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK8</accession>
    <name>A0A7W7WUK8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="29689" checksum="1CF24D36C014D0CE" modified="2021-06-02" version="1">MGTEQRRVLRLLTEADEQHPDAWLLLRSLAGQDPTWNDGEPTKADMSRWNSARRAVRTLVERGLAEKRTTDYAGTKMAVVRLRREGRGTTPLPWSVEDRLFAHLKLMDDVQNDLLRYFGSRYRKATVSRPPMESAVVFDPDDPGQGYRAVHLDPTQSSDGDWLRRYADLVATADRDSQGAIEKEVQRRVEVELARHSRAGHGGCTSAPEPGQPAQRAADTLSDTELLWEIAELTSLELRDILVDATKDLYRRTRQDTRPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR6</accession>
    <name>A0A7W7WUR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9444" checksum="CBE442FA92E78B9D" modified="2021-06-02" version="1">MAIGVAMVNGDSSRARHIAQVWSAVAILCLPFGWAVDVSLPVDYWAGVFAGAYGILASPLVALAVALVWWPVRALAASARNPRRPRSAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY3</accession>
    <name>A0A7W7WUY3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="29980" checksum="107D7A5E7D4E1AF6" modified="2021-06-02" version="1">MLVELAIGDAYGAGFEYADPEFTATYNTLAGYVQHPTHLGVRPGAYTDDTQLSLALAELLVSGDEWSPKVIAERFVEVFRRDPREGYARGFQLFLEKIESGSEFLERIRPDSDKSGAAMRSGPLGLLHSVTDVVRHAEIQARVTHDTPDGIAAARAAALAVHYCHHDLGPVADVGAWVARTLDEPRWAVPWTGKVGSKGVMSVRAALTALASHTRASEVLRACVAFTGDVDTVATIALAAASRSGWVEADLPEVLYTDLENGEYGRDYLARLDSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY5</accession>
    <name>A0A7W7WUY5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24460" checksum="663A2FE166CC9DDD" modified="2021-06-02" version="1">MLERHALIIGASRGLGLHLAGELARRGWAVVATTRGGADDGLRAGPGLTVEHLDMTVPAQVTALRDRLADRRLDLLFVNAAIDRGDVPIHEVPTAVFTEVMITNALSPLRVLEALRDLVRPDGTVAVMSSEQGSVSLNTEGGYELYKASKAALNQLVRGYATRHAADGHTTLLVDPGHNRTRLGGPDAPLDPHDTVPAIADLLEAHTTPTPTPAPHLHFLDRHGTPVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV61</accession>
    <name>A0A7W7WV61_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="36836" checksum="B52EE9AAAFB0355E" modified="2021-06-02" version="1">MRPRLAVLYAGGVLGPFGGAMTSSVLPELGRDFAVDPGTAAVSVTAYLVPFAALLLVSGTYGMRWGARRTVLVAYVLYALASVLCAVAWAFPVFLAGRAAQGVANAFTTPLLLATIASVTPAARLGRALGLFASLQSLGQTSAPLVGGLSAEVSWRLAFVGAAVVATVLAVAGLPADPARGERPRLRSAWAPPTPRLAMVGFVAWCCVGGLSFLVALRLGDVFGIGASQRGLVLTGFGVAGIVAARSTGRLVERWGATRCVLVGALAGGLLIAGAGALPGVLAVAGAWALAGAVSQVVVVGLNAAVLGGVGDNRGGAVSVVQSLRFVGGAVAPVAFVPLYAVAPSIAFLVPAALVMTAVPTLLAGHPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD1</accession>
    <name>A0A7W7WVD1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="366"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="577" mass="61875" checksum="38892E3BE7ADFDFB" modified="2021-06-02" version="1">MRDHQSDPFDVAAAVRVVTRAGRTARTAAVEVLMSVPGVRSARVAGEKPWLGDVVVPLELGGALVVTSDEVDGRLETLVDAVAAALDAVRFPSDGETLRDAVIAEMPAMVCLFDPEGLLSWSNLVRWPDGTPLHYGESRLDAIATQVHPDDQADVTRLMGELAPGDTARFSARVRKDNGGWQVLDITLLERTNDPVIHGMVAFANDVTALHEAEDRVRATVTRLSSLVEALDVGVLVQDAEGRLLVSNTALGAIAGLSGAPEDMVGMARDELRTLRTRPEADYARLDQLSQRCMQDRIPVHGVVVPLGDDRALELDFLPIGLDDRGLGQMWVLRDITEQVGLRQALERRNAELSRLSSLKTEFLSVVSHELRTPLTALTSLTPVLVADQPDGIRVVAEAVERNVTRMATLVETLLFLAGVESHSLEMATIDADADVLVRMEVDALRALAATSSVTLELEPAPERTLVHADPALFSRMVHHVVAAGIGSSPAGGRVKVRTSARRPGVWAVEVTDQVPLTVQAGRLFTTVPRGNRSPDPLIGSGLGLALARAIAERHGGAIYLEPSPEGGTTVRVELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK1</accession>
    <name>A0A7W7WVK1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011748">
        <property type="entry name" value="Unchr_phage_tail-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02242">
        <property type="entry name" value="tail_TIGR02242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18293" checksum="6D9FD9C1653FD434" modified="2021-06-02" version="1">MRAALPSLPSTHPIGAMLPSLYAADDFASRFTSGLDAVLSAILSTLDCIAAYVDPVLAPEDFVEWLASWVAADPDPAWPLDRRREVVRRTVDLHRRRGTARGLADRLALAPGVRAEVVDGAGTRWSSTPDTPLPDAADVVVRVYEGDRAAVEALVAPVCPVHVRCVVETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW55</accession>
    <name>A0A7W7WW55_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="128"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="25006" checksum="15DF304DEB463879" modified="2021-06-02" version="1">MSTVLVVEDEPDIALALRLNLEAEGHEVLVAEDGKTGLRRLHDAKPALVLLDIGLPVMDGWMVLERIRDVSDVPVLLLTAHGMEADKVRGLRGGADDYLTKPFSAKELLARIDAILRRAESAGGGDKGDVYDDGVVRLDHRARRVFVNGAEVEVNATEYKLLAVFVQHRGAVLSPVQLMDKVWNDPTGIGAEKVKFAVMRLRRKLGWSADDSPIRAARGMGYRYDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW58</accession>
    <name>A0A7W7WW58_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="123"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="24665" checksum="BE1567E3DD4BA3FF" modified="2021-06-02" version="1">MTALRLPGHVHAAATARGGGVLLDRNSGRCYALNATAFALLSEWDRSGDFAAGLRRVAARDPAYRGERFARDSRTLADRLVAAGLLTSSPVPEAPVPEAAFEPSDAGESGRFAAVAVLVASVLVRLPFRVTAAVLEFSRRHWCRAGATREQVLAVILSADAGTRLHPGRVACLELSLGAVLALALRRRYAALVIGAAGDPCRFHAWVRAQDGPLNYPPETDLDDFRPVFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG2</accession>
    <name>A0A7W7WWG2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12225" checksum="FD55CE5E613E6C5A" modified="2021-06-02" version="1">MAGEVDAHTASRLRDHLVERIRPGGPDLVVDLGGVRFLAAAGLGVLAEVAASADAAGVRIHVVARTRPVLLPLSLTGLDVVLDVHRYLGDVPLRGGMSDRMPRRSPVMSVRSGSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG4</accession>
    <name>A0A7W7WWG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease BN (tRNA processing enzyme)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="24581" checksum="B54EDE6E2AD5F87B" modified="2021-06-02" version="1">MTFGVTVLGTATPHPRPDRPCSGYLLHTAATRIWVDAGTGTLAELQRHTALADVDAIWISHTHADHAADLLPAYYALLFAGLPPHRPTLLGPPGLAHRLETFLASTGPNPADAAFDVRELHDGARFDVGDLSLRTAAVDHGVPAFGLRAAHDGRVFAYSGDTAPCPALDALADGADLFLCEADGGGPDHCAPEDAARAGRGAGGLLITHVGPGLTEAEAAERAAAPVARTGVTYPIGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWI8</accession>
    <name>A0A7W7WWI8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cofactor-binding repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022444">
        <property type="entry name" value="Cofactor-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03807">
        <property type="entry name" value="RR_fam_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="311"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="550" mass="58416" checksum="2F042198F0ECCD91" modified="2021-06-02" version="1">MTDFHVSPTGDDANPGDAGRPFATLHRAVEAAGTITGQVVVHLVPGTHFLAEPLVFGENSGPIRIEGRDAVLSGGRVVDAWRERDGVWSADVGGLDTRHLAADGRRVERAAIPGIPGTASANDTGYVTDAVLDWRPGVEFVFRGVYPWTEARCPVAEVVRDGDTTRITMARPAFDRAKELYNATWYGNTLSGPGLPTGVENDPSFLTPDTFALDRSRPGHHVLHYFPLPGETPHVVAAALETLVHAVGARDLSFHGVTFADSTWLYPVGDNGFLHYHGNGHYVDGPIETVVLAEDEAWLTVPGRSRQIPAAVLVEDGTGVVFEDCRFTRLGATALGATGGTGLEVRRCRFDALAASAVALTGTRDAVVTDNVVRGTGLDHSGSPGVALLDTTDCTIAHNEITDVPHCGIVVGPGRGTRVLRNHVADSMGVLADGGGIYLSGPQGDSHDDGAVIQGNVIENTRTPYNFALYTDYGAAWVTVADNVVFRADNSATLTPSPPLREVVYRDNFWHKEPSGAVPEGVTYTGNVVLSDEAELLAATVDLRTRAGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ0</accession>
    <name>A0A7W7WWJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YbjT (DUF2867 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="25938" checksum="0F7243D7E6F8AC33" modified="2021-06-02" version="1">MRIAVAGATGNIGRLTAAVLERDGHEVVRISRSLGVDLLTGEGLDDALTGVDAVLDATNAPAGDRESVVSYFGAATANLLAAEERAGVRHHVLLSIVGIAGVPGNAHYAGKREQERLIEAGGVPWTIVPVTQFHDFAEMVSGWFEQDGVVTVAPLLVQPIAPADVADVLAGIVTGTPLGRHRDVAGPETQDLIDMARRTLAARGREVKFVPTWSATYGLDMSGNALLPGPDAHLAPTTFDSWLADRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK4</accession>
    <name>A0A7W7WWK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13404" checksum="4B5233067D5A6269" modified="2021-06-02" version="1">MDALVRDRYRMTLSTAGEPVPVRTPPEKEFTDGERVDHLLKVRVGRQRWTTQFYSASLIDFQGDPEELRTTSDLDDLREFGRLLHRSTGRRTVLVPETLDPESVEPYLEFGRPGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX89</accession>
    <name>A0A7W7WX89_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003874">
        <property type="term" value="F:6-pyruvoyltetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17385" checksum="71EA33BA4B55E3C8" modified="2021-06-02" version="1">MTHKIVVAVSFESGHRLPHLTGKCVSLHGHSWSAEVTVGASELSPAATVVEFGDLKAGLRRWIDDHLDHATMLGTDDPLITPLTIAGSRVFRFGADDPEDDAEAFASGLPWPTVEAVTVLLGRVAENVLSRISHIDGARVERVLVRETRLNSAIHEPSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG6</accession>
    <name>A0A7W7WXG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="12248" checksum="1C88E9A4E20F1DF0" modified="2021-06-02" version="1">MTWPAKLIGLATAAYGAAVVVRPEVLTKPTGLATRPTPAISALVRSVGTRDVVSGLSVALAPEGTPTRAALAVRIAMDLGDAAVLGAAAPTAAVRRKVLAVTLGWAALNLVVLWKSPSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN3</accession>
    <name>A0A7W7WXN3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="5">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe(III)-[cytochrome c] + H2O + nitric oxide = Fe(II)-[cytochrome c] + 2 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="627"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="866" mass="90878" checksum="B4D8C83E8AED3FB1" modified="2021-06-02" version="1">MTQFVDLIPPPARGRRSGPRGSVFVWANIVVLGWLALAVALLAVHDVLGLPVWVALHALLLGAVTNAIVIWSEHFVVTLCRVPGPPPRRLALGLTVLNLFITAALIGVAADATVVAGAGGAGVAVIATVHTIALFRMTRTALPGRFGYLVGYYTAASAALVLGALSGAALAIGAAQWYVRLWTAHVHLTLLGWVGLSVLGTLFTLWPTTTGTRITDSTLTAARRALPTLAAGLLAAVAGMLTATVWVTVAGLLCYTAGIVLTIIPLRPATTPHGPAAWMLAAATAWLGISVLLDAVRLLVAGSVEDLPGVVTTVMPVLAVGFAAQVLVGALTKLLPVVLGRGPAEHRAIADILARGWQLRLIAANLAVPLVAVGLPSPLPQLGWALAALSVATFLVLALRVAIPVARRGAFPLEPAQKQAHGTTSGVLAGLIAVALAVAVAGSGQDTTATAPVSAPTHTVEVTLTGMRVHPDTVDVPAGTRLVLRVTNQEAMPHDLRLDTGQHTPRLHHGETALLDVGPVGETRHAWCTVAGHRAAGMTMTIRTPSDHQHTTPDSHSDDNGNNSDTAPTAGLDLAADPTPGWVPRDATLAPTTATLHRIELRATEQDLEVAPGRRERRWTFADTSPGTVPGPTLHGRVGDQFEITLINDTTIGHGMDFHASALAPDGPMRTIGPGERLVYRFTATRAGAWLYHCSTMPMSQHIANGMYGAVIIDPPDLPAVDHEYLMVSSQLYLGAPGSDNQVRKIQAGQPDGWMFNGMAAQYDHAPLTAHPGQRIRIWLVNAGPGDSTAFHVVGAQFDTVYKEGARLLRPSETAGGAQVLDLAPAQGGFVELTFPEPGHYPFVDHDMRHAENGAHGLFTVTEQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW5</accession>
    <name>A0A7W7WXW5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="PTHR40630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="12362" checksum="64EA1DAABA10BE6B" modified="2021-06-02" version="1">MTDSLWDEFHRVVNMTSHELEDWLRTRSAGESGEELPDRAGTPTGQEVLRVLRKRRTDLTTEDVKVMRKVVDRVHAQRREDLEPTAGEAHWRHRLMSIGHDPLKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX3</accession>
    <name>A0A7W7WXX3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative intracellular protease/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22541" checksum="4BB0284707FD6288" modified="2021-06-02" version="1">MTTTKTVHVALYDTLSDWEFGFATARLNLPHFQKRPGVFQVRTVAATLDPITTMGGLRILPDTTLDRITPDDSALLLLSGSDTWTTGANREFSAAARRWLDAGVPVAAICGATIGLADEGLLDDRPHTGNAVEELSSVPNYRGQAHFRQERAVRHDKLITAGGASALEFAREILAELDVYEPAVLEAWYGLFSTGNPEWFGKLVAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ0</accession>
    <name>A0A7W7WXZ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner membrane transporter RhtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="173"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="31933" checksum="0B55CC6EA7917AAA" modified="2021-06-02" version="1">MSGAAMMVPVVMATAHGTPRRRHPAGGPPALASRAFRAIPPPALVLLGVITVQVGAAVAKRLFAVAGPGGAVTLRLVFAALILVLIWRPSLRLDPRTYAVVAGYGLVLGAMNLTFYHAIEHIPLGAAVTIEFLGPLAVAVLGSRRWLDGLWALLAAAGVVLLTRAEGGLSLVGVGFALAAAVCWAGYILLAAKLGDRTSDGRGLALAMVFGALLALPFGVGQAGAAMLQPSVLIAGVAVALLSSVIPYSLELEALRKIPPRVFGILMSLEPAVAALAGLVVLHEALRPTQWIAVCCVVLASVGATRSARPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY08</accession>
    <name>A0A7W7WY08_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030518436" evidence="1">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="16931" checksum="F3F959DD6E2BC7C4" modified="2021-06-02" version="1">MRVTARLSTVLLATAGLVAAGLGLGSASAQDDVRFLTFADKCVDVSGASGGDGANIIQWSCHGGANQDFSIVNAGNGQVEIRTFAGKCVDVSGVSSSNGAKIIQWRCHGGANQKFRIEDQGDGRVVIRTFAGKCVDVSGASSSDGAQIIQWQCHGGANQKFRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY92</accession>
    <name>A0A7W7WY92_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="41923" checksum="A0329A6C70BF39F4" modified="2021-06-02" version="1">MPGKDASEPRLPGEVWVLVAASFIIAVGFGIVAPVLPSYAKSFDVGTTAVSAVVSAFALVRLLFAPMSGRLVSRIGEPRTYVAGILIVAAGTAACGFATAYWQLLVFRSLAGIGSTMFTVSAVGLLIRITPPSMRGRASGLWATGFLLGNIAGPIVGAALVGFSIRVPFVVYAVTLVLAAFVVWWFLRRSTLAAVSPDAAPTLTVRQAWNSGAFRAALVSSFANGWAVFGVRISLVPLFVVEALHGSPGLAGISLSVFAVGNAAVLMVSGRLSDTIGRKPLAIAGLVVSAVGTIWLGFTESVPAFMIASAVAGIGAGLLNPPQNAVVADVIGPDAKGGPVLAAFQMVADCGAIVGPLLSGFLVDHLSYQYAFGLTGATMVVATAVWLFAPETLPRVRSKAPDAEPVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH7</accession>
    <name>A0A7W7WYH7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046289">
        <property type="entry name" value="DUF6326"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19851">
        <property type="entry name" value="DUF6326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17149" checksum="1E8F6419AE38DDA3" modified="2021-06-02" version="1">MRTTLEDQRVPVRAKLAAAWTSFMFLYAYVDIIAFFKPGVVDDILVGVVWEFDVSQGLLIVFLSLMAIPIAMVVLSMTLPARANRITNLVVASVQVPYAAFNLVGESWTYFYGLGFALEVIVLALILRYAWTWPRTAPSATVATSPDRDTVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ31</accession>
    <name>A0A7W7WZ31_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045045">
        <property type="entry name" value="RTM2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="PTHR43670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17302" checksum="D733CDA39253D31E" modified="2021-06-02" version="1">MTLMRFDPFRDLERLTEQALAGARGPRAMPMEAFRRDDRFVVALDLPGVDPGDVDVTVERNVVTVRAHRVPLRQAGDDLLVDERPQGEFSRQFFLGDNLDSTRLSAEFDRGVLMLGIPVAEAGKPRKVEIGTGSETAEKKPRIPERASREETANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ37</accession>
    <name>A0A7W7WZ37_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="30043" checksum="978703D015BFAB76" modified="2021-06-02" version="1">MATYTVDGVPLDHPAGCWKLLAATQVRPLPGARAASVVIPGRPGELPLVGADVEATTIGLTLGITGASPTGIDQGAAGLDANLAALYGLFGVRHRMLELRYRPAPTVAEVAAEATVTAASEPQMWVGAARARLAVIARIPGAFWRDVAARVWSTPEPGFPERVTTLDGSTAPVSDTVWRITGPISDLRIADSLTDSWVSYPGTLDAGRQLRIHCGRLDAHEAASIAWDGTSAGATGRITNGGPGSARGWLTFTPVPVTSAHDRGVQVLIGGTGTSSATLIEMRARRAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ49</accession>
    <name>A0A7W7WZ49_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="28263" checksum="58E94DCCE043548C" modified="2021-06-02" version="1">MRNDSRLTLDAAAKALDMSRSSLHRTEKGETRVSVHLVKSMMDLYDVYDPELIEQVRRARENGWWTMYGIGDQGYIDVETEACAVHDMSLLLIPGLLQTEDYMRAVFEAHSVGQSRSLIENDVRVRKIRQRRLYDADDPLRLVALLDESALRKMVGGESVMREQLAHLHEAARLPNVEIKVLADGQGAHFGMMGSFTLLEFSEAEELPVLYIEHRFGAIHIEEGPQLDEARLTFEHLAAQAVRIEEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ89</accession>
    <name>A0A7W7WZ89_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25300" checksum="9382C9DE682D77F3" modified="2021-06-02" version="1">MELPPAWLRPDPLRGLAKVPWSGLDRGVGVDGWLRTAAEGDDAACTALADRLLDDDTVSEASAAAVPFLAGLGAGYQVPGAVRDRVIFLLAALASAGAGFTDAGRRTRRRWNPLGRELPRRPPDWITQTRYAVAKAAPRVFESLARAEVACALALAIAVPEVAPAHVADTAEGLAAGRGFLADAAAVVLHLTQDVTTDARFVRALAARHPTITVPDAPHRPDRVTLQLVGHRVAHLAAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZM6</accession>
    <name>A0A7W7WZM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031529608" evidence="1">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="33336" checksum="1440AA202189E29A" modified="2021-06-02" version="1">MRRLGIVVVAVALVVAGCGGKREPAARQAGAAECEAAEGRITIATGNSGGVYYVIGGALAQVISANTPLKATAAETGASVQNVQQLVDGTYDIAFSLADTAADAVGGKGAFEGKPQKIQALTRLYPNYTQVLVRGGINSPADLRGKRVSTGSPKSGTEVIAQRLLRAAGLDPDKDVQAQRLDLTKTADGMKDGSLDALVWSGGLPTAQITDITTSLKGDVHFLDLTPQLEALRQVNPVYDRGVIPAAAYGQPADVPTIIVPNVLLVRDDFPISNACAVTKAIYEHKGDLEKVHPAARDILRDQAGLTDPVPLSPGSLDALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X007</accession>
    <name>A0A7W7X007_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022532">
        <property type="entry name" value="DUF3696"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014592">
        <property type="entry name" value="P-loop_UCP034888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12476">
        <property type="entry name" value="DUF3696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034888">
        <property type="entry name" value="P-loop_UCP034888"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="3">
        <location>
            <begin position="228"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3696" evidence="1">
        <location>
            <begin position="315"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40089" checksum="0E5D2DE48E18829A" modified="2021-06-02" version="1">MIDLVEILNFKRFRSAEVALRPLTLLTGLNGTGKSTLLQAVLLAKQVAEIGPSGSVLLNDVHGLALGEAQDVLHPLAEDQEIDIRLTCGSERLHVVFEVPVRRSLNLAFEVDGGVPASLALVSGRRFAYLNAERLGPRDQHAMTGADIDSLGVGERGQFTAQVLAAHETSLVADGLLHPDTESRARGVRTLRTQVELWASEIIRPIEITAAWRPGLSTSTIRFREPGLFGGEIRPGNTGFGISYALPIIVAGLRMEPGGVLIVENPEAHLHPAGQSRIGRFLALLAFNGVQVVVETHSDHVLNGVRLAVAEGRCVPHHDVLVHYFSFDDADSTPTSIGMTERGSLDVWPKGFFDQLDVDLGGLSRAGRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE2</accession>
    <name>A0A7W7SXE2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-inositol-3-phosphate glycosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.250</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="7">GlcNAc-Ins-P N-acetylglucosaminyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mshA</name>
        <name evidence="10" type="ORF">F4559_000096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:26188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:58892"/>
            <dbReference type="EC" id="2.4.1.250"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase group 1 family. MshA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.250" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102710">
        <property type="term" value="F:D-inositol-3-phosphate glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01695">
        <property type="entry name" value="MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017814">
        <property type="entry name" value="Mycothiol_biosynthesis_MshA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03449">
        <property type="entry name" value="mycothiol_MshA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="9">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="209"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="1D-inositol 3-phosphate binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="44267" checksum="17E1EB248CFF5E39" modified="2021-06-02" version="1">MKRVAILSVHTSPLEQPGTGDAGGMNVYIVQTATRMARLGVQVEIFTRATSSDLPPVAELAPGVKVRHVVAGPFEGLDKNELPGQLCAFTAGVLRAEARHEPGYYDVVHSHYWLSGQVGWLARERWAVPLVHTAHTLAKVKNQALAACDAPEPRTRVIGEEQVVAEADRLVANTDVEAAELVDLYTADPAKVLVVPPGVDLERFVPGDRAADRAALGLPADAVVLTFVGRIQPLKSPDMLIRAAAEMVVRDPGLRSRLVVLVVGGPSGTGMKMLDELRDLAAGLGVADLVRFMPPQSGAALARVFRASDVVGVPSHNESFGLVALEAQACGTPVVASAVGGLPVAVRDGVSGALVAGHEPTAWARALEAIALNPAYRGELAGNAVEHAHRFSWERTTRSLLDGYEQARDTFREEVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE3</accession>
    <name>A0A7W7SXE3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="32" mass="3873" checksum="FBCBA6EC7B5802AA" modified="2021-06-02" version="1">MEHFFTGLLVFVSLLITWFAGYVVYRLYSDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXI2</accession>
    <name>A0A7W7SXI2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase/guanosine-5'-triphosphate, 3'-diphosphate pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.11</ecNumber>
            <ecNumber evidence="3">3.6.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.11" evidence="3"/>
    <dbReference type="EC" id="3.6.1.40" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008894">
        <property type="term" value="F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="36060" checksum="8EED705912EC8645" modified="2021-06-02" version="1">MRLGVLDVGSNTVHLLVVDAHRGAHPTPMSSEKAVLRLAEQLDDAGMLTRDGADQLVRTVAAMKATAVQLGCADLMAFATSAVREAANSAEVLDRVRAETGVDLKVLSGADEARYTFLAVRRWYGWSAGRLLSLDIGGGSLELAVGQDEEPEEAISVPLGAGRLTRTRFHHDPPTRAEVRETTEWLAEQLAPVAKKLLKGGTPDRVVATSKTFRTLARLTGAAPSSAGPRARRVLTDAGLRQLIAFISRMNAADLAELEGVSPSRSHQLVAGALVAEASMRALSLHELEICPWALREGVILRRLDHTNGSDQETPPARARRSGETGRNGRHGARWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXS6</accession>
    <name>A0A7W7SXS6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="131"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="519" mass="54635" checksum="2B195216DE08876F" modified="2021-06-02" version="1">MNWTLIVLLVLPLVGSVVVGLLRRNDAVAKAIALTVALLELVVAGFAWVGYDPDGARLQLTSSADWIPKFGVHLSFGVDGIALVMIALIAVLVPIVIGGSWADRLPEGRSAGGFFALLLAMETGMVGVFAATDVFLFYVFFEAVLVPMYFVIGRFGGPNRQYAAMKFFLYSLLGGLVMLASVIGVYVAAADKLGAGTFDWATLVTVTRDLPLEHQIWLFLGFFVAFAIKAPLVPLHTWLPDAGAEAPVGAGVLLVGILDKIGTFGFLRYCLPLFPLASKELTPVVMVLAVAGILYGSLLAVGQSDLKRFVAYTSIAHFGFIALGIFAFSSQAGTGAVLYMVNHGISTGMLFLVVGMVMARGGSRLIDDYGGMAKLTPVLGGLFFLAGLSSLALPGTNSFVSEFLVLIGSYPNQPVYTILAAVGMVLAALYVLWLYQRVFQGPVRGTALVGATGGPGAVVDPEKATIADLGKREIAVLAPLVVLVVLLGFYPKPVLDVITPSVGATLTEVGVVDPVQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXY1</accession>
    <name>A0A7W7SXY1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16532" checksum="2CC3F8993B8EA5E0" modified="2021-06-02" version="1">MAVPYGTRFAAAFDQVFPMGALMVGEVAPDMEYLSAEDKARGKHAKQRVDERTGKRQWKVVVTDPSAEKERDASVTVTLLADVQPVPPDSVQVMPGIEVRPIAFDGLTVEPRVMGDRYKYQGFAIRATALVSPPGSAARRTPDKTVNESKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY08</accession>
    <name>A0A7W7SY08_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16823" checksum="9D4BE163481AB2EA" modified="2021-06-02" version="1">MTPVVTIAPLREEDVPECVRIEHESFPADDPWSADAFRGELRAGHHYVGAYVADELVGYAGLGLTDFESSVHTIAVDKRWQGNGIGRTLLRTLLAVADERRVPVFLEVRTDNVPAITLYVAHGFEHLGRRRRYYQPSGADAYTMGRPAKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY41</accession>
    <name>A0A7W7SY41_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase YbcI (DUF457 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="27721" checksum="8CCE4ED997707DF2" modified="2021-06-02" version="1">MSTGPTHAMSGLLAWAAVTALADNHPIGQLTPQSWVVGAVLATGAALLPDLDHPSSTISRTFGPVSSAASTLINTTSKLVYRTTRTKKDSKRDGGHRGLTHTLVFAVIAALVTTAVVQQSQKWALPALMFVFAGLAVRGIMNDWNPKKDALMITGVSAGVTVLCVAWTAQTPASAAACGVAVGVGCVAHFLGDAITEQGCPILWPVPIGGKTWFPVAPPKIMRMQTGGRVEMSIVGPVVTALSVWLSAAALQQAGALPFLDGIDLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYB2</accession>
    <name>A0A7W7SYB2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="16209" checksum="BC911BFB59AD0CD9" modified="2021-06-02" version="1">MDLDGQAENVKHLEFIQGVITRVANSSFLIKGWTLTVTAALLGFAAQGSSRRLTLIGLVAVVGFWVLDAFYLRQERLYRKLYDDVRRDLDFERFSMDVRPYRKAVPLWRVLFSRTLLVFYGALVLVTLAILIFAPIVQKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT4</accession>
    <name>A0A7W7SYT4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7707" checksum="A806D48D4A4E374E" modified="2021-06-02" version="1">MVPVLVETVGIAYTAALLLSAAVATLAKDDRRRSDARRVLRLLLIKPRWPPDDGPRRRDRRTTPTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX3</accession>
    <name>A0A7W7SYX3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030995485" evidence="3">
        <location>
            <begin position="22"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="619" mass="64023" checksum="A4F208000B5134C2" modified="2021-06-02" version="1">MWPAKALVVVLGLLVSPQAQAAPQPSEGIELVRVGDRDHPRVRLADGRWWYVAPGCPWPSSEIPRDAVCGGDQVLLRDDADLRCTFVVTHRAEVTPSRVTWRFCLSRPPLSPEFHWSEEQNRARIAQLRTAIGACVGTEQVCLPMQWWPRRSDGGIDCGRIPADRLGDALAVVPHRVGMVCAVLDSYLLERPLPAVTAADLNLVGRAVADGVPVGGGTAATVGGGVLGDSLDAACSIPALVATLGGLCVGAVAVEAGASLWGVMDCGREFDKCLAEAAARSMLAGLDLTLGALRNPTPVKFDDPGLRTVLGAAGTVSAYLLLALLLVNAVIAVVRMRLRELAESGIGLVRWAFGLGAGLAVVASAVFVSDRVADWLAGSTAGTAEAVYARFFGLMRVLAAGGPDVQFHGWLLVMVVFLLGAFCAGVAYLLLVFRSGAIVLAVTLLVLQLAGGAGPAVTRSWTRKGLSVLWACVVAKPVSVLVFRLGETWIGEGRGVGDLLVGVGMLGVASLAPFVVVKWFPLDGGRGGSGRGSVPMVVSSGLAMAGSWAAPRSASVPDRAPAVSVRPLPAVAAVGALAAMAVQSTVDGVVSGGADESPFPDQVPWVPPPVGPTSGGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ39</accession>
    <name>A0A7W7SZ39_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">F4559_000937</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="28704" checksum="E6A53CB765C8EF26" modified="2021-06-02" version="1">MTTMVLADGAEFTAPGVKDFFLPKIIEPYVDKPMILLVLSIVIISVFFLVATRNLKIVPGKLQFAAEQVYDFGRNGIAREQIGAKDFKPFVPLIVAIFTFVLVNNLFGLIPIVQFPTMSHIGFPLAVSLFVVYPVYHFVGFKRHGFVGYLKHQTIPPGAPWFVLPLLIPIEFFQKFVLNPITLAIRVFAAMFAGHLLLLVFTLAGEFLLLNGGITVIVGPISIAFAIALTFLEALIMVLQAYIFALLSASYIGMALAEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB5</accession>
    <name>A0A7W7SZB5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9613" checksum="AE24461BFE83B42F" modified="2021-06-02" version="1">MSSSLPTPQEIRDLRMAARLSQVELAQLTGLSRNTVQAAEQGRLTTRTARALGCVLRELQVPSDRLTQVERQLADLTAQVEQLARGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB9</accession>
    <name>A0A7W7SZB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000984</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="8">
        <location>
            <begin position="271"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="40126" checksum="05B731DDFF9648D6" modified="2021-06-02" version="1">MSGSVIVAGARTPMGKLLGSLKDFSGARLGGVAIKAALERAGVAPEQVQYVIMGQVLTAGAGQIPARQAAVAAGIPMTVPALTVNKVCLSGVDAIALADQLIRAGEFDIVVAGGQESMTQAPHLLPKSRGGYKFGDVTVQDHMQLDGLFCAFDQVAMGASTEKANARYDLTREEQDEFAARSHRLAAAAIANGVFAEEIAPVEIPQRKGDPLLFATDEGVRADTTVEGLARLRPAFSADGTITAGSASQISDGAAAVVVMSKAKAEELGLTWLAEIGAHGVVAGPDATLHEQPANAIKAACAKAGITPDDLDLVEINEAFAAVGIVSTRQLGISPDKVNVNGGALALGHPIGMSGARLVLHLALELKRRGGGVGAAALCGGGGQGDALIVRVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF3</accession>
    <name>A0A7W7SZF3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase YbcI (DUF457 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25587" checksum="C055A48056C1314D" modified="2021-06-02" version="1">MLGSTHALTGWCAGLALAPLLGAHGLGQAVTVAAVTAGSALLPDLDHPGSRASRFAAPVTRLLSRIVQGLSGLAYRATRGPRDEDLDGTHRHLTHTLAFAILVGAATTWWVSSSGTWAAVVVLAVAVLLAVDALGDWVAAAVVTVWLVWVGRGDPGAELAAITGWLGIAVGVGCLVHCLGDAMTISGCPILWPVPILGETWYELGPPPWWRFRTGGRVELWVVWPVCVVAAVLLLPGVWPWITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF4</accession>
    <name>A0A7W7SZF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="30028" checksum="161E979A742D077D" modified="2021-06-02" version="1">MTGMDIVAAIDQAIGCEQCGRPLDDSPSDLWCSEGCQQAWQSARTTPLTGYREPWGGYYPEDYETGRVPRSAAENRVGVSVSAWFSAYHAGIVGVADAFTAMGYSESEAQRLSQRFSERRDASLAPRVLVHDAGTLFTGSVDGWREIGAVAGSVLVDVAASTPGTDVDQRRGLDALREHGADLDVEDVEFLSHHGHEIRTRLSDTIRGVEFTAAFVDEAFVDSLFRASEGMAELAAVVREVDDRQARALEARRNRNTGPRRTPRPPRSINANKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG5</accession>
    <name>A0A7W7SZG5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="56" mass="5980" checksum="0342FFE245450C7A" modified="2021-06-02" version="1">MPKLRWKKSSKSGSNTGCVEISNRFDAVRDSKNPGGPALEFPAGAVKSFVAALRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ5</accession>
    <name>A0A7W7SZZ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (TIGR03083 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26286" checksum="718548E9DC00CCEC" modified="2021-06-02" version="1">MEHADYVAHLKTQYTAAHAALVTNDPVAPVPNCPQWTVFDLVKHLAGTHSWALTALSTPPDGAWPAIPDRPDAWDDLVPWWEGKFAELADTLERLGPDAPAWTFVPEKKSGVWARRQAHETGIHHLDALSARDAEAPALLFDPEFAADGVDEYLTWILPLAAERIPIEVEGRVLLHAADAGRTWEVVVGPDRKPSVHAVTGSGTDADATVAGTADAVYRAVWGRPGGAIVSGDRRLFDGLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0F8</accession>
    <name>A0A7W7T0F8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19673" checksum="8658E3F645337B25" modified="2021-06-02" version="1">MTRQKLFDAALRLVGERGAAHVTVDEIAAEAGVAKGTVYYNFAGKDALVDELLRHGVDLLAARLRAAESADDAVPALVEGMLGFFAEYPAFGQLLVGELWRTPGQWHDTLRLLRDDLVSIIRGHMGRLADTGRLPAGVDVGTAAAALFGTLLVVAVDWQVFQPERTLAQTRDAVLVLVRGLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q4</accession>
    <name>A0A7W7T0Q4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="8817" checksum="878FDF6399FEF4D2" modified="2021-06-02" version="1">MDGSDVELRVATRTACPPTVRAVAAHSEPAVDPAHAVCPVCGFPRAHLRSRAVTRPGRPSLPWRVAVTDGRDLPHVESRCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z4</accession>
    <name>A0A7W7T0Z4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="25068" checksum="78D484746B999FC1" modified="2021-06-02" version="1">MSDVRSPEAPRRPASEDPVGTVWFGVLAWPSIALGVVGLACSPVLGINRITAIVAGVGVVLGVIALFGGRKLLATVGVVLSVLAIASTVVVRTGSTDVATVGGGATASPSAAPDGLTWNQRFKWKDGLVAEIATPTVCTTGTFAVPRKINRAVKVTITVTNGTDRPFDAAVLTRVGGDGKFDNRKADLIQDSPDGGCGGGVETQSVAPGSSFTYDVAYSVSPQTGKLEITLQPGFNADKAVFSGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T137</accession>
    <name>A0A7W7T137_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">F4559_001985</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="23186" checksum="B240FF01FB8210E2" modified="2021-06-02" version="1">MVQHPMIAPSILSADFARLAEEADAVSGADWLHVDVMDAHFVPNLTLGLPVVRSLRKATDIPLDCHLMIEDPDRWAVGYAEAGAYNVTVHAEAAADPVALARDLRAAGAKAGLSIKPGTPIEPYVDVLKHYDTLLVMSVEPGFGGQSFIADVLDKVRTARRLVDTGHLTLVVEIDGGINADTIGQAAEAGVDCFVAGSAVYDAADPGLAVEKLRALAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T143</accession>
    <name>A0A7W7T143_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="556" mass="58857" checksum="41CD601D9AC18071" modified="2021-06-02" version="1">MTTPTPNVAAALPHYDLGPQIGRGGMGVVYSAVHRPLNRPVAIKRLPGVLAEDERMSARFEHEARLLARLDHPHIVPVYDYVRDRGEHLLVMEKLDGGTVWSRFTAEGFTPARSCALVLAMLSGLHAAHGAGVLHLDIKPKNLLFTAQGVLKVADFGISQVVSEGATLVTHAGQVLGTPAYLSPEQALGNPLTPAADVYGAGTVLYELLSGRLPFDSGGGALAMIQRHVHQDPRPLGEVPEPLASVVMRAIQREPRHRYRNAETFAIDLAGAAAAVFGREWLVRAGVPVHLTPQVAAASSRPAPDPAERRDTLDVPVRATIVEQVPPVVRFGQETLVPAHELLETRPARWFALAAALLAVLLVVLPFALPDRELPPLSADLGRPVPVMVPADTTTARLDVRLAGFQVAEAAGTIENGAAVFELPGAARWIVGGAVDAEVTTNTGGKSYSLRPTPNPMISIMGVGSAVLLLFTVAYLESLLRSVRRRRAGTAAIVASAPLGFGLGVAVLFLPSVLMRHEPQLTPALACGVLGAGAAVCLTIATRRLSSRVRRSPAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B6</accession>
    <name>A0A7W7T1B6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5133" checksum="050BD5700FA4E729" modified="2021-06-02" version="1">MSELPDLTTLPLSDPRSVRSPLLDRAIASTRARIAVGRCGDAVQGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E6</accession>
    <name>A0A7W7T1E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein with Yx(FWY)xxD motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031321946" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="17928" checksum="46C2C2E9939B7538" modified="2021-06-02" version="1">MRGRRTTGALLAVTVSTTLVGACGTRTPPAPDPAPAPRWGAQPHQMLAATASDRVGQFVADAAGFALYRSDRDSADPPQSTCDGVCARTWPPVLVSEHTMTAGVDPTLVGSVARPDGRRQVTLAGRPLYRHAGDRRAGDLSGQGLDGVWFAVTPEGRKAPAESATPSAKDGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T260</accession>
    <name>A0A7W7T260_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="41983" checksum="B2C80283EB4D19AB" modified="2021-06-02" version="1">MKRTPYWPVLTHPVLRKVLPGIGVSSIGDGMSTIAIAWLALLLAPADQKGLWVALAAAAYVLPGAIGAVAFERWLRGRSGAQLAGWDAVLRAVVLGAIAVVHFVGLLTPMVFVVLLAVSSLLAAWGKAGRYTLLAELLPEEHVLAGNAVVNVLLEFSTVGGPPLAALLIAWAGPAAVIALDAATFAVLALTYRAAVPPSARETRIKAPASRSTGLRTILSNPELVGLMVLSFGFFLFFGPVTVALPVHVSEDLHGTAVQLAGYYTAFGIGAVLGAIVAGYLKNWPMRVTTVGIVLGFGLALLPLGLSPSTVVGWIAFGLCGLIWGPFPSTTTVLFQRAVPADGLAPVLAARGAVMSLAGPAGALVGAPAVVLLTAQGTLAAAAVGMIVLAGLTAAFFLASHRKRVVDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T294</accession>
    <name>A0A7W7T294_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="32"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="194"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="370" mass="38171" checksum="B91C859C72CB3834" modified="2021-06-02" version="1">MHPKVTRAAVLREFRAPLDVVDVPLPAELPPGSAVVRITKTTLCGTDAHLWQGVLPFVALPIVLGHEMAGEVVALGPGAERDAEGRPVSVGSRVVWSESVCGLCHACTVLREPVLCTDRGYGFSQRADVSPYVVGGLSEYAYLPPGAHRIVLADDMPDHWAASAGCAVKTVLRAYANAGGVEPGSTVAVQGAGPLGLIATAVARACGAGQVITLGGPGNRLALARGFGADSTIDVTDVTDPDERVAQVEELTGARGADLVLDFAGAPTANREGVLMCGKRGTHVVVGLAGPDAARVPMDVVISREIRVVGSLNGDVGDLSRALRFLSAFADRFDWDAMFSAPVGLSGAEQAIRDMASMAAVKAVVDPGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E7</accession>
    <name>A0A7W7T2E7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="45" mass="4766" checksum="0BCA2C481887DFD3" modified="2021-06-02" version="1">MANDQINPVSDDVEITAVVELDDADLDTVAGGYGEYGSGRRIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F3</accession>
    <name>A0A7W7T2F3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="506" mass="52410" checksum="32889B0179C39755" modified="2021-06-02" version="1">MVRVVLAVVALGCAVVSVSFPWSDVPRADPLWAVVGVGLVVVAALTLFARGRVVALIVSVVALGFAGWVLVGDLSSGVSGAGSAVLAVGALACVAGALSGWWGVPVLAVVLAVVAPFAVSTVDSATVDRADVGAVVARPAGVLWRWTAGAPVTGAVVAGPGIVVGTATGEVVSLTAGGGTTWRYARPGTSNVSLRTTPDRTLVVAAFEGDGPFLRKQDLWVLLDASTGEVVREWAGRKAAPTTPRPTDRVLVEWEGVDRAEGGQDFRITAVDLRGGQELWTWRAPEGCRAPLPVVDGAADTVLAILACGDDWGLVGLADRDGSERWRALSPVPKGESQDFVTDVGTDGRLVAVTSNFITGTLIRAHDGHRVATDLSSEYRFWAGTGPLAVGVVRDRDDKIRSVAVVDPGTGAVTPVAEVPCPRQRTMATTATTFLRLCDTEDGAELVWQDLDGTGTGRSPVPDWARPSSRSLGDFRSAFWSEGILPAPGFVALVRLGETGVVGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2I6</accession>
    <name>A0A7W7T2I6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Beta-glucosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="2 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="414"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="456" mass="49898" checksum="FFA2DB8992F740E9" modified="2021-06-02" version="1">MDQVFPSDFLWGAATAAFQIEGSVRADGRGPSIWDSFAAVPGAVLGGAGGDPACDHYRRHTEDVALLSELGLPAYRFSTAWPRVMPDGRTPESRGLAFYDRLVDDLLDRGIRPLVTLYHWDLPQALQDAGGWGARDTASRFTEYACAVYDVLGDRVEDWTTFNEPFCSAFLGYGTGVHAPGVRDEGLAFVAAHHHLVAHGTAVRALRGRGARKLAIVLNFSPVLADSSDDAHLDAVRRFDGLHNRFFLDPVLGRGYPEDVRADLAHVPEFSRAVLDGDEALVAAPVDWIGVNYYAPTRVVPLSGPEIPSNSGLPGLRGVDVLPPRGPLTSMGWEQRPESLTDLLVWLGKRCGGVPLVVSENGSAFTDVVEPDGRVRDVRRKRYLAEHLRAVHAAIALGADVRGYLAWSLLDNFEWSFGYTQRFGLVHVDFETQRRTVKDSGRFFAEVVARNAVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K9</accession>
    <name>A0A7W7T2K9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like chromosome segregation protein Spo0J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="31"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="35888" checksum="DEBF4E26F38BB5A1" modified="2021-06-02" version="1">MDVRIAGVVEPDPSSNTCQESDDPDSRFTLVTLPVCDLLRSESPRTAGESEEHAKLLAESHGELPPILVHRETMTVIDGAHRLRAAELRGERMIRAQLFDGSEIDAFVLAVEANTTHGLPLSRADRLAAATRIIESRPQWSDRAVARVAGISARTVGVIRRRASADRAQLPARVGRDGRTRPLSTAAGRRIAADLLRSNPGDSLRRIAAAAGISTGTVRDVRDRIDRGEDPVPPKSRRAEEHAVEVIAPRVGDSLSIARNLRMDPALRFSETGRSLIRLLDAHVPILEDRERLATNVPPHAAGMVAELARGYAEIWQRFAREVERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N8</accession>
    <name>A0A7W7T2N8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="3">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="32131" checksum="87B237F7D5BEE888" modified="2021-06-02" version="1">MGAATPGASRGDVGSAPGSGAAPGAWVDVPAESDRRDLSRSGAAGGVGEPRSEREAGYLGPVAPGRPDAKRPLPSTHVDGAVDGPPCPRCGVPNPPGRRFCRRCGEPLYDQAVASSGRRRKRRWRGDRSRWLRRSAAAAVAVALAVTLWVFHPELLALWEDLRDRLATPAPVAPTSVTANAAVPDHPATAAADGLSNRYWGAPAVGDAVEFGFAAPFRLLSVVVHTGASAEKDGFAAQARPSALDMVVTTADGTTRTVPITLADQPGPQRTDTGIGNVVRVRLVVRSATGLGEGRHIALGEVEFFRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T300</accession>
    <name>A0A7W7T300_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4151" checksum="11F1B46B2D6B58AC" modified="2021-06-02" version="1">MRPPVSADEWLFHFNGSVPGSLVYHAIAAAVLSVGGVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T349</accession>
    <name>A0A7W7T349_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purN</name>
        <name evidence="5" type="ORF">F4559_003038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="20914" checksum="F9C950E27DB4836D" modified="2021-06-02" version="1">MARLRVAVLVSHTGSNFRALHEASLRPGAGFEIGLVVSNNSGSQALAYAREQEIPHRHLSSHTHATAEELDAALVEELTARSVDLVVTAGYMKKLGPRTLASHGNRIINIHPALLPRHGGQGMFGSAVHEAVLASGDRVTGPSIHYVTAEYDAGEVIARHEVPVLPDDTAESLAARVLAAEHRLLPEVVARIAAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3A6</accession>
    <name>A0A7W7T3A6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28033" checksum="B458748CB18FA1D3" modified="2021-06-02" version="1">MNTAYREAAARAGLLRSLAGAEYVAGESADPLLGTSRWLVEYADDRILDDPALLDAMLTELGAEHTVLLRTEGDRVLTGPWTRRLTYLRLDEEPTAGTSALHCGPEADGDGPLVAEWLARALLAGEATADPADVRAAVAAIRDAPDRRTLVVRRGTTTIGHATLLTDAYDEATGDDFVDLVDILVDSEPDRRDATAQLVAASWRVAAELGRPLVGNVVHHSGGQRVLDSLLRRGWTVCHTYWTTNSNGSTQVLRTTGPAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V5</accession>
    <name>A0A7W7T3V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30751" checksum="2117B9074A85CFE6" modified="2021-06-02" version="1">MTLPYGPDDDSAAYHYINAALRGREAEAWRLLASDAHVEQTDRVMRAMLDRITVARKHRTAQRAKARAQAASGEITQEEYRRDAAEDAARASKTAHFETLLREQYRSIGQAARRLRGDDVRAELTDLVVALGAAVDAHRAAVLAGGYEPTAADRSLWERLATLDAPDGTGRTSVEELVQRHTERQDDFGRVLAGIVLDVAGDATSVPRAAVATAWKRTVAPTLAPEQKAEFAAKGKGSLATEKLRKALGHLERKGLVKRSEAADGQRLDLLDRRGLEDLADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T411</accession>
    <name>A0A7W7T411_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20406" checksum="F6C4D42AE46C3869" modified="2021-06-02" version="1">MPQEVELPPTPRTPRERWLDAGLEALVEGGPDAVRVETLATALGVTKGGFYGYFAGRPALLDELLDEWERRCTDDVLARVEAEGGDARDRLRRAGGLTSSEDLHRLDLAVRQWARRDEAVAARLRRIDAVRLDFLRRMFATFVADPDEVEARSTLMFTLAIGRHFLAADAEAVRRAGEHLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C5</accession>
    <name>A0A7W7T4C5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cas3_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041372">
        <property type="entry name" value="Cas3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18395">
        <property type="entry name" value="Cas3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas3_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11835" checksum="ED017CB7BB67E656" modified="2021-06-02" version="1">MIKVVLLHADHAVLTPVRGTIPVDLNGEIDVDSVLELEDSVTMLSAPDGVPDEVVEFLGTAPVPPAFARSPWLRRHRPLVFVDGRCTVAGHTLRYERDYGVYVEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F8</accession>
    <name>A0A7W7T4F8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5867" checksum="BC723227C972B2EB" modified="2021-06-02" version="1">MSVPPTAVDKPLPARSAEAVLLLPIIKRLRARGWWCPRIPPAPGRGHLDRYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I4</accession>
    <name>A0A7W7T4I4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="34173" checksum="EC9A67D3B9681876" modified="2021-06-02" version="1">MAVVVLRRLRDLVVVLFVVGTVLFFLLRSIPGDPAQVLLGTKADPAQLDRLRRDLGLTGPLHEQYLTWLGNVLTGDFGTSIKYQLPVPQMILDHLAPTLTLAVLGIVISFLLTVLIVTWATVSPGNRVARFVGRAAQFGLALPEFWLALLAIYLFALTLGWFPTSGYTPFFEDPPTAIAQLALPLAVLVIGQTAFLTITMEESVLGELSRSYLRTARAKGVHERRIMVRHVLPNSMLPVLTTAGLNFASLIGGVVVIESIFVIPGLGTMLLGAVYARDFPLIQGGVMFVAFLFVLVNLLVDLAYALVDPKVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4L7</accession>
    <name>A0A7W7T4L7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="576" mass="61591" checksum="0964CCC04ACDBDFD" modified="2021-06-02" version="1">MTEAGIDALLVDRLSTGAGRLGWEYVEPRPVAAGPEDNRPPVWVEPAPVLPPDTTGRNVFIGCGTFLLVGSLMCLPFLVVSDSARPVLFSLIGLGALTIALPTVISQAKAKEAEKELRARREFHWTEFQRGHRQWQERVAAHNAAELTRWVSTPRWYPVGPRRRPGRVDVFGGSADGWAALLATYGSTLLDEGVFVLDLTEQWVADGLTGIAERSDLDVDAIAFPTDGLDVFAGLPDGEIAELLAAALGAAQEDVRALHVDLIGAVLDRLAGPTTLSRVVAGLKTLRGNHVEGALSEAETDLLTAAADTVAGSEQARRELRFITGMLDLVTAAEPADAFDDLWPESGITVITTVGPHQRRKNFADRLLFHRVLHRLRDTPLGTGRGVLVVAGADDLGGAALRELARQAERAGVPLVLLMRTLDEDLQPLLGSADSVAVVMRLGNAREAAVAAGYLGREHRFQLSALTFEVGRTLTGSRSYARGGAQGTSTTTGEHGVTTTRTSTWQRTTGYAEADSTGRGATLTRSYEFAVEPTTIQSLPVTSFVLVEDGQSGRRVVLGDCNPGIALLDKVSPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q7</accession>
    <name>A0A7W7T4Q7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="917"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1188" mass="128327" checksum="6E48E9CAAC13ED9B" modified="2021-06-02" version="1">MEPHLATSLFVRLDRGEPVEAIGPVLYEAVLADQEPDDATVFLIRRCLDTLPPDHPWTGSLLHLHSLALVRQEKWAEAVRLAEASLDAPFPVPEFRYGAIIHFSEVHCTLHEAGEEVDLDRVIGTLRALLDQVDEPHCHAIIATRCAYLLAARDTGEDAVDAARMLDAAIPVLPADMPGLDGTFRLSAAIAAELAERTGDPALLDAAVEALDRAIACTGQRVADVEQDHATLALTLIRRWPDERPTDVRDRIVDSLAKAVAAGYDDLWPWYGGELCARGEATASPEDLRVGIRWLDRYLATPEDDGLSRTAIRTNAALAHRALWQSTGDPSHAAAAQNHATVLLGHDISDGERVVMHRIRLDPMVPVSGRDTDPPVLSWIAQARGFVESTDHPDLEAVAALAAIVTFVELAAIASGELAIRLAAGETFESMFGSLLDVVRRAPDEYAEMVTLLSDLYRNYDLVLHGDSDTDHSATLEVLKQHRDDPDWGDERAVVALISTFLGVRIGNLELLDGSLAVHPAAIDLFRALHTDAGFEEISQRTIEARAALGEEQGIFTEFLDYMVAMLGEGPLPENSSPLMRPFRTAVDILDAIRRDDIDAIRAACRRLDVEVATTPRSAVRRHDLAANVRAIAYSTLATFDTEDAHATLTAIMEEGTRWDSAVADRDPGILPTAEKLAWLLRQRGGPGDGERARRVGFEMLFLSWWRVLMQTSDDHALDVARTASANAGQFVSWFLADGALDDLVRLLDASRGLVLGAAALSRTASGKLTALGHADLAARLAAPAADPIATVELRHRVIRVLADADAGLADPPTTDAIREGLRRNDSDALCYLAPRTEHHDGFLLLVPADGPVEVRGLDLPAADDIESAPGRYGIALDGWNRAATTDGPEHGRWRDALAELCAWAGEAVGRTLLTVLGDRTRVVLVPIGTLGLVPWHAACHDGRHLLEDLTLTTVPSARVFLDLVDRPAVTGTPVLVGNPDRRLHAGAHEIALLNRLHYADAVCLGLRPTHRRPTPTFPDGSGTPEQVLARLGEPVSVLHLACHARADMRHPLASSITLSNGELSARTLLGLEPTGTLALGVVALAACETGSTWVDHDEALSLATTFLTIGARSVVGSLWKVPARGTTRLMALFHHFLRTEPPATALRRAQLCLLDPDREPPPAALGLPAGEHDRDPANWAGFVASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V7</accession>
    <name>A0A7W7T4V7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AraC family transcriptional regulator of adaptative response / DNA-3-methyladenine glycosylase II</fullName>
            <ecNumber evidence="10">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052822">
        <property type="term" value="F:DNA-3-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052821">
        <property type="term" value="F:DNA-7-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="490" mass="53478" checksum="846B54DD731A5E8E" modified="2021-06-02" version="1">MHTDVDRCVRAVQSKDERFDGWFFTAVLTTRIYCRPSCPVVPPKPENMRFYPSAAAAQQAGFRACKRCRPGASPGSPQWNERADLVARAMRLIADGVVDRDGVPGLARRLGYSTRQVERSLTAELGAGPLAVARAQRAQTARLLVETTTLPMTAVADAAGFASLRTFNETVREVFGMTPTELRARAKNVPNTLGAIVLKLPFRRPLFPDNLFGHLVATGVPGVEEWRDGAYRCALRLPHGHAIAALTPHDDHVACRLTLSDLRDLTTAINRCRWLLDLDADPVAIDERLAHDEALEPLVAKSPGRRVPRTGDPREFAVRAVLGQQVSTAAARTHAGRLVQAHGDPIEDREGGLTHLFPTPAALRDVDPDTLAMPKSRKATLLGLVSALDDGALELAVGGDWVEARRTLSELPGFGPWTVESIAMRALGDPDAFPATDLGIKTAADHLGLPVKPKQLLDHATRWSPWRAYAVQHLWATGDHPVNHMPKDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S8</accession>
    <name>A0A7W7T5S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="20695" checksum="5073E3E37CD20B86" modified="2021-06-02" version="1">MSGVQDQLLRSLVKVATALRREGIPFALTGGCAVYARGGPATEHDVDILVREEDAKAAQSALVATGMTAAEAPEDWLLKVYDGDSLVDLLHRPNEIRVTDDILGLAEELAVGSVTLPVMPATEVLISKLLVLDGHRCDFSELLPFARALREQIDWDRVRRATSASPFAEAFLLLVERLDLIAPVVPVRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T615</accession>
    <name>A0A7W7T615_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycopeptide antibiotics resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="6">
        <location>
            <begin position="55"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="244"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="353" mass="37393" checksum="4DEC4D43E20C461C" modified="2021-06-02" version="1">MGIGIGVGTYLESVRAGFAAFVGVGALVLLPLAVLHYRRFGRVEPRRAFVLYGLLAYGLVAAALIFLPFPDPAAVCRGETMTSLRPFQWVTDMRANLSANGRSGLVAVVTSTAFLQQAFNVALFVPLGVVMRKAYGRGLLSVGCVGLGLSLAVEVVQYTGNFGVYACPYRISDVDDLISNTSGALLGWMLAPAAVVVPAVPSRTESVALPEAVSVPRRLVALAADAMVVVLAVLPDPRWAPVAALVVRVVAPAVTDGWTPGSWLVGHRLRTASGTRVPIHRLLAREVVGATGLCAYVVLVSPRWDMFAVDVAVVALVLLGAFVVPVFRRDQCGWPDLLAGTRAEHARRSLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T654</accession>
    <name>A0A7W7T654_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031238789" evidence="7">
        <location>
            <begin position="30"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="213"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1272" mass="131810" checksum="1A1DEE8A2CA968F0" modified="2021-06-02" version="1">MSARFRALAGAALLVCAIPLYGAPPGASAAPGGTPPARTAPAEPGPAEPASPHRVTLITGDVVVYDDNPAAARIEPAPRENGGRLAFTTTTNSRGVSVYPSDAVPLITAGRLDPALFNVTTLAAEGRTDGETPVIPVIAKTDGRPAALAVTTHLTGAVGLRVDKAQAPGFWNALKSDSLGLSKVSLDRKVKPVLDHAAPRSAPAAAPDPDAEGTGVTVAVVDTGIDVGHPDLVGRVAAEADFSGDGDTGDHHGHGTHVASTIAGSGAASGGKYRGVAPGATLLSAKVFDRTGSGDESQVMAGIEWAVAQGAKIVNLSLGAGVTDGTDPLSELVDRLSAEHGTLFVAAAGNSGSGDRTVTTPGAAASALTVGAVDRDDRLAWFSSRGPRLRDALVKPEIVAPGVDVVAARAAGTSMGTPVDDRYTSSSGTSMATPHVAGAAALLAQQHPDWTGGVIKDVLASTAKDVGLKWYEQGAGRLDIPRALTQRMTGPASAGFGRVEGTEPAAHQVVYRNEGGTPQHVDLSLGVQSWDGTPPKPDSMRLTTGSLSLPPGSTAATTVTVDPDAGPAGVYGGTIVVGDAQGGTIRTPVSTYNPPPAQPISVRVLDSTGAPATEALAQVVDDALGEGNRNDPFLDQVEHWVDLVGGVGRVSLPRSTYSVLGWVVENGLTARRWCGLGASELVVDKPTTVTLDCRAAVPVRGDTTVRTDQRDRTVTLRRVLPAPAGGVGNTTEIGLSAGAADWETRVTPAAPTKVGAISLQDYAILGSAAVDLVDAGGRRLDPGYDVGSVTGSLVGGHRFALVPPGGDVKGKAVVVRIAPPTGAADPVGAVDLAMSKAAQTAARAGAAALVAYVDLPGAIAPTPPVGAALPVFTLDQAQGESLRAKGGDVTITVRATPEAMFNLSVVDRNGVPKDRVRRYRPEDLVATRTAYHADQPGLTAGKSWYAFPDGLWKTQFVQGVGITAPGTWTEYTGPGDQRTVWKRVTTLGVPGRAALSINRFNVYKPGERTRPDEFWFRAPLRPGAVELNADHPGRYPSAEGRWRVPCSQCREGDMFTPALQWVDGQGFVSPQENSKYFATTTARLFRDDLEILPVKDPFARFPRFALAPRSARYRLEVTDVMAGAGRIGAPSTLLFGHARRIETTWTFTSSRSDDAPPPGYSCQHGDRCAFQPLIQVDYRLPLDVTNTLSGDTFDLAVASHTGAHDAGPVVWVHVAWSTDGTTWTDVVAKPRGGGVWSVAAPAASGDVSLRVDARDSRGNTVRQTIRGTYRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A4</accession>
    <name>A0A7W7T6A4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="1">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="7891" checksum="6B14BEBA914E51A3" modified="2021-06-02" version="1">MTAHTTIKGKRITGEARVKMAADLKKKYEKGASIRALAEATDRSYGFVHRILSESGVVLRGRGGATRTKTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6E9</accession>
    <name>A0A7W7T6E9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030980664" evidence="2">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20475" checksum="094E87F60DCBAE24" modified="2021-06-02" version="1">MNRRLAAAALAAIPIIMVSACTKTTTTGNPTPATEQGGTTSTSSPTGKDLNISRFTDRPCELVKPEQLSTLGKLKTPKQEVSILGPTCTWPGKDPTADNTYALTLVTKGSTFESMRENVKDRPIFKDTTVAGREAYSSDATNGTRDCGTTVKTSGKDAVLIQMTLGDEDTARTGKSCRESEKLAEIVIKNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T727</accession>
    <name>A0A7W7T727_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">F4559_005113</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBB4967754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19561" checksum="B9F269919E13F095" modified="2021-06-02" version="1">MTSRTLVLGGARSGKSAHAEGLVTDDVVTYVATARRYADDPEWEQRIAAHVARRPTQWTTVEAPTPDDLLAVLTATSESDPPILVDDVATWLTGVLDEAGAWDGAGADVVERHCAHLVGAVAQIRARLVLVSAEVGLGVVPGTRSGRLFRDHLGSLNARLAEVCDEVVLVVAGIPLRLREAGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N4</accession>
    <name>A0A7W7T7N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cation diffusion facilitator CzcD-associated flavoprotein CzcO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="344" mass="36908" checksum="0AA022BDC76324D2" modified="2021-06-02" version="1">MDVVVVGAGQAGLSTAYFLHRSGLEYVVLDAEDGPGGAWRHRWPSLRMATVHGIHDLPGMPFATPDPDAPARDVLPAYFAGFERRDSLRVRRPVRVSEVRDAGEGLEVVTDQGVVPTRFLVNATGTWTRPFVPHYPGAESFRGRQLHASEYAGPAEFAGRKVVVVGGGTSAVQQLLEIATVAEPLWVTRREPVFREEPFTPEIGRAAVALVEERVKAGLPPRSVVHVTGLSLTPAVRTALASGVLARRPMFERITESGVVWADGTEERVDAILWATGFRAALDHLAPLRLREPGGGIRLDGTRVVADPRVHLVGYGPSASTVGATRAGRAAVREIRAALTAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W7</accession>
    <name>A0A7W7T7W7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative unusual protein kinase regulating ubiquinone biosynthesis (AarF/ABC1/UbiB family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="436" mass="47958" checksum="7087D0148909229A" modified="2021-06-02" version="1">MSEIPRKAVQRTAKLAGIPLGVAGRVVGGWGKRLAGRSSEEVNAEVSAKTAEQVFAVLGQLKGGAMKFGQALSVFEAAVPDELAEPYREALTKLQTAAPPMPGRTVHRVLTEQLGSAWRSRFESFSDEPSASASIGQVHRAVWHDGRDVAVKVQYPGADEALQSDLKQLLRFSRLLQAIMPGTEVRPLLEELRDRYLEELDYRTEADNQRVFAKAFHGDANVVVPRVVASSPKVMVTEWTEGVPLSTIIRSGSVEDRDHAGRLLSEFHFSAPSRSGLLHADPHPGNFMLGADGRLRVLDFGAVARLPEGLPRTLGLMTRIALDGRSSDLVDLLRSEHFIRPGTELHAEDVLAYLAPFVEPLRTERFHFTRKWLQKQAERVGDLRSPDSQTGRSLNLPPQYLLIHRVTLGATGILCQLDATVPARAIVSRWQPGFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z5</accession>
    <name>A0A7W7T7Z5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="20351" checksum="E39DF102A513D76A" modified="2021-06-02" version="1">MEIWDITDMTAPRHIADIPVAKGDMPGLVYFVDDRHVAVVGSDGVLTVWDLTSPREPRRGTKTAFHHGLVDYAAFSPDRRTAIGVGDNGEIKFWDVMPDYALRQRARFTYPVQILGRSDIPRRRVPHAIRDNPEGDFHSVRWFPDPEDAATAVCAVDSARLTEPDWRRHFGDVPFRALCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T845</accession>
    <name>A0A7W7T845_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8755" checksum="44252A819B85E9B5" modified="2021-06-02" version="1">MSITTSHRPGLAITGWDLRMVSGMARHRVIRLGRRLFRRRPADDLLSRSIRSCPGCAADVHVFADVCRHCGGELEIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P0</accession>
    <name>A0A7W7T8P0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="11" type="ORF">F4559_005975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14229" checksum="FAAFFD7E567D949A" modified="2021-06-02" version="1">MIKGFKDFLMRGNVIDLAVAVVIGAAFNAIVTAFTSNLINPLIALFGGNDVKGLAVQLGSTDKTVIDFGAIITAVINFVIVAAVVYFIFVLPMNKIKERRKRGEEPGPAEPTDVELLKEIRDLLAAQQRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y0</accession>
    <name>A0A7W7T8Y0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11661" checksum="F7E26AC3816169C6" modified="2021-06-02" version="1">MGAEAAISVRHAEELAKTLKALAHPIRLRLVSLLAHEPDGEACVCAISAEFGVTGPTISHHLRLLREAGVLACERRGTWVYYRLNPDVLDPVLQAIPLTSTSPSIIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T916</accession>
    <name>A0A7W7T916_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N,N'-diacetylchitobiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30454" checksum="FF2D3AF46C1CE285" modified="2021-06-02" version="1">MKRGVVEAVTVVIAAVVAFPLYWMVLTALKPEAEVITADPRPWTLTPTLDSFTRALTVQSFGRYLVNSLVVALVVVLLSLLISFLAATALTRFRFRTRTTLLIMLLIVQMVPVEALTIPLFFMMKSVRDVVPVFGLNHLGSLVLVHLAFSLPFSIWMLRGFVAAVPVELEEAATLDGASRFRFLWQVLFPLVAPGLVATSVLAFIHAWNDFLFAKTFIISAAENQTLPLALQVFVKPDQNDWGAIMAGSTLMTIPVLLFFIVVQRRLVAGLAGAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V7</accession>
    <name>A0A7W7T9V7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NitT/TauT family transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27261" checksum="705CC7BABA024B67" modified="2021-06-02" version="1">MTATLATAKNAAVTLSGVRKVFGHGTSAVLALDGVDLQVEPGEFVCLLGASGCGKSTLLNIVAGLDAPTSGDLELTTSRPAVMFQEAALMPWLTAERNVELPLRLAGVKRGERKEKAGELLSLVRLVGAGHKRPHELSGGMRQRVALARALASTLGSAKEGTPGLLLMDEPFAALDAITRDVLQAELVRVWRETQTAIVFVTHDVREAVRLGQRVVLLSSRPGRVVREWNTAEGDEVALIDEITTHLREVISGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA23</accession>
    <name>A0A7W7TA23_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10576" checksum="6AB21D9246AB939E" modified="2021-06-02" version="1">MDRTGQKTALRRFLALVVFAFFAYWSVILAGLLGWSTTPRGPHRLTGHWHLPLLAIGAGVLGVALASRILGRRVLSPWLLLAVLPAAYFILVETGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA30</accession>
    <name>A0A7W7TA30_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RND superfamily putative drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="52"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="464"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="700" mass="73409" checksum="2C7816115283C665" modified="2021-06-02" version="1">MFAKWGALAYRRRWVVLIATVVLAVAGGVWGLGVFDRLSQGGYDAPGSEAARATKTVQDTFGRQGGDVIVVYDTADQAKLKEVGDRLADLPDDVVAPAQLVPQPAAGKTLAILTLRDGDSNGQIKQYEQIKDRLAVPGVDHLVGGLVPTQKEINDMSSSDLASAEVVSMPIVLLLLVVIFGGLVAASLPVIVGGLAILGSLGVLHVISLGLEVNSFAVNVASLLGLGMAIDYGLFMVGRFREELAAGRTSADAVRRTVMSAGRTVVFSATLLVIALAGLLLFPHGFLKSLAYGGMSAVAIAAVVSLTLLPALLGVLGHRVDKLSVPWRRKDRQPSERGWRRLAAVVMKRPVLFALPIVAVLVALGAPFLNVKFGEITEKVLPEGNQVRVAAETINRDFAGMTNNGFKVVITGDPTPAEVQAFATRIGEVSGVGEAKPGAEPKNGVWLLNASLDQAPLSEKSKEALREVRALDGPGTEVLVGGSTAVVTDSVDAISDRLPLMAGLLIGATFVLMFLAFGSVLLPIKAVVMSALSLSATFGVLVWVFQEGHGASLLGVTPGPLESGIVVLMAAMVFGLSTDYEVFLLSRMVEARGRGASTEEAVATGLAKTGRVITAAALLLIVVTGAFAFSRIAMMRFVGVGMILALALDATVVRVLLVPAVLKLLGNAVWWAPGPLRRIQERLAIHEEAPVEDEPVPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA50</accession>
    <name>A0A7W7TA50_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.343</ecNumber>
            <ecNumber evidence="4">1.1.1.44</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.343" evidence="4"/>
    <dbReference type="EC" id="1.1.1.44" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="162"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32370" checksum="76F381124B3B79E9" modified="2021-06-02" version="1">MQLGLVGLGKMGFNMRERIRRAGHEVVGYDRNPEVTDTASLAELVDRLEAPRVVWVMVPSGDITRNTITELSGLLSAGDLVIEGGNSRFTDDKVNADLLGEKGIRYVDAGVSGGVWGLENGYGLMVGGAAEDVELAQPIFDALRPEGPREEGFAHAGPVGAGHFAKMVHNGIEYGLMQAYAEGFELLAASDLVENVPETIKAWQRGTVVRSWLLDLLVRALDSDPELDDLRGHVEDSGEGRWTVEEAINHAVPAPVISAALFARFASRQPDSPAMRAVAALRNQFGGHSVVSAGPSSGTGSTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA53</accession>
    <name>A0A7W7TA53_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative PurR-regulated permease PerM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="383" mass="39616" checksum="2C8156C5C4632E82" modified="2021-06-02" version="1">MSGIDSESSARVPRLLRVSAALSWRFVAVVAALYVVAQVVGFLATIMIPAGIALLLAALLSPAVSQLTRVGVPRGLATGLVLVGGLAVVGGVLTFVITEFSKGLPDLQTQVSTSLDTIQTWLKHGPLHLSDVQLQQYLDKVLQTIKDNQAEITSGALTTAATVGELLTGFILALFTLIFFLHDGDGIWRFIIRIVPGDVRDRADVAGRRGFASLVSYVRATAAVAVVDAVGVGIGLWAVGVPLIVPLSALVFLGAFIPIVGAVITGAVAVLIALVANGPVAGLVVLGVLIGVMQLESHVLQPLLLGRAVKLHPLAVVLAITAGLVVGGISGALLSVPLLAVLNSGIRSLLSDSDKEVEPKDVDVHEPQETGPKDTGGERVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA68</accession>
    <name>A0A7W7TA68_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RsiW-degrading membrane proteinase PrsW (M82 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="388" mass="41328" checksum="74909F3780839DB5" modified="2021-06-02" version="1">MTDTRPRFDRRRITVLLPVLFLIVLGVCGIVLFSLGTSKIGLGPILVGAVAALLPVAAVIGTCLWVDRWEPEPAKMLLFAFAWGACGATITSLVFNQTAHVLGDLINGDGATFAAVLGAPIVEEATKAAFVLVLYLRRRDEFDGVVDGIVYAGVTAAGFAFTENIYYFARVFSVSGFGDLSNGVVALFILRGVLSPFAHPLFTSLTGIGIGIAATLDRRGIRIAAPILGYLGAAGLHSLWNFSTTVGTGSTFINLYFLIMVPVFAAMVALVVWQRRREQRIVAGQLPGMAQERWIAASEVSLLASLQGRRAWRRRVKRKVGDQAARAVAGYQVAATELAFLRHRIAAGTAGADADQRHERLLAALVAARKAAVEAPGALKAAGGVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB6</accession>
    <name>A0A7W7TAB6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13086" checksum="B6C6F83A20101A66" modified="2021-06-02" version="1">MGILVHVVLTAVAVWISTVIPGIDLEGASVPGKIGTLVGVALLFGLVNAVVKPVVKFFGCVFYLVTLGLIGLVVNGLLFWLTGWLAGELGLPFTVTGFWPAFFGALVVALTSWVLNLVYDRIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAV2</accession>
    <name>A0A7W7TAV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch endonuclease Vsr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the Vsr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00221">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004603">
        <property type="entry name" value="DNA_mismatch_endonuc_vsr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03852">
        <property type="entry name" value="Vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00632">
        <property type="entry name" value="vsr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18366" checksum="F781925D75BCAE09" modified="2021-06-02" version="1">MAESWASSPASRAVMRANRGRDTRPEKALRSALHAHGLRYRVNMRPIKDVRRTADVVFTRLKVAVFMDGCYWHGCPEHYRPAHGRTATFWQEKIAANKVRDADTDRRLSEAGWTVVRVWEHEDTAVAAAHVVGLLAGKRGDPSPGQDDGTPRPTGQPTPVPPIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB19</accession>
    <name>A0A7W7TB19_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">F4559_006686</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="20">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="19">
        <location>
            <begin position="246"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="428"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="MBB4969327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="543" mass="54715" checksum="F54122A4BD9CEC98" modified="2021-06-02" version="1">MSSTRLSGVGVSSGRASGPVVRVAEPLGEPPAGPAPSDPAAEAARIEPAAAKVADNLFARAAKAEGEAKAVLETTAAMAADPSLLSQAAKLVESDNLPAARAVHQAAAGFIKALEAAGGYMAERARDVQDVRDRLVAELLGLPAPGVPELASPSVLVARDLAPADTAGLDPAKVLALVTEEGGPTSHTAILARSLGIPAVVAVRGLLAADVAALEVDGTTGEVVESDGTVRAADTGAKVEWNGVGVLRDGLRVKVVGNVGSPADATAAAERGAEGVGLFRTEFCFLSASTEPTVEEQRAAYAAVLKPFAGKPVVVRTLDAGADKPLSFLDPEPEPNPALGVRGLRVAVDRPEVLDRQLAAIALAAVDSGAEVSVMAPMVATAAEAAWFVSRARAAGIARAGVMIEIPAAALTAREILAEVDFVSLGTNDLAQYVFAADRQVGAVAALNDPWQPALLRLIALVGEAGTQTGKPVGVCGEAAADPLLATVLVGLGVTSLSMNHTSLAAVGAKLAETSFDVCQLAARSALNAHDPAAARLAARAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCK1</accession>
    <name>A0A7W7TCK1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane associated rhomboid family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006629</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="126"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="30904" checksum="D50BB06B30D78518" modified="2021-06-02" version="1">MATPPNHPRPGDPVEASLPPCSRHPDRATGLRCTRCERPACPECLREAAVGYQCVDCVADGRRSVRRPVTFVGAEFDPRPRVTQALIAVNVLLFAGSALLAGSVARNDLSEPYQQLDLLPVAVMLGEWWRLLTSGFLHLGVTHLALNMLSLYILGRDLEPAFGRVRFLALYLTSLLGGSVAVYLFGKLNVPVVGASGAVYGLMGAMLVAVLRLKLNLVPALSVVGLNLVLSVTLPDISLLGHLGGLVIGAAVTAGFVYAPAADRARWQTLAVGGAVVLLLVMTAVRTAQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WSZ4</accession>
    <name>A0A7W7WSZ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6209" checksum="C545917A8364B896" modified="2021-06-02" version="1">MSSNNRQSSALVAPRATDKRARWTWSSETRDGSAPLRGAGTPPAPGLDIVSSWFHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT28</accession>
    <name>A0A7W7WT28_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
            <ecNumber evidence="9">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_000180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0874">Quinone</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="11">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4962821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="825" mass="87745" checksum="81B6C0779B30A3E8" modified="2021-06-02" version="1">MTIAPDKSTELVVPEGHVKLVIDGLEVVAPKGELLIRTAERLGIVVPRFCDHPLLDPAGACRQCLVEVEMGGRPMPKPQASCTMTVADGMVVKTQLSSPVADKAQQGVMELLLINHPLDCPICDKGGECPLQNQAMKHGRADSRFHEHKRTFPKPIAVSAQVLLDRERCVLCQRCTRFSKEIAGDHHFLDLLERGAQQQIGTAETARIEGAEADRNQSYFSGNTIQICPVGALTSAAYRFRARPFDLVSTPGVCEHCSSGCAERTDWRRGKVQRKLAADDPEVNEEWLCDKGRFAFRHVTSTDRITRPLIRDEATGELRDASWTEALRHAAEGLAKARDGKGVGVLAGGRLTVEDAYAYSKFARIAVRTNDVDFRARPHSDEETAFLTAEVLGRTPETGGVTFRGIEQAPAALLVAFEPEEEAPIVFLRLRKAARRNRTRVYHVGQFTTPAVEKTFGTLLACVPGGEPAALNALPEHASDVVEDLAKPGSVILVGERAAEVPGLFSAVSALAARTGARVAWIPRRAGERGALEAGLLPTLLPGGRLVTDADARAHVERTWGLAEGALPATPGRDSTGILTTAASGGLDALVVGGVDPYDLPDPGLALRALELAGFVVSLEQRHSAVTEHADVVLPVAPAVEKAGSFLNWEGRRRTFGTTLEGTGTLPDSRVLDTLAVEMDADLFTQTPAAAWADFERLGSAPAAATAPSVVAPLPTPPRAGQAVLATWRRLLDNGTLQADEPHLAATARALVAKLSVATAEHLGVELGGDIVVSTDRGGVTLPVEAADLPDGVVWLPANSGEVTVRRTLVAGHGSVVAVSRGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTH1</accession>
    <name>A0A7W7WTH1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="35" mass="3587" checksum="53AB2FF8CE0508CA" modified="2021-06-02" version="1">MSVARGATSAEDCRLLLDMLGLSPGEDGGSPPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT5</accession>
    <name>A0A7W7WTT5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="353" mass="38541" checksum="D5B025346E4B2941" modified="2021-06-02" version="1">MASLTPEVLRAAPKVLLHDHLDGGLRPSTVIELAEESGHQGLPTTDPEALGDWFRDNADSGSLVRYLEGFAHTCGVMQDEAALVRVASEAAQDLADDGVVYAEIRYAPELFTDKGLSLAQAVEAVQEGFRQGEAASGNRIRVGTLLCAMRQNDDWQRIADLVVRYRDAGVVGFDIAGPELGFPPTRELSAFEYLRRENAHFTIHAGEADGPESIHQAVQYAGAERLGHGVRLIEDVRGDEVGHLAAYVRDRRIALEMCPTSNVHTGAVASLAEHPIKRLDELGFRVTVNTDNRLMSRVSLSGEFGVLVDRFGFGLDDLRRFTVNAAKAAFLPLDDRRSIIQDIVEPGYAALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ1</accession>
    <name>A0A7W7WUJ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="30563" checksum="AE3774A1DA8FF3D3" modified="2021-06-02" version="1">MEELGDVAVFVRVVEAGSFSAAARVLWMPKSSVSRRVARLENRLGVRLLHRTTRSLALTDAGRAYHARVSVALAELDSAAGAAADSREAPRGVVRLAAPPDVGAEVLPELLAAFLARYPEVRVEVALSPSADLVEGGFDLALRGGAGGRGATRLQDTRFRLFASPVYLARKGNPQRPAELEGHLCLRFGDVDRWLLHGPRGEVSVAVTGPLAADDLSFVRRAAVAGAGIALLPEPSVAPAVRAGLLVPLLPDHHAEGRPLHLVVPSDRHLPSRVAVLRDYLVANFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN8</accession>
    <name>A0A7W7WUN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="38000" checksum="5F28BAC86AC20FEB" modified="2021-06-02" version="1">MTHANAPLTELGRLRLARCVVDEGWPLRRAAERFQVSPTTAARWADRYRELGEAGLVDRSSRPHRSPRRLPTRRERRIVKVRLARRWGPARIAHLLGLNPSTVHRVLRRFGLARLAHLDRATATPVRRYEHAAPGDLVHVDIKKLGNIPDGGGHKVHGRRAGGRNSSAHRDPTRPRKVHGRPNLGYAYLHNAVDDHSRLAYTEILPDETKDTAAAFWTRAQAFFREAGVTVRRVLTDNGSCYRSRLWRDTLANAGITHKRTRAYRPQTNGKVERFNRTLLDEWAYAQAYRSETERRETLPRWLHTYNHHRGHTALKGQPPASRVPNLTGQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR0</accession>
    <name>A0A7W7WUR0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsI (Penicillin-binding protein 3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="36"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="259"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="593" mass="64023" checksum="05405D53BE0E5C63" modified="2021-06-02" version="1">MLALLAAGVKLLYVQGVQADELSRLAQQQRATPIEIPAERGTITDRNGNQLAFSVEARALYAVPKRTRTNWDEERKNKPSMGSYDDRVQAIAKFIEQTLGTEVAGQKTDATTMAEKLGRDTTYIELVDNVDPAKAALITEKYFDVGAEYRAVRVYPNGTLASNIIGAANWRKDQQPAATHGLLGLENSQDNTLAGRYGKRIVDTMQGNDNVVIPGPGRSREVAAATPGKSIELTLDVDTQYAVQRLVTDYTAKSGARSGSAVVLDVHTGEILALANDKVFDPIDFGKATDDEKRNVAVSSVFEPGSVNKIVTAATAIEDGIYQPDSVLTVDPSIKIADRVVKDATYHPTQDMTFTGVFAKSSNVGTLMAAQKIGPDRYSDMLRLFGLGKRTQSGLPGEEPGYVPPRNQWSGSTFGNLPIGQGLSMTLLQMTGMYQTIANDGLRVPPRIIRAEIDENGARRETAHPEAVRVVSPKTAKTVRDMFRAVVQNSPGQTGTGPSAALPGYQIAGKTGTAQQTDEKCACYSTSAYWITFAGILPADDPRYVVGIMLDNPQGTQYSGSAAPLFHDIASYLAQRYRIPMSTEQSPVVPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR4</accession>
    <name>A0A7W7WUR4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">F4559_001725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7035" checksum="5C3EC96AF76756FE" modified="2021-06-02" version="1">MPKNKSHSGTGKRVKVTGSGKLVREKAGKRHLLEKKSSKLTRRLSGTTEVAKNDVPRLKKLLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU3</accession>
    <name>A0A7W7WUU3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030657919" evidence="7">
        <location>
            <begin position="25"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="750"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="285"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="485"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="733"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="832" mass="85600" checksum="631F1329CE651CC9" modified="2021-06-02" version="1">MLRTIIAGLKARTARLVLSSVAIALGVAFVTGTLVLGDAMNLSLREEFAKSARNVDVAVSLPDDSTLTGVPQGTVDAVRQAPGVEAADPRFFVQVPLIGGDGKARPAVAVPLATSDKLREYDLKEGRYPEGPNEIAVDTRTATAGKLSLGKPVSLLAEDDRRVELTVVGVYTQGAGSAQMSGIDHVVLEPAALTAFDPDALPYQVVAVAKAGVTQQQLADAVRTAVGADFQVLTGEQLTKKLLAQISSEAGEFTTLLLAFALIALVVASMVIYNTFTILVAQRTRELALMRCVGASRGQVFRGVLAEAVVMGLAASVIGLFGGLGVSALLQKVISGFADSDGDVLLPMSPTTVLAAFGVGVIVTVLAAVLPARKATRVAPIAALREQIDSGEEVSRTGLLRVLSAVVLAIVGAGVVVVGAGIKGESALFVTGGGTMVMLLAAVVIGPLVVGPVNRALGVLPRLVFGVPAKLASANAGRNPKRTSATTAALMIGVTIVAMITVVANSAKETANTQIDARFPADYTVTSSVGDRPLPQDLATKLEQVSEVEHVAPMTEVYGEDGYFTGVPRSALGDLVKPAVSGGSLDALGDGKIALNVEYAQQHNLAVGSTVEIKPRDGVATTLSVVALIKGQRLSDGMVTLETAARIMPDVDGYQSILVKLKPGVADGRAAVERVTSTSPLAVLDSAAETKAQLNTQLDQVLAFVWALIGLAVVIALFGIANTLTLSVLERTRESALLRALGLTRGQLRLMLVVESILMALMGAAVGLALGIGFGWLLTSALSSDTLKIDLIVPFGQIGVMLAAAVLAAVLAAALPARRAARTSIVGGMATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUZ3</accession>
    <name>A0A7W7WUZ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="897"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1856"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2881"/>
            <end position="2956"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3909"/>
            <end position="3983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1839"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="931"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1891"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2916"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="4376" mass="469493" checksum="2B7EE05D9B4A69F2" modified="2021-06-02" version="1">[encoded data, 4376 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV08</accession>
    <name>A0A7W7WV08_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase E1 component beta subunit</fullName>
            <ecNumber evidence="2">1.2.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="35561" checksum="9A053F2425B44166" modified="2021-06-02" version="1">MTVSMAGALNKALADALDADPTVLVFGEDVGPLGGVFRVTDGLAARFGDRRVFDTPLAESGIVGTAIGMAMNGLRPVVEMQFDAFAYPAFEQITSHLAKLRNRTRGAVSLPVVIRVPYGGGIGGVEHHCDSSEAYYTHTPGLRVVTPGTPDDAYRLLRAAIDSPDPVIFLEPKRRYWSKGPLTDESLAFDRAVVRRPGADVTLIAYGPMVATALETAEAAEEEGWDVEVVDLRSLAPFDDDTVCASVVKTGRAVVVHEASGFGGYGAEVVARVTERCFHHLHAPVLRVTGFDIPYPPPKLEEFHLPGVDRILDTIGRLQWDDEVVAARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV46</accession>
    <name>A0A7W7WV46_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MoxR-like ATPase</fullName>
            <ecNumber evidence="4">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="49"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="255"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="39771" checksum="4D5CB31C375A86AD" modified="2021-06-02" version="1">MSEPAAEAPNTPARDAQLLERTVFEVKRVIVGQDRLVERMLVGLLAKGHLLLEGVPGVAKTLAVETFATVVGGSFSRVQFTPDLVPADILGTRIYRQGSESFDVELGPVVANFVLADEINRAPAKVQSAMLEVMAERHVSIGGRTFPMPDPFLVLATQNPIENEGVYPLPEAQRDRFLFKIQVEYPTAEEEREIVYRMGVEAPVPTQVLSPEELVRLQGVASRVFVHHALVDYVVRLVIATRAPKEHQLTDVAGWVAYGASPRASLGIIAAARALALVRGRDYVLPQDVVDVVPDVLRHRLVLSYDALADGVPLDHIITRVLQTVPLPQVSARPTGPQQQAPQNQAPQQQPLSQQPPQQPAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA5</accession>
    <name>A0A7W7WVA5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Phosphatidylinositol phosphate synthase</fullName>
            <shortName evidence="10">PIP synthase</shortName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_002235</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61216"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
            <dbReference type="ChEBI" id="CHEBI:144472"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Contains a di-nuclear catalytic Mg(2+) center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00220"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02241">
        <property type="entry name" value="PIP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044268">
        <property type="entry name" value="PIP_synthase_PgsA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="CDP-DAG binding" evidence="10">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>a CDP-1,2-diacyl-sn-glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="20813" checksum="7443C48E0BA3E208" modified="2021-06-02" version="1">MLNIFARASVSRVTDPIGAWLLRRGLTPNTVTVLGTVGSVAAALWFLPRGELFTGAALVTAFVLFDLIDGAMARAQGGGTPFGAVLDATCDRIADGALFGAIAWWAFANGERALAAATLVTLVGALVTSYVKARAEASGLSADGGLAERAERFIVALVGVGLGGLGVPYILPVSLYLLAALVVVTVAQRIAAVHRSAKEYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA7</accession>
    <name>A0A7W7WVA7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_002086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="93"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="235"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="299"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="367"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4964727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="572" mass="61887" checksum="BB6C712DC53EB0B6" modified="2021-06-02" version="1">MIFSVWAPTPALVSLRVDGVDHPMSGSPDGWWRAEASGTDYAFVVDGTALPDPRSSWQPNGVHEASRVYDHSEFAWTDSGWAGRQLAGGIVYELHIGTFTPEGTFDGAAARLDHLVDLGVTHVEVMPVNAFDGVAGWGYDGVLWGAVHEPYGGPDGFKRFVDACHARGLAVLLDVVYNHLGPSGAYLDRFGPYFAGRNDWGPGLNLDGPGSDEVRRYVVDNAVAWLRDFHVDGLRLDAVHALVDRGAVHLLEQLAVEVEALSTGLGRPLTLIAESDLNDASLVTAREGGGTGLHAQWSDDLHHALHVALTGETAGYYPDFVGALAATLRGVFFHAGTWSSFRSRHHGRPVDTRRVPGHRFLAYLQNHDQIGNRATGDRLSATVPHGLLAVGAAIVLTSPYTPMIFMGEEWAASTPWQFFASFPDPGLAEAVRTGRRREFARHGWGEADVPDPIDPETVRRSTLRWDEPVEPGHADVLRMYRELIALRRSHPELADPRVDRFEVREVGTALVLHRGGLRVVCNLGAEPVDVELDGPCGEVLLSSAPVESGGRAMRVPAASFVVVGLGSQPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB4</accession>
    <name>A0A7W7WVB4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="19470" checksum="DBBA089E353915F5" modified="2021-06-02" version="1">MNRTLHLVVCAAPPALHVDSLVHRVHEAGWNVHLLATPTAATWLTTPARHEPGHPRDRSDPAPRADAVLVAPATFNTLNKWAAGIADNHALSVLAELLAADLPIVAAPCVKQALRDHPAYPRSTHTLTVAGVHLLDPDAVTTRTPEGQTTFDWELVAATLDDLTRTHEPRPHTTRRTVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW30</accession>
    <name>A0A7W7WW30_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="14" type="ORF">F4559_003333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4965974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="672" mass="70575" checksum="D90BD6770FCC9C96" modified="2021-06-02" version="1">MTTTAQRPPSTPPRVAAGTFDPRLLVRALPDALRKFHPRHQVRNPVMFVVWVGSSLVTVFAVGEPDVFTAAVALWLWATVLFANLAEAVAERRGRAQADSLRRARQDTVARLADGRTVPGTALEVGDRVVVAAGEVIPGDGDVVEGIATVDESAITGESAPVVRESGGDRSAVTGGSVVLSDRIVVEITARPGETFVDRMIALVEGARRRKTPNEIALTILLATLTIVFLLAVVALQPFAVHSGGEQSVIVLTALLVCLIPTTIGALLSAIGIAGMDRLVQRNVLAGSGRAVEAAGDVDTLLLDKTGTITWGNRRATELVPAAGVPLDRLVDAARLSSLADDTPEGRSVVELCAAEHGRRAEASEHEKTGVFVPFTAQTRMSGIDLDGRRVRKGAAGGFVVDDAVRAVVDDIGRQGGTPLVVAEDDVVLGVIRLSDVVKPGMRARFDRLRAMGIRTVMVTGDNPLTAKAIAAEAGVDDFLAEARPEDKLALIRREQEGGRLVAMTGDGTNDAPALAQADVGVAMNTGTSAAKEAGNMVDLDSDPTKLIEIVEIGKQLLITRGALTTFSVANDLAKYFAILPAMFATIHPQLGALDVMRLASPQSAILSAVVFNALVVVALIPLALRGVRYRPSGASALLRRNLLVYGLGGVVAPFAGIWSIDQLVRLIPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW35</accession>
    <name>A0A7W7WW35_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="54"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="222"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="474"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="560" mass="59825" checksum="EA154F6CA2903464" modified="2021-06-02" version="1">MSQPGDKNAGRLLGGLRLDDLLDEMRERLAEIASTRDKMQGLLDAVLAVGAGLELDSTLQRIVQAATELVGARYGALGVLGSKDDLSEFVYVGIDPTTRAKMGHLPEGKGLLGLLIKDPRAIRLHDLTKHDMSVGFPPGHPPMHSFLGVPVRVRDEVFGNLYMTEKTDGADFTADDEVVLTALAAAAGVAVENARLFERSRMRERWTEASAEINSDLLGGATAEDALRLIALRARELSAASLSLIVLVEDNGSRLRIAAGSGARGQDLVGDTLVRSGCVVAEVLDSATPMLVEDLEGRLGELPVELGPGVAVPLRVGPAVSGVLLAAREKGGVRFGADQVPLLASFADQAAVALEFAENQRARRLVDVLEDRERIARDLHDHVIQRLFATGMSLQGAVGAIVQPHVRERVERAVRELDQTVLEIRTSIFDLQAAQDLPGLRRRLLDLVAELTEDGSVSATVRMSGTVDNSVSDRIAEHAEAVVREGVTNAVRHARASGVTVTVEATDVLTITVADNGIGMPTQVARSGLRNLEARAEELGGTLTVDSADGTRLTWRVPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW90</accession>
    <name>A0A7W7WW90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid stabilization system protein ParE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10020" checksum="EA655002BE350682" modified="2021-06-02" version="1">MTYSLDIDPDAQDQIRALPPVALDALAEAFEVLSLVPERGRPLNPDNPDGGLFQLTFGDGRGLITYLLLTFQDRVDVLVVTWVSFEHPPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB9</accession>
    <name>A0A7W7WWB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA (YjgF/YER057c/UK114 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="13863" checksum="66D328F74599AB85" modified="2021-06-02" version="1">MTVTRINPPGLPQVEAYRQIAVATGSRTVYVAGQVAVEADGTLVAAGDLEGQVERCYLNIATALAGAGATFDDVAKVTIYIVDYTPDKLALYNAGVARAAEKLGVRPLAAGTLIGVTALASPDFLVEVDAVAVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWC0</accession>
    <name>A0A7W7WWC0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglut_core3" evidence="1">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="14939" checksum="189E255A2181AD26" modified="2021-06-02" version="1">MKARATALVKPAGNTFSGLPAAFSVLVAKVLGRQSPHRIRRVLTAVSRGARPATLAEAEAAHRAVLGSSVMMAGDGCLPRSIAVALLCRLRGRWPTWHVGAQIHPFRAHSWVVAEGVAVGETGDMSRWKSLITVGSQGDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ5</accession>
    <name>A0A7W7WWJ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031399223" evidence="1">
        <location>
            <begin position="31"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23246" checksum="83112C01C7C371C5" modified="2021-06-02" version="1">MRLRRAAAVVGALTTAFVSLGAVLVVPANAHGSMSDPASRIYRCFTEGPENPKSAACKAAVQVGQSWPLYDWDEVNIPNAAGKSRQIIPDGKLCSAGRDKYKGLDLARADWPATTLPGGGPFTLRYKVTAAHPGSWELYVTKPGYDPTKPLRWSDLEDTPFYKQTNPPVASGAYQLKANLPARTGRHVIYSIWQRHYPDSGEAFYSCSDVVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL9</accession>
    <name>A0A7W7WWL9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FtsP/CotA-like multicopper oxidase with cupredoxin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="443"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="628" mass="69232" checksum="766EE7186FA98333" modified="2021-06-02" version="1">MTETVDRSVSVAAGPTFGLEKFRDPLRIPPVIRPHLSWHQDTLNVTMIRTEVRLHSQLPPTTVWAYDGHFPGPTIDVRSGRRLRITWTNEIEGKIPLIGVQAPITSAPQNAPGFRNPDGTLPAGVTLIDGVADLPSWGVVHLHGARTGGGNDGWAHNALLKGDSQLAEYPNAQPATTLWYHDHAMAITRFNVAAGLAGMYLIRDREEASLRLPSGEHEIPLIIADRNLDTDADGDLTGQLLYKVPFLTTASGQVLHIPFSGPFTLVNGVIWPHLDVEARWYRFRVVNTSNARFYRLRLVDEDTGESLDRHVRQIGTDSGLLPRPAALPTGGLLMAPAERADLLIDFARLRGRRLKLTNAQPNAAPEPDIMQFRVEDRERRDRFRLPTTLSPSYVRLHHGTTVPDDHDHIFIALVPPGTGGEGHPGMWELVEVTDPERIPTTLPAPGILQITDPNSGRVRTFERVASLFDDTTSVFIDHDRWAVWNFLQLGGPAHPMHVHLARFQALTRTAYPIDPATGAAPGFDVAVGGTTTPLPVPGPGRALDPQEEGWKDTYVVGAGEWLTIAGRFDGATGNFMYHCHILDHEDEGMMRPFVVMPREAARFHVHRFGGGHHHGEVAEDTRSSGNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWW0</accession>
    <name>A0A7W7WWW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="719"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="765"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="810"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="856"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="895"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="941"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1031"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1238" mass="131415" checksum="6E0CD9567ADB2D50" modified="2021-06-02" version="1">MDSASIYQAGRDQYLVGRDLHMHYSETVRRARPVGPTSDECPYPGLTAFGPDQERWFFGRDHVVASVITAIDRSLREGGALLVVAPSGAGKSSLLRAGVLPALARGGLDGSTRWPCLVFTPTARPLEVLARYLATVVGIEPTRVLEVLRSGAEASREMVAEVVRRRDEHLVLIVDQLEEIFTLGVDDHTRRRFLDILTHLTEPHDGYVPAAVVFGLRADFYASCADHAGLRAAAQRDQLFLGPLSDDELRAAITLPARDVGLDVEPGLVELLLADLGTGVHEAAGGDTSGRLPLLAHALRATWQQRHGHVLTVAGYRTTGGIRQAVATTAEGLFTRLDPAGQDVARSLFLRMVTIGRAEDTRRGLPLTEFGGFGHDPRTVWAVADLFARGRLITHDHESAEITHEALLSAWPRLRSWIDNDRAGNLVRQELETAAAAWDRDGRDPSALYRGSRLETVRSMVDPGDLSTTAAAFLAASSAAHQRAVHRRGLVLAALVVLSLVASLTAVVAIRQNGLARDARDRAVADRRTAVFNQITAEADRVRVDDASLAARLDLAAYRMDPRPPLRTKLMSSQNTPLSSIVHRDDGNVRAVDFSADGKILATGGQSDTVRLWNTDDPSRTTPLGTIPIGRRDTVVSLAFAPDSRILAVAGDGGLVQLWNAADPAKPVRLGEIAGHLGTVSVARFSPDGRILATAADDSLIRLWDVRDAAAPLPLGAPITGHSGTVFGVAFSPDGRTLAGVDDDERLRLWDIADPAAPVALGEPQVGHKGPVLSVAFSPDGRTVATGGFDRTVRLWDVAAPAAPRQLGQLTGHTSFIWSLEFAPDGRTLATASYDHRVQLWNVGQPDRPASLGRALAGHTGPVTSLAFSPDGRTVATGGNDHTARLWHLPTTTVVTGHTDNVEAVASSPDGRVLATGGADRTVRLWNAADLDAVAPAGEPLTGFGGSVTAVAFSPDGMLLAVSAAEPVVRLWNVADPARPVPLGVLDGHTGTVWTVAFSPDGRALATGDAGGSLRLWNVTDPAHPAQAAEVRRQTGPVYGLAFTPDGRTVATASGDRTVQLWNVGSLPPTAAGTAGIGAFRHTAPLWAVAFSPDGRTMVSAGEDGSLRLWDVADPNAPAELSVVAGHTNTVFAARFSPDGRTLVSGGQDDAVRLWDVTDPRSPVSLGPPLTAHTGTVFGAVFGPDGRTLVTAGGDRVVRVWRTDVDRVVERICATTRDVLTAQRWAEYVPGTNQPDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX49</accession>
    <name>A0A7W7WX49_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="34439" checksum="BAF1CE21B162FB47" modified="2021-06-02" version="1">MISALEEARARRVAEGSNFKAYVTAGYVEGKTIRALAEATGRSYGTVRTTLVAEGIPLRRRGYRRTAAMMAAGDARARREELSSELLRARLARGMTGKSAGFQAGISQSKVSKMETGRLLPKVEDVERLADVYEVDTEMRVRLITLATRVARDAEHRRAVLHRGVSRQQVGVVKVASSASTIRVLGVSGVPRVLVEDISPRKQVIAILTEGALRGSPEAYEDAREAMERHNVDVRVVPFYGEVEVPESGFQIFDARMVVVDLLAGNVVITDEDDVKGHLERFATLYAHSVGGAELERILDEIDDECRDRFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX97</accession>
    <name>A0A7W7WX97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19651" checksum="BEBAB542AEEFF024" modified="2021-06-02" version="1">MPKDTKARAQEVARELFRRQGLRRTSLQEIADRLGITKPALYYHFSSRDDLVRSIVQPFVDDGDVFVDHVTAQPAITRRAVLEGYFDLHHRHREVMTLVLRELIELSELGLVNRVLAWRDRLRAVLVGPDASLADRTRATVALGGLTDCVLEFHDEDVAELRVVAVDAACAALGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF3</accession>
    <name>A0A7W7WXF3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8118" checksum="90A664383F68E03C" modified="2021-06-02" version="1">MSVVNGRNLDARIRALETRLKQVEGIQQIQVEKLVAQVEETHRGVTLILSMLARDPELAKLIPQSPSDGPSSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY02</accession>
    <name>A0A7W7WY02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA editing enzyme YbaK/EbsC (Cys-tRNA(Pro) deacylase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="38"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="170" mass="17443" checksum="11C8C2A9B782A10F" modified="2021-06-02" version="1">MSALQPDMRHPGIERVADALAEAGHHDSAEGIRVLADAVRTAAEAAAALGIEPGAIANSLLFRAEYAGQARPLLVLTSGAHRADVDLLIALTGADAIKRGTPEFVREHTGQVIGGVSPVGHPAPIDTLVDVDLEGYAAVWAAAGHPHAVYPTTFAGLVELTGGTPARVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY29</accession>
    <name>A0A7W7WY29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="456" mass="47701" checksum="0A7D2B4C0FD3396F" modified="2021-06-02" version="1">MTPPLPDGLVAALPCGRSEPGVVVRAARAARGWSQADLGRRCGYSASQVSRWETGRLPLRDVGLLRILADVLALPHAAFGLSDHDTPGARSRRPVAVGLRVGRATTSPDQEDDPVRRRALLAGFAALAGSALVRPGTAGADGVDPAQVLTRRLGDALLGPAPNGRAVPIATLTRALASARHEFSACRYLELADRLPTLLGHAEATAGVGAEPGVHRVLAAAYQLATRALIKLRVSGLEWLAADRAARAANLAADPLVRAESQRLLASVARRAGDHDRALALTLAAADDLVRTGREPARSAMVGSLYCSAGYAAARAGDRERARELLGQAGVATAVLVDHPGRHRAALTNLVSHQVSAAYLLGDAGAALAYAHSLPLAAVPTTERRARLLVDTALAYARWDKPDEACRALLTAERVAPGEVRTRNAVRLLVSDLMAAPRQAAMPGLSALARRVHLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY98</accession>
    <name>A0A7W7WY98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030882537" evidence="1">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22202" checksum="2DA94F698562B4FE" modified="2021-06-02" version="1">MRRVVAASLVVASVMACSSERRPGSSTGVPSANSAPTDGPAVFRSFTDANEGCAQLRYTPFEALFGQADLAPRVRGDGGDLGCDLDLVEGRYTGATIYTEVRFFADVEEAYADYRGHKQDGDRKAGEVVDVTRLRDRGHRFVNGPQVAARPGQLQFRAQRGNVGVTVRVDVLVETDLDSEARWSEVHDAVTDYVNTTFDDLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ18</accession>
    <name>A0A7W7WZ18_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg/Co/Ni transporter MgtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="354"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="45581" checksum="F73CC552E28284D2" modified="2021-06-02" version="1">MVVVNRVFAAQLAGLPVFGPDGESIGKVRDLVVGLRIDRQPPRVLGLVLELATRRRIFVPMLRVTTIEPNAVSLATGTVSLRQFHQRANEVLVVGELLDARVRMDSGAQAVLVDAAMEPTRTRDWRMTRVAVRERTGRLSRRGPVQVLAWEDLTGLSITELAGQPQGAQHLVALFETMRAADVALALHSLPSKRRYEVAEALDDERLADVIEEMAEEDQKDLLAHMDEERAADVLEAMNPDDAADLLAELPEPEKDRLLDLMEPEESAPVKRLLKYSYDTAGGLMTPEPVVLAPDATVAEALAHVRNPDLTPALASMVFVCRSPTATPTGRYLGCVHIQRLLREPPSDLVAGVLDTDMATLSPTASLGEVTRYFAAYNLVCGPVVDEAEHLLGAVTVDDVLDHLLPDNWRETGLTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ70</accession>
    <name>A0A7W7WZ70_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32647" checksum="D5598A2089E49D27" modified="2021-06-02" version="1">MRALRVIGLEDDGKTVVLEDPERGERFALPADERLRAAARGDLTRLGQIEIEVESQMRPREIQARIRAGESVDQVAVASGLPANRVERFAYPVLLERSRTAELAQRAHPVREDGPDVQTLGEVVAHSFGLRGQEYADVRWDSWRGEDGKWVVQLHWTAGRSDNRAHWAFHPGAHGGTVTALDDSAVELMDPNPNRPLRTVRPVTQLARQALQVEKAAEPEILVREEPAPPVLPPAPEPEPEPEPVVVAEEPTPEPTPAPAPAPRKEAAPPPKRGKKNHPIVPSWEDVLLGVRSNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE0</accession>
    <name>A0A7W7WZE0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031316134" evidence="2">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="20582" checksum="C3D4EE7D9E4840C5" modified="2021-06-02" version="1">MRSSAVRTTALLTAVAALTAACTTEQPGKGMAASPTSAAPKTTTTEKKPRPEEIKLDGIDPCQVLTDEQMKQLSVSRRTRMNQDLVKDGSEDPVCNYGNNSSPRIIYGVGLVIGSGIDHWTGNGNVDVKPTTVGGYSAVTLTFKGAPVDCALAIDIAGGQQFYFDYEPGQAAAQDVMCQNAVKGAELALATLQTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZM9</accession>
    <name>A0A7W7WZM9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="44669" checksum="526013AB212B3543" modified="2021-06-02" version="1">MRAPTLKVVDLFSGAGGMSLGFQAHRDFTVVGAADAQIGKPSSRLGSLRCNGTYRDNIGVDPLQVDLGRLDPAVLRQVWNLERGELDVLVACPPCSGFTRISPANHLRDDPRNSLVGRVAAYAAEFRPRVVLLENARELVGGKQRHHLENLAERLIEIGYEVDARKHMLSRFGLPQLRERAMVVAVDAGVPLRTLDDLWRNWEVREQALTVRRAIGRLPEVEAGLAHPDDPMHVSPSFRRDRSLDRMKAIPVDGGSWADLVNGNEGLLNPAQRKIIEAGKWGSHPDVYGRMWWDEPARTIKRECGHVGNGRYAHPDQHRLCTVREMALLQGFPQRFRFDVSVIGNAYRHLGDAVPPLISFQLATLVSWMLTGRHPSVKDLCLPGTSLRPGDIRPVVPADLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZP7</accession>
    <name>A0A7W7WZP7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="21244" checksum="B6B18E0757B77434" modified="2021-06-02" version="1">MSVPVPASPPASGPTDAPTAPSNPQDNPTPPTTPGIGEPQGEPAPPTGAADVESLRAEIAEWRGKAEGAQQGIVDKIAAALGIDKSGEAPTVEQVTEQLTAAQREARERAVDLAVYRAAPTAGADPDALLDSASFRRKVADLDPSAEKFGDQVAAAIAETVKAHPRLASAPAAAPRSGAEITGGSPTGSDDLGSLSIEDYIKRTRKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXM4</accession>
    <name>A0A7W7SXM4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YhaH (DUF805 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16870" checksum="D04B968C42531A74" modified="2021-06-02" version="1">MTSTEDSSPATLPVPTEVRAAYWIWIVVAVVSGASALFLPTQRAVLEQAIRESDFGRTLTPEQLDVVVTTNIVVPVVFYLLIAVLGAFFAFQARRGRNWARISLAALTVLSILYVFGNRSVIGLAVTFLAVVAVVLLFMGKPNAFYLAHKRPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY02</accession>
    <name>A0A7W7SY02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030643513" evidence="3">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8340" checksum="1AC930F638F09BAF" modified="2021-06-02" version="1">MRGRGAVLGLVLGTTSTLVVEGVAGAADGVVAAGSLSMNAPVGIGAVALGVLGLITGLVRRRKVKPEPTAQNRRVEPEPAANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY16</accession>
    <name>A0A7W7SY16_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="39543" checksum="50CBBBF75FA5EC41" modified="2021-06-02" version="1">MLRPYRELAAIPGLTALLCWALAGRLHLPTVPLAVAFLVVGWTDSYALAGVVGGAMTLGMGVASPLRGRAADRKPATPLLLATVSGYAVGITALGLVPVLLPASAWPVAVVVAFLVGVSTPPVTQLSRAGFQRLASGPTLNAVFTVEASTQELTYVIGPAAAAAVVAVASPEIALWGAGVTAVVGALGFLRALRRAGIDRPVPHERAHGGPALLRDRSLALSFLAAGAIVASLVSIDMVIVALARDGGVPALAGALAAVWGVGSVVGGLVTGGWTGPMRFARRMFAMSLGLLALVPVLPPVVGLSPWSVGVVLVIGGLTIAPTIAANNSRIGALAPEGRKAEAFGWMATFTTAGPALVLPWIGRLIDGPGPAAAAAAAGGLALLGTVAASAVHVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYC3</accession>
    <name>A0A7W7SYC3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="937" mass="94276" checksum="4A5E31A673BA8242" modified="2021-06-02" version="1">MADQNEIKQLLDDPNVTPETKKQLVRALAGSGGSEEDVRRYAEANGVEVPDDPGFWQHAGGVLLAPVTGGASVAYNVNEEMEHGAWTMEGGEADSLVNKAKEERELGSTQKVLNETGDVPTSDVLLDAGAPGLRFFEKFIPIYAEAAPVIGHNGQAPQLTEYIYRNYDEVSEIDFAKFREDAEKINKAAADLDNHENGLGTAWNALGAWEGDAANAANGYNGKFLNTAGTFIQNTKGAPGTITTAVGTMQQQVKEFAQHVHDMYSEQCGGLTVDQAKEAIRQAKGDVFENDGGILDWLAGVPGWLTGTVIGAICGGPLGILVGMGWSDWITDVRDRIIEDAKNKLRGLCQEFDGKKQAFDGYCQAVQTGVQGTYDTMFGQLDGQLTDKPFGQVGDPPSFTGEQGGRDKVDQPGGTSGTPGGTSGTPGGGGTPPGGGGTPPGGGGTPEVPKIENPLDKDGDGKPDVPGDTDGDGKPDDLDGDGKPDDPNAGKPDGLKGEEEPETVKIRSGENEITVTEPDENGHVKITVDTPTSEPKTYDVDFGKNPDALNALLGQNGAAPLTGTVPGGAAAGGTAPTPAGGPASAGDGSVPVQAGADGKALIELEGLSITAEVDPLTGEINLTVDDGDGTPEEYGVGFGADKADEKPGVPGDVTTLPAPDEGFRALPVDEGFHALPVDGPVDGGVGPSGATQEGSASGGFGSPDGVTQGSAVADGVVQGGPAPAEGATQGSAVSGGVGTPAQGSAVPPAWGVPVADVSAPVHGDQGAWTAPTGDRPAHGDHSFGGPAHAGVPGSGWAAPSFDGASNEGVTTASGASILGGNGGFDVADSVLGGSGTDTPWSGSAGDADLADTNASQAGEAGSATLPSMQDGPHQTTGTAGGGMMGGGMMGGGMAGGGQQQNGESERSPSQWRTSGSLFDDDMNLSRVQGVLGDEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR3</accession>
    <name>A0A7W7SYR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="110"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="29304" checksum="8F7155CDA75F368B" modified="2021-06-02" version="1">MTVPRSAIPRPRLEVERGAGYHRVRVVGLVAAAHAALTGGVLNRAVLRLLDRALPRRGVPAVRVSVSPGVNLRLHGGGALARMAVVGAGYEHAEGEVLTGATQPGGVFVDVGANVGWFSLLVGAHRPAGEVWAFEPIDDTARHLERAVVASDLRNVLVYRIALGEHDSDAEFLVTPDSAFSHRAADGGTSCPVRTLDGIWRAAGGPRVDCVKIAVEGDEPAVLRGAREMIACWRPLLLVDTPTSERRAAVLAEVAGLGYREQECSGLLPYNTVLTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV9</accession>
    <name>A0A7W7SYV9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="43783" checksum="1A02AA7B04EF4899" modified="2021-06-02" version="1">MGDGVMTGFNSDWQNPDNFAGAGPVETFFQTLDAFSRVDEADFAELGMNAAAFGLDLLGTLIDPLGSLATAGIGWLIEHLSFLREPLDWLAGNGDKIKAAVGQWNKAAAELDRVAQAQHDAISTQVAGWEQGAADKFRASQGQLVGETLGMSRTCLAVAEKIATAGTVTAAIRGMIRDLIAMFVWEVIRNAVIALASSWITLGGSLAAFAAWAVGRGAVVLGKVTAQIAKLMRFITRLMGKIKGLFGSLGDMLRNLTRFGKGARGTTRAANAPSTPRFQGMDDAAKRMEDWGNARPTRADVGTEVKQAGREFGDAYKNAGETWARKTEGVTYRPAHRGSDIADGYTPFKPPTRADGTAAPHSVPSLGDGAFVTKLTADLAREASKQDELQNEGVPKGQQPTFKRQTGYLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW8</accession>
    <name>A0A7W7SYW8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-carbamoyl-L-amino-acid hydrolase</fullName>
            <ecNumber evidence="4">3.5.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.87" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050538">
        <property type="term" value="F:N-carbamoyl-L-amino-acid hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>allantoate</name>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001235-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="41053" checksum="2736D550B1F54C46" modified="2021-06-02" version="1">MTGLADIADVGRDPRRGGYSRHGFDRSELELRAWFTEEAQRRGLDVTVDRNGNLWAWWGTPGPDAVVTGSHLDSVPGGGAFDGPLGVVASLRAVDVLRAKGFVPRRPFAVVVFVEEEGGRFGVACLGSRLLTGAIAPEAAARLTDQDGVSFGEAALAAGVDPLRFGRDEEALRHIGVFVELHVEQGRGLTVPVGLASSILAHGRWRFTFSGEGNHAGATLMTDRRDPMVPASQVVLAARRAATDGARATVGRLVPNPGGTNVIPSSVDLWLDARAADDARTRAVVERISQAAKDAAEEEGCAVRITEESYGDTVHFSPSLRDEIAGVLGDVPVLPTGAGHDAGILAAHRPTAMLFVRNPTGVSHAPEEFASDEDCAAGVVALAATLERLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ75</accession>
    <name>A0A7W7SZ75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Simple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="421" mass="44241" checksum="BD44FC6520E3A048" modified="2021-06-02" version="1">MSTSLMNPSEAPTTVPPPRKKRVPGWLVGVLGVAGAVVLLSTTSYLTDVPQLTSSGTTQTAVRLALPILLAGLGGLWAERAGVVNIGLEGMMIMGTWGAAWAGYQWGPWAALLSAAAFGALGGLLHAIATVTFGVNHIVSGVAINLLGAGLTKYLSTLIFFPISHNPRESPAVPKFDTYSASSSLSDWLAELENAQRVGISDVAGILRGLVTGVSPLTILAVLLVVFTYYFLWRTRFGLRLRSCGENPVAAESLGVDVYRYKYFAVLASGALAGIGGAALVLNPGQPGYLEGQTNGRGFIGLAAMIFGNWRPGGLLGGAALFGYADGLQLRSGGKTFLALIYGAVLLLGVIVIWQLVRRRWFAAAFGIVAAVALYAVYYSVDEVPSELTTYAPHLVTLVVLAVASQRLRMPAADGVVYRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ79</accession>
    <name>A0A7W7SZ79_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="27259" checksum="AA8720A95B7506E3" modified="2021-06-02" version="1">MAEFVRLDVEDGIGTIRLERPPMNALNRQLQEEIRAAALEAAARADVWSVIVYGGPKVFAAGADIKEMADLTYAEMAERAGAFSSALRAVAEIPKPTVAAITGYALGGGFELALCADRRIAGDNAKVGQPEILLGVIPGMGGTQRLPRLIGVSRAKDLIYTGRFVGAEEALRIGMVDEVVAPDEVYAAAKRWAGQFVDGPVRAYAAAKAAIDGGLDTDLGNGLKLESQLFAAMFATEDQKAGMASFIENGPGKAKFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ89</accession>
    <name>A0A7W7SZ89_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="27513" checksum="30190DE96279B9A7" modified="2021-06-02" version="1">MNIVVLVKQVPDTWSERKLVDSDHTLDRDAADAVLDEINERAVEEALVLRETHDGKVTVLALGPDRATDAIRKALSMGADEAVHVSDEALRGSDALTTARVLAKALGTVDGGFDLVVAGNEATDGRAGAVPAILAELLGLPQLTQVRKVVVEGTTVRAERETDEGIAFLEATLPAVVSVTEKINEPRYPSFKGIMAAKKKKVTTLTVADLGIDAGQVGLGAAGSRVLEAAPKPPRSAGQRVEDEGEGGRRIAEYLVGQKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF2</accession>
    <name>A0A7W7SZF2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="453" mass="46520" checksum="04E40D3F1E42CD25" modified="2021-06-02" version="1">MKTTSTPSRLWSPERRGPTAGIVLLVTLLAFENMGVNTAMPRMVASLDGNDLYAWPFLAFLAASVVATVLSGRLSDVRGPRPSLILGPAVFLVGLLVAGTAQDMGMLLLGRVLQGLGGGAQVVAAYVLIGLVYPESDRPAVFGVLSSAWVVPSLVGPALSGWLTETVGWRWVFLGLAPFVLVAVLLITPVLRGLPAHTPDQGTRRGLPLAALAAGVGVSALSWAAQHPNGLNLVAGLAGLAILVPALRVLLPKGTLSARRGLPFTILARGLLAGSFFGAEAFLPLTLTSVHGYSAVAAGLPLTISALGWSGASLWQARRPDIPREKLVRAGFVLNAVGIAGVTLVAPSWGPAWATPVLWLVAGAGMGMAMSSLSVLTLGASTDADRGFNSSALQMSDMLTAALLVGLGGVMIDLIASAEHPTAAVVPFDLAMVAVSLVGAVLAGRLRRATLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL7</accession>
    <name>A0A7W7SZL7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12861" checksum="6C65A357AF62E9D3" modified="2021-06-02" version="1">MNEYPYATCTRSIPSWVMFGVERPGHVVLFASNELTQAELRSHVLGEPLLWESSPVEWEYVLTTTTSSFVKILAPDWPAAFKGPFARWSPDAQNRDTTNPAGLLGHDMAQAQLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN0</accession>
    <name>A0A7W7SZN0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="508" mass="53812" checksum="2F8F8EE9ACE4ECCA" modified="2021-06-02" version="1">MTEAGQVLDIPFADAFAFDPSPTWAAIRESDRPVVRVRTLTGSHVWLATRYDHVRLILSDPRFSRAAVVADGAPRAGVSRPLSNTLPTTDPPEHTRLRRLVSGVFAPRRVEALRPAIRELAGRLADDVAAAGQGADLRQLFALPLPIQVICSMLGVPYADREAFREWTELAYSMEVSERARVESAMGSLVGYMTDLVVRKRIAYRRGAHGSVAVAGAATKASHDADAVTARGGDTDAVTNTVTNAVTDTDAVADADTGVVGNTATDGVAADDTVAATGTVTTAVAGTDTVGTAVADTDAVESAVAGGIRDSAHDHAEDTGGDLLDELCRTALTDDELVAFALNLLVAGHETSANQITSFVATLLRDPALWDRLVRDPGLLPSAVEELMRVTRLSDVGQLRIAKQDVELGGVTVRAGEGVMASIGAANRDPRVFPDPDTVRLDRAPNPHLALGVGIHFCLGAQLARIELGEALSVLINRFPRLRPARPIEDLAWRRVLVSGLAELPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT2</accession>
    <name>A0A7W7SZT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20544" checksum="C5ACBB0E1ABCB322" modified="2021-06-02" version="1">MAARPGGRSERVRASVIDATFAELVERGYLGMSVENVANRAGVHKTTVYRRWGTVEGLVADALDHTRDTPWPVPDTGTLVGDLTAIAYEVVDSFADPVRRTVPVAVVAAALMSSAATRAKNDFYGARTAEAAQVVTRAVERGELPATTDAAEVIRLVCGPLYHRVFITGDPIDHGVADRVVRVVVHAAKAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT3</accession>
    <name>A0A7W7SZT3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="207"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="547" mass="59260" checksum="4D111E963218A499" modified="2021-06-02" version="1">MTFVLEHLRAEMPDLREAPATFVRMHVERLRTATRMRVLREVLGVLVIVGLDVWPGWIADDLGAGGWASAGIGAAFIALYLSRLLFPALSLLVGTWLVFFADCGGISLVIMLAYAAGYRIVTWQRALQTATFALALYILVWEWSAPGLSGPLNSWVMLTVYCMVIVLPFLIGRYAAQRNALVAALQEREERVDRERRMVTRQVRLRERNRIAQDMHDSLGHRLSLISVHAGALTLDPELSERQREAVMVLRGAALTAMEELRGVIGVLRRDLPEDDEGGRRTVDAIDELVDGARQAGVRVSLVRGGSAVPLPAKVSHAAYRIAQEGLTNASKHAPGAGVQVTVKYEPDALVVEVRNNPSRSRPPAASSGFGLIGLGERVRLAGGMLHVGDTPAGGFRIAAVLPYEDTAAADADEPADEAPRGARNRTDRVRQWAGVGSILLAGVVVVVVVGGYTWLGAQPVSKVVNRDLYDSVTVGQSEADVMGRLPGGVDPPLGDLRSQAPPEPEGAKCVYRVADEQTFTARGAKVVRFCFADGKLIEKNTHLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU7</accession>
    <name>A0A7W7SZU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29103" checksum="5CA75FC828879ED0" modified="2021-06-02" version="1">MKGLVRAAWAAVRSAEVLPSPNIWHWPEVYEVENRAQDVDGEIWARLRSTYDWAGRDVVDVGCGDGFHLPYFARDARGVVGVEPHPPLVERARARVADVANARVLTGGAQRLPLPDACADLVHARTAYFFGPGCEPGIREADRVLRPGGVLAIVDLDGLAEPYGPWLCADEPRYDPRVVEAFFDTEGFTLTRVRALWRFERRAELESVLRIEFSSKVAERAIARTPGLSFEVGYRVHTRVKPTGLLRGQSSVSSSTSISPRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX2</accession>
    <name>A0A7W7SZX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25159" checksum="40E9E09007602A5E" modified="2021-06-02" version="1">MRVMGVTPGSVAVGDFVVDGSTVVLTPLGPRAPDVDLVCAPDPVPCTFDVLWLRASGHANAVALDVDEFVRVTRVSHDRCSVHSTGTGTVLANVAMSVLTNGRRTGDLRGEFASRGHVDDTLLARLLADRWGHDRAYLDSVTNGLVVRAEHLFATLVEFTARTAAQGCAGADIVIAAGSGMRDPALVRALTRHVPLRMSDEFGVPTGHKRGYAAALHGFLTRTATTATGLSVGGHRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ9</accession>
    <name>A0A7W7SZZ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="415" mass="41801" checksum="69CDF83E40B77271" modified="2021-06-02" version="1">MALWTVHGDGRATASGSVAPGERLSWPLTVGFGAQHLAAMIGATILVPAATGLPVTTTLLFSGIGTLLFLVVTRNRVPGYLGASFAFIAPLAAVRGEGIPAQLGGVVAAGLLVVIIGIAVKALGVRLLESVMPPVVTGAVILLIGLNLSHTATVSFAQQPMLAVVTAGVVVVCGVVGRAMWFRFSVVIGIVVGWLLGAALGVLDTRGIDRAAWFGLPELHTPELRPSVTLVVLPVVLVLVTETVGHVKAVAALTGGNLDGNVGDSIIATGLSTTFAGLAGGAGTSTTSQNVGVMGATRVYSTASYAVTGLAAVLLSFSPKVVAVFGTVPPGVLGGATVILFGVLALVGVRVWLDHRIDLTNPANLLVVGTAVVVGVGDLTLEIGALRIGGLVWGSLLVVVLYPVVRGLRVSGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T051</accession>
    <name>A0A7W7T051_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24552" checksum="8CFC995AA40352EA" modified="2021-06-02" version="1">MNRVEELAANLAEVRERIDKACASAERDPAGVELLAVTKTFPASDVALLCDLGLSRFAENRDQEAGPKSRELAEARPDADVRWHMVGSVQRNKARSVVGWAHRVDSVDSTRLADALARAATAPLEVLIQVSVDGDPKRGGVPFDGLAELAAHVARTDELVLRGVMTVAPLGTHPGQAFAALEQAVTRLRDDHPDATVISAGMSGDLEDAIAHGSTCVRVGTALLGSRRLASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0B6</accession>
    <name>A0A7W7T0B6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="6" type="ORF">F4559_001315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20559" checksum="FA4F1710297CA567" modified="2021-06-02" version="1">MIDETLLEAEEKMEKAVSVAKEDLSSVRTGRAAPSMFSRIVVDYYGSPTPLNQLASISVPEPRMAVVKPYDASQLNAVEKAIRDSDLGVNPGNDGSVIRVVFPQLTEERRREMVKVAKSKGEDARVSIRGVRRKAKETLDRLVKDGEAGEDEVARAEKELENVTGRYVHQVDELVKHKEAELLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E0</accession>
    <name>A0A7W7T0E0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32342" checksum="2416446DA3B789E0" modified="2021-06-02" version="1">MIVTGDTLGIGDLARLTGVPVRTIRFYCDEGVLESVRSVGGHRRFGRDTVERLDLVRRLRRLGLGLPAITSVITGRLGLADAVAAERVAVDEELAALAWRRAALRAVEEATPVDRAARLDLLAAAQDGRAAHGALTAFWHRHLTGPVPGETLSMFLDVTAPPPPADPTAAQVVAYAELVAMVADRSPLYRLLEDARGHFHDILDQAALQEGVGAACLEALPLVAAGVPPGRGPALDAFVAAHAAVRGRRDSRVFRSGLLASMAVDRGPRMRRYWSRVRVVTGGTVTLGETHAWLQDSLASSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E2</accession>
    <name>A0A7W7T0E2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-keto-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047434">
        <property type="term" value="F:indolepyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="206"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="414"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="594" mass="64595" checksum="B33F698AF3ED1E76" modified="2021-06-02" version="1">MTTTVARYLASRLASLGIEHVFGVPGNHLGPFLTAVGHTPGIEWIGTPTEVGAGYAADAYARVRPGPRIGAAAVTYSVGAFTLLNPIGGSYVEYVPVVAINATPTYEQWLNYRAIGLLTSHMSQRRESNLDVYRQVTVDAQVVTNAALAPVQIDAALVACLSERRPVYLEVMEDVWDAPCASPVGDLTARTRPVTARNEQVLGRAVDAAVALIEELGRPILWAGEEVDRFDLAGPFGELVEATGIPFCTTIGGKAVLSEDHPYFVGVYNGKSSTPWVYTVFQKWARVRIGIGSWSTSKNLGGERSIGPDWIVAAHDGVSVGASYFPDVRLPAFVEALRDRLVTRFGERHFEADYYARAHEAGLPVPSAYRSTRAVAAGTGLTYDLLFDRVNDLLAASPRTYTVVSDAGFSLLGSMSLHVSEKDGYLAQNSWLSIGYSVGAATGVALVRQDRRPLVFVGDGSFQEVVQELSTHVRHGLRPVIFVLDNEGFYGIEQMLVAPCYYTKPPSSEPDYYNILHPWRYDALAQVFGTATAPMTGVEVASEEDLADLLRRLGDRADSVNYGPVLVHVRLRRDDYPVSISYKVEECAQPEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L2</accession>
    <name>A0A7W7T0L2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="9" type="ORF">F4559_001748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="46244" checksum="B49B663DE091A767" modified="2021-06-02" version="1">MSEHILDELAWRGLIAHSTDLDALRRDLDSGPLTLYSGFDPTAPSLHAGNLVPLLMLRRFQRAGHRPIVLAGGATGMIGDPRDSAERALNTLDTVAEWAGRIRGQLERFVEFDDGPTGAVVVNNLDWTGGVSVLEFLRDVGKHFSINVMLGRETVKRRLEGDGMSYTEFSYLLLQSNDYLQLNRQFGTALQVGGSDQWGNIVGGVDLIRKVEGRSVHALTAPLVTDAEGRKFGKSTGGGNVWLDPTMTSPYAWYQYFVNVGDADVLRYLKLFTFLSREEIADLAEQTTSAPHLRAAQKKLAEEFTTLVHGEHETRQVVAASQALFGRGELRELDLSTLAAAMAEAPTGDARLADAPTIVDLLVASGLSDSRGAARRAVKEGGAYVNNVKIADEEWVPAQEDLLHGTWLVVRRGKRTTAGVRIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V7</accession>
    <name>A0A7W7T0V7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="24437" checksum="3C71A613D9DD98C7" modified="2021-06-02" version="1">MTDLVAPVGSSHEVWTGSGIADSIEGLVDAIKSDGWVDDLLAGTGAAVEVAAFALDPINGLLSNGLGWAIEYFEPLREMLDELTGKPDVVRSHVTTWENMAKELYGMSEDLKSCVEADIPDWHGAAADAYRAKMAKNVEAIGALGAISAAMAVATEGAGNLVEMTREIVRDLIADLVARVIVWAVEAIFVVTIPLIASQIVAAVVKWAGRILTYTMALINSLTSLTKLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K3</accession>
    <name>A0A7W7T1K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030970288" evidence="1">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="15378" checksum="82853956A92A79E8" modified="2021-06-02" version="1">MSPHRTRGFLRTTLLLALGASPLIVGVASATETLHAPVEPRSGDAGRVDAVRADVPVDRPVVLPVPADVPVLDGAAGPAPMPGIYEGEPRTPMARDRIAPALPGVPGVADSGIRVPDVADLPAAPAVPALPGLPALPAAPAVPGDLGTGLPALGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y3</accession>
    <name>A0A7W7T1Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27486" checksum="A1BCA42BE08A677F" modified="2021-06-02" version="1">MGGFEDLVAEADAADVTGWDFSWLDGRATEDRPPWGYQRLMGERVGRADVSLDLQTGGGEVLAGIPQRAAKAMVATESWPPNLAVAQENLRDKGVVVVADAGGPVLPFADGTFDLVTSRHPVGVHWAAIARVLAPGGTYFSQQVGPDSGHEVYDFFLGPRPPGESGREADLARAGAEAAGLEVVDLRTAELRMEFFDVGAVVYFLRKVIWFVPDFTVERYRDRLRELHERIRADGSFVAWSRRFLIEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y5</accession>
    <name>A0A7W7T1Y5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding LytR/AlgR family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="4">
        <location>
            <begin position="170"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30632" checksum="DE89E503B04344CB" modified="2021-06-02" version="1">MTSGLPCPLCEGPERRNALERTLRVLAVDDEAPALEDLVYLLRSDPRVAHVEAVTDATTALRTLHRAMDAGGSVDAVFLDIRMPGLDGLDLARVLSRFAQPPPIVFVTAHQEPAVEAFELKALDYLLKPVRAERLAESVHRIVHEGPTPKPAEPAPPPVEKKPDVGDEVIPVELGGITRFIRLADIRYVEAHGDYARLHTATGSGLVRAALNGLEERWRSAGFVRIHRSHLVALGHIEELRLEDGHLSVNIGGAVLPVSRRHARHLRQLLVRRNRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T267</accession>
    <name>A0A7W7T267_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="38023" checksum="9DC025B9314D3816" modified="2021-06-02" version="1">MTEPVVHEHVTDAVKTPDLVRLAPNVVLLRFETLKIHAALGAVRALLGAGVVRPGQTVVDSSSGIYAVALAMACHRYGLRCHIVASTTVDVTMRAQLEILGVTVDQMPPSDDLRLDQRRRVLRVRELVERHPDMHWMRQYHDPVHYLGYAEVAGLVAGALPGPLTVVGSVGTGSSTGGLTRSLRERGVDTRLVGVQPFGSVTFGSERFTDPDAIIAGIGSAIPFDNVRHALYDRVHWLDFQHAMAATVALLRDHAVFAGLSTGAAHLAAGWEAGREPGRTHVVIGADTGHRYTARVFARHREALDPADLAPREVDAVADLCPPWSTMDWQRRAYEPLVPAQERRKDPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F5</accession>
    <name>A0A7W7T2F5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator GlxA family with amidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="35623" checksum="895DB4C143E28667" modified="2021-06-02" version="1">MEREVLVVGYEDAVLTDLAGPLDVFEGARRVRGGYRVRTAAVGGGFTASGVRLRVEDLRDVVGPVDTVLVVGGQGCWAAARDPELLGHLTRMARGARRVASVCTGTFVLAAAGLLDGARATTHWAYCARLAAEYPAVEVVPDAIFVRDGRTATSAGVTAGIDLALALVESDHDAALARLIARWMVVFLRRPGGQSQFSVRSDVPAVRDGGLRAVLDEVAADPTRSWTVDGMARLAAMSPRHFARGLPGPGRPVARALRRTRPRRGGGHAAGVRRRRARRGRPPVRFRVGRDAAPRVPPGARHHAGRVPGPVPHHGCGLAMRGIEWTWHSCSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J2</accession>
    <name>A0A7W7T2J2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="29160" checksum="64D6D0B9E6AEA678" modified="2021-06-02" version="1">MGRVAVIGDVGGHADQLRWALEWLGAGAGRLPSDLTVIQVGDLVDRGPDSTGALDVVARLLDEQPDRWIQLVGNHEAQYLPGGTVFWPDPVEVCDVERLRAWWADGRLRVATAVRTGDGEELLVTHVGLTLAGWQWLGEPTSAVRAAESLDRRPELIWRMGEHARDEQAGPLWAESGAALHEPWMGYVGVVPFGQVHGHSTVVAFGEERWRCTGRVRQRASVDWQARHVRVRVGGRVFTGVDPGHGRTGATRWQPLVFDAATVVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K0</accession>
    <name>A0A7W7T2K0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="226"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="387"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="504" mass="54861" checksum="D9F94BFB0F5E5102" modified="2021-06-02" version="1">MPQYLSPGVYVEEVQSGARPIEGVGTAVAAFVGFAERGPFHRATLVANWNQYVQLFGGFVEDAYLPHAVYGYFANGGGAAYVVRVGGTPEGAQPQQPAREPVRLGDLRIAALPGVDGDVSVEVADADGENPPDDRFKLLVRQNGKVVETHDVTTRKNAKNYVATQLAERSKLVGVTEQPTGALARPDKQTVSLPAAATAPTTVDAQEYLGDPEARTGFGGLESVDEITIVAVPDLMGAFQRGLIDLEGVKTVQLALISHCEQMGDRVAVLDTPPGLNAQRVRTWRQDEAGYDSRYAALYYPWIKVFDPAGGRTTLVPPSGHVAGVWARSDVERGVHKAPANEVIRGAVDLETGLSKSEQDLLNPVGVNCVRAFPGRGIRIWGARTLSSDPAWRYLNVRRLFNFLEESILLGTQWVVFEPNDDRLWSSIRRNITAFLTEQWRQGALFGRTPAEAFYVKCDRDNNPQESIDLGQVVCEIGVAPVKPAEFVVFRLAQFSDSTSLVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L9</accession>
    <name>A0A7W7T2L9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="24368" checksum="509202B4A1C27DAB" modified="2021-06-02" version="1">MAQCRESRVTGALYIAGNPGGLFYLRDGVVTGVRSPGSPGADTLVARGNVGNADTRALTATVLHDGAFAMVTGDIERYVIGGSAELPFVPASDGVTVDQLLAETTDRLDVVASLPVLVSPHRDRVVPARSAGPAELGAERQEIVAHATGRRTARDIAFAIGASLYPVTAEISRMLDEKLLETAPAAAAFNFVHGGLASLRPRADTVTDRRAEEVGVPPLPTRRPGRTRSGPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T6</accession>
    <name>A0A7W7T2T6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6394" checksum="7688887E9272A7D7" modified="2021-06-02" version="1">MEALAAQATWRKSSRSSSNGSCVEVARSNSVVGLRDSKNPAGGHFTVSATAFNALLDGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T340</accession>
    <name>A0A7W7T340_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="5883" checksum="45D0F2BBF965E28D" modified="2021-06-02" version="1">MWRKSSRSGASNGGGDANCVEVHANLDAIRDSKNPTAALRFPVVAVRNFVAAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T387</accession>
    <name>A0A7W7T387_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="29" mass="3581" checksum="3EBA567C3A4262FB" modified="2021-06-02" version="1">MAKLAHAVLGALSIRLKDRKFRWYWYHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q2</accession>
    <name>A0A7W7T3Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13073" checksum="1F2703513F76C772" modified="2021-06-02" version="1">MGAHARGEVDLHGADPVADGEPGDVRADGGDDAGQRAAQADRAGEAEDRPGGSAGDEQVDAVDGRGDHADAQVAGSGRGQGHLREGGGGGVGPGYERERHDFSVRSGVHPTFGALLSVGKKALVSGVGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q9</accession>
    <name>A0A7W7T3Q9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030534963" evidence="3">
        <location>
            <begin position="34"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="466" mass="50959" checksum="A00AD68D07401B0C" modified="2021-06-02" version="1">MTMISALARRTGTVLAVIVATATLSSTASIASAATAFPTVDTNPASDVTAATAGTSPEGVTESTMTAAANDPISRTDVRTRARSWIDEQVPYSQTTWYTNQYGYYRQDCSGYVSMAWGMDKSYTTYTIQPFLETIERSDLRPGDVLWRHDPDVQHIALFMGWADAAHTRPIVWEEYDYQHFAEQRVWDKGWADSFHPRRYKNITSGNFGRADIVRINTDGTLTGWHNNDAFTGQWNAPANLGGVGPVDHTRLQLADLDGDNKSDLIRIEANGQLTAWWNNNAFAGQWNSPVNIGGVGSTDHTRLRFADLDGDNKSDLIRIEANGTLTAWRNLNAFAGQWSAPTNIGGVGSTDHTRLRFADLDADGRADLVRIESDGQLTAWWNNNALAGQWNSPVNAGGLGAVDHTRVELADLDADGKADIVRTNTDGTLTGWHNNNAFAGQWNAPANLGGVGPVDHTRLRFADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T426</accession>
    <name>A0A7W7T426_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase subunit of ABC transporter with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="327"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="539" mass="58274" checksum="EBB917633BEA4A0C" modified="2021-06-02" version="1">MSDAFVVLSDLSFSWPDDTPVFDGLSGTFAAGRTGLVAPNGAGKSTLLRLIAGDLRPTAGTATVDGTFGYLPQTLPLTADATVAEVLGIAEILSALDAVESGDASEEHFTTIGTEWDVEERTRAQLDRLGLGDLAMDRRTGTLSGGQIVSLGLAARLLERPDVLLLDEPTNNLDRDAKARLHDVLAHWSGCLVLVSHDRELLDAMDRIVELERGDLRSYGGNFTLYQETVEAEREVAARNVRNAEQDLKREKRELQQARERSARRAGNAARNLGNAGLPKLFAGNMKNNAQRSAGRADETHTSRVGDARARLDEAERALRDDKRIALELPDTTVPAGRTLFEGEGIRRGVLAGVDLTVRGPERIALTGPNGSGKSTLLRVLDGDLVPDEGTIRRADGRVAYLSQRLDLLDPDRTIAENFAGFAPSLPESRRLTLLARFLFRGARAHLPVGVLSGGERLRATLACVLFAEPAPHLLLLDEPTNNLDLVSVEQLEQALNAYRGAFVVVSHDERFLSGIGVRRRVGLVGGRLVAQQNSSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T436</accession>
    <name>A0A7W7T436_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20176" checksum="2CF863110B3B5596" modified="2021-06-02" version="1">MDNLQIFRRSFPDVDVEFRHPASYVAETADAVAALLYSYLFWPDLVECYGAVFIAINGNEDSDLEERIRRPVGDGHEDWPELSWAAFVESYNMYEVPHLFRMLRGPAEVYEPSHAALGAVLREAWEARLAAAYPDRCFGVDLLEGNGSVALRLVVRQKSPELVAPEGYDPRRRGVIGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T444</accession>
    <name>A0A7W7T444_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="19951" checksum="CF61E44700E8285E" modified="2021-06-02" version="1">MSGRFLRSAHGLVDVEYGHFLVESRLPLPAAPVPAQDVGLSVSRGAVVVAAEGTVTRYALVQLEAWSAAPDGDGVAEQVVCFPDAFVRALGLSAERPGTAELDLGAPGTYRVRLHRWGADDRRHEEFPHAAIHRVEHVVLRFWPTDEEAEEVPADPFFRYQAAIREWAWEFTRRADPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4D8</accession>
    <name>A0A7W7T4D8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031026722" evidence="1">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="28909" checksum="0A57A39B8E6AA729" modified="2021-06-02" version="1">MRRVLTLLATVVVAGVAFAAPASAIDPTKGYNGICTGADALTGVTVVIDFQELDGNGGTPAPTITRCSPNPVPGSQRTGIKALQDAGIAVAGTAQWGLGFVCRLEGRPAITETLPRNSQPTYKEACVVTPPADAYWGYWHAPGSGTTWTYSSYGAANRNVTPGGFEGWSFSLNKTASTNPVPGVTPTNPAVNSNAPSVGLSIDDVDRKITLGTSTSLTWTSTHSTTITAHAVSPATGGGSWSGALAVPGGTKTITPTAKGTYTYTIKAVGTGGTVYSTATLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T7</accession>
    <name>A0A7W7T4T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041443">
        <property type="entry name" value="Exop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18559">
        <property type="entry name" value="Exop_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031529634" evidence="2">
        <location>
            <begin position="26"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="79"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="4">
        <location>
            <begin position="435"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Exop_C" evidence="5">
        <location>
            <begin position="679"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="850" mass="89361" checksum="819FDED7EA26F817" modified="2021-06-02" version="1">MSRRHLGVVLTGVLAVALLSATAEASPKQPVVGEPRTENGCARIEKSLPVLADWPRVDNRVESNAADERRIKKIVGSLTLAEKVGQMTQAEISAITPDEARTYGVGSILNSGGSTPGMDKHASPRTWLAMADAFWAASTTSRAKIPLLWGNVAMHGNNNAYGATIFPHNIGLGAAHDPCLVREIGAATAAQIRATGQDWTFAPALTVPQDDRWGRTYEGYSEDPRITRAYGYEAVKGLQGSDRRRVGVLATAREFVGDGGTLGGRDQGSTPATTAELINVHGQGYYGALAAGAQTVMASFGSLGDQGKVHGSKAVLTDILKSKIGFDGLVVSQWNAVAQIPGCANYSCPQAINAGVDVVMVPTDWREFIANTVAQVENGQIPLARIDDAVTRILRVKLRAGVLDGVKPSARPDAGSAKALDARRLAREAVRESQVLLKNNGGVLPLKPRSKVLVVGKSADSLQNQTGGWTLTWQGTGNTNADFPNGTTVLGGLREALGAENVVFSETGDVDPAGFDAVIAVIGETPYSDGVGDLGRKTLEAARLYPRDLAVLDKVRGRGAPVVTVYVSGRPLYVNKELNRSDAFVASWLPGTEGGGIADLLVRGRHGFSGTLSYSWPREACQTTNTAGQDPLFKPGYGLKSWQRTAIGQLDESSPTGCGGDDGGTATEDLKLYDGGDVAPYRGYISSPDNWDGTEIGADGTAAHSTISITPDAGPSLRGTWSGTGPGQVYFANPAGGSDLRGYLNAKSAVVFDVVVHRAPTNRTALSAHCSWPCLAEVDVTKVFTGLTTGQKSTVKIPVSCLADAGLDLEKVNLPFLVFTDGPFEATFSNVRWVPKAAADPDAKTCAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T545</accession>
    <name>A0A7W7T545_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11634" checksum="F1863235A704E7F3" modified="2021-06-02" version="1">MERGILRAERDGVRGMVLLFRADDACHYSPRALPEAVTVGNLKRDDQRSSSSDYGTCLDIWAPGESIVSASHSDDSGSATMTGTWKLRVRDAAAKDTGMIDSRSLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T562</accession>
    <name>A0A7W7T562_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="28305" checksum="702AFA61511FFF20" modified="2021-06-02" version="1">MNALTEFAEAQPPLLALLLVVAGAAKLLPVVRGSGIAPTGVLALVPRRYRGAASTTLACAEVTLGIALLCIPALSVRLAVAASFAAAVLVVGFLWRRKPEAGCGCFGDLSGERVGARTLVRTCVVAVLAGIALGGRAPVSATLTDLTAVHVTTMVIEVGVIAALSPELALWWVRLRGRSVPCAYRRVPSAHALGKLRAHAEWHRYAELLTAAEPFDEWRDLCWQMFAFPGCRDGLDVDVVFAVHLDGRGPEVRVAVVTAADTGESVVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J2</accession>
    <name>A0A7W7T5J2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="48256" checksum="1AEDEAA261CB0490" modified="2021-06-02" version="1">MGVEQYGYAQELRRSLGFRDLLVYGLIFMVPIAPFGIFGSVFQGSGGMIALAYAIGMLAMLFTAGSYAQMAKAFPIAGSVYTYAGRGIGAPVGFLAGWLILLDYVLVPSLLYLIAGVAMNSLLPAVPIWLWVIAFVVLNTAVNYVGIELTALVTRVILVLQLVVLAIFLVIGVVALLQGRGRGFSFAPIFDGGTFSWSLVFGAVSIAVLSFLGFDGISTLAEENRDSARAIGRSMVAALLLTGVLFIVQTWVAALLVPDPAGLIENGDAAGTAFYDAARVAGGGWLATLTAVATAVSWGFANSLVAQAATARLLFAMARDRQLPAFLARVHPTRRVPVNATLLVAAVSLALGLYMQSREDGITLLSSLVNFGAMAAFLVLHVSVVVHYVVRSRSRNWWAHLIAPAIGFAILAYVVVNAKVAAQTTGFVWLGIGVLVLIGLLATGRKPVLSGVGATEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V7</accession>
    <name>A0A7W7T5V7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding CsgD family transcriptional regulator/uncharacterized protein YciI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18530" checksum="0A4A672393F4BD70" modified="2021-06-02" version="1">MRRSIHLAHREYWRPLAEQGVLVGTGPWADGSGVLLICQVPDEAAARDLVRGDPYVRSQSIAEVRIRQWHVLLGLPEGERVPGMVRPRDGQSADSRTREPLTPHEHRIALMMLEGMTNRQIAEHFSVSTRAVELHITRIYRKLDIGRRAQLAAAMPWGQRSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6F7</accession>
    <name>A0A7W7T6F7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031160883" evidence="3">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="207"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26653" checksum="4ADCF5BBEBAA7917" modified="2021-06-02" version="1">MRLGRKLAAVVAGTAVAPFVVVLSAGPASAHGYITSPPSRQAVCFAGRMSGCGDIIYEPASVEGLKGQKNCHGGDARWAPLNDDNKPWPAASVGDNVPFTWTITANHSTTTWQYWVGGSKIAEFDERGRQPGVTVRHNVSLGGRTGRIKVLAIWNIADTAMAFYNCVDLQVGPGGPGPTSTTKPTTTEPEPEPTTTTVPTTTTTTPVGNWAPGVAYSVGTRVTYGGASYRCVQAHTSLAGWEPPNTASLWQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6G8</accession>
    <name>A0A7W7T6G8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="204"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="439" mass="48895" checksum="D836134C17E8EAFA" modified="2021-06-02" version="1">MVLRLRVRRFFCDDQGCALETFVEQVDGLTVGHARRTLLSRTASERIGLMSAGRTGARLAAGPGLPSSRSTLLRLVHALPDPPVGVVEVLGVDDFALRRGRRYATVPIDAVTHRRVDVLPDRRAATLSAWLCAHPGVRMVCRDGSATYAEAVRQGAPDAVRIGDRWHLWDNLVAAVEKTVTAHSTWWYVGPERRTKTAEERTLQRHAAVHGLLDQGVGLLECARRLGVSLDTVKRYARIPSAEQLRRPPPYRRGMVDPYRGHLRRRLAQQPDVPVTHLLAGIRVLGYPGSANLLVRYLEQGRAEPDRVPPSPRRLVTWPTSKPESLPGHHRRHLDDLITGCPPMTTLAQRIREFAVILTHRRGQDLNAWIDAVLADDLPALHRFVHGLRKDDDAVVAGLSLPHSNGPTEGVVNKIKLLKRQTCGRAGFALLRKRILLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M9</accession>
    <name>A0A7W7T6M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-asparaginase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="32132" checksum="3697640315987796" modified="2021-06-02" version="1">MAHELVAEVWRGEFLESVHHGSVVVLAPDGTTRLSVGQPAAVAFPRSANKPFQALALVRAGYAERAELLALACASHSGEHFHLDGVRRILGRAGLDVDALRCTPELPIGEHALHAHLAAGRGPEPITMNCSGKHAAMLATCVVNGWSTADYLDLDHPLQLAIRATVEECASEPVGAVGVDGCGAPLFGITLAGLARGFGRLASAAPGTDEHTVAHAMTTYPEWVGGTGRDVTRLMHGVPGAVAKDGAEGVFAIGLPDGSAAACKIADGARRAQGVVLVAALRALGVDAPADLATVPVLGHGRTVGAVRPSAALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z7</accession>
    <name>A0A7W7T6Z7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,6-mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="493" mass="51972" checksum="2F01DBB10C9F1B4B" modified="2021-06-02" version="1">MRFAATRVEAAGEHDDPRGIPIRTILLGVAGVMLIALGGTGAGATLKRDPLLTDTSLSWIRYGHGHDLATAVLYIGLGLVVWAWVRLGRMVRNRHVGSAAVLTAVVAWTLPLLFAPPLFSKDIYSYLAQGQLALNGLDPYEVGPAVLQSPLSDNVSWVWQNTPAPYGPLFMMLAEGVVWATNASVIGGVVAMRLVLALGLVLVCWALPGLARHLGGRPAVALWLAGANPLMLVHLIGGAHNDVIMVGLMAAGVLLVLDRRHVFGIALVALAFSVKATAVIAVPFLVLVWARRMPGSRNAQLAKAVAAGGMTFVGVFAATTAIAGLDLGWIPALGTSSTIVNWLSLPSAVGDFAFTVTNLVVSVEPGVFMTIARGLGSLLLLYVAWRQWRAADEGGPGAIRHAALTMLALALLSPATLPWYFSWALVLGAGLAWTTPALNRATFFSVFLLLVTFPDGNTALYSWGYLVLAAGVSALACVTSTRPDPLRLSGRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7C6</accession>
    <name>A0A7W7T7C6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="40702" checksum="8FA0EA203132DDD8" modified="2021-06-02" version="1">MTTVDVVQRKVLRVLAGTQVLGSAGVTIGLTVSALAAASLSGSDTVGGVAQTSAVLGSALFALPAARLAARSGRRPALIAGYGIGALGAVCAAIGVITESWQVVVAALLLFGAAGAANLSTRYAAADLADPSRRARSMALVVWMATVGAVAGPNLAEPAGKVARALDLPVNAGPFLLSAVVFAAAGVFVLALLRPDPLTIARSRAAVVTPAHCAGGVADTRGSWQVWRSLSGQARLALSAIALCHTAMVGLMSMTPVHMNHAGSSLSVVGIVISLHVAGMYIASPVFGWLADRVGRVPVLAIGSALVVAAAAIAGMAESHDAPQLAIGLTVLGFGWSAGLVSGSALLTESVSPDDRPAAQGLSDLLMNVAGAAGGIAAGVVVATWSFAALGLVVGVTALPLLVVCLFAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H7</accession>
    <name>A0A7W7T7H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="31452" checksum="E2EE46BF7AE39F3F" modified="2021-06-02" version="1">MDVKSTLAVEWWVANGPKIAGGLLRIILIIVIAVVVRFLLRRLIDRLTKGSEKGKKPSLLKPLRERAPQALGALVSERREQRARTIGSVLKSVVTFIVYGVAFVQVLAELGMNVTPIITSAGILGVALGFGAQNLVKDFLSGMFMMLEDQYGVGDVVDLGPATGTVEAVGLRITTIRDGNGTVWYVRNGEILRVGNSSQGFAVAVVDLPLAYGANLAEASSVLTETVGTAVAEEALAEDVIDKPQVLGVEKVTPEGITMRVTVKVRPGRQWAVQRALRAKLMPALEENGISLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X7</accession>
    <name>A0A7W7T7X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8561" checksum="88D3FA758CCBB16B" modified="2021-06-02" version="1">MPEPEVAPPVAHEAATADIGAPCPEIVVAGEDRPGGAVPEASRRTSWVHPAAGGKRLAPAVPGMIAVHHRPSHGRDDAGHRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T858</accession>
    <name>A0A7W7T858_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="45801" checksum="1E0B8EA9778AFD2C" modified="2021-06-02" version="1">MGVLVAGCAGETGFDATSVPLTIKGGTVLDPQGLQVRAEAEVSYTLGFGYVARTDGDEVSCWFARVDPDSEVDTRLWCGPVQVPGTPTTTDWVPVPLKEVERTDAGVRLDVLPPQVPAFGAKSTPVGDLVRTDGRSASADQGVGEAGPDFLAVLPDDGRALDSATGRLRDDQLDVKLTGYARPSTVRTGQGELRAEHGVGLRVVRLEVDRLREADGAFDQKLWEGRGPQPPELSLQVPGRRHALSVDQLPKDGTVLVVYTVPSTPGAEELVLDSVGARPLVQRLSVTDGRTSDGPPALRREPAAQVDGVSAPVRVGSSSGTLAVKRVRVGWQRPVDLGGRYRLVTADEGKALVELRLEGQGLVSVLGAPETVKLLGTSAGARVVGAQYGGDTFPYAVIVEVPADAKSVELTVAAGRPVLPNLGATEVTAARMTVPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E4</accession>
    <name>A0A7W7T8E4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfate adenylate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="6">
        <location>
            <begin position="37"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="34715" checksum="CDD3E01A5A3B8922" modified="2021-06-02" version="1">MSGTATTGTSSTLDTLGRLESEAIHIFREVAGEFDRPVILFSGGKDSTLLLHLAVKAFWPAPVPFPLLHVDTGHNFDEVIEFRDRVVAEHGLRLEVAKVQDYIDDGRLSERPDGTRNPLQTVPLLDAITSHKFDAVFGGGRRDEERARAKERIFSLRNAFGQWEPRRQRPELWNLYNGRHRPGEHVRVFPLSNWTELDVWHYIAREGIELPSIYYAHTRDVYLRDGMWLAEGPWGGPRDGEELITKTIRYRTVGDGSCTGAVESDATDIEAVIAEVAASRLTERGATRADDRLSEAAMEDRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z9</accession>
    <name>A0A7W7T8Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="622"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="862" mass="90767" checksum="1E327AA826D50EA7" modified="2021-06-02" version="1">MPPLRAAATDVRSPLSGVAIAAALHREAFDAASAGRPVDAVRLLRRALTVLPAEPGDADATSVRVRILITLSYGEAETGSIADGLAHLDAATLLVEALPEGDLRIGLAPVIKCQQALLLHRAGRTAEALTLFDAAITGLETGHELGAVTTDRLAGNLINRGLTRIAFGVLDGAEQDMHRTIDLAEAADLPLMKAKALHNLGDIAQLTGDVPTALRHYDDTVREFRALAPDLVYRVRIDQARTLLAAGLGEEAAQHLDEALAVLRERRVGQDLAEAELSRAAAALLHEDPGLARDLAGRARRRFLRRGSTSWAELAALTRMRAELDVPASRIATPRRAVDLAGRLAAVGLADESAVATMLAARMSVRRGALDSARSLLADLPHPGPTTPIDHRMLLRLCQAEVAVAAGRDAEALAQARAGLEELGVVRDRMGGLDLLCGTAVHGRELGELAVGLVLDRGGDPAAAFDWLERTRAQVYRYEPLPAMEDTSLARRVNELRSLSRSIQQARLEGRPIEETAARFSRLQREITRLGWHTSAWGRPRPVARLADVVGALGSRALVSFVSHGDVLRAVVVVDGRASLVRLGAWADVSELARQLHADLDALAPDLMPAPLVAAVTASATRRARLLDDALLGPPASLVGTRELVVVPTGDLYAVPWGALPSLHGRPVVVAPSATAWLTASESAARSSASRVALVSGPGLSEARGEVHGLLSTYPDAVEPSSVADVLAALDGARLAHIAAHGEHVADNALFSRLELSDGFLFAHETVRLKRVPEQVVLAACSLALSRIRPGDEALGFAGALLAGGSHTVVAAVNKVGDRAAARTMDVFHELLSSGAPAAAALAEATASDPLRRPFVCFGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T952</accession>
    <name>A0A7W7T952_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9109" checksum="DBA1DF5C4DD9A73B" modified="2021-06-02" version="1">MTALTLATLAQQTTPGTTGVRQWILDNLVPLLLLTVALLLLWLGGGKGDNAGVMRRLGGVIIALAIIGLAVTTNAGANIGSWIAGLFTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T956</accession>
    <name>A0A7W7T956_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent MidA family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="31917" checksum="8F888BF3DED21948" modified="2021-06-02" version="1">MRDSEAAWRAALYGPSGFFTLGERPVDHFRTAPLVGPELAEALLVLLERVDAALGRPARLDFVDVGAGGGELSGAIRRLAPSRLADRLVVTAVDVGPPRAVPGVEWTADLPRSVTGLLVGHEWLDAIPCPLVSWPCADPWVRRWWPLRPGWSAEVGRPRDEAWADAVARVRGAALAVDYGHLLADRAAGRYASGTFAAYRAGRQIEPVFDGSCDLTAHVALDACAEAAGEPYMLVSQRDALEALGVGASAPAGAGMAWLDSAARAGRVAELRAIPGLGAFGWLLHAREIPMPLPPLPAWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T968</accession>
    <name>A0A7W7T968_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase (Penicillin-binding protein 4)</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00666">
        <property type="entry name" value="PBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="543" mass="54933" checksum="2CABB70FF96B4A19" modified="2021-06-02" version="1">MSGSDQARPDQNRADQARADRNQPGPAGPDRSRFEVARAQSPADAKDTERITVPTGAQAESPAEAPAERAMPRRIEPRAEDHAVAVTPKKKGRKRKVLGVVAAVVVLGAGTAFAGVGLDWFAGPPTPTTAAPAPPADIAFALRGVGTDAPAPSAAGVAAVVSGPAASAALAPLSGRVVDPASGTTLWEQGQGSAYTPASTIKILTSAAALLSLDHTAQFSTKVVRGAEPGTVVLVGGGDPTLTALPAGQRSMYPGAPTIDDLVAQVRKTGPVTKVLYDTSRYTGDGFAPGWDPADVAAGYVTPISPLIMDGGRTDPKAVDPPRHAAPAETVAQTFAQRLGVTAVATGPAPANAEVLGEVKSQPVDRLVENLMQVSDNVLAETMAREVAIATGAEPSFAGAAQAVVKVLTDNGFDLTGGTVVDGSGLSPNDKIPARLLADVLVAAASPNPTAPKTAKLRPLLTALPVAGGSGTLAGRYGESIGKGWLRAKTGTLTGVNSLAGVVVDKDGRLLVFAFMSLSTLPNADVRQALDVLAASLRSCGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T982</accession>
    <name>A0A7W7T982_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26320" checksum="D27A071513E67D0A" modified="2021-06-02" version="1">MNDPLGRAWIAADDKAAVADALARHGLVLVDGLSDSADVLRLAQSVATVVPHRDSASDGVTTLVDLGSDASGFAGFSSCALAPHTDRSGVANPPALLMLGCSRRATSGGQCVLFDGLAVYETLAETEPDALAALRAPRSVLFGGASGHLGAIFTEYDDGRVTVRLRQDDLVQFSPDVERSLPTLRAAIEQHVRELDLSAGQGYVLDNHRWLHGRRAFIGHRVVHRINGNPLPHLGIRTGIPTRARSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T997</accession>
    <name>A0A7W7T997_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="356"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="562" mass="59020" checksum="0822FF37B680C335" modified="2021-06-02" version="1">MTARTPSRVRRVVLPLVALVGIVAAAGVTVVALRLTDGEDCTGTLSLKVAVAPGAEGVVRGAAEDYQADQPVVEHRCVQVQVEARSAPDVANELPTAQINPPALWIPDSTMWAEQTKRQAGEHGADAPTLELGPSLATSPLVVAGSAKAVGALGDSVSWAGLIDPKARATLTDPTTSTEGLAALAIVRGLLGNPDGTPKPELIGALMRVGRNALPSVRDAFTKITQGSGDDAPVFATTEQSVLDANRVAGSRKVVAAYPKEGTLAFDYPVVRVGRAGEPAGTAQAAEDFERHLRTGRTLQRFAEAGFRTTDGKAPQGWKTDREGVRGEDVSLLTRPDADQVAELLRTWGAVSLDTRMLTLLDVSGSMAEPMEGSRETRIGAARDAALTALAMLPDTSEVGLWAFGRNKRPPDDWIELISTGPLGETVAGTTRRARLQTSAGGLATLVGGGTALNDTVLAAYREARRTFDPMKINSVALITDGSDDDISSIDLPTLLSTLREEADPARPVPMFLVGLGADADLDALRQIAEATGGKAYQALKGEDIRTVLLDAISQRRCRPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B9</accession>
    <name>A0A7W7T9B9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030997311" evidence="2">
        <location>
            <begin position="28"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="375" mass="38057" checksum="970E8E212BC3332D" modified="2021-06-02" version="1">MAILRRSVLTIAAAAATWAFSAGTAGAVPIDNPVADALKPATTTDSAIAQPVLDVIGEIVPTATDGNQSAADDAPATAADPLGLDDLTTTANEIADIGQTIADTVTDTVSEATDTVGDIVPEVAEATDAVDTETPADAVVDVVADVTADVTADVDADLDVVADVVADVDADVDADVDADVDAVVDVAADVVADVDLDVLVDLEDALEDLVDADVDVVVDAVVDADVLADIDALIDLDLDLDVVLDILDDDGIHIYIGGIEIDIDDLLDILIDLDIDLDLDLDGLIDIDLGDGGLLDLDGDVLIDLDIDLGGGDGGLLGLINIGGDDSDEPAADQPSDEPTDKPSTDEPATDQPAQDEPVQDQPADDGASFSAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I5</accession>
    <name>A0A7W7T9I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="28636" checksum="AAB3992D55092233" modified="2021-06-02" version="1">MRVMITGAAGYVGRAVVAELDRAGHAPVPFAGDVRDSAAVEAAVRGVDAVVHLAARSRVRESFDRAAEYFDVNVGGTLNVVRARPAVLLLASTAGVYAPAPSLSEDSPLKPTNPYAASKAVAEEVVRWTPGASAVLRLFNVAGGGDADPTRVITKACLVAAGREPSMRVFGNGSAVRDFVHVRDVARAFVAVLENTSSGHEVYNVGATPASVAEVIATTERVASRPVAVEWAPANPGEVRELRADTAKLRDLGWSPEESGLSDLIADQWRSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9M1</accession>
    <name>A0A7W7T9M1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="11">NN:DBI PRT</shortName>
            <ecNumber evidence="5 11">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobT</name>
        <name evidence="12" type="ORF">F4559_005114</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="5 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="35870" checksum="3F40806FD8415ACE" modified="2021-06-02" version="1">MTIEFPPVEAPSEAVRQRAERRHATLTKPTGSLGRLEELGAWVAACQGECPPRPFTRPRVVVFAGDHGVARHGVSAYPSEVTGQMVANFLNGGAAVNVLANVAGATVRVVDTSVDGDTGVDEHKVRRASGSIDREDALTLEEAEQAVELGRRLADEEVDGGADLLIAGDMGIGNTTPAAVLIGVLTGSEPVAVVGRGTGIDDQGWMRKTAAIRDALRRARPVVSDPLRLLATSSGADIAAMAGFLAQAAVRRTPVVLDGVVSGAAAIVAEELAPGARKWWVAGHRSAEPSHALALNHLDLEPLIDFDLRLGEGSGAVAALPLVVMATRVLAEMATFESAGVSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P7</accession>
    <name>A0A7W7T9P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhamnopyranosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,3/1,4-galactofuranosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.287</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.287" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="33451" checksum="13D2838547A57CB6" modified="2021-06-02" version="1">MSALPKGSVVGVVVTRHRRELLADSLKVLAAQTRPLDHLVVVDNGPDQPVEDLVEQCPIPTTYLVSHRNLGGAGGFALGMLHALALGAEWLWLADDDGRPADETVLAVLLEEADKRKLAAISPVVANIERPDKLAFPLRRGLTWKRDAADLGDDFLPGIASLFNGALFRASTLDVVGVPDYRLFFRGDEVEIHRRLVRSGVPFGTSLRVAYLHPDGSDEFKPMLGGRFHAQDPENPVKRYYTYRNRGYLLSQPGMRKLGLLEVFRFGLYFVGVRRDPKAFLEWLRLVRLGRRERFFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9S3</accession>
    <name>A0A7W7T9S3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="12816" checksum="F2DCF84889CFAF82" modified="2021-06-02" version="1">MAENIGTGRVRVEWNGVAIDTAAHQGAARGLGLGAEHVRGVSVDRAPLDTAALRNSATASVDAESLTAAVSYDTPYAARQHEELDYHHRTGGPKYLESALASERDVVARLVQAQIRKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W5</accession>
    <name>A0A7W7T9W5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018575">
        <property type="entry name" value="Restrct_endonuc_II_Eco29kI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09517">
        <property type="entry name" value="RE_Eco29kI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="55"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="32793" checksum="62088EAC7A86E862" modified="2021-06-02" version="1">MTGALFSPMGKPDPDVPAAEFKLNITKALGDQLQERLASLRRAPLTPPTVAAIEPLAGVYELWHGDKRVYVGKATASKGLNQRLSEHLRKLSGRRYIDLAEFTFMCLYVEEDLDAAAPEKLLIKRYRNTSGCPWNNNGFGNKDPGRNRDSSRVKENHFDARYPIDTDREVTDLGSSSWNVLDTLLAAKEKLPFLLRFPTDKTDKAAAKRLQAANITTLPNGPITFRRLMSHVIDALPEGWQATALPGYAIIYQEVKDYDSALTIWRKRSGMVVEEEIKTVYAPAAAIKDSGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA54</accession>
    <name>A0A7W7TA54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="33599" checksum="9B0962E87F6BC125" modified="2021-06-02" version="1">MEGELMSLRGKVAAVTGATRGAGRAIAVELGAAGATVFVGGRTTREHRSPIGRSETIEETAELVTAAGGQGVAVRCDFTRPSDADEFRARIEEHGQGLDVLVDDVWGGELDSEFGPFWTLDLEKQLRLWDNSVRAHLVTLHRLLPLLTAKPGGLLVEVTDGDDDEFYAESLAYDSVKVAIRRFGKVLARELEPHGGTSVAITPGFLRSEQMLEHFGVTEENWRDAIAQEPHYAMSETPHYVGRAVAALAADPDRHRFTGRALASWTLMREYGFTDLDGSKPDWGRWFEEVFKAGVDPKTADASKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAD7</accession>
    <name>A0A7W7TAD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017349">
        <property type="entry name" value="UCP017349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14476" checksum="AEBF4274D0EF9652" modified="2021-06-02" version="1">MTNLLGPDPTLLPDRPEAQAAADAGTDPAKIVHAHPDFSEAWALLAERALQSGDPVAAYAYARTGYHRGLDQLRRAGWRGHGPVPWSHRPNRGFLRALAALSRAADGIGETEEYERCRKFLADSDPAAPAALGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAE6</accession>
    <name>A0A7W7TAE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding Zn ribbon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18533" checksum="7A5C664B58F38731" modified="2021-06-02" version="1">MTRPGLDLVATVRSRLGGVPCDGVTTPDTLAAWLSAQGHTVAERPDEAHVREFRALREAAYRLLGAAVDGTTPARVDVDLVNRCARQPAPAVVLSPDLAAVRERPTVAQVLGVLARDVVDLLTGPDRDRLHQCEAEVCGSYFVDTSRAGRRRWCSSATCGNRVRVAAHRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT84</accession>
    <name>A0A7W7WT84_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="34600" checksum="1A03D4732A6D5383" modified="2021-06-02" version="1">MPSGVGTIDTRPRPGRRVDHRVGWTGCRAEAAAAPHPHRAAPTTPTRHHTHDARPTRLRTGNAGPTRHSPTRHRTYPAPDPDAPDPARLTSATPHGILTQRAEPGGTAPGARAGSPSACSGPVEVAGGGAAGRCGPGGLPVVDRLDARMGRGFRSTWPSRRSTWSGRHGRGVSTGGGGRRCRGPGDDLVRDRSGGWGVVGSWAREGFVGPVPEIQRGGACAVCVSGGGARRCVFVVSPGCVITEFAWNRRSGVRVAAGATSGPWRAAPPRVVPGGLDHLVPQRIPSRRATTPRHGRRAWSPALRPFTSGHGRLRGDHPSNELTRFSRAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN5</accession>
    <name>A0A7W7WTN5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase (DIM6/NTAB) family NADH-FMN oxidoreductase RutF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16474" checksum="0DBD5990E43F539C" modified="2021-06-02" version="1">MSDLRTALRDFPQGVGIVTASGPEGPVGVTVSSFTSASMHPPLIVVWIGEGASAWPVLRTAPLFAVHLLHAGQTDLSDLFARTGSDRFGPDTKWESDVDGVPHLLEAPLRLRCRTARRISVGDHVALVGEPLEIQHATGNSPLVRFQGRYTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR5</accession>
    <name>A0A7W7WTR5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061810">
        <property type="term" value="F:NAD glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1864"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2072"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1881"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2086"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2230" mass="224942" checksum="2F1C870E115446CB" modified="2021-06-02" version="1">MGIEIPSEVTWLFPIVVGQSWPEGDETALRRMADAYRTAAQGVKSVLDEANGAASTVMSSQTGEAVKAFEGYWKKFADGDDSYLPKLQKICEQLAESCDNTALEVEYTKLSIIASLIALAIEIAALVAAAFGTFGASTAGIPIAQQATRLIVQFTFRQLIIAILKEVAISVGIDAAIQGIQMLSGERKNWDWGKTGEAAVSGAVSGLVGGVSGGLKFQGGGLAGQMAVGATRGAVEGAVSTVGTAAVMGQDISAKDVLLGATSGAVSGGIGGAKDGITVEAPHVTPGGPGGGPPDLTPPAGGPPTGGPPGAAPTGGPTGSGPTGTGPTGTGPTGAGPTGSAPTGAGPGGGPSGPTVNRDGLNRPRGTDTTTASSVAAPPAPGPSVSMPPPVGGDHSSGGPTSSPGGFTGAPTSNGPLPTSTTPSSGGSSIGNRLGAPTTGGPTPGGPTATPGHGGTSPGTPAAGRTPTATPGFGPGSSGSHPTPGASGGHGTTSGTGATHSTPGSTGATPGGHPTPGGAGTTPGHGSTPGTGSLPGNGSTPGTSAPGGPTSGTGPNPGSGATPTAGSTPGAHSTPGSGLPGSGVPGAGPAGSGLPGSGPVGSGAPGSGPIGSGVPGAGPAGSGLPGSGPVGSGLPGAGSAGSGLPGSGPVGSGVPGSGPVGSGLPGSGPVGSGVPGSGPVGSGLPGTGPVGSGLPGTGPVGSGVPGSGPVGSGVPGVGPTGSGLPGPGPVGPGAGPHGGGPAPHLSGGAPGAGSHSGPASGTGPMGGGGGFAPPPGGGAPGGGGGGLGGGRPSAPTASGYFSDDHSSGVRGTDAVSASSVTGAPVEAYANPSYQPTPDQRSAIPQQPTGFGPQQGFGPQQGYTPPPGSSAPAHQAPPGGQPPRPDAAPRPTRPDAPFARGPEALARPDAPRPSDGRPTDTRPGSPAGRGPDAPAPRGSEPRGSEPRWEAPGGRGTESPASRGAEPRWEPPAARGTESPTPRVAEPARPDAPASRGTDPTRPDGPATRGTDAPTPTDGPASRGTEPGAESPVSRGTDPTRPDGPVARGTDTPAPADGPASRGTEPPTTGDARPDATPTDATPVDSTPVDSTPADTSTDPAPGTTDPADRVPADSGPTDPGTETPDKIGAPGDEHTPAASHEWPTDPGTTDPGTTDTAPADSTPSDADPFPHKGPWNNPAGVVEGFSHDGPYHSVHDSTGPTDREVGTYDQRAAAIIEPTYQPYGPYGSYEPFIQAHSRPDGSIAWPPNQGAGGPRVVVELPAGTVLDRFGSPMGDFLSPLRPDGQAYGFGERAIMPDSMGKGYHVYVLDRPLMVELAPVAPAFDQTGGARQLQPVAHPDLVDPATGNMSVQHLIDLGHLHEVDVPPADGRVLPPDFGTFDENGNVRTPDTVTVDDARDGAFDDYTPTTNDASNLTPNPDLGPVAHRGPIPLGEVSQRVDQAIRNSTPTDAGVALHTEQRLRDLSARIPQSGDHVVLDVHTDGDGVRIGDTHYTRPELVELINNHPDLAGRPIMFVGCEAGVGGENSLASYVARETGQQVVAPDNLAWSDPDGNVYSSSRDGAGPTLPPDGGWHAFDPDGTITPTGENGMPPGHEPTGDLGDESAHRGREHLEPQVQTQWEEPTTTHRESVTLPEGQSYFEGRDLPRDTSVEVRDPDGRVRSVVHVDADGNVSVDARATNTRENPEVARPYPNADYRVEIGNRNDAFVANADGTMRTWTDEIKVGGRTVEVERRVIVDEVPEPANGRQTIDRDHPMAPRPGEAFVARTDLPADTRMEVYDTEGNYRGTVQTGADGRPRWVAAPDFWGTADEPHRNPETTHVIEGANYNIDRGPLHQEFRTDEHGNPQDAAPNVAPRFENTRTVDGLRQNEPFSRPGQVHDRSTEYTVSDEHGQPRGRVITDENGLVVYEETFSGQRSRANAEITAAPPTAVVTSDGFYGLDRGDATSPVPTWPTPVGEVHLGIEVVRDENGRNVPTVRVLDGDTSGWTPEQRAAVERPYDNSNPFSGREDLPPGTRFVLEDRQGNGYSTIQTGDDGVPSHVHTFRPFSADMNTPLPNATVSADNGMWTGRTDGLGETTATTGRPDFNSGGHIRRDETAQRNVGDHGEVSVDPETGKKTKLSDGGHHGGNEMGFPGEEINQSSQQRDENQGNRRPAFATDETWYAMERDRARFVAEGLGTVESVDTFALRDPGQRHPHTYQTRWRVTLPDGTTRNYFRSYPNEHNAALWPSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR7</accession>
    <name>A0A7W7WTR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31256" checksum="F5D12C91A8A88F8C" modified="2021-06-02" version="1">MDNRSIVDNWYGAIGRGDLDEIMAGLSPSVVLELPEDQWNAVIPYLGTHVGLNEVAEAFRIRAETTEVLDYGLRGLFVDGDTALAVVYTKGRHTRTKVLFEIEDMHKLVLDAQGKITHWKVYFDPNTEVNAFNADREQRLYAAAARGDGAEVRDLLRFGGDPNRHDVGSGLTPLMAAVALGADTVVRTLLTGGADVLVTERSGQTALHKAVENGSADIVRALVRAGSIVDAPVATTGQTPLHVAVRHGNAEAARVLLESGARADLVDHLGRTPLDLARDLLPVEVVAALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ7</accession>
    <name>A0A7W7WTZ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18561" checksum="26470A963D80EE95" modified="2021-06-02" version="1">MTVGDGEPRTQWAFGERLTASLRQRGWSQNRFAKRSGLSPQTVSNLVRGYMTHLPGEPWKPSEDVVRRVASGLEERPSVWLRLAGYKVEASEEEEPPEARHLAGKLVKLAPADFSAIEAIVDSLLRARGYDVGPGPVVHSGSEVAAAGDRAGDEIAAAGEGATLADTISTRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU74</accession>
    <name>A0A7W7WU74_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Virginiamycin A acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23853" checksum="AB051BC51E1BA08D" modified="2021-06-02" version="1">MIPDPTLLHPLAEHPRVVLLKPLVTAPTIEVGEYTYYDDPEYATEFETRNVLYGYGTEKLVIGRFCAIATGTRFVMAGANHLTSGVSTFPFTIFGGTWAERTLDLITGMETRGDTVVGNDVWFGNGAVIMPGVRIGDGAIVATGALVTSDVPPYTVVGGNPARPIKRRYPDEDVERLLRARWWSWPIELVTEHVRTIMAGTPVEIERIAVEHGLVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA3</accession>
    <name>A0A7W7WUA3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="6" type="ORF">F4559_001335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31042" checksum="FD3AD785FA99C986" modified="2021-06-02" version="1">MSVRAALKPGVLSPRRPVPDEIGRPEYVDRPEPRRNTDPWVQPPEVIEAMRVAGRLAAQALQAAGAAVRPGVTTDEIDAVAHEFLCDHGAYPSTLGYRGFPKSCCTSLNEVICHGIPDSTVIEDGDIVNIDVTAFIGGVHGDTNATFLAGDVTEENRLLVERTHEATLRAIKAVKPGRQLNVVGRVIEAYANRFGYGVVRDFTGHGIGRTFHSGLVVLHYDAPHVPTIIEPGMTFTIEPMITLGGIEHDIWPDKWTVTTKDKSWTAQFEHTIVVTDDGAEILTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC3</accession>
    <name>A0A7W7WUC3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030657625" evidence="1">
        <location>
            <begin position="20"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="77"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="518" mass="55125" checksum="C22DEC4A25262F6A" modified="2021-06-02" version="1">MSESVRSMLLSLSLVVASAAACTGSTTPSAEGTSDGSAIVLADRVEPTSLNPLLGYGVEGVSKIYDGLVEHRADASLRPQLASEVPVPAADGLSWTVKLRDNVTFGDGTPFAADDVVATYRALLDPRTGSTERATYAGLTGVEQLDVHTVRFTLDHSWAAFPHLLTLGILPSESLTGAPLADIKPVGTGPYRVVEWRKGDRLVLEANPTYFGGVPEVRKLTVVFVPDDNTRAQRMRDNEFDGTELPPRLAAGFSGSGDLRVLTHESADLRSVTLPSGPVTGDPAMRLALNYAVDRKKLVDGLLGGQGTPASAPLPAALPEFATTEVDFAFDKARAEQTLDSAGWTRGGDGLRARAGVVARFTLMYPIGDVVRADLATAFAADARAVGVDVQLAGLSWDSITPRLGTDALLHGDGSPFDPDLAAYRVLHTGNPWGYSNTSVDAALESGRALLDAGQRATAYKQSQRAYATAPGLVVLASVKHTYVVRENWNGYEQVVDPHRHGALSWGPWWNLEKWTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUI2</accession>
    <name>A0A7W7WUI2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="460" mass="51196" checksum="787C531091F98C49" modified="2021-06-02" version="1">MFQQTAVGVRYDPPGGLDDFTPRQREQWHVAVSGWFDEIIAFHEEHTLRPGDPCQYYNQAETTPPTPGLVQAIPWNALSNTLVRRNGHAKALELAERLYPLTDRIDGAGAYFTGEVWEKTYYRPHDEYCEFRVEHDAQGKIARVVFTSEPPEYWQALHGDTLPGSAPGSAARYDFDPNRDMLLDLYRRHVHPSVRLADLQAAEDLVDESSGEVIVARGAYNPWNRWNTTHGIMHLCQPANTLTAEIVLGADATVPRARGGRPIEHADALLCAAGYGGPMRNSDPTIGGSVNVLARQGFWITLRNPVGLYMNHLDLAGITHRDGRPVTADYFRVERGDARQHLIERAVFEIPPDAQRRTGEPETVGDLLIAGDPIRYGAQLAERITVALFGVANPGEFRTTPLPATHRGCQDRVNGMFLRVVPVTDECPDGTRPAFDYPGSADVAHLRPAPEPHKPHRHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW8</accession>
    <name>A0A7W7WUW8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiL</name>
        <name evidence="5" type="ORF">F4559_001247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="31317" checksum="63CBE5417220E7CC" modified="2021-06-02" version="1">MGEFGLIRRVTSGRTQPPSTLLGPGDDAAVVAAPDGRVVACTDVLVEGVHFRLDWSSPEQVGRKAAAVNLADVAAMGAMPTALLIGLACPADTPTSVIEGITAGLWQEAAAAGAGVVGGDLVSSATLVISVTALGDLGGFEPVTRSGAQVGDVVAVCGRLGWAAAGLAVLGRGFRSPVAVVNAQRNPEPPYEAGIRAAEAGATAMIDVSDGLLADLGHIAEESGIGIDVRTELLEVHTRLVDVASALGADARHWVLTGGEDHALAATFPDPRAVPEGWRTIGTVRHGSGVTVDGRAYEKPPGWEHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX9</accession>
    <name>A0A7W7WUX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="21015" checksum="D243AEE42791E8B3" modified="2021-06-02" version="1">MRWTVRVGRPDDAPEIARINVDAWQHSYRGIVDDPVLDRMLPESRLPALTRVLRLPEPSRVFVAVDEDGTIGAYCAVDAVREGDDAHPDLHTGELVAIYADPRVHGTGAGHVVHEAGVKHLVDQGFRYAVLWVFQDNARSRAFYEEHGWRHDGLVHRYELAGSHLPEVRYGRFLPVPRRRAQSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE0</accession>
    <name>A0A7W7WVE0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="28866" checksum="ABA85983172E73EE" modified="2021-06-02" version="1">MATALRLRDGFLRFVPSLVLLTALVVFALLAFLAPGAVTGAVYRIDTPGFSVSHLDLTCAPDDAGMLHCPIDVAGRRLTVRTDPAPLGGVCRAWFDGRQLSCDKAGEYNLGSPWLRLDGPVLPEAETAGLRSDFPWWHDVVDRYWPLAVLVVTVALALIAAVLAFLASGRPHLPHPKRGWYTAVVGAGVVLVLVLAGGATMGTRLWWILVVPLAPGLVPLLVMPVWQWYASGGSDGRVGTRTKHTAVAFLSALVSGFVLVGLVTFLAGMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV7</accession>
    <name>A0A7W7WVV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="29707" checksum="3AB1834D5EF35669" modified="2021-06-02" version="1">MSRFLDTGEVPSPDCAAVATVSCTTLYRDDAAFAAYAVSRQTSTTTDDGARRESLCRGELDLAGRGDLGRVIDLMCGVGGHLAAVKGSDLGWTSYTGIDVNPVAVEAARQAHGGDDRVDFVEADIATWRPEPGTADTVLLMYEALNALGPTRTVALLEVIAGVLAPGGVALVDVAPPADRGAAREAVLLPDPQTAVLSGVDDAGSDATQRLSAHTVHFVGADGCRLHFSHLWWEPTADLLRALFHRAGLDIRSEHRVHGDVVSDKPSTAQSIQFVLTRAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW41</accession>
    <name>A0A7W7WW41_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid-associated protein YgaU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018911">
        <property type="entry name" value="Gmad2_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10648">
        <property type="entry name" value="Gmad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="111"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17699" checksum="7538A32800FD2ADA" modified="2021-06-02" version="1">MSIDVQMPRPYSLVDNHIRIGGVAGGAFEAQYSYRVHEGHDEVTGGFMAGDGVGGHGQFQLVVDVSSAAFKLERIFVEVFHTSPKDGAELDRVVVPIVLGPIILPGYRVYLEHVVVAGETLWGLSTRYYGSGNLYHRIVAANPGTITDPNLIRPGDVLRIPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW71</accession>
    <name>A0A7W7WW71_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase (NAD+)/betaine-aldehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
            <ecNumber evidence="4">1.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EC" id="1.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008802">
        <property type="term" value="F:betaine-aldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="12"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="49424" checksum="713D670E3F2F6CEF" modified="2021-06-02" version="1">MRSTALYIDGRWVDGADSFTTTDPATGAALAHVASASAADVDAAVASARNALPSWTATPPSVKAKLLWKLADLIEADGDELAALETSDQGQPLGIARNVSVTGAAEHFRYFAGWATKIDGTVNTVSFPNTLQYDRRVPVGVCALIAPWNFPLMIMAWKLAPALACGNTTVLKPAEQTSLTTVRLVELAVEAGFPPGVINLVTGGPETGKALVAHPGVDKVSFTGSTEVGQAIVSASASDLKRVTLELGGKTPTVVARSADIDAAVAGTVAGGLLNSGQVCAAYARLYVDSKRRDEFTSKLAAAVAGLRIGAGADPSTELGPLVTAEHRTRVDGFVQRAIAAGATLATGGSVVDGPGNFYHPTVFADVKDDMQIAREEVFGPVLAVLDYDDEDELLARVNDSPYGLAAAVWSDDLRSAHRLADGIRAGAVFVNMPCIPDAAAPWGGFRSSGWGREMGPYAIDAYTEVKGVWIHHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA6</accession>
    <name>A0A7W7WWA6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="35" mass="3478" checksum="99704F4FFA336E3D" modified="2021-06-02" version="1">MVDLVGDESGHAAFEDGDALVAGDVGVLDVQDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWD3</accession>
    <name>A0A7W7WWD3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acylphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031249917" evidence="1">
        <location>
            <begin position="31"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="39702" checksum="C2A5E4F446BB79EA" modified="2021-06-02" version="1">MKNRLAARLLIGAAAIATAVVTAIAPGASAQPGVAPAALPATAERAAPLTYAQGVGRNADGRLEVFARGTDGALWHIWQTAPNNGWSGWASLGGYFTGTPSVINNADGRLEVFVRGGDDAVWHIWQTAPNNGWSGWASLGGTITSDPVAGRNQDGRIEVFARGGNGSLWHIWQTAPNNGWGGWAGLGGYFTGSPSVANNADGRLEVFVRGGDDGLWHIWQTAPNNGWSGWASLGGTITADPAAGRNQDGRLEVFVRGGDGSLWHIWQTAPNNGWGGWAGLGGFIGTPPVVGNNQDGRLEVFVRGGNDALWHIWQTVPNGGWSGWASLGGVITSVPAVDNNADGRLEVFARGGNNALWHIWQTAPNNGWSGWASLGGVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWD5</accession>
    <name>A0A7W7WWD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="34555" checksum="D04AD29B1C743B89" modified="2021-06-02" version="1">MRTTNRRLEILSVLQAQPGISAARLAARLGVTERTARRDVAGLRELGYRIDGEAGRAGGYRLASGQAMPPLLLDADEVAAVALGLRTAVTVEGVETAAVTALAKLTQVVPARWRTRLAALADIEAPPDEPTRRARGEVLVPAALAVRAHEAVRLRHRRTDTTPSKPVDVQPHRLVALRRRWYLIACPRGEDRWTTYALDRVDHVQPLATRHPTPEPPDDPVGFVADSLAHGPWRYRVRVRVHTSADLVRESVDPTVAAVVDLGDECELRFGTDDLDWAARWLTYLNLDADVLEPAALTTRLHALGRWLHQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH1</accession>
    <name>A0A7W7WWH1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="38283" checksum="00EAD2290F42CAB2" modified="2021-06-02" version="1">MKIPFRQPDLVEEDRELLLAVVERIGRSAGPFVLGEHTARFEAAVCSSAGVRAAVACASGTSALALVLSASGVGPDDEVVVPAYGSAPPAAASLLLGAVPVFADVDPVTAVLDPDDVGRLLTARTRAVLPSHQFAVRTDTSALRRVAVGHGVPLIEEAAVNRPGTFGGPWTATGVLSFGRAKGFGLPGEGAIVVTDDLDLAQAVRVLRDHGRDGDPEVSVRIGASSRFDEVQAAFLLHRMDTWPRRLDRAVRIGGYYSERFAGLAGVVTPSPGSGPVYALHVDRRDPLRDHLAARGIGTHVPHPVPLPRQPVFAAHAQGDRDWPAAELVSRTRLALPLHPGLTDAEVEVVADEVCRFAQAGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX70</accession>
    <name>A0A7W7WX70_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytoene dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="525" mass="54576" checksum="0C18A3B26226FFB8" modified="2021-06-02" version="1">MGDEVDAVVIGSGPNGLVAANLLADAGWDVLVLEAADVPGGAVRTAELVAPGFRADLFSAFYPLGAASPVIAGLGLERHGLVWRRAPEVLAHVLPDDRCVLLSTDPDRTAASVEAFGVGDGQAWHAEVALWQRARAALLESLLRPFPPVRAGARLVGALGTAEALRLVRSFTQSVRAYGADRFSGVGAPLLLAGNAMHTDLGPEQAGGAAFGWLLSMLGQDVGYPVPEGGAGALTDALVRRLGRRVECGREVTGVVVAGGRALGVRDASGGLVRARRAVLADVPAPTLYLRLVGADHLPARLVHDLARFAWDDATIKVDWALSRPIPWLAPQARLAGTVHLGGDLDGLSASANELERGLVPTTPFLIMGQMTTADPSRSPAGTESVWAYTHVPRGGRWPADRLRRHADVIEDLVERHAPGFRDAVLGRVVQGPGDLEDANPSLVGGSINQGTAAVHQQLVFRPVPGLGRADTPVDRLFLAGSSAHPGGGVHGAAGANAARAALARAGLAGDAYRLLVDLAHRAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB1</accession>
    <name>A0A7W7WXB1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)H dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="1">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17479" checksum="E8F0A3741209B6FE" modified="2021-06-02" version="1">MTRALVVHESLFGNTRAVAEAVGAVLDARVVAVSDAPDVLPDDVDLLVVGAPTHAFGLSRPATRESADAPTTPVRGIREWLAALSPPGHLVTAHAFDTRMATRWPTGSAAKAVTRKLRALRFTVPRRPASFRVTGTTGPLLDGELDRATAWARTILAETSTRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL1</accession>
    <name>A0A7W7WXL1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="8">UPD</shortName>
            <shortName evidence="8">URO-D</shortName>
            <ecNumber evidence="4 8 9">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemE</name>
        <name evidence="13" type="ORF">F4559_004923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 8 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="12">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="27"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4967564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="37220" checksum="F81279AA3CB7768F" modified="2021-06-02" version="1">MSDYTDAPLLVAARGGTPSRTPVWFMRQAGRSLPEYRKLRAGTAMLDACLDPDMVREITMQPVRRHDVDGAILFSDIVVPLKIAGVDLDIVPGTGPVIAKPIADRRDVEALPALLPGQAQPVADAIGLLLKELDGVPLIGFAGAPFTLASYLVEGGPSKNHERTKALMHGDPELWHALLDRLADITGAFLRVQVDAGVQAVQLFDSWAGALSERDYREFVLPHSTKVLRSVTTVPRIHFGVGTGELLPAMREAGADVVGVDWRTPLDVAVRRLRAAAPDLPLPVVQGNLDPALLFAGLPALEREVERIKHEGRAAAGHIFNLGHGVLPDTDPDMITKAVELVHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM8</accession>
    <name>A0A7W7WXM8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31677" checksum="D8F938371FD29477" modified="2021-06-02" version="1">MNADRAARPSREVTTSTHVGAWVAPHPSGLPDLRIQMSEQVLKPPHCHEFMMRIVGGSSPLVPMISGPPEETAASGIMGGVLMARSEQRRLRQAQLYWVDEDMTSLALAAAATPSHEPVRARRMPAEAGLMLFAQPIGSHDVDLAAALTSPWTTAVSDLDEELRLAFPVVGVSWSRWSPADLDLDGEPGKIRWTPRTPQGAAPLTPEFDGVWLTFWTTGSNGWDSLPLDRPLAIDKHTGGTLTAVDMAAREAQAGLARLQTYDELVLRFDQPLPRPDPDNGSQWAHVVYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXU0</accession>
    <name>A0A7W7WXU0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11382" checksum="467B2EB9C4894E0F" modified="2021-06-02" version="1">MSEHPTGDLDDVVRQRDRLGILTIANEADRVEFGYLRSTLDRTAGNLSRHISVLEQADLVEAAKGYEGKRPRTWITISRAGRAAPAREMAVLRALLTRHDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ5</accession>
    <name>A0A7W7WYJ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative YccA/Bax inhibitor family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28143" checksum="7525E0AD8E4820A7" modified="2021-06-02" version="1">MRTTSNPAFRNLPTGGQQAGYGQQYGAPQFGGYQGAPPVQGERPITIDDVVTKTATTLAVTMVTGFISAYLVLTGAAQWYALAAPGCIVGLIISLVIIFKRTPSAPLVLAYAAFEGLFLGGVTGFFEGMFPGIAWQAILGTFGVFVAMLVVYKTGAIRVTPRLTKWIIGATAGAAILILANLVLSWFGVNSGLRDGSTLAIVFSLVVIGIAAFNFLLDFEAANEMIRSGVPSKWAWWAAFGLMTTLVWLYLEILRLLSYLQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU4</accession>
    <name>A0A7W7WYU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="25609" checksum="08BF532469A0399E" modified="2021-06-02" version="1">MDELSAADSDEVVRFLRRWYGDLDIGQVGTVSDLLGWPAFWSSLIDGRFSTIPVFGQVYIRENSGDFGGTTFWVDDEGDWEWSVPKIEEDAQVFERETGSSGSAWRSTGETMHRFLLHAALLGAVVEATDQYYARDVEVGLIPELVRGCSLVVSSESRCPAAAGKIFMGTETLIRVVDGDVGSTAPICDLVASSRSHSGVLNFISGLSHIPWKMYVRPTVRKFFPSEVPGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX2</accession>
    <name>A0A7W7WYX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031234329" evidence="1">
        <location>
            <begin position="23"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="103"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="564" mass="59549" checksum="CAAF6A9E517F5A36" modified="2021-06-02" version="1">MTRGIATRLLVLVGLLAVTACTATPPPPLVPSTPGMTVVPKEKLNEIVVGVDDVKGGYNPHTFAGQSTITTALASVLLPSTFRTAPDGGQVLDRTLLLDARVTRADPYTVTYTIRKDASWSDSAPVAAEDFVYLWQRMRSEPGVVDPAGYRLIDDIASREGGKVVEVTFAKPYPGWRTLFHDLLPAHLLKDAPGGWSTALDDSFPASAGPFSVKSLDRPRGEIVLERNDRFWEQPAALDRVVLRRASQHDIVGALKTGDDQAALVRADAIAMTDLAELGKATPLTITQVPRAEVVQVLLRPAAPQLSDVRVRTAVMSALDRDELIAIGSRSGPGAGLRADAQIVPPTKSGYRKTLVATDPAATARLLSEAGFSKPDNGQWSREGRPLNLTIAAPEGVEPYVTIATQLQRRLALSGIASEVRTTPANELFGVDLAGTATSNGEPPEVVDIAVVPLVDTGDSAAVLASAFGCRSTTGDPGTPIPANLSGFCDQSIQPVIDDALTGRLLLAEALATVEPVLWQQAVAMPLFQVTDVLVTLPVAQGVSAGAPFAGPLSGASTWRREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ10</accession>
    <name>A0A7W7WZ10_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36420" checksum="7AFB9017D084FDA9" modified="2021-06-02" version="1">MVELLEVRNLVKHFPVTRGVVFKRTIGRVRAVDDVSFTLSAGETLGVVGESGCGKSTLAQVLMRLEPPTSGEVTFEGSSLFKLRGAAVSRWRREMQLVMQDPYTSLNPRMTVGDIVGEPFEIHPEVAPKGLRAARVRELLDVVGLNPEHINRYPHQFSGGQRQRIGIARALALRPKVIVCDEPVSALDVSIQAQVMNLLADLQRQFGLAYIFIAHDLSVVRHLSDRVAVMYLGKIVEIGTEDEIYAHPTHPYTQALLSAVPVADPELRGRRDVIRLSGDVPSPIDPPSGCRFRTRCWKARDVCAEEEPALVVRGGHASACHFAEERSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ81</accession>
    <name>A0A7W7WZ81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA (Cytosine-5)-methyltransferase 1</fullName>
            <ecNumber evidence="4">2.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30350" checksum="3920EFEF8F71873E" modified="2021-06-02" version="1">MRPRLLDLFCCAGGASAGYHAAGFDVTGVDIVDQPHYPFPFIRADALTVDLSGYDVIAASPPCQLYSAATPESRRHNHPDLVDPIRQRLRDAVEHGDAWAYVIENVPGAPLIEPVTICGDTLRLGVRRHRLFESNVPLYGTPCHHDRDAPAVPVYGSYGQRGRNPVDGETSPGTATETARAAMGIDWMPWPNLTQAIPPAYTFWLGTQLIGHARRLAIPVTQATRTETSRAPLTDATGGKHHCRCGAPLTRPATGRWPRHCSPACRQAAYRARTKGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZG4</accession>
    <name>A0A7W7WZG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16629" checksum="6974B19D257B8271" modified="2021-06-02" version="1">MTSARDGGDVPPIPSIPLSAETPERIAGETSIGGLVRDATAHLSTLVRAEVELAKSEIAGEIKKAVKGSVYFIVALTVLLFSLFFFFIFVGELLAVWLPSWAAYLIDFGGMLAFAGFFAFLGFRKLKKLRAPQRTIESARDTVAALRHRGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXF1</accession>
    <name>A0A7W7SXF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="26" mass="3038" checksum="096D8DA9606618FE" modified="2021-06-02" version="1">MTTSRTQWLHQRRVTCVGDTTDDSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXG4</accession>
    <name>A0A7W7SXG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative surface protein with fasciclin (FAS1) repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="SSF82153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031307371" evidence="2">
        <location>
            <begin position="48"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="81"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="21283" checksum="6FDB06DAB1A43232" modified="2021-06-02" version="1">MRKTMIAAVAALAAASLTLTACSSDDTASTSSSTTSAAAGTSSTAMAASDGVTKTSDVFGPGCASVPQDPSNKGSLEGMVTDPVATAASNNPLLTKLVAAVKAANLVDTLNSQASLTVFAPADPAFAELGDAKFAELAADPAALGKILQYHVVAKRYDAAGLKAAGTVKSLTNQELKIAGSGDSLTVDGAPVLCGNIPTKNATVFVIGKVLTPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXS3</accession>
    <name>A0A7W7SXS3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">F4559_000263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4962904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="436" mass="47768" checksum="497FAFD5DA16C557" modified="2021-06-02" version="1">MLGAFRSALATPDLRKKILFTLGIVVVYRLGATLPAPGVSFKNVKQCVEQVDQQGIYSLINLFSGGALLNLSIFALGIMPYITASIIIQLLTVVIPRFEQLKKEGQAGQGKLTQYTRYLTIALAVLQSTGIIALAVRDQLFQDCQVPVIPDESIFSLCVLVVTMTAGTSVIMWLGEIITEKGIGNGMSLLIFTGIAARIPAEGQIILSRGGLTFFLVLVAALLIIASVIYVEQAQRRIPVQYAKRMIGRRMYGGTSTYLPLKVNQAGVIPVIFASSLLYLPDLISRLTASNDGSAPGWWQTFVQTYLVSQSNPVHMGLYFLLIVFFTYFYVGITFNPDERADEMKKFGGFIPGIRPGRPTAEYLRFVLGRITLPGSLYLGIVAILPNLFLDLTGQGQNQNFPFGGTAVLIMVGVGLDTVKQIESQLMQRNYEGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY23</accession>
    <name>A0A7W7SY23_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">F4559_000115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="159"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="27839" checksum="1F0716A48010704B" modified="2021-06-02" version="1">MTTIAVLGAGKIGEALLSGLLDGGRPAGDLLFTEKHAKRSAELTGRYGVEGVSVGEAAKRADVLVVAVKPQDIEPLLDQLVGDLAPGTLVVSLCAGLPTALFERRLPAGTPVVRVMPNTPMLVGEAMSAISAGRHAGEEHLDLVEELLGTVGKVVRVPESQQDAVTALSGSGPAYFFYLVEAMIDAGILLGIPRELAGSLIIQSAVGAATMLAEGGQHPVILREAVTSPAGTTIMAIRELEKHGVRAALLAAIEAARDRSVELGNAHEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYB3</accession>
    <name>A0A7W7SYB3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">APA family basic amino acid/polyamine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="496" mass="52043" checksum="B1D1A994B521C727" modified="2021-06-02" version="1">MPGNGLWRTKSVEQSIAETDEPDTKLRKDLTAWDLTVFGVAVVIGAGIFTLTASTAGNVAGPGVSLAFVIAAIACGLAALCYAEFASTVPVAGSAYTFSYATFGEFAAWIIGWDLFLEFALAASAVSKGWSLYLQTVLKHMGLDIKTTATIAGIDVDWGSLLLVAVLTVLLAVGTKLSSRVSLVITGIKVAVVLLVIVLGVGYIKLANYSPYIPPAAEGPDAGAGLEQSLFSLVTGYSGSTYGVLGVLAAASLVFFAFIGFDVVATTAEETRNPKRAVPRGILGSLAIVTVLYVAVALVVTGMVPYTALKTQADGSRATLATAFAANGLDWAAVVISVGALAGLTTVVMVMMLGQTRVTFAMSRDGLLPRSLARTGKHGTPARITYITGVLVAIGAGFFPAGKLEEMVNVGTLFAFVLVSAGVIVLRKTRPDLPRGFRVPLVPLVPILAIIACLWLMVNLTTLTWVRFAVWMAAGVVVYFAYSRRHSLLHRKDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYI6</accession>
    <name>A0A7W7SYI6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="20225" checksum="B9BD720D9F4B3579" modified="2021-06-02" version="1">MNRKVYIGLALLGVVLVPAAGVLSKSEHFGWSGQVGLAYGATVFPVALFMISRRVWPAVVGFVVGIVVGQVGLAFGLPLWLDLNAGTVSDCRVVEQRALSPRVGDVVTTVDCAGERFEIVPFRETSAYAVQVGSTTDLVVDRTGLIQPLLSFDVRPGEVTWPLPVAAVLPLALVLLSLRRRPTVGPPAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYI7</accession>
    <name>A0A7W7SYI7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031495694" evidence="7">
        <location>
            <begin position="30"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="180"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1081" mass="111625" checksum="CA9D0E457B91F17A" modified="2021-06-02" version="1">MINSGSRWRHRTSAALLAAVLGTTGFGFAAAPAVAQEAQGTPTAPADKQLDKQDRARVAEAEKAGKPNVTLLVAAEPGKVDTAVNELKALGGVVESTERDVEYVKVSIPRDKAEKAAKLDSVQAVDVDGLVALDNPRPEGSQAPLPQKAPDAKTPRKNPYMPIQDTLAAEFLQDHPKWDGRGTTIAILDSGVDLDHPALKTTTTGETKIVDWYNANATNSGDGSWVQVAGRYNGSFKVGATTYKAPATGGPFSFGNFAETAGDFGTAASETGGDLNRDGDKADSFGVLQDVSTKEVRVDVDQDGDFTDEKPLIDYKYKKDVGHFGTDNPATPVLDTVAFVVQTDRSIYDNAGTAYVNIGIAGAAHGTHVAGITAANGLFGGKASGAAPGAKLLSVKVCLSTPSCTSSGLIDGVLYAARNGADVVNISIGGLPALNDGNNARAELYNRTIAEYNVQLFISAGNSGAGANSVGDPSVATDAVSVGSYITDDTWLSNYGSVTKQAESLHSFSSRGPAEDGGFKPNIVAPGSAISTIPQWQQPGPVAGTYALPAGYAMFNGTSMAAPQATGAAALLVSAYKAVHKNEKPTAYQLRNAIYSSARFVSTLGAYEQGAGLFQTSKAWESLDAHENTQAVTTAVAVNTVLAPLLKTPGVGVGIHDREGVKAGSSYTRTYTLTRTTGPDTNQQFHVKWVGNDGTFTSKALVSLPLNTPVQFEVKVNPKKSGVHSALLKLDNPATRGTDVFTLNTVFAADEFTAAGKFAVTKTGELPRNQSHRFWVTVPAGTSALKVDLTGGGDAGKGQIRFLRYDPYGVPTDANSSTNCYIPDAGAGCATGAANSRTVSNPLPGVWEIVLESRRTSDADLTKYSVTASVLGTSISPNPDKLASVTAGTPVDRSYTVTNTLASFTGRLAGGALDSAKIARPSIADGTSQVYDVTVPAGATSLTATIGKPADISADLDLTVYNCTTGSCVQAGQQADGDSEESVTLANPAAGLWKVVVDGYAVPAGTTEYDYIDVFAAPGLGTVTVTDSDANRAAGASWTVPGTVTATGQPGAGRVLRGELTVRAEGGAVVGRGAVIVENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR2</accession>
    <name>A0A7W7SYR2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="30360" checksum="1A9DE4CBD258F989" modified="2021-06-02" version="1">MSVNQLPAPDGGVPSRVWFVTGTSSGLGRAIAEQALAVGDTVVATARKVESLAGLMALAPDRVTPLPLDVTDGNAIANAVQDAIMWHGRIDVLVNNAGHGFIGAAEETPDAELRDMLEVHLHGPVALTRAVLPHMRARRSGAIVQMSSMGGQVVWPGFAAYCTAKFALEGYSEGLAAEVASFGIKVLIPEPGAFRTGFAGAPLRFGAPLPDYRAVMDPVRALVRDMDGTQPGDPAKAAAAILAALDSDRTPLRLPLGPDAYEAITGRLAGLQDELTTWRPTSVATDVDQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX6</accession>
    <name>A0A7W7SYX6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14166" checksum="773CCA918EF56C94" modified="2021-06-02" version="1">MIIYIESSATNHLAPAKDSLQELVDSWGFTLHEVPATALGTSDSTREDDKSVDPVALAALVLSIPSAALAVTDLADRIHKRRRAKDIIDKARQIADDHSVTLKLDTQDGPQDLSTLDPDQLLDLPESDDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ21</accession>
    <name>A0A7W7SZ21_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10630" checksum="89DA7F81711F8182" modified="2021-06-02" version="1">MTTLTPLLILTVVLGLLALVLRWAFGSDRRGVPDHTGTDFGLLTEVAVVPTPEAAQVLASRLRRSRIRVTVVNRDHGHRLLVFPADAAEARLVLRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA2</accession>
    <name>A0A7W7SZA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="28003" checksum="9C8498B36F1B3616" modified="2021-06-02" version="1">MTQPQLLVSTGDATTGTPRYSLLVARDGAEVVAAQRLRHRVFAEEMGATLHTTAPGLDVDAFDEHCDHLVVREDDTGEIVGTYRMLPPDRAAAAGRLYSDTEFDLTNLADLRPSIVETGRSCVDAAHRNGAVVGLVWAGIARYMLLSGHSWLVGCASVPLHDGGSYAAGVWDQVHAKHYAPERYRVSPLVPWDVDSVERPARTVLPPLLKGYLRLGAWVCGRPAHDPDFGVADLFVLLGMEHVDQRYLKYFLGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB3</accession>
    <name>A0A7W7SZB3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20533" checksum="BA9C0FEA1E2B43A5" modified="2021-06-02" version="1">MDTPEILRRSFPDWDVETDHPAAYVSETGDAVQALMYSYLIWPALIERHGAVFLALDGNESEDFAERMGRPTPFVHPDWPALSWVDYVASFNFYEVPHLFRMLRGPAEVYDPSHEALGVVLREAWAARLAAAYPDRRFAVDLLENDGTMALRIVVRQTFPELVAPEGYDPRRRGIIAGPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG8</accession>
    <name>A0A7W7SZG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16816" checksum="429486EA61A4F100" modified="2021-06-02" version="1">MAQYTITRTCGHEDTINITGTNVRNQHRGEVRRQERRACLACHTAAEHRAGARVTADLDLPPLTGSTKQIAWAEAIRGRAAPAVERHVEELVASIGVNGFTPAFCDVWIDAMREVLTGRTDARWWIDHSDDAAEAIYRIGAAALRAVVYPDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM2</accession>
    <name>A0A7W7SZM2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">F4559_001265</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBB4963906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="32120" checksum="F927FBDD2958449B" modified="2021-06-02" version="1">MPELPEVEVVRRGLHEHVAGRTITSVEVLHARAIRRHLPGAADFAVRLTGQRMEAARRRGKYLWVDLSGGDALLAHLGMSGQMLVQPVDAPDEKHLRVRLRFDDGGPELRFVDQRTFGGLMVADLVEVDGTSLPDEVAHIARDPLDPEFDLSAAVRALRRKRTEVKRALLDQTLVSGIGNIYADEALWRTRLHGLRPTAKLTAAQGVELLGHATEVMREALGQGGTSFDALYVNVNGQSGYFDRSLAAYGQEDRPCSRCGTAIVREPFMNRSSYSCPRCQPRPRSAVRPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T061</accession>
    <name>A0A7W7T061_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase (NADPH/NADH) small chain</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
            <ecNumber evidence="7">1.4.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001536</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EC" id="1.4.1.14" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="38"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="155"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="501" mass="54089" checksum="C1521F60D8FB3428" modified="2021-06-02" version="1">MADPYGFLKNTRADAKKRPADERLGDWREVYAAAPVEVRDAEVRTQATRCMDCGIPFCHSGSAGCPLGNLIPEWNDLVRRGDWAQASDRLHATNNFPEFTGRLCPAPCEAACVLAVSDMSGGAVAIKRVEQAIADVSWEQGLVQPSQSQVSSGRRVAVVGSGPAGLAAAQQLTRAGHEVTVFERDDRLGGLLRYGIPEFKMEKKVLDRRLAQLRKEGTRFVTGCEVGVDLTVEQLREQFDAVVLAVGALRGRDDRTTPGRELDGVHLAMDHLVPANRACEGDGVPEIDAAGKYVVIIGGGDTGADCYGTAIRQGALSVLQLDQYPQPPSRRDDTRSPWPVWPWILRTYAAHEEGGERRFAVAVEEFVGDPDGHVRQIRLRKVRVEKDASGRRTVVPTSEEAELLPADLVLLAIGFEGVERMPLLDGLGIPLTARGTIGCGSDWQTRAPGVFVCGDAHRGASLVVWAIAEGRSVANAVDRYLTGSSNLPSPVIPNQLPLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T067</accession>
    <name>A0A7W7T067_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 12">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpE</name>
        <name evidence="15" type="ORF">F4559_001527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="14">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="13">
        <location>
            <begin position="237"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="513" mass="55326" checksum="99FBD76AE3E0DEC0" modified="2021-06-02" version="1">MVSVIGAGTGLGEISPTREEFRELAAHRRVVPVVRRLLADAETPVGLYRKLAGDRSGTFLLESAENGRSWSRWSFVGARSAGALTATGGEAFWLGTRPVGLPEGGDPLAALRETIEVLRTDPLPGLPPLTGGMVGYIGYDAVRRLERLPSLAEDDLQVPELVMLLATDLAALDHHEGTVTLIANAINWDDSPERVDAAYDDAVERLERMTLDLQSPAPPTVAVFSRPKPEFVRRRSQKEHYAAVEKAKAAIRAGEAFQVVLSQRFEMPTSADALDIYRVLRTSNPSPYMYLLRLDDFDVVGCSPESLVTVRDGKATTHPIAGTRWRGVDDEEDALLEKDLLHDHKERAEHLMLVDLGRNDLGRVCKPGSVTVVDFFKVERYSHVMHIVSTVSGELAEGRTAFDAVAACFPAGTLSGAPKPRAMELIEELEPTRRGLYGGVVGYLDFAGDADTAIAIRTALVRDGVAYVQAGGGIVADSDPVAEDNECLNKAGAVLSAIATAQTMAPAVDPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T080</accession>
    <name>A0A7W7T080_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MerR family redox-sensitive transcriptional activator SoxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01110">
        <property type="entry name" value="HTH_SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010211">
        <property type="entry name" value="Redox-sen_tscrpt-act_SoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30204:SF0">
        <property type="entry name" value="PTHR30204:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01950">
        <property type="entry name" value="SoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17017" checksum="50BD4B3D906BAC14" modified="2021-06-02" version="1">MSKLPDMLTIGQVAERSGVPHTALRFYEERGLISSERTAGNQRRYPRTVLRRLAFIRTAQRVGLTLEDVHAALATLPEGRTPTKTDWHRLSTTWQTELDARIDALHRLRDRLTSCIGCGCLSLRSCFLTNFDDKLAADGPGAPRLKPSSEGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T083</accession>
    <name>A0A7W7T083_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="17550" checksum="49AFD72F55972797" modified="2021-06-02" version="1">MSDGIHEAPEAQPARRRLSPNLVLAASGVATATIFAAIASIAGPSEQAAPAKPTPREDVVNRGQLTVTSTRGTTAGTTVTTTDTTTATTTTGEDAPTTTTRARITTVTRPDGTTTTVEEPDRPDPKPTTQPPRPTTTLPPPTTTTTTQPPATTTQPPATTTTPAQGVITQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0B8</accession>
    <name>A0A7W7T0B8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisB</name>
        <name evidence="7" type="ORF">F4559_001509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21711" checksum="25823C51F8E9EB6C" modified="2021-06-02" version="1">MSRVGKVERSTSESSVYVEIDLDGSGQVEISTGVPFYDHMLTALGVHGSFDLVVRATGDVEIDAHHTVEDVAIVLGQALREALGDKRGIRRFGDCWIPMDETLAHAAVDVSGRPYCVHIGEPEQFNAFTIGGNYPFVLNRHVFDSLAFHAGIALHVRVEYGRDPHHITEAEFKAVARALRAAVEPDPRVGGVVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M8</accession>
    <name>A0A7W7T0M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19237" checksum="DB8B86FF5A911897" modified="2021-06-02" version="1">MASDLQRKKTALVFTAMDVNGDGFLERRDFDALAERWSALRGGADTAELREVLTSWWYALQLVTDADGDRRVTLDEAQSVSDRLAEKKGLVMATARSIFDAVDEDGDGRVTAAEYNQLIQAWTGRAAFTDDVFRLLDLNGDGTLSKAEFQRHWVEFWTGDDASAPGTHVFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y5</accession>
    <name>A0A7W7T0Y5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="34273" checksum="C710C536CEE5112C" modified="2021-06-02" version="1">MPDLDPARLVQARELAGLSRRGLAELVGVSATQLCRYEAGASHPSPDVVRGLARTLDVPAAFFRPGRPHVRLPVSRRPAAAAFAEQAWELAHALEGHVRLPKVRLPRPAVDTVVAARAVRSLWGLLPGPVAHLVRRLESNGVVVLFGAEPFATAVPDRPVVVVPRDPDVYGHRFTVARELGRLLHPDPTEHDLDVFAAEFLTPRAAITPELPDRVDLDRLGELRAVWGVPVLALVRRARELGVLSDAAGTRGLRRLKITELSPEPVTGYPGERPALLGRAFGMSGLTAQALAAELGWRVSHVRSMLGIERPLLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z3</accession>
    <name>A0A7W7T0Z3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalt/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="230"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="263"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="468" mass="49894" checksum="AF36979198C91F8A" modified="2021-06-02" version="1">MNAALYRPGDSPVHRLAPQVKIVAAVVAVLCVVATPREAYWAFGAYLLAIGAVWAVARTPVGWYAPRVLIELPFVLLAFVLPFTGTGERVDVLGVSVSVSGALAGWNILAKGTLGVLVSLTLAATTAPQDLLAGLGRLRMPAVLVTIATLMLRYAEVVVAEAKRMRVARISRGDDPRFLWQAGATARGVGALFIRSYDRGERVHLAMVSRGWSSVPSPEVSRPVRTGPALVVERLAFAYPDGHQALFGVDLRVERGERVAVLGPNGAGKTTFALHLNGVLGGGSGRIEIAGLPVERANLKEIRRRVGVVFQDPDDQLFLPTVRQDVAFGPTNFGVSGPELAARVEAALAAVGMTEAADRSPLHLSGGQRRRVALATVLACDPEILVLDEPSANLEPVARRELAEVLLGLDTTMLMITHDLPYAAQLCPRSVLVDGGVVVADGPTREILGDAELLARHRLELPYGFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D5</accession>
    <name>A0A7W7T1D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="34351" checksum="4F3C5840E9195549" modified="2021-06-02" version="1">MSRDAIRGFGLAVSFAVLVLVMLASLWIGTKDIPFTDTWRLLFADDGTGDAALVRAVRVPRALLGVLAGAALGLAGALMQSLTRNPLADPGLLGVNMGAAAAIVTAIAFFGVTHPTGYVWFALVGAAIAATACYVLGASGRSTPTPDRLVLSGAALTSVLYAYVSGVLLLFPHAFDSFRFWNVGSLAGRTFEIIGQTAPFILPGVLITFLLAKSLTVLALGDEAGRALGAHAGRTRAFGILSITLMAGAATAAVGPIGFVGLTVPHVARMIGGTDQRWVLAYSAVLAPILLLVGDVVGRVVIAPQEMEVGIVTAFLGAPVFIALCRRRKLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M9</accession>
    <name>A0A7W7T1M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioester hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16221" checksum="3533FC0B13F76FB4" modified="2021-06-02" version="1">MADQRPAHVHRVRVRPADCDRQGIVHSTRYPVFFEAAMVETVRALLGSYHELAKQGVDLHVAESGVRHLNPARFDDLLRISVRVRTLGTTTLTLGFDAAVDDTPVATGWNRYVSVGTPEAHSAPLPDGLRRLLEPRRVPQPRGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z1</accession>
    <name>A0A7W7T1Z1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9539" checksum="93C5FB617D928D5E" modified="2021-06-02" version="1">MSTSVSDNPDQSRYEITDGGDLVGFVDYTRDGDEVVLTHTEVHVEGKGFGGTLIRHAVLDLRGQGATVVPECPFVKSYLDKNPDLTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T213</accession>
    <name>A0A7W7T213_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="26058" checksum="8398C723B6580196" modified="2021-06-02" version="1">MGWKFVEPSKDPRRPLRIYRATTAEHLDRVDLLWKEVYGRECGWLAAGAGTPRTDGFHPHSVYLLADVDGETVGTMRLVRDSPEQGLPVGRFLPVADLKGPVTLECQRLMVLAEHRRRRWPELPFGVLAALIKACLHWCVRTDVTHVLADVFLDTATTPMAPLVELGFAETGRTFVDTELHEPSKSTVLVMRINELVSRSFRADNPFYRYLMDFDPIIDLTPLGTADHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F2</accession>
    <name>A0A7W7T2F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012788">
        <property type="entry name" value="Decarb_PcaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02425">
        <property type="entry name" value="decarb_PcaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13141" checksum="4BC31F95175995CF" modified="2021-06-02" version="1">MNDGERVRREVLGDEHVDRARARADDFTADFQDLITRYAWGEIWTRPGLDRRTRSCVTLAMLAALGHETELEMHVHAALRNGLTRDEIKEVLLQVAVYAGVPAANRAFAVAQRALGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H1</accession>
    <name>A0A7W7T2H1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="571" mass="61202" checksum="58885F2B707A2DFF" modified="2021-06-02" version="1">MTDVDRRVAASRMIGHDHTVLGEVIAAQGVLLRASDPDLVALARLAVHRTSLHLHNDWIPERLPAVWAAVGRFDHAEELAGSVSQFFGAGPLVGLAETAMTMGDRDRASRVLDAIGNSGSRARLCARSAHMALDRADDGDAAAWYAESESPMAQRRDDYDAETLAHVAAVAARLGRTAVAATHCAGIQGRLAHTSEWTTESGDGEPDRSEPSDTTTLSRIDANEASAVAAALGRGGLVDHAWSVTSEIDDPEYREYALFDVARTLAATDPDAPEEFARHTGAVEYLAARLAGVAVVAGRRSERQGVDRPFAEVDAALRRRPDSAEREYVTRASAVALASVRYDERVEAAVAGLLSAGDIGGAVGVVSALARRAETGHATRLIASVEQAARTASTGIDDERPRWWAEVLVDFRDFDRAEHLIRSFPSAGARAESLASLVEGLLADGAVDRAELLLAEITTVGAQRRPRLELIRALLDRDRPDRAVRQARSAPPPLHRAAALTLVAVRTRRLDPLDEALATVQDTTDHDTRMKVVATILFVPRPNSATVRASWSCGRGCGPPPPGDRDERPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U2</accession>
    <name>A0A7W7T2U2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009000">
        <property type="term" value="F:selenocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="5">
        <location>
            <begin position="65"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="445" mass="48404" checksum="94364D15C05BF489" modified="2021-06-02" version="1">MPDEARLARWVNEFFGRLTQEPTTADRRFYFVDESPPGVADAFDVAAIRRDFPILRDKVNGRPLIWLDNAATTQKPQVVIDRLAHYYTHENSNIHRAAHTLAARSTEAYEHARETVAEVLGAGDSRTIVFTRGATEAINLVAETWGRHNVRAGDEIVVSHLEHHSNIVPWQRLAESTGAVLKVAPIDDDGQLRLDAYEDLLNHRTRLVAIAHVSNALGTVVPVAEVIAAAHRVGAVVLVDGAQAVAHLPVDLRALDADFYAFSGHKVFAPTGVGVLYGKPELLAAMPPWQGGGNMIDDVTFERTTYRPPPNRFEAGTGTIADAIALGTALDYLRGLDLGSVERYEHGLLDHATRQLGTVPGLRLIGTAPEKAAVLSFTVDGHDPVDLARSLDQGGIAVRAGHHCAQPALRRFGLEASVRASLSLYNTYEEVDALTAELHKLAGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T333</accession>
    <name>A0A7W7T333_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="17389" checksum="BAC4E086BA3931D4" modified="2021-06-02" version="1">MSEMRVVGVRVELPANQPILLLRETEGERYLPIWIGSVEATAIALEQQGVRPARPLTHDLLKDVIGALGRQLEQVRITDLQEGTYFAELVFDGDVRVSARPSDSVALALRIGVPIHAEESVLAEAGLIIPDEQEDEVEKFREFLDSISPEDFRGADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T396</accession>
    <name>A0A7W7T396_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026337">
        <property type="entry name" value="Mod_HExxH"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04267">
        <property type="entry name" value="mod_HExxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="34963" checksum="CED14F7AF5559EEA" modified="2021-06-02" version="1">MSATAFDRVLPAEVADRVDRYRQEKIDRLDSVLRDLPGCRPWGDVAAEDLPLRYALAHHVFEGVSRAAEQGDAERVADLLRLRADQSALRPAHEAGGPVLVADPPRSAFTDDRALAASPVALVDPVVAASASPAVRDLVSHALATAVDSGFGATVSRNSRVVVLIARRRATDTSIRSWTTNALPATVHLDYFAEHEYVGRDLIHEAAHTELNDLFAAHGVALPDEVAYYAPWLETERPVFGFLHGTWAFSHVALYCEWLAGAAVPADVRALASAMHAKYAEHMHQARSDFDRAIRWVRAEPVAELITACRDRVLGSFDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3F6</accession>
    <name>A0A7W7T3F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22848" checksum="2FA21C928E656A8E" modified="2021-06-02" version="1">MSSQDVTRTKPLRADARRNRSKVLQTAREAFAIEGAAVSIDEIARRAGVGAGTVHRHFPTKESLLETVLEERIAEIVDEARVLVDEPDPAEAFFGVLRLLLRHGTRDRALSDALAARGDNCQAATFVVTGARRDLQIVLTGLLHRAQAAGSVRADLSLMELHALLSGLHLSMRTADEALVGRLLEIVTDGLRGRRAGAGQDRDPARIGTPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V6</accession>
    <name>A0A7W7T3V6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="27718" checksum="AAC888BC031F428B" modified="2021-06-02" version="1">MRRFPRVGVWAGGAVVVLLVLAAVAPGWFTSAAPLEADPVNALLAPDGTHWFGTDELGRDVFARVVHGARPSLSVGLGAILIALTAGSLIGITAALGGNVADSVLMRLADILLSLPELMLALLVIAVLGAGTGNTMIAIAVALIPGYARMVRAEALVVRRSGYVEAAVGLGLPRPVLIARHVLPNALGPLLVLGTVGFGTAIIAVSGLSFLGLGARPPAPEWGAMLSSGRKFLAVAWWTAVFPGAAITLAVVSVNVVGRRLQAAFTRRTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W2</accession>
    <name>A0A7W7T3W2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF1800 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014917">
        <property type="entry name" value="DUF1800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08811">
        <property type="entry name" value="DUF1800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="45624" checksum="1F3CAA2B25CCE966" modified="2021-06-02" version="1">MAELDERGLVARLHDRFGFGPRAGDLEVGVTATLDRLLGDGGADGPEPPKPGAPVKAGDDKQARKEANKRRAADERQLVLWWLDRMVAADVATTERLTWFWHGHFATSEQKVRDPRLMLAQNATLRRQALGPFAPLARAMVVDPAMIRWLDGDDNRSGVPNENLAREFLELFALGIGHYTETDVREAARALTGWTVDRDAGTARFVAKRHDDGVKEIFGAKDDFTAESFVDLVLARPESAAFVVDRLWFRLVSTTPPPDDARRRLVAALSTDVRSVLRAIAAEPVFRDRATTLVKQPVEWLVGLMRALDVRPSKLPERAVTALGNGLRGLGQLPFRPPSVGGWPADAAWLTTAAGVTRLRVARLVAAHADLPRDVDGVGRLLGVAEWSDRTRAALGRVSDPDEVAALAACAPEYVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A8</accession>
    <name>A0A7W7T4A8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17049" checksum="91676232D8826995" modified="2021-06-02" version="1">MGREVSGFEFAEGDVEIARAVVDARYPRESEIFDDTLDDFVLDPERTVRGVRLGAPVGIGIDLVSVTPYVLSAVGFLGGMVAEKVVEDAYGAVRDRVRRAIVRRREGRAPEAVDAAEAEQVRVLVVVHLVGQGAEQTVAEDVARHVVVEALGHDIGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J7</accession>
    <name>A0A7W7T4J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30301" checksum="4F1E8C22FD0C67D4" modified="2021-06-02" version="1">MSVSVDDHLVAGRYRLDEADRGREIRRAWDTLLRRPVALRFVDSSPGVENGIRTLAALQHPALPQVYDAGAGYVVTHYAGPRTLAGTPPLPLPEVRRIGVRLADALAHLHSYGLVHRDLQPATVRIDASDEPCLADFSPWSGVQGVGYLSPEQVRGQRIGPASDVYALGLVLLECLTGHQEYGTPEERLRRPPVVPRTLPPGVVRELSLMTALSPRRRPAAGECARRLREVDLTRVGGRVGRRLAAASVTAVLGLGGALWASHSASPTISAPAPDSSVAHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q4</accession>
    <name>A0A7W7T4Q4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase (Nitroreductase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14972" checksum="1992B91F74A9B1A1" modified="2021-06-02" version="1">MDERIVRNQAVIEEFRANGGVVGGAYEGRDLLLLHHQGARTGASHISPLCYLPAGEALVVVAANGGRPNHPGWYHNLVARPEVEVEVGADRRSATARIAQGTERDALVQRFHQETPFFTRFADAAGREIPVVVIEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T552</accession>
    <name>A0A7W7T552_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="46"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="146"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="40145" checksum="88FEBE24BAC5F83D" modified="2021-06-02" version="1">MRYRLSDGSLRSETGFATRGDAEDRAADIESDQRRGRFVDPRLAQTSVGEWVTQWVDAHDVSGVTEATYDSHLRNHILPRFAATELGELSRMTIKAWAKTLRRSLSDRSVADVVGLLSMILGEAVDEGLIGSNPCRKLRLNAGDQPERPHADADEVTAIAGRMTSPANAALVVTAAYTGMRWGELAGLQWDRVDLDKQEIRIDAKDGALHELRGRLELGPPKTPASVRTVHLPTFLTELLAEHRCDTPARKFVFTGIDGGLHRRSNFRRRFWLPALHGDTTLGWTPIKPHMHFHDLRHTHKTWLIEDHVPEVLQHKRIGHKFRGVMGVYSHVTRPMIDTMLQGLQARWEQYGSRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H5</accession>
    <name>A0A7W7T5H5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="15991" checksum="C6CE1DA74B429197" modified="2021-06-02" version="1">MLLLDEEFHGAGQASWTNYREGDVVHSGDITGAADGASEFIDVPLPTTRAAYVVPRVNIFAGESFDDVAESMFGYRLRNADQRGTPFDPGPCASARGCAARAGSSCRWCSRTPGRPVGPWACFLPTFTHSTPALPTGRGQRSPSSHSGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N8</accession>
    <name>A0A7W7T5N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF2252 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030609248" evidence="1">
        <location>
            <begin position="26"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="446" mass="47926" checksum="9F0231D4261B8767" modified="2021-06-02" version="1">MRRVVATAVVTTVVTSLLLPSPAVAAPALTRDPVDVIYARDHALHVLNNGATDDELTLRTEKLAGDAWSFFRGTSPLYYRDLGELPASAYASGTAWLTGDAHLENTGADRGSDGTEQYQLTDTDDAWPGSWTWELRREAVSIVLAGRANGRTPSQIATDVDTFVAEYAQWIDKFHGTNDEATYRLTKSNTSNLSEDLIDKSDDDTRADLLAKWTSGGQFKSHPELLPVTASTRASVVSAVAAYRTTATTPLSASRATVKDVRRRIGAGTGSLGRSRWYVLVEGDTTSASDDRILELKQTVDPAPKPLAPGASTLTGGERPAKALRWLVNRSDPLAGWASVGSVPVLVKEKSPYAEDLEIGDLDSSTVWDDTVRDVARLLAAAHSRADQDIAGTGLTYSVDAAIDAAITSVSGLQSETRTFAFSYADQVTTDWQAYVVAKNSGRPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V2</accession>
    <name>A0A7W7T5V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32624" checksum="653E949CA11C6F03" modified="2021-06-02" version="1">MAYRVFELVKRFPRQAVAAVDGMSFEIGEGEIFGLLGDNGAGKTTLVRQLTGLTRPTSGTVELFGHDVVTDPGFVSTVVGYMPQSGAALNRLTVGEALYFAGHLRGLSTRDARRERDDLVDLWHLGPSRNRVAALLSGGQRRLLQLAVAMAGRAPVLILDEPTNDLDPVNRKHVWDVLRDWNKRLGTTIVLVTHDAVEAEKAIQRVGIVQKGRFTALGTPAELKAGIALKLKVELSFPPDLPPSLPVGVVPQEKDSGTWHLVLDRREAAELLAVLDLGRVSDIRLTSTTLEDLYLHYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T605</accession>
    <name>A0A7W7T605_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="414" mass="44002" checksum="6E40C9B0ADF08AEF" modified="2021-06-02" version="1">MIRIGNASGFYGDRFTAVREMLEGGELDVLTGDYLAELTMLILGRDRLEDPTQGYARTFVRQMENCLGLALERGVKIVSNAGGTNPRGLAEAVDRLGLGAKVGYVTGDDLRSRFPDPLTANAYLGAWGIAECLRAGADVVVTGRVTDASLVVGPAAAHHGWGREDWDRLAGATVAGHVLECGTQATGGNYAFFTELDLSTPPGFPIAEVHEDGSALITKHEDTGGAVTIDTVTAQILYEIGDPAYPGPDVVSHFDTIRLDADPRGVRISGVKGSPPPEELKVALNSLGGFRNSITFVLCGLDIEAKAALARRQLEDLVGRTDLSWTLARTDHVDADSQEAASALLHAVIRTMDPKRAKAFSRAGVELALSSYPGFHITGPPGDGSPFGIFRAAYVLRDEVRHQAVLPNGEVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T611</accession>
    <name>A0A7W7T611_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030742671" evidence="6">
        <location>
            <begin position="25"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="139"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="510" mass="52107" checksum="47B1419F6BAC054E" modified="2021-06-02" version="1">MTRAFGAIALTAGALSVATATAGAQPASVVPAPEGTAVPGQYVVVLKDDAAVSASADLTARHGGKVTATWNRAINGFAVQASEDEAKRLAADPAVKTVVQNGRVQKTDIQTNPPSWGLDRIDQRNLPLNSGYSYTTQASNVTVYVIDTGIRTTHSTFGGRASWGADFIDGTKVDCNGHGTHVAGTAAGAEYGVAKGAKVVAVRVLDCQGGGTFASVLSGIEWVTANAVKPAVANMSLGAVAGTQTEPIEQAVRASIASGVTYAVASGNANTDACQFSPARVAEALTVNASTVTDQRAVFSNYGRCTDLFAPGEAIKSAWIGGDNATETIDGTSMASPHVAGAAALYLGANPNATPAEVGTALLGQTTPDKIGNPGAESPNKLLFNGGGTPGATVVLTRYQKAPDHVSTVNGAPGEGFVTEGKLGKLFYGQEPNTHAVYQCRSDWDYFTSANAACEGKTVIATLGYAFNSAQANSRPLYRCQVKGTGDHMDSASSTCEGQTTEGILGHVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T621</accession>
    <name>A0A7W7T621_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="643" mass="67483" checksum="58FB6FF78049ED6F" modified="2021-06-02" version="1">MLAEALELASDATERTATSINLAAVVDDATALELLTGLAGATAAAARAQLLARAGRVAEAWQDVESGLADASPREETMLRIVRTGLFMLEGRLYEAEDEATRSVDLARAHCPDLLAHPYENLAAIADAVGDHAAATAYRAAARDDVRSWDDLNARAIAFAEAGDRANAARTFEAAYRATLDSDDHTTSCARAVLAGNLAKNAPDSAAAVDWATEAITLATALRPDPNAPVDLADVLVKALSDRAHHLRHLSRFDEALADVEAAQGIHARPALRALKASVLVSAGRFAEGAAEARAALDLAYAQAPEVAAAVHATLAELADATGDRIEAAEQHGLARALAAAVDDPVTGCTAVLGLARLAYLEGDYSRADVLHAEAEALVGTDPAILHGRAVVAIGRGQADEALRLLESMPADGAGTPIRAITGHQLRGLAAATAHRYDEADDRYARAVEVAERAGLWHVVIGASWWRAESLLRWAVHTGETAGALSRRALDVALPAALAAEAVRHRFPHGPLRERWISLAAAPATRTALRAIGALGEGELAAAYLDHVSSPVSFAGPVSFAADEAEPGARAEIAALPPPTAEPDHLPYAASAFLLTETEVPGFALPPRVRPDPRTRTPLDDWIDLAERRYGFPVRGEGVVSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T754</accession>
    <name>A0A7W7T754_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MGT family glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UDPGT" evidence="3">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="373" mass="40876" checksum="531FC2E24BAA17B5" modified="2021-06-02" version="1">MSHIAFFNVPAHGHVNPTLAVVVELVSRGHRVTYAVPEEFHDAVRHVGATPVPYTSSLPTGDQEWPEEAAPAMALFLDEARVVLPQLEAAYAADVPDLVVYDIGAWTARLLAARWGVPAVQFSPTFVAYEGWEETLADPDVDRFFDVLDRWLAEQGVDTPGRDYVGRPDRAVVSITRTFQFQSDTVDPLYAFVGPCLGDRSYQGGWQPKGRTLLVSLGSAFTNRLDLYRNVVEAFGDTDWHVVLNVGRLVDPALLGDLPDNVEVHRWVPQLAILAHASLFVTHCGMGGTMEGLYHGVPMIGVPTIGEQHLNAQRLVELGVGRHLPDPSIEDLRTAARELTEDPDVARRLAELRQEAREAGGARAAADVLEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T772</accession>
    <name>A0A7W7T772_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="79"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="29860" checksum="C30A9C6105141C40" modified="2021-06-02" version="1">MTIEQVVERLRDGQGKWSRSKLGRIETREQGVKRHEVEELLDLYGVYDPTIRPWLLGLVSTVNERGYWLALRKDLPSDFHEFLGVEAALVRLREFETMVVPGLLQVPEYTRALIYGANPGLERDLAEGRVQARMARQQVLNRTVPLRLHVILDEAILERPVGSAAVMRDQLQRLIDTGAENHVTVQILQKSAGASPALDGPFSLLTLPAPIPDFGYAEGQGGAVYIEDVDHVRECAQRWGILTGKALSAVDSLDVLREAVNTYDEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T799</accession>
    <name>A0A7W7T799_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5997" checksum="89972BCE05021AF1" modified="2021-06-02" version="1">MPTMRDDNPENQPVPNRRERRGKGKSEAVTALPGRTLRSSHVPRRVAFRRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K2</accession>
    <name>A0A7W7T7K2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="623" mass="69945" checksum="10A5BBCCA303F157" modified="2021-06-02" version="1">MRIQPRRQILDIWRSVVKSSYRDGAWQWGGREDSNSLSDAEQLICLLYPATEVSALALEQPDVIAEDAAKALERLGEPRVVPFRVVELVEEYLERHTRDGEPYFGGGGYLGTDGDEPPTERQLALGLVDSYSLSLTLCLAALGFLNVYKPHAARRPALVSRIETIQAALSRRLTAAQIGLLRSFVVNTVGLDDRDAPVRSAMLAMVNQGDDPDPVVVNRLRERLQRVRTRLLDDVRVGVSTDRTLEEESRLFEIGWGWSIVRDATPVELDLERSAFDRQPTIGSVQGVAHSRPYLYSTVVALDGINDLRSARTRELNLLDDEQRRLTEALQIRWDLTQRYWSTIARFGKTWPLEDIPWRTSDGEESDYYSLLVSAVLVQDLEARQATDDDLNRAVAVFEALAQRGRITRRVTQDDPSVAMHVPGVRMTLGGSADIGPQLYWYARDFAPLLLKRCLQAAALSVNRNARDRLMRLAETTMDHLERRRIRDGDAPGLWDNPAAVLFGDGAEAVERRPSWYMTERVVEALITGARTFEERPLRSASMRARAEDALHEAEHLLNRLLLNSDSDDTSARSAELTMIERRLSRAREVVTERPGTANALALAALLSLDEMDVAQNDASRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V1</accession>
    <name>A0A7W7T7V1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="31231" checksum="F78C53D94D778882" modified="2021-06-02" version="1">MPEIRARMTDWARDPTLDGADNWFRFFLGPSPDGATESRVFDRVDDVGATIAGTLAVQLPAAELFYVSADMTDLARHAADTLTDYRLHPEDLPAQIGVMVYEHPPVQGTAAARHNAISIVTWGPGRGGLWVHTWATTSPSQQGIVRIGRTLAQLPRDEVLERARTAAARNLPEPTPENKPSDSDETADRVADHVLATFLPNLERAPVPPSFVPPHGYEWCALTPMEFTEMEGWPDGVSHPSRTTVGRATTTSPTWRCCWPTEAGGCPSGAGRGWTSAGRGPLPPQSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T830</accession>
    <name>A0A7W7T830_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein assembly factor BamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="440" mass="46233" checksum="51281810BB69C394" modified="2021-06-02" version="1">MGQPEQAESNDVVRVVSEEDVLEPDALGSDDEHHPEATPRTWRRGGDFAAVALIVVAVVVASLVLYSTSDAVDTTSQVGPSQATPLIPVTSLPPTLAEAWRASSGATPLPVAADGVVVTGDGGEVVGHDALTGEVRWRYARDRQLCTVSLTWGKVIAAHTKGTNCSEITTLELASGQRGPQRNGDAETGTRLLAEGSHVVTTGETYMEVYRREDLVRALEYGKLRAIVNPGKQPRVGCTYGSFAVVGGKVALIERCPHQDPADRLTVLKPNPEKSDEPQVLSSTVVGGTGARVIAVSPTRVAVALPGRLEIYDAETGGLLSEVPVEVTADELAGDPPGRVASTYTSTANVYWFTGSKTIALAGGDLTPLWTKEGTIGPGTTLAGRVLLPVRDGLLVVGQTTGAEEARYRLDRGGFTGTVEMATEGPVVLEQRGDTLVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E0</accession>
    <name>A0A7W7T8E0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ORF">F4559_005812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="274"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="359" mass="38631" checksum="F8BEE90F70F2A6C7" modified="2021-06-02" version="1">MSLTLGIVGLPNVGKSTLFNALTRNDVLAANYPFATIEPNVGVVPLPDARLAKLAEIFGSEREVPAVVSFVDIAGIVKGASEGAGLGNKFLANIREANAICQVIRVFADDDVIHVDGRVDPASDIETINTELILADLQTLEKAIPRLEKEARTVKDRRPALDAANKAKEILDGGRTLFSAQSEVDGDLLRELSLLTTKPFLYVFNADESVLTDDAKLKELRELVAPADAVFLDAKVEAELLELDEESARELLESIGQHEPGLHALARAGFHTLGLQTYLTAGPKESRAWTIPQGATAPQAAGVIHTDFERGFIKAEVVSFADLVEAKSMTAAKAAGKVRMEGKDYVMADGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8R2</accession>
    <name>A0A7W7T8R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40643" checksum="A502E04961710B03" modified="2021-06-02" version="1">MPIRTLTDDDAEPVDRLRKVAFGRATGRNPLQPGVRGLLTEIDGHAVGVLTIKDFHQFHGGTPVPMGGVGLVAVDPHARGTGVASAMLDHALRDMRDHGQVLSALFATVPGLYRSRGWERAGVLEWIELGLDRLPRSGPRVRSRALSEADLPALHACYVDLASTVNGLLDRRPPTFDPRHLLDADVVSVVPGHDGEVRGYLVAERDRTELRVHDLVGRDATTLQGLIAELGSWSGVLDKISVRVTDPAVTGLLTGQGIKYTSTVSPWLLRVVDLPAAVALRGWPVARHLANAAVDLDVVDEHAPWHAGRHRLVVEDGQVRVEPGGTGEVRVHARALGAWYSGMQDTNALRRAGLLDGPAGLLDLLVGVPGVPRLADFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z6</accession>
    <name>A0A7W7T8Z6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (TIGR03083 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="143"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25830" checksum="57874F9E384BF748" modified="2021-06-02" version="1">MGPNHVEAVERYGAAFTEAATGNPGVPVPACPGWTVEDLAAHLAAVQGRWAVVLDARGEPPDPEDLRRAAETGPDRLAGWREAHARYLAAQRDCPAYVKVPVWWTEEGRDTAAAVAERQAHEVVVHCWDAWQAVGAARSVPADLAADGVTEFLRRFLTGPDWPHGPLTVRLRATDTDDEWLVATDGTARPRLVTGNAPGLATLTGTAEELYLVLWRRLPLDRVDPTGPAAGFVAWPDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T933</accession>
    <name>A0A7W7T933_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="461"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="747" mass="78624" checksum="3A193C076D92F08A" modified="2021-06-02" version="1">MSGSTLAEWLRALDDRALVALLRARPDLATPPPADTTVLATRIGSRASVSRACEDLDTLTLTVLEALLVLDADLAPVGRDALAALFPVDITGALETLRGRVLLWGDDHLSTPPATRDAVNPFPCGLGRSVPRLAGVDLADLAGLGDDELRVLETLAAGPPVGQTRDAAHVVALDDATSPIQKLLARGLLVRRDAMTVELPREVGLAVRGDRPLGAVPTAEPPLPTRALDPVAVDSTGGGAALELCRHVDALLTAWSEEPPTVLRSGGVGVRDLRKLAKDLKADETRAALLVELVVNAGLVADSEGAEPEWVPTTQADAWSTASPEQRWATLALAWVDLPRLPGLIGRRDERDRLLNPLAPELNRPGAPRDRRRVLDALALPAPGTAVPDVDAFAALLAWRAPRRGGRLRDELVRWTLEEGTAVGVIALDALTSQGRTLLVEGTAPAAKRLADVLPAPVDHVLVQADLTVVAPGRLDPDLADEIALVADVESAGGATVYRVTEDSVRRAFDAGRTAADLHELFTSRSRTPVPQSLTYLVDDAARKHGRLRGGAAGSFLRCDDPVLVAEVLAHHAADALGLRRIAPSVLVSPLPLGDVLDGLRAAGFAPAAEGPDGRVLDLRTPGRRIASRGRRRPVPPATPSDEQLGELVRLLRAGDRAATTSGGARIAVPGHLGAGPSATLDLLQRAARDGLDVLVDFVDGHGTAARRVITPRYVGGGVLEGVDVSYGEVRRFPLHRITSAALVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T942</accession>
    <name>A0A7W7T942_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinogalactan oligomer/maltooligosaccharide transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030779203" evidence="1">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="42636" checksum="71A439BC94A76D3E" modified="2021-06-02" version="1">MRRSIGLLMVLLALGGCGGPADDPGEIVYWDTSGPHESPVFARIAQECATAGGYRVKVETVAFDAASNNFKTAAQGGRGPDVLRAEVAWVAQLAELGYLVELGGTDTADFLDTPVGSTRYGGRTYGVPQVTDSLALFYNRKLLADAGVTPPRTWDELKAVAGKLGGTKAFFLNNDAYYALPFIYGAGGDLVDAPRKKIVVNSPENVRALESAKGLLDGRAATTALDPGNSYAGMQAAFSAGEVAMVVNGPWSVADYLRGPAFADAANLGIAPVPGEREGRGSAPVGGHDYVVRQGGKSVDTARRFVTCMSSLDNQVRVSRELGLLPTRKSAYEHPDVKSNPVVAAFRPVVDAAHPRPWIPEGGQLFDPLKTAYADFLAGRKGAKAALDEVAGAYRDQVVPSYSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T978</accession>
    <name>A0A7W7T978_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="74"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="293"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="771" mass="82491" checksum="48369424F0DE70D3" modified="2021-06-02" version="1">MVCEAAGVGNEGRRLLRRVLAGVPVGESPLTHTADLPRRDARTAHWPTWAPADLVKELTSRGVERPWRHQVEAAEFARSGRHVVIATGTASGKSLAYQLPVLGALVDDPKSTALYLSPTKALGADQRRSVESLSLPDVRAATYDGDTPIAERDWVRAHANWVFTNPDMLHRGMLPHHTRWIRFFRRLRYVVVDECHAYRGVFGSHVALLLRRLRRVARRYGADPVFVLASATVADPGTSARRLVGVPCEAVTEDGSPRAARTVALWEPPLLEDLEGENGVPVRRSAGAETARILADLVVEGARSLAFVRSRVGAELAALGARRVLADVDPGLAERVAAYRGGYLPEERRALERGLSSGALLGVATTNALELGVDIAGLDAVVVAGFPGTLASFWQQAGRAGRGGEDEALVVFVARDDPLDTYLVHNPAAMLEKPVEATVLDPANPYVLEPHLACAAAELPLGEEDLADFGPAARGVLDDLVARKVLRRRPQGWYWTARERPHGEVDIRGTGGEPVIVVEGDSGRMLGTVDRGSAFRTVHEGAVYLHQGESYVVDRLDVADGIAFVHAARPDWTTTARDVKDITVVRTLEQRVHGGVTVSSGEVEVTSQVVGYLRKLPSGQVVDSVALDLPADTLVTRAVWYTITPDLLASLGPIRIPGALHAAEHAAIGLLPLFATCDRWDIGGVSTALHPDTGEPTVFVHDGHPGGAGFADRGYDALVPWLRATREAIASCACPAGCPSCVQSPKCGNGNDPLDKAGALTVLDAVLAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J5</accession>
    <name>A0A7W7T9J5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="37" mass="4131" checksum="9A56D07FD77507D7" modified="2021-06-02" version="1">MAGQYLAAGLTALVFLGRLAAHLYDWWLYSKCTGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N2</accession>
    <name>A0A7W7T9N2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3 4">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3 4">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase M15D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 4 5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR026671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22945" checksum="B9AD739790A22E88" modified="2021-06-02" version="1">MNEDFVFVDQWVPGIRWDAKYATWDNFTGKPVDGYLANRIVGTRALCAALGRAQEKAASLGFGLLLWDGYRPQRAVDRFLRWSEEPEDGRTKPRHYPNIDRPEMFEKGYVAAKSGHSRGSTVDLTLYHLDTGELAAMGGGHDLMDVLSHHGASGITAVEADNRRHLCSIMEDCGFGRYEFEWWHYSLKGEPHPDTYFDFPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N5</accession>
    <name>A0A7W7T9N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19438" checksum="C00D32B2F0D988C5" modified="2021-06-02" version="1">MNRSEVATLLGAAAAVDPKVPQPDPDVLDMWAAILDDVPADIAAEAVREHYRRRVETVMPADVVEHWRIVRRDTAERRHRGELTAHARRLDDRGLRAIRDGVTRVTAALAVTRGVDPEHAEAEADVRRAWLAVTCPYCRAQPGTRCAGPGGRPLTKTTAHPARLDAAFAAMTNQGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA96</accession>
    <name>A0A7W7TA96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="19134" checksum="C5E6F897B1A471CE" modified="2021-06-02" version="1">MSTDVVDLILADHRRFEELFRGLRDRSADRTTLLGELSALLVAHAEAEESEVYPALKRYKKVDDDEVDHGAEEHAEGHQALLALLEVGDTASEEWEDKLEELVEALNHHVDEEERTILNDARSEVADDRRAELGRRFVEVRQERLDDDCGDIAYVRRLAKETADRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB9</accession>
    <name>A0A7W7TAB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35965" checksum="B56D97BA860886A0" modified="2021-06-02" version="1">MEPVLARSVRLEPDGVHILDRRDFPFTREWVRCGTVAEVAKAIEDMVTQSSGPYFATLWGMVLAAREAVGTPDPHGYLRAAGELLIDTRRTNNALRKAVAIVLEHVAASDDPVAGALAGAHAGDERYRARSRALGVHTAERLPDDAAVLTHCWADLYLTETVAAAHAQGKRLRFFCTETRPYLQGARLTAETLAEMGVDTTLITDGMGASVLAAGEVDVLLTAADRVTMDGHVVNKVGTLGLAVAASAFDVPFLAMVQAPDRLAPTAADVPIEYRPGEEVLHTLGRRTATDRVRGHYPAFDVTPPRFVTDVVTDRGAFAPDRLADYYQEGTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB87</accession>
    <name>A0A7W7TB87_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="2">
        <location>
            <begin position="179"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="28393" checksum="0BA0AA3D7D9EBBBF" modified="2021-06-02" version="1">MIAVVVGGGTMGAGIAHLLLAGGHEVVLAESGADRVTAARDAVARSLAKAAERGKIDRSPESLLAALTVVDRLAAVPAELVIEAVPEDAALKHAVLAEAANACPDAILASNTSSLSITRLAAGLPAERVLGLHFFNPVPVQPLVELVRHPGVAPETVATARTWVEGLGKTVIEVNDAPGFATSRLGVAVGLEAIRLLAEGVASAEDIDTGMRLGYGWPMGPLRLTDLVGLDVRLAIAEHLAAELGDRFTPPDLLREKVARGELGRKTGQGFFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT64</accession>
    <name>A0A7W7WT64_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">F4559_000244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24299" checksum="92D5C51888CEF06B" modified="2021-06-02" version="1">MTSVEIRTPDGKSDGSVELPSAIFDAKANIALLHQVVVAQQAAARQGTHKVKTRGEVSGGGKKPYRQKGTGRARQGSTRAPQFAGGGVVHGPVPRDYSQRTPKKMKAAALRGALSDRARAGQVHVVSEFLAGDATPSTKTARKILDSVTEARRVLVVLLESEEASWVSLRNLPHVHLITPGQLNTYDVLVNDDVVFTKDALDVFLASKAQQGKGSAEAVAGSSEVEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT99</accession>
    <name>A0A7W7WT99_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8115" checksum="6E87726CCFE6D2DA" modified="2021-06-02" version="1">MTTAVELSGRAKAMLRAVAAGRGELSGGREPDLYVDGLPCCDQTVTHELVNAGLLRTHARFGVRVGAELTDLGHAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV5</accession>
    <name>A0A7W7WTV5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="444" mass="47058" checksum="F89E48CB1881B076" modified="2021-06-02" version="1">MTRIKRSMGQAGEPEPGLTAEVVRRWESGDRKPEPRYQKHLVQVFRLPASDLGLLSSEELALRPRRPAEPPAVTAQDVDAIVRKVTLVLLGNGNEFNRKMFLTGQLGASLTPLLTQGLALPDSIEALTRTPGSTLDPRAVDAFAAIATSHRSLYWTRPAADLLPAVVSHAQFGENLLKTTTSVGLAAAVAESALLAARLAFFDLDREDLAGSFFRLAQDAADHSRDHGLAAAVLAHRAFVPGFAGRGPEARALLAAAHAHVRYDGGPLLRSWLHCVDSEISARTGQAADSVARIRAAEDALTTIGTDALWLDFYDSARLDGFAGNSLLLAGRPHDATPRLRNALDRLSPTAGKQRAVVLFDLAAAQASTDAELAYTTAGQACDLLGQACDLLGQACDLLGQACDLLGQDGYAMAAKRAPEVGKALAGTPYAALLRERVRAATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ9</accession>
    <name>A0A7W7WTZ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035166">
        <property type="entry name" value="DUF5336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17270">
        <property type="entry name" value="DUF5336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="23274" checksum="4966E07436FB753D" modified="2021-06-02" version="1">MSVPYGAPQQQPGPAQPAVGVNLNLILPLAGAGLGVFAYLLSFADDVSSAGIEYLLAAAALSGLSVLPKAPKLLYAAAVFALVPFLGLIQNLIKSEADVQGMQIVILIIALLQTAAIAIALLLDAEVVKFTPKQANVYNQPGGWNPQSGAFPQQQVQHPQHPQQQYGPPSGQFNQPVQPQQPQQPGQPQPTSYLSQPGQFAQPPQAGPQHGQGTPPGGFTQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU26</accession>
    <name>A0A7W7WU26_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="44258" checksum="A0910B9C2E974869" modified="2021-06-02" version="1">MAQDIVPIELGLTQGDVVTLWAPRWREEGEEWEAFLGHEENLYVFPDAAHLAAFVRKTEEHDLTDHPAWHAIPGLSVGELSPDDNHQFDLVGVPELVAEEPDTWVIGELADVVSIVRSLADVCELEKVHEILDSAEGFALLPQGTLPFTGRDGAALWTEISEVVAEKWDDVLDALDEVVAQPDVDEAELERAQEELAAFEEANAAAAATSDDEDDEDEDGEPTGFWAEVGIDPIKIISGAGEYYTLRCYLDEEPVFLGRKGRIDAFTSPRALSRFIVEADDNDLSEVSTWGELVVKATGGDLDVEIDPDNVYVLTGLDEDIADGPDAVDPTQLDLVVELLEDAGDWAGDDTVKVALNQSESLGWLVSYVLKPDPTRLAPSAPFDAEVTAWRTLVASFEDRLKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU53</accession>
    <name>A0A7W7WU53_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="181"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="43864" checksum="528DE1A41318C958" modified="2021-06-02" version="1">MPRPPLRIGTYGEINTTRLTPGDVTPAKWRADCRYRDYAGKVGRLERRATTEAKAKAALKAALAEILNEDLPAGADTKFRAVAAVWLDRIRTEHVGTTYDRYKGRLEGHVLPAIGDLYLRECTPGRLGRVLSAMKANGLSAPTRRGVRTVLSGVLQEAVDRGLLGRNPVRDMGQIKDDGRKKAVAAYDDKQLVDFLARLDGDRYSARADLRDLIRLLFGTGARFGEALALQWGDVNLGSDAIRMRDSEEEVVVPAGGVWFHANLVSVTGKGVVRHEGKTATSRGVVVMPEFLVDLLRARKPDQVFPGTAIFPSALGGWRTPSNVQRAVRRMRIRIGYPRFTTHLGRKTVATALDRGGHSAREIAGILRHANPSMTQNIYMAKGEPNRRAAATIHRLHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY8</accession>
    <name>A0A7W7WUY8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylpyruvate isomerase</fullName>
            <ecNumber evidence="3">5.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050077">
        <property type="term" value="F:maleylpyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="37"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="27931" checksum="5973C3B0E606B039" modified="2021-06-02" version="1">MSSTDAAQVRSAGTTVPAPREQSAAAQDAVAGIAEVRRAGQVLYEVVERLDQSALRGPSLLPGWTRGHVVSHLARNADALVNLLTWAKTGVEHPMYPSAADREADIEEGSGRAPQLMRADLDAACRRFLVAAADLPATAWEAEVATRLGPLLAHRVPWLRVRELWVHLVDLDAGFGFEGVPDDLVEGYIDEVVTAFTGHAHAPSVTIEATFPDGRQRTWPLGSGSAGESRTVSGSAAAVLGWLTGRHSGAELNGTAPTLPKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV47</accession>
    <name>A0A7W7WV47_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ORF">F4559_001517</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22461" checksum="8B8D8DFC4C9E27F8" modified="2021-06-02" version="1">MARVVVLDYGSGNLRSAERALQRVGADVEVTADPDAVLDADGLVVPGVGAFAACMAGLEQVRGARLIGRRLAGGRPVLGICVGMQILFDEGVEHGVRTEGCAEWPGTVERLDAPIVPHMGWNTVRAPGDSVLFDGLDDDTRFYFVHSYAVRKWTLESSDTLRAPLVTWADHSGDPFVAAVENGALSATQFHPEKSGDAGAHLLRNWLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA2</accession>
    <name>A0A7W7WVA2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RES domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="60"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="24062" checksum="FBDAEC952D8F39AE" modified="2021-06-02" version="1">MSRLPLPPAPAVLQASLRRTEDVVAVHRATRMVRIFTAKGLHPQRWNSFRYTGPLPHARFDTQIGAPDGSFVHAPDQGVLYFGLTVRTSVAEVFQATSVVDRRTRSPFMVILRPRRTLRLLDLTGLWPTRVGASQEISSGPKHLTQAWARAIRAAYPELDGLWYRSSMDSGDPAICLWDPPGGTGLPAAPDVLLPLEHPGLDLPLARVCEDLNYTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF6</accession>
    <name>A0A7W7WVF6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19183" checksum="A202D61650160C3D" modified="2021-06-02" version="1">MERSSKHLVSRVLVAVAAAALLGGLGVVFMPTRDRVPAFDIGSGTAPECPVDALPRPEPSPDGIVRTTLCAFAPTADGTGRYSRALVLESDGEEIVEELTDLPDRPLPDQGCFAVLRPHYRLVVHYADGAERAVDVDLACATATSADRTRYGDVPAVLDAFAEEYRDQGGDLPPPPWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF9</accession>
    <name>A0A7W7WVF9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031378351" evidence="1">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="14639" checksum="5A67AFC503B2DFA1" modified="2021-06-02" version="1">MRRFILSLAVTLGLLTGGAGLATAAEAVTTSTPVVHVVSQPSTSGPVDTVPGATGTSVVGTSPGVDGTVRPAGVGRWIVEALIKLGRKIYDAAVAAVKAGWAAFKSWFDSLPWLIRQLMPVGAEELFRAIACHVLNQQWAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH3</accession>
    <name>A0A7W7WVH3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="7093" checksum="F42A9F1035F4FCE2" modified="2021-06-02" version="1">MSHPDRWKHARWKVSSRSGNGVQCVEQAAIADTIGVRDSKNRAAGLLEFDPAAWSRFLVDLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH4</accession>
    <name>A0A7W7WVH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4341" checksum="3D6D9DDD44D36482" modified="2021-06-02" version="1">MRVTTSGQETARQHDALDGIRAKVFEARPGGTLARGARRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI1</accession>
    <name>A0A7W7WVI1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030938540" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="92" mass="8963" checksum="0D565A7167B20CE9" modified="2021-06-02" version="1">MHRAVTTLIAATALAVSVVSAPAASAREAVASAPADCVAHLAANGFTDTPAATSVCRVATVDPSFCEEVLGGRGVARAVAVEACRLAATAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR7</accession>
    <name>A0A7W7WVR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="1">
        <location>
            <begin position="250"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="43709" checksum="E4DCC7C45C4B813D" modified="2021-06-02" version="1">MRIVSQVEFGTVLSRVPSCPRVVASGNFATPWVALGIVDEVLAEYRLFMLNAQPGVPDRDGVVLETPFVGPGMRGRRLLRYFPSRLSLVPQLLGGPLAPDVVLIHTSEPFDGTVSLGTEVNILPAAIDAVRARGGLVVAQLNPRMPYTYGDAVLPVDEIDYAIEVDEPLASPTPRPVTDVSGEIGERVAALVGDGATLQLGIGAVPDAVLAALTGRRGLAVWSEMFSDGVLGLGDALDPDMPVTASFVFGSAELYAWVDRNPRVRLLRTEKTNDPGIIARQRSLVSINSALQVDLYAQADASRVRGRIHSGFGGQTDFVVGALHSPGGHAIIALPSWHPKADVSTVVPSLAGPVTSFQHSYIVSEQGTARVWGHDADGQAQQILDHVAHPDARARLREEGRRLGFALLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS2</accession>
    <name>A0A7W7WVS2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24512" checksum="1767C7FC4990A6E0" modified="2021-06-02" version="1">MPRLLLVEDDAMLAEALSRALRGLGHEVSVAESGERALEFLTRGTADLVLLDVMLPGIDGFEVCRRVRARDAVPVILLTARGDAVDVVVGLECGADDYVVKPVEPRVLDARVKAILRRAAPAAPRADVRTIGDLELDTAAMTVTRAGVELRLTATEMRLLIEFADHPGQVLSRQTLLKRVWDYGFAGDSRLVDATVARLRAKIEPAPADPTLLLTVRGFGYRLVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY2</accession>
    <name>A0A7W7WVY2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lysine 5,6-aminomutase beta subunit</fullName>
            <ecNumber evidence="3">5.4.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047702">
        <property type="term" value="F:beta-lysine 5,6-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028991">
        <property type="entry name" value="KamE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036843">
        <property type="entry name" value="KamE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16554">
        <property type="entry name" value="OAM_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117778">
        <property type="entry name" value="SSF117778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="103"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26469" checksum="4952A1C96BA22D3E" modified="2021-06-02" version="1">MTRHVRPYGDTTGDGMVQTSFTLPVPPGPKADGAARLLAERMGIDPATVVHSHGIGDGFTFFVVYGPVRHVIDLADVRVVEREYPLLSPAEVNAAVKRVLRRKLVVVGGCIGTDAHTVGIDAILNIKGFAGEKGLEYYRELRVVNLGAQVSVPELVRRARAEKADAVLVSQVVTQRDAHLLNTRELAAAFREALGARRPLLVAGGPRFDPLMADELGVDRVFGRGTTPGEVASYLVHAVHARKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF2</accession>
    <name>A0A7W7WWF2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="646" mass="71470" checksum="150CAF294C528F4A" modified="2021-06-02" version="1">MLEVENHNVASDDARVEQQIGVQLTECVFHSANIYTVTEDDTAERRYEVALAYLAGGVPRRAEDLLRELAFGVDQTSGHVYHYVLSVFSDRGLGDLTKDLTAGLRDARKIAEGLPDDGWGRANRVVWSLFDHVRKDRSGDTFAAVEAFGRLPAPRQDEIATHLSRLVAGSVEQRLNAERKHQVGVERLSGDRIGRVWKYFEPDPAPPSRYEPRLELPRLTGRRSAVLGAVAAAVSAVGLFTGPFTASFWGGLAVMVAGCAVMGGFGVAHTAHLVQVALRREAAESAGGRGAATPVDRLIDHCFRETRPEFAHDWPNYAAGYAARLKTRFNAQLWDQDRVSLRRWKWLFDWHARRVADRWPHHDPIVRPEGTVPGGARLWQVVGVLVTLAGLGLLLVAAQRWWAVPLAVGGGFALPTVLEVLAARRAVLRPRREADALFDEENDEFLRWRAELADRPGDGEMARWLALDKAHLKSAVLRGGDIGERDLVSHVVLTQPAPGARRGSVTHGPPRYSAYLVTVILLTRRGVQASRVYLDFGSGEVKNEVRDVFGYDRIVSASLRMEDGRRVRRREFRLTLVNGAEIITVAERLDAGSDTAAADEAELERLAAETSGMDAALPVLLAVAREGTAWIGFELERQSLRSRDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV0</accession>
    <name>A0A7W7WWV0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ORF">F4559_003332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="540" mass="55614" checksum="9E1124494A5AF0AF" modified="2021-06-02" version="1">MSSTAAGLLQVGVLFLALAVAYRPFGDYMARVYDATTHSRVERAIYRVARVDPDVGQRWGTYAYGVLGFSFVGVVLLYVLQRVQSVLPLDFGRGNVAPGMAFNTAVSFVTNTNWQSYVPEAVLGHTVQLVGLTVQNFVSAAVGLAVAMALVRGFVRRRTDRLGNFWVDLVRGTIRVLLPVAGVAAIVLVASGVVMSFASGVDVDGTTVATAPVASQEAIKLLGTNGGGVLNANSAHPFENPDGWTNLVEVFLVMVIPVSLTRTFGTLVGDPRQGRVLLGVMGGLWSAMLAVIWTAEAHGLRPLEGKELRFGVPSSALFADATTGTSTGAVNSMHDSYTGLGGGATLLNMLFGEVTPGGVGTGLYGILVMAVIALFLAGLMVGRTPEYLGKKLGRREVTAAALAILAMPTVLLVGAGVAAVLPSTPGVLGNPGEHGLSEILYAYASASNNNGSAFAGITVTGDWFQASLGVCMALGRFVPIVAVLCLAGSLAAQRGTPVTAGTLPTTGPLFATVLAGAIVLVAALTFVPALALGPIAEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ5</accession>
    <name>A0A7W7WWZ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="275"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="307"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="528" mass="56294" checksum="236FC2ACA6BA4310" modified="2021-06-02" version="1">MSTTDPVLAVRDLTVSFGPVQAVRGIDLTIAPGEILALVGESGSGKSVTARAVLGLLPHTATVGGSARLGDRELIGADEDELRSVRGKSIAMVFQEPATALNPVHTVGRQLAEVLRVHRPLTRKQARGEAVRLLDLVGIPEPATRVRHYPHQLSGGQKQRVVIALALANDPALIIADEPTTALDVTVQAEILDLLRDLRDRLGTAILLITHNMGVVADLADRVAVMHRGEVVEQAPVEDLFARPARAYTRELLESVPRLGHRAPAAPHEAETDALAFDGVTVRYGAFTAVSDVTLTVGRGEVVGLVGESGSGKSTLGRVAAGILRPANGTVSVLGGDPVDPAVRRRLGFVFQDPGGSLNPRLSIHDCVAEPLRVHGVDRSAHRARVVELLDAVRLPSSYVDRRPRELSGGQRQRVGIARALALRPDLLVADEPTSALDVSVQASVLALLTELQREHGFACLFISHDLAVVDSLAHRVAVLHRGAVVEQGPHHRVLRDPSADYTRRLVDAVPVPDPVAQRARRTGLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX87</accession>
    <name>A0A7W7WX87_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="872"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="931" mass="100764" checksum="94E01396F8FA851F" modified="2021-06-02" version="1">MTPPRTSSPVLVGRGAELGALIDVVSAQPSVALVAGEAGVGKSRLVRELLGRPEVAPLHVLTGYCQPLREPFPYGAVLDALRGVGVLLRRKELSPVTGALRPLLPEIAAHLPGLPQRPEDPRHERHQLFRATRELLSVLGPVLLVVEDLHWADDGCRNLLRFLMADPPPNATVLVTYRREDAPGGMPLGSAYRPPAGVPGAVLELAPLDVDQVRELAAAILDVDAVPARFAARLHERTAGIPFVVEEMVRAVRGPDWGLLDEVEVPALLRDAMAERLARLPRTGRRLAQAAAVLGVPADEGLLARVGAVEPDRARAALTHALQSGVLYETTDVRYGFRHALAQQAVYDTLTGPERQRLHVRAVAALSHVTPRPYMQLAEQSRRAGLHADWLLHGEAAADRAQEVGEPATATNLYRRLLDEAALEPSDVDRLAVKLGQVARGGIDQHDPRATLERLLTDPRLSTAARGEVRLNFGYLLIRQFAGVRQARAQIEVAIEELTSRPDLAMRGVTVMAQPFVGDTPVREHLRWMRLVDDFIRECPQDDVRFSLLANELGSRMSIGEHAVLSELDELPETSADVATRRHLARANCNLADACALVGHFDLARRLLDRGLRLTVGAGVPFTASTGQSTSIHLDWYRGEWGTLAERGARLLEEYRELLPVAAEISLVLGSLAVARGDWPDAERYLADSGVRDVENSITPVALGGFAALARLCLARGDVPGACAEADRGVDLARRKGVWVWTGELAPAAVDAYSAGGRVEDAVKLVEEMSAGVADRNAPLADLGLLTCRAYLADEPVPLLESARRAADALVLPYHSTLLVERIALHALANGDASALTEVADRFDALGASRDAARCRHVVRGTGASTPSRRGRRGYGNALSPREREVARLLAQGRTNREIADVLFLSPRTVEQHVARVLRKLGVASRADLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB3</accession>
    <name>A0A7W7WXB3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan/xylan/chitin deacetylase (PgdA/CDA1 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031497114" evidence="1">
        <location>
            <begin position="29"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="46"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25873" checksum="28280A6648FFF947" modified="2021-06-02" version="1">MRKWVVVAVVAVLVVVGTAVGGWRLASARTFQLFGDLTSAVETDQRVVALTFDDGPDPAGTADLLRTLADKDVPATFYLTGRELVAHPDLGRAIAAAGHEIGNHSFSHRRMVLVTSDFVADEVERTDAAIRATGYTGPITFRPPYGKKLVALPHYLARHDRRTVMWDLEPDSSPEADKSAEAIARSTVEQARPGSIILLHGMYANRKSSRDAVGPIVDGLRAKGFRFVTVSGLLALGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB4</accession>
    <name>A0A7W7WXB4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031028608" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19077" checksum="4271030B1DEB2971" modified="2021-06-02" version="1">MGIKAKVLATFFAAATLSAVTTGVSAAAAVDEGPTAGTPEVGALAWGSIKTRLNGRCLDADANTLPNNGTKVQLWDCNGTSQQSWELRSVGNGYYTIHIRWSGKCLDADANNGGNGTKVQIWDCNGSAQQRWYKYGESGTSRFVNDFSWRCLDADANAGGNGTKVQLWDCNGAPQQGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ1</accession>
    <name>A0A7W7WXJ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="503" mass="51792" checksum="AB5B6B33670B1F27" modified="2021-06-02" version="1">MPRVPTLIAAACAAVAPFLPGGAARPDALDLPVVGLAVIVVLAAGVSLSRTPWARIPCALVGTAVAAVCLRLDVADGLPAPRLSVLAAAGLGVAIAIAARDRVRLVAAVAIVGLAIAVPAVTRVAVVHSETAGEGGAVAPVVERPVTRRWAWESSDPISYVVAAGRGVAVATVEGEVVGLDGVDGRVRWRYARSGGHVLDLTASADERAVVVAFGSPADTTSNLVVVLDAQSGRPRFERVVSGVLVSAGEIVPGKATMALREGTDDHTIVAYDLETGGERWRWHAPTGCTSPYALPARGRDIVVAPLECPERVGIMALDEVDGRQRWMHVVTTRPPDGQAQTLLPRGARDGALLSLSITTGRAVPGAALSGLFDSATGVRYPDHPEQGWWVRLDLGPTPVVERSDHESVLDPRKGTLTPLTHAACEKDDKAATTASTYLYVCDGGDRVSLSVQDFTGTPAAVSTIDLPASPGSRIALVPASGAVVLARVSGDGPATVVGMASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY12</accession>
    <name>A0A7W7WY12_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">F4559_005284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="6"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="421" mass="44357" checksum="A822A3D9F7381310" modified="2021-06-02" version="1">MTDDLRDEVHAAARRARVAANDLVLATRERKDAALLEMAAALRTRAPEVLDANAKDIEAGRAAGLAEGLIDRLTLTEARIGGVARGLETVAGLPDPIGEVLRGSTLPNGLELRQVRVPMGVVGMVYEARPNVTVDAAGLALKSGNAALLRGSSSAEHSNTALVAILRDALEAVGLPADAVQLLPCHDRASVTHLITARGLVDLVIPRGGAGLIDAVVRQATVPTIETGVGNVHVYVDASADLDMAQRIVLNSKTRRTSVCNAAESLLVHEAVADEFLPRIITALRQADVTIHGDERFAQDPRVVPATDEDWDTEYLSLDLAARVVESLDQAVEHIAEHGSGHTEAIVTDDVRAARTFTARVDAAAVMVNASTAFTDGAEFGMGAEIGISTQKLHARGPMGLAELTSSKWVAWGEGHVRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY94</accession>
    <name>A0A7W7WY94_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23119" checksum="8726ACD9B92C5E8C" modified="2021-06-02" version="1">MTETAQGAVGHGGAGRGVRLPRTARRAQLLAAAQDVFVNNGYHAAAMDEIAERAGVSKPVLYQHFPGKLDLYLALLESHVDELVDRVRGALASTTDNKLRVQAAVAAFYDFVDGEGQAFRMVFESDLRGEPAVAKAVERATTDSVDAITETITSDAGLDEDRARLLAVGLVGLSQVTARSWLADDRRLSKEDAVALISNLAWRGIGGGFPLHPNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYC7</accession>
    <name>A0A7W7WYC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23435" checksum="718739638E45ADDC" modified="2021-06-02" version="1">MARTGTDSRRERWKGHRETRRAEFVEAAIRAVARLGPDVGMDDIAAEAGVSKPVLYRHFTDKTDLYLAVGRRGTAMLLDRLAPALSQDGPIRARLRTIVDGYLAVVEEHPNLYRFVVRGPVERGAEEALVSAALARILGDHLRAVGVAADGTEPVAHALVGMLRNAADWWLDRRSMSRTSLAEHLTAIIWHAVDGLLRAAGLDADPDARVPAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG2</accession>
    <name>A0A7W7WYG2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="13"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="535" mass="59636" checksum="171D9992DCEDE12F" modified="2021-06-02" version="1">MPPRTKAKQDKSLEEVLWDSATALRSSMDAAEYKHPVLGLIFLKYVSDTFTARQEELTGLVNDPDSDYFMPNETAKQSVLEDRDEYTAEGVFWVPDGHRWQDLRKAGKQTNIGARIDGAMAAIERENPTLRGVLPKNYTRQELTPEMLGGLIDVFSRADLAAEEHKGLDVLGRVYEYFLGRFAGGEGKRGGQYYTPRSVVQLLVEMLQPYHGRVFDPACGSGGMFVQADKFVRAHGGVRNDISVFGQESVPTTWRLAKMNLALRGIDANLGAEWGDSFHNDQHPDLRADFVIANPPFNQDGWRGTRLENDVRWRYGTPPDGNANYGWIQHMLHHLAPTGTMATVLANGSLSSQQSGEGEIRKKLVEADLVECIVALPSQLFFGTQIPVCLWFLTKNKAGIPNGAATRSRKGETLFIDARKIGFMEARTLRAFNTDEILKIADSYHAWRGTDASSDQPYEDIPGFCRVVRTAEIAEHSYILTPGRYVGSEEVEGDGEPLDEKIARFNDEIREGFKKREELQAAVLTALGSLVVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYP9</accession>
    <name>A0A7W7WYP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low temperature requirement protein LtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="PTHR36840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="42245" checksum="25B2E6736F4C5BB9" modified="2021-06-02" version="1">MITPRVVREGARVTPLELFFDLVFVYAITQVTQLMAADASVHGVLRGLLLLAILWWCWCCYSWLGNRVRADDDGVRVVLFAAMAVMLVAAVAIPEAFDDLPGGLSGPLVFAACYVVVRVLHLVAYWRFSVGDVPLRRQLAVTLAPMLSGSVLLVVAAFTSGATQTALWVAALVVDYGGVLVTGVSGWRVHSAVHFAERYGLIVLIALGESIVAVGVGVADLPVSWPIMFGIGCGLVVAAALWWAYFDVDAPLAERVLHQAAGAKRAALARDAFTYLHLPMIAGIVLSALGLKKTMNYLAGADGHTASEHLHGVGPFALFGGVLLFVLGHLGFRLRNLGTVNAVRVVVAVVLVAETPVAPLLPAWGALLLLTVTCVGWIAVEAVRHGQVRGEVRAEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR3</accession>
    <name>A0A7W7WYR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Broad specificity phosphatase PhoE/ribonuclease HI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014636">
        <property type="entry name" value="RNaseH/PGlycerate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036922">
        <property type="entry name" value="RNaseH_PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="38190" checksum="B6393F66B10D397E" modified="2021-06-02" version="1">MKVVVEADGGSRGNPGPAGYGALVRDAASGAVLAERYAGIGVATNNVAEYQGLIAGLRAAADLGADDVLVRMDSKLVVEQMSGRWQVKHPAMKPLAAQAREVARAFATVAYEWIPRARNGDADELANRAMDEQAGIEPSGAATGTAAHVTAPPAVWSGAVGEPTRLYLVRHGQTALSVERRYSGRGNPALTDVGRRQAAAVGRRVTSAVLPAVVLSSPLDRALTTARAISADVVVDEDLVEVDFGTWEGLTFAEAADRDPDLHRRWLGDSSVPAPGGESFDEVLVRVGRLLDRVLDRWAGRDVVLVSHVSPIKQLLRLGLDVGPTLLYRLHLDLASVSVVEFYPDGFASVRSVNDTSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR9</accession>
    <name>A0A7W7WYR9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15945" checksum="28DAB0B6FF0E8B98" modified="2021-06-02" version="1">MSGTSGRKTLAQRIDYLFRTVRPPHRREYTYEEVAQAVARDQRETISASYLWYLRTGQRDNPTLKHLTVLARFFGVPTAYFVDEPTGERVVAELALLAALQDAGVRDVALRAAGLSPASLETIGDMIARVRELEGLPPRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW2</accession>
    <name>A0A7W7WYW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="7760" checksum="B442999B3AB5725D" modified="2021-06-02" version="1">MNSVLAIPTSVCAAIGDTTPIRHEVVGEEVRIAFGRNEIDLVLSPRAVHELATRCTIALDILAAPEPDENVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW3</accession>
    <name>A0A7W7WYW3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enamine deaminase RidA (YjgF/YER057c/UK114 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="15521" checksum="E18B30BCCF348BD0" modified="2021-06-02" version="1">MTWSDRLRELDVELPSAPAPLAAYVPAAQSGSLVFTAGQLPFVSGALPATGKVGADVSPEEAKGYARTSAINALAAIHELVGIDRVVRVVKVVGYVAVAEGFTAVPAVLNGASEFLGEVFGDAGRHARSAVGVSELPLGSPVEVELVVEIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY3</accession>
    <name>A0A7W7WYY3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">whiB</name>
        <name evidence="14" type="ORF">F4559_005582</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="13766" checksum="67CDBFE6C021C414" modified="2021-06-02" version="1">MLTATVPIAGALSTTEPDLTGAGVASLIDTAPDAGLELPCRTNNPDLWFADAPAELEEAKKFCVSCPVIAECLAGAIARHEPWGVWGGEIFERGAVIARKRPRGRPRKDAAPVVPAAPAATVVRGAKNQEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY7</accession>
    <name>A0A7W7WYY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31865" checksum="E0CC10B341BAF5A9" modified="2021-06-02" version="1">MANRREWDQVPEPVRAAVESRIGAVLTAESPSAGRSSELSVTLTTDSGRVFCKGVTDGSSLAWMHRNERAVSPFLPERLAARLLWDIEVDGWLVLGFEHVAGRHADLSPDSPDLPLIADAVEEIGRTAPPPESVARRPMAAQWAQAMKTETALPPPADADPWSIANAGRLVSWAAHAPDHMTGDGLVHSDLHPLNFLVSDRTRVIDWAWWRTGAAWIDPAFLVIRLIAAGHEPEAAEKWAGRFDGFAAAPPDALTAFAASVLRLWERRFPTTDTTDAARRWARHRVPAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZT9</accession>
    <name>A0A7W7WZT9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030551352" evidence="1">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20173" checksum="E51E161033C878DB" modified="2021-06-02" version="1">MAALVAVLIVVAAAGWALASPAIHQTARTVPPTGERGRQAANPLAIANLGPGGDRYAWVTAFPQVEGAGFLGTEEVGAYNRGGADAARLAVWNGFPAGRVIIVVVRVADASTATRVADRLDELQAGFGLQRLSPVRGLDRVSTVTFEGRFVTRALYTHHDLVVRIELRGDPDELSAFDGIVSDQLHALPAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZV9</accession>
    <name>A0A7W7WZV9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="465" mass="48770" checksum="4441FACC7845E51C" modified="2021-06-02" version="1">MTLVLRYAARSDRGLVRSNNQDSVYAGPRLLALADGMGGHAAGEVASKVVIAALAPLDDDEPGDDLLGQLRDAVISGNSAISELVQSDPDLDGMGTTLTAVLFAGSRLGMVHIGDSRAYMLRNGVFTQITHDDTFVQSLIDEGRITEEEAATHPQRSLLLRALTGHEVEPRLMVREARPGDRYLLCSDGLSGVVSMETLDEAMRIPDPQACADRMIELALKGGGPDNVTVVIADVVDIDFGEDAPIVGGAAGDGSADPPPPDSPASRASSITGPRPVPPRVEAPPPPPPRKRGAKVKALALVVFLLLVLAAAGLGTRWYVMRQYYVGTTEDGQVSIFRGVTGSVFGINLHSFVEGSCPPGAQACEPITLDDLKVSTRDVVRNGITEVDGLEGAREAIRRLRTEQTLPFCPKNPPPATVPATTTPAAPTTTADPSATGQATPPTTTTGMPLTTSVPKPGTDCRKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X012</accession>
    <name>A0A7W7X012_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="47680" checksum="E6A78A802FB2B14D" modified="2021-06-02" version="1">MPQYQQFPLPDTAEGLTEAEILTWHVKPGDTVRVNDVFVEIETAKAAVELPCPWDGVVTELLVQVGQTVEVGTPIITIDVDPAGAAAVAAPAAPAPAVNGAAPEAAAPVEERVANLVGYGPRTGAAKRRARKDAPAAASVAAPVVPAVVEPPRVEAPVVTQHVVVEPVSGGYVPLAKPPVRKLAKDLGVDLYGITGSGPGGVITREDVEQALTAPAPASVEVVAGARERRVPIKGVRKATAQAMVDSAFTAPHVTEFLTVDVTPMMELRARLKNSPEFRDVKLTPLAFAAKAVVLAARRTPDVNAAWDAAAQEIVYKDYVHLGIAAATPRGLVVPKVRDADRLSLRELAIALDELATVARNGKTTPADMVGGTITITNVGVFGVDTGTPIINPGEVAILAFGAIRDMPWVVDGQVVPRKVCQLALSFDHRVVDGQQGSRFLADVGALLADPGVALTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXD0</accession>
    <name>A0A7W7SXD0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA editing enzyme YbaK/EbsC (Cys-tRNA(Pro) deacylase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="44"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="18416" checksum="493B55E0EB0A8978" modified="2021-06-02" version="1">MWTIAGTLNPVPAPDRPDLVAPPVAALLGAFPDAARLGVAEIDPTLADTAEFCAHYGSPLEASANCVIVAGRRGDVTRYAACVVLATTRADVNGVVRRLLDARKASFAPMDDAVSLTGMEYGGITPVGLPAEWPILLSPEVAAAPELVIGSGIRGSKLLVPGEVLAKLPGAQVVEDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXF6</accession>
    <name>A0A7W7SXF6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1713 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015105422.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="33" mass="4160" checksum="8156A99AF16291F5" modified="2021-06-02" version="1">MGSVIKKRRKRMSKKKHRKLLRKTRVQRRKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXM5</accession>
    <name>A0A7W7SXM5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="12" type="ORF">F4559_000222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030646634" description="50S ribosomal protein L11" evidence="9">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11_N" evidence="11">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="10">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4962863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15285" checksum="CC02AC7D7ABAEC38" modified="2021-06-02" version="1">MPPKKKKLAAIIKLQIKAGAANPAPPVGPALGQHGVNIMEFCKQYNAATESQRGTVVPVEISVYEDRSFDFKLKTPPAAKLILKAAGVEKGSGEPHRVKVAKITQDQVREIATAKMVDLNANDVDQAAKIIAGTARSMGITIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXT6</accession>
    <name>A0A7W7SXT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="26155" checksum="8E0F22B9FBC390E7" modified="2021-06-02" version="1">MSNSRLLDTRGQDRGVAPEFLVDPKLLDVVSPPGDRGGMVLGSGAKGEPLTVSVLRSTPTRMVVVGGLYLARQITLRAMATGAWVTIATGRAQVWQPVVRAAGTTPDGRPSPAVQLRLLNPVELPRPSEDSPLLVVHDGGHVPQELFPPRAPWQTTMYVLPYLHPQASSTLTSADLVLIQRLPIGQAQLAAQIWRLPPPLVHQLTTLKDDQVIAFGVNLWQPLRLVTTPGEKQILGAVRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXV9</accession>
    <name>A0A7W7SXV9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="8" type="ORF">F4559_000308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="30"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="350" mass="35960" checksum="986A7600794AB47E" modified="2021-06-02" version="1">MTDRLILGFESSCDETGVGIVRLGPDGALELLADEVASSVEEHARFGGVVPEVASRAHLEAMVPTMRRALETSGVELSDVDAIAVTAGPGLAGALLVGVSAAKAYAAALNKPLYGVNHLAGHVAADTLQHGPLPARCLALLVSGGHSQLLLIEGLAHRITEIGSTVDDAAGEAYDKVARLLDLPYPGGPPIDKLAKQGNACAIAFPRGLTGPRDPRYDFSFSGLKTSVARWVERAERAGEEIPLADVAASFQEAVADVLTAKAIRACKDLEVDTLVISGGVAANSRLSGLAAERCAEAGIELRVPRPRLCTDNGAMIAALGAHLVAAGAGPSRLDLSTTPGLPVSTVQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY59</accession>
    <name>A0A7W7SY59_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14185" checksum="A960B2318416D341" modified="2021-06-02" version="1">MGQEIRIGDAEREKALELLGVHLGDGRLTITEYGDRSAQVTTARTRGELLALFADLPAPKPQFEPRPAVPPMPPAFVPPSFPARPRFDRSYVPAVVLGCVALFFAFRSPAVFLLIPVVMLILHARGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY63</accession>
    <name>A0A7W7SY63_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="536" mass="59411" checksum="0C4022CE472A59EC" modified="2021-06-02" version="1">MVERQWEGLPVWIFGQVWLWSLLSFVAGVLLTWLVLVRPLKQEVQALRSRTPQAPPPAARDDFDDWPVPVGVEQPRHVAEDERRFEDHPELADDRAEPAYPQSYPQSEPSYPQSEPDEIVRTPFDPAVEAPLDPVDPDSRRAYEDALDQGLVPLSEPIRVFPETPPVRDHEPVDELRRLEEGTERTALIEPWDGMYADDAPEPVAGPHRDEEDEPERPSAAEATTLIPATALAQAIAEVDSRPAEDDGQAWPEHDMTGRFEPVAAEETTTFEVVEEPEPVVAEETPAEETTFLEPVVDEEEQPEVSQPVEPESYRPFSEPGSEEPTAFDPFTEPDPDDYEPLPPAPEPPKFDPFAAPKETFEPFAPTAAEPDEPARPRSLFEPLTDPEDGKELETPRPASSKPVIDQPFVPTLAPELLASMGTPEQPLPTRPATGNNALPQRPRPVGFSPSTGAEPATPSARYQQPEGFNPRSPFGPGSVLPRSDGKAPAPEFEVKATLTGRRYFTAESANFRDTRADVWFRTVADAVKAGFRQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG0</accession>
    <name>A0A7W7SYG0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator YbjK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20734" checksum="D4D060992DFFF301" modified="2021-06-02" version="1">MVRNAERRVALVDAAIEVLAREGARGLTFRAVDQEAAVPTGTASNYFPNRDVLLHQVAERVHVRLTPDPAAVVEALSAPRDHALVRRFMRELLDRMRRERTGYLAVLELRLEATRRPELRASLTRTMSVTLEENFRFHAEAGLPGDRAGFEVLYLAMTGLLLEHLTLPDVLADVEGLVDAMVDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYJ2</accession>
    <name>A0A7W7SYJ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="25496" checksum="9475A779F546EA55" modified="2021-06-02" version="1">MIEPEFLLTPRQLDVVWHDLGAGRLPYPLDVPSLGGTEEDRARLRDEVGQPSPRLADLLLLLGRGRVAVDGVADLGRVVRAVAVSDGARAVLAVIDDDRIGLLEVRPTALAHAVVEILPDGTAGPGNALSLPVTALSQAVTQDFAESDDPWGDAGLGEREALHRAGVSREDATALTELAAGRVAGGQFGVSVGGSRVGALVTWFDTAHGRYLMVNEHGWLSLAPTDNDRIAHRLTTVLSAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK3</accession>
    <name>A0A7W7SYK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12256" checksum="BD4EB1430B1C4707" modified="2021-06-02" version="1">MNPSLDWAAGEMTSTADDLSRFLDALLGGRPTSPAALAAMRTTRPTGSLFAYGLGLQRFDLPCGRSAWGHGGELVGYLIYALRDDDGERAVLSYDPLPGGVPGESLATLFSTVYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYL1</accession>
    <name>A0A7W7SYL1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
            <ecNumber evidence="6">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="19"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="45449" checksum="28F5FEFB986A91A4" modified="2021-06-02" version="1">MTLAPAAQAHGNDHDRDKPRTVGYYTAWSGYDRNFLVNDLVKNGTAARLTHLNYAFGFLDAEGKCYSPDPDADFKRQFTAAQSVSGKADVAGQPLAGNLNQLKQLKKKFPKLKVYISLGGWSGSKYFSDAALTPESRAAHVKSCVDLWLKGNVPGLKPGAAAGIFDGIDLDWEWPSSPANDGNVIRVEDKVNFTALLREYRKQFAPLSWRNGKKYDLTAFLPANPGMLDRGFEVPKVFSLLTFGTVQGYDYHGGWDSTTNQQSALRTPAGDPTNSNFSTQVVVDHYLKSGAPRSKIVFGVPFFSRGWTGVKNENNGLFQPVSGPAPATYEAGQEDYKTLKAQLSKFKVYRDEKAGHAWLFDGTTFWTWDDPTELKRKGRYISDRKLGGAMIWSLDSDTADGELIRALQSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYN7</accession>
    <name>A0A7W7SYN7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family leucine-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16183" checksum="21596EE0F9476548" modified="2021-06-02" version="1">MDALDRQIIAALRENGRATYADLGRKVGLSASAVHERVGKLEATGVIVGYHAVVDPSAVGLGVTALVGVHPTDTADDDEVADSLGELVEVESCYRVAGDESFIVKVRVATVDDLERALGRLRRIPGVARTRTTVVLSTRFEGRPNNTGTEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ8</accession>
    <name>A0A7W7SYQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin--NADP+ reductase</fullName>
            <ecNumber evidence="10">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="45354" checksum="DFCE27620608D74E" modified="2021-06-02" version="1">MRFAVVGAGPAGVYSAQELLAGAPDCAVDVFDRLPAPYGLVRYGVAPDHPRTKRISTVLGRTLGDPAVRFFGNVTFGLDIGLRDLLACYHAVVFAVGADDEPRLGIPGEDLPGVGSAGRLVSWYNAHPHADDAFPRRVLAARDVAVVGAGNVALDVARVLVGGPDRLASGDVPEDVLKSLADGNVTDVRVIARRGPAHARFTLPELTELGRLDDVDVVVDPADLSDGDQVRGRGRSVWELLREWSSRPLSGAPRRVHLLFHRRPVEVVGSRLGVERAGVRSDLPAGAVVRAIGYRGRPLPGVPHDEVTGTIRNRGGRVVDATGVVVPRLYAAGWIKRGPGGVIGTNRADAAATVRAVLADAAGFPVPFQVGASTVPVLLHKRNVRYVTWAGWLRLDAHEIDLGRVHGRPRVSVGDLATMLSVARAGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU8</accession>
    <name>A0A7W7SYU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10754" checksum="F5493DC3080D7F89" modified="2021-06-02" version="1">MADAVRGLSRFGWDRDVESVVVTSAHVVGVLGRYLAGALSAEDVELWAEALAGRDDVGFVEGTEDELKQVLFELSTPEINWPIGPAMASGWITRLQVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ08</accession>
    <name>A0A7W7SZ08_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase</fullName>
            <ecNumber evidence="7">2.7.8.33</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.33" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036380">
        <property type="term" value="F:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="39352" checksum="24DE03AC7620285A" modified="2021-06-02" version="1">MREYLLVALTAAVVTFLLVGLVRALAFRIGAVAYPRQRDVHVKPMPRMGGLAMYGGVIGGMLLAHQLPVLRSAFDFSDDPYAVMIGGGVIVLVGVLDDRFELDSLTKLAGQVTSAGILVLFGLQWLVFWVPWGDDGAGTGSVLALDQNQGALLSVLLAVTMVNAMNFVDGLDGLAAGIGLIAAIATCAFSIGLLADNGGEVGAYPPALIAATLAGACLGFLPHNFNPARIFMGDSGSMLIGLMLAAATTSASGKINYSSLDATDLLGLLSPLVVVAAVLFVPMLDLLMAVVRRTRRGESPFSADKMHLHHRLLEIGHSQRRAVLLIYLWAGVLAFGAVALTLFDDAVVLWCLAIGLLLALLVSAIPRLREPRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ66</accession>
    <name>A0A7W7SZ66_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031016530" evidence="6">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="471" mass="49954" checksum="033BBB21DAC5CEBE" modified="2021-06-02" version="1">MVAAVAVLGLLSACTQQIAGVARTERPDVSKVAGLDITTGESGPKPGVPDADLRVENGDGGEMDRLSTNALADVEEYWSEQFPKQFGTRFESVKRLVSYDSNGAGVEICRTNTKGVANAFYCSLDDSIAWDRGELLPMLDDMFGPMSVVTVLAHEMGHAVQYKLGDKGGITQATPSIVKEQQADCYAGNFFRWVAEGKSAHFRISTGPGLNQILSTMFFIRDAAGTSAEKQGAHGSAFDRVAAFQFGFAGDPKRCAQIDPDEIRSRITQEVFDPNERDLGFGKGNLPVNDRKSLDLLESSLRDAYKQSGATPPALKVGESSCPDAQPTSPASYCPATNEISVDMPELVKIGTPPKRGQKGGIGDFAAFAEIASRFALSIQKATGYALEGPAAGLRTACLTGAWAGTTTKEGVQLRLSSGDLDEAVAELLADKSLIAADVNGTVVPSGFARVEAFRDGFFEGSGLCTRKYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA9</accession>
    <name>A0A7W7SZA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidohydrolase</fullName>
            <ecNumber evidence="1">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="44615" checksum="8FA404A12E7528A6" modified="2021-06-02" version="1">MTVVDSRPSLSGEEEGPEVLLTERGVSIAPVDDPGTGRGPSWLDDWLSANSSEVVAWRRHIHQNPELSRNEVATTEMIADVLRSVGLKPRILPGGTGLFCDVGTGQRCVALRGDIDALPLTEKSGAPYASKNPGVMHACGHDAHATVVLGAALALASATELPGRIRLIFQPAEEVMPGGALDVLAAGGLDGVERIFGLHCDPRLPVGRIGTRIGAITSASDLIELRLTSPGGHTSRPHLTADLVNALGTVITGLPALLSRRVDPRSGTVMVWGAVHAGEAANAVPQDGVLRGTLRTGNREIWAELEPLVKEFVGALLAPTGVGFDLLHRRGVPPVVNDRESTMLLRAGIEAALGEDALAGTEQSSGGEDFGWYLEHVPGSFARLGVWDGVGKQRDLHQPDFNLDERALMVGVRVLVHAALASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF8</accession>
    <name>A0A7W7SZF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="9274" checksum="D30AF72AA3CE5C4E" modified="2021-06-02" version="1">MSSDPAAITIHLGIGGLDRNEATAVLRAIPAGRSATFDVTQPALGGPRYDVTLHDLSSVQARDLLAAHITAAEAVWNTGNGDGTAPPAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY5</accession>
    <name>A0A7W7SZY5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="10" type="ORF">F4559_001431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="165"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="469" mass="50778" checksum="DC1C3105271A500D" modified="2021-06-02" version="1">MSSPTTAKRVSMLTLGCARNEVDSEELAGRLTAGGWRLVDDGEDADVIVVNTCGFVESAKKDSVDTLLAAADSGAKVVAVGCMAERYGTELAESLPEAQAVLGFDQYANLADRLDDVVAGRKVESHVPVDRRTLLPITPVQRQEKAQDVEVPGHGWGPRVLRTRLEDRPVAPLKIASGCDRRCAFCAIPSFRGAFVSRHPDEIVAEAEWLAAQGVREVFLVSENSTSYAKDLPAELGGLENLLERLAKVVDRVRVSYLQPAETKPSLVKAIATTPNVARYFDMSFQHSSEKVLRRMRRFGSTDSFLALVQQIRTLAPEAGIRSNVIVGFPGETEEDVAELERFLTGARLDAVGVFGYSDEDGTEAEGLDGKLDADTIAERVARISNLVEELIAQRAEDRVGDEVVVLVEHEEDDESDCVGRAAHQAPEVDGECVITNPEGLSVGDLVRCRVDAAEGVDLVVTALEVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G6</accession>
    <name>A0A7W7T0G6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Anth_synt_I_N" evidence="6">
        <location>
            <begin position="222"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="395"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="667" mass="70941" checksum="B2F068969F94208C" modified="2021-06-02" version="1">MRTLIVDNHDSFTFNLFQYLAEVNGREPVVVANDDPRFRLSDLRRFDNVVISPGPGRPQRAADVGLGRSVIEHADLPLLGVCLGHQALCLAHGAPVDLVPPRHGVVDTVTHTGVDLFAGLPSPLSVVRYHSLAVTSLPSTLEAVAWSADGVLMGVRDRTRPAWGVQFHPESVGTEHGYELLANFRDLSGGSAGAYSPVVTAAVVPPVAAGVVVRRVDAHPSPEAVFASLYGASAEAFWLDSASGGRFSVLGDASGPGARVARYSVESGQVTVDGVTHPGPFLDWLEADLAAHRVAVPDVPFDFHLGWVGYLGYELKAECGGTVAHRSAVPDAAFVFADRALVFDHDERCVYVLALPDSDDGWVARTVAFLATFRGVVPAPPGPVEVADLRLRHGREQYLKLIAACQEAITAGESYEVCLTNEATATGVVDPFEAYRFLRTESPAPFGALLRFGALSVLSTSPERFIRVDRTGVVESEPIKGTRPRGRTPEEDEALRAALAGSTKDRAENLMIVDLVRNDLGHCAQVGSVTVPAIFEVRGYRTVHQLVSTVRARLRDGSSAVRVVRAAFPGGSMTGAPKIRTMQIIDDLEAGPRGVYSGALGYFSASGTADFSIVIRTMVVDGDKLGFGVGGAVIALSDPVAEFEETAVKATALLRLLNSSFPGRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J5</accession>
    <name>A0A7W7T0J5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20937" checksum="5EE80AB6B0DBDF70" modified="2021-06-02" version="1">MKWYADRPVRLVRQLVADVLAAAWTWFWVTVALGVRDAVLTLRAPGEALASAGRSLGDTFAEAAAKARDVPLVGDNLADALGRGDGAGDTLATAGTTQIEAVETTALWLTVAFIAVPTAFLLLLWLPVRLRYARRAGAARRLRAAGRMDLLALQALTTLSPTALSRFASDPAAGWRAGDPDTVAALAAHRLRTLGLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S9</accession>
    <name>A0A7W7T0S9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YkwD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030525279" evidence="1">
        <location>
            <begin position="31"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="119"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="23696" checksum="53BF42C596381817" modified="2021-06-02" version="1">MTARRGNRSVIGILVGLLLGAAGATGVAVASPAHFTSVGDEPDDATSHAAGAVGAPSSTTVAVPATTTASRTATVTTAPVTTTTTVTTTTTTVATTTTTVAPTTTTRPADLPAAAQVVELVNGERASAGCPALKVDDRITAAAQGHSADMAERGYFSHDTPEGVDFAARMRTAGYSRPGGENIAKGQRSPEAVMSAWMNSDGHRRNILDCSFTAIGVGLDTRGWYWTQDFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V2</accession>
    <name>A0A7W7T0V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="11729" checksum="B8FD6E6BA1F1B485" modified="2021-06-02" version="1">MVSPRFLPFVAALSLSVVVLFMPQSGVPSSWPGMDKIVHLGLFALLAVTGLFALPRTPVLVGLVGYAVLSEVLQGLLIVLGRSADVVDGLTDVAGIGLGWLAYRVVSGIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T100</accession>
    <name>A0A7W7T100_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+(H+)/acetate symporter ActP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="573" mass="59920" checksum="F4763C6A98748EE5" modified="2021-06-02" version="1">MSSTYGIIAVLVVAVGTMSVGTYGLRISRTTSDFFVASRTVSPWWNASAIGGEYLSAASFVGIAGLIFAHGPDMLWFPVGYTAGYLVLLALVAAPLRRSGAYTLPDFAEARFASPVVRAVTSVLALGIGWLYLLPQLQGAGLTLHTVTGTPDWVGALVVAVVVTANVISGGMRSITFVQAFQYWLKLTAIAVPVVFLVVAWHAHGARDLDGPGFPAFPSDTTVAFDTATAFRVQEPTTYAGVGEVDGTRVDGGGMLWAGDHTVAAGSRLTFPKGAAVPHVDSIPSATNDDWALPMRGGERFPLYAVYSLIIATFLGTMGLPHVIVRFYTNPNGRAARRTTLIVLGMLGVFYLMPPIYGALGRLYTPELLMTGDTDAVVLVLPSRMVDGLGGQLLGALVAGGAFAAFLSTSSGLMVSLAGVLSRDVLRLRGIRGFRLSSIIAVLVPLGMSLLVGKVPVADMVGLAFAVAASSLCPLLVLGIWSTRVSTVGAVAGMLAGGVPALVAGLVTISSGGGTGWYHVFLARPAAWTVPLGFVVMFVVSLLTPRRVPPGVNHVMVRLHAPENLGLRSQDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q7</accession>
    <name>A0A7W7T1Q7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase</fullName>
            <shortName evidence="8">L-Cys:GlcN-Ins ligase</shortName>
            <ecNumber evidence="8">6.3.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mycothiol ligase</fullName>
            <shortName evidence="8">MSH ligase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mshC</name>
        <name evidence="10" type="ORF">F4559_002304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26176"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.13" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035446">
        <property type="term" value="F:cysteine-glucosaminylinositol ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01697">
        <property type="entry name" value="MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017812">
        <property type="entry name" value="Mycothiol_ligase_MshC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03447">
        <property type="entry name" value="mycothiol_MshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="9">
        <location>
            <begin position="38"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteinyl adenylate binding" evidence="8">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'ERGGDP' region" evidence="8">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-cysteinyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:144924"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="45132" checksum="9261028A2D5BC55E" modified="2021-06-02" version="1">MQTWSAAPVPRVAGEPRPLRLYDTATGEVRPTAPGATARLYVCGITPYDATHLGHAATYLAFDLVHRVWLDNGHDVHYVQNVTDIDDPLLERAERDQDDWVVLGMRETALFREDMVALRVLPPRQYIGAVEAIPEIVEAIAKLLADGSAYRVDDAEYPDVYFDKSATGRFGYESNYDEEKMTALFAERGGDPDRPGKRHPLDALLWRAARPGEPSWPSELGEGRPGWHIECSAIALNRLGTGFDIQGGGSDLIFPHHEFSSAHAEALTGEHPFARHYVHTGMIGLDGEKMSKSRGNLVFVSKLRAEKVDPNAVRLALISGHYRTDRAWTQVLLEQAQGRLDRWRRAAALASGPDATDTVARLRDHLGNDLDTPSALAALDAWADAALTSGGSDLTGSTLFRAAVDALLGVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T3</accession>
    <name>A0A7W7T1T3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase F4559_002361</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="92"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="44108" checksum="E3EDAC59F955F87D" modified="2021-06-02" version="1">MTTHDIRVLDDESDHRAAHTLFRRTLHRGPAPDGPWAFLRDAYEPGRALGAYGDGGLVGTVQSFPSSLAVPGGAVVPMSAVSRVGVRADWTRRGVLTALQRVQLRSFRERGDVAATLRASEAGIYGRYGYGVASRFRKVTIDRLRMGALPKPTGRVRSVSAADGTDVLREIFEQVSPVRPGTIGRWPGWWAQNYARVVGTDEEPQVAVRSGESGDDGYVAYVVDSGGHDDGEDRPATLTVADLWARTPEAWVDLWLFVLGVDLVRTVTAADRPVDEPLEWLVGDRRAVRTVDVVDETWLRLVDVPEALARRTYAPVDDTVVLGVRDAFLPENDGAYVVGRSGVERTSAAPELVLDVDRLGSVYLGDLSFADAAAARRVEVVDPTAPARADRLFATAEVPWCGTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U7</accession>
    <name>A0A7W7T1U7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="39998" checksum="4E41935DA28503EF" modified="2021-06-02" version="1">MGTGFRAAFAVPEFRVLWSAAALSTIGDQLARVALSVLVFERTGSAAWTALTYALTMLPALVSGVLLSGLADRFPRRTVMVVSDALRAVLLGVMAVPGVPLSLVAALLVVAQLAEAPFSAAQGALLPTVLGDRYEAGQSVHLITHQSGLLLGFVGGGLVVAWLGTSGALAVDAATFAVSALVLRLGLVHRPVSGVVKRTHVRIREGAALVWRDRRLRLLVTLGWLALFTVVPEGLAAPFSAESGIGVEGVGLLLAADPAGMVLGTVLLRFLPTDRRVRLLGLLAVATALPLAGYLLAPPLAGAVALLALSGVFSAYQVTAGATFVRLVPDEQRGQALGFARSGLVAAQGVGVAGGGLLATATGSAGTAIAVSGVVGAVLAALVTLAWSRVSVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T216</accession>
    <name>A0A7W7T216_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">VIT1/CCC1 family predicted Fe2+/Mn2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="23917" checksum="73493EF043DDB4EA" modified="2021-06-02" version="1">MAHPEPQALLSQRVNRLRAGVLGANDGIVSTAGLVVGVAGAAADRTALLAAGIAGLVAGALSMAGGEYVSVSTQRDTERAALRLEEFELREMPEAEEHELAAIYREKGLRPELAAEVARELTAHDALRAHAEAELHIDPDNLTSPWQAALASCQAFALGALVPLLAIVLPPVAWRVWACAAAVLVGLALTGVVSARLGSSPVGPAVRRNVVVGTLTMAVTYGVGLLFGVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T247</accession>
    <name>A0A7W7T247_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 2 lantibiotic biosynthesis protein LanM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04792">
        <property type="entry name" value="LanM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017146">
        <property type="entry name" value="Lanti_2_LanM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037228">
        <property type="entry name" value="Lant_mod_RumM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03897">
        <property type="entry name" value="lanti_2_LanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="104"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="948" mass="101304" checksum="C35FD7405E5A2706" modified="2021-06-02" version="1">MTHDEVGGLDRTLDWLVGPALSRTASGLAEVAGLAVTEADAVLAATREALLDVLRRKVIRVLVLELNAARVTGRLTASDPEGRWREFVASAQRPEFWQDLTKHYPKLVDRLTAVTDRRVAAVLAFARRFAADRDALTDLLGGPAGELRAVEIGAGDSHHGGHTVVIVRCTGGTVVYKPRPMEVDRELAGLVSVLSDAIRVPRAVVRDGYGWAEHVDHRYCADETELVRFYRALGHWLAVMRLVSGTDLHAENLIAHGPVPVVVDCESVFTPRPAHPSTGAGEATDLVAEQLTGTVMRTGLLPGRGAGLGWRGVDGSGMGGLPGEQPEIGIPDLVGAGTDTARVETVPHRVPTTANLPSPEPDLVRYWPEVVAGFDELAERITALDKAGELEQALYRFADVTVRVIVRDTESYTELARMLWHPAGLHDQDAAELKARTLLARHSMNTRGPGDPDVHVAEVADLLVGDIPVFTTTPAEGTLHTPGDHRCMPRADQIALALRRWRDADFALERRVTQAALVSAYLNQGGTPDLHRMSEPTSNRSDVDGRRRVLAARLVRELLGEAVRGTDGTATWFAPVLDRGGWQTTPLTPDLYGGTLGVAVLLAGYRNEVAAGRADEVDGVDDLLAATVRTARLTQEWWMAQLAHTKRRPDPVGAYIGLGSQIWCWLTLHRLGLDCLPDALFLADHVPAALAASEGPDLVVGTAGAIVPLLALAARTGDRRWHALAVEAGERLVATALVEDGKARWPAPTWPGGIGGFAHGATGIGWSLDRLVLAGEERFAEVARAAAAFEESVYDPDRQGWPDPRAADTLAAAWCHGAVGVGLAQADLLDRGGPGSRGVLRRAAESALRDGLGWTHTLCHGDSGTWELLVAALDHGVAPEGLDRAAVDARLIGGLEAHGAVTGLAREVYSPSMMSGSGGIAYQLLRLHPDCALPSVLVLADADGTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y7</accession>
    <name>A0A7W7T2Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="30812" checksum="7D2A52731BEDFC48" modified="2021-06-02" version="1">MLDVRRLRLLRELSRLGTIAAVAELLAYTPSAVSQQLAALEREAGVALLERTGRRVTLTPAAHGLVVRTEAILAELERAAADLAVARTTLTGTLRIGAFPTAVRTILPPALVALSRDHPGLELRIGELDPADVPDALRSGVLDIGLLQDYGHAPVAPPDLDSEPLLTETVLLASTDGGDLADHRDSPWIVALPGTLCHDMTMRACEAAGFHPRVRHYTDDFGALLALVAADQGVAFVPDLGTVGAPASVLLRPLPIIRCTATAYRRGSAGRPGIAAARAALLAAARSHAARPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T310</accession>
    <name>A0A7W7T310_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="135"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="831" mass="89121" checksum="4584EBA6479BCAA1" modified="2021-06-02" version="1">MTDLGLPDPTTATDLDGLVTCLRLLKVWAGDPSYAVITTRVAGLWRDRGEVPRRSTVADCFRTGRRRMDEELLAAVVHVLRPDAGYVEAWRSALRAMRGDAVRAAIVAAYDDLPPDPPGFVGRAADLAIVEAGAPLVVVHGMAGVGKTRFAVHAAHRLTRRGYGRDVRLFVDLRGFDPVAPPADPAAVLGEFLRALGVPGDRVPPGLEARAARFRDLLRGASALVVLDNAADAASVRPLLPDGPHCVALVTTRRRPDEPAAVRVELDAFDAAESLDLLRRTAGGHRVDQDPETATRITELVGRLPLALAIAGSHLRDHPDWPLVDYLESLTGLALEGGARAALALSDRGLPADARAALRLLSLHPGPDFDAHAAAAVAGSPEVGPLLAALTAAHLVQRRGDRYGLHDLVRAYGRERAAIEDPPSRTRAAVGRLFDRYRFAALAAVDLLYPFEKGRRPRLAAVTPDLPTPDTVEAARAWLDVELPNLVAIACHDARRWPEHTADLATILNRHLDTVGRYDTVVALQEHVLVAGRARGSRLDEGHALMNLGISAARQGSYDRAGAYLARAVEAYWDAGDVVAVGRALGNLANVHTLKGRYEESLSCHEEALRIARDTGDRLSEGRVSTNVGLVSRYLGRHEDALVHYERSLEITREVGDRTGECLALDNIGHAHRLLGRVEEAVPLHVEALAIAREAGFGYGAGLALANLGAAQAALGRHDEALTYYEEASAALEATGDFERIGVLNDTGGVLLTLGRAAEALAHHEMALAAADDIGERREAARALTGAGDAHAALGAPEEAVSHWTRARDRYATDPEAAELDHRLRTVRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T395</accession>
    <name>A0A7W7T395_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="23594" checksum="23F26E72A6B29498" modified="2021-06-02" version="1">MLTQPARATAAAGALAVVLTVVLVGSLDACRATVSTAFLRRTISEYALGPHRWVFDTAVVLLVLGSCAVLAVLVRRGIAKKSAAVAMGAWALGLTLVVLFPKHDWAVGPSASGTVHRVGSLLAFVSLPIAAILLAKPWTRHARWGGHARWTLGMGVLSALSFSPLLYAILLNATTGTSWWRVFPLGYVERVLVLTEVATVLVAALWAFAVAQPSYRLSRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T399</accession>
    <name>A0A7W7T399_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="41045" checksum="056A47091229F79C" modified="2021-06-02" version="1">MSDPWFSRLWAASTATMLGDGIRVAGLPLLTAASTGSPTAVSLVAVAVHLPWLLFSLFGGVLVDRFDRARLLWLSGVAQAVLVGGLAVLVHRHPPGLVTLVVLAALLGCAGTVHLTASGALLPELVEADELDRAHGRLQGSQVAARQLLGPLLGAVVFGFAVWLPFAIDAALFLLAAVLVRPLVGSNDRTRAEDRVFAETRSGVLWLSRHKGFRLLAVGLGVAALALQLGTTLLVLLVTGTLRGSVAAFGIVLAVGAVGGVVGGVTAGRLRARLGLAAALSGALLVMGVSLLVVGVSGSVAVVAVMCGFGGFGAVVWTVQASALWQRVLPRTLRTRVGGVYRLIGWAGVPVGAALSGALATVTTLRVPFLVGGVLLLLTTALVPALARLDATPTPVPNPQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3A4</accession>
    <name>A0A7W7T3A4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="28815" checksum="F04E4D89F1062CCD" modified="2021-06-02" version="1">MLDVFITGASGYIGSAITRVLVGRGHRVRGLARSARAEAVVRAAGGEPVRGSLTDLAVLAGAVGDAVIHTAATDTADRPVVDEAAVTAMLAAGPAVFVTTTGVPRARSSRVPVAEDDTAAPEGPLAWLADAEDRVLTADVRGVVVRPPMVYGAGGGPVARLVGQARADGVARYVDEGANVWSTVHVTDLAEAYALLLETPARGVFHAAEASPVALADLMAAVGHAADVPVRSWPLSEALATHGPMAGFLAMDAALDAGRLRDLGWTPTTGDLRGGVVGDLRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I2</accession>
    <name>A0A7W7T3I2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="33666" checksum="76DE6191F337851B" modified="2021-06-02" version="1">MPKAVVVRTPGGPEALEYTDVDAVAPGPGELLVEVAAAGVNYIDTYHRSGAYPLPAPFGVGLEGAGRVVGVGDDVGTVRVGDRVAWASAQGSYAERVVVPARNAILVPEGVADEVAGALPLQGLTAHYLVRSTFEVGADHTILVHAAAGGVGLLLVQLAKARGARVIGTVSTEAKEALAREAGADEVIRYDRTPFAEEVRRLTDGEGVAVVYDGVGAATFEGSLDSLRPRGLLALFGAASGPVPTFQPQVLNQKGSLYLTRPSLNAYTATREELDWRAGELFGAVADGSLTVRIGGRYPLADARRAHEDLEGRRTTAKLLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T469</accession>
    <name>A0A7W7T469_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DO-GTPase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045528">
        <property type="entry name" value="DO-GTPase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19993">
        <property type="entry name" value="DO-GTPase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DO-GTPase2" evidence="1">
        <location>
            <begin position="88"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="359" mass="40178" checksum="2C9A6173516316A2" modified="2021-06-02" version="1">MTTSSPPPQPALLCPICLDFIGWPEPPLFQRVDDSEASRWEEVDLSGINNEVKYADARRRCYVRCPNPSFDTGEHFLPVSHRDHGDPIIIGLVGRGQSGKTHLLVAMMSEALRAGLAPFGLELEPADEFRNLRFMRNVEKLAAGDRLDGTRGSIQDFAAYYVVRTRSGTSRPLVFFDVAGEDFMSHGNQGRNARFLLGATALMFVEDPEHAVPDWYPDHRSPDTQQNQAFAVALSRLRSRGDIRRIPVAVVVTKADELRYTHPVDRWLRRYDTGPDSLTAFREESRDVYAFLHHYGAHPLLDVYDRFDRGTLHVVSATGSRADGNGYPRVRPMRVLRPLVALLAMVGVVEDPAADGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T488</accession>
    <name>A0A7W7T488_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular small neutral protease</fullName>
            <ecNumber evidence="3">3.4.24.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Snapalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031166549" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="27"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="19397" checksum="D01E70F4A5119E7F" modified="2021-06-02" version="1">MMLRLKSLPLLLALAVGLVAAPTATAAPTATAAPRQAVRTIYYDSSRAAELASQVEEAVKIWNAGVTSVRLVKGSGGVTVTTAQNGSAPGTASCVGCTRGQIYFYRNQITQSGAAPLRVVVHEFGHILGLNHPQDIGNCDKVMAGGRCANPNPNAAELAAVQRYWGGFRVEGSTVPEEQGVHEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C3</accession>
    <name>A0A7W7T4C3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LmbE family N-acetylglucosaminyl deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030661996" evidence="2">
        <location>
            <begin position="24"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="617" mass="64955" checksum="83B5B5DCC5CDCA81" modified="2021-06-02" version="1">MRAFGILAAVVAITLGTTPPARAVPGDLYLQVVAHEDDDLLFMNPDIDQTIRTGTDTVTVFVTAGQITGAGDTDEIRARNRQRGIQDAYARMAGVPDLDPNAQEEWTGDLLAVAGRQAERYVLTERPEVALLFLNLRDGRLGAVRDSGVTDTTVIPAGGLVTRSFSYDRAGVTAALADVLRLYRPSLVRAQDPLPDARYQPDHGDHVAAARFTDDAVRAWGGRPVQVNYRDYNNVDVPGNLSPGTLDRKSSVFDNYLRYDGNTGLRALLVGMNVRWPRGTGWAGRDADGRARLFVVRAGVAVTYTQNAAGGWDGAVALPAAGGPLAPSIVVGRNADGRSEIVARRLSDHHLLGLHQTTPNGGWAGAWTDLGNPNTSGADQVGQPVLAANTDGRLQLFVKNGGGGVSTRFQTTPNGPWGDWVDLFGTDVQDGLAAITGPQGRIELFAATRQKILHWFQASPNGSFARNDNLPSAVPAGPPTAALSQDGRIEVLYRGAGTEHVVASVQREVNGGWYSTPVVLGGHGGVGSVATVTGPGGRIVAVERNAGTGVSLTTQRGPNAGYGEWVDLGGVVADVPALTLDARGAVVVASIGTDGALYVRTQGEPTPDSPFGPWVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4H1</accession>
    <name>A0A7W7T4H1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="3">
        <location>
            <begin position="108"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="937" mass="100485" checksum="ABC7A504FCC20C86" modified="2021-06-02" version="1">MEREDHDSGPPPVDARVFGAVEVRVGGRRQDVGHARQRAVLAVLLVEAGHPVPVDALVDRVWGERAPSRARSVLRTYLARLRPALAPGGITITHRSDGYLLDVDRDAVDLHRFRRLVAEARGTRDPARALVVFGQALELWRAEPLAESDTPWAEAERRRLHRERAVAEADRADRALDCGRHHELLPELTARAEADPLDERVAAQLMTALYRAGRQADALHHYQRTRHHLAEELGADPGPALRELHRRMLAADSALDLAAPGTRAGTPVVPRQLPAAPRSFTGRTAQLAALDAALADGGLHTIGGAGGMGKTWLALAWADRDLDRFPDGQLFVDLRGFDPTGQPVGPAEATRVLLTGLGADVDGLPSDPDELTARYRGLVAGRRLLVVLDNAATAAQVVPLLPGSTSCTVLVTGRAILPSLIDRHGARHLHLDVLTHDEAHALLTARAGAPRVAAEPGAVDELIESCGRHPLALSIIARQAATRPGVPLGEFAAELREAGLEVLDHDTDPTASLPAVLSWSLHHLGEAQRTLFALLGIAPGPDVDTLAAVALAGLPAARTRRDLRALADASLLDRQAGGRYAMHDLVRAYAATTADDLLPAPARRAALDRVVDFYLHTAHAADRVLDPHRDPVDVGPPAPDVRPLSVSTAAEAMHWFDAEHRHLLDAQRVAAAQGRHHAVWHLAWASSGFHARRGLAGDDLAAWQAAVTAAPHLSDPGAVGLAHRRVGRALAGLGRHEEATGHLGHALAAAEHHGDLAQQADAHGMLALAWALRGDHRRALVHTDRSLHFYRLLDRPVGQARALGDLGWFSALLGDLDGGRGHLVAALDLLGRHPDPATEAAVLDSLGYVDHTAGRHAESVAHYRRAAALYEELDYTAEHATTLDNLGRPLCALGRFAEARAVWSDAAERFRAQDREADADRVRRRIGELVADGGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S0</accession>
    <name>A0A7W7T4S0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5555" checksum="2E86E5A54BFF819A" modified="2021-06-02" version="1">MLIFLGLVLLVIQIVLLVRYGKSDDDPNRRKGLIVGTATLLVCAVLLFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S2</accession>
    <name>A0A7W7T4S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031255756" evidence="3">
        <location>
            <begin position="21"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="609"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="691" mass="71457" checksum="C9AF0AFA4FD6A2A1" modified="2021-06-02" version="1">MRRLPVAMLVALLVVAAATALFLGGRNDPQVPTAFLDAQRDTAESAARSVGATASQALADLRTAAANPPGDPAALLDKAARARTWLGLTLFTDSGRTAAATRGKAVPATALPSVTTGGSVVALVAEDGEPQLLAVTPLDGGRVLAATTAIRLPQPVADDTLGQRFVLTTLSGRIAGSAGQQAQLDAAVAALATRAGRNAAGGPGVLLGTPDGDRTPTLAFARVTPSAAPAGLDLAVVVVATGTPYDGDEGSGLVPAALLALLAIVGFLVVRGVVTGPIRAARRDLLRVAAGDLATEPGRYRTDDVHRVVAAARECRDLIAGRPDAKPPRGRKVSARAVTIALAATLFAWSAGMLVQFRSDEVRIPDSVTAAVRSQTGMATETLRRSLNDSLSDLRDVVTTKDTAALNRALRDLNAAQPRYRSVYLVDKAGKAIATDGRDPLRDTETPATEPRLRQQNQDGRVPVIFAEVPLPDGAGSAIAELDLDHLQALLGRVPGHARLVDGDLRTIGSTDGYVAFAQVTEAHLREGVAKAKAGELVGATHSTPGGQVIVASAAVSGGEAGDLGWAVVTERPGAELALPLNETRKHAQLAALLVALIALFGHGWLLFTVLLPLHRLARSADAVVDGDVTSVIYPQRHDEVGTMASCLEICRQAVVHGPGRLGAVRRPRGAATDQTVLMGRIEEPVRRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U0</accession>
    <name>A0A7W7T4U0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly-gamma-glutamate biosynthesis protein PgsC/CapC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008338">
        <property type="entry name" value="Capsule_biosynth_CapC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14102">
        <property type="entry name" value="Caps_synth_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01759">
        <property type="entry name" value="CAPSULEPROTC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="16961" checksum="2A641E260AF6FFCC" modified="2021-06-02" version="1">MTDGTTLLPEVATLGLAIGLVFSLGCYLTTNLSPGGMITPGWLALTLVEDYRRALLVVVMSGVTFGVVKLLQRFVILYGKRLFAAVVLSGVLLQVTLFMLLQNGFPLLFPHQTLGFVVPGLIAYQLVRQPPVVTIVATSTVSAAGYGVLASGILSGLLPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T567</accession>
    <name>A0A7W7T567_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10461" checksum="FCFB163FA4089E1F" modified="2021-06-02" version="1">MPFSTDAEIPAVWTCPRHGIEHCLRIDDDSDWQPPKGKPPRTHYVMLLERRSVADLEVLVDQALAGIRRQRSSPYGRVPIGDRSYGFRFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T571</accession>
    <name>A0A7W7T571_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10687" checksum="33E2782D58593AE1" modified="2021-06-02" version="1">MHHHRDRQTTRVSPVQLDADPTGSPEPAPAEARHAARARLLHTPAQAAHLLAVRESWLRRMAGQQRIPCTLLGKHLRFSDKDLELIVLRGARPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T578</accession>
    <name>A0A7W7T578_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5100" checksum="8D2FF75E35A5487F" modified="2021-06-02" version="1">MDGASRVDLFAQADASRVRGRIYSGFGGQTDFVVGAPHSPGGHAVIALPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C8</accession>
    <name>A0A7W7T5C8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="421" mass="45849" checksum="48599505EED2DC34" modified="2021-06-02" version="1">MLKVSLEELDDLLGPGSAEATRKAPDVPQSEEVVASTRRSDVEGDPVDSGVVQDVVASTSRREWPPLGIVSGFVLTLGRKSTGLTQETVAELVGVDVAVVRDWESGRRPLAATGAGELLALSARLCRAGAPATIRRYLHEAIEADLVLSTGITAGATWVDPDRHPLAAAVHRRNVTNLITWPLTGHTPPQLDDLVRTAPAGPVSAYPLLHPDERTRFFDHLLSTAQRAGRAEEPLLRRQAVYLVGFDRRGQVADWLRDEWHRAGHRTITDGDVTGLLEARSASVALASTGENEHIHDFVDRTSGTQAEIANLNYWAYWIGELRDVRTDDSFMTDEDSRAWHGGALLTHLAGRLDPASPHLPLNLHTLHTLVASRPGLLDTHRRLRPALTTALDTLAAGDVLTRTGRDRVAGLRYALRLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G8</accession>
    <name>A0A7W7T5G8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="5837" checksum="ADC5A419D140DF0C" modified="2021-06-02" version="1">MTRAPLAATARAAGWPLPRPRSSRRVPVRSAARSMNRSVSRSAASCHDVAPAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V6</accession>
    <name>A0A7W7T5V6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="41739" checksum="E3784D2FD34054D6" modified="2021-06-02" version="1">MDFWGAVRTLRRRWYIAVPAAVVAVAVAAGVFLSIPTRYASSGVMVLTTPAAGGTFSQKVSPEEAVRINPLLAFDGSLATTSQILAQILADPKTREEGLGLGKNATDTYVATGGGQNGPFLFVSGESDTPEAAEKMVSTVMEFAQKRLKLQQEELKAPEPTFITSQIIVNPTEAEAKIGGKVRYAGAAFVLLLLLTTAVTFGADSILNNIKRKRERAERGDVDDDERPEDEERPDPQPRPTPGPQQQAPQQQAPQQQAPQQQAPQQPGPQQQGQQQHGQAPNGTPGGQRRPLPPAAPPRLPTASEQTVKVDAKSLNLPSSPLEGRPPAGGQSGQVHGGPAQNGGQQNGGQQNGAKPQPGPREPNKPQPTASERTVKIAAPRSNPTPGRPAGDDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z1</accession>
    <name>A0A7W7T5Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38434" checksum="279B4BEE22E57195" modified="2021-06-02" version="1">MIDIPLVDLRAQHEQVADEVAEGWAEVLKTTAFIGGRQVGAFEAEFAAYQGVPHCVGVANGTDAIELALRALGVGVGDEVVLPANTFIATAEAVARAGATPVLVDCVADTGLIDVTRIADALTERTKAIVPVHLYGQAAPIEQIRAVVGDLPIVEDAAQAQGARRFDVPVGGLGEIAATSFYPGKNLGAYGDGGGVLTKSDELAAAVRLLREHGSPRKYEHSVLGFNSRLDTLQAVVLSAKLRRLEGWNTARRAAAARYHELLSGVDGVMLPVTLEGNLPVWHLYVVRVAERDRVLAALHEAGVGAGIHYPTPVHLTGAFESLGHKVGDFPVAEAVAGEIVSLPLFAEITPAQQDRVAAALAEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T612</accession>
    <name>A0A7W7T612_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyaluronoglucosaminidase</fullName>
            <ecNumber evidence="4">3.2.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="3">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="636" mass="70108" checksum="A37DBA786FCAA52B" modified="2021-06-02" version="1">MRIAVLAVVIVLIASAVVWLFLRDDPDKVGAVPPIWPTPQHAESSGADIDLPDAVMIIADPEADDYTVQAAVDAFREAGVGNVSSLDYGLDAPREPMIVRLGKLDGANVKSAGVSLPQSIPAEGYFLSADKDAVVIAGADDAGTFYGVQTLWQLLKPDALPSVRITDYPSMRQRGVVEGFYGPPWSATEEMDQMEFYGRLKVNSFIYAPKDDPYHRDDWRRLFDKSREGQLTTLVEAARDRHIEFTYALAPGLSICYTSADDYDALTAKLRSMYDIGVRSFSIPLDDVWEDKWNCPEDERRYGPWTEEHLAQAQVELLNKVQGVFLPGLQDVRPLQTVPAEYFDVKDTPYKKAYREYLDKRVVMMWTGVGVTPTSIEVAEAADAEQVWGRKPLVWDNYPTTDFDTAAGRMLFGPYAERKPGIGAHLTGIIANPMEFAYASKPGVFGVAGFAWNDGAYDPAKSTRQYAEWLGGGDEKVVTALMAFFDLNHLAPVLDEPGQTWQPQAPELARRIASFREKWAAGEHGKAIDELTKYAETLAQAPGLIRTATTDDGFAQDATDWLDAADLWAQALLTTLKGLASRAGGDDAGAERWFAEAADLTTRAEDVVAPTRFESKVKIGDGVLDTFIREAPALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T648</accession>
    <name>A0A7W7T648_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="524" mass="57542" checksum="707818D5F79CF41E" modified="2021-06-02" version="1">MRVARTVLEQRIWDRQQTMEEFVDYVEVFARESGEPGTISLRHLHRLIAGRRSSGQPLGLVRPATARLLERIFRTGIHELLAEPSAEHSTGSAAEGVAVGGHPGLAEMLDWLDERAEWPLGESRRRVHTKLSTFEAGALVDRRSRRGRAGREQIVRALRGYYRRGLAGYEMYQARCGSRDVSTSILTRPEWLGHPVPLTPENDRLVLAGRRDASRKGLSEAVAAAAVARLAEWAALDVRVMNLPLYRLLSPDIGSAIDGTVGLVEFTEYALTADPLEGELIDAVARGAGTGALPLRGEFLPSLDAVVDLPGRVCAGGVLALCAIARPRDPYRGGPDFALLVQERSGHVLNATGRLAVVPKGFHQPLTDVRADAHVGATLLRELEEELFGRSEVDTVVGDGRAALPMHPDRLSAPMRWLAEEPDRLRMECTGFGFNLVSGNYEFASLVVIEDEEFWPRFGGMVEANWEASGLRLYSSLDDESLADLVTHESWSNEGLFALLQGLRRLSEIGGSRVRLPTFELSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6E0</accession>
    <name>A0A7W7T6E0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17580" checksum="48AA70434CF52212" modified="2021-06-02" version="1">MTVGPGVSGPERGRLSSGHGSRVSGCEPRHGDRGIVPAAQAIPTLAHPDTTTATPVRRTHSLMPHLDERHLRIALRQCGRRLSAPGADGMTLGQLRECATRLLPRLAGQLAEGTWRPGPLCHIRFPTAVVPTHRSRLYARTTFLNAAPVELASPGIGMRVVRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N1</accession>
    <name>A0A7W7T6N1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="3">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_ligase_A_C" evidence="4">
        <location>
            <begin position="220"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="39451" checksum="51950DD12FEB3CBB" modified="2021-06-02" version="1">MALPLSPPVQPMLATAVDAIPTDSDLVFEPKWDGYRCLVFRDGDDITLQSRSGKPLDRYFPEVVAALKRTLPDRIVVDGELVVAKDDKLDFDALSERIHPAASRIRLLAESTPASFVAFDLLAVDDDVLLDVPCVDRRARLEKAITPGDSLYLTPATTDADLAAQWFGLFEGAGLDGVIGKPAGSGYQPGKRVMVKVKHARTAECVVAGLRWHKNTEPGTAVGSLLLGLHDDRGVLNHVGVVGSFKAAERRALAAEFTSSIVAADHPWLVEPDGRRLPGEINRWRSAQADWVPVRPERVLEIAYSQTEGQEPVRLRHNGQFRRWRPDRTPESCRYDQLDRPARYDVDSVLRGEVRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W3</accession>
    <name>A0A7W7T6W3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding WGR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="SSF142921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WGR" evidence="1">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="51828" checksum="2CC49699093F7F8E" modified="2021-06-02" version="1">MSGTTYLELSETGGGAHKFYEVRVDGTEVTITYGRIGEQGQIRTASFADHDKAVKAAEKKIGEKVRKGYAPAVKGMRQRRAVSRRQIVSTRSTARQAPVLWRFASGAPAFGIFIGEDHAWVGNENGDVYTLTHDGRVTGRFGLPDSVKCIVADDFWIYAGCDDGNVYDLGAKVPRVAYEIADDVDIYWLDIHDGVLGVSDRKGGVTVVDHEDEFQWSRPANGDSAWMVRCSDEGVFHGHSGGVTRYSERGDRVWHSDTVGSVLFGWQERTEVFAGTSRSRVHRFAKSDGRETGVYVCDAAVFSCATSPDGEFVFAGDNQSSVYCFAADGTRLWKLATGCGSAFSMQYRDERLYLVTTDGSLACVDASPAAVHAAEQGQLPQRQDIKAGAIERVEATAEVEIVSHVDAGEGVVVECTQEGGRIRVHVVSDGYNRSWGVQFPKQIRVPGARYLVSEVLTSASGSFYRARGEIKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z2</accession>
    <name>A0A7W7T6Z2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="10816" checksum="A0F732C7CDFC7E79" modified="2021-06-02" version="1">MDADPIDELRRLLDVAADRFQPWLNRLAAEEGHDPGACGWCPVCNVAAVLKGDRSELAAKAAEHVVGLIAVLRAALDRPPAAAEDSPGPPHVQHIPVVRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T708</accession>
    <name>A0A7W7T708_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27040" checksum="2778979526DBCD18" modified="2021-06-02" version="1">MDHPELPPDLGRLWRVPPPKRLGRRAELDVDRVVRAAVELADRDGVDGATLQKVAQELGFTKMSLYRHIGSKEELFELMVDHATGPAPDLGRTGWRAGVRDWATAMRARFTEHPWITDVPISGPPRGPNAIGWMDALLHVLRDSGLDLGTQAGVMTLVSGHVRNALLLTRQLEAGRHGTGRSQAEVERDYGRALAALVDPARFPDAARLFAAAVFEPPPGPPVDPADHDFAFGLDLILDGVAAAVDRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I8</accession>
    <name>A0A7W7T7I8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="16923" checksum="74BC274DF29B2EAD" modified="2021-06-02" version="1">MAVGGKGVDAERLDREARELFRQLTPAPVTGHDKDGRPLSIPPGERLAEIGRRARFIAVSDALARAVVVILGREGVPAAVGHVQVDPAASGDEQVLGLLLDVGGVASVVPLRPGDPLLRGYAAVDGVIDLVGRELAFSVDLVAEDDGWVGAEAVAAGLLRARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P5</accession>
    <name>A0A7W7T7P5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ORF">F4559_005457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="24869" checksum="2AD887C8AE69DA61" modified="2021-06-02" version="1">MSESTVRVALVLPDLLGTYGDFGNAVVLERRMAWRGIPAEIVTVNFGQPVPSSCDIYVVGGGEDTAQTLAVRHLREHPGLQQAAARGAVVLGICAGIQIFGESFTRADNVTHPGLGLLDSTSHAGGSRAIGEVVATPADGLFEGFLTGFENHQGRTTLGPSARPLAHVKVGTGNDGKVEGAVQGRIVCTYLHGPVLPRNPALADLLIEWATGTKPSPLDLPAVTRLRTERAKAAGVGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T987</accession>
    <name>A0A7W7T987_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">F4559_006275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="704"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="768" mass="77447" checksum="925211837AF3D067" modified="2021-06-02" version="1">MSRHFLAEGLQLSGGDRGVVAVVAVVALAALAVGYVLLREVLAAGQGTPKMQDIAKAVQEGAAAYLNRQFRTLGIFVVVVFALLFALPAEDAGERIGRSLFFVVGAVFSATIGYLGMWLSTRANVRVAAAAKEAGGREKAMRVAFRTGGVVGMVTVGLGLFGAALVVLVYAGQAPKVLEGFGFGAALLAMFMRVGGGIFTKAADVGADLVGKVEQNIPEDDPRNAATIADNVGDNVGDCAGMAADLFESYAVTLVASLILGTAAFGTQGLLFPLIVPAIGVITAVIGVYTTRARPGEGGLTAINRSFYISAVISAVLCTVAALVFLPSSFANLTGPDSIKGVAGNPAVVAAVAVIIGIVLAGVILWLTGYFTGTEHKPVKEVGKTSLTGAATVILSGISVGFESAVYTALVIGGAVYGAFLLSGSVVVALFAVALAGCGLLTTVGVIVAMDTFGPVSDNAQGIAEMSGDVDGAGAQILTELDAVGNTTKAITKGIAIATAVLAATALFGSYRDAIEKAVKEAGQTLDSVTVSFSNVVSSPNVLVGLVIGAAVVFMFSGLAVNAVTRAAGAIVFEVRRQFRENPGIMDGSVKPEYGRVVDICTKDSLRELATPGLLAVLAPIAVGFGLGVGPLAGYLAGAIATGTLMAVFLANSGGAWDNAKKLVEDGNHGGKGSDAHAATVIGDTVGDPFKDTAGPAINPLIKVMNLVSVLIAPAIVTYTIGVDASDAIRYSIAIVATLVIVAAVVVSKRRGTAIADAPAEQPSNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T996</accession>
    <name>A0A7W7T996_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xaa-Pro dipeptidyl-peptidase</fullName>
            <ecNumber evidence="3">3.4.14.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">X-prolyl-dipeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes Xaa-Pro-|- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-|-p-nitroanilide and (sequentially) Tyr-Pro-|-Phe-Pro-|-Gly-Pro-|-Ile.</text>
            <dbReference type="EC" id="3.4.14.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.11" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008252">
        <property type="entry name" value="Pept_S15_Xpro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00923">
        <property type="entry name" value="LACTOPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031272286" description="Xaa-Pro dipeptidyl-peptidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="PepX_C" evidence="10">
        <location>
            <begin position="382"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="613" mass="66802" checksum="EC1999845A766882" modified="2021-06-02" version="1">MKGARRAALVAALVTLGFVPAVAHAATEEPVFRDGEAQPVFSATDVVKESLWVRAPVDSDRDGRDDEVYVEVVRQKATERGLKVPVVFLNSPYFSGGNPVANHNVDLELYVPNRHGGHDRRDGSVLKAEADERIAASVGPSAGPIISTRYESYFIQRGYAVVYGESLGTGKSSGCPTSGGRNETIGSKSVVDWLNGRATARDAAGKDVKATWTTGKVGMMGVSYNGTLPNAVASTGVKGLEAIVPIAAISSWYDYYRADGAVVAPGTYQGEDLDVLAEYVYTRTDREICKPVIADLVAKQDRVTGDYSSFWDERNYVKNAHKVRAAVLAVHGLSDWNVKTKHVAQWYEALRRNGVDHKLWLHQSGHTDPDTLRSAEWRRTLNRWFTHYLFGIDNGVDREPKSTIQREDRTTWTDEADWPAPGTSTARAYLGAGGSSKGALKLGQNYGRPVVESLRDDATQKAEALADAPSSPNRLSYGTRATSRDLRFSGTARVELGLSFDRPAANVTALLVDRAPDGTSHVITRGWTDPQNRVDESVTTPIRTGKQYRIEVEFQPTDYIVKAGHSVEFVLLSSDYDYTLRPKPGAGLSLDLKSTEVELPVVGGTAALRRAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A2</accession>
    <name>A0A7W7T9A2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="16252" checksum="0350732AC88C2B7B" modified="2021-06-02" version="1">MSQFSYPVSIKGVVVRDDRVLLLKNVRDEWELPGGRIEPGETPEECVAREITEETRWNVTTGPILDTWMYYINVAEKNVFIVTYGCHPEDDAEPVLSHEHKEVGLFTESEVHGLNMPDGYKRSITTWFARLRETDRELIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D8</accession>
    <name>A0A7W7T9D8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19012" checksum="6B1EE97EE392245D" modified="2021-06-02" version="1">MAVRDLMHPLISGRTSPRTFADAPVDVESMRVLFEAARWAPSHGNSQPARFLLGYSGDAVHERLLAVLRPKNRAWASAAPVLFAGLVMTVNEKGPLPNAEYGLGLAVENLALQAVDLGLVTHQMGGFDADALVAAFGLPPEVRPVVVVAVGRPGAPEGRERVRLPLSGTVFGEWGTPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G8</accession>
    <name>A0A7W7T9G8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="271"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="41219" checksum="BD7C236200D0F997" modified="2021-06-02" version="1">MERPLILDAARTPFGRYRGGLAGVRVDDLAALPITELLRRHPLDPARVDDVLLGNANGAGEENRDVGRMAALLAGLPPTVPGAAVNRLCGSGGEAIVQAARAVALGDASLVVAGGVEGMTRAPFVVPRPDRPFADRLEPVSTTVGWRLVNRRMRPEWTVSMGRAAEEFAVDLGLTREDMDLFALRSHRRASAAWDAGVHEGFAFTVHLGDGTAVRRDECVRPGTTLERLARLESAYSEKGPVTAGNSSPLGDGATALLVGSEAAAAELGLEPLAEVLGSAVTAVEPHRFPLAPVTAIRKLMTRLKVSGDDVDLWEINEAFAATTLSVLHHLPEADREKVNVHGGAIAYGHPLSASLARVIADLARHLRARGGGLGIAVAAIAVGQALAVAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9L3</accession>
    <name>A0A7W7T9L3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26412" checksum="453407B5F6018917" modified="2021-06-02" version="1">MTSTDPADHNEGQAADDTTVEQQVATGRERPRAHARGTTRRPGSLPISEGYRGLASGSIERSRLGAANRRRGAEAERRLAAWLRAHGWPHAERAVRTGYRSAGRLVVDPGDIVGTPLLVWQVKDQAREFAEAWLDETEQQRLGEPGSVPADLGLLVVRRRGAADPGRWWVWLPAAQLVALVADAPAPPLSRPVRLELVDLVLLLRAAGYGEPVDDHVDEDAERAGCLHNSAYVGDIDAVGDGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9L5</accession>
    <name>A0A7W7T9L5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="14">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">F4559_005099</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0186">Copper</keyword>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="16">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4967740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="34299" checksum="905101A64364562E" modified="2021-06-02" version="1">MGLKEGTRAARLAKVVGLVGLVGIGATGCSTDEVLRFGWPVAVTPQAEKMRELWTWSVVAALAVGVIVWGLILWSVAFHRKKSEELPRQVAYNLPLELVLIVVPTVIVAVLFYFTAVTQNYVTDKSEKPDVTVDVIAFQWNWEFRYPEFKTADGPVSTVGSSGEIPLLVVPSDKSIRFNLESTDVIHSFYVPEFHFKRDVFPLPKKNNQDSSFEITKIDREGSFVGRCAELCGTYHSVMNFEVRALKPALFDEYIGLRQKTNEKTGKPYTAAEALTEMDCGELCTPHAVTTKPFDTDRTVREASTGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA10</accession>
    <name>A0A7W7TA10_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="164"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="29233" checksum="72240FF6D5AC792F" modified="2021-06-02" version="1">MTPPEKPAGQDADKTAVITRPGAEAKKKAAKPDTPPAAEEPKPETEETRTVESPTDRVDAGKTEVESGKTEEVSATPPPWQRVTSEAPYAEATQVGPGDEVVPEQQTVALESPAYPASDPDTVAVPRPVPPGLSGGAPRTSVNLGASNGGRPTTGAARRPGRGPRRASLQIKRVDPWSVLKLALVLGVALFFVWLVAVGVLYGVLDGMGVWDKINNTANDLLQGNESSGDPLISAGRVFGVSAIVGAVNIVLFTALATVGAFVYNVSADLAGGLEVTLSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA26</accession>
    <name>A0A7W7TA26_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="41850" checksum="0136FFD31ACBFB19" modified="2021-06-02" version="1">MTRFGWLWASYAVSTFGTWLAFDAFTLIAILVLHAGPVQVSLLAAVGTAAGAVLALPLGPWIEHRRKRSVMIGTDLLRCAALLSVAAAFAFGLLGFTQLLIVSVVVAAADIAFVAASGAYVKWLVKPEDLLVANGRFESTMWTATALGPPLGGALIGAFGPITTVVLDAGTYLLSALGLRAIKAREPRPSLPRTRPAWSDLLDGLRHIMGDPELKPLFLNQIAVNALIMATAPPLAVLMLGDLGFTPLQYGLAFAVPCLGGLVGSRWSRRLVARHGADRVLRLFGVLRACWPLALAFVGPGIVGLVFVMVVEFGLITCMGVHNPILATRRQERTPDGLVARVLSTWSVGSKISIAVLTALWGVIAGVGGPRLSLLIAGVLLLLTPLLLVSRVRQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAE7</accession>
    <name>A0A7W7TAE7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="415" mass="41802" checksum="6D5CD488827AFDD9" modified="2021-06-02" version="1">MGYREIGDHRFEGYDNHALAGLVEKFKSGDAAQRFSEASHALRELAAGLAETDEVLRRELGKLGIEWQGAAGDKAGGTITAQADYAGNADETAQRTSKATAEQSATFSQTRHVLPESTSLLGATQQSTWDKVAGFAGYETDHAEEVKQTQAAREQAIRGLDQYTEASRSTLDSYQGLNKPPNFDVTVASSATATVAHVATPAGHIGGVPTGLPASAGLPGGSVGLPGGATAGIPPQLPAGGLSGQLPGTPVGPSVPIQANPLLGRVPTSNIGLGIGLGLSTLTGLGIAGSVRPDRLVRGGGKGGTATGKAPEGGAKAVGKAGVAAGKSGISATLGAIDPDERPVGRAPGAASAATAAGNTRTGKVGTGTMLQPAASAKDEEDAEHVRKYGVDSDDVFGDERMVVQSVLGDDSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV6</accession>
    <name>A0A7W7WTV6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein subunit 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="31561" checksum="D5B2F993FB929905" modified="2021-06-02" version="1">MVAQVLVALGGAVVRVTGSGLGCPTWPECAPGSMFPVEHPELGQVHQWIEFGNRLLGVGVGVVAAIAFLVAWVGRPRRRRFLLLAATMPLGVLAQGVVGGFTVLMGLEWWTVALHFLPSPVLVWCAVLLAAAANEGDGPARWHAPRPLLVATAVVLGAVLVSGTLVTGAGPHAGDAGTPRLALPVSVLAQVHADLLFLFLGLVVALGFVARNRRYPLLVAAVLAQAVVGVVQYRIGVPIVLAALHVLGAMLTVAALAAVWTASRERGVLDVPQHEPGLGGVGGEDQEPVSVVAVDDRHPDAGPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTW8</accession>
    <name>A0A7W7WTW8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5796" checksum="CDB9F3B291E6997A" modified="2021-06-02" version="1">MSEPGRPFEAASRQDGERQRFLRRVCAVTQSRQISWTTLTDQSAKSKAKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU68</accession>
    <name>A0A7W7WU68_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetylserine/cysteine efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="141"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="31200" checksum="64EC24BCEDAA8989" modified="2021-06-02" version="1">MKPRDVVIAVFVAVLWGVNFVVIKAGLAELPPLLFSGLRFLVAAVPAVWLVRRPGVAWRWVVVVGLTLGVTKFGLVFLGMDAGMPAGLSSLVLQSQVIFTVVFAAVVLRERPRRVQLLGMAIAAAGIVVIAFDYGLTSPLSALLMVVGAAAAWGLANVATRYAKPPDALSFIVWVSAVAAGPLLVLSSVFEGPTRDLDALAHITWSGVGAVAFIAWVSTLLGFGLWGYLLSRYDASTVVPFALLVPVAGMFSGVVLLHETVTPVRIGAAVLVIAGMAATTVRRRARVPVEVPERVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUS4</accession>
    <name>A0A7W7WUS4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="359" mass="38028" checksum="FC7C5FD642046AC1" modified="2021-06-02" version="1">MSLELPARRPLPPEVRERMRRTVVRRGGARTPVAAAAAVVLLAAGVAIVAQSMQDHDGVSVGGPPTATSTSAAAAFRVGPPTAADLERCGVDRAEATVEVKGRRIVLGDSPCELTGTTRSVRKPDAPTPRLADGITLLWVSPTGVAIGTAPRDVVEVTASRGRVTLADDVWVTDPDIDTIGLTFIRQDGGHTAVDLDRNFHRGWSTTAESFARPGLSDERKVVERCVDRAVLDGAPWVGDLDRWTLATKGARVTIVRTADGTLLGCSDYPGAFPYGRVTPQDERPFRHLGAEKGTTPLRVGGMTREDVAALSYTDPSGNTRQAVVRDGVFEVDVDDSAGTPTVRATDKSGAVIYEGPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY6</accession>
    <name>A0A7W7WUY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13410" checksum="35DDAF532F33D5BE" modified="2021-06-02" version="1">MRNEPATPVAVTLPATSGSSAQARRVVVQAIEAWDLPGDLAEDAELVVTELVSNGVDHASGPLELTVTRTRTGIRVEVADGSSDLPVRRPVEVDSVRGRGLIIVESLSTSWGATPTARGKVVWAELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV53</accession>
    <name>A0A7W7WV53_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (DUF58 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="56"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="34240" checksum="32C3CC48A14BE72B" modified="2021-06-02" version="1">MTSPTEDDSPARPSWAPPNLHGGRMEAALRTLELDVRRRLDGLLQGNHLGLVPGPGTEPGEARPYQPGDDVRRMDWAVTARTTVAHIRETVADRELETWLAIDLSPSLDFGTAACEKRDLAVAATAAVVHLTRGGGNRVGALVSTGEKMVRIPARGGLAHARGLIRKVAETPRAPEGTRGSLAEVVEQLRRPPRRRGLVVVVSDFLGGTEWQRPLRALSARHDLIAVEVVDPRDIDLPEVGTVVLADPETGRQREIVASPLLRREFAAAAAEHRAGVAAGLRRAGAGHLVLRTDSDWIADTVRFVVARKRRWSGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV99</accession>
    <name>A0A7W7WV99_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="44" mass="4864" checksum="7EB319BA20DD16C1" modified="2021-06-02" version="1">MTHEALDPVIARLLCGELARRLRVEAGLDPGTASRDLREVMPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVG4</accession>
    <name>A0A7W7WVG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">4-azaleucine resistance transporter AzlC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="224" mass="22081" checksum="09445A1C14C50D1F" modified="2021-06-02" version="1">MRSTWRTPDRALVRDVAAIAAGAAVSGASFGAIAVASGAPVWLPVVMSLLVFAGGAQFMAVGIVAAGGGPVAAVVAGLVLNARHLPFGLAIGDVLGRGPVARLIGSHLLIDETVAFALAQRDPARARAAYWACGVAMFGAWNVAVVAGALAGQSIGDPGAFGLDAAFPAALLALVLPKLADRATRRAALLGAAIALAATPFLPAGVPVLLALGGLFVAARKGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM1</accession>
    <name>A0A7W7WVM1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dienoyl-CoA reductase-like NADH-dependent reductase (Old Yellow Enzyme family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="PTHR22893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38530" checksum="520967367EEB050D" modified="2021-06-02" version="1">MSRSEHAAPLFAPVDIGGLTVPNRVVMAPMTRASSPGGVPGPDVAEYYARRAAGGTGLIVTEGVVVDHAPNIVPDGIPRFHGEDALAGWRRVAEAVHRVGGLIFPQLWHLGAYDGPDAAPRGDVPAVGPSGLGVSGERVGEPMTEAEIAAAIGSFGRAASDARRIGFDGVELHGAHGFLIDQFLWDFTNRRTDAYGTRSRFAAEVVAEVRRVTAPDFPISLRLSQWKMGDYAARIAGTPEELADLLLPLVEAGVDVFHLSTRRFWLPEFAGSDLTLAGWTRKITGKPVVAVGSAGLAASDFESAFAGEGAAPEGVETIVAALERGDFDLIALGRALVSEPDWAAKVRTGRTAELKPFSPADLAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP3</accession>
    <name>A0A7W7WVP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18772" checksum="2DC57488E38F164C" modified="2021-06-02" version="1">MRIRPAEPHEYPLLQAIETASGEPFRAVGMTDIADDDPMPLEALRHAEVWVAADPDPMAWIAVVPLAGDAHVTQVSVHPDHARRRIGAALIDHVDEWARTEGLAALTLTTFRHVPWNAPYYRRLGFTEPAEPGPALVAVLAAESARGLTDRVCLRRPVGALRVTGRSPAESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ9</accession>
    <name>A0A7W7WVQ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031474376" evidence="6">
        <location>
            <begin position="24"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="138"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="624" mass="64027" checksum="8A140041A688260E" modified="2021-06-02" version="1">MALSVAAMVVAAAVVAVAPAASAVVEGTGPGAVDGSYLVVLKDDRTDPRALAAAYSGTVRTTYRHVVPGFSGEMTARDAGRLAADPRVALVRQNQRVRTTGTQTSPPSWGLDRVDQRDGGLDNSYSYSTTASSVTAYVIDTGIHTAHQDFGGRATWGTNTAGDGDDTDCNGHGTHVAGTIGGTSYGVAKQVRLVAVKVLDCAGSGTTETVLAGIDWVIAHHGNGPAVANLSLGGEADPLLDAGIRRLIADGVTTTVSAGNQGGDACLRSPARVAEAITVGATTEQDSRASYSNTGTCVDLFAPGDSITSAWKGWDQASDTISGTSMAAPHVAGAAALLLAVDPASTPAQIGAHLAADATPGKVDDAGTGSPNRLLVVNTGSRPGYPIVSNPGYRAQRTGTPMTFQMTATGGTAPYTWSATGLPTGVTINAGTGLVSGTPTQTIVDGQVAVTAKDKAGRATTARFRITVVPPGWTCPSGGQKLVNPGFESGSTGWWSSGYLIDRYTDVDAPRTGVYAAKVDAFTATGGSVTQDVTIPRECAWSTLTFYAKVTREGPEDQYDRLNVRIGDDVVTTVQGKGAPAGYRQFTVDLSAYAGKTVAIWFTGWGDTQNITSFVLDDIAVNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX2</accession>
    <name>A0A7W7WVX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="33944" checksum="8C052AA866E6FCF1" modified="2021-06-02" version="1">MSHRDAAPGDPFAVALREAIRRRGLGLDRIQQRLQARGTTISVAALSYWQSGRRRPERAASMVALRHLEEVLDVAPGSLTELLGAPRPRGRSRRGATTRPLAELWHESDRIEALLSRVHVDCDDELTRVTLHVIVELAADRGVRAVRTRQVLRAEVDGPDRWISIHDLTEPGWPIPRVLPVSGCSVGRIEADEETGMIAAELVFERPLSRGETVVVEHASVLDGPPYPRGNDSYGRVFRSPIRDYVIEIRFDPRALPVACHRFTTTPDDPDGGDRRRLPVNAEGAAHAVALNFGPGTFSVAWEWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW36</accession>
    <name>A0A7W7WW36_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty aldehyde + CoA + NADP(+) = a long-chain fatty acyl-CoA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.50"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LuxC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.50" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008670">
        <property type="entry name" value="CoA_reduct_LuxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05893">
        <property type="entry name" value="LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009414">
        <property type="entry name" value="LuxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="49400" checksum="CBCE4C275D31B479" modified="2021-06-02" version="1">MSVSWIPRWAEEIAQERFTLSAGDGAWPGGRPTDWAAIGAGLARAHRELRALPVARIVEAIDTVAERWAKPDFPPRRAAARVAVEVTGMSEATVDRALDAELGNLRAEHLYAALRRELGDPEVLDGFRAGTTAIGPRTVLGVFSGNVPGLPARSLVRALLVKSTVVAKIPAREPGFTAAFLRTLHEVEPVLADAVVATYWGRDDDATLDAVLDIADAVVAYGGDEACAAIRARVRPHQLYEEHGHKLSFGLVSEEYVRTVGLPEVARRIAADCSDFDQHACLSPQVYLVAAGQARAVAAQVAEAMRREADDCPPGRVDEDAAVVLAHRRVLARWRAASSDGEVWASPDGLRWTVVLDDALLPLSGAGNRVARIVAVPDLDAGVELMRPYARHFQNVGLGAVGDELHRVAFDLARLGVCRVTEPGAMTRPGMTWRHDGQPRIAGLVRWCDVERHAGFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ8</accession>
    <name>A0A7W7WWJ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="19750" checksum="8FDB4269E6E2E4C6" modified="2021-06-02" version="1">MDRRELLKTALGTGAGAVVACVMPDVGGTPGLPELISGPTAHYRRMESTVSSADLFPVVRAHLCPVTTLVRTRMDNHAGHAALDAGGTIEVVVPAAGYRDALPPEHHRDYDTLLARATTVTRLDHHASDPTAHMDASLRMLDQADALLAVWDGQPARGYGGTADVVRAAFTRDIPVTVVWPTGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV8</accession>
    <name>A0A7W7WWV8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SsgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006776">
        <property type="entry name" value="SsgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038658">
        <property type="entry name" value="SsgB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04686">
        <property type="entry name" value="SsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15529" checksum="3FB770A5D270F833" modified="2021-06-02" version="1">MRNDHVTLRSTAVFDLLAPRTPAVPVQVELRYDTKDPYAVVAAFRTGRAGWVEWVFARDLLADGLIADAGDGDVRIRPATDDPEVVVIELSSPSGHAMFEASAQELADFLDRTYDVVVPGNEHLWVDVDEALTHLISNDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY7</accession>
    <name>A0A7W7WWY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7307" checksum="C361FEAE1E3137A8" modified="2021-06-02" version="1">MPSARSRSRSGSRLAISTTSFRAFRVTAGQGGDVDTTCAIVGGVLGARTAPPDEWSRRCEELPDWVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX59</accession>
    <name>A0A7W7WX59_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OKR_DC_1_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046291">
        <property type="entry name" value="DUF6328"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19853">
        <property type="entry name" value="DUF6328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="3">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="31017" checksum="4C5837F0D2096DD8" modified="2021-06-02" version="1">MTAVEDLARHVDTLPRTRPVDLPEPGELELEQAMRPRDAFIAQAEHVRLRQSVGRVCAKTISPYPPGVPAALPGEVITEAVVDYPRTGHEAGMFLPDPTATWMRSAWLTGRCDGYLVRVNRAEETHQRRLARNFSELLQELRVAQGGVQILFGFLLSIAFTDRYARTDTYIRVTHLCTVLLAAGAVALLTAPAAWHRILFRQGRREDIIEVANRFAVAGLVFLALAMVGTLLLLAEITFGGWQSTAVGIGAAVVFGSLWFVMPLRERGQTDFEDEPEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX68</accession>
    <name>A0A7W7WX68_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9104" checksum="E03CE682864949E8" modified="2021-06-02" version="1">MKSHRRIHGELTLLGVAVAASTVWEILKTASIDPAPCRTTVTRADFLRSQAEAILAMDFIETVTLTGQRQYISPSSTTPVGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP1</accession>
    <name>A0A7W7WXP1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5321" checksum="3F74FA5975BC399F" modified="2021-06-02" version="1">MKWLTPKIPALSVAFDQDVGTGTGASHGSGEPRPLSGHAYEESLLGRDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXV6</accession>
    <name>A0A7W7WXV6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030741948" evidence="3">
        <location>
            <begin position="23"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="825" mass="87236" checksum="47B57666C5048627" modified="2021-06-02" version="1">MRRTVLLGLVFVLVGLSAPAAAEVVVPGAGSGEPVTATQTFDEHYNSGGPAEGSVTVSQTADLVRQRVKVSWSGLRPTAGSGVGASYPVVVMQCWGAPADVKRENCWAAGRGMEPATFNDAQPYDPVLFGDFGDIGLNLYTVMSFTARDGKRYSWDQVEVDPATGHPVAWPDGSVLPGPPPDLSQDTYNFVLPPTLIGETRADGTGSADIELLTADQMPSVGCSDVNACSLVVVPVGDPNCVPEDQILLDEWKAGCLPHATDYSSMRDASTWKTPTNWGRRFAFPLSFRKSPQVCTADDRSETTLTGSPYLGQLMASWRPKFCLDGNLFKLGYTSLGEGDARRQFTANLRERRADGVNAVLTSRPVAAVEGAPVGHAPVAVSGFSVSFVLDDADGREVLDLKLTPRLLLKMLTQSYTGAAPGIETHPAISGNPTWWGNDPELVEVNGGLRLRDINVAPSAYPVAVQGDMDLTWALTAYIASDAEALAFLGGTPDRWGMKINPKFAAQVLPYDRFELRDDWRVPANSPTYKEQLWFNLVANQVASVVGAAVALVQARPTATTNETIDNGKLVYKRPERQQTGNRALLAITDLGDSLVFGLPSAALRSRTGEFVVPTPESLTFGVATTVLDERTGVLTIDHTRTDGRAYPGTVLVYAAVPTRGLPAGEGERYAAFLEYAAGAGQQAGVGVGQLPVGYLPLPEPLREQARVVARAVREQKGDVPPAPQSVVSNPSGRGSAVAAAARPAVAPAAPVATTSVSAQPSVVTSSARPVTSAATRVESSSAGRWLLPGLLGLGVLAGVMAPLATVVATPGHPVRRFFGGLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF1</accession>
    <name>A0A7W7WYF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flagellar protein FliO/FliZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15254" checksum="8DE824609744CE09" modified="2021-06-02" version="1">MEALPRLLLGLVLILGLLWLIARVLRRPMRGRAVAAGLEVLARTQLTRGAGVAVVRVDRRALVLGVTDAGVSLLHEADADVFTAPTGTTHRTPLDLDELQARTEVQEQPAADGTTSKLNGSALSPATWRQAFDALKERSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF6</accession>
    <name>A0A7W7WYF6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="289"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="540" mass="55984" checksum="C127A788D10E88A1" modified="2021-06-02" version="1">MSEITGGEPTPRRGLGSVLVNRSLRTKILFAVALPALVAIALGVQEISTIESSSEATTRVGNNVMALDGMAQGTALMTNAEFGLLQAVAASDVATAQQQLGVYTKGIGIVRQMMSGGTPQMQADPLNVEMAGLITKFNDTVVGQIEPAIMAGDRATALSVYQTTIQPMIDRLQQIMEIMRTAQITGTQAEITSVDETRVSTRWNAILLVILGLTVAIGIALLIVRGITRSLRRLHDVLDSVAEGDLTRRAEITSSDEVGAMGEALNKATTSMGDTVRAISRGIASLETSAGRLSTSANEVAAGAEETSAQAGVVAAAAEQVARNVQTVATGSEEMGASIKEIARNANEAAGVASHAVTVAEATNGTVAKLGESSIEIGNVVKVITSIAEQTNLLALNATIEAARAGDAGKGFAVVANEVKDLARETAKATEDISRRVESIQHDTGNAVEAINEIGQIISRINDFQLVIASAVEEQTATTAEMNRSVGEASTGVGEIATNIAGVATASETTTTSVGETTRASEDLARLSTELRAQVGQFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG8</accession>
    <name>A0A7W7WYG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="38321" checksum="B23D6B280D56C973" modified="2021-06-02" version="1">MTVSTAFPVPGLGMSRGGPNVSTSLGRAGEALRWLDHVVRRSPWSSCWARMVLVREAWHAARLDGVPATLIEVLHHLLPRGHAVEVDAGLFPHVSAAREAIAHAGLPLVVVPEPLERVLVSTDRRRLPSALARAGLLSGPWLPFTGWLVDHPGTLHGDDPAMIALLADGIAETCHTEIALLDDLHHLHTRLLGCLPSPTRHHRTVLHDLAGRGMVNARDPATRHGRPSRSAHNALARLRDHGITTRHGTTDYGRSLYSPRRRRTPDREPAVTHTIRLRAVEFAKAMTLAGYRSDYALSQTMGLNRSTVTRVRTGHLNPGPAFIAGALIALAPMEFHDLFNVVARGEGGRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK5</accession>
    <name>A0A7W7WYK5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ORF">F4559_005914</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="639"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="818"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1187" mass="129268" checksum="AA3141AC37256479" modified="2021-06-02" version="1">MHQSGPLSGLLTAVLPDKALRALTESVGVPALELEGPPAARPLVAAALSLEAPVLAVTATGREADELTSVLRDLIGEDAVAHFPSWETLPHERLSPRADTVGARLEVLRRLARPDGDPLRVVVATVRSLIQPMAPGLGELVPVRLKTGADVDFETLPASLTAIAYTRVDMVEKRGEFAVRGGILDVFPPTAEHPLRVEFWGDEVSEIRPFSVADQRSLPQEVEEFVAPPCRELLLTASVRARAALLATEHEADAQLVEMLDKIAEGIPSEGMEALIPALCEDALQLLTDVVPDGTHVVLNDPEKIRARAHDLVRTGQEFLEASWMAAAGGGRAPIDLGASAYRNLDEVAEAARAAGRPWWTLSQLTSEGADVLRLELKHVEAYQGDIDRAFADLRAHTSSGGTAVLVVPGAGTAQRAAEQLKDADVPATLVESLDDAPRQGFVTVARGALEDGFALPGLALVVLTETDLTGGRGGTSTKDMRRMPSRRRNAVDPLALKAGDYVVHEQHGIGKYVEMVQRTVAGATREYLVLEYASSKRGQPGDRLFVPTDQLDEVSRYVGGELPTLNKLGGSDWKNTKAKARKAVKQIAAELVQLYAARQSAPGHAFAVDTPWQRELEDAFPFTETVDQMAAIDEVKADMERSVPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVVVLVPTTLLAQQHLNTFSERMRAFPVKVKGLSRFTDALEAQQTITGLADGDVDVVIGTHRLLQKGLRYKDLGLVIVDEEQRFGVEHKEHIKALRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERHPILTYVGGYDDKQVGAALRRELLRDGQVFYVHNRVSSIEKAARRIRDLVPEARVVTAHGQMNEDRLEKIIQGFWEREYDVLVCTTIVETGLDISNANTLIVERGDMLGLSQLHQLRGRVGRGRERGYAYFLYPPETPLSETAHDRLATIAQNTELGAGMAVAMKDLEIRGAGNILGAEQSGHIAGVGFDLYVRLVGEAVEAFRRHAGAEVDGEEELAEVRVDLPVDAHIPHDYVPGERLRLEAYRKIAAAVDEPSLQAVWDELKDRYGTPPLPVERLLAVARFRHTCRAHGVTEVAMQGANLRFAPLEPRDSQLVRLRRLFPKAVHKQAVKTVTVPRPTEGAAGGRMGAPVLRDQELLDWCARFLESLAGTPVSGVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK9</accession>
    <name>A0A7W7WYK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26695" checksum="A40CD636B9B00053" modified="2021-06-02" version="1">MAESPDAGIWSRRFLAALAAFGMGDRLKRGRPLVRGGQVMNLSISTSVVVALVTGAGPTPDRARVGVRRFADEDWRRVEHAFADRAVFTARLLAGDLPAEADEVFEGLGLSLFPRGARELSMDCTCDDWHMPCAHVAAACLTLADSFDADPFGVLAWRGRSREALLDRLRELRAPIPPVEKVPEPVADTDLVDFWVRPDTAPVPAAEDLGDVRPDALLDQLGPLAVRGRSVTAALRPLYEAFTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR5</accession>
    <name>A0A7W7WYR5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="65"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27466" checksum="C7AF63E7E959D652" modified="2021-06-02" version="1">MGMSGSKISRIETSDIGVYLDDLEKLLDFYRVTKAQRVFLLDLARNAEQRGLLRIHNPNLPEDWQTWTDFEDEASALLNYEPLLIPGLLQTPEYAKSIIVATGAGLSDAQVDALVASRMARQGLLNRTSPLRLRAIIDQQVFERPFGDPGAMDRQVRHLIALGERPNVEVRVLPTTAGLHSGLNGPFVVLEYDDDASLVLVENKISSLFIDEDEQIRLFESTWDELVRLAYDTEETVAFLRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW9</accession>
    <name>A0A7W7WYW9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FtsK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="392"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="410"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="920" mass="100759" checksum="5BEFB8D45B89B63E" modified="2021-06-02" version="1">MARRDDRKRRIEKSFGAFHGAVAAALGNAAREQRLIAEDRARDMVEVMVRGGGIDRALEDPAMAAVLGNPAFAPQVARALLDRVEAFREWSERGPDRLTALVDEVGTGAASRPPQAWLGTPGTADGSDGVPELWRIGTGVVRSAPEHQSFPVAVPLLDRAHLHIASAPEGRAAADALVENLLLRVLSHFAPGLVQVHVWDVNQLTGALPGLYPLTRAGLLTVHDPKRLHELLDELSDHIRRVHTGVLVQGHQSVGAAGGRRTEPWRIAVLFGNRKALKEEHQQQLQRVARNGLACGIQLFLVDIPVTVNSPIETVTIAADGSASCTMTGRHVTVTLDAPFDRTLVPRACAVIAEERENRRTRMSTFADLLPDRYWQEDSSARVAAPVGFDDGEPVPVVLGDTSPHALIGGPSGSGKTNFLYALLGSLAARYAPDELELYLLDFKEGVSFAQFAPGRKDPSWLPHARLVGVNVNTDREFGVALLRFLSDEMRRRADAAKRHEVTKLEQLREEDPEGRWPRIVAVIDEFQYLFAERDQVTSQATQLLEDVARRGRSQGIHLVLSSQDVSGIEGFWGKAAIFEQFTVRIALPKARRVLAEPQNDAAVELPRWHAVVNHESGVRPGNAIARVPDATTRGTFDLLQTELHQVRPPELTEPILFDGSKVPVLQDLPDFRALRPGASNPTVLLGQVIDVAGSAAQVRFPSAPGRNIAVIGSLAEDAAGVLRGAALSLAQQHGKAEARFTIACFADDAEPYAEKLHKQLDDLGYEAKKVPMGEFRDKFLVEKAGELQERLKGEGSALRPHYVIVYAVDGGHTFLEHKDDAKVSGVDRLRTVLKHGPENRTHVLGWWRGVQRLKNSLSPGVYDDIGAWVAFDVQGKELVPFGPEQVLSWSPRPRRGLFFDRFAPARPQVVIPFDTGEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ38</accession>
    <name>A0A7W7WZ38_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="3">3.1.1.61</ecNumber>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB</name>
        <name evidence="9" type="ORF">F4559_005747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="3"/>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="8">
        <location>
            <begin position="154"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3 5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="36744" checksum="744CA92EE0D5F22D" modified="2021-06-02" version="1">MISVLVVDDSVVIRRLVTDALGSDPRVRVVGTAPNGRVALQKIDQLKPDLVTLDVEMPVMDGVTAAREIRLRHPKLPIIMFSTLTSSGAEATLAALSAGASDYVTKPSNFGSVAESVRSVREELLPRIHALCERPRPMAAPPPVRRPAGGGPRPARGQTRVVVVASSTGGPTALRQVLRGLPARLSVPIVVVQHMPPVFTGMLAQRLDTENAVRVVEATDGMILEPGTVYIAPGDRHLEVAGAGKMVKTRLHDGPKENHCRPAADVLFRSAARVYGNSALAVVLTGMGRDGAEGCRALSAAGAQVLAQDQASSVVWGMPGAVVEAGLADAVVPLGGMADRILSALPVPEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE5</accession>
    <name>A0A7W7WZE5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="23283" checksum="86E605A70F7347AF" modified="2021-06-02" version="1">MDEQKLSELFREAATDVPPASFDLGGVRSASYRATARRRSAIAAGTSLVFVLLLGGGFVLSGGASHTSGTARQDASPGAAESTVPMIAQEPTVPNTGGTSPYSLPRDSSTQGDELPGSAGTADAGNASRGCVEVDRELAVALADELPVATPPAVPAVAQCPEGARGASYPVRDGADQGTVTVVFVPDGVAVLPTGASAPARGGTVYVFSTPAAGTGTGPFSSRLADIAVGVAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZG2</accession>
    <name>A0A7W7WZG2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper homeostasis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="22454" checksum="0CC2AFA378673FB4" modified="2021-06-02" version="1">MLEVIALHAADAEAAQAGGAHRLELVADMAADGLTPSVATLRDVLSATDLPVRVMLRDANGFAPGDLDALRRTTAELRAAGAREFVLGFLDDQGAIDVDTVRALVAELDGAAWTFHRALDNSTDPERSWDVVAGLGCDTVLAAGSPKGVADGLPVLEKLAARQEVVRLLVGGSLKPEHVAPLKAAGAMGFHVGSAVRPGGWDAPLSADAVRTWANLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZH3</accession>
    <name>A0A7W7WZH3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Streptogrisin C</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_Al_protease" evidence="7">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="35941" checksum="A2028DFD02187BCE" modified="2021-06-02" version="1">MTSSDTESYPAGLLQAAQRDLGLNAEQLSARLASDTKAGQVERAARAGLGDSFAGSWIDASTGRLTVGVTDARRTGVARAFGADVKVVTYSARQLAGTKSSLDRTSAPVSITGWHVDDASNTVVVEVNKLTRDAAADKFIAGAKTLSPAVRVVEVTESPTTLADTRGGDAYYIGSGSRCSVGFAVTGGFVTAGHCGKSGNTTTGVNRQSQGTFRGSSFPGNDYAWVATNSSWTSKPWVNRYNGSNVTVKDATEAATGAQICRSGSTTQWRCGSIQARNATVNYPQGSVQGLIRTSACAEPGDSGGSAVAGTGFGSAQGMTSGGSGNCSSGGTTYFQPVGEALSAYRLTLTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X048</accession>
    <name>A0A7W7X048_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19978" checksum="20A6635731B25470" modified="2021-06-02" version="1">MDESRRNDTYYLAAAIVDPKDLTVLRKRLGGLLLPGQYELHFKKEMPSRRKEILSRLVEWQAKAVIHQASCGRDVEAARQACVARLAEDLIDVNCVRLVLDSREERDVFDMRTIRTTLGKYPRASGFIYEHMSSTRESLLWIADAVAWSHGAGGDWARRVRPVVEEVVWVDIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXB9</accession>
    <name>A0A7W7SXB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="26518" checksum="90B649B3F949DA93" modified="2021-06-02" version="1">MAVPDSVRRGGSLLLRTLAVGGVATVAWLLGHGVAGASEEDGATTRETVLQVMEQQHAANVTLLTGLVENKAPAQSTSTAGTASTTKDDRQSEADYSGSTTSTTPTTLTGSVSNTVPTPTPAAPPAPVVEQHEAPPPPPETAPVVEAPPTPPGYAWTPPTETEPLPEAAPEPSPVQVVDVTWHKPEAPAPAPAPKQSPGTPTCGTSAGAQDTSNSHRAGVSAVVANQFPLRPVPSWRVERREDWPSAGRTQGLPSASPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXK6</accession>
    <name>A0A7W7SXK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heptaprenyl diphosphate synthase</fullName>
            <ecNumber evidence="3">2.5.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.30" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036422">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35185" checksum="C60608348FAECCBD" modified="2021-06-02" version="1">MTSSEQAGAGFRFADPVLADVVQGGLTEVEELLRKVVQSEFHPVMETALHLVEAGGKRIRPLFTILSAQFGSTWDRESVVKAAAVVELTHLATLYHDDVMDEATMRRGAASANAKWDNSIAILTGDYLFAHASALVADLGTAAARIIAETFSELVTGQMRETVGPRPGEDPVEHYLTTIAEKTGSLIATAARFGAMFSDASPAQVAALQAYGDVIGAAFQISDDVIDIASPSSESGKTPGTDLREGVKTLPMLYALADEPSSRLASLLAGPIASDELVVEALELLRSSSGLVRARATLDEYAARARAHLDALPAGTARDALASVSDYVVTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH3</accession>
    <name>A0A7W7SYH3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10782" checksum="38C596EA5211804E" modified="2021-06-02" version="1">MAQRKRSDPTEDRWNEAMSVERLSQAHDIVGRLMPRPDAASEVWMDFYRRSVRVYERVAEVDRGHHHEALYWAGRERVKAELLASSDRNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK7</accession>
    <name>A0A7W7SYK7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hutU</name>
        <name evidence="13" type="ORF">F4559_000609</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="131"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="341"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="546" mass="59128" checksum="A9CF51B8D5848067" modified="2021-06-02" version="1">MVKAARGTELTARSWQTEAALRMFHNNLDPDVAERPDDLVVYGGTGKAARDWPSFDAISRELARLADDETLLVQSGRPVGVMRTHEWAPRVLIANSNLVPDWANWPEFRRLESAGLTMYGQMTAGSWIYIGTQGILQGTYETFAAVANKRFGGTLRGTLTVTAGLGGMGGAQPLAVTMNEGVALCIEVDPDRARRRVETRYLDEVADDLDDAIARVLKAKQDGRALSVGVIGNAAEILPELLRREVPVDVVTDQTSAHDPLAYLPKGVALEDWADYAAKKPDEFTDRSRESMADHVEAMVGFQDRGAEVFDYGNSIRGEAKLAGYVRAFDFPGFVPAYIRPLFCAGKGPFRWAALSGDPADIAKTDRAILELFPENEQLARWIRLAGERVEFQGLPARICWLGYGERHLAGLKFNEMVASGELSAPIVIGRDHLDCGSVASPYRETEGMIDGSDAIADWPLLNALVNTASGATWVSLHHGGGVGIGRSIHAGQVTVADGTPLAAQKIERVLTNDPAMGVIRHVDAGYPEAVEVAAERNVPIPMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP8</accession>
    <name>A0A7W7SYP8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6662" checksum="5E588991FCB7E7AF" modified="2021-06-02" version="1">MAPDLPDSIFKTSSYTENAGTCVEVARLSGYVAVRDTKYRSGGHISVPPRAFQAFLNGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR5</accession>
    <name>A0A7W7SYR5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPPG:FO 2-phospho-L-lactate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="33869" checksum="ED30FB6513AE8661" modified="2021-06-02" version="1">MKVVVLVGGVGGARFLEGLKALLGGREHEITAVVNTGDDVWMHGLRITPDLDSCMYTLGGGSDVGRGWGRAGETWTVKEELAAYGAEPSWFGLGDRDIATHLVRTRMLRAGYPLSEVVEALCHRWQPGVRLLPMSDDRVETHVVVDLDGESKAIHFQEWWVRYRAEPKAKSFVSVGAETAKPAPGVEEALLTADAVLIAPSNPVVSVGTILNVPGVRAALRKTEAGVVGLSPIVGGKPLRGMADACLEAIGVETSAEAVGRHYGSRRTTGTGILDGWLVHTGDRSDVPGVAVRAVPLLMSDVDATAAMARAALELAGVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS4</accession>
    <name>A0A7W7SYS4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="400" mass="43170" checksum="B86C7D3C475B4E38" modified="2021-06-02" version="1">MTSVTIVGLDFHPDSHGVAPYSTGLARGLAARGHAVRVVTGFPYYPAWRLPAEYRWLRHGLARRTREHGVDVTRLWHHVPRRPTAIGRFVHEASFAAHALVRLLCTRPRPDVVVGVSPSLLSSAAARCYADRVGVPLAVVVQDLCGRGTRAAGFERSLLARAAGVSVAHDSVRSYLEHAYRLDPVRLTVIRDWAHGASCRPDVDRHEARRALGWPVDGFVALHAGNMGVRQDLVNVVEAARIAGIRREPVHFVLMGDGAARPEVVARARGLPRVSVVAPVAGDLLPTALGAADVLIVNERPGPPGIRLPRKLTAYFRAGRPVVAAAHRDSTTATEVTAARAGCVVEPGDAVALLNTVLDLARDRAYAESLAAAGLDHARRTLDRDRALDAYEDWLCGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA3</accession>
    <name>A0A7W7SZA3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Muconolactone delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15933" checksum="1AF7CB67E1F1AB32" modified="2021-06-02" version="1">MLFYCQMRWNHEGRISLDELWEIEEEETRHAEETLNSGYCIGLWKVAGQKRVIAVVDAESAEELDRSVFRLPMREYLEFEVIWPLRDYLGFAEDVQNRYRPTDAETPAATPSGDPVGIPTGNRPVNLLGNNGFGVNGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA8</accession>
    <name>A0A7W7SZA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16530" checksum="447178B982E43AAC" modified="2021-06-02" version="1">MTYFLAERRALAHRPLVKIAYTVPEAATALGKPDHTIRRLIARGVIRSRNTGSEYLIAGGTLLDLVEGTLPGIVDHRDVVHADDYYLTADLLALLPLSEEQIRGLVHPGNARFRKGPLVPTHRSPRLIVPGSSLLEYLNGEDAPIRHSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZD1</accession>
    <name>A0A7W7SZD1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative flippase GtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20799" checksum="C2ADF73E666F4BF2" modified="2021-06-02" version="1">MSVVENVVRRLPEPLRSLALKHRELLKFAVVGGICFVIDTVIFFVLKTTVLADKPVTAKIIATLVATIVSYVLNREWSFKTRGGREKHHEAALFFLVNGIGIVLNSVPLWVSRYLLHLQEPHISRWGEEIADFVSAQIVGTLVAMVFRWYGYKKWVFPQADARPRKVARSYDEPQDDEALGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE5</accession>
    <name>A0A7W7SZE5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="14576" checksum="9054770668D3E063" modified="2021-06-02" version="1">MSDDRFDDLYRVELQSGASLEAFTVVVRDACREFAFLLSYQADQVQVSLATFQFRRYDEEGRQISDPFGRLTAKARAKIVAWALRQSADAVLHAGRMAVKSYALYFKYFKRGMTPEQKRKKTTWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZH4</accession>
    <name>A0A7W7SZH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032584">
        <property type="entry name" value="DUF4913"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16259">
        <property type="entry name" value="DUF4913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19721" checksum="C682B58514C120A2" modified="2021-06-02" version="1">MTSPEHLRADLDHLTGIVEHLVVVVERFRSHPPGSWSWPHLDASRAADLWSEVADFVDHLNTREELGPGARIPPCWFLHGRAVEDLTALLAAWRYAYQATTPTAELIDYRNRHLWPTLDRLTDLNTPLRRCADKGRHTPWHEPDDHFLAADGCAFDRATELARHAAADVADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZQ0</accession>
    <name>A0A7W7SZQ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="25821" checksum="DAD9F864C39AFD0A" modified="2021-06-02" version="1">MAARLYALPPAAFVAARTSFARAAKGVLAKEITALRKPSLAAWALNSLSRTDTLRPLSELAVALHSAQSAGRGDELRVLDVERRRLISDLTREATASAALSGYPLGPSAVAQVRATLSAALATTELLERLCAGRLVKAEEASGFGPLPVVPAPSSDSATSTSPSTLAATLTAARHALADATSALTDASHTRAEAERVHAEAERALRAARTAEAEAYSRVVTARDHVTQTEALLSGFSSDPHHAGNTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZQ2</accession>
    <name>A0A7W7SZQ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35593" checksum="42804E9D680E750E" modified="2021-06-02" version="1">MTTLSPNGAVRRATMNDVARLAGVSIKTVSRVVNDEVGVHPATAERVLAAIDQLGFRRNLSARNLRRGSSTGAVGLVLEDVANPFYSGVTRAVEETSRLRGRQVITGSSDEDPNRERELALDFCSRRVDGLLIVPAGSQHAYLVPEMRAGTPVVFLDRPAGDIAADTVLVDNVGGTAAAVAHLVAHGHRKIAFLGDAPDIFTAAERLRGYREGCVRAGIGPHEDLVVMGPHDAASVAAALRSLADRATAVVTGNNRITVHAVRALAGWTRRPALVGFDDFELADLLSPPVTVIAHDASALGRAAADLLYARLDGDTGPPKRVVLPVRLVARGSGETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZQ3</accession>
    <name>A0A7W7SZQ3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6504" checksum="6006947F808A6A39" modified="2021-06-02" version="1">MRPDFSTATFKTSTRTDGNGTCVEVARVPGFAAVRDTKHRSVGHISFSDKAFGAFLKGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZR4</accession>
    <name>A0A7W7SZR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="25773" checksum="892898EB08D4FF79" modified="2021-06-02" version="1">MRFENKTALVTGGTSGIGLAVARRLLDEGAHVVVTGRDAARLDTAVAGLGPRASGVRGDASSLTDLDVVVDAIRDRHGRLDVVFANAGVAGFAAVEDVTEQEFDRIVDTNFKGVYFTVRKTLPLLGDHAAIVINASWTLHRGLPGASVYAATKAAVHNLARTLVADLAPRGIRVNSVSPGYIRTPMFDEHVPDGTHAAILGAVPAGRFGTPEDVAGVVAFLASADAAYVDGQDVVVDGGLVATHSSTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T023</accession>
    <name>A0A7W7T023_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20325" checksum="1D396C366838B9A3" modified="2021-06-02" version="1">MRKRRTRDDWTEVALKALAEGGVAAVAVEPLAARLGATKGSAYWHFPNRDALLEATLERWDREHTQAVIAVVEKQADPFERLRLLFGVVMQNVEDSAVELAMLAAADDPSVAPVLGRVTARRISYLVDLFIALGFDADVARLRAQLAYSAYLGQMQLLVKVPDVVVEQRALLDETLRLLTTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T057</accession>
    <name>A0A7W7T057_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001493</name>
        <name evidence="3" type="ORF">F4559_003918</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="20011" checksum="AFAED1843EDD7A03" modified="2021-06-02" version="1">MARFDLTDAEWALIEPHVPVAATGPLPRRVRERFNGILWRFRTGSGWRDVPERYGPWSTVYSRFNAWAKAGVFQVLMDALIAEAASRGQVGLELVGVDSTIVRAHHESAGLAVAGETLDALEQALTEEKGAPLPTQRRVLRVMRRRPHRTPPTRARLPVGTVPPSGGAGRRGLRRPGSAGPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T060</accession>
    <name>A0A7W7T060_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14506" checksum="94EEEEF255CD811F" modified="2021-06-02" version="1">MSQGNSDVSVEVTPDGIVAHACPVVEVLDRVAGKWSILVLVAAAHGPIRFTELERAVEGISRRMLTLTLRTLERDGLLTRTVHATVPPKVEYAHTPMARELHASLLQLTDWAHRHRTVIQAARAAYDGRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E5</accession>
    <name>A0A7W7T0E5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="43347" checksum="C8825AD19CBF3662" modified="2021-06-02" version="1">MARVGKDGAPPDAASVEGIGYDGAPAPGVDDHAGPSSALDIMRRWSADDLLVTLGHLKTHRKDGKSAPHKPLALVWAIARLGTGHGRLFRWDEFRAGVGAVLGEFGHGQVTPQYPFWHLRSAERLWETHGLDEEPTARDGATTAGFTAEAAAVLRDPITRDRALATLATTYLGDVDGNALRRFVGLATLPGAERVLRDLEGTGVGPDADAALVQYGLDRLRADGSVSVDDLGDAVTAVLLTRPGTRLEDGRVVVRPLGRPTRRDYAVFDGKALATYRKEQGELRRLLIGDGPTAECALCRRVFPVDLLVAAHVKKRAECTDDERGDLENVAMLACSLGCDRLYELGYLAVDADGTVLVHGTDGFLDGRAGVVAGVDPERSGPYFQWHREHVFRGLSEGLATIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E3</accession>
    <name>A0A7W7T1E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase alpha subunit</fullName>
            <ecNumber evidence="6">1.13.11.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.3" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019439">
        <property type="term" value="P:aromatic compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03463">
        <property type="entry name" value="3_4-PCD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012786">
        <property type="entry name" value="Protocat_dOase_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02423">
        <property type="entry name" value="protocat_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="5">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19998" checksum="9FEDCE19C197BF77" modified="2021-06-02" version="1">MTELRTTPAQTVGPFFAIGLPWDDGPFVVDEGTPGAFTVAGRVLDGVGDPVPDALVEVWQADPDGRFDHPDDPRGAVSRPGFRGFGRSATDDDGRWSVRTVKPGPLPTPDGRTEAPHLNLSVLCRGVLVRLVTRVYFPDEDNSADPVLESLADAERATLVAAAVDAGYRFDIHLQGERETVFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S8</accession>
    <name>A0A7W7T1S8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA ATPase forming ring-shaped complexes</fullName>
            <shortName evidence="2">ARC</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arc</name>
        <name evidence="6" type="ORF">F4559_002332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer. Assembles into a hexameric ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02112">
        <property type="entry name" value="ARC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041626">
        <property type="entry name" value="Prot_ATP_ID_OB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022482">
        <property type="entry name" value="Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17758">
        <property type="entry name" value="Prot_ATP_OB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03689">
        <property type="entry name" value="pup_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="276"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="287"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="600" mass="66333" checksum="E0B58E9DAF8E92AD" modified="2021-06-02" version="1">MPHGHPGSRPDEGGELNTGNNPGELTAQIRFLEDEIALLRRKLTESPRHVRLLEQRLAEATERVSQLTERNTKLIDTLREARSQLLALREEVDRLAQPPSGYGVFLAKFEDGTVDVFTSGRRMRVSVSPAVEATTLVRGQSVRLNEALTVVEGGDFERTGEVCTLREVLDSGAADGSSVARALVVGHADEERVVWLAQPLLDSPLKAGDSLLVDSKAGFAYERVPKAEVEDLLLEEVPDVAYEDIGGLGRQIEQIRDAVELPFLHADLFREYKLRPPKGVLLYGPPGCGKTLIAKAVANSLAKQVARARGDDHHEAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGSGVSSDVETTIVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEGAKDIFNKYLTADLPLHADDLAEFGGDPQACVQGLVQHTVERMYEETDENRFLEVTYANGDKEVLYFRDFNSGAMIQNIVDRAKKAAIKSLLDTKQPGLSVRHLLDAIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKNQESGRAIDTATNTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T251</accession>
    <name>A0A7W7T251_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Streptomycin 6-kinase</fullName>
            <ecNumber evidence="1">2.7.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.72" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050300">
        <property type="term" value="F:aminoglycoside 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="32774" checksum="FE24E2396C237F4C" modified="2021-06-02" version="1">MGFVVPRAVVARCRDAAEAAWVEALPVLAEELFGRWRVAVDGPARYGMAGVVVPVVGADGVPAAVKFQRPSPESADVVAGLRAWRGEGIVRLLDHDPDSGTLLLERLDADRPLSVVSEDESLEVLVGLSRRLWAVRAPEGVRRLEDIARDMIAQVPGAVPGLRDPLERRLVEYCAARVAELVDDAGDRLLHWDLHCDNVLAAEREPWAAIDPEPLAGDPGFDLMPMLDGRWDEVVAGGAAVAVVRRRFDVLTEGLDRERAAGWTCGRLLQNALWEVEDGRGALAPEQRVVADALISAAATSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D1</accession>
    <name>A0A7W7T2D1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">F4559_001439</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08971">
        <property type="entry name" value="AcNei2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044090">
        <property type="entry name" value="Nei2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="16">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="15">
        <location>
            <begin position="223"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4964080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="29643" checksum="C00C4D1E3FBE5607" modified="2021-06-02" version="1">MPEGDTVFLAGHRLNEALAGRTLVRGELRHPRWATADLGGREVSEVRSVGKHLFTRFSDGLSLHSHFRMDGAWHLYRPGERWKRPVHQVRALLEIVDRVVVGFALHDLELLPTAHEDRIVGHLGPDLLAEGWSDAHETEAVARLVTEPDRELGLALLDQRVVAGIGNLYKAEVCFLLGVSPWSAVRTVDARDAVRLSRKLLLANAWHPEQTTTGLSVRGRQHWVFERQGRPCLRCGTRVRVSGQGAGVRERPAYWCPRCQPGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D4</accession>
    <name>A0A7W7T2D4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="79"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33924" checksum="B58A2ECE26447842" modified="2021-06-02" version="1">MPLHPEAQAVIEATAAQGGLIPLDAGSAADVRARFAASWRPSLRRQEVASAVDRAVPGPAGEIPVRVYTPEGEGPFPALVWYHGGGWVLGSLDENDATCRALANAVGMVVVSVDYRLAPEHRFPAAVDDAHAAYLWVVESGDAIGVDTSRVAVGGESAGANLAAVVSLRTRDLDEPRPVFQLLASPVIAPPSERQSYVDYAVDHFLDRESMEWFFRQYPAKPEDLVHPHLAPLEAEHHRDLPAALVFTAEFDPLRDEGEEYAHRLLDSGVPVQLLRYEGQIHGFFALLVDQLGVSADAHARAASALRAAFHKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F0</accession>
    <name>A0A7W7T2F0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease I</fullName>
            <ecNumber evidence="3">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19770" checksum="7FBEF5FCC826C7E8" modified="2021-06-02" version="1">MAGELNGRRIAILAADGVERVELEQPRQALDDAGAHTVVVSIADGEIQARDHDLEDAGTFAVDRLVGEVSVDDYEALLLPGGTVNPDKLRMEPAAVRFVRDFVRSGKPVASICHGPWNFVEADVARGRRLTSWPSVRTDLRNAGAEVVDEPVVTDGNITTSRSPDDLPAFCERIVREFAKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3B2</accession>
    <name>A0A7W7T3B2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Outer membrane protein OmpA-like peptidoglycan-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="283"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="41874" checksum="AE89C624CAF45F34" modified="2021-06-02" version="1">MSNRYGQVRGRAKPRGSRADRPDRTGLIVKGAVAVVVLLVALGIVLGVEKEPPESHVVWLAEKSTRAPGGIPDKIRERVRELGAKGGGELVAYAIGERAERAGEMPLAVMHDGDPEPDDARRTKVLDTRLDDLATRMADVAVSRSGFSLYAALRTAADAAAERDGRVEVWFSTTLFTGSVPPLAVGTLTAADPGAAADQLVGAELSGLDLGRVDLHPVLLDPIGPDQQPLGPVEESWRTAFVEQLGTGLRATVADPLHDSTSDPAWSKASQVSAVPLFAPPPTKPAQPGRVDNLAFHPDSPDLLDAGVTKAQLGSIVEKIATGSYDIRITGYCARFGDPAGARDLSKRRADVIAGLLADSGVARASITTDGAGFDRRGDASAPPDSPAQRVVVIDLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3F9</accession>
    <name>A0A7W7T3F9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="41"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27131" checksum="5FD26D0874D455CB" modified="2021-06-02" version="1">MERSEIFDIAHLRHPIAAPVAPRRLRELVGWLRPSDGARAVDLGCGEGEWLQELLLAHPGMTGVGIDHMLPASAAARAGERGLGDRVRWIETDAATWADGGFDVVVCVGASHAFGRLEDTLVAVRRHLRPGGQALVGDSIWEVPPSASALAALELPADAYPDLAGFVRATREHGFEPSYGHVSTVAEWDDYQFSWSGSLVDWAVREASTTEDRDQALAVAREHREAWLSGARRELGFATFVLHDVAGARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J8</accession>
    <name>A0A7W7T3J8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30746" checksum="2AB086DD7D315761" modified="2021-06-02" version="1">MITTRTGDLGGFLRSRRERLTPERAGLHPGTTHRRVPGLRREELADLAGVSVGYYTRLEQGIGTGASTAVVDALAAALRLDPAEHDHLRTLAAPRPPTRPRTRRSRLRPAIRDLLAALPGTPAIVIDHRADVLAWNPLGHALLAGHLDPAAPDAPQRPNIARMLFLDPHHRALYRDWHAKAQTTVAALHQAAARHPADPGLDRIVGRLAVDSPDFARLWARRPIRTCAHAVRELDHPVVGRLTLANETVTLPDDDQHLGLFHARPGTPDADALTLLARSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N4</accession>
    <name>A0A7W7T3N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="22377" checksum="0C8639EEABB05DCD" modified="2021-06-02" version="1">MPKVIDHDERREHIVDVTWDLIVRGGLEAATMREIAAAAGFANGALKRYFPSKDALVEATFDRALSMMQRHIAATTNSHSGLAALRAICYGSMPMDTKRVTAGRVLMAFWEMSLSNKRLHDRYLEHLKTWRSYLHEHIRAGREQGEIHTAIPDDQLVDEIVLINAGANIMSLVGPRFSTKKLQRRHLDSFFDRLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N5</accession>
    <name>A0A7W7T3N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="38606" checksum="A243F4A503D60631" modified="2021-06-02" version="1">MPPAVYVLSLGIFAMTTSEFMVSGMMPSLAAGFGVSVAAVGYLVSAYAAGMVVGGPLLTVALLKVPRKNALLLLTVIFLVGTVLGAVATDYAVMAVARVITGIASSAFFGVALALCADLVGPSLRGRASSVVLGGLMVGTVLGLPAATLLDQHLGWRAAFWMVAALTLVAGSAIAKIVPDLPKAAEIGLRAELGAFRNGRLWAAYAVSGLTIGSVFAAFSYFTPIYLDVSGFAAGVVPLLLAVYGVATVVGTAVVGRLADRHATRTMAVGLAAIAVSLALFGLFAGDKAVAVLCTVVLGLVGVSLNPAMVTRVMRAANDRPLVNTVHTAVINVGIMVGPWVGGLAITAGFGLTAPLWVGVGLAVLGLSAVLFRTSSAVRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V4</accession>
    <name>A0A7W7T3V4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="17"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="27759" checksum="606796B485C57E00" modified="2021-06-02" version="1">MTTVPGSVSAAFVDSATMLRRQLRHLVRYPTLVLTAAGVPVVFLLLFVHVLGGALGRGLDGPGTYVDYVVPGIILMTVATAAQGTAIAVALDMTEGIVARFRTMAIARISVLTGHVLGSLIQTMFSIAVVIGVALLVGFEPTADPGDWLAAAGILVMITFAVTWLCVALAMVAKTVATASNLPMPLMLLPMIGSGLVPTDSMPAWLRWFADHQPFTPFIETLRGLLTGTPIGDSALLSTGWCAVITVGGCLWARKLYDREPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Y1</accession>
    <name>A0A7W7T3Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor ChrR (Cupin superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_7" evidence="1">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12126" checksum="4E703C4F81FD66CF" modified="2021-06-02" version="1">MNQEILAQEGYTSVTVADSPVRELFPGVRLRPLWTGSDGAHANVLEMDPGTSWPHRDVHSPGPEEVYVVSGTFNDGARDYPAGTFLHAPAESWHIPQTTTGCTLFVFYPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T476</accession>
    <name>A0A7W7T476_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031121951" evidence="1">
        <location>
            <begin position="28"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="42"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="37388" checksum="02D5C8C30B097DFB" modified="2021-06-02" version="1">MRPHRFVAGIAAVMMLAACGSGNEAGSSDPNRKLNLAFVYATSTQNPFQEMAFGAKAASDDAGNVNLTLSAPSGINGAQQVTMFQSAVRNATDGVALETLTPDLFVRPLNQATDSKIPVVAVDTAPPAGTKVDLFIGNSNTDLGKALGEEFIKKVPEDATGEVVLGNDIPGLGVLEDRLKGVQEVIKAKRPKLTIKGPFDSGSEPTTNFEKWNDIVKANPNALAYLGVGAQDAVSLALIQKNTGRKFLAGSCDPDSSALQAVKDGYVFALASPEHWLKGYVALRLLADHARGKELPKGWWNTGQLVITSENVDQIIARQQNEDTRKSAFKTEVDKQLADPSKYIRPIGEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C8</accession>
    <name>A0A7W7T4C8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding beta-propeller fold protein YncE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="38950" checksum="7D2B8C3CAA313880" modified="2021-06-02" version="1">MIGVVAALGLLAACAADISGDDEVEITMVPLGRLSPGHLVVAPDGRSSYFASATFSEEDKRVQVLDNARREIVATYTFDTDPDDTWVRGMALSGDGRWLHVITSHRLVVLDTATGATAATVVPPDTVGLGALAVARDGRHVYLFDDQSALLGLPGRIFVVDVGTATVVGQTALKRDLANGALVSPDGTRLYATTSGWSKNRTESQVALETYDITTTTPRFVSDIGLLPPNQGVYHPALNPVLSDDGQRIYAVGSYRDLLVVDPVHERLVATIPVDNGGEHVRAVAVRHDGSAVYVARDQRTAADGPVVAVVDTATARIVDTLVGFEDDYIPALAVAPGDDTLYTASVTDPGTDTRYGAAQIVDLDDQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F1</accession>
    <name>A0A7W7T4F1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13606" checksum="4CE0B9723B68F11B" modified="2021-06-02" version="1">MSRKPPVVVPSQTRNGSATAGSTRPAPEVLEVLCSAVDGALAMLGADAPPGPVLESMLTAFTERVAPVRERIADSPDGSLRIVQCYLGNAFAHAVEGDVAATRSALIAARVALARFFDDEPDTERRWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q2</accession>
    <name>A0A7W7T4Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="58" mass="6539" checksum="8644989B3021F63E" modified="2021-06-02" version="1">MIDESKAVVSVLGDDERAELDWLRAENAFLRAQCDALVSIAGGYARDMEVLLRRTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T510</accession>
    <name>A0A7W7T510_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7891" checksum="E668593053F55C73" modified="2021-06-02" version="1">MTQYDLAARLRAVSGSGITREEVSRWERGKRIPGPYWRGWLGKVLDISEYKFERAAAIARALRRTDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T528</accession>
    <name>A0A7W7T528_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="913" mass="97945" checksum="69F8B1A40F336584" modified="2021-06-02" version="1">MGAVRFRLLGEVRTSTADGFSPIRHARVRCVLAALLVDANRVVDVDVLADRVWGERLPKRPRDAVYSYVSRLRQALVDVPGAGLGKRSGGYVLDVDPRAVDLHRFRELVARGGDDRDRAASLGSALDLVVGTPLTGIDSPWATSVREAVESEVFAARLDGHEVGLRLGQHVQAVTPVTALAAEHPLDERVARLALLALAGSGLYAEALAHYEALRQRLADELGVDPNPELREIHRRVLAEDRASAASHPVPRQLPAAPRWFTGRVDESAALDGLAERPGTAVVSGSGGIGKTTLALRWAHRHAERFPDGLLSVNLRGFDPSGSPVPPTTALLGFLEALGVERDAVPADPDARAALFRSLTTGRRVLVVLDNAADADQVTPLLPGSGCVTLVTSRHRLPALVAAHGAIPVRLEALPAADARVLLAERVGAARVAAEPAAVDDLVGHCGGLPLALGIVAGRAQEHPTFPLAAFAAQLHDVTTRLSELDDDPVVGVRTVLSWSTGALDEEQARMFALLGTTPGPDCSVVAAACLADLPLSRAMVVLRALERVSLTQEHRAGRYRMDDLVRLHAAEQDLQPRERDDAVRRVVDLHTHTAAAATARVWPFRRASPLGPVTPGPHTWEPEDPDSAMAWFHDERACLAATVRAAADLGLHGRVWQLARHLTPLYDRAGFLQDVVDAWRLAVPASHALGRDDLLADALLALGYAQGQLGRLDDGLDHLHRALALARRVGDEMVEAIAENSLSILVEWSGDLAGAMRHAKRSHELLSRQGNEVFEAQSLSQLGWLAARLGDHGIALDACRTAVAVFRSRGDRDSQAISTSALGYVAHATGRLDDARALYQEACDLLRDVGNVRREAKAAEMFAEVLVEIGDHAAAHAAWARARGLFLAQHRFADVERVEARLGTLDGDRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B8</accession>
    <name>A0A7W7T5B8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="6">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20367" checksum="18AA08077527772E" modified="2021-06-02" version="1">MSDSDHALAAFGFELGVLKRMRRAGWWHAGVRDPESVAEHTARVAQLATLIAAEEGADPARAALLALWHDTQETRTGDLPHTAGDYLAKPDPQAITADQTARLPQRSRDTVRDAVAEFEAKDTVEARCARDADKLEMLLQAVEYRDTGVRRVDGWIDSALKGLTTDTARRIAEAAVALSPLAWRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C0</accession>
    <name>A0A7W7T5C0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MinD-like ATPase involved in chromosome partitioning or flagellar assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="30645" checksum="EAA6ACBEA93B0527" modified="2021-06-02" version="1">MLISILSLKGSPGATTLAVALAARWPAPARALVVEADPSGGDLGLRFSLSSTPGLVSLAAAARRGGDADLVWRHTQQLPGGLPVISAPPDADQARAALAALAPDPTSGLGVLRAAANQPGTVVIADCGRVDPGSPALPIVRASDAIVLLSRAHADDLAHLPRRLPTVGRWSPNPVLLLVGEGYSTAEVARELGVPPLGRVPDDPNGAAVLCGRPNKLRWGRSGPAHSALGRFAHRVATELATRERTPASRAQPRPPEPVTQVPLLRSVPGVPPGAVSSNGIRVAPSPAADHRDQQGGQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T1</accession>
    <name>A0A7W7T5T1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14789" checksum="1C8F327544B724F9" modified="2021-06-02" version="1">MITRRRPPWWVLAYALVLALIGMHHLATDHRQDVRAMTHAGSTAAFTAHSGTSAMPPVAEVAPRGEPESHHSPAAPADHLGLHLCLAILAALLVLLALGRRAPAAHSPATRTTERSTTPIVRRSVSPLFERLCVLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T613</accession>
    <name>A0A7W7T613_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031548586" evidence="1">
        <location>
            <begin position="25"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="699" mass="68881" checksum="ACF23FC71BA31862" modified="2021-06-02" version="1">MGMARRSCVLAVGVLLAGTVQAHAVDGNLPGGTGIGVTVTSPTPGTLLSQGAVTVTGTAQIGAGQPVRDTALTYVVDASGSTGSACAGGPTILGCEVGSTRRLNAIAAQTDTVVAAVGAVAFGNGAATIDVRPAAGDQLVTAPGADEDGNGIRDIEDALSSITPGAVSRFTPKTFPAATDYVPAVNAATSVTNAQTQRRKIVLFLSDGFSSTDVRAVASAQPAAVDYLTFAVGTGARCRGANYNSSLQALADLTGGRCTEVLDPSTLPNIVPGVIASQLTDLSLSIDGGTPIAVSSVTPALPRPGPTSVTYSVTTPTLSSGTHSLCVTARGTDGGGAGTVAACTNVVVNNAPTVLAGGPYAGAEGSAVSLAGTVTDPDGPPAAVQWTATAQSGVDAGAACTFSDSQSLTTSVTCDDDGVWALRLTADDGLHTAVVATTTLSLTNVAPSVSVSSPATGTVVARGGSVTVVAPFTDAGRHDTHTCTIDFVDGTAVETGTVSNGQCTASHTSNTIGSRNVLVRVTDDDGGAGTAVVQIVTYVRGESWDLSATSLVPGLLTVAKTPLATCPPSSTQTTASLNVTGLASVSALRADCTLDMTNGRTTATASISGASLLAGAISLSDVQSTCTMTASGPTGASRVGTLNGQSLGTASATISLLGVATIYVNQTTTLPTGELAQYAVRVVTLLGQEIVIAGCRIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T658</accession>
    <name>A0A7W7T658_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KR" evidence="1">
        <location>
            <begin position="232"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="752" mass="80380" checksum="0AF4994BFC652758" modified="2021-06-02" version="1">MTASGVPVRPHLVSFDPDSSARPVHRMTWHPVPVEAAPPVDLTGRRVLVLGVDHDLVAHVGAALAAAGAIVAAPDRDTTDAIDGIVDLNVTGVGIDADGTGDWRRALTATTEALRARYPAWGREHRVDHHWYLAVTAMGGLMGYRHAADGQPLGGVWAGFAKCLPRELPALGVKVVDVQHAAPDVVAAAVLAEIGSWDLFEIGYRDGVRYALTARAEAVEPPAVTLGPDDVVVVSGGARGVGFALARGLAERFGCHVVVTGRGPLPVDAPWFGLDHAAHDEAQRAEIAAARGTADLKRARAAHRRERELRDVRDHLAQAAHDGLRITYEPCDCTDEDQVRALFDRVPTPTVVVHNAGIDEPKRLDLKTADEVVRTVDVKVTGFGNLLRAVLPLRLKAFCNVGSVAGRMGGMIGQVDYAAGNEALARLGFHARDAYGVPVRTLCWPTWDRLGVIANHDAAVRYVSTLAPAEGVERWIAELLTGGTGEVMFLGRVGSALVPGQLRGFRLFTGHPDLARLHGLADHLGVVEEFEPFRRLRCRRAYVPGSHPCLAEVTVAGAPAVPVSVMVEQACALGDWIVPPGWPRQHLVSLDWSLDHRGLVVDGPFGLTAEGSGDEDLWQVTVTVDGAGTVVLTYRPTPPPRPLAPTTPTAPPRFADAWAGLALGRPRWTADAVHLPVTTPADLWTTTFAPPHGIAPTAVETLDRLGARRPEVWPDARDTDRLVVDGGVVFGLHGDTVTLRAPLTRESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T687</accession>
    <name>A0A7W7T687_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diketogulonate reductase-like aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30158" checksum="C8FEB83C87E65014" modified="2021-06-02" version="1">MATTVTLNNGVEMPSLGFGVFQVSSEDTQAALGEALRVGYRSIDTAAAYFNEEAVGRTLAESGVARDELFVTTKLWVDDLGRDATLRAFDASLERLGLDRLDLYLIHWPAPGKDLYVESWKALVELRESGRVRAVGVSNFQPDHLRRIVDATGVVPAVNQVELHPRLSQAGLRAVHAELGIVTEAWSPLAQGALLGEDAIASIAAKHGRTPAQVVLRWHLQLGNVVIPKSVTPSRIAENFAVFDFELDAEDLDRIAGLETGERIGFDPDTFNGFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T692</accession>
    <name>A0A7W7T692_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="7073" checksum="F6DD5AA55B2F1969" modified="2021-06-02" version="1">MNDGRWRKSSHSVGNPEQCVEVAATLGVRAIRDSKDPDKRELSFTDGGFDAFLRTLRRGLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6E7</accession>
    <name>A0A7W7T6E7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19783" checksum="417BA9F6B8A9D81B" modified="2021-06-02" version="1">MFETPDELRSIQVLLDTSLAASSGHLQSIIRAGERTLDAEQVVRVCQGMCTLAIATVTRRGEPRISGADGHFLHGRWIVGTHRQAAKARHLAARPGISATFLRGEQLGIFTHGHAVPLNPEGTSSDPTWPTIRDYLVDHYDGDGDDPFWDESVWYRIDPTWMVAYSADPVGLLDREPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T721</accession>
    <name>A0A7W7T721_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="TM_helix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="TM_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="27841" checksum="E4F61067159AD8D5" modified="2021-06-02" version="1">MGSQITEGLGEAWAMVATFVPKFLGFLLVLGIGWLIAKALARGVDFLLGRLAFERLVERSGLRGAMARSPITATGLVVKAVYYFVLLIALQTAFGVFGAGNAVSALLNDVIAYLPRIVVALVLVLVASAIGKAARGLVVGALGTRPYTRALGAVTQGFIMALGVIAALNQLGIAVSVTMPVLIAVLATVAGVVVVGVGGGLIRPMQRRWEGMLDRVQEETRARPPEQRRSHDPITPSATASAMAGGRRATTMDTPTPPQGFERPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T735</accession>
    <name>A0A7W7T735_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16076" checksum="5246C0616791BE73" modified="2021-06-02" version="1">MSDEARSLTDVVTRLRRALRTSIRSEWPWDSLPMAQIELLQTLAERPPMRVGDLAAELRLAPNTVSGLVGQLIEGGLVARGGDPTDRRVARLSVTPKGHEQLAVWQSAHEKRIGTALDKLDPTEREDVVRALSALDHLVDHLRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T765</accession>
    <name>A0A7W7T765_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-antigen/teichoic acid export membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7724" checksum="55B75599FE6B2412" modified="2021-06-02" version="1">MWRFGFVLWSAWQVLRWAVVCALVLLVVYLVDGVGGWFLAALLGMVVALAGVVAMLRGLYRRELTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7D1</accession>
    <name>A0A7W7T7D1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein with EDD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="28898" checksum="705964DEF6ACB886" modified="2021-06-02" version="1">MSTTIVTDSTAYLPEGFAQRHGIRVVPLHVAVDGESRLDGVDFGPVELAEALGEHRRVTTSRLTPDELARTYREVLASGADRIVSVHLSRELSGTWEAARLAASEVDPVRVRVVDSRLAGMGLGFAALAACAAGDDVERAVAAATDAAARTRMFFCVETLDHLRRGGRIGAAAALLGTALAVKPLLHVDDGRIVPLEKVRTTARAMARLVDLAVAAAGSGPVGLAVHHLATPERAAELATRLDERVPGSGGCLISEVGAVLGAHTGPGVLGVVVLPGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W5</accession>
    <name>A0A7W7T7W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5289" checksum="B89797318B50AE33" modified="2021-06-02" version="1">MRQGHAHPIVDGTPIPMDRIAADRPFHSGKHKIHGMNPQVVASPDGDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X4</accession>
    <name>A0A7W7T7X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein LprG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16334">
        <property type="entry name" value="LppX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030713784" evidence="2">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="21361" checksum="FF02802AB213F5BD" modified="2021-06-02" version="1">MIPRRAFLGSLVLALVVGCSSAADGPAGAEVLTKAAESMKAVTGAHFVLKVDGTLPGVGVQAAEGDLGADGQSSGHARVEQFGQLVEVDYVLVAKDLYIKGATGGFTKVPAALAGSVYDPSAILSPDKGVAKVLSSARDPKTVSSSGGTHVVEATVPRDVVAGLVPGIAEDVAGSFSVKDDKLVKAVFTVSGGAKATIELSDFGKTVTVERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8F2</accession>
    <name>A0A7W7T8F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S) ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07423">
        <property type="entry name" value="MPP_Prp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041780">
        <property type="entry name" value="MPP_PrpE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="103"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="38208" checksum="B0D229D312560B3C" modified="2021-06-02" version="1">MEIEVPDGSLVVLVDVTAPDAVPGRRLDEITRRAAAGVLTLVEGGDRRELVRIARRHHVRPVAISAHDRLRDEGFRPVHLTGGEPFAVRVVPARSDLRHLTGPFDVIGDVHGCADELRELLGLLGYVDGAHPDGRTAVFVGDLVDRGPDTPGVLRLAMPMVRAGTALSVRGNHEDKLVRALNGHNVVVAHGLETTLAQLDDESPEFRREVAEFCDALVPHYVLDGGRLVVAHAGLPERYHGRESAKSRGLAIWGESTGALDDRGFPVRHPWALEYTGAATVLYGHTPVREATWENNTLCLDTGCAFGGALTAVRYPEREIVSVPARRVWYRQVSPASSPTPRAAGRTTREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8H8</accession>
    <name>A0A7W7T8H8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19664" checksum="966F631A8D505BAF" modified="2021-06-02" version="1">MQPLLHAATALAWRGVVVPDVAVLGHRVSAVVRVHADVHAWRAVNGWPPQADPSWFRSWFEPDEHDRLPVPAVELAGVLVGESTVDRALQSCGTLMTLAPCAVVLPATPGSSSWPLIELDYYGIGVVAIDEPGTAELLVAPEDRSTEFGPSLFGRWLLEVLYDRVLREVPVEARVNSRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8R6</accession>
    <name>A0A7W7T8R6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator VanR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="25220" checksum="B4DADE9297804A87" modified="2021-06-02" version="1">MRVLIVEDESYMAEAIRDGLRLEAIAADIAGDGDTALELLAVNSYDIAVLDRDIPGPSGDEVAERIVASGSGMPILMLTAADRLDDKASGFGLGADDYLTKPFELRELVLRLRALDRRRAHSRPPVREIAGLRVDAFRREVYRDGRYVALTRKQFAVLEVLVAAEGGVVSAEELLERAWDENADPFTNAVRITVSALRKRLGEPWIIATVAGVGYRIDAGSDGDRERAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S2</accession>
    <name>A0A7W7T8S2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8160" checksum="94D9E0C5388A7A92" modified="2021-06-02" version="1">MANTARNGMSAASLQGVTWRKSARSGALGNCVEIAELAGGDVAVRNSRFPDGPALVYTRSEITAFVAGIKDGEFDDLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T905</accession>
    <name>A0A7W7T905_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="179"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="398" mass="40551" checksum="0EE2FF5E37128271" modified="2021-06-02" version="1">MSKPLTRVADHKADLAGLVGLTPVVDLPLADCTGLVLARDLVAPIALPPFDNSAMDGYAVRAADVAVTPVVLPVAEDVPAGRGDLVPLVPGTAHRIMTGAPVPPGADAVVQVEWTDGGTATVRIDRSVVAGANVRSAGDDVAPGTTVLTAGTVLTAPRLGLAAALGSATLPVRRPARVLVLSTGSELVEPGRELTPGTIYESNGVMLAAAVREAGAHAELLRFVPDDADAFHAAIADRLGSVDLLLTSGGVSAGAYEVVKDAFTGRGVEFRRVAMQPGGPQGIGRYQGVPVAALPGNPVSAHVSFEVFVRPALRAAMGFADVERPTTTAALSAALTSPEGRTQFRRGAYEPESGRVVTPVGGPGSHLLSALAISDCLIEIPADVTELPAGAEVVLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T927</accession>
    <name>A0A7W7T927_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP:glutamine synthetase adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">ATase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl-L-tyrosine phosphorylase</fullName>
                <ecNumber evidence="3">2.7.7.89</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl removase</fullName>
                <shortName evidence="3">AR</shortName>
                <shortName evidence="3">AT-N</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl transferase</fullName>
                <ecNumber evidence="3">2.7.7.42</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl transferase</fullName>
                <shortName evidence="3">AT</shortName>
                <shortName evidence="3">AT-C</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnE</name>
        <name evidence="6" type="ORF">F4559_005591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18589"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP</text>
            <dbReference type="Rhea" id="RHEA:43716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GlnE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.89" evidence="3"/>
    <dbReference type="EC" id="2.7.7.42" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000820">
        <property type="term" value="P:regulation of glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00802">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="84"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="323"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="575"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="829"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl removase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl transferase" evidence="3">
        <location>
            <begin position="482"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="974" mass="106062" checksum="0B74679A4EA2E035" modified="2021-06-02" version="1">MTESVRPTMSPARFGLTEARTVDHLRAAGWWLDRPTEGSEPVLVALSRCPDPDLALRGVDRLREAVDWPALDAVLRADVVLRGRLLAVLGSSTALSDLLVGNPDLWRSLVDPEPVSSFDLLPAVADRSGADAVRALRLAYRAALCRIAAEDLAHVVEPDLPYVDYDHVAGLLSDLAVAALDAALDVARRQVAKSDECRLAVIAMGKCGARELNYVSDVDVVFVGEGDLGVATRVAGTMMQVAGQACFEVDAALRPEGKAGALVRTLDGHASYYQRWARTWEFQALLKARPVVGDERLGRDYLEVVRPMVWTAAERENFVPDVQAMRRRVEEHVPAGLADRELKLGRGGLRDVEFAVQLLQLVHGRGDETLRIQATTQALAALGRGGYVGRADAADFGRAYRFLRTLEHRLQLQRLLRTHLFPADDDAAGLRWLARSVGFTGEGGQSEARVLLGEFRKRANQVRRLHEKLFYRPLLQAVANVPTEALRLTTAEAALRLSALGYAAPDGALKHIEALTRGVSRRARIQGALLPVLLDLFATTPDPDGGLLAYRRVSEALAETPWYLRLLRDEGLVVERLATLLGTSRLVPDLLVRAPEVLRVLADTSALTGFDPMTIGNPLRSTVSRYNDLDRAVTAARSLRRQELLRVASADLLGLAGTRDVCVSLSQVWVAVLQSALDAVVRAAGPAPARIAVIGMGRLGGRELGYGSDADVMFVCEAVDGATDQEAVKYANSVVERVRRLLSAPSQDPALQVDADLRPEGRQGPLVRTFESYRAYYAQWSELWEAQALLRARVVGGDEKLGARFVEMIAPIRYPAAGLDAAAVREIRRIKARVEAERLPRGADPSTHTKLGRGGLADVEWTVQLLQLQHAGEVSALRTPSTVRGLRAAGEAGLIEDDDATALLDAWTLATRARNAVMLVRGKPNDQLPSSGRDLTAVAAAMGHGDEEPGEFLDSYRRTTRRARAVVERIFYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T951</accession>
    <name>A0A7W7T951_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17926" checksum="A6A98CE2BE5E5040" modified="2021-06-02" version="1">MHALVVFFDEEADARVRELWRRIGATFPYPPHLTYAIAGTIGPKVRAELREDLSRLWLPDLWLHTLGSFPNTLHLGAVVDTELLALHSAVHDVLAGRVKHPSAYYLPGNWVPHCTLLAEADEAAVAAAFAELHPVEPIRARAREVSIVDTQTATIEVLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H4</accession>
    <name>A0A7W7T9H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18232" checksum="2B50C2F91CE54EF1" modified="2021-06-02" version="1">MTAIDELLRRNAELGNAVPGDRSSPKPSMRVAILTCMDSRIRVFEIFGLKQGEAHVLRNAGGVVTDDMIRSLALSQRKLGTREVLLVHHTNCGLELVTEDDFKNELERDSGLRPPWSVEAFREVKDSVRGSVNRVKHSAFLPHRDLVRGFVYDVHTGALTEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q9</accession>
    <name>A0A7W7T9Q9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA invertase Pin-like site-specific DNA recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="192"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="509" mass="57302" checksum="FBA0FAC06D8B26D0" modified="2021-06-02" version="1">MATSRPRRAGGRTQLDIVPDQLIWALYGRDSLDPKGTAVRVTNQLAELRPFALGIGGRIGEEYPENNVSAFKRVKVMLPDETYGYRVVRPDWDSMMTALRRGEYNALALPNIDRGMRDPRDLEDLIDLVEQYGVYVVGMTGTIDLTTDEGISSARREVDQRNRESRNTSRRMADGNRKAAMAGKQHGGANRPFGWRKDRTTISKREAAHILREIPRLLGGVHPRTIAIEWGERGIPTIAGGKWRMMTIRQIFTNPRLCGWRAYLGEVLRDEHDNPVQGQWEPIITVEQHLALVAKLIPSDSPELPKRGRGHVTRRLLSPFARCGMCNSKMTGGSRKEKKTGERIPIYKCPPPGFGGCGRVSRTCAPIDRYITALVLAEQSRIQLGRADELPPWGREAELKAVTDQIKESTTAYKKKLISGGRYFPLMASLEADESKLRAEKRKYEAKRQARVSRAANLEAEWSRPDFTLEQKQAAIARSLTAVIIHPAPHPGARFTPDQITPVWREDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T3</accession>
    <name>A0A7W7T9T3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">F4559_006460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4969101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19311" checksum="38C8BB88D09C0823" modified="2021-06-02" version="1">MTLRLPEWRTRAACRGRFDLDFVEPGEQLAECLALCAACPVAEQCLAEALDAGEAWGIWGGLDAERREQLAEQTGHPAPAVRPAHGTNSRYAKHGCRCDLCREAHTAYDRQRRARNRARVGDPWVRPIVLAERVRTGHTWAGPGQLLLPLPGVPLPVDVEHQDDQQPGVETIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9X6</accession>
    <name>A0A7W7T9X6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized membrane protein YccF (DUF307 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13378" checksum="40205CD924F66C7E" modified="2021-06-02" version="1">MRFILNVLWLVLSGFWLAVGYVLTGLLCFVLIVTIPWGRAAFRIANYALWPFGRTVVDRPGAGAPSVVGNVIWLLVAGIWLALGHLVTGALLCLTIIGIPLGVANFKMVPLSLMPLGKQIVDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA34</accession>
    <name>A0A7W7TA34_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031422353" evidence="2">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="30462" checksum="76D81D59D4CC4E5D" modified="2021-06-02" version="1">MIDPRRLRVLRALADHGTVTAAAAALHLTPSAVSQQLAALEAEVGHALLRRRGRRVSLTAAGELLVRHTVVIEAELERASATLAAFASGTRGEVRIGSFASAITQVVAPAMAALRIVAPEVVLRVRDVEGHASMPLLLDGEIDLAITEEYRPRAGDRRVTRFPLYTEPFDVVLPPGHPLHGQPVEIAALADDDWVTTLPGNPVRDAVELACANAGFAPRITHTSDDFRAIDALVAAGAGVALAPRHAVSGIPVQGTAPLRQVFAAVRRGSEEHPLVKLVRDALTGMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA65</accession>
    <name>A0A7W7TA65_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="32036" checksum="3A3387188B710840" modified="2021-06-02" version="1">MALARPTVERIQLGLTLSRLRTDARKSQGEAAAVISRTAGRLSQVENGRGGLGPEELLRLLDFYGVRGEERQTVLALGVASRKRSPRRGYVDNLPEPFKRVVDMQASAARISWYECGIIPGLVQSPDYVRTIMALGNGIYWDTSEEETEERIAFRLEHHRRVLETGEPKQLAVIFTEDSLHHPIGGTSVMRGQVLHMLQLMERHPLLDIRIVPTTTVDNPALGGGEVLLDFSGSSTIGFVSVLHGPATYYDQLQDIEPMQRLFQRVEELALSRDDSQALLADLVKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA79</accession>
    <name>A0A7W7TA79_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Superfamily II DNA or RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="533"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="817"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="990" mass="107840" checksum="8DC92E1264E156FA" modified="2021-06-02" version="1">MWVLHGVCTAGGRLGFWAEDSRLPARTGARLPARPVPHPFAVTAADLIAARTRADDPDPTTAEPGGPHPDEVVLRLPSVGTGPAASPELVREPVGGGTSGRGALRWREWVVPVVPVDGFPLPGCRLGASGRYLLEILDFGADLVRRGRVVPVVDRTEAATRWRAVLSGVDAARAAALRAGMPPSFRAGGGADLFRVALDAIVDREARKALGELKNSSSHVVDAWVAAAGAGDGRFAAERGAVVELRERLRRWGADGFAEKPVRLCFRLVAPLQGAAHEEGWRLEFLLQAVAEPSVLVPARDVWQRGDAVLRRWVPRPEEVLLADLGRAVRLYPGLDRALAAKRPARLKLDVDGAYDFLSRAALLAQAGFGVLVPSWWRQPRRLGLTLTAAPRGAAGIVATESELGHRAIVDFRWDLSLGDEKLTQAELMSLAKAKAPLVRVRGQWVHVDRKRLAAGMAFLERGAGGEMPAAQVLFQHDREAALPLPLNGVVGRGWLADLLAPDAEHRLEPVPTPPGLTATLRPYQRRGLAWLVFLDRLGLGACLADDMGLGKTVQLLALEAVNRQDGKRPPTLLVCPMSVVGNWRREAEKFVPHLDVHVHHGADRDPVRLLGEHDLVITTYATVTRDAAELAAITWDRVVVDEAQNVKNSATRQARAIRALPARHRIALTGTPVENRLAELWSVLDFVNPGMLGPLTTFRARYGVPIERHRDAEAAVRLRRATGPLVLRRLKSDPRVIGDLPEKIETTQSCTLTAEQASLYQAVVEDMFARISEIQGVKRKGLVLATMTRLKQACNHPAHLLGDGSPVPGRSGKVDRLEEILDEAFADGDKVLCFTQFTAFGSLLVPHLAARFDVDVPFLHGGTSRRDRDAMVRRFQSEDGPGVLLLSLKAGGTGVNLTAANHVVHLDRWWNPAVEDQATDRAFRIGQDRHVQVHKFVCVGTLEERVDRMIEDKRGLSRLAVGAGEDWLTELSTERLREVFALTPEAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAM7</accession>
    <name>A0A7W7TAM7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031597020" evidence="1">
        <location>
            <begin position="34"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="374"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="575" mass="59852" checksum="3632F10D477978F5" modified="2021-06-02" version="1">MNDFRRTARRAGTLAVTAATGLALLLAQAPAQADNKAPRTVDVRLIGINDLHGNIEPPTGSSGRVTLADGTTVDAGGAAYNATHIKKLRSEVRNSVVVGQGDLIGASPIVSALFHDEPTIEILNDFGLEAAAAGNHEFDEGYKELLRIQRGGCHPTDGCQFRPGFEGADFPILGANVTLAKNGLPALPPFWVEFRDGIPIGFIGLPLKDVPILVDPNGIKELKFGDEIAAVDKYADLLNRLGVKSIVLLIHQGDNTTGGGPDECRTVAGGPGRVIAEKVSPKVDAVFSGHSHQHYNCTVTDPAGDPRPFIEGLAFGRELSVVDLKIDRKTRDVIRPATKSRNHVVTRDVVADPRIQSVIDLAKSKSGPIANKQVGTIASDIVRAQNPAGESPLGDLIADSQLAATQGNGAVLALMNPGGVRADLSYASSPAGEGNGVVTYGEAFTVQPFGNILQTVTLTGTQIKAALEQQWSLVNGAVKQTVLQPSAGLTYTWSASAPIGSKVSAIVLNGTPLDPNASYRVTINSFLQGGGDGFSAFTGGTNITGGGIDLDAFAGYLASHPNATPPALGRITTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBH1</accession>
    <name>A0A7W7TBH1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="12607" checksum="AB58607CAEA1CD80" modified="2021-06-02" version="1">MADAEESLARAVTEALARSAGSGLWDDLRAGVSRALSPARPEALARRLDADRHRFGSTAARWQGSIEALLWEHPEAAGALRALIGSPRPPEPGRSVTQNATASDHSRVYQAGRDIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBH7</accession>
    <name>A0A7W7TBH7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010910">
        <property type="entry name" value="Nitrate/nitrite_sensing_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50906">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="NIT" evidence="6">
        <location>
            <begin position="73"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="821"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="898"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="927"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1103" mass="118239" checksum="D3A980570BBA7956" modified="2021-06-02" version="1">MTESTSPRSASDVRAAGPGSAWRLRNWRLPTKLAAVLLIPTVAALALGGLRVNSDLAAATEFNRLANQIQLEAAVADLVQQLQRERDLSVSHVASGKKLDRVVLDRQLRRVNDTTDALNNKISELGGDLDDEVLTRFRRAAEQLKRLNSLRNAVRDTEYPSEAVLRTYSESVESLLDLGEQAIAGIDDPELVRLHLATNAIARIKEQESLKRGIMLDVLQRGEFSAGQQRALNTASAELDAARNDFRKSATPDQAKIYDDTVTGLIVDTANDMQETALNLAANNKNLSALRPEKWDIAATLTVNLTREVESLLLEQLQTRTDELTGEARSAAFRDSGIVLGALLLALVMALFVARSILTPLRTLRRTALDVADHGLPEAVARILADPDPQQAAKSAVAPVPVNTREEVGQVARAFDAVHDEAVRLAAEQALLRDNVNAMFVNLSRRSQALVERQLNLIDRLEQDEQDPDQLASLFELDHLATRMRRNSENLLVLSGTDLSRRLTRPVPAAEVLGAAVSEVEQYARVQVGQTPELTVQGRAVNDLVHLIAELLDNATVFSDPVTKVTVRTARTRRGELAIEIQDRGVGMSEKDIVDANQRLADPPDVDVAVSRRMGLYVVARLAKRHDIKVRLRANEDIEGGTTALVLVPENLVQAPGAAPSPVGYEPAFPGLGGPTTDSGFPGLGSPAPTTQNPAERASGIAGAFTGSMPRLDDDQQSSSPNLPVSFVRSEGEADAAGLPSFGLAEPEPTPEETSQDSFQPWQPLPEEHTGRDVEHEPVGSFGEPMLFTAYEDRDDEESANGHGFETTQFAPILDSTVHVGGFLDLDSEPEPESTDPSPADEDGWSEATPEATPEATPASTGETGGRRVVPDLDAPTERLPIYEAVLSQWFQAVGGETPASTARAVEPAPEPESEPEAREETALPTRKPQPVPPVAPTTTEDAPPAAPEPPSAPVLTEGGLPKRQPGAPGNKPGRTPADRTPEPVAVPEPVAAAPEPAWSSPADDGWHAAQALLSRVPETTTQAGLPKRVPKAQLVPGSAAPLAPSPEAAAAPVPQGPALPPRTADAVRGRMSSLQQGVRRGRHALIDAYAGDMSSRQDEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTL0</accession>
    <name>A0A7W7WTL0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="7" type="ORF">F4559_000181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="47868" checksum="837C60DDA649CDAA" modified="2021-06-02" version="1">MNTAQLLADDPLWLIIVKVVGIFAFLVVMTLFMINWERKVVARMQQRPGPNRVGPGGWLQSLADGLKLAFKEDIRPVLADKWVFFLAPVISCIPAFVAFSVIPLGGKVTIFGEETALQLVDLPVGVLVVLACSSLGVYGIVLSGWASGSPYPLLGALRSAAQVISYEIAMGLSIVAVVMHSHSLSTSDIVKSQGSGWYFYLLPVSFVIYVISMVGETNRAPFDLPEAESELVGGFHTEYSSLKFALFFLAEYVNMVTVSALATTLFLGGYRFPFVGDDHLLNSGWFGLLWFVVKTLGFLFLFIWLRGTLPRLRYDQFMRLGWKFLVPIALVWFVAVAFARYVRREIEQGALETSTALVVIGVVLVAVLLIAFMLPDRRARVDPNAVPVTGGGYPLPPLDLEVPKSPPRRRQVPVAQLPAKENTAVTVSAKEVGNGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ1</accession>
    <name>A0A7W7WTZ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mycothiol system anti-sigma-R factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10392" checksum="F0F66D7C7965B2D2" modified="2021-06-02" version="1">MSCGNHETDCSEVLSEVWLFLDHECDEKRKNLLATHLEECHPCLEQYGIEEHLKALLAKKCGGEHAPEELKQRLRDKIRQSQAAAPQPTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU38</accession>
    <name>A0A7W7WU38_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="40043" checksum="70AE22F7E23610F2" modified="2021-06-02" version="1">MTTPLSVLDLSPVVSGSGAAEALRDTIDLAQHAERLGYRRFWVAEHHLVPGVASSSPAVLIALIVSATKTIRVGSGAVLLGYYPPLLVAEQFGTIAHLHPDRVDLGLGRSGFVRKDEVLKKFAAPAVPTPARVVDGLLIPERPTLAFRSERFWERYEARERLLGKRDPVDYTDQVTQVLGFLEGTNGDGFDVPSARDAALDVWVLGSSAGASAEAAGRLGLPFTANYHVSPTSVLEAVEAYRAAFVPSHRLARPWVSVSADVVVAPDDDTARELASPYAQWVLSIRDSRGAERFATPAEAATRTWTDDERKIVADRIDTQFVGSPATVVERLHALRRATKADELLVTTVTHDHADRVRSYELLADAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU71</accession>
    <name>A0A7W7WU71_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein F4559_000542</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="6898" checksum="1C7A747968862091" modified="2021-06-02" version="1">MAVRLDDRLLEILVCPCPDRAPLTAGTPADPQADFLTCTSCGRSYPVVDDIPVLLLDEAVEPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD3</accession>
    <name>A0A7W7WUD3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="35" mass="3914" checksum="D11532400B3F9A08" modified="2021-06-02" version="1">MMTTKRRCREPIHPDVLIFVFSSQEVAAGATPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ4</accession>
    <name>A0A7W7WUQ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19384" checksum="32071896374FF4E3" modified="2021-06-02" version="1">MMFTACSKTTTEGNPAPATSLATTKQTPSPSEEKQPSGNDLDITKYADKPCDLIKPDQLATLGNFKPAKQGAGPLGPTCTWLGQNSIKDNTYALSLVTKGSTLEKMRENVKDRTIFKTTTITGRDAYSTDGTDGTRDCATGVKTSSKDAILAQVSLGEKDTEKTGKSCQASERLAAIIIGNLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT6</accession>
    <name>A0A7W7WUT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="626"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="869" mass="90994" checksum="57D32DD1EA134E27" modified="2021-06-02" version="1">MVALSAAAALEARQRDPRAAIEIGRAALRSARAAGDAREASAAERAIGLSLRELHDLDGALRHLRRSVRIAVRAGSARSAALARMSLAFVLSTTGRHAAALRAINAALPDLRGTDAGSGRMQRGLVLHYLCRYDEALREYNAAIDLVRRSGERLVEARALNNRGLLRAYTGGLRAADEDFDRAAVLYRDLDQELAVADVRWNAGISASRAGDVPRALTMFAQAEREYRRLDVPRPGLLINRLEVLVSVPLVEEARAAADRALAELTDDLVLARSEALYYRARIAVLEGDLDVAATMAASARAGFRRQGRAVWEAGAHHVELRAAYLDGKRSRRLATALTRVADRLDALGWRTAGLEARVDAALVARDLGDRGRAAAELAVAGAARRGGPAAARVLGWYAEAVRRDLAGNRRGAQSALRRGLGLLDEYRVSLGAGELRAVSGAQGKALALEGLRGAVASGRADRVLAWVERWRAGALRMTPARPPEDTGLADALAELRATTADLEAALLSGRPTTALRQRQVRGEQRVRELTRQASGGGAVLRPPAVRDLVAALGDAALVEYVDHEGALLAVVVAGGRASLHRLGPVDVAVREVRLLRFALHRLVTLPERVDRSAVRAGAGHAAGLLEARLLAPLLRRVGTRPLVLAPTGVLAGLPWAALPGLSARSLTVAPSAAVWLRATAARPARGSAVLAAGPRLAAAPAEIAAITPSAGPATALVGADATVDAVAAAMDGAALAHVAAHGSFRADNPLFSALELADGPLTVYDLERLRTPPARVVLSACDSGMSAVRPGDELMGFTAALLGLGTRTLVAPVVPVPAGTTTPLMVDFHRGLGAGLPPAEALALARVAHLDEGDSAYAASVGFLCFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV4</accession>
    <name>A0A7W7WUV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002044</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024282">
        <property type="entry name" value="DUF3376"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019894">
        <property type="entry name" value="Patatin-related_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11856">
        <property type="entry name" value="DUF3376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03607">
        <property type="entry name" value="TIGR03607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="891"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="915"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="942"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="972"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1016"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="13"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="249"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1204" mass="129927" checksum="65F37CD0468F19AA" modified="2021-06-02" version="1">MTNMPREQIRFAVVLNGGVSLAVWMGGVVLELDRLTRSLDGYGDLLDLVGSTARADVISGTSAGGINGAALALSQVNANAKLERLRDLWAEQGRMEQLLRTPFRGAPVSLLKGDEFFLPRLREALERLAADYSPTPAADRPVDLRITTTLLAGVPTVTYDDLGQELVQSSHQGSFSFRRDPAGRDDFRPGAVPDLVERMALAARSSASFPFAFEPSYVPVGASVDGRPDMAAVASWADGESDLSRFVVDGGVLVNTPTREALEAIDRMPAEGPVRRVMLLVFPHAPDTSTDVVADGVPSTLGTGGRLLGALTSQGNRTYVERIEEHNRRAASRRGGRNALLDRLAGDGSVTDKLYALTDTLHDHFEDVRMRHAARDLTTRQLAVVGSNKAGWTFERVRAAAEAAQRAYRKKRGSLPYVPKESLPFAAPGSGWPWGISMAERLTAAAMDLLKRMVWVVPDTREEPFAKACPSIAGARTELYAIRTELREARRDVDAHWQPGVAENLDRDYWTRRIDGYAATMLGADSPGDRVRTLVERIVAVFGVAHEILPLLDDTRLDMGGLRSWCKLLAEPPTEAEAGLSAEDVRLSRVIALEIAATCLADDERDGMDQAVELVQISLRTRNAFADYSITPDDKAGGASLGRFSGFLKRSWRVNDWIWGRLDGATMLSKVIFDPRRLVRIDKLSGAHEREPDPAKRAASTVADLVAKLFGEVPDRLVPAVDKAVAELTAVYANPDDDHPPTCPALAELAAWALHVHIICEELPGLRAAILADRIEGADRRSRGELFLEEHDRLLAKFPVRTQADRVTVGLEALEAFDRAGIGREPLVQEAGSDQVIRTAATAAAVAITVVDGENSGFGPAKPLTRALRGAALLPYWTITGLTRGGRLAQFLGLLGFALGGALLVLALFDLLPAWAVGPAAALGGGTVLAAFGYAALRTGTLLHGLVLLAPVLPLAVVAVDGAREHIGSGDGSTGAVAVGGVVLVVLALLLIGSLPAPVGTPLAVLRRIRVEPRTLVRAAIVVLVGAGVWAVIRWRWYDLAPLWVGVAWLGSTVFGGVAAYWLGSSLRRWRRLGDTWRTEDAQPPASATAGWSAVYGAGFLAVAGVIQVSDLRFEGWEAVLGTALAFGLVLLLVTTWWVPLRTRRAIERQLAEFDPEGRPTAEALFKRLEGNGMLFKFLVVVKNGKPVLNPAGRRLVRRIDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB8</accession>
    <name>A0A7W7WVB8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28761" checksum="3F5F8B6606261215" modified="2021-06-02" version="1">MDALPLSLADVSVEIAGATLVRALRLDVRRGEVVGLLGPNGSGKSTALRCVYRALKPTSGAVLLDGEDLAGRGLRETATRIAALTQDNRAELDFTVEEVVALGRAPHQGGNLRLSARERELCREALRRMDVTHLAKRSVLTLSGGERQRVLVARALVQEPAVLVLDEPTNHLDVRHQVELLRFLRDCGLTVLVALHDLNLAAAVCHRIALLKEGALVACGKPAEVLAPDMVRVVFGVEVTPVVHPETGVPQLLYDVPVDGTATAEGNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE5</accession>
    <name>A0A7W7WVE5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease BN (tRNA processing enzyme)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25908" checksum="E225302B4CC07946" modified="2021-06-02" version="1">MELTVLGCGTPYPRPGEPCSGYLVSEGDTRVMLDCGPGTFAALQEHLRPGDLSALWISHLHPDHFADVLSFCNWALNTADAPRLAVHGPEGWAGRLEAVLGADVSSIFEVREHVDGRAVEVGGLRLVSRAVRHSVPAFGVRVEGRDSVLCYSGDTAPCAALVEAADRADLFLCEAGSAVEADAHSTPEQAYDLARAARVRALVFTHLAPGLDPRRVDAARYPDLPTSVARPTRPGHTGGSTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH0</accession>
    <name>A0A7W7WVH0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="507" mass="55723" checksum="B17038AA63B08EEF" modified="2021-06-02" version="1">MRDLYALDPDGVHRDMWVLSDLDPGSVGQSVRFLRNQAVRYDKNEQRLRAVSSGSGRMEMRGDYAREYTRVLKELPAGPRRLAIAYAEGAKVLDDYAAVLARTHAEVHAAATTAQLADTGYRGALAAFCSLVPVTLSGTGVWRGLNQQSARTLSAGLPPPVPDYAVKLGSQAEQAETTRRNAQRQALFATACHRAAALLCAAALDSAADFAGGPGGDIGRGGRPGGQRHFLLSAPTLSDPGQSRDGRARGDFRVLRRWARKLRAQGVASVREMDGNSVKDSRRRPRERAITTARYRRGEFEKVVKVYNFSGQKHDWTPADRAPDRPDKGRLFETSPAPSYDPKARDWSVDGDRDRTHDAEAKLFEDLARLHLREYSGLSASEVDQALEKAARQVKSLDSVDGKFYEPNLRGQLQRTQDRLDLAISELNKRASKKAEGKGGSYSPFVAEDISGDLRMIVDLPSAKLDGVPPEFQVCLSCQKVMIAYESAFPGVRLEVVNLDGERLYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ0</accession>
    <name>A0A7W7WVJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="50819" checksum="308E1CC5B9F2B2E8" modified="2021-06-02" version="1">MCGYCARAAGFRNPIPKGFYEDADLRAALARYDFGAVFAAVRQHTGLSQLQLAALLDLSQSRVSAVERGERRLTHVKLVARLSTLLRIPPGLLGFTVGTGGSVTTQEEVSWLERRDFLALVTAATLGSSLHPELARLGSLLPDQVEPVTRPRIGAADVDAIEAITDGFRRSDFAHGGGLCRAAAVTQLHQVRRLEDAVCTPEVRTRLLVAVAELAGMAGWLAYDVEDHDAARRLWTYALDTARRAEDHPRAPDLAVDLLLDMAHQALHLHGLDPVAHADRAGEALHLVQLASATAANRRHPVSTITSGYISAVLGWCRAALGEAEPTRRAVGNAQDIYAAADPATTPPWAWFVTDAEITAQQGHSLYLLSLTRPEFAPEAIEKLTSAATGYGAEYERSRAVILPPLASVQFQAGDLDAAVSTGYDAVDAITGLSSTRGYARLRVLDTVAAPHAGRPEVAELREHIRRTPAGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP7</accession>
    <name>A0A7W7WVP7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative GH43/DUF377 family glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="493" mass="53610" checksum="ECA679027F8CA823" modified="2021-06-02" version="1">MSAVVTRISPLLRPDPRRVITKLFVPGEERPEHESRSAAVIRRVMALDEETVCAALARTVRLFADRHRDVRATFADHFASVSHRLPAGVVLSEARRLLLGAYFTHEYAVEGAALCNPSMVAHPDQSGLTPGHLRFVLSVRGIGEGHLSSIGFRTGVIGPRGTLTVEPPSDVVTTGLRGDPVYDKPLFLGKLAELGQDDEVSAVLNRWLPARFTGAELDLVLADLHPGLAARREAHRTVELIRWIAECNYTSEFPVDTDVSGRVLWPTGPSERQGMEDARFVRFTDDDGDRTYYATYTAFDGVDVAPQLLRTDDFRTFQVTQTTGPAARNKGMALFPRRIGGRFAALSRGDGESTAVTTSDDIGNWSDSRPVAAPGGDWDLVQVGNCGSPIETPEGWLVLTHGVGPMRVYSMGAMLLDLDHPERVLATLPEPLLLPDPDERDGYVPNVIYSCGGLRHGDTLVIPYGASDSTIGLATTSLRGLVAALTDRRTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW98</accession>
    <name>A0A7W7WW98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23630" checksum="9D34EDAAD50D8EEA" modified="2021-06-02" version="1">MTARLLDDDALARSSVVANCAMNRERRLSGTNGYGRELGIDVARLITDRLAHADSFRWLDLCCGSGRALLECAALVDDDRLTITGVDLVDFFAGPAHPRVEFVTAPIGSWAPETSFDLVTCVHGLHYVGDKLGVLARAASWLADDGLLIANLDLASVVSGQGHRKVVGALRAAGFTYDGRRRRIGRTGHGKVRLPLRYLGADDRAGPNYTGQGAVNSHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWE8</accession>
    <name>A0A7W7WWE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="110" mass="11438" checksum="32A3955384BFEA05" modified="2021-06-02" version="1">MLSTGKIARNAAKCPSAPGATCSRCGAGPAGTPRRRVGSDLGVWSAKRLTVSRTVTLPCARTTGVSSRAGRTGAVAGRSCHCPTIRSHEWVSANARARRESARSASRSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK1</accession>
    <name>A0A7W7WWK1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="379" mass="41353" checksum="8A5CF3AF24FE7EFB" modified="2021-06-02" version="1">MNRSVLSGNELFLPARAVVLQPETLCNLDCSYCYLPFRQRRNRMSIEVAQAVADSIRAWTASATVEVCWHGGEPLATGRTYLSKLMDCFNGMDVKHSIQTNATLINESWCRFLAGRQVHVGVSIDGDNSDNVNRVDRSGRPAYGKIVRGIREPVDHGHEVHAIAVVSDPSAERARRLYEFAASLGISELGVNIEEQEGVNATVNAHDRAEVIGFWSELTRIWAENPVLRIREVARSLGCIGAVLRDDSTVIRTGPAIDPLPTVGYDGSVTLIPPELAGFSGPHGSFATGSILVDSLDKIIARSEGSRWIAEFARGVENCRASCAFFDFCGGGHPANRYFELGRLDTTETNYCRNSKIALLEGVLKNAQPDAAGRTHPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP2</accession>
    <name>A0A7W7WWP2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="95"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="41358" checksum="A3CCB438EB2AEA39" modified="2021-06-02" version="1">MDETPRQRADATSDGRVVQAGRDVSFTVVYRSGPPSWPVVAWAVGLPVVGAIVVVRGGFPVDSVLVWVLLAVAAIVVLVRRRPRTRTRQAFLVTSAFSQKYWIAGLVQHMHGVLDRSGVDLVLKVPDHDYDAAAQAHHLRRVAANRDRYLGGFVIATEVHRLRAEFAEFCAELAVPVVFTDIEPFADDDHYPDNAAFVGYDSADLGARAGQWLRAHLRDRPAPIVLIVACREHEGRQTGCAEVLRAGLPDVSITVDDSCAFNRSRAYSALLNHIRVLERTRDTLDAVFCTNDEMALGVVDALDATDSPLVAHTVVVGVDGTAEARSLIDSRTSPLRATVVQDSHRLAESAMHVLERMHARRPTPKRTILTPEIHQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX5</accession>
    <name>A0A7W7WWX5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17126" checksum="D1A6FFF6662139A4" modified="2021-06-02" version="1">MGKYDHLFVENMLECGDDLVNEGAAAGGERPANIGFPWGLMRGIDVSASTVHMAYSWINPTSEKVHWVNDHEHTYDEVLMWMGNNPDDPHDLGAELYLDIEDERHVVTTTGAVFIPAGLRHCPLGFNSVTRPFSFIALSLSPAYSSDENVPRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX65</accession>
    <name>A0A7W7WX65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20540" checksum="E1E1ED8F8233DCA2" modified="2021-06-02" version="1">MRTRRPFARLVLGLLIMVPGGMLTEQVFARVRYPGAGFGGVPLSFDLQRKYEALDTVERNGFLGQFVLVQALDVTIIVGTLLVFTALTLLAAGRRDAGARVRRLGRLTTVAFVLAPAMDALENASMLALIAFRDRNPDWLNFLQSCCTLGKTVFFIAGWCGLAVLLAAWAVDAVRGGRTSKRHVTNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX96</accession>
    <name>A0A7W7WX96_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RAMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040843">
        <property type="entry name" value="RAMA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18755">
        <property type="entry name" value="RAMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAMA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13760" checksum="608C288A2E7A89CA" modified="2021-06-02" version="1">MMHLYIDAAETLSREAVLTSDRPGSSPLRWAGTVLRDLMSADLLTYGEELVWERCAGEVRHTARLRIDGTFLLADGERVFATPSAAATALSGKHHHGWSAWRRTSDGRSLADLRADLRTRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ3</accession>
    <name>A0A7W7WXZ3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="11" type="ORF">F4559_005239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="186"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="40263" checksum="94E245ED57F11C62" modified="2021-06-02" version="1">MARDYYGMLGVARDATPEEIKRAYRKLARQLHPDVNPNEEARFKEVTAAYEVLSDPKKRQVVDLGGDPLDQGGGGGGRDPFAGFGLGDIMDAFFGAGGGAGGGRGPRSRVQPGSDALIRLAMTLEECAAGTSRELTVDTAILCDVCVGSGCADGSAPVRCDTCGGRGEVQSVQRSFLGQVVTARPCPVCRGLGEVIPDPCRQCAGEGRVRSRRTISVQIPAGVAEGMRVRLAGQGEVGPGGGPAGDLYVEIEEVPHEDFERDGANLHCAIRIPMTTAALGAVLSLKTLDGEEELVIDPGTQPNTELVLTGRGMPRLRSTGRVDGRGDLHVHLEVVVPTKLDARQTELLRELAVARGEDEPSLSHNGKGGGLFSRLRSGRGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY41</accession>
    <name>A0A7W7WY41_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7385" checksum="0E148248B885F2C9" modified="2021-06-02" version="1">MTETISSRMPTPEEVDILDLPSGEPVMILTRHTFTKNDVPIEFARGFHAASRFEWTYSFQLPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYC0</accession>
    <name>A0A7W7WYC0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9046" checksum="47FC6D7197F8C617" modified="2021-06-02" version="1">MNRDAKRPLVPGAGPLARVPAPVVFLLVLGLFTVGVLVRGPVGAAVLGVLCLGVLSLLVVTWPLLPVPARALRVLVLAILVLVTVSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR1</accession>
    <name>A0A7W7WYR1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5919 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045697">
        <property type="entry name" value="DUF5919"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19319">
        <property type="entry name" value="DUF5919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5919" evidence="2">
        <location>
            <begin position="152"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="33544" checksum="3DF81D0F3EE77BBA" modified="2021-06-02" version="1">MPTESTLLKLLLRQRHMQGYRTFCKEYDRMAKQLDGDLIGAYPSKAQFYRWLSGDLLGLPYADHCRVLEKMFPGWTAEQLLAPHTGDAESLVTPTATRSDAAHHDRPAPRPIQLPQQVRLADVTAIYPSRTDFLHNVTPQALFVDAQDIRIAGLSLNVLCQQYSDKLLLTSIQTGTTVKALFLDPNGRNTTAREHEEGLPEGHLSMLTRLNIEALRRVASKVPPDAQGSLEIRTYDEPIRYSILITDHTKCVVQPYLPDARGVESPTLVIEKDDTVPGLFATFSQVFESMWDRAQEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ88</accession>
    <name>A0A7W7WZ88_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ALGX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031811">
        <property type="entry name" value="ALGX/ALGJ_SGNH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16822">
        <property type="entry name" value="ALGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ALGX" evidence="6">
        <location>
            <begin position="145"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="432" mass="47454" checksum="1C3EB913B0AD6DE8" modified="2021-06-02" version="1">MSVESSEGPSRVALDPLHESFLPQEHALYRPRHSPRQRTALITAVVYLCLPALLLVVGVRPEEFENRRLAAFPSGWDLFTGLDEWAADHLPFRKEAVEASGAISRGVFGEQPRFDRRPTEVAGPVQTQPKDPSLDRPDPTSYVEVLEGKDDWLYLGGDVKGACSPKTPTDDVLDRLARLRTAVEASGRKFVLVVAPSKTTVVTEYLPAKYYGKECLTKARDHFWAGVDDKRVDAIDLRDDLAAEAKRLGHPVYTKNDTHWNHDGALVMIRAVADAVRPGTTRTWQVDPARKIDREGDLARLLGRTASDQYQAYDLKPDGSTVCSRPVTGDERKPQRFTQARVPGVVEAKVGWIGDSFTFAAPSYLVAGYTDVTVQHVSGVTADAGQVARMLADTDVVVVEAAERNLLDGTNPILTPAVLDAIGGELAKKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZG0</accession>
    <name>A0A7W7WZG0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="45"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23480" checksum="8DF6B4D9F1A77251" modified="2021-06-02" version="1">MARKTVLKLMNTLGLVCKVRRPRRHRSWQGQTGTTAGNLLNREFGASSPDTKWVTDVTEFRVGDRKIHLSPVIDLFDRSVIAYSCGLSPSLELTNSSLRAAIATLPAAARPLVHPDQGFHYQHVTWRRLLADAGLTQSMSRRGNCLDNAVAENFFGHLKEELFHHTTFDTVEEFTAALHEYIDWYNTTRISTTLKGLSPVQYRAQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZK1</accession>
    <name>A0A7W7WZK1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="26"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="300"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="433" mass="48090" checksum="F3C2B4604F63C608" modified="2021-06-02" version="1">MNPYHSSDLFVGRHNHLARLNAMLDRGRSVLLIGGRRVGKTTLLRRVEVGRTLIRTDTTGWDLHDESTALGALLGALKGGDHPAATRPDIRDALDDVRPLALVIDEADRLLQTRWGPGFFAYLRYLDDTYLRDDIAVLLAGGPVLASFKDPDDRGSPPLNTAETSHVQPLDRAAVAELAENADVDMVFDQAGGHAWLTVRLLAALWDGQDQEEALDTVFDHAVTTFHAWHRQLGEDGRDLLRELPMTRQALRASRWREAAVVGRCVGAVRYVDDVLQPGPRIFTEWLLGRPEDELAYDLAISYASEDTAIAHEIQKALKPHFKVFYAPDEQGALWGNDLHRVLPNVYGARSRYVLVLSTNSYVTKHWTRLEYDSVTANTPGRVLLVDFGTLPEDRPAGMVYRGSSPGQLVALIDALRAKLSEEVGQQPPHGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZL5</accession>
    <name>A0A7W7WZL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
            <ecNumber evidence="2">1.5.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.38" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="19374" checksum="54F4C20EC1B28E68" modified="2021-06-02" version="1">MTVTVVGIGGSLRPNSQSERALRIALAGAADAGAKTVEVVGPDLVLPFYDPAVADRPDNARVLVEALRAADGVVLVSPGYHGTVSGLVKNALDYIEDLRGDDRPYLDGRAVGCVATAMGWQASVTTLTALRSIVHSLRGWPTPLGVAVNSHDVEFDLEGGCSDPVVADRLRTVGRQVAEFAAARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZX5</accession>
    <name>A0A7W7WZX5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="44"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="408" mass="45867" checksum="B105EC8EA90E3A71" modified="2021-06-02" version="1">MLIRFEVANFRSILDPVELSLVAVDRDRPEARPQPNLNESLLPVAAIFGPNASGKSNVIAALDWLITAVGSSLRYWDETIPVEPCAFDDATGQPSEFVVESIIGGVRFAYVVTLDREKIHYEALFHYPERKRRRIFEREGEVLKFQRGLGALSGTRELLTPRTLVLSIARRFDEPLIRDFVLQLTRTTTLGLGRRHPKAGRMLEGFLHPSAQMKLDLGPDLDDTPDPSRDQVLALLRMADLGIDDVEFVTGPHGRRIRLVHRSIDQRIPFELEDESQGTRTWLRLIGPVLNALGKGTVLLFDELDASLHPTLSAQLIRLFQDPTTNPRNAQLIFTSHDTSLLNHLNRDEVWLTEKTEKGTTRLGALAEFAGERVRKSQNLENAYLHGRFGALPDVDRTEVLRALGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZY5</accession>
    <name>A0A7W7WZY5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="33845" checksum="3940C3C5EBD24A29" modified="2021-06-02" version="1">MRTDRLVAVLLLLQRRGQVTAAEVARELEVAERTARRDLDALAMAGVPVYSVQGRGGGWRLVGGARTDLSGLTASEARALFLVAGPASAATPPVKAALRKLVHALPEPFRGEAEAAASSLVTDPNRWGSSRVGPRPPRFLDDLQDAVIRGVQVRLRYVDRAGAETERTVHPLGIVAKGPSWYLVAGTEAGRRTFRVDRVSAADPTGEPVHRPEDFDLAESWREIADEVDRRRMPLEIQAVCTPGGMGILRLALGGRLDVGGTTADGRIEVVIRGQDEYVVAGELSGLVEWVEVTGPPSVRDRLASIGTALVERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXK5</accession>
    <name>A0A7W7SXK5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="455" mass="49059" checksum="5694E2C349A97D1E" modified="2021-06-02" version="1">MPADFWLRPALADALHSRNIGRVFLAYRKSWNPWISQTRLAEWLDLTQGRISELERSRRAVTDLDRLERWCDVLRVPPRLRWFASRSDTANSGPEYAEGLPATVAVVAVLGRQDMERRAFLAGALFSVAASVGPSRDWLVATLDGTGAGRSVGGEQVAEIRRTFAVFQELDVMRGGGHAREQLSKYLTSQVVPLLRENDPASDSGRALFEAAAEQLYLLGWMGFDNGEHSSAQRYLVQALRLAEAAGSPELGAHVLAGLSDQATLTGHPDHGVQLARAGRVGLAQGHSNACAARLWALQAKAEGAMGDAGAVVRSVGQAEAAFGNIDLDDEPEWARFIDAAYVNGEFAHAFRDLACPEEATRYATVSATESERLNRARRGAMAQATLARAALDSHDLEAAATAGSTAVKLAATVTSTRSTAAIHDLRTRLMPHRAARVVREFFSLSTALLPAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXU0</accession>
    <name>A0A7W7SXU0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">F4559_000260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4962901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="20759" checksum="DB046EA34D7450D1" modified="2021-06-02" version="1">MPGRTRREGGGGERGERRDRRDGGRGGAAQEKTPHLERVVAINRVSKVVKGGRRFSFTALVVVGDGDGMVGVGYGKAKEVPAAIAKGVEEAKKNFFRVPRIAGTIPHPVQGEKAAGVVLLRPASAGTGVIAGGAVRAVLECAGVHDVLSKSLGSDNAINIVHATVEALKGLQRPEEVAARRGLPLEDVAPAGMLRARAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY06</accession>
    <name>A0A7W7SY06_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33128" checksum="03408A4A07F74A3E" modified="2021-06-02" version="1">MTVVVLGASRGIGHEIARQLAEAGRDVRAVSRSGGAPAGAEGVRADLLSRESTVRAAQGASVLHLAANVPYTEWTTTLPTMLDNAIAAAHDTGARLVFADNLYAYGPVSGPLRETTPEKPLGVKEKLRSALGATLRSSGVRYAIGRSSDYYGPGGVSSLVGELILRPMTAGRRPMWFGPLDVPHTFAYLGDTAAAQITLGDGDRDGTWHVPAAPTLTVRAFADLARKVIGSERTPLRLPEIALTVGALFEKRLRGAGELAHQRTRPWVVDHSAFETDFGPFAVTPHEEAIRRTAEWYRDLGVGAALSRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY53</accession>
    <name>A0A7W7SY53_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="432" mass="47361" checksum="5A053D6CDFE0A9F9" modified="2021-06-02" version="1">MTVRFSEAWSVAYEFADEVRRADRDVILVRDVVGRLSLIVGGEPDEDLPAAFTGRVGAFSSPNPVLYMADLFEPGVVLDSPDLHVRAERSDGVGRLATLDRSLVGADWSRPHTDTPGRNRTTLYGFKGGVGRSTATAMLADHLANLGECVLVVDLDLESPGVGALLQNEDGLPEHGVIDHLVEAAVDNEADLDLVSRSTLLGNHGNGEVWIAPAAGRVSPDDDYLGKLNRVYTDLPPTDDGTPRRFGDRLEAAIVACEEQVTKQSRRPSVVLLDSRAGIHDIAAAAITQLSDTSLLFAADNPQTWNGYGILFKQWQRHLPPEALDHIRRRLRMVASMVPPNNASNYLDLFRDHAQQCFAETLYDDAHPDDFEAFNFASDDRTAPHSPLPILFNSDLISFDPVRRDGWHTQPLIAAAYRPFLEEAATLLVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY94</accession>
    <name>A0A7W7SY94_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15340" checksum="10E5A3539FC57509" modified="2021-06-02" version="1">MRFTAGWTVHLPDSHRDGGEVRTIATAADVDALVVELGKDASEVAWIHHADRPLIPAPFTGEPGPDHILNAGIAYGYGYLGYLDPDHDFHHPVGDPASPVYHSDSEEFDAGSGIPVETLTSALKEFLATAQRPTCVDWTPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYA7</accession>
    <name>A0A7W7SYA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator MtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24823" checksum="8D3C646817F558B0" modified="2021-06-02" version="1">MKARVLVVDDDPALAEMLTIVLRGEGFDTAVVADGARALPALRELKPDLVLLDLMLPGMNGIDVCKAIRSESGVPIVMLTAKSDTVDVVLGLESGADDYVVKPFKPKELVARIRARLRRTEAEPAEVLQIGDLTIDVPGHEVLREGRPIQLTPLEFDLLVALARKPRQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVERDPEHPEVVLTVRGVGYKAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYC5</accession>
    <name>A0A7W7SYC5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="36032" checksum="D8A3D6E1E8A814E9" modified="2021-06-02" version="1">MRVLVTGGAGFIGSHYVRELVRGAYPAYADAEVVVLDKLTYAGNEANLAPVADDPRFSFVRGDICDRELVSGLMRGTDVVVHFAAESHVDRSIDGSADFVLTNVLGTQVLLQGALEAGVAKFVHVSTDEVYGSIDEGSWTEDHILEPNSPYSASKASSDLLARSFFRTHGLPVSITRCSNNYGPYQFPEKVIPLFVTNLVDGRNVPLYGDGLNVRDWLHVDDHCRGIQLVLEGGRAGEIYNIGGGTELTNRELTERLVAATGRDWSAVEPVQDRKGHDRRYSVDITKISTELGYAPKVDFATGLADTVEWYRSNRSWWEPLKQRAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYN9</accession>
    <name>A0A7W7SYN9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Act minimal PKS ketosynthase (KS/KS alpha)</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
            <ecNumber evidence="6">2.3.1.235</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000747</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EC" id="2.3.1.235" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="3"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="44155" checksum="70E9DD496CA2FDCD" modified="2021-06-02" version="1">MTAVVTGIGVVAPGGIGREPFWDLLVGGRTATRAITLFDAKDFRSRIAAECDFDPADHGLSPREIRRMDRAAQFAVVSAREAVEDSGRRIADVPPHRIGVSIGSAVGCTMALEREYVVLSDKGREWHIDHEYAVPHLYGHMVPSTLAVEVAWQAGAEGPVALISDGCTSGIDAIAHGARMITEGRADVVLAGATDAPLSPITSACFDAIRATSPRNDDAEHASRPFDADRDGFVLGEGAAVLVLEHKDAAQARGARIYGEVLGFAARSNAFHMTGLKPDGREMAEAIDAALAEARRDPRAVDYVNAHGSGTKQNDRHETAAFKRSLGHHAYRVPVSSIKSMVGHSLGAIGAIEVAACALALDRQVVPPTANLRTRDPECDLDYVPSTARDHRVDTVLSVASGFGGFQSAMVLGRGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ61</accession>
    <name>A0A7W7SZ61_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="190"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="373" mass="40462" checksum="845EB48EE7B36230" modified="2021-06-02" version="1">MVKAVHFVASVGDSYGGVATAVAGLGAVERHLGHVPSLVTLDRPEQGTDTLRRAVRAFDVHLLVPHRFTGRFHHGRDLTATARALVAEHDVVVVHGVFDAVAQAGWLAARAAGKPYLVWPHGSLDAYDLRRHRLAKFALAPLWRAMLNGARAVVCTTRREAERVRRFGATTATTVVPLTTGGPPVIPRQAARDEYRTVLYLGRIDHKKGLPLLLEAFDRAAAPGDELVIAGSGDEELESALRRRAALILGDRTVYFPGWVDGVTRRALFTRADVFALLSDNENFGLSVAEAVESGVPALLSDQVYLGDELVEHEAAVVCERTVESAATSLRRLLDDADLRRRVGHNGQVYARDRFAVPAVADAYLSLLGGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ80</accession>
    <name>A0A7W7SZ80_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">F4559_000924</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="356"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MBB4963565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="435" mass="44883" checksum="F3C9756251DF96F5" modified="2021-06-02" version="1">MPGHKQHGPIRVALLGCGTVGTEVVRLLTEQADDLTARVGAPIELAGIAVRKPNKHREVPADLLTTDAEALVASDVDVVIEVIGGIEPTRTLLRKALEGGKSVVTANKALLAEHSAELFEAADASGADLYFEAAVAGAIPLLRPLRESLAGDRITRVMGIVNGTTNFILSGMTSTGSSYAETLEEATRLGYAEADPTADVDGYDAASKAAILASLAFHSRVTASDVHREGIASVSAADIAAAKGLGRVVKLLAICERVEVDGTESIAVRVHPAMIPVAHPLASVNGAFNAVFVEADAAGEMMFYGQGAGGAPTASAVLGDLVAAARNRVGGGHGPRESAYAALPVRPMGQTPTRYHISLDVADRPGVLSQVAAVFAEHDVSIAAVRQEGRVDDAGLVVVTHAATDAALRSTVDKISGLPVVREVVSVMRVEGEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZH9</accession>
    <name>A0A7W7SZH9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="476" mass="52803" checksum="C6B8F215A36C2DE1" modified="2021-06-02" version="1">MKLSDLTPEEWYARLTTKTLHQRRTALKWWQYMNLEQELVYVARIIAEQDDRFPPLLLPWAELVVESVIERLRLESFLSGEAPVDALVKSWNDNDLAVNSDEAHKASSVSGLHFLMVGPDGAGGSPMVTTEYCDQVAVELDPRTRQPLVGLKLWTEDLDGFGEGHAALYIPEVPTLTQRRPGRCRVFELDENGALFETEPLGDWSRVIAEDPSLPSVPFVPMLTNPVRGHGTSDLLQLKPTLDGANQIATNMMAAVEHHAVGRKWVVGASEKDFVDENGNQIPLWRIAMGDVWAIPHAKQEQRNEKPPETKVGQFAASDLRNFHESLKTLAQVAASKYGLPPLYMGYSSDNPASAEAIQFSLERLVLRAEKRQLWYGGAWERAGRIQWAILGKDPTEISGMESKWRNAATPTMASKMDAAVKAVGGPVIDQEQAWNDIGYSEAAKAGMRERMRLRGVTAAQSLRDLDATATPRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT7</accession>
    <name>A0A7W7SZT7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="8" type="ORF">F4559_001313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="7">
        <location>
            <begin position="67"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29184" checksum="73A5F18D8EE681BA" modified="2021-06-02" version="1">MANYTAADVKRLRELTAAGMMDCKKALEETDGDFDKAVEILRIKGAKDVDKRAARTTSNGLVAAEDGVVVELRCETDFVAKNSDFQDLAARIVAVAKATRPADAEALKAADLDGRTVDAVVQELSAKIGEKLELAKVAVFDGKVTTYLHRRAADLPPAVGVVVEYTGDSEDAARGAAMQIAAMRPRYLTRDEVPADVVANERRIAEETSREEGKPEAALPKIVEGRVNGFFKDVVLLEQSSVTESKKSVKAVLDEAGVTVTRFARFEVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX0</accession>
    <name>A0A7W7SZX0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR02118 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02118">
        <property type="entry name" value="TIGR02118"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EthD" evidence="1">
        <location>
            <begin position="127"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="26491" checksum="7300A627205C5A0B" modified="2021-06-02" version="1">MIHQLIFAYPRPGLDEDEFHRYWVEEHAVRYAAKIPQIRQYCVDTRVELSADEPAPTWSGVAEIWLANEEEQLASLQTPEFLEGARIDEPRWAAFWRTLVLDTDAHVVFDRPDAEPGVKLFVLVKRREGMPLTEFRQYSRDAHASLMGKVPGLRRYHQNHTRDGAYGIGEAPLDCAYQLWFDDVAAVRDAVRGNEFQRAMADLATFTNPRYVHTLAVRENWIIGPRPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T044</accession>
    <name>A0A7W7T044_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="224" mass="24266" checksum="EC2343A9180FEE5F" modified="2021-06-02" version="1">MRLPLFPLGTVLLPGAALPLHVFEPRYRQLTVDLLSGEVPDRTFGVVAIRQGWEVGADGAESLHEVGCSAVLDDARRLPDGRFDLDTTGGRRFRLLDVDDTAAPYRIGEIEWLPDTAEPPGMADVLPRLVDSARAAHGRYRAAAGDHPSRGGPDAAIPPHELAYALAADCVLTAEDRQLLLEETSASRRLRLVRTVLHREAGILTALNAIPAPLSELGHLPHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K5</accession>
    <name>A0A7W7T1K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid degradation operon negative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30652" checksum="157C221019140F60" modified="2021-06-02" version="1">MDVEVPTRTVVEALVRPDGTVDAGELYEVANALGMSDQQVRLCLKRLVAEGRFTQEGRGRRAVLRAASREAGLDVEFVRFMYRQDAGEEEWDGVWHLVAFAVPESRRRERDALRDAIVRFGGAALHGGLYASPHAWEDLVEGEASAWDVDSCVTFLTSTDLRVGGERDPVALAARLWPLDAIADRHRLLAAVAAHRLRLLRSGDLDRAGLLRVAVELAAEFTRAVEPDPLLPPELLPSPWVGTRARAAVARCWSALAERADDLPALFVAYRGIGEKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T273</accession>
    <name>A0A7W7T273_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="33149" checksum="41E387CA6C00FB05" modified="2021-06-02" version="1">MSPHPQQPAVEVSGLVKRYGSNVAVDGLDLTLDRGTVLALLGPNGAGKTTTVEVCEGFRAADGGSVRVLGLDPRRDGDALRARIGVMPQGGGGYPGVRPDELLRLVAACAANPLDPAWLLDVLGLDSARRTTYKRLSGGQKQRLSLACALVGRPELVFLDEPTAGMDPQARRLVWDLVGALREDGVSVLLTTHLMDEAEALADHVVIVDSGKVVAAGTPASLTRGTGDEQQLRFKAKPGLELSLLRDALPEGLDVRETLRGAYLIEGHIDPQVVSTVTSWCAQQGVLAEELTVAKRSLEDVFLDLTGRELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C2</accession>
    <name>A0A7W7T2C2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19080" checksum="4CD984026F421120" modified="2021-06-02" version="1">MAHEGDGDPDPTVVLDRNREQQATVYGESLGVLFGRLGTQLGLTQARIGGLLGLSAPMISQLASGRRVKIGNPMAVQRLQSLVDLGFKVTSGEVPAADVEARLADIAGQGAVVTKGVQTGGTPSARAAARAVQSLLRAVAGAEELLDAASMIEARHPDIAAVLRVYGAGRTGDAVEHYAANVDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H7</accession>
    <name>A0A7W7T2H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding SARP family transcriptional activator/DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="4">
        <location>
            <begin position="1117"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1186" mass="126785" checksum="D738519D3118B315" modified="2021-06-02" version="1">MPAGLRVSVLGPVRAWSGDTELALGHARRRAVFAVLVARANQVVSRQELVDAVWGEAPPARVVGSLHTYVSGLRRVLGPHREALESRPHGYSLRLADDAADTARFDRARDHGGRLSAAGRWAEARDAFEDALGLWHGSAYAGLPGPFAERERHRLAELRLGVAERRARARLELGEHAEVVADLAELVAEHPWHESLRELVMVALHRSGRRAEALEAFQDARRALVAGQGVEPGPALRELHRDILAGPSGPLFSAPGVTPGGVFVGRDDDTAQLRELVSDVLAGRGTAVWVEGEAGIGKSALLAAALADAGDRGCQVAWAVADELGRRNPLRVVLDCLAVHPESPDPRRADLAARLRGDPDPIDVPAAVDRLAALVDQACATAPLVLVIDDLHWADDASVLLWHRLAAATRQLPLLLVAATRPDPARRELARVRRAVEAHNGYVLALGPLTTADAEALLARTVGAPAGEGLREVIGFAAGNPLYLTEVAHALVRGSAVRVVGGVAEVDPDAAERVPRSLSAAVERTLDLLSAETREVLRLAALLGARFRVAELTAVTGRSPLELVCVLDEAVAAAVVVEAGDDLAFRHPYLRQVLHEDVPRPMRVALHRHAAEALAGTGVPVERVAGHLVAEEIPADGWVVRWLADHHAAVAARAPGAAAELLRRAVDTDLPTPAQRACLLTALVRARFRVGRFPEADAERALALTTDPDQAAELRHLRAAMRHRRGDPATAITLLGEALDAPDVPESWRLRHVALLADFQRGDLDDLDRTRLSAERARARAVDAHPAARAAQTLWLVRSIRRDHGRALRHVDDALAVVGDRPGLAELRFDLLDNRVFSLQNLDRLDEAERALRGVPDPPTCLQVTAAVHHHWTGRWDEALAGLDALAEDGTGLFGLREPGPTTLLVHGVAALIAGHRDDRVAATAHLTAAREHTAATRAERENCDFHLAAEALAAEQRGDVVGALAHLAPALRPDYAPMMLRHQWLPLVIRLALTVDDHATARTALAVCEEEAAKEVVPARAHAAAAHCRGLLADDPDPVLEAAAHYRSVGRVVECATALEDAGVLLAAAGRADEASSAFAEAVESFGALSARWDVHRAESRRRAAGVVHHPGHPPAKSGWQALSPLEVRIARLVAAGLSNPDIAGELALPRRTVQSHVARLTAKLRTDSRAGITGHVHANSPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K7</accession>
    <name>A0A7W7T2K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13514" checksum="A2639362AA1F3577" modified="2021-06-02" version="1">MTPEGTTGPQVPQAQTTAERFDDEDYPAYTMGRAAEMLGTSAGFLRSLDEAKLIEPQRSAGGHRRYSRSQLRLAARVRELVDQGTGLDAACRIVTLEDQLQEARDANRPQHPPGEPYPPLHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N6</accession>
    <name>A0A7W7T2N6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative intracellular protease/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="29"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24771" checksum="0D83A6D56FE74C83" modified="2021-06-02" version="1">MSRPRILVTMSSHADLGVSGKKTGTWFEEVATPYYVFTEAGFEVVFASPLGGEAPIDHLSLQAPFTTANTDRFLDDPAGMRAVRHTNVLADVDHRDFDALFFPGGYGLLWDLAADSRVIRMVEHALATGTPVAMVCHAPGILRDVKSPDGTPYVAGRTVTGFSNTEDDELDLSRHLLFSLEDDLVLRGADFTRSTANWQPHVVEDGPLLTGQNPASAPVIAKALVDHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2P7</accession>
    <name>A0A7W7T2P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="57">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="57" type="ORF">F4559_002842</name>
    </gene>
    <organism evidence="57 58">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="57 58" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="57 58">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="54">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2E)-butenoyl-[ACP] + H(+) + NADPH = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>(2E)-decenoyl-[ACP] + H(+) + NADPH = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>(2E)-dodecenoyl-[ACP] + H(+) + NADPH = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-hexadecenoyl-[ACP] + H(+) + NADPH = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(2E)-hexenoyl-[ACP] + H(+) + NADPH = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(2E)-octadecenoyl-[ACP] + H(+) + NADPH = NADP(+) + octadecanoyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>(2E)-octenoyl-[ACP] + H(+) + NADPH = NADP(+) + octanoyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(2E)-tetradecenoyl-[ACP] + H(+) + NADPH = NADP(+) + tetradecanoyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>3-oxobutanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>3-oxodecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="51">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>3-oxododecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>3-oxohexadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-oxohexanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>3-oxooctadecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>3-oxooctanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>3-oxotetradecanoyl-[ACP] + H(+) + NADPH = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>H(+) + hexadecanoyl-[ACP] + malonyl-[ACP] = 3-oxooctadecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>H(+) + hexanoyl-[ACP] + malonyl-[ACP] = 3-oxooctanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>H(+) + malonyl-[ACP] + octanoyl-[ACP] = 3-oxodecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>H(+) + malonyl-[ACP] + tetradecanoyl-[ACP] = 3-oxohexadecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>H2O + hexadecanoyl-[ACP] = H(+) + hexadecanoate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>H2O + tetradecanoyl-[ACP] = H(+) + holo-[ACP] + tetradecanoate</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:14993"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:14994"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>butanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxohexanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>decanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxododecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dodecanoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxotetradecanoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="57">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="4 55" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="58" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="7 57" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="56">
        <location>
            <begin position="1840"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="56">
        <location>
            <begin position="3718"/>
            <end position="3794"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="56">
        <location>
            <begin position="5308"/>
            <end position="5383"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="55">
        <location>
            <position position="1875"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="55">
        <location>
            <position position="3754"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="55">
        <location>
            <position position="5343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00023385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00023387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00023389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00023390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00023396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00023397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00023403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00023410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00023413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="49">
        <source>
            <dbReference type="ARBA" id="ARBA00023414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="50">
        <source>
            <dbReference type="ARBA" id="ARBA00023416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="51">
        <source>
            <dbReference type="ARBA" id="ARBA00023418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="52">
        <source>
            <dbReference type="ARBA" id="ARBA00023419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="53">
        <source>
            <dbReference type="ARBA" id="ARBA00023420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="54">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="55">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="56">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="57">
        <source>
            <dbReference type="EMBL" id="MBB4965483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="58">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="5650" mass="590306" checksum="C9AC1769010B488F" modified="2021-06-02" version="1">[encoded data, 5650 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R0</accession>
    <name>A0A7W7T2R0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="500" mass="52105" checksum="B8522E3057C9D66E" modified="2021-06-02" version="1">MTSLPDRTHSRAVLIGTSDFKRADHFPPLPAVRNNLFDLMCALTAADTGILGWQQCVLVDTPDTVSSFMERLRKTAHQAEDLLVVYYAGHGVRHDVRDELYLTVRDSDRDGLAGTAVPFDFVREVLADSPARVKLLILDCCYSGTALGAMSAGGIGARDIAVAGTTVITSSAPNRVSLASEGHRNTAFTSELIDILTRGASLASAPLTINTLYRSLLAATANHGIPEPRFKSTGTSADLLLRGDRPPVPEPVAVPVAAATPAQVPPAPVANAPIPTAVVPPPAPVAWPENPRPLEYRPMSPLFAGAAVGPPSVPPVRPAPSARGAASGVSRVVSGLLLIPLWLGVIFGVAGTLAGVVGFLFGTPPPGKTTAGDLAGGAASLMIGVCCAVLLRWPVARWRAGRSPVPARLALRVVLLRPLSRIPPAVSVIVLAMTAPTTVAMAVGRWTTSPTSSGSALGSAVFGTGIMLLVSVLFALSIRCRRKRAQAAQRCPKWTLPGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R1</accession>
    <name>A0A7W7T2R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="455" mass="48204" checksum="6C8C5BFAE3797D69" modified="2021-06-02" version="1">MPDLVFPADPAYALSRNRFIGRPDEVLPRAVARCADVEDVRAALALAREEGWSFALRSGGHSNAGHSSTTGLSIDLTPLDTVEVHGDRVTIGGGVRSGRLARVLAGHGRLVPLGSCPSVGVVGAALGGGFGCDGREFGLTCDALVAAQVVLADGRVVEASGDDDLFWALRGAGGGHFGVVTAATFAAVPARPRTHLVLEWDFRYASALVSWWQRILPDAPDPVSVELQLVVPEDTDADPVALLVGAVPDRAAVDALVADFGVPPRRSEIVDLDAAQAVVCRPTPHSAAAVDPERDPLTHHRPGMMTCRTAFFADPLPDDATAALLAHLTGEREFGESRELSFTPWRGAYGRVPVAATAFAHRDAAFLLKHSVLLGPGGAQRRGAAVLDRITAGWEIARPHGTGGVYPNFPDPAHADWPTAYHGANLARLRAVKARFDPEEVFRHAQSIRPRVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T346</accession>
    <name>A0A7W7T346_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein YiiM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8315" checksum="20AFEB9FCCFA9BA5" modified="2021-06-02" version="1">MGAHVHRAGVPGAYLRVLEPGEVCAGDVVESLHRPGHGVTVALAFRAFTTEPDLLAELPVPDALAADLAAKAHRLRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T388</accession>
    <name>A0A7W7T388_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030814963" evidence="1">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15721" checksum="BB37998B75C3AF1E" modified="2021-06-02" version="1">MSFFGTIGATVAAVACAAVTVTSPASAEPSAAVSRSTSGGASTSAAADCPVDRYGYRGYALCGTRVLDVDWGNRRYETFVVGTNREVWHAWPGSGGWKSMHGWAYDMKDARWEGKARVVEHKGRDNRSWCHKDPGTGKWSGTYFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N8</accession>
    <name>A0A7W7T3N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Excinuclease UvrABC ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="5"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="446"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="486"/>
            <end position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="753" mass="80338" checksum="9F2B57C844B347F7" modified="2021-06-02" version="1">MGTIADSHDVIEVRGARENNLADVSVDIPKRRLTVFTGVSGSGKSSLVFGTIAAESQRLINETYTAFVQSFMPSLGRPDVDALRNLSAAIVVDQERMGANSRSTVGTATDAHTMLRIVFSRLGTPHVGTSGAFSFNLPEGMCPECEGLGRVSTIDVDELVDRTKSLNEGAITVPGFTVDNWYVQTYIQSGFFDPDKKLADFTDDEWDAFLHRESTKVKVGKNNVTYEGLVVKVNRLMLAKDRESMQAHVRTFVDRAVTFTTCPSCAGARLNDAALSSRIDGLNIAECSAMQISDLAAWVDKISDPSVAPVLTTLGELLDSLVGIGLGYLSLDRQSGTLSGGEAQRVKMVRHLGSALTDVTYVFDEPTVGLHPHDIRRMNDLLLQLRDKGNTVLVVEHKPETIAIADHVVDLGPGAGTNGGRICFTGTVDALRASDTLTGRHLDHRARLRDTVRTPTGTLAITGATLHNLRDVSVDLPTGVLTVVTGVAGSGKSSLIKGSLAGRPDVVLVDQSPIRGSRRSNPATYTGLLDPIRAAFAKANGVKPALFSANSAGACQKCKGIGLVYTDLAMMAGVATVCEECAGKRFTAEVLAYKLRGRDISEVLAMPVAQAREFLIEKQAAAILDRLVDVGLGYLGLGQPLTTLSGGERQRLKLAIHMAEKSATYVLDEPTTGLHLADVDQLLALLDRLVDAGNTVVVIEHHQAVMAHADWIVDLGPGAGHDGGRIVFTGTPEDLVSSAGTLTARHLRKYVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P9</accession>
    <name>A0A7W7T3P9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="13" type="ORF">F4559_003358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="8"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="11">
        <location>
            <begin position="408"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="491"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4965999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="729" mass="78603" checksum="F29047B9B20D9723" modified="2021-06-02" version="1">MTSGIGATVLGYPRIGPRRELKRAVESYWAGRSDADTLHAAARDLRVATWLELRDAGLDSVPSNTFSFYDQVLDTAFLVGAVPDRYRRSSALDTYFAAARGDADAPPLELTKWFDTNYHYLVPEIDSSTEFRLADDKPLAEYREARAAGVPTRPVLLGPVTFLLLAKGSADPLSRLDALLDVYVELLGALAAEGVEWVQFDEPAFAMDRDVAELAALGRAYTRLGAVAARPKLLVTGYYGSLGAALPVLAATAVEAIGVDLVAGTIEGIASVPALRDKTLVAGVVDGRNVWRTDLRKAVATAASLLGSAAEVVVSTSSTLLHVPYDLDVETSLAPEVSARLAFARQKVAEVVTLDRALRSGVPLPELPVVEPRRDEEVRFRLAGVKDRSRAPYAARVVAQKALNLPPLATTTIGSFPQTAEIRAARSLPSDEYTARMRAEIARVIALQEDIGLDVLVHGEPERNDMVQYFAEHLEGFATTRLGWVQSYGSRCVRPPILHGDVSRPAPITVPWTAYAQSLTSRPVKGMLTGPVTILAWSFVRDDQPLGETADQVALALRDEIADLEAAGTRIVQVDEPALRELLPLRAVDHPAYLEWSVDAFRLATSGASARTQVHTHLCYSEFGEVISAIDGLGADVTTIEAARSKMEILDDLRASGFSRGVGPGVYDIHSPRVPAVGELTELIKAALAVVPGDRLWVNPDCGLKTRAYAEVEPALRAMVAAAREVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3X3</accession>
    <name>A0A7W7T3X3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN family beta-propeller protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030593200" evidence="1">
        <location>
            <begin position="22"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="33554" checksum="2960FDB6B76D8DB9" modified="2021-06-02" version="1">MRRLIVLVVLLMAATPTTAVAGGHRKPVVIATIDVGLAPRAVTFTPDQRYAYVANAGSNTVSVLDVDKRAVVDTIPVGSFPYGIAFDRHDHAYVANRDSDEVTVVDTDSRTAVKTIPVGDAPRWAEVTPNGREVYVSSTGSNAVTVIDTRTQAVTATIPVGKAPRGIEFDRAGRHAYVADSDSDTLSVVDTRTRAVVATVPVGDEPRGVLVTPDDRTAYVSNTIGGTVSVVDLRTRKVTTTITVGRNPRGISLHAGNRIAYVANSGSGTVNTIDTRTNTVVGEVAVGTDPRWTAPGPGHRYVLVTNTGSASVSIVTLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T439</accession>
    <name>A0A7W7T439_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030753225" evidence="7">
        <location>
            <begin position="35"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="150"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="398" mass="40439" checksum="3BED87D4AF1F7924" modified="2021-06-02" version="1">MGIRTVGVTKVGTAVAALAATFAAVTIGAAPAQAAEGEVVGLGAADSIRDSFVVLLKNGRGAEQRTAGDLAGRFAGKVDHVYSGGVSGFAVTLSERNAKRLAADPAVALVEQNRTVRADGVQTNPPSWGLDRVDQRKLPLDNKFSYANTGRGVNVYVLDTGIRASHQDFGGRVRQGYDFIDNDTDGDDGYGHGTHVAATIAGTKYGVAKEALLYPVRVLGSDGSGTTAGVIAGIDWITANAKKPAVANASLGGGASTAVDTAVRKSITAGITWTIAAGNSNQNASSTSPARVTEAITVAAADKTDARASFSNYGSVVDLFAPGVGITSAWKDNDTATYTGNGTSFAAPHVAGAAASYLSTHTSATPAQVQKALIDSSTPNLVKNPGSGTPNRTLYLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F5</accession>
    <name>A0A7W7T4F5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine catabolism regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="461"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="529" mass="56112" checksum="998F671437277C13" modified="2021-06-02" version="1">MYPTVADVLATPAVQAGDPRVRAGEEHLDRPVRWVHVSEISQVAGTLSGGELLLSTGIVAGDPDVDLSAYVTRLHEAGVSGLVVELGAELPALPHDLVRAARTLGLPLVELRRTVRFVEITEAVHARILDVGHERLRFTQRVNDVFTTLTVEGARVEEVMDQVSALGGHPVVLEDLSHHAVAFSGTTRAGELLRDWESRSRLAVAGGETAVAGPERWLCTPVGPRRGRWGRLVVPMTVADVERSSAVLERAAAALAILRVVNGEGRDVALDAHGGILRDLLTGQITDEQSVGARLRALGLRAGRAYAVIVFAVGVPGPPSAAADQSTVDVVAATARGQGRSALTGVVAPGRIAVVFPCSGEDDEPAAVRSFLAALDGRLPTGTVAAAAVPPTRITGLSAALEEAVHVAEAVAGEPGERIVYRSRDLGARGLLWSLRSDVRLHQFTESQLQPLLGHRGREGLLDLLRAFLEAHGNVAVLARELHLSRPAVYARLGRLTDVLGRDLADAQTRLSLHLALLAYDQAARHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I8</accession>
    <name>A0A7W7T4I8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="48749" checksum="21E703628EC798DB" modified="2021-06-02" version="1">MTDPQPSTPPPSTPALRRGLKVLGTLLITLSAISPASSVFIIAPGVVAQAGSGAFWSFAIAGVVGVFMAFVYAELASAYPLSGGEYAIVARTLGRLPGFVTLGLLLLTQLLIIAVIALGVGTYLEVLIPGLSAPVVAAVTTVAATLLSIFDIKVNAWITGVFLAIEMVALVVVAALGFLDPARGLGDLVTAPVVATEGVVGPASFGIIAGAAAVAIFSYNGYGSAVYFGEETDNAHKGIARAILWALGITIVAELVPVTAVLLGAPSLPDLFGAENMMSYFVGAKAGSTVNTVISLAIALAILNAVLAIILITSRMVFSTGRDSAWPASVSKALAAIHPKTGTPWIATLATGAFGTALCFADKDFLLVVTATSIVAVYVALCLAVLNGRRNGSTKHAAYRMPLFPVAPIVALIALGYVVWQNALDPAFGRPSLLITAGICVVSGLYYALVLRRRGKWELQGPSEDEAEVDTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V0</accession>
    <name>A0A7W7T4V0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="618"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="843" mass="89648" checksum="7DC2194AF303869A" modified="2021-06-02" version="1">MKTKRGELRIYLGAAPGVGKTFAMLGEAHRRRERGTDVVVGLVETHGREKTAALLDGLDRLPTRVVPYRDHEFAELDLDALLARAPEVVVVDELAHTNTPGSANAKRWQDVERLLDAGIDVLSTLNVQHIESLNDVVERITGVRQRETVPDEVVRRAGQVELVDLTPEALRRRLAHGNIYPAHRVDAALADYFRIGNLTALRELALLWVADQVDVALRRHRAEQDITDTWETRERVVVAITGGAESETLIRRGRRIAVRAGADLSVVHVLRGDGLSGVAPDRVSVFRKVAEGVGATFHTVVGDDVPSALLEFARGVDATQLVLGTSRRSRVARVFDEGIGAAVIGASGSIDVHMVTHDESTRRPRLDARSTSLTPRRRLSGWALGVLLPAAVTAIGWAGRDDVAASTDLVAFFLATVVTALVGGLGPALVAATLGAGLLNYFFTPPLFSLTVATPENLVTLIAMVVVAVLVALVVDRAARLAEQGARARTEAALLASYARIVLTGPAPLDRLLDQVRENFGLESAALLERRDGAWELVASAGGTPCREPEKADVDVRVTDDVHLALRGRTLPARDRRVLEAAAGQALSALRQQRMAAQTEAARRRAETTELRTALLSAVGHDLRTPLTSIKAAIGSLRSPDITLSEADTAELLEAVEISADRLTALVDNLLDSSRLATGAVAPLLRPVTYDEITARALAGIDDRHAVTVEVAENLPAVLADAGLLERVVANVVDNALRHGRSRGPRADGEPGIAVRASAHGSRAELRVVDHGPGVPKDTAAAVFAPFQRLGDRDATPGVGLGLSVAKGFVDAMGGSITAEDTPGGGLTIVVSLPTADATPSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T526</accession>
    <name>A0A7W7T526_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="9168" checksum="4D97F5E985511099" modified="2021-06-02" version="1">MIVIEDEEFWTRFDGEVRVNWEASNLRQFSSLDAEQVEALVNDVAWSNEGLFALLQGLRRLRDIGGSRVNLPTIEWETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T572</accession>
    <name>A0A7W7T572_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="32" mass="3495" checksum="3B938A27DC28C999" modified="2021-06-02" version="1">MTSSHASPDRAELDDQPYGDLIHRVRAATGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T573</accession>
    <name>A0A7W7T573_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="33537" checksum="E1E9CB128A91D6D3" modified="2021-06-02" version="1">MRVHQSGPSRSTGDLVPGQSWDANHRLVGQALLTGGRQVAHRRYHYQADDSLVAIHDSAGPSRNYRVDPLGRVTGVDGPGWRERYAYDAAGDVTASDTAHAGTLVRTSGDARYEHDAQGRVVPRQRKRLSANPIPGTTGGTPTTASSRSPHRTAPTGPTGTTRWGTAWSDALGLTESRDIEFLDPGDINFSQRSVTRNDYAMRNGQWDRNRSPVHVMEIDGQLVSYDDRRLDAAREAGVPVGVQRVDPTAPHPESTTGKTWAEKFQERFRDPLTRLNGEPVPDTGPNERPTALPPGCGGGRRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K5</accession>
    <name>A0A7W7T5K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="433" mass="44766" checksum="93467E74AE6418B2" modified="2021-06-02" version="1">MSGRLRSSLVIGGQGIRARKLRTFLSMISLFLGVLAVVVVQAGSEIANQLMLADVEKSSGKDGTRVLYLPPGEDFVPIALDLLSGRTDAAAMTTVTAIVGEPGVKAINDGGGPIDQPAYGRGGGMYCDETGCHPVTDGTAGMPSGQAIELELKGLSGDIRPFRPLHPTQGKWLEFGTEPSLSPGLVLNLEAAKAFSRYQVPARLRITGATTDATPRIVGVVDDGGYTPAAYVRIDELLNWMPPNAVGGSRGGPGVEVMFTPTAGETERLLTSRLAAAGAPAEQLSVRTVDVLERMKSQLALMRWIFLGMASLVLLIGVAGILNVGLATVGERIEEFALRRAVGTSRMLLAGIVLAETMITGLLTAGAAIGVSAAALPVAVGLVADKYPALSDMPFPWQAAVAGIVAGVAAGVLGGLIPALRAARIPIATVMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L0</accession>
    <name>A0A7W7T5L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Soluble lytic murein transglycosylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="173"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="27947" checksum="1ED7764FC1AF9604" modified="2021-06-02" version="1">MARHTKATGRTVYTAAVAPEGYRGAHRAEPERAGLASRVAAVAVAVGAVTGSGAAAAATMGPFNPLAGAADFGGLPDEPKTIEYSGKVDTVHAIDLGSETARMLKGEQLAALDAYTQASGVASSGYTARQEAAAKKAAEEAEARKSPHQRQVEGWIKEAIKVLQANGTPIDESAVDEIYTIIEKESNGNPDAINNWDSNAARGTPSKGLMQVIDPTFQSYKLAGHDDIYDPVDNIIAGVRYTYARYGGFHNHPGLVGIANGNGYQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T622</accession>
    <name>A0A7W7T622_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="177"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27509" checksum="A1C830D517790A1A" modified="2021-06-02" version="1">MPYALTEDGISVHYDVRGTGDPLLLIAGQSNSRHWWDWVRPYFAESFTTIAFDHRGTGASDKPEGDYSTVMFAEDARAVLDDLGVGRAHVYGTSMGGRAAQWLAALHPSRVERLVLGCTSPGGPHGFERGPEVRKALAQPDRGKALQALIDLMYTPGWNGPYSTVGDPDMPPYARRAHLLASAAHNGWDALAAIKAPTLVVHGSDDEFNPTANAPLIADRVPDSRLHLIEGARHAYFEEFHGEAGPLVADFLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T663</accession>
    <name>A0A7W7T663_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="724"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="805"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1060" mass="113651" checksum="6C0CE379840C7CBA" modified="2021-06-02" version="1">MEFRILGPFEVHGATGRARLGGAKQTALLATLAVRANRLTTVDHVVESTWADSPPVGVTAAVHTYVSRLRRAFDAVEDDGGARIVTRPTGYLLRLAPDELDLDVFRRHVARGREAAAAGRSGEASAELTAGLRLWRGPALVDVLSELIQRTEVPRLTEEMLGALGRRIDADLALGRHVDLIGELRALTVEHPLREQFSGQLMLALYRDGRQAEALDVYREVRDRRVDQLGIDPGPELRRLHQAILSEDPELAGPRRPAAVARPSMPPPMQLPADLVGLVGRAGIADAVAGELSSGADRNAIPIAVLSGLPGVGKTALATHVAHRLRKDFPDGQLHVNLRGYAQAEPVTPTRVLARFLRSLGLSPDLVPLDVDEQAAAYRSLLADKQVLVVLDNANAAEQVRPLLPAAPGCAVLITSRDPLAGLAVREGAVRFDLDVLPARDAVALIASVVGVTVVDSDPEAVAELVDLCGHLPLALRIAAANLSARTPATVRDYVDLLRDGNRMAALAVANDEQTGVRAAFDLSYESLSPSAARLFRMTALVPGLDFTAYTAAALADTTPDEAGRLLDTLVTAGLVQEAGPAHFQLHDLVRYYAAQRGRVEDAATTRDAAVDRLYAHYFRAACAASALIEPIRRPPEPPARLPDVPFPEPADRAAATAWFEQEYPNLHAAVDHAAEHGPRHHTWHLADAMSSPLALAPRFGEWVTVTRTGLRAARYEGDLSGEAIMLVSLGHAYSSTGRMGDAIDALEQALALYQRLDRPVYQQPCHHTLGMSFLWTGRLLKACEHFDRTIELTANGDDGGYYRAGAQHGLGIAYRYLGRLPEALDLLTAAVPVEPPPDESYVQTAWRFTLGLTYRDLDRYAEATTQLTAALAAYERIGNAFGTSRCLVALSGVRLACGDAAEAADAARRGLELSRQVKHRRTEVDALNALGLLSTARGALDEATAHHRQARTIAGAMGPYLYGVIEAEIGLADAATDPATARGHVHTALKSIQDSGFLLHEPGARLTAARVELAAGDRLTAVEHAERALTVALDTGRPLRADRARALLADTAGDRTAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C9</accession>
    <name>A0A7W7T6C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein YeiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="220"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="41751" checksum="22724BDCB24AD17D" modified="2021-06-02" version="1">MSLTTASPGPLAARERVLGPDLARGLMLALIALANSVYYLHGRPYGSRQHIVEEGILDRIVSVLDVAAVDARAYPMFAALYAYGVVRIFQRQKAAGRSDQEAKKLLRRRSRWLIVFGFVHATLLFPGDVLGLYGLAGFVLVALTRVSNRALIVIAGLWLVPVAVIQGGAAMMPPTGQREYFFSFETESLTKALALHPVEWLMVPIGMVGVWSALLIGTWAARRGVLTDPAAHRPLLVRTAAIGLPVAVLGGLPAGLGVGRFWSPTTVDGLWAVSALHAVTGIAGGLGYAALIGLIALRIGERRGPVVRALVATGQRSMTCYLFQSVVFVALLSPYTLGLGAKLGTAEVGALALATWLVSVVIADLLRRADRRGPADALLRRLTYRRGKIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K2</accession>
    <name>A0A7W7T6K2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18647" checksum="9B34BEF3C5998EE3" modified="2021-06-02" version="1">MTITVPYDERLFKRTTQFLLRPQLNRLYVLGAVLVALGVAMLTLTTIDKVVGVVCVILGPLLVFRIGRVTAAQALEAQWSATRAAFNLVIDDQWVSIAYPLAQMRCHWETLARVVEKPDVWYLMFTKSQAVPLPKNLMTPEQQAKFAALAAARTSVVPLRRAPAQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S3</accession>
    <name>A0A7W7T6S3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031264344" evidence="2">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="16472" checksum="E018A52470052607" modified="2021-06-02" version="1">MRSLGTAIGAGALLVALAGCATSQPSVEPAAGPALTTERPSPTPAPDQPTFDSPVPEGGKEVPPAKVDAALLPEQLPRTVWTEGDGSVLGVIGQEGGCSKASVEVAEQTSTKVKLVLVETVPKEEKMCTMDIRFPPLTAKIDAPLGDRQVVLAHRQDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T779</accession>
    <name>A0A7W7T779_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="29900" checksum="0697101465B93BF2" modified="2021-06-02" version="1">MADDFDSLREDPDPVRRGKRATDLLAVYQQRSAELARLRRAAIEEARDLLGGSYTEVAKAFGLTKGRITQIRSSAPPEHRAFFGVGPLDLALPGRLIRERDALLIASEDDAAGLQLSAQADKLAFIVNRVVLDPREEWEPAGDAIVVCGPTSAHIGHRLMGDDPCLRMAIGDNGQWHIVDQDTGQWYLSPLDEEAPVRADHAYIARHRWGSRVIVHIAGLHALGSIGAAHYITNAAADLFADFGDTEFSMAVTTEFDGLVPKAPKVLVPPRAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G6</accession>
    <name>A0A7W7T7G6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Crotonobetainyl-CoA:carnitine CoA-transferase CaiB-like acyl-CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="384" mass="41092" checksum="859A8CD0015C9725" modified="2021-06-02" version="1">MRPLDGLVVVSLEQAVAVPYATRLLADLGARVIKVERPDGGDFARHFDTACGSTSSYFAWTNVGKESIALDLKRPAGREVPARLVERADVVLCNLSPGAARRLGVDAETLRAARPDLVVGELSGYGEGGPYSTRKAYDALVQSETGLVALTGQGPVTARAGISVADISAGVQLHAAVLAALLHRQRTGEGCVLRLTLFEALAEWMHQPALYAQGTGTAPPRTGAHHPTIAPYGPYECGDGPVHLAVQNDGQWRRLCEVAGRPALADDPRFATIGLRVEHRAALDAELDFSAWRSSDLLDALDTADVPAALTRDVGRLTEHPQLTARDRVTSVSVPDGSVTLLRPPVDSTAWDWSPAPVPDLGEHTDRVLEWLGYDHARRRALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K0</accession>
    <name>A0A7W7T7K0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="772" mass="84330" checksum="3FA398E6B4347F36" modified="2021-06-02" version="1">MERFSPGQLLDPRHEVVPLRGRSAELAALRGWRDEHGGRRLMLLHGRAGVGKTRLVARLDDVTVLDDADLLPWHDLLARFTDGAVVLLARTAGWWWSAIRQRAEDLGFDTADLELTPCPREHEASYTDACLRFAHRFALPVPDAPTPAAETFHDLHLAALAAVHGRAETDRVELVRWLGSVDPMPPATRRQAEDALAVTLLDDRIAPERSPAALETLARAARRWPHVLRRAEELFTAEPALAATASSAALRVVADSPAPARAVARHVFDDPRFHRDPLPAMLTRTLLHEGARTAETPELAELYGMLSARAALASLKEEALEAATEEVALYRELAEADPAEHRGGLADALGDLGLRLVAVKATGRALATAEEAVEIYRDLTDGDPDYLPRLAAALEQVGVRYAATGRREDALHAVDEAAHLYEDLVDANGALFRIDFAKAAHHLAIRLFDLDRDRDATHAAHLAMVHWRSSAESDPRYEPEFARTLVAIAAALAEHGRPDDAIVVLEEASGVLRRLADANPRVFETELASALAAASVLLLRADRSDEARKAADEVVLLRRKLAAEDPAGRPALAAALVELVTVLTGPDRYLAAEDAVDLLRELDFPREALNADLADALRDQSVELVPVDPRRASELADLEVDVRRELDDGPAYAEAVLRTAMLRGATPEGLAAARMAVLLWHGMRTADELTTEPRYADALSCYARLCARHGGRLDGAMEVAHRAVMVLRAANASRDRFEDAVHAAETVIRAHPDQESARARMQALVVRDWPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7M2</accession>
    <name>A0A7W7T7M2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005427</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="40798" checksum="1DF4324EB5E62185" modified="2021-06-02" version="1">MLSMIDLFAGCGGMTSGFAKAGYTPVLAVEWNHHAAATYAANFGEDHIRHTDIATIRDKDIPQADVIVGGPPCQGFSNLGSRNIDDPRNSLWREYLRFVRRANPSVFVIENVDRFLTSSEFALLKDEIDGYHLSAGILHAADFGVPQRRRRAIVIGSRIGPIPLPTPTHDRWHPVRAVLDGLPERPATTALPATGTDFLGTRVPGVYKSADLHIGRNPTPLSLRRYRHIPPGGGRFDLPVELMPRCWREKKTGTTDVMGRLRWDQPSLTVRTEFYKPEKGRYLHPQWEPGEHGHRVDRPITHLEAARLQSFPDEFRWCGTKVEIARQIGNAVPPQLARSIAEHLRPYLTGGAPTVPTCPLCHTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Q1</accession>
    <name>A0A7W7T7Q1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Luciferase family oxidoreductase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="350" mass="37839" checksum="66643F9CEBDE7870" modified="2021-06-02" version="1">MTRLGEIPLSVLDLAPITAGTDARTALRNTRELAQHAEALGYTRFWLAEHHTMPGIASSSPAILIGHVADATEKIRVGSGGVMLPNHPPLVVAEQFGTLSALHPDRIDLGIGRAPGTDQRTAQALRRTSGPLSADDFPRQLQELRGYFAGTEQLDAVPAAGYGPPVWLLGSSTYSAQVAGLLGLPFAFAHHFSSEQTLPALTAYRERFQPSEVLERPYALVCAAVIAADTDEQALRIAQPSALAFLRLRSGRPGRLPTVEEAAEYPYTDLERLFVEDRLGSQIIGGPETVRAGVRELLDRTDADELMVTTMVPEQSDRLRSYELLAHMAGERSQLSTNGSSERVKSGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7S5</accession>
    <name>A0A7W7T7S5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="468" mass="52654" checksum="3212107608627468" modified="2021-06-02" version="1">MPGAFVNYRSGPHAEAVAAIAESLRRHFGADRVFVDHQMRKGSRYPDELRAALRDAEVVVAVVHQDWVARFGNEVDWVLWELREALDLGIPVVPVLLGDTPPPTSAELPAEIGEFAHRQASRLRAVSLTEDMASLLHELEKHITQPIAVRERPEPKRVAFWPRVLGWTVGTAAYPALIAVLLGAEAINFATAALSSTFILAVSLLAHVAQLLTVRQNTRLERRLGVLPVRAYVRKIWFYPLVAMVVLLAMMADNLPLTGVWWFAVVGLIALGLWFYGQRLFDARDEKEKEWPPTPSLEPYLYRRAAAHLHERLTTWPEWRWPRSRLHQGEAVAVYLDLTETKLALESRTRIRLGAWLRQERCGFSRAHLGWGAGIVAMYVVAALVLRPEQLVRDDGTLPTRAQLVVLTLFFGVAALVAAALTFVTLLVEVRIGRKSDRLLVAELEEWQSLLGPLVFVRPEDTRAFRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X0</accession>
    <name>A0A7W7T7X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="5974" checksum="6004757CB899D014" modified="2021-06-02" version="1">MTQARSGPVLVRPREGEPFVEVGAGSEVSTTTCRCYVDETVGPLARRPRSRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K2</accession>
    <name>A0A7W7T8K2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="8" type="ORF">F4559_005321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21871" checksum="3A6C85A2DE3F6FE4" modified="2021-06-02" version="1">MTQHFFPTPEMRSGSGMNLNDSVYERLLRERIIVLGSQVEEGIANQITAQLLLLAAEDPEKDITLYINSPGGSVTAGMAIFDTMQLIEPDVATYAMGLAASMGQFLLSAGTPGKRHALPHARILMHQPSAGVGGTAADIAIQADMLARTKQEMAELIAQHTGQPVERIVADSDRDRWFTAQEALEYGFVDKVVTRASQVSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T912</accession>
    <name>A0A7W7T912_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12855" checksum="C6C22EB67E9FCAAE" modified="2021-06-02" version="1">MKVEMVREANRVVVRTDDEAEVIEEVFEDTPLSFLREAVEAARAPERVPDDEDAAWWGGNYTQVTVRRADVFLENLYDFPEATLTHEEFIHLVTLYDQVKRTGEPGEWARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T992</accession>
    <name>A0A7W7T992_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="11" type="ORF">F4559_005696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="43242" checksum="C7C0264AC2423106" modified="2021-06-02" version="1">MTGQPNVLGIVLAGGEGKRLWPLTADRAKPAVPFAGNYRLVDFVLSNLVNAGFVKLCVLTQYKSHSLDRHISTTWRLSTVLGQYVTPVPAQQRLGPRWYHGSGDAIYQSLNLVNDERPDHVVVFGADHVYRMDPGQMVDQHVATGASVTVAGIRVPRVEAKAFGCIDSDADGRITRFLEKPAEPPHVPDDPEVSFASMGNYVFTTEALIDTLRADAADPDSAHDMGGDIIPALVDQGRAHVYDFSRNVVPGEAERHRGYWRDVGTIDAYYEAHMDLVSADPVFDIYNRSWPIRTATPPLPPAKFVAGGSAEDSMVGPGSIVSGTVHGSIVSSDVVIESGSVVQGSVLLPGVRIGRGAVVRRAILDKNVIVPDGALIGVDPATDRTRYTVSAGGVTVLGKGVTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A1</accession>
    <name>A0A7W7T9A1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase-3 subunit delta</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="40883" checksum="8AE053F3050AA8CA" modified="2021-06-02" version="1">MSGVWSGVVGQPEAVAVLGAAAEAAASIVAGGTPAPGAMTHAWLFTGPPGSGQAATARAFAAALQCVATDDRPGCGVCAGCHTTTAGTHADVRVVAPEGLSISVAEMRSLVQVSARRPTSGRWQVVIVAEADRLTEGAANALLKAVEEPPERTVFLLCAPSDHPEDVSVTIRSRCRIVPLGTPRAASIASALVTEGVAADLADWAASVCGGHVGRARRLATDDKARARREAVLRIPLALRRPVDIFTCADSLVRAAEEDAAGAHEGQDEAERTALETAMGAGGTGKGTAAATRGAKGALKDLEKRQKSRATRTQRDSLDQALVDLAAFYRDVLVSAAGVVLNHPDRAAESAAAAAEWSPESTLRRLEAVLACREALELNVKPRIAVEAMLTTLHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9E2</accession>
    <name>A0A7W7T9E2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MLTR_LBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MLTR_LBD" evidence="1">
        <location>
            <begin position="59"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="24146" checksum="174F9E81ABB61577" modified="2021-06-02" version="1">MSTVWYGKLERGEPGNYSADLLDRTAITLRLNEDERAMLHLCCTGREPAQQTRPAGALSAGLRAVIDRQTWPAYVSDCAWDILAWNAPAQEWFPWIVYEQNLMRWVFTYPEARHQLHRWDTDWAPLMIAQMQFAHARLPDNFRLAALIREILACSAEAREMWSATSAVAVHPDGDVRGLCLPDRDEVIRAEIVALSPLRSSDCRLVMLVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K8</accession>
    <name>A0A7W7T9K8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">F4559_006325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4968966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="11325" checksum="4842602C5173ADA3" modified="2021-06-02" version="1">MQQQGDWRIKAACRDEEPDQLFVRGAEQRKAKVVCLGCPVRTECLAEALDNRIEFGVWGGMTERERRALLRRRPDVTSWHELLDTARQEHFEESRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N9</accession>
    <name>A0A7W7T9N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="42137" checksum="04926CB77A71E0C6" modified="2021-06-02" version="1">MRLIRLGGEPSKVGADVRAALSTWGVGDAVLGGVALLGVRPPDCPRELDAVLVLPRGVLVVVGVDLPDPAKRLEAPLGGTWTIDGWPLSRGDGATSPAAEALEASSAVARRIQDMRGEPLPVTTVVAVGPYVGHVVQPTVDLNRGVRVLHPKPTTLLAAARELATGDRPCPVDQAARLIAVLAPTGTPPDPSALRAEGFPDAAVERTVLLPRAVPAKPPAPRWFTYVAVAVAAAVVLAVVVSLVSGGGPETTPQASASAQPTTVVVDGQDFVSRGTDRTEDCESHAFGDVRAWLGEHLCLRLDRAQFETKVDGRVVGVAVAELSLPDPQRAGQFGAVAAAAGSGGVTPLVKEGKGWPGGPASFDRSAIRTTVTGARVRIAQVVWADGESAADDPKLVAVAERASKLPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA47</accession>
    <name>A0A7W7TA47_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="43879" checksum="E9CCA0506A3649C3" modified="2021-06-02" version="1">MSSILEKRCRCTGETPNMVRRQRGSGGIADVGPLVPAAAAAGQDRLEAALLLAVNRAMAGLRRRGHPLRPTALVHRVQPDPRATGLHVHDAGLDGLLAEALPTIVGGRVRGVAGLRAFPGRDHLDLRSAHGQVRLLGVTRERWRQAVAAGVRVDLALSEDLDEREVTTAPGGPVALMSGVLRRLPLWRGALWLHCVPAGNALELYWRGGPPGESIAAILTGSVCAIPGATAVAHGYRETVRAMALSTDGTPCHGEPEWAWTQWVASTAPGPAVPERAVRPESEVDLPDVWEHDDMRDALASRDIGTVYRLLRHHGVPVTRIAALTGQTGGEVEQVLDGRRVDAYDTLAHIAKGLGIPPGYMGMAYDEPPSAAVACRCGVVDERRKREAFLTHAALVTIGRSGVSEPWSCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA49</accession>
    <name>A0A7W7TA49_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Deoxyribonuclease-4</fullName>
            <ecNumber evidence="9">3.1.21.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="13"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27155" checksum="6BCE3B3BFB8B6018" modified="2021-06-02" version="1">MRIGAHVRDDDPLAAAAERGAEVVQFFLTDPQGWKAPKAHPQADAILAGDVDVFVHAPYLVNVASLNNKIRIPSRKMVVQHADGAAKLGAKGLIVHGGHVTKGEDPADGIANWRKLFERQDGGFAVPILIENTAGGENAMARTFDMLGRLWDAVGEFDAGFCLDTCHAFASGEDLVGIVDRVKAITGRIDLVHLNSSRDEFGSARDRHANIASGTIEPQQLVDVVSAAGCPVVVETPDEGQAEDIAFLREHLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF7</accession>
    <name>A0A7W7TAF7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (Sigma-E family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006875</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19690" checksum="EA48AE8FDC652CE7" modified="2021-06-02" version="1">MREADESAFREFAVSNAAALRRTAFLFCGDWHTAEDLMQATLLKLYQAWRRVHLDTPAAYARKILLRTWLDERRRPWRRVEIGDGDVPEVADSSADPDLSDHRLWARDLVRTALLEVPERQRAVLVLRYFEDLPVSEVAVVMGCAEGTIKSQTSRGLVALRAAVEALGQGSVIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF8</accession>
    <name>A0A7W7TAF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24517" checksum="4FBEC3E6623C512A" modified="2021-06-02" version="1">MRDVDLRTALHAAFDDEPPLDFDPDVLMDRAKRGRTRRMALFAVVVLTLMACGSYLALPRLLANDRSGDVRVLGSGNLVPIPLIEEHVSARIAMAIPGARDVTVSISGTGLGPEDQLDLAIRFTDDLGVASAAMHIAGLDRGFSRGSFCAKYGCVRTLDQPDGSVVELAEKRDATVRRSAAHFRKSGIIVLAVAYAYDVTDGSDHRPSEPSLSFDVLVALATDPDLAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH8</accession>
    <name>A0A7W7TAH8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysozyme</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031083204" description="Lysozyme" evidence="6">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28746" checksum="9675CD512513233F" modified="2021-06-02" version="1">MSTRTWTALVAALSLTAPLAPAASALPAGSADHYAGSQIRKHEGTSARADGPPAYTPGSVPGMDVSSHQGDVDWQRPWDDGARFAYVKATEGTTYKNPNFHQQYDGAHAVGMIRGAYHFALPDRSGGAEQADFFVDNGGWWNADGRTLPGAADLEYNPYGDTCYGLDQNAMGAWVKAFSDRVAERTSRFPTIYTSTSWWDRCVGTSVSFGATNPLWVAHYTDVLGDLPNGWDYETIWQWQAAGLFPGDQNLFNGTHDQLTRIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAX0</accession>
    <name>A0A7W7TAX0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="28726" checksum="29071470BD8F1747" modified="2021-06-02" version="1">MSTAVATRAPLGRQLRSELRWILRRPRTVIGLASLCLVPILAGVGLWFSVTDGSPPEGPGISAIIGGNGLALPVFTLFLALPMLLPLVAAIWSADGIAGEAQHGTLRGLMISPVGKVRLLAIKSFGIATMSVLAVALITVVGVVVGVLLFGGDGLLTLSGSTLPFGAGLGRVGLTAVLVVVQMWGVAAIALAISTCTEHPLVVMASTLAGTIVFTVLGLFDSLSWLRPYLITSTWEGLADVMRDPLPTGQLWNATAVAGCYILVGLSLAVIRLSTKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTG9</accession>
    <name>A0A7W7WTG9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030725008" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13012" checksum="86F7A0AB0DC6CE05" modified="2021-06-02" version="1">MRSVRRCSRTGCANPAVATLTYAYADSTAVVGPLATYSEPHSYDLCEQHALRLTAPKGWEVVRHQGQFVAPEPTVDDLTALAEAVREAGRADRPVEAHDLPTGTIRRGHLRVLPDPHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT8</accession>
    <name>A0A7W7WTT8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04793">
        <property type="entry name" value="LanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033889">
        <property type="entry name" value="LanC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="379" mass="41166" checksum="41101B2B3A0BA3DF" modified="2021-06-02" version="1">MSDPHASVGTRDTRWAQSLADGAAGTALLHLEQGEEPRALLQSMVADPVRAHPDQATLFDGAPAVAFTLAATRHHGPLAVLDRHVDAITRSRLDAAHHRIDSGRLPHKREFDLVAGLTGLGAYLLRRHTPDRRDTPLADVLAYLVRLTEPRTDGLPGWWAADGPTGPGPDWSGGHGNLGIAHGIAGPLALLALAMRRSVTVPGQAEAVDRICRWLDLWRCGTGDRAWWPGTVTRAEHTAGTARNHGPHRPSWCYGTPGLARAQQLAGLALDDTARWRFAGRVLAECLSDQTQTTRLGDVSLCHGWAGVLHTAWRAGEHDERVRDHLPRLRDTLADRLRHDRHPPHGLLVGEPGARLALRAATTDTPPGTRWDACLLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU04</accession>
    <name>A0A7W7WU04_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036170">
        <property type="entry name" value="Prob_YezG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160424">
        <property type="entry name" value="SSF160424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15247" checksum="7B5026A332792A54" modified="2021-06-02" version="1">MQRIGNLLLDVAPPDFRRVDLLVRLTVGVQDAELTVYRQDGTSLAADLPDGLLAAFTEMRQVLYRPGRGAWFSARCVVNAPARIDITYNVDHDPKFVPEIPAEHFARDLEVFPRDEAFTPDWLRRKLAGAEEQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC1</accession>
    <name>A0A7W7WUC1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="22031" checksum="2DFC4794B854A06A" modified="2021-06-02" version="1">MEDHTEPSLGVDRGLDDRVRAAVGGDRYAIDRLLECIRPLVVRYCRARVGRQEKSYASADDVAQEVCLAVLTALPSYRDTGRPFLAFVYGIAAHKVADAHRASLRNRAEPVPDVPDAPADAVGPEQHALRTELSSQMGRMLRTLPDKQQEILLLRVVVGLSAEETAAVVGYSAGAVRVAQHRALSRLRRTIEEKRKVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV1</accession>
    <name>A0A7W7WUV1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8070" checksum="0B104A7A6A1C7E9C" modified="2021-06-02" version="1">MGTFTVPCPDCGHSFPMTTTTTRRGVDTDGHPVVNLTLDLTDAKTRFAAHVLLNPDQHPTFTIDTQPDSRETAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB7</accession>
    <name>A0A7W7WVB7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ORF">F4559_002494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09719">
        <property type="entry name" value="Cas1_I-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033641">
        <property type="entry name" value="Cas1_I-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019851">
        <property type="entry name" value="CRISPR-assoc_Cas1_ECOLI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03638">
        <property type="entry name" value="cas1_ECOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="35671" checksum="17D3AD0E04330F48" modified="2021-06-02" version="1">MPDVPGLPPVPISHLVRAQDRVSFLYLEHSVVHRDDNAITATDKRGTVHIPAATLGALLLGPGTTVSQQAMVLLAESGSTAVWVGEYGVRYYAHGRGLSRSSRLLEAQAALVSNKRTRLRVARQMYALRFPDEDTTDLTMQQLRGKEGARVRKLYRLHAQRTGVEWQRRDYDPSDFDSGTPVNKALSAANTSLYGVVHAVIVALGCAPGLGFVHTGHDKSFVYDIADLYKADITIPVAFDIAARDVADIGTETRRAVRDRMKDGTFLDTCVRDIKTLLAEEDVTTIYGPDAFDTYDETASNVVLLWDDSGRAVAGGTNYDDEDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC3</accession>
    <name>A0A7W7WVC3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="317"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="549" mass="55909" checksum="D6B35A1F491B7B66" modified="2021-06-02" version="1">MNTVLRDAVSGQWRTVSAASVLGAAHQAGEAAVPLLIGVVIDEAVRTGATGRLAWWIGVLALVFVVLSLSFRFSLRCGEAASHRAAHAVRTRLACRVLSGVRGRLSGELAGIATGDAQRVGAVNLALPTAFAAVVGLLVGAVALLRVSAVLGLLILVAAPLLLTAAHFLGKPLERRSDAEQDRAAMASGVAADLVAGLRALKGIGAEDTAAARYRETSRSSMAAAVRAARARAWLDGSMLTLTGIFLAIVALVGGQLAIAGDITVGQLVAAVGLAQFLLWPLTVFSWVNGMFAQGRASAARIAEVLAAPPAVPPGTAHLPAIAGHVELRGVTSGTLRDVTVVARPGELIGVVARDPADALSLLAVLSRDVDPTAGTVTLDGILLSTVDAAELRAALLVAAHDAELFEGSVLANVRDGGSRVAEALAAARVDDVARALPDGLDTTITARGRSLSGGQRQRVALARALAADPPVLVVHDPTTAVDAVTEVALAEGIRRLRAGATTIVVATGPALLAAADRVIFLDTGRVAASGTHADLVTSDDDYRAVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM0</accession>
    <name>A0A7W7WVM0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32345" checksum="290247AF7528CAB4" modified="2021-06-02" version="1">MGATFTAPASGAPWPDGRDPRATGSYVLAAATIPSQWHDLTGDGRSDLVAREASSGTIYVYPHSGSYNGTSTFGGRHAVLFGTEALNWIAVNEVTGDFAADLVGRRADGTLVVYPGSGRLQGGLTFGEAVEVGTGWNVITALAVADVTDDGEQDLVARWPDGTLSVYPHTGIFDGTNTWSPPETIGTGWNIMDWIGIAELTSDDSRADIVARRHDDGTLQLYPHNLWYDGTSTFVGPVRVGLGWHSVQIMTLVTVTIDDFTDVVTRNGNGELVVYRNAGGYNGDSTFHSPTVVGYGWNAMDLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVZ1</accession>
    <name>A0A7W7WVZ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="515" mass="55567" checksum="D5A6C37ECC266A83" modified="2021-06-02" version="1">MDRVVGALPGSHHVIASLEGEVRAQGTISNTRRMFVGGDVAANRADLVAELVDAGVDEEAVALRLLFPSVPHPLTSSTMWREVAAVPPGHYAAPGSTPDVVRWWTPPTPHLALAEGAERLRDALTSAVADNARSRPSISCDLSGGMDSTPVGYLAWQHNPDLLAVTMTELTSDDDDTGIAVDAAARMPGVEHLLMPASGLPLPFEGLFDPDQPHDEPFLGLQGARFREVARRVRAHGSTLHFTGHGGDEVLSAPPNYLHGLARRDPWLALDHVRGHRGLKRWTVSQTWHALRDNQSYRDWLERSAREITSPLPGGRLPPASWNHPLRLSPWLTQDGVHLVSEALGTAAVGAEPLAEDRSGHLALEQIRASGRVARLIGQLTATQGVRTVTPFLDDRVVEACLSVLPHERSTPWAFKPLLTAALRDVVPADIVRRSTKNDMSEDVHAGLRAQRSRIAALCDDLLLARLGLVDAEALRLAVLGPPPPGPALPIMVMTFNCEMWLRGATSLSTRSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWD8</accession>
    <name>A0A7W7WWD8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031385345" evidence="2">
        <location>
            <begin position="33"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="430" mass="47265" checksum="741EBF2CA09C94BE" modified="2021-06-02" version="1">MRRHVRKVWSVLAGGTLLVTLIPAATAEPSSAPPTGGTAETVVSRAFETTPDGKPLVPTGGRFYEAKATDFGVAQPGQVGATKAALPLPDVPSGWDVGHENECRSPANAGNVYSLEGWTQNHYRWCRGATVHWQRLKCGTSGCRLTDEILIEVMWLGYADARNRKFHIWGKTFDTVETIGEFEDDALVAAWADCAGEPGKSACSKRYQPDRRSTLEDIKEERNNVFESVLTDTSIADIGLTGDAIAPLQIYSWFTGRGGAGHAASILDSVGNRVASRCDSAQLRSKKACIFNNVRPFLTYDKNDTAYPVASLIDHIRYAQDQLRAPGRWRNAGPDGPPLTRTRNSDLQDENRKQPKAQCRTARPGGWNWRVEQCDEYPFASVKEGGASGGPVSGRLIPAAQNREGGIQLNNWYEWDRIIQEDTFWVNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG0</accession>
    <name>A0A7W7WWG0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="253"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="515" mass="53804" checksum="72B207166A306FAC" modified="2021-06-02" version="1">MLIAVVTVAVGIGVLGITQMSKLDARLRTVATMNAPALSDLGDIRGAQGMINHWAVMWYVDPTPEGHQRTRDGQHAADAAIDTAITSYLSHTTEPSGRQLASQLMADHRKFRVERDISYGDTPPAGYVPISDMTEFTNLIQRIDSSILELAKIEKASAENAAAEGAEAYSTARTILLLAMFGGLAAAVALAMLVASRIVRPLREVTAVTKRMADGDLTKAAVVKSTDEVGTLAVAINQARENFATAVSALATTAETLQSDSTRLVEVNDRLLTGTVGANDQAVTVATAADKVSLNLQTVAAGAEELGSSIREIAHSANEGATVASHAVQVAESTTDVVAKLGDSSAQIGNVVKVITSIAEQTNLLALNATIEAARAGEAGRGFAVVANEVKELAQATARATEDIGTKVEAIQSDTAQAIGTIGEISSIIAKINDYQLVIASAVEEQTATTNEMGRNIAHAASGSSEIANSISQVADTTKTSTQEIDQSRQAAVDLEQLSAHLRELVANFKYTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY5</accession>
    <name>A0A7W7WWY5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13297" checksum="F9FBCE366498341F" modified="2021-06-02" version="1">MIAFRFEMRGRARGWDSGMVATGSNEKSLENELPNLLHDARRRVIIELSPGEPETTPNTTPGASHVENGEPIMCYADTLTNDDGTATAFCYCGWSADHATPEAADTDAERHQTAADAAESALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX56</accession>
    <name>A0A7W7WX56_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="51"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="731" mass="76040" checksum="3B8A5577845A6A40" modified="2021-06-02" version="1">MRCSEISGIRPGGKTALLLAVVVVLWTWLVVPSVGASARILEPEPAVGSADIVLLVDESSSLSTDDVRREREAAAVIALGEFAPASRVAVVGFGSDNGASGQSAVDVVCPPTIVATAQERQVLSDCIGRLRGRTAAEGDGTDHYAALSQAMSYLSGSAADQKMIFLLTDGRLDVGDSEAYGSTSSAEERNKVALEKVDETLAAARAKGVTVWPLGFGTVDRAQLDRFAAGGHQGSCGRGVAKPTATVIEGSGDVVWALLQAYRLGRCAGGGEPREVTLDPGATAETTVDIPLIATDGSIVVVKQDPRLAVEYVDPDGRAVPKNGTVDDSTFQVSGENGAVEALRVVNPKPGPWTVRLKSFPNLPRTTATAVVTWQGAVRAVLTVDPPSPTAGQEVAIALALRTRTRPITDPAALSGLDFAVDSGFAGPVTLTDDGRAPDTAAGDGIHTGRATVPADAKGDFEVTGTVSGVGIASDTRSVRVPIATGPPELSATTSLDDTEAAPGAAIDGVVEVANTSGRARRVRLQLADIAPGTLVSVPGDATTFDVPPAGRESRPFRLDFADATPLGVNSFTLVLVDDEVPEVVIHRRQFTVDVVRPTPYARIGVVGGGVLVAVAALVAFVVWRRRRDVRGLVLHLTDRGRPRGDLAAPEMPARRFRFAVEDHPGGPARLEHTDAADAYSLTRVGGALRLHHPTGEVRDFLLGDRVALAGELSLAVVDERAAVVDDVPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX98</accession>
    <name>A0A7W7WX98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Multiple sugar transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="43055" checksum="07FEF78905A9EA3B" modified="2021-06-02" version="1">MGTGVNRRSFLAVAGLLGLAACGTNTGRGGSADGTLRHWYHAYGEDGVQDAVRRYAAAYPDAKVEVQWNPGDYDSKLLTALQNGAVPDVFEAQVKVDWVRQKQVVELDDLLGDTRDDFVRTLLEAQTVDGRLYGIPQAIDTQVLYYRPSLLAKAGVAPPRSLDELVDAAARLNTGGVRGLFAGNDGGVAVLTGPLLWSAGLDFLSADGNGPGFDDPRAATAFGKLRALHEGGGLLLGAPTDWADPGAFVDGLVAMQWTGLWNLPKITAAHGSDVGVLPFPRLDAAGAESVPVGAFSAMVNSRSADVEAAKAYVKWLWVEKTEYQTEFATAFGAHLPARASLASKSLDSGPGKDIVGFVTSGGRIASPPRWPAAANTALSDAVSRIARSGADASGELRAAVETARREIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG9</accession>
    <name>A0A7W7WXG9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="29201" checksum="1E83CE022DCCEE0F" modified="2021-06-02" version="1">MTAVDALEPVEVAIARPNAFRRGKGLVGLVLVGLVIAAGLLGPLLVSWDPYEQIPDANLLGPSGTHLLGTDDLNRDVLARLLTGIRVDLLISFTAVPIGALIGCAIGALATFSATLDVAVQRLFDVLLAFPQLILAIGLAAVIGPGTTSVMIVVVAVEIPVFGRLLRAAVLKVREAQFVTAAEVVGASRWHVLRTHVLPNSLEPVLVQLALSMSVAVFIEGAMSVLGIGVTPPDPSLGAVLNTALRYLDLNPMFAVGPLVVTAVLVLGFQLVAQAANAARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM3</accession>
    <name>A0A7W7WXM3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040496">
        <property type="entry name" value="MID_pPIWI_RE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025085">
        <property type="entry name" value="pPIWI_RE_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024996">
        <property type="entry name" value="RNaseH_pPIWI_RE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18157">
        <property type="entry name" value="MID_pPIWI_RE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13111">
        <property type="entry name" value="pPIWI_RE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13032">
        <property type="entry name" value="RNaseH_pPIWI_RE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="pPIWI_RE_X" evidence="3">
        <location>
            <begin position="13"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="MID_pPIWI_RE" evidence="4">
        <location>
            <begin position="525"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="RNaseH_pPIWI_RE" evidence="2">
        <location>
            <begin position="607"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="931" mass="104008" checksum="B692553FB3597DB9" modified="2021-06-02" version="1">MALNTRSRLDVLAYRGTPDLLGDAAVHIREFDNGVTSLWRLFDRDYRDYVKADEAQAPHSVVVNALRCLTGGYAAFDPDEGFLVTREEIDDDTLLAAFTLMHGRVLGTPIDDIDLKEPPRLAERIAETKQERRLLADYLRTTETGQPDAPTWVYKTVAWDLSRRIAEQPWRVDGQEIALRVDSRGGLVAWQDPWTNRSGTAEALSRASIDMKTLPNIADPILLVSPTVTRIQSRMAWARTVLVEQDDPARPIVEVAMAGRSSVRRVSAMALDVLAKLGVEQSILRHVQNRVVLENRIQNEQDEAPEQEDIWAPDSTPAPVIRPVQSKNFRFPIGRGVGMHHHRELRRHIDEVLGDALVKTTRLPVYFEGRNFKQVDTDRLLPTPEDVVRSLTTMGYRHLRIVCLWNTDEVRHRMLDGLRHAYSANGRPADDQVPGGQPLDPVDGVPVALNGEAISAVFHRVPGFLEHGPDAGSAEAIAHVQLDCGPDTLVGVWAETEFTRRGDDEDEGYEEDDEDGIEDAAAEQTAGVKEDEDAKFRARRTLALKGVNSQFIVHRKPRKPRKGKKVRDYPVIHSLLDLHRSLGIIDQRITDVMVDRLGTHAPTGVAHCAVHIRRQSRRGKDRTAKICITATVLKPPAHDGQAWTLHGWSYTDPTWRPYNQAQAAFHAKDYPTGKMTELQDDNAGYKKVATRVDDALAELVRYLGGMPYTITVDAFGSRRLWSGLNNNKQGESERPGTWLPGSTIHPSDRPRAIVRVNKNADEMFRALGITLLDENGEKISDGDRTTNSLFRVKSDFGADSFALITVPHQYDGQGAGRLGSDKTRWSADHGSDVEGELRRNEMKDNWYSMTTLGIFPVAVKDEIKPDKLALMTARLCHQALAWAERTTYPAHLHAASKMDLDHPQYRRTALPTDSTDTGTPDDLSTGSGELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP9</accession>
    <name>A0A7W7WXP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arc/MetJ-type ribon-helix-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14122" checksum="4101B741BFC492C9" modified="2021-06-02" version="1">MTARDPADESARPHPGRADSVARLARQLGFLHDEGKAPEAFASTARTEHGHDERPLGRARKVSVSMPEELTVAVQRRVGRGEFSQYVTEAVTRQLELDLLGDLAALLAEEHGAVPEEFLAEAGAAWPDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXT2</accession>
    <name>A0A7W7WXT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030644451" evidence="1">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="25928" checksum="A08DAA3717705D5C" modified="2021-06-02" version="1">MDLGIKGRVALVAASSSGLGLAVAKAFAAEGAHVSICGRDPARLAKAHAEVNAAGPGDVLSVPVDIRDEHAAAAWVRHTADVFGGLDIVVTNTGGVPFGPVDSFEPADYREAVDGNLLPHVSITLAALPILKAAGWGRIVMIASEAVKQPSPASGLSSVARLGLLGHMKGLVHALGANGVTVNVIAPGYHRTPILDEQFGDHVEDELARVARGIPLGRIGDAGHFGALVAMLSGDQASYVTGTVLVADGGNTRGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY06</accession>
    <name>A0A7W7WY06_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase (ATP)</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07905">
        <property type="entry name" value="Adenylation_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07970">
        <property type="entry name" value="OBF_DNA_ligase_LigC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044119">
        <property type="entry name" value="Adenylation_LigC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044117">
        <property type="entry name" value="OBF_LigC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="4">
        <location>
            <begin position="111"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="44251" checksum="F22814C087A4E485" modified="2021-06-02" version="1">MNLPVRPPVRPMLARAVREVPRGAGLVYEPKWDGFRCVVFRDGAGIELGSRNDRPLTRYFPEVVELLAAGLPDRCVVDGEIVVVTPDGLDFGLLQLRLHPAASRVRRLAAETPASFVAFDLLALADRSLLDVPFGRRRELLVEAVTELPGLYVTPCTDDPDVAQDWFTRFEGAGFDGVVAKDVDLPYQQDKRVMWKVKHERTAECVVAGFRWHKDGEGVGSLMLGLFDDVGLRSVGVASSFSAARRVELLAELAPLRENALDGHPWADWVGDPTGAPSRWNPDKTLTWEPVRTELVAEVRYEHVHDHRFRHTARLVRFRPDRDPASCTFAQLEEVAPAELAAIFAVPVPSAPNPSGEHDDRRVEHRGEPDPQQVGHEQQPGDEVPADEQGEQQRDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY14</accession>
    <name>A0A7W7WY14_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33238" checksum="0EA2F4BBC0ADDF1A" modified="2021-06-02" version="1">MFRDLRACLALMFLAPLVGEFLLGNVPIVALPALVFLVPMYGGAALLCRELARRTGRGLPTMLLLGAAFGVLLAGVIDQSMFNPDFEGHDFQATTPIPALGISALKALSFPVGHAVWSIGTPIVLVESSAWSRRTTPWLGVRGLIAVGVVFVAGSAAVFRFMYRKEGFLASPAQLGSAILVAALLTTIAFRLPRTGSRRDRWVPHPVLLGIGSFVATSVFSGMEDSWTAFAVDVVMIVVIASALVWFANSTRWRAGHRFGTAAGALLTYAWLGWFLVVPAPPFLLAHGVLVVLFLVLLVVCGRKVRLTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY25</accession>
    <name>A0A7W7WY25_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (DUF2252 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018721">
        <property type="entry name" value="DUF2252"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39441">
        <property type="entry name" value="PTHR39441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10009">
        <property type="entry name" value="DUF2252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="438" mass="49219" checksum="A96B9902E57BC60C" modified="2021-06-02" version="1">MDARGDRIVEVLRDAFADLMSADPGAFRHKFRKMAADPFAFYRGSACLFYADMADEPDDWTDERTSRIWVQGDLHAQNFGTYMDSEGTLVFDVNDFDEAYLGSYTWDLRRFVASLALLGWHKAFPDDTIAHLVRTYVKAYVAQVRKFAEHPGDELFSLRLDNTTGLLHRVLCRARLARRVDLLAEKTTIVDHDRRFRLDRSGTHELDAATRDRVRDAFDRYLDTIPSGKRSTRSLSYAVKDMVGRSGFGIGSAGLHAYNVLVEGRTQALENDVVLSMKQANVAAPSRIVHDDRIRSYFTDHGHRTAVSQRALQAHSDPWLGHTSIDGVGYVVAELSPYEADLDWSDLTEPADMLPVLEHLGHATAKMHCVSDEDSDQTLVDFQCEEAIAAVVGGRDEEFTEDLVAFAHRYAARTRTDHSLFVDAFRSGHINGLSATAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY33</accession>
    <name>A0A7W7WY33_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22150" checksum="5B9F00AA893B08E7" modified="2021-06-02" version="1">MPEETVKRRRAPAMSTEDRRQAIIDATVPLLFEHGAKVTTSQIARASGIAEGTVFRAFKDKQELIKACVRAALGVEDELGRLRQARLVPTLHARLALGIAAVADYLDRMWRLMGALGESGYDAGADRRHDDGPPKEMLRISAHLAALFEPDADALRVDPELAARLLLGLVFTNRMRGAGFGDTAADGDGLVDVFLHGVLRGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK2</accession>
    <name>A0A7W7WYK2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38819" checksum="B22514F2D9305E03" modified="2021-06-02" version="1">MRAAVVGGGLGGVAAAVALRRIGWDVVVLERAAEFGEVGAGIGVMPNALRALDLLDLSSEVRSVGTPRVAGAVLDPRGRRLTHVDAVHQDQVVAVHRADLHRVLRSALPAECLVTSTEVTSTADLDADLVVAADGIHSRIRAELFPTFPRPVYSGATAWRSVTSAVFPADLMISQTLGSGTEFGVLPLGDGRVCWYAATVAAAGHAVEDDLAEVKRLVGAWHDPIPAVLDATPPGTILRHDVHELKAELPTFVRGNVALLGDAAHAMTPFLGQGACMAIEDAVVLAASLREHDLPTGLAAYDKARRTRTRRIANASRAAGRFGMFVRTPIATTIRDTVMRAIPSRLAIRGMTRFTSWNPPVDSLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM7</accession>
    <name>A0A7W7WYM7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein CpaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030858997" evidence="1">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="17012" checksum="6F58F3B89BD7EA37" modified="2021-06-02" version="1">MHNLRKVLAVLSALTGLFLLLRPAPPTTTVLLTTRDLPPGVPLAKEDVRTTEIPATLAPPGAATPTSAEGRTLGSPAGAGEILTDARLTTADPDTATVAVKPTDPAVLTLLKPGGRVDVVTETGVLAENATVIAVHDNTVVVLSTDATTAARVATESLTHPLAVTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU3</accession>
    <name>A0A7W7WYU3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18187" checksum="7C333DA770CAFD92" modified="2021-06-02" version="1">MTAQPGATAPPPRHSTDPGTSEQRRPIGSYERYSEAERAVDYLSDNGFPVERVAIIGSDVKLVEQVVGRLNLGGAALRGAGSGALTGLLIGWLFGVFNWFTPLLAAFTLAIYGLVFGAVIGAVFGLVVHALQGGRRDFASVRAMTPTRYEVVADEAVADEAKNLLAKLKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV6</accession>
    <name>A0A7W7WYV6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-dependent DNA helicase DinG</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="36"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="674" mass="71743" checksum="D30D79DF0399C3B3" modified="2021-06-02" version="1">MPAITLPDTATLLAVAVEAVGGAERTGQVEMARAVERAIHTGEHLAVQAGTGTGKSLAYLVPALRHAIAEESTVVISTATIALQRQLVDRDLPRLAKALKQVLGREPRFAILKGRRNYLCMHRLHSGAPEEPEEAGLFDPFAVSRMGREVKRLHEWSSDTETGDRDELVPGVTEQAWKQVSVTARECLGVAKCPIGVDCFAERARAEAGRADVVVTNHAMLAVDALEGYQVLPDHDVVVIDEAHDLVDRITSVATEELSGTLVSTAARRCGRLIDQDVADRLAEAGDGLAMLLEDMPAGRLDALPKALAGALAATRDAAHACISSLGPERKEDVDGATSRKLARSLLDDVHDCAVRMLEAFDEDHDVVWVSGDFADRGRAPSLRVAPLGVGGLLGERLFGKRTTILTSATLTLGGTFDTLARQWGLPATSTAVATQGMATAKEAPSDLTPVRWTGLDVGSPFEHGSSGILYVARHLPAPGRDGLPPAYLDELEGLVNAAGGRTLGLFSSMRAAKAAAEALRSRLEYPVLCQGDDSTGQLVKRFAEDTRTCLFGTLSLWQGVDVPGPALQLVVMDRIPFPRPDDPLASARQKAVESRGGNGFLTVAATHAALLLAQGAGRLLRSMSDKGVVAILDPRLATARYGGFLRASLPPFWTTYDPEIVRAALKRLDATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV9</accession>
    <name>A0A7W7WYV9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="42558" checksum="4342BAA83F760765" modified="2021-06-02" version="1">MTERIRAHDVDDRRHRALDDAFHLLSLPTVDPLAPARRLALIARLMARSGRRVGAAHHADLARRALPLGGGREAVRVTDVLHRVEDECVARVESGTPAGSNRPRRPRVTGLSAPTSYALGRAREALLWLDSTVETSRFTARWPRTVMIREARDSARLDGLPVALVELLHQALYRAHPTHVDSDLSPYLKGVEGPASPTSSPEPGMPTTLVLTHVRRLVNPQATAGARHAQRLGLVADAVHDGLLSRPVLPFTGWLADHAETFRHLTGTATTTAGTDGLVRFLAEGIVAACHHEMALINALPGLYDRLAGRLPHNPSRFQRSVLADLVAHPVTSGPDLVRRHNMTSRTAVNTIAAFRDAGILLPHGTTKYGRTVYCPAALELVHHHDTTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW7</accession>
    <name>A0A7W7WYW7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19374" checksum="DD0CFE054A5CAB00" modified="2021-06-02" version="1">MSRTVTVYCGSRTGVPRSYLDLATRVGAEIAARGWSLAWGGGRTSMMGCVAQAARDGGARTVGVIPRSLVDREWADREADDLLLVDTMRDRKALMEAHGDAFLALPGGIGTCEELFEIWTGRVLDMHDKPVVLLDVDGHYRGLLDWLDELRSRGFVSGYALDRLVVTDDVTTALDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX7</accession>
    <name>A0A7W7WYX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase-like metal-dependent hydrolase (Beta-lactamase superfamily II)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="32"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="30499" checksum="919F6C78B1154132" modified="2021-06-02" version="1">MKVHHLNCGTLRPVGGKLVDGRPGVFRTAELVCHVLLLEREDGLVLVDTGMGLEDVRTPSRTLARHWRLMSRPVLDERETALRQVEALGYRASDVRDIVLTHLDLDHGGGLRDFPEARVHVLAEELAVATRAGKTGNDRTRYPDAQWAHKPRWVTYEDSGESWFGFDGVREVLAGVLFVPLFGHTHGHSGVAVDTGSGWLLHAGDAYFHHRETGPDAYCPPALRFLQKRMEVLPELRLSNQDRLRALVGAHGAEVDVFNAHDLENFRRFRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY1</accession>
    <name>A0A7W7WYY1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="40973" checksum="E92EB4E15318A944" modified="2021-06-02" version="1">MTAAEQSTVDDLMTVRGLKVHFPIKRGVFLDRTVGYVYAVDGVDLSIRRGETYGLVGESGCGKSTLGRAILRLTEPTGGEVVFDGTDLSSLRGEPLRTMRRRLQMVFQDPMSSLDPRQSVESILVEGLRAHGLDKGRESTAKRLRELLAAVGLPTTSLRKYPHEFSGGQRQRIGIARALAVEPDLIIADEPVSALDVSVQAQVVNLLEDLQEQFGLTYLVIAHDLAVVRHISDRVGVMYLGGLVEEATSDGLYAEPLHPYTRALLSAIPVPDPEVEDRRERILLTGDLPSPANPPSGCRFHTRCPWRQATKCDTERPVLREVLPGHRVACHWAEGIRSGEIRPHEVEPVLVEEDGLSPDLPLVGPASVTEALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ15</accession>
    <name>A0A7W7WZ15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20043" checksum="90AC64DB8CA31E76" modified="2021-06-02" version="1">MATSDALAIVGAITGSVSLIWNVSSYLLAGGRASVEIGIGLYNGTDLFIMPTPKEGINVYDNPLSAPIDNVLVIQIFGKGRQGLTVDGVKLVDRSGISYLPTRFLRGGLPARMEVHASHTVVLPMNEVNVNVHHALRKTQMTELRLRAVVRFGNGKAVRSKPIRFYAGEDPYIRGPVASDERDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ65</accession>
    <name>A0A7W7WZ65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="45327" checksum="F71B14B7A7E0126E" modified="2021-06-02" version="1">MLTLNDRITDRVRRRDYHQWRDAVTAIGGCARPIHLTGTWQLTDRAGTVLAHRGGNVMVPCGNRRASVCPTCSDRYAADAFHLVRAGLSGGKGVPEAVIKNPRWFVTLTAPSFGPVHSVTRRCCRRRHRPDDPVIGTPLDPDRYDYVGAILWQAHAGKLWHRFTIALRRHLANAAGLRVRDFHARISYAKVAEYQRRGLVHFHAVIRLDGATAEFIDQAIHAAARAVRLRTRRPDGTPFALVWGTQLDVRPIGDTDVTLASYIAKYATKGTGARDTPDRPIRSQRDVDHLDVGDHHRRMIQTAWNLGALHRYMDLNLRKWAHMLGFRGHFLTKSKYYSTTFTRIRDDRRAYRLAEAVHSLGLEPDQVVVINHWTYTGSGHRNDAERELALAMARSRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ75</accession>
    <name>A0A7W7WZ75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="6032" checksum="0B98F45D3CA34ABC" modified="2021-06-02" version="1">MPWVQRHRRRLPGSWFRTTTVDAHHRRRAGHIPWLPILVVVAVILVLVALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB3</accession>
    <name>A0A7W7WZB3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase (GGDEF)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="353"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="492" mass="52445" checksum="3F69E20DEB1E91C5" modified="2021-06-02" version="1">MDRPEPPATAAPPDHEVRTLLNAGRLPEANRLFDRVVSTRPEAGDRWERSAVLIDRAKLAWRLGRIPLALELAAEGWSDLDSDAGDNPAAARAMHALAYLLEGIGNRRAAIDMLRLSVDVARRSGDREILGHCLQGLGGTLNFRAIAAPAEVAPAVFTEAAECLREGLELAEDRLMRLALMGAYSRSLAGMGESERAEEVATDTLAQARAAGDHWAMAVANWVLAGVARDRDDPATARTLASRAVASAEMINDTSLLLRFSLDLADLCARMNDSVGEAAALRRSVAAGRTVLETLQEGLGQALEQRRVAVAAQRLAVAAQEAATRDPLTGLANRLGLERAAPVLLESTAAKGRVPWLVLVDVDWFKGVNDDAGHAAGDAALREIATLLRRECRADDLVARWAGDEFVVLLGGDAPDTGPTVAERIRAAVDAHDWTLVLGSVRRPTVSIGVAAGPAKLDLLFGAADIALYRAKRQGRNRVEVEPSIDVASVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZF3</accession>
    <name>A0A7W7WZF3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="18998" checksum="0C553C948CC0050A" modified="2021-06-02" version="1">MGDFGPDGTQPPPPPALFPDPLAGLVTGEGFTSSGPRADRSGPAAVEPTGQPAPLPVVGRSVPAQAGPSRQPVRSPAGRPVPPRPGDRSVPKPSGGPVRATARRVPPPGVGARPAVVGQGVPPQVRLPAARSAPVVRPPAPARPTPPGTAPEQRKSRGWLGCLVLLGLIAAISPVLRAIIEAVVDLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZG7</accession>
    <name>A0A7W7WZG7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrmH family RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24434" checksum="AA7A0A834CA9B4E0" modified="2021-06-02" version="1">MKVLLEGFHAVKHALRFGAHVDPLLVLDLDATLDLARSHAPDLVDEFAARAEPATSAGFARVLGHARSHPTGVVGVADRPSAADPLVGRSTPVVLLDNPRNLGNFGAVIRVAAGLGAGGVVSTGEVDPWHPNVVRGSAGLHFAVPVGRVADVGLIRGEVVAFDAGGADLRDVRLPDDAVLAFGSERHGLSPAVRDRADRVVSLPMRERVSSYNLTTSVAMALYHWELFRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZL6</accession>
    <name>A0A7W7WZL6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030763098" description="LTD domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="814" mass="84455" checksum="4425A189A508D38E" modified="2021-06-02" version="1">MRTDPLRTGLVLTAAAAVTLALAAPASATPSPDALIAEVYGGGGNSGATLTQDFVELANRGTASVGLDGWSVQYLPASASAASQWQVTPLTGAIAPAGRYLVAQAKGTGGTVALPTPDATGSTALSATGGTVALVSGTTPLTCKTVADCGADTRIRDLVGYGTATVVRETTPTANTANATAAARPALVDTDDNSADFAIGVPTPTNSRGETPGGGEPEEPQPGDKRVHDIQGTTRISPLLGQKVAGVPGVVTAVRAVGDRGFWIQDTAADNDPRTSEGLFVYTAGTAPTVETGDAVLVSGTVAEYRPAGDTASNSNQTLTEITGATVSVVSRNNPVPAPVVLAVPDAYLPANGGASIESLPLDPARYGQDYFESLEGTLVQVNDARVVGPTNGYNETWITARPDQNPTVRGGSIYLGYDQPNSGRIKVKPGAATPAKSNVGDVWRGATVGTIEYTDFGGYTLATKSVGEYVSGGIQPEKTDAGRKSELSVATYNVENLAATNDQAKFDRLAGAVVTNLASPDVVVLEEIQDDNGTVDDGTVTANATLTRFTDAIAAAGGPRYQWRQIDPQNKTDGGAPGGNIRVAFLFDPARVQFVDRAGGDATTPVSVVKQYGRAALSVSPGRIDPANPAWESSRKPLAGEFKFRGRTVFVVANHFNSKGGDQAVHGRYQQPNRSSEVQRAKQATALRAFVDQVKAIDKGANVVLAGDINDYQFSPAVGTLTAGGAVVDLIATLPPAERYSYVFEGNSQTLDHILISSNITRYRYDVVHVNAEFADQASDHDPQVVKLRPSTGDPRVDRLLFALEDLAECLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZW4</accession>
    <name>A0A7W7WZW4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="105"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="33772" checksum="49A2CA31CA378657" modified="2021-06-02" version="1">MRTERGTTIRSRELGEELRLARKRIQLRAEKLSQSLGWSAGKISRLEHGSRGTSDFDLGALLGRLEADPTTRDRIRRLAEEPDIGYFLRTHDGRIADSLTCLTIHEQAASGIYKYEPMLISGLLQTERYARAVIDPDGKFDPEDRAMMVGARMNRQSILSSTTTTIFIHETALRTSIGGHEVMHDQLLRLVFMCGWNGLTIRVIPLAAPGELVAPGHPALRHGHTLLTFPRVLSPVAYTETDFATVFSEESNSIERYRLKHRTLDSLALSVEQSQAVIAYWANVYDRREEPQDERFDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY46</accession>
    <name>A0A7W7SY46_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="152"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="42963" checksum="AB239AE44A1467D7" modified="2021-06-02" version="1">MTTAPASRTGTRLGVLTRRAGDTGLLAALPAPIGALAWVRNGSGLVGWGEAARFEISGPDRFALADRWWAEFTASLDVVDEVGVPGSGPVAFVSLAFGDEDRSVLIVPEVIVGRRGNHSWVTTIGTDPELPVTAVRRPTGVRYLDGRLPVPAYREAVRTAVDRMRAGEAAKVVLAHDLLAVADEDIDQRHLLSVLARRYPDCWAYAVDGLIGATPELLLRRTGQVVDSRVLAGTTWPRDGLSDAELASALLTSEKDLDEHRYAVRSLADALRPYCSSLSVDGPAVLHLPNVSHLSSDVVGTLRDSPSLLGLGAAVHPTAAVGGTPRAAALAMIADLERMDRGRYAGPVGWIDGSGDGELGIALRCADVEGRTARLFAGCGLVASSDPDTEVREAHAKMRPLREALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ41</accession>
    <name>A0A7W7SZ41_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031468941" evidence="1">
        <location>
            <begin position="30"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13446" checksum="3E95129C74D1CE22" modified="2021-06-02" version="1">MRAGRPVATILLALGLAGAISGCEAVQQASDTANQVGNAADKVTLCVEALKLAGFTPDATDPQKAVEETQKKAEELNALAAKAGDTTLKDAITGVSTTMSQVTVQDLSPASIAEWSQKKLDQFNALSKACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ63</accession>
    <name>A0A7W7SZ63_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division septum initiation protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="445" mass="48662" checksum="7E5A9AACE1CBEBE0" modified="2021-06-02" version="1">MGLADDRDLVPLGTGFDIVKRGYDRAQVEEHLHGIDSDLRLLAADRDAAVSQTNDLARQLEAARSEIADLRGQVERLSLPPTTLEGLSERLQHMLRLAQEEANEIHARAEAEAGHVRARSEAEALTLRTRYEQLISDLDRRRADMEAEHRGVLETARAEADRIVGTSREEAARLDEESLQRRTTVEEDFEIAMAARRVESMRTLAETEASSKAEADRRVREATDEAARIRTQVAQEQAAANAEAQRLVREATEEANRRRHDSISEATARVQEAVDESNRRVREATEEANRRVTAASQKVDSLRNLRNRLSQQLHAARAALLEVTPLLDPLEEEKPRPVPATTIQPAAGTVVEPAAAQAVPAQGGPAKSGPNPESARNTTTQVAPVQNAPAQPTPGPSEPGPAPAADATKRTETKAKPADEAPTSKVDGPTRKIPRPNPRAHTGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ98</accession>
    <name>A0A7W7SZ98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose/arabinose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031464472" evidence="2">
        <location>
            <begin position="31"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="106"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="39589" checksum="5609C64DF509A37D" modified="2021-06-02" version="1">MSRLRTVLVASAVGLLAAGCASFPDQPAPAGWSAQVQLTPQAGPRPELPGELPSSPGQGQQPGQSAVPVPPPEGCKDFNPAVVATCLNTVTGVAMIDVDETTGSVTALATERGGRLLRVAKDVEPVVVATFEVDASGDGGLSGLALSPTYAEDQLVYVYVTTATDNRVLRLAPGDVPKPVLTGIPKGATGNRGALASDPSGALLVATGDAGNAASAADPASLAGKVLRIDASGQAAKGNPTEGSRVVTSGLHSPGGLCLATDGSKLWVTDSTPTSDLLFRVEPGKALTSAAWSWPDRPGIAGCASMTGLIWLATTKAPGTLSLHLNPDGSFSGKPERNLDDDKGFGRLGPMVALDDRTALVGTVNKVPGATPVSSDDRVVIIVRPDSAGGGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC6</accession>
    <name>A0A7W7SZC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="28819" checksum="63916F63CD6DA757" modified="2021-06-02" version="1">MLDRMREHDVVATDGTRIRAWDTGVGPDVLLCTGLGALPGAWPAAGARVRGWHYRGTFGSARPDDPDRIAVDDHVADAVAVLDDAGVGRCVVAGWAMGVTVAAALALRHPERVSGLLLVAGAPGDAFAGAFGVPGVPESVRRALGVLSVSALRLAAPVLDGVLHRVPLAGSLGAVLRHDWAWYFTLSLALGRTPRFDLRPLTCPTTVLAGRYDPLAAASDVVGAAGSLPQARVRVVPNTHLLPVENPGLVVAELDALVRRAAAVREALLLTPRSPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZI7</accession>
    <name>A0A7W7SZI7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TP901 family phage tail tape measure protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMin_Tail" evidence="1">
        <location>
            <begin position="87"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1256" mass="125972" checksum="3EAC928E5BB6B5BB" modified="2021-06-02" version="1">MAGGRIDIEVAPDLSRFPGDLSSGLKAQTGLASSLGRGLGLAVAAGATVAAVGLKKVIDLGVQYTANLNELQAVTSATGFEMARVGETAKALGADISLPGTSAADAAAAMKELAKGGLDVNEAMTAAKGTLQLAAAAQVEAAQAAEIQSDALNQFGLAADQAGHVADVLANTANAASGEITDVANALKYVGPVAKTVGVDIDNVATAIGVVATQGIRGEQAGTSLRGVLASLAAPSKPAAEGLKALGIEAFTAEGKFVGLRAITEQLAAAKGRLSEAEFTAAAATAFGNEGLTVASALASSGAAAFDSMAGAVTRAGGAADVAAAKTKGLGGAWEGFKSQAETFGIEIFEAIDGPLEQAVRAATDQLSKLGPAIADGIDTAVAVGELYGPRIAAAIEARADVVAQAGRDVLGPLVEGAIGPLNAAVNTALGLWGNFTGVLDNAVDAAAPAAQGLGAVAQAAADGDGPVSALASGLGLVGDAAQAASGLLVPIGEIVGVIAAGFAALPGPVQSAAVAMGLVAAFRGPLTNLGTTVRDRVTMPFQRLNETVRLQQALLTGSTQIATTQVGRLGLAFAALEARVPVIGRMADSYRTASTAAQGFVTQQSAVAQVAAGISGQYTGVANVIQRTEGALRATAGAAAGTAAALGTGLQSAATGLVGALGGPFGVAIAAASVGLSLIADRQAKAAQQAQQHASQVDSLTAALVESNGAITESVRAAQAKTLQGTKVADTDRNVADAAREAGISLSDLTDATLGNGTALDGLRHKLEEVVKAGTKYQDTATGWKSGQVETVKTMSDEARAAESLLGEINKLADVYGESKRKQEEFDRAVREGRASIVDATSSGRALAGAMTTLSDATASADDKARALKNALDALSGGQIDLEEATFQVEEVLDRLGETFNKNTDKSKGWGTELNNAGAALIKADGSINGATQNGRLLRDTLESLTEASASVAQSTYDMAIAQGDSVPTATAKATAAVKHSRDAFIALAEDMGLSATEAANLATKAGLIPENVAILVSTPGSDKTRQELIMVKGLADALPPDKPITVRSLSDEAKAKLIELGYTVVTTPNSVTITANSDKAQQQLNAWLSTPATKTVYVNYVLPGNAGSTERIGTPGTGGLAAGGIVAAAYASGGVHKLTPMRAGLARIVPPNTWRIVGDRVVDDEAYIPINSSVRSASLLAETASRMGYDLIRRFAVGGFARGGEGSGSAPVLPGVDGWRISGELRVNGLDGHIDGRIGTAMDRAGTALTRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL4</accession>
    <name>A0A7W7SZL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15301" checksum="482E0900B33CA216" modified="2021-06-02" version="1">MRIVSAMANGGAFAVNGEREAVVVVAPGAEYTPNAQWYLEIEGQAAEIRSKVTPGCLQADPRPDDPGQGGLVPGNRLIVGECSGEDDQLWRVAGAPKGRWTIGSLVDDTLVLSVGKPTHSADAEIWLGVRGISTASEWTIEPFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZR6</accession>
    <name>A0A7W7SZR6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="18775" checksum="0D40CCC7D5ED051B" modified="2021-06-02" version="1">MDRGEDLVRRLDDRWRGPLHGYVLRLVGGDHQKAEDVVQETLLRAWRHADELHPDQAGPWLYTVARNLVISGYRRRGAGEVPLGPDHLPPVADRVDQVLQNWQVAEALRALSDDHRAVVVELYYRRRTVAEAAAVLGVPSGTVKSRCFYALRALRDALEERGVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ4</accession>
    <name>A0A7W7SZZ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18382" checksum="12BD64C5A6FD82BE" modified="2021-06-02" version="1">MTAPPAAVAERLADDLHAISVHEAAHAVIGILLGLPVARVWLAWRKPWLSDWHVQGRSELSRRVDEHPDVAAVVAAVGPAAEIRCRVARGVRPSAARRQVHRARCNRGDFREVAAALRDRESELDAAGLDVEVEGLLDLNWDAVTAVAAALRDHGRLERRDLDRLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T002</accession>
    <name>A0A7W7T002_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein YeaQ/YmgE (Transglycosylase-associated protein family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="8991" checksum="3CF495849C2A1E83" modified="2021-06-02" version="1">MGILSWIILGLIAGAIAKAIMPGRDPGGIIITILLGIVGAVVGGFVGQALFGSDIGSFFDLSTWLLAILGSLIVLGIYRAVTGRRSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T052</accession>
    <name>A0A7W7T052_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
            <ecNumber evidence="1">4.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="25535" checksum="3FA13C5E0EB408A3" modified="2021-06-02" version="1">MGEVLIEHHGRVAVVTVHDPDRRNALTLDLSAGLAEAVHACEADTNVHAVVVTGTPPAFCAGADLTALGEAREEGLKRIYAGFLAVAACSLPTIAAVGGAAVGAGLNLALACDVRVVGPGARFDARFLQLGIHPGGGMTWMLQRLVGTQTATAMTLFGRILDADEAVARGLAYERADDPVAAAVALAASSAEASRDLVLAIKATMRKTAATADHATAVATELVPQAASIGTPEFQEKLARLKARITART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T073</accession>
    <name>A0A7W7T073_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="24637" checksum="3E90A2FF45035E71" modified="2021-06-02" version="1">MGLAGHEVLAAVLQVRAGSLQVMLWQRAREPHAHRWSLPGGALGDREDVEASIRRQLAEKVDVRQLSHVEQLAVFSAPSRVPGGTRVVATAFLGLVPSSIDPVVPGDTSWYPVSALPPSAFDHEAIVRRARHRLAAKLSYTNVGFALAPPEFTISALRALYSAALGYKVSATNLQRVLSRRGLLEATGATAPPGPSGGRPAALFRFVSREMRVTDPFAVLRPPAARSVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T082</accession>
    <name>A0A7W7T082_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31624" checksum="A05194DE31D8608E" modified="2021-06-02" version="1">MPRGDSPTLRKRRLVGELRRLREAAELTIEEVGERLECSASKISRIETGRVGVTPRDVRDMLTIYGAGPETLAELVQLAREARRKAWWDEFGDIAPGRYVGYEADAESVRIFQGLMIPGLLQEECYTRALIAAVLPGASAKEIDRRVQLRKARQALLGEDDPLKLSTVIDEAALRRLIGGSDVMRAQLRRLVDASERENITVRVHPFTSGGHSALDGRFVILRFPELTDPDVVYLESFKGDMFLENSEDVSRYSDMFARLVAESLEPAESVAMIERVARELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T094</accession>
    <name>A0A7W7T094_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="25614" checksum="80C266DA504BE6C2" modified="2021-06-02" version="1">MSDRTARRRTAARRRPSGGLPTRATALRRRAVALLTALTVIGVVVVVWFTPTFGVREVAVDGLREMNADEVRAAAAVADGSPLVRLDVEGIASRVRALPRVGGVTVERELPGTVRLTVDERDPVGVIKATDGVHLVDETGKDYATVAQAPIGLPELKLGGDDRALVAAVGVLIRLPDSVRTLVQTVSATTPADVTLHLTEGREARWGTVDDTPRKADVLLVLLTRKGSVFDVTSPELPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M0</accession>
    <name>A0A7W7T0M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="5925" checksum="9D53F93DD2A38DB1" modified="2021-06-02" version="1">MSFEVPLPGPPRDPVAGIDDAVAGLDGLDPLAVDEHVSRFDEVHTALTAALSSIDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T103</accession>
    <name>A0A7W7T103_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system N-acetylglucosamine-specific IIC component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="11">
        <location>
            <begin position="14"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="44907" checksum="37940C3DF44402C5" modified="2021-06-02" version="1">MSANAPQATGGRDIKGLAGIQRFGRSLMLPIAALPVAGLLLRLGQPDLLGDKGWGWTKVAAVIGASGEALFANLPLLFAIGVAIGFARRGDGSTALAAAVGYVVTTSVFKAIAPFVLPVKEGAKQQEINYSVLVGIVVGLITATLWQRYHRVKLPPYLAFFGGRRFVPIIVAGVMIPVSVVLGLIYPWFNKGLTWVGEAISGSTIIGAFIYGFVNRLLIPLGLHHIPNTFMWQVFGEYQGKTGDIPRFFAGDPTAGTFLTGFFPIFMFALPAAALAIVHTARPAQKKIIAGIMGSAALTSFITGVTEPLEFAFMFVAWPLYVIHAFLTGTSMAVSNALGIHDGFGFSAGVIDYIINFNIAQKPLLIILLGLIYAAVYYFLFRFVITKWNLRTPGRAEDEDPEADPSVVEGAEKPANGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T121</accession>
    <name>A0A7W7T121_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030846140" evidence="2">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="18559" checksum="E4150BC63BD28C3D" modified="2021-06-02" version="1">MSRTPGRALLACVTLLAAAACTTAQAGTPIPVRGAAPHEPVPSTPPPTSGTTKAANKNPCDLLTADEVGTLGLNHPGVLKQVDRVDTCSWNVSGNGGLAASVEPGLDSLRLEGKRVAPTRYGDHEAVLVEGSFGQDYACSVAIAVSDDIAVLIIANLTASAKDTPAACARATKAAELIEPKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A3</accession>
    <name>A0A7W7T1A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="6240" checksum="4E19D90796E4A091" modified="2021-06-02" version="1">MSDSRIGEYRLRRRHAGVGQVRRPDAADLAVADAFGVADRLRPVFRQRWTVDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1J3</accession>
    <name>A0A7W7T1J3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="46" mass="4761" checksum="1CF63EDC8F2956DB" modified="2021-06-02" version="1">MVQPHPPDPVPPVPPPLPDPVPPHPEPGPDVEPPLPPPPVPPTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T9</accession>
    <name>A0A7W7T1T9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome accessory factor B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="148"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="36323" checksum="AD3E67C1FD8531C4" modified="2021-06-02" version="1">MATARAERLVNLVLCLLSTRQYLTAERIRSIVPGYAEAASDDAFFRMFERDKTELRDLGVPLEVGRSDVFDGIDGYRIARRDYELGDIDLEPDEAAAVALAARLWDSPQLTGAVHGALLKLRAAGVDVDQDVRVPVEPKVRATEPAFPPLLAAVQQGRVVEFDYRRPVPAEVRTRTVEPWGVVAWRGRWYLVAHDRDRAAPRCFRLSRIVGDVRPVGKAGVVRRPDDVDLLGFVATNIRQADPTPATARLWVAEGRAHGLRRRAKHVGRREFDGEWGDLLEIALRFPDSAASWIAGFGADVVVLEPELLAKTVREKLLGAVRGAGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V3</accession>
    <name>A0A7W7T1V3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DME family drug/metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="114"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="25566" checksum="7AD8CEF24BF7033D" modified="2021-06-02" version="1">MSAFAPTTAPRVAIGAAALAVGGVLLFLTSPGTREVLRDADRRLLAVGAVTVAGYASAFYPAVARTGVAVSTTIALATAPILLGARARPVVTAVAVVGCATLVLGAGGARLDLLGVVLALVAGLSYAVYPVATGKLIAQGFPARAVVGTMFGGAALVVWPIPVVLGLSWLTTPGGLAVVAHLAIVTTFTAYLLFALGLRHTSAAAATTLTLAEPAVAALLGVVVLDEHLPPISWLGMAVLTAALFALTRESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X9</accession>
    <name>A0A7W7T1X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S12 methylthiotransferase accessory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="54"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="429" mass="46282" checksum="648FFA6257717A5F" modified="2021-06-02" version="1">MSTDLLVDPLTGLVRRFVDVAPVPGVPRRYRAVTAEVADARRLGAWPADRVSLGTTFGDVDAARAAALGEAVERYCGNRIAPGLRYATAAALRGERHWGPDELSFFAPWQHETPGFPYRPFTADQEIAWVPAEEDGEPCLLPASWVYLNYHSGARRREPRLHHLNYAGIATGVSAEDATTRGLLELVERDALERWWHQGTPTTGIRVADVPGLAAELAGCPLEVHLVELPTPHPVSCVAAVVVDPATGIVAGGGAARFDPVDACAKATLEAVHTWVFTQGLLDPDGWVFRSIDAGLLARGLYLDHRPDRRYRDDAGEGYANVRDLGAQVQVWLDPRVQDGLLHRFTAPDRFVTPEPGGTLADLRASLAASGVRVATADLTTPDVAEAGLSVIRVCALGLIPNAPAAFRYRGLAGWDDHDAFVSDPPPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T245</accession>
    <name>A0A7W7T245_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13768" checksum="D42AD52ADEA5FF74" modified="2021-06-02" version="1">MSGREDWWYDEAAGPLVRPYAMVRGRTRPLRPELHLVTQVRAMPSPADPEALSVEHLEIMELCRRPLSVAEVAAYLDVPLVVVKVLLSDLIQRGDVVIRDPSRVPLVPDRNLLQAVLDGVRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2I5</accession>
    <name>A0A7W7T2I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellobiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031004675" evidence="5">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28058" checksum="42EA6D7CC7DA1FBB" modified="2021-06-02" version="1">MIVRRAVLAVVVVASLFPLYWAVVVASHDNAAMSARVPPLLPGGELGRNVDAVFEAVDFGAALGNSAIVASTVAVATVLLSTLAGFAFAHLRFRGRRVLFGLVLGSVLVPGQLGVVPLFELVAGLGWYGRLAAVIVPGLVSAFGVFWMRQACLEAVPCELVDAAAIDGCSLPRTWWHVVLPAVRSQALVLGAVTFLAAWNDFLWPLVALDPVESPTVQVALSHLAGGYFTDYPLVLTGAVLGTLPVVVVFALMAGKSLTGLLRGRVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M3</accession>
    <name>A0A7W7T2M3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9669" checksum="8873C6FAABA2AFFE" modified="2021-06-02" version="1">MLEMGVSMSEERDTWEIRIGVHATEEQVRELIEKIKLLLCPVPEHAGPCPVPWATGLVPRDAFPDGYGYPELEEQFRIEHGHDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R4</accession>
    <name>A0A7W7T2R4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450/3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="4">
        <location>
            <begin position="232"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="747" mass="79863" checksum="D04685F4B318D58B" modified="2021-06-02" version="1">MIWDDVFIAGTGHHLPPRTPATEAVPDTDTMRRLLALSDFTSFTHSDDVTEHGMAVRAAIGALKQSGLTGADIAMAAYAQMDSQDHMAPSCHLQRVLGLGHALVYEVEATSNGGSAALQAAAAHLVADPSATATLVTATARFRPPRWERWQPTIGIFLADGAASAVLTRDGGRARLLATANGSATQMEVLAVPSIPDPQGHRDRTPIEVTGLAPYLTLMSEALVGAVERAAKEAGVALGDITRFVITGLGLAQLQVVVLEPLGISLDRTTWPFLRELGHVGPCDQLLGVDHLLNHPSTRTGDTIMVIGLGMGSRFTASLLEVTEPPRRGTTFVTESVEIPAVERYGIDAAGADIFGEAARLRERGAATPVELPGGIGAWAVTGHDAVKQVLLDPNVSKDANRHWPAWRNGEIPPDWPLIMWVAMKNMFTAYGDDHTRLRKLVAKAFTARRIEATRPHVEAITAELVDRLGTVPPGTTVDLRAEFAFQLPIRVISGLFGLSERTGADLRRLVEAVFSLDADPAGVRDASAELYMLLKGLVAEKRAEPGDDLTSDLIAASDDDGNRLGEQELLDTLLLTISAGFETTVNLLDSAVHALATHPSQLGLVTSGVADWNDVVDEALRWQAPVPNLPLRYAVEDVDVDGVRIAKGEAILVSFGAAGRDPARHGANAEEFDLTRPSRRDHLAFGHGVHFCLGSPLARMEAVTALSALFARFPDLRLAVPSADLEPLGSFFTNGHKTLPVVLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R7</accession>
    <name>A0A7W7T2R7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="175"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="39909" checksum="06F0374ED47ABF7C" modified="2021-06-02" version="1">MFRTYGFLSTYPPTQCGLATFTAALLRHLIAAAPGSEGRVVRVLAEPDPDPDVAGGTPVVCRMAPGAIEDAASSLNDCDVVVVQHEYGIYAGRDGDDVLGVLARLRVPVIVVLHTVLTAPTPGQRQVLDEVVGNADAVVTMSEAARQRLVAGYAVARPDGIVVIPHGALPAARPARRSPTDRPTILTWGLLGPGKGIEWAISALGALRDLEPRYLVAGRTHPKVLAHEGEVYREKLRDHATALGVADLVEFDPGYHEVDALAELVDRADVVLLPYDSSEQVTSGVLVEALAARKPVVATEFPHAVELLADGAGLLVPHRDQAAMTAALRRVLTEPGLAAGMSDRSARLASALGWSAVARRYRDLAEDLLTARVAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W0</accession>
    <name>A0A7W7T2W0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031434168" evidence="1">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="11814" checksum="D4944A628F9F41FA" modified="2021-06-02" version="1">MTRSRLVVLAGCAALATTALVTPAAGADATALGRVYVQANYAGSNGTWVEVCDMERDGNGVYGLFWVNGGSKPTELWDGSGSSGGCGNATYGSVQKFRVCEDVVGLDICSSEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W2</accession>
    <name>A0A7W7T2W2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid CoA ligase FadD22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="395"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="486" mass="51883" checksum="40D0C148D9D36F05" modified="2021-06-02" version="1">MTANLAGYLASRAAENGWSARPAYYDGDDVHTFEDVHRGAARFAAGFAARGLARGGRVLLALPDGIDAVWAFLGAARLGAVAVPVNSTLHPDEIALATRVAQPDLVVAEADLAGLFDAVVDPAELRAVTDEAPVADVTADDPAYAAFTSGTTGDPKLCFHTHGDPGVYEQAIGEVVGITPRDVTFSVSRLYFSYGLGNSILFPLHRGGATVLSRERATEDEALRLVRRHGVTVLYGQPSFFARLLRHPDHAALSGLRLALVAGEVLPESLESRLREVLGGRLLNIFGTTEIGHALVANTPDARRDGSIGRILPPYRLRIVDDNGDEAAPGVEGRLEVAGPTIALGSRRGGDGPLRAEGWYATGDAATVDAEGFVRLHGRLDDIEIVGGQNVHPTEIEDLLMQHPDVQEAGVCSTRRETGVTTLRAFVALKADGPSPDRVRAELLATAKEKLTWYKVPEDVVFVTALPRTPTGKLRRREVRTMAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W7</accession>
    <name>A0A7W7T2W7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF2236 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="454" mass="50305" checksum="A37ABEA204C1D006" modified="2021-06-02" version="1">MVALPGPGSATWENLGLWRQLLVTHRTLVLQAAHPAVGAAVSRFSVYNARPWRRLFRTLESLQTYVYGSASEQRRELARLERLHRRMRGTDEHGRAFDAADLAARAWVHLTMFEAVLTMRRLGGDPLPADETERFYAEWRRLGQVFGLTEADVPATAAEFAAHFTRTVAEVLEDNATVRDLLSGSIHRVPPPPGLPIPAPLWSPLRHVVVTAVVQATAATLPEAYRERLRLTVLPGADLLVAGLHQAARLASALLPEPWRYLPRASTSIRAAATPRRPDRTPSPESFFTTVLDQTGDGVLRWSDLLALARELSTHLDLDGDDEDAVHTAFESWWDQLRTATGTARDGAVTLDAYLTALADDRYPGPPDPRTGYGAVAGAIRRLIDRDGDGEVRLDEYAKLLDDSPRRHELVAALRDLDRDGDGTVHVDEFEVALQDFLAGRRDLDAARALFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y6</accession>
    <name>A0A7W7T2Y6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="42299" checksum="44B23E114A37688C" modified="2021-06-02" version="1">MTGTWRQFRSLPGSVRLLVVNQFGINLGFYLLMPYLANHLSAGLGMAAWTVGLVLGVRTLSQQGLFLLGGALADRLGYRPMIIAGCALRTVGFALLGLVDSLPALLVASAATGFAGALFNPSVRAYVAADAGPRRVEAFAVFNVFYQAGILVGPLVGLALTALDFGAVCLVAAAIFAVLTALQVRSLPARGGGAEASAGVLADWRTVVGNRAFLLFSLAMISSYVLSSQIYLALPLQAAHVLGVTAGDAGSTALFAVSAVVAVFGQVRLTEWVRARWDAGRAVAGGLGLMAASFVPLVMTAGLTGGAWALVPALVTTVLLTLGTAIAYPFEMDTIVTLSGGRIVATHYGFYNTLAGVGITLGNLATGWVWDVGAATGFPALVWIALATTGAVGTGALLLLNRTTARREAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T319</accession>
    <name>A0A7W7T319_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="198"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="41943" checksum="4A7953B1124C7F72" modified="2021-06-02" version="1">MRANTRAGRNKVEVRDVPDPRILNGRDAIVRITSSAICGSDLHLVDGHVPTMQDGDVLGHEFMGEVVEVGSGVDPARLRIGDRVVVPFPIACGACAACAAELYSCCENSNPNAGIAEGMFGHPVAGIFGYSHLTGGFAGGQAQYARVPFADVGPLKIESDLADEQVLFLSDILPTGYMGAEMCDIQPTDVVAVWGAGPVGQFAMDSARLLGAAQVIAIDKEPCRLAMAERAGHTPVDFDEVDVRSRLLELTGGRGPDKCVDAVGMEAAHGSAHISAYDRVKQAVRSETERPHALRQAILSCRGGGVVSVIGVYGGLMDKFPAGAWMNRSLTLRTGQCHVQRYMKPLLERIERGEIDPTRIITHTLPLDEAERGFEIFKNKQDDCEKVVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T358</accession>
    <name>A0A7W7T358_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15110" checksum="289E47E36A403669" modified="2021-06-02" version="1">MVTLRAWFDGDSDDPTIVTTAAELDAVLDIVVGWEDPILVALYVQDDILRAVFEVGLNGGKGVGVVYYSGDETGWFSRSSQPSNAETILYYYMDNDHEYPPHSEVPIDVARQAAHEFMTTRGERPTGVEWQKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T435</accession>
    <name>A0A7W7T435_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="24060" checksum="F729A488C58AF59F" modified="2021-06-02" version="1">MSRSVLVTGGNRGIGLAIAQAFAARGDKVAVTHRGSGAPEGLLGVKCDVTSTAEVDAAFTEIEAAHGPVEILVANAGITDDTLLLRMSDEQFTRVLDANLTGAFRVAQRASKNMLRARYGRIVFISSVVGLAGGAGQVNYSASKAGMVGVARSISRELGTRGITANVVAPGFITTDMTDALPEERRKQILAQVPAGRYGSVEEVASAVTFLASDQAGYITGAVVPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T437</accession>
    <name>A0A7W7T437_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="33681" checksum="1361A7B5072BA330" modified="2021-06-02" version="1">MEQRHLGRSGLRVSRLGLGTMTWGRDTDAETAEALLIAFTEAGGTLVDTADVYVEGESERVLGRLLAGIVPRDQVVVATKAVARRDDGPFGGGASRGALLAALEGSLRRLDLDHVDLWQLHAWDATVPLEETLSAVDAAVTGGKVRYAGVSNYAGWQLGTAAALPGHTPIVSTQVEYSLLERGIEREVAPAAEHHGIGLLPWAPLGRGVLTGKYRNGTPADSRGASTHYAGYVEQHRTDRAARIVQAVATAADGLGTSPLSVALAWVRDRPGVVAPIVGARDATQLAGSLAAETLTLPPAIRAALDDVSAIDFGYPERPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T464</accession>
    <name>A0A7W7T464_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine phosphatase RsbU (Regulator of sigma subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="301"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="540" mass="57091" checksum="B395F709D106D118" modified="2021-06-02" version="1">MDIERSGVPQAAVGRGWRHAPYPSLVLDREGQIRAANESAHTLIPRLADGVLTAVDWVGHAHEKFARGVRFDAPVSGSVGTRSFEAHPVGHDDGSVTWWLVEDTDARLAREALRLERDRVALLGDVSSVLLTSLNPERCMMITASLAAEHLADAAVVVGIGSARRDVPTTRCVRGGTPESRRFDVDVDAVVGLGEAMRGYPPVPSRWIDPAGAPAWLVPDGFGPVGSMVITPLPGHGVPAGALVLLRRVGGPAFSEDEEAFARLFAARAGTATSSARLFSQQATITETLLRDLLPPTLRRVDGVEYAGRYRPSPDTERVGGDFYDVHALPAAGGRAEVLAVVGDVSGKGLEAAVLTGKIRTTLQALLPLADDHQRVIDLLNGALRSAHHTRFATFVLASVSRIGRHVRLRLTSAGHLPPLIVRADGEVRSVPTTGTLVGVLPEVPCTSVDVALAPDDTCLLYTDGIVEARGGALGDGVFGEDRLRRALASCAGMPADAVAEHVHLVAEQWSGANGHDDMALLAITSPRGGHPSDEPGRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E4</accession>
    <name>A0A7W7T4E4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF418 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="228"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="394" mass="41841" checksum="0694F83E4F59FCCD" modified="2021-06-02" version="1">MTASVAAIRNRVQDLDAVRGLALLGIFIVNITFMSSGYPGNLVTDPEYSSVFDNFVRGLSSVFIDMKFYMLFSFLFGYSFTLQLEAAKRAGAAFGPRMLRRIGGLFVLGALHTAFLYGGDVLTTYAVACLVLFWMRNASDRTALRVAAIVYGVVLLIMVASGLFVDSSTYLPGEAEALANGAHATQAMLGGWGDVIDHNLGGLVLLIAQAVSFQGPASLALFLLGMVAGRRRLLANVRGDEPILRRLQLIGYPIGIAGGLAFALGGGAGTGLASAASVATAPLLTAAYVATLLRMMHSPRTEFLRDTLAPAGRIALTNYLGQSVVGLVLFTGVGFGLAGSFSPAATMGLAVLVFAGQVAASAWWLRHHQYGPAEWVLRWVTNARRPAWRKAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F9</accession>
    <name>A0A7W7T4F9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="14050" checksum="37F9C8C67047FEE2" modified="2021-06-02" version="1">MTLFLWFILLVGPHPRIEIRERGLVVVNWLSRTSIPWTAVESVEADGALELRLRDGRVHRPIIASRSLATVLSGDRLQNEMKAAVVNAESAVPDGDSRARTRPDLWLGPLVLVYGTFLLIGWLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I5</accession>
    <name>A0A7W7T4I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="14"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="33600" checksum="AAAD2848E08078A2" modified="2021-06-02" version="1">MSVLGRTGLAVSAVGFGSWATGGPGVMGWGAIDDDASVAALHRAVAGGVNWVDTAPVYGFGHAETVVGRALAALPAADRPLVFTKCGLVWDADGVESNNLTPESIRRECDASLRRLGVEHIDLYQIHDPDPTGPPIEESWGTLLDLVDAGKVRHVGVSNMDVGLLERCEAVGPVETLQPPLSLIKREAAGDVIPWCARRGVGVLVYSPMAAGLLSGAFTASRELPADDWRSRNAEFRSPALERNLALQDALRPIADRHGVTVGAVAIAWTTSRPGVSTAIVGARSPEQVDGWLPARTLALGPDDLAEITAAVHATGAGRGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q6</accession>
    <name>A0A7W7T4Q6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12721" checksum="D37066BF833A01A3" modified="2021-06-02" version="1">MGLFGVDEARAELERLRPVLDEIVVIRADAAELSAALADGVVTDLGGLPEFKAAQARLDDLMSTVQATGAELKGFAPLLVDFPAELDGAPVLLCWLEGDAGLDWYHRADLGFAGRRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T530</accession>
    <name>A0A7W7T530_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7010" checksum="C22617E879FD76D4" modified="2021-06-02" version="1">MNRTRGEQTDTRHGATKTLLWLVLLVTAATNSIGSFVGLHEVLRLAAGGVSVLCIVGLVVLHMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T589</accession>
    <name>A0A7W7T589_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queE</name>
        <name evidence="7" type="ORF">F4559_004193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="30"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="26144" checksum="ADDE8E2B6A8D46FC" modified="2021-06-02" version="1">MNTLTLAPERVEGSAILTEKFESFQGEGPWTGQRCVFVRFSRCNLRCSFCDTPESWDWSRYNPAEVSDRVPVTELVSWVRERGVDMMVITGGEPMLQQPAMTALARGLADIRVQVETNGTVAPTPELASLVDLWVVSPKLANSGMTYSTRIKPEALSALVATDRAVFKFVVTEPDRDLDEIAQLVEEHRLTPVWVMPEGTTREKVLAGMDALYDRATERGWNVSTRLHILTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B5</accession>
    <name>A0A7W7T5B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29851" checksum="7B09269770D1D706" modified="2021-06-02" version="1">MAKSIAFSAIAPPDYLDAFVAQEPATVHHVAAQRVLTDAAYRAFFHREAQRGAEIIVDNGVFDLGHALPAADLIAAARIVDAREIILPDVMRDGLATIKASDEAAREILDLSDEFRLCVVLHAADDHEWLRCYDYFASSDYVGAIALPASRRPAPEDQLCRTRWAATRYLEDHGMVEDRIVYRLLGLGRTGHLELVEQREHEWIASVDGAAPVILGAMGIEMLPDGPYEKPPTPRIEDLGPIPEERFGLIRRNIAVVREAAGSSVRIPEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H7</accession>
    <name>A0A7W7T5H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35592" checksum="43EB93CD51B6F6CC" modified="2021-06-02" version="1">MDRDQPDDDTMKAAIALACRAPSVHNTQPWRWLLGDRTVHLYADVDRHVPATDPTGTDLLLGCGAALHHLRIALAALGWAAIVHRLPDPARPDHLAAVEFVRREPTASDVALAAAIPRRRTDRRRYSSWTVPPAVLAQLGDRAADEGAIAHAVVEPEERFELAAALGFAAALQDADPAYRWEVRTWSGRHADLDGVPAANAPVGVPVHGDLRLREFPGGELRDVPAGDWEEDGASLLVLGTSSTDALSTLRAGEAMSAVLLEATAAGLATCPLSQALEVDETRDRVRRRVLHDTLCPQIVVRVGWPAFNADPLPPTPRRPPSEVTGGLEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N3</accession>
    <name>A0A7W7T5N3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribose pyrophosphatase YjhB (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="16947" checksum="20FF606C7FF95CD3" modified="2021-06-02" version="1">MADRGGPERLTADVVLFTQQGGVWSVLTVERAKEPFLAALALPGGFVEPGERVPEAAVRELAEETGIVVPTRRLRRLGLYRKRGRDPRGPVATVAFHSYSPGAPEATGGSDARAAGWIPVTDLLSEAMRVAFDHRDIVRDAVIRRFGRVPQPVGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q5</accession>
    <name>A0A7W7T5Q5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="704" mass="75640" checksum="B74B981998B52EBA" modified="2021-06-02" version="1">MRKAEYVNTVSGSVHGQVLQAHTVTADTIVLHAPEHRVPVPRQLPPPARIWVDRAGEWERLDRLLTTAGPTRVVVTGLGGVGKTGLAVRWLDAHHERHADGVLYVDLNGWSGHPPPTASQVLAGWLRALGVAADDLPGEADELVALYRTFTADKAVAVLVDNARSAEQVQPLVPATARGTILVTSRHRLAGLALAGFRHLDLDCFPAATGAALLAGLLDEDRQPPGEDFLHALAARCHGHPLALTIAGAHLAAHPRRDPARLVTRLSHLAEASAASDPHELSVEGVLQMSYEDLDATTARLYRGLAEHPGAEFTAGPLAAGLDVSISAVDRGLGRLVEANLVTETGDERYRLHDVLREHVQAIADQDDQGERLAVRRRMIEWYLRRAAAADKVINPFPRRFSDVYADLDTGVFDDAKAALDWADTERANLLAAQQVAADQGWTELVYQFGEALWNPLRPNYTAGELVRSQFLGANAAADAGHILEVVCHTRQGFGLTNFGHHEAAVDICTIAVERADEVGDPWLQSGALSTRARAHLKANDPHAALPDLQRSLSIAEEMNDARSIALRHRRLGETALHPKIADARLAVHHLRLAASMFTGIGDDIGHARTVLHLARALTLNGQAAEALSELAAIEQAVHDYGSVGYLADLCAVLGEVHAALGDTAQADRRYGEAIDYYTAAGPGADKSKAAVIDRRAALDQPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y1</accession>
    <name>A0A7W7T5Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="387" mass="40686" checksum="0A464B9B6B2D0D8B" modified="2021-06-02" version="1">MTGFVESEERRALRAAVRDLAAEYGPEYFVAKARAGEKTDELWRRAGALGYLGVAVPAEYGGGGGGIGDLAAVCEELAAGGCPLLLMLVSPAICGTLFARFGTPAQKDRWLPGFADGSVRMAFAITEADAGSNTHRLATTVRRDGDGWVLSGAKQYISGVDEARAVLVVAAHAGHAVGSRRRLSLLVVPTDAPGFAYRHIPMEVVSPEKQFSCFLDDVRLPADALVGAEDGGLAQLFAGLNPERIMAASYATGMARRALDQAAEYARTRSVWDTPIGAHQGIAHPLAHCAIQVELARVMTQKAAALYDAGADRAAGEAADMAKYAAGEAVVAAVDQAIQVHGGNGLATEYGLGAMLAASRLARIAPVSREMILNFVARHTLRLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z2</accession>
    <name>A0A7W7T5Z2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="29160" checksum="0D6A55D27B2BEDA0" modified="2021-06-02" version="1">MGDVTGGVGLTALGAAAARAVETSRPDRLAEDPFAAAFVEASPIPVPFPVRWPEDGEELTDRQRVLLSGANYVGLRTRFFDDVVHGARQVVLPAAGLDTRAFRLDWPADAHVYELDLAGVLAFKDAVLTVAPAATRTTVAADLATDDWAAALLGTGFAAATPTTWIVEGLLQYLSADAEVAFLAAVDGLSAPGSTLAVERSVALSAEALRAGGARAGVDLSKIAHAGARPDLAAWLADHGWTTEDHPVGEVAARYGRPLLHPRLAAGSAAPSPAGFTVATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z7</accession>
    <name>A0A7W7T5Z7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF418 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007349">
        <property type="entry name" value="DUF418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04235">
        <property type="entry name" value="DUF418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="DUF418" evidence="2">
        <location>
            <begin position="204"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="370" mass="39775" checksum="7C2F858576BDF76F" modified="2021-06-02" version="1">MGRIVALDVLRGVAILGTLGTNIWIFTDPAGPSGFFAGGGTAETALTALSNGKFLGLLSILFGIGLAVQHRSAVRRGTRWPGRYLWRSTLLLVEGALHYVLVFEFDVLMFYAMVSVVVAFLVGRPDRVVRRWLVAFGALHLAVVGLLTVVLMGAGDLGPPTATYPTDSWTAQVATRIELIGVFRAEGVLVLPLSTVLFLIGILLFRAGALEDSVRGRRLQHRLALAGLGVGLPLNALSAFAPGQWFLVDRYVCAPFVALGLLGAITALVHRMGEPGPIRTGLTSVGRTALSCYIAQNVLAAALCYGWGLDLTAAFGRFGAAYTVAVWLVIATFLLVAATWWTKRFRRGPVEWVWDLAYRAPGRRRVASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z8</accession>
    <name>A0A7W7T5Z8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF427 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25874" checksum="FF5C764DA8CB14C8" modified="2021-06-02" version="1">MSETIRLEEGAKRVRAFLGGVPAADTTRPVLVWEKPYCPTYYFPAADVPATLTPTGETRDGAVVHDVTVGGTTARNAALTRPEPELRDLVRLEWDAFDEWFEEDQPVYVHPRDPYVRVDALPSSRHVRVVIDGVVIAESRRPVVLFETGLPPRYYLPLADVRQEVLRPTATTTSCPYKGTASYWSAVLDGRVHEDVAWGYRTPLPESAPIAGLVAFYGGRVELHVDGRRVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6G2</accession>
    <name>A0A7W7T6G2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010317">
        <property type="entry name" value="DUF916"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06030">
        <property type="entry name" value="DUF916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030711760" evidence="2">
        <location>
            <begin position="39"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35022" checksum="EA80551A8A324098" modified="2021-06-02" version="1">MARVLRATPSSSWETPMPLRVLLVLVVFLLGITTPASAQESVTWGVRPAGTDGRPNYGYSAAPGDTIRDAVAIANHGDRPITLLVYAADGFTTTSGQLDLLPAGQPSTDLGTWVALAQSQVEVPARSAVEVPFTITVPADAGPGDHSGGIVTSLAVPESSGGVRVDRRLGSRVHLRVTGEEKPALAIEGLSVAYDGNPFGFGTATVSFRVTNTGNLRAGGTQTIAVEGLFGLGGRERSVSVPELLPGAGSDFTVPFADVAPLVWLDASVRLVPQVAGGGALAEVTAETGTWAVPWVALLVLVAVAGLVVVLRLRARRRRAATDRRIAEAVEEALTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6V2</accession>
    <name>A0A7W7T6V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein YqjE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13698" checksum="372758BA5F57A233" modified="2021-06-02" version="1">MTRVQEASTAELVGRLSEQVSRLAREEMRLAVAEIKEKGRHVGIGAGLLGGAGVLAWFGVGTLIAALVLTLALAMPAWSAAFVVTVAVFAVAGVLALIGRRQIARGTPPVPEEAIESMKADISTVSERAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W8</accession>
    <name>A0A7W7T6W8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recX</name>
        <name evidence="6" type="ORF">F4559_005045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28494" checksum="9BE2FE8054CB4578" modified="2021-06-02" version="1">MGKLVDEFEDDGSDHGRDDDPWAAVAPGTAVSVPDPTARSDSRDEDDPWASAVPGVGSSPRRGPAAEGEGWARADRRATGKSTSDSHGRRAAPEADGEVDPAAERRRATDICYALLTARARTRVELRDALARKGIGPGTAEDVLGRFDRAGLIDDAAFAEVWVRSRHTHHGLGRRALARELRQKGVSDEVAAEAVAAVDEDAERERARELVRKKLRAMSALDDRTKLRRLVAALARKGYAEGLAYRVVRDELQDVDDEPFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W9</accession>
    <name>A0A7W7T6W9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PglZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013973">
        <property type="entry name" value="PglZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08665">
        <property type="entry name" value="PglZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PglZ" evidence="2">
        <location>
            <begin position="490"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="898" mass="95830" checksum="43174403C9A9F917" modified="2021-06-02" version="1">MVAPPEVNRRIVESLLEAELPHAGDRRLVLVHGRYDESSPSEFALRVGGRQRRVTVTDQRSVLGIVDAWRRHRVGADTDDVLVVTTGVDDAQLGWNLRGHAVGRATRTVDRAEIVKQRFGAVDIDPRIRRERWLVDALLAAEPAAGWRRSGPVLTRDTAVRALIGARVGGTELAEGTLDASSLLSWSRTAAGSAFAALPEAEQAGLSSWLVENVGAAAVVVMSLAAAGQADDVMALGVLASAIAGPNASTDAALAIGGLLGRVRPRGNELQAFVDAVEGVLDRWAGEAATGTATGQETRRQVLDVVRRADDLAVSADLTASLTANRFLPSSFDARLRDLAGALARGPHNAADTALRAVEEHALARLFPGRAAAAATAVRLARWIAEPEDDVESVASGVRNHLADWAWVDRALALLWMGDSVHDPVVGQAYRSVHDAARARRDRLDERFAKHLAVWTRHASTQDTGGCLVIEDVLGQVVAPLAGGHRSPLMIVLDGMSGAVATELGEQLAARGWEEVSPEADTRVVAVAAIPSVTRVSRASLLTAGLASGDQSSEKSGFEAFWRRHRRTASLFHKGEIGGHAGQRLSDDLVTALAGDEIVGVVLNTVDDALDHGREGDRTGWRVGDVTYLADLLDAARAYARPVVLASDHGHVLERTEPGSGPIDAPGVESARWRTGTPREGEVSLTGPRVLDGGGSVVVPWREDIRYTPRKAGYHGGASLAEMAVPVLVLLPSVDLMPTGWHLLCPEAVTPAWWRRPVEAATPAPAQRRRPQRAEPRADERSTPLFPVETASRDAETLGRRVVASKIYDAQKEYVPKAPKKPEVAAVIDMLAAADGTRSLTSVATAAGRSGRNPEFLVSTLQRLLNVEGYPVLSSVDGGRTLKLDLELLCEQFGVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X5</accession>
    <name>A0A7W7T6X5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent Lhr-like helicase</fullName>
            <ecNumber evidence="5">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005052</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="30"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="896"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1548" mass="165800" checksum="249C3EF7EE25F18F" modified="2021-06-02" version="1">MNVLDAFSPATRQWFAGAFAAPTAAQAGAWEAAARGEHALVVAPTGSGKTLAAFLWALDRLASAEPPADRERRCRVLYVSPLKALAVDVERNLRAPLAGIRQAAHRLSLPEPSIRVGMRTGDTPADERRAFTRTPPDVLVTTPESLFLVLTSRARESLRGVETVIVDEVHAVAGGKRGAHLALSLERLDALLERPAQRIGLSATVRPVEEVAAFLAGGRPVTLVQPALAKTIEVRVEVPVEDMSVLGEPTGEVSGSAAGAERRASIWPAVEQRVLDLVRAHRSTIVFANSRRLAERLTARLNELAVESENPSGTTDFDRTVVSDRSPTVEPGPGGRRTSRSSTERFPAEAVGQSGVTTQSGAVIARAHHGSMSREQRTVVEEELKSGRLPCVVATSSLELGIDMGAVDLVVQVEAPPTVASGLQRVGRAGHQVGAVSRGVVFPKFRGDLVSCAVVAERMRDGAIEAVRYPRNPLDVLAQQIVAMVALEPWTVDALAGLVRRAAPFAALPESALRAVLDMLSGRYPSDEFGELRPRITWDRVTGELAGRPGAQRLAVTSGGTIPDRGLFTVTTPPSENGPGSRVGELDEEMVYESRVGDTFLLGTSSWRVEDITHDRVIVVPAPGQPARMPFWKGDSPGRPLELGRALGKFLREVSAADAREAARRTAAAGLDAWATSNLVTYLTEQREATRHVPSDRTVLVERFRDELGDWRLVVHSPFGAQVNAPWALAIAARLRERRGVEVQAAHSDDGIVVRLPDAVDQEGVPVVVGAADVLLEPEEVEQVVVAEVGGSALFAARFRECAARSLLLPRRDPRRRTPLWQQRQRSAQLLSVAAKYESFPVVLEAMRECLQDVYDVPGLRELMAEVRARRVRVVEVETSSPSPFARSLLFGYVGMFLYDADAPLAERRAAALSLDSALLAELLGTEAIRELLDPEVVEEVERALQRLAPDRHVRDVEGTADLLRFLGDLSPAEAAERGVRPEWIDELVARRRVIRVRIAGQDRVLGIEDAGRVRDALGAALPVGVPEAFTEPVADPLGDLLSRYARTHGPFPAAQAAERFGLGVAVVTGVLDRMAGTGRLVRGELRPGGTHTEYCDAEVLRRLRRASLARLRSEVEPVEPAALGRFLPGWHGIGRRTRSGPTVDDVYSVVEQLAGAPLPASAVESLVLPARLPGYSPALLDELTASGEVTWTGCGALAGGDGWIALAPTDVADLLLPDLVPEAVPESSLHTAVVEALAGGALFFRQVVDRVSLHGPTTDAEVVGALWDLVWAGVVTNDTLGPLRAVVAGGGTAHKPRRSAPRGRYARMRAARPDMPSRTGPPTAAGRWSLAVVPSTDPTRRAHARAEAFLERHGVLTRGALDTERVTGGFSGVYRVLRMMEESGQVIRGYVVEGLGAAQFAARGAVDRLRALSRPAASTTPDPDAATAVVLAAADPAQPYGAALPWPAQIGESKHRPARKSGALTVLVDGVATLYVERGGRSLLSFTEEEEPLRAAAHALGRAVHDGWLGSLSVQKADGEHALSSNLSTILQEAGFRATPKGLRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7F9</accession>
    <name>A0A7W7T7F9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="86"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="44480" checksum="A4BB8EFC6A206F68" modified="2021-06-02" version="1">MTAVSVPSATTSFDLGPARALSCRECGNETPLAPEYACYECFGPLEVAYDFGRVRREDIESGPQSIWRYRSLLPVPTNVASHPNLEPGNTRLIEADRLAKALGLRKVWVKDDTGNPTHSFKDRVVGVALAAARELGFKVLACPSTGNLANAVAAAATRAGWQSVVLVPSSLEQAKILMTAVYDGALITIDGNYDDVNRVAQELAAENEDWAFVNVNVRPYYAEGSKTLGFEVAEQLGWRLPEQIVVPIASGSQLTKVDKAFRELGSLDLVEATPYKVFGAQATGCAPVATAFKAGHDVITPVRPDTIARSLAIGVPADGPYALDSVRRTGGTIEDVSDEEVVEGIRLLARTEGIFAETAGGVTVATAKKLVETGQLDPDAETVLLITGDGLKTLDAVSHKVGPKANVPPSAEAVINALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H0</accession>
    <name>A0A7W7T7H0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl oligopeptidase</fullName>
            <ecNumber evidence="5">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="18"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="483"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="700" mass="77132" checksum="C5454E35B16F2EA5" modified="2021-06-02" version="1">MTQAYRAALPATTTYPAAQRLDLVEQLHDHRVADPYRWLEDPADERTRTWSEQQDALARTWLDVLPGRDALERRLAELTGTGSVGTPVWRADRAFYTRRGPDEDFPVLYVREADGTERVLLDPTALDETGKTTLDRWTPSREGRLLAYQVSVGGDEHSLLHVLDVDTGEIVEGPIDRCRYSPVAWLPGGEEFFYVRRVDPELVPEDERQFHRRVWRHRVGTDPATDVNVHGDGLDHTYYYGVTLSPDGRWLLVNGAPGTVRRDSVWIADLAGDGVLRPVVTSDAGVQCSAFVGHDGRLYLRTSLDAPRFRLCVADPARPTEWAELVPEAPDSVLDGALLLEDRLVVLRTEHAVSRVDLHAHDGTHLAAVPLPGTGSIHGLVTVDPLTSHDRDTLWFGWSDFVTPLSVYRYSRSTGETVLDRAAPGAVALPSVTTRQVAYESADGTVVRMFVVAGAEGPDLPRPALLTGYGGFAVGRGPGYSASTLAWVEAGGVWVHASLRGGDEEGEEWHRAGMRDRKQNVFDDFHAAAERLIADGWTTPEQLAISGGSNGGLLVGAALTQRPELYAAVVCSAPLLDMVRYENFLLGRLWAEEYGSAAVPEELGWLLSYSPYHRVREGVEYPSVLFTVFESDSRVDPNHARKMCAALQHATASDSTKHPVLLRRETEVGHGGRSVKRAVRLAVDQLTFLAWATGLEIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N9</accession>
    <name>A0A7W7T7N9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glycine--tRNA ligase beta subunit</fullName>
                <ecNumber evidence="9">6.1.1.14</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">Glycyl-tRNA synthetase beta subunit</fullName>
                <shortName evidence="9">GlyRS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">Glycine--tRNA ligase alpha subunit</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">Glycyl-tRNA synthetase alpha subunit</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyS</name>
        <name evidence="8" type="synonym">glyQ</name>
        <name evidence="11" type="ORF">F4559_005452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="979" mass="104610" checksum="2AEE901748B85FA0" modified="2021-06-02" version="1">MLTMQDALLALTRYWTERGCVVVQPYNTEVGAGTLNPATVLRVLGPEPWRVSYVEPSVRPDDARYGENPNRLQTHTQFQVVLKPDPGDPQELYLGSLAALGIDVRAHDVRFVEDNWASPALGAWGLGWEVWLDGLEITQFTYFQQAGGLSLDPVSVEITYGIERIMMALQGVSHFKDIAYAPGISYGEAFGQSEYEMSRYYLDDADVEANRRLFEEYAAEARRMLDARLPVPAHNYVLKCSHAFNVLDARGAISTTERARAFGRMRGLAREVAKLWADRRAELGHPLGIAEVPAAPEPPAEFATVDAPATLLFEIGTEELPPAEVIRTADAVRAAVADKLAATRLAHGDVEVHATPRRIVVLVADVAPRETDTERTARGPRVSAAFDDSGTPTKAAQGFARGQGVDAADLGRVVENGVEHVAVTKTVVGRGAVAVLSGLLAEVVTGLRAEKNMRWNDPALSFSRPVRWLLALLGTTPVPVAVSALASGSVTRVHRTADEPVVAVAGADGYPEFLAGHGVTVSADARRRAIVDRATELAASVGGVVDLTGVLDEVVNLVEWPTPILGSFDPSYLDLPAQILTTVMRKHQRYLPVRAADGTLLPYFVAVANGNVDEDLVRTGNEAVLRARYEDAAFFWRADLRTPLEAMKANLEKLTFADKLGSMADRADRIAALAARLADVVGVADPTLSRAGGLAKFDLGSQMVVELSSLAGFMAREYAVRAGETEAVAQALYDMELPRSAGDDLPSSEVGALLSLADRFDLLAGLFGIGANPTGSSDPFGLRRAALGAVSVLRAFPALREITLTRALTLAAANLDVADAVETAREFAVRRYEQQLLDAGHDHKLVRAVLVHADAPALADEVLVDLTALVDDPAFEVSAAAFGRVRRIVPEGTAASYDPTALTEPAEVALHAAFAAVPKGVVGLAAFVAATSSLAAPIDAFFEEVLVMAEDPAVRAARLGLLAAIRDLAAPVLDWQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7R8</accession>
    <name>A0A7W7T7R8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(2Fe-2S) ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11558" checksum="FCA56987EBF2FDFE" modified="2021-06-02" version="1">MTVCRGCCCGTVKKYPDYDHDDQLARLRALADRSGGTVTVRTADCLDVCESSNVIVVKRPGEKPVWFGLVLHDAVLSDLEDWLETGGPLPELLELNLIRGRLGSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T3</accession>
    <name>A0A7W7T7T3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="48020" checksum="748787449597EB8C" modified="2021-06-02" version="1">MGGIFINYRTTPATTAVALVLRERLREIFGVGNVYLDRESIDAGAAYPDDLRRGLDRSQVVLALVHEDWLADLDAKTGKDWVRWELETALARGKLVIPVLVDDAVLPHEGRLSGGLRKFALAQARRVRSSDPRADADALAEELTLLVDTGFAQAHAERTGTSAPDARAWLAAVGALAGLGGLLLPVDATLVGTLLLVSLAVALVSVVVLLGRKRIRAAESLLQPMTPTEYYTRVGVPFVLGFLGLCAAEVFADGVEPVGVLVMAGIVLFAVIHMTLSLRRDRLRHEERERLWPRRLSTPVAPVALRQDLARLERHLAGHEGHDRRLPLTSRLRCRKALLGLTLGVRLLRRDSRRRRVVWALADHPVWTAVCVAWTVGVVTASRFAPVTAVLVGGAAALVGEAAFRRQRWTRDAVADEVEAHVTALRERWRTIDHRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T854</accession>
    <name>A0A7W7T854_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13418" checksum="FBDFABCE3089844F" modified="2021-06-02" version="1">MEPTRPRTWSALALAGLLGTAGVTHFAKPKAYDAIVPRSLPGEPRTWTRLSGVAELALAVTVAAPRTRRLGGLLAAGFFAAIFPANVKMANDLRNAPPRTRALALGRLPLQAPLIVWALRVRHAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8H2</accession>
    <name>A0A7W7T8H2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="655" mass="69458" checksum="5DFE3835302800E0" modified="2021-06-02" version="1">MTNRLASSTSPYLLQHADNPVHWWEWSPEAFAHARERGVPVLLSVGYAACHWCHVMAHESFEDETTAAYMNAHFVNVKVDREERPDVDAVYMAVTQAMSGHGGWPMTCFLTPDGEPFYAGTYYPPVPRPGVPAFRQVLEAITHAWEEQGDEVRASAADIVSRLEFKALPKSTVDEDALDGAVVSLLGHFDRAYGGFGGAPKFPPSMVLEFLLRHHERTGSVEALSMARSTCDAMADGGLYDQLAGGFARYAVDAAWVVPHFEKMLYDNALLLRVFTHLSRRDGKPRYADVVRQTADFLLRSLRTAEGGFASALDADTEGVEGATYVWTPAQLVEVLGLEQGAQAAARYGVTDAGTFEHGTSTLRLLGDVDPEAAARLLAARDRRPQPARDDKVVTAWNGLAIQALAEAGAVFGVGEWIGAASRAAALLLDLHLVDGRLRRTSRDGVVGRAAGVLEDYGCLADGLLALHQATGDVRWLTDACGLLDTALDRFAGAEDGVYFDTADDAEALVQRPADPADNASPSGASALASALVTASVLGAPHAARYRAAAEAAVSRAGLLVAREPRFAGHWASVAEALLAGPVQVAVVGEAPELVSAAWAGVPGGAVVVAGAPDAAPLLVDRPLVAGGPAAYVCRGYVCDRPVTGVDELVAALHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8L1</accession>
    <name>A0A7W7T8L1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline-quinone synthase</fullName>
            <ecNumber evidence="2">1.3.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Coenzyme PQQ synthesis protein C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pyrroloquinoline quinone biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pqqC</name>
        <name evidence="4" type="ORF">F4559_005874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = H(+) + 2 H2O + 2 H2O2 + pyrroloquinoline quinone</text>
            <dbReference type="Rhea" id="RHEA:10692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
            <dbReference type="ChEBI" id="CHEBI:58778"/>
            <dbReference type="EC" id="1.3.3.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.11" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033732">
        <property type="term" value="F:pyrroloquinoline-quinone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00654">
        <property type="entry name" value="PQQ_syn_PqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011845">
        <property type="entry name" value="PqqC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02111">
        <property type="entry name" value="PQQ_syn_pqqC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="3">
        <location>
            <begin position="12"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="26875" checksum="DE1A4706217815DE" modified="2021-06-02" version="1">MPEPLPAEDFIARMRSLKDRYWHDHPFHLRLHAGELEPRELRLWAANRWYYQRRIPQKDAAILANCPDLDVRRRWRERIVWHDGTHQGEGGAENWLRLAEAVGLTREEVLDERHVLPGTRFAVDAYVTFARARPWVEAVASGLTEMFSGALMARRLADMRSHYPWIAEEGFAYFTSRLEVVSDEGKSTLDIVVRNCPTLERQEAAIAALEFKCDVLRSILDTVDYYARKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N1</accession>
    <name>A0A7W7T8N1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="11818" checksum="156965437BA22E48" modified="2021-06-02" version="1">MIVTAFVDPSRTGEVAWRCLARRGMVHSECEAVDLVSLPPGSTFAPPGRDGVESAWFVVRGSGSADGLPVRTGDVVLAATPTRLAAGSAGLDVLWVAVLPAAVSALLPRRSPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8R5</accession>
    <name>A0A7W7T8R5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="11288" checksum="AE203D970C0CD450" modified="2021-06-02" version="1">MTSPADHIGRTTSQLRQLIARGFRFLHPRDARGELAAVVGVRAHHAVIDVVRLHTEDDVVATRMPADEANVLEPSRFSWRRRGPATSVLEELLDLPDDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T7</accession>
    <name>A0A7W7T8T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005815</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="154"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="367"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="401"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="620" mass="65924" checksum="C269DF99C87F50E5" modified="2021-06-02" version="1">MATPRWATRGRQAATVGLGKALRSLPSGIRLVIGLAWQASPRLTAAAGAVHLLSGCVTAFGLLATADVFAALLRDGPTPDRVKASLPALAVVIASYAVRALLDAAVAAVEGSLRPLVTTKANDEVTAVLVRANLLAFEDADFRELARQGGRHGVRSLDSSLRTSATLISAGISMIAAIVTAGLLDPWLVPALMLAAVANAWAAARVSKLRYQHFLDSVTRNMRKSVVEGVATERTFALERHAFVLQETLLDEYRRISVSLVRDQVRMAHRTNLVQLTGRALAGIGTGAAYGVLGLLLASGGMELALAGTAVLAMRTGFSALSRTTSAVNSLYEDSFYLDFYRRLLAEGAEQAQSTSGVTAPADPERITLTDVSFTYPGKDEPALRDVNLTVERGEVIALVGENGSGKTTLGKVLTGLFPASSGMVRWDDVDLADADPRTVHRSIAVIAQDPAQWPMTARNNVAVGRLDRDDPDAWQSAVTRSGADEVIATLPAGADTVLSRQFNDGQDLSGGQWQRMGIARGMYRDAAVLVADEPTAALDAKAEARVFTGLRAAAARRTTILVTHRLANIRNADRIVVLDRGVVVEQGTHDELMALNGQYFELFELQAAAYRGDLLADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z0</accession>
    <name>A0A7W7T9Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative copper resistance protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="231"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="35323" checksum="E34039B88A7275CD" modified="2021-06-02" version="1">MTVDRTTAPTSRTWVVGGLLAGGLVGVLLGLDLSSTPADVGDVEAGVVVRFAHPLVRTLLDLAATAAVGLSLLPKLLGFSRPAATEPVLRVARPAAVIASTVWALTALVSIVIRAYETRPEMAVTLSSVVDYVQRVGAGQGLLFSAVCALASVWIGIMAVRRGESVPAELRILVTMFGLLPLPVTGHASNWKYHDYSMISMELHVLGAAAWTGGLAALVVLVAHRKSLLAEALPKFSKLATVALVLVSVTGLFNGVLELALNPVVALPGSLVTTSYGLVLIGKTVCAGLLALLGAHIRWRLMPHIARHRTTAVVGWAAVEVAVMGVAFGLAVVLSRAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA01</accession>
    <name>A0A7W7TA01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydrofolate synthase/folylpolyglutamate synthase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
            <ecNumber evidence="7">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EC" id="6.3.2.17" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="141"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="454" mass="47963" checksum="45822A6FC540AD71" modified="2021-06-02" version="1">MSAVDPAALEDLRQVEAELDTRWPETKLDPSLDRVRALTEILGDPQRSYPVVHLTGTNGKTSTSRMIDALFTRIGLRTGRYTSPHLQLATERINVDNEPISPDRYVEVYRDVEPYVSIVDARGDVPMSKFEVLTGMAYAAFADAPVDVAVVEVGLGGTWDATNVADGRIAVITPIGLDHVDYLGPTLEGIAEEKAGIIKPGAVAVLAEQDPVVERVLLRRAAEVDATVARQGAEFGVLGRDVAIGGQVLRLQGLGGIYEDVFLPLHGAHQAANAALALAAVEAFFGAGADRRLDVEAVREAFATVASPGRLERVRSAPTVLVDAAHNPHGAAALAKALDEEFGFRKLVAVVGVMADKDAEGILVALEPVVNEVVLTANSSRRSMDPDALASLAVPIFGEDRMVVVPHLVDAVEEAVRLAEEDDDTGVVSGGGVIVTGSVVTAGEARALFGKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA08</accession>
    <name>A0A7W7TA08_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (AIM24 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="22361" checksum="37C2DA70243AD0F6" modified="2021-06-02" version="1">MQVRTRHTPTFGVARLVLAPGEPVLVERSSVVATSYGVRHEPRAKVPGLHASTCTAGPEGGWVDVAPALPGDLHVMELDGTTGWCVAKDGWLASSATVTADQAAPPLRALHGGDSGFLHYLFGTGQVVLACYGVLDLVTLEPGELVTVDSGHAVAFADTVQCRLRAVSPGASQSVRNGEGLVLDFAGPGLVLTRTRSTRGLVSWLRDNGFSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA17</accession>
    <name>A0A7W7TA17_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Poly(A) polymerase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="250"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="465" mass="51249" checksum="AAD01ED7F1071A0A" modified="2021-06-02" version="1">MELSNTFPVATDLAGRFAAAGHRLYLVGGSVRDAFLGRLSGDLDFTTDARPPQVLAVLKGWADAIWDVGIAFGTVGASKDGQTVEITTFRSDAYDRVSRNPEVTFGDTVEGDLVRRDFTVNAMAYDLLERRLIDPTGGRAALAAGVLDTPATPAESFGDDPLRMLRAARFAAQLGFTVAPRVSEAMKAMAGELGRITAERVQVELSKLLLGAHPRAGVELAVSTGLADVVLPELPAMRLEIDEHHQHKDVYSHSLTVLEQAIDLETDGPDLTLRLAALLHDIGKPGTRRFESGGGVSFHHHEVVGAKLVRKRLRALKYAKEIVADVAQLVYLHLRFHGYGGGEWTDSAVRRYATDAEHLLTRLHKLVRADCTTRNKRKANALQRTYDDLERRIERLAAEEDLARVRPDLDGNEIMRLLDLPPGPQVGQAWKFLKELRLDRGPLEHDEAVSELFAWAEREGIRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCX7</accession>
    <name>A0A7W7TCX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="56"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="310"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="385" mass="39555" checksum="666ECBF16ECDE9C5" modified="2021-06-02" version="1">MSTWGGPVDVTLTGGRVVTPEGVLARGWVAVRDGLIVAVGEGTPPDGPTTDIGNGWVVPGFVDIHCHGGGGEAFTSADPERVRKAASAHRRHGTTTMLASLVSRPIPELANQVSALAELVEDGVVAGIHLEGPFLSAARCGAHDPAILCPPDKASVETVLTAGRGTVRMVTVAPELEHGVEAIRRLVDNDVLAAIGHTDATEAQIRPAIEAGATVATHLFNGMRPLHHREPGPIGALLDDERVTVELICDLVHLHPTAVRLAARHAGSGRTVLVTDAIAAAGVGDGVYDVGGLEVRVVDGVPTLAGGGSLAGSTLTMDSAFRNAVTSCGLSVEDAVHATATRPAELLGLADATGRLAAGLAADIVVLDEEFRPREVLSRGAWVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT19</accession>
    <name>A0A7W7WT19_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator RegX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="25083" checksum="1606AA07E76B2461" modified="2021-06-02" version="1">MTRVLIVEDEESFADPLAFLLRKEGFTAALAGTGQEALEEFDRNGADIVLLDLMLPGMSGTDVCKQLRQRSAVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRGGESEELLPQVLEAGPVRMDVERHVVTVDGGEVSLPLKEFDLLEYLLRNVGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEPDPSAPRHLVTVRGLGYKFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTF4</accession>
    <name>A0A7W7WTF4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">F4559_000499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17016" checksum="F170D738709565F6" modified="2021-06-02" version="1">MTQVGVIMGSDSDWPVMKAAAEALAEFDVACEVGVYSAHRTPQRMLDYATSAADRGLKVIIAGAGGAAHLPGMVASATVLPVIGVPVPLKYLDGLDSLLSIVQMPAGVPVATVSVGGARNAGLLAVRMLAASDEGLRKRMAEFQASLEELVLAKDEALRLRTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTF8</accession>
    <name>A0A7W7WTF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17021" checksum="FE61C8613A29863C" modified="2021-06-02" version="1">MSRLEASRFAADRLTEVLARTVGRAEHPSGLARVTATANGELRDLQLHPALLAQGPDAVGRTVVETARLATDAAVQTSFNELAKALGDGVAIAVEAFVGAPPFRVEAERSVAEPESTSTPFAPAPTPPVTGPPARAQRPRPPAEEDEDAYFADPFRGQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU2</accession>
    <name>A0A7W7WTU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8164" checksum="4255EE127FD422F0" modified="2021-06-02" version="1">MTGYTIRLRTIPFAKAMLLAGFRSDYVLSKAMGVNRTTVTRVRTGELNPGAAFVAGALTALSPLDFDDLFEIVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX3</accession>
    <name>A0A7W7WTX3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="344" mass="35816" checksum="3495C92176C81F50" modified="2021-06-02" version="1">MPNLVVLTEQLLAPVPGGTGRYTRELARALAATAPAGWTVTGVVGRHADVEAARIPGVLGPRVLPLPRRALVAAWERGVPLWPGGDAVHAPTPLAPPRGRVVVTVHDTVPWTHPETLTPRGAAWHRKVIERAAARASALVVPTRAVADELRSFVSLRAPVHVVGNGVTDLGEAVPVDVPERYVLAVGTIEPRKGLVDLSRACAEIGVPLVVVGPQGWGGVDLRAPHVRLLGRLSDARLAYVLRRASVLAAPSLAEGFGLPLVEAMAAGVPVVHSDAPALVEVAGGAGVAFPRGSVPGLVAALRSVLFDEALSGLLVADGRQRAEAFTWENAARAVWAIHQAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD7</accession>
    <name>A0A7W7WUD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13348" checksum="CAE6B54377D70D18" modified="2021-06-02" version="1">MGERTGLAIVGAIMLGCAAFGPFPHPVPLLFVIAAAGAANAAFPLMRTFGAMLLGGVATASIGLAAVPFATCSAERFQDVFPCTGDAPTWHLTGTVLVAGLAGAALVLARVAGADDLRRRVELLERRTRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF4</accession>
    <name>A0A7W7WUF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13566" checksum="5452CB802F77E3E2" modified="2021-06-02" version="1">MVQDDETATTVPWRPTGPEELALVRESGWRAWPPRLPDQPICYPVLDEDYAIKIARDWNVPHSGVGYVTRFRVESAFLARYPVRRAGGRTILELWVPAGEPDEFNAHLVGPIEVVPEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP4</accession>
    <name>A0A7W7WUP4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FmdB family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="6561" checksum="1DB5FED6333AF5BA" modified="2021-06-02" version="1">MPTYEFRCKTCGSTFDVNRPLAESSAPASCPEGHDDTVKLLSMAGLAGKTTGGGQGGGGCCGGGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV2</accession>
    <name>A0A7W7WUV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-6-phosphate dehydrogenase assembly protein OpcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="35977" checksum="AE997DE420D21DE6" modified="2021-06-02" version="1">MIIDLPSTTTSQVNSKLVQLREEGGAVTLGRVLTLVIVTDDGAKTEDAVDAANDASREHPCRVIVVARGARKAAPRLDAQIRVGGDAGASEVIVLRLYGELANEGASCVVPLLLPDIPVVAWWPNEAPAVPAQDPIGQLAQRRITDAAAEKNPIKALEQRKASYTPGDTDLAWTRLTLWRAMLASAFDLPPYDKVTDAEVGGEGDSPSTDLLAAWLAAYLKVPVKRQRAAGGEGIVSVKLERRSGTVSLTRPDARVGTLVQPGQPERRVALQRRSTRDCLAEELRRLDPDEVYETALRALGKVVRGRAPVKPAARKPKPVEEPVVAKRGAKAKAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUZ7</accession>
    <name>A0A7W7WUZ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="6">OTCase</shortName>
            <ecNumber evidence="3 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="8">
        <location>
            <begin position="148"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="6">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="6">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="34099" checksum="85CE91D22056AF34" modified="2021-06-02" version="1">MVRHFLRDDDLTTDEQVEILDLADRFKLDRLGAKPLAGPRSVAVIFEKNSTRTRLSFEVGIAQLGGNPVIVDGRSMQLGREETIEDTSRILSGYVDAVVWRTFAQKRIEAMASVSRIPVINALTDEFHPCQVLADLQTIRRVHGRLAGLTITYLGDGANNMSNSLLLGGVTAGCHVRVAAPAQFAPAPWVLDDARRRGAETGGTVEVVVDPREAVDGSDVLVTDTWTSMGQENDGRDRVGPFRPYQVNADLVAATGVRTTVLHCLPAHRGWEITDDVLDGPDSAVWDEAENRLHAQKALLVWLMERSGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV54</accession>
    <name>A0A7W7WV54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="43042" checksum="65D35995151DF4EB" modified="2021-06-02" version="1">MSDLAWDSETNRVAALHALRLLDTPREERFDRITRMAQDVVHAPIALVSLVDLDRQWFKSCVGLDATETSRGTSVCSFAIRHDEVFEVEDLTADERFADFPVVREAGLRFYAGQPVAAPSGHKIGTLCVLDRVPRRLTPVEHTRLKALATWVELECAVVQATLGAQDAERAKRDFVAMVSHELRTPLTSVHGSLELLASGRFGVLEERASQLLDIAVNNTDRLVRLSDDVLDLSKVRCDQLRLHPTSVDLDRVVVTAVHAVEGTAERDGVPLTTEVEPVTVRGDADRLVQAVTNLLSNAVKASPRGHAVTVGCTSDGSLARIKVVDEGSGIPADQVQRIFEPFVQLGRGGSGLGLTITRGIVDAHGGAIAVESVPGKGSTFTMTLPLAGPHVDRPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC1</accession>
    <name>A0A7W7WVC1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="438" mass="47940" checksum="2E856E11507595A8" modified="2021-06-02" version="1">MNDDQIPPAPESAGEELARQIRQRRDQAGLSQPKLARLIGYTRQYVSRAERPNHNLPSIDLVRALDTALDARGALVALREKAKEERINLRMQTVEAVADSDTADTRPDSPFHGGTRSEQDRESMRARSSHDDVRPHHDRSMAVDSAIFHAAASVERLHRDYQAAQYAEVEEHLPEVADTVEALLADSGGDRRRLLRLRCQAAVVHAKVATKRGDGITAFEAAERARHAAEEAGDPFGRASAAYQLSCALIRLDDAERAESHALDTADSLRGHDPHTLTWQGMTTLLAAVLAARDGDIRGARQRLDRAGRLAEALRGEVNIGHTAFGPTNVSIHRVGVAVAVGDPDLVLAEAAEVDVTVLPPGLHGRRGRFHLDNAWAHTRRREDALAVIHLLEAERFAPQLVATDCQGKAVLRELLSRERVTRTPGLRPLGVRTGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ5</accession>
    <name>A0A7W7WVJ5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_002326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="11">
        <location>
            <begin position="152"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="376" mass="39030" checksum="BC5B719927BF9CD4" modified="2021-06-02" version="1">MTATGSWRRQAGRDGGLPLFRAAGIPVVLAPSWWLGSAAVVVLYAPLVDRIAPGTGGTVGFVVAATFALFLGLSVLAHELGHSLVALRLGLPVRRLRLFLLGGVSEVMRTPAKPAHEMLIAAAGPAVSILLAGAFTIGAAAIPHPDAVWLLIAQTAFANAAVAVFNLLPGLPLDGGRILRAGVWAATGRRAAGTRAAVLGGGVVAALLVGWAVLGLADGAEDRWLRFAVCVLTAWFVVAGARGEAKAERRRTWPPGLSLRDLVRPVLQLPAESPVSDALAAAAGRGVVLVRADGIAAGLLDQGLAERLVTTSPHAPAEQAAVPIRPETVLLEDEPGEEVVDRVDGTAAWEYLVVDLDGRPAGVLRREDLRAALDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL9</accession>
    <name>A0A7W7WVL9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="95"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="30542" checksum="0C4D0A12B11D3302" modified="2021-06-02" version="1">MKVALATCASLPAGDGDDADVPGALADIGVESAWLRWGPETDTDTDTDTDADLVVLRSTWDYPERAAEFLSWCESVPVLANPAGVVKWNLDKAYLVDLIEAGVPVVPTAVATPGFDAWPEGEFVVKPTVGAGSRGALRVAAGDHEAAAAHLAGLGGPALVQPYQADVDHVGETALVFFGGRYSHAFTKGAMLVPDTVTDPTGLYLVERLDRAEPDAARRRTAEDVLDAATGLLGVRRADLLYARVDLIPGVDGRPLLLELELVEPSLGFGLADPGAPARFASAVRAALVDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP0</accession>
    <name>A0A7W7WVP0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29840" checksum="E105ED34F3FFC8EA" modified="2021-06-02" version="1">MTADVLVELPDADVHVEVLGVDGPPVVLVHGFLTSSYTWRHVAPLLASGFRVYLVDLPACGRSPVPRSREWDARRCVALLGGVLDHLGVERPVLAGSQMGGSLVAWFTALHPERVGRLVVMAAGALGEARSNLLLYRLLANPLVGPVLARAFPRTAFGDKWRDAHGPGFTPEVDAVDRYHRQLRERGSAIAAFGLGFRRDYGAEFDRLAPLLAGCAVPTLLLFGQDDPLVPPSTGRRFRELLADAELVLLPGCGDFPQEERAEEVAVAVVRFLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW16</accession>
    <name>A0A7W7WW16_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="28689" checksum="C9709CC59D602F2C" modified="2021-06-02" version="1">MRSQDYGRDVLAGGKKRSVPEVAAEPGVVVEDPASGFCGAVVRFESGNVVLEDRHGRERLFPLRPAGFLVDGRPVTLVRPAVAAATPTRSASGSVRVEGLKARTARDSRIWVEGLHDAELVERVWGHDLRVEGVVVEPLDGVDVLADRIAEFGTGPGRRLGVLVDHLVPGSKESRLVAAVRDEHVLVTGHPFVDVWQAVKPAAVGIAAWPVVPRGVPWKDGVCAALGWGEPYEGWRRVLAGVRGFRDLETSLLGAVERLIDFVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW80</accession>
    <name>A0A7W7WW80_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoin utilization deacetylase AcuC-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="36"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39732" checksum="9E714FE6E2384420" modified="2021-06-02" version="1">MATGYVYHELYGWHDTGTHASLLPADSRRGLEPYRHYENPDAKRRVHELVVVSGLVDKLTRLQPRPATDEELLLVHTPEHLRRLAQANDTGGDGGDGGTPFGRGSFDIARLAVGGVIRSVEAVLDRRVRNAYALVRPPGHHAVAASGMGFCLLANIAVAVQVARRRRRVGRVAVVDIDVHHGNGTQAAFWEDPDVLTISLHQDRVFPPNSGFVTERGAGKGFGYNLNLPLPPGTGVGGYLEAVRRVVVPALRRHKPDLVMVAAGFDANAQDPLARMMLTPRGYREIARQVVKAADELCDGRVVCAHEGGYAAAYVPFCALALIEVLAAVEKPYPDPFGFDNMGQQELQPHQLTAIKATEALLGDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX79</accession>
    <name>A0A7W7WX79_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6A/cobalt-precorrin-6A reductase</fullName>
            <ecNumber evidence="4">1.3.1.106</ecNumber>
            <ecNumber evidence="4">1.3.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.106" evidence="4"/>
    <dbReference type="EC" id="1.3.1.54" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="237" mass="24256" checksum="287DD9E346AC810C" modified="2021-06-02" version="1">MRTLLVLGGTGEGRALAAALTGLRVVSSLAGRVAAPRLPVGEVRIGGFGGVPGLLAYLRREAVDAVVDATHPFAGRITANAFAATREAGVPFLLLRRPGWTPVPGDDWHWVDSVREAAAAVAGRRAFITTGRQELAAFASGVARTVDPPDPPVPGVQVLLDRGPYTVDGELELLRAHGIEVVVTKDSGGAMTAAKLAAARHLGLPVVLVRRPPVPDAPSVGTVGEAVAWLTGGSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE4</accession>
    <name>A0A7W7WXE4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24651" checksum="72AC55B4BCC27985" modified="2021-06-02" version="1">MVELLHQALYRAHPTHVDPDLSPYLYGVEGPASPTPAPEPGMPTTLVLTHVRRLLNPQATPAARHAQRLGLVEDAVHDGLLTRPVLPIIGWPADHAENVRQVTDAATTKAGTDGFVRFLAEGIIAACHHEIALVDALPGLYGRLAGRLPHNPGRFQRRVLADLVAHPVTSGPDLVHRHNTTSRTAVNTITAFRDAGILLPHGTTQYGRTVYCPAALELVHHHDTTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH6</accession>
    <name>A0A7W7WXH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="48933" checksum="6927D2FFCBA647E4" modified="2021-06-02" version="1">MTDNELVAPVKDDGKVLAGAGIFDTAEDIGRNVFATRSDDDSGRAKEIDEIAAAIDGIAMSLGVVGVIADPLGSLASSAVGWIIENVSWIRKPFDDLAGDPPAVEAVANTWKNISERLAQVAGQYQENRTEVVDWRGTSAASYGEHASKLGGQLTNASESAKDASSAIKLAGAAVAATRALIRDVLAELAGTLITWGIPAPASAVPTAGASIAAFVTRAVTKAIEIGGRIAQFLKKLFTIMDTLSALAKRMGGSMRGRADELADMARVSPNTPVGNQRAADLMHASTTRASRADSLDGAGDTLAGGAQRGRDAMDNVTNKADALADNWNRRASDWADRVKQNGPNRRQKVQDVYDKLGSPSMNTRSADMPDSRWAWLTKADNATGNGILSGQNWVRAARTFDLGHLMPAWGDVISPIREGLKELNKAFLAEDYEKAKEHHRNRGDQVFLPYRNREEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ4</accession>
    <name>A0A7W7WXJ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="38387" checksum="5F9891F43F10053F" modified="2021-06-02" version="1">MDQPIGIAVVGAGYWGPNLVRNAQATPGLKLRYLCDLDTERARRVLGDYSTVRVSGSLDDVLADPAVDAVAIATPAATHLPVALAALRAGKHVLVEKPLAASYEDGLELVREAESRGLTLMLDHTFVYTPTVQHLRHLVRSGEIGSVQYLDSVRINLGLVQPDVDVLWDLAPHDLSIFDAILPDDVRVTRVSAHGSDPIGAGRACVGHLTLELSDGVLAHVHVNWLSPTKIRTMIVGGSRRTVVWDDLNMVQRLSVHDRGADRVEGDEDRRQAIISYRRGDTVAPALPEKEALRGVMQEFAASIAEKRAPLTDGWSGLRVLAILEAASASLAGGGEFVTVRDVPGRGATGLAQEEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ9</accession>
    <name>A0A7W7WXJ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase B (Cyclophilin B)</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031177522" evidence="1">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="80"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="24232" checksum="8239D7BDE03E2C1B" modified="2021-06-02" version="1">MRRRLIATVSTALLLGACSYSVTGAPQGSPSSGGPSIEGPTVDCEYVRDRTGNTVKAVDPPSAKAAAQGEYVFTAQTNRGVMEFRLDAKSAPCAVHSFRYLVESRYYIGSTCHKLSTEGLFYLQCGDAGTTGKGDPGYRYSDPGATTSGYRRGVIAMASPDRTDSHGSQFFVIYQDAAGWAPDFPIIGKVSIGLEKVDDVAKGGIVAGTAEDAGVGRPSLALTITGLAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL4</accession>
    <name>A0A7W7WXL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12727" checksum="DEE6482555566EED" modified="2021-06-02" version="1">MLRATFSLGPAPTVDVIKWPNSDLRALCLEVRPDEVIVIGPTDRPGGAVEFAAYLREMASHCVRLAAQVDPQSGRHGQSPDTTMRALNQQASSWFRPHGDESRYGNLGETGAGRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY05</accession>
    <name>A0A7W7WY05_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-strand DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="16077" checksum="30CE92AC1E0ED83D" modified="2021-06-02" version="1">MVTHTTADTGLSRASFRMYSRERRYNRETEVWEDGRQLFLNVTCWRKLADNVHMSLNKGDPVVVTGVLRIADRDLDGIARQFVDIDAHSVGPDLTWCTAEVRAQRHRSGADLPRTEADVPRSDPASAAAVDRASPPEADAEVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY84</accession>
    <name>A0A7W7WY84_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="36738" checksum="DCB1257A48DF65B9" modified="2021-06-02" version="1">MTSTDPADRALLRHHGDVDAAPGLVDFAVNVRLPRPPAWLRDRLAAALDDLGRYPTSTAAAREAVAARHGRRPDEVLVLNGAAEGFALLPVLRPRLAAVVHPSFTEPEVALRDADVPVHRVHLSAADGYRLRPDAVPDEADLVVLGNPTNPTSVLHPREVVAALARPGRVLVVDEAFADTVPGEPESLAGADLPGLLVLRSLTKTWGLAGLRAGYALGATDLLARLDLHRPQWPVGALVLEAVEACCAPAAVAEAVRWAAESVAHTRAAYEALGEFAVVEPCAPFVLLRVPHGERVRISLRDKGIAVRRGDTFPGLTADHLRVAVRGPAENALFVDALRVVLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY87</accession>
    <name>A0A7W7WY87_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="305"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="441" mass="48193" checksum="99302FA217F2A6A3" modified="2021-06-02" version="1">MDSSPEQVRFTEEEALANLRAVLELCAAQKVKCSDKTRRPSAATVRTVGAHLVGGDFYDDEPIAAFAWPLLLQAGGLATLDGTCLRLTPKGRAALGKPSAEVIRDLWRRWLTHAVIDEFSRVEQIKGQQARNVLTAAKTRRQAVAAALAGCPPDKWVDVDFLFTAMRRGNMSPTIARNDRAVWKLYLVDPEYGSLGYDGHHDWELLEGRYTLAVLFEYAGTLGLIDLDYVDPRGARDDYVDNWGGDDLDALSRYDGLVAIRLTALGAYALGLTDAYQPPEPTTAGARPLKVLPNLDVVAMGDIGAADRLVLSAYAEQTADRVWTVSAAGLLTALDNGRDLGEFVEFLVARTGHELPDAVRTLVADVERRGSRLTDFGHVRVIECLDPALATLITRDRALRGLCRPIGDRHLAVRPDQEPKFRKALLKLGYVLPAGVRGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR6</accession>
    <name>A0A7W7WYR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="84"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="35654" checksum="1EDBCC9A2D07988B" modified="2021-06-02" version="1">MTATLDRVDVPGAAPSRRPRARGRLVALAFMAPALIGFLAFFGYPLIATIGFSFTKYDLINPPKWIGFANYEYMFSDKLFRTSVYNTLWFVVVLTTARLVFTLGVASVIARLKSGVGLIRTLCYLPSLAPPVAATLVFFMVMRPNGGPVDEFLDWFGIQSPLWFADPAWAKGGITAVMLWVSGDLMIIILAAILDVPQEQYEAAELDGAGPLRRWWHITLPSISPVLLFGVVNSIILALQLFTQAVVAGSAASGSAEATGNTKYLGYPENSTLTFPAWLYTQGFRYFDMGYAAAMATVLFIVSFAATAVLVHRMRKNSHQEEGGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW1</accession>
    <name>A0A7W7WYW1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="5">
        <location>
            <begin position="519"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="565" mass="61628" checksum="D7AF3B74F6098992" modified="2021-06-02" version="1">MVAGTIVWNAGSEGVGSAAAEPLKSIVPVPVSVQAVPDAAYTITMSTKIYVAPGARAVGDYLAGVLRPSTGFPLDVVENPTPPDGIILQNASAPGNDQGYELITSTTSVTIRASTNAGFMSGAQTLRQLLPAKVEYRWQTPGPWTVPGAKISDYPRFPYRGAMLDVARHFHPVATVKRYLDQLALYKINFFHLHLSDDQGWRIVVDSWPRLTTHGGSTQVGGGPGGFFTKDEYKDIVAYAAARQITVIPEIDLPGHTNAALSSYAELNCNGTAPPLRTDIEVGYSSLCISKDVTYKFVEDVIRELAEITPGPYLHIGGDEANATSDRDYQTFMDKVLPLVGKYGKKIFGWHEFVKTTKDTTVVPQYWGTTTSNAVVQAAAARGNKILMSPANKAYLDMKYNSSTPLGLSWAGMIEVQDAYNWNPGTHVSGVQESSVLGVEAPLWTETIVKPEHIDYMVFPRLPAIAELGWSPWSTHDWNAFKARLGAQGARWNFMGIQFYRSTQVPWDGGPTTTSPRPPTAWAAYTSYAAEDKVTYNGTTYKCLQQHMSLPGWEPPNARALWAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZR7</accession>
    <name>A0A7W7WZR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized membrane protein YjfL (UPF0719 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0719 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007140">
        <property type="entry name" value="DUF350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03994">
        <property type="entry name" value="DUF350"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="15382" checksum="9919C9760C42F646" modified="2021-06-02" version="1">MITELALEPGFGSTIGQGLGAIALYAILGTLLMVFGFYAIDWTTPGKLSYLVRTGAPNAVVVTAAGLVSMALIVVVVIYNSGGRLADGLLTGLIFGLAGIVVQVLAVRLLEWVTRLDIGSLIESDKFAPASVVVAAAHLALGLVVAVAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXL5</accession>
    <name>A0A7W7SXL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="38222" checksum="FFFA98DB5E5E27A0" modified="2021-06-02" version="1">MAPKVVLVTGCSRFLGGHLAARLAADPAVDRVLAVDTEQPSRDLRRRMGRAEFVRADIRNPLIAKVVATAQVDTVVHASVTANPAGPTGRTAMKEMNVLGTMQLLAACQQSPHVRKLVVKSTTAVYGASSRDPAVFTEEMGPKDLPSRGYAKDAVEVEGFVRSFSRRRPDVDVTVLRFANFIGPRIDTVLTRYFALPVVPTVLGYDARVQLLHAEDALAVLDRAVRHDLPGVFNVGGDGVLMLSQAIRRAGRVNLPVPSPAVPLTGRVFRGARLVDFSPDQMRFLNWGRVVDTTPLKERFGFTPRWTTLQAFDDYVSGRGLRPVVDRDLVASVEHRALDLVSWLRGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXQ7</accession>
    <name>A0A7W7SXQ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">F4559_000267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005166804.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="8461" checksum="8E5BD89FD087444D" modified="2021-06-02" version="1">MGKKDGAIEVEGRVVEPLPNAMFRVELENGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLSRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXS1</accession>
    <name>A0A7W7SXS1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">F4559_000245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10899" checksum="7717A535226FAEAA" modified="2021-06-02" version="1">MIPDHRDILLAPVISEKSYGLLEENKYTFVVAPGSNKTQIKIAVEKVFGVKVVSVNTINRQGKRKRTKTGYGKRKDTKRAIVTLSAESKPIEIFGGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ88</accession>
    <name>A0A7W7SZ88_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="8">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="6">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="605" mass="66264" checksum="2B8E48A875A9B8BD" modified="2021-06-02" version="1">MAGITGWFDHDRDISHDLAVARHMTAALATRGPDDERLWAAPHVVLGHRRLAIADPVAQPAVVRAGGRSVTVTFDGELYNRASLAERLGRDGSDAELVGAAYLAWGERCVREFDGPFAFGLWDGTALVVARDHIGLRPLYYCETPTGALFASEPKALLSHPLVEVAVDLDGLREVLSFAGTPGHAGYRGMRKVEGGHLIRFDRTGAHHTRFWGLEDGEHTDDFDTTVDRIRELLADSVARRVGTDDGFSIMLSGGLDSSLVTAMAAKVLRDKGVDRIRTMAVDFVEHARNARKSGTDDSTFAAELARHIGTDHQDILLDRELLLGALPRAAAVRAYPDLPCPVGEMTTALYVFFKAVADNTSVTMMGEWADTLFGAFLRMEDPEVVARRTLPWVASGQLHVRSTGLGSGLFDPTLLKQLDLPGYCADRYRDEVAVMPSGGIESDHDRRMREISYLYLRGWMEMGLAQDDGLTSAHGLRFRAPFADPALMQYVYTIPWSTKTFDGRSKGLLRKVAEGFVPKSIVDRPKNPFPSTPDLAHASALRAEALAVLDDPNSPVLPLIDVAATREAVADVEALATGWQGRGDVEMVLQVDTWLADYRPRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ97</accession>
    <name>A0A7W7SZ97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21658" checksum="F25806C96677A541" modified="2021-06-02" version="1">MPRPKTHDDALRARLLDRAGELLSSEGPNALSLRRLAADVNTSTTAVYSLFGGKPALLDALYEEAFRRFGERVAAVPLSDDPVENIVRIGLAYRRSALADPQFYLVMFSKVVPNFEPSEETGSAALRTFQPVLDNVRRAIELEIFVAAPEEHIGIAVWGMVHGLVSLELNGNLPAELTIGEMYERAVRANVNGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT6</accession>
    <name>A0A7W7SZT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="44679" checksum="ED1E8F7E8B104294" modified="2021-06-02" version="1">MERTTVAIAGGGPAGMVLGLLLARAGVDVTVLEKHADFLRDFRGDTVHASTLTLLDELGLGPSFAEVPHQLVERMAILLDSGPQTVADLTRLPGPHKHIAFVPQWDFLDLMADAARREPSFTLRMSTEVTGLARTGSKMTGVHYRGPDGAGTLNADLVVAADGRGSLVRAEAGLPVHRFGVPMDVWWFRLPRGTEDVGGGLGRFGPDTAVVLIPRGDYFQTAFLIRKGTDARLRTEGIEAFRARVAKLVPWLAERLETVESLDDVKLLDVKLDRLRRWHADGVLCIGDAAHAMSPIGGVGINLAVQDAVATAAILAAPLRRGTVTPSVLAKVRRRRLFPTVVTQTFQRLVQGRFLSPPGDKTPESTRPPLPLRLLQRFPVLQGVPAYLVAIGLRPEHAPAFARRAPERIPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZV7</accession>
    <name>A0A7W7SZV7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016794">
        <property type="entry name" value="UCP21603_acetyltransf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021603">
        <property type="entry name" value="UCP21603_acetyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30050" checksum="443A26076004ED4A" modified="2021-06-02" version="1">MLRLAGARVLDERDLPGVLAALAADPVAACMVASRVEVAGLDPWRLGGEMWAYDPRSLRGGRADALCFAGPNMIPLSGDGAALRGFADRARRRGRMCSSLVGPAAQVLGLWEELAPDWGPAREVRADQPLMALGGATTITPDPLVRPVRPQELDRYLPAAVAMFVEEVGVDPCADDGGVSYRARVAELIAGGRAFARFEGGEVVFKAEIGAMSAKVGQIQGVWVRPDRRGRGIGAAGTAAVAERLVRGLGRTASLYVNSYNDAARAAYARIGFTQVGRYATVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T036</accession>
    <name>A0A7W7T036_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23217" checksum="254F261927A02A31" modified="2021-06-02" version="1">MDRFWNLLTPEEQTVFRAAGVEHDYAPDAVICHEGDTTGHVLVVLRGLLRVTKARLVGAEKVLAVRGAGDLLGERAAVDGLPRSATVRALGPVRALVVSAASFARLCQRRPRIAWVVLTVVIGRQRDVDRQRVQFSGSATQRVAAVLVDMVLHRGIADQGAVSLSQEEIASIAGISRESLVRVLRSLREKGIINTGRKKIDVVSPERLYDLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H3</accession>
    <name>A0A7W7T0H3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="23293" checksum="B4B4854BC070F5DF" modified="2021-06-02" version="1">MWRSEVGSLDAMMGAPPRPSPPARQGWLVKAAGLLAIAVVSGLVWVVVFAPDDEPEGPLPVPGQSASAKNAKFQPSPQVPEPLKDSDCAPHAYGKTKEFLTATRCRQLTRQLFTSTTTDGRTVYTSVSVVRMASADDAAKLRDLTTKDGTGNVNDLVKDGAVTVPGLRTLASGGYASEQQDSDVVIVESDSVDRNPDTSAHNAEMKRVSTEALGLAASLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J1</accession>
    <name>A0A7W7T0J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="428"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="634" mass="67802" checksum="2A586A940681C66A" modified="2021-06-02" version="1">MRPDDLPSLTLPGSVSVRGDLVLVDVSTPDVGANAYRGALHRVALDGSGAHRYTWGERDLAPRLSPDGGRVAFLRVPGEGKAPQLYVMPAAGGDARRLTDLVLGAGVPVWSPDSRTLAFVARVPEPGRYGSELDGVTPTPDAEAPRHITRLDYRFDDIGFTGDRPARLFTVDALDPDARPVELTDGTVDVADPAWSADGTRLLFVADRDLGVEETLESDVYSVPAAGGEAELLVRTQGDAAFPVGLPDGGVLFYGIEAHGGTGIARNLGLWRWTRAGGAVRITDTETVDCEKLSGPPVVTDDGVLVAVRDRGAVQLRRVPLDGVGCPLDHLELLAGDRAHVKSFAADGDLVVAVVSTPDNTGEVVRLGTGPLTALGGAVKAHEVVELSGSASDGYPVHGWLVLPDGEGPHPVVLAVHGGPFMFHGWGFWDEAQVYAGAGYAVVLPNPRGSAGYGQEHGRAVIGRFGTVDVDDVLSVLDVALERDDLDADRVGVMGGSYGGFMTSWLAAHHGERFRAAWSERAVNAWDSFGGSSDIGWYFADAYCGPNLETQRAMSPLTYAEKISIPFMVAHSEHDWRCPLEQAQRMFVALRRNGVEAELLLFPGEGHELTRSGKPRHRAQRFAHVLSWWGRHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N4</accession>
    <name>A0A7W7T0N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11139" checksum="836E74F202EFD00E" modified="2021-06-02" version="1">MAATLAESYTLTRVASFVERVAVAVANAAVAVATETPENTERSRLRRALAARIAENRDGLDYAARFALLVARNPAIVLGSSDNDIQFTVNSVWDAVAGAEPPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W2</accession>
    <name>A0A7W7T0W2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-amino-4-hydroxybenzoic acid synthase</fullName>
            <ecNumber evidence="3">4.1.99.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.20" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQ_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="entry name" value="PTHR33563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="38040" checksum="8B788CA2ABE8182A" modified="2021-06-02" version="1">MKFAWIDLRPVPEAHREAVVDAAVHASLGGVVSDDPALLDTLPPTLTRVLVAPEPVDSPHLVAVVATDRDQLDRLPTDAAFVHVDDDRTLRLACAAAVKLGHTIVEFADPTKIPLEIVIAAADGASGRLVTVVADLEEAAIVLDVLEHGSDGVLLAPADATDVFRLARLLEATSPPLTLTTLTVAGIAHTGLGDRVCVDTCSHFDEDEGILVGSYSSGFILCCSETHPLPYMPTRPFRVNAGALHSYVLGPDNRTNYLSELRAGGTVLAVNAEGRTRRLTVGRAKLETRPILTITAHSPEGVEVSLTVQDDWHVRVLGPGGKVRNVTELTQGDELLGYVATEQRHVGIPIGEFCKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T104</accession>
    <name>A0A7W7T104_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system N-acetylglucosamine-specific IIB component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="4">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8152" checksum="6ADDDE6E09989272" modified="2021-06-02" version="1">MADDRAAKILAALGGADNIVEIEPCITRLRCELEDGSVVDEKALKGIGAHGVIRQGNVVQVIVGPEADTIASDIEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T120</accession>
    <name>A0A7W7T120_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="23386" checksum="7BC4E73906F59537" modified="2021-06-02" version="1">MSGLARLTPAGFEVAWEQLGLGALPYPLDLEPHGRTRAERERIVADVLADLERGGLARRGRVDADVEDALRLLAQPDSAFTVLGLVDVEAGELVRALAAERRGFTVLAVRRDDAVTLDVRRGGSPAATAVGVLPHRPPGPGRTVTVRASALATGGPAHRDDEVRAARAVLAGPIVGTGHVAALGGRSVTWIDTPHGRYAADGTDWITVAPADRAGMVARITRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T146</accession>
    <name>A0A7W7T146_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">F4559_002003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="27557" checksum="1FBF4592D9363C43" modified="2021-06-02" version="1">MASRQPLIAGNWKMNLNHLEAIALVQRIAFSLPEKYYAKVEVAVLPPFVDIRSIQTLVDGDKLLLKYGAQDVSPHDSGAYTGDVSGPMLAKLGCSYVTVGHSERREYHHEDDAVVNAKVKTALKHGVTPIFCLGEKVDVREAGGHVAFCTDQLVAGLAGLTAEQVRNVVVAYEPVWAIGTGKVASSADAQEVCAALRAKLAELYGEDTAAVVRVLYGGSVKSGSIGELIAQKDVDGALVGGASLDADEFTKLCALAAGGPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T158</accession>
    <name>A0A7W7T158_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCP family protein required for cell wall assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="88"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34125" checksum="2F847199FF5745CF" modified="2021-06-02" version="1">MSVLRAVFRVLISAAAVAVLVVTGYTWHLKHTAEVTVQRITGAITPTEPKSTDGDDESTPDDQGTTILLLGSDARVGADAGSGVTGERADVIMLARIAPHRGAVNVLSIPRDSWVDIPGRGYAKINAALAYGGIPLAVRTVEQVSGVHVDHVVEVGFGVVRELTTLLGGVTVTLPEASTDPLTNTTFDAGENVLEGDRALTFVRQRYGLPGGDLDRIARQHQLLFGALARVRTLNPLGQPLLLDRLTRLVSSSVAIDEGLTVTDLFTLADQVSRIGSGRVRFATAAVASLGTSPDGQSIVNLDADAFAAQCAALARDEPIPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H2</accession>
    <name>A0A7W7T1H2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15671" checksum="627A0D8C2971AD68" modified="2021-06-02" version="1">MPRDRDSSGRARNNRPRDALGRPLPYGLPGVERQPEGVPRTPERTLAEAQRLLDEGKPFHAHEVLEDAWKAAPEDERELWRGLAQLAVGLTHAARGNVRGARALLDRGAASIAPFLDVAPHGLDVAGLVEWADGDVSTVPRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L2</accession>
    <name>A0A7W7T1L2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="15">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">carB</name>
        <name evidence="19" type="ORF">F4559_001960</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="15">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 15" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="133"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="684"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="18">
        <location>
            <begin position="957"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="15">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="15">
        <location>
            <begin position="957"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="834"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="846"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBB4964601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118192" checksum="539AD71B656E70F3" modified="2021-06-02" version="1">MPKRTDLKHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLRVSLVNSNPATIMTDPEFADATYVEPITPEFVEKVIAAERPDAILATLGGQTALNTAIALHERGVLEKYDVELIGADIDAIQRGEDRQIFKDLVREIGGEVPRSAVCKTMAEVRATVDELGLPVVIRPSFTMGGLGSGMAHTHEELERLAATGLAESPVTEVLIEESVLGWKEYELELMRDRNDNVVVVCSIENIDPMGVHTGDSVTVAPAMTLTDREFQHMRDVGIAVIRAVGVDTGGCNIQFAFNPVDGRMVVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYALDEIQNDITGETPASFEPTLDYVVVKVPRFAFEKFPGADRTLTTTMKSVGEAMSIGRSFAEALGKALRSMETKAGGFWTTPDPDTTLEATLAELGAGHDGRLYTVDRALRLGATIEQVHEASGIDPWFVEQIAWLVGLRREIESAPVLDERLLRKAKRAGLSDRQLAALRGELAGEDGVRALRHRLGVRPVYKTVDTCAAEFAARTPYHYSAYESDPDAETEVVEQRDKPKVLILGSGPNRIGQGIEFDYSCVHAAMALREAGYETVMVNCNPETVSTDYDTSDRLYFEPLTFEDVLEVVHSEQRSGTVAGVIVQLGGQTPLGLAKRLEDAGVPIVGTPPRAIDLAEDRGEFGRVLTDAGLPAPKFGTATSFDQAKAIADEIGYPVLVRPSYVLGGRGMEIVYDEETLRGYIARATEVSPEHPVLVDRFLDDAIEIDVDALYDGEEVFVGGVMEHIEEAGVHSGDSACALPPITLGETDIENVRRSTLAIARGIGVRGLLNVQYALKDDVLYVLEANPRASRTVPFVSKATAVPLAKAAARIMLGATVADLRAEGVLPATGDGAKLPPHAPVAVKEAVLPFHRFRTPEGKGVDSLLGPEMKSTGEVMGIDVAFGTAFAKSQTASYGSLPTSGRVFVSVANRDKRAMIFPVKRLADLGFEVLATTGTAEVLRRNGIPCTIVRKHFEGEKNIVDEILAGNVDMIINTPYGNHGPRVDGYEIRTAAVARDIPCVTTIQGAAAAVHGIEAAIRGDIGVRPLQALQAALREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C5</accession>
    <name>A0A7W7T2C5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="SSF50242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031028576" evidence="2">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="19418" checksum="6F812FD68866365D" modified="2021-06-02" version="1">MARLRLAAHAAAALTLSVGLMTAAFANPASACSCFPNDTEGARYQRAQYVFHAQVLKETLDAGDPAQTWDDRYRYTVRPGVEYKGDVPRRLTVTTSTSGAACGIRLSVGQSYLVFAHGDASDGVIETMMCSGTRLSSGGPPNTTPPSATTTPPTTTTAPSTTCATGQTTAPSTAPSGPTTGTPTVPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K6</accession>
    <name>A0A7W7T2K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="140"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22378" checksum="C3C4D58F243D4E73" modified="2021-06-02" version="1">MEKRIRVVVQAADQLSAAGLVGFLEARPEIVVLDADRRDEADVAVLAVGRLDEEVEAGLRRLAARAPVPVVLVLDEIEETDVLTAAECRVVALLPRSGATGERVARGVLAAASGGGVMPPGMVADLLDHVRRLRRQLTAPASERGRLTTREVEVLRLMADGLDTAEIATTLSYSERTIKNVFYGITSRLNLRNRPHAVAYALRRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z3</accession>
    <name>A0A7W7T2Z3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein YphA (DoxX/SURF4 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15671" checksum="378871F88361BF9B" modified="2021-06-02" version="1">MTNTPGHVGVLDRAETLLARLALPCLRLSLGLVYLWFGVLKVVGRSPVADLVQATLPWVHGDWLLPALGWVEIVLGIALVVGRPRRLAPAAAAAHLVGTFLVFVEAPALAMSDGNVLLLTTTGEFVLKNVVLVCAALAVVGWGRTARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T384</accession>
    <name>A0A7W7T384_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="166"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="400" mass="42182" checksum="FF1431C537DFD91E" modified="2021-06-02" version="1">MTEIHRGTVGGLTVLCVPDHRLRTVSLALGLAYGARFDPPGQGGVAHLLEHVLMAGETGREHSFCEQVERLGGHANAQTAPDTMAFYAQVAAEDVDRVAPDLCAAVLAPEIGAADFDREREVVLQELAGAAADPGDVVQDAFLAAAFAGHPLGRPVGGVPDELRALNLDDVVTAHERVFSTRPAALVAVGPLEVDRVVDLIAGAVPRRRAAEFVPTTPEPLSPVVADGPHDGFSWLCTGSRAPSRHEGDHSAYVVLACLLGSSPASVLYRKLRVERALSYSFQAWTTAYAESGVWRVLVGTDSSTVDDCRVAVRAALTEMATGGPASADLDAARRQARMDLVRTAEAPLDLAVHLLKRTWAGAVDWTVDGGIAGVTGVSAERVRLAARQVLDGLVEVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T386</accession>
    <name>A0A7W7T386_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7357" checksum="CDD69CD990CA869E" modified="2021-06-02" version="1">MSMHPGFGISSFARIESEAPISCHVVGDEAHLTIGGALDLVITKAALVDLTGHLVRARDELTADEQLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T398</accession>
    <name>A0A7W7T398_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase (APT) family kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26614" checksum="4F090D9F710E9B59" modified="2021-06-02" version="1">MDPVKVVVAHDERVTLRVGDVFLKVDADRDRTDDEVAAMALAPVPTPRVLWHTPPVLALAALTGTALGRLGEPSTASAAAWVAAGAAVRRLHDAPPPPRPGPGPDELAARLAAECEWLTAHDVLPAEVITRNRRLAETALRPWTPVFVHGDLQVDHVFVADDEITGILDWSEASRGDAHFDLAVLTLGHPEHLDDVLTGYGTEIDREPIRAWWAFRCLTNIRWLAEHGYGSPGGFPESAVLESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3F1</accession>
    <name>A0A7W7T3F1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031448631" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19206" checksum="83F69AD630A98BDD" modified="2021-06-02" version="1">MKKSLRRLLMVFLSVAALLGALPAASALAAEPPLYTDLLFENKASGKCMNIPNGATFDGAPVTQFSCGVWADHKWMLHDRGNGWYQITNGASGKCLAVPHGTTTRGVQLIIWPCGGYEDHHWRFVEYPDGKRQVVNMKSGQCLAVRDGNRDDHAAVIQWPCGSWPDHFWKLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3H0</accession>
    <name>A0A7W7T3H0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="32742" checksum="42F7A7A2EABDA9F2" modified="2021-06-02" version="1">MPTKSPLEDEVADAVARLMRRGLPVTLAAVDPVLLELRGVLARAADPGDEASRIAALDGTLRGLLARFPDARYAAAARALFGLPPAVPGMNLTVRRELAAEQAGHEVHHFRKRVEPKLVTTLAAELLADADRFTRSPLIAPRLAPVTARQPVLADPFAWEVAEQEEQLSLLWSAIYAARAELLTVERLISLHSERTDVIRAAVTAAWRWAAARAEAISYTTAFAPDLAVHELVALAGWTPALSAGQTSRLTEAAAGGASREAFVAHLHGETGLGNTWTEGFLAALPSPEQARTVPSTPVPPDPDQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q0</accession>
    <name>A0A7W7T3Q0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superfamily II DNA or RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="419"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="696"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="864" mass="93558" checksum="7FD10F2C137AE27A" modified="2021-06-02" version="1">MVFYGTGDERAVVAVPEGGTREVPAVRLPIARAVPVLSRARRAPDAHPAAGFWGAVVVAALRLVARGRVRPAVTDGDFDAWRVGPLDAADHAAVAALARAMPAHARALPLPGTSPAELPDAEPLIRAFFDAVADGLPRGSAAVHAAGTPEFTGHEPRKVPHLRAWADEGVRISLRVEGPDEFRAVVQVHSLADPTSVVDAAELWSGASPRTRSAATVAVRRAARAWPPLEELLHRPVPDGIALADADVTDLLADGVVLLSAAGVDVHWPKDLVRDLSARVVVHADRGDRPSFFGPDQVAAVDWRLALGDDPLTPEELDLLAQAHRPVVRLRDRWTLVDPELARRARERDLKPMSAIDALGAALSGSTEIDGTRVEVVASGWLEDLRERLSAADLEPAEQPAALAATLRDYQLRGLRWLDRMTSLGLGGCLADDMGLGKTITLIALHLHRGGGPTLVVCPASLLGNWQREIERFAPGTPVRRFHGTGRETADTGFVLTTYGTMRLDADRLAEVEWDLVVADEAQHVKNPTSDTARALRRLPARARVALTGTPVENTLSELWAVLDWTTPGLLGTLPAFRARWIKPIEADRDEAAARRFAALIRPFLLRRRKADPGIAPELPAKTETDRPVALTREQAGLYEAVVRELMAEVADATGIARRGRIVKLLTALKQVCNHPAHYLRESAPVLTGRSGKLELLDELLDTILAEDGAVLVFTQYTAMARLIGRHLTARGIDSLFLHGGTPVAAREDMVRRFQDGQVPVFLLSLKAAGTGLNLTRADHVVHYDRWWNPAVEDQATDRAYRIGQTRPVQVHRIIAEGTIEDRIAEMLRAKRSLADAVLARGDAALTELTDAELADLVALRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S8</accession>
    <name>A0A7W7T3S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25024" checksum="F38502475E38D054" modified="2021-06-02" version="1">MHDILGDLPAARRIPAAKAESMRMGIERAVRARPRRRTRRGWLLVPAGAVALLVAVLLVADVLVTPQPAYASWTAEPSGLGPAETAALGTRCADDVRDAFPDAASDLRPVVGERRGVFQTALVASGRQVALCADWLGVRDGDSVRGGTLSGLTPDAALAPGEVLQTVAVPGQASGPDAARIAYGLVSPEVSRVTVDTADGRHVTASVHDGYFLAWWPSGADPEQVTAFDSAGRALVPPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U1</accession>
    <name>A0A7W7T3U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="35" mass="4091" checksum="CE46E08C27326D8C" modified="2021-06-02" version="1">MPYPRYNRTPDFLAFHLEVCTIAEDLGERLTKVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T459</accession>
    <name>A0A7W7T459_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Light-regulated signal transduction histidine kinase (Bacteriophytochrome)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the phytochrome family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PHYTOCHROME_2" evidence="8">
        <location>
            <begin position="144"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="518"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="729" mass="78118" checksum="233A308DC1FAD112" modified="2021-06-02" version="1">MDERELAAETAFDLSVCLAEPIHRLNGIQSYGALLAVDAAGLVEVASVGCADVLGVVCGPGVPVVDVVGVAGWADVARTLAAPTGDRGVLGLTVAGGAFDVTVYRSDGRVVLEFEPPTAGRPFVFSQFYPSVRTALTRLQHERTVVDVCAAAVAEIRALTGYDRVVAYRFEGADGPGEVIAESVAEPVEPWLGLWFPATDIPPQARRLYERNWIRVIHDIDDVTVALDPPVLPDTGLPLDLSDSTLRTVSGFHLEYLRNIGVASSMSVSLLHEGRLWGLIACHGLAPRRLSAEVRAACEFFGVTLSLQLAAMQESEVDRARSAARSALSRLVAELDGEVVAAVAAYGDLLAALVPADAVVTRSSVVGGRPPGETALRALWEHVPPLAAGQVWSRDELPELAAYAEELSGVLVLGLDDDGGAVAWTRRERRAARTWAADPGVPVRLGPHGERLTPRGSSAVYREVTRGRCVPWTDADEAVARELGYAVTRQAARNSARLAALNDELRRANHDLDAFTHVAAHEMKEPLRGIATTAAFIGEDAEDLDPVTRRRLDTIQGLAQRMDELINSLLHFAQLGQADLRRAEVDLRAAVGQALEIAGPRLVECRVELIPPPPGTTVTADPDRLQEVLINLLVNAAKYARADLPRTVEVGVESSAVFVRDNGIGIPLTHQDEVFRLFRRLHPREARGGGHGAGLAIVARIVERHGGTLWLDSTPDAGTTVWFTLPGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T496</accession>
    <name>A0A7W7T496_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="17908" checksum="1E63D34C4CB41CAC" modified="2021-06-02" version="1">MPMLPDAPVTGTRCPGRTESLSRRKYGAVVAPSTAAADSANDRRVGLGASEPDAGMRAYSACPPTAKPVNPNTSSPGANRVTDDPAESTTPATSRPGVRGPRRGRRRPRITRPHTGSPRRMVHSADVTVVAWTLIRTSSARGTGRGASTTSTTSTTSAGPNPVWTEAFMGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C9</accession>
    <name>A0A7W7T4C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="31282" checksum="3C2AA301B422DF0A" modified="2021-06-02" version="1">MTTQPVRPRRIPFRLEVLSGEAVEVVRRTFGRCPSPVVAHVFSAWGAALAATAGAGSVTVVHDCRPLPGPPGAAADHVLVGSHAEAEAVTGPSRPSVDVIARAVDQRRWNPDGPTAPRGEAPRLLVTSALCPGDGTDTAIAALSGIPGAELVVAGPTGSPLPAHRAEIRRLLDAAAALDVADRVRVVTGPTPELVRSADIVLHVPWSTMPPDPVLHAMACAVPVVAATTGALPETVLDGVTGALVAPRDPAALARTVRRLLADRSRCAALSAAALDRVHLRHSWAQVATDIHHVYRRLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K2</accession>
    <name>A0A7W7T4K2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025349">
        <property type="entry name" value="DUF4253"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14062">
        <property type="entry name" value="DUF4253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4253" evidence="1">
        <location>
            <begin position="173"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="30161" checksum="5F4C3F1C77AA6519" modified="2021-06-02" version="1">MSLEPLPEALRGLFAADPAGRTLSVPLPPGRTVLSTEERGDRPALWLGDGPVPAGLWATLRTEHPKSGLWPLLLDALDDDHDEYRPWANGEVAPGAASAPGNHDAAALLADWWAVYAGEHENDDLPVEELRAITAPFGLAWPGLAPGRPHRTDPDRTADDLAAQLLAGHPSLRLGLVAADRGADALAAVGWTGPINHTEDTAEVSAVVRSWEDRFGARVVGVGFDTLLLSIATPPATTVEALAVAAEHFAFCPDNVWVGDGPQTLAAYAERLVGDHSWTFWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4L0</accession>
    <name>A0A7W7T4L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031227556" evidence="2">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="18799" checksum="AE13AE4F287E1944" modified="2021-06-02" version="1">MRRLLLAVAALAGSLVAMRAATSTFYDAYGVGILNIGGGRDLTSSGAAGYSADTAYTWLAAYGPSGRDDHLLILLLDLPLIASMTAVLVLGTRLALKGLRTTRTLRGVLSAFPLAGVALNLVEDLAITGLVSAYPQRLDFVAGIAGAANAVKSVSYGLAVATLVAALGARLLWRIRCAGRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M1</accession>
    <name>A0A7W7T4M1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18121" checksum="ADCC4D1FD9360B66" modified="2021-06-02" version="1">MTDVHRFEVFADFSQFMIADLRPHHAWLDTDEGDDDEPAGWTEEAVLVHRLGVQPHQLAIATDRPEVAETVEVVLHVGRTPPGDLLPEAGHVVEADLSLPTGVLSVFGPSDDEHAMRLVPLAPGRYRARVSHLPARVYRVDLWPATEAVGVVVLVQSRPDLFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5A2</accession>
    <name>A0A7W7T5A2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="8" type="ORF">F4559_004192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="7">
        <location>
            <begin position="31"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22439" checksum="707427BAD0865659" modified="2021-06-02" version="1">MTNTLNKLAPSERQDLVPPGPVDTERVADLVGQLLAAIGEDPGREGLADTPARVAAWWRSFFSPEPSAAPTSFPEQHVSGQLVVIGGMSVWSLCEHHLLPMNLDVAVGYVPDGEVIGLSKLGRIAQQYAGRLQVQERFTRQVADEIAVVLGSPDVTVAVRGTHLCMSSRGVRMEAARTTTLQAGGRFESDPVLSQQFLALATDRWRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C2</accession>
    <name>A0A7W7T5C2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7842" checksum="2F81029306FDFBBE" modified="2021-06-02" version="1">MARCLRTGLQRLSCERKHNCGKDTWSGRWPGEVDCERLGWMIGPGLPDLNRLLTEATWNPATQQWDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C4</accession>
    <name>A0A7W7T5C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall-associated NlpC family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030641974" evidence="2">
        <location>
            <begin position="28"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="165"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="35746" checksum="0F9B3CF4441B4D4D" modified="2021-06-02" version="1">MARRRALWVVVVAVAILAAGLTVWLSRDDPAHIAVDVPDPAALSYDRADNPPRTIVRDGTGAVVAVLTDDARTAVVNGPRRTFSEPKSTSATVDTSAWVRLLPRPWRAGAETDEWFREWFTPTRTDTRPDVLATAMEYVIDAPEEKDAAGVRFRGDASFGPVKPSGSGRQEQSDFYDYLGIDWKFPDAPDGEPETGRYGSVDCSGYVRLIFGYRLGLPLLGSNEEGDGLPRRAYAIADVGPGVELVPDGGTRATDYGALQPGDLVFFEVEDDPDTLDHVGVYLGVDDGGHHRFVSSRERINGPTMGDVGGASLLDGGGFYSTAWRSARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F1</accession>
    <name>A0A7W7T5F1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="37425" checksum="D022F93B14A031C1" modified="2021-06-02" version="1">MSSREAIPRSGFERDSMPLDAARSAFEWLVAGPHPVSVDGRLFPGLPARRVPLNELRDLLLRRRCPQTLRDAAWAHLVLLARTEGGTWTVGAVGVALPALTSIAATLSAKFAGDPSDIHAAVLAGFVAELGEIDLRRPRVMLRLRWAAYRAGHTAVREALDAPVPSGHGFRSTMPPPPWGHPDFVLARAVAEHAITAAEAELIGSTRLEGVPLADAAAERNLSYQAAKKARQRAERRLVAYLLDDTTDTPHTGPHEGDVANQVADAVTITAAAQHSIADASLSRSVTDLAARTAKKVGDRVSPQGRFSGVQGCGRKPATPAHTTSSPTPPRESTQHSEQRPSGTTPGVSRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I3</accession>
    <name>A0A7W7T5I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="9965" checksum="9D23E15F62CD3BF9" modified="2021-06-02" version="1">MIKTFLETGPGHLKARVGALPLGGDADEGVDHQVVDWAMGGLPDAAARDVEARVHGYLQEAADLGSALAKRQCVLWLVACVPVLLLIGLLFKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I9</accession>
    <name>A0A7W7T5I9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="12"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26921" checksum="3E476441DC40D8D8" modified="2021-06-02" version="1">MSLATTVSDSATMLRRNLRHTLRNPVTLFGSLAFPIIMLLLFVYVLGGAFEVGGDYLDYVVPGMLVLSMGYGVTYTAISVSGDVLGGIVDRFRTMAVSRAAVLTGHVVGTLLRTAVCTALMVGVTLLMGFRPDATVVEWIAALGVVAMLVFAITWFTVALGLAAGSAEGASFAAFPLTFLPFLSSAFVPPETMPAAVRAFADHQPFTPVIETLRGLLTGTPIGHSAWIAALWCAGIALVGYLWARARFTRDPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T631</accession>
    <name>A0A7W7T631_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="547" mass="60120" checksum="FD019DB68DC30507" modified="2021-06-02" version="1">MLEFDQGGEPVTRQALTVEELRRFRFSRLGPEGPSFDEETRIALATAITAAVPQPDSTDPAIPAGFTYLGQFVDHDLTMDRSESKLGDDVDTDDLVQGRSPALDLDSLYGRGPRDRTDREFYAADGISLKMGTTSRTTFPDAKVDIALEGFDLPRKGGTDGTGADRRRPLIPDTRNDENLIVAQTHLAFIRFHNRVVEDLALRGLSGKLLFEAARDLVVRHYQWMLRTDLLPRIVDPAVVDDVFTHGRKFFEVPGRGFTAHGNRPTMPLEFSVAAYRLGHSMIRGAYQWNRVFNSTGPGPIASLLLLFTFTGTSGNFDPTSGLPELDDPNSSTVHTLPTNWIADFRRLYDFTEADRDDLVPPADSGGGNVTKRIDTLLVDPLTQLPAGTFGGRGTTIRDIERNLAFRNLTRANMVRLATGQQIAELFGVEPLTPEQILTGDGGADFSALTDEQQAFVGGNTPLWIYILREAEFNGGLLGQVGGRIVAEVFHRSMEASRTSIVRTPSWRPVYGPDSATFRMTDLLLFAFEGKADLLNPLGDKPTTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T657</accession>
    <name>A0A7W7T657_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="entry name" value="PTHR35040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030546807" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="290"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="504" mass="53967" checksum="A1B4253F23B58077" modified="2021-06-02" version="1">MTRLSTVSARIGVAVATVALVAPAPLAHAEPVQHAAIPAYWSPDTPDGRALFHRLAGNHPTTGIVVVNGSLSRPEAPHDAAWADAISTVHASGARALVYVDTGYLGVDLGQGSHHTREGEISPEAWLAQAKVDVDGWYSLYGDIDGVFLDQTLSACGPDNLHVRHYADLVAYVKAHHPGAYVVLNPGRAVEECYADVADTILTFEGSRAAYLAHTPPAWELARPDRKKFWHLVYDVPADAMPAVVARSKANGAGYVYVTDRAHDPYPWDTIATYWDEELGHVAGVEDVTSPETPKEIRAAVSPTEVVLRWTPSRDDVAVVDYEILLGRTVVGTTFDTAYTATGLVPGGTYTFRVRARDSAGNTSATGNPVTVTTPVPQVHHPTACVTATSARYAASFVREFPHQRVFVDSDDDATTGYPLPPGLPQGVDHMIEGGVLYRHSGAGWTWTAVTDVAVTSADGTTTWELPTSAYGQVATRQVVVFNGYDGVDEYSEPITVTIGDTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I2</accession>
    <name>A0A7W7T6I2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">F4559_003479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="118"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="27606" checksum="ACD6A128C379AD2E" modified="2021-06-02" version="1">MRRIDGRAIAATITAEVTAAVATASVPPTLAVLVPTRDEATAWYVRSIERAARKVGIACRVVQLEEPSRQDVVDRLADLSADPSVHGVICQTPLPDGVALDDVGAFIDPRKDVDGANPESLGRVAAGLSGFAPATAVAVLEVLRHEGVPLAGTRAVVVGRSTVVGKPAALLLLAADATVTVCHSRTADLPAVTREADVLVVAVGRAGFVGAEHVKPGAVVVDVGTNPAADGSLVGDVRPDVAGVAGALTPVPGGVGPVTTAVLLKHTAQAARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6R4</accession>
    <name>A0A7W7T6R4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031047466" description="LytR_C domain-containing protein" evidence="2">
        <location>
            <begin position="42"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="100"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25353" checksum="75C67BE92877C712" modified="2021-06-02" version="1">MGPGSASAGSSRYRKRRPVPALVLFLVLGVTAVVVWNGVLADAGDVDAAIRCNTPGNVPSSVVPTGEPAGETMPQAARGTVLGHDALDRTDPVPASDVHFRVFNASTQRNQARFVATTLTELGLQQAAEPDNDPVYPAQDMECRGQIRFGAPGAGAARTLSLLAPCLELVRDERQDATVDVSVGKKFSELKPNHDARKVLDGLTAWAEQHPDRQGGQAADGNPPPSIDQDHLDAARDVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6V5</accession>
    <name>A0A7W7T6V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="23524" checksum="4D71CC5756DA6821" modified="2021-06-02" version="1">MIPRLAVVPHPPLLVPELVPGAVADTAAVRAACVAAARELTALSPDWVAVGVDPSGPRVVERVTSTFRGFGVDVPVRLSDDAVDHDPELPLPALVAAWLREQAGARSVRVHLVAPDTPLDECLALGADLAGGPLLVLGDGSHRHGERAVGRADERAGAFDDEVGRALAEADRDALKALDTDLAAELGAAGRAAWQVLAGVPGDWRCVRSEFSAPFGVGYHVAVWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y7</accession>
    <name>A0A7W7T6Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="631" mass="68189" checksum="32FF6F5CC8581538" modified="2021-06-02" version="1">MRWDGQKERQPALPGLVRSVRTPEFDGVVFHEVHAKSVLNRVAGGRLPFEWTVNPYRGCTHGCTYCLAPETPVLLADGRTRSIADLAVGDEVFGTRDGRFVRTKVLAHWTTVRPAFRVTLADGSSVVCGGDHRFLTGRGWRHATPGRCDDAVRRPFLVRGDRIAGFGGFARGPRFDADYRRGYVLGAVRGGLPGDSGVAARVREYAGGRVPRENELVEWPADPGPEWSKGFLAGVHDARGTATGDGVALSCSDGSVFEAAVAALTRLSVPHAVEVRGVRVAGDAGDRLRFLHLVSPVLMRGDVVAGAAVSVDSTRLGVVSVEPLEADRTLFDITTGTGDYVANGLVSHNCFARQSHTYLDLDAGRDFDDQVVVKVNAPEVLARQLRSRRWERHPVALGTNTDPYQRAEGRYALMPGIIRALADSGTPFSVLTKGTVLARDIPLLASAAKRVPVGLAVSIALLDRELQSGLEPGTPSPRARLDLVRRIRDAGLPCGVFVAPVLPGLTDSIEGLDALLGEVAAAGATGVTVFPLHLRPGAREWFARWLLRERPDLADGYRRLYGNGSYVDAKYKRWLNLRLSPLLRRHGLETGNRIATADSDAESNEDGAWPAGSLPPSLPRPPVDRDQLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T724</accession>
    <name>A0A7W7T724_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="107"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="20837" checksum="135268B9D572CC61" modified="2021-06-02" version="1">MIALGVLFVLASVGLGVLVRHDVPVLDRDLHEVALTLGPAVTRTAEVISLVLSPGLATITLVALGSRALLARDSLLVRASVLFGLCWTTVLARDLYRRIRPIEYDLYSYPSGHVTAVATMGFVGVLLTAHLARDHVRTAIVLAVTAIVLTAASRVVVQYHWFTDTVGAVLGVMGVGLLGAHALRLTPVGVGSRSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7J2</accession>
    <name>A0A7W7T7J2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="32183" checksum="8D99AD33DAA6A803" modified="2021-06-02" version="1">MTDLMIEAHGVVKAFGAHKALDGVDLAVPRGTVTGLLGHNGAGKTTLVNVLTTMLPPDGGRARVAGFDVVTQGHDVRGRIGLTGQFASVDESMSGRDNLVLIARLLGAGVREARGRAAELLELFDLSDAAKRAARTYSGGMRRRLDLAASLVGSPEVIFLDEPTTGLDPAGRLGLWEIVEGLVKEGSTVLLTTQYLEEADRLADSITVLSQGRVVASGTSAELKDRVGRRTVTVTLADHADVPAACGALEHAGLEPVAADNTLTAPVTSSRALAVVVRALDEVGLEASELALGEPTLDDVYLTLSRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y4</accession>
    <name>A0A7W7T7Y4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030826816" description="NlpC/P60 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="206"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35471" checksum="B569FBCDC66C7EE2" modified="2021-06-02" version="1">MLKIVLAVTAVVVVIAVAVVNGVQTAVSGSTPVEGMNIRSVGCNASIGPWEGGGEERGRGDASRLSGEQRKTVGMIISIGQELKLPPLAWQIAIQAGMTESGLRSLDYGDRDSLGIFQMRPSMGWGTPQQVTDPDYAIRKFYAVLLNVPGWEDQRPGDSAQDVERSAYPDRYHRWEAMAAFMIGELGDVPDPAGCGASAGNFLVASGAASTAIEFTRQQLGEPYLWGGNGPDAWDCSGILVKAFGAAGVKIPRVANDQYMSGGAHLPVREAKAGDLIFWATNPANPVTVHHVGMYLGNDQYIHAPQTGDVVKISKINWDYYELMPLAVRPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y5</accession>
    <name>A0A7W7T7Y5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17896" checksum="D74C16A81C47CF6D" modified="2021-06-02" version="1">MERRPATEAEAAALASAVRLRIIRLTGEVPLTNKELAERLDRDPATMLHHVRKLVAAGFLEALPPRPGNRGAKEIPYRSTGLSWRLSHDADPPSIAEAMLEAYLAEVAELPEGVMDQSRLVVRCDPGELKRRLRSLLDELAAEPDDPEGERLALYLAVYPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T839</accession>
    <name>A0A7W7T839_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trpD</name>
        <name evidence="6" type="ORF">F4559_005096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="78"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="111"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="35762" checksum="23F234D0765CD77D" modified="2021-06-02" version="1">MTALSWPSLLSRLVDRGDLSEEDTSWAMDQIMSGAATQAQIGGFAVALRAKGETPAEVDGLASAMLRHARRFTVDVRSMDVVGTGGDNSGSVNISTMAALVTAAAGVPVVKHGNRAASSQTGTADVLEALGVAIDLPATGVQRTLAELGIGFCFAPIFHPAFRYTSGPRRELGIPTPFNLLGPLTNPAQPDAGLIGCGRDGVGGLIASVFARRGKTALVVRGDDGLDEITTTTTTSVWVASGGSVRTDRIDPSVLGVRAALPADLKGGDPALNAEVVRDFVGGKPGAVRDAVLLNAAGAIATFAGFGPDLHADLAAGLTRAAEAVDSGATATLLRTWATLSTTLKAELPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T896</accession>
    <name>A0A7W7T896_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="273" mass="28525" checksum="F39688A5D878F531" modified="2021-06-02" version="1">MDEFTEMEELCADAWPAPVELRLGSWRLRAADGFTGRANSALTLGDPGRPVDEALAEVIAFATAHGIRPAAHVVVGSAHEAAIAGAGWRVDEDHPGGAESAVLTASPRTFATPKTPNAAVYPHPPTAWWALTADAEPTAAQRFVLGGGRTADHKATPDRPPGTGRGPASHRACEVGFGVVRRDDTVVAAARAAVVGDLLHVARLAVRPEARRGGLARSLMGALGVWGCERGATRCALQVATGNTAALGLYAALGFTEHHRYRYWVADSAANHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J1</accession>
    <name>A0A7W7T8J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="532" mass="59968" checksum="D31909FAB6F67B53" modified="2021-06-02" version="1">MNGGTRAERMRQPMALDVAKAAAEKYGVCVRPFTMEVEDRESFEVRYVAVPCGSTVESVCGPCARKARALRMAQCREGWHLTEEPDLTPRRPSEDETALTTFRADLVTAYREAVGSGEAGHADELREEVHSVDAELRQLGVRGRLPSPDLPAARPVKRSTKRRQDAPDLPRRRVEKRTVGREYAGRFRPSMFVTLTLDTYGRVHDDGTPVDPTTYDYRRAARDAVHFASLVDRWWQNLRRVAGWDVQYFATVEPQRRAAPHLHAAFRGSLPHATIRLVTAATYHQVWWPRHDEPAYDRDHPPVWDARADAFVDPDTRRPLTLWDDAVQAADEPAHVVRFGRQVHSKGILGGTEEAGRHIGYLCKYLTKSIGEVVDQRTDRQRRHADRLADELAVTPCSDRCPVWLLHSVQPRGAGPRTIPGHCKGRAHRRSTLGLPGRRVLVSRKWSGKTLADHRADRKRFVLDALAAVGIEKPEPDTSRLVWHKVRPGDPNVPPRAHQLMHAIAERTRWRAEYDRALLAAAGPPEVSAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Q5</accession>
    <name>A0A7W7T8Q5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16127" checksum="3E4E9C73EDC5F522" modified="2021-06-02" version="1">MAITGGSRLPTPHDFVFPRGALVMGVEPVLKFQSAEERTKGLPVEQETDKETGMLVWSVLVIDQAADRKSDAAVTVKIAAAHRPVPPEAIPGTDVRPVVFEGLTVTPWIDDKTCRGSHGGERHRCRAKLGYSLRASGMKPVVVKTSSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T901</accession>
    <name>A0A7W7T901_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40326" checksum="AFD9F6BF3057C409" modified="2021-06-02" version="1">MVQQKEEDGFRPGLEGVVAFRTEIAEPDRDGGSLRYRGVDIEDLAGKVTFGNVWALLVDGRFGPGLPPAEPFPIPVHTGDVRVDVQAALAMVAPIWGYSPLLDITDEQARDQLARASVMALSYAAQSARGIGRPAVPQRRIDECRTITERFLTRWRGEPDPAHVTALDAYWVSAAEHGLNASTFTARVIASTGADVAASLSGAIGAMSGPLHGGAPARVLPMIEEVERTGDARAVVTSILDRGERLMGFGHRVYRSEDPRARVLRRTARELGAQRYEAAAALEQAALAVLRERRPDRAIETNVEFWAAVMLDFAQVPTHMMAAMFTCARTAGWSAHILEQKRTGRLVRPSASYVGPAPRKPSDVEGWDEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T926</accession>
    <name>A0A7W7T926_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="78"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="487" mass="52184" checksum="035856666E4B2ED5" modified="2021-06-02" version="1">MRAVLAVVMLVGFFVLAFGMTFGLGAAVVIAFTTGHSGVGVAKAGILALVVAFAVGGALWKALRTKDEAEGAPLTREEQPRLWAAVDELAAVAGTRPPDDVRLVPSVNAAVWEKTSFLGLKPGPRHLMIGLPLLAGLSVGEIRSVLAHELGHYGGGHTRLSALTYRAKNALAATVENLDGNLLRYPLYWYAQLYAIVAASATRRQELEADRASVVAAGRETAQSALRKVLSLDVAWNVYHENYVSLSLAAERTPRVMVGFRAFLGDPTRQEQLAEVQDRLVDEESSSVFDSHPPIRVRIKAMDALPAADVPRDDRPGWTLVDGIEEMEKGLIRDDLGPVADWPELVERAGAAQISHYANILAEAGRASGIAPHGTSDEIIASLARGEALEALRPHVVDPALTGNEMVTALLEVVRELLAALVVDELVRAGRARFAVNWGREWDVVVDGRAVDVPALVAPVVVDPREAGDVAERILALRGGSDLRHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K4</accession>
    <name>A0A7W7T9K4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4822" checksum="0EF117212E4B3F87" modified="2021-06-02" version="1">MLSDSPREYQPPTEATRPSVRVVSFGYLHVHLPRVLTEGGERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V9</accession>
    <name>A0A7W7T9V9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="14"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="27177" checksum="34A07AB9662867BB" modified="2021-06-02" version="1">MSTVDIGLARGGVELRQFFRDRAGMVFTFALPAFILMLLGNITGDAPGAGQSLAASLLGAGIISTSFITLGVGVAQDRGDGTLKRLAGTPMSPGAYFVGKITLVGLLSLAEAVLMIAVGVAFFDIELPTSLDKWLTFTWVFVLGVVSCGLLGLAIGGLVKSARSAPAVMNLPYIGLQFVSGVYVALPMLPKAMVTVASFFPLKWVAQGFRSVFLSDDMAIQEAAGAWEHGRTALVLGAWCVVGLVLSLLVFRSSSRRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA13</accession>
    <name>A0A7W7TA13_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32155" checksum="DF8E85D3D3B4F10F" modified="2021-06-02" version="1">MDLDGVRTFVAVVDGGRFQEAADELSISQQAVSKRVAALERTLGVRLFTRTPRGAVLTADGLAFLPHARDLVAAVARAWGAVRPVRALRVDVIGTRLAPAALVREFHRAHPSVALDVVTHFDLDAAVAALRSGSVDASVRAADRLPDGIEAVRVFDEPIQLLVGPGHPLADEPWVRPADLAGHRLWMPGLVAGTEWAAFYDAFAAEFGVTIESAGPHFGIETLSVALAARPGTATLVGEWTRIDDRGLRRIALREPTPVYPHSLLWHRDNRHPALTTLRSHFIKSEHTYQVLQATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA58</accession>
    <name>A0A7W7TA58_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_006221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="37"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="31305" checksum="96D1AB5837B85111" modified="2021-06-02" version="1">MSLDADVLIDWFTDTARDLPWRRSECTAWGVLVSEIMLQQTPVARVEPVWRSWLERWPLPSSMAAASQGEVLRAWGKLGYPRRALRLHEAAKAIADKHDDVVPEDVDTLLALPGIGAYTARAVAAFAYGQSVPVVDTNVRRVVARAVHGAGDAGPPSTTKDLRDVEALLPDEKADVYSAALMELGALVCTARTPKCADCPVIEDCAWQRAGRPAYAGPAKAVQKFAGTDRQVRGLLLDVLRGTVEPVAKARLDVVWHDAGQRDRCLDSLLVDGLVEQTAGGLFALPGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA90</accession>
    <name>A0A7W7TA90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pilus assembly protein TadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="47"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="18837" checksum="1831D190267E6653" modified="2021-06-02" version="1">MIFLLFALALACYPRRPVIDRLRAPRARRVRGGAGPPDPLALPATWDLLAAVLTAGLPVATAVRAVLPGVPPAPAEPLRRVADLLGFGADPVEAWAPALADPATASLARAARRSARSGAALASAVKDLAGTARVEADNRSEARAQRAAVLVAGPLALCFLPAFLCLGVAPVVIGLARDVATHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB44</accession>
    <name>A0A7W7TB44_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_006716</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="304"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="594"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="880"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="901"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4969357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="971" mass="103967" checksum="3CD014507B3A4E16" modified="2021-06-02" version="1">MNDQYDDRQRGGEPQWPTGEDPDGGAQRPDDRPRGGPGPRQGTPPGGFDRPRGGPAPGQDGGPGGQRRPAAPGPNGSRGPGPGDQGGPGPRTGGRPGPAGQGGPNGPRPGPNGPGGPGPNGPGPVPGGPGPHSGPGPNGGQGTQRMDTPPQRPAPPGGVRRPMGPGGPVPPGGRGPGGPRRPGGPGPDRRPGEEPTELLPSAHQSSRREPELLTHREDELLVDPVDDDEEYEDDDELTDEEQRKQRRKKIWRRVRRTSYVLLGLMILGPVVAFAIAYQVVTVPVPEEVAANQNKAVTILYANGDVMTKIAPNGANRTMIKYEDLPEHVKQAIYAAEDPTFETNPGFDFTALARAGWYQVTGRDSGGSGLTQQYVKKATENDAPTLSRKFTEIVKAYKMSKQQGKEEILTAYLNTIYFGRSAYGIKTAAYMYFGKNDLKELTPSEAALLAGMIQNPSKSENTQYSKDRWEYTMRQMLKFKWIDQAYFDSQTYPAPKPLEELQQHGLDGTDLFIRTMVMAELEAKGGFTESEALRSGITIHTTIDPVMQDKADAVIKNVMKGQPENLRYSMSAIDPTTGAVRVYWAGTDLNIDYQTGTLQEPGSSFKPFDFVAALKQGEGAGEVYDGSSPREFPGRTGRNAVFNSPNVACEVPKHCSVREAMVRSVNTVFFDMVATKYGPQAVADSAFGAGIPKEVELADGPHKLLAADEKDGGVTDANISIGGGTTRVRPFDMTAAYASFASRGVYREPFFISKITDAAGDTVYTHVDKSKPAFDADQKKSEDIADNVTDVLKDIPGRSKNTTCSAKRACAGKTGTHEKEGSSENTRAWMVGYTPSLSVGVYMGSESGKDAIKNAKGEDVYGSGLPGQIWRDFIDQALADKPSEPFAKPNPIGKLSAAPVVPSTTAPKTTTPERTSQTPTTTSEPEETTDRPTGTKPTRPCMPPLCPTGTTQPTKPTLEPTDPIGNGRREDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCL2</accession>
    <name>A0A7W7TCL2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">F4559_006644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="47" mass="5451" checksum="703DAE3AEF62EA85" modified="2021-06-02" version="1">MSKGKRTFQPNNRRRAKTHGFRLRMRTRAGRAILAARRGKGRKELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TD18</accession>
    <name>A0A7W7TD18_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dienoyl-CoA reductase-like NADH-dependent reductase (Old Yellow Enzyme family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="354" mass="37321" checksum="77AE070C0D4D16A4" modified="2021-06-02" version="1">MSPLFTPLSLRSVTLPNRVVVSPMCQYSAHEGYPNEWHLVHLGSRAVGGAGLVLSEATAVNPIGRISPEDTGLWTDGHVDAWRPITAFIRAHGSVAGVQLAHAGRKASTYAPFDPRSGGVPDEDGGWTPVGPGTEPFSAALRVPAPLDEAGLTEVVRDFARAAERAVAAGFQLVEVHAAHGYLLHEFLSPLSNHRTDGYGGTFDGRARLTVEVVDAVRAAVGPDVPVLVRISATDWVEGGWTVEDSIRLAPALVGAGADLIDVSSGANVPVADIPVGPGYQVPLADAIKRKADVRTGAVGLITDAHQAERVLVDGSADLVLLGRELLRDPYWPLHAAQRLGAQVALPKQYARAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU7</accession>
    <name>A0A7W7WTU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="10495" checksum="71CEB3D9BDD5C8D4" modified="2021-06-02" version="1">MTTTPDRKFEVTVGKSEAALLGPSWETGFARRTVQRIDEQATTDEAIAQGIAEGVMVLHSIRRILIWTAVIVPTLITGAVIVLMAVGGESSCTSVYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU37</accession>
    <name>A0A7W7WU37_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11571" checksum="0096E2AA86F30918" modified="2021-06-02" version="1">MKKTNRELLRETVSAALGLGWCVVVAVEADRWSDVARDVRWPWWLAPAVAPAVVVVVLGGMRLIEVGVAGLTGTEESMMPWGVWVRPWSWLRWYRDHGNGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA8</accession>
    <name>A0A7W7WUA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ-like protein</fullName>
            <ecNumber evidence="3">3.1.13.3</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.3" evidence="3"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008946">
        <property type="term" value="F:oligonucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="231"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="34175" checksum="452B9F82E6737A50" modified="2021-06-02" version="1">MSDLTLALAEAARVLREATDVTLLGHVNPDADALGSALALGLALHRRGVRVHVSFGAPETVPESLADLDSEGLLVPASEVPARPEVLVALDAGSVGRLGPLADRVATAGQVVVLDHHLSNPGYGTVNVVDPTAEATAVVVLRLLDELRVPVDAAIARCVYAGLVTDTRSFRHATAATHRIAARLIEAGVEPEAVSRPLMDSHPFGYLGMLSRVLGRAVLDSAAAGGRGLAYAVVTLSDAAGLRPEEVESVVDLVRTVAEAEVAAVAKELTPGVWTVSLRAVSEVDVREVAQLLGGGGHRLAAGFTATGDADAVMASLRSALDAVAGRQHTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUS1</accession>
    <name>A0A7W7WUS1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001501</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="113"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="28948" checksum="2CE1D6C8A06BC592" modified="2021-06-02" version="1">MTTGLDQDDLRRVIRTALDEDLRYGVDATTEATVPVDAVSVAELTPRAHGVLAGIPVALEVFRQVVDVEVVESKRDGDKAVPGEPALVVRGPVRGLLTAERTALNLLCHLSGVATSTAAWVDAIVGTGAAVRDSRKTLPGLRLLEKYAVRCGGGVNHRLGLGDAVLIKDNHVQAAGSVTAALAAVRAHAPHLPCEVEVDSLDQLDEAVAAGAELVLLDNFTAAECAEAVRRAHGVRLEASGGLTLDVARVYAETGVDYLAVGGLTHSAPALDLGMDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV0</accession>
    <name>A0A7W7WUV0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20445" checksum="31479927A8832B39" modified="2021-06-02" version="1">MVEEAAIRAGTGEQGELFPDSSLPDELVGYRGPAACQIAGITYRQLDYWARTGLVNPTIRSAHGSGSQRLYSFKDLLVLKVVKRLLDTGVSLQNIRVAVDHLRQRGVQDLARITLFSDGTTVYECTSPEEVVDLLQGGQGVFGIAVSGAMREISGSIHEFPAERADGVVVDQPSDDELSRRRRTRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV8</accession>
    <name>A0A7W7WUV8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011966">
        <property type="entry name" value="PaaN-DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02278">
        <property type="entry name" value="PaaN-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="7">
        <location>
            <begin position="544"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="673" mass="70903" checksum="D0572EC3BF2A3DAA" modified="2021-06-02" version="1">MALLRSYVSGRWFTSPSEGAPLHDAVTGDEIARISADGVDRAAALDYGRRVGGAALRELTFHQRGALLKALASYLREHREELYALSARTGATKADSLIDVDGGIGVLFTYSGKAKRELPNSRVYVDGAVEPLGRAGTFVGRHIGTPLRGVAVQINAFNFPVWGPLEKFAPAFVAGVPSLIKPASQTAYVTEKLVELIIASGLLPEGSVQLLSGGAGDLLDHLTEQDLVGFTGSASTAAKLRTHPAVVRNGVRFNAEADSLNCSILGPDAVPGTPEFDLYVKQLVTEMTTKAGQKCTAIRRALVPAGLLDDVAEAASARLARVVIGNPADGTVRMGALAGLEQREEVRRSLKALLSTGKIVFGSPDKVEVVGADAVRGAFLSPVLLTADASAAEPHSVEAFGPVATLVPYKDVSDAVALAARGAGSLVGSVVTHDVDFAREVVLGVAPWHGRVLVLDRDDAGESTGHGSPLPMLVHGGPGRAGGGEELGGVRAVLHHLQRTAVQASPRVLTAVTDQWVTGTPRTEGDVHPFRKRLGELRLGDSVVAGPRVVTLGDVEHFAEFTGDTFYAHMDEEAAAANPFFGGRVAHGYLVVSFAAGLFVSPEPGPVLANYGLDNLRFLTPTFPGDELTVTLTVKQITPREDKEYGEVRWDADLVNQKGESVAKYDVLTLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV9</accession>
    <name>A0A7W7WUV9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="34" mass="3783" checksum="0475E4E01195A339" modified="2021-06-02" version="1">MDNGAVADFFVLRPARRFLAEALEIGGHLVERPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV02</accession>
    <name>A0A7W7WV02_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012804">
        <property type="entry name" value="Cob_chelat_sub_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02442">
        <property type="entry name" value="Cob-chelat-sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="6">
        <location>
            <begin position="472"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="653" mass="68510" checksum="792C512FF124CDD0" modified="2021-06-02" version="1">MGARFPFSAVVGHDDLRTALLLNAVHPGIGGVLVRGEKGTAKSTVVRALAALLPELDVVADCRFGCAPEVDAECPDGPHGDASAHRRPARLVELPVGATEDRVIGSLDLERALTEGVRAFQPGLLAAAHRGVLYVDEVNLLHDHLVDLLLDAAAMGRAHVEREGVSVSHAASFLLVGTMNPEEGELRPQLLDRFGLTVSVRASRDVAVRTEVVRRRLAYEADPVGFAARWQDDDADLARRIVDARARLASVVLPDAELRRIAAVCAAFEVDGMRADLVVARTAVAHAAWRGAEEVAEEDVAAAVRLALPHRRRRDPFDEPGLEEEQLEDALRQGAEHAAQDPDDDPDGPDDGPQGGSDGPDGESGGGAGESRDAPGKSTSDGRTHTPAPAFRARLLQVPGVGEGAPGRRSRARSAAGRAVRPSTVDGSGVHLIGTLQSAAPHQNARGRSGPGLVLHASDLRRAIREGREGNLVLFVVDASGSMASRQRMSAVTGAVISLLRDAYQRRDKVGVITFRGAAADLALPPTNSVDAAAARLRSLRTGGRTPLADGLLRAKKVLDTERVRDPRRRPLLVLLTDGRATASGVGGDPVDAALRAASLLVGTAAVVVDCESGFVRLGLAGRVAATLDAACLRLEELSADQVAGVVRAARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV23</accession>
    <name>A0A7W7WV23_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophanase</fullName>
            <ecNumber evidence="6">4.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002223</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-eliminating lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.1" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009034">
        <property type="term" value="F:tryptophanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011166">
        <property type="entry name" value="Beta-eliminating_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001386">
        <property type="entry name" value="Trpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="45"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611166-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="455" mass="49669" checksum="9EF2D5DD2FDCA1F2" modified="2021-06-02" version="1">MPTFEPYRIKVVEPIPITTRERRERALEEAGYNPFNLDADVVTIDLLSDSGTGALSAEQQAAGLRGDETYAGARSFHRFRDVVADLTGFPHIYPVHQGRAAERVLFGTLLKPGQTVLSNTHFDTTRANVELRGCTAKDLPCAAYRDLDSDAPFKGDIDLEALEAELSGPDDVALVLMTITNNGGGGQPVSMANLRAAAEISRRHGVPFFLDAARFAENAWLVTQREPGYENHTPRQVAEEAFRIADGAVVSLKKDAIVHIGGLLALRDPELAKRCELLVIAGEGFRTYGGLSGRDLEMIAQGLLEVTEPEYLRARAEQTAYLADLAAEAGVDSVRPTGVHALYLNAGRLLPHLPPSRFPGFALATQLYLEGGIRCAELGSLYLGELDEAGGLVKPAPYELVRLAIPRRVYTQSHLEYVGEILAAIAKNPERVRGYRLTEIPPLLRHFNCRLAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVG3</accession>
    <name>A0A7W7WVG3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030626747" evidence="2">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20649" checksum="27F0859B9A05EF4A" modified="2021-06-02" version="1">MNSKLGAATLAAVSIMMLSACSKSTTEGTPAAASHRPAVHTSSPSGDQQPSDNDLDITKYTDKPCDLIKPDQLATLGNLKPAKQGSGPLGPTCTWSAQDPTRDNTYTLSLATKGSTLESMIENVKMDPVFKTTTVGGREAYSTDSTDGTLKCGTGVKTSSKDAIFTQVRLGDEDTEKTGKSCQASERLAAIIIGNLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVG6</accession>
    <name>A0A7W7WVG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="7691" checksum="580323120146D95E" modified="2021-06-02" version="1">MAHSIVVNRVLKPVREAAGELIGEAIADAAGATGRRRERIVTTTRRVVNVGGALATSVAMADAVGASDALDSFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVG9</accession>
    <name>A0A7W7WVG9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hercynine oxygenase</fullName>
            <ecNumber evidence="1">1.14.99.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtB</name>
        <name evidence="4" type="ORF">F4559_002266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-L-cysteine + hercynine + O2 = gamma-L-glutamyl-hercynylcysteine S-oxide + H2O</text>
            <dbReference type="Rhea" id="RHEA:42672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="EC" id="1.14.99.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EgtB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.50" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044875">
        <property type="term" value="F:gamma-glutamyl hercynylcysteine sulfoxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02035">
        <property type="entry name" value="EgtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017806">
        <property type="entry name" value="EgtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032890">
        <property type="entry name" value="EgtB_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03440">
        <property type="entry name" value="egtB_TIGR03440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB_2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="171"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Gamma-glutamylcysteine binding" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>gamma-L-glutamyl-L-cysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="48999" checksum="61230FACAA562773" modified="2021-06-02" version="1">MTGIERLRDEVAAHLVRARERTTLLTGSVDDHDLVRQHSKLMSPLVWDLAHIGNQEELWLVRDVGGREPVRSDIDELYDAFKHARANRPELPLLGPAEARGYVGEVRDKVFDVLETSPLEGSRLVDGGFAFGMIVQHEQQHDETMLATHQLRVGPAVLDAPPPPRGAPVGPAEVLVPAGPFTMGTSTEAWALDNERPAHQAHTDAFFIDTTPVTNARYAEFVEDGGYADRRWWSEAGWAHVVKTPLVAPRFWERDGDRWYRTAFGTTAPLDPDQPVVHVCYHEAEAFARWAGRRLPTEVEWEKAARFDPATGRSRRWPWGDEDPTEAHANLGQRHLSPAPVGAYPAGVSALGVHQLIGDVWEWTSTDFHGYGGFEVFPYAEYSQVFFGPDYKVLRGGSFGSDRSAVRSTFRNWDYPIRRQIFAGFRCARDASPEESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP6</accession>
    <name>A0A7W7WVP6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase/N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="19508" checksum="DB1C8165E656A125" modified="2021-06-02" version="1">MPYYTRPSEDGVVAHFRALAEAAPVPLIVYNVPYRTGRELSAQALLRVAALPGVVGFKHAVGGIDETTIGMFDGLPEDFSVLVGDDLFLGPMMALGAVGGILASAHVETAAFGELIDAWRDGQVTRGRQLGRRLAPVSRALFAEPNPAVIKGVLHARGRIPSARVRLPLMPATESATKAALATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW02</accession>
    <name>A0A7W7WW02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="42" mass="4823" checksum="1B1C9AD314E926EE" modified="2021-06-02" version="1">MPRRETVVPEDMKDVHERFRYSPGVKSGPFCSWPANWGGTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW37</accession>
    <name>A0A7W7WW37_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6934" checksum="D3A098A9C648C0CE" modified="2021-06-02" version="1">MIYQAGGDQLLLNPRRVGRGHRATFGIALDLTDEVTGNDDNAMTGPFPPGMSGMSGMMPGSPTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW97</accession>
    <name>A0A7W7WW97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Imidazolonepropionase-like amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9462" checksum="2B361E1D96798DC7" modified="2021-06-02" version="1">MVEAGREKPGARPGRRRRGSPGGVEPLQQANNYIRRHRIAEAITAAHPYGRRIAAVTDVPFLPGGSSRVEWPECPTAITARIGPRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL0</accession>
    <name>A0A7W7WWL0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="22785" checksum="8CB851ABC5E6E906" modified="2021-06-02" version="1">MASTRDVGDKLRQVVDKADEILAALLVAGDLAGEAATTIEIAGAGSGEADVVIASATFREVEHDASRTLTHAVDDAVRAVNRIIDTLGTTAPALPGPGEGTSVSSARPSEEQRVEALRGELPPSVERLTGAKTHGRWFKRRGTFYVTTHVEMKVAARMRTKGIRHATLIANNTPCDNIWGCENLVGIVLPAGSSLTVFGPNGYERTFTGGKKPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL4</accession>
    <name>A0A7W7WWL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelamide amidase</fullName>
            <ecNumber evidence="2">3.5.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.86" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050537">
        <property type="term" value="F:mandelamide amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="432" mass="44481" checksum="87427EB03A438FC2" modified="2021-06-02" version="1">MAFTLSDWSDLDPVDRAHRRAEALDRARASTHGDWTALADGADTGAPDTGPLAGIPFSVKDNIDVEGFATTGGSALLDPAPAAVDATVVSLLRAAGAVVVGKANLHELAFGITSDNHHTGAVRNPVDPTRSAGGSSGGSAASVALGVVPFSLGTDTGGSVTIPSSFCGIAGFRPSTGRYPGDGVANLSTSRDTIGLHARTVADLRAIDRVITCDLPVRAGLAGLRVGLPTSRFVDLDPEVDRVVRAVLSALEGAGAVPVEVDLGDDLEIASGPGNDLVFHEAPRLLARRTDVPFEHWPEHIASPDVRTTFERLRDTPTTVSAYYEARAARQRLRRAYSDVFSRVDVVFGPTSPVPAPPLGQNSTITHNGHSVPAFGTVTRTIGPGTVAGLPMLTVPAGTTAAGLPVGVCLEAGAFHDPFLLAVGAALEDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP6</accession>
    <name>A0A7W7WWP6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lysine 5,6-aminomutase alpha subunit</fullName>
            <ecNumber evidence="2">5.4.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047702">
        <property type="term" value="F:beta-lysine 5,6-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="1">
        <location>
            <begin position="4"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="521" mass="55592" checksum="175F243EEDFD793D" modified="2021-06-02" version="1">MALLDLDPGVVATARRLAARAAAPVVALARGHTTVAVERATLRLAGITGADTGHPAGDVPWVNRVVDTVRAHCGLEHGVVLPVFHALRTHGLATLTDLAEATAAGQIRYTLPKGAERTRAARAATTAVNRGLRAIDRNRATRDRLVARLGDPPCRPWLYLIVATGDIDEDVVQAANAARAGADVIAVIRSTGQSLLDYVPEGATHHGFAGTYATQENFRIMRAALDDVSKEVGRYVRLTNYASGLCMPEIAVLGGLERLDMMLNDSMYGILFRDINPVRTFVDQRFSRQVHARAGIVINTGEDNYLTTADAVDAAHTVTVSQLLNEHFAQEAGLPDPLLGLGHAFEIDPKVPDSFRLELAHALLARELFPDAPLKWMPPTRHMTGNVFQGQLLDGFFNLAGVLTGQSILLVGMMTEAVATPFLSDRDLALANVRYVLDAAGGLAEDFRPAPDGLIVKRAHQVLGEAVDLLGRIVDDGLLAAIADGTFGLMRRPPDGGKGADGVIAKADDYLNPAAAALEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ1</accession>
    <name>A0A7W7WWQ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HAF family extracellular repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030508561" evidence="1">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="379" mass="38582" checksum="8A87138877A1F624" modified="2021-06-02" version="1">MHLVRTITLATAVALAVPVVVATGASASVRITELPSLPGFTSSSVVGVNDAGQIIGTSYPSGGVSHAALWTGGRVVDLGTGNGRAISRNGKAVLTDLVRINGPYEHALRVWDAGVTTDISPSSVGFIAAPAINGGGSIPVAYSSSPFGYHLERAAVYRDGALRGLSLPASGPHLSLRGINDGGQVIGSWQAMFGNDRFVFRCEKDGVCARLPHPTGGTGESASALNESGVVVGNGRNADGQLALRWDGNGVTALPGGVAGVASGDQAVNERGDIVGWVRAGGTQKAALWRDGALVDLSRPGDDQSTAIAVNDRGQVIGTRSGGGRTRPFLWQNGVFTDLPDLGGASATPIALNNTGTVIGSAQDAGGRYVAVSWSVRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWS1</accession>
    <name>A0A7W7WWS1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="101"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="40731" checksum="537D0094213A9B73" modified="2021-06-02" version="1">MRIVIAGAGIAGLTLAHRLVGHDVVVVDRSPAPRDQGYLIDFFGPGYDAAERLGILPVLRARSHVIDEAGYVDAEGRRVAGIGFGRLSAILGGRLLSILRPDVERTLREALPSGVDLRYGAAVVDVDNRADGVTVRLSDDTVLHADLLVGADGVHSTVRRLVFGDGHVRHLGFHTAAFSFTDPDVHARVAGRFRVTDTVDRLFGCYGLGRDRVTAFTVHRTPSTERPADPRAELRSVFASAGWVVPRALELCPADPYYDHVAQVVVPRWSRDRVVLVGDAAGAVSLIAGQGASLAMGGAYLLADHLDDPPGFERAWRPVVDEKQLVGRSGARWFLPSSPTRLWARRQALRLSRLPMVDRAVAHGMVGRPVSLETPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD7</accession>
    <name>A0A7W7WXD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase PrpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="29828" checksum="460947E58F90198A" modified="2021-06-02" version="1">MTVLDHRAPSTGWATARNARRYRADAAAVRTSPHAFAAAVADGIGDTPRAAEAARRFAEVALDAAWLHGPTAGIMAARRAASSPHPDEPALTALAPARHAEPGPHRATTPGHDGPPLRLHRPAPHLRPVPNRPAASPDDRPPGNAVLVVATGDHRGWSVAWAGDARAYLVTDGDAIPLTTDHTVGRYFRDRGADPGPRLDHVVTSTVRSGAIGTTHGRSTGRLVLVTDGVHRVLDAATLGRVTRAVADPADAAGALLDAARAAGTTDDCAAVVLDLSRPAARAALHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF2</accession>
    <name>A0A7W7WXF2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31061" checksum="92442E947673BDD4" modified="2021-06-02" version="1">MYHDLQINRLRALVTVVDVGGFRRAAEVLHVTQPAVSQQIRQLGSLVKGPIFLSTGRELKLSAQGEELLGYARRIVALNDEAVDRFVPQSGKVRLAIGIGDQLAEALPEILALLAKGMPHAQVSVRTGLSESLESQVAAGRLDLALLLQPRPQLTAGTSHELGRLRMDWFGRPVHSDGAALPLTLFTEPCSLRGRIVDAFNASDMPWRVGYEGAELIGLRAAAKAGLGVACLVANGDELWGLPRTERELPEPPGPVPVTMAISPGAASPGFTRVAKRALQNALHGYPFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK0</accession>
    <name>A0A7W7WXK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031054058" evidence="1">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21479" checksum="3125A577729E6CA9" modified="2021-06-02" version="1">MLTTATAALLALSALVPTQDVPDAPPLRVEVASINGSGCPAGTAEVTTTDRTFSVSYQAFYAQAGGGANPVEFRRNCQLSLRVSLPDDYTYGLARTSYDGFAHIQDGATALNRVSFYFQGGPTTTAINRSFPGPFTDEWRTAYRPDPADVVYSPCGGTRNLNINAELRIDIGTADREKPNFVLTEASRGGLRAEFTTKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX5</accession>
    <name>A0A7W7WXX5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030982436" evidence="2">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="37"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29577" checksum="21095A1799653053" modified="2021-06-02" version="1">MALASLRALACVAVLVLASCSSGDDTTVVGRAGRDNKLTIGVAFDQPGLGVRRMDGVLKGFDIDVARYVATELGVEESGITWVEVSPPERENMITSGRVDFVVTGYSITPKRKEVIDFVGPYFIAGQDLLVRMDDTRVTGPESLAQDGVRLCSTQGSTSAQHVIDEYAPGGRLVEYPQFSDCVTALLAENVDALTTDDVILAGYAAQNPEVLRVVGKPFSKEEYGIGLRKGDTASKTKITEAVRKMMTSGEWRKSLEANIGRSGYKIPEPPELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ4</accession>
    <name>A0A7W7WXZ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phytoene dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="52920" checksum="A3E35876B8736941" modified="2021-06-02" version="1">MDSDYDVVVVGGGHNGLVAAAYLARAGHSVLVLEKLGHVGGAAVGEHAFAGVPARLSRYSYLVSLLPDRIVADLGLRIALRSRAVSSYTPEGDLLVERTPGERTRASFRALTGSDAEFSAWCDFYDDVAKFAAVVAPTLLEPVPTRAELRSRVDRRVWERLVDRPLGETIEETFAHDVVRGVVATDGLIGTHASAHDPRANRCFLYHLVGNGTGEWRVPVGGMGAVTAELARVAREAGAEVVTGAEVSTVDADGRVAEVGFGGRRVGARFVLSGVAPGTLDALRGRTPRPVAEGCQVKLNMVLERLPRLKSGVDPREAFAGTLHLDESYSRLETAYRESASGALPEVLPAEMYCHTLTDPSILAPGLVERGWHTLTLFGLHTPASLFAGGGHEDLAARYLAGLDRVLAEPVADCLARDRDGRPCVEVRTPSDLEAELGLPRGNIFHGDLDWPFGDDGRWGVETDVANLFVCGSGARRGGGVSGIGGHNAAMAVLEAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY52</accession>
    <name>A0A7W7WY52_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25548" checksum="7858FAC5FD4430A5" modified="2021-06-02" version="1">MPADQPTIVATSGGYIAGRRTEIEFGALVHHAVELSGARRPRVCHVGTASGDQRSWQANVDEAARVAGWDLAHLNLFPMPQVLDVAEFVLSHDVVWVGGGSVANLLAVWTVHGLGPVLRTAWERGVVLGGVSAGSICWYLGGSTDSFGPELRVVTNGLGFLPYGSGVHFDSEAARRPVVHEAVRDGVLPETHCTDDGAGLVYFGTRLVEAVSERSRGGAYVVVRDSSGNPQEESLDIRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYC3</accession>
    <name>A0A7W7WYC3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Coproporphyrinogen III oxidase</fullName>
            <ecNumber evidence="6 12">1.3.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_004922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>coproporphyrinogen III + 3 O2 = coproporphyrin III + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:43436"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="1.3.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:43437"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.15" evidence="6 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0274">FAD</keyword>
    <keyword evidence="8 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="13">
        <location>
            <begin position="10"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4967563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="468" mass="48254" checksum="FD702F38C5E1A2B0" modified="2021-06-02" version="1">MRVAVVGGGISGLAAAHRLRLLLGPAAEITVVERSDRLGGKLRTEQVAGLRYDVGAEAFLHRRTEAAELVVELGLGGHVVHPTGAPSTIRAAGAIRPIPAHTLMGVPASVEAVRAVLSAEGLRRVAAEPDLPPIDLAGRDVAVGALLRERFGPEVADRLVGPLLGGVYAGRTDVLGLRATMPSLATALDSGVGSLLAAAATTMPAPPQPRVPRPPVFGTLDVGLSALVDALSTRARIRLGLPVRRLVRRERDWRLEIGSATAPEFLDVDGVVLAVPAPAARKLLADIAPKASVRLGEVELASMAVVALALPPGTELPERSGVLLAEGERYADGTPFSAKAFTFSSRKWAHLAGGPALVRGSVGRHGDVRVLQRDDEDLVAAVRADLAELTGITAAPIDVLVTRWGGGLPQYGVGHLDLVRDVEDAVEDVPGLALAGATLHGVGIPACIATGDAAAARVAAHVLGRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH0</accession>
    <name>A0A7W7WYH0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20975" checksum="AECD84ECC98A544A" modified="2021-06-02" version="1">MTAAPSQRLVELSPSDLNARLGEALALYVSAMAYPPGTAEQRAPMWMAHMLRDGWRCVGAFDEEDALVGIGYGYRGSVGQWWHEQVRHGLTAVAGPVAVERWMHDYFELTELHVLPRAQGRGTGERLLRTLLDGVATDKVLLSTPEGPSKAWRLYRRVGFVDVLRNYQFTGDPRPFAVLGRGLPMEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ7</accession>
    <name>A0A7W7WYQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28319" checksum="07F7F1EE75A3A002" modified="2021-06-02" version="1">MTTMISSPAGRVHVRATGRADGPVVVLSSGLGGAWFDWDATAALLAPHARVLVFDRPGTGGSGPALAPASLEREVAVLDAVLADVPEAVLVGHSMATLHVEAWTRLRPDRVRGLVLVEPDPEVPGAGRPFDVSAVVARWLLRLGAQRFIARHGVRLRRRAVASSTLGRRDPAPAELVREVYGRPTLAGAVLDELASYPDQVASVDRLRPARPLPEVPFTVLSAGRVPTAHRLLAGLVPWGEAVAVPGSRHLMPVDRPDAVASAVSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU0</accession>
    <name>A0A7W7WYU0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2786 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="42550" checksum="191EF5ED9A3722B4" modified="2021-06-02" version="1">MDPLSQALRHAAATRKARPPRAGDLPATEVEDAVHGVLADALHDLWDHGWLPYDVHEVVRRDEDERARSLLVDAVARDVAGQALHPVWRGQVADIGADVWWDADRPHVDQWASRHIETLDDALAATVAILRVLRALPVLPVIVPKPGSPLVGLDHRGVDPRVLNRVRGLLAKAESTPYPDEAEALSAKAQELVTRHALERMPTEEPTTVSRRLWLDKRYFDGKAHIVHVVAEANRSRAVVYRNPGFVALVGEELDLEIVELMSASLLVQATRAMVAAGDGARKGDEERSGDFRKAFLLSYAHRVGERLRAATATDDDRLLPVLAARKTAVDTLYRTLFTRTVSRSTPIRSEAGWSAGRSAADRADLDRPSASTPRRVGRGRRRTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX1</accession>
    <name>A0A7W7WYX1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12205" checksum="4132C698F2E52BDB" modified="2021-06-02" version="1">MAQKVTVTLVDDLDGGKAEETVGFGLDGVSYEIDLSAGNAGRLRDALADFVAGARKAGGRKRGPGRPAGVKAARPASADREQNQAIREWARKQGMKVSDRGRIPAEVLESYHQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX9</accession>
    <name>A0A7W7WYX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18444" checksum="BC7AAA395AD08CB2" modified="2021-06-02" version="1">MFLETPRLVLRAIEPSDVDDVARLLAEPDVMRYIDTGRPVPRDEVEREVMPKVVGGVGWWAGIEKSSGAFVGWFELSPVAEGVRELGYRLHPSSWGRGYATEGATALVAKGFADLGVHRVVATAMAVNTGSRRVLEKAGLVYVRTFHEDWPDPIPGAEHGDVEYALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ17</accession>
    <name>A0A7W7WZ17_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18446" checksum="BA59C4637548689D" modified="2021-06-02" version="1">MFEYLVLGDVTLVIETPGNEFSVVTDSRIGRSARRERDFADALPYGSSEKANALVAMKRAELECRNREGGYWIAGSDPSAAEHALVGRFGASSVGRFALLTDGAARAVDLFGMFDWSHAFKLLADRGAHGLIGAVRHVESSDPAVLRWPRNKVSDDASVVYAELRPCMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ32</accession>
    <name>A0A7W7WZ32_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7325" checksum="5AD5F5BF497CE24F" modified="2021-06-02" version="1">MKRDPELLSATWRKSSRSQNGSANCVELAKLINATAIRDSKNPDGPVLRFNSAAVERFIAVQHDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SX89</accession>
    <name>A0A7W7SX89_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD</name>
        <name evidence="4" type="ORF">F4559_000021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="149"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="235"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31219" checksum="4189AEADD1BE42B5" modified="2021-06-02" version="1">METAWFEGLTAARIATVEALLAAAKEADGVAAVGEAVHLRLRPGATGSRHLLAERDGVLVGYLHLDVVGDADGNKVAELAVHPEHRRRGVGTALVEAVLAERPRIWAHGGHPGAEALAAKLGFRKVRELLKLRRDLAGELPEARLPEGVTLRAFVPGRDEEAVVRVNAKAFSWHPEQGAMTEDDVRLKEAEPWFDAAGFLLAVDGDDRLLGFHWTKTHGARRGEVYVVGVDPDAQGGGLGKALTLAGLAHLRATGRDEVVLYVESDNAAALSVYTRLGFTRWDSDAQYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXN7</accession>
    <name>A0A7W7SXN7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030677088" evidence="2">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15210" checksum="0B1DE74C22271010" modified="2021-06-02" version="1">MTESAKRRNWLLMAGAAVLVVTGLAAVASTSAPEEPSVVVYEVTGEAKSAVVVYSTFTEAGTAREELTSFPWRKELTVHDEVRDGVLSVQMGAGGGSVACEVGVDGVERRSATATGPFTSALCDGFHGDDFFRGTWYPGGELRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXT1</accession>
    <name>A0A7W7SXT1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10367" checksum="4F26FC465FA5AF9C" modified="2021-06-02" version="1">MAGFGVGPGELQNVAKQYQDHGADIIQMKSGVTPAVGAGQVGRKFRGVETKYRSYFDRLGASMETFGTEANNVAQRLNDVAKSYESNESATSGQFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXW1</accession>
    <name>A0A7W7SXW1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin-dependent carboxylase-like uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="29358" checksum="EBE21F898DB76A30" modified="2021-06-02" version="1">MSRTLTVLATGPQALVQDRGRPGHAHLGVPPSGALDPVSLGLANRLVGNDGDAAGIEVLIGGLAVRASASCTAAVTGPYAPVRRNGRDVDSPVHLAPGDELAIGRAEHGLRVYLAVSGGVDVRPVLGSRAADLLSGLGPGPLAVGDVLPLGAARGVPVGADVLVPVRIPPELVVPVLLGPRHEWFDNPAAQLDKGNWAVSEKSNRVGLRLEGTSLVRTESTRYSELPSEGLVTGAVQVPADGRPVVFLADHPTTGGYPVIGVVAPQVLHQLGQARPGTRVRFRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXZ2</accession>
    <name>A0A7W7SXZ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23411" checksum="31D909E062462C3F" modified="2021-06-02" version="1">MTVRVFLVDDHALFRAGVRAELDSITDEIDVVGEAGSVGEAVAGIGHHRPDVVLLDVHMPDGGGAEVLRQVRTALPEVVFLALSVSDAAEDVIAVIRAGARGYVTKTISSQELVRAVVRVAEGDAVFSPRLAGFVLDAFADRPGAAPISDPELDLLTPRERDVLRLLARGYAYKEIASELFISVKTVETHVSSVLRKTQLSNRYELSRWASDRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYB6</accession>
    <name>A0A7W7SYB6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type VII secretion protein EccB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_000280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4962921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="542" mass="57211" checksum="220FA6068758FA47" modified="2021-06-02" version="1">MASTPTTKSQVQAYRFVLRRMQSALVRRDAVMLHDPMRTHSRATAVGVILGVIGLIGFLVFGFFSPDPRLDDETQIAISKETGQVYVVRKNPTQLIPMTNLASARLLLLAQANPDKAQAAGGGDAPAGQLGAAPGVQGGDPKLVSEKALAKLPKGRLTGIPDGPDMLPTKVEDRIGAEWSVCDTLDLDESLNDQATGKFQTTVFAGVGAGGSPLDGNKALLVRANTDDKQAYLIYKAPVDSKITSTSTVRAKVDLSKNEVVTALNLRGKKVRAISSGVLNAIPEARPLVAPTIDGRGAAATYITGVNLKVGDVIEVARTGSDSVFYVVLKDGLQEISRASGDLIRAAYAQGAEPKKVDIARIPDKKPAERLDLLDYPSEVPDVLDPNQNNRVVCLGWRAENPQADNRSQHTQVTIAPSLPMPSGAMAVDVNQVGATGEVVGQFVMAPGKAAVVRSSTSTQDFRSGPIHLITGRGVKYGVPDTLTAGALGLGTEFVPGPESILRLLPNGPQLNRNDASRSWDSIPVPKNAGLLPEQQQAKQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG5</accession>
    <name>A0A7W7SYG5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28745" checksum="0558277F660FDAF3" modified="2021-06-02" version="1">MQNSPKWVAARDELERPNAARLYDYYLGGAHNFAVDREFAAGSPALIPTAEMIQHSRAFLRRAVRACVANGIRQFLDLGSGIPTAGNVHEVAHQDDPTCRVVYVDNDCATVAHGRTMLRDVANVAFAEADIRDAKAVLTSAEVTSLLDLSQPVAVLMVAILPYVFDDDSPVDVVAAYRDGIVPGSHLVLSHLTADNRPELVEELVRVSTQRMARITARSKAEVEPLLEGFDLLEPGLVLVSTWRGDGVPETDAETVSYGAVGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG8</accession>
    <name>A0A7W7SYG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="17739" checksum="B9D56550C7EB76E1" modified="2021-06-02" version="1">MHPQRDPDRRARLQAVAGEALAAAKVGEDAVAVDLVTGYLSGSPEGNEEIRELVLLLFSECSDMVSHLGSGGSTPVKMQVFDEDGQEVPIDDADPPVRTAIRTLLAEVHGDQEAAAEQIEIALANGRPQELATVVLQALRWTVKLATECSTRDLAVAGWIEAALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZW2</accession>
    <name>A0A7W7SZW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="124"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="45561" checksum="074B2E966EEE7B2C" modified="2021-06-02" version="1">MSFVAAVTIWSGLHRRSFLRWFWLRVVTEWRRATVYVPRWRSVVRLSGLVGRDRGREYRPRLRRVRSEGWRDRVRVRMVPGQAPEAWEARREGLAHSFGARSCRVRVLRPRVVELDLVHSDPLARPVVVPPLGGVEVDFRRVVVGVTESGRPWRLRLLGAQVLVVGVPGAGKGSVLWSLVWFLAPAVRAGLVRLVGIDPKGGMELGQCPEAFDRVVYDNGPDAVALLEAVAAQVRERASRYRGVRRLWTRSAGEPFTVLVVDELADLVAYQPDKGLRERAVRAVQTITSQGRAPGYAVVGLVQDPRKEVVGFRHLFSTRVALRLDEPGQVDMVLGDGVRERGAAAHEIGEDTPGVAWVKQDDRREPERARAFHVTDGDLVELRDYLTYGRVHEQPDDGDQWQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZW3</accession>
    <name>A0A7W7SZW3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="9005" checksum="A3ED8F0A140FAA77" modified="2021-06-02" version="1">MSDPSRYDPVDLWDRMLAAKQVVEEFEAGVDPGEQVAAFLYDLKLALNGDVLRDEITGELMRFRPGHGQALTALLAAGREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY0</accession>
    <name>A0A7W7SZY0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12362" checksum="2FAB0780F64FD7DA" modified="2021-06-02" version="1">MTTDPLAYFEDETLPDHWSNGDLAAEITRNDPVADARVVWILAARVATAGAANTDPLHTLHDLGRAVAAITVTADAIIRDRFDDLDAEETTDFRSTIDHLVAAAKGLDDLSGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T037</accession>
    <name>A0A7W7T037_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001492</name>
        <name evidence="4" type="ORF">F4559_003917</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11844" checksum="D75CD74FCE893325" modified="2021-06-02" version="1">MAADKAYSSKANRAYLRRRRITAVIPEKADQQANRKNKGSAGGRPVSFDPVRYTRRNTVERCFQKIKTWRGLATRYDKSPENYEAGLHLRAAIMWLKTLTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E1</accession>
    <name>A0A7W7T0E1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (TIGR02453 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="24487" checksum="FE1DC05D830939A2" modified="2021-06-02" version="1">MEFTGFGEYAVDFFDGLVGDNSKAYWDDHKQVYLSDVRAPMEALLAVLEPEFGRGKVFRPYRDVRFSRDKTPYKDHCGGVVELGRGGGAHYVQLGTEGLFVAGGSFAMASDQLSRYRESVADDVRGGVLRTLIADLVGRGWELRGDVLKRAPRGFPPDHPRIDLLKYRRIYLARTWPPDDLLHEPGCLDRVRSAWRELNPLVEWCADHIGLTGIGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0I5</accession>
    <name>A0A7W7T0I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acyl-D-amino-acid deacylase</fullName>
            <ecNumber evidence="2">3.5.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.81" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047420">
        <property type="term" value="F:N-acyl-D-amino-acid deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023100">
        <property type="entry name" value="D-aminoacylase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="41"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="529" mass="56715" checksum="9932FEFCA5E3BD41" modified="2021-06-02" version="1">MDIVFNGALVVDGTGATGRRADVGVHDGRIADIGPRLSGRRTVDADGLVLAPGFIDMHSHSDLQLLAAPEHLAKVSQGVTTEVLGQDGLSYAPVDDAVLAALRAQLAGWNDDPAGFDWDWRSVGDYLDRLDRGIAVNAAYLVPQGTLRMLCVGWEDRPATPSELDRMREVLAASLHEGAVGLSSGLTYTPGMYAPHAELVELCRVTGRLGGFYSPHHRSYGAGALEAYAEMVEVSRSSGCPLHLAHATMNFEVNRGRAGELLTLLDDAIEAGADISLDTYPYLPGATYLSALLPSWASEGGPEATLARLSDVDTRELIRREIEETGSDGCHGVPVDWATIEINGVRRAENSHLVGHSVAASARAAGRPPADLYFEVLTSERLGTSCLMHVGHEENVRLIMKHPAHTGGSDGLLVGDRPHPRAWGTFPRYLARYVRELGVLGLEECVAHLTGRAARRLRLPDRGLVRTGYAADLVLFDPDTVADTATFEQPRQAATGIPYVLVNGVPVIDDGRRTDALPGHSLRNPGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U2</accession>
    <name>A0A7W7T0U2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="7103" checksum="E13E8F28BCCC8AA6" modified="2021-06-02" version="1">MTNRSTDRLPVSAWVLAIVVTIATKFLLRYLYPGMPWYISTLLSLVILNVVLGVAWLVLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U5</accession>
    <name>A0A7W7T0U5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="635" mass="68557" checksum="601A51C2F78FAC61" modified="2021-06-02" version="1">MGERGFDAQLLGHLVEVASDDQVHLVQRVAGGIDPGTVFGKHASSLAGLVTELPRVHAALFHHHRQGQPAIRLLNRLCANGVRLVRGVRDIWGADPTLDGLLAVLAEAIGEPPSRDLAGDLATRLQRHVDDLPALIATRFKRAWAGPAGPTLADSVADEVACLLAFADRDPTALEHDLTAAARAGKPLDADTVWRALLPDPAEHVVAGVVRGTAELRDLRLFHPGTDQRPLRAATGLRWGMSTGRLHKFVSGFAVAGEACVVTVTVTARDKPSAGRLARRTLAELLDQYLAGTRFAELELDPRVLVARVGTTSTLELGPPVRGTPQAKPLTTPHLPEEVRRSLRMAHIAARTDSPSAAAALSWSAVEACGLANRDELAAALSLQCLRQAVVQTHRNVRLSVVTRLAFARNRTELAALSARQARRAADACPPGPRREELRDALAHADKIHREVRDAHDDLRGKLDTTALEAAAPYRRRFHLDDLNTWVDVLTGPSPLDDLLPHLHPLAGRQAAVWRSRLASPRRCAAWLRRRQQRMTTVLDALYATRNLTLHAGVFQSAADTVHGAGAVLVTDLVLELLGHWYNTAPTARQPVSVVTALARRQAAVLAGFARGTPPAALDFESLTAPVPSAPWRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U6</accession>
    <name>A0A7W7T0U6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031500163" description="Germane domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="4">
        <location>
            <begin position="213"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="589" mass="61313" checksum="D698CE9024561AD0" modified="2021-06-02" version="1">MAARATRDRRSGGVIALLLALLSASGCAAIPTSTSPIPVNPSAGPATAAAVPEPSAELDPLSLVRGFVNASASPEGDYAAAKAYLTPDAAKTWDTKSPPTIVESTFNTVPGQSEDQPADGKRREVLLQGKNFGRLEADNSFAQQIGDFDIPVEVQQDDKGQWRISKPPSGVYMPLSGFNQNYRRVTLFFYTPDFGVLVPDPRYVVVPPSTSIPLRVVELLLKGPASAMRGALATAVPNGAVQRKDAQEADDGALEVDLTRVGDLTAQVRKQIVAQVVKSLAGVTSSRVRVLVEGAQISPEQNEWRPADIQSGDALITPDAGQSGLLVGGGQVRQLGNGAQVKGPAGAGDYRAVSAAQSLDGTELAVVGRLDDGSVRLRVGLTEGDLAAVDLPANTMTRPTWLYSGRVGEPATEVWTVVNGANVVRVNKGDGGWKANAVNASDVAFLGDITELRLSRDGTRVVAVVGGKLVLAAVVRGQDSSVALRAPRLLQVGVLGAAVQSADWLAQDVVVAGTSINAYPIAKVNIDGLRIERFNTSNLTAPVTSVAAAPGRNVVAVDQSGIWSAGDIGDVWRAGTITTALPSSVFYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T118</accession>
    <name>A0A7W7T118_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Shikimate kinase</fullName>
            <shortName evidence="10">SK</shortName>
            <ecNumber evidence="3 10">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroK</name>
        <name evidence="11" type="ORF">F4559_001947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="3 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="17721" checksum="346BB69F21927A7F" modified="2021-06-02" version="1">MSPRFVVLGPPGAGKTTVGQLLAERLALPFRDTDEDVVTRTGKPISDIFTTEGEPAFRALEEDAVADGLATHDGVLALGGGAVLSATTRERLQEHTVVFLNVGMAEGVRRTGLSTARPLLAGVNPRATFKTLLDARLPLYRQVATVEVLTDDLEPEQVVTAILAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T132</accession>
    <name>A0A7W7T132_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11561" checksum="4E84892694D1E668" modified="2021-06-02" version="1">MALPQLTEEQRAAALEKAAAARRARAELKERLKRGGTTLKDVLKAAEDDEVLGKMKVSALLEALPGVGKVRAQQIMERLEIAPSRRLRGLGERQRKALLTEFSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T139</accession>
    <name>A0A7W7T139_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">F4559_001466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="438" mass="45245" checksum="1BDBA0A7F3BAC08F" modified="2021-06-02" version="1">MTPPHNYLAVIKVVGIGGGGVNAVNRMIEVGLKGVEFIAVNTDAQALLMSDADVKLDIGRELTRGLGAGANPEVGHKAAEDHREEIEEVLKGADMVFVTAGEGGGTGTGGAPVVASIARKLGALTIGVVTRPFSFEGKRRAKQAEEGIQALRNECDTLIVIPNDRLLQLGDIGVSLMDAFRSADEVLLSGVQGITDLITTPGLINLDFADVKSVMSGAGSALMGIGSARGEGRAVQAAQKAINSPLLEASMEGAHGVLLSIAGGSDLGLFEINESASLVQEAAHPDANIIFGTVIDDSLGDEVRVTVIAAGFDSGGPTHKKLEPQALSSPPRGTPMVSGQAGHVNPNPAPPVEQAVPQRPIVPPQPQHSQPAQPQHQPQHAQGNGGYGTSSTVPQSVPQPVHRTLPTSLPTSGTLPSRAVPVTDDPDDEVDVPPFMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T194</accession>
    <name>A0A7W7T194_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="631" mass="68697" checksum="B91FD1220AE60BAD" modified="2021-06-02" version="1">MGEKAKLSRVDEDLAELARRHGVATRYQDADRRWVDVDADVVVAVLARLDVDAATPEAVGRALSAPPADEGPLVLRDDVVLDGPGTVELEHGGAVDLPAVLPPGYHRLAGRTVIVAPRTLPPVPAAWGWMLQLYAVRSAGSWGMGDYGDLAEFAARSAAELGAGVVLVNPVQAISPTFPVERSPYSPSSRRFANPLYLRIVDLPEFTRADGDTRDRVLALAPADDSALIDYDAVWRAKLAALELLWPFADRVEPTGDLLGYARFCALAREHGPDWRTWPTAQQDPETATPDHDRVLFHAWLHRACEAQLDAARRAARDAGMAVGIVHDLPVGVHPGGADTWAVRDAFAADVRVGAPPDAFTRLGQDWNLPPWRPDRLAEQDYEPFRAVLRGVLRHADGIRVDHVAGLWRLWWIPPGEPARRGTYVHYDSEAMLAVLALEAYRAGAVVVGEDLGTVEPEVTETLHRDGMLSSAVLWFMRDYDTPGHPLIPPGQWPVGAMASISTHDLPTVAGFLAAEHVRVRADLGLFEGDVQRELEAAGTERADLVALAEREGVDTDDLVTALHGVLARAPSSLLLTSPQDAVGDTRQPNLPGTVDEYPNWRIPLSVPLDRLLADDRVVRVARVLAARPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E0</accession>
    <name>A0A7W7T1E0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="163"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="669" mass="73783" checksum="86B96C6D7B31E276" modified="2021-06-02" version="1">MSDGELGYERAKIAGMYERLDREREEVEGGLAAVLRDAVGERWPREVAVRELTARRDRLKAADHGLCFGRIDHLDGGRTYIGRVGLFDERYEPLLVDWRAPVARPFYTATGVRREGISRRRHFRTRGRVVEGFHDDELAGDDTALLSALAAPRSATMRDIVATIRAEQDEVIRLDHRGVLVVEGGPGTGKTAVALHRVAYLLYTRRERLSRHGVLVVGPNVRFLRHIGDVLPSLGETDVVFATPGELFPGVRTTLEDVPEVRGLKGGLAAVDVISEAIRDRRELPDEPIPIPLSDVVVELSADLVEVAWARVGEVEHNAGRELFHAGLVDVLVPLAVAAIGEDWPELADDVRRELRGSVELGAAVDALWPLLTPQELLADLYEGRCVALGYPELYRADGWAWTVSDVPLLDEAAEQLGDDGSAGRAAARERARRVEYARGVLEVLDTDPALRRDTLRAVDLVDAEWLADRHEAPDHRVLAERAAADREWTYGHVVVDEAQELSEMDWRVLMRRCPNRSMTVVGDLHQREAEAGARDWGARFAPYVDDRWVHRTLTVNYRSTAEVMERAGAALAEIDPLAVPPRSVRHGAVPWEVTTADPDAVIAAARPDSGTFAVISVDGPLTPRAAKGLEFDTVVVVDPGRMTAVERYVALTRATRQLGIVHTAPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E4</accession>
    <name>A0A7W7T1E4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="14055" checksum="08A14C2E16E66B41" modified="2021-06-02" version="1">MREADGGGGKVDFIAETVTGGAAGSSLVGTQTKFSVDPAQARKLIDGLYAALDKLTKLAQEADRLRQTESPGKDLYSGFATLAIRKAAGTDPGGYAWANDQARKALKKTIENIEAALRQYEATERVAEHGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K9</accession>
    <name>A0A7W7T1K9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrS</name>
        <name evidence="13" type="ORF">F4559_002232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="251"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4964873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="682" mass="76059" checksum="722124F2FE095065" modified="2021-06-02" version="1">MSQPLPSAALVPPRVVVPAGTTAGTAVREAGLPGKGPDAIVVVRDAEGHLRDLSWTPAVDVEVEAVAADTEDGRSVIRHSTAHVLAQAVQQQFPDAKLGIGPPVRDGFYYDFKVDKPFTPEDLQALEKRMKAIVKGAQRFSRRVIESVDAAKAELAAEPFKLELVDIKSDVDTSEIMEVGGGELTIYDNLDPRSGDQVWGDLCRGPHVPTTKHIPAFKLTRVAAAYWRGNERNPQLQRIYGTAWESQEALDAHLELLAEAERRDHRRLGAELDLFSFPDEIGSGLAVFHPKGGIVRKAMEDHSRARHVEEGYEFVYSPHITKGNLFQTSGHLDWYRDGMYPAMHLDAEYDDEGKLRKPGQDYYLKPMNCPFHDLIFRSRGRSYRELPLRMFEFGTVYRYEKSGVIHGLTRVRGLTQDDAHVFCTEEQVEEELKSLLAFVLGLLRDYGLDDFYLELSTRNDEKYIGADDVWERATKTLEAAALSSGLTLVPDPGGAAFYGPKISVQAKDALGRTWQMSTIQLDFMLPEKFELEYTASDGTRKRPVMIHRALFGSVERFFGVLTEHYAGAFPAWLAPVQVVGIPIADEHLDHLFAVAAELRKHGVRVEVDASDDRMQKKIRNHTTQKVPFMLLAGGKDVESGAVSFRFRDGTQVNGVPVERAVATVVEWIARRENASPTADLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M3</accession>
    <name>A0A7W7T1M3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deazaflavin-dependent oxidoreductase (Nitroreductase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="3">
        <location>
            <begin position="149"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="29942" checksum="9B8B83BCB20409ED" modified="2021-06-02" version="1">MGEVLDFNKQVVDEFRAHRGVVGGFFEGARLILLTTTGARSGRAHTVPLGYLPDEDGILVIGSAGGTPRHPAWYHNLLASPEATVEDGTFTYRATAEVLTGAERDDVWARAVEADAGWAAYQEKTTRVLPVVRLRQAGFSPPGGSSFGEALKLVHDAFRRELATIRREVAASGPTLGAQLKINCLVACQGLRGHHDREEQAMFPALAERFPEAAPAIGLLRQEHEKVAALIESLQAAVRSPAADRKRVVSEVDGLVAELLAHLDHEEELVVPLLDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T223</accession>
    <name>A0A7W7T223_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26575" checksum="FBFFE06EE0F964EB" modified="2021-06-02" version="1">MVVVLGRPGVLVDGVVVHPARRRVRLLLGLLAVRADRALSSEWLIDALWPGRPPVSAAANVRSHLAELRRVLRAADPDGPGIVASGDGYVLVSGVDGVDVTRFRRLKSEGRTLRCAGAYGAAARCLTDAVDLWRGPVMSGVPVPDAVRADVTVLDEQRVDAWEELMDVRLALGAHQDLVPVLAGLVVEHPLRERLWCQLVTALCGAGRRSEAVAVYQRLVRVLDTELGVEPCPESRALYEAIRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T224</accession>
    <name>A0A7W7T224_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="139"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1657" mass="182144" checksum="1AA1A8394E5D26DF" modified="2021-06-02" version="1">MENRNDISGVVNGPAVQVGVNYGGVNYHVAAEAPRVDLPRPSGWADAPELPDDVRALLRAQISMAQTMPYKLPGARRPSLATVYVRQELGGVVEEPDQHRPAPALDHRGRLIEPPRRPVARTTVRPPSRAVREALDDHDHLIVTGGPGQGKSTLSLRLAADIAKHWATRAEPPLSEPVVPLRLPARLLAPRVGMPFADALAEAAGEEYGSLLPHRLDPRVLVEPVMGCRWLLLVDGLDEVADAGTRDRLVTVLAHRTTHRVVLTTRPIGGAALAPLHEIGAQRYELQPFDEAALTRFADNWFGHGERFVRQVREAHLDELVRVPLLATIAGIIFEQRADHPLPDNQYELYEAYLKYLRDRPLAPSRFDSIRDSLLEHLGCVRLEADTSLIAAARDRVGEEEGLGEYLTSVGPLTPRGDDVSFLHHSFAEHLAAKAKARILPPEFDPAHEDFVRLVHTARSEERGRHARMVLLHYCHLHLDQADGVVRWLHQGDDVQQLIAAQLLAWHVPVAQSTLEEFLATVRAWAATTSSTALKILAQASRAHHPGLVAWLTALASDAALPWASRIEAAAALAIRIREQGVSDAAEVLSTAAEDRSVSLRDRLSAAEALSQCGPDERAVALRSLRATLTAPGAEGTVLRDTALVLVGLGVEHRTEAVEALLVALEDPCAADEDKVAIATGLSEVSVEHQALCAEVFVVAMVSDGWQVSRNAAAALADQGSRRVGEAAELLSGRIADRALDTTARIRAAEALAAMGPQYRRPAGQALLKIANDTGHSAYDRVQAASLLSGLGVEFHVGVVRTLREVIAVRHLAPFYRRQAAEYLAELGPEYHTEAARAFEEQSRNPHQRLAVLESLAQLGGVHREVAVTTLRKYVADRDRPPRERVHAARVLVRLSTDHHDELGGHMVEVAAETDEVNSATWAWRVLEDLGLVHRDSPGDDLVTAIRHGGTRVRRIAMAGLRIADGERAAQALLTTLRIGLTDPRVRTVVDMEIVRTGRRYHDAVVVALSGLYRSGMLPFDYASRCALLLVDAGERPRARFLELVRCVVADPDVPDDDLLVALTGLKDSADPEDRPALEAIMMDGVLSRSIRIRAASALCEADRSLFTEAVALAAAFGRHMPHFDWAIDFHERGAGLVELLMPVVVDVDCRGVCRERATMVLSERHPEQRGRVSAFVQGRMLDDFLGVSERTKACAAATLDEEVAHCREVFDDGKAALKDRAEAASRLVELGEVDGDDAIAFLRRVAADRRSTMEERRAVLRRLEWLSPPMSVISALREALDNRPDEVAVEDRMVSLGRRVHWMDDGEALIRDVLDGAETDLAERVKAAVELARLRPALVQDAAESLWRLRPSPRAYRALAEFGRRRRHEVVAELIAMALDEGRRWQARREAALLVVEIMSEPDDAVVEFLNGRLDERSLSDRDRRRIARGLLRLDVLRGVRDSESARASARWRAAMDMYEYDVADRAAGAKVLRDIANDPLCRPALRWRAARGLATFGVRGQEWGSEALEALMGDETLSVRVRASAAQALGLARPDLRIKVRKFLWKLAIGTESAVRLHVLLARLEIDLADVSVELRTLSRDGSVAANVRARAAWAAAQAQWGLRDSAAVVLKEIAFDRAVARHVRVKAARWLAFVSAVCRPEARALLAELRSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T240</accession>
    <name>A0A7W7T240_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR system Cascade subunit CasB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013382">
        <property type="entry name" value="CRISPR-assoc_prot_Cse2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038287">
        <property type="entry name" value="Cse2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09485">
        <property type="entry name" value="CRISPR_Cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02548">
        <property type="entry name" value="casB_cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="23542" checksum="ABA05E04604AD9C4" modified="2021-06-02" version="1">MTTTAEEGKPPAETLRRRELTPVGIEVHERIQIWQRDYLANRSAAVAALARLRRGVGKRAGTVPDLLLYTESDKFAGEDAGNDPTTQENAAHIAFTLYALHQQSHRAKQMNRRGYGLGKSLRLLHPGEFGEPLPPIVRRFQALSTSASFDEVVHHLRGAVQLLRTNGIPLDYGLLADELTWWQHGGASAIPLRWGREFYRTPKMAPDSAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2B0</accession>
    <name>A0A7W7T2B0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_002623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="354"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="386"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4965264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="596" mass="62285" checksum="404840F770BC6DB3" modified="2021-06-02" version="1">MDALLRRSPHPLLPGLLLAVVATAVIASTASSYVLFLAIGAAVNTVYLQSYGLITGRAGVLSLCQLSFAGIGAYVVGWAHVVDVPGGFAVWLLLGGLAAVVAGLLIGLPALRLRGVNLAVATFAFAMAVDVVLAGVPFPGREKFDFVPRPAGFTDDAGYFVFTMTVVTALAVGLWFLDRSRTGGALVEIRHSERAAAAHGISVVHGKLTAFALSAGIAGIGGGLMAGRLGVVSAISFSTFASVTLFAIAVFVGTHNVEGAIAGGLLGVAFPVLIDTIGVPQDLAALFFAVGAVQVLRLGMSQTDLLRAKRRRRRVARAEAETDEDSTAPILHRPVVRVGADGWPVRDPDAEPALEVRNVTVRFGALTAVDDVSLIVPKGHVVGLVGPNGAGKSTLVNTVTGFTDRYTGTVLLDGRPVDKLPAHLRARAGLRRGFQQSRVPTSLDVGLFLRVAAGRPLTSAEVDEQLSLFGCPGADTPMETVDVATRRLLEVAGLALGRPPVLLLDEPAAGQSSAETRLLKRRISEIPERYGTAVLLVEHDLELVRSTCDSVVVMDFGRVVASGPPDDVLRDPVVVSAYLGTAALPTPDPRRETTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H2</accession>
    <name>A0A7W7T2H2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9274" checksum="6EDD9DC7277FE2C2" modified="2021-06-02" version="1">METVDESLRFTDVDDSLRGPAAGPGALWRIGHDLPGRQGIAHGLAVHYWFDVVDDLVTAEPKAFDAIVSELDRLGDHAALNPIPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X5</accession>
    <name>A0A7W7T2X5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VanY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="1">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17227" checksum="44BB316EE66B66C8" modified="2021-06-02" version="1">MIASALVVVLTACGQAGRTEEDGSIAEGERISPHADHPAIRRMDPVLLAAVRRAAADAKQAGIEVGITSGWRSKEYQQLLLDQAVSHYGSLREARRFVSTPETSAHVSGKAVDIGPTDAADWMGRHGAAYGLCQVYSNEMWHFELLTTPGGQCPEQRGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T367</accession>
    <name>A0A7W7T367_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="18931" checksum="B1AD955A328608FB" modified="2021-06-02" version="1">MPSKDFARIALFAAIMVVLGLFPLIELPLVPAPFTAQTLGVMLAGSILGARRGGLAILLFVVLVVIGLPVLPGGRGGLSVILGTTGGFVLAYPVGAFVVGLLTERLWKRYNLGWALLCNAVGGALVLYAIGIPWMSVAADLPFGPTLVGSAVFLPGDAVKVVIASLAAVAVRRAYPLIDADRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L1</accession>
    <name>A0A7W7T3L1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6859" checksum="A6820DDD12EE8615" modified="2021-06-02" version="1">MTDLTYSERRVATLAALGHSNRAIAMRLHITVSTVEQHLTRVYRKLSVASRTELKGHQALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4L3</accession>
    <name>A0A7W7T4L3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="318"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="463"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="677" mass="73832" checksum="25ECF43368FEB000" modified="2021-06-02" version="1">MDEFERLAALHEYGLLDTPADEELSAVVRAAAVVAGVPTATLNLLDADRQCQLTTTGFAGADSPRQDSLCNVVVAGGEAVYTRDASADGRFAASPWVTGVLADVRFYASVPLTTPEGHVLGTLCVFHDQPVDLDRTRLDALHDLAIVVLALFERRRQARLFADLAAETEAQRELAARYAGELEVRQELINAVHETAGVAIVACDQDGHLTLFNRTARAWHGLEADAGLDPDQWSARYHLRAADGITPLNADDVPLRRALRGETVENVEMVIAPEDADPIRVLCTGRALRRADGTPLGAVVTMSDITAERTGREDIADRERLLASMLDTTTDACVATDSRGAVTAWNPAAEAMFGWRAAEAFGRRLTDLIIPERLRAAHDQGLARRAAGSEARLTGLVEVPAVRRDGSELQVELSLGSFTWRGERRFHAFLRDVTERAAARARLAAANVELTEANAELDRFTAMVAHDLKSPLTTITGYTELLAERDDERERVPLAAIGRAATRMRVMIDDLLDYARATHEPLDLRPVDAGETVDLLVDEMDPERSVRARVTRDVLPPLWTHPTLLRQVLANLIDNAVRYTAPDVLPRVHVSAQEGPAGTTIRVTDNGIGIAPESREDVFDLFHRERTGDGYRGTGIGLSTCRRIVERHGGRIWIEPGSERGTSVCFTVPNPVALVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U7</accession>
    <name>A0A7W7T4U7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030542788" evidence="1">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20945" checksum="933875733EEA8A16" modified="2021-06-02" version="1">MLKRLLSTATAIAALGVLVLGGNASAAPDPTVPEEAQVATFVEGSEEASPLAKSDYIAGAAANGQALTQLQKDDLNSAAVTCWSWDAWRQAKNVFGARLWTSHHRVKWCGDGSWIRAHAYTERWGETHWIGWTDKGLTQSGQQYGVNWNRYNSWTQRKFCYVDYFNCIQESNPYHNTTVFPNGKGQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y6</accession>
    <name>A0A7W7T4Y6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22263" checksum="4BE82F6078F1308A" modified="2021-06-02" version="1">MTEQFDAAFWDERYRSRDAIWSGRANPQLVADVAALPPGTALDVGCGEGGDALWLAEHGWEVTAVDFAPTALARAEARADSLGLGGRITWTRADVTALPADLGPFDLVSAQFMHLPGAERTTLVRALAGLVAPGGTLLFVGHHPLDLENPEIGRPDRADLMFTAEQVAAGLDDGWRIVAETRARVVDGLTVHDAVLNARRHSPSVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T501</accession>
    <name>A0A7W7T501_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030853915" evidence="2">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15267" checksum="22ED98AAEFD12705" modified="2021-06-02" version="1">MRRLPVLLLLLLAAAGCAMVTDLTDLATRLENEGYTVVRVHHDVTNAVDTLTVEVKNAVTSAGEKDPAEVAWTKYTGELDELVVRLDGRESTYSAIELERRFGPRDEQSSSTVPIVLAVLFVVGCVVTAVVVVAAKRDRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5A8</accession>
    <name>A0A7W7T5A8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="265"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="37428" checksum="BBA4FF2D423852B0" modified="2021-06-02" version="1">MGAVVAADLGWAIVVAAGSAGRLWGPVGGVVATVLYCGASVGCLMTRGHAAWRLGGALVVGLWVCVFAVYASLPLLYLVVVVAPLRMRLGQAMTSTALAVCGFAFVGSTYWLPRGSVAGIGIGLVAAFLISALANQIGVTRRQLTEVARARADEAMLAERQRLAREVHDVLAHSLSAQIVHLEGTRLLLQLNKADAAQVLSRVTRAGELARDGLREARRAVVALRGDTAPMVGQLVGLVDEFRAVTGHRCTLAFTGDDNFRPEHAAASTVVRVAQEALSNVRRHAPGADVAIVLHRDRECLELDIRDSGPSRPRPPIASGGYGLAGMRERAELLGGRLHAGPDGAGFRVRLRIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E0</accession>
    <name>A0A7W7T5E0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9004" checksum="73B2DDA04E3B53AE" modified="2021-06-02" version="1">MTHEHPRTVGDLIAALSGYDPATPLRVAAQPGYPMEHLLARVVCTPDDAESWGVRPTDPPVVWLGTGEQVGYLPAIAADALGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F3</accession>
    <name>A0A7W7T5F3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025359">
        <property type="entry name" value="DUF4263"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007636">
        <property type="entry name" value="Restrct_endonuc_II_XhoI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14082">
        <property type="entry name" value="DUF4263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04555">
        <property type="entry name" value="XhoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="423" mass="47079" checksum="DD6D53F65930595D" modified="2021-06-02" version="1">MSLIESELVRAGLDRSTIRRDEPVALPGAYNPAPRRWDLVVVEDGIPVAAVGFRAATGPSFGNNFNNRVEQILGDAVNLGRPYEPEALTGFKPCLALCFVLEDCESSAGPIQTRRGHFADDFGFPEGASYKDRYGIFFERLVQDGRYDAICYLASTPSDQPSVSEPRDEMGFGRFAQSIADRVVEIRKLREDSALDPVEFGRELAKRDDLGKVILGITSTPRGLSAAEAAVIEHRRQLVARLRELALADHVTETKMHNALGTSYWVFGGQYVGIAARRTLMPLDQYDIPLVCADRSLHIVELKGPDCKVVRKHRNHLIVADEVHEAVSQCINYLRSLDDMGTTLQTVHHNELGLDYDYRRAKGTVVIGHQDRACPAGVTREQVNQTLRSYNAHLSRVQVLTYDDLLDSAERALNFEVSETRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F9</accession>
    <name>A0A7W7T5F9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme F420-reducing hydrogenase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="41" mass="4737" checksum="83BEB7EC8AB999FB" modified="2021-06-02" version="1">MADHLDLDDHALVSLCERAIRNHDPCISCSAHFPHFHRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q1</accession>
    <name>A0A7W7T5Q1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="12254" checksum="85F905799F35B4F6" modified="2021-06-02" version="1">MDDLTEMLKGTLEGCVLEIIGGEETYGYAITRRLNELGFADVVEGTVYTILLRLEKNGLVQVTRRPSGLGPPRKFYALNDAGRERLAAFWAKWEYVTSRIDKLREDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5W3</accession>
    <name>A0A7W7T5W3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RND superfamily putative drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="180"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="716" mass="73695" checksum="D10965446E374DC9" modified="2021-06-02" version="1">MALLLYRLGLLAYRRRSLIVLAWLLILVGAGVGAVTLGGKTADSFAIPGQESTTALEIIDRKYGAQAGGTTARLVLKAEEGHTLTEPATADAIKKIVADLRALPGVVNASDPLAPDAPTVNADRTTGYSTVTYGVGPGEVPDDQRTALYDTVKNIRGLTAEVGGEATNVPPPVGGPAEAAGVVIALAILALTYGSLVTAGMNLLTAAVGVGVGTLGIMIATGFMDLQSTTPVLAAMLGLAVGIDYALFIINRFRQELRHGADVGPAVANAVGTAGSAVVTAGVTVVIALAGLAVVGIPFLTQMGVAAAATIVVSVFVAITLVPAVLGFIGRRALPRRQRLPGGDPDDHERGFFRGWIGGVTRTRVVALLLSIVALGVIAIPAADMRTTLVQKPQAETTQARAQDMLAEAFGEGFNGPLLVLLEGDDAAGEAARVSEKIRGFADVAVVTPPVPDQAATAAMVTVIPKSGPASEDTEKLVTDLRDLLHGLDGVTGYVTGATAVSVDVAVSLDDALPVYLVLVVGLALILLVLVFRSLLVPLVGVLGFLLTIGASLGATVAVFQWGWLSAVVNLDATGPLISLTPILVIGILFGLAMDYQIFLVSRMHEAHHLGARPHESIAVGFRRAAPVVMAAALIMFSVFAGFVPAGEGPIKSIAFALAIGIVVDAFAVRMVLVPAALALLGESAWWLPRALRWLPTLDVEGTALDTRDPAVGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T640</accession>
    <name>A0A7W7T640_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16391" checksum="AB7618D5471BDF95" modified="2021-06-02" version="1">MDDLVDRLRDLLKAVRLVKQFRSERHPEFPVGMIATLTLIDRSGGCHAKELAATTGRDPSTVSRAVGTLVAHGLVERRIDPVDRRAGVLAVTDAGRGALAEARTWHDDLLRRVLADWSPAEVTALTAALGRLTTDIGKALDFHHTREAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T656</accession>
    <name>A0A7W7T656_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="47" mass="4877" checksum="51EB5B766B756D48" modified="2021-06-02" version="1">MTGRPTGPVAADRSGPTATCLLATVATNPSGPVVEAVAWHGFRGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T690</accession>
    <name>A0A7W7T690_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA1 family chloramphenicol resistance protein-like MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="379" mass="38167" checksum="5860B32BCB1419ED" modified="2021-06-02" version="1">MGTSEFMLAGFLPDLAGDLHVTVGTAGTLTTAFAVGMVVGAPLVAVLARRWSGRVLPGFVLVFLATHVVGATTSSFAVLFATRVVAALAYAGFLAVALTTATGLVPPDRTGRALAVLLSGTTLATVVGVPGGAVLGALSGWRSAFWVVTLLCVPAAVGVLTGRPARTAPAARPALRSEFALLGRPRLALAMLLGALVNAATFGGFTFLAPVVTDTAGLDGLWVPVVLMLFGVGSFFGVTAAGRLSERHRDRVLAVGGPLLSLGWAALALLADESVALMILVPVQGALSFAVGGVLITRVVHEASGAPTLAGAYATAALNVGAAVGPLVAAGTSGTRGPLWASVALVALASLIAFAARNVLTAREAHDAGSGERRRTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T697</accession>
    <name>A0A7W7T697_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenazine biosynthesis protein phzE</fullName>
            <ecNumber evidence="3">2.6.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.86" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="118"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="442"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="628" mass="67975" checksum="94F744DE2DEF8CF3" modified="2021-06-02" version="1">MTAWLDRVLAPDAPAFALLHRPGSVGADRVDLLFGDVREVDLIADIALPADDVRDRHDVLAVLPYRQIRERGFDHADDGEPLITLTVADQRVLPYAEVLDTLPDAPIDLGAGGFDLDDERYADLVRRVVTEEIGRGTGANFVLKRSFTAEITNWSRRTALAFFRRLLGRDPGAYWTFLVCAGGRTFVGSSPERHVSLDAGLAVMNPISGTYRYPEAGPDPAEVLRFLADAKEANELYMVLDEELKMMGRVCDLGARARGPYLKPMNRLAHTEYLIEGRTTADVRDVLRQTLFAPTVTGGPLESACRVISRYEPGGRGYYAGVVALFGRDAAGERSLDSAILIRTAEVSASGRMTIGVGATLVRDSSPESEAAETRAKAAGLLAALRGEDPPAAFARVPELGADPAVRAALAERNVPLADFWFEDPATRSRRVPAAVGRRILVVDAEDTFTAMARTLLRAVGFDVSVARFDEAYAVDGYDLVIVGPGPGDPNDVTHPKIAALRGLVTTLLARGIPFFAVCLGHQVLSTLLGLSVRRREVPNQGVQRKIDFFGRTELVGFYNTFSARTTADRVPCAARGGVVEVFREEDEVHALRGPGFASVQCHLASVLTRNGAEILGEILGDLTADAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K7</accession>
    <name>A0A7W7T6K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
            <ecNumber evidence="1">4.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.12" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008473">
        <property type="term" value="F:ornithine cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023866">
        <property type="entry name" value="SbnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03944">
        <property type="entry name" value="dehyd_SbnB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="34868" checksum="4D8C94782F84BCD7" modified="2021-06-02" version="1">MLILTHDEVAGVLRDREAELIELVAAAYRLHDEGRSAVPHSTFLRFPDDDRNRIIGLPAFLGGDRPSAGMKWIASFPGNLEKGLERASSVIVLNELDTGRPIALLESSLISAKRTAASAALAAREFGPAGLSGAGFVGCGPINLEVLRFLLVAVPTLAEITLFDLSPARAEAFAAKARELSPTLKVAIATDLDDAVGAHDALSLATTAGTPHMDLSKARPGATVLHVSLRDLTVETILGAQNIVDDADHVCRERTSLHLAEQHTGGRDFVDGPIGGVLRGRVAFTRDTTRPLVYSPFGLGALDMAVAEFVNAEAAARGLGTTVAGFLPGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N9</accession>
    <name>A0A7W7T6N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease D</fullName>
            <ecNumber evidence="2">3.1.13.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033890">
        <property type="term" value="F:ribonuclease D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="205"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="41824" checksum="26A4073F0646C82B" modified="2021-06-02" version="1">MVADAPSLERAAKALASATGPVAVDTERASGYRYSQRAYLVQLRRAGAGTVLVDPIALGGRLDPLVAALDGTEWVLHAASQDLPCLAELGLRPAVLFDTELAGRLAGFERVALGTLVERLLGYRLEKGHGSADWSRRPLPADWLNYAALDVELLVELRDVLERELDRQGKLGWALEEFEAARTAPLPRPRAEPWRRTSGIHRIRSPRQLAAVRSLWETRDTVARTRDIAPGRVLPDSALVEAAVRNPPDEATLSGLPVFRGRAQRRMVGEWFGALQRAAALPKAELPDPAQQHDGPPPPNRWADKDPAAAVRLAAARTALTAVAEANTLPVENLLLPDLVRRTCWQPPADLSVEGVTAALREGGARSWQLGLTAEALAKALATRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T706</accession>
    <name>A0A7W7T706_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="23997" checksum="974906AFF04B06F7" modified="2021-06-02" version="1">MRFLRRSAEEATTETPAEATPEESSAESGRTPGKGRATPKRREAENKRRGPVPPPPRTQREAFKRMRGNKQSKDERRAAAVERRERMMAGEEKYLPPRDRGPVKAYIRDVVDARRNFMGLFMPMAILVFIALFVPNLVVQQYATLLTTFMLLAMILEGFVLGRIVSKRVRAKFPKETVRGLSVGWYSFIRASQLRRLRVPKPRVSPGDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T718</accession>
    <name>A0A7W7T718_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate dehydrogenase/fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="4">
        <location>
            <begin position="431"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="513" mass="54246" checksum="E9098BD76761819D" modified="2021-06-02" version="1">MITADVLVVGGGPAATWAALDAARAGADVVLADKGYCGTSGATASVGTGVWYVPPDPAAREAAMASREALGGYLADRRWMGRVLDQTYANVADLAATGRYPFPVGPDGAQLRTGLQGPEYMRRMRVLVRRAGVRILDHSPVTELLVDDDGAVAGAAGYRRQEHEDYAVRAGAVVLATGGCAFLSKALGCDVNTGDGALFAAEAGAELSGMEFSNAYGIAPEGTSVTKTAFYSYATFYREDGGVLEGAGSQRGRSVIARTLLTGEKVYCRLDLADDAAQRAMRLAQPNFFLPFDRQGIDPFTDRFAVTLLLEGTVRGTGGIRVVDDGCATTVPGLYAAGDAATREEICGGFTGGGSHNAAWAMSSGTWAGRAAAAYARSLGSWSARRTARPVGGAGLRPTGKPVDGHREVVRAVQDQVMPYDKNYLRHGDVLSHAVKELDDVWVDARRTLHGDVVRSRQAAAMVAHARWMYRSALARTETRGMAKRLDFPAQDPAQHHRIVTGGLDEVWTAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T777</accession>
    <name>A0A7W7T777_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trans-aconitate 2-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.144</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.144" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27640" checksum="F9207D9E19337E1E" modified="2021-06-02" version="1">MWDPTRYLDFADDRARPFHDLVNRIGAEDPRRVVDVGCGPGHLTEVLALRWPKAVIEAFDSSPEMVESARGRGLAATVGDVRTWQPEPDTDVVVTNAVLQWVPGHEDLLRRWLRALPSGAWLAMQVPGNFADPTHRLVHEVVGESWPALRGLLREAPVLDPLGYARVLGGASVDAWETTYLHVLTGDDPVLEWITGTLLRPIRAALTDEAWQAFRDELAPRLRTAYPPDDDGVTHLPFRRVFAVARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G9</accession>
    <name>A0A7W7T7G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioester hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="18"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15685" checksum="81A4ADE667DABD63" modified="2021-06-02" version="1">MGVFVTEVRPRWSDMDAFGHVNHANTVTLLEEARVDLLFTEAARHGVADMAHGVVVARLVVDYLSPLVFTGDEIVVEMSVRELKSASFTLVYTVRNGRREGSPVVATAETLMVPYNLTAGRPRRLLDAERDFLAGWRAGGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T875</accession>
    <name>A0A7W7T875_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="20956" checksum="843E596A7F6C2BDF" modified="2021-06-02" version="1">MKLLLASRNAKKLGELRRIVLAEELTGVEVLGLADVPEFPEAPETDPTFEGNALAKARDAFAATGLPSVADDSGIAVDALNGMPGVLSARWSGRHGDDRANLDLVLGQLRDVPDDRRGAAFVCTAALVAEGVEVVVRGEWPGTILRAPRGVNGFGYDPIFRPEGHDVSAAELEPGEKDALSHRGRALRLLVPHLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T889</accession>
    <name>A0A7W7T889_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent HD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="entry name" value="PTHR21174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="22393" checksum="5403D46A6F64FD08" modified="2021-06-02" version="1">MTDLDAWWDEAVAVLGGTVDAGDLAERYAEPHRGYHNADHVRAVVRDVLDLAADRSREERAVLVLAALAHDVVYDGVPGQDERRSAEWVRARLDVPERDRVAEIVLATVDHRADDDLTTLLLDADLAVLGGDTESYERYRRAVRAEYAHVTDEAWREGRAKVLESLLGRDPLYRSDRARARWEARARVNLAKELSDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T895</accession>
    <name>A0A7W7T895_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biosynthetic protein FliR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26202" checksum="0924866C20A7BE59" modified="2021-06-02" version="1">MEAAIPTGTLLALLLATARTAAWLMVSPPFNGRAIPTTVKGMLALAIALPVLPGTSAHVPELTTWSVVSGVVTQAIVGAGLGFLTALIFAAIQAAGDLLDVFGGFSMAFAFDPMSFSGNNSVLGRFYGMLATALLFVTDGHQIIIRGFTLSFEAVPLDHGLSLSTLGSLLTEGLGRMFLSAIMIAGPLIVVLFCADIGLGLLNRIAPALNPFAIGFPAKIGLTLLLVGSAMFLLPAAVRGTVQGAVEAMFKAMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C7</accession>
    <name>A0A7W7T8C7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">F4559_005560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="18153" checksum="69F9A2543F37F627" modified="2021-06-02" version="1">MVKERGQKVIASNRKARHDYTILDTYEAGVVLVGTEVKSLRMGRASLVDAFGQVDDGEIWLHALHIPEYVAGTWTNHEVRRKRKLLLHRQEIERLIGKTKESGLSLIPLQMYFKDGYVKVELALARGKKAYDKRQDLAKKDADREIRKAHGRALKGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T914</accession>
    <name>A0A7W7T914_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiG</name>
        <name evidence="8" type="ORF">F4559_006162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26402" checksum="D61740761D0D5E24" modified="2021-06-02" version="1">MDDPLVIAGREFGSRLVMGTGGAANLSVLERALVAAGTELTTVAMRRMDAGGGTGVLELLRRLGIETLPNTAGCRTAAEAVLTARLAREALGTSWVKLEVVHDDRTLLPDPVELLDAAERLVDDGFVVLPYTNDDPVLARRLEDVGCATVMPLGSPIGTGLGIRNPHNIELIVARAGVPVILDAGVGTASDAALAMELGCSAVLLATAVTRAQDPELMARAMRSAVEAGRSARLAGRIPRRFWAHASSPDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A4</accession>
    <name>A0A7W7T9A4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma factor for flagellar operon FliA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="6">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="34610" checksum="0E54EF3E2426FCC2" modified="2021-06-02" version="1">MTGNIKTQQPALDDQYESTGTGFDAEDGKHRNDDATMRELAEAHLPLVRHVVRELLARVPAHVRRDELMSAGYEALAHAARCFDASRGAPFSSYANVRVRGALLDELRRADWASRSVRSKARKLDTARDAFVVAHGRTPSDVELGEKLDMSVRDVASIRDDVQRSVLLRLEGAVGDTNDDEVSLSIPDPSPNPEQTLLERERIGYLRDAIEALPERLRTVIEQYYFAGRQMSDIAADMGVTESRVSHLRAEATVLMREALNTHLDPDRVTDRDATGCAARRRAAYYASVASQATLHSRLARTSSTGMPVDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T2</accession>
    <name>A0A7W7T9T2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="80"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="22994" checksum="2BF9C2788C7CB45A" modified="2021-06-02" version="1">MRGEPRPRVPVPASKESSLTLERGLALLQAVADAESEAPSISELAAAIGASRAAVYRLLVPLQARGLIRREGSKVRLGLGVLRLASNVLPQLRLAAQPALRTLAETVGATAHLTVADGTEAQAVAVVEPSWTAYHVAYRVGSRHPVHRGAAGKAIGLSTEGRQWVHSTGELQPGAYGFAAPVRGVPGLRASVGVVALEKLDGEVVGPQVVRAAQEVAEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W2</accession>
    <name>A0A7W7T9W2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="40741" checksum="54409E3183CE0BF9" modified="2021-06-02" version="1">MTWQNELRKLDEELASGRISADDYRRRRDEVLTQASAAPAAAPQQPAQPAPGQPSQGPFPPPFQWEAKPPAATAESTQIMRPAQPPQPQQQPQQPGDADRTQVVPGGAPRQDADRTQVVPGGFPQQPQTPPPGYPVQAFPQQPPQGGYDATPPWGSSDQLSDPWGVKQGPEVFDESGGGGKGKVVGIVLAIVLLAGIAFGAYWIWGRGNGDNQAGNDSTATPTTTTSTTPSPPPDPLPVGKIKGKVSTNKSVTAFTDVPNLKYLLDSEAALYTTAGGGKTKLAQFTLDDGSKGIVLIVQATDASAAKEAVTGLYDLQINNGMTPFASTPTNVLASEVDAKGGQQARLRGHYASKDLIVRVDVTAPTLAAAQKGFTDSLDAQLEVLKADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB10</accession>
    <name>A0A7W7TB10_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018735">
        <property type="entry name" value="DUF2277"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10041">
        <property type="entry name" value="DUF2277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9731" checksum="5AA1BDBB85C03AF1" modified="2021-06-02" version="1">MCRNIRVLHNFEPPATEDEVVAAAVQYVRKISGAAKPSAANQEAFDQAVRAVAEATRVLLDSLVTTAPPKDREVEAAKAKERSAARFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBC6</accession>
    <name>A0A7W7TBC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="26752" checksum="A7C90DC34BAC0494" modified="2021-06-02" version="1">MGSSAGTLHDFVLDLLSDPDALADFQADAEGSLAAAGLGDITAQDVQEVIPLVLDYAPAGRIPALDQHSMFTDVPLDDATSAVGQLQAVAQQLALSGVTGTSDVNLAAAGALSADAHGLEIFGGYAGWGAVDSVGSISAAVDGDFAAVHDVTSTLDRVPEPADVAGQATAAVPDVVPDTGTLPVPAATTDVLGPLHSTIGNVVGTVTDSVALDLDHDTAGLGVGQAPDLGQVTAPLESAAPVAVSDVTGHGVTDVDHADVPVVSDLGDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT03</accession>
    <name>A0A7W7WT03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29937" checksum="B3685A02747F2099" modified="2021-06-02" version="1">MARTPRLAAGRARALGLPTRGTTNPNRLRRVDRFVAHRFRDLLRDTAEPLVVDLGYGSSPITTVELAHRLRPLNPDLRVLGLELDAERVEAGRLAADPPRLDFRRGGFELAGRRPHVLRAFNVLRQYTEEQATQAWTTMVSRLAPGGVLVEGTCDEIGRRCSWVTVTSDGPQTFTLSCLPADLETPGDLAERLPKALIHRNVPGERVHALLLDLDACWAAAAPFAPFGPRARWVEAVRSLAGRGWPLLDDRKRWRLGEFTLRWDAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT34</accession>
    <name>A0A7W7WT34_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031296483" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="26850" checksum="50ECC091D726FC89" modified="2021-06-02" version="1">MRRFAPLAALVLMIALAVPATAAPSAGLEYRVFATREGLVGGTTANGHVITDRDHFVALPSRLGLSPKGTGTYSVKVCASNGRCEWAPVWDVGPWNTKDDYWNATRQTWTGLPQGKPEAQAAYQDKYNGGKDQFGRTVSNPAGIDLADGVFWDGLKLTDNAWVTVTFEWTGTAPVAYVRTEGGPLNVRSAPSVTASQVGLAANYAQLRLECQTTGQKITGAQGTSAIWYRIASGMFVSRTYLVDAPTVNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT86</accession>
    <name>A0A7W7WT86_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="27"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11369" checksum="8219E75DBD2736A1" modified="2021-06-02" version="1">MRTLNDETFRETVGGGAVLVEFSATWCPPCRMVEPVLDEIDRELAGLDVYKIDTDESPVTARDQKVMSAPTMQLWRDGELVAQIVGARPKSQLLAWLEPHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU6</accession>
    <name>A0A7W7WTU6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TM2 domain-containing membrane protein YozV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15132" checksum="A6CB78F73A2C8890" modified="2021-06-02" version="1">MCGSCGASLQPPNTTCQVCGTAAWPTPPPPQAPPPPNYGQPTFAQPVPVAPGFGYGVPMRVVTPKSSGIAVLLSILWLGAGNLYVNQTGLGIGLLLANFPLWLLAVTVLGWFIAFPLWIIGVVVSTVLAAQGAKEYNMRNGIVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX8</accession>
    <name>A0A7W7WTX8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase</fullName>
            <ecNumber evidence="9">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="155"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="263"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="374"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="453" mass="47918" checksum="F16415BB9EA437A1" modified="2021-06-02" version="1">MAVRDLSGIVKAYDIRGVVGEQLDAEVVRAFGAAFARLVGSSAVVIGYDMRDSSPGLAAAFAEGVTAQGVDVVDIGLASTDLLYFASGRLDLPGAMFTASHNPARYNGIKLCRAGAAPIGQDTGLGQIRSDAENGTPDAQGVTPGTVTKQDLLDDYAVYLRELVDLKAIRPLKIVVDAGNGMGGHTVPRVFDGLPVEIVPMYFDLDGSFPNHEANPLDPKNIVDLQKRVREEGDADAGLAFDGDADRCFVVDERGEPVSPSAITALVAVRELAKSPGDTIIHNLITSHAVPEIVREHGGTPVRTRVGHSFIKEEMARTGAIFGGEHSAHYYFRDFWRADTGMLAALHVLAALGGQDGPLSALTSDYERYSASGEVNSTVADQAGRLAAIKAEFGGRDGVELDELDGLTVVLPDGSWFNLRASNTEPLLRLNVEAADPASVAALRDEVLSIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTY1</accession>
    <name>A0A7W7WTY1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate--glycerone phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.121</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012844">
        <property type="entry name" value="DhaM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="11781" checksum="2ADE09CB7589F34F" modified="2021-06-02" version="1">MISLVIVSHSRLLAEGVVELAAEMAPHVSITACGGLSGRLGTDFAAVSAAVGRASSGVVILYDLGSARMVAELAAEGASVPVVVVAAPVVEGAVAAAVAAESGASLPEVATAAAESVRWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ5</accession>
    <name>A0A7W7WTZ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="46358" checksum="F0218BE94B2CFDE7" modified="2021-06-02" version="1">MAVRRTGFVRARKAAGFTQESFAEAMNVDRSTAARWEAGTNEPLPYQRSKLARLLKVGPSELDALLNPAPEVLPQRTTVAASPVEGGDDVERKTFLRVLAGSVAGLAFSDPMQEFAARAASAGRGAKIGQADVDHVRQLSRLFAGQDHQYGGKLSTRAVMTQLSASVELTEGSFADDHVRTGFLSAVAELADTTAGICFDAGLHSHAERAFRFGVGCATESGDWAMRAKSLSGLANLSVHRRHTDDALSFAEMALVRADRLSPKVGSMMYTRHARALGLAGASRSGDCRAAVGKAEDLFAQTSTDDEPAWICYYNAAHLERDSGRALLQVALNGGGHQEARRRLETAVARFPEGHSRGKALAKANLALLMMTCDDPHEAVRLGDDALASVGSVRSDRVDDALSQLSQAAHRRSDIAEAHELGQRIKQKLGVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU33</accession>
    <name>A0A7W7WU33_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR system Cascade subunit CasE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01101">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22105" checksum="C8951890EFD61404" modified="2021-06-02" version="1">MTKVVLDHRNPQTVEDLRNAYQMHVRVREIAEGLPDPDGGRLLWGLHGTTLLVQTGAAVSPLALPAGYAVSVHSANLASRLDRITAGSVVRWAVIANPTRARAKATAVGPDGVPVRKSRGQPTPVALGERNEWITRRLAPALEITALTGRPLPAAAGTQIRTRHRVHHSRHLWQGTATVADPDVLRGLVSSGIGHGKAFGCGLLLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU51</accession>
    <name>A0A7W7WU51_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="14116" checksum="25971DD38457B38E" modified="2021-06-02" version="1">MLIGELAALTGTSRRLLRYYEEQGLLASTRAANGYREYDERFVDRVRQIRGLLDAGLPTRIIRQILPCLDKPRIIHFPDATPEMLATLEHELSRMTERIEFLTRNRNAIAEYLAAVRSCAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC7</accession>
    <name>A0A7W7WUC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="53"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="207"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="466" mass="50839" checksum="110F06C9C6B83B99" modified="2021-06-02" version="1">MTSHVIGTAASAPGTRGRPRRGPLGHLQRPGSTRLLDDGDVTVRRSLLPSGLRVITERVAGVRSASVGLWVRVGSRDERPEVAGAAHYLEHLLFKGTTRRTAARIAEEIDAVGGELNAFTAKEHTCYYAHVLDEDLSLALDLVCDVVFDALCEPRDFETERGVVLEEIAMRDDDPEDLLHDAFLDALLGDHALGRPVLGTEQSIADMDRDSLYRFYRRHYTLPRMVLSVAGNVDHAHVMRLARKQIGDRLASTGTPVVPRTGRARIAARRDLVLHDEDTEQAHLMLGVRALDRHDDRRFALNVLNAALGGGMSSRLFQEVRERRGLAYQVYSSVGLYADAGTLSVYAGCQPERLGDVAGVVRDVLSTVARDGLTDAEVRRGKGQLRGGLVLGLEDTSSRMTRIGKSELNYGDYLSVEGTLARIDAVTTEDVAALARDLLRRPVAAAVVGPYAHADDLPAQVHEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF6</accession>
    <name>A0A7W7WUF6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="36772" checksum="2E2303277A361701" modified="2021-06-02" version="1">MTLLVTGAAGFIGSHFVRHRVSTRPDERVVALDALTYAGTETNLADVRSRIEFVHADIGDSGVVEKVLASYGVTTVVNFAAESHNSLAVLDPGRFFRTNVLGTQSLLESCRRVGVSRFHHISTCEVYGDLDLDATSAFTEASPYRPRTPYNASKAGADHAVRAYYETFGLPVTITNCANNYGSHQFPEKVLPLFTTYALDGRALPVYASAENRREWVHALDHCRAISAVLDRGVVGETYHVGTGVEASVSQIADLVLSELGLPLSLKETVPDRPGHDRRYLLDSSKIRRELGWEPSVSFEEGVRETIRWYASNRSWWEPLRDRSPVVESSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG7</accession>
    <name>A0A7W7WUG7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="623" mass="67269" checksum="BA1FECE9199EC241" modified="2021-06-02" version="1">MTGAPSYDLLSRPWIPVYTTGGEGEREVGLREALQSAHRHNLARLGLSGEGLVLLRLLLAVYEAAAGPVDDDGWDAAWRAPTLDPHGRIADYLDRWANRFDLYDPDRPFAQCAHLAEPNRGAVELHPAWLGGQGAAWFHPGLYRGADHPPWEPGEAARNLLVRMAYDTGGIKPAAPGDPAGKGNKVYGSRIGPLGATVRLVVLGATLKDTLLLNLPPAPRAPGDAPEWERDEGPPAGIRVDRVPAGRLELATMPARRLRLFPDRDGRVARWAWHDGDRVAGYWNHYHRLDPTLLCRDSRDGQGTADPDAFDPYGHQPRWWLLTRPLHVPPAADPRRWHSGALVHAVGAARRGLLPADLPLRVWVSQAVYNTHGSVAVGDHNGRVDLGPVGVHAAEPTARVVAFLDHQTAATLRGLAVAAAEALPHVTLGDRLTPDAYALERLWSDTTRRLAALDTDPSHEELAGVCLDYGRRLVGLCAQALDRLPFGGSSGMLMRAKAGVALERYVAYFTDLPTKPYPRKVTPVQARAFAAAAAGARARRSGGRKPGSGRGAGGGRPSPMLVAFGEEKTQAQWARDERCVVSVSALRSRLINGWDPEAALTTPGRRAPGAAPDDTEREGEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUI4</accession>
    <name>A0A7W7WUI4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TROVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="PTHR14202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="SSF140864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="5">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="525" mass="57062" checksum="4A960A1AC06DE39B" modified="2021-06-02" version="1">MSRFNTATARPVGSGPIHTESTPSTLTHEGAPGYARDTKSALFLLAVSNMAGEDTYYEKAGDRDARYADLVHAAALEDPKWTARFLAWLRSEANMRSAPLVGACEFVRARLTAQRRRRGANRAVIASVLQRADEPGELLAYWTSRYGRAIPKPVKRGVADAVLRLYDERSLSKWDSAGRGFRFGDVLNLVHPTPRADWQGDLFRYALDRRHGNAEEIPESLTVLRQRGDMLSWPVEQRRALFANDVVASSVLRTAGMTWESVAGWLQGPLDARVWEALIPSMGYMALLRNLRNFDEAGVSDQVAASVSARLADPGQVARSRQFPFRFLSAYEAAPSLRWGHALDQALQASLAQLPALPGRSLILIDTSASMTGTSLSARSKVTPAKAAAVFGVALAAKGVDVDLRGFASGEFVHTVPRGGSVIREVDRFLSRIGEVGHGTDIAGAVRRSYNGHDRVVIVSDMQTMTGGVDTAVPGHVPVYGFNLGGYRAAAMATVGNRHEFGGLTDATFRMVPLLEAGRNADWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR3</accession>
    <name>A0A7W7WUR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031333961" evidence="2">
        <location>
            <begin position="32"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20476" checksum="B5A0370CD31176BE" modified="2021-06-02" version="1">MSHQVKVVIVAGVVASLAACGATIPGAPTPAATGRGSTAISPNVTGSQPPHGDDVGVAKFLDKPCDLVKADQLALLGRIRETKPGTNTLGPMCTWKGTEPTKDNTYELSLVTKNATFDSMVENFRDYPIFRETTIAGLTAVSADRTNGTSNCSTLVRTSAKNPIFVQTSLPATGQGTADKSCQASEKVAAIIVGNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY2</accession>
    <name>A0A7W7WUY2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20946" checksum="FE3F26CFB83CC2EB" modified="2021-06-02" version="1">MSAVNPRPRAGNRRDEAARLAVLHAADDLLVEHGFAGLTVEAIARRAGVAKQTIYRWWPSKVEILLDTLIADSEKRVPVPTAPATADVVLGYFRDFARFVVDDPAGRVLLTLVAQAQHDTSAAESFRTRYLAPRRERERDLLARAVDAGAISPRLDLDATLDALIGPVVYRALTGAGGSDDLVTALGEDLLGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV57</accession>
    <name>A0A7W7WV57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="5">3.4.13.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="138"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="37874" checksum="9D229F9F7EFE1627" modified="2021-06-02" version="1">MPYSTRRAALRATLRDRDLDALLVTNLLNVRYLTGFTGSNGALLVSADSDTSTVFCTDGRYTTQSAHQVPDLERLIERPCDVALVKRAGRVRLGYESGHVTVEGLDALTGAADGAELRRAPGVVEELRLVKDDTEIEALRMACAAADRALAGLIEHGGLRAGRTEREIARDLENLMRDHGADGPSFESIVAAGPNSAVPHHRPTDAVVRPGDLVKLDFGALVGGYHSDMTRTLVVGRADDWQRELYDLVASAQTAGRAALVPGTALADVDAASRDVIDRAGHGEHFLHGLGHGVGLEIHEAPALSKAGAGTLLPGMAVTVEPGVYLAGKGGVRIEDTLVVRQGAPELLTLTTKELVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC6</accession>
    <name>A0A7W7WVC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="146"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35655" checksum="065055EBFC75E5C8" modified="2021-06-02" version="1">MEAVNCCLPVTEDVVWVRVEEAAESGRVRRLATNLAERLAFPPTRAAEVGLAVTEIGTNLHRHAVEGQVVLRSVRGADRAVIEVLALDRGPGIVDLDLALADGQSTTGTLGVGLGAVRRLADDFAITSRRDRGTILSARFRPERRDADDDVSASGLTRPLGGEEVCGDAYAVRTAPDRLTLMMCDGSGHGPLAATAAREAVRVFCAEPASAPEEMVARLHAALRGTRGGAVAVADLDLVRRTVRFAGLGNIAASVLADGRKRGMVSVPGVAGYQARTIRAFDHELPPGARVVLHSDGLTERWTFDPELVTLPPLLAAASLLRDAGVRRDDASVLVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW24</accession>
    <name>A0A7W7WW24_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A thioesterase PaaI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16273" checksum="2AD0400683E5D32D" modified="2021-06-02" version="1">MSSIQERLYPTLPCFGCGHANERGLRLRSHEGDDGVVTATFTPWPEHDNGLGFLNGGIIGTLLDCHSAAAVMLEADKRGWAALGGAALPYVTAGLDVRYLRPAPLTEPVELRATVAAAAEPEITAAVELWWDGKVRARADALWKRWRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB3</accession>
    <name>A0A7W7WWB3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031295545" evidence="2">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22033" checksum="C0DB8FE9897498AE" modified="2021-06-02" version="1">MSTRNRTLLALPLAMAAFLGLAAPAQATPGITCHTAGVDPTAKIRYRTETLIKAPLSTIWRLQTDVAHWPTWQKPVTSSKRLDHGPLRPGSRFRWTTPAPATPNTPETTLVITSTVRQLQHSRCIRWTGPAMGEGLTIDQGVHVWNFVPTKNGVLVRTEETWTGAQVEADVDLSTYYLGEGLKLWLSDLKTTAESRHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL5</accession>
    <name>A0A7W7WWL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="790" mass="86301" checksum="5BBA045024696DA2" modified="2021-06-02" version="1">MVGSPGGDFGELAAFAEEVRAAVEPVPDHPEVGEERERVLGLARALGDRVGCEVAFGVFAESSAGKSLLLGALVGNPSLLPVETRTVTCNITELRLRHAAVRVARVVAARAEYLDHDEIRDYIDHLVRHTGNLVRAADGDVGALRELTPDWSGLFRLRQVLDSSARLRLAPNALDDLRREVDEMLKGERALRASGLAPGSTEELLTPDGVVDTAALWALVDHGTAAGPADRQAVVRRVVAEVEVPAGVWSSARLYGAAVRLVDVPGSRGSRKPVRDEYLRVRELDEVDTALFFLDSRPGSTHESRALQDLMIAGRRDLDRARDAILVVAGKFDAVPEVPGVLLDEPRVEPEEEAVLGRSAVLRELVTAARDLVPSGRDDRIFFVSPYVTMANAGELDLGWDVDGEIARLRAGQEVALARDKVERWRRVGRVPGRLGDGLAAFTTDGGLDALRTGMIRHAAEHGVTQALDRVRTQADELRSAFERLKRRRADLGPVPVEDDDVRRLVERVFGTIRDRVAQARSALSQRLADPESAPRTGKAPAERVREEAERTVADWPEWKALFDAVADGRVQADSATDLPEEYRDLLDDAPLPVLVSEFSVLFRKACDRVDAGHPDVVAERVETYLDECGLVTQAERELIDEVLTPAVRARLGAERGGGALLVAVGQFTRPHETARDVCARLKVESEAGDRHFPLDPTRALPWHPDSPRRGSESYTGIGQVLRLRQSMTEAVVVQCRGTLAVALAAAAKELDGKFRGMSAALNLINNNAVRWIDEITRARRTDGSEETDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU5</accession>
    <name>A0A7W7WWU5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="8904" checksum="A5278DF96F84676F" modified="2021-06-02" version="1">MNGIVRGAGAAVVVGEGAAEATVVAARRVVADVRVRGHARLVAGGRGRPGRTGRWCGRGVDDDRPPGGRGAGAVQDGRAERDHDDPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX25</accession>
    <name>A0A7W7WX25_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15632" checksum="0F1F8EE769AD1942" modified="2021-06-02" version="1">MADRLGFTLARLGLSVSARLHTAMAVTGLKPRQCLAVMRLAEGPLNQLDLARELDVDPSVLVAVLNDLENRDLATRRRAPEDRRRHIVEITERGRAVVADLHHAIDTVEHDLFADLAPADLTRLAGLLDRLGKTEDAPCSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP8</accession>
    <name>A0A7W7WXP8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030775144" evidence="2">
        <location>
            <begin position="28"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="82"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="533" mass="55563" checksum="828BD2B13864019F" modified="2021-06-02" version="1">MTRLRAAVLVTTTALLAAGCAATPAPETESKDQPPKTGGTLTFATDADPGCLDPHQSPLAASQLVTRGVVDSLTAQDPTSLEIRPWLAEKWTANPDATAFTFTLLSGVTFSDGTPLDAAAVKANFDRIVDPATKSLLAAGLLAGYAGTTVDDPRTVTVKFSAPNASFPQAASTAFLGIQSPAAFAAGPEALCRKPVGSGPFTVGERAAQQDITLTKRENYGWGPETAKNRGAAYLDQVTIKVVPENGVRTGSVRTGQVDAVANVPPKDVDALKAAGVEVAAKAQPGIAYSINLNGNRAPFTDVKVRQAIAKAVDTDQLVNALYQGKYPRAKSVLTNATPGYAEVLGTAQFDQAGANRLLDEAGWTRQADGVRAKDGNPLAVEWAYVSPAREQRDLLAQAVQQQLKAVGVDVKLTPLPAGEVVAKGARGEWQVGDISFVRADGDVLRTVLTAPRVGAPAVVAPEVPGLLSAAASTVDQGVRSTNYGKVQRSIVELATSVPVYDPTYLLGTGKAVHDLGFDPQGLPAFHQAWVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR7</accession>
    <name>A0A7W7WXR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase-3 subunit epsilon</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="567" mass="61342" checksum="3B6FF5DDAC755225" modified="2021-06-02" version="1">MTTQLSFDELGTPLRDTTFVVFDLETTGGSATEDAITEIGAVKVRGGRVLGEFGTLVDPRRGIPPQVVALTGITQAMVSAAPALDAVLPAFLEFVGDAVLVAHNSGFDVGFLKAACERHGYRRPTSSVVCTVKLARRVLTRDEAPSCRLSALSALFGVAEMPNHRALTDARATVEVLHRLLERVGNQGVHSLEELLAYLPDVSPAQRRKRSLAADLPAEPGVYLFRGPSDEVLYVGTASDLRRRVRQYFTASEGRRRVREMVALAVRVDSVVCAHALEASVRELRLLTAYKPAYNRRSKNASAAWWLTLTDEAFPRLSLVRTPRPGALGPFRTRRSAENALDAVLDAVPLRACNQRIPASGGSGTPCALYGMGRCKAPCAGLQDVTDYEPAATTFRELVSGRTTAPLHDVATALEDLSAAERFEEAGTRRDRLAALIRVLDRGQRLAALAALPELVVARPDGEYGWEFAVVRHGRLASAGVARRGVAPMPVVAALVASAETVVPRPGPLFGTPPEEVALVLRWIDRPGSRLVHCDTPWASPARAAATWRSWAERAEAGRDLYRHAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY21</accession>
    <name>A0A7W7WY21_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">F4559_005116</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4967757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39758" checksum="7D9D1384DC975857" modified="2021-06-02" version="1">MTTALPFTRTSNQQPATPERVAEVLAKPGFGQHFTDHMVTIRWNREQGWHDARVEPYHSLELDPAANVLHYGQAIFEGLKAYRRPDGSIASFRPLANAERLRASARRLAMPELPDELFVDSIRELLAVDARWVPSNAEESLYLRPFVIATEKGLGVRPAAEYLYVLIASPAGPYFAGGVKPVTVWLSNEYVRAAPGGTGAAKFAGNYAASLVAQAQAADKGCDQVVWLDAVERRWVEEMGGMNLFFVFSSGADAKVVTPELSGALLPGITRRSLLQLAADLGYGVEERRISTEEWEKKAGSGELTEVFACGTAAVITPVGHVKHADGEFSVSGGVTGEVTLKLREKLTSIQQGTVEDPHGWMVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB2</accession>
    <name>A0A7W7WYB2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="7136" checksum="02B24478A16DAC7D" modified="2021-06-02" version="1">MSDENAWYYCLTHGKAERGVGCRGGDRMGPYPDEATARDALELARRRTESEDKRDKEWNRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE6</accession>
    <name>A0A7W7WYE6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_005719</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="47"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="253"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="276"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="544" mass="56646" checksum="D8BBB096C86BFDB4" modified="2021-06-02" version="1">MNRDRLSALMRRATDGFKAFTPGQRVVAIASVIAVLVGVVLFTGWASTPNYSPLFTNLASKDAAAIVEQLDAAGTSYELADGGQTVMVPKEQVYQLRIQLSADGLPAQDDTGYALLDQQGVTTSEFMQQVGYQRAMEGELANTIKSINGVETATVHLVIPKKDVFSDDSSKPTAAVMVDTASGKDLSADQVQAIVHLVASSVEGLDPDDITVADSTGTVLAAPGGASTGGSGNQNQQTVAFEQRLSSSLQSLLTQVVGTNHAMVKVTADLDFDQSETKTQTYTSDPNTAPLSESTTEETYTGTGTGQNGTGVLGQINGSDSSATGTNGNGSYQQKSTVRDNAVGTVIETRQSAPGKIRKLGVAVLLDEKAAGSVDMAAVKELAASAIGVDTTRGDTLAVTAMPFDQTDAEQAAKDTASASASQQQDDLVSLIKTGAAVLGVVVLLIGTWIATRKRRKRAAANAEELRVLAELQAELERNRLEAGATQGALESGGVAGALGPGSGPRQDSDEVREQKLKEIEALVDDQPDEVARLLRGWLSGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG5</accession>
    <name>A0A7W7WYG5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25494" checksum="EED055A7F737133F" modified="2021-06-02" version="1">MFRKIMDSTRRTTVAEPGWQVGLVWVVFPLLGAALLFGVELISGWVAALEWAPAQGIFRLISSIPSPWDTVAALGAGVLGGLFISLLAAVERLRVEVADDHVELARDDHDHAYDRGAISGVFVEGKQLVLLGVDGGELARETSDLRASDLEEAFRAHGYPWLPGDPHAAEYRRWIEGVPGLPVGAEPLLKARSRALRDDKKDDAADLRAELARLGVVVRDEKKRQFWRTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL1</accession>
    <name>A0A7W7WYL1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031121976" evidence="3">
        <location>
            <begin position="30"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="7">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4" evidence="4">
        <location>
            <begin position="201"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M4_C" evidence="5">
        <location>
            <begin position="349"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="6">
        <location>
            <begin position="690"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1159" mass="119118" checksum="2928B4F8F8ED2117" modified="2021-06-02" version="1">MKHKTMTAGLALAVLAGTAFSVVSGSAAAAEPQQPKPDARTLAVAAADVAASSGLDALVKGPGETYSRDLVTPYLNDLYSVSYQRSYRGLAVVGGDATVLADGQGRVKAVLGATKTKVQLPSTNAKVGKADAEKASRALQGKTEKVESSRLVVKFVGDTPRLAWEHVLVGTTKDNGPSHLNVWVDADSGAVLDKVEDAAHGTANGEWNGTVPIDTDNTGSTYRLSNQTKRPGLQCADYSTGTVFSKSTDTFGNGSETSKETGCAELMYAAQKEFDMLRDWLGRNGHTGSGGSWPAKVGLDQQNAYWDGSSITIGKNAAGKWISSMDVVGHEYGHGLDQNTPGGTSSEAGLGEATGDIFGALTEAYTNNPKDTPDYLVGETINLTGSGPIRNMYNPSLVSNDPNCYSSSIPNTEVHKAAGPLNHWFYLLAEGTNPGGGKPTSPTCNNTTLTGVGIKDAGRVFYGGMLLKTSGMTHKKYRIATLTAAKTLDPSCTLYNRTKAAWDAISLPAQSGEPTSCTPSGNNDFSLSLNPSSGSINKGASGTFSVATQTTSGSAQNVSLSASGQPSGVTVSFSPSSVQSGASSTATVSVGSSVADGTYTITVNGQGSLSHTATYTLTVGGGNPGTGNPPNIDVTAVQAHLTQFQSFGSNRRAGSSGYTQSVAYVKQKLQAAGFQVSEQTCSSCTYVSNNLIADWPGGDTAQTIMFGAHLDSVSAGPGINDNGSGSAALLENALQLAAKNPTMLKHVRFAWWTDEEQGLNGSKYYVSQLSSTARSQIKAYYNFDMVASKNGGYFINNIGTAAAAPLKAYWDSLSLQPEENVEGAGRSDDYSFQNAGIPSSGYATGASARKTSAQATKWGGTANSAYDSCYHSACDTTSNINATALDRSADGIAYTIWKQAVGNSTPTNDFSVSVNPGSGTVQPGGSATVAVATQTTAGQAQTVNLSATGTPNGVTVTFNPSSVQTGGSSTATINVGASTAPGSYTLTISGVGSATRSANYTLNVGGSSGCTASDVVRNGGFENGASPWTVTSGVIDSQAAQPAHGGTYKAWLNGRGSTLTDSAAQTVTIPAGCSNSVLTYWLHIDTAENEQVAYDTLTVKVGGATVASYSNLDSNSGYTQVSLNVGQYAGQSVSISFVGVEDASLQTSFVIDDVALTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ0</accession>
    <name>A0A7W7WYQ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="28997" checksum="B027CE7AF040A0A7" modified="2021-06-02" version="1">MDRPPFTCLMDNPGAMVGEDLELVITAVVAADGAARARAACARLLDRVGGRVLRVGDCSDEEPGCWSLTLAIDSGQRVPENVAAGLARAVRGFVRDLGFPAPRISCEPPTAWTVLDDPDVLDPLVPGAERLLVEAWAGGDPQYREPEPAAEPDVGPQPEPGTRLLLRVDVATDRAAGAEWQARAVASRVARSGKITRVAPRGDLLSVHVDLGTSIDPPAVALLDAVASLGRPGWSAPTREGESTVVRWSATPVPTGGIAALELTATPASAFVWTEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS5</accession>
    <name>A0A7W7WYS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="485" mass="50532" checksum="2EC000F4E1714755" modified="2021-06-02" version="1">MTPDQPPRRYPWEDDEYRPRARSYPVVPAEQAPPPPPPAAPPRKITVTRVAVWRVRQLTGRAWAAFRRAAHADGAQRSGQSALTYAVMLNYAADAAMAVALANTLFFSAATGESQGRVALYLLVTVAPFALVAPVIGPALDRLRQGRRAALAASCVLRIFLSIVMAVDFDGWGLYPAALGSMVLSKSFTVLKAAMTPRVVPPGITLAKVNARMTVFGLAAGGVFGAVAAGCAKVFGSPGALWFTAVLCLANAWLCLRMPPWVEVADGEVPTSLRARTKRPRQVLGRTVVVALWGNGSIRMLTGFLMLFSAFVVRAQTEGEPVLQVLLLGVIAGAAGIGSFLGNAVGARIHVGAPDQVVVWCAGAALAAVVVAAILPGLGTAAIVGLVGAAASSLAKISLDAVVQDDLPEESRASAFGRSETVLQLAWVFGGALGVLLPTEYWIGFTVLSGLLAVGLAQTIATRRGTSLLPGLGGDRPLRPTPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT6</accession>
    <name>A0A7W7WYT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11967" checksum="558D90F77EA2607E" modified="2021-06-02" version="1">MELAQVLDNALRKAAALWVRPAGHPPRLVWALWRDGAVHVAVGGTGQVVPGLADGVDCTLTVRSPTTHSHLVDVTATARLVDPDDDTAAALRSARLNGRPDWDSVYRWDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ50</accession>
    <name>A0A7W7WZ50_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="5">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031548623" evidence="3">
        <location>
            <begin position="29"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="37"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="567" mass="59537" checksum="BC2543A06F1E5597" modified="2021-06-02" version="1">MLRVLTVALVVTALVSPPAAGQPPRPQAVTSLLAGMTLEQKVGQLFVTYVNGQRADEEHPDNVRDFGVATPAEIVAKYRPGGVIYFDNDLHDNIDSPRQIAGLSRGLQRASKIPLAISTDQEMGLVTRIGPPVTQFPGNMALGAGRSTTDAEQAATITARELRALGVNQDFAPDADVNSNPANPVIGVRSYSGDPKLAAEFTAAQVRGYQQRFLTWSGVAATAKHFPGHGDTATDSHTSLPVVDRTVEQWREMDAPPFRAAIAAGVDSIMTAHILMPRIDPSGEPATLSKPVIDLLRGELGYDGVVITDALDMAGVRQKHPDARIPVLALKAGVDQLLMPPKLGEAITAVVDAVKSGELTERRIDQSVLRVLRMKFLRGILTSPPVDPDKADAAVGTPENLAAARTITDRTTTAVRNDGGVLPRRPKAALVTGWGENSTRTLAKLLGGKALPTGATPTPEQITGAVEAAGAADLVVVLTSGLSGSPEQQALVDRLVATGRPVVGVAVRNPYDVAYTSVPVWLATYSYGAGALESVAKVITGEIGPKGLLPVAVPGPTPYPLGHGLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZD7</accession>
    <name>A0A7W7WZD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031434967" evidence="1">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="31"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="36027" checksum="0BC8499EE0E969A3" modified="2021-06-02" version="1">MRALVAVLVLALLALCAPAAGVASAHPRLRFDLQAHRGGIGLTVESTLAAFAKALEVGVTTLELDVQITRDGREVVTHDRKTNPAKCLDTAPAFPGDPAFPYGGKYVKDLTFAQVRTLDCGSTRWSQYPDQQLSPGARMPTLAEVFALARAYRAHDIRFNIETKVEAAAPHETAPREQFVEITRREVLKSGFLRNVTIQSFDWTTLRLWRQTDPRFALVALTQPEFFVPGSPWTGGLNPDDFGGSPARAAKTLGVTTVSPVHTMTTRALVDDAHALKLKVVPWTVDDPAVMHRLIDLGIDGLITDYPDRLRDVLREQGFALPKRHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZL0</accession>
    <name>A0A7W7WZL0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S Wbl-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13901" checksum="C9FE5D2EA72AB205" modified="2021-06-02" version="1">MIERHRPPSVGRHNLHPHSLGFNNANPLEPAYAALLLALFGGNGRAPDWHAQAACRDTDPEAFFTPNTTAATSVCAGCPVADLCLKDQLRWESADRAVNRYTVVGVFGGVDGPGRRALHKPKRRHRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZM2</accession>
    <name>A0A7W7WZM2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (Sigma-E family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="132"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="20920" checksum="4C4BB90BEDEF4247" modified="2021-06-02" version="1">MVGPEQNNGVARVQSTLTNLRIQDGAAPQPTGPLTLEDLYKQHRMRLVRLALLLVDEPATAEDVVQEAFTGLHRNWSNLRDAQAAVGYLRTAVVNGSRSVLRRRKTARDYTPPHVANARSAESLAMLTAEHQAVVAALSKLPPRQREVLVLRYYGDLSEAEIAEATGISKGTVKSTASRALDALQKLMSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY43</accession>
    <name>A0A7W7SY43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall-associated NlpC family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="278"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="38571" checksum="F5B3BE0CB5F6954D" modified="2021-06-02" version="1">MDVGGFLAGLVQPMKDHLAKLDGDIGGATRAAESFGKASSALTEIDGRHTGAANAALGTWYGEKANAFQARVSTFSGGVRTLARNATTIQNGATAAAQAVGTGRATIQGLIDEFVGWAQPRLAAAIGATLFGGLGPALAMAAVITSVARDYEARSAQELERVRTELTNVVTQLQGLQPANFAGVGDPLGVEGGGTTTASSSIETPGRDPQQPGSVGSSSGSSSGSGGGGGGGGGGGGGGGGGGGGGASGPRLPVAIPPQPGTGVGVNLPDGSSAEAPNETAARAVRNALSALGTPYVWGGANPPQGTDCSGLTQWAYKNAGFDIPRPASSQAMGASVPPNQLLPGDLVVWDGHVAMVIGNGQMVEAGDPVQVNPIRTDNIGMGFLGFYRPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY85</accession>
    <name>A0A7W7SY85_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ORF">F4559_000463</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="249"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="400"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="487" mass="52856" checksum="E2909EF9DF98CFC0" modified="2021-06-02" version="1">MDATRYVAALDQGTTSTRCIVFDHAGRVVSVDQREHEQIMPRAGWVEHDPTEILRNARAVVEGAVAKAGLEAKDFAALGITNQRETAVVWDRASGEPVYNAIVWQDTRTDKICAALGDHDTFRAKTGLPPATYFSGPKIKWILDHVGRDRDVLVGTIDTWLLWNLAGVHATDPTNASRTLLMDLDTLAWDPDLAAALDVPLSVLPEIRSSSEVFGHLRDGVLAGVPIAGMLGDQQAATFGQACLSPGEAKNTYGTGNFVLLNTGTEKVVSHNGLLTTVCYQLGGQDPVYALEGSIAVTGSLVQWLRDNLGIISSAAEIEEHARTVEDNGGVYFVPAFSGLFAPYWRSDARGVIVGLTRFVNRGHLARAVLESTAYQTREVIDAMNADSGVGLTSLKVDGGMVVNELLMQFQADILGVPTIRPVVNETTALGAAYAAGLAVGHWESEDDVRANWAQDKRWDPMLDPTARESLYRTWKKAVTRTFDWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP7</accession>
    <name>A0A7W7SYP7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15692" checksum="0DC659915FC08228" modified="2021-06-02" version="1">MVDDAVVTRARPKGRLLVGRALLVLGLLVTLIGLVLVGACFKDDLAIEKRTGHVTAEVVSVSFQRTVVRFATPDGAVYSPSQGVLYPDGLEPGQLVRVEYDTANPELARVQGRTYTLALLPVGTFLLAVWAVLAVPVWWLRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR6</accession>
    <name>A0A7W7SYR6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fic_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fic_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31748" checksum="79D44EBB44FE434F" modified="2021-06-02" version="1">MCSPATYSVLAEAEHALGRLDEAAERLPGRHWFVRSTRVRDAVCSAHLSGLPVGLREAFAADLVAGQGPPPVDRYGPTRALAPYLAVPDGVDEPLTPDVPRLEAIASAHYRREVLRPFRAQEAHRARAASMRQLVDAGLLRDEVLPLSLALEEDTPEYRRQLHRVVETGEVEQWLRFFAEAVRDQALAQVRLIGRTLELIDEYARRVRRAGTLAEVAVDLAGFPVVNHRALVDRYEVSPKTATNLTRQMVELGMLVQWGGGSTYRRIYVCEDALGLVSQESPDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT2</accession>
    <name>A0A7W7SYT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21486" checksum="6993D8A096318DD2" modified="2021-06-02" version="1">MTPQRTRAGDRPRRRSLTWQMKPGTRKAWLIAHVVVSVGWFGGAWAMLMMGVVALTNVGRELRPAAYEMMHIADTVIMIPGSLGALITGLVLGLYTKWRVLHHWWVVTKLLLTIGAMVFAYVYVAQNVKSALAATEHDLDADIGRLAESVIAGSVVMMVVLIVTTLLSVVKPWNRTGWGRRAQQRRREAVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ38</accession>
    <name>A0A7W7SZ38_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_16" evidence="3">
        <location>
            <begin position="401"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1225" mass="132829" checksum="06DEECA1582BA52F" modified="2021-06-02" version="1">MTGLIVDGSGFELVLGDERIGPLRALESTDTEFLEQLTAQYVRAVHANSDSVLLELGRKLFSWLDGQQGQLRTWLERATAPEVLEVRGPQWPSHTAWAVLRAPFELLAWPDGSFLAGEGLTRFCVARRLGSPLQPATPDGFRLGLAFMASSPMGQHELDFEAEETAILDAVGDARVDLLVEDTGDPEQLGERLSDAGLPVVHLSCHGLNAWPGKGGEPVLLMEDSTGGPRPTTASELVGHLPKDTRLVFVSACLTATGADDSTRLPAGTERKGGPGPGGRPELLAHSLSTSLVSAGVPAVIGWDGSVNDRAATKFAEHLYRALTNRTDLAVAVGDARRALLDSDDPVVRADWHMARLWLGQAGGGQVVAGRRKRSMVSAVHGTKRFLDQKSQVPVAKAQMFVGRRDELRRALRALRDGEHAGVLLQGQGRLGKSSLAARIVDRTAGDYAVAVVFGDYGASAILNAIRDAVRTDQKARELIDAGIARVRDRPEAIGEVLIDLLSGPCAQAGDGHKPLLLVIDDLEQILASNAAGPHRVVPEHALVLAAVLRAFEPAETDSRLLLTSRFVFTLDGAENTLERIQLRPLSTVAQRKLHRRHQALAPADRQDKRADLAQRAVTASRGNPGLQDLICLRLVYNDQVPLSRAEAAVSQMEDYLRQGDLPSDGEVREFLENLALDALLDEAGTPARALLRAVTLFDLPVPEPVVEILADHVGGTPTRLRDLGLLEPYPDPHGTGGTALAANPLAAGRIPPLSTAERSTLAAITVEVLLAAWTPDTESQGRTTEQDLQLTRLSLAADNPSVTATCAAGAVTHLRAGVAAEASTLGHDAISLLDRHHRSVPVLLLRVTADAALTSGDGTLGHALLDRAVRQTATENHEDPLERARVLAERARRILTTGDLRQAEQLIHQAHALFTAKESDGEAAAATGVLGDILFQRGDYDEALRIRRDIELPVYERLGDTHATAVTWGQIGDILFRRGDYDEALRIRRDIELPVYERLGDTHATAVTWGQIGDIAERRGDYDEALRIRREVQLPVYERLGDTHATAVTWGQIGDILFQRGDYDEALRIRRDIELPVYERLGDTHATAVTWGQIGDILFRRGDYDEATRLQLKRLEVHTRLGDLDGIAGANWDLARLNLSQQDHESAAPRLIESYSINRRLQRAEGIAVVGTTLAQLLAAAGETVQARQIADESLQAATKIENQALVEQLNSLIDRLDQGNEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ9</accession>
    <name>A0A7W7SZJ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11560" checksum="221887253CDADF16" modified="2021-06-02" version="1">MDKRLSRDSVELLRVEVLHTRPDGTPADPTIYPVAVAVTPADVRYVLSTDFKPAQWQHGPAGPVAVVLVGTGSDVGTLALGRNAVWVRVQADPEIPVMRADMTLVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T039</accession>
    <name>A0A7W7T039_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 11">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">murC</name>
        <name evidence="15" type="ORF">F4559_001463</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="14">
        <location>
            <begin position="113"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="13">
        <location>
            <begin position="316"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="115"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="462" mass="47439" checksum="FDB8093B2FF5ACC9" modified="2021-06-02" version="1">MSVLDRVHLVGIGGAGMSGIARILLARGARVSGSDAKDSRTVLALRAQGAAIAVGHAAANLDQFDGGPTAIVVSTAIRDDNPELVAARARDVVVLRRAEALAALMLDHRVACVAGTHGKTSTTSMLTVALQHCRLDPSFAIGGDLNESGANAHQGTGGVFVAEADESDGSFLFFSPTVAVVTNVEADHLDHHGTVEAYIAVFDSFLERIDPQGVLIACVDDPGAAALADRATQRGLRVRTYGRAATGPGAATLVDYKPADGGGLAVVYIDGETVDVRVAVPGEHMAANAIAALIAALELGADRAGVLEGLAAFGGVRRRFEFKGRAGGVRVYDDYAHHPTEVSAQLAAARPVAGDGKLVVVFQPHLYSRTRLFAAEFGAALGLADQVVVLDVYGAREDPEPGVTGALVAGAVPLDDGFVHYEPSFDRVPALVAGLVADGDLVVTMGAGDVTILGPEIVDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T054</accession>
    <name>A0A7W7T054_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Homoserine kinase</fullName>
            <shortName evidence="10">HK</shortName>
            <shortName evidence="10">HSK</shortName>
            <ecNumber evidence="4 10">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrB</name>
        <name evidence="12" type="ORF">F4559_000926</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="29565" checksum="E193D11EFE618DBF" modified="2021-06-02" version="1">MTGFRVSVPASTANLGSGFDALGMALGLRDELEFEARADGLVVEVSGEGATVPTDESHLVVRAFREACAQVDVKVSGLRLRCRNAIPHSRGLGSSAAAVVAGVAAAYAFAGRELDTDALQLAAEFEGHADNAAAGMFGGVVVAWTVGTRYRFARLDPHPDVRPVVLVPDVESSTKTTRGLLPATVPHADAAFAAGRSALAVHALTRDPALLVEALDDRLHEPYRQPAWPATSALVTALRAAGVAAAVSGAGPTVLALPEGGVLPAGVDTSGFATRPLPVDLAGVTVAPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T072</accession>
    <name>A0A7W7T072_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27230" checksum="B3C69697B1C108E6" modified="2021-06-02" version="1">MTDEPPRSPQQPDIDPEQLRQFQEFQRFQEFQRFQQAQGQHALPPSSQPAGAQPPVPLPPDPKPAKAPGKPLWRVLVGSRLFRRLVSLVLVLLVLSYFYERFFGTDDVGDVAVDSGGDKGNVIAPQTPWGIQGTVAMFYKHVITDDAGRACALFSEDRAEKSFADAFGAQDCAAAVHALNKQVTNEADYRQVGFPAEMRGTPKGAGVEVSSCALQVTGGPRLGRFVLTRQVNNTWVISGYEAEPADCATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C7</accession>
    <name>A0A7W7T0C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="5">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18351" checksum="A57E427BBE0F0090" modified="2021-06-02" version="1">METESRQVAAGDAFDEFFRADFARLIAYLGKLGFRREDAEDAAEEAMTILYTRWSQVEHPGAWVRSAARRCASRFARREQERGAREALGGTLGHDGAHHVEEVLWLTDELARLPTRERDVVALRVEGFSAAEIATILAVRPATVRSHLRNARKRLLTCTGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0F6</accession>
    <name>A0A7W7T0F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Superfamily II DNA/RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="269"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="485" mass="52262" checksum="2706FBF0695BE32D" modified="2021-06-02" version="1">MPSTSQGRSERSQSRRPRRRTGQGDRRPRQHVEPVVATTVPDHVESTLPEGPLPSFSELGLADELVAALTKAGITEPFPIQAATLPDTLAGRDVLGRGQTGSGKTLAFGLALLSRLSSGRARPLKPRGLVLVPTRELAMQVEEALSPFARALGLWCRTVVGGTSFPRQTDALRRGVDLLIATPGRLSDHVRQGTADLSEVMFTALDEADQMADMGFMPQVRAILDLTPRDGQRLLFSATLDGDVDKLVRQYLHDPIVHSVAPPTGSVTTMEHHLLFVSAEDKQSVVTEVAAREGRTIMFVRTKHHVDRLAKKLRAMGVHAGALHGGKAQSARTRVLGQFREGTTPVLIATDVAARGIHVDDVSLVVHVDPPADPKDYLHRAGRTARAGQSGTVVTLVTHDQRRAVQGLTARAGIRPASTKVRPGDDELVRITGARVPSGVPVTEPEVPVRAARRGGGTPGRRSGPFRGAPRGDRERRPRRSAPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H2</accession>
    <name>A0A7W7T0H2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22001" checksum="D31373288ECB4906" modified="2021-06-02" version="1">MTSPDPHSNPYGVPAQPDPAQQQYGQPQYTQPYEPQPQPQPQPQYNQVYTPAQGGQLVPTEQPNPYATPAQGTPYGAYAQPRPQPQQQPRRKPPILVLSIVAAVLAVVAGVFTVLYVTKNGELGDTTAARAGKDGELAGVKDDQAKADKGLSDNKSKESSLKDEHDLLTQCVDATKAYFALPAGQTPESSRLFRIMYDICPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K4</accession>
    <name>A0A7W7T0K4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="15" type="ORF">F4559_001659</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="312"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="650"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="894" mass="97548" checksum="1AFB527286D64DB7" modified="2021-06-02" version="1">MSTPADTTGASRLLLVDGHSMAYRAYFALPKENFRTATGQTTNAVYGFTSMLINLLRDEKPTHVAVAFDVSRRTFRTEAYADYKAGRSETPDDFRGQVSLIQDVLATLSIPTVSKENYEADDLIATLTTQATALDYEVLICTGDRDALQLVTDRVTVLYPVKGVSELARYTPALVLEKQGVTPDRYADYAAVRGDSSDNLPNTPGVGPKTIVKLLTEYGSLGGLVDRVDEVKGKVGEALRANLPNILLNRQLTELVRDVELPLGPVELEAKPWDRDAVHRLFDELEFRVLRDRLFATLSTAEPEAEEGFEVSGGAIEPGGVAAWLDEHARSGRVGLSFRHTGVDLEGLALASGGVGGYAATATLTPADEAALSAWLADPAVPKAAHDLKLPLRAVRARGWTLRGVTSDTALAAYLVRPGQRSFALDDLALRYLKRELRAEESDDGQLSLLADEEEERQKIATGAILRAFAVAELADALDGELRDTGQAELLAGLELPLEVVLDEVEAVGIAIDSTRLASLEAHFAAGVKQAAQDAYAVIGKEINLGSPKQLQAVLFDELDMPKTKKTKTGYTTDADALQNLFEQTGHPFLQYLLAHRDVTRLKSTVDGLLKAVADDGRIHTTFHQTIAATGRLSSTDPNLQNIPIRTDEGRRIRQAFVVGPGYAELMTADYSQIEMRIMAHLSGDEGLIEAFRSGEDLHTFVASRAFSVPTAEVTAEQRRRVKAMSYGLAYGLSVYGLAQQLRISAAEATEQMEAYFSRFGGVRDYLHTIVEDARHKGYTETILGRRRYLPDLTSDNRQRREMAERMALNAPIQGSAADIVKVAMLGVFRALEESGLRSRMLLQVHDELVLEIADGEREAVEELVRAHMGGAYELSVPLEVSVGVGRSWDDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W6</accession>
    <name>A0A7W7T0W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14738" checksum="76BC31ED0C3D2909" modified="2021-06-02" version="1">MSGIMSRWAVQRDHAVEGAVTAEQVERWIDDACTTYLDLCPLLTTYDVRRAVLAIPDPGLFGTPNEMTVTASATEVRPGAFTLSVRLRPFGGGNDTPANVTCVVTLTDPETGAQRPVGDDIRDQLIAIEHGARHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T109</accession>
    <name>A0A7W7T109_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17599" checksum="5E53097BBE32E842" modified="2021-06-02" version="1">MEDHKNVQRNLALQREWYGEPLGDRVRRLVVAFNVSQAQLADVLGISAPMLSQVMSGRRAKIGNPSVLARMIMLERKVLTPDVSTGAPEALQRALDEVRESKPTVSRDSLPLASADDEARVFDFLRRAADRHELGQAADVLGEDFPALSELLRRAGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T178</accession>
    <name>A0A7W7T178_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_001541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="3"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="355"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="51094" checksum="D0BEDAF1CA662B02" modified="2021-06-02" version="1">MSRRAKIVCTLGPATATEDKVNELVAAGMDVARMNFSHGSHADHKQVYDLVRAAADRTGRAVGILADLQGPKIRLGRFAHGPVEWRTGDIVRVTVEDVQGTHDRVSTTYKQLANDAKVGDRLLVDDGKVGLVVTAIEGPDVVCEVTEGGPVSNNKGLSLPNMDISVPALSDKDIEDLEFALHLGVDFIALSFVRSPADIDLVHQIMDRVGRGRRPVIAKIEKPEAVDNLEAIVLAFDGVMVARGDLGVELPLEHVPLVQKRAIQIARENAKPVIVATQMLDSMISNSRPTRAETSDVANAVLDGADALMLSGETSVGRYAIESVKVMGRIIEAVETESVEVPPLTHVPRTKRGVISYAARDIGERLNAKALVAFTQSGDTVRRLARLHTPLPLLAFTPEQSVRSQLALTWGTETFLVPKVDSTDEMVRQVDSSMLSIGRYQPGDLMVVVAGSPPGTVGSTNLIRVHRLGEEDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T184</accession>
    <name>A0A7W7T184_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015103570.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045745">
        <property type="entry name" value="HTH_58_Actinobacteria-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19575">
        <property type="entry name" value="HTH_58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_58" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7449" checksum="D09C1BF3C7E3AB24" modified="2021-06-02" version="1">MADLKKGARITGATRDKLAADLKKKYEKGASIRALAESTGRSYGFVHRVLSESGVQLRGRGGATRTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1I9</accession>
    <name>A0A7W7T1I9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase-like protein</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="18287" checksum="AB1AA884E2AE928C" modified="2021-06-02" version="1">MAAVVAAHRDELVELDRVIGDGDHGENLRRGFAAAVSTVDGSGPVLRQVATLLISKVGGAAGPLYGTGFLRAAGAVEGRPLDGFVVASALAAALEGVVALGKAAVGDKTMVDALAPAVAAAESAAASGGSVAAVLEAAAVAAAEGAASTVPLVARKGRAAYLGARSAGHLDPGARSTALVLRAFADAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U9</accession>
    <name>A0A7W7T1U9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="53EXOc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="32423" checksum="566EAFDBA5AE38B5" modified="2021-06-02" version="1">MDAASLYFRAFYALPDSMTAPDGTPVNAVRGFLDTITKVVADRHASRVVACLDADWRPEFRVAALPSYKAHRVAADQDGEEDVPDTLTPQVPIILDVLDAVGIATAEAAGYEADDVIGTLAHRERTDPVEVLTGDRDLFQVVRDEPTAVKVLYLGRGWAKAELLGPAELAAKYALPTTDTGAAYAALALLRGDPSDGLPGVAGIGEKTAAKLITEFGSLDALLAAVHDGRDRKLTTRARTALIEAEDYLAKAPTVVNVATDAPIVQDRPDQVPAAPVDPDRVADLGRRWGLGSSLPRLLNALERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T286</accession>
    <name>A0A7W7T286_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="44674" checksum="92B05992ED62989A" modified="2021-06-02" version="1">MDLFQHGHADLRALRENAPVHRDERTGLWLVSRYANVRAVLADPKTFHPDNALTAITPIPRPVLRTLARSGFSLPPTLANNGTPTHAPLRRLVARYLTPVRVAAMSDRIVELTRERLDRLTGPRVDLHPALARDLPAIVLLEIMGIDDVDVDALKAWSTASLELFWGDLTPDRQRALAGPAAEFHRWLSQRIRSARGDDLFGALNAAGVSVRDAAGLCYFLLIAGQETTTQLLCAVFHGVLRHGDLWSRLDEPGMAAHCVEETLRREPPVNTWRRVAARDTELAGVRIPQGAHLLLMLAGSGSDPEVFDEPERFCPARPNARKHLAFGFGPHFCLGAGLARLEGEVVLRETARRFPGLRLASTASPPMLGLLSFRAPLSVDVVLGDEDQLARGGTRFQQVVGAGGVGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Q0</accession>
    <name>A0A7W7T2Q0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="350" mass="34997" checksum="05CEF76F2964E7BD" modified="2021-06-02" version="1">MFLAWRDLKFAKGRFALMGAVIVLITLLVGLLSGLTAGLGRQNVSAITGLPVDAIAFQAGPEPSYADSAVTESQWRRWAATPGVVSAEPLGITTTKAEAGGRSTAVSAFGVRPGSALAPAGDKIDDGGAVLSVPAADALGLAPGQAFTLAGQRLTVAAVEGDASFSHTPVVWIGLATWQRTTRAEATVVALETAGADLEEGDRAAGTRTVSLADSLSAIGSYTSENGSLQLMRGFLFAISALVIGAFFTVWTIQRSGDIAVLKALGASTAYLLGDALGQAAVLLVGGTLVGTGAAAGLGALAGDSVPFVLTPATALAPAAVTILLGLLGAALSVRRITSVDPSTALGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2S8</accession>
    <name>A0A7W7T2S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="58" mass="5976" checksum="03045FE28E59019C" modified="2021-06-02" version="1">MTTDEAVAVLTDPDAGPEDRYRAHADLHALAASGDGAAGAALAWLRLERSGRNACEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T312</accession>
    <name>A0A7W7T312_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="35333" checksum="06F9BAD1204FDF5A" modified="2021-06-02" version="1">MLSPVEVLAMTPWARLEHAYGDAADLPDRLTPLLSEDSEAVARALAVLDAAVLHQGTIYSSTAPVAVFVAGILADPRTAVSCEGALPWDPRVRPVRAALLEWLAVVADSAAFEEYDDRDTLACRAVRADLVDAVLPFLDDPADPVRVAALAAAGHLLRAPELATRRTELADRLRSWAANTPPVDRVRVALTLSCWGIAPHEALTDPDPVVRAYAAISPALDTDPRALDEVRTALRDPESADAWFADEPLPHLDHRFGACLVEALLRRTATFEEVEEEAAAVARSTEKIGLTPMLERAFTPPVFTDDQLTPAQRRFRDVLDKHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J7</accession>
    <name>A0A7W7T3J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10258" checksum="2813BEF3708F99BE" modified="2021-06-02" version="1">MSRSEPGHRLVGNDLGAAIGLVQLRRLPEFVTRRRAVAARYDRLLADLPGVLTPPAPHEVPLYGSDARLPAWSRWRAVIPTARHGSRSASAVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Y4</accession>
    <name>A0A7W7T3Y4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4158 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025296">
        <property type="entry name" value="DUF4158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13700">
        <property type="entry name" value="DUF4158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4158" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16752" checksum="A7C14B45D6AE7981" modified="2021-06-02" version="1">MAVALCTLPWLGFVPDKVSVAPPVAVARLAEQLKVDPEELRSYGKRAKTRTDHLRLVAQYLSWRLPTTLELKELDEFLLARAMEPEYTAPRQSTSPAATAALALGLLPGRAVKPLGPATDGSDVRVVAIDHCWSRASTWTGPADEGRLRGRVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E0</accession>
    <name>A0A7W7T4E0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoadipate enol-lactonase</fullName>
            <ecNumber evidence="2">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.24" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="28035" checksum="45F229E389A2E5E8" modified="2021-06-02" version="1">MPSDRVPVDRGEIAYRLQGQGPPLVLLSTLSGTWVRQVPVLRRHFTLLTYDLRGFGDSPSADGFPDNAGHADDLARLLDALGFPTAAVVGLSHGGLVAQHFAGRHGDRLSGLGLVSTIAAPRRSTVLFLRMLKGFLDRDDVAGFWEVLRSFLFSAANFDKLLAREGALREAMFNQYTAGALLSIYGQALTHDATGWLGGVDCPTLVVGGREDMLFPPWQTEELAALVPGSKLVLLPAAHVPPVEVPADFNHLVVDFFGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I3</accession>
    <name>A0A7W7T4I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031478780" evidence="6">
        <location>
            <begin position="20"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="5"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="44901" checksum="F041E68B1C70EB9A" modified="2021-06-02" version="1">MRNPTLVALSLSMLLPSAAVGIANVGLPTLATAFDASFDAVQWVVIAYLLATTTAVVGAGRLGDLVGRRRLLLTGVAVFTLGTLLCGLAPTLPWLIAARAVQGVAAAAMMALTMAFVAEVVPADRTGRAMGLLGTMSAVGTAAGPSLGGVLISAFGWRMLFLAIVPLGVVGFVLAARTLPRPSMPDRPRFDLPGLVLLAVTLGAYTSAVTLDRHQVPSLLVAAVGLVAFVVVENRVAAPLVALAGLREPGLAAGLTSGAVVSAVVMTTLVVGPFHLGTALGLAPAWVGLAMSTGPVVAALAGVPAGRLTDRVGTRTAVLAGLVAMVAGSTALALLPVGAGVVGYVASLVTITAGYAVFQAANNTAVLRDVPGPRRGVVSGLLTLSRNLGLTTGASVMGAVFAATAHDVTLADQVARGTRWTFAVAAAGLVVALGISSRTRRLARTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J0</accession>
    <name>A0A7W7T4J0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="2">
        <location>
            <begin position="313"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="562" mass="61654" checksum="CB578BF8E68A648A" modified="2021-06-02" version="1">MTESLTVDRMVPIPMRDGAVLYADVYRPVARRCPTLIFRTPYDRTGLGMYGTFALRAASAGYAVVMQDTRGRGASEGVFTPFVHEREDGYDTIDWVASRSWCDGNVGMFGGSYDGVTQWQAAMSGHEALKAIAPNVTASNYHHGWVYRGGAFQLGFSLGWTLSLAAHNAARDPSVPQETREALTDALDRLPETSRVLPLSDHPYLDQVAPYYREWLRHPTYDAFWERLDVSRAHSTIDVAAFNLGGWYDTFLVGTLENFAGMRARGPVDVRDRQRLLVGPWPHEGLFRGNPVGEWNFGGRATAGALDAEGLQLRWFDRWLRGADHTDPAVLLYAMGSDEWREADSWPLPGTEYQDWYLHSGGRANTLHGDGLLSRETPGDQPPDGFRYSPHDPVPTKGGALCCNPVHLGAGVYDQRSVEERSDVLVYTSEPLDRPVDVTGPVSVVLHGSSTALSADWTAKLVDVGPCGYARNLTDGVLRTGHREPGEVAEYRIDAGATSNVFQPGHRIRVEISGGNFPHFDRNPAAGSAGSLQTVHHSAPHLSRIVLPVVPSDATRPYLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K0</accession>
    <name>A0A7W7T4K0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="12888" checksum="DF3CB0244A3497F0" modified="2021-06-02" version="1">MTILSPGRYPSAPDHDRHPGIDGRTPTARIAAGEEAASGARGFDFVSCRAAAVPDEAERTVRAAVAGHAVRVVMTGAGVRMAVEHTVSFERLVDLVVDPVPGVVFRVTTSPETTVDAVRRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K9</accession>
    <name>A0A7W7T4K9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase-3 subunit epsilon</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="39470" checksum="C9C673AC5BFF6CF7" modified="2021-06-02" version="1">MNDSTGSWGEGPLVAFDLETTATDPHRDRIVTASVVTITPRGDGPPSVRTRTWLADPGVEIPPDATAIHGISTEHARAQGRPAAEVVAEVVDHLAAVWRPDVALCVFNAVFDLTMLDAESSRHLDRPLALTGPVLDPLCVDRHLRPVRDFTDRRRLSDVCAHYGVRLEGAHTSDGDALAAARVAWKLARVHASEIGFLTLAELHDRQAAWHRAHEEEYALRLERKLTDRLARSGESEQTEEWRARVDRIREAGRHWPLTPDLGPVRPPRRSGPANANAPWTPALEAELRESWLATDPAETPETARKTLATHFARSPTAIRARLLRLGCDPEAPGRTCDPARAAELKRRYEAEYPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N1</accession>
    <name>A0A7W7T4N1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28065" checksum="B1246D8170C7A467" modified="2021-06-02" version="1">MPTAWDGYARVDYLPAPGRLQVTLHTVEPTVHRRLRDGLACAFAVDGRAGPPTYVEIDVGDGLTYDTRVLLAGPLLDIAVDLVGDGPASRETRLPPAQVAALARRWAPYRDFVLAPAPAPVRSGSWADGLWAVFGGLGLVRALRAFVPPPEPAHRGDEVAAEEHWEWLELPADLAAAAGVDRRVGWAPYRDVALDGTAETGFMIMAVPAPVARLLVGLDDGSGRWVAFAPDPETPGQVFADLPCGPDVAEPALRFRTEEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P3</accession>
    <name>A0A7W7T4P3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18907" checksum="70439456473DC2FA" modified="2021-06-02" version="1">MLLGHSGNRWRHTVGVAHRAAELAAAVPEEERDTLVAAAWLHDIGYAIPLVDTGFHPLDGARHLDRTGWRRDIADLVAHHSGARFVAREIGLEARLSVYPWEITPLSDALAYADQTVDSTGERVSLEDRLTDMLHRHGPRSANARAHAVRAPYLRGAAERVEARLPALVAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P5</accession>
    <name>A0A7W7T4P5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="448"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="520" mass="54470" checksum="CB0900B9CA349A52" modified="2021-06-02" version="1">MVRLDRLVNVLGGYGVRLCCCPVPRSAALRDVVVHDPADDRPVTGDVFLALGAESVDDAVKWAARARAVCVLVRGDAAVERDAAVLGESAGVAVLVVDPAVSLTELAGVVYGLVLEGRETESGRGPTDLFALADSLADAVGGAVVIEDRSARVLAYSSPQHDVDPARADTILHRRVPEWLGVLLDGRGVAAHLSSSDEPLFVAAEPDSGLSAGRMVVAVRSGRELLGSVWVACAAPLAGGRRSALADGARTVALHLLRSRASADLERQVESDLVIRLVEGTADAATVVSRLGLVGGALRAIAVRPHGVDERQAALLLAFDRATTGFGWSRPGRSALVGSTLYTVLPGDDVASARAWVTALRTGLPFPVVAGIGGVASAADLPAGRQEADECLALHEAGLTVEPPAYDESWDDILLQRLRAAARVGRTPARGPVVELRAHDRQHGTHYAATLRAWLEAQGDPAVAGERLGVHQNTVRNRLRRMAEVTTLDLDDARKRLAMVIALAVADDPVANRQPGPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S7</accession>
    <name>A0A7W7T4S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamate synthase PgsB/CapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008337">
        <property type="entry name" value="Capsule_biosynth_CapB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01758">
        <property type="entry name" value="CAPSULEPROTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04012">
        <property type="entry name" value="poly_gGlu_PgsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="869" mass="94614" checksum="A44C5E94477FD6B1" modified="2021-06-02" version="1">MTYLYVVYLVMVGGLLMAGIAEQRRHLAHLHAIEHRVLVNGIRGKSSITRLCAGALRGGGLVTTAKTTGTAARFIHPDGTEEPVYRKFGVANVVEQIGIVRRAAAYRSDVLVIECMAVMPDLQEINQSKLIQSTIGVLCNVREDHLAEMGPTLDDVARSLSRSMPVGGVCVTAERDRLHILEKEAAKRDCELIAVDPESVSDEDMAGFTWVTFKENVAIALKVAELLGVNRQLALTGMWSAPPDPGVLSVQTRAVHGKTVRMANVFAANDPESTLMNIERLLEQGAIARPLHVVINCRPDRVERNRQMGELVARIEPDHVVLIGEPTRSARSTIAESWQDRVSDLGGSRGPEELVAEILAKVEDEVSLVAIGNIHGQGEVLLHALDEFEEIAADQAPRRTTVPDDHRPAPDRDHARLPAHDPRRPAAPDHGRSRAHDLRHPAAPDRTRPAGPDHGPIRADTSARDLPHPTAAPGPARNRPTGADASAPGRLPSGPGAETSARDLPRPPAPGHSRSHADTSARDLPRPVPPPHDRPGHGMAADEEHRSADPARPRPGRYDLDPPTELLPLVPRDAADAPAPRPYRPRRLVDDRAHDAAPARPQAPAEAPARRPDDRPRPGTYQPRRLADEPGSGRPAPDPHDPGTGRRRAPEPPGHEPREATGGPTRTGRLHRPDAESRPDEPPSRRSRPAAPPDRHPAPTHTDRPHPGQPRHTDRSHPGRPRQSDRTPQDDPRGAARPAVPPEHRPGHRHPDDPARQNSDGAPRPDRPGPPRRPEHGSTRRHGGHPGGPQGGHPGGPPPDRRTGPRPEQRPTGDRPRPDRQDQGPVDLHGAHRQNAPRREHAPGPTGEWPAPDRRDPPDRPHDRTRTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T536</accession>
    <name>A0A7W7T536_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="152"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="42867" checksum="3836A6F6DF67CA81" modified="2021-06-02" version="1">MERIDKRLVNWASILDEGARDQARKTATLPFVYPHVALMPDAHLGKGATVGSVIPTSGAIIPAAVGVDIGCGMIAVRTGFTAEDFRGRPLGALREAIEAAVPVSAGVYNTELTETAAERVAGLAADAERAGFDPADFGGNWRLQLGTLGSGNHFIEVTLDELDRVWLFLHSGSRGVGNRIAQKYIRIAREQCERRWIPLPDPDLAYLVEGEPEFWDYIKRMRWAQRFAWLNREEMMDRVVACVADWTGREVDRFETVNCHHNYTEQETHFGKKVWVSRKGAINAEKGRVGLVPGSMGTASYVVAGKGNPVSLNSSPHGAGRGYSRTAARKAFTQDDLRAAMVGIEYRDTDAFVDEIPAAYKDIDVVMRDAADLVEIRHTLRQIVNVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5A9</accession>
    <name>A0A7W7T5A9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly CpaF family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="229"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="49851" checksum="390BA312218B39C8" modified="2021-06-02" version="1">MPPLGWEPDEETADLSAATTRLRQHLRERLNAELPQRVADQQDRTGTTATREARRELARGILDEALRVHTENELAAGRQLLPREVEQRVMGEVVNELFGMAGLQPLLDDPTVETINANRYDRVFVQYNDGRRAPVAPIAGSNEELTDLVRLLAARASSQERRFDQGSPAVNLQLPGGERLFAVMGLTAGGVTALSIRRHGYLTVTLPELRRRGTLDPGLEAFLRALVKARKNVLITGGTGAGKTTLLRALAGEMDPLERIVTIEDAFELGLDHDPDIHADVTAFQAREANVEGEGAISQAELVRWGLRMSPDRVIVGEIRGPEVIPMCNAMSQGNDGSMATLHASSSRIAFTRLASYAAQGVERLPLEATNLLVASAVHFVVHLARAEDRRTRVVSSIREVVGADGPQVISNEVYRPGPDRRARPVAGALRSDTLDDLVDVGFDPGVLENPEGWWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y4</accession>
    <name>A0A7W7T5Y4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21844" checksum="4DB369CB99C1DD34" modified="2021-06-02" version="1">MSDDRLTAQERATLLVLLAEARELTNADLRAVAGLSLDGASRRRLNDLDLVTSTKVGRAYVHELTDRGAVRCAEEFGAERPARSGYASATLYAVLAGLRRWLDDTDHAVADLFRPDLARRVLDAHRAVTGAHGPVRLADLRDRLADVPRADLDRVLDALARRAGVHLWAEADQKTLTDRDRDAALVLGGSARHVLVVGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T614</accession>
    <name>A0A7W7T614_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="387" mass="42715" checksum="805832F71EBB9477" modified="2021-06-02" version="1">MDYPFERPQRLGVPEEFAGLRERCPVRPVSLRHGQEALLLTRYHDVRAVLRDHDRFSSDPARPGYPQLRPVVDRTAAPGSFLVTDPPLHTRYRRMLTGEFTVRRMAELRPEVERITAGRLDLLLAGPSPADLVAGFALPVPSDVICLVLGVPLDDQEFFATRSRAHLDRSLSAAEVGAALTELHDYLAELVRARRSTFRDDLVGRLLRDFPDLTDEEAVGMTVLLLVGGHETTANTISLSVLALHESGRWAELVADPSLVDSAVEELLRYLSPVHHGVVRAVTGEAALSGCPVKAGDGVVASLFAANHDPDVFPEPHRLDLARESRHHLAFGNGVHQCVGQLLARIELRAALRALVTTVPDLRIAVDRPEFRFDSPIYGLRALPVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T618</accession>
    <name>A0A7W7T618_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031328644" evidence="9">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11741" checksum="12EC2C21D690AEFA" modified="2021-06-02" version="1">MMFPLLLVLLAVPLFLSARKQKRAVAEQQSLLKSLEPGDRVMTTSGLYGTVYDASDDTTVDLEISEGIVTTWLRQAIREKVADEVEVPATADTRADDDTRKDEDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T628</accession>
    <name>A0A7W7T628_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone oxidoreductase subunit 5 (Subunit L)/multisubunit Na+/H+ antiporter MnhA subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="196"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="43056" checksum="3CAA942CDC00ABDB" modified="2021-06-02" version="1">MTASSPLVVAALLPAAVFLGLAAALWLGRRPSEDLVNRLVVGSAAATALAAALTGLGVLSGGPVTARLGTWFEGFPLVLLGDGVSVPLAVLAALLCTLVGAFSRRYLHRDPGYARFHLLLALFLAGVELVVLAGTLDLLVVGWELTGLSSALLIAFFHRRRGPVAHGLRAFVTYRVCDVGVLGAALVVHHDGPPLAAGLLLVFGSLGKAAQFPLGGWLPRAMEGPTPSSAIFYGAISVSLGPYLLLRTAPEWADVAAVPVVITVVGAVTAVYASLVGRAQTDIKSSLAFASMTQVGLVFVEIGLGWHVLALVHLLCHATMRSAQILRSPSLLHDHHHLEQSLGGPVPRTGRHLERLVPAPLRRRLYRFALERGHVDAVLVERVVGGLVRAVRRIGDADERLAVDPAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P2</accession>
    <name>A0A7W7T6P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="25338" checksum="11A5963B7BEA92B8" modified="2021-06-02" version="1">MRIAELSRQAGVPVATIKYYLREGLLHAGERTSPNQARYDDTHLHRLRLVRAMVQVGGLSIAKVREVLGALDDPERSEHRAMGAMSAALTPRHFEHDDKIAYEQARAFLKRNKWPVRTKLPAFQALVDVLAAARDVGHDRFIDHLDRYVDACMTMAEADVEYAFMAKTRDTSFENVVIGTVLGDAVVAAVRRLAQAEVSGRTLGEVKDEDEPEPDGPDCVENEWDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Q3</accession>
    <name>A0A7W7T6Q3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16654" checksum="A7555952EDD8150B" modified="2021-06-02" version="1">MTRRRRTRPRTPRPDPVRVEELVAYLRTDRRWRDEVAGRLVSRLDPRLVRSVRTCGCRPLAHVAEEFDSQACVDLGPSAPYQVAKAVYGQVPLRGAARLRYTARSLRVLGVFLCANDLAACPCTVALARDPRQTRIDRVVVGALDGAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T720</accession>
    <name>A0A7W7T720_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004586</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031246245" evidence="4">
        <location>
            <begin position="28"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="45447" checksum="5EA6997BCE522944" modified="2021-06-02" version="1">MSNLSRTVGVVVGVAAVAALATVPAHAAPAAPARFAMPALSGRYPVGTTDLHLVDRDRVDPWNAARQRELMVTVSYPAAGSDGPRADWMGTGVAQVADAVLSSEYFLDVPIGSVDWDGTTRQARTNVRVAAGEFPVVLFSHGWGGARELNAGVVDDLASHGYVVVSLSHTYESLAVGFPGGRVEYGVANEAELDHRKTAIDTRVADSRFVLDQLALIDRGRNPDAERDPLPRGLDDALDLSRTGMFGHSYGGYTAGEAMYADRRIDAGIDVDGAMAYSTPEPYFPGEAVRHGLDRPFLLFGGDFVENGQAVEHSHRTPEFDRTWADFWARQRAWKRDLHLDRATHYSFTDLQVAVPQLSGLLSPRRQAGIVGTIDPRRSLAAQHDYVAGFFDLHLKRRDRGLFHGPSPRHPDARFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T741</accession>
    <name>A0A7W7T741_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="81" mass="8603" checksum="72D1D9849ED38A92" modified="2021-06-02" version="1">MLSESERRTLIEIETRLTDEEPALATALVAGKPKHPVLVYSLAAVFVALGVLLLLLGSFGPALASLGSASAILLLRGFTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7F6</accession>
    <name>A0A7W7T7F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14647" checksum="B701E3C8C8E126DC" modified="2021-06-02" version="1">MSAQPTRILVFSHRPEVRETIITAVGRRPAPDLGRVDYVEVGAIADVLYEMDKGGVDLAILDGEAQPTGGMGLSRQLKNEIADCPPIVVAVRRKDDRWLATWSQADAVIVHPLDPLAAAETVAEVLRSTAVPVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P8</accession>
    <name>A0A7W7T7P8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="7586" checksum="517A352564839BEB" modified="2021-06-02" version="1">MSVLPAPLAITPRTSCGATPLVQIGTFTIAAAFVVVLVLLGQPLTGAAGVAAWLITTAVRSTTTKQVGPARDGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z0</accession>
    <name>A0A7W7T7Z0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="PTHR23427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29514" checksum="AEBB397FA7F03150" modified="2021-06-02" version="1">MRLKFLLRPGWLALTLAVWVFAAVCFTLLSPWQFGRDDERRTQNDAVTSSVRTDPVPIATVLDRPPAEVEWHRVTMTGRYLPEGQAVARLRTVQGEAAFEVLTPFALVDGPVVLVDRGYVRPVNGMRVPTLKAVPDGQVTLTAWVRAGETDDRDAFDQDGYRQVYAINPAVVGRAAGLDLRPGYFQLADAAPGVEESLPLPKLDAGPFYSYALQWIAFGTMAIGGWLYFTIREIKPGGALSEPRPRRKSVAELLAEDEAEAARTPAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T850</accession>
    <name>A0A7W7T850_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="8985" checksum="27A40F21476FE635" modified="2021-06-02" version="1">MSVKARTEVSVEVRVGIADSPRELQVSSGLTPDEVEAQVADALKSGSGQLTLVDQKGARFVIPAARIAYVEIGPSDARRVGFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T884</accession>
    <name>A0A7W7T884_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000896</name>
        <name evidence="4" type="ORF">F4559_001494</name>
        <name evidence="5" type="ORF">F4559_003062</name>
        <name evidence="6" type="ORF">F4559_003919</name>
        <name evidence="7" type="ORF">F4559_004875</name>
        <name evidence="8" type="ORF">F4559_005156</name>
        <name evidence="9" type="ORF">F4559_005945</name>
        <name evidence="10" type="ORF">F4559_006802</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15732" checksum="710B550B21352FC5" modified="2021-06-02" version="1">MLTPGQAGDSPQFRTVLDRIRVPGPVGRPRTRPDAVAADKAYSSKANRAYLRRRRITAVIPEKTDQRANRRNKGSAGGRPVSFDPVRYRRRNTVERLFQKIKTWRGLATRYDKTPQSYEAGLHLRGAIMWLKTLTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A0</accession>
    <name>A0A7W7T8A0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="2">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="8734" checksum="B24106DAA17B8566" modified="2021-06-02" version="1">MSGRPTGLAPGHGAGYTVTHTAGPEVVYTENLRSGTHLEAPEDLKTFSAVFEDLIAAAADPSDSRDLLDTPARQRERPEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B8</accession>
    <name>A0A7W7T8B8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="279"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="537" mass="55366" checksum="73D476C885718E49" modified="2021-06-02" version="1">MGKLINRWRVGRRIGVTLAVLLALTGTVAAVGLVGLRGQHQSAEEIARLSQLDNTAMQVKYRSADFNGWQTAYSFDVARGIAGAAEESASARTAFLKSAQAFQTELGALGALELTDGLRARVDQIGKDFDRFMKLDEQIVAAYRSGDPASVATANQLVAVDEIEIFNAIAAQVDQMVAEVDQAVADATANADTQSGQATLVMILLAVAALLIGGFCGIVLLRSITRPLTSLRAGLSDITEGDLTRRLDASGGDELGEVARSFNALATRMQELIGRVAQRAVDVASASAQLGGVSRQLAENADDTSGRASEASASAEEVSRMAGAMASAAEELRAAIDEITQNASRAAEVAGAAARDVVAADDTVTRLVASTSEIGEVVKLISSIAEQTNLLALNATIEAARAGESGKGFAVVAGEVKALAQQTASATEDITSRIRAIDTGSADAIAAIRQISAVVGSINDTQNVIAAAVEEQTAVTAELSRAVQETATGALRIAEGITGVAQGTETTSAAAGEARSTADDLTTASSDLNHLVSAFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8L9</accession>
    <name>A0A7W7T8L9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17379" checksum="96D3968DA8C24E0A" modified="2021-06-02" version="1">MSLVETSAALWRQRELLSMLLYKLQVESLVLASGRTRWLGTATHEVERVLARVREADVLRAVLVDTLVDELGLAPGASLAEIAEHVGEPWRDVFTEHRTALLAISAEISGAVRENRDRLTVGARAVRDALDAVGGDGSGPLYQANGSTVSAPVGARLVDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V2</accession>
    <name>A0A7W7T8V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="47"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="366"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="400"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="607" mass="65584" checksum="8C9451F0D1B356CB" modified="2021-06-02" version="1">MTVAEESWRGVAAEDVEDLEHAVDVKLRARSRRLLGSLLRPHLRVSLLALLIVVAENLANLAGPLLIAAAIDRGVPAAVSGDPGVLAWCVGGYVAVGLFATLMRWTFVRLSGRIGQDLLLDLRERVFRHAQRLSVSFHGRYTSGKVISRMTSDVDSLQDLLEEGLDGFFTSMLSLIGISIVLVVLDVRLALVVLAGFVPLILLIRWFRRRSATAYRGTRGAIAKVIVQFVETMNGIRAVQAFRRESRNERILAALNGRFRDANTEALSVMAAFTSSVRAIGNVSAVVILAWGGYLVAHGELELGVLAAFLLYVRRFYDPFDQVAMFANAYASATAALEKISGLLEERPDVPEPTDPTALPEVRGQVHFDRVGFRYSADTPVVLPTFDLHVPAGQTVAIVGATGAGKSTLAKLVARFYDPTEGAVRLDGVDLRSVADQDLRRAVVMVTQENFLFDGTIADNIALGRPAATRAEIEAAATAVGAHGFVSAMPDGYDTDVNKRGGRLSAGQRQLVAFARALLADPAVLVLDEATSSMDVPTERLVQRALERVLSDRTAIIIAHRLSTVLVADRVLVVDDGRVVEDGTPEELIGDAGRFAALHAAWRDSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V3</accession>
    <name>A0A7W7T8V3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridoxine/pyridoxamine 5'-phosphate oxidase</fullName>
            <ecNumber evidence="5">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PNP/PMP oxidase</fullName>
            <shortName evidence="5">PNPOx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pyridoxal 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pdxH</name>
        <name evidence="10" type="ORF">F4559_006067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + O2 + pyridoxamine 5'-phosphate = H2O2 + NH4(+) + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O2 + pyridoxine 5'-phosphate = H2O2 + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine-phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PTHR10851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4 5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="8">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_phzG_C" evidence="9">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5 6">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="24661" checksum="3B2AC72735BBAA4D" modified="2021-06-02" version="1">MTETTNVTLPAMRVSYEQGSLTESDLAATWHEQLQLWLDQAARAGLPEANAMVLATTDTKGRPSSRTVLAKGLDERGLVFFTNYTSAKSHDLMATRYASVTFPWFAMQRQAHVRGTVEKVGPAETAAYWASRPRGSQLGSWASPQSRVVTGRSNLESALHKIERQFADAENVPVPPHWGGWRIRPEEVEFWQGRRDRMHDRLRFRLGRDGWEVQRVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T932</accession>
    <name>A0A7W7T932_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16492" checksum="DB11FDC9A15C9BF3" modified="2021-06-02" version="1">MAEDVAALVRELDDRMLRDYRRMTMWRQVHRTTGVLYTVVLILVPAVLAVGFTTSETMLGKALLLIAAVVGGLNVTFKPYLHSQKRRADVNTMRRLRDEYRGELARAGASGAVDVYDKYSRTYATVFEARGQDLVDGTVERDPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T935</accession>
    <name>A0A7W7T935_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CarD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_065915127.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17971" checksum="828F59322FC6EA27" modified="2021-06-02" version="1">MVFKVGETVVYPHHGAALIEAIETRVIKGEEKKYLVLKVAQGDLTVRVPADNAEIVGVRDVVGQEGLDRVFEVLRAPHTEEPTNWSRRYKANLEKLASGDVNKVAEVVRDLWRREKDRGLSAGEKRMLAKARQILVSELALAEGTDEDKAEVLLDEVLATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T944</accession>
    <name>A0A7W7T944_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30776" checksum="BE46A95D3DCAB229" modified="2021-06-02" version="1">MVREQNPTSYKLQLGAALERFRLHAGLPRKAAADELGCSEGKIGTIERGDVAIRAAELKVVLDLYGVTGDERADVEHLAAEAKRRRPRTPWGSVIPDRLKKFFTTEETAVKIEAYLPELLHGLVQTEAYARAVLSTNSAFRPEEVERLVDARMARQTLLESSDAPALTLAVPEAVVRGQVGGPVVMAEQLAHLRRLARRPEITIRVIPTSLGAHAGSGLPFTILTPPQGRRRMVYVETLTDGLFVDEPLRVAKYETAFRELMGVALSPTASVALLATVAGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T957</accession>
    <name>A0A7W7T957_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="6">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysS</name>
        <name evidence="9" type="ORF">F4559_006230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 7">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="187"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="503" mass="56114" checksum="21125A8BF91E2765" modified="2021-06-02" version="1">MSEQIPAGTATSDDDLPEQLRVRREKRARLLDRGVDPYPVEVPRTHTLREVREAHPDLEPDTATGTVVGVTGRVMFVRNTGKLCFATLREGDGTELQAMLSLNGVGEQALADWKSDVDLGDHVFVHGEVITSRRGELSVMADSWQLAAKALRPLPVVHKELAEETRIRQRYVDLIVREQARNTVRNRAAVVRSLRDSFHRRGFVEVETPMLQTLQGGASARPFTTRSNALDIELFLRIAPELYLKRCVVGGIEKVFEINRNFRNEGMDSSHSPEFSMLEYYEAYATYDTNAVLTRELVQEAAFAIAGSHVVTLADGTEYDLGGEWTTLRMYDSLSDAVGEPVTPETPADHLRVLADKAGLETDPKLGHGKLVEVLWEHLVGDHLHAPTFVRDFPVETSPLTRQHRTEPGVAEKWDLYVRGFELATGYSELVDPVVERERLEAQARLSAQGDVEAMPVDEDFLRSLEYGMPPTGGVGMGIDRLLMAITGLGIRETILFPLVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D3</accession>
    <name>A0A7W7T9D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein (TIGR03083 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26666" checksum="41673CAA0EEDED29" modified="2021-06-02" version="1">MSGEIGYARLLDVLAAEAGALAAAVDGQRPERQVPACPGLTLGETARHVGSTYRLVTAWLRDGYQPLAWQQDPEPGQSLADYVRAGAGPLVDRLAAHRPDDPCPTWWPARGDHLFWARRLAHETTVHRMDVQGAAGRPLDPVADDVALDGVDEVLTLWLGHRLDVLTVRGTTEVVVSITAGGRTWLTRTGPGPASSWPADGTPAAGAVTGSPTAVYRWLWGRASGREVKISGDHDAIAQLWALLRLATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I0</accession>
    <name>A0A7W7T9I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12790" checksum="14EF3C10DB2E9BFC" modified="2021-06-02" version="1">MSETITWSPLCGETEFAELLNGLAVDFAPRLFAVVHEYRDRADGWIAAWGMAFPQHADVISVDGGLRLRLAEPDGAVRVFTSEAADVTARLVWLPAFNPRLEEPVESYDEDPLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9X8</accession>
    <name>A0A7W7T9X8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_006621</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="374"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="452"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="521"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="586"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4969262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="665" mass="71117" checksum="8ABD5A9D786DF25A" modified="2021-06-02" version="1">MSTPRLLSNRYELGETLGYGGMSEVHKGRDVRLGRDVAIKVLRADLARDTQFQERFRREAQNSAALNHPAIVAVYDTGETQTDYGPLPYIVMEFVDGRTLRDLVKTQGPLAGKRAMEIMADVSAALDFSHRHGIVHRDVKPANVMITRSGAVKVMDFGIARAVHDGQAAVTQTAAVIGTAQYLSPEQARGEAVDGRSDVYASGCVLFELLTGEPPFTGDSPVAVAYQHVREDPKPPSALNPKVTPALDAIVLKAMAKGPANRYQSAAELRADLVRVLSGQRPSAPAVMTAEDRTAVMNQTSSPRTEVQSGGRHRPSAVREEPSGYDPLDDEDLERRARRRKALIVGLVVLLCIAVLAMAAWITTSLLDNDDQTKSNKVKVPSLAGQTQTAARAAVAGAGLVFKIDLVPCQPGANGAPAPCGADGIDKVIDSDPPANSEVDRNTDVRVRIGSSPEQIDVPDLRGLAPQEAQAKLGSDFTLAPNQETVEVDDDTKVGKVAEQTPMPGTKAAKGSAITIRIGKAQDKVQLPDVTETDAADAKATLEGLGFKVQTKEVDGTAKQGLVVSQDPPSSRQPKGTVVTLNVSRGNQILMPDIRNMSETQARTKLQQLGWTGDLQENGKTAVSDPSKDNKIQTQSVDPQQPITKNQRITVSVGEFRPGGPTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAA3</accession>
    <name>A0A7W7TAA3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009597">
        <property type="entry name" value="DUF1206"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06724">
        <property type="entry name" value="DUF1206"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="102"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1206" evidence="2">
        <location>
            <begin position="197"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="27802" checksum="41D3FED2B1DF97E4" modified="2021-06-02" version="1">MATAGEVRRHPTIQVLGRAGMVCYGVVHVLLAVLTAQVVFGDAGEQTDQKGAVALVAQTPFGPVLLWVLAIGLFAFAVWQAGLAVSGYTWVPDEKKRWLRRIGAGTRAVTGVAIGIAAITYAVGSSSSSSDEQQQTLTGRLLELPAGPFLVGAVGLAVIGIGFAVARKGVKKKFEDDLDMGELPIGARRWVERSGQVGWVGKGIAYGVIGVLVGLAAVTHDPSQSGGMDKALHTLAAQPYGVFVLAVVALGFLGFAVFSFAAAKAHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAU0</accession>
    <name>A0A7W7TAU0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+(H+)/acetate symporter ActP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="595" mass="63073" checksum="95F329D85FE228CC" modified="2021-06-02" version="1">MTQNLWSVGLVVVVATITFLLGYVGSRRANTTPDFLVARRAIPATRNAAAISGEYLSAASFMGVAGLILKDGIDALWYPIGFTAGYLALMMFVAAPLRRSGAYTLSDFAEARLGSAALRRWCTFFVICIGVLYLVPQLQSAGLTLTTITGLPAWLGGAIVTVIIVANVLGGGMRAITLVQAFQYWGKLFALAAPTFVLFTVFLSGPGNGAQAVDEPGVLLFHEDVSVTAPDPVKVRVVTPLKLSATGEVNGARADGDVYWTDGVYSIGKGTVLRFTKGSPVPVVEGSPGDNDRWLRPQTNGVPGLFETYSLIFATFLGTMGLPHVLVRFYTNPDGKAARRTALHVLYLIGLFYLFPTVLGVIARQYLPQLLVTGKTDAAVLLLPGTMMPNLAGQILGAVVAAGAFAAFLSTSSGLVVSVAGVVSTDILPGKVRDFRWATVLTGASAIGLAFVLPPSDASLTVAMSFALAASTFCPLLLLGIWWRGLTWVGAIAGMVVGGGLVIGAQVVNVISSYTGGWAHSVFAQPALVTVPMAFAAMVGISRLTARRRPEDVNQILLRFHAPDPLGFMRDRDVQRFGTPREKARLDGRHRDLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCZ9</accession>
    <name>A0A7W7TCZ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="5825" checksum="AB58B276AC8310A1" modified="2021-06-02" version="1">MVRIIVWLLAAWVVISVLGAVVKGLFWLAVVGVVLFVGTAAYGAIKSKGRKEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WSY2</accession>
    <name>A0A7W7WSY2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031301423" evidence="1">
        <location>
            <begin position="25"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16343" checksum="8B6E827B41348F74" modified="2021-06-02" version="1">MADKRGALAALCALLLTGCGPAVAGTPKPLTITDTERALVSGYFDNLNKAGTAGVDKQRELLRETQHPDFEDDDCELPEGTLRVVPTLATLRLDADWTPPEQDEHPRGVVFVVAVTLTLFQEGTEIGSQIGSQHVVLLNGRAYGFAPCITRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTD2</accession>
    <name>A0A7W7WTD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="12912" checksum="C66FE10298B0075C" modified="2021-06-02" version="1">MDDTTRAAEQAAHTGQRIAEHLDRTGPVLGRASSPDGAVTVTTPPGTPPTDIRVTAAALNMGPQALAAEIVRVAAKASRDAAARLHRSLDRVVDPATSRALTEMGFAPGEVEDDFTGGYLRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTG7</accession>
    <name>A0A7W7WTG7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphomannomutase</fullName>
            <ecNumber evidence="8">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="7">
        <location>
            <begin position="172"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="537" mass="56167" checksum="135EC2E00D8F0266" modified="2021-06-02" version="1">MSLSPALRDAAFRWIADDPSPEDRTALQNLVASAMVGDAAALEELADRMSGPLTFGTAGLRGPVRAGPNGMNRAVVVRTTAGLAAWLRSRGTVFVGRDARHGSEEFCAAAASVLAAAGFDVRVLPGPLPTPVLAYLVRRNDALAGVQITASHNPPADNGYKLYLDGGGQIVPPADREIEAAIAAVPSAVSVPTSDSYTTLPDSVVEEYLDRVASLPTGTSRDLRVVLTPMHGVGGATAVAALQRAGFTDVRVVREQAVPDAEFPTVAFPNPEEPGAADLLLELAASSGADLAIALDPDADRCALGVRERDGSWRMLRGDETGVLLGSLVLSTTTQPDPLVATTIVSSSLLKSVADKAGARYAETLTGFKWLVRAGEGLVFAYEEALGLCVDPAAVNDKDGISAAVLACDLAAGLKSSGRTLLDALDQLAVEHGVHLTDQVSLRFDDLSRIGALMSRLRANPPEGFSFEDLLPEADVVRLRADGVRVIVRPSGTEPKLKAYLEVVEPVADDLAPARSRAQARLAELRAVVSGLLTTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN7</accession>
    <name>A0A7W7WTN7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family leucine-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16287" checksum="93D5EB4FE12DE0D8" modified="2021-06-02" version="1">MTLDATDWAILLELQADGRLPFTELGRRVNLGASATADRVKRLEETGVITGYRAEVDLDKAGYPVLAVVRLKYPGNRHQPLHALLAERAEILECLRTTGDDCYSLKVAATSMAHLERVVNELTDFGSTTTNIVYTRTLPYRGVSTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTY5</accession>
    <name>A0A7W7WTY5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ORF">F4559_000556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="172"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25827" checksum="2E94BD1FA667F03F" modified="2021-06-02" version="1">MDIVVKGRNVEVPDHYRVHVAEKLARLERYDRKVIRFDVELFHEPNRRQAKNCQRVEITGKGRGPVIRAEACAGDFYAALDAAVAKIENRLRRAHDRRRVHHSRRGLTSVAEATSGLGGMPSSPADRDGEVQRAWQGHTAVLEAAEPEAAYGSLAEVPAQQRWEDVEDNLPGQVVREKEHTAKPMTVDQALYEMELVGHDFYLFADADCGRPSVVYRRKGFDYGVIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU22</accession>
    <name>A0A7W7WU22_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7076" checksum="6C412417B00BC48F" modified="2021-06-02" version="1">MAAYRSVRLMCDGARCLTEYIPTDPTPTASAARYLASRRGWTTVARRDYCPACCPATANTTAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU54</accession>
    <name>A0A7W7WU54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="58" mass="6572" checksum="CB8F6D6CD9F4A44A" modified="2021-06-02" version="1">MRCIMQNPGVNEHEPAVAVIVTHVEDGNRIPICKRDLDWWLDDADDNPGMEPADLVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK3</accession>
    <name>A0A7W7WUK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="20839" checksum="3D6E6A310B2AD0D2" modified="2021-06-02" version="1">MSEHRHASARPSATGPWVIDTRDLGRRAGSSRAYRRSVPAEGVGLLGVIAVPPGGEVDLDVLLESVVEGVLVTGRASTAVEGECSRCLEPLTDEVAVELTELYAYPDSATDETTEEDEVSRLADDLVDLEPVVRDAIVLALPQVPLCSPDCPGLCVDCGGRLAELGPDHGHETMDPRWAALQERFGGNRDNPEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ6</accession>
    <name>A0A7W7WUQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose biosynthesis protein BcsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30383" checksum="BF5DCCCB04A41639" modified="2021-06-02" version="1">MHTVAVLSLKGGVGKTTVALGLASAALRRGVRTLVVDLDPQCNATSTLEPEDTPASVYDVLREPTAANLRDAIAPSGWGESVDVLAGSEDAESLNHPDPGESRLNRLRDALRLLQDQEEPYQLVLLDCPPSLGQLTRSALVAADRALLVTEPTMFAVAGVQRAFEAVQAEREHNPDLQPLGVVVNRVRPRSHEHQFRIDELRDIFGPLVMPVALPDRLAVQQAQGACMPIHEWGTPGAREVALAFNLVLARILRMSRSRRRAVHRDFDDEEIQEAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT9</accession>
    <name>A0A7W7WUT9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031350679" description="Glutathione hydrolase proenzyme" evidence="6">
        <location>
            <begin position="28"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="590" mass="61851" checksum="81037E04B567D3CD" modified="2021-06-02" version="1">MPRSRVVGVLVSAVLVGSVLPASVARAAEVPRVPEAVGRGGAVASIDPDASQIGVDVLRRGGNAVDAAVAVAAALGVTDPFSAGIGGGGFFVYYDARTHRVSTLDGRETAPASADEALFLENGKAIPFADAVTSGLSVGVPGTPRTWQRALSTWGTWSFDQVLRPAEDLARRGFVVDPTFRRQVDNNAARFADFTSTRDLYLPAPAVGSTFRNPDLADTYRELRRGGVSALYRGTLGRELVDTVRTPPVVPGTARVVRPGDLTTADLAAYDVVRREPTRTRWQGYDVYGVPAPSSGGTTVGEALNILEAGVPDGDEASGPFLHRYLEASRLAYADRNRWVGDPAFVDVPTKELVSQRFADSRACLISPTRALPGAVAPGDPRAPRPCADSGVAAQTPYEGRDTTHLTVADKWGNVVAYTLTLEQEGGSGIVVPGRGYLLNNELTDFSFTPATPGVPDPNLPAAGKRPRSSISPTIVLRDGSPVLALGSPGGASIITSVLQVLLNRLDRGLSLVDSVGAPRASQRNGATTQAEESFLATPEAKWLEGLGHRFTSTAEIGAVTAVEPAGGGRWRAVAEPTRRSGGAARVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV01</accession>
    <name>A0A7W7WV01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfoxide reductase heme-binding subunit YedZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="276" mass="29750" checksum="8F6EFE4820E3A787" modified="2021-06-02" version="1">MLSQVPSLVAQATGDDHDAGVRHVAQLSARTAYVFTCATLSWGVLIATGWANRIAGRHGLRNSHMVLATLALAFGCLHAVAFTLLRVDPFGLARIAVPLADGGQARHAPGIVGLELMLAIACTAGLRKRIHYRRWLRLHQLAYPAVALTVVHSWLGAAANGTVAVLWLAGLTVLVPTVTVAAARFLPPHVLVRLGMLEPEPGFAPGPGGTGLDVSVDNERCHRYGVCQAEAPVLFQLVDDERLRYERRPPPELFAKARAAARACPMRAIELRERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV40</accession>
    <name>A0A7W7WV40_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="110"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="31872" checksum="1AC467E9817059CB" modified="2021-06-02" version="1">MLDDDDPGPIVQRLIFGAEMAELRGKAGFSVDEANVTIGERLAVNPAAKRGWYRGKLGKIENGDLNISDVELDVAFALYGVGGSKASEIRTLAVEARRRQTPIRVPDHGRKYIWLERAADEIRQFFAITVPGNLQTAEYALMQMSTSLVMAPVDLPEMAAGRVARGDRFAADEKRVLHTVIGEAALRTPIMNPGVMRGQLDRLLALAERPNITIQVVPMEVGLQASLEHSYSLLHIARARTTIVYVESLTTADYLPRPPHTTTYGLAFEKAQSLALGPAASVDLIRSISGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF3</accession>
    <name>A0A7W7WVF3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="28723" checksum="4E2C8EAAA22DE189" modified="2021-06-02" version="1">MLYHLAVAGGRHRGIEIHCSASWLVKTKSETVIRDDFVRAVVPMVDNSGVEMKILLGLLSRMVAILAAMAFMLSIPVAAANAAGGDFVAQDASAVLDRLSATGRLTAGDRDILLKYPRLAAQVEDPDQATSGGSVRFDAERAKLVGAQGCWISDWYHHAKTALGNTFYKFHHRADWCQDGNRVLGVHYRSHHFSEVSAFAYPRHVESDYVTPTPSWEVKSRKSHLVDNCIPLKGCLWASHPWVEHTMRGNAENWSADGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF5</accession>
    <name>A0A7W7WVF5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030937562" evidence="1">
        <location>
            <begin position="24"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="370" mass="39158" checksum="B32E0181A6F68101" modified="2021-06-02" version="1">MFGGRKVALAVLIALSVSPTAQAEQPGVVDMVALSETNALLQASVPDSGALGVFFDERIGRFTVVLPPGVSTFVAADGTRPVVRRTATTRAALDTVDRRITELVTRDKALGYEVGSAYDLLRDTLVIQSNAPVEALTALTAGLPVKAEVRRSTERLRKSRQYDPAPHRGGAAISTAAGNCTSAFTVVSPDGDRYLVTAGHCGQFPGRPIGEPVWNTGSGEHLGYFYNWFYPDRDVALIANFDPGVFGHHIYVGGAEGTQKPVRAATDPVPGSSKYCHSGKNSFEQCGQRVVSLEGTLTSPEGTTRSLIAYDKGVSLRSGDSGAPFYWHTDDGHAVVVSGMSIGGKSDGTSYAEKWSLIAQSQGVQILKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK2</accession>
    <name>A0A7W7WVK2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PqqD family protein of HPr-rel-A system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027599">
        <property type="entry name" value="PqqD-rel_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04353">
        <property type="entry name" value="PqqD_rel_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9355" checksum="184BE1C0ADD4D346" modified="2021-06-02" version="1">MTLRPRAQVTMTRADDGMVVLDERTGRYWQLNHSAAYMLERLVDGDTVDQVAEHVAASAGVDTADVRSDVDAFIGRLRHAGLIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS8</accession>
    <name>A0A7W7WVS8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DsbA family dithiol-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22688" checksum="ED01D97E87144F10" modified="2021-06-02" version="1">MRVDVWSDLVCPWCYIGTTRFERALADFPERADVVVAHRSFELDPGRDPGRVETVESMLVGKFGARGADMDGQVAELARAEGLTYRTDREVGSTLDAHRLLHHAGEGRGRLQHAMFEAHFGHAESLFTAASLAAIADRAGFDPDATRAVLADPGAHLEAVREDERDAARLGATGVPFFVVDGRFGVSGAQPVEAFERVLRQAWDSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU8</accession>
    <name>A0A7W7WVU8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="1">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29507" checksum="0E867AFA21100A34" modified="2021-06-02" version="1">MTTSRWTAALAAVRRGWPVLPLRPYRKVPAVRDWDRTATLDPARVREWWAYSPFNVGISCRGAGLLVVDLDPPDGRTTFTRLGEIEPTYTVRTPSGGEHRYFLAPPGVELRNTAGRLGPGVDTRAAGGFVTAAGSVLRTATGFRAYETVLDLPVAPAPEWLVSALSPTPAPTRIVVPVQRPSPRRIAAYRAAVVEGEVDRVRTARPGTRAHVLFTAACRLGELVGAGWLDESTATALLLAACADHEGVDGWTPREAAHHVGNGIATGRRSPRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX3</accession>
    <name>A0A7W7WVX3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="31807" checksum="13C49928810E3F82" modified="2021-06-02" version="1">MAKPKRFPRALYEAELVRLQGRLVELQEWVKATGARLVVVFEGRDAAGKGGTIKRVAEHLNPRVCRIAALPAPTERERTQWYFQRYVDHLPAAGEIVLFDRSWYNRAGVERVMGFCTADEYRRFLRQCPVFERLLVEDGVLLRKYWFSVSDVEQERRFRERLDNPLKRWKLSPMDLESITRWDDYSRAKDDMLVHTDMDFAPWTVVEAEDKRRGRLNMIAHLLGSVDWTPVQRPPLVLPARPAGGGHVRPPREADRLAPDHARTLLDGPPREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWE6</accession>
    <name>A0A7W7WWE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA (YjgF/YER057c/UK114 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="12802" checksum="88F4911BFD2FF3CC" modified="2021-06-02" version="1">MNELLRPEGLVHSPAFTHVAVVPPGATTVHIGGQNAVDGSGALVGTDAARQTRQVMANLRDALASADATVHDLVMLTILLTTDADLGAAYPVAAAALDGAAPPVVVTRVAGLAVPGALVEVAAVAAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWI0</accession>
    <name>A0A7W7WWI0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding SARP family transcriptional activator/TolA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="5">
        <location>
            <begin position="101"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="717"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="797"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="837"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="930" mass="103179" checksum="B1976D783A07060E" modified="2021-06-02" version="1">MTGELRVLGQVEVLVDGTHVDLGHARQRCVLAVLAVEANRVVPTDQVVDRVWGDHPPRRARQLVSNYLSLLRRLLAGAGVDGVAIERRGGGYVLLVDPRRVDLHRFRRLVADARAQTDQARALELFEQATAAWRGEALAGLDTPWIATVREGLVRERFAADTDRLDLALRLGRHTALLPELTGRADAHPLDERVAAQLMLALYRAGRPTEALDHYRRLHARLTAELGTDPGPDLRKLHQDILTAAPTLTGTPPGRASVTPRQLPSAPALFTGRRPELAELDHTLATTRDDPETTGTVLISAIGGVGGVGKTWLALTWAHRNLDRFPDGQLFVDLQGFSPTNRPTEPADAIRGFLTALGTDPARLPADLDTLAADYRSMIAGRRVLVVLDNAATAEQVIPLLPGHPSCTVLVTGRTGLASLIDRHGARHLSLDVLTRDEARALLARRLGDRRIQAEPDVTDDLIDLCGRHPLALAITARHAATRPRVPLAEFATELRDLGLDALDDDDPAASLPTVLSWSLRHLTDRQRTLFVLIGIAPGPDIDLPAAAALIGLSKADTRKILHALENHSLLDRHPRGRYAMHDLVRAYATADDHLTEPARQAALDRVVDFYLHTAYAADRHLNPHRQQVTFDPPATGVHPHPLPDLTAVLDWLDVHHPHLLAAQSTAETRRRHQTVWNLAWTLGSFHWRRGHRRDALTVWQAARTAAEHLPDPNTRILAHRRLGNAHAEMEQHEQAMIHLYKALTLAEHHQDPAQQANAQETLAWAWARQGDDRKALEHEQRALAIYRTLGNPVWEAEALNSIGWYAARIGDYDTARDHCEAALSLNREHDNPDGEATTLDSLGYIDYETGNHREAIDHYHQALTLYRELGDTTNTAETLDRLGHPHAALGHHTEAREAWQEALDHYRRLGRDTDAEQVRKQLDDLTEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX26</accession>
    <name>A0A7W7WX26_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-degrading monooxygenase HmoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="12006" checksum="527A75E361FB6B57" modified="2021-06-02" version="1">MFVATNRLFVPEDRAEEFEERFRDNMRTYLPGVKGLRRSTLLRPTTPDQPYVSINEFDSEADFRAWVASDSFREAHKRNANVARHVTGNAVETFSPAEDLVLTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX60</accession>
    <name>A0A7W7WX60_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="841" mass="86569" checksum="5BEE76B86EF33515" modified="2021-06-02" version="1">MSVRSIAWQMVKAHRLGFVGAFIAILCGTAVVAACGVLMESGIRSGVPTERYAAASVVVGGAQVVQPDGAPFMEAKPVGSVPTIPVELAAKIAAVPGVASTAVESTFEARAVAADGTVWQALGHNWESAVLTPFDVREGRAPDGPDEVVVDAGLARRAGVEVGARLGVMTTSTPTTYRVVGIAGQDGLAKQSGLYFTTTQAEHLSGEPGRVRAIGVFARDGVDPSDLAERIERALADDHVTVAAGEDRGGVEFAEVGQSRVMLMAIAGSFAGIALLVAVFVVAGTLALSIDQRRRELALLRAIAATPRQIGRLIGLETRVVASAAAALGAAAGVLVADRLRDGFAAIGVIPHDLALAVGPIPLVAAFLLGLGAAQLAARVAARRPARIPPTEALVEAAVEPREPGRWRGVTGAGFLVFGAALAVVPLFARTEAALAMTGMSVLLMVVGVGVLGPRVAQPLVGLVARPLAAFGIGGYLAAHNSRANARRLSAALTPLMLSIAFAVVNFYSQTTIGTATRQEADAVTTADQVLSAPGGLSPEVADAARRIPGVGAVTPLVRTNVITVSGTGEAVHVTRSPASGVDSVSGNLDFGVVTGSLDDLRGDTVAVDGESGDDVGDEVELYLDDGTRTTLRVVATYERGLAFGRYLLPADLARAHSSTRTDTSVLVRLSPDADHTATTPALAALSDRYPGLTVTDRSQLAPAERAEQRTQFWVNVLAMGVILGYIAIAVANTLVLTTAQRRREFALLRLIGATRRQVVRTMRAEALLLVGIAVAAGTLLPAVPLVLLSIGLTGSPLVAGPLPVYLGVVGFTALLGFLAIGLPTRLSLRARPIDAIGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX73</accession>
    <name>A0A7W7WX73_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18857" checksum="05110117BE6ACFD5" modified="2021-06-02" version="1">MIDQLTVDAAVADARLAAMEFDDARVWLRAHQTLMEPLAAEVWVTDPTYSHVLLVQHRVRGWVPPGGKVEPGETPREAAARELVEEAGVAGKLLPVPAAVAVRSFRADWAPTLSLSYGAVIDRDVPLGGETGQPSRWVDLDETWESVFPEDRERIRAYVHRLATENVVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM2</accession>
    <name>A0A7W7WXM2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="35500" checksum="B140ACB423BA8040" modified="2021-06-02" version="1">MTEGIGPSVLRRIVAAWPRRAAVARDPQAADRTDPYDPEVPDYPLSVVPFAEHPRFQDASPERRSRVLTGLWLGYNERVVETERLVAEPGFRLLVDGAFPGTSPLLCQAIRQSIVDESYHTYMHWTAHTRTMELRGVRERPPRPTLVTYRRLRAAMDAMPEAWERDIAVLVWSAVAETCVNSLLALVARARDIQPMHSLITTLHLRDEAAHGSILVEVMRELFVHMGREQRAAVARCLPLALDAFAEQDPGVLLAELRAADVAGAEEIVGDLGPGRVVRDFTGARRLVAELGLLDRVDFDFGEQPDWSPLRDPDLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR5</accession>
    <name>A0A7W7WXR5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name evidence="2" type="ORF">F4559_004999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22568" checksum="1E18799EE1B8E8DD" modified="2021-06-02" version="1">MPTVEEAVAEQERLRPLVRAVADPDFTPRFVAGLDVAYGDDDRVVGAVVVLDADLRTVDEAVVSGVAEFPYVSGLFAFRELPSLLAAVKKLTVAPDLLVCDGQGVAHPRRFGLACHLGVLADLPSIGVAKTPMGPYDLPGTAKGSCTDLVDDGEVVGRALRTCDDVKPVFVSVGHRIDLDRACAEVLRLCRTRLPETTRRADSLGRRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXT7</accession>
    <name>A0A7W7WXT7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23301" checksum="31EF3A5FA184202A" modified="2021-06-02" version="1">MKEHRRELVRLCRVAIDRPRPQLVVAVLVSTWSLGWVVGQVRSHPSPLDVLAAPLEWAAVPTGWLAAVDAWLTGRTAFLAVAGGLLWAMTTPRRQGGAVLGWIAVMLAAESVGYGAVHRALLTLAVFLFVLVVLSVPGRRAFVVDRIALIPGDVLRAAATALALAAVVPLLAPGLLVAALLGPYVTRPPRARVVEVNGRSRNGVVPAGETRPVPVPRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY1</accession>
    <name>A0A7W7WXY1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="73"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="31417" checksum="2A97163F425D53C4" modified="2021-06-02" version="1">MPLNDQARAVLDKLSGAAPVTTPAAARSAAGGYLAFQGAPADVSVEHLFVPGPTADLPARVYRPRLDGPLPGIVFLHGSGWTICNLDHYDVILRALAEATGHVVFAVNYQKAPEHPFPVPLDDCEAAATWFVRNAVRFGVEPDRIGVFGDSAGGNLAAALTLRRTVPFAFQVLVYPALDRDFGTQSAVDFAEGYGLDADTMRWFWDQYVGATTPVEATPGRGDLTGLPPAFVATAEYDPVRDDGERYAAGLAAAGVPVRLRRFPGTIHAFLLMDGVLDEARTLLAEVSAWLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY64</accession>
    <name>A0A7W7WY64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="165"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="36680" checksum="78EBD8CACEAE60AD" modified="2021-06-02" version="1">MGRWVRTVVGLLLGFGTALPGLVAAASPRAATRMVVLERRRLARFLGVESGEPGPGRAARYLLVHAAVGLLGGFVVVWLCYGLYYVPVVAYRLLSGEVDPLELVWTGFVGLVLLYIESQGIAGVARLDAAAARRLLGRGEAEVLRERVGELAASRAGIVAAVDAERRRIERDLHDGVQQRLVALGMLLGRARRHPERADELVAQAHEEAREVLDDLRAVAWRVFPAALDALGLAEALATVADRSAIPVELSCPPTATITPVETAVYFLVSEAVTNAVKHSGATMIKVDVTREDDVVRVLVEDDGIGGADPAGGGLSGLSRRVLALDGTFGVTSPEGGPTAVVAAIPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD2</accession>
    <name>A0A7W7WYD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011200">
        <property type="entry name" value="UCP012608"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10094">
        <property type="entry name" value="DUF2332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="37914" checksum="4435CDD4481EBE90" modified="2021-06-02" version="1">MLAELFLDASDACRESSPLTRALLVSAADDLAGGGVTARIMAGAECDRAASAPARRFASAVHRLVLEGRAPALAGHYATVGGRLDAGAFWADALPVLEEHADDLHTVIASAAVPTDEPGRSSPLFGGLQTATHLAADAAGRRTGFPVRLLEVGASGGLNLRPHRVAYRVDDDLLGDRHSPFTLDAGWCGRPDADVTRNLRLVRRAGCDANPVDVSTVDGRLSLSAAVPGDRADHYERLQAAFALALLDPVPVSRAAGPEWLAEQLARPERDVLTVVWHSLVWHHVSPADRAMGREVLAGAAARATPMAPLALLVYEPRRSGEHYELLLKLWPAGVSLRLGTGAPHGVPFTWDVRAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL4</accession>
    <name>A0A7W7WYL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetic acid degradation operon negative regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011965">
        <property type="entry name" value="PaaX_trns_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020623">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="160"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28374" checksum="9CA6BDD6DF8F43D1" modified="2021-06-02" version="1">MRARSALFDVYGGHLRERGGAATIAALVRLLEPLDFAAPAVRTAVSRTVRQGWLEPVRLAEGPGYAMTPRAERRLDEAAARIYRTRPSTWDGRWHVVVPDVPPVREARDRLTSSLQLLGYGALGPVAWIAPRPSPELADVLAAEEVAATSFHGEHEGDPRELAAKAWDLEALGQDYALFVAEWEPLVSAVDGTAPATAFAASQRFLHAWRKFLFRDPGLPRELLPAGWPGLAAAEFFDRHTARLAPAARRFVDDSLGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW6</accession>
    <name>A0A7W7WYW6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinogalactan oligomer/maltooligosaccharide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030711231" evidence="5">
        <location>
            <begin position="41"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="276" mass="29506" checksum="4BD7C121FD03B907" modified="2021-06-02" version="1">MKRSPLASVGLHAALVCASAVAVFPVFWVLVTSFKPDARAVSSRLLDESTVDNYVRVLSGEKGDFLAWTANSVSIALATTVLAVFLSATAAYAASRFRFAGRRVLLRSFLLVQMFPFAVLIVPLYNVLLALGLQGSSFGLVLVYCTTAVPFCTYMLKGYFDTVPAEIDEAGRVDGLSPFGVFWRLIVPLSRPGLAVTGFYAFLTAWGEVAFASALLSASDESKTLAVGLQVFVQQNRTEWGHLAAASVLVALPAVALFYPVQRYLVTGLSSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ77</accession>
    <name>A0A7W7WZ77_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14663" checksum="ADA28B29C9B79381" modified="2021-06-02" version="1">MNVLDRGRDQALALFRIVIGFLFANHGLQSLFGLFGKSAVSITSWPGGPAALIELVCGTLVCVGLATRPAAILASGAMAYAYFVVHQPEGLLPIQNHGEAAALYSWAFALLIFTGPGAWSLDGYIAAQRQKDASAAAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ83</accession>
    <name>A0A7W7WZ83_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIIJ-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="2">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19347" checksum="6742698002815475" modified="2021-06-02" version="1">MSETLQAADTADAEGDEAQARSGNPEDLLVQEGDIAGDYLERLLDLLDYDGDIDLDVEAGRAIVSIDGGEDLEKLVGQRGSVLESLQELTRLAVQQETGVRSRLMLDIAGWRAGRRAELAELGRSTAEKVVASGEKVRLHPMTPFERKVVHDAVAAVAGVFSESEGEEPQRRVVVLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZK3</accession>
    <name>A0A7W7WZK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="397"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="603" mass="64952" checksum="FCFB7493C7083FF1" modified="2021-06-02" version="1">MTTHPTADVPAQLFADPAAEERWRSRFTAPRVTLPDWADDAPDRSLYLSNSSGVWEIYAWDRASDSHRKVTDRPNGTSHATLSPDGETIWWFSDTDGDEFGIWVTEPFAESGGSAEPGVDGVHAGYSAGLAVGHDLVAVATSTDDGTVVHVSRSGGPAEVVYEHRNDAGLAALSKDETLLAVAHSEHGDNRHLALRVITPTGDKVAEKWDGPDKGLDAIAFSPVRGDNRLLVGHERRGREELLIWDVAADTETELHIDLPGEISADWYPEADALLIVHTFRVRNTLHRYDLKTGTLTTLGTPRGTVGSASVRPDGAVEYSWSSAARPGVVRVLDTDGDERVLLAPAGHTPPPSVGLEDVFVGDVHALVARPENAPAGPLPTVFLLHGGPHAADEDRFSAYRAVWLDAGYAVVHVNYRGSTGYGSAWRDATTGRPGTTELEDVAAVHDWAVAEGFADPAKCVVDGASWGGYLTLLALGTQPERWAAGVAGVPVADYVAAYEDEMEPLRAFDRALFGGSPEEVPDLYREASPLTYVDDVRVPVLVLAGENDPRCPIRQIDNYLDRLAARGARYEVYRYDAGHGSLVVAETIRQTAAEVAFVGRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X017</accession>
    <name>A0A7W7X017_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5367" checksum="2849D9B00F52DB28" modified="2021-06-02" version="1">MNIAAKLRARRVDARNRKAVARALEQAPTPAMRHELMAIAQAQVTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXJ0</accession>
    <name>A0A7W7SXJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13385" checksum="0B4E6BD2DCF3A585" modified="2021-06-02" version="1">MTDLLAALAALLDQVDPMPRDLALRATQALRARHDEHAATLWHDSTRHGARTLRFAGLDLHLDPTRGGFALTGLVTTGTHAVLHHPGRTRTVPVVDGWFHVDPVPRGPVKAVVDDVATPWFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY90</accession>
    <name>A0A7W7SY90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17284" checksum="3367B9BDFD147E9C" modified="2021-06-02" version="1">MSTWTTPSPVELALTRSFDAPQELVFAAFTDPARVVNWLLGPEGWTMPVCEIDLRQGGRWHMEWRRADGSELSTDGEYLEVTPCSRTQQTESWGGDWARTVNTTEFVADGASRTTVVRTMWFPSREARDRALGAGMDDGATASYDRLEAYLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYY8</accession>
    <name>A0A7W7SYY8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHS repeat-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="369"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1492" mass="161357" checksum="1BEADEC9542B3067" modified="2021-06-02" version="1">MNNPLVATAKSDTTAVTGIGIAESANDLAQGISDGSWVAAGLGGVGVGLEVLSMVLDPVGTVASYGVGWLIEHVQPLKEALDWFAGDPPVIRSFSETWSNVAAEVARVAEDLAAQDAPGWRGEAADAYRGHAAQTADAIAGAATLAEGVGVGVMVMGEVVAAVREIIRDLVAEVVGKLITWALEAVATLGLATPLIVAQATSTIARVCNRIADLVRKLVKTIGNVTPRIRKVLDKLGEIMEKLGKLGRRADGPSSPGTTSTSSAPDAPTVKGPDGTTTPSSTADTTSPSGTTSPSGTTSTSGTTSPSSTTSPDTASSGITPAGTDGNGSSPSGSSRPRSSSSDRPSLREDTPNPRDRAQPPEGRCEGREPIDLASGEMYLAQIDVDLPGVLSLLVGRVHVSSYRAGRLLGPSWASTLDQRLEVDDHGVYFADPDGVVLVYPLPPSSGAPVLPVEGARWSLARTDSGYVITQPRTGRSLHFPDAAHAPISAITDRNGNRIDFEYTGAVPSRIRHSGGYDIVVDTENGHVTGLRLVSPAGGEITLVSYRYDDNRLTEVLNSSGAALRFEYDHAGRIIRWIDRNGEWYGYEYDHNGRCVRTTGSGGALTGEVEYNPAAGVTREIDSLGHVTHHHFNDVGQLVRRVDPLGNQTLFHWDRYDRLVSTTDALGLTTSYLRDDDGEILVLTRPDGTQLLAEYNEFGQPTRQVDPDGAVWFKEYDSRGNLVAVTDPSGAVTRYEYSENGGLTAVVDAAGGTHRTEVDAVGLPIAVNDARGATTRHLRDAMGRVRQILDPTGGITALSWTVEGKLLDRTHPDGSSESWRYDAEGNEVEHIDRVGQRTRARPTHFDLPAERILPDGSTLQFDYDTELRLVSVTDQTGSVWRYEYDAAGRLVRETGYGGQAVEYARDAAGRVVRRSHGPDDHVEFELDPLGRVLTRSTPTGTSRFRYDEAGRVVWAANGHAETVFRRDALGRVVEESTNGRTLVSRYDAVGRRVSRVTPTGARSDWTYDPSHLPTTLRGGVHTVEFTHDAAGREVGRRFGNAVLAQRWDAAGRLADQDMSIVDGSGAKRRIAHRRYHYRADGYLTAVEEPAGLRTYDLDPLGRVVSVHGPQWSEQYVYDPAGNLTQVGIPGAEPASFTYEGTLLRQAGRTRFDHDRRGRVVRRVRSRLSRKPDVWHYTWDADDRLTEVVTPDQTRWRYTYDAMGRRIAKQRTGPAGEVLERTEFVWDGTVLAEQIESLQAMTWDHDTTGMRPVAQRLRVPTHDAAWVDREFHSIVTDLVGTPAELVAPNGHVVRQEQTTLWGRTAHPATPLRFPGQYHDHESGLHYNYSRYYDPEIARYVTDDPLGIRPSPNPRAYVPNPTRFIDPLGLSPAPGGSHALGTGSHTNPPPPRIPGPISMDEAVELGARHAGDNARVVPSGSGGYQFIGTSTDSAGNRIASVARFDINPASPHVQQLGPHLNLETQVNGNPVRSGPYNDPHIPIDPSTIRPGDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZP1</accession>
    <name>A0A7W7SZP1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DhaL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="7"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="527" mass="53881" checksum="D0FB056646F06272" modified="2021-06-02" version="1">MQALDAGAVRRWADACVRSLDAHRADIDRINVFPVPDGDTGTNLLQTMRAGLDALLRTPADSVGGALTALAKGALAGARGNSGVILSQVLRGLAEAAREASTAGGVALRAALQRADVLATAAVADPTPGTVLTVLHAAAEAARDCPSDDLDAVVTAAAQAGARALADTPRLLPVLSRAGVVDAGGRGLVLLLDTLAAVITGQAVEHVATSASPRTADALTTAREAGSADYEYEVMYLLDGEPDVDGLRHALAALGDCVSVVGDGDGLWTVHVHCTDVGAAIEAGIERGRPHRITVNRFADQVAAPASRFTRDRVIVALVDGVGTARLFETEGAVAHGTDLSDLLSVVTGTRARHVTLLPGDPATRTAAAAVAAQAVDAGQDVVVVPTASPVQALAALAVHDPSRRPGDDVVAMADAAAATRRGEITVSEREAITWVGRCRPGDLLGMVDGEVVLIEPRRADVADLACRLVDRMLALGGELVTALLGEGVPEGLDRELEEHLRSAHPEVELAAYPGGQAGVLLALGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZP7</accession>
    <name>A0A7W7SZP7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">F4559_001296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="26216" checksum="041EC1116DB7537A" modified="2021-06-02" version="1">MIDLNSDLGEGFGIWRLGDDDALLEVVTSANVACGFHAGDPSTMRSVCARAAERGVAVGAQVSYRDLAGFGRRFIDADPRELADEVLYQIGALDACARAAGTSVSYVKPHGALYNATVHHQVQAAAVVDGVRAFGPLPVLGLPGSLLLAEAERAGLRPVREAFADRGYTPDGVLVPRNRDGALLRDTDAVVDRVLGIARDGRLTAVDGTVLTVEIDSVCLHGDTPGAVGHARAVRHALTEAGLTPGRFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1C1</accession>
    <name>A0A7W7T1C1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17049" checksum="2BE9AC79A4ABA18C" modified="2021-06-02" version="1">MTGLPAPIPGPDLVAAWRVFDLVPFDGVPRWAAHWIADGHDGAALTTLAGLSEQDTARVRELLPDAVAECGVPEPTRVEAAGAVFARLALDHVEGRLDRAEVTAWANLVMKLSDYDGEVLGLPLGVLFDFPDLHPYDGYPADRLAEIVREACRKQLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E1</accession>
    <name>A0A7W7T1E1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase SAR1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="663" mass="71461" checksum="BDAF5ED57D3515AF" modified="2021-06-02" version="1">MDYRRWARVTRLTALAGVGGVAVLVVLPVALNAATGGSAPRVLGPYAAWLWPALAALGVMAAVLAAWEPVAARLVRRRPAHPANRVAVLDQVDRHVRDRVEGSLVAQVRLKLGVAPRVAPRLPVRARVPLVVVGEPGAGKTTLLLELAGTLVARARKNPDRPVPVLLDLGRWRPERDFGEWLVRELRARYRIGPRVARHWLRERRFALLLDGLDEVPVRYRAECLAWVTALDVPHVVLCCSTEDYERLPRYDVVRVEPLRRTDVLALITACEPRLDGLAEALTKHPEVWDEVRTPLAFGLLALAYRTGRTEYRGLLDTYVVESAARGPEAPTRTLRALRFLARIARREGDLAARHRLPGRLVWLDFVSPHAVWRLFRRASPASLAGASAALCLVVGARLGLVPAAVVATVGVALNQGRFVERFPGTHGKRWATTGFLLGFGVAGVAATLGAVLGDRLARWPGPVTFAVTVVVAYAVARGLTRDRYWAAACALVPTGVMVWTGPVPAVAAGLGIGLSGVVVGLLTGGLTRVWCDLGRTPGRGPRWLPVAGFAGAGLAALAGAPWGPDAVAPVTGLLVGLAVTPLAARSSALAEVLARPLTLHDLPVRRRALLHTARDRVLLVDGTRFPHVLVRDHLADCDPEELGAHAARRRSRFRPTGYGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M1</accession>
    <name>A0A7W7T1M1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">F4559_001975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20044" checksum="3B50D21FD06082B1" modified="2021-06-02" version="1">MTVQPIRLFGDPVLRTPAVEVTDFDAELRKLVKDLWDTMSDAGGAGIAAPQLGVGLRVFTYHCDGFAGHLVNPTFDVVGDEVQDGSEGCLSIPDLSWDCRRYRSVVARGWNMHGEPVEVEGTDLLARCVQHEVDHLDGVLFLDRLDDETRKRAMAEIRRQDWFDGGLPTLKQSPHPLFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T214</accession>
    <name>A0A7W7T214_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-coenzyme A synthetase/AMP-(Fatty) acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="470"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="918" mass="96690" checksum="FAFE371400FD707F" modified="2021-06-02" version="1">MTLPLIHEAFRAVAGRRPDAVAVVHGDVRVTYRELDAWSDRLSVGLVCGPGSVVPVVLPPGPELVAVLLAVLKRGAAYAVLDPAWPDERLRRVAELLPGQVAATPHPAFPARVAGPALFSGDAAMVFFTSGSTGEPKAVLSPHRGTTRLFDGCTFAEFDESTVMNVSAALPWDAFALELWGVLTTGGTAVLADERPLMPAGLRAAVSVRGVNTVFLTTSLFHLIVEEDVEAFAGLRTVMVGGERLSPSHAARFLEEHPDVRLVNGYGPVESTVFVLSHDVRVADVADEVPLGRPVPHTSVVVLRDGRVCAPGEVGELCVAGEGLASGYLGDDALTAAKFVVVDLPGGPTRVYRTGDLGSVGVDGLFRFHGRADRQVKVRGHRVEPTGIEHLAVVAGVRRAVVVPVRDETGACVALALFHTGHVPGLVDRLRADLPAYSVPDHVVEVEAFPLLGNGKTDTRALLDLLPRAEPGGDGSDAVVAEFASVLGVAVDRDASFFESGGTSLAAIRLCTRLGRRFGRPVPVSRLVRTPTAAGIAAWLASEPVSESGVVDVAELTPMQHGFLVRHLVSGADPENHCPLVWRITGALDADALVAAVSATHRAHGYLSGRYTADEEAVVVPGNREVEFVFSPDLDVELRRPLRLADGVVWRAVLTSVGPSEWLFGVVVHHVAFDGWSQHLLARSLSAGYRGGVVDAGPSPIEAVSASRALVDDLPGQREYWREALRDLPSLVLPPGGDPGPDLVAVPLSGAAVERFSRGRLPVVVDAVARALAAHTGQRDFGIGVPVAHRSSDVLSRVIGCLVDMVCVRVGGDPVAAVEAALAHADVPVAEVSRLVRRGRDPLYRVIVVAQDSPPAELDLPGCVVTREGGHDLGWPMADLLVELDVADGVLRVSRSPLAVSSSTVDAVVKGVVAFLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T225</accession>
    <name>A0A7W7T225_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9232" checksum="5F3D165878D5191D" modified="2021-06-02" version="1">MSFYVLARPDGHASAALVEQTPGQPNLIAEVGDAQIAVQAADHPEGLKLAAGFAWNLAKAATEFATRCQELAMAQDSDAHGRRSRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T277</accession>
    <name>A0A7W7T277_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase specialized sigma24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="26355" checksum="1CA4D58D369B5632" modified="2021-06-02" version="1">MDPTGRHPQNRRTPAEIRREHERRRGAGHTVVDRILGRYHDEFRRRVAVHARRYGIDPAEVYQSACERLLRQSTVDPDHEGLLGWVDNCIRYAALDLLKAARRVPEPRAELPDVPDERWHVAEPGDREWVADLLRSADVTDHQFRLLLLLAEDPATAARELAAALGVKEPYARKVKERAMRKLRTHIGLGSRELNAYLAWHQGRPCTDEDALEKARWKVARFLDGPPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A5</accession>
    <name>A0A7W7T2A5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase/DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="789"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="914" mass="97558" checksum="C4DB431D726C8037" modified="2021-06-02" version="1">MRVSVLGPLSVRTAAGGTVDVRGPRLRALLTRLAVDAGRVVPVARLVDALWPDDPPHDATAAVQSLVSRLRRAVGADAVSSHPDGYRLDAETDAVDFARLVAAGRDGEALALWRGPALPDLPAFAPHWDDLRLTAVERSCADVAELRALCVEHPAREALHARLMRVLHAEGRRADALAVFATARAHLAGELGVDPGPDLREAHLTVLRDDPPRRRLPAPAGTLVGRADDLDRVLASTRRSRLVTVVGPGGVGKTRLALEIAHAADAVVWVALESITADPGAAVLLALGHRTPGMADADPVERLRGARGLLVLDNCEQVVDEIAALVARLLPAARDLRILATSREPLGVPGEALHRLEPLDPDGAVELFTSRAAAVRRDFAVDDDVRRVCRALDGIPLALELAAARLHALTPAQLAERVDDRLRLLDRGPRAGVGRHRTLRAVVDWSWDLLTPPQRDLLAVLSVFAGGTTVEAVVRVADLDPWTALDLLSDLVDRSLVVADGGRYRLLETVREYAAGKLADPAYADAHAAYYLDLAETAEPLLRGPDQPAWLAVFDAEHANLDAAFDRLVEVGDGPGALRLIMARLWWWSVVRGRVGDVRTWARRVEPLTAGPLCALLARGEPDESLWADDRPAVLLALAAARPGIDMVRRIADRLATGDAWSCAAAELARGLGAFELSTGRAVEAEAHYRAALAGFEATGDRWARVFGLACLANVLANRGAAAEALDALLSARGEAAVFGGFEDVLVPMTPMVHIGRLRARTGDVVGAYGELSRAWAAAVRREDRGEQARVLCARAETAWHAGDRAAAVRDFRRALDLAPDGMPAQFLSTLHSGLAVALGGAQAREWHLRATAIVDTTPDGPARAAVWEAYAVWHHERGDRPAAAEALDTARAARGVLALADSRVAATAAWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L3</accession>
    <name>A0A7W7T2L3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5398" checksum="DE138669209AE28F" modified="2021-06-02" version="1">MRIVALQSKQPSTVAPAVVFPPAKFDLVVSTGGRGAARGDLRAGDGGFDVGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2V4</accession>
    <name>A0A7W7T2V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="24866" checksum="374300D6642B2A20" modified="2021-06-02" version="1">MARTVLVTGGGTGIGRAVAARFVAEGDRVYITGRRKEILRDAVSALGGNAHALPCDGTDPEGLAAAVAELPDTVDVLVNNAGGNTDFDLPADEGLAALARRWRANLEANLISAVLTTHAVDHRLVAGGAVVHIGSIAADQGAGSYGAAKAALAAWNVDLAKHLGPRGITTNVVSPGYIRDTEFFRDKLTDERVDHLVASTLTGRAGTPDDIAEAVFFLASPGARHVTGQVVNVNGGAYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2V9</accession>
    <name>A0A7W7T2V9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="24224" checksum="2C978ECDBA304D2F" modified="2021-06-02" version="1">MTRPGQSRTDRVLAEWVWAWALSRGTPDPVVEPDGYRIDVGLPGHRVRYLLPDPDAVGPRAAGLTEPGTWLKVCGPVERVRPALDSRWTIRAPEYLMSVEPATTPPAAPPDSYTVESHRTGDVYDVVVRAADGGHAAKGRLAVRGRAAAVDMVETDPAHRRRGLGSVVMAELSRIASTGGAARAVLVATEEGLALYRKLGWTVESPITAAHLAAGARHEAVIAPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X9</accession>
    <name>A0A7W7T2X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031272938" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15083" checksum="C2F39CE3BAA2E3F9" modified="2021-06-02" version="1">MLKTMKIAAVLTTTAATLVLISGTATAASAPPWVGDPATCTNPLTAVQRTVSGRTVQVRYGNCGGGQYGWGRIQNYTGPDLIRFEVDLNGDRVADDFSTYTAGTRNYTQAYPTSSNPARAFRACFVVASNGTCTADNSTAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T348</accession>
    <name>A0A7W7T348_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="935"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1033" mass="111390" checksum="B6169B3B18232829" modified="2021-06-02" version="1">MSAEQPATAAQRGLWLLDGLHPGSSVYNVWCSVRLTGPLDVAALHRALSGVVARHDALRTTFRATDDGPVRVVADTLDVPLPIVASDDAEALVDAWAEEPFDLAAGPLIRAVLVRIAPERHLLGLAVHHIVCDGRSVHVLFDELARGYAGEEPPAPPAGFGDYVRWQRERETDEDWWVEHLAGAPDLLTPPTDRPRPAVRGTAGATHVFTLDAGLVADLAAFARTRRTSPFMVLLATYSTVLGRVSGVRELLVGTPVSDREVPEFEELIGYFVDTAPLRVDLGGDPTFGDVVRRARDEVFAVLAHPGVPFDRIVERVRPSRDPGHTPLVQTAFSAELEPFATPRFAGLTAELRLPLPTSAKFDLDLMIQRASDGEHFLGVLTYSTELFDESTVERFGQWFTHLLAAGIADPDTPVRSLPLLDRHERDKLLHVWSETSPARAPESFVHELFARSAAATPDAPAVSLDGAETSYADLDARAEGLAAHLRSLGVGPDEVVGVLLPRGLALVTTLLAILKADGAYLPLSPTHPPAYLKRVLDTARVRHVVADPRLAHRLDGVHVVDPSASAPISPQPRRAKPDDLVYVLFTSGSTGEPKGVAVTHRALANVATTMVDHYSLTAADRVLQFANVGFDIHAEELYPTWAAGGCVVLTPDPPPGPEALPELARTERITFTILTSSYWRQWAAKARQDGVHPGETVRLVSIGAEPVDAGTLRDWQRDVGIPLVNIYGLTESTVNATATWLDEPVEGATVPIGVPLAGVEAYVLDDELEPVPVGVPGQLYLGGDCLARGYLGRADLTAGKFVPHPFSPKPGARLHRSGDRARWRTDGRLEVLGRLDKQVKVRGYRIEPGHVGAALTAHPDVTDAVVVVREDRLVAYVVPATVPAGLREHVAGRLPVHLVPAAFVGLPVIPLNANGKVDERALPEPALPVSAPVEASTPAEHRIAAVWREVLRLDRVGVHDNFFELGGTSLTLASVHSRLRDDYGLSMVALYEHPTVAALAAHVATGPTTGTETDLRADRLLAGRARVRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T377</accession>
    <name>A0A7W7T377_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="516" mass="56542" checksum="6F90D7754713A9E8" modified="2021-06-02" version="1">MVWFDDAELRRNAGDTWYSRGLGYVDRVEGLTRSATEVVAAVTGTDEYTVRLWRKGRRLAADCSCPWGQLGNFCKHCVAVGLVALATRPEPESEPEVDLRAYLDGVPREGLVDLVLGLAARDDEVRLLLSRRALGSAGPRPEELYDTVDALRPTSARDLVRVVRAAEDVLGTLETLAVDHPATAAVLARRALANLVSRRLRTKNETLRDSVHDTVTRTVHVLAKLPAADPAEFARWLLGVQRDAPDFPEIAVAGLADALGDEGLDEYGRLVAGPLRDVYLREIVGDVDAKVAEYARGQDAGRYLRIAEELRAVGRNADAASRLRRGLLDATPARRELADALRDLEPGTDPDREAAAGCWAAFEEQPDEFRFRVLLAAAEPLDAVDYARKRAFALLRRRAATEGGRTLVEIMVAAGDFDGAWAAAHEFGCGPVQWFLVARHRARTHPAQAAPIFEYEIDGAIAAKTPEGYRKAAALLVRLRGLHERCGVDFAAYLERLKSEHHRKKALLDSLSSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3A0</accession>
    <name>A0A7W7T3A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA acyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="8">
        <location>
            <begin position="271"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="40421" checksum="7576BAFD6A1E89F5" modified="2021-06-02" version="1">MTTDVYVLDGVRTPFGRFGGALAHVRPDDLAAHVLRALVDRTGIDPAAVDEVVFGAANQAGEDNRNVGRLAALLAGWPTAVPGTTVNRLCGSSLDAVMQASRTIAVGDADLVVAGGVESMSRAPWVLPKPAKGFPAGDATLHSTTLGWRMTNPAMPAEWTVSLGESTELLAERHGIDRTRQDEFALRSHTLAARAWDDGFYASHVAPVPDTDLDRDETVRADTSLAKLGSLKPAFRPQGTVTAGNSSSLNDGASAVLLGTDTAAGRWGTVPLARVAGRGAAGVDPHVFGIGPVEAANVALRRAGIGWSDLAAVELNEAFAAQSLACLDSWPELDPALVNVNGGAIALGHPLGASGGRVLTQLAHELRRRGGGWGLAALCIGVGQGLAVVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3B9</accession>
    <name>A0A7W7T3B9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysine 2,3-aminomutase</fullName>
            <ecNumber evidence="1">5.4.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050066">
        <property type="term" value="F:lysine 2,3-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="52283" checksum="C1E69AC7A734877F" modified="2021-06-02" version="1">MTALHDVEPALQPYAYRRRELVEPDWRRFPGWRDVTERQWHDAQWQRAHCVKNPRQLRDVLGDLVDDAFYADLAEDQARHATMAMLLPPQMLNTMDPGAFREDPVRRYMLPVASDRAAWPSHPRSSRDSLHESDMWVVEGLTHRYPTKVLAELVSTCPQYCGHCTRMDLVGNSTPQVDKQRLELKPVDRQDRMIEYLRATPAVRDVVVSGGDVANVPWPRLESFLMRLLAVDTVRDVRLATKALAGLPQHWLQPTVVEGLERVARTAARRGVNLALHTHVNHVNSVTPLVAKAARTVLDVGVRDVRNQGVLLRGVNATSTDLLDLCFALQGEAGVLPYYFYLCDMIPGAEHWRLALWEAQDLQLAIMGYLPGYATPRIVCDVPYVGKRWVHQVTAYDRERGISHWTKNYRTTLDHDDPDALTRRHPYYDPLPTLPESGRRWWSDQSAGFDQRSVNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3D1</accession>
    <name>A0A7W7T3D1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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</entry>
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</entry>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2118"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2240"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2733"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3225"/>
            <end position="3244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6394"/>
            <end position="6414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2130"/>
            <end position="2158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="7049" mass="689821" checksum="67743CCA2D2F4189" modified="2021-06-02" version="1">[encoded data, 7049 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T483</accession>
    <name>A0A7W7T483_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10806" checksum="6C61085644A3E368" modified="2021-06-02" version="1">MEERVRALVHELVVLISPVHDPEILVRLWVLESVSRAVREMGDLEVLRAREPAPAVGHGGHTWAEIGSALGVSSQAARQRAERRRQTLHRFDGGTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T487</accession>
    <name>A0A7W7T487_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="36525" checksum="76ED857C2D38D661" modified="2021-06-02" version="1">MTVIDDHAAGKASGTWWGDLIRVLDAVRPGGSVAATVDDVAELLGLTVIRGDTPTPEPPEPRPSDPSAPPVAESGPAEDLSVPPLPPELSGRQAARNDRERTGREHNEEEVVGGALRRQWREEPPPMPWTEADKLGTATVDRLRRALPHTPLLRDGVLAGIVGALVARPVADGEIDVERLVEVLAHGRPVAVLPRRVRHSLRFGAHLLLDRGEAMFPFRRDQDDLEHAVGAVVGRTSRTTARFVTSPFEAGKEALPQRGRPVLVLSGFGIGGAHADPADWARYARRVRSRGSRLVGLVPFPEHRFPGWLRRTMPVVTWDRSTTVGAVHRAVARRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B0</accession>
    <name>A0A7W7T4B0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="470" mass="51790" checksum="8A56B415C548C03F" modified="2021-06-02" version="1">MTVIGAGIAGLVGAYELERRGHDVEVLEGSGRIGGRVYTHRFSSDSGAPSVELGAMRIPVEHRHAMHYITELGLADKVRVFRSLFSDDGAYCATGAGHLRVRDAARALVDDFRRAVPERRYADDSVLFGAWLMAAGNAIAPADFRTDLRRDLWLDLLDAVERVDLSPFLRHDRVDLHAFFALHPEIRMTGNGRLDRFLHDVLSETSPDLVRLAGGMDQLAHRLAGRLRGPVVCGQEVVGLTVREHDVLVAIRDGDQFRTRRCDYVLCTVPFSGLRRMWLSGFSRSKLEVIRDMTYWGATKVAFHCREPFWEQDDIGGGATFAGGLVRQTYYPPVEGDPAGGAALLASYTIGADADVVDRMPDSVRHAVVLQELGRIHPELLRPGMVLDAVSLAWGRYWWSGGAASVRWGLDTVAGETERVRAAEPENRLFFAGEHCSSTTAWIEGAIESAVDAAREIDAFTARARLVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F3</accession>
    <name>A0A7W7T4F3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27255" checksum="BE6689014C35641E" modified="2021-06-02" version="1">MGADRAVVFVHGGGVTRDEGGFFTRLAAGLGEAGVASLRFDLRGHGESEGHQEELTLSTILNDISAAVDRVREVTGVEAASLLGASFAGGITGYYTAKRPDEVDRLVMINPLLDYRKRFVDDKPYWTDGRIDDVAGRELADRGFVAHSPTFRLGRALLNEVFWLKPGEVLSEIARPTLIVHGTRDTFIPVESSRAAARTLRAEHRLVEIEGAQHGIAVHDDPRYLDPQTREWQAFTIRTVTDWITGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I1</accession>
    <name>A0A7W7T4I1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="22280" checksum="CDFA9856FB30A401" modified="2021-06-02" version="1">MPRPSRAHLKRGELITAARQAVLERGVLDLRLRDVAEQADMSTGSVLYYFPTLGDLLYEVQREAVERFCVDREEAARAEPDPRRKLVVTIRAGLPTGQDDELCVLIYELGAYARRDPAYAAEHIRLYERQVALYTAILEAGTATGLFDPVRDTTTIARGLVALEDGLGLHITQAVPTFTTEQAEAMLVAYAADATRCELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K1</accession>
    <name>A0A7W7T4K1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T5orf172 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025280">
        <property type="entry name" value="DUF4041"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13250">
        <property type="entry name" value="DUF4041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="3">
        <location>
            <begin position="312"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="435" mass="48035" checksum="795CFF636D1B7E8E" modified="2021-06-02" version="1">MFNRDSAEAAALHQRLAGAEATVNELRAWVGHLRGTDAAVLEGELRALRSAVERTKGEVAALAAEKRRAEAEAAALRALVVETRETALLQEVGIYEYAHPLQDALAYKDALAALKQRIDAMAKGGQAVTCQVDWTVNGSRKDGDKLGRDMAKLMLRAYNAEADNAVRTVKPHTREKVKTRLTTTRDTIGRLGALMRVTVSADYHRLRLHEIDLTTDHLVKVESEREAAREERARLREEAKAAKEIERERARLAKERAHRASVVARLEAKGDTEALAQARLELAAVDDAISGVDERAANVRMGYVYVISNIGAFGPDVVKIGMTRRLDPMDRVRELGDASVPFRFDTHALFFSKDAVALETALHRRLAHRRVNVVNPRREFFRATPAEVRALLGELDHDAVLEYTETPEAAEWRASGAHLPADPDADGDLSDDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S8</accession>
    <name>A0A7W7T4S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12733" checksum="E958B85E23CECB5B" modified="2021-06-02" version="1">MIDGGLREIFGEDARIFLKADPLAGLVAASLYVKEGTVPARVMDVWRRELVVGRRTVENSEVVFIERARAQGYTWELIAEELGIDDAERHLEDLKAALERSHPGRNPRPYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C6</accession>
    <name>A0A7W7T5C6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16838" checksum="0541450352D77BA6" modified="2021-06-02" version="1">MAEPPSLGELTPEEIERWTRAAETNAANLRTVADRVAAVRVTETSRDGLVRVTVEPSGAVSGLEISDRCRGMSGAELSAAVLATMRKAQSRLAGEVSGVVQGTVDGDTATALVASYEQRFPEPEPDSPPWADQVRPSTPARPRRPAADEDWDGPQVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T602</accession>
    <name>A0A7W7T602_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030882189" evidence="3">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="19869" checksum="53F15B7F7C52B427" modified="2021-06-02" version="1">MRSTGIVLCALLITWAVSLSPASATPTRNAFTLSSTAFADGGTIPKVHECTSGGGNDPAKKNESPPLAWSGAPAGAKSYALIMRDIDNANLIHWVIYDIPVSATSLPQNVQHVYQPPVPAGSRQIYYRGSASLYGYQGPCSPSTVNTYDFVVHALNKASLTNLNNNSSTQTAARAITAASIGSARITGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T633</accession>
    <name>A0A7W7T633_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33114" checksum="C3F2D9790A31A357" modified="2021-06-02" version="1">MTTPAIAATGLRKAYRDNVVLDGIDLEVAAGTVFALLGPNGAGKTTTVRILSTLIRADGGTASVAGHDVTTDADAVRRAIGVTGQFSAVDDLLTGRENLLLMADLNHLGRAEGRRRVADLLDRFDLVDAATRAASTYSGGMRRRLDLAMSLIGDPRVLFLDEPTTGLDPRSRRTLWQAVRDLVAAGVTVFLTTQYLEEADHLADRIAVLDGGRIVAQGSADELKRLVPGGHVELRFTDLATLDTAARALGEVARDEDSLVLQVSHDGGVRALKTLLDRLDDAAVDVEGLAVRTPDLDDVFLALTDKESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T635</accession>
    <name>A0A7W7T635_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="34"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="34732" checksum="994C4E7B7F61164E" modified="2021-06-02" version="1">MNTRLTWAPAEIGPSDVGARPTAAGLIEYLEGATDLDERLVAEKALVFRGFGVTEDTIAGVMDRLLPNRLAYVHGNSPRTKVGSNIYTSTEYPPEFTISMHNELSYAHSWPSRLLFCCVLADMTGGATPVVDAQLWLESLDDDVREAFAGGVRYTQNLHGGFGLGKSWQDTFETDDREVVDEFLRSTEATWQWHDDGGLRVSQLRPSTTKHPVTGAEVWFNQADQWHYATLGDETAKAMAEVLRAEEMPQSVTFADHRPIPAEYVLQVRDRGLELAVDVDWRLGDVLLIDNLLVGHGRRPFQGSRRVLVGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A7</accession>
    <name>A0A7W7T6A7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding Zn ribbon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20665" checksum="8D034D215E2A2F28" modified="2021-06-02" version="1">MTRQPGDRAAAPGGLTLVQSFVNSINVEFGPDEFATTEGLAHWLGRNGFPDARPDDLDRRDAVALREALRALLRENNGVEPDPEARRTFEHIARACPLVLRCDPTGAIGLAPAQNDVRGAFGTVLARVAEATVDGSWQRLKACQEHRCEWAFYDRSRNRASRWCSMAVCGTRAKMRVYRQAKRGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T702</accession>
    <name>A0A7W7T702_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="2">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="9">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="551" mass="60956" checksum="617E192E13CA279F" modified="2021-06-02" version="1">MSGITTPTKRQGAGARLAGGAAKWADDRFHMAGGIRKQLNKVFPTHWSFLLGEIALYSFIILLLSGTYLALFFDPSMEEVVYHGSFVNLQGIEMSRAFESTLQISFEVRGGLFVRQVHHWAALLFMAAIVVHMFRIFFTGAFRRPREINWVIGIVLFMLGAIEGFLGYSLPDDLLSGTGLRVMAALLISFPVIGTWLNWLAFGGEFPGTEIIPRLYTLHILVIPGIILALIAVHLGLVWYQKHTQFPGVGRKETNVVGVRIMPVFAAKGGGFFAVVTAVTAIMGGIFQINPVWNFGPYNPAQVSAGSQPDWYMGWTDGLVRIWPAWELYLGDYMIPAPFWPFMLGLPLLTGIAAAYPWIERKMTKDYAHHNLLQRPRDVPVRTSLGVMAITYFMVLLLMGANDIFAYKFDISLNATTWMGRIGLLVLPPIAYFLTYRLCIGLQRADREVLEHGVETGIIKRLPHGEFIEIHQPLGPVDDHGHPLPLEYQGASVPKKMNKLGSAGHPVPGSFLTPDKPEETAALARARAEHGAATDSLTAENKPALPGKHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H4</accession>
    <name>A0A7W7T7H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="17229" checksum="A5F34A15819FC23B" modified="2021-06-02" version="1">MTTTEQFTAPTTPPPATPKPKASRLRTGLVAAAVALAVAAGGGIVYAVSGQSASSSQVGQAPGNFGNGQAPADGTGGGMGGGMGGGMGGGMGGGLPEDVTHGVLQTGKITEVTDTSLTAESTDGYTRTYVIDADTVFAAGRETTTAADLATGDTVSIIARTEDDTTTAVRVTETTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7J3</accession>
    <name>A0A7W7T7J3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23412" checksum="D3912990A0AEDB70" modified="2021-06-02" version="1">MRVRVLVADDQDLVRTGLSMILDARPDIEVVGQAADGHAAVELAHRLRPDVCLVDIRMPGLDGIEVTRLLAGRGVPDPIAVVVITTFDLDEYVHGALRAGARGFLLKDAGPELLVQAVHAAAVGDALIAPNITRRLLATLAAAQPPSRQPQPVEPLTEREEQVLALVARGRTNAEIADELFIGLTTAKTHVASLLTKIGARNRVEIAMWAHDTGRVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T880</accession>
    <name>A0A7W7T880_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DivIVA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11889" checksum="4C9C20C29EDD8649" modified="2021-06-02" version="1">MTTALIYLVVMVLVAAVVFLLASLVFGRGEEMAPLPPGTSPTRLPADDVRPEDVRAVRFQQVLRGYRMSEVDWVLDRLAGEIEVLRSRVAELEADREPDAVRPAGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T893</accession>
    <name>A0A7W7T893_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24297" checksum="A348CA8FC492C167" modified="2021-06-02" version="1">MADAGVIDRYLADLDRRLRGPGPVKGDLLAEARDSLADAAEAYRAGGVPEAEAQRLAVAEFGPAHVIARDYQSVLALAQGSRTLRAMLFAVPLMYSIWGLNQVFWIGEWPPLPGGVMPDWYRVIAHINDRIGWIAAATALLTLVASRYLARRGTSTEALGRLTGSVSVGMVGLALFCNVSIMVATLHLDPERMMSSPPMTSASLVSLLVLGRLMVLARRCFSFASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8F7</accession>
    <name>A0A7W7T8F7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding transcriptional regulator AlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7507" checksum="594D916EECE58CD2" modified="2021-06-02" version="1">MAGGIMAQVEPLWSVDEVAIFLGVPVKTLYQWKWRRYGPPVRKVGKHLRYVPAQVRRWVEEDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G6</accession>
    <name>A0A7W7T8G6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA-[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="18584" checksum="DCE8451C11E08188" modified="2021-06-02" version="1">MTAYVSTVDTPIGPFTAVVAADGAVLASGWTGTTDDLLPRVSPSLRPTALTTRRDLGRVTRAVRDYHAGDLTAIDDVPVRQRAGDFMDRALAVLRDVRAGEPVSYAEYAGLAGRPSAVRAAASACARNAATLFVPCHRVIRSGGAIGAFRWGVDAKRWLLNHEAPGQDGSASRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I9</accession>
    <name>A0A7W7T8I9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16396" checksum="319337A7D1919198" modified="2021-06-02" version="1">MNPLTGVAQSVLVAVVVGVATVFGINHMGASLFWSVVIAVPVAALALLGARLPRAADVHWAPPPVHHSSATTVQASTLATRLAEAAVDPDRFASRVQPRLRRLVEARLRQRHGVPDLADPRAVALLGPELHRLVTAPDATLPDPKRFAELLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y5</accession>
    <name>A0A7W7T8Y5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27085" checksum="F41C396AA221615A" modified="2021-06-02" version="1">MAERSGAGGRRLGRNFNYQEWAAGGFRFAEPDADPQDEEADDAPHSWPGRAERAEMPRVEGTGQGQDDMSQREVDDSSYDYDDVPNRFDIDGYGSGLFGGPGADLFGAHGLPDSVPEQLPYTTGPQPVIRHEENPAAESGSLVRPYTRTGGRTRPDYDLAIEALVSTSERGLERDAAVLPEHRSICGLCTDTRSVAEVAAHLRLPLGVVRVLIGDMASMGLVLIHQGGLVVGDRPSIDFLERVLSGLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T925</accession>
    <name>A0A7W7T925_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="18808" checksum="6879B72EC82C0494" modified="2021-06-02" version="1">MTDLTRSMLDAAAGLIAAHGARGLRMADVATKAGVSRQTVYNEFRNKGRLVQAVALHKTAEFVDGLRERMAGCADPVDGLRAGFGFAFDLAASDPLARSVLGGAHAEDMLPMLTTRGRPVLDLATAAVAAHVREHWPLLTPERTALVADTAVRIAISHLLTPATCGVESVVEVTVSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T961</accession>
    <name>A0A7W7T961_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP cyclohydrolase I</fullName>
            <shortName evidence="5">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">folE</name>
        <name evidence="7" type="ORF">F4559_006246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="27"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23147" checksum="C3EC5F652BD31376" modified="2021-06-02" version="1">MTGTEHADPATNGEVGARRVFDQKRAEAAVRELLLACGEDPDREGLRDTPARVARAYRELFAGLYTDPSEVLSKTFDESHEELVLVTDIPMFSFCEHHLLPFHGVAHVGYIPNEHGRVTGLSKLARLVDLYAKRPQVQERLTSQIADALVRRLEPRGVIVVVEAEHLCMGMRGVRKPGSRTTTSAVRGLLRSSASSRAEAIELIKGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T966</accession>
    <name>A0A7W7T966_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037783">
        <property type="entry name" value="Taf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="PTHR19879"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="653"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="745"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="791"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="835"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="881"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="927"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="965"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1302" mass="138758" checksum="F1A72773ACCED363" modified="2021-06-02" version="1">MASPDRGAGPRAVFAERFALLYAEAGDPPLKRVTESVGRARRLDERGRPVRATAQRVSDWRRGRNVPARFPALAVVLEILIGEARKNRPPSIPDLYDLDVWRELWEAALASPALRPEDEPPSTDEIGVCPYRGLAAFQAEDSNWFFGRERSTAALVDRLRAAALDGGIAMLVGASGAGKSSLVRAGVVPAIGRGALDLPGSHDWVTVVVTPGADPLKELLRRVPELVDVDDESPEQVRAAFARHVARTGGDRVVVVVDQFEEAFTLCPDDDAVRTLVRVLHAASGGPAVVLLGVRADFYGRCLDYPELADALQHRQLVLGPMTSAELREAVTRPAKAAGLVLETGLIDLLCRDLGVRDGRSGPGGAYDAGALPLLSHALLATWQRRQAGRLTIAGYRAAGGIQGAVAATAERAWADLAAPAQAAARPLLLRLVRVGEDSQDTRRRATRADLVGHADTPAAVEEALEVLARARLVTLDAGSVEITHEALLQAWPRLRTWIDQDRAGQLLRQRLEEDATTWHAQHRDTSLLYRGARLENARTWADSAGRTALTAVARDFLAVSGQHRRRNAFVRRGAVVVVAVLAVIAVTAAVLAVRQRDDAVFRQVVAEADRLLDSDPSLSAQLDLVARDMRPDDHDVHSRLLSTQGTPLATPLVGHQGAVYLTSFSPDGRTLATASYDKTVRLWDLSDPDSPKPLGVPLQAHKGWVSSAVFSPDGRTLATAGEDGTVRLWDVADPMKVRSLGEPLAGDNGTIYLIAFAPDGRTLATANADKSARLWNVADPTAPVPLGEPLRGHADQVRAVAFAPDGRTLATTGDDGTIRLWDLGATPAPLGTPLTGHDGIVHSVAFSPDGRVLASGGEDRTVRLWNVVDPHAVTPLGRPLADHAGAVWSVAFSPDGRVLASGGADGAARLTNVVDPTRPLPIGRPLTGRNGTVFAVAFSPDGYRLATGSQDTAVRLWSLPRTVLIGHSARTTGPVFTADGRRMVTGADDTTVRVWDTADPTAPTSSAGTVTSTGEVVWALTADDRTLVTASDRHVRLWEFPAAGTPRPYGPPLELETRYTSTIALHGDLLATGWTDDSVQLWDVRDRSAPRRVGAPLVGHGGYVHFARFTPDGRVLITGSADHTLRLWDVHDPAAAHPLGRPLTGHTGAIRDGDVSPDGRVLATAGDDKTIRLWDLSDPTAVVPLGGPLVGHVEAVVGVAFAPDGRTLASGGEDGAIRLWDVAARTAVGQALTGHTGGVREVRFHPDGRTLVSTGVDATVRVWRLDLGQVAARICAKTKGVLPEDVWRRHLSQLDYAPPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T990</accession>
    <name>A0A7W7T990_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="281" mass="29361" checksum="68DA49D3E4BD41AD" modified="2021-06-02" version="1">MPGRNPTRTRPAAPGSAESRPNRTGPRPVAPDSATPGVPAPAVRTATDPIPADPGRPAAAAPAGLRPNAPDPDAAARRATRRRPIVPRLGVAAAVPSAGSRRPGRVPAARRAAYRSAGPDQVPKARRAADRSPDPGRLPAAPHAVSRSADHGRTPRAACRSADPDQVPKARRAGYRSSDLDHPDEDRSQTGPFGPRQPLPGVRSVSKWSPSALRRQGPHPSARAAGPSGSGSADRPVRVVRPAPSATRPRGRRRRRSATSGRRAHSPPRSITGNVTYINEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P8</accession>
    <name>A0A7W7T9P8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tachylectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023294">
        <property type="entry name" value="Tachylectin2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14517">
        <property type="entry name" value="Tachylectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tachylectin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="662" mass="71234" checksum="9558CBB354A556F9" modified="2021-06-02" version="1">MAIDSEQSQLRMVPGGNGVFYSVQADGRLLRFRHSGWQVGTFDWENNGVGVAIGTGWHVYDTVLGAADGQLFGITGDGAVHWHRYDAVAGRWAPNSGAVIKTGLGGYPTVFGGWDGVLYAVDGDGRLFWFRYTAGNGSSGPNAWAGGGEPLPIKDDVRLYLQYLADQQGVVYAVRQGGGLDWFRHLGGGNWANGGVPIRVGSGWTTDDQREISAQGGSLYSVLIDRSSEPGPDHELNWYRLVNWLDPAGGPNWANGGTGRRCGVGWTTCRTANLQGYATSWSVRSGASLGVKVSSTFDSFQASVRRVEGPLPEGGTTVWGPVTTRGRLQLLPPGYRRSGCGWADSVTVPVGTSWPSGLYTVVLSGPSGLTRTIPFVVRPTTPAARLAVLIPTLTHNAYNSWGGHSQYTWDNVPTHRYVTTRRPADNAVLRPPGRVDARWFSDLLLLRWLKRNGYAHDCYQDLDLHHDPALFDRYRAVVLCTHPEYWSAGMRDALGRYLDRGGRVVSLGGNVIYEPVSTTDDAVIVHRDAAGARTPWAALGKPAWELVGTAFTDESYLTFEPYKIVSAHPFLTGTGLSVGSTVGADGYNFAAAGWEMDASPANLPGLQVIARSPQPGGAEIVQYRRTGGGWAFSVGSLSFVGSLDRDTALTALVRNAIDAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R2</accession>
    <name>A0A7W7T9R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase (Regulator of RNase III)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16194" checksum="7A99E496E8FE17F2" modified="2021-06-02" version="1">MLDIPAEAVVSPANSSGWMRGGIDAVYARAFPLVEANVRSAVLALHGGELPVGEAVLVPTGEIEPQWLVSAPTMRRPAETLPDDTVHPYLAARAVLRLWRDGRLEDGRPIRSVIRTLVMPGLGTGIGGVAPGTCARQVAAAWDEVFSPLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T4</accession>
    <name>A0A7W7T9T4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="72"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="421" mass="45377" checksum="EB8F32F1EE1C529A" modified="2021-06-02" version="1">MNAGYTAHDAERRTEERPKAALLPDAVEELRTPFARDRARVLHSAALRRLAGKTQVVGPGEGSEVTGVPRTRLTHSLEVAQIGRGIGGTLGCDPDIVDTAGLAHDIGHPPFGHNGERALNAVAADCGGFEGNAQTLRILTRLEPKTRTGLNLTRACLDAATKYPWARRPGTVKFGVYQDDLDVFGWLREGAPEGRRCLEAQVMDWADDVAYSVHDVEDGVLAHRITLAALGDVTERRAIADLAARHFSPEPVAALEEVAADLLRLPVIANLAEYDGSLLAQVNLKRLTSELVGRFASAAVGATRREHGDGPLRRYAADLVVPPRVAAEVALLKAVAVRYVMSDPVHLERQARQRELIGELAETLGKGAPDTLDPALRPAFESASSDADRLRVVVDQIASLTDAQAQAWHRTLVRGNGHTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U0</accession>
    <name>A0A7W7T9U0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6389" checksum="186919D856B74A81" modified="2021-06-02" version="1">MPAASHVLKAHRVAMAAHSFAAGRRSGGEGGTRHDVVIPERRTRTEPDGSGARARGPVASAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W6</accession>
    <name>A0A7W7T9W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10690" checksum="061AC2E4AC06D9DA" modified="2021-06-02" version="1">MIGYWLNAKRRGALKSARMLDEVVDTQLPLLAAFDEERRRRSADYLAELVKLAGAYRGYARGWIDARELERRGGLVMTELHRLRAGSAARLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA98</accession>
    <name>A0A7W7TA98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="517" mass="57861" checksum="68185E5AB6E08BFE" modified="2021-06-02" version="1">MASPPQLKQANADDTDSLTPEERAYPTWTEPLAQSGSRPFGGPAGRHATVGRQWFWTPLRVVLLLSVLTLVLSWFQKSPCIQQYVDGNGQVQLDWRESRQFVAMCYSDTVPLYTAERLDQPDMFPYKTSWVDDQGKPTEHVRYMEYPVLTGVFQWVNARMAQGWTVIAESGFLPKPMTVITYFNITAFWLALAWLVTTWAALRIARRRPWDAALVAVSPLVVVHAFTNFDTLATAFATAAMLAWARKKPLVAGILLGLGGAAKLYPLFLLGPLLLLCWRSNRLKEGLATLIATLATWAAVNLPIFLRYPDGWREFFRLNTERGVDPDSLYNVVIQWTGWEGFDPGLPYGQAPEVLNTVSAALFLVCCAGVGFIAMTAPTRPRFAQLSFLVVAAFLLTNKVWSPQYSLWLVPLAVLAIPRWRLLLAWMAVDAFVWAPRMYFYLGVDNKGLPIDWFLGAVVARDIAVIVLCVLIVREIYDPAKDLVRQAGDDDPCGGFIDGAPDRFVLRLPRRKATVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAD0</accession>
    <name>A0A7W7TAD0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025758">
        <property type="entry name" value="Fic/DOC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026287">
        <property type="entry name" value="SoFic-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13784">
        <property type="entry name" value="Fic_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038925">
        <property type="entry name" value="AMP-prot_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="131"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="260"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR038925-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="43464" checksum="002AE26DEA9C3286" modified="2021-06-02" version="1">MKPEAFQAPQFGRVTKKPGDKWAFWYFEPAPVPRELVMEPKTILALSKADAALGRLSGVGRLLRDPSILVHPYLTREAVASSRIEGTEASLSDVLKAEAADDIPENDDIEEVINYQRALREGMKLLEKLPISRRFVREVHKVLLSGVRGQEKLPGEYRKTPVWIGSPTDSPDTATFVPPLPDLLDDVLSDWEKFINEEASLPILAVCALMHYQFETIHPFLDGNGRIGRLLIILLLMEQKVLELPLLYVSAYMEDNRREYYDRLQAVRERGEIQEWMQFFFTAVYRQAVDAEERAGRLVELREKYREQLRGTKSRAAEVVDLFFSNPFITVKRVQGALSVTNQGARNLIDSLEEKGILRKVGTVGRGGRIYWVAEQVHDAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH1</accession>
    <name>A0A7W7TAH1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="33437" checksum="7CE308EE5691F425" modified="2021-06-02" version="1">MRKRGLLLSGIAAILVTVATIVVLLLVDPRTGLGEAIKTGGLAGGSIVALYALWLNDRRRRTEEARHDLESVKIADERFARAVEMLGHDADQVRVGAMHALANLARTTPRYKQTVLDVLCAYLRRPFTHEAFTTTPADPDQSGVEQGDQDRERTVRLTAQRLITDLLPWGMDTDPVLYHLDLTGANLEYLRLEGRRVGRLTARRARFHGITAFRGATFGKPVLLSGAIFHGRLDLREARFDGGIAFTDTTFSGRVELSDATVGTFLALAPEPPADVRGTLTLGADVALRTPDQGWPLAKPAGDEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAI3</accession>
    <name>A0A7W7TAI3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="28099" checksum="B17AFDBB8DE328A1" modified="2021-06-02" version="1">MGTADPRRSLFVCCDLRSYGAADDGLQRELQELLVGSLDRAGAAAGLDRSRWTRQPKGDEEWAVLPSTEPERRVVDDYVRALDRELSAVNKWRVPAGRLRMRLALHHGVVVEGANGFPGQDPVLVSRLLNCSAARRALEQFPEAALVVVLSDHLYSSMVRPGHTTLRPEDFRRIDVVEKTFTGQGWLWIPNGDAHALILEERDSDQGRVPAGQHATATGGSTVFMAGRDVAQHAEVIQNFSGNDQRGSHFGTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBD6</accession>
    <name>A0A7W7TBD6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21447" checksum="E39E1F4B94D7E7EA" modified="2021-06-02" version="1">MREVPSRPGKADVDSILSDLGDLRLVVAGTDADLNAVVLRLLRTELLGEVPVGYVPLEEDSAVADLWGLPTDPGRALDLALAGEPDPVPLVRDDVGGVLVGRGVLGPVRGVGYADDTVVLRGQASRLEVRPDRELGLVVSVIHKRLFGNRVRETAGRAFQLGCLPLHVVSDGITHPRALNKWTWYRHTEDLRLVRGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBK8</accession>
    <name>A0A7W7TBK8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.19" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043799">
        <property type="term" value="F:glycine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="33998" checksum="D2C1CEEA9EB7358C" modified="2021-06-02" version="1">MTTDVTVLGGGVIGLSVAWTLARADYAVAVVDRGSRHGGSHVAGGMLAPITEAWPGDEDVLDLGVESLGLWPAFAADLGVPLSPVGTLAVGVDGADTAVLDQLCGYLAARGRAADRLTGRGLRALEPGLGTSVRSGLSVPGDLSVDNRVLLAALRAACAGHGVRFVDGADSPVTVIAAGAWSRDLHPALRTVIRPVKGEILRLSTRPGALPPPRHTIRAHVEGRQVYLVPRADGIVLGATQYEAGFDADVTVGGVRDLLRDGEVVWPGIAGYALAETAVGFRAGSPDNAPVVRWLEPGVLAATGHHRNGLLLAPVTARRVLELVGEGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTA5</accession>
    <name>A0A7W7WTA5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purN</name>
        <name evidence="5" type="ORF">F4559_000349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="3">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="20567" checksum="856BBEE88609C8AF" modified="2021-06-02" version="1">MVVLVSGSGTLLQAVLDAAAAPDYPVEVVAVGADRTGIAGLDRAERAGVPTFAVRLRDHADRAAWDTALADAVAAHEPDLVVSAGFMKILGPSFLDRFGGRMVNTHPALLPAFPGAHGVRDALDYGVKATGATVHLVDAGVDTGPILAQEAVVVDPDDDVDSLHERIKVVERRLLVDVLARLAREGCTVDGRKVSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTA7</accession>
    <name>A0A7W7WTA7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="9" type="ORF">F4559_000243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="22644" checksum="21EAED24829C0101" modified="2021-06-02" version="1">MSDRQVKGLLGTKLGMTQVFDENNRIVPVTVVKAEPNVVTQIRTQENDGYSAVQLAFGAIDPRKVNKPVAGHFAKAGVTPRRHLAELRTTDASEYQVGQEITAEVFEAGAVVDIVGTSKGKGTAGVMKRHGFAGLGSSHGTQRKHRSPGSIGGCATPGRVFKGLRMAGRMGHARVTTQNLKVHKVDVESGLLLIKGAVPGPKGGTVFIKTAAKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTS5</accession>
    <name>A0A7W7WTS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="36948" checksum="B3812A6B40F81025" modified="2021-06-02" version="1">MLARELADSPELAPLHDAYTEYALRDRHLPRPVLAYFGFHAFADAVDYSDVDRIGEALIVPQLLRDVLAIHDDIVDEDLDKFGAPPLPVALSGAEGRLTRRGKDLALYYGDFLVGVLHRVASGVPGEAGRSLVRLIADTLYVNQRGQLAELLAETKPLAETSVDDLLVIGERKAAHYCYSFPFRVGAVLAGHDGRRIEPVCRVLLKIGTASQVVDDITGTFPGVVDHDKDTLGEIANLRRTVPLVLLATGRHSERAAALLAAPTPLPPDDAARLREELWCGDVPDRALTLGRGLVDDITTGLARLDLGRAAARYLDDLVAYRLRDSLDRFERAIGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT0</accession>
    <name>A0A7W7WTT0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8974" checksum="A3BB4F4CD3F0258A" modified="2021-06-02" version="1">MARPARLNAGAAQFGGGGRAEAFDNLRHADMSTMDDDAATDLWNSGGRHDYDHIQRTTGRFGNEHYFRNTIYHLFANTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV3</accession>
    <name>A0A7W7WTV3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33738" checksum="3A217B5F07C991B9" modified="2021-06-02" version="1">MIRIPQGLHGAHLRDRLLDHLGRAGLRDALREGRLVSYSRAVVVQRELVTDPHTRAAAALLSAGPPALLTGRTSAWLHGCTAASTDDVHLLLGYDHQYRPRQGEVRHHANYDASAVVVIDGLRCHAIVPTLGDMLCRDDRAMAFTCTNEVLAALDPKDRAGFIADVDVHIARRPDSRGRRRGGFLLDLATGEPESPAESRTLLLLVDEGFPVPRMQYPVCDLDGRVLWRLDFAWPDRRLALEYDGYAAHVDRVEADRARDEDLRRRGWRVVHADASDLRRPARLIECLSAYFAVSERTTRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX2</accession>
    <name>A0A7W7WTX2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">F4559_000948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="44326" checksum="96034C1073F59BB5" modified="2021-06-02" version="1">MSEHFRVKGGARLVGDVDVVGAKNSVLKLMAAALLAEGTTTITNCPEILDVPLMADVLRSLGCEVTLEGDVATITTPKELDHRADSEAMGKLRASVCVLGPLVGRCKRAVVALPGGDAIGSRPLDMHQNGLRKLGATSEIEHGCVVAEAQGLHGAQIWLDFPSVGATENILMAAVLADGTTVIDNAAREPEIVDICTMLVEMGARIEGAGTSTLTVHGVTELKPTTHRVIGDRIVGATWAFAAAMTQGDITVRGVDPHHLDLVLEKLRTAGAEVTIVDGGFRVVQRDRPTSVDFVTLPYPGFATDLQPFAIALSTVSDGTSMITENLFEARFRFIEEMVRLGADARTDGHHAVVRGIERLSSAPVWASDIRAGAGLVLAGLCADGVTEVYEIFHIERGYPGFVENLRRLGATVDRVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU28</accession>
    <name>A0A7W7WU28_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P27 family predicted phage terminase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006448">
        <property type="entry name" value="Phage_term_ssu_P27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05119">
        <property type="entry name" value="Terminase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01558">
        <property type="entry name" value="sm_term_P27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="16475" checksum="749F6B6DFFA92D03" modified="2021-06-02" version="1">MPTAVAELNGYRKDRINHDEPVPAAGEVEPPAWMVAVHQLADDGEESALQVWRRLAPDLIAKKVLTPWDVEAFAVYCTSVVGYRRAAIEVAVEGMTTRGSQGVVKNPAVTAMKDCADLMNRYGAKFGLTPSDRAALAIKPDEGKGKGAERLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU55</accession>
    <name>A0A7W7WU55_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-degrading monooxygenase HmoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="12125" checksum="5EC430518BE33D5E" modified="2021-06-02" version="1">MVFRVQLRMEIKPGHEADFERVWREIGDAVTGHPANLGQWLARSLEEPGIYYITSDWVDEPRFRDFETSEGHLRHRTRLHPFRSGGSMTTMTVVAALGGGRSRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC2</accession>
    <name>A0A7W7WUC2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10301" checksum="D578E44021C1C957" modified="2021-06-02" version="1">MPATPTTTTWRTSSHSGEGPSCVEVAWRTSTHSGNGASCVEVGWHTSTHSANGQSCVEVTPTNEQVLTRDSKNPTGPALSFSTTEWRRFLHTLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP7</accession>
    <name>A0A7W7WUP7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21341" checksum="3BD2E1457E681667" modified="2021-06-02" version="1">MTPQLFDGLVYRLLVAVDVEGYSRLDALEQSRVQSRLGEVLDVAAADCGLDRSGWYRQPRGDGELAVLPADVDTAWVVGAFTDCLASALAGLRTAGTPLRMRVAMHCGPLIPGRFGVVGDAPIVTSRLLDAQVVRRTLAECGDDLVLVISRQLYDDVVRTRFHDLDPGRFRATRFSTKGRSYAGYLCAGAARSPVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ9</accession>
    <name>A0A7W7WUQ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan/LPS O-acetylase OafA/YrhL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="42395" checksum="896578A7D3E1F5FF" modified="2021-06-02" version="1">MPKTRRINWDVLRILAVLAVLLQHATHAGPSVHRELGPPAFTFSLEMGASTLVVISAFFACAALAKGEPARFLRNRLARLLPAYVVAATCAYTVLRYVAPPGWSFLEPRDLLVNALMLQNWFPDVRLVDFSYWTLPVQVAGFVAGALLVGRVRGAGLPVLLWTLVVAPLVLRVWTVEPGFVRTFYDGFGAHRAQLFAAGVGIWLWSRDRITTRHLALLLPAVLVAQAVHSADVPSTLALGVMLVAVAACAAGPDWTVWPLTVLRRPVRWLAGISYGVYLVHQEIGYVVMAAVAGYGPWVELAAFLGTAVGLGWLLTRCVERPAHRALTASRPELAGLLLTAGLRAQSHFGSVGAVPFSSAPLWRPVSQPSTAAALPLTVRDSPALPEPNGQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV15</accession>
    <name>A0A7W7WV15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21754" checksum="0449A80F65492471" modified="2021-06-02" version="1">MTHPTTRGRVKVAGLQPAQVLAGLVGVFFLVAGVAGFVRTGFADFDRHEVLLGLTVNPLHNVVHLAFGVLGLLMATGSGLSRLYGWILFVAYGVVLVWGLMLVGVVAVNPVARLGDPLALDVRANWLHLGFTALGLLIAVLPARHRIVVPEETVVAPPRDESIREPHVPDPRVETPDPTVTTRPTRPIDPAVAERHQARHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV72</accession>
    <name>A0A7W7WV72_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="35173" checksum="2BC83F1EE4F27B70" modified="2021-06-02" version="1">MRAVALGGGRGLHVTLTALRRLTDDVTAVVTVADDGGSSGRLRRELGLLPPGDLRKAMVALAAPEAALWSELFQHRFGGTGALAGHAIGNLVLAGLFERLGDPVAVLAEAGRLLGVRGRVLPMCTEPLQIEADVTGLDDDEDVSRRIRGQVAVATTPGRVQRIRLFGPGGPGTVPKGCPEAVDAVLGADVVLLGPGSWFTSVLPHLLVPELHDALVRTAARKVVVLNLVPQPGETAGFSPELHLDVLRGHAPDLRVDAVVADTGAVPVPDRLVRAAAALGATAHLAAVGVDGAPDRHDPVALAAAIDRALHRPPDPPGEPSSRTLHTAVEIRGGEEPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD4</accession>
    <name>A0A7W7WVD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="220"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="446"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="568" mass="60910" checksum="4C8D27498F5D9A1A" modified="2021-06-02" version="1">MSTELLRLVARREPDVFLLRKSGREVAAAVGLDGQDQVRVATALSDLGREVVRLPEPVVLRFGLVSTPGPALVIVVETGQADGPGWDTARRLMDRVEVAVDTVTLVKTLPAGHDEPDAARLTRLRRELATSDGADALDELRAQNQELLETLESLEAKRVELERLNDELERTNQGVLALHKELSDELEQTNQGVVALYAELEEKSTQLREAAEARTRFWSNISHELRSPVNSVVGLARLLGAPGGDPLTDEQRRQVDLINNAGLTLLALVNELLDTAKAESGNLEPRYTPVDLVPTLTQLRDAMRPVVRPGVDLVVDPVPSVPLVTDEVMLVRILRNLLSNAAKFTETGSVRLGVYPDDGAGTLRLVVTDTGIGIPSRELGRIFEEFYQVPGRLQVGAGGTGLGLPYARRLARILGGDLTVTSEPGTGTTATLRLPVSVPDDLAVETVLLVGPDDEVRARLRAALGGVARTVVEVADGRAALEARADRPDLVVSAVDVPLVGGMEILSVLRGDPACRSVPVVLVGRDLDSAVERTASTLGAAVLAADLVAPESLRQAVRVARNVLRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE8</accession>
    <name>A0A7W7WVE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="13828" checksum="8DD3560A573BAD87" modified="2021-06-02" version="1">MSTAHSTATVGSWEERTWDGRNYDEVSGPKRTRGRMTAVYTGDLEGTGENHFLMSYPDDLSCVSVGIEVVTGSLGGVTGTLVLHHDGGYRDGVASGTVKILSGTGGLVGVTGSGTITWRQDSPGTLTLDYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS9</accession>
    <name>A0A7W7WVS9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12459" checksum="64A383E2E1E69CB5" modified="2021-06-02" version="1">MHRELPDFDMPNDEQVHLAAETFRMLADPTRIRVLWALLQGESSVACLAELAQATPTSVSQHLAKLRLAGLVQGRREGTFVYYSAATHHVKDLLAQALYHADHLDQDARIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW3</accession>
    <name>A0A7W7WVW3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="8">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28022" checksum="B0A015CAF1372935" modified="2021-06-02" version="1">MNTLRVLRLSAITGFADYASVYTVRSWLAGWLFRVLCQVAFFTLVSRLVGPAVHREYLLVGNAVLIAALESCMVVASTTWERRAGTLPLLVASGARPAVVFCGRSVHWVLSGTLTSSVSLFAVGLVFEPDLIRIRSLAVLPLVLLVSITTYCFGLVLAAVVLRFMELRNVVGNLAYLGLMAICGVQVPVDYWPTVVRVVANVLPLTHGLAAVRLVLAGGEAGAVLLQAGTEALVGAAWLAVALGVFGRLVDGGRRNGSIEFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW82</accession>
    <name>A0A7W7WW82_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl transferase domain-containing protein/acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_003454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00694"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1658"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="1692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2026" mass="212306" checksum="F88F754CA949E0DF" modified="2021-06-02" version="1">MANDEKLREYLKRALAESERARQRVRDLESSRHEPIAITAASCRLPGGVRSPEQLWELVANGVDAITDFPADRGWDLDGVYDPDPDAVGTSTTRQGGFVDGVTDFDAEFFGISPREALATDPQHRLLLETAWEVLERAGIDPATLRGTRTAVFAGIAGEDYTPRAATPAEVEGYLGTNTLRSVASGRIAYTFGFEGPAVTVDTACSSSLVALHLAVQSLRSGESDLALVGAASVMTTPFGFVEFSRQRGLSADGRCKAFSADADGTGWAEGVGWLLVERLSDAERAGREVLAVVRGTAINQDGASNGLTAPNGAAQQRVIKAALAAARLTPAEIDVVEAHGTGTALGDPIEARAIIAAYGRDRAEDRPLWLGSLKSNIGHTQAAAGVSGLVKLIGAVKHGVLPKTLHVAEPTPHVDWSAGTVRLLTESRPWPETGHPRRAGISAFGVSGTNAHVIVEQAPARPTAEPGASPVDEAGAGGTTGSAAGSSLPGGAERPSDSVPVPVPVVLSARSATGLAAQADSLLRHVERHPDVRLVDLAFSAATTRAALPGRAVVVAADRDTLVTGLEALARGEQSADLVTGTSGGGLAVLFTGQGAQRFGMGRELYAAYPVFAAALDAVVSEVDKQGDGSRSLRDVLFAEADTGALDDTGHTQPALFALEVALYRLFESWGVRPDFVTGHSVGEIAAAHVAGVLSLPDAAALVAARARLMAALPRGGAMIAVEAREDEVLPLLAGRGHEVGLAAVNGPTSVVLSGTADAVEEIAARFADRRTRRLTVSHAFHSPLIEPMLDPFRAVAEGLAYHPPTIPVVSNLTGAVADPAVIATADYWVRHVRGAVRFADGVAHLNDAGVRTFLELGPDGVLTALVRTTLADERVQARPALRRDRPEAATALAALGLAHVQGTRVDWSAVFADHDPRRVTLPTYAFRRDRYWVGDIVRPAGTGTVGHPLLDDVTHLADGGVVFSGTLSTSSHPWLVDHAVRGTVILPGTALLDLAVHAGDEVGTGVVDELVVAAPLVVPNRGAVRVQVSVAEPDETGRRAFGVHSRVGGAEWTTHATGTLTDDTPTDDTLTDDTPQAPAGFAWPPAAEPVDTAGLYAELADAGLYYGPVFQGVRAAWRADDVFYAELDLPDTAGVDGFGLHPALFDAALHVPAHHDLATNPPGTNRLPFAYRGVRLHATGARSLRVRLTLTAADELALHAVDPSGAPVVSVDALRSRLITEDRLAAARSTDQDALFELTWTDAGEAGPVPDHDVLEVTHAGNAELPREIRATLHEVADRVRAYFADSDRVLAVVTRTAVAALPGDLPDGVTAPLTGLLRAAQAERPDRIVLVDLGADDVFDPKVLGLGEPQVAVRGDRVLVPRLTRVTAPGTGGRSWNPDGTALITGGFGVLGAIAARHVVRAHGIRRLVLIGRRGADTPGADTLLAELAEAGVEVTAVAGDVGDRDFLADVLAAIPAEHPLTAVVHTAGVVADGTLDTFTSDQVDTVFAPKVDAAWHLHRLTRDLDLAAFVLYSSVAAILGGPGQGVYAAANTFLDALAVHRASVGLAATSLSWGQWATPSGITGHLTRTDLARSARAGLRLVDDEQGTALLDAALSLDRPTLVPAPLDLAAVRTRPVVPAVLRGLVRPARRVASADAPGLRARLAGLDAESRHEVLVDLVRTEAAAVLGTTTDALEPDRPFVDLGLDSLTSVELRNRLDTATGLRLPATATFDHPDAGALAAHLDAALGDLADTTPAPTPGTGQGPLSTLYRALAGGGRYPAAAEIIGVASHLRTSFTAAQTPDHVLPPIELATGPGRVKLVLFPAVSAISGPHEYARFGHSMAGERDVLVVPSPGYRDTDSLPDSEDTYVRMHAETVKAWVGDEPFVIVGRSMGGCIANAVAAALEADGVVPLGQVLIDSYLIESPKLPGFRDWWLKAMLDGMLDRIERYRMVWSDTSLTAMGGYGRILADWAPAPIGGRTLLLRAGEPLRGTITDGPHDWRPTWPFPHEVADVPGDHFTVLEDHAETTVRAVRDWLATFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA8</accession>
    <name>A0A7W7WWA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10703" checksum="C9EF0BDC3F6B6401" modified="2021-06-02" version="1">MADILPFPRKRTPGPDPLWREVLGRTLRAAREEQGARLVDVAERAGISPQYLSEIERGRKEPSSEMIAAVTGALDLDLAGLLTDVAGNVRNESPVLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWC5</accession>
    <name>A0A7W7WWC5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21336" checksum="D9503CB22D2DF66D" modified="2021-06-02" version="1">MDLQNDFCAPEVVAARHGAVPEDLGGVVARAVRSVDVARADGVEVVFVRFLGDFVHQGASWRARDAVLDKRPQCLEGTWGAEFHAVTPAGDERVFTKRACFDAFLADGFEAHLHARGVDHLVLAGLYADVCVDSTARTAFQKGLHVTVLSDCTTSLHLPCPDVLRFMNRVYGARTLPLDVWATERNQAWTGSTGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX2</accession>
    <name>A0A7W7WWX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="16883" checksum="35FB41E052AE3AC9" modified="2021-06-02" version="1">MCEYCGCLALTAIADLTREHDQVVTLISHIRAAHTGGDLAAMATAARQIAAVLGPHTAVEEQGLFPPLAAEFPDHIADLTAQHRHIESALGEATDGVPTDPTWPARLLDALHLLREHILAEQDGVFPAALSSLDTADWDAIEVIRARVGTTAAATTPASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA8</accession>
    <name>A0A7W7WXA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="124"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="34939" checksum="D357B0E5C1F77998" modified="2021-06-02" version="1">MKLVEQLRGRFGVEFVLRVLGVASSTYHGWVARQVNPSRREHEDEAITAEIVDIHTASGGTYGSPRVHRVLRRRCIRVSRKRVERLMRQAGLQGAFLRKQWRAPSTRQDPRAAPAPDRVNRDFTAPAPDRLWVADATRIRTGEGVFWLAAVRDAFSNRIVGWKTSDRCDTDLVLGALEYAIWSRDVRDGQLIHHGDRGSTYTAFRFAERLADNGILPSMGSVGDSYDNALMENFFSTLKIELVYRRSWRTRDEAENELFRYIDGFYNTERIQKDLGWLSPDEYEAAWHATQAEPTTIPASPTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD0</accession>
    <name>A0A7W7WXD0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="36776" checksum="D5EB9D89D5430D75" modified="2021-06-02" version="1">MARTRRYRDGVLEAEDFPAEEIPRHLAEDGVTVWLDLCEPTRDRIAAVADELGLHELAVEDALFEHERPKFHRYDTHCLLNAYAVRLDRRSGRLATAELTAFVTHNALVTVRTRKFDMDAVVRAWDQSSHLAASGVPFLLHGLVDHIVDTHFEAVQALDDHVEQLEDLVFAEHSTNEEMQRRSLAMRRSLVTLRRVVVPMREVITPLLRRDHDIVDDVMQPYFQDVLDHVLRASEWTESLRDLVATIRETQLSIQGNHLNLIMKKVTGWAAVIAVPTAVTGYYGQNVPFPGNGEPWGYWVSTGVVASLSIGLYVLFRRRDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL8</accession>
    <name>A0A7W7WXL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15627" checksum="2B4A666541BF7143" modified="2021-06-02" version="1">MDLEDTGHVARIRFLIRDRDGKYPALIDEILGGAGIATILTGVRMPRMNAIMERWVKSLRGELLDRTLIWNEAHLRHALREYERHYNEHRTHRSLAAAAPLRARPQSLGPDRIERLAVLRRDRLGGVLHEYRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR1</accession>
    <name>A0A7W7WXR1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="28336" checksum="0D3FDBA23D0C96BF" modified="2021-06-02" version="1">MGDTLKVPGARLYHEVSGTGPVLLFIGGGTSDTSNYDGVGPHFADRYTVVSYDRRGNSRSTLDGPAGPQRIEEHADDAIRLIEHLGTGPADVFGSSSGALIALDVAARRPDLVRRVVPHEAPAFTLTPDEDAHLAILHRAAAEFERAGAAAGMAVFGNGTGVPDEFADAGPEALEALRRIEGNAPFFFRHEMLQFVAYRPDLPALGRHRDLLVPAVGEESVDTPPVQAMRVLAKEIGTEVTAFPGGHVGYLQRPVEFAARLAEVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXS4</accession>
    <name>A0A7W7WXS4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="41"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="38313" checksum="858AF376DF3F4890" modified="2021-06-02" version="1">MRSIRPQDARIAGVEPLITPADLRAEIPASAAAITTARQAREDIRQVLSGEDDRLVVITGPCSAHDPASALDYAERLAALAADVADHAVVVMRVYVEKPRTRLGWKGLLTDPHLDGSDDVNSGLRLTRGLMTQIAGSGLPVACEFLDPSVPGYLADVVSWGCVGARTVQSQTHRQFASGLPMPIGFKNATSGDVLDAVDAIVAASRPHTFPSVTDDGRVGLVTTTGNPDGHVVLRGGSAGPNYGPIDVAKSLRLLGQAGLEQRLVIDASHGNSNKDHRRQPLVVGDLAGRIGRGEEGVAGVMLESFLVEGNQKLVLGRSEQLAYGQSVTDACVDWSGTVRLVERLAEAVATRRAAFHPQAALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXT5</accession>
    <name>A0A7W7WXT5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021499">
        <property type="entry name" value="DUF3153"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11353">
        <property type="entry name" value="DUF3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030540423" evidence="2">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23161" checksum="5609B91306A3181B" modified="2021-06-02" version="1">MSRSPARLVPVFLLLMLALSGCVRLHAAMAVSEDDKVSGEIVAATPPTQDSDPGPQLKVPSELAERVTTKAYKVDGYAGTQLLFTGLSFEEVRTLASVTSPSSSRYQLNFRRSGDLVTLSGSVDLSTVPVDRADIQVKISFPGEVVDTNGREEEDATIAWDPRPGQASMLTATVRYEGENAPSYVGWTLLVAGLVGVAVLIVLALAVVSHRRSLVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXU7</accession>
    <name>A0A7W7WXU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29198" checksum="5AD7F6B0FCC81C81" modified="2021-06-02" version="1">MNSTNGLRRVAATRYVTPFREGGSLPGLVEADDLGMYVLKFRGAGQGVKALIAEIVVGELARRLDFRVPEIVLVDLDPELARAEPDQEVQELLRASGGVNLGLDYLPGSFDYNPVVRDPSVEDATRLLWLDALTLNVDRSWRNPNTLLWHRDLWLIDHGASLYFHHSWNPERFPAAKYRFDAADHLMLPFAGPLAGVDAELAARVTPELVREVLALVPDEWLAQDEVFAEPRAAYERFFAARLADRTWVDELEAARVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY24</accession>
    <name>A0A7W7WY24_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Uncharacterized N-acetyltransferase F4559_005329</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acetyltransferase Eis family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01812">
        <property type="entry name" value="Eis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022902">
        <property type="entry name" value="NAcTrfase_Eis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="4">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="44963" checksum="4DB58D7FF808493B" modified="2021-06-02" version="1">MSFTVRTLTEDELLPHARLTVAAFMLDTPEERIGRWTGLHEPDRTHGVFEDGALLGAAGVQTRHLTLPGTGPRPFAAVTTVVVDPGHRRRGVLRRLMTEQLTALHDGGEPVAALWASEAAIYGRFGYAMASEVVRLEIPQRAAFRPRVDIGTDRVRLVARDEALPLVKDLYERVRPTRTGWISRNDVQWAYFLSDDEWDRHGQSAYRYALHPDGYVVYRLKADWQDRGPRGELHVREFVAATPEATAALYRHVLDADLIGEIKYSVAATDDPIVHLLADSRLIRRRRSDSLWVRIVDVDRALASRTYSSDVDLVLEVADDLCPWNTDRWRLTVRDGVAEVTRTPDEADVVLDVRALGSAFLGGQRLTSLTGAQLVAEVTPGSLRALSSAFLGDHDPHCHEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY48</accession>
    <name>A0A7W7WY48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="821"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="883" mass="93936" checksum="5913C518AF66E835" modified="2021-06-02" version="1">MGVVLHGRAAESAVLGGVLDSARDGNSGVLVVRGEAGIGKSALLGAVDAEGFRVLRGTAIESESVVPYAGLSLLLRCVSDGIDVLPPRQAATLRIVLGDGECGDTDPYHVGVALLALLAELAERQPVLCLVDDAHWLDQGSAFALLFAARRLRAESVAVVFAARDLHAPPFPAPGVPELRLTALSDDDAFALLAEHAADLPRHVRERIAREAAGNPLALLELPAAQREGHLTAGPAHPPATLPAHSRVRRMFADRIAALPERTRTLLLVAAADDTGDPGVVFPAAERLGASVADLEPAEQRQLLRSDDGRIAFRHPLVRTAAYRGASLVGRIDAHRALAGVVADETRRTWHLAAATTSPDEDVARALERLAETARKRGGSSAVLAAYHRAAELTPDPKTRGRRLTLAAAAAVEAGHFDRASALADSAADLLRDPLEYAKVARVWATLAGERGESAEAATILGKAAHCAATGDPDLASELLFTATQNAWTARDFTAVRGFAEQASGLPGAHRVKALARAAIGLDECDVPDTLAAMRELVADPREDVTRAWWHLVLGDDRAAYDHAATVERRARASGALGPLPRALAYLARARLNLGQPREARETAEEGLRIAADIGQGFSVGFLSCVLAEQAALAGDERRVAELVGALGGTGGPPTAVRAMCASALLDLGLGRPEAVLERLADVGAARLYAIGSLPDLVEAAVRVGEVGQAKRAADWYAEWADGTGHDWALAVADRCRALVTDEERYYLAARDRHRSPARPFERARTELLYGEWLRRERRRVESRVPLRSAAETFERLGATPWAERARQELRATGESRPAPGPDPVGALTPQELQVVRLAAAGLSNRDIADRLFLSPRTVGYHLYKAYPKLGVASRGELARVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE3</accession>
    <name>A0A7W7WYE3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Broad specificity phosphatase PhoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22262" checksum="48AFDF0A83A545F2" modified="2021-06-02" version="1">MTLDRLVLWRHGETDYNATGRMQGHYDSALTETGWNQARFAVPVLSGFAPELVVCSDLRRARDTATVFTQATSVELRVDERLRETHFGKWQGLTAAEIAAEWPGALDAWRVDASLAPPDGETRIEVAERAAAVVADVDAECSGTVLLAAHGGLISALTGRLLDLPTDRWSLLGGIGNCHWTVFTRRPGGDGRWRLSSYNAGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH4</accession>
    <name>A0A7W7WYH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="33279" checksum="31FBC28FE43366A6" modified="2021-06-02" version="1">MGRYVLRRLLQMIPVFLGTTFLIYVMVWAVPGDPFEGKCGERDCPPSYVAAMREQFNLDDNVFVQYGKYLANLLQGDFGKTSSGLEVADRIAATFPVTLKLAVVALLIEAVIGITAGVVSGLRGRGFLDSLVLVSTLFLISIPVFVTGYVVQLVFGIQLGWITPTVSKPTFVNLIVPGFVLASLSMAYVARLSRASIAENKRADYVRTALAKGMRPRRVVGVHLLRNSLIPVITFLGTDLGAFLGGAIVTEGIFNVPGVGGLVFRSILTKDGAMVTGVVTVLVLVYLLMTLLVDLLYAVLDPRIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK7</accession>
    <name>A0A7W7WYK7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="6757" checksum="020715FA5184B685" modified="2021-06-02" version="1">MRIEVDPDRCAGSGMCALTDPDVFDQSDEDGTVVLLDPSPAAEHHRGARDAAHLCPAGAIRVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY9</accession>
    <name>A0A7W7WYY9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ORF">F4559_006106</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="37680" checksum="B9F6DF5164553786" modified="2021-06-02" version="1">MTAVDLGVPVVRAATDLSGRPDTPALVDRFGRHATDLRVSLTDRCNLRCTYCMPAEGLDWLPKPDLLTDDELVRLIRIAVTDLGVTDVRFTGGEPLLRPRLEDVIAAVAALTPRPRLSLTTNGVTLARRAAGLVAAGLDRVNVSLDTLDPARFRDLTRRDRLDDVLAGLAAAHAAGLAPVKVNSVLMRGVNEDEAVPLLRFCLDNGYHLRFIEQMPLDPQHGWDRGEMVTAGEILAALGTAFSLTAHPQERGAAPAERWLVDGGPATVGVIASVTRPFCASCDRTRLTADGQVRNCLFGRTETDLRAALRGGASDAELAGLWRGDAWAKAAGHGIDDPGFHQPDRPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ28</accession>
    <name>A0A7W7WZ28_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar basal-body rod protein FlgC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="2">
        <location>
            <begin position="80"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13782" checksum="0F951FF9C6D56B7A" modified="2021-06-02" version="1">MFDSIDIATTGASTYRKWLDAVSDNIANINDVAPTSGAAFQERYVVATSLPRGGVTVSGIELGSAEGRMVQNPDHPLADEDGYVRIPDIDLSEQMGYLIMAQRGYQANLAVVDRATSAYEAALQLGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZF0</accession>
    <name>A0A7W7WZF0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">F4559_006888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8683" checksum="3450D7285B022AB5" modified="2021-06-02" version="1">MARVVVDVMPKPEILDPQGQAVANALPRLGFDGVETVRQGKHFELEVADDVDDATLAKIAETFLANPVIEDWVVRRVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZJ5</accession>
    <name>A0A7W7WZJ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="31465" checksum="72B55D30CAA8F647" modified="2021-06-02" version="1">MDEQLRVGLIGAGPWAERVHAPAIAGHPGSRLVSVWARRPEAAAGLAGAHGAATASSPEELISQVDAVAFAVPPEVQAPLAIQAAEAGRHVVLEKPIAGSLDEARRLADAVDRAGVASLVVLTKRYTPDTREQLERVHAEGGWVGGSVRWLTGALLSGPYSHSPWRHERGALDDLGPHVFDLLDAALGPVVEVVAADRSAHDVWQVVLRHEGGATSTAMLTMSLAVSPPVLEVEVYGTAGQRTLTTPATTPIEAYTNLLDEFAALIDSGKTSHPLDVRRGLHLQSIIAKIRESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZJ6</accession>
    <name>A0A7W7WZJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase E1 component beta subunit</fullName>
            <ecNumber evidence="2">1.2.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="36848" checksum="93DEBD003A77C873" modified="2021-06-02" version="1">MAAPTVDRPTDAGPAAVRTLTLAKALNTGLRTAMENNPKVIVMGEDVGKLGGVFRITDGLQKDFGEQRVLDTPLAESGIIGTAVGLAIRGYRPVCEIQFDGFIFPGFDQIVSQVAKLHYRTSGRVKLPLVIRVPFGGGIGAVEHHSESPESYFAHTAGLKVVSCSNPSDAYWMIQQAIDCDDPVLFFEPKRRYYEKGEVDTASTTTPLFSSRVLREGTDATLVAYGPMVRTALEAASAAAEEGHSLSVIDLRSLSPLDLGPVYESVRRTGRLVVVTEAPSESSISGEIATRVQQECFYSLQAPVLRVTGFDTPYPPSKLEEEYLPDLDRVLHAVDRSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZK0</accession>
    <name>A0A7W7WZK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="273" mass="29763" checksum="158DEE7A4C748B14" modified="2021-06-02" version="1">MTVNLGEYGAWGLADVWPGREEEAAELESLGYGALWLGGPSARTLDTVRELIEATSTLTVATGILNVWATPVEQVNERYRELAWTDRFLVGVGIGHPETNGEVYHSPYQKLVDYLDRLDVPRDRLALAALGPRVLRLAAARTSVAHPYLTTPEHTAQARETIGAGVLLAPEQHVVLETDPDAAREIGRGELEFYLGLENYRANWLRGGFTADDFADGGSDRLVDALIAWGTVEQVVARVRAHRDAGADHVCLQVVGQDGVPLPAYRELAAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZN6</accession>
    <name>A0A7W7WZN6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymethylenebutenolidase</fullName>
            <ecNumber evidence="2">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="23642" checksum="A24CDBE477D75BE8" modified="2021-06-02" version="1">MTPTRTETLSLTDGRELRLTVAEPENAVRGGLVVLHEARGVTDEVRRLVSGLAGEGWLAVAPHLYPGDGDEVAGEEVGARVGALSGEAVLNDTDVAFLWLEQRGVSRDQLGVMGFDLGGSVAMVVAASRSIGAAVTVGGGGIVQPLSAGLPALLEIAPELACPWLGLYGDEVPVVEVEKLRDAAETASVVTDVVRFPDTGHRFDASPAAGAEAWQRALNWFDAHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXM8</accession>
    <name>A0A7W7SXM8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="9" type="ORF">F4559_000127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="107"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="26586" checksum="E8BF94CB258C6C74" modified="2021-06-02" version="1">MAAQRGEGDEVVTSPATTTPEPAADVRERARAIPEAAVARLAVYLRVLSGLGDQGVTTISSEELAGAAGVNSAKLRKDLSYIGSYGTRGVGYDVEVLVGHIERILGLTRKHSVAVVGIGNLGHALANYGGFGSRGFPVAALFDIDDDLTGVPVGGIPVHHIDDIVTVCTEREISIGVIATPPQAAQAVCDRLVSAGVQCILNFAPVVLQVPDNVEVRKVDLAVEMQILSFHVARRADEAAGDVVNGVGVDGVVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY29</accession>
    <name>A0A7W7SY29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uroporphyrinogen III methyltransferase/synthase</fullName>
            <ecNumber evidence="7">2.1.1.107</ecNumber>
            <ecNumber evidence="7">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="7"/>
    <dbReference type="EC" id="4.2.1.75" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="6">
        <location>
            <begin position="252"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="510" mass="53253" checksum="F82AD31858FC469D" modified="2021-06-02" version="1">MNRARKTPGRVAFVGSGPGDTGLLTVRARDLLAKADLVVTDPDVPSDVVALVPSGVEVRPAVGDPADVAKDLVAEAKNGSAVVRLVAGDPLTLDSVVKEANAVSKTTIAFDVVPGVPAGTAVPAYAGVALGAVHTEADVRGVEDWAGLAAAPGTLVLHATGSHLAEAASSLVENGLAPQTPVAVTVDGTGFGQRTVDTTLASLAADAGELAGPLVVTVGSAVANRTRLSWWESRALYGWRVLVPRTKEQAGAMSDRLHAHGAIPVEVPTISVEPPRSPAQMERSVKGLVDGRYQWVVFTSTNAVRAVWEKFREFGLDARAFSGVKIACVGEATAAKVRGFGIIPELVPSGEQSSEGLLADFPPYDDILDPVDRVLLPRADIATETLAAGLRERGWEIDDVTAYRTVRAAPPPADTREMIKSGGFDAVCFTSSSTVRNLVGIAGKPHARTLVACIGPQTAETAREFGLRVDVQPEDANVPALVDALAQHAARLRAEGALPPPRKTKRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ0</accession>
    <name>A0A7W7SYZ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030802430" evidence="1">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10367" checksum="1E0A2D90BA362F6A" modified="2021-06-02" version="1">MKSIGTRRTIVGLALALGTVTAAAIPAAAAPAQVLSGYQCVSAETLTLWNAPSGGNAVGTWVRGTRFSNEGIDGSRFATRTLNTGVRVWVDANPAWSYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ1</accession>
    <name>A0A7W7SYZ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="10231" checksum="64911DBD4F54F841" modified="2021-06-02" version="1">MAGTSERIEARRRARETTARRVRELREREERLGRMAAAFFEQDALRERHELASARSVVGLLDAGEPVDAVAELLGVEVSRVRWLARRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ19</accession>
    <name>A0A7W7SZ19_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FxLD family lantipeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027575">
        <property type="entry name" value="LD_lanti_pre"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04363">
        <property type="entry name" value="LD_lanti_pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5469" checksum="46652AED177D4FD7" modified="2021-06-02" version="1">MTTAAIDAPATDVFDLDVRVETRRVETEAAACQTDDGCGHTCELSACHSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZR9</accession>
    <name>A0A7W7SZR9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="496" mass="52678" checksum="04FA01E5FB1424C0" modified="2021-06-02" version="1">MRVLDLGIIALFLIGMPLLGALIGGRQRSATDYFVSERRISWWVVCVSVVSAETSTLTVLSVPTVAYGGTMTFLSLAVGYLLGRIVVSFVLLPRYVAGDLITAYGFLGRRFGPDVQATASVTFLITRLLADGLRLFATAIPVKVVLAAYGVDVSYWVIVAVLGAAMVVYSFLGGVRAVVWVDAIQLLWYVLGAAVVIVVLSGLLPDGWFTAASDAGKFRVLDFAANPLTSPYAVVTALVGGAVLSMASHGADQLVVQRLMATRDVRSARRALIGSGVVVFLQFALFLLIGVMLWAFYKGAPPVAGLGLHNNDELFAHFVVREMPTGLSGFVMAGILAAALSSSLGAMASSTVADVYRRFARRETTEQDVLRQGRIWTVVWAVLLVVCAGLFSSLTRRGDPIVEQGLSISGFTYGALLGSFLLGLLVRRARRADALVAFVVTVAVMTFVILGVDFGGKALAYPWYTSLGVVVTLVVGGLLSLRGTGDSRPSGRHDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS8</accession>
    <name>A0A7W7SZS8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">F4559_001298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015104447.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8562" checksum="03A95116D9AEFD38" modified="2021-06-02" version="1">MSLLADALEHLVRGIVDHPDDVRVNLVTTRRGRTLEVHVHPDDLGKVIGRSGRTATALRTVMAGIGGRGVRVDVVDTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZV8</accession>
    <name>A0A7W7SZV8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16124" checksum="1027206982DB76BD" modified="2021-06-02" version="1">MTAVLVLVVLSANGLAAGVLLWSAVCGVPLLRTLDPGRYIEVERLWGNRFEPFQPICVVLTVLADVLLAVTGPVSRPLFAVAAVAAAGVIAISTTRNVPLKRWVMSLDPAAPPEDFEEHDPRPEWARWNLTRTVLASVAFVANALAVAGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY4</accession>
    <name>A0A7W7SZY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane-anchored protein YjiN (DUF445 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="46085" checksum="C2FF287C9F6D4CCE" modified="2021-06-02" version="1">MEQLTAADQLKRRDLRRMKLVATGFFLAASAIFLGALLFEEGGPAWVGYVRAAAEAGMVGALADWFAVTALFRRPLGLPIPHTAIIPTRKKAFGDALGSFVGTNFLSEAVVRDKLRRVGIARRVGEWLSDEAHAERVTAELSNVIKGAVTVLRDDDVQAVVEHAVVRRLTEQQWGPPLGRLLGQVLTDGAHHKLVDLMCDRAYDWVRDNHDKVMNVVSDRAPTWSPRFVDSMLGDKVYAELLNFAWAVKTDVNHPMRQALDQFLVEFSGDLQTDPATMARADQVKQQVVDHPAVRQVIGSAWGTAKGMLLTAAEDPSSELRKRVRDGLLSFGARLGSDEAMRTKVDGWLEGAAAHVVTNYRDEITTLITDTVERWDAEETSRKIELQVGRDLQFIRINGTVVGALAGLVIYTLGQLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T026</accession>
    <name>A0A7W7T026_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminopeptidase S</fullName>
            <ecNumber evidence="5">3.4.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.24" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030510952" evidence="3">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="4">
        <location>
            <begin position="98"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="32380" checksum="B74C23E756ABA450" modified="2021-06-02" version="1">MRLRKIVTTLGVVAVITATGTATAAPATTLAAAPDISVAAVQADLAQLQSIASSNGGNRAHGRPGYQASVNWVKAKLDAAGFTTRVQSFTHSGATGYNLIADWPGGDENNTVMVGGHLDSVNAGPGINDNGTGSASILEVALAVKATGFKPTKHLRFGWWGAEELGLIGSTYYVNSLPAAEKSKIKTYLNFDMTGSPNPAYFVYSASGQPSGSARLQQVLQAYYTSINVATELTTVGGRSDHAAFARAGIPVGGTFSGAEGTKTSAQAQKWGGTAGRAYDPCYHRSCDTTSNLNATALDRNADAIASAVWTLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T090</accession>
    <name>A0A7W7T090_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="7" type="ORF">F4559_000254</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11406" checksum="D7E25A440DD60F1A" modified="2021-06-02" version="1">MKVKKGDTVVVIAGKDKGARGKVIQAYPTQNRVLVEGVNRIKKHTRITQTQRGAQSGGIVTQEAPIHVSNVMVVDSDGKPSRVGYRTNDEGKRVRISRRNGKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T093</accession>
    <name>A0A7W7T093_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008692">
        <property type="term" value="F:3-hydroxybutyryl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="472"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="684" mass="72020" checksum="8ED829D736503C72" modified="2021-06-02" version="1">MTIHYERDDTGVVTLTMDLTGSVNVMNAEYRAAMGAAVSRLEAERDKVTGVLLTSAKKTFFAGGDLAVLVGVERDDLGDTMAFVADVKGQLRRLERLGRPVVAVIEGSALGGGLEIALACHHRVVLDDDRIRLGLPEVTLGLLPGGGGVTRLVRMLGPRAALPLLTEGTRLRPEAAAEAGIVDAVASTPAELRDRARAWIAANPDPVQPWDRRGFTVPGTAGSEYAGLLASAPAMLRKKTHGVYPAPEKILAAAIEGTLVDVDTALEVESRYFVELLTGQVAKNMIGTYWFALNAITAGAARPSGVPPTSVTKVGVVGAGLMGSGIAAVCAAAGLEVVLKDVTREAAERGARGLPGITPTDSDADLAGCDPVIEAVYEDRPLKRRVLGDVAAVVSRDAVIASNTSTLPITGLADAVADPSRVIGLHFFSPVPRMRLVEIVVGARTSDDTLARAFDFVRHIGKTPIVVNDARGFYTSRVFGAYVTEGVALVAEGVGPALVENVARRSGMAVGPLAVSDEVALTLPLAIREQTLAEDPDASGVFADHPALDVLADLVGQGRTGRSGGGGFYEYPADGPKRLWPGLSRYRREVDVPERDVEDRLLFAQVLETVRCLDEGVLRSVGEADVGSVLGLGFAPWSGGTLQFVNAYGPAAFVARADELADRYAERFRAPESLRELARVGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A0</accession>
    <name>A0A7W7T0A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="166"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="27242" checksum="ECDBCD93FA17229F" modified="2021-06-02" version="1">MLDRRIAQTFVELADTLVLGFDAIDFLHTLTERCAELLEVDAVGILLADQRGALNLVAASTEQARMLELFQLQDEEGPCLECFRTGQPVACDDLAQEPQRWPRFTLAAREQGFSAVHAVPMRLREQIVGALNLFRTSPGVIPEDAVELAQSFANVATISILQVRALRHSEMVTEQLQNALNSRVVIEQAKGILTERLQIAVADAFSLMRNYARTHNQLLSDVAKQVISRSPEVAELTGIDNLGSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D1</accession>
    <name>A0A7W7T0D1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="25345" checksum="7A00C1AEC92DD857" modified="2021-06-02" version="1">MDIGGSTALVTGANRGLGRVLAAELLARGAKTVYAAAREPDTVTVPGVVPVRLDVTDPGQVAAAAERCGDVTLLVNNAGVLTNSPLLGVSGTEPAAREMAVNYFGMLAMCQAFAAPLGRNGGGAIVNILSVASFYTNPATGSYSASKAAAWALTNGVRVELRRQGTLVVGVHCGYIDTDMAAGVTAAKASPEHIAALTLDAVRDGYEEVLADEKARAIKASIPRHLEELYPEVQRAWDSRVTPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D8</accession>
    <name>A0A7W7T0D8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25174" checksum="BE83DE7F83335E0A" modified="2021-06-02" version="1">MLLEIKDIHVHYGKIAAIKGISLEVGEGEIVSLIGANGAGKTTTLKTISGLRPLTSGSILFDGADISRMPGHKRVVAGIGQSPEGRGVFPGMTVQENLLMGAYTRKDDLTADLDEVYELFPRLAERKTQFGGTMSGGEQQMIAIGRALMTKPRVLLLDEPSMGLAPKLIAQIFEIIKEINKRGTTVLLVEQNARQALKLSDRAYVLETGRVVKSAPGLDLLDDPQVRAAYLGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K3</accession>
    <name>A0A7W7T0K3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="4">AGPR</shortName>
            <ecNumber evidence="4">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="4">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argC</name>
        <name evidence="7" type="ORF">F4559_001737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="6">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="34504" checksum="A38147EA129184D0" modified="2021-06-02" version="1">MTVRIAVAGASGYAGGELLRLLLAHPDVEIGALTAGGNAGTPLIAHQPHLLPLADRVLAETTPENLAGHDVVFLALPHGKSAEIAARLGTDTVVIDCGADHRLTDARAWERWYGGEHAGSWPYGLPELPGHRAALHGTKRVAVPGCYPTVASLALAPAVDHIGPEVTVVAVSGTSGAGKSLKPNLLGSEVMGSLSAYGVGGTHRHTPEMIQNLSKAAGRDVAVSFTPVLAPLPRGILATCSATLTGTVDIREVYAKAYADEPFVHLLPEGHWPTTGAVLGSNAVQLQVTVDPDLNRLVVVAAIDNLAKGTAGAAVQCMNLALGLPETTGLSTVGVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U9</accession>
    <name>A0A7W7T0U9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6381" checksum="835A8B152509858C" modified="2021-06-02" version="1">MSTAPRWRKSRHSGANTNCVEIDSTLTAIRDTKNPAAVLRFSDATMSRFLTRVARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U8</accession>
    <name>A0A7W7T1U8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin Q/BCP</fullName>
            <ecNumber evidence="5">1.11.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16059" checksum="E944F2EBE498DFB3" modified="2021-06-02" version="1">MRQGERAPDFVLPDQDGTPRDLAGLLAAGPVVLFFYPAALTGGCTAESCHFRDLGAEFAEVGAQRVGISPDAVDRQKQFAEVNGFDYPLLSDVDGTVAAAFGVRRRFGPLPVKRHTFVIGTDHTVLAVVKSEFSMTTHADKALEVLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W4</accession>
    <name>A0A7W7T1W4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="122"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="34634" checksum="07010A707E19B633" modified="2021-06-02" version="1">MPLHRPSDDGPASFHDMLSTAGYRAVATALELGLFAALTEGPLDADDLAARLGTDPRGTGLLADVLVTLGHLEPGYANSPSTTRWLTGPYAEVDRFWSTVLFSSWTDLTESVRTGRPALDFYRWLVENPETLHRFQAMLSTHADAIAPEVTTLITPGVTLLDVGGGHAKYAIRFCAGNPDLTATVVDLPDAVEVGRAAVAAAGLTDRIGFAAGDYDEVDLGGGYDTVLLFNVVHGRAPDANVTLLARVAKALRPGGRVVLLEHDHHVPDAGSDAFARVFSLNLFHGQGGQVYPASEITSWLTKAGFTEPTVHPLSTSPGQSLLVATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W7</accession>
    <name>A0A7W7T1W7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8526" checksum="92384C7C359D23EF" modified="2021-06-02" version="1">MDSPKDVTVQEFLDDLCDALAHIDVVQPADLREPLSLWLRATEERALRDGWTHLLGRSVTAEWNATRAILRAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z0</accession>
    <name>A0A7W7T1Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="35" mass="3941" checksum="44B8A3ED1D4CDACB" modified="2021-06-02" version="1">MDGIFVNVEEERQLPHNSATHSNALVENPFEGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T237</accession>
    <name>A0A7W7T237_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17687" checksum="79100CD07FD8FAFC" modified="2021-06-02" version="1">MSMTATTSAAPSPRSGPRDRVHQQALGEAIAGYRLLGWKVSVTEQGVFLPLGPATTALAMPARIGSRVLADLKSRMLAGPVTVIPGPREHWIFLAELVALLPTHLKAPAEVQFVRSPQRIALPPTMTRYGSLRWANPPSHSRHWFPPFTAVLALARSAVSQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N1</accession>
    <name>A0A7W7T2N1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Proline iminopeptidase</fullName>
            <shortName evidence="4">PIP</shortName>
            <ecNumber evidence="4 6">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 6">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="44"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="35291" checksum="F6BFEEB6D8A5FDDC" modified="2021-06-02" version="1">MTNTSDDGRHPSSEPYESGMLEVGDGHSLYWEVSGNPDGKPAVALHGGPGSGSTPRMRGLFDPDRYRVVLFDQRNAGRSTPSAADPVVDLSANTTGHLVDDIEALRVHLGIDRWLVLGGSWGVTLALAYAQAHPARVTEMVLAAVTNGDRRDTDWITRDMGRVFPREWERFRAGVPAAERDGDLSAAYSRLLHDPDPEVRATAARRWCEWEDAHMSLAPDATPSLSVADPAFQLVFARIVTHYWSNGCFLDEGQLQRGIDRLHGTPAVLIHGRYDVSGPLGTAWALHRAWPGSELVVLDDTGHGGGGMRAAMIAALDRFGRGQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Q2</accession>
    <name>A0A7W7T2Q2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17327" checksum="C3F3342737179095" modified="2021-06-02" version="1">MRVFLSFAKKDAKVADRLWKLLDEATAVDRVYEFRLWRFDEAILIGDDWDTRIRQALAVSELGVLALSNAFLGSGYITGVELPALVDVPGKHAFPLALRPVGDHTDWKGLDAKQIHGFRKPFEQVRGAARRDEWVNALVDQFHRVLTRDGKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T4</accession>
    <name>A0A7W7T2T4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="77"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="666" mass="70973" checksum="567C61E9D4AD7CEF" modified="2021-06-02" version="1">MNGSGGEAVRNEMPGVAHNVVQAGVVHGDFHLHGPSRPQPRQLPNPVDELINQVRVLAELGRGADDRPALDEPLVKVVVGPRGSGKTAVATHWMRSRDADFVDGTLYANLGAWTDHQVAPREVLGEFLVALGVARADLPGDLEGRAAEFRSRTHGRAVGVLLDDVVSAAQVRALLPGAGRSVVVATGHGAFGTLARGRTTLIDVDPLEDDMAPTLLRRFAGDRVDADPAATARLLALCEGLPVALCLVGGMLAERPDLTVAELLTELADSPLTSVAVGDDPTLAALFDLTWARLSPVAREVYRALGAHPTGDVPVAALRGVLPEAGLAAAIRELGTLRVVDKPVPDRLQVHALIREHAASRGGHVRFVDWYLTGVVTADDALMPRRPWRRRLFPDLCPDPAHPAAGTGARRWLEAERVNLRAAVADAHRRGLHAQTAAFCLVLWSLHEPGKFYDDLLAIAPLGLESARQLADPVVESVLLTQTGFAHLHLGAPDAAADACRRAVAVAAGEPEAEATALEGWGLAELDLGNVEAARDALRRNLALAERIADPRRHALARFHLAKAEPPEVALGLLAEALTTFRDSADARNVAKATLWQGRKTAELGRADEAAVLLREAETLAADWPFDRAQAVEARGVLDPAEYARAHALYVEHGFVRHAAAVGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3A2</accession>
    <name>A0A7W7T3A2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030591969" evidence="1">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="29399" checksum="BDEC604AF498775A" modified="2021-06-02" version="1">MRKLVLVVAVVVAAIAYLGVEPTSGAFNAKVTNSNNTVTSLAHTCTAVALADNPTRFYELNETTGTVAYDGSPTAANGTYQGGRQVQDAVEYPCLRETQPYAVLDNTHYVSTTGTITLSASTSSSHEAWFRTHDDLGGVISGIGDLATGASTKKDNMILLTSNGTIAFVTNNPSPYEIVTPFAYNDGAWHHVVGVHDATYGIRLYLDGQLIVQLAGAHPQSMTGYMRIGYDNTSGYANGFGSNQTTAHFRGNLAFMAYYPYALSAARISAHYAAGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C0</accession>
    <name>A0A7W7T3C0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="512" mass="53494" checksum="CA48488ACA18A922" modified="2021-06-02" version="1">MTEATGSRANREIGQAMTALMLGMFMAILASTIVSNALPRIIADLHGSQSVYTWVVTTELLAMTATVPLWGKLADLYSRKLLIQLSLGMFVAGSLIAGFSPNVEVLIASRVVQGLGAGGMTALATIVMAAMIPPREMGKYAGLFGAVFGVGTVAGPLIGGVLVDTSWLGWRWCFFIGVPFTLAAIVLLQRTLHLPVVRKEVKIDYLGAVLIVAGVSTLLVWSTLAGHQFAWWSAWTVVLVLAGLVLLGAAVFVESRAADPIVPLSIFRNRTVTLTTLASALVGVAMFGGTVFLSQYFQIGLGKTPTQAGLMSLPLIFGLLVSSTVAGQLITKWGRWKAFLVAGAVIMVGGMVLLATIDANTSVFVVSVHMAVLGVGVGMLMQNLVLAAQNDVPASDLGATTSTITFFRSLGGAIGVSALGAVLANRVTSLFAEKFPQAAGSGGTTEVPDLASLPEPVRAVVREVYATATAELFLIGTPIAVLAVVAVLFIKEKPLKTQSGDERLAEELAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L0</accession>
    <name>A0A7W7T3L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17811" checksum="17C38804292DD258" modified="2021-06-02" version="1">MGWWEAWTRWAAGDPTLKDAVLWGVKVLWWARIGKLMAFLAGLVLVVDIIGPERIVASVERRVAGGHLDRWRVDRRAARRGVIVFGGLFVLVLVGVVLRLDSGPLGILAIALVASVPALAAVNHLLPRFLTWLYLHDRVVTAIRTASLAAFVVGFHFDMLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W7</accession>
    <name>A0A7W7T3W7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10865" checksum="F0026DC5CE8D9CAB" modified="2021-06-02" version="1">MTVSKVSTDDVLARIRTLLGGRFGPEFDAVADDAVLSDALGDRYDSLGALECITAVEQEFGIEIDFVAHDVRHAFSRVDNMAGFVRDRLEDLEVFGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T402</accession>
    <name>A0A7W7T402_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blue pigment (Indigoidine) exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="145"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="30426" checksum="493EA294BEC9D585" modified="2021-06-02" version="1">MEASVRWGLVAAAAPIAWGGTYYVTRQTMPPDLPLWGAAVRALPAGLLLLAVRRERPRGVWWWRSFVLGTLNMGAFFALVYVAAQLLRTSVAATVMAVLPVVMMLLAWPLLGERPRFPPLLGGGFGVVGVVLLVSTGVDPVDPLGLAASVAAMLMSALGHILTKRWGSGHSVLSVTSWQLVAGGLVLLVAAFAVEGPPPAPTGKELLGIGYVSILATAFAYAAWFTALRHLEAGTVGLIGLLNPVTGVLLGTALAGELLTSRQIVGLVLVLGGVLLGQPVFARRRKSTVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T451</accession>
    <name>A0A7W7T451_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030803555" evidence="1">
        <location>
            <begin position="35"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="384" mass="40272" checksum="33D1B9D6B5ADFA7B" modified="2021-06-02" version="1">MIESRRRLLRLVLVPVVALATLIGVGMPAVAVPAAPPLPADATALSTPVIEPLGLFMASRGLDGSVLFSRGTPSTDSYTDFFSIGGQIIGDPTAVVSPEGAQVFARSTGNEAITSLVVSYSFPTAFQVIPGLRVSSEITAVRIPDRGAQPPMIRIFARGLDDGAIYTNLLIQGAPQGWVNLGGYATSEVTAAVTGPAGFTVNLRLVVRGSDNRLYSMVYNNTTGVVSSWAPIGDLVTLGNPTLSNGGATFDLRGNEVFVRGTNRAVFTWNFDSPGWVNLGGVSTSDVAVSISSDNGMQLHVRGTNNRIYLNRRPPGSTRFGGYVNLGGIATGNPAASGGSLITRRTVADQFIVRGTDNRMYGQIQVNYVGGFESYVAFGGPLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M6</accession>
    <name>A0A7W7T4M6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="39" mass="4667" checksum="949973F81838404E" modified="2021-06-02" version="1">MAERKNREQRSGVVRIVVMIVATIVRAIDLVDRFFFRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N3</accession>
    <name>A0A7W7T4N3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="670" mass="70908" checksum="5754160E871377C4" modified="2021-06-02" version="1">MDATEVGERREPGARARGLVVAAIMSAMLLSALDQTIVATALPTIVSDLGGGSHLSWVVTSYLLAETIMTVLIGKFGDLYGRKKTFVVSVLLFLVGSLFAGWADSMSTLIAARAVQGLGGGGLMVTAMAIIADVVPLRERGKFQGMAGAVFGVATVAGPLLGGLFVDHLTWRWAFFVNIPLGIVVIAVALAALPSIKTLEKPRIDYAGIALIALASTGLTLVTTWGGTEYDWLSPTILLMAAGSLVLLVAFVAVERRAAEPMLPMHLFRSRVFTVSGILSFVAGFAMLGGITYLPTYLQYVRGESATESGLWMLPLIGGLMGTALASGNVISRTGRYRVFPIVGSVLLAIGLLLMSRLDATTSYWLMGVFMVVLGAGIGLCMPVPMIVVQSTTNYADLGVATSGISFLRTIGSSFGVAVFGTIYAGSLPDRLAPAIAALPPGVDPRLVRSPQGVHALPPEVAAPVIDAYAETVQSMFLVAAPIGLVALVVAFFLEEVPLRDTTRAAATGNSGVGESFAPPTSASSRQELEKLVAKVVGSLGADPVPEVLARANVDISVAQGWLVGHFYRAAADRGYATMEHVAEFTDVPAGIFEPTARQLVDAGYLAEESGRYRFTPRGAELFERLVTGWHLWLVERLHDWNEPDRMEFSAALDAFAEDMIENGRTLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P4</accession>
    <name>A0A7W7T4P4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="170"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="375" mass="40370" checksum="39CF9D5F6F6C4050" modified="2021-06-02" version="1">MTTHRPRLRLAGVVAASAAVAFFAVVPARPEIDLFLVVSGMATAVPVVLARWWPLPAWLVLVAMVLFAPLVYGPHVDLVRAWGWPWTMGLALGLAYILYVVAETAERRVLVPVAVVTALAAGPHLPDWRDLSLVTVLVAGVLGFGDAVRMRRVAERRRLAERARTVALEERTRIARELHDVVSHHMSALVLRADAVTYRFPDLPPEVRAEFALLHRMARDGLVETRHVLTALRAPDDAAETAPQPGADDVAGMVESFRATGTPITLRTDFAGLPAAVGLSAYRIVQEALSNCARHAPGGAVTIDLVAHQSELLVSIVNTPGVRPASDTDPHRPRHGLVGMAERVRVLDGAFDAGPTDDGGFTVTARLPLRGLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U6</accession>
    <name>A0A7W7T4U6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23457" checksum="B8CF31B9E668BF18" modified="2021-06-02" version="1">MVTFTDFFETTFPGVLSRALMSSGDRHEVEDTVQDAYTEALRAWDRIAHYDSPEAWVARVVRQRLWRSAGRWRYRGPAVPGENAAWVAAQGDRGHARARAVLTALDGLPGRQRVVIVLHCLDGLGQQEIADELGIARGVVVGSIGKGRRTLENALVDPGSRRPLSAGSALPEAVSDPLADVLAATERWWADRVAADSRARERLLRAIVSRSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T558</accession>
    <name>A0A7W7T558_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20154" checksum="E302A5D2287B4B84" modified="2021-06-02" version="1">MGRPSQKEGILAAALGCFAELGYDATRVKHIAVRAGVAESALYRHYPGKEAIAHELYADHLGRYSAALEAIAGDGVDPVSQLGAVVDEVLAAYRRQPEAFTFTLLNTASVPLSLPPGTRFPLEIVEDVIRRGQRAGVVRAGAPNLLAAIFFGCLLRPLIVATLSPALDLVDTRHDAVLRDAALSAVTRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M0</accession>
    <name>A0A7W7T5M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein/non-ribosomal peptide synthase protein (TIGR01720 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="233"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1268"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2251"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3621"/>
            <end position="3695"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="5004"/>
            <end position="5078"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="6415"/>
            <end position="6490"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1303"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2286"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3656"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="5039"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="6450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="6740" mass="719586" checksum="979AAD2C6AC72B08" modified="2021-06-02" version="1">[encoded data, 6740 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Q8</accession>
    <name>A0A7W7T6Q8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16098" checksum="E62E35C58A345F64" modified="2021-06-02" version="1">MEPVVGATPKVVRSEAEWRETLTPQEYAVLRQAGTERAWTGEYTDTKTEGVYSCRACDAELFRSDTKFDSHCGWPSFFSPLAGDSVLLREDRALGMVRTEVLCATCHSHLGHVFEGEGYATPTDQRYCINSISLRLVETTAGPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6U7</accession>
    <name>A0A7W7T6U7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="43281" checksum="6CC6F24BD21CE991" modified="2021-06-02" version="1">MVQLHGGGFLLFGPSDGTRLAAGGAVINVEVHYRLGIMGFFTAKELGEHAGNYAIQDQQEALRWVRRNISAFGGDPGNVTIYGASAGGSSVCAQLVSPASRGLFHKGIIQSGFYNSLRGKDTSWQAQDCKARWPSEEEAQAAGARFAAAVGCGGVADVAGCLRKVPAAKLVDQAGNGMGVASGTIAPVVDGVTIPLAPADAIRTGRLNRAVVMNGVARDDVQLAAAETPERYRELVREQYGEYADEVFARYPLERFPEPSPFLAYRTITADANSVCPSLRASRQLSRHLTVFLYQVDNPDSPPAGWLDQTKPNGAFHVSENSFLFAPVGTAWNPNQTVYGRQLVAQWTGFARTGNPTVPGTPLWTPFTRDDQRALALLPAGNSVLTGEIGEQHQCDFWDSVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T753</accession>
    <name>A0A7W7T753_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding beta-propeller fold protein YncE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="679" mass="73145" checksum="7005CF7BC675EB0B" modified="2021-06-02" version="1">MRTALLIATDTYTDPTFGALRAPALDAGELDGVLAHPDIGDFTTEVLVNASAQDVRERVDAVFGRADRDDLVLLYLSGHGVKDRSGGLYFAAPDTRHDLLASTSIPAAFVRGVIDRSKARKVVVWLDCCYGGAFPTGMSPRAAGQVDVLDQLDDGRGCVIMTSATHVQYAYEPDGSVRDETGPSVFTRAIVEGLRTGAADLDGDGEVSTADLYAYVYERLRRESPDQTPTTSGMIAGDLRIAHVGVRLPAGLPDELRRLVRSTDPEFRALGLRLLAERADTGDDVAARTLDLLKGDDTPTPARESDHLKRCAMLWSNAAGVAFSPDSSLFAASGIVWDTVAWQEVHSIRGLNPGEAAFSPDGTLLAQGLRLGPALYSTTSWTLKTRARSTKSWPDRSGRLSFGHDGRLIVQWAPGHKPVLWVSAGNRWQERPLPVDHLRSLHLSRSTPLLVTLAVDGVVEVFDTTTRRPTGGPSVPEPAATAVAISPDGRLLAVADDQRTELRRTSDRQVVTTLPRGVTDWRGLAFAPDGRLLATVDLDGVRLWSVPSGNPVQSLHTELTHIEFSPDGRFLAGIAGNGQVWLWSVDPRDLATLPERRACPPTTRERRARLRHIDKIAGRTRVATGAAGLSGTVAVLDAWFSVTALVLASIGLLTLVLAVPEAVRWTLAQDLRPGGRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A1</accession>
    <name>A0A7W7T7A1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain containing-hemolysin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_005232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="430" mass="46370" checksum="C9AC7F8DDB461CC1" modified="2021-06-02" version="1">MWSSSGLLVLAVLLVLAAGAFAGADAALGTVSRARVEALHRQGDRVGTGQLIQVLTDRPRHVNLLLLLRLGCELSATVLVTVVSLRTIETGWLAVSVAGLAMLVVSYVLVGVGPRTIGRQHPYAVSLLAAGPVRVLGRLLGPLSRLLILVGNAITPGKGFREGPFSSEVELRELVDMAQERGVVDEGEREMIHSVFQLGDTIAREVMVPRTEIVWIERTKSVRQALALSLRTGYTRVPVIGESVDDVLGVVNLKDLVRHTLAGEPDDTAVSGLMRQGSFIPDSKPIADLLREMQLTRNHLAIVVDEYGGTAGLLTIEDILEEIVGEITDESDKDDRPPVEHLTDGSVRVSARLPVDDLDALFGTELDDHEVETVGGLLAQRLGRVPLPGTEAEIEGLRLRAEGGKDERGRMRITTVLVRPVTDDEETPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V6</accession>
    <name>A0A7W7T7V6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5748" checksum="ADA2F7F8219DA803" modified="2021-06-02" version="1">MAETYNGYCVKCREKRDFPGEIHESNNRRMAKGKCPVCGTTVTRILGKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T807</accession>
    <name>A0A7W7T807_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="161"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="222"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="501" mass="53261" checksum="DF9FDB8FC2B0C84E" modified="2021-06-02" version="1">MSVRPGPEDPDEAPGLRTVSLRRRVTLSALGVLAVVLIGVVLLVDALFTVQSGRDVDALLAERGRVAQQLVKQGRLDGEELVARLAGRGIQVRVVLPDGTVYGDPPTDKRIDKVFPDGTRVTLYADQAVLAGPQARLRRLLVVVGLGALGVAAVALVLVIRRALGPLDAMTTLAKSIAGGHRGYRLNPARTDNELGRTAAAFDDMLDSLEGSEERTKRFVADAAHELRTPIAGVQAVAEALVQAGGAEEREELNLLLVREARRAGRLVDDLLSLARIDAGLELHREPVDLLALAEAEATRTRLVAPEFDIAAEGTTAYVDGDPQRLAQVLVNLADNARQATGHGGTVRIRVSTPGAFAHLTVSDNGPGVPPDDRERIFDRLVRLDKARDRRSGGSGLGLSIARGVVRAHGGELLCATPESSGATFLVRLPLTDHPTRPDRPSPATHPMPTDHPPRSDHPGQADHPPRAGHPPRTPHPGSADRSAPMDQLHADSSPGPTSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N6</accession>
    <name>A0A7W7T8N6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="34" mass="3727" checksum="A20DBE0254AE84B2" modified="2021-06-02" version="1">MTRDVYMIRMAVGGNAGGSEQHKAPDLYMQVRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8R4</accession>
    <name>A0A7W7T8R4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arthrofactin-type cyclic lipopeptide synthetase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="693"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="773" mass="83747" checksum="D8C8CD18488989D7" modified="2021-06-02" version="1">MSTSQSTSLPLARATGADRTGAAHRRPVILPDDRPWTSQDTAAVAALAALIHRYTGQTSVVIRRGVAGAVRLAVTGDQTLSQLRYAVDTTVVEPAEDGDFQAAVTDRAEHATAALTVLSGQTGLTLLAARAEFGADAADQYALHLGRVLAAAPDVKVRDVVLLDDADLHRMLVEWNDTDEEVPGGFFHEEIAAIARRTPDADAVVWPGGRLSFGELDDRSTQLAHRLRSLGVKRGDNVGTCFPRGPESLIAQIACFKLGAAAILLDPDFPADRVRFMIRNASAVLVLTMREHKHVVSGDTRVLALDAADWRTEPTTPVDVEVEADDFIHICYTSGSTGVPKAVLVRHGAARNLIHSMRTLCGITSESRGTWLAAPGYGMVEVECFSVLAAGAPVRIPEPSVVTSPEWLRDWFVTERITHTLLMKAVCERILTLDWPAETALHNIRICGERVQSWPDASLPFQVLNLYGSAEATVVAICDITELGRVLGEDGRARRTPPIGKPTPNVRTFVLGDDLKPVPPGVVGQLAVTGDSLSAGYLDQPEATAEKWIANPIDPDRHPILYLTGDLARYWPDGDIEIVGRTDNQVKVRGNRVHLGEIEAVLAGLPGVGQAAVLAKTDDKGDTRLVAYLEASPGEEPAVRGIRAALKQKLPTFMVPSAYVVGVFELSTNGKIDRNALPEPPRTRPDVDTDYQEPRDEFERALQEIWEQALDLEAVGVLDNFFDLGGDSMRAATLTARIGERFKVEKGQDELFFELFDQPSIEGMARALASMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W1</accession>
    <name>A0A7W7T8W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CspA family cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14605" checksum="AD680E889D3B0E46" modified="2021-06-02" version="1">MSEVPTGKVKWYDSEKGFGFVTQDGGEDVYVRKSALPPGVEALKAGQRIEFGMAEGRRGPQALSVRLIDPAPSVVEARRRPAEELHGLVDDMIKLLELKVQPELRRGRYPDRKNVKLIAEVVRAVARELDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T940</accession>
    <name>A0A7W7T940_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">F4559_006202</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="16288" checksum="B573167641C10DE6" modified="2021-06-02" version="1">MRVGIGTDVHPIESGRECRLAGLLWEGVDGCAGHSDGDVAAHALCDALLSAAGLGDLGAVFGTGDPRWAGRPGVDFLAEVRRLLAGRGFRVGNAVVQVICNAPKIGKRRAEAEEVLSAAVGGPVSVSGTTTDGLGLTGRGEGIAAVATALLVPLDEARVPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T967</accession>
    <name>A0A7W7T967_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="28730" checksum="A23E017BDCFFA4F4" modified="2021-06-02" version="1">MTLPRPDHCVVMGVVNVTPDSFSDGGRYLDVDDAIAHGVALFRRGADVIDVGGESTRPGAGRVSPSVEAERVAPVIRSLAAEGVPVSVDTTRSEVALAALEAGATIVNDVSGGLADPRMASVVADAGVPYVLMHWRGHSREMDRLAAYDDVVKDVREELAARVDAALAAGVRPELIVLDPGLGFAKTAEHNWQLLHRLDELMSLGHPVLVGASRKRFLGALLGGREPDGREDATAAVSTLAAYLGVWGVRVHDVERTLDAVAVARAWRTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9E4</accession>
    <name>A0A7W7T9E4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15824" checksum="8DA0339B84B086B1" modified="2021-06-02" version="1">MQENELRTEITISAPVAVVWAVLVDFPRYAEWNSQIAYVSGAAVAGTPVRTRAAWGSPAEREFEGVITDVEENALLASEGGDPELFFGRHRWELAPVDGGTLLVNRETWTGPLAASVYAESADLLRSEFTTFNQALASEAARVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R5</accession>
    <name>A0A7W7T9R5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="45131" checksum="5285157AA25C25F5" modified="2021-06-02" version="1">MGGYGWSPRGNHGEVARRLRAHCLVLWDDDVPHVLLRADVISFPRDVHRAIWDAVVEEGLVESDRFLLAGSHTHSGACLGDTRPDPRILMGLNDADVDAVDGSTGIVVDRLVQLVRDTADQERTEVVLGFGVGSAEIGFNRVGLSTVLSDVPVLLVRDLDDDPFAVLFGAACHPVSRGNDSVFDSDYPGAAAEAIEDELGVPALFFLGAAGDQDPDGSLGPPLVEEIGDAVASAVLDVVGDSTSPVTGPIRVVSAEVRLPLSVDLSDPRVAARLRGRYEDRLADPAVEVRRHAEAIIGLADDDDLPTFAPMPIQVWRFDGLAIAALSHEVLSSYDVTLHERFPEPLWVLAYSGEVECYVPDEECLAQGGYEAGWTDDNTIAGEGSATMPYRWPVPFEEGIESTIVDTTLTLLDVLAARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R8</accession>
    <name>A0A7W7T9R8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7597" checksum="8027963628E04E43" modified="2021-06-02" version="1">MAPDMVRVHVTADLPIRPVALPFADRVELRFGKAFPAVLVVDRGALPRLMAALAEAQSALESKEPESGGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB8</accession>
    <name>A0A7W7TAB8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="8" type="ORF">F4559_006807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22469" checksum="37F079C0186A8C6E" modified="2021-06-02" version="1">MTAPDEHPPVVVTDRRRVDPETGQVRTPEAGTDVDQPEPVDAEVVDAAPVEPDPAAELKAQLDERTSDLQRLTAEYANYRKRVERDRELVVATAKAQVANELLGVLDDVERAEAHGDLTGAFKAVADKLTAALRGSGLESFGHDGEAFDPSVHEAVQHGTSPDVSGPTVTAVLRRGYRFGERVLRPALVAVTDYEAPASESPAPAEESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAT2</accession>
    <name>A0A7W7TAT2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20958" checksum="182ADA1E48A675D8" modified="2021-06-02" version="1">MANTVEKHSESDHTKFHHLLREQVGHEFAAAQQYLAIAVWYDGADLPRLAAHFYRQALEERNHALMIVQYLMDKDVRVSIPGVSEVRNDFTDAREPVELALHQEETVTEQIVTLAKTARDEGDYIGEQFLQWFLKEQVEEVASMRTLLAVVDRADGNLFHVEAYLTRESVGEAADPSAPRAAGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCC6</accession>
    <name>A0A7W7TCC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d ubiquinol oxidase subunit I</fullName>
            <ecNumber evidence="13">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_006524</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4969165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="488" mass="53551" checksum="400B5D31DE7630CB" modified="2021-06-02" version="1">MDVLDLARWQFGITTVYHFLMVPLTIGLSLLVAGMQTAWVRTGDRKYLAMTKFWGKLLLINFAMGVVTGIVQEFQFGMAWSAYSRFVGDVFGAPLAMEGLVAFFVESTFLGLWIFGWDRLPKRVHLACAWAFSLATIASAYFILAANSWMQHPVGIVLEDGRPRLTSIWAVLTNNTTLAAFPHTIFGAFAVAAAFLVGIGAWHLWRRRADEPVWRSSIKLGTWVGVVAFAGLSITGDIQGKLMFEQQPMKMAAAEALCHTESPASFSIFAVGDVSRPDCENVKSITVPALLSFLAHNDFTTEVKGVEELVPLYQEKYGTNYPVDERLGELSGKPIDYVPALPVTYWGFRLMIGFGAIGAGVGLLVLWLTRGGRNPRGRWFPILALSSIATPFLANSFGWIFTEMGRQPFVVVPNPSGVDGVWMFTARAVSNSTPGEVLTSLVALTLVYGLLAVVEVFLLRRYIRAGVAGVLPPDKPDKPADDVLSFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT57</accession>
    <name>A0A7W7WT57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="459"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="601"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="870" mass="94543" checksum="CD6E0366EF3D1195" modified="2021-06-02" version="1">MSDHASAAASSTPTRSTNRAFSAFAVLLLIAGVAAAYAVGDWLREDALDLDRLFWVGPLLVVGFLLAEQLAINVDVRSGDAWTISFTEIPLVLGLLVAPFEVVLAAHVVAGVGTLLARRVLDRAVYNAGLMFMEIAVAFAVAKSVEDFLGGRGPMWAGAFVGTIAVPLLASLLGLTALRLLGNGMRVGPSVRLVLQTLVVALLNTSAGLVGYEIATRAPWGGLLILLVFAGITAIYLAYSALLREQRDLEALGEVSLRVARSGRHATGPRGPGSGNAVDDGRAEDDEWQSIAERIRDQLDAGRVVLRLRTDPQTPMRTLVVGEPLPPGLRREDPRLLREDALLQLPGTEVRYFRVGEGGDDVTDALGRREAQEALVVPLRAGTQLLGVVEAHDRLSRWRGFGKADIQLLRTLASHLSTAVDNRRLLARLRHDAYHDPLTGLLNRPGLREATGEPMRQADLAVVVRVDLDVLSTVSDALGQVWGNQMLVTAGRRLRDELGPEVPLARLEGGSFAALLLDRTAERIEEIAERLRNALSVPYPVERFTVEASAVVGWASTADCEVEDPDADALLQRADVAVSATNENNPLRAYAPSMGQMFLRRFQLVTQFRSAVENGQISVHYQPKVALPSRQVVGAEALVRWKHPEFGRVDPDEFVPAVEATGLVDVLTDFVMDKAMERVRLWLDRDLRMSVAVNLSVRTLADEEFPDRVGRALVRHGVPPELLTFELTESGVMADPERALPVLRRLHTMGVVLAVDDFGTGYSSLAYLRQLPVDEVKIDKSFVLGMGTDLGDMAVVRSIVELGHSLGLTVVAEGVEDDAARDQLVGMGCDVAQGYLISRPLSEDRFEAWLRARTVQVRGARDETVLTLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT70</accession>
    <name>A0A7W7WT70_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain acyl-CoA synthetase</fullName>
            <ecNumber evidence="3">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="393"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="479" mass="49686" checksum="A6A88363722FD200" modified="2021-06-02" version="1">MTTPARNVADLVRGAAHRGPKHVALVDVTSGLSLTWSEIDALADAEAHRLVAAGVEPGDRVLVRLPTGPAFAVAVFGALRAGAVLVPVGPNHPEAETRRALADSGARLVVDAGHPPADAPGEPFETRGGGEDLAVLAYTSGTSGVPRGAMLTHRALLANITQCATLRPAPVTAGDRVLLALPLFHVYGLGPGLFQVAGAGATAVLLERFDADSALTAIAEHRVTTVVGVPPMYQAILAEPVERLRTDLATVRLFTSGAAPLSPGLLVELWQAVGLPVFEGYGLTETGPVLTTTLGGAPKPGSVGRPLPGVDVRLVDSDGRPIGEDDENGTGLVAARGDNLFSGYWPDGVDGPDADGWFRTGDVGYLDGEGDLHLVDRAGDLIIVNGFNVYPHEVERVLCQLDGVVEAAAVGVRDERTGETVKAVLVPAEGVTLTEDAVKEHCATRLAKFKVPTVVEFATALPHSPTGKLARSRLRLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT89</accession>
    <name>A0A7W7WT89_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter (DMT)-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="150"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="31956" checksum="E9F4C5C0188B0F5C" modified="2021-06-02" version="1">MNNRGTLVRLGVLALLWGSSYFWIKIALTGFSPVQIAFGRTVLGALVLVALAYSRGHRLTRDRRVWGHLAVAALFANLIPFVLFGIGEQSVDSGVAGVLNATTPLWTLTLGLALGFERNRNPVRLAGLLLGFVGTLLIFAPWQKGGLASWGALACLAAAASYAVAYTYIGRTLSGRGLSSIGLSSAQLVAATGLTAVVVPVGGLQPMHPDWRSVLAVVILGVFGTGLAYMINYRLIEDEGPTNATTVGYLLPVVSVLLGAAVLDEELNLRVVAGMLVVLVGVALTRRQPATAVTPVEEPATTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT96</accession>
    <name>A0A7W7WT96_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">F4559_000345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="40786" checksum="6970E7B68B093C29" modified="2021-06-02" version="1">MDLYEYQAKDLFAAHDVPVLPGDVASTPAEAKAIAERFGQTVVVKAQVKTGGRGKAGGVKLATTPDETQEKAEAILGLDIKGHIVHRVLVTPASDIAEEYYFSFLLDRANRTFLAMASVEGGMDIEEVAATKPEALAKVPVDAIKGVDRAKADEIVAAAKFPAEVADQVADVIVQLWDTFVSEDATLVEVNPLVRDPEGKIVALDGKVTLDTNADFRHPAHAELVDKQAEDPLEAKAKEKGLNYVKLEGQVGIIGNGAGLVMSTLDVVAYAGEKHKGVKPANFLDIGGGASAEVMANGLDIILGDPDVRSVFVNVFGGITACDAVANGIVQALQILGDSATKPLVVRLDGNNVEEGRRILADANHPLVTVVDTMDNAADKAAELAAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTF1</accession>
    <name>A0A7W7WTF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10459" checksum="ADF0C94B675E72C1" modified="2021-06-02" version="1">MTGFRTDLDRLERGAADFGEYAERAAKIGSTLGGVLDSLGACWGDDAVGQSFASSHVTPASGTVTGLGDIGTGFSGVGERFADTARTYRTAEQGNSTSFGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTF6</accession>
    <name>A0A7W7WTF6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15676" checksum="1E66A8F7BF42E1A6" modified="2021-06-02" version="1">MSFTAVWPITDPHDTEAADELTVTAPEDVDTLLTRLAEPGAGPAVIEHQDRELLDDTEGLLGEPGATKLPDHDMAVAVGDGFGYLTYADPDNDYSTLHGDAASPEYRSEYVDYPAGSGVPIETLGSALKDFLTTAQRPENVRWTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTL8</accession>
    <name>A0A7W7WTL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Osmoprotectant transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030882533" evidence="2">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="38"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="30418" checksum="1595786576F4883D" modified="2021-06-02" version="1">MKRTMAVIVTAAALLVSACGSKEDLSGASQQTASGGGEVVVGSADFTENKILAEIYAGALRTTGANVTVKSGIGARELVVKALQDKSLGVVPEYTGNLLNYFDKANTTTESAEVYTALKAKTPAGLEVLEKAEAEDKDALVVTKETAAGGVKSIADLGDGKYVLGAAGEWAQRWQTKIKDVYGVSFKEIKTTDAGGPVTVDALKNGSAQVVNLYTTSADIAANGFVALEDPKSLYPAQNVVPLLRSDAVDAKGKEALNKVSKGLTTAKLADLVKKVDVDKESVAKVAASFLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTW7</accession>
    <name>A0A7W7WTW7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prmC</name>
        <name evidence="9" type="ORF">F4559_000933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="101"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="191"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30013" checksum="9FAFD48244A31ECB" modified="2021-06-02" version="1">MTRHPLRAALQEAERMLAAAGVDSPRVDAELLAAHVLGVSRSRLPLIPLVDPAVVDALHKLVLARQTRVPLQHLTGAVHMGGIDLAVGPGVFIPRPETEYLLDRVLSTVDFSVAVDLCTGSGALALALAHNRPGAIVHAVERDATALSWARRNADARAAAGDTPIRLHSGDVTAPDVLADLEGTADLVVCNPPYVPDDTPVQPEVADHDPRQAVFGGPDGLDVIRHVVGLAARLLKPGGWVAIEHDDTHGESVPALLAARRVLTDVEGHLDLAGRPRFATARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU72</accession>
    <name>A0A7W7WU72_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22880" checksum="B3D28BEB9D413F06" modified="2021-06-02" version="1">MTTYTVTRRRSVGVWWLALSAAAIAVYAPLPYLTGSLEQIASDGTGLAEHYLKQPDWVRVAMYLHIVFSGVALLLSPAQLSARIRARAPGVHRVVGRITLTAMVVGGLGGLALAPYGYEGVPGALGFGLLAILSVVFPLLGLRAVRAGRIAEHRRWMIRAFALIYAGVTLRVWMIVLTAAGLEFDEGYPLMPFGCWVPNLLVAELVLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD2</accession>
    <name>A0A7W7WUD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18521" checksum="DC68390BD941040B" modified="2021-06-02" version="1">MTSQPLPFDPIARAAELWEKRIGPSTAMAAVTSVMRVQQIIQSAVDAALKPHGLTFARFEALVLLTFSRAGHLPMRVMGERLQLHPTSVTNIVDRLEADGLVRRLPHPTDRRTTLVEITDEGHERREAATGSVIEVDFGLVGLTDRQTDQLTELLSRVRRTAGDFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD6</accession>
    <name>A0A7W7WUD6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13858" checksum="7BAF697C930320C9" modified="2021-06-02" version="1">MSAESFLDEARRELRRVTPEELVGLTDAFVVDIRPVHNRLAEGEIPGSVPVERIVLEWRLDPHGDHRIPGFTADSTVVVLCNEGYASSLAARDLRRVGLPNATDLVGGFRAYAAAGLPVREGATPAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM8</accession>
    <name>A0A7W7WUM8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="100"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25766" checksum="2EAA6D9763D045C2" modified="2021-06-02" version="1">MIEERLTGGNITEVVVRVGDTVRRSPGPEFAVRVLEHLEAVGYPYAPRHLGTDERGRDVLTFVPGHTTDHPSQRAEGAYALAGTMLRRLHDVTTGHPLAGDRECVVHGDAGPYNTIVHDGLPVAFVDWDGCRPGDRIDDLGYLAWTWCVLASGTVPVADQAAHLRELRAGYGEVDPDDLVAAMVRQQTRLADLEQATLDNPAFGQARRDHARRAVEWAVASRDLVLRHENLFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN6</accession>
    <name>A0A7W7WUN6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33935" checksum="72C65EA7C25BF55B" modified="2021-06-02" version="1">MARSSLTDRLVDLRRGYTGENLSQAVPAVRAALHADDVRRRVAAALDGVGTARGLVLPDAEDDAQRALECVVFQAGTDAGAHLQLRPPASMLRPAHAFRAAEPGPLSRLHLTGYALGPLLFELLPREEDGWLAGVPGLRTRQHPRSLELVLLDTEASVVFAGVDARRFAEGMDYVRTLMTGRGLTGVFVDGPLSAAERDHLAEFPRPTGLGSALLRRPHLFADTPWVRSWSQGDTWWVEWPESVGVTGVVDRLLDPVFGFANVREVPGVAGGLGLSDGWRELFLRVVDGPDPAHEEALAAADWPEGVTGWGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR7</accession>
    <name>A0A7W7WUR7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Meth_synt_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="36983" checksum="EC8124722AD897A1" modified="2021-06-02" version="1">MDVSPWPEGTATGIGSLPGADPLEAARVVLGELPQLPHLPELPGRGVGADLVGRTAGLLVDLPVEVVPSGYRTAAHPGRDHRRAVDLLRRDLDAFEEALETSGARPEVVKVQAAGPWTLTASIELNRGHRVLTDRGALREYAESLAEGLRRHVAEVAKRIGARVVVQLDEPGLPAVLRGLLPTPSKLGTVPAVHEPEALAVLRPVIEALGPDVVVHCCAPKPPIGLLRRAGVRAVALDVGLLDESSWDEVGEAWEERTTLFLGLVPSTDPAAPVDLAGVAKPALDLVDRLGFPRETLARYAVPTPTCGLAGASAKWTRRALSLSRDLGRAFVEPPENWRRAEEGREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT4</accession>
    <name>A0A7W7WUT4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="183"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="479" mass="51474" checksum="56D14C124442570E" modified="2021-06-02" version="1">MTTSEAPARIAVTGLAVMGSNLARNLARHGYRVAVHNRTPARTKALMREHGHEGEFVPAETLSELVESLATPRQIIIMVKAGTPTDAVIDELAPLLGPGDMVIDGGNAHFADTRRREAALRERGLHFVGAGISGGEEGALNGPSIMPGGSAESYKHVGPVLESIAAQVDGVPCCVHVGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLHRVGGRGPAEVGEVFRDWDRGDLESYLVEITAEVLGHVDPDTGAALVDVIADEAEQKGTGRWTVQEALELGVPVTGIAEAVFARSLSGRVGQRAAARAAFGASEVIPSPDDDLVEDVRLALYASKVVAYAQGFDQMRAASVEYGWDLDLGAAATIWRGGCIIRARFLDRIREAYDRNPDLPSLLVDDYFRDAVVRAEQAWRRVVVKAINAGVPVPGFVSALAYYDALRSERLPAALVQGLRDFFGAHTYRRVDREGSFHTLWSGDRSQVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV7</accession>
    <name>A0A7W7WUV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation/acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="525" mass="54989" checksum="D9CDD511A062A620" modified="2021-06-02" version="1">MTGANIALNVGVFVVFVLITLFIVYKAGSRNATASDYYAAGSSFTGPQNGVALSGDFLSAASFLGISGSIAVNGYDGFLYSVGWVVSWLLGLMVISERLRNTGRFTLGDVLAFRMRQRPVRAAAANVTLVISLFYMIAQMAGAGALMALLLDVHTAGGQALVIAVVGVIMVLYVLLGGMKGTTWVQIIKAVLLIVCVTLMTVFLLGKFGFSLSAIFDEASLNSSLGPDILQPGARYGGEPMDRLDFVSLALALVLGTACLPHVLMRFYTVPNAREARRSVVWATWMIGIFYLCTLVIGFGSLALVGSTTIAEAPGGENSAAPLLAFRIGGAVLLGIVCAVAFATILAVVAGLTLTASASFAHDVYANVIKRGKADPHEEVKVARLTAVVVGVLAIAGGIAANGQNVAFLVALAFALAASANLSTIVYSMFWKRFNTNGTLWAIYGGLGSCIVLIVFSPSVSGERTSIFPDADFAWFPLGNPGLVSIPLSFLFGYLGTILSRETPDEARTAEMEVRSVTGIGAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX6</accession>
    <name>A0A7W7WUX6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain acyl-CoA synthetase</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="540" mass="58441" checksum="D64DA7647DA6F056" modified="2021-06-02" version="1">MARSIPDLLRERVRQTPDREAFRHRVDGGWKSLTWADVDREVRGLALGYRALGVRDGARVAIMATTSVGWILTDLAVLAAGGVTTTVYPNNSAEECAHIVSDSGSVIVAVDRELADKVPAGVRTVVIGAEDFPAAEGDYDAMVDELAPEHLATLIYTSGTTGTPKGVELTHDNWLHTGESIAEVDILRPDDLHFLWLPMSHAFGKVLQVGVIAVGTPTAVDGSADRIAENLLELRPTIVAGAPRIFEKIHQRVVAAVRADGGVKRLLFEWAVKVARRPSSGRLSRAIADRLVFSKLRDRVGGRIRYFVSGSAPLSEDVGRFFAGAGLTILEGYGLTESSAASFINRPEDPEFGTVGRPLPGTLVKIADDGEVLIGGRGVMRGYHGLPEETAKTLVDGWLRTGDIGELDAAGRLRITDRKKDLIKTSGGKYVAPQAVATRIKAASPYIGHVLVHGDQRRYVVALVTLDPDTTPAGLDADAEVRRAVDEANAGLARHETVKRFAVLPRDFSVEDGTLTASMKLRRREIEDRYREVLDSLYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV16</accession>
    <name>A0A7W7WV16_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="276" mass="29208" checksum="FF56D907DA3EFAFC" modified="2021-06-02" version="1">MNGRTTAVRAGVRRGRIEFGHGVTNVPELIGWLWLPVLALVVLSFLDGDSGIPVGSRAVPGVLGMNVLFTAVLGLAVALVTDREDGTLLRARATPNGVLGYLVGRVAAKALMTLLTLVLVLVPGVLLFDGVAIERPVTLVWVVVLGLVATLPLGAALGALFANPQSLGFITMLLFLLMAVSGVFQPLTSLPGWLQVVGQAFPIYWLGLGMRSALVPDAWVVAEVGGSWRPWETVLALGLWTVLGFALALPALRRAARRESGSRVAARRQKALNRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV60</accession>
    <name>A0A7W7WV60_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding LacI/PurR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="335" mass="35591" checksum="873DB887A7CF68B0" modified="2021-06-02" version="1">MSVPPHSGPRPTLEDVAARAGVSRATASRVLNSSPRVSRAAHDAVTAAVAELGYQPNRAARTLVTRRTDAVAVVFSESEPTDDHRLAWLIRATAAALADADVQMVLLLVRTSEDLARAERVLTGGHVDGALVFAPRKGDRLVPMARRLALPVVFAGRPWGPTRGLHVVDHDHEGGGALAAEHLVASGRTRIVAVGGPRDVHPAADRLAGARDVLDACPVEDGGSTRDGARRAMAELLRRVPDLDGVFAVSDHLASGVLDALREAGRRVPEDVAVVGFDDDPTVAPHTVPPLTSVRQDVEAQVAGMVTQVLRLLRDDPVRPRREILPTTLVRRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD0</accession>
    <name>A0A7W7WVD0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030697165" evidence="1">
        <location>
            <begin position="28"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29519" checksum="ACCF64F7E5D3D2DB" modified="2021-06-02" version="1">MRRRSMLAGVATTVGGMIAAGTGTAGAAGAPGLRDHRLVSLSHVNDPDRTNVYPGDPAFKLTTITTVPEDGFYLQYVEQGEHTGTHWGAPAHFNSDEPAADELDVEDLFLPAVKIDVRDKARRDADYEVTVDDLQRWERKHGRIPNEAAVILWTGWEDRWGTPAFYNYDTQGRMHQPGFSLAAVQWLVRTGRLGRRGALGTDTFSPESALDAEYRVSKLLYREHRISLEILANLAKLPETGAHVLVGGTINRRGSGSPATVFAFVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK0</accession>
    <name>A0A7W7WVK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="414" mass="41647" checksum="FB74FA529D15309D" modified="2021-06-02" version="1">MREKAVKEGETQAVTRPGDLAMVRALAPVLLASAVSLLPYTVYGTFLVAIAHDTGGGIAAVGGLRGLGGLAALAVGALVAPLLDRLPRMRVAAIGLALIALGSLVGALAEFLALVVFSLVLGAGMAVLSPALGAAAADRFGGGPAAGRAATLVNAAQSATVMLAAPLVVAPALLWGWRGDLLALAVLALALAVWFLRDRTPPPGTDVRLGYLASFRALVDLRPLLLVAFLRNATFMGYLSYLAALYDRYHLSAGQFAAVWTLSGASFFAGNLTAGRLVGRRVRADRLLTGSCVVVALGVTGIFFSPWVWSAAACSAVIAFTSSMAMASVVVLIVDRAPTGLRGAALGVNGAANSVGVFAGAAAGGVGLAVGGFPGMAAVFGTIGAVAVVTSHRFSRKVGISHTSGNHATAAPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL2</accession>
    <name>A0A7W7WVL2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19156" checksum="17BD6F119BED2FE7" modified="2021-06-02" version="1">MRDAAVERVSVVFSLFDANDSGKLDGEDFELMARRVVVAADGSGEPALREMVEAFRAYWATLVAELDVDGDGEVTFEEFRTCVLSPERFDATVARFADALAELGDPDGDGLIERSRFLALMKAIGFEEGKVHALFDAFGPSEDDLVAVDTWRRGIVDFYAPDKADIPGDLLVGGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ4</accession>
    <name>A0A7W7WVQ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="37661" checksum="5473CA4AA40690F1" modified="2021-06-02" version="1">MQLPDHRGPVGEILVDLLRRPPEPGDESILKEVLATEADSIAEEDLQHSLFVCYGLQYYLFDEAAQHWEWHAPLIGLRQRLEARFQRVLDEAVGPLPDLEVEELPGFLMELGKPRAGRSLSRYIKRDATIRQFEEFLMHRSVYSLMEADHHSLAIPRVRGGGKPALVEIQSDEYGGGIPGRLHSQLFELTLDELGLRTEFGAYFADVPAYSLATVNLISYFGTYGRRRGALLGNLAITEIGSHHVNRNFRNGLQRLNGSDSSWLFFQEHIVADAVHEQLAAHDMCGRFVRENPSELSDVVFGALATTELGGLANENILSSWERGESSLRTTTPAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS4</accession>
    <name>A0A7W7WVS4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiopeptide-type bacteriocin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="68"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="34583" checksum="A745DE00C69441ED" modified="2021-06-02" version="1">MPADRLTATCRTAAPAELAAAVLAVLAGADPGTVAAGHDLDSADLHDAVRTYRAAGLAALESAAENTWYQVRVRFADWSHAETAGATTLGPALYRLSADGAVAGWWFLRKHPCWRLRLLRADTAAVNGVLDELADAGVVARWWPTVYEPETIAFGGPAGMDTVHDLFCADSAGVLDYLRHDAPGLGRRELSILLLSGLMRAAGLDTFECGDVFDRVARLRPAPTDADTTRTGTLVDNLRVLLSITDLADSELFTPGGPVAHAAPWLAALRTAGQRLGHDAANGVLDRGLRAILTHLVIFHWNRFGLSATSQGILARAASTALLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX1</accession>
    <name>A0A7W7WVX1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15959" checksum="4CD6DC79522EE8B8" modified="2021-06-02" version="1">MHQYWRPGWPRHRIVWAVVVVAVAVGVLLPWDRGAITAFVLRSEWRGLLVFSASCGLGWVVHRLSAEREFTALAAAPLVFFSLFFGPAWWSVVGWALVLWLSIVVPKEHRTDEIIVPDHGTIRPTTAELFAYLEKKRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW18</accession>
    <name>A0A7W7WW18_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NDP-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27612" checksum="4848867B1F93F436" modified="2021-06-02" version="1">MHAVILAGGRGVRLRPYTTALPKPLVPIGEEYAILDIILQQLRAYGFDRATLAIGHLGSLIRAFVGDGSKWEIKVDYAEEKAPLSTIGPLLNFVDQLPEHFLVMNGDVLTDLDYTALLEHHVTSKAPLTVATYQRKVKIDFGTLATDDGGRIIDFVEKPVLSYGVSMGVYAMARKTLTPYPRNVPFGLDQLVLDLLSRGEEPAAFDFDGYWLDIGRPDDYDEANRCFEEVRSALLPTGRRPVPAPLDVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWN9</accession>
    <name>A0A7W7WWN9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="299"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1542" mass="165877" checksum="84081697F9E03EB2" modified="2021-06-02" version="1">MTDNTPKTNGTFVAVVLDEYRDPKFPKLEGAVTQVNDLATALTAYGYESQVVVRPLLVGVSVELDRWSEDWSARGQGGPAVVVWSGHAEGKDGKPLRLAAFDTARGTTNPNKYYSPVSLASHSLESGADQVLILLDTCHSGAGAIPALDQALDLLKDQTLPEGRVAWFGVLASCQADERAEGGRGRLLEAVLHLLTEGPRGSEEYRHEWSVRNEGITGATLIKAVLGDWQDGAQRAVDVSTGQPRAMFRNPLWRPKAGEALVEHLVLAAKGIDPTEEGWFFTGRQRALRQIVDWLAAKKAGMLLLTGSAGVGKSAVAGRIAALSDAAERADLMAHAPLTAEDPDPGDGSVDAAIHLRGMTVQSLAKDLADRLGLAVPRTPADLIAQLERADATTRQVLVLDGLDEAAPGEATPIAEQLLVPLSRLCTVLLASRDRPFQPHQEPGEALDSALTRTVGAAVHVLDLDQEQDTASDIATYVRDRLLADDVAPDKAAEIAPVLAARASTSSGGFLFARIVASRLAHTLAADPDLPWRERIPAGIEEALAADLATAPARLRDGRELSGAAHDLLTALAWAGGAGIPAHGVWQAVAQAVGGRDTTYEPEDIDWVLRQYGRYIVEDSDGYQAVYRLYHRELVTHLRTRTPAAVPVAIIRALVTLALGQTDNGTTPTQANPYLRQHLASHAVEASGPGVTALRELVELNPDAYLPNLAGALNNLANQLAGIGRRQEALTTAQEAVTTYRNLVELNPDAYLPNLATSLNNLANQLAGIGRRQEALTTAQEAVTTYRNLVELNPDAYLPNLAMSLHNLAVMMSGIGRRQEALAPAQEAVTTYRNLVELNPDAYLPNLAAALINLADQLAGIGRRQEALAPAQEAVTTYRNLVELNPDAYLPNLAMSLNNLAAMMSGIGRRQEALAPAQEAVRLRRNLVELNPDAYLPDLAMSLNNLAAMMSGIGRRQEALAPAQEAVRLRRNLVELNPDAYLPDLAMSLNNLANHLSEVGRRQEALTPAQEAVTTYRNLVELNPDAYLPNLAGALTNLANQLSEVGRRQEALTPAQEAVRLRRNLVELNPDAYLPDLAGALNNLANQLSEVGRRQEALTTAQEAVTTYRNLVELNPDAYLPDLAGALNNVANRLAGIGRQQEALTTAQEAVTTYRNLVELNPDAYLPNLAMSLNNLAAMMSGIGRRQEAVQIYDDIVTKSSGRPGLAAKVSYHRAVFLLETDQGEGVTELCRLLSSTKPEDNDTAFQIRRSLRQIAQADHEARKLVVRAHADHFPSSSEAPSWLDITDADLQLTVDWLSALTWRDSRDFITTHPELLEPPAQAALREWSTLGPANFHLALLERLVSGDPVDTVYRSLVLPEILIEWMSTASEGWAASAAYLTDHAEDLLTPDADASLAAIDDAGLVADVHRALLAVALDDGIDAAYELLQNRQVLHARVQKALAAADGATLRLLSAIEVGVYGDVWVGAVHWSTAWVLDDPEASDETAHAPEAVEVLREAVQAKAPDGDERNRMVAELAALMAARPARATALGDILQAVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX10</accession>
    <name>A0A7W7WX10_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase gamma subunit</fullName>
            <ecNumber evidence="15">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_003931</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="6"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4966572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="27157" checksum="9D805063447470E5" modified="2021-06-02" version="1">MSTLDVMLWVVVPYVAIAVFVGGHVWRYRYDKFGWTTRSSQLHEKRLLRLGSPLFHFGILFVALGHVGGLLVPKSWTEAVGVGETAYHVTAVGLGVIAGVCTVVGAAILIYRRRTVGPVFSTTTRNDKVMYVLLVGTILLGLGTTVLGNLTDHPHDYRESVSPWFRSIFTLSPDPELMASAPLGFRLHALAAWTLFAFWPFSRLVHVFSMPLGYLTRPYIVYRSRDDRLGSRPPRRGWERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX53</accession>
    <name>A0A7W7WX53_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7190" checksum="58A75E3EA58CFD89" modified="2021-06-02" version="1">MNQLAEAAGHPAVYVVLATIAGLVRLWIRHRTVVRREEEVTRRLEVAVRDTGSTERAAVVRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA5</accession>
    <name>A0A7W7WXA5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030590673" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="9945" checksum="4A23C6E22AB7F1ED" modified="2021-06-02" version="1">MSAVLFATLVGGQPAQAQPAAPAGPAPLVTCNTHLEFAGWYWGNCRGQAVIIKFRAFPTAPWTTLCVANGSDTYVSSVKEYYPEVEVLSGPCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC2</accession>
    <name>A0A7W7WXC2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS superfamily sulfate permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="408"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="502" mass="52285" checksum="D1A68F744A9B9EE7" modified="2021-06-02" version="1">MPLCLGIAVASGFPPIAGVLTAIVGGILGGLLGGAPLTIKGPAAGLIVIAVGSVHDLGQGDLVAGYRRALAVGVVAALLQIVFGLVRAAGIGVAMSPSVVHGMLAAIGVIIIAKQAHVVLGVKPQAQSNFGLIAEIPHSLATANPLILLIGVLSLLILFGLPMVRARWSKVVPAPLIVLAVAIPVGLLLHVDRPHDYELLGAHHLGPEYLVRLPGSLLDAITFPDFSQILSGTSIQYIVMFALIGTIESTLTVLAVDSMDPSKRPSNLNRDLLAIGAGNLTSSLIGGLPMISEIVRSKANLDSGAKSRWSNVTHGIVLLLFVALIPGIVQTIPLAALGAMLVYTGFRLASPHEFRHVTKIGLDQLALFLTTLIVTLATDLLVGVASGLALKIVLHLVRGVPLPAFVRPRPQVTRVGSVLRVRIPGAAVFPALLPLRRAIAKAGDDVTEVIVDVRDAAVVDHTFLSRLEELGKELPNATLTVEGLDDLVASSAHPQATRRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE9</accession>
    <name>A0A7W7WXE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35191" checksum="1384CB13E17E5A7A" modified="2021-06-02" version="1">MRSRSYLMILLGCLGLVCLAWLMWAMRHTPPPSLPVMVLVMLMAIGLAVVPWAVLVSARLADEEARALHLRGAFVAACTVTAGIWISLVVIRRESHLQTATAIVSVLAAGAVLLVGGVALPWLFLMARTLTRERAARIRAEERSEMAAHLHDSVLQSLTLIQKRSAQQEVRRLARSTERDLRSWLYGTKTDDPDDFAMAVTATAATIEDTFAITVEVVTVGTCRVDERTSAVVGAIREALTNAARHSGADKVSVYAEVVDIEMLVLIRDRGRGFTRKDTTSAHHRGIADSIEHRVRQYGGVAAIRSTPGEGTEVELRMIVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG0</accession>
    <name>A0A7W7WXG0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19902" checksum="EBECEAABD8C7190C" modified="2021-06-02" version="1">MSTTRDGLLAAAATAFERHGYARATIEDVCDLAGVTKGALYGHFGSKKELAIAVLERQATVWAKQVAQVKGSPLQALVDLGYAVHRDRARLLFQAPICEDVAERQVSLWRWMVRDLLHAAAAHGELRDEVVVDSCVEGILAGLVGVHLLSMSTDGSRGVFGTWRSWLPGIAQPTACANLRWVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN6</accession>
    <name>A0A7W7WXN6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phospho-beta-glucosidase</fullName>
            <ecNumber evidence="8">3.2.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.86" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008706">
        <property type="term" value="F:6-phospho-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103047">
        <property type="term" value="F:methyl beta-D-glucoside 6-phosphate glucohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="178"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="43591" checksum="5FDBB8E6969ED952" modified="2021-06-02" version="1">MRLVILGGGGFRVPLVHRVLANDDLVTDVVLHDVDADRLAAIGAVLDDRPHTTATTDLDEALTGADFVFSAIRVGGLAGRAIDEEVAHAHGVLGQETVGAGGIAYGLRTVPVADHIARRVAAIAPDAWVVDFTNPAGLVTEAMSRHLGDRVIGICDSPSGLCRRVAGALGVDGARFDYAGLNHLGWLQGVYVGDEDLLPRLLDDDAALRTFEEGRLFGGERLRALGMIPNEYLHYYYSTREAMGDGRGAFLLGQQEKFYSGEVDWETTRSEREATYMGGDRDTLDGGGYERVALALMRAIALDEPAELILNVRNGTTLSTVDEQAVVEVPCRVDARGARPHPVSPLPDDAAALVSAVKAVDRLVLAGTRDTALQAFARHPLVDSPTVARSLLDTYVDRHPELAYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP4</accession>
    <name>A0A7W7WXP4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="4"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="50290" checksum="49F0A0115591EA46" modified="2021-06-02" version="1">MSTSPLSVGQEALRFLHDLAPDSAAYNVAFAFGIRDEIDLDALAAAVRLTARRHDMLRSSFDDARGRVVHDDVVRLDVRRVDDEVLTDLVSAVITEPFRLREAPLIRFVLLVGPNETVFVMVAHHAVVDAGSQTVILRDLFAFYRSGADTELPELPATFADHVRAEIAVLESPRRAELVAYWRQAVAGAPFTLDLPTDRPRPPVQRYRGAAMLTRVPDDVVADLRAAARGVRVTPFVFLVTAFQLLLHRYSGQDDFLLGCVLSTKDRRMANVVGNFANPVLLRPRVGRATTFRELAEETSRQLRYATAHRDLPFALLPAELGVPQDRSRSALFQVVVSAYLAGGEDTLLDELFRGSTDFEYQGVRVAATTMPPQQTGQFDLTLELHMSRGAVGTVLKYSTDLFDESTIRRMAGHYHALLASAAADPDGVAARLSMVDGAERAELIAASAGATGEPLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXS0</accession>
    <name>A0A7W7WXS0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ORF">F4559_005014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="142"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="375"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4967655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="489" mass="53026" checksum="22B47EBC43217CCC" modified="2021-06-02" version="1">MTRTYQIRTFGCQMNVHDSERLAGLLEDSGYAPAAGDAAPDVVVFNTCAVRENADNKLYGTLGHLAPAKTANPDMQIAVGGCLAQKDQGEIVKRAPWVDVVFGTHNLGSLPALLERARHNREAQVEILDSLETFPSTLPARRDSAYSGWVSVSVGCNNTCTFCIVPSLRGKEKDRRPGEVLAEVRALVAEGVLEVTLLGQNVNSYGVEFGDRYAFGKLLRATGTIEGLERVRFTSPHPKDFTDDVIAAMAETPTVCHQLHMPLQSGSDRVLKEMRRSYRTGRYLSILENVRAAMPDAAITTDIIVGFPGETEEDFQATLDVVREARFTGAFTFQYSKRPGTPAASLPDQLPKQVVQERYDRLIAVQNAMSWELNKEQVGRRVELLVAAGEGRKDAETHRLSGRARDGRLVHFTPGDAAVRPGDVVETVVTYAAPHNLIADGRLLSHRRTLAGDRSEAGLKPKTAGVTLGLPSFGKPAPLPAPVGGCSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY83</accession>
    <name>A0A7W7WY83_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1290" mass="142522" checksum="BE23D06B30E2F3CC" modified="2021-06-02" version="1">MADGAWAADSPLWGLASDADRFGPPVLALARSLDSRRVRAEEVLAGDPWLDPDLAARMASHLAVDFELSGAEAALLVLAPMLHQVRVLEAAAAAVSVGPTSLREPGSADYARFLSGPEQRRLVDRTAARPEAGDGIGWWLFHQWVAGRPDRPAPLATGDRPLQPVLACLDRIEALFHLTPGDLRDDRRRGLEPVRSYLGFGPPQEVREELLGLLLVVARELAIGLTALPITVVEHLGIPNPVRLGELRTTIAEARWEPMEHVGVALLAHCRHEAVLESLRDHVRRTDAVLGAVRDVAVGVEVLKPLRSLPAHASADRIRPAEENGRPVFVVPVTRFRLEESRVRELLMGEQLYGDRSLAIRELYQNALDACRYRKARYDYQAVKHRSRALWEGRITFTQGREDGRYYLRCHDNGVGMGESELREVFSRAGARFADRPEFAEEQARWEAAGVELFPNSRFGIGVLSYFMLADEIEVRTRRMSRDGFDHGQPLRVMIAGPGHLFRIEPVDEDVEPGTTVTLYLRDGDAAPSCVDVLNRLLGLAEFATTATHDDLSAEWEPFRLEARPRGVEDGVTVSGMLVHSEPTEYGQVVWCEGGGGLLVDGIHAEPVHRRGVLSPPPLNSLGSRGAVVNLHHHAAPRLSVDRKSVLDDVSSQVESLLRDAARELVAADPVFLTHEWICDLAVDSPFVADIVTDEIASSGRPVWSAAGPIDMATVGCFPWDWARIRRLDAAGGPARTRFDHAALDEWLLLWRLLAHRGPEVLGVDFPHGRAVRSARPSDAAFLGVGSETTNDPRQVQVSDSTSAGYVLSVAAAYGIEPVVVAQRLAALGIDPGSSFTGGFDDPDRDSRLLSTHVEYRTSSWLDPRTPVSVGRFVYAHVRTGIPVEKLLDLFDRCGFDTRRVRTLPRRITRDDLTLVGVDLERGRPWLPDGHPVSVEHVCAAAAVLRWSPTRVTDRLAELGFSAPRVESLPDWAASATRPVLSCAALPMGGVVEVSQLVRASVLWDVPPREVARRFAEIGIPVPPADLLPDTLDERDRTLLSGTWLRRNTPPGPVRVGLRDLLDLAENTRVPVGEAWTRLAELKFDLPSSVIATQAYDEADRLLMRFSPAGEQRPHWETRRDFGFVLEAAREIGRSAAEIVRRLRRMGLEAPIWSWPDEPLTEIDYHTMGMIRSIRRMPLAGIARVSKKTGGEAVQVAERVRKLGYDVDPVPERLDPFSLALLDCFDRFDRFDMFGLDLRRPVTMRSVLDAALWFEIAPAEVVERLAALGLEVPDLAVELPKLLAKVPLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB5</accession>
    <name>A0A7W7WYB5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized SAM-binding protein YcdF (DUF218 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="49"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23863" checksum="6DF2272C11FAA25B" modified="2021-06-02" version="1">MPPASFPARVRRLVQRVVLGGLLIGFLVVGGTAFRVWQVAREDDRTHADMAVVLGAAQYNGVPSRALEARLEHARRLYDQGVVSYIATTGGRQPGDEYTEGEAGRIWLVEHGVPEDRVVEVGFGTDTLGSIRALADAARARDLKTAVIVSDPWHSLRARTMAEDQGLEAWTSPTRSGPNVQTRETQLYYIRRETFGLLYYHLMKAPVDVFDGITQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB6</accession>
    <name>A0A7W7WYB6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_005401</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4968042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24192" checksum="E4ADB46CFCE9B0AB" modified="2021-06-02" version="1">MFESFGSLLSSFAPPALAIVGLVVVVRLLMHPLSRAAVRAEKARAALAPDVRALQEKYGKDPVELQKKTMELYKENGTSLFAGCLPMLVQAPFFFFMYRLVTTPSPLLHDTLLGVPLDSHWLGTWAHTPVFLGLFALLTAVAFGTSRWQAAMAARSGGPRPPFAKVLRLLPFGTVVMAAFLPLAAGIYLLTTTTWTVTERAWLYRAIPTPPRAGAPARSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK3</accession>
    <name>A0A7W7WYK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="22952" checksum="3DF2992AF93BEFE2" modified="2021-06-02" version="1">MIKVMLADDEDLVRSGLRMILSSSGDIEVVAECDDGHLVADLARQHRPHVVLLDIRMRSSDGLMALRRLRAIPDPPRIAMLTTFDVDEYVSEALRLGASGFLLKDTEPEQLVKAVRDLARGGAVLDPGVAARVLAAVADGERAAEPARRLLASLSEREREVLVLIGQGMSNAEIGGTLHLSEATVKGYVSSVLGKIGAVNRVQAALVAFRGGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN3</accession>
    <name>A0A7W7WYN3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16308" checksum="EB7CFBB2DA5B9FD5" modified="2021-06-02" version="1">MSGRTPAGDVLTDVVMRTFRLYGALLDAAEEMTRPVGLTAAWWQVLGAVLRTPLPVSGIAREMSLARQSVQRIADLLVDKGLAEYRPNPAHRRAKLLSPTEAGYAAIAGLREVQHAWTKRITAGIDVADLRTTLSTMEKLVAALDADRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY2</accession>
    <name>A0A7W7WYY2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="120" mass="12583" checksum="117C9E36CFEFF5C6" modified="2021-06-02" version="1">MVVGALLGVGLGGAWWATREIIASGRVCSTDDWDCLAMALFAIPVSLVVGVVLAWLLLRAVREERALSMAAVGVTITAVLTFMTLWVEVPASGLVAGALGFMIAAPVTARHDVRHTATHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ74</accession>
    <name>A0A7W7WZ74_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21630" checksum="8681D0677DEBC6B5" modified="2021-06-02" version="1">MKVDGRLERGGQTRRQILRRAVDIASVEGLEGLSIGRLSTELEISKSGVFAHFGSKEELQLATVKAAAAIFVGQVVEPALALPEGLVRLTALLDGWIAYSEGRTFPGGCFFYAVQAEFDARPGRVRDAIADYDRRWHDLVTRTAAAVTDDPAQLAFELVAYLELANLRSVLHDDPTAYTRARIAITRTLRESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC9</accession>
    <name>A0A7W7WZC9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase-like HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24909" checksum="92C986114EFD8559" modified="2021-06-02" version="1">MITPRALVLWDIDHTLLQSRGVGREMYERAMPEAFGLAFERLAEVSGRTEPDIISETLALHGVEPTVEHVDRLARALVAAYESGRGELAARGRVLPGAREALAALSREKSVHQGVLTGNLRAVARVKLAVFALDRYVDLETSAYGDDHRDRAELVDIARARAWARVGVDFGGLRTVLIGDTRRDVEAASAAGARVIGVASGNTGADELREAGADEVLADLRDPQALKGLLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZH6</accession>
    <name>A0A7W7WZH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="12939" checksum="2ADA151C2067B51A" modified="2021-06-02" version="1">MNIVLLVVSALVGAAFVAIGALGLRGLLHRNRFFGVRTKATLRDDETFALANRIAGVPTIVAGAVALVTAAAIAAKPETALVIGLVGLVGTLVIAGAGGVLGHRAAEAMPEPTPAGCGGCACAGGGCGVLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZT0</accession>
    <name>A0A7W7WZT0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="43528" checksum="6EFBF67A73CC2C34" modified="2021-06-02" version="1">MTPFDQHDPAFVADPYPTFAVLRSKGEVHWHEDMGIAVAVSHRACTAVLRHRSLGRIWTDVKPVERFTAFNLLHRNSLLENEPPTHTRLRRLVAAAFGRGHVERLRPWIASLADSLVDDLVAGIVERGEADLLSHVAGPLPVEVIAELLGVPADDRPMLQPWSNAIVKMYEYGLPPDLRDAAEQAAREFVAYLRELIAHRRTHPGEDLVSDLVAVTDTDGARLTEDELVATAVLLLMAGHEATVNVIGNGVTALLRHPAQWRRLAADPSLVTAAVEECIRYDSPLQLFERTATERVEIAGHVVEPGGKIAALLGAAARDPEVFDEPDTFDLTRTPNPHLGFGMGIHYCLGAPLARIEVEAALSALARKLPSAALATEPRRRAEFVIRGFASVPLTGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXI3</accession>
    <name>A0A7W7SXI3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020958">
        <property type="entry name" value="DUF3686"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12458">
        <property type="entry name" value="DUF3686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1602" mass="176977" checksum="E496DCAB50233A57" modified="2021-06-02" version="1">MTTELDAGTYEVLKARLADQAAGLAARAGELNTRRLEVFGSAELALLGTDRLRTANNCVPADAVHVGGLVLVGHQVLLGLKAEVAVADVFTLHRLVRADDAVRFEDVASDGVPGLLDDDRFRRDFAELHRYFRDARLIRLRRVEGRLLAVFRTGGVNGDVRVLRWQVDPDGTVSYVDNQGGRDHVFPRSHDFDWTPTTREQHVLGRHPHISIEDEVFVETVGGDLTVKVEDNTESGEGVYREPVDDPLQSLADADVHYARVGTLIVLRIRPYNESAWRHLVFNTRTKSVVRLDGIGLACRRLPEDQGLVFPGGYYLATGASKTFDTDVAELEFDREIRSANGEDVLYVFHDRDDRRMLLLPYNVIRKEIANPLPCGGYALYDDGTLVVFRASSEPTRVHPVQVWHTPYESDTYAAAQPTGTGPLERVGNADLVRGISDCLTVHRMVGEMAPSVPVFEDLIATCTRVDDTYHWLSDPDLGDLRTPLVEVRATATQVLDEFEAVRALTAQAADAVAETADKIAAFIRRTRAEVPSDADEWVRRLTELRATQGHLVTLRELRYVDLGRLDELAGAVEAEIDSTAHRAVEHLRHEDAFAGYYAHVDALAGRTGEIRTVAEAKPVYDELSAHQRGLEILTEVVGTLDIADATVRTTILERIGEVLGGLNRVRATADVRRRALLATEGRAEFAAEFALLGQAVTGALAVADSPQRCDEQLGRLLLQLENLESRFGEFDDFLGQLDAKRTDVYEAFASRKQALLDDRARRADRLVDSADRILASVARRVASLGSLDEVNAYFATDPMVLKVRSVAGELRGLGDQVRAEELDGRVLAARQEAGRALRDRLDLFDGETIRLGRHRFAVNTQPLDLTLVPADGGMAFAITGTDFRAPVRDPGFAATRPFWAQTIVSETDEVYRCEHLAAAILATHPLDALQAAGDKLLDLVRREADLRLDEGYERGVHDHDTTRILAELLRLYEAAGLLRHPASSRAAAQLLWAGADEDTRGLWTRRAISLGRARARFGPSRAFADLCAELGDLAGDPLAGEYLVEELCSTPFGFVTSAGARALVAEFHRALGSRVEFDADLAAVDATVRRELVQGWYEAFLGDRDEPDLPEAVVLELHPDLPRRHSDLSLESTVDGLLGTHPRVVDTRLAFRFDELLARTRAFRDHRVPGYRAYQRLRNDLVARERHRLRLDEYRPKVMSAFVRNRLLDEVYLPLVGDNLAKQLGAAGEGRRTDQMGLLLLISPPGYGKTTLMEYVANRLGLVFVKVDGPALGHGVTSVDPAEAPNATARQEVEKISFALESGNNVLLYLDDIQHTSPELLQKFISLCDAQRRMEGVWDGGTRTYDLRGKRFAVVMSGNPYTESGSVFRIPDMLANRADVWNLGDVLSGRDELFGLSYVENALTSNPVLAPLSTRDRGDVELLVRMAQGEPVRADRLSHPYQSVELEQVLAVLRKLLAVRDVVLANNREYIASAARADASRTEPPFRLQGSYRNMNRLAEKVVPVMNDAELAGVVDDHYRGEAQTLTSGAEANLLKFAELRGTLTADQELRWAEVKVAYLRERALGGAEDDPMSRAVGAVGLLADRIGGALDRLADRGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXX1</accession>
    <name>A0A7W7SXX1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoin utilization deacetylase AcuC-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="34"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="38080" checksum="04FE8986511A426B" modified="2021-06-02" version="1">MEMFWHDACLEHDTGTGLWELPGEWDWLDVPEPHPENAARLRTFRHALRIGPIAPHLAWRTGRLATPDELARVHTPAYLEELREACHRGERVALETNTVVGPGSWAAILAAAGTALSAYESSARLAYALVRPPGHHAQPGLPDGYCMVNNAALVAETARRDGRRVAVLDWDVHHGNGTQEIFRDTPEVLTVSVHMRHGPWGANHRQTGAPAESGPHNVNVELSLGAGDRAYERAFDEIALPAVAEFGADLLVCASGFDGSAFDPNGRHNLSGAGYRAIGRRVASLDLPTVLTQEGGYLRGYAALCLHSLIEGLLGLDLLADPLAYVPDDDGRTEADLDLVRAALKPYWSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYC9</accession>
    <name>A0A7W7SYC9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13358" checksum="90968887B9903AB0" modified="2021-06-02" version="1">MESSAVETGVTDSLLWKARFGEVVRGMVVDFAPRLFAVVQEYGDRVDGRVAAWGMAFPDHAEVVSVEGGLRMRLQDVDSALPVFATREGVSASVVWLPAFNTRLTEPVDVVDDVEEETAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH6</accession>
    <name>A0A7W7SYH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diguanylate cyclase (GGDEF)-like protein/PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="206"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="318"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="456"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="508"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="583"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="665"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="807"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117081" checksum="BB3FBA422F0FE4BF" modified="2021-06-02" version="1">MPKRVGRAPVVLDPARPPQDTAKDPAKDTVDLDGVRLPEGPAFLCDHKGVVMRANDAAVALALVGSAEVLVGRALGALLAGDPVDLRLRRADGTMLPVRVARYPVPGTGLQAVLLVDVSDLATAAEELRDEQRRLRAVQRVAQIGSWEYDPITGVTVWSESHYEMMGLRRDETTPGAQAVLDVVHPDDRDMVAGYWANRELDGHPIDIVYRIILPNGDLRWIRGVAEAKLRSDGRTQFITGYIRDITDQWRSDRALATERARLLEAQRIARIGSWTYEVVTGAVHRSDVLLELYAELGILPDEDLLCGVCEDDRPKVEDLRRRLLRAKDGSTVETEVRGVFGDRVYVCRARPEFEAGRLNRLHGTVQDVTEARAMERQLRDDRRRLADAQRAAQLGVWEWNVHTGAVVWSEMMSELFAVPADEPTSYATYLDLVHPDDRTWVDAQWQQLVVDRVPVQCEHRIVRRDGRVRIFRSYGVVVVGPDGKPLAVGTAQDITEQRAAETRMKRSSQRFADLVSMAPVGIGLFDEGERLVDANDALCDLLGMELEELRGMTSEQLTDPGDHADRAAMAARMTALGAGHTHKVPQRVLLRPDGVQVYCELHITLSVQDDGRRFWLIVFQDITERRRTAEALRHQATHDELTGLPNRALVKELLGTLLESPDRAKVGVLFCDIDNFKRVNDSLGHDAGDELLVALARRLEGGLPDGCTAARLSGDEYVIICENLDHVGGVDELATRVAGLLRTAVPVHGQLVRVSASIGAAVPNGSRVTGNDLLRFADAAMFEAKRAGAGRVSLASAALIASADRQVHLEGQLRDALASDGLALHYQPVVGADGSVYTAEALIRWPHPDRGLLPPDVFLPVAEQGDLMRELDRWVLRTALREAATWPEPGGRPVSVAVNLAGLVPGDPEFVDIVANTVAEAGIPWDRVVLELVETALVDLPSRVRHSMGELVSRGIRFAVDDFGTGYSSLARLKDLPAQIIKVDRRFVSGVGSDSSDFAVARAVVDLARAMGRKCVAEGVETATQFHVLRGMGVDAYQGWLFSRPVPPKEFRAVLALGPLHIPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYI0</accession>
    <name>A0A7W7SYI0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="278"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="528" mass="56822" checksum="E4571D1FB553056C" modified="2021-06-02" version="1">MTHEVTNQVPSLDGYDVADDPALLEALRRSDAAWAETELHELGLKAGSAHARLLARQADIHPPVLHTHDRYGHRIDEVEFHPAWHELMATAVGHGLHAAPWRDERPGAHVARAAKFYVWSQAEAGHGCPVSMTYAVVPALRTSPELARRYEPLLAAREYDFGTRAPEAKRGLLAGMSMTEKQGGSDVRANTTSAVPAGDHHVLTGHKWFTSAPMSDLFLALAYTQGGLSCFVVPRVLPDGSRNRMFLQRLKDKLGNRSNASAELEYDGAVGLLVGEEGRGVRTVIEMVNATRLDCVLGTAAGMRSGLVQATHHAVHRKAFGRALVDQPAMRNVLADLAVESEAATTVALWLAGTRSRLGLAVTKYWVCKRGPAHAAEALECLGGNGYVEDSGLPRLFRESPLMSIWEGSGNVAALDALRAMAREPEAVDEFLAEVDAGRGGDRRFDAAADAVKVALSDRDDLELRARVLVERMALLLQGSLLLRYGHPAVADAFCASRLGGEGGVAFGTLPRGVDFAAIVERGCPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV3</accession>
    <name>A0A7W7SYV3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">F4559_000251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="81" mass="9104" checksum="4802AE21A45FCC5B" modified="2021-06-02" version="1">MAAGTAASELRELTEEELVLRLREAKEELFNLRFQMATGQLDNNRRLRTVRHEIARIYTVMRERELGLSASPDGSTGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ7</accession>
    <name>A0A7W7SYZ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14195" checksum="08A7A6CE02FC36F1" modified="2021-06-02" version="1">MAGETLTTIIGNLTASPELRFTQGGTAVAHFTIASSTRTFDRQAGEWRDGDTLFLRCVCWNRLAENTAESLRRGSRVVAHGRLRQRSYEKDDEKRTVIEFEIDDIGLSLRYATANAQQTDSVPAEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC9</accession>
    <name>A0A7W7SZC9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6867" checksum="A07D77272168E2A2" modified="2021-06-02" version="1">MDSAAFFRRQAMLARRAEVMAANPTITEASALAPLMGDMQSEYWKWCLERHLIEPAAPEGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT5</accession>
    <name>A0A7W7SZT5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14201" checksum="5089E6061999471F" modified="2021-06-02" version="1">MTKRALVTGITGQDGSRLAGLSISRGHRAHGVVRRASTVDTSRIDHRNKRTPLRPSSPCTSAGTQRIARDHRRGYAVDGTPSDHGSPGSTIADCEVAAEVDRASVGLVVGHALGRGTVAPRRSSRQVTATALGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C8</accession>
    <name>A0A7W7T0C8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="543" mass="57011" checksum="13D9588E6BED6062" modified="2021-06-02" version="1">MAADLILTNATVHTVDPARPRATTLAVEGGRVLALDDVEAGPDTEVRDLGGAFVMPGLVDVHNHHALAGRAALFELTFGGDHGFEAILDAVRAWSRDLGPDEWVVGGAWASTLVETLSKESARRALDEAAGGRPVMLSDDSRHNRWVSSRALELAGVTAATPDPAGGVIVRDPATGEPTGVLLEAAGIQVERALQEKRKLTVDQHAAASRHAIATLHSYGITAFQDAGVSVDILGALKSLDEAGELAAWVVTSLLINDPIFGFDPIGSALIEAGARYRTEHHRPDFVKIFLDGVPPTHTAAFLEPYLPDEAHGACFHGAPTMAPDELEGWLRAAAAAGLSAKIHCTGDAAVRATLDAVGKLRAGGDTTTKVQIAHGQFVHPDDLARFGALGVAADISPFLWVPGVIPSAIANVLPAERAARMQPNRALLDSGALVAGGSDWPVSESPNAFEGIQGLVTRQDPTGAHPGALWPEQAITLAEAVEAFTLSGARAMGVDDVTGSLTPGKSADFVILDRDPFDSPVEALYTTEVVETWFAGRRVFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L0</accession>
    <name>A0A7W7T0L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17214" checksum="247E641E0F0010EB" modified="2021-06-02" version="1">MTNPRRDLRPTEVVRPVDPRDVHVDAHEEVVRRPVAHQEEVVERGDSRVRGVRVTCAVIDVVCWLFAIVLAVHVFLVVAGANPANGFAQLIDGWSAGVSLGLRDLFTPANDALRTLLNDGLAAVLWLLIGAGLTSLITRLALPAGERRVWYRRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T106</accession>
    <name>A0A7W7T106_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="375" mass="40822" checksum="8927E80AF16CFE2D" modified="2021-06-02" version="1">MPVEFLGIGGTNDGSETAPRTAGSFDKEYTLRLARAHEEHGWDRVLFAYGSGAPDPAQAAAYVATKLDRLQILLAHRPNVSYPTFAAKTFATLDQISDGRLTVHFITGGTDHEQQREGDYLTKDDRYSRTREYIGIVKKAWTSRTPFDHSGEHYRFADFVSDVFPVQQPRPGVSFGGSSPAAYRAGGAEADIFCLWGEPLADTAAQIESVRQAAREAGRTDVPRIQVAFRPILGATEELAWEKAHRIVGAIKERTAGGKALTRRHSLTKPENTGSQRLLEIAARGERHDRALWTPTAAATGGAGNSNALVGTPETVAAALLDYVDLGVDIISARGYDLLDDAIDFGRYVIPIVREEVAKRDRESRASVESIAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T180</accession>
    <name>A0A7W7T180_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanyl-specific ribonuclease Sa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030558042" evidence="1">
        <location>
            <begin position="28"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15776" checksum="DF205C0BBCD2402C" modified="2021-06-02" version="1">MTDRRNLLRMSALTGLVAVAVPGTATAAPSSTKPVGVWEVTLVIKEQQRPAEVSLWSLGADGLFLHTSDNGGTGFGRWERTGRSTFTARYREYVFSTSGVVEGQLRVSEECTFTGADRVDVASTADFHTPDGVLVGTFHAAGTGVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E8</accession>
    <name>A0A7W7T1E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase (TIGR01549 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="24076" checksum="C336AF47444F288F" modified="2021-06-02" version="1">MTRIEAVFFDVGEVLVDESREYGTWADWLGVPRHTFSAVFGAVIASGGDYRDTFRVFRPGFDLAAERERRAEAGQAETFAEENLYPDARPCLAALRDAGLLVGVAGNQTARAELVLRGLDLPIDVLGTSDGWGVEKPSVAFFERVVREAGVPASSILYVGDRLDNDIRPAQEVGVVTALLRRGPWGHILRVPEIEERCLFRLDGLAELPALVAGHNERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G4</accession>
    <name>A0A7W7T1G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="281" mass="28795" checksum="7000AF6E7F8B950A" modified="2021-06-02" version="1">MTDTPRTTRADLGGPAEPPAKPTKSRSRAKTPTTSEVTTRLGPTDPGRTSSEAETDRPAAEATARATPKAARRAAPAKPRPSTKAAAAKSSAAPARPDASTTAVPAAADPTGNPTTVTTTEDRASTTATATSSATAAAWVGWHLSDSALDDHREQFVRAYLRHRVGAKLGAFERGGRRYAVAKRWTTGLTVLLYTAAAAAGAVAVADPGRRALWGFLATVAAALATAVAAYEAAFSFRAQARRSASGAAVLNLLQAHGAPSGTGGVAAFRTEVESVLRHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1I4</accession>
    <name>A0A7W7T1I4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031184420" evidence="1">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="22822" checksum="6A2A2C84BF30D94D" modified="2021-06-02" version="1">MNKFARCLAVAVAGGVITLAGAGLAQAETSTTAANQDRVAAQVNRLDELSSLALTGVYIGDYDAANTAVGDLRLALDELEPNYADAVKADSLGAELQRILPALPGLPSLPSLPGVGSGVPDLGSLTNVLQGLLSTVSNLVSSLLGGLPLSNLPILGSLLGGVTGGGNPLSAVTGLLGGLTGGGSPLSAVTGLLGGLTGGGGSPLSGLLGAAGGLGGLTSLLGGGGLGNLTGILGGLTGGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1J1</accession>
    <name>A0A7W7T1J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.53" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20060" checksum="7C5959E933EFC6A1" modified="2021-06-02" version="1">MTVEYEEQDGVGVHDALQRLWTPHRLSYVRGEGKADGDEPAGCPFCRVVAVSPDEDTLILARGELVFAVLNLYPYNPGHLMVLPYRHVPDYTDLTPAETVEFAEFTQKAMRVIRSVSEPHGFNIGMNQGVVAGAGIAAHLHQHVVPRWGGDANFMPVIGHTKVLPQLLGETRRLLAAAWLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W5</accession>
    <name>A0A7W7T1W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative FMN-dependent luciferase-like monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023934">
        <property type="entry name" value="LLM_FMN-dep_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04036">
        <property type="entry name" value="LLM_CE1758_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="40503" checksum="33F75B10D91530F7" modified="2021-06-02" version="1">MQFGVFTVGDVTPDPTTGRTPTEAERIKAMVTIALKAEEVGLDVFATGEHHNPPFVPSSPTTMLGYIAARTERLILSTSTTLITTNDPVKIAEDYAMLQHLADGRVDLVLGRGNTGPVYPWFGFDIRDGISLAVEHYALLHRLWREDVVDWEGRHRTPLQGFTSTPRPLDAVPPFVWHGSIRSPEIAEQAAYYGDGFFANNIFWPKEHYQRLISLYRERFEHYGHGAAHQAFVGLGGQFFMRRNSQDAVREFRPYFDNAPVYGHGPSLEDFTAQTPLTVGSPREVVEKTLTFREHFGHYQRQLFLLDHAGLPLKTVLEQLDLLGEILPDLRRGFAEGRPADVPEAPTHASLLASATKETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y4</accession>
    <name>A0A7W7T1Y4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter (DMT)-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="30502" checksum="2A1A3982ECDC40D2" modified="2021-06-02" version="1">MTAQDNVTRSGRITAATLLGLLGITAFSLSLPSTRFAVDGLSPWFVAFGRAVGAGVLAAAYLAAVRAPRPTPAQWRRLAIVAFGVVIGFPLCTSIALTQATAAHGAIVIALLPAVTAVFGVLRGGERPSPRFWLSAGAGLAAVLVFIAVSGGAQGGFRSADLWFLAAVLVCGLAYAEGGVLARELGGARTICWALILSLPVTVPLSLVATDGLATAPAHAWWGFAYVTVISMFLGFFAWYAALARGGVARVAQVQALQPVLTLVWSAVLLDEHVDPLSVGVGLVVLACVVATQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T227</accession>
    <name>A0A7W7T227_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">F4559_001976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="204"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="32757" checksum="1F4843561069AB0A" modified="2021-06-02" version="1">MRLVFAGTPAVALPSLRAFLASDRHEVVAVVTRPDAQVGRGRKIERSPVAALADEHGIEVLTPRRAGDHDFLDRLRALEPDLCPVVAYGALLPEAALAIPVHGWVNLHFSLLPAWRGAAPVQAAVRHGDDITGATTFRIVKELDAGPVFGVVTEQVRPRDTSGELLDRLAESGARLLLSTVDGVADGTLRAIGQPEEGISYAPKVSVDDGRLDFALPAQSLDRVARAVTPDPGAWAEFRGERLKLGPVTPVDAPTLAPGELVVERKRVLVGTATGPVVLGDVQAQGKKRMPATDWARGVRIEAGERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T279</accession>
    <name>A0A7W7T279_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="45066" checksum="816B6F1BDDC8E126" modified="2021-06-02" version="1">MAARRTGLIRVRKAAGFTQESFAEAMHVDRSTVARWEQGAREPLPYQRPKLARLLKITMNELDELLHEEAGSVAVRQHAGSSLGDRLVDHNSSVAVETLPTPAQPVAMREVIGFRTVSEAFQAADRKIGGGVLYGQVVRFLQDEVAPRLLAPPSGATHYEVFSAAASFSEFAGWMAHDSGRDPQAKVHLTQAYHLAATAQNFQLGSNILASLAHLAVQMNDAQAAERLARKGISQMSGSQAHAPHLVARLHAMQARALALQGKELETRLALDAGESALDFVERDAQDSWLSGFDRASFAAEVALCMYDLRRYEDAARGAAQVIALRSGSDRVRSRTLAGLTLANALVALEDHAGAVRVGMEIIAAAPGLKSARVHSGLAQLQQRISEQADLPEVREMNDRLAASASAQIPTAQAEWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A6</accession>
    <name>A0A7W7T2A6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaconate CoA-transferase subunit B</fullName>
            <ecNumber evidence="1">2.8.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.12" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018730">
        <property type="term" value="F:glutaconate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="26065" checksum="F8B352561C1A8DAD" modified="2021-06-02" version="1">MTDPDEMMTVAAARALTGGQRVFVGIGLPSTAANLARRTHAPDLVLIYESGTLGSKPDRLPASIGDGILAETADAVIGVPEVFNYWLQPGRIDVGFLGAAQLDRFGNINTTVIGDYHAPKVRLPGAGGAPEIAASCGEVFVVVRQSRRSFVDRVDFVTSFGHGRGPGERARLGLRGAGPTRVITDLGVFRPDPATAELVLTDLHPGVSVDDVRAATGWDLRVVPEPGRTPPPTDDELAALRALKEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C6</accession>
    <name>A0A7W7T2C6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TENA_THI-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20735" checksum="57E63A953D03EEAF" modified="2021-06-02" version="1">METLRAFAAEEFHIVRSDWRAFLALAAQSNVQAQREFFSTVASGEGLALAKLRDFAAATGLSDDDLATYRPLPGCQSYPAYVAWLTLNGDPHDALLAILANFAEWGGYCAAIAKALREHYGFDAEGTAFFDFFAEPAPELDALGLRALDDVLATGWTPDRAIGYARLLHAYELSFWNTLAHSRESATPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M2</accession>
    <name>A0A7W7T2M2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YjbI with pentapeptide repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="407" mass="42361" checksum="A31111A6C3623E9E" modified="2021-06-02" version="1">MNGHPPRRRVPPRPSGPVARPAGLHRPRPRPRRPVNWTAVASLLAALAAVAGVVFTGLALRTSRAQNALTEQGQLTDRYGKAVDQLDRTGPEHLQGRLGAVYALERLARDSPRDHPTIVEVLSAFVRTTTPRPTRTGATTCPDQTVSPDVQAALTVLGRRDQSHDQTTRIDLRDTCLTGTDLTGANLVGTDLAGTDLTRGDLTGAKLRDAHLSNATLADADLGGADLTEVDLTGAHLADADLTRADLRTANLRGANLTRAQLTGADLRDGHLSGADLTEASLANADLTGANLTGARLADTDLTGADFHAADLGTADLTDADLADASLADANLGGANLTDADLRRVDLGAADLRKAILRGADLTGANLRSANLLGADLRGADLAGALHDEKTVVTGVLSDADTAGAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N2</accession>
    <name>A0A7W7T2N2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MGT family glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="41475" checksum="9B66D78184C77A52" modified="2021-06-02" version="1">MAHFAFVSAPAAGHVNPTLPLVEELVRRGHRVSYATGPATADGTARAGATPVVLPSELPPDMDSLGGFTPEDLAITLEHFVGDAEASFPVLAEHFEADRPDVVCYDSVTFTGRMLANLLGVPEVALVPTFAENERFSATSVYLPPTFDHGHPRLVAAIGRMAEFAAGHTFLENPNLMFGHVAPTSVVFLPRSFQLAADTFDSRFHFVGPSLGSWQDAEEWTPASDDPVLLISLGTVFNARPEFYRTCVEAFADTGWEVVMSVGSLDPGTLGPLPATVSVHTRVPQVAVLRHASVFLSHAGMNSVLESLWHGVPLVTVPQIPEQRAVAARTAELGLGVVVDRPTPEALRAAVASATVLRPAAEAVGETLRSRPGAPVAADVLTGLLTRETTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y2</accession>
    <name>A0A7W7T2Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GTP pyrophosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="1">
        <location>
            <begin position="49"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="23848" checksum="47A63F483022907E" modified="2021-06-02" version="1">METGVADDLLRRSLVVYKFAVEELMTKLRILSEEFDLVHRHDPIEHITQRVKRPDAILDKLRRKGLEPDLALAAEHLDDVAGVRVVCPFVSDVYRVRDMLARQSDVEILLTKDYIAAPKPNGYRSLHLIVRIPVFLSDRVEHVKVEVQLRTIAMDFWATLEHKLYYKYDDHVPAGFVEELTTTAAIAAELDERMESLHLKVHRDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T315</accession>
    <name>A0A7W7T315_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
            <ecNumber evidence="7">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031490293" evidence="5">
        <location>
            <begin position="29"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="37"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="47984" checksum="DCF8D03A1A4C3E8C" modified="2021-06-02" version="1">MSKQRWGAAVLAGALAIGLSVAASPAQAHDRRGGDPVRTVGYYTQWGLKDRGIPVRYLVDNGTAARLTHLNYAFGLLDEQGRCVSSDPVADYQRLIPAEQSVNGRADQPGQALAGNLNQLKQLKKKFPELRVYISLGGWTGSKYFSNAALTPRSRAEHVKSCVDLWLKGNLPGTPAGAAKGVFDGIDLDWEWPATEGNAGNVVRPEDKQNFTKLLREYRTQLRQQGFKDRKTYDLTAFLPANREAMDRGYELADVYKLLTFATVQGYDYHGTWEKTTNQQSALRVPEGDPTTPKDSGEIVVDAHIERGAPLDKITLGVPYYGRGWTGVPDRNNGLFQQSTGAAPGSYEAGYEDYRTLKTLVAGGKFKLYRDDKAGHAWLFDGTTFWTYDDPTELARKGRFIRDRKLGGAMIWSLDGDTSQGELIRGLSSGLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T345</accession>
    <name>A0A7W7T345_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031507587" evidence="1">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25223" checksum="C17DD461B26666BA" modified="2021-06-02" version="1">MRRSIIVSAVVVTALAFAPPAYADNRDSLRWAGYTSDVDEGSFDRISARWFVPRIECADGEDGTEVAQWIGLDGVGDDFVEQVGTTSECAGDSRGRPKYFAWVESFPEPAKRLFQVRPGDEIRAWVDLDGGRFRYEVHDVTLERLAGGKLATHGPGRSAEAVVEAPPGARLPDFDTARFRDVLVDGDPIGDLDPDRVTLVRAGEPRVVRAKPTALSDDGRDFDVRFRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T382</accession>
    <name>A0A7W7T382_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="384" mass="42660" checksum="9D0A57D44319D218" modified="2021-06-02" version="1">MWLPPVEEIVAAFLRLEVPRVPFRFVQFSRNEQRAMPTLVSYWEATGIEVPEPLALETRYERERQLAYGAVLDRITTVDPAAVPMKGPMICRLYPAGLVRETADLDVLCSSVDTLWAVADDLMGLGWTLNSVSVNGIDGQAHPSVQLARPAAHPRLTNKDRVELTTVCYRGDGYRTPPRLRTLSGPPTIEDCFTWFVDEIADRDFRMRDMVDLAVFDHHFGTGEVDLVLIGHHLVDYGLRTAFARLAAEAAKRYPAATPMLTRVRAAMPRRATTKRLRAPRTSGLLAGSVAIANYTIRETNRPAVLARCERWLAGLQERFGARKLFERGVPLHGVEVSDERSAGTGIEFRGAGALLRSPVGTYALAAGPVVRSTWVEPFELVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V9</accession>
    <name>A0A7W7T3V9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="36166" checksum="A4FB6A49488C3FC0" modified="2021-06-02" version="1">MKAMVFRGPNRRSWEDVPDPVVVAPTDAVVRVTAATICGTDLHILNGDVPEVEPGRVLGHEAVGVVESVGAAVTSIKPGDRVLVSCISGCGRCEYCRTGASGQCRGGGGWLLGHLVDGTHAEYVRVPFADFSTHRLPDEVTDGDAVMLSDILPTAYEVGVLNGRVRPGQAVVVVGAGPIGLAAIETARLFSPGLIVAVDLAKPRLEAAKRFGADVTVHADEDVDDLVADLTGGLGADLAIEAVGVPETFELCARLIRPGGRVANVGVHGGPVTLHLERLWIRNATITTGLVDTYSTPMLLRMLAAGRLEATGFATHHFALDEMALAYDTFARSAETGALKVVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M7</accession>
    <name>A0A7W7T4M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10636" checksum="70A17E68C7BD799A" modified="2021-06-02" version="1">MGHGAATARFVNRTTATTTVWLRPLTERALPSARLIDIVDGAPVTDMYDVGPGADVLLELRLIRPAKARLAVTVRLPVSWGRPGGQVGPSVAFLLPAPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N6</accession>
    <name>A0A7W7T4N6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <ecNumber evidence="5">4.1.1.112</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Regulator of ribonuclease activity homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">RraA-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_002609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + oxaloacetate = CO2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="SSF89562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="11">
        <location>
            <begin position="12"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4965250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="465" mass="50558" checksum="5B188E0541198EC2" modified="2021-06-02" version="1">MSHPLGLRPSKIIAVHLNFRSRAAERGRFPDEPSYFVKPPSSLAWSDTELVRPKGTELSAFEGEIAIIIGRFAKNVSRADAWEYIAGVAPANDFGVHDLRYADRGSNLRSKGSDGYTPIGRVLDPADLDLKNLRLRTWVNGEVVQDDNTSDLLFDFAYLIADLSRTITLEPGDIILTGTPTGATTCQPGDVVEVGIDDHERLRNVIVESDDELPKPGAQPKVTQVDKDAAVGGAVPAIKPETEKMLREVCTATIYSQLRKRGIHHTFFTGLKPARTDLKMVGVAHTLRFLPLREDQFAERGNGMNAQKRAVESIGPGQILVIDARDDHGAGTLGDILAARLIKRGAAGVVSDGCFRDSPMFADLELPSYSAGAHAAVLGRKHVPWEVGVDIACAGVLVRPGDILVGDAEGVILIPPALVDEVARDSVQQEHEEKFILERVEAGESIDGLYPLGKAKRAEYEEWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W8</accession>
    <name>A0A7W7T4W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="203"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="442" mass="47571" checksum="79E96235EAA28C4F" modified="2021-06-02" version="1">MSNVEDAGLRTAQDEVVGLASELIRIDTTNTGDPDTVVGERAAAEWVAGKLAEVGYETTYVESGAKGRGNVVARLAGADPSRGALLVHGHLDVVPADASEWSVHPFSGTVQDGYVWGRGAVDMKDMVAMTLAIARRFKRDGIVPPRDIVFAFLADEEAGGKYGAQWLVEHRPELFEGVTEAISEVGGFSVTLKDDVRAYLVETAEKGIRWLKLRVRGTAGHGSMIHRDNAVAKLAAAVTKLGQHRFPLIVHPSVREFLDGVTEITGIDFPEDDIEGAVGKLGALSRMIGATLRDTANPTMLQAGYKANVIPSVAEATVDCRILPGREESFDRELAELLGPDVEREWVGLPPVETTFDGALVDAMTASLIAEDPGARVLPYMLSGGTDAKSFQRLGIRNFGFAPLKLPADLDFSGLFHGVDERVPVDALQFGVRVLDRFLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y5</accession>
    <name>A0A7W7T4Y5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17781" checksum="79C667FA00E4AB1A" modified="2021-06-02" version="1">MDLTPFVDNLRNHLAATADAAGEESRAVTERITSTLESALRLMLLDALSAAAEEITRDLAPGSVDVRLRGRELGFHVDLPPRPEAEPVPAAPEPVDDDGTTTTRINLRLSEQLKARIEEAASRERMSVNAWIVRAAATTLAAGERARVDQRSGDRGRFTGWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E3</accession>
    <name>A0A7W7T5E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33775" checksum="B5AB22ACFB143D47" modified="2021-06-02" version="1">MVPARSLPTPAHRHGRRRGIPTRHRSRPLRVQHRPARRPRPGRPGDRNHHRRQRKVRGHRASGPGRTPSAPTPTGEHPARSDPRSPATANAATTADPTEAAPSPPSTPASWNRRMHSPRCPRLPGTTAVSPRPNVAGTGFWSCYRKIQPVSGAPVTSRSTSATSPSTPWTDSFPGGPTADSSTRSAPDSTPPRHGRRLPCRSTEILDYPALGQPQTSSANNSTASREPQPTTRTRDTTRNTGQPGTARSSEPRKPPPGTDHHPVPRPMGSSAPPGDSNRPGRFPHPTSHNHRATGIAPERRTGGIPWSLRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G2</accession>
    <name>A0A7W7T5G2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="652" mass="69350" checksum="541E9662518C1CFC" modified="2021-06-02" version="1">MVEKVENRRFVAVFGPSGTGKSSLLRAGLIPKSTAGGTNRVLLVTSGADPIRECAIHLSVPLGTTAGAVKAELDADPTNLDLLLRQSLVGAAANAEILVVVDQFEELFTQCGDRAARTRFLSALTGATEAPGSRCRVVLGVRADFYSHCLLEPGLAGMTTDAQVAMRSMTAEELRRVIVHPARHARCVIENALLTTLVAEAHGGIGTLPLLSHALLETWRRRQGNTLTLAAFHRAGGIDGALAATAEAVYATMTPRQQQLTRSLLPRLVVLGDATEDTERRTRRSELDDDEDTTAVLSILAEARLPVLPADSVEITHEALLDAWPRLRDWLDEDHDGQRLLRGLTESAAIWADHGEDPDTLLGGTRLEVAREWARDRHDLSSAESRYLAAGIAADKRDRQSKRRRRRSLRALLALVSILAVTAAGTAFHADTVRKASARERDIAAALGVADEITASIVDDPPLAAARGLDAYRLSPSPTTGDLLLAAAGTASGARLADGECGCMITMAPRRDLVATTHRRTGLTTLSLLSGQGTTDTASFTGGVGSGVFSPDGRTLVTHDAEARAHLWDVTDPSRPVRRATLDGRFGNSVFAADSTTLFTQGSGCRPSREPSSSGMRRRNRTGRPEAPGGCGTSANHPGHGTWPNCPPGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I6</accession>
    <name>A0A7W7T5I6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21098" checksum="3CF88C803B9E789B" modified="2021-06-02" version="1">MTPRRTAAVREDLITSAQRLISTRGTAGLTVRDIAREAGVAAGALYNHFSDKEELLALALHAHVSAVDRSHGSPTLDGTLAENLKALVTHALAVHIVMLPAFVGLVGSPEVMARFDALPNPLVAGLGLRAAVVGYLERERARGEVAVGVDLEIVATLLIGACHELVMPHLYRNAPLPESVDPSFVDRLVSTVLDGIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5X7</accession>
    <name>A0A7W7T5X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA carboxylase carboxyltransferase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="29"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="538" mass="56915" checksum="04BE00E398FD055C" modified="2021-06-02" version="1">MTSTADLSGTLRSALDPTAADFAANRAALLARIAEIDRAHAEALAGGGPEYVARHHARGKLLARERIELLVDEGAPFLELSPLAAWGTAYPVGASVVTGIAVVEGVDCVVVAHDPTVRGGASNPWSLRKTLRADDIALANRLPLIALVESGGADLADQGEIFVPGGRAFRDLTRLSAAGVPTIAAVFGNATAGGAYVPGLSDYVVMVEDRAKVFLGGPPLVRMATGERADDESLGGARMHGTTSGLADFVARDEVDAIRSVRRVVARLGRRRLGAEPGPVDEPRYDAEELLGLVPADARVPFDPREVLARIVDGSRFDEFKPDYGTSLVTGWADLYGYPVGVLANARGVLFSAEAQKAAQFIQLANRADVPLLFFQNTTGYMVGTRYEQAGIVKHGALMINAVANSQVPHLTVVLGASYGAGNYGMCGRAFEPRFLFSWPNARSAVMGPDQLAGVLSIVARQAAAAKGREYDEERDAGLRHEVSTRVVRESVAEFLSGRLYDDGVIDPRDTRAVLGTCLAAVHSGPVRGADGYGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T731</accession>
    <name>A0A7W7T731_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019952">
        <property type="entry name" value="F420_OxRdatse_Rv1855c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03560">
        <property type="entry name" value="F420_Rv1855c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33896" checksum="FA344ADCBA195746" modified="2021-06-02" version="1">MELELRVFTEPQQGATYDDLLAVARTAEAAGYGAFFRSDHYLRMGSADGLPGPTDAWITLAGLARETSTIRLGTLVTAATFRHPGPLAIGVAQVDHMSGGRVDFGLGSGWFAEEHAAYGLDFPDIGERFDRYEEQLEIITSLWATPVGETYSFEGKHYTLKDSPALPKPVQARVPVVIGGGGKKRTPALAARYATEFNLPFVPADFAVEQFGRVDEACRAIGRDPGTVTRSVALVVAVGKDDAEVKRRADAIGREVDELKANGLAGTPAEVVDRLGEWRERTGAHRYYLQVLDLSDLAHLELVAAEVAPQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T736</accession>
    <name>A0A7W7T736_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="27275" checksum="589A76B119B005C5" modified="2021-06-02" version="1">MGDGVRVTVGEWVDADLGDVLAAVDSLVALGDHERAAVLLAAVWTALPGDVDEIWAVRLRDRGAVLDRTPALARVFRLGAEYFLDRGAHRAAEAEGMREWEVWHELGDHEGQVAALGWLETLFRARDRLDRVIDCGDRLLGLHLRAHDEKGAAAALGHLGALMLEAGRPDAAVDYAIRADKAYERLPDASAADRAVVWETWGRALWATGAEAAARRQFDRAVVGYSGVDDQAAHRVRALGATPPGSPLGPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T748</accession>
    <name>A0A7W7T748_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="86" mass="10031" checksum="89DDA078FB7F1198" modified="2021-06-02" version="1">MTNPSRRGRFLITNAHFDGPRWKEQKDKVAALAHGYDNTTQQWHYWFDLDQPPVDTINTLFRLARVYGTTVNFSIHEAEPRPETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T766</accession>
    <name>A0A7W7T766_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="24396" checksum="62C1A663D23C6565" modified="2021-06-02" version="1">MSPTLSQLLDDAALLSFEHQLRLSEVLGRHSWGADLQAGRFEFTGDHPLVCTASHLLGTAAPGPGSWLWSWANPAGYGPAVTGLAASVRDFGARHGIAQLAEAEVPFSALPGVTDAVGAAGVLVEAAKAVSGRFTSYTADAGGGTRIAVLIEHPDLALPAPEPARVMRVLQQGVAELPLTDHRRAVYAYGVRRGLRVEFGPDHRNLVVTGPGLSATVDFDPAGRVSGISASLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H2</accession>
    <name>A0A7W7T7H2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="15"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27733" checksum="83184F73CD592ADC" modified="2021-06-02" version="1">MTTFAVRRDGASPVTQVLVLTQRSLRALVGDPRMVVFSILQPLVMLVLFSQIFANMANSPGFPAGVSYIDFLMPAILVNTAMQAALQQGVGLVTDMKNGVLARFRSLPVRPGAVLVARSLSDLVRTAAQLALMVVLALAVFGFRPAGGVVGVLAAFGLALAVGWGLGWVFLAVAAWLRNAELMQTVGFLAMFPLMFASSAYVPINTLPGWLQAVANVNPLTHAVDAARTLALGQPVTGAVAALTGAAALALGGWLLAVRGFRRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L6</accession>
    <name>A0A7W7T7L6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031501053" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5178" checksum="977D5ECC0D54012E" modified="2021-06-02" version="1">MSSLSPLRRLMAVLSVCAAFGVLVTVPASAVTHTRSTQSEGYTPPYVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7M4</accession>
    <name>A0A7W7T7M4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031184573" evidence="1">
        <location>
            <begin position="30"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="78"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="221"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="32452" checksum="628E0FA990442C4D" modified="2021-06-02" version="1">MIRTARRLGTALLASAFAVGFTPAPTASAVPAAPATLVARHSGQCLGIVPGSPPPVLWAAQGPCAGTSNQLWSEAAQASGSVVLVSALNGQCLEVDHAGLADGVPVNPAPCDGGTHQRWRKVTLTAGFVRYVAEHSGKCLTVDGAGQAPGTRAVQWRCDSGYHHQQWNLAPGRPAAPGEIVVLHSGQCLTAEPADTRPSPWISQRPCTGGGDQQWSVVERSPGVVAIVSRRNGTCAEVDGAALQDGARTALRQCGGYSHQSWRRTVLPGGYSQLLALHSGRCMSVKDADVIPGAWVVQAECGRAAHQLWFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N6</accession>
    <name>A0A7W7T7N6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="15" type="ORF">F4559_004886</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026389">
        <property type="entry name" value="SecA_Actinobact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04221">
        <property type="entry name" value="SecA2_Mycobac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="92"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="422"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4967527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="772" mass="85676" checksum="AC80B86C490B9877" modified="2021-06-02" version="1">MTTLLGRFKQRLRRFAQKPGSADLAPYRKLLVDVNELADRFSGLDDEELTAAAAELREKSDFGRVELVEVCALAREAADRALGLRPFDVQILGALGLLEGHVVEMATGEGKTLSGAIAAAGFALRGDQVHVVSVNDYLAQRDAEWMKPLYDLLGVSVGWIGQTSKPEERRAGYAAEVTYAPVSEIGFDVLRDRLATDEADRIVPEPRVALVDEADSVLVDEARVPLVLAGSTAGPSADPALAALVKRLRRDLHFEIDDEERNVYLTGAGSELVERELGGIDLYSDEHVSTTLSKVNVALHAQVLLHRDVDYIVRDGKVHLINDTRGRIANLQRWPDGLQAAVEAKESVQTTDSGEVLDSVTVQALLSRYPTVCGMTGTAVAVAEQLRDFYSLEVLVIPPNVECVREDEDARLYTTLELKEAAIVEEIKEVHESGRPILVGTLDVAESERLSRKLSEAGLECVVLNAKNDAEEAAIIADAGSFGRVTVSTQMAGRGTDIRLGGHDQTDRERIAELGGLYVIGTGRHPFSRLDDQLRGRAGRQGDPGGSVFFSSLQDELVTQYVPDHDEPAEVEDDGRILDLGTLHTVDHAQRVAEGVQLEIHRNTWRYSKLVEHQRTLLLEFRDRVLTSDLAWKELAERKPERAEELDELDEEIRVRAARLIALHHLDQRWTDHLVFLTDLREGIHLRALARQNPLDEFHREAIPQYHRIAPDAWEEAEETFVKAKIDEDGAHLAEAGVKRPNTTWTYLVNDNPFSSGLEETFKSLVKLVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T2</accession>
    <name>A0A7W7T7T2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010038">
        <property type="entry name" value="MoaD_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01687">
        <property type="entry name" value="moaD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9372" checksum="DD2A72835FD84F21" modified="2021-06-02" version="1">MAITVSIPTILRTHTGGQKSVEASGATLEQVIDDLETNHGGLKARLVKDGSLHRFVNVYVNDEDVRFAGGLGAEVKDGDTVTILPAVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T5</accession>
    <name>A0A7W7T7T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="12728" checksum="EB619BBF03C860C0" modified="2021-06-02" version="1">MPSSQGRSVDYGVTELEVELGGAGKVACVVTSGADCGGQTHADQALDVDMAAQATHQAGDLGAQRALVGVHLIQDQVPQRTVPEQLAVVAPGKQVLEHGVVGQQDVRRSILHRVPHVCGVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B7</accession>
    <name>A0A7W7T8B7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031396537" evidence="1">
        <location>
            <begin position="22"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="413" mass="45562" checksum="719035C045F2EA9E" modified="2021-06-02" version="1">MKRRAVAAVVLLATAACTAAATEEDAAPPPSVVEVYKRWPNGPNPTGDPAVFPINVWMQDPSALEGGVKLGDAYPEIGIDFGIGLWEDQWWYLRRDGLVQTDWRAYPDPKRVDEVLADKEHQRNYVGYLVVDEPDMNVAYGDQFHADMWPSAVLKKSNEVRAKDPSRPAFINFGVWMGTPGGGVGYGYIEKSYEEDMRTYCQAADIASADYYGWTHPDRNERVGAYTYGEVLDTMRKWCGPDKPLWGFVETGHPHDKGELITPDQLESAVWNTILHGATGINYFAHSFYTDGKGEYSSVLTRPEIKERVKAVNARLKALAPVLNAASVPGVSAKSRNDVPVSVLHKKASGARWVIAQTDGNATLPRSGKATVEITVPVSSGTATVVDENRTVPIVDGRIVDDFGPYQVHVYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C1</accession>
    <name>A0A7W7T8C1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbcD</name>
        <name evidence="10" type="ORF">F4559_005817</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SbcD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="9">
        <location>
            <begin position="266"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="40900" checksum="E21FE1BAF4AEF8C9" modified="2021-06-02" version="1">MRFLHTSDWHVGRTFHGRDLLAEQESVLSGLADLVDSERVDVVVVAGDLFDRAVPNAEAVAVCSRVLERLRAAGATVVVTPGNHDSAARLGLFGGFTAAGGLHVRTRAAAVGEPVLLADDHGPVAVYGIPYLEPETARQALEVPDARGHRGVLTEAMRRVRADLATRSARSVVLAHAFVTGGQACESERTIAVGGVQDVPASVFDGVDYVALGHLHGQQTLAEGMRYSGSPMAYSFSEARHGKSVWLVELDAGGLAGVERRPLPVPRALSTVSGGLAELLSAPEHDEIADHFLSVVLTDRVRPLDALRRLQARFPHAVHVDWQPEGGRSAELRFAERVRGRSDEEIACCFLEDVRDERPSERELAMLREAFAAAAREEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K3</accession>
    <name>A0A7W7T8K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">16S rRNA (Cytidine1402-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.198</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="23300" checksum="473DC6E8F5E9624A" modified="2021-06-02" version="1">MVSFYDQVELSRLPGLLEAMRTGSTVVLVTDAGMPSVSDPGYRLAAACADEGIPVTCAPGPSAVTTALAVSGLPSDRFCFEGFPPRKGGERQRWFAALVREPRTTVFFESPHRLAATLADAVTVLGGDRRAAVCRELTKTYEEVRRGTLAELAAWAEAGARGEITVVLAGADPEPAPALEDLVAEVKRRVAEGERLKVAAAEVAERSGVGKKALYDAVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X2</accession>
    <name>A0A7W7T8X2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6230" checksum="98C462F721E4FFB2" modified="2021-06-02" version="1">MTTSKALPTAVALFTLGVAAIVAMFVAGADGLPAWVFAAGWLLAPAGLAVGVFSAVRGSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T911</accession>
    <name>A0A7W7T911_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N,N'-diacetylchitobiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="35718" checksum="0867DCB7B89845F8" modified="2021-06-02" version="1">MNTTDSAVPARGSSPAPRRAVKGGARRRQGSALDRALPYLLLAPAVIAILWLIGWPVLSVVITSFRKLNLKELTRGEVVWTGLDNYTLILSEPTFWTIALRTVLFTAAVVFVSVGAGLAIALLMRQVSPVVRVVLQVAMLLAWAMPLLAATTVYQWIFDQQYGILNKTLVKIGLSGFEGYSWFTSGVSTMSVIGLLIVWQAIPFLAFSLYAGVIGIPRDQYEAAGIDGASAWQTFRAVTWPELRPLLLMVTFLSLLWDFKVFTQIWAFKKGGPDGGSTTLPVLQYLEGLAKSHFGVAAAVSVLMVALLALLTFQYLRRLIRQEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T928</accession>
    <name>A0A7W7T928_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="28"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="342" mass="37022" checksum="1131CE2E1F4B6A9B" modified="2021-06-02" version="1">MAYRPDQSRYDRMSYRRVGRSGLKLPAISLGLWHNFGDDRPFETGRAIVRRAFDLGITHFDLANNYGPPYGSAERNFGRLLAGDLAPYRDELVVSTKAGYDMWPGPYGEWGSRKYLLASLDQSLGRLGLDYVDIFYSHRFDPDTPLEETVGALVSAVRQGKALYVGISSYSATKTREAAVLLRAEGVPLLIHQPSYSLLNRWVEAELLDALGELGTGCIAFSPLGQGMLTDKYLDGVPADSRAAQGKSLSTGLLGEENIGRVRALNAIAAARGQSLAQLALSWVLRDPRVTSALIGASSVAQLEANVAALDGPPLTHDELAAIDEHAVESGIDLWARSSQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C0</accession>
    <name>A0A7W7T9C0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <shortName evidence="5">AcCoA synthetase</shortName>
            <shortName evidence="5">Acs</shortName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetate--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acyl-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acsA</name>
        <name evidence="9" type="ORF">F4559_006298</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01123">
        <property type="entry name" value="Ac_CoA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="8">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="6">
        <location>
            <begin position="92"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="7">
        <location>
            <begin position="536"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="5">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="390"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="414"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="658" mass="71873" checksum="8288363D0A3ABEB9" modified="2021-06-02" version="1">MTQPPAALDNLLTENRTFPPSDEFAAQANATAALYEEANADREAFWAKQAERLSWDTKWTQVLDWSDAPFAKWFVGGKLNVAYNCVDRHVESGHGDQVAIHWEGEPGDSRAITYAELQREVSRTANALAGLGVGAEDRVAIYMPMIPEAIFSMLACARLGALHSVVFGGFSAEALRTRIEDSQAKLVITTDGQYRRGKPAALKPAVDEAVAAAKSVEHVLVVKRTDTEVEWTEGRDIWWNDLVPQQSDQHTPEAFDSEHPLFILYTSGTTGNPKGILHTSGGYLTQASYTHYNVFDLKPDTDVYWCTADIGWVTGHSYIVYGPLSNRVTQVVYEGTPNTPHEGRHWEIVQKYGVSIYYTAPTLIRTFMKWGADIPAKYDLSTLRVLGSVGEPINPEAWIWYRENVGGGKAPIVDTWWQTETGSIMISPLPGATSTKPGSAQRPLPGIGAKVVDDQGNEVPHGGGGYLVLDQPWPGMLRGIWGDEQRYRDTYWSRFGDLGYYFAGDGAKYDADGDIWLLGRVDDVMNVSGHRISTTEVESALVSHPTVAEAAVVGASDPTTGQGIVAFVILRGGVAEGSDGADAIKALRDHVAKEIGPIAKPRQILVVPELPKTRSGKIMRRLLRDVAENRQVGDVTTLADSSVMTLISQGLNSGSSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G5</accession>
    <name>A0A7W7T9G5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysS</name>
        <name evidence="14" type="ORF">F4559_006205</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="263"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="50492" checksum="EE32983663A7437E" modified="2021-06-02" version="1">MSLHLHDTATRSLREFVPHVSGTASIYVCGATVQGVPHIGHVRSGLNFDVLRRWLMRTYDDVRLVRNVTDIDDKILAKAADAGRPWWEWASTHERAFADAYTALGCLPPSYEPRATGHVTQMVELMRRLIDLGHAYAADGDVYFSVSSFPAYGALSGQRVDEVHQGESAATGKRDPRDFTLWKAAKPGEPAWPTPWGPGRPGWHLECSAMATEYLGGTFDIHGGGIDLIFPHHENEQAQSRAAGDGFANYWMHNAWVTMSGEKMSKSLGNVVSIPEMLTRVRAPELRYYLIGPHYRSTIEYSEAALEDSVSAYRRIESFLRRVVERTGAVGEGDLAEAFVAALDDDLGTPGALAAIHRRVREGNSALESGDDLGARTAAESVRAMAGVLGLDPLCWTDGTASDGGGRKALAVLVEQLLDQRRQARQEKDFARADALRDRLLAAGIAVEDTPDGPLWTLKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J2</accession>
    <name>A0A7W7T9J2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="19681" checksum="07F68EB80D17729F" modified="2021-06-02" version="1">MNLYRQGSQEPQEIQDDLKLDEEVNKQYLEVIITFTIKNWGREPVTYSLGSPWENTGSYILYPDAPQRLWWKYRTSVDHWMRISTGEASIYRSEERPDGPTNLITLWVPVDNLDSTVNDMHKWDSYIMPITVNRLSVVAHPGTRISTTARKITHFKREWIPLREENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J7</accession>
    <name>A0A7W7T9J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11644" checksum="6AD3238756D27D72" modified="2021-06-02" version="1">MSEHPLVARLLAAGFSVHPQLDRHGYDTGLLFVRRSPRGFEVLSAWDDDYALATSLPESRDWSNPFASSGTETTGETTFAAAVEFLLSAKHAAVEGDWFDGGSDVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9L6</accession>
    <name>A0A7W7T9L6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15144" checksum="380E240CE508A33B" modified="2021-06-02" version="1">MSSSNDALRALNDHGFQYVIGPGYTSNGKEIPFTLLYVRAWGEAPFIDLVHLRAEDDATALRVASNGPNPNLFARDNIVWSSRDGGDLVEVVTDLLAVPKPGEPHAPTLQVREPSRMWLPEQSKSNGEIISYPNTINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9M0</accession>
    <name>A0A7W7T9M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="16720" checksum="DD59BE5929E226B3" modified="2021-06-02" version="1">MDTRASGAAQPQWTRVNGLTSFTETTDDNTEDDGDFDSDGWGSTVVTQRTWSIEAEGKRKRADAQTFTPDPGQEAIRKAGRVVGFAANIRVRWYRRDGSPDAYEGTATVSGFTKGGAVTDLEPFNFTLNGQGAPVEITNPANGTGGAGLAAAESVKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y1</accession>
    <name>A0A7W7T9Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthetase component 2</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22770" checksum="C9BB1A81CB9ECDC6" modified="2021-06-02" version="1">MRVLVVDNYDSFVYNLVQYLAQLGVESVVWRNDEVPLGEVRQFGGVLISPGPGTPERAGRSMDVIRECADSGVPVFGVCLGHQAIGAVWGGTVDLAPELLHGKTSVVHHRGGGVLAGVPDPFTATRYHSLAVVPETIPEEFEVTGTTESGVVMAMRHRSLPVEGVQFHPESVLTDSGHRMLANWLRVCGFEVAEDVVASLESGMRRLAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA22</accession>
    <name>A0A7W7TA22_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="27570" checksum="0BC64346CB85639F" modified="2021-06-02" version="1">MTDATRRERLRAETERDIRRQARALLAAQGRDAVTLRAIARELGITAPALYRYYDSREDLLARLCDDICVDLDGELSKALEPVVSEDITVHVFTVCKAFRRWALDHPNEFALVFASTDNRRADMLAGGRTDDQFGRVFLEVAAKLVASHPFRKPVPPDVPETLRNDLTAFQKVLINTVVERGVVVDETVLHLGAIYHILQSWVRLYGHVALEVFGAFPFAVSNPEPLFELMLTNLMGEMGVDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA31</accession>
    <name>A0A7W7TA31_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="34989" checksum="AD4B9610F3543985" modified="2021-06-02" version="1">MSDVRNLIVVGSGPAGYTAGVYAARAQLEPLVFEGSQYGGALMTTTEVENYPGFRDGIMGPDLMEQMREQAKRFGAELRAEDVDKLELEGDVKYVTANGVRYAARAVVLAMGAAARYLNVPGEQRLLGHGVSACATCDGFFFRDQDIAVVGGGDSAMEEATFLTRFARSVTIIHRREEFRASKIMLERARANEKIHWLLNVEVTEVLGEDSVSGIKVRDTRTGEESEHAFTGFFLAIGHDPRSELVRGQVDVDDEGYVRVVGRTTYTNLDGVFAAGDLVDHTYRQAITASGSGCSAAIDAERWLAEHDASEAEHVGAEPVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA88</accession>
    <name>A0A7W7TA88_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20416" checksum="97575A321F1E5040" modified="2021-06-02" version="1">MPPDAARRSERSRLAVLEAALELVVAVGYGRLTVEAVASRAGVGKQTIYRWWESKGALLFDAFVELGPVAVVGGVRRGEVVDDLTDELLAAVAEVCERRFDQVCRALVHEGRTDLVMLLLAPRRVAVEERLAVARRLGEVRRDLDLGMAVELLLGPLYQRWLLRTAPLTPDFVETLVDVALGAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF1</accession>
    <name>A0A7W7TAF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030713908" evidence="2">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20544" checksum="87FC6FACC00E3AF8" modified="2021-06-02" version="1">MRDFLRPGILCVALVGTLAVACTSKEPGNGTAGSTPTVGVTTSAAGTKSATPRPKAIKLDGIDPCTVFTPAQTSQLKTVRTTRDDSDLLKNGSQAPLCNYGTTGAPWHSYGVGLVTSAGIDYWDESGNIDVKAVEVSGYRAATLGLSGVDAFCAVVVDVADGQQLYVDYHVDDQSQDVMCQNAAKGAELALATLRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF2</accession>
    <name>A0A7W7TAF2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein F4559_006371</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="11787" checksum="6C2636667F2A0F2B" modified="2021-06-02" version="1">MQPGGPNMQQILQQAQQMQQQLMLAQQELQDAEVTGTAGGGLVTAVVSGGGELKSLNIDPKAVDPDDVETLSDLVVAAVRDANRAAQELAAQKMGPLAGGMGGMNDLGDLGKLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCB0</accession>
    <name>A0A7W7TCB0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="10" type="ORF">F4559_006509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="136"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="342"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="46010" checksum="E7E02612F191C502" modified="2021-06-02" version="1">MIDLKVLRENPEAVRASQRARGEDESVVDALLSADERRRAAVARADTLRGEQKSFGKQVGKARGEEREALLAKGKELAAEVKAAEAEQHAAEEDLDRLHRVVPNVVHPDAPEGGEDDYVVVKHVGEPRAFDFEVKDHLDLGTRLGAIDTERGAKVSGSRFYFLTGVGARLELALLNLAVAQATAAGFSLMVTPTLVRPEIMAGTGFLGEHASEVYRLRDDDLYLVGTSEVPLAGYHADEILDGPRRYAGWSSCYRREAGSYGKDTRGIIRVHQFNKVEMFSYVRPEDAEAEHARLLAWEEEMLAKVEVPYRVIDTAAGDLGTSAARKFDCEAWLPSQQAYRELTSTSNCTTFQARRLNIRYRDEDGKPRVVATLNGTLATTRWLVAILENHQNADGSVTVPAALRPYLGLDVIRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCG2</accession>
    <name>A0A7W7TCG2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide peptidase SppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="1">
        <location>
            <begin position="94"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="31047" checksum="65FC4104B8EAFD69" modified="2021-06-02" version="1">MSVTDRIAARLPKIVGDRAERGPVVAAVRLHGVITPSPSPVARNALNLHSVESALTRAFEHDRLVAVALLVNSPGGAPTQSALIAERIRELAAKHKVPVLAFCEDVAASGGYWLACAADEIYAHGTSMVGSIGVVTSGFGLTGLLERFGVERRVYTAGTNKVRLDPFQPEKPEDVDWLRGLQGQLHAQFAEWIRQRRGPKLKGTDEELFTGEVWTGAQAVDLGLVDGLGTVRSVVAKRYPDAEIAVAEPRRTLLARLGLSGTSTRSGDFWPAALTALEERARWSRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM5</accession>
    <name>A0A7W7WTM5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ORF">F4559_000241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="43933" checksum="21C4AD930717D2A5" modified="2021-06-02" version="1">MAKAKFERTKPHVNIGTIGHIDHGKTTLTAAISKVLHDKYPDLNPFTPFDQIDKAPEEKQRGITISIAHIEYQTDKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTKEHVLLARQVGVPYIVVALNKADMVDDEEILELVELEVRELLSEYEFPGDDLPVVRVSALKALEGDAEWGEKLIGLMDAVDENIPEPEREVDRPFLMPVEDVFTITGRGTVVTGRIERGIVKVNEEVEIVGIKETSKKTTVTSIEMFKKFLDEGQAGDNAALLLRGVKREEVERGMVIVKPGTTTPHTEFDAQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDTTTMAVKLIQPIAMDEGLRFAIREGGRTVGAGSVTKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP1</accession>
    <name>A0A7W7WTP1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="26453" checksum="21CB611386D67187" modified="2021-06-02" version="1">MGVLRCREWARSSVGSVVGGADRVVGCRLRRPWRGRVRGIGSSGGCACRWIARCPAARGEWRAPRGPRPRLRAGRVRERASCAFRHREMCVQALSFGWPTVVAVGVRSRKAGHDGGRGRLCAEWWPVPPDRRKPFRRPGVGPGTAYPPTCAGGGAGGVGGPLPGLACPAPRVTGHGRVVRGRRSGLPVLDRSACGVVGRLRVCPPARGSGPCGGSVSVFRTVVACRSERVPVPLDAPMWFSSPLRPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP3</accession>
    <name>A0A7W7WTP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030778825" evidence="6">
        <location>
            <begin position="18"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="10"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="38515" checksum="0CCDEDDE1B0D26B3" modified="2021-06-02" version="1">MATTRSRLPALLALATAAFTTVLTEALPAGVLPEMSRGLSAGESATGQLVTAYAVGTALTAIPLSLVTARWRRRVLLLSGVSGFAVANTVTALSESYWLTLAARFGAGIAAGVVWALLAGYARRLVPEPLAGKAIAIVMTGIPLALSLGVPAGTALGEAVGWRWTFGVMSVLAAVLSAWIALAVPDFPGLPSGGPPPLRATLAMPGVRWTLFVTLVFVLAHNTLFTYIASLLDYHGLSDAKDLALLLFGIASVVGTAVVGALIDRASRPLLFACTVLVALAALALAALPVPLVAITVWGLAWGGVPTLLQTAAAVAAGPYADPAQAALVTLWNVAIAAGGVAGGVLLSQAGPTAPAYTAAVLLLFLAAVGRRNREPAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT7</accession>
    <name>A0A7W7WTT7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="7" type="ORF">F4559_000182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19322" checksum="C65DEEE16B647813" modified="2021-06-02" version="1">MGMLDPVKGFGVTFGTMFKKVVTEEYPEVQKVTAPRFHGRHQLNRHPDGLEKCVGCELCAWACPADAIFVEGGDNTEDERYSPGERYGADYQINYLRCIGCGLCIEACPTRSLTMTNEFELADDNRQKLIFTKEDLLAPLLPGMQQPPHKMLLGENEQDYYVNGPALAKEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU75</accession>
    <name>A0A7W7WU75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="19599" checksum="DE11071BF018C865" modified="2021-06-02" version="1">MAPEPERTSLLPRPLLAVAIGLPALLAAGVAAAGLFLGTGSETPGGPTTVPTGPLALVPVPAPKAASPECAGLLAKLPMQLLSSGVTLPRRELAAPAPEGALAWSDSTHSPLVLRCGLDRPADLEPTSQLRIISDVQWLEVADGPNATWYVVDRPVYVALTVPSDAGTGPLQDVSTTIRDTLPKTPVDTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN2</accession>
    <name>A0A7W7WUN2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21070" checksum="D91C185A31FD4CA0" modified="2021-06-02" version="1">MTYPPQWSGAPGGHPRQPYPPQPYPQQYQHFPAQGHPPQYDPYGGPPPKPGALGVVMTIHWVITALTVGGVVISLASSLSLLHAVNGLNLAFVALLALITVLLGVLHAVAAMSAAHRYFPNLIASRMAAGFSLVLGALSLRSIVTLGALTASALIGVGMVLLCLTALILGAQSSVKRWIVAKHRYSISQGHLPRNARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR5</accession>
    <name>A0A7W7WUR5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_001471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29633" checksum="7E80C1150EBA528F" modified="2021-06-02" version="1">MPLTPADVHNVAFSKPPIGKRGYNEDEVDAFLDLVEGELARLIEENNDLRQQVEQLDQQVETARADLEDARAKVAAGVGAGRVVDEPRRLAPVPPPSALEQTSPGGGGDHHVQAAKVLGLAQEMADRLTGEAKAEADGMLSEARTKSEQLLSEARAKADTMVNEARTRAETMLNDARTRADTLERQAREKASALDRDAQRKHAEVMGNITQEKNTLEKQIDKLQTFEREYRTRLKTMLESSLRDLQDRGPAAPSDGRQPGGYSFGARAEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUS6</accession>
    <name>A0A7W7WUS6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17068" checksum="A05AA0121E1ABD22" modified="2021-06-02" version="1">MSVPRTLIWTPAPTAELQRNLHRAGAGPAALVPVVSGTVLLPRRGIGFADAQKLAGRSRDVAEQATLVRWNEHAEVWSDGTDTGYRGRARPLVGTVRWWRLKAVEGTLDLPADVAEVRDLVDEGRADTWITNLPERSALPINMVLPVVPVTQGGAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT7</accession>
    <name>A0A7W7WUT7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="22497" checksum="EAD997DCEDCF7975" modified="2021-06-02" version="1">MVDVLVVARDEVSRAGFTTVLGAAGIDVVGSTGSGFEAVLIAGETRPAVVLLDDPGDMPVELVVARSASGTTRVLVLSAAASDETAYRLLRAGASGLLPRSAPAAGVVGAVRVVAAGGLLLGETFARRLVEGYTPRPVPREDLADRLSRLTCREVEVLRLVGTGLTNAVIAGRLSISEATVKTHLNRAMAKLDSTSRAQAVVIAYESGLVVPGRPISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX0</accession>
    <name>A0A7W7WUX0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane sensor domain MASE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="MASE1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34583" checksum="6B5D06E33C751394" modified="2021-06-02" version="1">MPIPPRLRPWGVYAAQLLAVTAAYYAGARLGLLQALVNDQVTPLWPPTGLAVVTLLLGGQRLWPGIAIGAFVVNATLGEPGAAFLISAGNTLAPVVACLLLRHYDFRLALDRTRDAIVLIVLGAFAAMLVSASVGAGSLLLTHGIDRAQFWTTWSVWWTGDALGVLTVVPLVAAVRTARRRHLTTRGRIEVACLLLGTAAVTVMAIATPVRLLYLVFPFAVWAGLRFQHLGAAPCALISTAVTARGAATGTGPWEGYEVYQRMVSLQGFNATVVLTTLVLSAVIAERNAALAAIERTCSQLSDMVTQYQPIVLGDMLPPRRQNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW7</accession>
    <name>A0A7W7WVW7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin-guanine dinucleotide biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="4">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="17429" checksum="2B60E0C3607A7D7B" modified="2021-06-02" version="1">MWDAIVLAGGRGSRLGGVDKAALVVGGRTLLERALDAVRGAGRTIVVGPRRDLPGGVLSVREEPPGGGPVAGLAAGLGSVRAERVVVLAVDQSGVTAATVARLLAVDGAAVLFDDRPQWLIGVWPTAALRAAVPADPRGVSSRSVLGGLRPVEVAALPGEARDVDTPEDLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW08</accession>
    <name>A0A7W7WW08_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="10"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26439" checksum="3DCB104F1C77300C" modified="2021-06-02" version="1">MSHALTESATMVGRGIRLSRRNVDTLVMALMLPLVMMALFVYVFGGAIAADGRYIDYVVPGIILLCVGFGASSTALSVVDDLRGGMIDRLRSMPIHAFAVLTGHVVASVVRNALATTIVVLAAVAMGFRPSATPLEWLAVAGLLLLYVAAISWLAAAMGVVAKTPEAAGALNFLMLFLPYLSSAFVPTDTMPAVLRAISENQPVTPLIETVRGLLTGTAIGSHGVIALAWSAGLLIASTTVAVMLYRRKVDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW84</accession>
    <name>A0A7W7WW84_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="12212" checksum="9D59A6A8B4296935" modified="2021-06-02" version="1">MLGAESATTVATNTAAPPPVDASSPPVSRRTTGTVAPARNADTATTYAAWYQPATENVCGAVSSQFSRGRGSANQDACTTAPAKPPATAPGTDSGGSPSRRRAWTTPYTTSGSTASPSVPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP1</accession>
    <name>A0A7W7WWP1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="431" mass="47072" checksum="51139656FA5E031C" modified="2021-06-02" version="1">MSTTASSTREDAGEATAGTESTNRERIQLPAELMHRDAGRPFDPPVALDRLADTGPAVQPITQRDGDTAWLVTGYAEGRAVLADPRFSSERFTARVLDKLSPEIRARVLDPDARAGSFIFMDPPDHTRYRRLLTGQFTVRRMRQLEPRIEAIVAEHIDAMIAKGPGADLVTEFALPVPSLVICELLGVEYADRDEFQDRTAKLLALDSTLEEVFDASDNLRKFMHRLVERKRAQPTDDILSGLVHAETDTPLTDAELVGIANLLLIAGHETTANMLALGTFALLEKPDQLAALRADPALIGGAVEELLRYLAIVHLGIVRTTLEDVEISGVTIPADSTVFVSVTVANRDGRVVDDPDRLDVTRPRAPHLAFGHGIHQCLGQQLARVEMTAGFTGLLGRLPGLRLDVDPADVPLRDDMAIYGVHSLPVTWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ7</accession>
    <name>A0A7W7WWZ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type oligopeptide transport system ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="446"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="881" mass="95396" checksum="1125B245435DA107" modified="2021-06-02" version="1">MLPRTPTWVPPALDQPPELPLTTTRPHSTAPVAAGWLEDYLRDPGGALLALLARLRDLALDWGPIAAPVLAVLITGIVLGRRWWARRCHELLLADARQVTVLAPPQVDPAGGAALWSNLVGLLRPGWRRAFTSQPHVACEYVFSEAGVAIRLWVPGLIPPGLVERAVEAAWPGAHTRVGPAEPPLPTPNEGQRRLVVGGELRLARPEALPIRSDFDADPIRALIGAPVGLGREEFACVQVLARPVTGRRVQKARRAARRVHTGGSTRLVGRVLDAITPGTGSRSRRTASAWTKTGALHSDPQTSLEYAAQNRAIVGKQRGSQFETVVRYAVATLLPADTDEAEVRRAREVARGRAHALAASFASYTEHNHYTRNRIRHPGAVVDSRRLGRGDLLSVPELAAIAHLPTDEAIPGIQRAGARAIAPPPGIATPGPEAKPLGVTDTGHQRPVALRVPDARHHLHVIGATGSGKSTLLGNMILADAEAGRGIVLIDPKGDLVTDVLSRLPRSAADRMVIFDADSKSRPPCLNPLDGGETDLTVDNLVSVFRRVYSAFWGPRTDDVMRAACLTLRNQEGVATLADLPKLLADEAFRSRVTAGITDPVLRGFWSWYEDLTDSSRSQVISPLMNKLRAFLLRPFVRDAIAGRHSTVDMSQVLDGGICLVRIPKGSLGEETTRLVGSLVVARTWQATTGRARTPQRQRRDASLVIDECHNFLNLPYPIEDMLAEARGFRVAMTLAHQHLGQLPRELREGMSTNARSKIFFNASPEDSRELSRHTAPRLSDHDLAHLGVYHAAVRLVLNGEEAQPFTMLTQPLPPAVPGRAREIRGVARRTARIRATEAATGGPATAGTRPPRSSSGPARPANRNEPVARPRSADPRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX22</accession>
    <name>A0A7W7WX22_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransf_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="37427" checksum="067CF38AC7046DF8" modified="2021-06-02" version="1">MTRVEQWIFVEQNDVGTLFHMAGLATPMALRVAVTLGLPDRLDEGASAALLAGELDVDPVALELLLNHLVTVGVLDKTDDGYRTTAFGAHLRVDADNMLSNLLNLDNAGGRADQAFVELFHSVRTGRSAYEYRYGQDFWADLAERPRLRESFDRQMTQRFRAHVPRIVAGFDWSRFATVVDVGGGAGSLLAAILDAHPWMHGHLVDLEPTAAVARRTFLARGLDERTRVIGGSFFDPLPAEADAYLLFDILHNWDDEHARRILGRCVEAVHSEGRILIIEGVGGRRATTESDLAMLTIFGGRERRLDELRALAEPQGLVLEGVTDLTDNRCLLEFSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX64</accession>
    <name>A0A7W7WX64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-2 C20-methyltransferase/precorrin-3B C17-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.130</ecNumber>
            <ecNumber evidence="8">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.130" evidence="8"/>
    <dbReference type="EC" id="2.1.1.131" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="244"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="484" mass="51914" checksum="91FA8DEF22D5C006" modified="2021-06-02" version="1">MTGRLYGVGVGPGDPELVTVKAARLIRDADVVVYHSARHGRSVARGIAEPYLREGQVEEQLVYPVTTEDSDDYQGEMDAFYAECAARLAAHLDAGRDVVVLAAGDPLFYGSYMHLHKRLAHRYETEVVPGVTSVSAGAAVLGTPLVERDEVLTVLPGTLPPAALVGHLSHGDPVAIMKLGRTFPAVREALERTGRLDEAWYVERATTGRQRTAPLSEVDPDGVPYFSLALLPSGPPAPTGEGEVVVVGLGPAGPEWLTPQARRALAEADDLVGYVTYLDRVPVSARQRRHASDNRVESERAAFALDLAKRGRRVAVVSSGDPGVFAMASAVLEVAAEPEYADVPVRVLPGLTAAHAVASRAGAPLGHDYAVVSLSDRLKPWEVIAERLEAAARADLVLALYNPASRTRTWQVAAARDLLLAHRSPDTPVVIGRDVGGPEETVRVVRLADLDATTVDMRCLLIVGSSRTRISARGTVFTPRRYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX93</accession>
    <name>A0A7W7WX93_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tryptophan-rich sensory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PTHR10057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031361503" evidence="7">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="16791" checksum="FDFCF9DB62A16D49" modified="2021-06-02" version="1">MIGQRSRPVLGLVAFAAAVGVTALIGALAATSAGERYESLTLPDFAPPAWLFGPVWTVLYVLIALSGWLVWQRHGLVWEHVVYGVQLVLNAAWTPLFFGAGKLGFAFVDIVALLVVIALLLALFVRRHLVAGLLLVPYLLWVGFATMLNATIVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA0</accession>
    <name>A0A7W7WXA0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="35059" checksum="10188B0AD4E14931" modified="2021-06-02" version="1">MTTTSLKATDTGPALRLLSLGAGVQSTTVLLLACEGEIARFDVALFADTGWEPRVVYTNLDRLASHAERKGIPVRRVSAGNIRADALDPRHRFVSMPLHTLNPDGSRGLARRQCTSEYKIIPLKKAARELLGYPHPRRVPRGVFAEQAIGISIDEFHRAKDSGLRFLRNFFPLLELGFDRARCVDFLAERGFGETVKSACVGCPFHGNAGWRWVRDNDPQGWAEAVEFDRAIRHGYPHATTHGQELRGQYFLHRSCLPLDEVDLDAPTKSRSKKHLRLITSDSADVAADSVEEDGDPDGCSPWSCRSGTPTTSERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC6</accession>
    <name>A0A7W7WXC6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="38219" checksum="01AB4CD6744FB309" modified="2021-06-02" version="1">MSSSPSLPSGRVHMVDLFAGPGGLDVAAHWLGLSVHGVEWDRNACATRTAAGLATRPDDVRAFGPADFPEATMLAGGPPCQTYTVAGGGAGRRALDQVLGFVKRMAAGDDRVADDLAKLDDERTGLVLEPLRWALAADRLGRPFEAIVLEQVPAVLPVWEAMKEALEGIGYRAVCGILNTEEFGVPQTRRRAILIARRDRQPELPRPTHHGYRKGIPRTATTDLRPWETMGSALRRDHPFVVISNYGTGGDPKARGRRTSDEPSATVTGKVSRNRLVSPDGAELPRFTLGEAGRLQTFPVDYPWSGGDIAQQIGNAIPPRLAAHVLAAALGRTLDPAALDAAIEGSWSRTRDSAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY30</accession>
    <name>A0A7W7WY30_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA1 family inner membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="388" mass="38830" checksum="F32DEAF80E54023B" modified="2021-06-02" version="1">MAGGAVMPPALIALALGAFGIGTTEFVIVGLLPEVSRDLGVSIPTAGLLVSGYALSVVVGAPLVTALGARLPRKTLLLGLMGLFVLGNLLCAVASDYSVLMVGRVVAALCHGAFFGVGSVVAADLVAPDRRARAIALMFTGLTAANVLGVPLGTALGQAFGWRSTFWAVTALGVAGAVGVLALVPRLPGSDGLRGELAVFRRPGVWLALATTAFGFGAVFASFTYVAPMMTEVAGFSSGAVTWLLVLFGAGLCVGNVLGGRLADRDLMPNLRRVLLALTVVLLVFVAAAHWPVAAVITIALFGVAGFATVAPLQARVLGQAEGAPALASAANIAAFNLGNAAGAWLGGVAIDAGFGWTAPNWVGAALAACALVLASVRVAPALVKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY95</accession>
    <name>A0A7W7WY95_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS30 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="16849" checksum="8B435F8808891E0C" modified="2021-06-02" version="1">MPGHREGDIVVGKGGRSAVATLVERTGRFLVLVPPTGRDSSTVTQAIISAVGPLPASIKRSLTWDCGSEMALHKDVAATGPPVFFAHPHSPWERGSNENLNRIVREYLPKGVGITSDPHYPAAIAAEINDRPRKIHDWRKPGEVFTELLEPDASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA7</accession>
    <name>A0A7W7WYA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20578" checksum="DC203ED607D2F531" modified="2021-06-02" version="1">MIDVVRCAWGDSTPDYRDYHDTEWGVELHGDAELFERMCLESFQSGLSWITILRKRENFRRAFADFDPVVVAGYDDADFDRLMADASIVRNRAKINAAVANARVLAAMDEPLDDLLWSFAPKTHVRPATIADVPAVTAESKAMAKELKRRGFVFLGPITCYALMQATGMVDDHVATCFRAIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB3</accession>
    <name>A0A7W7WYB3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliE</name>
        <name evidence="4" type="ORF">F4559_005718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="10565" checksum="BA791401C92765D4" modified="2021-06-02" version="1">MSSPISAIGAVSAPIAPISLSGATSADYAEKSSFGDMIGAALAKTEQAQSKASDLAVQLSTGDLDDPQEYLMAATEASLSTQLTVAIRNKAVDAFNEIMRLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH9</accession>
    <name>A0A7W7WYH9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">F4559_005824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7603" checksum="C46182E9B412AE42" modified="2021-06-02" version="1">MTEPGYEQARDELVEVVRRLEAGGLSLEDSLALWERGEALAKSCERQLAGARERIDQALSVTEEDVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM0</accession>
    <name>A0A7W7WYM0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosortase/archaeosortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18273" checksum="600E9628B2E6C4B7" modified="2021-06-02" version="1">MAFAVPRTAHLNRVVVVALTVVATGLVLAHRAYRTVEISLSGLLLDALSGYGVEVVADRQTVYFGLGSDTPLGLRMTPECTSAFLVVPLLVIGAVMTALRPRITRRVLIALGVAATAVVVVNQLRVLTLVGLVDWLGVDRGYHWGHTLLGSMVSVFGGAAALVAFVWLATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN7</accession>
    <name>A0A7W7WYN7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="28057" checksum="25AD866EB6D3BC99" modified="2021-06-02" version="1">MSDNGVDEHPKEKQRGPVVLRRQRREELTTTDQRLLDSRGPSDWVHTDPWRVLRIQAEFVEGFGALAEVPSAVTVFGSARTQRDHPEYELGRGLGGALAAAGYAVITGGGPGAMEAVNRGCSEAGGFSVGLGIELPFEQGLNPWVDLGVNFRYFFVRKTMFIKYSQAFICLPGGFGTLDELFEALTLVQTKKVTKFPVVLFGRSYWQGLYDWVKNSALASGKVGEKDLALLHLTDDIDDAVRVVDESHKAWGDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYP4</accession>
    <name>A0A7W7WYP4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21534" checksum="4FDCC193E8E769A0" modified="2021-06-02" version="1">MSTDAPNQPQPQYPQQPFQQQPQFNQAPAAQVPQEPKKRGVLGRILSALIGIAVVAAVGYGIKYFTSDAAQTKAGDCASLTGTTSKPEYKTVDCGAAEANYIVGKALNTSEKCDGDYDEYIETGRGPQTRLCLVPKLEEGKCYNLQGSTMGYPAVACGGGGDVLKLVKQVKDVADTAQCDFVEGALAFQEPKLTLCFEPTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ07</accession>
    <name>A0A7W7WZ07_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4,5-DOPA dioxygenase extradiol</fullName>
            <ecNumber evidence="6">1.13.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016701">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LigB" evidence="5">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="27720" checksum="0E559A40BA10DDDE" modified="2021-06-02" version="1">MMPVLYLGHGAPPLADDERWASELNAWSATLPRPESILIVSAHWENDPLTLGATRTVPLTYDFWGFPRRYYEVTYEAPGAPELAAAVAGLVGEPVVQDEERGLDHGAYVPLKEMYPDADVPVLQMSMPTLDPRRLFEVGRKLAPLRDQGVLIVGSGFMTHNLSCVDMSRPADYAPPSWSAEFDDWAGRALDDGDVDTLLDFAHKAPAAGIAHPRTEHLAPLFVSLGASADQRSRTTVDGFWYGLSKRSVQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB6</accession>
    <name>A0A7W7WZB6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiamine-phosphate synthase</fullName>
            <shortName evidence="9">TP synthase</shortName>
            <shortName evidence="9">TPS</shortName>
            <ecNumber evidence="9">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="9">TMP pyrophosphorylase</shortName>
            <shortName evidence="9">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiE</name>
        <name evidence="13" type="ORF">F4559_006165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 10">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9 10">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 9 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="12">
        <location>
            <begin position="18"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="9">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="9">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4968806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22009" checksum="801525EF1BF51801" modified="2021-06-02" version="1">MPGLDASALRRRLADATLYLCTPNRPDLGEFVDAALTGGVDIVQLRDKTLEARQELAALEVMAEACARHGALLAVNDRADVALAASADVLHLGQDDLPVSVARRIVGDDVVIGRSTHDVAQAGAAAVEPGVDYFCTGPCWPTPTKPGRPAPGLDLVRATVGAARPWFAIGGIDGRRLPEVLAAGATRVVVVRAITEAEDPRAAAVSLKLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC5</accession>
    <name>A0A7W7WZC5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">F4559_006709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8959" checksum="734AD8998506A513" modified="2021-06-02" version="1">MAKPPVRKPKKKVCAFCKDRNANSIDYKDTTLLRKFISDRGKIRARRVTGNCSQHQRDVAVAVKNAREVALLPYTSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZI7</accession>
    <name>A0A7W7WZI7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24035" checksum="7AEC987CA716CE12" modified="2021-06-02" version="1">MTRPVALITGASRGIGAAVARALAPTHDLLLGGRDLTALTTLANELPGARPWPVELTDTEALEAAVFMVDRLDVLVHSAGIAELGPLASASAETWRRTLEINVVAVADLTRLVLPKLRESAGDVVLINSGAGLQANPGWGVYAASKFALRAFGDALRAEEPKIRVTSVHPGRTATDMQRDVRAQEGAEYEPENYIDPASVADAVKTAVLAGPDAHVTQVVVRSRPRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE4</accession>
    <name>A0A7W7SXE4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family ferric uptake transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16606" checksum="4C2A494976E4E225" modified="2021-06-02" version="1">METAGGRKALRKTLHDRGMRMTPQRQLVLDAVRELGHATPEQVCRRVQETAPTVNITTIYRTLDLLDRLGTVRHTHLGHGAPSYSIDEHEHVHLVCHRCGRIDEVPCDLLEPLSGTLERQYGFELDAGHLALSGTCRSCVESYVPEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXJ6</accession>
    <name>A0A7W7SXJ6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoD</name>
        <name evidence="9" type="ORF">F4559_000177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="8">
        <location>
            <begin position="171"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="456" mass="50338" checksum="0E4AC88A52BDF1E8" modified="2021-06-02" version="1">MTEQRVSDYTTGTDTSAEGRASDAYAGSRQTTEGTVYTVTGGDWDDVLADAAGEERIVMNLGPQHPSTHGVLRLVLELEGETVTQARSVIGYLHTGIEKNVEYRNWTQGVTFVTRTDYLAPLHHETAYCLAVEKLLGVEVPYRAQVARVILMELNRISSHLVALATGGMELGALTGMTAGFREREEVLHLLEFLTGLRMNHAYIRPGGLAQDFPQGAENRIREFLKVMDSRLPDYDKLLTGQPIWRNRLQGIGYLPVDACLALGITGPILRSAGLPWDLRKIEPYSGYEHYKFDVPTSNEADSFARYRLRVEEMHQSLKIIKQGVDFLQPGPVMVEDAKIAWPAQLTIGADGMGNSLEHVRKIMGQSMESLIHHFKLVTEGFQVPAGQVYVPVESPRGELGYHVVSDGGTRPLRVHMREPSFVNLQSMPAMCEGSMVADVIASVASIDPVMGGCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXV6</accession>
    <name>A0A7W7SXV6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="39564" checksum="C77F97602E159A6F" modified="2021-06-02" version="1">MRDLVEIGMGRTARRAYELDDVEIIPSRRTRSSKDVSTAWQIDAYRFEIPLITHPTDAIVSPGTAVAIGELGGLGVLNAEGLWARHGDVEEALFRLVRAVEDTDDPAAPVRVLQELHAAPVRMDLIAEAVKQVRESGVTVAVRVSPQRAAEFAPDLLAAGVEILVVQGTIISAEHVSRDGEPLNLKSFIADLDIPVIAGGVGDYRTAMHLMRTGAAGVIVGYGYAPGVTTTDSVLGIGVPMATAIADAAAARRDYLDETGGRYVHVIADGGVLTSGDVAKSIACGADAVMLGEPLAAAAEAPGQGLYWTASSAHPSVPRSHVSTGVDQVVDLSSLLFGPSVDPRGVTNLFGALRRAMAKTGYSDLKEFQKVGLTIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXY5</accession>
    <name>A0A7W7SXY5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030753548" evidence="6">
        <location>
            <begin position="22"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="7">
        <location>
            <begin position="370"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="491" mass="51176" checksum="485862E825CB78BC" modified="2021-06-02" version="1">MKNALWTTAALALAIASPVQADPTDDYVVVLTDDADPDAITRKHEAKPDHTYTHALKGFSAHLSQDQARKLAQDPEVAYIRQDVVLTKQDTQSPVPSWGLDRIDQPAPPLDGSYTYPNGGEGVTAYVIDTGIQVDHADFGGRAAHGYDMVDDDNDATDCDGHGTHVAGTLGGKEYGVAKKVHLVAVRVLDCEGEGTLAGVMAGIDWVTGNAVKPAVANMSLGGRADETLDRAVRASIASGITYGVAAGNDNGSDACTRSPARTQEAITVGATTKDDTRASYSNVGTCLDVFAPGSAITSAWIGGSNTEAHVLNGTSMATPHVVGAAALYLSGDPTARPQEVRDALVAASSPNRVADAGTGSPNRLLRVTAAPDPDPSGCQPVADTTAHPIPDPGTATGTITTTCTGKASPRTTIRVRIRHPYRGDLSITLVTPSGTTRLLKAPAGTDARDDVDDLYRVDVSTENATGTWRLRVVDHVAQDAGTLESWTLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW1</accession>
    <name>A0A7W7SYW1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22604" checksum="B3183227C2B93188" modified="2021-06-02" version="1">MAVQEHQRPPDVVLVRWRSGRIHISTDGRTTVCGSVIRPDRARIPDDGTAWAEQVDCYNCAYRYTPPGYIGPTSGRDFPLKRECPAHPGRGQAAGSCHLCDPLVLRPQNWPCPNGCTDQLDHSPLSRYTRCTVFPPLRDAGPDGRCPDACESTELAMRRANPGLYFDLADSASMTCYHCGGEVCVGCQRVAVDGIFGFCVRCGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ02</accession>
    <name>A0A7W7SZ02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (DUF305 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="24483" checksum="DA02DE5AEDCD2D65" modified="2021-06-02" version="1">MEEVEQRRGLTATRTVVVSVAVVAVLLLGAAIGLLIKLPGTPSSSVPARESVDVGFLQDMAVHHLQGITMANAARDKTTDKFVRQLAFDIQSTQLEQVGRMKGWLSLWGQPEQSVDGTHMAWMESGSHEHSSAAPSAAVSGLMPGMATSEELSKLRSLSGTEFDVYFLQLMLRHHQGGAPMAKYGSEHAGEAVVRTLAANMLKSQTGEADYMRTLLAERNAQPLPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ43</accession>
    <name>A0A7W7SZ43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000864</name>
        <name evidence="4" type="ORF">F4559_000913</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="109"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="36147" checksum="6357F57B33446B63" modified="2021-06-02" version="1">MKKSCTLTGTSRATHYRHANRKGPMHGPRPARTPPPQALDADERARVLEVLTSPAYRDLAIPQMWARELDEGRYWCSISTMYRIARAQGQVRERRRIATHPPRTRPELSARGPGEVWSWDITALKGPVKGVWYKCYVVLDIFSRYVTGWLVAAAEDAVLAKDFLAEAIARNGTEPHTIHADRGGAMVSKPVSELLTDLGVLRSHSRPRTSNDNPYSEAQFKTLKYMPDFPDRFGSLADARLFCEGFFLAYNHEHRHSGIGMHTPASVHFGTAGRIRDQRQATLDRAHARHPERFARRPRPPALPEVAWINQPLDQPQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZK0</accession>
    <name>A0A7W7SZK0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="3">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuB</name>
        <name evidence="5" type="ORF">F4559_001220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01035">
        <property type="entry name" value="LeuB_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023698">
        <property type="entry name" value="LeuB_actb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="4">
        <location>
            <begin position="2"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="36631" checksum="C038B57CA5362AF8" modified="2021-06-02" version="1">MRLAVIPGDGIGPEVVAEALKVLGEVVPAAEITRYDLGAARWHATGELLPESVLGELRQHDAILLGAVGDPSVPSGILERGLLLRLRFELDHHVNLRPARLYPGVRSPIADPPEIDMVVVREGTEGLYAGNGGLLRKDTPHEIATEVSINTSFGVERVVRDAFARAANRPRKHLTLVHKTNVLTHAGSLWSRVVEEVSLQHPDVTVAYQHVDAATIHLVTDPARYDVIVTDNLFGDILTDLAAAVTGGIGLAASGNLDVTRRNPSMFEPVHGSAPDIAGQGIADPTAAVLSVALMLDHLGESEAARRIEASVAFDLATRDHTSPGATYAVGDRLAALVSSNARAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZP3</accession>
    <name>A0A7W7SZP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_000985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031322671" evidence="9">
        <location>
            <begin position="37"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="336"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="10">
        <location>
            <begin position="409"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="664" mass="68948" checksum="CB59C7EA501C8A35" modified="2021-06-02" version="1">MSSFRLSSFRGRLLAVLVPVVVLGLAVLSVFVVVSATTLEEDAQRGHGRDVAESLARQVETRIAAARAAERAIVATGGVLPTENRPLLDEVVRASLAATPEIFDMYLCFEVPGDPRYPLSGVQQYLWVKDANGTPVRQDLDDAANAEAIKYDWYTQPKRTNAESIVEPYYDENLKALMTSVTAPIVQNGKTVGIAGVDVTLDQLSQQVSAAKVSDNGYAVLLSRQGMLLAAPDASGVGSKTLEQVASEPARDTAAALTSAIAANGSGTLDGLDPLSAEASDAVVTWAPVEGTGWTLATVTPMDDVLAPVAALRTKLIGFALGIALVLLATVWFTTRRLTARMPVLRTAALDIARGRLDVTLPRAGRDELGELAVAFGEMVATLRRTADHLRRIASGDLAAPVRPAGPDDELGNALVEMQRGLTSSVRAVVETAGTLSGSAEALRGQAGELRESAAVTSSQSAAASVGAAEFSASVAEIASTISRGADLAMDAEQATATMTAQLHSLAGSSAAIADVVDVITRIAAQTHLLALNATIEASRAGEAGRGFAVVATEVKSLAESTTTATVSVTERIAAIQSDVDGTVRVIERIGASIRDMTELQGVIVAAVEEQSAASHSVRESIGHVADVAGRTETNVQAGLGLADDLADAVGRLEEVSKGFRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT1</accession>
    <name>A0A7W7SZT1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="42"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="32866" checksum="30F218DF37F512DB" modified="2021-06-02" version="1">MVDVAPRGPSGEEPDHSSGEEEVESSPKRGRKDEKRKGSFWRELPILVGVAVVLAIIIQTFLAKVYMIPSESMEQTLHGCANCYGDRVLVDKITYDFTDPSPGDVVVFHGPDTWINQDFVAPEPENPILRALQKAASLIGFPQANEEDFVKRVIAVGGQTVQCCDDKNRVTVDGKPLDEPYIFWEPGRSSSQDSFAELKIPDGYLFVLGDNRNDSCDSRCQGDGREGGLVPVDNVVGKVRVVVLPPSRWQGVGDHDPQTVAIGAPAWQDAIPAGAGFAAAWPVMFLGRRARARLRRQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0B3</accession>
    <name>A0A7W7T0B3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type VII secretion integral membrane protein EccD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="5">
        <location>
            <begin position="96"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="464" mass="47440" checksum="84E3A4ACEC8884F5" modified="2021-06-02" version="1">MATGTTVFSRVTVVAPRTRIDVALPADVAVADLLPMLLNMAKEATPDGGVRHGGWALAKLGDSPLDPSRTLASLGVVDGELLQLRKRNENPPPPLYDDVVDAIAESDPDSFRPWTKETARRYGHLAGALALITSAIAVLLAGPLAGGGSLVPAICAGVAAVLALAAGSVVSRAYNATGTGVLIAASGGLPMAYVAGLYTVPGQVDRPNLLLASVLVLIVSSAAILLIGKGITVFIAAATAGALSGLAFLVGLFVDETVQGIAAGTAAVSLAALSMLPRLTIQLAKLPLPTVPGSAEDLKEDTGFPEYAVIERRTANAHEYLTGMIIGCGAVAALFSIIAATDGTMWGPLLAIVVTLVLMLRGRAYANGAQAVALLVSGMLTGTGVLIGWLVESTPDHRLLYVFGSLLVVGAVGLVLGVIVPGQKFSPVLRRTVDVLEAILIAAVLPLALAVLNLYMAMRQLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0F2</accession>
    <name>A0A7W7T0F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system sensor histidine kinase DesK</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="180"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="37908" checksum="52AFE0DC7FCA30EF" modified="2021-06-02" version="1">MDDLVRVRRTILAGVAVLVLCCLWVPAAVLARDPDNWLGMVGLGVLVAGHAAVLRFVTEPPAPRWALWVLLAATAVSILLVAPVGPADRYTWAWIGGATAGILPFLITGRSRWPAAVGAVGLAVAVGAVTGGSPVVHGVIAASVGAAVVGGTVVPLWLWTLLLDARAGREARARLAVTEERLRFARDLHDLLGHRLTVIALKSELAERLAAADPDRAARESAQARHLAATALAEVREAVAGYREVDLADQVAAAAGVLRDAGVRCATTVAPVPSEVAARLAFVVREACTNILRHSAAAWCTIDITSDGEGIGMRIVNDGVSGTGPDRHAFGLRGMTDRVAEVGGTLRVERDGDVFALDVAVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H8</accession>
    <name>A0A7W7T0H8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase-like lactoylglutathione lyase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14886" checksum="492738907F7E20F8" modified="2021-06-02" version="1">MDIKLSHSFIAVDDQDKALAFYRDVLGFELRTDTDLAGFRWLTVGIPGRPDWELVLENPRMGRSPEDGAAVAALAAKGVLGTLIFYVDSCDELFERVSASGAEVVQEPIDQPYGVRDCAFRDPAGNHLRFSGPVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X3</accession>
    <name>A0A7W7T0X3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="13521" checksum="6304BF07F1CA8930" modified="2021-06-02" version="1">MFDAGGGGGKVEFVAETVSGGAAGSALVGSQTKFSVDPAQARKLIDGLTLALDKLIEIGRQADQIRTAESPGKDPYSGAATKAIRAAAGMDAGGYGWANKQACDALTKTIDNIEAALKQYESTENAAEQGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z0</accession>
    <name>A0A7W7T0Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YcfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10097" checksum="0B9EF7B803BC4E90" modified="2021-06-02" version="1">MKSGWDQFEDDAGLHWKDRATRAAYRATVTTGAGWLGGMTGRAFGTWYGGAIGSVLAPGVGTAAGAALGGLVGGIGGGAAGAALGEKAADHSIDSMPKWEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T131</accession>
    <name>A0A7W7T131_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12013" checksum="0677020C5FFD9CD1" modified="2021-06-02" version="1">MAASRALAYARDAHGMFIEPDAVDSLVTGLRDLRDALDLIAQESFFVASHTMPIGAGYAGEIGRMFQDIASRSTMTVIPDLIAGLDGLIGQLDRSRASYHAVETAAAAAFDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T150</accession>
    <name>A0A7W7T150_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reactive intermediate/imine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="13573" checksum="DBF92102EDE62D42" modified="2021-06-02" version="1">MAKIEIRTENAPTPVARFSQGVRKGNILQVAGQVAFDPATGDIVGTTVAEQTRQTFKNVQAVLAAGGASLADVVMVRVYLTDTAHFAELNETYAEFFTEEPFSARTTVYVGLPAGLLVEIDVLAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T154</accession>
    <name>A0A7W7T154_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13631" checksum="C6E9F558655F1C01" modified="2021-06-02" version="1">MTGWRYMPDAHGRPPCPCVVCQPLGAYGSAKIRTRLSREWPEPTKPEPMARLADAGGPLELREVLYEPGGRGRGDADALAYLVDHPDAGVREALAEALRSYRDGRALQARLALDPDPEVRAAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T160</accession>
    <name>A0A7W7T160_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="538" mass="55519" checksum="AF5019A5A40AE105" modified="2021-06-02" version="1">MTEPISVEIVRTPNREQVATVVSDLLRESVPSRLSAGDPTLWGPDAESEAAIRLSWTTLHETSRPLVARIAALRAELLDAGVDRVVLAGMGGSSLAPEVITGTAGVPLVVLDTTDPGQVADALAGDLDRTVLVVSSKSGGTVETDSHRRIFEKAFADAGIDARSRIVVVTDPGSPLAAQAEEAGYRAVFPADPNVGGRYSALTAFGLVPSGLAGADIGRLLDEAAAVAPLVAADSPDNPAVVLAAQFVVAHAHGAEKIVFADTGSGIKGFGDWVEQLIAESTGKHGTGLLPVVVEGPGAPGFVDARSDATTVAIGPATGSSSIAVEGPLGAQFLVWEYATALAGRGLGINPFDQPDVEAAKKAARSLLDAPASTPAAPAFVDGPIEAYPSEGWLPGDVKTVAEALKALVAAAPDHGYLSVQAYLDRIDDASFALVRPELARRAHLQTTFGWGPRFLHSTGQYHKGGHRNGVFLQLTGASESTVDVPDRPYDLGTLQLAQALGDGQVLAGHGRPVLRLHLTDRVAGLAQLVEAIQEDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F9</accession>
    <name>A0A7W7T1F9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="659"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="692"/>
            <end position="699"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="953" mass="98651" checksum="F277F92B0AD8DE48" modified="2021-06-02" version="1">MALSSRLRGRWSLPALVLVVALVGAVVVWTRQGDDPVPVSTRDAVIDVPESPDSDRTIGIDTTLYLPTRTPAPAVLLAHGFGGGKASVTTQATELARAGFVVLTWSARGFGRSAGQIELNSLDHEVQDARKLLDWLATREEVRTDGPGDPKVGVTGGSYGGALALSLAGVDKRVDTIAPVITFNDLTQALLPNAASTTDVDTTTPAPGAFADDGVFKRSWAGIFFAAGLTGGDLASPGQEAAEPGRDDDGQQAAEVPQTGTGTERPTTPRTPTNGSCGRFAPTVCAAYTEVATTGKAGRTTLDVLRRASPATVAGSITAPTLLVQGEQDTLFGLDQADANARQISANGTKVKTIWYSGGHDGGSPGPELRARIADWLAYHLDGRGTDPGTGFEYTVVGAFRSSGAQSLRTVVAGDYPGLQGRPGTGRRAVALDGDEQVVVNPAGGNPAAVSGLPGLGSVVSRSSALSSRLSLDVPGQAATFTSAEVASQILVTGAATVRLRVSAVTGPQGSAATGPAEAVLFAKLYDTDGEQSRTLPGSAVAPIRVRGLPADGSPVEVTVTLPGIVRPVEGGHRFQLVVSTTDQAYANAVEPAAYRISLAAPDLSVPVVPGVNATSEVPATALWGIAVVLLACLAAAVIAWFRRRLTADLDPELARVPLVIEGLTKSYPGGLRAVNDLSFRVEHGQVLGLLGPNGAGKTTTLRMLMGLIQPTDGTIRVFGHRVRPGAPVLSRIGSFVEGSGFLPHLSGAANLRLYWAATGRPAEQAHVAEALEIAGLGDAIDRRVRTYSQGMRQRLAIAQAMLGLPDLLVLDEPANGLDPPQIHQMREVLRRYAAAGRTVLVSSHLLAEVEQTCSHVVVMHKGALVAAGPVEEVATGGGEATFRVDRPAEAATVLGDLDGVHNVHVDGDQVHASLNGTPRAEALKALVAAGVEVDQAGPRRRLEDAFLELVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U4</accession>
    <name>A0A7W7T1U4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002383</name>
        <name evidence="4" type="ORF">F4559_004581</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="487" mass="54308" checksum="BB85EA61E1A3DECF" modified="2021-06-02" version="1">MISVHHLDPRSALGALSGFRREFHRCLTRRADGLFELADAVLCADGPVRTLVGLSLAPEHRRGHGGLYDAVNNGRIEVDRLRDALAGTPLPRAADGRLVLAVDVSPWLRPDGATCPDRTFCHVYGRGRGEHRMIPGWPYSFVAALETGGTSWTALLDAVRLPPGADLAAVTAAQVRGVVQRLIAADQWRRGDPEILVVFDAGYDAPRIARLLEDLPVRVLGRMRSDRVLRRPGPPRVHNPLGGRFRKHGGEFVFGDPATWGAEDVLTRTDTRLYGTATAQAWNRLHPRLTRRAAWIDHSGPLPIVEGTVIRLTVERLPSGGVNKPVWLWCSDPDSGPVEVDRWWRAFLRRFDIEHTFRLLKQTLGWTRPRLRDPEAADRWTWLILAVHAQLRLARPLVADLRHPWERPAEPARLTPTRVRRGFRNLHMKIARPAAAPKPVRPGPGRPPGSKNRATAPRFDVGLVLATGRAHTRPAHHKKGTKPRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T252</accession>
    <name>A0A7W7T252_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22399" checksum="7C0C9F2EDAF7E7CB" modified="2021-06-02" version="1">MLTIQGPVERGRAPRQVDVPDGHSAAFGGCGCDSCAFDIRLPGAVAPDFRGELDADRTTWWVTNTGDREPLLVADVDHPDETVAVRPGERVPFAFDMALIRPSTGPLSVTVFATLARSRRAAARPCPGLDPVAVPHLDRTSRYYAVLAELCGTGPMPTSAGIAARLGMSPRAVDAHIDYLIDKLGIPAPAIRSTGWKRTALVAHVRRAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A8</accession>
    <name>A0A7W7T2A8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26593" checksum="E3D92D62A7EA2D2F" modified="2021-06-02" version="1">MDDALPTEIALMWGLTPESRRGRRPSLSVVDITRAAIGIADEEGLAAVSMARVAQRLGNSTMALYRYVKSKDELLALMSDAALEEPPDPPEGDWRAALHAWACAALAAMRRHSWFARLPLTGPPAGPRNLRWFDRGLGALADTPLSEAEKVRIVLGLITLAHGELRMGVDLDRVHAEDPGAFGRAYAALLRRVADPRDLPAVGRVVDAGVFDHEADDPDDDTFRYSLGLYLDGVAALLHRLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F4</accession>
    <name>A0A7W7T2F4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized BrkB/YihY/UPF0761 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6910" checksum="A195B30F4784E8A7" modified="2021-06-02" version="1">MANKTYGSPAGVVVFLFWLWISDITLLLGAELDAELERGRRMATGESSGEDPVVPPRDTRAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N3</accession>
    <name>A0A7W7T2N3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007346">
        <property type="entry name" value="Endonuclease-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045939">
        <property type="entry name" value="YhcR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33607">
        <property type="entry name" value="PTHR33607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19886">
        <property type="entry name" value="DUF6359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04231">
        <property type="entry name" value="Endonuclease_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031272865" evidence="2">
        <location>
            <begin position="32"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6359" evidence="3">
        <location>
            <begin position="34"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="41522" checksum="CD58BBF2D4EC83CB" modified="2021-06-02" version="1">MRNRRWTHAAALVAAVLAVAAALLAPTANGAAPLTVAQAVAAQNGASATVRGYVVGQPTATTTVIRSGFPNDYALALADTPTQTDTTRMLYVQITSSFRAAWGLKTNPGLLGARLDVTGPLGAYFSHPGLTSPTAFARVGGTTTTPPTTPPTTTTGGGGGYDDTYYRTALGKSGPALKSALNVIIRTNTKISYDAVWNALKVTDQDPGNPANVILLYSGRSQSKSTNGGGVNDWNREHVWAKSHGDFGTATGPGTDLHHLRPEDVSVNSERGNKDFDNGGSAVAEAPGNRTDADSWEPRDAAKGDVARMIFYMAVRYEGNDGYVDLELNDSVSNGSAPYLGRRSVLLQWNLQDPPDAFERDRNQKIYDQFQHNRNPFVDHPEWATSIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Q4</accession>
    <name>A0A7W7T2Q4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="46600" checksum="C91E24D8FBB93941" modified="2021-06-02" version="1">MSDLKNAALLLLGRLIVRFEALRGDPGARLFGTAVSRDPYPVYEAVRAKGELVHSSMRLFMTSSHALCDRILRDPVFEAVPAGALSPVDVAEWREGRRLVNPVDESFLVLSPPDHTRLRRMVAPWFTPRGLRARAEFVDRVVDEYLDRVDGPFDLVGDFAARVPVRVIADLLGVPDDDHDAFDRWGAAMVVALDGAQDMKELRTLRDGLAEFEAFLDDLIARRRREPGEDVVSALVGRGDVDRRDLIATTELLLVAGFETTVNLIGNAVLAVVAHPEVRERLVAEPSFADAVVEETLRMDPPVQYTVRAPNTTVRLAGTTVPKGTPIALLLAGANRDPAVFADPHTFRPDRPEREHLAFSGGIHYCLGAGLARMEAAAALRGLFGRFPDLRVAGRVRRRQSRVLRGAARLPVAGGRHTMVETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W8</accession>
    <name>A0A7W7T2W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="20376" checksum="3C835E23C4953C06" modified="2021-06-02" version="1">MVMDGKVALVTWAGSGVGAAVAHRLDAAGARVAVLDADSTAVERVGADLWCGMAVRADASDPAQLASGVDAVVDHYGRLDVLVTTAPWTGPCTELSTVDIDDERWHATLGAGLDATFYATRAALRVMRSGVLVAVTAQCTHALHRSVLAGGVDALVQAVAKEAAPLGLRVHAVTTACPPDLAEAAERVHDLVADAPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T337</accession>
    <name>A0A7W7T337_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="2">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20300" checksum="3ABE42F21ADBEC38" modified="2021-06-02" version="1">MRAQDIMTSPAVTVTRDVPSRAAAALMAAHGFTSLPVLEDDRLVGIVTEADLIRIRYTDGEAGDTPVGEVMTTPVFGMDALAPVTLVARVMLADRVRCVPIVDGSRVLGVVTRRDLVRAFARADRSIEDDVRERLDAYGGHEAWTVRVDDGVVTIHASVADENAVKVATALAEAVPGVVDVRVPDDRKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T371</accession>
    <name>A0A7W7T371_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="478" mass="48846" checksum="AB87D2A46A860984" modified="2021-06-02" version="1">MTDTQVAGTHGTATPYRWRWYALVAVLAAEIMDLLDATVVGVAAPSIQADLGGGSTTVQWIAAGYTLAFAVGLITGGRLGDLYGRRRMFLLGLAGFLVASALCGLATGPGVLIASRVAQGLFGAMLIPQGFGIIRATFPPRELGAAFGAFGPAMGLSAVGGPILAGALVDWDLFDAGWRTVFLINVPIGLATLALAWKVLPESRAERGTRPDPVGMGLVTVGLLALVYPLVQGRELGWPGWAYGLLAASVPVLLLFAVHQVRRTRSGRSPLVEPVLFRSRAFTGGLAVGVLFFGATSGLMLALGLYLQLGLGFTALDAGLAQAPWALGVAVGAALSGAVLARRFGRPVLQVGAVVMAAGIVVVLTEVDGAVTGWSLAPGLAVCGLGMGLLIAPFFDIVLAGVTLPMVGSASGVLNAVQQLGGAAGVAVLGTVFFTRFEAGDQAGALHAVLWSTAALLLVTAVLAFALPRRAREDSTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3H9</accession>
    <name>A0A7W7T3H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030663069" evidence="1">
        <location>
            <begin position="32"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36852" checksum="E50B5302C852F0E9" modified="2021-06-02" version="1">MATCHSRTLSAALATVVGAGLLLVPVQSASADMPPFQGPRMAAQQGTKLWIKEGSIYEPWVEQGDDIRSFRLLGDRIGVLRTNGQLDVKAGDLGPGWHTVNTDSVTDFQLSGDRIAYTEGTDLYITEGDFGSPPVHQVGAPVKKFQLSGDRVAVLTPNGTLKVKEGDLGPGWADVATGVRDFELYGDEIVFNRSGNLWTLTELYGKPQEIIFAQGVTKFDVEGDRLAWLDRNGSLKAVHRTVNTVYAPVTISESVTDFQLSAKRIGYVENGDLWAQDGPLEAPSTVQETDIDGFEVDGYRLAVIKDGALLVKEGDLGPGWYVALPDKATAVEFQGPVLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P1</accession>
    <name>A0A7W7T3P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase</fullName>
            <ecNumber evidence="3">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="433"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="527" mass="56306" checksum="1AC1C619C29E5C68" modified="2021-06-02" version="1">MTAAFRAARDLLLAHGSDLDAARRRFRWPEPATFNWASDWFDVIAAGNTRTALRVVSGGEDVAVSFEDLSRRSARVANWLRALGVRRLDPVLVLLPNRVELWEVLLAAIKLGAVIVPTHTTATRVDVVDRVERAGVRHVVADVSLVDRVGAVPGNRIVVGGAVAGWTPYGLSRTAAGSFTPDGPTPASDPLFRYFTAGTTSWPKMVEHSHASHPVGHLSGMYWTGVRPGDVHLDVSSPGGAWSSFFVPWNAEATVVALTRVRPRPVLDVVRTRGVSTFCASPAVWRGLVARGLGARPPALREATSSGEPLDREVAERVLDAWGLEVRDGYGQTETTAQVGNPPGRPSAGLGRPLPGYDVEVLSPTGSPVRVGEVGELCVSLSPRPVGVMPAAGSAGHHRTGDLVRAAADGSLRFVARDDDMVKSSGRRVSPVELEQVLLRHPAVAEAAVVPSPHRLGDWEPKAFVVKAAGAGPDEEVAASVFTLVRTHLPEEKRVALLGFVPCLPRTSSGKVRRAALRTHCVPLHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R7</accession>
    <name>A0A7W7T3R7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="32205" checksum="47D9F1EA8BB35E0B" modified="2021-06-02" version="1">MRHETILDERYSNPVGDLGVEVMTLSVLRERAVPGGDRLAGPQRPRFHLLFVVDRGSGVHTVDFTPYTLGPGSVLWVRPGQVQQFGDLSSLQGVLVLFEPDFVPDPAPFGPTHWRLDVTERILVDSGIRHLAQEYAALAGRPHAAVLLGHLLSALLHRVLLAEPDVPRRGHTEAFTRFRDAVERDFTHRHRVADYARELGYSTRTLARATRDATGLAPKEFLDRRIVLEARRLLAHTDLPAAAIGTRLGFSDPTNFAKYFRQRTALAPGEFRLRTGRPIREGAPGDIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T0</accession>
    <name>A0A7W7T3T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolate oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="45946" checksum="3539DFD9C0F5F42A" modified="2021-06-02" version="1">MSHTGLTSGLPAWSTDPGELARVSVDRSGVAPDGLPDLVVFAQSVRDVRRTVSYAASRGVPVVPRGAGSGVAGGAVAGAGEIVLDLSGLDRIADLRPDDALAVVEPGVITADLDAAAHPHGLRYAPDPASAAFSTIGGNIATNAGGLRCVKYGVTRDAVLAVDAVLGDGSLVSTGRRTVKGVTGYDLTGLLVGSEGTLGVVVGATLRLSPLPTTTATAAAFFATADDAVAAVTSLQRRGLRPSTAELLDQATLRAIDDAQGTALHTRGEVFLLLQTDGYGAEAELAEAERLLRPSATHLETTTDPETAARLVAVRRAALPAVERYGRVLIEDIAVPRSRIAESITAVGDIARRTGVRIVVFAHAGDGNLHPIVVADSAPPERVDEAVAAIFEHALAVGGTLTGEHGVGTLKRPWLADELGEPVLDLHRRLKSVFDPAGILNPGKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T430</accession>
    <name>A0A7W7T430_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isopenicillin N synthase-like dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="174"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="36353" checksum="44BAD6C75F957A48" modified="2021-06-02" version="1">MSTALPLIDISRFRDPSADRAAFLAELREAAHVTGFFYVVGHGVPAELTTGIFDVARRFFALPLEERLEIENVGSPQFRGYTRTGHERTGGTPDWREQLDIGPERPVVDLGPDDPLWLRLIGPNQWPAALPELRATTLAWQAEALRVSREVLRALAASLGQPEDYFDRWFDDEASTHVKIVRYPGRPDRDQGVGAHKDYGYLALLQQDDVGGLQVRSGDGWIDAVPVPGSFVVNIGEMLEIATGGYLTATRHRVVSPPVGVERYSVPFFLGPRLDAVVEPIDLPPDLAAAARGVAQDADNPLHAAFGENALVGWLRSHPEVARRWWGDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C7</accession>
    <name>A0A7W7T4C7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">F4559_003702</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="19017" checksum="FADC96F9BC9E0DFD" modified="2021-06-02" version="1">MATEKAVLAGGCFWGMQDLFRRHPGVVSTRVGYTGGTVANATYRRHDGHAEAIEIVFDPARLDYRRILEFFFQIHDPTTRDRQGNDIGTSYRSAIFYETDEQKAVAVRTIEDVDASKRWPGPVVTEVARLGDFWEAEPEHQDYLERYPDGYTCHYVRPEWLLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R8</accession>
    <name>A0A7W7T4R8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="41287" checksum="CA229D9ACB159EDA" modified="2021-06-02" version="1">MDFRLWQVGTVLSAIGDEVTVVAFPLLVLFLTGSPAQAGLVAAVAAVPPLVLAVPIGVLADRASRRMLMVCGTVVGAVSVTSLPVAFGLDVLTLPQLYVVAFVSSAAATVYRIADTAALPRIVPPEVAAARSEVVWGVAALVGPPLAGLLFETAGPASPFLVDAVSFVAIMVCVLAIRTRLGADRPYPEVSWPRDLTTGARIAWGRPLLRTLTVLTSVGDFLFAGIGLLLIVLVRERGASTFETGTVFTAAALGAILGSLLAGRIEDRIGLRAAVSVKHWLTAALFPLLLLDLPVWVTGLAWGVVALQISILNVIQNRYLMGVVPNGSLGRVEGFLTFVEQGGLPLGYAATGLLLGWVGSRGTLFGYEAVLVVLAGAASLLTSGKGVDSDPGGNVRAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G3</accession>
    <name>A0A7W7T5G3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LmbE family N-acetylglucosaminyl deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016137">
        <property type="term" value="P:glycoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031482822" evidence="2">
        <location>
            <begin position="29"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="690" mass="73907" checksum="B8C7EA10C5744EED" modified="2021-06-02" version="1">MKKKLMCAMAISGVVLSLLPAAGVPALAQVASPDPVIVQVVAHEDDDILFMNPDLQNSVRVGRPVKTIFVTAGENEYGPGEHGTLPGRDRCKRGENLVREEYAYCRQRGAMAAYALMADQADEWDHGTLSVATGAGPVVVDQYTLRGRPEVALVFLNLPEYADVHDDVAPPGGASLVRLWERTASANTVLTWGTLAGRYTYDHDRLVDVLRGLFDHYLPTVIRVQDPEPDPRYRGDHGDHVHTARFAGEAAKAHTDATGRQGVDLINYRDYNISDSQMNLSGHPELPDGSRGQKAATFFAYTGWDTFTAENDSGYLAWTQRMYHRYPTGTTWVGANADGRLQAFAVLSGRLVTWYQRGDGEFGPGEVMVTPWRLLPGVTVNRNADGRLQVFARRADNHEIVTTWQVSVNGVFSHQWGSMGNPNAGTDSAAQVGAPVSILGPDGLLRLAVKNGGGGVSLISQQIANGAWNTGWADLGGGPGVQDPVALAIDRTNGVNVFAYAINGTVGVIQHWRAAAGQDYAQQPNLAGFEPSGPPAVAHNKDGRLDVFYRLASNNANDFAGMVGHTWQRSDESFSPTGEQIGGHGGVGAVAVSEAPGPWADSAQIPDARILVFTGNGGSGQSMTRQNEPDQGYTGSWDDLGSAHIAQPAAGVDRNGCVYSFAMTDAGSLTVRNQTTCTGAAPLDRYREIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H2</accession>
    <name>A0A7W7T5H2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="5">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="35649" checksum="7BCD01EFEA6B0653" modified="2021-06-02" version="1">MAVRVGINGFGRIGRDVLRCAVDRGADTIEVVAVNDIATPESLAHLLAYDSTYGPWTHEVDFGPDHLAVDGREIRVDAHADPADLDWGAHGVDIVIEASGRFRTRETAGAHLSRGARKVLITAPGKDVDATIVLGVNEDTYDPATHHVVSNASCTTNCVAPMASVLHEAFGIREGLMTTIHAYTNDQSILDRPHKDPRRARSAAVNMIPTSTGAAKAVGLVIPALAGRLDGSAVRVPVEDGSLTDLTVVLEHPATAAEVNRAFAEAADGRLKDVLVYSTAPLVSRDIIGNPASCVFDSQLTKSTGGTVKVFGWYDNEWGYANRTLDLCDLVAASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I5</accession>
    <name>A0A7W7T5I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045713">
        <property type="entry name" value="DUF6069"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19545">
        <property type="entry name" value="DUF6069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="17604" checksum="014BCF6B17411734" modified="2021-06-02" version="1">MTPRQDGDEPRRVEPTGRFELESPAEDTGRTPSNRYSAGLLWAGGAATAFVAGLLAVVGILAARGLLDIAVLAPKEDGAWGGADTLTYTLVVAGGALAATGLLQLLLSTTPDAVHFFTWIVLLLTAITAVLPLSLEVDTGSRVATATLNVLIGITIAVSLRDVARRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q0</accession>
    <name>A0A7W7T5Q0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031467011" evidence="2">
        <location>
            <begin position="27"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="33987" checksum="7BD322A9EEBF7043" modified="2021-06-02" version="1">MNTRILVTATAAVLLGGVAVGYTALSATPDTDDVATAPSTGGDRVQILTNGRLSSVDRTDPTGPRNVTEQRCDRAYEAAGTISCLRPVGALKAGELAVLDKDLKERRTIPLTGFPNRTRVSASGRMIGWTLFVDGHSYAANGFSTSTGILDTKTGTTVMSLEEFTAYVDDKPYQASDVNFWGVTFTADDNRFYATMSTNGHRYLVEGDFAARTIRTLIDNVECPSLSPDGTRIAYKAANNGDPQQGWRLSTMDLKTKTITPLPETRSVDDQPAWLDDDTVAYALQESDGTNNTWTVPATPEGTPTLYIPNANSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S4</accession>
    <name>A0A7W7T5S4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11806" checksum="FB2ED03F5B43E790" modified="2021-06-02" version="1">MTKDNLWKEAGVSRATMNRARLVLAKWDARVAECGGLTPGEARKNDEGTKLREQLADKTRECTESYGKLDVAATAIAALHHDNVLPRQELGRGGEVVPLDARHDVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z5</accession>
    <name>A0A7W7T5Z5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="973" mass="104671" checksum="9F62D0B687279FBD" modified="2021-06-02" version="1">MVLRIDVLGEVRAVVGDRVVELGHQRQVCVLVALVVEPGRAVPVDRLVDRVWGDDPPRSARRTLASYVTRLRQVVPDLTITHRAGGYACDLDPAAIDLHRFTRLVAKARTTVDETAGALYAQALDLWRGEPFTGLDVPWLVELRRDLADVRLAAQIDHADVVLRLGGHAGLLPELAARAARHPLDERIAAQLIRALYRDGRTAAALDAFGRTRTALRDELGTDPGAELRELHRRLLSDSPVPRQLPAPPRVLTGRQAELAALDAAVGDAVTVISGIGGVGKTALALSWAHRNAGRFPDGVLHADLRGFEPSGRPTPPGTALRGFLHALDVPAERMPGDVDAQAALYRTLTADRHMLVLLDNARDTAQVQPLLPGGERCAVLVTSRNRLGGLAATHAVRAVALDVLEPDQAHALFTTRLGASRVDAEPDAAADLLRWCAGLPLAIGIVAARAAAQPNATLASLAEESGLDTLDAGEPNAALRTVFSWSYGALPPDAAVLFGLLGLVPGPDVPLEAAAAMADLPVPRTRSLLGVLEAAHLVAQHVPGRYRMHDLVRLYAAEQGRERDPAALGRLESWYLHSADRAATRLYPIKTRLSVGESCGPIADIPDELSGQRWLEAERNNLIAITAAARGWAASRLADVLRGFFWHRMDATGWRTTAEGGLAAAIACGDDEGQAAALLSLADLRFKLSDHDGAVRYYSRSLEIAGRFGWIRIEAAARSNLAGVHWRRGKPALAADQLMRARDLHARSDNEGGTTTAIANLAIVLRELGRLDEAFELHGQALELDLRLGGQSSMSVTLGEIGQTLHTMGRPVEALSHLERARELMDLTGHRSGLSDVLRNLAAVHLDLGRPAEADRLAREALAEAFETHDRQHQANAHNVLGRVDAVRGDRPAARRHHRTALDLAMSARVRYAAVEGLLGLAVVADDPAEARDHAARAAAMARESDYRLLVDRAAQLLDHEHAVADHPIEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B7</accession>
    <name>A0A7W7T6B7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="30131" checksum="83AA1A64BD885E31" modified="2021-06-02" version="1">MTSTLTVADPARTPGAEFAAIAGAASDAGDLVVPFSTHLPAAFPLFASRPRYPVRHLLKTARVADGPATFVHEPPRGALATAGTSYASTPEAAFAPRLAETPLTDLVARVPAPEGVLDHPELLAQYVDFRVLVRLSVVENQSLLTGTADGAITGLLNLPGTRHTASPHGLEQAVTRAAAEVEETGGSCDGIVAHPFTYWEMVRTGLLGRLQVAGITVSRTRMIPRDSLLLGDFRAAFTLLLPDVAHIALRRESDGDVFEASTRIGLAVHLPQHLMTLSWQADDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M0</accession>
    <name>A0A7W7T6M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22851" checksum="0EAE369D862D2966" modified="2021-06-02" version="1">MDHVDAYCERLGIGLLAEPWNAVSNAAFLVAAVLLWLRYRPRPRSLRALPVLLALVGLASLSFHTFANTITNAADVGFIAVFVLWYLVCFAHWYLGFGWAKSWLVVPAFAVLAAVTLPLANLIPGGSGGYLAPLLALITIAVVAAVRRQPWTDLAAAAVVFVVSLTVRTLDQPLCADWPSGTHYGWHTLNAVVLFLVSRAAIRHAREAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N6</accession>
    <name>A0A7W7T6N6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="387" mass="42183" checksum="A3761998A480142B" modified="2021-06-02" version="1">MSSTAHRDRAADLLARVPLVDGHNDLPWALRDLAAEGEIGEKSIPGDPCRGASRIDLRTLQPALQTDLVRARRGRLGIQFWSVWVPCRLAGDAAVTAVLEQVELVHELVAEYHDELALATTADEAESAFAAGRIASLIGAEGGHSINGSLGVLRALRRLGVRYMTLTHNENTPWADSATDEPVHGGLTDFGREVVREMNRIGMLVDLSHVAPSTMRDALDVSTKPIVFTHSSCRAVADHPRNVPDDVLARLSGNGGVCMVTFVPRFVSQRLAEWDDELKDAMTAAGENHNDLEVRERFLATWRSATPPPRVTLDDVVAHVEHAREVAGIDHIGIGGDYDGTRELPEGLEDVSTYPDLFGALLERGWSEDECAKLAGRNALRVLRDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T722</accession>
    <name>A0A7W7T722_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7415" checksum="E42A2614EC6748E9" modified="2021-06-02" version="1">MEYRWRYQDAQGREVDGPQETFADQGEAEDWFNGVWQDLRASGVDRVTLLRDESEVYGPMSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E8</accession>
    <name>A0A7W7T7E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase RecQ</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="236"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="691" mass="74278" checksum="BA9021735F4B97C5" modified="2021-06-02" version="1">MDDTALRDLAEERLRALAGPHAVLREDQWKAIRTLVADRGRALVVQRTGWGKSAVYFVATALLRSLGGGPTVIVSPLLALMRNQVAAAARAGVHAATINSANPDEWQDVRDRVVAGEVDVLLVSPERLNNPDFRDAVLPSLTASAGLLVVDEAHCISDWGHDFRPDYRRLRTLLAELPAGVPVLATTATANDRVVRDVADQLGVGPETVVLRGPLDRESLRLSTVRLPSAEARLGWLAERLAELPGSGIVYTLTVAAADDVAAFLRDRGYAVAAYSGRTDPAERERAEEDLLANRVKALVATSALGMGFDKPDLGFVVHLGAPPSPIAYYQQIGRAGRGVERAEVLLLPGREDRDIWAYFASLAFPPERVVRQVLDALADAGRVLSTAALEPLVELSRTRLEVVLKVLDVDGAVRRVRGGWESTGQEWRYDAERYARIDAARRAEQQAVLDYLDTTGCRMEFLLRQLDDPHATPCGRCDNCTGRHVSAEVSEVAAAAARERLDRPGVEIAPRRMWPTGMAAVGVGLSGKIPAGEVVEVGRALGRLTDIGWGNRLRTLFGEADQDVPEDVFAACVKVLAAWGWAERPVGVVTVGSRSRPELVEGLGQRISALGRLPLLGRVWLGEGAHRANSAQRLAGLAGAVDAPDLSTVEGPVLLVDDRVDTGWTMTVAGRALRRAGAPAVLPFALAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I7</accession>
    <name>A0A7W7T7I7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isopentenyl diphosphate isomerase/L-lactate dehydrogenase-like FMN-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="7930" checksum="CD4F3B25553DA86A" modified="2021-06-02" version="1">MSYTLVLRTAEFDRAVVAAGYSSVDDFAGRVGLPVEEVGVVRGGGEPSTEFIAEALVALAPVTFANLFEIVDRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L2</accession>
    <name>A0A7W7T7L2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="44595" checksum="DD74B192A9F71961" modified="2021-06-02" version="1">MSGFALITMGIGADKIYGWFKDGRGPESTTDPGYEAWGTIASGHGEVGDLINQAVRDSGASWEGTAADQARANTTPLASWSDTASDSAQKASFSTAKISGSFRHARDSVEQPVDVPDKPWYNDAVPWDTDYDDAVDQSKEVNNRNMQVLSSYGSEANNASSELPTFQSPTEVGANVDQDDSKVDKPNDWNGHDSSVGTGDTGTGRNGNSSTGTTGTSWSPPPTPTGTGTGTGTGTGIDGGGSTTNPSNDGGDGTRRPWTPDPTPIPPPNDPRNPNNPNLPGGYDPRQPYDPRNPNDPRNPNNPNNRPPGVRPPGTGGLNPLTGRGGGPGGGPGGGPGGLGGLKAPGLGGGPGGFGPGAGGLGPGGAAGSLSPGDRSGVGGFGSNAGGGAYGGAAGGRGAAGAAGMGGMGGGAGQGQGEEDKEHKSASYLQETEDIFGDGTMVAPPVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Q2</accession>
    <name>A0A7W7T7Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18211" checksum="33B65C2D8B1635B5" modified="2021-06-02" version="1">MTALLSSFFHRVGARGRWLDLATEFCWERIEALDESHPYEVNACARFLDHVPDRPRAGVASARLGELVRQRGLVDLGDGAVHDGYAVGETHTATHYAPRPDCLARQWFSDGEMGAALDRLVAARQDDGGWTFPWAVWTPITEFEWRGIVTVDALATLRAYGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y2</accession>
    <name>A0A7W7T7Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="80"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="717" mass="77693" checksum="FEAD1888D2572F9D" modified="2021-06-02" version="1">MTGADAREPAGRPTKVRNDLSGGVVGASVQSGSIEGGVHVHLDRDGVVPVPRQLPAPPAWFTGRDRELDRLEEVRRRRDPDRPTVVVLTGPGGVGKTALSLRWANSLAPHYADGQLFVDLNGFSDDTPTDPGEAASSFLRALGVPATAVPAHLAEQTALYRTVTADRSLIVVLDNALSAAQVKVLVPSSPAGLVVVTSRSKLTGLLGEGAHIVEVGPLAPSSAFTLLARSVGEDRVTRERDRAEELVSLCGGLPIAVRVAAARLLVRSRWSVGRVHDELVDEQSRLNRLSPDGELSVRATFDLSYRMLEPRAATLYRRLSLHPHGDFGPEVASSVLDDGQDTEPLLDALLDASLIEERAENRYVLHDLLRLHARHRLDEDEPPGEPGRVLRRIAEWYLATAMRADKLLTPHRRRLPYGFATPAPSVRSFADRAEALEWLEDERVNLMAAGRIALEHDLAELSWHLSDVLWPLFLLRKHHRDRLEADRRGVVAARRWGNTFAEADMLRRLGRALTTARDHHEAERCLDRAIDLWRGLDDDHGVSTTRELLGLLYRDTGRLDEAHDQFTAVVEASEALDAPRPVGLALINLALVLIDLGRAADALPHLDRAARLFATLDPPDPYNAARVTVTSAAAQLGAGDPVTASDTARKASAQMDALGSVPGLAEAHRVLGEAVLRTGGPAAAHDHLAAAERLFRSIGSVAADAVRERLDALGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T804</accession>
    <name>A0A7W7T804_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21016" checksum="0F7E1C1CBB6E1DAC" modified="2021-06-02" version="1">MPIRTNRGRAAVYRRLWGWPLRSPRHLAVTIIGFAVLIAVVSVVVPNAIESKTTAAGTTSAPPTTGAGQVGVLPASGATTTPPPTKAASPTSAPPTAAVAPEAQIVAENWAEAFVSFKPGTTKEAWLKGLESYTSTEFFPQLASIDPANAPTVIKGVVKSTKSFTDSVEFEVPLESGKLLLTVVKRPEGWRVHRYDKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T813</accession>
    <name>A0A7W7T813_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33836" checksum="DD90036DB942BA3E" modified="2021-06-02" version="1">MTFDLVASPALSRFTVDRSEPLRGDAERLAQGWPKARVIEVDAGGRTLVADGGSRLVHREATGYGDVPHEHAVFLGEQDGVAYWAVPRADDTTEALAPGRVWDRPAAGAEPTWLDLRSCGALLDDMGAGLFTTAVALFHWHRTARFCARCGAGSDAVKSGWARICGACGHEEYPRTDSAVICLVHDGADRVLLARGEGWPAGRYSVLAGFVEAGESLEACVAREILEEVGVAVRDVRYLGSQPWPFPRSLMIGFEAVADPDEPLRPAVGEIAQAKWVTRADVRQAFERPGSVPDLLLAPGASIAYRMIQSWAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T825</accession>
    <name>A0A7W7T825_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylated DNA nucleotide flippase Atl1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11908" checksum="1CEEEAED752155CA" modified="2021-06-02" version="1">MEEELHEQVREIVKSIPAGRVATYGDVADLAKAPSPRMVGQVLNGDGHDLPWHRVLRANGTCAPHIAEEQLQRLRAEGVIDDGGKVDLRKYRWEEAVKDEDGPPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T872</accession>
    <name>A0A7W7T872_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="16718" checksum="4A8E10D379504C75" modified="2021-06-02" version="1">MNDQLPSVMEIRVLLEDLTGRAVDVSPHDSPGWSGKPPVTAVLVCNDMKVGVVVAFELPLAASLGAVLGLIPVGGAEACVEDGELSKMIEDNLFEVCNVLTAVFNKGGGRHVRLHALHSKPSEVPSDITAQLNALGSRLDLTVQVNGYLPGKFSIVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T887</accession>
    <name>A0A7W7T887_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="381"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="601" mass="63886" checksum="1D90929B550515DC" modified="2021-06-02" version="1">MHPPSGDRGRGFTLSVDLAGLFAAVLDLAAADAPFDDAADAVARHLLDLPGVVDAFVTAAGPPRAGSREVVDPLGTRAVRVVFDDHAEAHDRARLDAVLTLVEAAAGSRTMPLQRMRAGSRRSGSVVATIDAAGRWYAAPETVAHVLGHVRTGTDLAGLRSLVHPDDLEGLQRTFRHILAHPNSQSEVDIRAKHADGHWVVLRVAMINLLDVPTVGAVVVHGHDVTAVRAAERVVAEERRRIREVVSRLTGGVVLDDGERVILANSATARMLGRAPAPNTPIADFLDLVADQCHDPASAQVLLAQLSGTGVERRGVPFQLTGGRTLVCDVLPLGCGDETVPQGVLWYLRDTTEETTARSELEEHNRALTAAAEIKSRFVAVVSHELRTPLTAIHSFGELLLDESEGMNPEHVDGLAAINRNAARLLRLVDDLLLLTRLEALQLPLHRHQVDVPELVDRVRQDQSGSAADRGVALRVEVEPGPNLHADPLRLAQVLDNLVGNAIKFTAAGGEVVIRAVPEGDGWTISVADTGIGIPEHELPRLFEAFARASNAASAGLPGSGLGLTICAQIVELHGGRLTVDSTEGEGTTVRVRLPGDGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D6</accession>
    <name>A0A7W7T8D6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aspS</name>
        <name evidence="9" type="ORF">F4559_004529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="138"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="534"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="593" mass="65247" checksum="9D0F992FEC2B75F2" modified="2021-06-02" version="1">MRTHEAGTLRAEHAGQSVTLTGWVARRRDHGGVIFIDFRDASGVAQVVFREGEMAERAHRLRSEFVVKVVGDVTRRPEGSENADLPTGAIEVYASELEVLNESAPLPFQLDEHLEVGEEARLRHRYLDLRRTGPAKALRLRSEANRIAREVLHAEDFVEVETPTLTRSTPEGARDFVVPARLRPGSWYALPQSPQLFKQLLMVGGLERYYQIARCYRDEDFRADRQPEFTQLDIEMSFVDQDDVIALSEKIIGALWKNLAGHDLDGPIRRISYADAIAKYGSDKPDLRFGLELTELTSYFKDTPFRVFQAPYVGAVVMPGGADQPRRTLDAWQEWAKQRGSKGLAYVLVAEDGTLGGPVAKNLSDAEREGLAKAVGANPGDCVFFGAGDPDSARALLGAARVEIAHRVGLIEEGSWSFVWVVDFPMFEAVDKIGDDVAVGSGKWTALHHAFTSPTPEWIDRLDESPGEALAYAYDIVCNGNEIGGGSIRIHRADVQRKVFEIMGLGAEEAQEKFGFLLEAFKYGAPPHGGIAFGWDRIAMLIGGYDSIREVIAFPKSGGGFDPLTSAPAPITALQRKEAGVDAKPAEKQTADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Q9</accession>
    <name>A0A7W7T8Q9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiol reductant ABC exporter CydD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="41"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="306"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="345"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="505" mass="53705" checksum="2E7D2CC37E4CAA91" modified="2021-06-02" version="1">MRHADRRYVLVLGLLGVLTAAVVLVQAEVLVGALTGAPDWWALIAVVAARALVVTGSRIVTQREAATVKALLRKRLLRDAAARRGARAGEVTTLVVRGLDAVEPYFAGYLPQLVVAVTVPVAVLVRLSFADLGSALPIVATLPLIPVFAALVGKHTRDRTRRQWDALVTLGGHFLDVVRGSGTLRMFGRARAQARTVRAMADAHRAETMRTLRVAFLSALVLELVATLSVALVAVPVGLRLLDGGVTLHVALLVLLLAPEAYLPLRAAGAQFHASAEGLAVLENAVSENAATRPAAATAAGRPPDLRTAEIVFDHVTVHYPDRDAPALADFVLRVRPGERIALVGPSGAGKSTVLGLLLGEVAPTSGRVLVDGVDLRELDRAAWLRQLAWVPQRPTLFPGTVGGNIALGGPGDVREAASAVGVAHLLDERHPLSSGERQRVAVARALVRPDARLLLLDEPTARLDNGTEETVLRAAREWSRTRTALLVAHRPALLDVVDRIVEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y4</accession>
    <name>A0A7W7T8Y4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031298614" evidence="1">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11866" checksum="65CE98D6A955FD4B" modified="2021-06-02" version="1">MRALLVLVAALVLPGTAVAADADAKGQFRYVYSTDLGDVETGSLRDPEIGTCLAFPGLGDERLARSTRNQTDATAIVYREDDCQGDYYVLEPREKRIHDSDARSVRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y6</accession>
    <name>A0A7W7T8Y6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15610" checksum="B94C8381E15608EB" modified="2021-06-02" version="1">MPESDPEPGLASLLRLAVVRLTRRLRAQRINSTISLTQVSALSTLHKCGPLTPGELAAKEGVQPPSMTRVIAALEEFGFATRRPHPTDGRQAIVETTDTGRAYIKEEVSAREAWLDKRLAELTPEERAVLSRAAGIIDRMAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H6</accession>
    <name>A0A7W7T9H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hippurate hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.32" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047980">
        <property type="term" value="F:hippurate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="206"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="43407" checksum="95B07B19C63B6E2B" modified="2021-06-02" version="1">MSTTLPNTRTTTPEPRFTGLAEAARALQPRTVALRRQVHRHPEQGLTLPTTQAAIRHALNGLPLEITEGTSTTSLTAVLRGAKPGPTVLLRGDMDALPLQEETGLDFASEVDGTMHACGHDTHVAMLASAARLLSDRRDELAGQVVFMFQPGEEGHHGAKFMLDEGVLDAAGTPVERALALHISSKLQSGVVTSRPGPMMASADEFFVTVTGQGGHGGMPHNALDPVPAAAALIGAFQTLVARRVNAHHPAIVSVTRLAAGTTTNIIPEKAYLDGTVRTLSEDTRKFVLAELETIATHIAAAHGCRAEVRIKPGYPVTINDDTVGTHVLDVTATALGARWAVPMADPLMGAEDWSYVLQRVPGALAFLGACPPGVDIEKAEANHSSKVLFDESAMEHGVAVYAAFALDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H9</accession>
    <name>A0A7W7T9H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021365">
        <property type="entry name" value="DUF2891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11199">
        <property type="entry name" value="DUF2891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="37450" checksum="A8747525689CC53C" modified="2021-06-02" version="1">MPEKRLDDATAGRLLAVAVENVRREYPVHWVHVVSADGGLVPQRELHPVFAGSFDWHSCVHQTWQIVRLLRLWPTLAGAEDASDTLDSLITLDGSRTEAAFFDGPQGSYWERPYGWAWLLTLAAELHTWESPWAAELEPLTSTIRDRFRSWIAGARLPVRTGTHGNTAFAAGLVLDAARAVDDVDLAAACESAALRWYSGDRGYGGFEPDAPDFLSPILTEADLMRRVLPADDFVSWFEELLPDLGGDRWRVLRSPVEVEDASDPYGAHLVGLALSRAWQWRAIGEALPPDHRFRTPASDAAAAHADAGWRYVFDQGYATEHWVGSYALYLGVGAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N8</accession>
    <name>A0A7W7T9N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006487</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29451" checksum="83CFEFCDB5A76EF8" modified="2021-06-02" version="1">MVSIDVWNASVDFPIFDAKSRSLKKLALGKVGGKIGSEGRVPIIEALHDITLSLKHGDRVGLVGHNGAGKSTLLRLLSGIYEPTRGSARISGKVAPVFDLGVGMDPEISGYENIMIRGLFLGMSRKEMEKRVDDIAEFTELGDYLSMPLRTYSTGMRVRLALGVVTSIDPEILLLDEGIGAVDAAFMAKARDRLNDLVKRSGILVFASHSDEFLVELCNSAIWMDEGRVKMFGGLREVVTTYKGRDPYEHLDAETLARIGQTHALSGNGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y6</accession>
    <name>A0A7W7T9Y6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14733" checksum="804D3B8048FFC589" modified="2021-06-02" version="1">MTPARTWSPKRAIVVVDAVLVALALVAVPFTTDATGRVLLVVLAALGALWTAHFAVRRLTADDTGLTLGTLTGAKHLPWHEVKIKLVHTRRLGREVATLELDWARGDDEKLYVLTPFDLGTDPVEVTDVLHALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA27</accession>
    <name>A0A7W7TA27_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="13403" checksum="FAFBFE3211BBB081" modified="2021-06-02" version="1">MDEILGQVLRNAVWERLDLLTELANEADAPSLLSVARSELPRLTEGWRALLAAHEPDEKGNCPECSGRWRQQKSPCSVWRAAYEHLVAGGLAPRPARHLRSAPVTPPVTRSRRAAAVLRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH3</accession>
    <name>A0A7W7TAH3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030518416" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="61"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="602" mass="62587" checksum="10774682FD73C9A5" modified="2021-06-02" version="1">MTRRRIAVLVAGVVLFGGVVAVLRTAGVDTPATPTSTSVPPPTSLAPFAAEGVLVPRPGEAPHTLDVLTLRPGPRRIQASWTGTAPGYEVSWGRDGRLDHTALVARTTAQIDGLDDGVEYTVRVREVDAFGQRSEPMQDKATPHTQDVGSLVFVDRFDQPDAPDPRRWRFTSRPNCARATPGRGDDGARLVISGSCAAAPAALRSRTPFVLRDADDLGRFVVETDGPGPDGELFVDLVPGPFSVLVGESLPPNALRLRVASGGGTSSVSVLTPAGTPTTRVRPVPTLEPGLTHRWELVLRRDGTTVLLDGTPVATSPAVPAWREATALLSVAGPTGQRVNVSLIGFDGVTAQAPELVPPPPIRVKVAAEAPPPGDLKPIPGLTGGQLRLSILHSDPAPTPPPFEAVIGGVRVPLRPAVADTPWAADTAYAVIADVPAEALRWDGAALHVTVLSAQRLQATNVDLEPTGTPGTPPDRGDVTPLGGDKTLARATGTVLDASGNPLPENTPVHRGRLVFDLVLDGVASQRGAGIAGLAGFTVRLDGDRVASVPTALGGPAVAGRYRLAVDTQGLAEGPHMIEVKLFGTSSDTVPTSAFVPFFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT62</accession>
    <name>A0A7W7WT62_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">F4559_000255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="21219" checksum="EDCF9BF17987FE55" modified="2021-06-02" version="1">MTTAEKTTPRLKTRYREEIVAELRKQFEYANVMQIPGVVKVVVNMGVGDAARDGKLIEGAVRDLSIITGQRPEVRKARKSIAQFKLREGMPIGARVTLRGDRMWEFLDRLLNIALPRIRDFRGLSGKQFDGNGNYTFGLNEQSMFHEIDPDAIDRPRGMDITVVTTATNDEEGRALLKHLGFPFREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT81</accession>
    <name>A0A7W7WT81_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11157" checksum="D4280D9DAD0858AB" modified="2021-06-02" version="1">MAGGYGTGTEELVGAATDIVSTDEHVQGILRSLRGTVDTVGASWKGQAATAFQNLINRFDEDARKLQEALRAIAEQMSGSADIYRRQEEEQNQSMGGLLGRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTG3</accession>
    <name>A0A7W7WTG3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_000031</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="13">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4962672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40482" checksum="86F7ED40854A4E97" modified="2021-06-02" version="1">MDPAPSLKIGPYAVDPAVVLAPMAGITNVAFRQLCREFGSADSLYVCEMITARAVVERDAKTMEMITFGEGERPRSMQLYGVDPKSMAEAVRIVVGEDRADHVDMNFGCPVPKVTRKGGGAALPYKRRLFRQIVRAAVRAAEPAGVPVTVKFRIGIDDEHLTYLDAGRIAADEGAQAVALHARTAAQRYSGEADWTAIARLKEAVTNVPVLGNGDIFSAQDALDMVAKTGCDGVVVGRGCLGRPWLFGELQAAFRGQPPPPPPKLGKVAEILGRHGALLADHLGEEKGVRDLRKHMAWYLKGFPVGSELRRSLAMVGTLAELDDLLGRLDHDAESPVDAEGPRGRQGSPAKVVLPEGWLDDPEDDTVPLGADVMHSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR0</accession>
    <name>A0A7W7WTR0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">F4559_000346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="30006" checksum="C3DAC9ECED4104DA" modified="2021-06-02" version="1">MAIFITKDSKVIVQGITGAEGTKHTKRMLASGTNIVGGVNPRKAGQKVDFDGHVLPVFGTVKEAIEATGADVTVIFVPPAFAKAAVIEAIDSGIGLAVVITEGIPVHDTAAFWAHAVATGNKTRIIGPNCPGLISPGQSNAGIIPADITGPGKIGLVSKSGTLTYQMMYELRDFGFSTAIGIGGDPIIGTTHIDALAAFEADPDTVAIVMIGEIGGDAEERAAAYVKANVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSAGTAQAKKEALEAAGVKVGKTPSETAALMREIMKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU9</accession>
    <name>A0A7W7WTU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="26952" checksum="1B1AF4AAC82B82D0" modified="2021-06-02" version="1">MNGRAVPLPPGAVSLRKVVTSPPVAGRVRLDKAPVARTSLRGRVIAVIGLAGSGRSTVAAQTAAAFAGQGLDEVVSVDASPWPGSSRSPVDPGRAWGWRRLAALPDGSGPTCVPVVHGVWRLGGCEAFDTVGPSEVLRVLDMCRERMAIVDCPAGGAATARACVAVADAVVAVCRADPVDLRNMARLLGLLAGDARRDLPAVVAVVAHRPGRWPRAAAVAEAGVAEVAGAVVRMPFRRELSRTGTVVGPALAGVDVAAAVSLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVG7</accession>
    <name>A0A7W7WVG7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA mutase cobalamin-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26126" checksum="A4CAFA4831BB3760" modified="2021-06-02" version="1">MINPGVASVTFRGRPVGEVAALAADAGLSLVEWAGDVHVPAGDLYAAVRAAEATRAHGLAVGTYGSYYKAGQGEDVTPVLDSAQELGAPRVRVWGGVKGSADTTPAERAAVTDDLRRCVDLAAERGLAVLVEHHVESLTDTLDSARRLLADVPALVPHWQPRESPDVEECLAEVRALRPVSVHAFSWGDDGFTERLPLGAREDLWRPLLSGYEGDVLLEFVPDDSPEAFRRDAATLLAWSEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM6</accession>
    <name>A0A7W7WVM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9577" checksum="0196D02736EA5115" modified="2021-06-02" version="1">MTITQRNSMDDTTQDAEHPIVDVDATTQAVGYGDLTLLSLSECFRPVAKSLCGLSRRNVGFAFLSGVEEGVRRCVEKSADGSRGVWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV1</accession>
    <name>A0A7W7WVV1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="35" mass="3737" checksum="FCB49B77C393A672" modified="2021-06-02" version="1">MTRVCRGESQPGIGFVVGALSGLAPLKFEDLFEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW32</accession>
    <name>A0A7W7WW32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="35" mass="3813" checksum="6E29C36D432DAEE8" modified="2021-06-02" version="1">MAVNGYVPVPGTVNRIGILVAVVGRTLRKFLDEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW49</accession>
    <name>A0A7W7WW49_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="29203" checksum="CA86096EB894D80C" modified="2021-06-02" version="1">MRLDGRSWRVRIDKVRLGADEYRVVRPAAVIKHAALHESRFGANLSVDKDAAVEIAAAWWLAARSPRTLIHLPLKASPATCGGWTGERRLDLVLLHHSLGFRPAHWKQVRARLSAGRPHKITLPADALPVFDDEHHVRASHKDNLDRLHWDIAADTMFVVGSRAAYENEAGKIRGLVEDCPSHLAHDPTTHCCAEIDLDPCRPHHYAGLHVECCDDHYLRTGSPATRRSSSASPSTPSSPSTSATSRSVPEPAFSTMAAPRSSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW74</accession>
    <name>A0A7W7WW74_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="35050" checksum="034F8C0499BCBADC" modified="2021-06-02" version="1">MGYGRWDDDTYKAARTFRAAQGIDDFGYTADMRHQPREEWRADPLLDPYRVTARECRDSADHADSTPIAVLFDVTGSMGRVPRIMQGKLGRLHGLLRHKGYLADPQILFGGIGDADSDRVPLQIGQFESDNRMDEQLRAMFLEGGGGGQKSESYELAAYFMARHVATDAWEKRRRKGYLFLIGDELNKHRLEARHIRRVIGDAVEPDIDPRSVYRELATRWHVYYILPRQSSYYDDPEIAEHWRDLLGQNFMRLDDPGAVCELIATTIGLEEQVVDLDQALVDLAEVGSKAESKAVGRALAAGGRRAIGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW89</accession>
    <name>A0A7W7WW89_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031215347" evidence="2">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="40917" checksum="1DCF13D433401A49" modified="2021-06-02" version="1">MIKYLTVAVVSTSLIGFGVPASARPGRGDLLSAMPITGLSVAEVTALLARQAIDTGAVRHGVDAYRLEYRTAGPDGRPITASGAVVLPRDGGPARPTVAFQHGTIAAKAEAGSVGPDTNRTAPITFAAAGYTTVAPDYLGLGTGEGTHPYLDLPTETGASVDLLRAADTFVRRAGRTLDRRVLVAGFSQGGPAAMALGRALRDHPRFAPRAVASISGVHDLFGTQFPAALDGTVTPKLATISTAYYLVAANRLHHLYDRASRAFRAPYDAIVENLFDGLHSGPEIAASLPATPADLLTGWAVGQLRRPTGPMVRAARATDGSCVGWDPGVPVRLYAGTEGDELVPLGNSTRCRAEFLEHGADAPIVDLGPVNHNTSAKRAYPLVLEFFAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB7</accession>
    <name>A0A7W7WWB7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="45"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="516" mass="53496" checksum="C5B0C8B739A36EA1" modified="2021-06-02" version="1">MTTLLVGGRVHTPASPDATAMAVTDGVVVWVGQDAVGRALHPDAEVVDLDGAFVAPAFVDAHVHATSAGLLLTGLDLTDCPSPQALLDAVRTFDGPLVWGHGWDETRWSGRVPTRTELDAAAGGRVVYLSRVDVHSALASTALLDRAPGARTADGWSEDGPLTRAAHHYARAVAKDAIPVDQRRAAQRAFLDHALSRGVAAVHECAGPEISSVADLADLLAITDGPRVTGYWGDRARIALPVAGYAGDLFVDGALGSRTAALCAPYADDPATSGARYLDADTIADHLVACTEAGLQAGFHVIGDAAVAEVVTGFERAAAKVGTPALAARRHRLEHLEMITAGQAATLASYGVVASVQPLFDHEWGGPDGMYAQRLGVDRGTALNPFSRLAAAGLILAFGSDAPVTPVDPWATIRAAVHHRTEGHGISARAAFTAHTRGGWRAAGVDDGLTGTLRPGASATYAVWEAGELEVAAPDARVQRWSTDPRSGVAPLPALAGPAPKCLRTVLDGRTLWAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWC3</accession>
    <name>A0A7W7WWC3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031430319" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19263" checksum="8AC8F24D9AFB45D3" modified="2021-06-02" version="1">MRAVVIAVLTLFVLTPVASARAEALTLVHAERVPLGAGILTASFSAWPIRAGRSLDFTFEPDGGIDGHTGALRAIAPSGEAHALGIVGLDGNVDMKLPRHPRARDVWGLDVVALPEEGLWRFEFTVDGAATATMPVPVGPAPGPPPAVSWAVGMAPWAVALVVLSRRWWRVRGRWDRGWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWC7</accession>
    <name>A0A7W7WWC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="34499" checksum="8142CE86F1C8C119" modified="2021-06-02" version="1">MFRPVPVPALPPSTALADLTATGDDHAWLAGTTGVFTSRPSAPLILRWTGTAWRVEDLPGIAAAASLAGISATGPDDVWAVGNSAGRPLVLHWDGTRWHLRTPPAIPWAKAVLALAPDDVHVVGAGPDVLHWDGTDWHRTAVLSSDREGLQTVTATGPDDIWAGGAGLAGVGPATYEYPVLVRRTATGWHEVRGPHVDHGHVTRLAVATPEDVWLAHVHGSDGLAVHRWDGERWRPAPLPAESGRLSLHGVAAGWTWGVRTTRHSFETHPAFHRWTGTAWQDVPLPDSLARTPASHVGLATAGDTTWAYLKTAAGVHVLRHTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM2</accession>
    <name>A0A7W7WWM2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20668" checksum="DDE393667BE4F5E5" modified="2021-06-02" version="1">MSDRPALTGPDGLLKLFTENVPKTALAEETTGHLGREKNRAEPGRESTSVRNGSRTETVISDAAGEVGIGVIRDRDGTFEPRIVKKWRRRLAEVDGIVLSLYARGVTTGEISAPSAGSTAPRGRGSRSRASPARSSRRWATGPPRLPDAVCAAVFLDAIVVETRGGWFVDRPVHAAMPGTSSCRSWTTTSRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR2</accession>
    <name>A0A7W7WWR2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7020" checksum="ECC07FA82FACF818" modified="2021-06-02" version="1">MQRGGLPDDAVVLSGEELADLQDRLFQLRCAAEDIATAATDGTGGAELLRLATELAHTARGLERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWS9</accession>
    <name>A0A7W7WWS9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5376" checksum="6A76347C4730AADE" modified="2021-06-02" version="1">MVQQVAEDVPTSYRLRGVHDQAVTVAGRADHLLDFPLLRAGVRSARPCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU2</accession>
    <name>A0A7W7WWU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5743" checksum="C2C7A47E2731A55D" modified="2021-06-02" version="1">MSHSTGVQSFSRPERFFPAGHTCAQYRVIGRFCECVHGHVLRLSTHRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY1</accession>
    <name>A0A7W7WWY1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="33431" checksum="666E143FACF03739" modified="2021-06-02" version="1">MTTIGVTVLGPPGSGRTTLMAAMSAWSDGRLSTSDPGGGPHAAWRALTAHGLLPREGAPVHDLVLRDGDEVVAVLRCAEVSPADPADPAAVARVAASDAVHLVLDGGLLAAGPPDGLFEYMTALVRRALDVRRGVGRPAFPVVVLISKTDLIVGAADAAGVSHEERLAEVVEAVPGLLPVVRDEDVTAMVCPVQVGWFGAAREARVDPARVHPHGLDQAVVFTAGYHLAQEESRCGAELRALAAAVEVRQDELAGLGRHRRGRRRELESAVSAAVAGYARVEELRKTLRRRTDVLSAALAGHVPVLRHGHPINTGAPRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX28</accession>
    <name>A0A7W7WX28_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU (Regulator of sigma subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="308"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="539" mass="55843" checksum="B34B908465FF6A41" modified="2021-06-02" version="1">MVLDDESADAVEAPTATRQAPVDPVPAARERTVDLLDAFAVAVVVVDANGVVLQATAEALRLLPRLVVGMPLERFPHDGVEVGLGDRIVVGTRRALPDGTTAWQFRDVTAQRAREDALLAERARSRFLARAGSRLGLSLNPARSARAVVELAGELAFAATVVLPGGEYVHGERDAALRVGRWTRESLPVALVEAMDGTAGGVERHPADLFAAGRWLPHVDTSRVAEAVTVPLPGTDLPGPVLVLWRPDTTSDTASGTGSDIEDPHGVVLAEFAARAGMALSTAEVHARQAHTAAVLKENLLPGPLPEVDGLAFGAEYRPATGIGSLGGDFYEVVPTADGTSFVFGDVVGTGVEAAVTSGVVRQSLGALRRVAVDAVRSLAVLNESLLAEAPGDRRRFATVVLGLARPLPGGGARLSLTGGGHLAPLVLRASGAVEFVEVGGMLVGAVADATFRSAEIDLAPGETCVLYSDGVTEARGGVDGTTLFGQERLAALMADCARMPAVAVAERVALGAQQWIGGAEHDDLTVLAVRATPRKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB9</accession>
    <name>A0A7W7WXB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040547">
        <property type="entry name" value="CdiI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18616">
        <property type="entry name" value="CdiI_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14305" checksum="C3819E9273351EE7" modified="2021-06-02" version="1">MSDKLSIEELDGERWPEPARDAPREIAVLHALRRKPVRKLTAGDLRLLLLRDVGVEHVLPRAVDLLRVDPLVNGGHYDGDLLFAVVTRDHAVWTRLPEIAAVLRTVVTEAGLPARLHDDVDAFLDATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXU4</accession>
    <name>A0A7W7WXU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33570" checksum="11AB14C48CF76149" modified="2021-06-02" version="1">MLSFITKRLLSGILLLVVVMTGTFFLAHLVIGDPSYGLLGASATEAQRAALGAKIGIDRPLTTQFVDWVSHAITGDFGVSWRSFTPIGDQLAQRVPITLSVVFFATLLSAILGVAVGIACGLRPGSVLDRVLKSASVILFALPGFWMALVLVTWFGVQLKWFPTFGYVSPEISVGKWLVSITLPSVSLAIGAIVMIAEQLRNSVIQVNNQDFVRTLRARGLPRGRVTRHVLRNASPAALTILALMFVGLIGGAVVVETIFNLNGIGTWTQSAAQIGDIPALLGLTAISIVFVVVINFLLDLVLGWVNPKVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW0</accession>
    <name>A0A7W7WXW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21425" checksum="A12C9BA0ACB5DC7F" modified="2021-06-02" version="1">MSDLTQGARTRAGLVEAAIELFDRHGYDNTSLDAVCRRVSVTKGALYRHFPSKQALAAAVVEEHFRRWYEVRAEIEGTGVSPLTTLVDVTHRMGCLTRTDRTVRVGVRLLFTSELYEMLAGTHFASVAVMVRDLLTRAAAAGEIPPGLDTREEADGITSAIVGAQALSLVTGSEGYPLRSLWRHKVHDFQLTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY04</accession>
    <name>A0A7W7WY04_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of protease activity HflC (Stomatin/prohibitin superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="74"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32876" checksum="FA1464360ED97F51" modified="2021-06-02" version="1">MSAATDVVRMPVPPVREREAIGLPGISAFFIGFFALIAGVALMVTPIVRNPDEPNLTVAVAGLLIVIGGVIGLRGLFTVAPGEARVLQFLGRYTGTVRKDGLRWANPFSTRAKVSTRIRNHETATLKVNDADGNPIEIAAVVVWQVDDTAKAMFAVDDFVRFVGIQAETAVRHIATSYPYDNHDEAGLSLRENADEITEKLSLEIAARVQAAGVHVIESRLTHLAYAPEIAHAMLQRQQAGAVVAARARIVEGAVGMVELALAKLAEQDVVELDEERKAAMVSNLLVVLCGDRSTQPVVNTGSLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY88</accession>
    <name>A0A7W7WY88_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="12761" checksum="DF48AC28B7B1B4AC" modified="2021-06-02" version="1">MSRGTVVVATAAVLWCVFVIATTYLPGVPAFALLTVYLPGFLVVPVFVATLLRARSQAIFCLAHVPKPLLVGGFLVALGGWLFSCGALRGLPGTETLSAVAGLVIVLHVAFGLIAIGMVRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD3</accession>
    <name>A0A7W7WYD3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ORF">F4559_005778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="33134" checksum="08918096B6ECA45A" modified="2021-06-02" version="1">MSTENTSGAYGVGLATVTPSGTVLDTWFPAPALGATDAGTVRLSAAEIAAELGEDAAKLLGVDAERDVEVVGVRVGIADLSTAPADTYDVYLRLHLLSHRLVRPHGQNLDGVFGLLANVVWTNHGPCAVDGFERTRLRLRSRGAVTVYGIDKFPRMVDYVVPTGVRVADADRVRLGAHLASGTTVMHEGFVNFNAGTLGSSMVEGRISAGVVVGDGSDVGGGASIMGTLSGGGKQVISIGERALIGANGGVGISLGDDTVVEAGLYVTAGTKITTPDGDVVKGAQLSGVSNLLFFRDSTTGVVRVRPRQGTGIELNAALHAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE9</accession>
    <name>A0A7W7WYE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="31437" checksum="D8BBC7131A70AE7A" modified="2021-06-02" version="1">MTLRQFEYLVTVVDEGSFTRAAELLHVTQPALSHQIRALERTVGTPLLDRLPRTVRLTPAGRAWVPHARAALAEARRARTAARRAADLEGGELRLATLYSFTLGGLLPPVLRRWRAEHPDVRVDLIEHRHADELRESMARGDADLAIGPDPVNWAGYREVLGVEEFVVVLPPDFAHDGPIDLCALKETGWVHYATTNGLAEVLDNACRTRGFQPRVAVRTEQTAAAPVLAAAGLGPALVPRGVLPDVFDGTVLRPDPPVRRTLVAYAHRAPDPLTAAFVALLAGAGWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF4</accession>
    <name>A0A7W7WYF4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030675399" description="Histidine kinase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="183"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="248"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="459" mass="48906" checksum="F94331BBDEA682CE" modified="2021-06-02" version="1">MRSRLLGIVLALVVLLLVGLGLPLGRGIAAAAQQELFLDRLTDTNRFASLAQRPLVDGQPSAITEELRRYQEVYGIRVALVDQDRRVLASSADVQVSGDVSARVDVALAGREPTEPDLVLPWDDTELVLAEPVLVDGDVRGAVVTLSPTGKTRRAVVFWWLVLLAGSLLALAVAVFAALPLVRWTLRPVRALDDATGTLLAAVVSGRPVPPVDSSSGPPELRQLARSFDQMAANVSDVLAAQRAFVADASHQLRNPLTALRLRLSNLDGQVSGDALTHQVAALDEADRLNRILDELLALARAGAASVDPVPVDVDRAVADRLSAWQPAAAARGVHLVLDGEPGGTVLAPPRGVEAVLDALLDNALKFTRDDTLVHVDVRRTGQTVVLSVRDEGPGLAPDDLERAFDRFWRAPEHQNVRGSGLGLALVRQIVGRVDGTVHLEAPDPGGLRVVVELPGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ12</accession>
    <name>A0A7W7WZ12_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35967" checksum="2E873FFCC7E86655" modified="2021-06-02" version="1">MALLEVRDLTVVFERKGEQPFTAVDRVSFDVEPGQTVGLVGESGCGKSVTSLAIMGLLPKRGAKVSGSVSYEGTNLLSLSDKEMRDRRGRDLGMVFQDPLSSLNPVIPIGLQVTEVLERHRDMARKKAMVEAADLLDKVGIPDPERRLTEYPHQLSGGMRQRALIAIALACRPRLLIADEPTTALDVTIQAQILALLKELVRDLGTALVMITHDLGVVAGLCDEVNVLYGGRVVEKAQRHELFAQPRHPYTHGLLASIPRLDAPRGEKLVPIKGSVADNIPWTDGCAFAPRCPNALDVCRETTPVQEDLGGGRLLRCHNPVQPASTEEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ35</accession>
    <name>A0A7W7WZ35_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septum_form domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030826851" description="Septum_form domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="3">
        <location>
            <begin position="47"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="343" mass="35549" checksum="823A43A5B80C0B21" modified="2021-06-02" version="1">MVMIGAFVGAFALLGLSAFTSLPLGGGAAGTSHSTTPSVNPAFTAKAGDCLDWKREDLSDLTLVDCAKEHLFEVTDVVDLGPEYAKDAPWPDATGWQQINEKHCAKASLDYLSGKFDPFGKYTVGPLNPSEASWKEGGRTVRCGLQVAGPGGALLRAFGSARAQDQSDVYDATVCLGITPARSVGDPVPCAEPHTFEIVGVVPLPEGDFPKPEKQDEIMSAECARIATEYTGGADLKAKGRIVTWDTRAVESWTAGSRKANCKVGAAPDEGGLVAWTGSVRNPDAPPPTTANPPQTTAVQQSEATGAPLHPSTSATGSAPPTTTSSGRTTTSQPTTTTTEADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ53</accession>
    <name>A0A7W7WZ53_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17350" checksum="4831514FF05DA3E4" modified="2021-06-02" version="1">MARRIAQAGGLFTPADRELAEAAAVLHDVGYAPDVVASGFHPVDGARYLEEQGFPDRLCALVARHSCAHSEAALREVSADLARWEDEKTAVRDALWWADMTTTPDGGLTTVADRIEEIRERYGPDDLVTASIGQARPELAAAVERTEERLRAVGLGQVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ79</accession>
    <name>A0A7W7WZ79_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="40606" checksum="279A7FE4DA3DED1A" modified="2021-06-02" version="1">MAVGFWSYAHRDDESARGGVLRLAAAIAEEYDLLTGRTLEMFVDRDGLAWGDNWKERIDAGLAGATFFIPVVTPRYFNRPECRREFVDFSAQARSLGLEEFILPIRYVPVPDLDVDSPDELKATVARTQYVDWSELRLLDESSGEYRRALHELAARLVDIESRMVEVQREAETSPEGDDDLSTLIDRITRLLPDWHEATVDNRTTSAQFWATFEAYRHNRRRTSDLSALIRFGREIQPLNERWLREARTYSARSIELDPLMTSLLRELADYPEGLSLTGPILDAVEDAHDNIVTSVKRTDKGALGMIEFFGRHARLSPTFKTLHSQSTEIDKLANEGNAIVERWATGQSGLRKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZZ1</accession>
    <name>A0A7W7WZZ1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_006707</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="207"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4969348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="471" mass="51885" checksum="E531E93E93B5AABC" modified="2021-06-02" version="1">MSYPRGRTKLDESGGEFAVALVDDRGMAEPGFERQPPQDLAAEQSVLGGMLLSKDAIADVVEVLAPNDFYRPAHQAVYDCVLDLYGRGEPADPITVSAELERRGELLRVGGAPYLHTLIATVPTAANASYYAEIVAEKAVLRRLVEAGTRIVQLGYNGAEGADVDEVVDRAQAAIYEVTERRTTEDYVVLEELLQPTMDEIDAIASRGGSSLGIPTGFADLDELTNGLHPGQMIIVAARPGVGKSTLGLDFARSCSVKHGLTSAIFSLEMSRTEIVMRMLSAEAKIRLGDMRSGRMSDDDWTRLARRMSEISEAPLFVDDSPNLTMMEIRAKARRLKQRHDLRLVVVDYLQLMSSGKRTESRQQEVSEFSRNLKLIAKELEVPVIAISQLNRGPEQRTDKRPMLSDLRESGSLEQDADMVILINRPDAWERDDPRAGEADLILAKHRAGPTATITVAHQLHYSRFADLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXI0</accession>
    <name>A0A7W7SXI0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-CGNR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19427" checksum="3EF28D2C0BB70B33" modified="2021-06-02" version="1">MTGLAAGWDHAAFAHGRAGDAEHDVELLLAFLNTRDLELGTDVLDDVATWRAWVTERGLGRVGDLAEALSVRDSLRSSLGERRAEPGPPPTAGLIRVDLSHGVPTMSSADAVGAVLGAAARLAVLGSWERFKICQADGCRRAFFDRSRNRSRTWCSMQVCGNREKARNWRERRALSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXW4</accession>
    <name>A0A7W7SXW4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13871" checksum="760396CAC096108D" modified="2021-06-02" version="1">MRIGELARLGGTTTRALRYYESLGLLTARRNSTGQREYDEDDLRLLAEIRSLTGLGFALEDTRPFVECLRDGHSSGDACPASVAVYRRKLAELEECVTRLEAARDRVRAQLEQAERRGRPCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY98</accession>
    <name>A0A7W7SY98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13153" checksum="71CF25BE35433792" modified="2021-06-02" version="1">MDPRARADAALARARARGGHVVTPDNMTSPMDSSATQQIPRTVVEAVDPRTADPETTMVLSARTAAGQFPDQTTPLPRVEPEQRVAPGPIPTVQQVASRPSLSQRLSGGPDQQRPPGLAGRLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYF9</accession>
    <name>A0A7W7SYF9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KipI family sensor histidine kinase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="20497" checksum="144B3E633438F9EA" modified="2021-06-02" version="1">MRLLRCGADGVLVEVSSGREVEAVRRAVRDVAGVVEVVPAARTVLVVGGGAGVRAVLADLDPSDVDEAPAREVVLPVVYDGPDLDLVAATAGITADEVVRLHVEARYRVAFCGFAPGFAYLTGLPDVLHQARLETPRTKVPRGAVGIAGEYTAAYPRATPGGWRLIGRTDAPLFDPDGRAPALLTPGDHVRFEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR9</accession>
    <name>A0A7W7SYR9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="7"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="26047" checksum="9F54661D58A738DF" modified="2021-06-02" version="1">MSKSPSMVMLRRNFTHIARNPTSVFNAVLMPVVVMLMFVYMLGDAFAVGVDYVDYATPGLLLMAVCYGLGSVATSVNSDMTKGIINRFKVMDVPRGAVLTAHVVASVLTNLIAIGAVLGVAFLLGFSPSANVLHWLGVLGVLVLLAVAAGWFTVALGLAAKSPETAGLGAVPLVMLPFFSSAIVPAEKMGPVLREFAEYQPFTSIIETVRGLLAGAPRAGDVAAALAWCVGIALVGYLWARATFTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA7</accession>
    <name>A0A7W7SZA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="631"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="873" mass="94267" checksum="464872C49FF61340" modified="2021-06-02" version="1">MPAATPSDGGSTGAAEKARLLHRRGKKAATADRHPTAILLLKRALAVLDAAQDVDSVVRVEIRTRVQATLAYCLAETTSLDEGAALLDRVRAELAELPDMPLKDELHGLIDHNHAVLLCRVGRIKDGIVLFDSDVRHTERRLAETTGDRTAVVDWLVTSLSNRGNAHGTSGSPSLAVRDLNRAIDLAREYGLHERVGIATHALGNFLQRIGDMPAALRRYEEANRLFTEHEPGLLLRLRLDQAEAMLSVGLADEAGRHLDEVLPEMRRQRILQDHAEAELFRGAAALLEGEVRTARRMAVSAHRRLLRRGSPGWAAIAALMIARVDVQKALDARVPAALPRRVLELSDQLAVLRLADASAQARMLAVRLEVKLGNVDRAAELFAAVPTPRPTSAIDHRMLVRMCRAELALARGDRRAALAQAKAGLTELGRMRDSLGAVELVSGSALHGRELGDFAVRLVLGCGDSPADARRLFTWLERTRAQLYRYDPVESTVDSELRERIAEVRRLSRALLRARLDGAPTSKLEIQYAAAQRDAMRLGWSESPWGKPRPVARPRDVMDRLGDRALISFAASDDSLVAVVVLASGVRMVRLGSAAEVNERARRLHADLNALAPDHLPPPLVEVITASARREAERLDETLLRPLVDLIGDRDLVVVPTGALYVVPWAVLPTCASRPTVVVPSATAWLSTTRADPEEASGVLLVRGPGLVAAEDEIDRLAGYHSDARTLGLPDARVSAVLKALDGVELAHIAAHGEHEPDNALFSRLELIDGALFAHEVGRVRRPPHRVVLSACELALNRIRPGDEPLGFAGALLAGGALTVIAASSKVGDQPSAAAMADFHRNLANGAAPAVALAEAVAVDPFRRPFVCLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZI6</accession>
    <name>A0A7W7SZI6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage terminase large subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005021">
        <property type="entry name" value="Terminase_largesu_Lambdalike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41287">
        <property type="entry name" value="PTHR41287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03354">
        <property type="entry name" value="Terminase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="559" mass="63924" checksum="BBB92FE9AAB0AEA4" modified="2021-06-02" version="1">MALPRCGYVLDDLECRERGDHFCEPRALHAKAFFEEILVHTKGTWARKRFVLSAWQDTEIIAPIFGPVRWSEEFGCYVRVIRIVWIELARKQGKSEILAGIALYMLCADGEEQAEVYGAACDKDQARKVFDVAARMVQLSPVLSKRLVVKQHEKRIVDERTGSYYEVIAADAAGNLGHNPHCIVFDEVLTQKNGALWDSLRTAMGTRTQALMVAATTPGDDPSSWCGGMHDEMQRVADQPERAPHIHVFLRNTPPDADPWDETLWGYANPALGEFLSIQALRDEAVEARNDPSKENSFRQYRLAQWVRQSHRWMPMHLYEDCVGEPWLAPDYRRRELSGRVAWAGFDLAAKFDLVSWCLLVPDGHEVHALWRFWLPESGLAFLDKHNEGKFSRWAREGWLTVTEGDVVDYDRVYTDIETDARDFDIRASDADQWSMAPVIQEIEKRTGVWEIDAYNNTYQRMSPGMTELMALVKARRFRHHGNPVARFCFDAVEVRKAPYDPELIRPDKPERDKSGKRIDAVPSAAMAVSAWKRDPLPETKPTEPGRRIVVSSRRGRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T017</accession>
    <name>A0A7W7T017_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="4781" checksum="DCBE5FD44CD6491A" modified="2021-06-02" version="1">MTRIAFRTGGTTAGHPGAPTASCPTAMVRVSDNPSEAGDRLPVRGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G9</accession>
    <name>A0A7W7T0G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tellurite resistance protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="36195" checksum="AFEA7BDBC912F9E7" modified="2021-06-02" version="1">MAVPAWLWIATIVGLLVLLAVDLVIVDRKPHEVTIGEAGRWVTFYVAVAVAFGLGIWYFAGGTPAGEFFAGYITEYSLSVDNLFIFLIIMTTFKVPAIHQHKVLLIGILMALVMRGVFIALGATMIAQFSWVFYIFGAFLIYTGYKLVRTDHDDESEEFKENAALRVVRKVFPVTDAYHGAKSFLKIDGRRYVTPMFIVMVAIGTTDLLFALDSIPAIFGLTKEPFLVFTANAFALMGLRQLYFLLGGLLSKLVYLSIGLSVILGFIGVKLILEALHTNSLPFLNDGQPLDVPVIGIGLSLSVIVGVLAITTIASLIKVKRDPEAVKQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K6</accession>
    <name>A0A7W7T0K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31165" checksum="D3C6B7A5CC54DA9D" modified="2021-06-02" version="1">MANPFVKAWKYFMAAFSSKIDEHADPKVQIQQAIEEAQRQHQALSQQAAAVIGNQRQLEMKLNRQLGEVEKLQASARQALVLADEARAKGDEARATEFENAATAFATQLVTAEQGIEDLKTLHDQSLQAAAQAKQAVENNAMVLQQKLAERTKLLSQLEQAKMQEQVSSSLRQMTELAAPGNTPSLEEIRDKIEKRYTTALGSAELAQNSVQGRMLEVQRSTTQVAGASRLEQIRASMQGGKVAGEIPGAKPNSAAANIQQEIQQRVQQAQQETQQVQNPPASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L5</accession>
    <name>A0A7W7T0L5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="455"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="789" mass="82897" checksum="108D8FC227DE6CDB" modified="2021-06-02" version="1">MTATPAVAGLATLCASTALASVIAGGLWLVYLAVTIAVVVGVGVLLRSVRIPALVVGLGQLVALLCLLVTIFTRSGILIVLPDPQSITDLGAVLGDAVSEVQTGIPPVPDTPAMRCLVMVAIGLVAVLVDTLAVGAAAPAASGLVLLCVFAVPASLADDMLPMWTFVCGAAGFALLLVVDGRRRHDSWRGRRGGGSPGPTATVVTVTALVIAAVSGGALTLVGTVGRLPGGGDEAGGGSGGLGIDPMTELRGMLDRGETRELFRVRGLPKSEYLRAMTLREYVPGKGWQLGGNLSEGVAANGVVSVQPGDPGTGDVTSIEIEPVTWLDNWLPVYGRPRRFAGVDDNWRWDAGRGMVYSVRARKSEKYTLETALGEPGTDTLRGVTGNPDVDQAYLEAPSVDPEILELAKRITAGARNQFDKAYALHQYFTDGTQGFKYSLETKNDTSTDALTDFVLKGKTGYCEQYASAMAVMARAVGIPSRVALGFTAGFPTDEYQTITTQDAHAWVEVYFPDYGWMTFDPTPLSDGRSVVPPYISGMNPDDEEDDSGTTSTTTTTTTTTASAGTTTTAAPGAADQSGQAQKSDPTPVWHMIIALVALLLAVALWLLVAFGGNRRAPRPPILVGALAATVATATFAVAFVTWWLTVPIVLAAVVAAPAALRVLKRRTRLHTVARLGPDAADAAWAELLAESVDRGTRVPSTETVRIAARRLARTHQLDDAGRNGLRAVVGAIERSWYSATGGADPALPHALDEVRRSLHRNAPLAFRARVLPRSVLHPKAPAEEPERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R5</accession>
    <name>A0A7W7T0R5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase RsbW</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15677" checksum="05D9C26C930A60E7" modified="2021-06-02" version="1">MSVSHQEPQSGESENALAGVELRMSADPTQLSIVRAVAADIAMRQDFDLDSIEDLKLAVDEACSTLISLATRGAVLSAHFVVVDGSVRVSTKVGSRRSAPPDRESFGWRVLSALVDSVTTWVAPQPGEGDYEVHIDLVKRSVGTVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W0</accession>
    <name>A0A7W7T0W0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="36"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16491" checksum="5AB7EC3223FFEC16" modified="2021-06-02" version="1">MAGRGTPATALLDKQRVAYELHAYEHDPRHESYGLEAAEALGITPERVFKTLVAEVDGKLAVGVVPVTGQLDLKALAAALKGKKAKMADVAAAERATGYVAGGISPLGQKKRLPLVLDASAQDHETIYCSAGRRGLEVELAPADLVRLAQAVVAPISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y8</accession>
    <name>A0A7W7T0Y8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="93"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="36080" checksum="45BCDE29BAC9C2CF" modified="2021-06-02" version="1">MREHEKYRDYELDFDHADDLNRRSTRRRVRDDVEPARRGRLTEDAKDRLARLREDAVVDDVPDGADRWSTWGDAERGPKPWPEWLVTDLSAVDRELGIVKTGKEADVFLVERSLPDTAQVCALAAKRYRSNDHRMFHRDAGYLEGRRMRRSREMRAIANRTSFGRNLIAEQWAVAEFAALSRLWSLGAPVPYPVSRAGTELLMEFVGTDGQAAPRLAQLRPDQDGLLDLWRQLVDALGVLASAGLAHGDLSAYNLMVHDGRLVLIDLPQVVDLVANPGGREFLERDVRTIAGWFTAHGLEPELADPAEVTRSLLDIAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D8</accession>
    <name>A0A7W7T1D8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="280"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="54830" checksum="D57D224EBAC05151" modified="2021-06-02" version="1">MTDYRTRWPASRLLIAAVTILIIVSASAITAIAVALADLTEARVEVLDEIGPTRRLVIELEGTLVDQETGVRGFALTANPDFLTPYSNGQDAEKQIEDAARAAIRTARPDLALRLDDIAALSSAWRLEFAEPLIVQVHAAGSPQLVANDTERGKALFDRVRNALSALRGDLNTAFDASRDRLDEVADQVLYLSIGLGALLVVIIAGVAIVLYRILIAPLTGLAAQVRRVSAGDFTHEVDVNGPRETVMLGQDVDTMRTRILRDVEELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLERRYSGQLDERGEQYLRFAVDGAKRMQVLINDLLAFSRVGRITREQTVVDCAELVRQVLDNQSETIERLGAVVEVGELPSVRGEGSLLGGVFGNLIGNALKFHGTEPPLVRVSAQRTGEFWTFTVSDNGIGIEPEYAERVFVIFQRLHHKDDYPGTGIGLAMCRKIVEYHGGTIWLASDREAGTTFEFTLPVVEDVQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T266</accession>
    <name>A0A7W7T266_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24411" checksum="D53BF664A9DE3DCD" modified="2021-06-02" version="1">MEAKMHVWYLEEPEYARHERRRGRRFAYTSLVPERTALIVVDMVPFFVAGSPYCMGILPNIDRLATVVRDAGGTVAWVMPGVVARSDVGDEFFGPERSALYRNSGGTGPLEARIWPDLTVHDGDLLVEKGAASAFFPGRCDLPQRLAERNIDTVVITGTLTNVCCESSARDASTLGLRVIMVADANAARRDQDHNATLHTVYRTFGDVRTTDDVVALVKGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T275</accession>
    <name>A0A7W7T275_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="356"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="776" mass="81247" checksum="4B5F05E3192452A0" modified="2021-06-02" version="1">MRAAGTGSVATRDRLWWYYLVVGLAAVGVYYALPIFVGTIPLRVLVYCAVSASAAVAVGWGLRRHRPEHRAPWIFLGLGQLVYAAADTTFYTAHYVLLHTEYPSVADVLYLAHYPLAVVALLLLIRRRRRDRDLPGLLDALSLTVAAGVLSWVFVIGPQTRLGTPLPVELASLGYPVMDLALLLAALRLLFGAGARGASFVLLTGWLAAILTADTVYVLQRLSQTYAAGNFLDAIWLTGNLALGAAALHPSMGVLARPAEPAPARLTWPRLVVLAAGAIVGPIVLIVQYFHGEQRDVPVLAAGCAVLFALIASRLAGLAVDQRRLAITDSLTGLYGRRHFEACLDAEVARSRRTGADLGVVILDVDRFKSINDRFGHPGGDRVLVEIAARLRAVAGSGAVLARHGGEEFALLAVGVAGPCLVELTERLRGAVSRTPIEVGGRHSVTVTVSAGTASFAPHHGSASALVTSADQALYRAKEEGRDRAVAGAAQSFATQPSATQPPDGEPDDYLDRLADAVDAARGTPGRSAEVAEWARTLAERLSLDPAQVRTARRAGRLLDVGLIAHPCLWAVLERAACGHTEHHAFDRLPVHGRSSGGVAGGGAVGPASSVRARGGGGAATRSPVPGSEGVVDAGPGGSGLDVVAASPKPPGSAAGTGPVGREGHVETGALLVAVAPDHDDVAEVVRRYRDPWDGARIEARIVAVCDTWAALLAAGTPADKAADELRAARATVLDPDVVDLFLALRASGHAVAVREATAHRAPGRASRSRARWERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A1</accession>
    <name>A0A7W7T2A1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="25360" checksum="B89D845132F8FF30" modified="2021-06-02" version="1">MTVPVLAGRSKTQYAYEVLRDRIVGGRYGPGSRLVFDRIARELGVSPVPVREAVRRLQAEGWVVFEPNVGAQVADFAQDEYRHTMEALALLEGHAVATARLTNAILDRAELLNAMMRETLAVFDPLGFTRLNREFHLLLCDRSPNPRLRDLITKEWARLDLSRRSTFSLVPGRARESVEEHDELLRLLRAGAPAEVVERFARDHKLNTLRAVDSKSAAPLPGESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D8</accession>
    <name>A0A7W7T2D8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="4">
        <location>
            <begin position="171"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26172" checksum="955656D49E4AD227" modified="2021-06-02" version="1">MDERGDGRELSALVQAAFLAAANGDPPGIGHDPLRLLCRTCVELLPVDGASISVMTGAAEWETLYAGDEVLARAEAFQFTLGEGPCLEAFEHRRPVLLPDFGVDAARRWPVFAAQVAAEPIGGFFAFPLLSGALGIGVMALYRHHTGWLAPAELAVALHLVAMATGVVLGMRLDRLDADWWAALPLHREQVHQATGMLIAAFGIPPDEAFARLRAHAFATGRLVEEIARDLVVRRITPADLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2S2</accession>
    <name>A0A7W7T2S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15780" checksum="4EA2765FD0DEC938" modified="2021-06-02" version="1">MLMRTDPFRGLDRLTQQLLGANGTLTGPAAMPMDAYRAGDEYVVAFDLPGVHPDTIDLDIEQNVLTVKAERPRPDEDGAEYQVAERPRGMFSRQLFLGETLDAEHIQANYETGVLTLRIPVAERAKPRKIAISASGDTKQINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T2</accession>
    <name>A0A7W7T2T2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030921312" description="Peptidase_M14 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="236"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="813" mass="86499" checksum="A66EBE26F3D98D05" modified="2021-06-02" version="1">MRSRSTAIAVAAGLVLAGVAASPAAAQDRVLRADRSVVRACHEALLPPGTAGVDRREVTSGVDGLIQARLTPGGGSEGDWDLAVFDKAGGKVVAGSAALRSRELAESFVTKGQRLVVQACRYGGPARTVTLGVDFLALTPQGTPTRAEVVRVDTPERADKDKLLGLDLDLTEKGDATGVEVVLADDADRKTLRDSGLTYTTVDADLSRTSRDAAARDRSYATTVAASGLPSGRTSYRHLYDYEYELKELARRDPRRVKAFTLAEPTVEGRDVVAVEIAENVGNAADGKAVNLLMGVHHAREWPAGEHAIEWAYELARGGDQAVRSSVRGTRNVIVPIVNPDGFAVSREAEPKGDFTRFDYEMKRKNCRAADSPPELRTGICKANPGGTARGTDPNRNYAGFWGGNGAGLAWNSETFRGPAPFSEPETRNIRAIVSGRAVTNLITLHTYGNLLLRPPGVADVRPPLEEPVVKALADKMASRNGYRSIPSWGLYDTTGTTEDWSYWATGGFGFTFEINTAGFHPAYENAVVAEYLGTAPAAGAGKGGNRAAFLDMLTNAADPAAHATIVGTAPKGHKLQVRKTFRTPTSPVRQPDGTTTAPIQITDTVESDYTSTGGRFTWAVNPSTRPYVAGRYGRKPQGPPQAAIALANPPGVPAENKQYPTNAVAERIPFTVGGQGVDNGRFDVSVSWTSTATDWDLYVLDAAGAVVTQSASGGSNSERATLLDPPPGEYTAVLVNYDQVDPASPDDWAAGKVEFFSPLPPTYGVSEAYVLTCTDRHGRLVGLTDVFVDRGQTVDVGAVCSDSARNGKQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T376</accession>
    <name>A0A7W7T376_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="240"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="52258" checksum="00018A345C090A01" modified="2021-06-02" version="1">MTAFTARGVTKTYGGVTALAGADLTLRAGSVHALLGENGAGKSTLIKVITGAVAPDGGELRMGEEPVTFASTAQAAANGVAVVSQELNLFPDLDVLANLYPMREPTKTGFVHRREMRERALPVLQQLGLDVDPKARLGSLSLAQRQLVEIAKALLVEPKVLILDEPTSALDSDSSERLLGVLRVLRERQVAVVFVSHILEEVMSLCDEITVLREGRTVLDARPRAELEIGDIVHAMLGGREVSSVARAASTPSGPTLSLAGVTVPDRLADVTLSCRAGEIVGLAGLAGSGNTDVLEVIAGLTKAASGTVTLPDGKGAPRDFRSAIADGVALVSGDRRRVGLMLDKPIWENISQVQPVALAGATRKLSSKALRGTAHGLAERVGVHPIDVDLRAGLLSGGNQQKVVLAKWLAADPTVLLLDDPTRGVDLGARAEIHALLRSISDSGKVVVLCSTDLDELAAICDRVLVFHRGRLCAELAGDSIDQHTLLHTMNTGTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C2</accession>
    <name>A0A7W7T3C2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29007" checksum="B90157264241910D" modified="2021-06-02" version="1">MADQQAKPDREPGPVLVVIPTYNERDNIEKIVTRLHAALPDVHALVVDDGSPDGTGDIADRMSAADDRVHVLHRTEKAGLGAAYIAGFGWGLERDYGVLVEMDADGSHAPEDLPRMLAALGDADLVIGSRYVPGGTTVNWPWHRQLISRMGNVYSAIALGAKVKDITAGFRAYRADVLRNLKLHNVASAGYCFQIDLGWRTIELGYRVVEVPITFTEREVGVSKMSGDIVREALIRVTKWGLRRRYTQLRDLFAPKPKAPANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E4</accession>
    <name>A0A7W7T3E4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23113" checksum="1405F3B82A4131EA" modified="2021-06-02" version="1">MTKRTAARQAEAERNDRALLVAAREVVGSEGAHASVAAIAERAGVGIGSLYRRYRTKEELFQRLCAIALDDYLQAAREGLADPDPWAGLAHYVTTSLALGPGSLAPIAGTITVTPEMVEKSASGDEAVAGLVSRAHASGVLRPDATAADLELLIEQLSRSPLLDQLRKQGRADLLPAALAARARLVTIALDGLRAGTTPLPGDPPGYELFTERWSKPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L6</accession>
    <name>A0A7W7T3L6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="460" mass="48281" checksum="A1D23271F56D35BC" modified="2021-06-02" version="1">MDLTDACFAGAARQAELVRSGTVGARDLVAGCLDRIRRHDGVLNAFRQVFADRALADADQADARVARGEHAPLLGVPIAVKEDLALAGLPTTRGTAAVDRVADEDCEIVRRLRAAGAVIVGRTRMPELGLWPFTESTWAGPTRNPWSHAHSPGGSSGGAAAAVAAGLVGAAVGTDGAGSIRIPAACTGVFGLKPHHDRVPLDPERNPWTGLVAAGPITRHVRDAALLLDVLAPGEDCVAAQKTDPAPLRVAVSLRTWGPGIPVADEVRDVVLDTAALLVDLGHRVTRLDPDLRDVPGSAAFAARYLHCAATGEAALDHPRRLDRRTRAVAALGRAIPATAVRAALAQGHALVSHANSVLADHDVLLTPVLTRPPLRVGEWDRRPAVAALLAAARMTTFLPAWNVTGNPAAAVPAGRTRTGLPLAVQLVGKPRDERTVLALAGQLERTRPWTDRRPPRHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L8</accession>
    <name>A0A7W7T3L8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-methylisocitrate lyase-like PEP mutase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="24656" checksum="0B85AC4476059FDB" modified="2021-06-02" version="1">MTSRTDRAKLLRALHVPGDPVVLPNVWDAASARAVAGAGFPAVATASAAVSASLGYADGEDMPVREAFAAVARVARAVDVPVTADVERGYRLSPDELVGLLAEAGAVGCNLEDTDPATRGLADVDRQAGFLAAVRAADPDLVINARTDARDYDTAVDRARAYLAAGADSVYPIFLDHDRIADFVRAVDAPVNVLHRPGTTPPAGLAALGVARVSLGPFLHREVMAHLAAVVAGVHGGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T6</accession>
    <name>A0A7W7T3T6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20568" checksum="DA79110FE70806CA" modified="2021-06-02" version="1">MGDQELWDAAVTGDAEAFGELFGRHHDAVYNYCFRRVASWSVAEDLVSAVFLEAWRTRRRLVLDTGSLLPWLIGVATRVTHRHRRSGTRYDALLRRIPAGPPEPELAETVAAKIDDERRMADVLAAIAGLPKRERDVIAVCVFGELDYASAAIALGVPVGTVRSRLSRARRRLAALVPPVPLSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T413</accession>
    <name>A0A7W7T413_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="220"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="535" mass="58265" checksum="B41255F6B94F01B5" modified="2021-06-02" version="1">MIYVLVALVLALAFAGWKGLRRVPPGHVGLVEKTVGLSRKPGDDPRVSHLGSRGLQAAVLRGNTTTWLPTFAYRVRIVPMVTVPNGTIGAVVAKAGRSRELGEAFAGYVRCDSFQDGVSFLREGGVIGRQQQPLTGGTYSINTDLFDVLTVDSPEEDLAREELTANTLREVSLAIGETGVVVTHVGASPVPGELGPPVAGHADFQRPWDFLAGGGRIGVQRAILSGGGRYAINPWFAKVVKVPTRVLKLEWNAEPKAESNFDASLDQVTLEVQGHTVWLDMEQNVEILPEAAPRLVQRHGAQGEDGRESVQHFVGKDLASTVTGYFRRISPHYRIQQFITEYDAVCNELAAEVSQALAPLGVRAESTTLGNWRCDDDEINAIRRKIAHQQELAKLEQERLVELKAMLAGEEVRTKIDLQRVKVDEARRKLDLIKLTTMVELLGPHNVALERMLAQWVKANVPQFVGGGDTGMAQALLQAMPFSQAKDMLLAMTNGAQPPLPDTPDRPELAAHGSTDDLDPTSPGADDLRLDDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T441</accession>
    <name>A0A7W7T441_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="2">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">clpP</name>
        <name evidence="4" type="ORF">F4559_003530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21168" checksum="9F9AEFC4492F7F16" modified="2021-06-02" version="1">MSTYTIPNVIARGAGGERIMDVYSHLLSERIVYLGTAIDSGVANALIAQLLYLEADNPDREINLYINNEGGDPAAMLALYDTMRYIKAPVTTTCVGQAVATGAVLLAAGAVGRRFVLPHSRVVLHQPAAQGRGTIPDLILQADEVVRVRTQLEEILSVHTGRAVTRLRHDTDRDRVFDAAGAVAYGLADHVLDHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T454</accession>
    <name>A0A7W7T454_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="33109" checksum="5CBE99929A5911DB" modified="2021-06-02" version="1">MRAAVVDRYGPPEVVRVAEVARPVPRAGEVLVRVEAVAVTSADARIRGARFPSGFGVFARLAFGVVRPRRKVLGGAFSGVVVESAAEGFTAGDEVSGMTGVRFGAHAEYVAVSAARVARKPAAVRHDDAAALLFGGGTALHYLRDKGSLAAGMSVLVNGASGAVGTNAVQLAKYFGAAVTGVTSARNADLVRGLGADHVIDYADGGLVRTTDRFDLVLDTVGTLSIASGRRLLTDRGRLLLAVAGLGDTIRARGNVAAGPAPERAADFAFLLDLAAQAKIVAVIDATYGLDDVVTAYKRVDSGRKVGNIVLRPARNPPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T466</accession>
    <name>A0A7W7T466_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="48579" checksum="6A04315CE83B3827" modified="2021-06-02" version="1">MSDDIEAQFAQWRDFVRRRPELRPADVAELEDHLRGSVEELRAAGLSGDEAFLVAVKRMGSLDEISREFAREHSDRLWKQLVLTGPTPTRSRAGLVAMVVCAAGAALSIKVPALFGVDIDHDAEAYLPNFALFTLPWLAGFLAWRRQAPRIVLGVLAVVFALGAVAANAYPLAETSQSLIVSSVHLPIALWFAVGLAYVSDDPRSPRRRMDFVRFTGEWFVYYVLIALGGGVLVAFTVGTLNAIGVNPEYFVTQWLVPCGAMAAAVVAGWLVEAKQSVVENIAPVLTRLFTPLFTVALLAFLVALGLTGGGIDVQRQVLILFDLLLVVVLGLLLYSISARDPLAPPGVFDRLQLALVLSALAIDVVVLLEVAGRITEFGTTPNKAAALGENVILLANLGWSAWLVLGLVRRRTPFAALERWQTAYLPVFAGWAWLVVLVFPPVFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K5</accession>
    <name>A0A7W7T4K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="59"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="843" mass="89519" checksum="A6AECCEC00F2B78B" modified="2021-06-02" version="1">MEAGSVNQFAVAGIAYQSGRDMIVHEAPRVAWPVRVGAPPPAARHHRDRDVVLEPGRDVVLTGLGGVGKTQVAARFAASVWTDSSVDLAVWVTAVSRDAVVTAFAEAARRVSCCRDDCPPDDAAEAFRAWLVSCGLRWVVVLDDVRDPHDLRGLRPPSSGWTVITTRRRDRALGQAIVELDVFSVEEAVAYLASALPSHAHEELAGLAEDLGRLPLALAHAAAFIADKPLLSVAGYRKRLADRCRTLADVMPSGTEPVDDRVGAVAATWSLSIDLADGLPPRGLARPVLDLASLLDPAGVPVSVFEQATGLEVDDVHDALACLHRLSLVTLDPDRPARAVAVHALVQRAVRDTFTPAKTSELAHVAARALTDLWPATFDPESAQAFRSAALALHANTTPALREPDLHVVLFLVGRSLADAGQSAAAVTYFRALHAEADTHLGADHRDTLTARHNLAAALGELGRPAEAVAEYERLLADRLRVLGPDHPDVLPTRNNLALWRGESGDAAGAADEFAAMIADSTRILGPHHSGTLTARHNLAYWRGEAGEHTGAIAEFRALLADQVALLGPDHPDCLTTRHNIATWLDWVGDSAQAIAEYEALAADQCRVLGANHPDLLLNRHNLAAARVVLGGAADVLGQFEALAADCLEALGADHPLTLTVHGGLANCRGHAGDHEGAARLFAESAADRTRVLGADHPSTLVSRSNSAYWRGKSGDAAGASTAYEALLPDCLRLLGPDHHHTLSVRHNVARWRGEAGDASGALAGFTTLLPDRVRVLGPDHPQTLTNRHEIARWTDASGDVPGAVALLETLLADRNRVLGPDHPDTALTLRDLDRLDGPAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U8</accession>
    <name>A0A7W7T5U8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="6" type="ORF">F4559_004475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="35836" checksum="61265F5A0059BADC" modified="2021-06-02" version="1">MTLRFGWTTGACATAATTAAYTALLTGEFPDPVGITLPKGRTPEFALAREELHADRAMAAVVKDAGDDPDVTHGALVRATVTHGEPGSGVVFRAGPGVGTVTKPGLPLDVGEPAINPVPRRLMREHVARVAADHGGTGDVVVEVSVDHGEELAKRTWNPRLGILGGLSILGTTGVVVPYSCSAWIDSIRRGVDVARAAGYTHVAGCTGSTSEKVAAELHGLPEDALLDMGDFAGAVLKYLKRHPVPRLTIAGGVGKLSKLADGHLDLHSGRSQVNLEFLASLAPDLAAEIREANTALGALRVCQAAGVPLGDLIAARAKETADGVLRGTPVAVDIVVIDRAGVIVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T669</accession>
    <name>A0A7W7T669_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10757" checksum="6047BCB42E5693FC" modified="2021-06-02" version="1">MRYTVRLRSGDFTKAATLAGLRSDCARSKAMGVHRSTVTRVLAGELRPGAAFIAGALTALHPLDFTDLFEVVEKVRPMTRPKPGSGSHGHVVNLPENSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T699</accession>
    <name>A0A7W7T699_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S12 methylthiotransferase accessory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="370"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="735" mass="80785" checksum="5B465DD417ED8904" modified="2021-06-02" version="1">MRTRERIAFKRHLKTEIVPGEAVYLVSDDHVTTLQGRHVEALAPLLDGTRTPDRVLADLPADIPADQARRLLDRLDAAGLTTLLPDDDPEDDPEAAYWDAARLAAPRGRVRVVRVGDVPFDTTVDALRRAGLHVTDDDADFTIVVCRDYLDPGLRVVDRGTTPWLPVKPTGARAWVGPVFTPGDGPCRRCLVTRLAANRPAEAHLCASLGRPGPLARPLVGLAPVAAIACHTAALEAAKWLAGHRPTGRRAIWEFDSLDLRGNRHEVSRLPQCPECGDPGVCQERNTAPVLLRSRTKRSVDGGGHRSASPGEVLDRYRHLVGPVTGVVRDIRRDDRGHAFFNSYRSGTNTAVGPTGLAALRSTLRCENGGKGVTPLHAEVGALCEALERHSAVHRGDETVVRGSFDCLDDAVHPDSVQLYDPRQYVDRHAYNAAHSAFQHVPEPFDDREVLDWTPVWSLTARRHRLLPTGMLYYGAPSPASVTANSNGCAAGSSLEDAVLQGMLEIVERDAIALWWYNRTRMPAVDLDAAGDPFVDELRDVYAGLDREVWVLDLTADLGIPVLAAVSRRIGGPHDDVMFGFGAHLDPKVALRRALTELNQVMPAVCALREEDRPGLDVDLRNWLRDCTADNQPYLRPDPVLPVRRPGDFGYTPDDDLLTDVEAVRSTLERRGMEVLVLDQTRPDIGLPVVKVVVPGMRHHWSRLGPGRLYDVPVELGRVARPVAYEETNPVPMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C6</accession>
    <name>A0A7W7T6C6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="18063" checksum="87F9D470C43DF1BE" modified="2021-06-02" version="1">MTATRRPWHRKRRHLGLLIIALCYAMIFVYEVGQDNGKPETPTDGVARDITCERRWFFLGASHVCRAVVHYEGKEYPNIFTYELGMDDVGQEVPVTRTGKYKKSQTPMFTTAPARTGVPMFVIPLVWFALGSTNVFLLIRIMLLTAPSQRPKSKTRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I7</accession>
    <name>A0A7W7T6I7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="331"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="569" mass="60652" checksum="858E9715764393B2" modified="2021-06-02" version="1">MVSLIAGHELTLPGLCGVGEPWGSTRRASANRSAVAHQVTTGEPLIVADTTVDLRVRGDALAGSPRVGAYAGFPLTDAEGRVLGSLCVLDHVPRQWSGAELDLLDLLAESCSSVLRARIAAADAKCEQVRSTRAEAALQAALDRSQLLLTASQALSRAEDLAQIRATVTELVSGQLAPVYVGLTLPEGRADLHRIDDPRQAVGPESGAEVYDVGDDAPIASTARRGVLSLYPDPASIAAAFPPAAQRRYAEMGLHAIACAPLRYADDTTGVLLFGWDRPHEVDLVERTVITTLAGYVTHALERADFLQSRVSVARRLQEAMLTRVPEVNGMRLAACYVPAASDDQVGGDWYDVIVPGTQHPGDSAGVVLVVGDITGHDIDAATLMGQVRSMGRQAAWERPAGPPSAVVTALEQACVATGLAATGTMIQAHLLPLADSSREWVLTWANAGHPPPVVRHADGTTTILHGHDMLFGHPHLRDRPVLDHQVRLLPGDTVVFYTDGLIERRGSDIDEGITNLREVLAALRVTDDPRHLVDECVRRLLVPVGRHDDDVVLLAAHIPTGPDRPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Q4</accession>
    <name>A0A7W7T6Q4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl carrier-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8929" checksum="710CBE0358249A37" modified="2021-06-02" version="1">MPPNTLGPSTADSLREIVAGIVGTTAADIAGDANLVFLGLGSLELMRLVTRWRREGLAIEFSELAAEPTIDAWAAYLDRTRGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S9</accession>
    <name>A0A7W7T6S9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-mercaptopyruvate sulfurtransferase SseA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6413" checksum="28F42DC72FE46705" modified="2021-06-02" version="1">MDALGAAGLARVGAYRGSGVTASSVVPAAEATGLTAAGKPAILYPDSWSHWCTDPAREVAAGSAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T729</accession>
    <name>A0A7W7T729_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">F4559_005151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="11644" checksum="EB189CE7CF291102" modified="2021-06-02" version="1">MRTRESAAVAAVALGGGLGGVARYGCQLLWPGQWGTLAVNVTGCALIGVLTVLLPRLHHLARPLVGVGVLGGFTTFSAYAVDVVRGGSVPYLVATPVLCVAATFVAVVATRAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T744</accession>
    <name>A0A7W7T744_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="40"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="441" mass="45994" checksum="6B3BBDEF45579603" modified="2021-06-02" version="1">MNYVGIRYNRLTMYFTLRWFVVESPRPRRVATWTGAPWLAVATVCFGAFLGQFDASVVTLALPAIGQDYGGSPEWVALAYLLTLVALVAPVGRFSDVVGRKIVYLYGFAVFTLASVGCALADGLPSLITFRVVQAIGAAMLQANSVALVAASAPGREHRALGVQAAAQALGLALGPTAGGLLVDAFGWRWVFAVNVPIGLIALVAGHFLLPRTAERSTATPFRPVNTVLLAAATTTALLLLSGVDEPLLLLVAVPAAIGYVLREPLLRKVGLGLFGAFCGYLVLFGPLVLIPFTATGPLWRTGLLLSALPLGFALTATVKWRWSGLFGTALSTVALVTMALGVVDVVTLGVLGLGLGLFIPANNARVLAALPPCDAGSGGGLVNLARGLGTAFGVALPLLLHDHHGPNVPFWVLAGVASVAALRPFGDKRGRPLQPKGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T752</accession>
    <name>A0A7W7T752_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">F4559_005158</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="5"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBB4967799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="452" mass="46312" checksum="0ED18FE3DC48FCED" modified="2021-06-02" version="1">MNWASLAYLVAALCFILALKGLSTPRYARVGNLVGAGGMVLAVVTAYAHGVVHNGLLILVMVVLGTVVGIPAAKAVKMTAVPQMVALFNGVGGAAAALVALTEFLAADGDLLFDLATVLTVLIGAVSFSGSVVTFLKLQEIMTTRPVLLPAGQSLGIGVAVASVVLSAAVLTTSSTALLVLLALAGLALGVLFVLPVGGADVPIAISLLNAFTGLAVAASGYVLGNTLLIVAGTLVGASGTILTRLMAQAMGRPLTNILFGAFSPRPEVAHTEEQRTVRSGTVEDVAILLGYAHSVLVVPGYGLAVAQAQHAARELALLLEARGIDVSYGIHPVAGRMPGHMNVLLAEADVPYDRLKELDDVNPGIGSVDVVLVVGANDVVNPGARDDPSSPIHGMPIFDVDRAKAVVFMKRSMRPGFAGVDNSLLYNPKTTLLFGDAKDSLTKLLAAVKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T788</accession>
    <name>A0A7W7T788_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16754" checksum="74E4533D9EE5226F" modified="2021-06-02" version="1">MPVVRVWHSGGVARLTHAMFSSIAALCCAMMAGVFFAFSAMVMPGLRRTDPEVGLAAMRAINIAVVNPWFVSLFLGTGAVSAVAAFTDGGLAITGAVLYALGGYVLTFAYHIPRNNALEREATSDYWSKYLNEWVPWNHARAGGSLAAAIVFLLAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A0</accession>
    <name>A0A7W7T7A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6579" checksum="9F157519C6AA2B2C" modified="2021-06-02" version="1">MDEKSFAALLSKALRGIDHPEIVVVEDLRNERGSASFDLVRIEFANGGEGFIGVHHQGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L5</accession>
    <name>A0A7W7T7L5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="164"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="41614" checksum="B521830C84A05E98" modified="2021-06-02" version="1">MLLRLAYLGVTNTFALLRLLPLSDRDKDTEILALRHQIMVLQRQLGDTRPRFSPADRAFLAALLHRLPTHALSRLRLLVRPETILRWHRDLRARRHAARSRPKRPGRPRTIRSIRLLVLRLTRENPTWGYRRIHGELLVLGITVAASTVWQILQDAGVDPAPERVSTPWSAFLRSQADAILACDFFETTTLSGARLYVLAVIEHASRRIRVLGATAHPTASWVTQAARNLVMDLEEAGSSARFLIRDRDGKFPALFDAVLADAGIQVGLTGVRIPRMNAIMERWIRSCRHELLDRTLIWNQPHLLHALRQYEQFHNTHRPHQGIANARPLRALPPAVTDQAAITRLDVRRQQRLGGILNEYHHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W1</accession>
    <name>A0A7W7T7W1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ORF">F4559_005563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="367" mass="40997" checksum="946359B3BF103A12" modified="2021-06-02" version="1">MNLDVEADIKDLSATLASIEAVMDLDALRAQVAELEQQAARPDLWDDQEKAQRVTSQLSHKQGELRRVVALRDRLDDLGVLYELAEDEGDEGSAAEADVERAKLREEISSLEVRTLLSGEYDERDALVTVRAEAGGVDAADFAEMLLRMYSRWAERHNYSVDVFDTSYAEEAGIKSATFRVTAPYAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVVPVVEQSDHVDIDEKELRVDVYRSSGPGGQGVNTTDSAVRITHIPTGIVVSCQNERSQLQNKATAMAVLQAKLLERQRQEEQAKMDALKDSGSSWGNQMRSYVLHPYQMVKDLRTEHEVGNPSAVLDGEIDDFLEAGIRWRKRRQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T847</accession>
    <name>A0A7W7T847_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor RsiW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="20197" checksum="6C2FFE3BCD925F44" modified="2021-06-02" version="1">MTDLRGWGLSEQHLLPDAVVAFVDGELSASAHGRASAHLARCPFCAAETYSQQQARSAVRAATTPSAPAGLLARLGAIPQEVELPSAPDGLAVTEDGRLVAVQRPDRAAAAFGSGPVLGQSRPFGTGSRLGGKRARQGAGAVVSGLMLGALALVVPGGDDPAPVPVQGPGAAPTTPAVAPASLAPVPVDSPLGVMRPVSGQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M2</accession>
    <name>A0A7W7T8M2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21316" checksum="996A225B93E1B883" modified="2021-06-02" version="1">MNLLALERTVVRVDVVDSSSGGVTRQRHLDRALGTVLDQVVDSVRHSRYADAECFRRDDGDSATLLVGAQVPGAWIASDLMRELTIALHDVNRPVHDDYRLRLRIAVDHGPTVMDPPHVNGEAVVTAARLVDAPALRRFVADERDVDFGLIVSDRFHRDVVLAGERGLGLVRFEPVEVVVKDFRQPAWLQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P8</accession>
    <name>A0A7W7T8P8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="279"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="537" mass="55642" checksum="2860AE6FCE66852E" modified="2021-06-02" version="1">MTAPATQAGRKRRVFADRSLTVKIMSALLLSSVVTFVVGLVCLAALSAASSATGRISTNVKALTLLNSVSLAGATGSEELLLAVSVGSPEAAQSHIAAMGAAFEKSGKLFEEYQKVTAVDDELLAEWGKVGAQYTDLIQNKLMPAAMSGDAATGIKVFADEVNPLLKQFDAISQKWLEAERARADADIASVDADERDSRTVAIILLGVGLVVSVAVGLLITRSIVKPMRKLSATLDSVADGDLTGRLDSASNDEVGRMTTALNQASEGMGRAVSAMADGIHSLRGATERMSQTTDHLTAGTQETNNQADVVAAAAEQVARNVRTVADGADEMSSSIKEIARSANEAADVAGQAVRAAEATNSTVAKLGESSIEIGNVVKVITSIAEQTNLLALNATIEAARAGDAGKGFAVVANEVKDLARETAKATEDISRRVESIQHDTGNAVEAISEIGQIISRINDFQLTIASAVEEQTATTAEMNRSVGEASSGVADIAANIAVVAKSAAESTASIAQTNVALKDLDRLSAELQGQVDRFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Q8</accession>
    <name>A0A7W7T8Q8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031255886" evidence="2">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="20407" checksum="99E4A243C4C2F567" modified="2021-06-02" version="1">MNRTFKVALAAGAATVALAACTNSSTDGTPTPATNGVASQTKSSSTTSGKPSNGDDLNISRFADKPCDLIKPDQLTALGNFRPGESSSAPLGPGCSWFGVDALKDTTFFVTLVTKGDNLESMAENAKSFPIFKRTTIAGREAYSADRTDGKASCSTAVSTSAKDAIFVQGRPPANGTGTADKSCQASEKVAAIVIGNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S4</accession>
    <name>A0A7W7T8S4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oligoribonuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">orn</name>
        <name evidence="3" type="ORF">F4559_005441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">3'-to-5' exoribonuclease specific for small oligoribonucleotides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00045">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="23287" checksum="80E18F76E934C264" modified="2021-06-02" version="1">MDRLVWIDCEMTGLELGKDALIEIAALVTDAELNILGEGVDVVIHADDEALASMPEVVVQMHAKSGLTDEVRRSTVTLAEAEAQVLAYVREWVPEPRTAPLAGNSIATDRGFIARDMPELDAHLHYRMVDVSSIKELCRRWYPRIYYAQPGKGLAHRALADIRESIRELAYYRRTAFVAQPGPSSEQAQAVAAELLAADEAKQGRFRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T960</accession>
    <name>A0A7W7T960_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022324">
        <property type="entry name" value="Bacilysin_exporter_BacE_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01988">
        <property type="entry name" value="EXPORTERBACE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="408" mass="42650" checksum="BEABD0A13BCF9C9B" modified="2021-06-02" version="1">MTSGGTLRALVGNREFRGLWIGSTVSTAGDQLAAVALSLLVFERTQSAAWTALTWALTLFPPLVSGPLLGWVADRYPRRTVMVCCAWLQAVLVGLMAIPGVPLWIMIVLLVTVLMISSPFLAAQEASLPSVLPEKRYDDGVALFGTSVDVAQMAGLAAAGFIVTQSSPQLALALDAATFVLVAVLVQLSVRFRPAADPHGGTHRNPEAPRGAFALLVTEPRLRSLMGMRLLAGLAMVPEGLAVPLAASLDAVWAVGLILAIEPAANVLGVAVLFRFVRDPAKRERLIGPLAILSLAPLVMFALDPNLTWTIALLVIAGMAGAYHTPARSAWMRLLPDAYRGRAYGIGRAALRSSQGGGMAVAGVVAHAVGSVTATIAGAGGIGLLLATQATVSWRRARARNDPEAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T991</accession>
    <name>A0A7W7T991_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase (TIGR01493 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22445" checksum="285463C9DA7A85BA" modified="2021-06-02" version="1">MTIRAVLFDFSGTLFRLEHDSLAAHADLMRALTAPVGVAEGLDFTVEEWERRDLDSQAHRDLHVAVLEKSGATDSEDFYDRLTGPDFWQPYPDTAQALGTALPTAVVSNIGWDIRKVFDRHGVTDRVDEFVLSYEEGVIKPDARIFRIACERLGVRPEETLMVGDSEEADGGARAIGCAVEIVDPLATAQRPDALLAVLRKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B3</accession>
    <name>A0A7W7T9B3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022399">
        <property type="entry name" value="HlxAse/secretion_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03819">
        <property type="entry name" value="heli_sec_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="57"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40460" checksum="C56A670123553799" modified="2021-06-02" version="1">MTDLVERVRRRLADTRSDLTSASVAAAVRGESGGVLGDEDMLNALTVLRQEFTGAGPLEPLLHAPDTTDVLVTAPDQVWVDDGNGLRRTPIRFPDEAAVRRLAQRLAIAAGRRLDEAVPYVDGRLSGSVRLHAVLPPIAPSTCLSLRVLRPAAHTLDTLCDRGTFDDEIAEVLHRIVLARAAFLVTGGTGSGKTTLLAALLGRVPHDQRIVCVEDAGELQPTHPQVVHLLSRTPNVEGAGEVTTRDLVRQALRMRPDRIVVGEVRGPEVVDLLACLNTGHDGGAGTLHANSPTEVPARLEALAALGGLDRTALHAQLAAAVKVVLHMHRSADGRRHLAAIGVLENNSTRITPAWTHTDGWHQAASHHLQTLITSSRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C9</accession>
    <name>A0A7W7T9C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5461" checksum="49424E615836815C" modified="2021-06-02" version="1">MTTQVPSRPRLRVVPDPEPRPKRRVLPVLLVPVALAVLLVVLRSRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D5</accession>
    <name>A0A7W7T9D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CspA family cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033432301.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7415" checksum="9193B92AE83FA916" modified="2021-06-02" version="1">MAVGTVKWFNSEKGYGFIAADGGPDVFVHYSAIQMEGFRTLAEGDRVEFEIQAGRDGRSQASDVRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J4</accession>
    <name>A0A7W7T9J4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PqqA peptide cyclase</fullName>
            <ecNumber evidence="7">1.21.98.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coenzyme PQQ synthesis protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pqqE</name>
        <name evidence="9" type="ORF">F4559_005876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[PQQ precursor protein] + S-adenosyl-L-methionine = 5'-deoxyadenosine + E-Y cross-linked-[PQQ precursor protein] + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:56836"/>
            <dbReference type="Rhea" id="RHEA-COMP:14800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:141026"/>
            <dbReference type="ChEBI" id="CHEBI:141027"/>
            <dbReference type="EC" id="1.21.98.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PqqD. The interaction is necessary for activity of PqqE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the radical SAM superfamily. PqqE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.4" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009975">
        <property type="term" value="F:cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00660">
        <property type="entry name" value="PqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011843">
        <property type="entry name" value="PQQ_synth_PqqE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00280">
        <property type="entry name" value="coenzyme_PQQ_synthesis_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02109">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="37991" checksum="80DE91260055EBA8" modified="2021-06-02" version="1">MAEAPFGLLAELTHRCPLRCGYCSNPVELIRREAELDTAAWRSVFDQARALGVLQVHLSGGEPLARRDLPDLAAHASGLGCYVNLVTSGLGLTPERLADLAVDHVQLSVQDADQADNDRIAGVKAFRHKLKAAQAVHEVGLPLTVNAVLHRLNVDHVGAIIALAAELGAQRLELANAQYYGWALRNRAALLPSRAQLAEADRVVAAARAHTDMEIVHVIADYHEAHPKPCMHGWGARQLTVAPDGTVLPCPAATVITGLGLENVRDRPLAAIWHDSPSFEAFRGTDWMREPCRSCVRREIDFGGCRCQAFQLTGDAANTDPVCSLSPHRPAVEAILDAATPEDLRMRKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K3</accession>
    <name>A0A7W7T9K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="36" mass="4076" checksum="CAAF79101BE4A386" modified="2021-06-02" version="1">MSERASLDSQDSSPTMRVRSQRHVRSRKMPDSTSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K7</accession>
    <name>A0A7W7T9K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14476" checksum="F5CF9337763262B8" modified="2021-06-02" version="1">MTDSTFDAFRQAEALLAERRPLDALRALSVVLEVAGDEPSVQLLAGRAYLGSAQFQRAEEAFRKVVDLDPSDYYARFALGRTLQRQSRLTEALAQFRMAAAMNPTPEYQEALGEVSARLAVERDRRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U3</accession>
    <name>A0A7W7T9U3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030685339" evidence="2">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="28937" checksum="54A741D5A699B4F9" modified="2021-06-02" version="1">MDTRLLRTLLVLARTGSFTATATQQHLVQSTVTSQVKSLERALGARLFDRLPTGARLTEAGRRAVEHAREVLAAEQRLRDAVRGSTAVEGDVRIGAPESVCAYRLPQRIADAALRWPGIAVHLNAVNTRPALAGVRSGTLDLALVLEESVAVAGLRATALGVEQIDLVTAPGVAEEERYFLLEEGCSYTDRFVRDLAPTPTITRFGSIEAVRSCAVAGLGHAVLPRVAIADHLDAGTLHSVRTLPETTLFLVTDPRRTPSAAVKAVIDAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y7</accession>
    <name>A0A7W7T9Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RecB family nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019993">
        <property type="entry name" value="RecB_nuclease_TM0106_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03491">
        <property type="entry name" value="TIGR03491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="2">
        <location>
            <begin position="449"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="545" mass="59960" checksum="E012DADAD5880691" modified="2021-06-02" version="1">MTSQVQLDAGVVTRCRRRVHLEHDPGSHDAPKAPPDPTGRQRKADATEHRRAVATSLGRLVGSDLIEIPVDAPTSARERATAEAMRSGVPYIWGAVLPRDEPGGRRGAIDLLVKDDTGYVPVLVVRHKVTDPGRGARTSPVTLPLPTGARVDPLRRVRAQPRDQMRLAHAQRLLQASGFAASGRSTGGVIGMDADVVVWHDLEASTWPGGRSALSEYDARFADRLAVATAAATGAPAMARPSRIVECRSCPWWPVCEQDLRKARDVSLVVRGEDAIALRKAGVDTVDDLAALDPHDKPVIPFVGMLHTDAVVLARAWLRDLTVVRRVEYLDVPRADVEIDVDMESFGDLGAYMWGCLLSGTDVGVEPGYRAFATWEPVPCDDEARSFAEFWTWLADVRRHALERGLTFRAYCYNELAENRWLLGSADRFAGRPGIPAVGEVRSFISSDEWVDLFGIVQQQFLCAHGKGLKTIAPVAGFHWRDPEAGGENSMRWYRDAVGMDGHPPEPAQRRRLLEYNEDDVRATHALRTWMTSDAMADLPFAGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB1</accession>
    <name>A0A7W7TAB1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">F4559_006808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="220"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="388" mass="40341" checksum="B65460BCB9466D04" modified="2021-06-02" version="1">MSARDWIEKDFYRELGVSSDASADEIKRAYRKLARELHPDANPGDTKAEARFKAVSEAYGVLSDASKRKQYDEARRLFAGGGGFPGGFGTGGGFDVGDLFGRQGGAAGGGAGGLGDLLGGLFNRQRGGGGGNRPRRGEDVETDVRIDFTEAVRGATVPLRLSSPSTCGTCAGSGARPGTTPRTCPACAGAGLVNRNQGAFAFSEPCRDCRGTGRLIDDPCPECAGEGVSTKTRTLTIRIPAGVDDGQRIRLAGQGEPGRNNGPAGDLYVRVHVNPHAVFGRSGNDLTVAVPVTFPELALGTTLTVPTLDGKVTLKVPAGTATGRVLRAKGKGIARRDGQAGDLLITLQVAVPNNMDAAARDALEAYAKATAQHDPRPELNALVEKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC8</accession>
    <name>A0A7W7TAC8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YjbI with pentapeptide repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="713" mass="77212" checksum="178EC786EDE88A7E" modified="2021-06-02" version="1">MTENGVRGLDVFDPSPPREFRLAAADIVRGVGDDGSWRLPLRKPDKAPVIKVVDRFVTGVLDLRAVDFPYLLEFVRCRFEYAPDLRQGNLAGIAFTGCRLPGLLGRNLSCANEVSLAHSTVEGCVDLTDADVQGSLDLQDATLCHVGELALHADRLKLAGALLARRVTVEGELRLAGARIGGNCNFSHSLLNNPTFHSVNGTGLEVGGSLVLSESTVLGTVQLSSARVSSKLTLRGTALADGRVDPESAADPHGDPAAPLVLDRITVTGDVQLDQGFDSAGTVRMVNAGLGGTLTLSGGRFDAVKSAPTNDPVGYGRALHLDGAQIGGDIIGRQAYLRGQVRMVDIAVKGSLTLDGSTIDNPRADAVLGNRSRIGSNLTLREVEVAGGIEVRGVTVGANLDLRGSRITSPGRYRHQPAGKPSLDLGGAVIGRDLICARGPKEFVAHGGVRARRAQVGRMATFAGAVLGDKLDSHALNALGMQVQELVLTVISPPRGDVTLRQVRCTSLDDNEQFWNATGWIDLEEFGYDSLRHPIDLRDDEEVLRRLRWLRSAMRRTYRPGPYDQFAAMLRAGGNDEHAALVLVEKQRLRYRAVAEGRKPLKPLVLVWSWLQRSMVGYGYRPARALAWLVVLWVLGSLWFQFHDPLDEINSDDTLPWNAWLFTIDLVVPIVDFGNKNRWQTPGASQWIASGLIVMGWVLATTVAAGMTRMLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAL0</accession>
    <name>A0A7W7TAL0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11928" checksum="88D531EA0EA2C440" modified="2021-06-02" version="1">MQIPAVLLPHTITLRRYLGTGPYGDVHADPVVIRRTFVEDRRRLVRSSTGEEVVSETTVRARPDVHVPVGSLVTVWAGTPHERNARVITANLFDHPSSWSHVEVALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAP9</accession>
    <name>A0A7W7TAP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="213"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="44228" checksum="C4D6A99C3C769F15" modified="2021-06-02" version="1">MRIAIVNNFFPPRMGGSAYVSDTLARHYAAAGHEVLVITAAYGGAHPVEERDGIRIVRLPSWTLPETRISFNFDITFALKWGNRKRVFRLLDEFKPDAIHQHGQFFDLTWQSGLWARKNKVPTLLTLHTRLQSPVKLVHGVFRVLDALVVRPITSYNRPTKVIAIDTIFDEYIKKRYKIPDARIEKLAVGVELDRFRNLVRAEERVRVRKEYNLGDGPLIASLGHVIPVRDRLNLVEALPKVLAAHPDTKVMVIGGLYFTAFLDRAKELGVDHALICTGTLPKPEIPGLLAAADMEVHDLQGFGIGIASLEAMAAGTPTVMAERADYFPGVAMTNGTESLLTKPGDHQGLADAINSLIDDPSLAEKVGEAGRQWVFENFDMPKICEANLDILKSISGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBQ7</accession>
    <name>A0A7W7TBQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="131"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="354" mass="37852" checksum="20F1C571E00C7314" modified="2021-06-02" version="1">MQITVGVGAGARHLGVDRVVDLGPLHPSAHGAYRLRLTVRDDSVITAAEPLVGHLHRGAEKLFEVRDYRQVLTLANRHDWLAAFCNELAVALAVERMTGMDVPPRAQVLRAILCEVNRVVAHVVFLAPITGARGREAVQTVLEEASGGRVHFMFNRIGGLREDVPAGWVDRTLDALSTVDVGTVPEGLAGLGVLSREAALGHGVTGPIGRASGVDFDLRRDDPLPAYRDLGFTPVVRSDGDAHARVRTMVDEVGQSRTLVRTLVGLLPGGPVNLRLPKAVKAPEGSVYTWVEAPLGTSGVHLASRGEKTPWRLKLRTPSFNNVQALSALLPGTRVDDLPAVLGSFAVVVGDIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCH4</accession>
    <name>A0A7W7TCH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="645"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_21" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133374" checksum="259701EEB31699B9" modified="2021-06-02" version="1">MADRTGDRGVLACTVVARNYLPAARVLAASYLEHHPDDRFVIAVIDAPRGEGEPGDGRLRIVGPEATGIDPDDYLRMATSYNVTEFATAVKPYLLRELRREADVVMYLDPDIQVFAPMPELPVLARAHGIVLTPHFLKPLPRDGKDPSEAAIMGAGIFNLGFVATGPGSGDFLDFWAERLRHDAVVAPERQLFTDQRWVDQVPALFANHVLRDPGFNVAYWNVHERPVDEVDGTYTAGGQPLRFFHYSGYRPERPWLLSSHTPSKPRVVLSENPHVKALCDAYGRALREAGYAETLESIPYGFAKMPDGTPIGPAVRSLYREAWVKAERKGKPLPPHAFGPDRGAALRRWLAEKPEDAPTGTTLNRLTLAVWESRADLRSAFPQPHGRDAAPYRTWCSTSGVVEASLPEWALPAEPVEPTEPTAEFGVNVVGYLTAELGVGEMGRIVHDAITGAGVPVASVVEDRLVSNRTGLDRPETTGEPRFPISLLCVNADQTRAVLENRPHVAHHRYRIGLWAWELEEFPPSMHEAFALVDEVWTVSDFCREAIARHSSIPVRTIPVPVRDPGEPAPKADGPVTFLFAFDFHSIGERKNPWGVVEAFRSAFPDRDDVRLVLKAINGAKNPTVAERLRVLVMGDPRIELVERYLSVAELDDLYASSTAYVSLHRSEGFGLTVAEAMVRGLPVISTDYSSTTEFLDDKTGWPIPYRLVPVGKNNGPYPPDARWADPDLDAAAAAMREIADHPEEARRRGRAAREHILRTRSMAAASRWMHDRLKEAHDRRHAGRVQVEGVADPLVPLRDSRQALLWRPDAGAPSRLPGAPALRKAVLRAIDHYDVHQRKVMGALVDGVEGSLAEVVARLTAVEAGVDSVRASTDGVRARLAGVRDEVLDAVGDELADVRESVRDSVDAFERRIDQVHARLDADERKTIDMFADRDKRADGREEQLADLTTAMHAVEDAARLRHAPVPAGADVVLCDAGALLLPADDVVRPWLAYHRSWERDEADLMARLVGEGLFLDVGAHVGYHTLRLLQRGGTGAVAVEANPVNAEYLRRNVLANVGRPGAVAVVPLAAWDHDTTIRLAQAEAGNSGDYRASEGGDGVEVRAVRLDGLAELADRTVSLVKLDLQGRDHRALAGLTAVIDRDRPHVVCEFCPDAIRELGDDPSDVLLGYRKLGYTLVPLRPGGPVEGDHADPALVAEAEDTAGGFITLWLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTA2</accession>
    <name>A0A7W7WTA2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="11" type="ORF">F4559_000228</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="952"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="959"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="962"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4962869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1298" mass="144539" checksum="650E4D9B490562F0" modified="2021-06-02" version="1">MLDVNFFDELRIGLATADDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVIVGVNAELRHNDLPTLESEMQVERKRVENRRDADVEARAQKLEADLAELEAEGAKSDVRRKVKEGGEREMRQLRDRAQRELDRLDEIWSTFTKLDKAQLIADELLYRELYDRYGDYFTGAMGAEAIQRLLGDYDVDAEADNLRETIRSGKGQKKLRALKRLKVVAAFQATRNNPQGMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQEAVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKQMALELFKPFVMKRLVDLNHAQNIKSAKRMVERARPAVWDVLEEVITEHPVLLNRAPTLHRLGIQAFEPQLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARVLMLSSNNILSPASGKPLAMPRLDMVTGLYHLTRHKEDDLGEGLAFSSPAEAQMAYDRKVLGLQAMAKIRISDKNPPKGQEPEGWEPGQPWLAHTTLGRVLFNEILPQDYPFLNEVMPKKRQATVINDLAERYPMVTVARTLDKLKDAGFHWATRSGVTVAISDVLVPEAKQGILDEHEKLADAVEKRYQRGQLSYTERNSELVKVWTKATEEVAEVMEANFPEDNSIRMIVKSGAAGNMTQVRSLAGMRGLVTNPKGEYIPRPIKNSFREGLSVLEYFIATHGARKGLADTALRTADSGYLTRRLVDVSQDVIIREIDCNTTRGVNMTVGERLGDKVGLHEFAQTSVYARTIAEDITDADGNVVLNRGDDLGDPALQTLINAGVVRVKVRSVLTCESAVGVCASCYGRSMATGKLVDVGEAVGIVAAQSIGEPGTQLTMRTFHQGGVAGDDITTGLPRVQELFEARVPKGKAPIADVDGRVRIEDGDRFWKITLIPDDGSEEIIFEKLSKRQRLANTPTGPLQDGDHVAVGQQLLEGTPDPHEVLRVMGPREAQLHLVQEVQKVYRAQGVAIHDKHIEVIVRQMLRRVTIIDSGATEFLPGSLVERSDFESGNRQVVAEGGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINGRSDKLIGLKENVIIGKLIPAGTGINRYRNIQVQPTEEARAAAYAIPSYDDGYYTPDVFGTGTGAAVPLDDYDFGRDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTY0</accession>
    <name>A0A7W7WTY0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-subunit dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="14605" checksum="786AE63C030A3D59" modified="2021-06-02" version="1">MNKWQRIAVVTVLLAEVAVTLLPIARTLSVLDELTNLERQAVTVSAEDRTATEAKRRHAPRVGVRVATITILMVTAGVAAATVLARPRSRSWLGTFAGTRVAVVGLAWSYGLPAVAALAGVSLVAVSTLVLMPGRPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU02</accession>
    <name>A0A7W7WU02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Osmoprotectant transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23021" checksum="07C9FC965C676BE0" modified="2021-06-02" version="1">MGDIGRYLGDAANRAALLDMLLEHVYLSLVPLVVAVLLAIVLGLVCHRYRRVNGVVVALSNVVYTVPSLALFAIIPAVIGTQVLDPLNVIVALTIYTTALLVRPVVDALDAVPGHITAAATAMGFRPTRRFLTVELPLAVPVLAAGVRVGSVSNISLVSVGALIGTGGLGVLFTDGFRQRYLAPILIGIVLTLLLALVVDLLLVGVRRALTPWTRAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU11</accession>
    <name>A0A7W7WU11_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinone biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="638" mass="69740" checksum="B4EE827A0893FDFF" modified="2021-06-02" version="1">MDDFLLYSVGVPLTFLALVLGMALAARRILGLRVGLIRTTIACMLGFSFSEAVLSGIADARDTPALATVQLGISLLLMIGTLTFIEIVVPTGSVPPPTEWVRAIRGRIARTRRYSRITAIAVRHGLGPYLRGRERTDTGLARSLRRALEDGGVTFVKLGQVLSTRPDLLPADVIDELTRLQDKVSEAPWDRVREALTADLGRPPEEVFAEFDEKPLAAASIAQVYRARLHSGEDVVVKVRRPGVRRTTEGDLDIVTRLAGTLHQRTRWGRAIGVRDLAAGFAAALREELDFRVEARNLHAVRSGAGAPDVVLPQVFEDLSGERVLVMEFLSGVPIRAADVEPERRTALARSLLEVLLHQVMVTGVFHADPHPGNLLLLSDGRLGMLDFGSVGRIDAALRSALGKLLLSIDHGDPAGVRDALLELVSRPDEIDEQRLERALGQFMARHLGGGGRADVDMFGDLVRLVYRYGLSIPPEIAAVFRTLATVEGTLGTLSPGFDIVVESRAFADRVFESRLTPESVRRTLTEELYSVLPMLRRLPRRAERISSALEQGRLSMGVRLFADERDRGFVTGLLHQVMLTVLGATAGLMAALLLNTTGGPRVGPDLTLFQVFGYNLLVISMLLGMRVVLTVFRPRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU94</accession>
    <name>A0A7W7WU94_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015104440.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="12804" checksum="DBFBE857081858C8" modified="2021-06-02" version="1">MSAEDLEKYETEMELSLYKEYRDIVSQFSFVVETERRFYLANSVDVQVRNADGEVYFEVRMSDAWVWDMYRPARFVKNVRVITFKDVNVEELDKPDLRLPEDGPFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUI3</accession>
    <name>A0A7W7WUI3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipoprotein with Yx(FWY)xxD motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005297">
        <property type="entry name" value="Lipoprotein_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03640">
        <property type="entry name" value="Lipoprotein_15"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030959532" evidence="1">
        <location>
            <begin position="31"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="30230" checksum="E5EFA0465BB35557" modified="2021-06-02" version="1">MTRFRVVAALAVAALVGACGQQNGAQPVAAQQQPQQEQQLREQQPAEVALTAGTIEGLGTVLTDAQGMTLYRFDKDTAKPSESTCDGDCAAKWPPALAGDGDIQVEGVDRSLVGTVDRQEGKQLTIAGWPLYRFAQDQAPGEAKGQGVGGTWFAAATDGKKAATDDKKAAPNAGLVLTTSSVGDLGTVLTDKDGMTLYRFDKDTAKPAKSNCEGDCAAKWPPLLVQGDFEVRGVDRSLVGTVDRPEGKQLTVAGWPLYTFVDDKVCGDAKGQGVGGTWFVANPQGGKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK2</accession>
    <name>A0A7W7WUK2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28804" checksum="F962E43D84D509C7" modified="2021-06-02" version="1">MNRFLQRWLVFVGLVAAWELATWIADDPFFPRPSVIVESAHLLWLSGPAGHLFLTDAVFEHVGPSLARLLGGWAIAGVVGVSLGVLLGRSPTALQFVGPVLTFLRSIPPPALVPVFLLVFNIGTQMQLATIVFGVLWPILLNSVDGARSVDETKSDTSAVFRIPRFQWITGVVLPAAAPKIFAGLRVSLSLSLVLMVVSELVGTDNGIGSQLLVAQREFDYPDMWAGIVLLGVLGYALNTVLLAFERRALSWQPKRERTPATVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM0</accession>
    <name>A0A7W7WUM0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="33306" checksum="0D8B4CADC3C82935" modified="2021-06-02" version="1">MTEQPRLQLPPAVMKVVLGRQLARLRENAGRTQEDAAGALGCTQKKISHVEGGSGISLPELDVLLDRFGAADSDRDYARALQAESDNRRKKGAFSTRFPEHLRLLVDMEPSCDRYSSYQAMFVPGLLQTEAYMRMNLRAWRPSLSREHADASVTNRLARQRVLDNLHQRFWFIVDEAALRRASDPAVLREQVRHLVDHVLDRPNVEFQVVPFDVGFYMGQGRPYSIFGYDTTPTVDIIYLEHDEGGEYVDHSKRTVRYLTRWDYQRATALGPEQSRRLLLDLAAGSATKGSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM1</accession>
    <name>A0A7W7WUM1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21588" checksum="46FD861A3E55FDD3" modified="2021-06-02" version="1">MTWRIGALIAVVVLVVGAVAAVIVPRFGTDTIDRSQPALLQSVRDLSQYHAAAGEFQVVLDIENDVRYVPAALAGKRTLFVAAGSVNAYVDFAGIEEKALRIDQEHKTVEVDLPAPALDKPNLHQEKCYVFAQERGLWDRLTDMVETTDQQPFYVAAEEKIAAAAKESGILAKASDNTRKMLSGLLGALGYQVTFAKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ1</accession>
    <name>A0A7W7WUQ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="39"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27929" checksum="B3ABBE51F7FDFEFD" modified="2021-06-02" version="1">MPTPLLWRVLTAVDEAFVGLSGRLRVTGDVPADLRGGPLLLASNHIGNLDPFVLIAACRRIGIAPRFLLAGGLLDAPIMGPALRASGHLRVDRASADAGEAYHRTVEVLKRGGDPIALYPEGRISLDPGLWPERGKTGAARLALSGNVPVIPISQWGAHEAVYWGNTRVSGWDDFKPYLTSYLGGLRRRPTFRVHFGKPVDLSDLVDGRPGDARRAHERIMRAITEGLVPLRVGELDRPRFRDPTRPTTGNSPWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV31</accession>
    <name>A0A7W7WV31_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7962" checksum="1451B28099697854" modified="2021-06-02" version="1">MHKKNESGAEVRYRFHADREVDRYLMLDKRAETIQPADGDHDGVFQAAAGKLARAWVDTKAAPDRLIHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF0</accession>
    <name>A0A7W7WVF0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="40"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30649" checksum="A40A54324E19A7F9" modified="2021-06-02" version="1">MDAMIRTYLPTAEKADQFRTLARLSRQRSRPRKVVGARDHRYLSLERYASEIRMVYNEIPGLAQTEEYARAALLGSPTIVASTVQAVAAERAERGRNVLHANGPRVWIVLGEDALDRSSGGPEVLRRPLEHLRTLAALPNITLRVITRAAGNVAGLSAGFTLPHTDVGLAFAYITEPLKGDYVRAEDDHMTIFENSWACAASEKDSAAILEARISDRHDRQGQNECGTWRPDFRTCDGARQGGPTPATTRGAWKSRTGCGPCATARTPMRRCGFRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI0</accession>
    <name>A0A7W7WVI0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32545" checksum="1E043477EE664CCF" modified="2021-06-02" version="1">MHDEDLQLSLWTCYELHYRGFDDVDDTCEWSPEVIVFRGLLEKTFLAGLRAIAPVEDVTPEEVPDALADLVAADDGPPLAGYLQREATLDQFREFVALRSVYHLKEADPHSWAIPRLDGGAKAALVEIQADEYGGGRVERMHSELFRDLMRFLDLDDTYGHYVNQASAATLAVTNTISLFGLNRRLTGALVGHLAAFEMTSSLPNRRYGTGLRRLGGDARATRFFDEHVEADAVHEQIAAHDLCGSYAKAHPEAAGDVLFGAAACLSVEARFGGQLLHRWARGLPALLVPTLGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT9</accession>
    <name>A0A7W7WVT9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="213"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="35095" checksum="636A00266CCFF91F" modified="2021-06-02" version="1">MSYSLSTTGVPATQQFDLWQSAVSQTFVPLEATTGEHGPFRGRLRGQSLGSVSVYEASADAHTVRRTARTISRAAPDFYKLSLQLHGTAKLSQDGRQAALRPGDFAIYDVTRPYTLAFEDVSSTLVLMFPRSMLCLPSGQVENLTAVRFVGGQGVSGIVSTTLVQLARNIDDPQVHGSVRLARNVVDLLGTALADQVEYTDVPAESTRAAMLVKIKSYVEAHLEDPELSPGDIAAAHHISTRYLHKLFSEAGTTVSAWIRHRRLERCGQDLADPGKHQLAIGVIGARWGLVDASYLSRAFKSEYGLSPSEYRQRSVEHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU7</accession>
    <name>A0A7W7WVU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol alpha-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.345</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.345" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043750">
        <property type="term" value="F:phosphatidylinositol alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="39656" checksum="E5AA86DD7FB04216" modified="2021-06-02" version="1">MKVGIVCPYSFEVPGGVQAHVVDLARALRGLGHEVEVLAPADDDTPVPEFVTPAGRAVGIPYNGSVARLSFGPVSFARVRRWIAEHDFDVVHLHEPTAPSLSMLALMTADGPIVATFHTSTPRSKMLSAFQVVLQPFLEKITARIAVSALARRVQVEHLGGDAVEIPNGVDVAFFADAAPLDGYPLPSGTVGFVGRYGEPRKGMPLLLEALREVPGVRLLVVGRGDEDELRRQAGPELASRIVCLGMVDDETKARALRSVDVYCAPNTGGESFGIILTEAMSAGAAVVASDLDAFRRVLDDGRAGVLTPVGDAAGLAAGLRSVLDDREARARYVDAARQRVMTYDWSVVAQQVLRVYESAMAADPRRVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWE1</accession>
    <name>A0A7W7WWE1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system Cascade subunit CasB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013382">
        <property type="entry name" value="CRISPR-assoc_prot_Cse2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038287">
        <property type="entry name" value="Cse2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09485">
        <property type="entry name" value="CRISPR_Cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02548">
        <property type="entry name" value="casB_cse2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22828" checksum="43467F5D59AE10D8" modified="2021-06-02" version="1">MTEPSLKDRRRAFTSYLYGLYHGLTSRDPVRAAESRRVLARLRRMFSGPRQEADAYEFVFAQDPPRAEEEVWLLVAGLFALHPQPRRHASRRDSLGGSMADLLAQRGFAATRRFADLVARDRDGLPHHLRQTIRLLASHDIRVDYDRLLDDLVVLLAADREEDARRVRLRWAREFHRPATAPAPQDPSTPEHPSTAETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF7</accession>
    <name>A0A7W7WWF7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkylation response protein AidB-like acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="123"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="4">
        <location>
            <begin position="249"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="40059" checksum="62EA2B736499381E" modified="2021-06-02" version="1">MTAAPDLSDEALAAVTAEVAATATAYDRSGEVPVKGLDAAHRAGLLTATVARRHGGPQVGPRDTARILTALGEGDPSVALIAANTLMAHAAEAAEPHWPAAYYADLLARSALGPAPVNAVRAEPELGAPARGGLPRTTIRRTADGWVLDGHKSYATGGTALAYHVVWAVVDEPGPAPRVGHVTVPGDRPGITWLDTWDHLGLRASNTHDVVYESVTLPADAFVEIPRGEDGVYRDPAAMAGPGGFAHPALYIGVARAARQAFVDFARSRVPAALGRPIATTERIQVVAGEIDLLITQAETLLHGALLRIEAGDPIGPGLSVVKVAIARSVVAAVQTAVAALGNPALSRHNPLERHLRDVLCVRVHPPQEDAALLAAGRRLLRPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH6</accession>
    <name>A0A7W7WWH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formiminotetrahydrofolate cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="FTCD_C" evidence="2">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="19465" checksum="26958F828DA53C40" modified="2021-06-02" version="1">MGEWLADLASGASTPGGGAAAALNAAVGAALVSMVCNLTIGRPKYAAHEETMTGALHEAERLRLTAVELADADAVAFDAVIAAYRLPKETRGTAVRDALAAAADVPLRTAALAASVVALAESVLAGANPNVLSDVAVAASSARAALESAAVNVEINLAGLGDDPRRSSLAAALDGHLPAIGRADAVVAAVRERVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ4</accession>
    <name>A0A7W7WWJ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031028102" evidence="1">
        <location>
            <begin position="21"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24264" checksum="F660BAAE736AEDCD" modified="2021-06-02" version="1">MRGHVIVVLAAVLVGCGATAPPLPDGLVLRAQQLVGMPSPDPGRLPEFSLYGDGTVLRPGPDRGALHTLEAVKATAAQTREFYDRAHGVGLDADQEILNPDVVDGYSQVFVLVSGGHRYVTEADNPDESSDLVAFHETLHVEGRAEPYRPQRIAAVAWGSAPAEGARPWPWGTFDEGGCLILDADQATAVATSVPAHTPWLVGGREVLVVFRPLLPDESTCADLDYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK8</accession>
    <name>A0A7W7WWK8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="16241" checksum="7C6EAD0B4AF5DBD4" modified="2021-06-02" version="1">MPAVSARPGPERTRRWERRTLRITDFGLPAPEIGGEAYRTRLDERVQAAIAAGAVDLGTGDMFDALIEADRRTDQCRLTDEATRWWTRARQVLVRHERRYAHAERLRVDLSKALHAEVGKLEAIDRALAARRAEVERERGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWS7</accession>
    <name>A0A7W7WWS7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030676944" evidence="6">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="6"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="47341" checksum="7D39283741155B94" modified="2021-06-02" version="1">MVARGVLVPLALAQFVCSFAGSNMTVMIDDISRDLDTTVQGVQSAITIFLLVMAALMIPGGKLTDRYGRKVCLNLGLAVYGVGALLSALAPNLTVLVIGNSILEGIGTALLIPPVYILTTVLFTDGVARARAFGAVNAMGGIGAATGPLIGGLIATTLGWRAAFVFQALVVAVIIVLGRRHLRDPLPADPTRTFDVGGAILSAGGLSLVVLGILLADDDIRLTLVFLAAGALVLLWFFLAGRARERRGREPLLSARLFRDRTANLGLVTQNLEWLVLMGISLVVSTYLQVVRGHNAVQTGLVLTAATIGLLLTSLAAERLAKHHSQRVLVMAGFATTTTGIALFLALSAVSSGTWACLPGLFLIGLGTGAMLTPSVNIVQSSFPERLQGEISGLSRSVSNLGSSLGTAIAGTILVAGLARTPERSYALALTILAVIAAGGLVTAALLPRADKVTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT4</accession>
    <name>A0A7W7WWT4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="43488" checksum="F6CF6D6996A16A17" modified="2021-06-02" version="1">MSRRRHFGAENIEPTPVSLAKGHFDSWWRAVALCDEWRTHAMATGPADRSAAEAAISTLYRRAGAEPPVFIWVDSPRAALDLVPPGPIRSFYDYPRGVANDIADRLTGLRWRSARWDSSVWWGARPPQDALELLSTGSSPFTVARSHLLRPLGDLVRGRIAGYVRAELGDTVGLCWYGQQEADWLAWFSVLEVLRERAVHPEVMAGLEPWAVLARSCGWWWPRNGRCVISERPTAIHVDAGGEPLPHNAFGPAIEYADGFAVYAWHGTRVPAWVIDDPTPDRIAAERNAEVRRCAVENLGWQDFLDGGGLTLVATAPDPGNAGNLLSLYDQPVHWGRNQRLLVAVNGSVERDGTRRRYGLRVPGWFDDPVDAAAWTYGLTGDQYALLLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU3</accession>
    <name>A0A7W7WWU3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21461" checksum="09E5BF94D73D7458" modified="2021-06-02" version="1">MTGSAAFTAAGNWDGGFYELALELGPGGDARLGRALTALGKAAAVPNWYGSRDREPHEQVPVGCTLDSLRRYRHLRGIATLPAGTPVVCGLVAIREESGIDWLAFHLPLGALGSADPRVGGFPFEDDGTFTHLAWRQPIDNWLADIGRQVFADVGYSLGLIGLEASGEAYATDVTDGPPGHRGVGYLIPTDDEIRYWPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG3</accession>
    <name>A0A7W7WXG3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="24231" checksum="7B4576118EF5C6D7" modified="2021-06-02" version="1">MTSARTVLVTGGAGGIGRAIVSAFAALGDDVVLADVAGAAEAAAELGVRGVTADITDEDSIAKALDEAGPVDVLVNNAGLLTIHGGLLELPAADMLRILQVNVQGTFLITQQVARRMVERGQGGVVVNLSSIGGRQPTPGMGGYESSKAAVDALTRWSAIELAQHGIRVNAVAPGPVLTPMLAMGLPEGSPAREAWLARIPLRQLAAVEQVAAAVVFLASANAAHITGTSLPVDGGQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ7</accession>
    <name>A0A7W7WXJ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7186" checksum="7713F52A60557F75" modified="2021-06-02" version="1">MTRVPVVVSIGVDAELSDVIARLRTLGLVVDRVLDPLGVVVGSVDPDRLAALGTVPGVSGVERQRTVGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK9</accession>
    <name>A0A7W7WXK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7701" checksum="A88D35025E87C821" modified="2021-06-02" version="1">MLLAEHTRVSLDLVRDLIRPETGHQADDFTRDFVLDVDRENFRAEHPGIEGGAGLWWRRLADVSKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY09</accession>
    <name>A0A7W7WY09_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme oxygenase</fullName>
            <ecNumber evidence="3">1.14.14.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.18" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="24258" checksum="76CB143243F80B80" modified="2021-06-02" version="1">MTAVDEGFAARLRSGTRDEHERAERSVFVEALLGGRLGREAYAGLLGQTYLFYDVLENAGETWRDDPVVGAFVIDGLLRRDALARDLAYLLGADWRVEPLPATRAYMDRLHEVCFTSRGAFVAHHYTRYLGDLSGGQVIHRRMRDIYGFEDDGVRFYVFDQVAKPKPFRDHYRALLDAAPWREGERDELVEEANVAFRLNRAVFEDLSSVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY61</accession>
    <name>A0A7W7WY61_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate hydroxylase</fullName>
            <ecNumber evidence="2">1.14.13.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018658">
        <property type="term" value="F:salicylate 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="274"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="387" mass="41755" checksum="4D24F875DB763F09" modified="2021-06-02" version="1">MTDILIVGGGIGGLATALAVAGHGHHVVVLERAPRFAELGAGIQLGPNAFHALDRLGVGDRARDRAVFIDELRFMDGTTGEKVAAMPLTGEYRRRFGNPYAVVHRGDLYQVLLDACRATSDIELHADQPVVGYTQDAGSVTARTASGSTFRGSALLGADGIRSVIRGQLVGDGRPRVSGHTIYRSVIPMDRVPEELRWNTVTLWAGPKWHFVHYPIGGGEFLNLAATRDDGALEEISGEPVAKELVPLRFPGLGDTARRLLDLGEDWRTWVLCDRDPVRRWTDGRVALLGDAAHPMLQYAAQGACQALEDAVVLGEVLDGGGSEVPQRLAKYAASRRDRTARIQLVARALGSALYHPEGAEALRRNEMLAALSVADLYDQVAWLHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS3</accession>
    <name>A0A7W7WYS3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YhaH (DUF805 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35045" checksum="A4D102FFC901247A" modified="2021-06-02" version="1">MAVLDAPPAATTGVRAAVVRWHRPLIVYTASMVLVAVASAVGILVDDRQLLGESVWFKPFKFGVSLAVYGPTLAWLISLATRGGRVLWWMGTVTAAMGVGETVLLLVQVVRGVPSHFNAATPFDTAVFAVMGLMITVFWSANLVVAVVVLRQRFADRPVRWALRLGLLIALAGMAAAFFMTTPTPDQMEALRAGESVRMIGAHSVGTSDGSPGMPLTHWSTVGGDLRVPHFFGIHALQVVPAVALAPAWFARRTGRLATGRTSRLASETTRTRLTVVAALSYAGVFVLVLWQALRGQPLVHPDTTTLVAAGALAAVTGIGIGIALRTTAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ19</accession>
    <name>A0A7W7WZ19_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose 6-phosphate synthase</fullName>
            <ecNumber evidence="2">2.4.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="479" mass="53402" checksum="0821071DFCA2A729" modified="2021-06-02" version="1">MSSGIGENGADFLVVANRLPVDLERLEDGTQRWKHSPGGLVSALEPFLRSHSGAWVGWPGVADADVEAFSEDGLQLHPVALSAADVADYYEGFSNGTLWPLYHDVVAPPAFHRRWWNAYVRVNQRFADVTAKVAAQGATVWVQDYQLQLVPAMLRELRPDLRIGFFLHIPFPPVELFMQLPWRTEIIRGLLGADLVGFHRPGGAQNFLWLARRLVGLEPSRGAVGVRTRPGVVQVGDRTVRVGAFPISIDSTRIDALSRDKEVQKRARKIRADLGNPKRILLGVDRLDYTKGIDLRLRALHELFADGRIDPGEVTMIQLATPSRERIEHYKQMRDELERIVGRINGEFSTVGHPVVHYLHQSVDRRELTAFMSAADVMVVTPVRDGMNLVCKEYVATRHDLGGALVLSEFAGAAAELTSAFLVNPHDLDGVKNALEAALKLDPAEGRRRMRALRRQVLTHDVDRWARSFLEALGTQTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZJ2</accession>
    <name>A0A7W7WZJ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20056" checksum="61EED7A3EF73252A" modified="2021-06-02" version="1">MGQLSFFSAEARAPRVGDLAGLLCGPGRALGFARGRAARVSVALDEPGRGPALVSAMAERGVEARVGTCAEKGNPEVTTAFRTDLTGLAGQWLRSGTKVVPDDFAPDGGVLRLWALAAGRWVESGYVLGLDPDAPDTHEPLRKALATAGLPATLSAPKAGGPALRVNGRRRLERLAELVGRAPTGVTGRTWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZJ4</accession>
    <name>A0A7W7WZJ4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="DUF262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="DUF262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF262" evidence="2">
        <location>
            <begin position="54"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="43639" checksum="5054CA7D7C1AA31A" modified="2021-06-02" version="1">MSDFDLKEIREEHFEDEPTGIEVEHDEEPRATRASDREEIRVSTKQFSIRQVMDQIDDGDLELAPDFQRNQVWKPWQKSGLVESILLQIPLPAFYFAETPEGLLRVVDGLQRLSTVHSFMRQEGFALTGLEYLESEVGGKTFRELELPWRRRMDNTQIFAHVIDPKTPARVTYDIFKRINTGGTPLKPQEIRHSMSAQRSRDFLKSCTALPEFHRATWGSLRNSARMDDREVVLRFCAFRLLGVDGYLESTRRSTEAFLLEATKWLDDPQMVDDAALHGLRQDFSRAMINAQLVFGSYAFRKWPEGNEAHSPINKALFESWSFALSQLTPEQATKRGPQIVAAARKLMTDDTKYLAAVTVSTGDPAKVELRFRVATVLVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXD8</accession>
    <name>A0A7W7SXD8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20869" checksum="E5D550C29BB6FB62" modified="2021-06-02" version="1">MDMENAPNEELLTLARQGDQRAWTVLVHRYGRLVWSVPRSLRLTPHDAADVSQTTWLLLSEHLTRIDHPDRLGAWLVTTARREALRVLRLRGKEEPLDDWNPRDDRPSPEEAAIDTDTGRLLWHAFTSLTDRCREILRLVAYAPDLTFTQVATAVGIPPGSLGPTRGRCLQVLRRRITPEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXK4</accession>
    <name>A0A7W7SXK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate ferredoxin oxidoreductase subunit beta</fullName>
            <ecNumber evidence="2">1.2.7.11</ecNumber>
            <ecNumber evidence="2">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="2"/>
    <dbReference type="EC" id="1.2.7.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="67"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="37616" checksum="219AE60A6A6C10B9" modified="2021-06-02" version="1">MTAIDLGLPGLAGVPAADEPQKAKDYKSDQEVRWCPGCGDYVVLNAVQSFLPTLGLKRENIVFISGIGCSSRFPYYMNTYGMHSIHGRAPAIATGLAVARPDLSVWVVTGDGDALSIGGNHLIHTLRRNVNLKILLFNNRIYGLTKGQYSPTSEEGKITKSTPVGSLDHPFNPVSLALGAEATFVGRAVDSDRKGLTEVLRQAAEHRGSALVEIYQNCPIFNDGAFDVLKDADEAARRIIDVVHGRPITFGKDGEYAVVREGFGLAVAKTSEVAPQDVVVHDAEDLNLAFALSRLSTQDLQHTVTGVFRSARRATYDDAARAQVEQAQAEKKADLAGLLRGKDTWTVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXP5</accession>
    <name>A0A7W7SXP5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">F4559_000252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10836" checksum="0C234823FFE01D76" modified="2021-06-02" version="1">MSENNEVTTTEVRGERKVREGLVVSDKMDKTIVVAVEDRKKHRRYSKVMRSTTKVKAHDEQNAAGIGDRVLLMETRPLSATKRWRLVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXU4</accession>
    <name>A0A7W7SXU4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14553" checksum="943114D39C168423" modified="2021-06-02" version="1">MGVRAADIAVGDSLPPLTLRITRADLVRYAGASGDLNPIHWSERFAVGVGLPGVIAHGMLTMGMAARIVTEWTGDPGAVLEYGVRFGRPVPVPDDDLGALVEVTAKVTKVLDDGTFKVNVTAAFEGKSVLGGASARVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY56</accession>
    <name>A0A7W7SY56_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16032" checksum="9C4FFB60DE3C181A" modified="2021-06-02" version="1">MEPVEINAGEFYLRQWRADDRIDDREALVAAGRCADRGTAGEFVADRTRRWDDDSVCSWAVCDQLTGTAVGEVALTAEGGLTCWTTPARRREGIARHAVSAVVGFGFGFLDLPRIDAVPHDDAGLRLAHACGFEPDISRGVWTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY86</accession>
    <name>A0A7W7SY86_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="38260" checksum="414DEB515BDBE2A4" modified="2021-06-02" version="1">MARPLKVLIDGTPLLGHRTGIGRYTAALAEELASTDDVDVRAVAFTLRGWRGLRTVLPHEVVARGLPVSARLLRQAWLRFPFPPVELLAGPSDVMHATNFVLPPSLRAGGVTTIHDLAFLDAPGDLPPSDRRLPELVRQSAHRAAVVCTPTHAVAATVAERLGVAPDKIVVTPLGVDPAWFAAQPPSEALRSRLHLPREYLLFVGAGGPRKGLEPLLTAHASRPELPPLVLAGPHRSGVDGRVLRTGYLGEPDLRAIVAGAAALVLPSRDEGFGLPVLEALACHVPVVCSDVPALREVAGGHATHVPFGDTEGLADALTVAVETTPDPVAQAARRAHAAEFTWRRTAEKTVEAYRRAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYM0</accession>
    <name>A0A7W7SYM0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="4">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020803">
        <property type="entry name" value="PKS_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00828">
        <property type="entry name" value="PKS_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_MT" evidence="3">
        <location>
            <begin position="135"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="44952" checksum="5274FE20B0E1A17D" modified="2021-06-02" version="1">MFRQAVGGDATVRFSAYDGSSAGPSDADVSVEVRSPEALSYLASAPGELGLARAYVTGHLEVVGDLYAALGHLSVLSLSAVSWANRVDLLRVVGRQLLSSRVEIPKQERRLRGLRHSKTRDQAAIAHHYDVSNTFYEYVLGSSMAYTCAVYPTETSTLEEAQHAKHDLVARKLALKPGMRLLDVGCGWGGMVMHAAREYGVRALGVTLSRNQAEWARKAIVAAGLSDLAEVRHLDYRDVRESRFDAISSIGLAEHIGKAKLPGYFRFLARKLRPGGRMLNHCITRSGNRERARTGRFIDRYVFPDGELVGPGHIVSVMSDNGFEVRHEENLREHYALTLAAWGENLEERWDDAVSEVGTARARVWRLYMAASRLGFERNAVQLHQVLGVRLDGSSSRMPLRPDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ20</accession>
    <name>A0A7W7SZ20_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="24637" checksum="3F720A8C8506F5C2" modified="2021-06-02" version="1">MPSPLVAYDDPDEAAWLVGNVGSRRRSATGDLLTTVGMLVPRVFPVYLRVLFPFDGPADEATVSWREVAARAGIGLTVEMSCGRLWDALSPSDRESLGRPWDGHQPPGVSHVLSEVLARHTTTPGRCVFAVWDGRGGLAEHHTSGTAIDHHGRIWFLNAGTVADAPEGLDRNVGDSRIPPDLWWPADHAWFAGTDLDSASSYVGCGEEAARALAAAGLELLPVRVDDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE7</accession>
    <name>A0A7W7SZE7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="40619" checksum="F66C97696A417EA5" modified="2021-06-02" version="1">MTAPHTTPTPGWLVAVLGALLLPLAGGAFVLSFEQQLPVMMLGGWGPRTAPLGPVVLDLAASAGAVMHVVARDRQVRAWGLGLLVGATGLSVVVNLAGHSIAVPGGTTRAVMPDSMAGWHLPGRWDLVVMLLSVAVPIMVGVLVHAFGAVLRAWLDSRSGRVGSGTRLAVGPVGYPTGRLSDYPTHVEPADSAKPTRPDPVADSPADSPVPPDPTGRVGYPTRVAESGTRLEPDSGPDLRESGESGSRPDPARPVESGKPTLPTAREPDPTRQADCPTDRPDPVADSPDPTGEPEADPTPATRLADPTQKQSTEPDPTRPDSDADPTDPTLDGQLDAARRLIESGRLQPGARGSYTEQAVREALSVGAARAREIREALNADLRHGLRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZI1</accession>
    <name>A0A7W7SZI1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="5997" checksum="0F51F415D54A7B68" modified="2021-06-02" version="1">MTAAEQFASVAALDAATHHAVEVLPPLDPPYQGELDVPTRPTVSPWFRKPNSLGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZI2</accession>
    <name>A0A7W7SZI2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="10" type="ORF">F4559_000566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="43021" checksum="02E19D5BD7711346" modified="2021-06-02" version="1">MTQQWSAPTADGPVHATVPVPGSKSITNRALVLAAIAAGPSTLNAPLRSRDTLLMAAALRSLGVGVEDGPDGSWSVTPAPLRGPVDVDCGLAGTVMRFLPPAAALAAGDVRFDGDEHARVRPMGTILDGLRGLGVDVEGDALPFTLRGKGGVPGGEVTIDASASSQFVSGLLLSGARYEGGVTVRHVGPPVPSLPHIEMTVATLRAAGVTVTVGENVWRVEPGPIAGRVWDVEPDLSNATPFLAAAAVTGGSVTIPGWPAETTQPGGAARDLFTRLGCEVVTDERGLTVRGPERLTGIDVDLRDESELTPTVVALAALADGPSRIRGVAHIRGHETDRIAALVAEVNRLGGAAAETADGLTIDPRPLRGGQWQAYADHRMATAGAIIGLVVPGVTVDDIASTGKTIPDFPGMWSAMLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ8</accession>
    <name>A0A7W7SZJ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="24243" checksum="753BFA35E85F5EF0" modified="2021-06-02" version="1">MGQHSGIGVLDKAVAVLNAVAKDPCGLAELCNRTGLPRATAHRLAVGLEVHRLLRRGSDGRWRPGAALAELAGGATDPLLDAASSVLPRLRDITGESVQLYRRDGTQRICVSSAEPPSGLRDTVPVGARLPMTAGSGAKVLAAWADPGTQRSVLADAVYGERTLLEVRRRGWAQSVAEREPGVASVSAPVRDSTGAVVAAVSVSGPIDRMGRRPGARWAADLLAAAEALQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS7</accession>
    <name>A0A7W7SZS7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">F4559_001332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="384" mass="40760" checksum="7308AEEE82931687" modified="2021-06-02" version="1">MTDGVLLGMPALPPPVLSQRRKTRQLMVGSVGVGSEFPVSVQSMTTTLTADVNATLQQIAELTASGCDIVRVACPSQDDADALPAIARKSQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKKFDDKVKEIAQAARDHNTPIRIGVNAGSLDPRLLEKYGKATPEALVESALWEASLFAEHDFHDIKISVKHNDPVVMVRAYEMLAEQCDYPLHLGVTEAGPAFQGTIKSSVAFGALLARGIGDTIRVSLSAPPVEEVKVGHQILQSLNLRPRKLEIVSCPSCGRAQVDVYTLADQVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVKGKVIKTVPEHKIVETLIEEAMRLAEEIGDDAAGEPVVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU5</accession>
    <name>A0A7W7SZU5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CP family cyanate transporter-like MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="51"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="431" mass="43685" checksum="A42C60F20110F382" modified="2021-06-02" version="1">MAIQRTEPDRTPSSVHPATDSPISATIATLRSDRSTGSLRSDRSVALVGSTLLAIGVALAAANLRPAVTGLASVLGDVRSSLGVSTAWTSLLTAVPTLCFGFAAFLAPWLGRRLGMARAVGLSLLVLTIGLVLRVVDGPLVVLGGTFVACAGIAVCNVLIPVVVKDSFPGRVGLVTGVYTAALAAGAAVGAAFTPTLESVLGSWRLAVGAWAFLSLAALLVWLAGARHGVTVAGAGTKRVPVTRSLTRSPLAWVITVFFGLQSLLAYTVMGWLPQILGDAGVDRTTAGLLLAITMVLGVPVSLIVPPLAVRRASQSGLVAVLGLLSVAGVLGLALVPAAAPGLWVVLIGVGMGMFPLALVMISLRTSSTADTARLSAMAQSIGYLLAATGPFAFGLLRGATGDWTLSMLVLVGLLVLLTALGVVAGRPRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY8</accession>
    <name>A0A7W7SZY8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino-acid N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="18474" checksum="17362D46ABFDEDB4" modified="2021-06-02" version="1">MNDSITVRRARTGDVRAMKALVDQYAGKVLLAKALVTLFEDVQEFWVAEEDGVVLGCGALHVLWEDLAEIRTVAVSQDALGRGIGHRIVAQLISTARELQIRRIFVLTFETAFFARHGFVEIDGTPVSPEVYEEIMRSADEGVAEFLDLSYVKPNTLGNSRMLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T063</accession>
    <name>A0A7W7T063_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">F4559_000209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="68"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4962850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="30449" checksum="E8C595282520E2F5" modified="2021-06-02" version="1">MYKHCNGVRTVLLLGALSALIVVVGGLFGTTALVVGLVVAVGVDLYAYFNSDKLALRALNARPVSEVEQPVVYRIVRELAHAARQPMPRLYVSHTAAPNAFATGRNPRNAAICCTTGILELLDERELRAVLGHELSHVYNRDILVSCTAGALAGAVSALAGLALFAGVFDEDGSEDRANPFAVLLAAVLGPVAAGIVRLAVSRSREYQADAAGAELTGDPLALASALRKIADGTRAAPLAAEPAVVAQSHLLIASPFRPDEQRARLFATHPPIADRVRRLEEMARRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A3</accession>
    <name>A0A7W7T0A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ornithine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="PTHR11482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="240"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="38227" checksum="F95A96085DB0D4D6" modified="2021-06-02" version="1">MDLPTVRDRFTALRDALPGVGIFYAVKANPTPEVVELLAQQGCRFDVASPNEIDLCLDRGARPETISYSNPIKKARDIAYAYERGVRLFVSDSEHDVRTVAEHAPGARVMLRILVAANGSTYPFGKKFGCTPEMATDLLRLAAELGLVPLGVAFHAGSQQLDPNGWDAAIADAALITAKLRAEGVELTTVNLGGGLPAGYREQPRPVADYAAAITASLRRHFGDAAPEVMIEPGRAIVAEAGLIRSEVVLVAKKSYADEHRWVFLDIGRYGGLAETEGEAIAYPLRTDKDGGPVGPVVIAGPTCDADDVLYQSTHYELPLDLRAGDHVDLIGTGAYTSSYSSVAFNGFPPLATYCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C9</accession>
    <name>A0A7W7T0C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21410" checksum="EA2D1DA737B8D18E" modified="2021-06-02" version="1">MSTSTWTTDSVTTERLTLRPWRVDDAQAALDVYGHAEVTRWLSPDMDRVPDLAAMRLLLQQWSAEGARLPAPAGRWAVRRTSDDCVIGGAVLLPLPPGNEDLEIGWQLRPDAWGNGYATETTHALAAWAFSQNVHEIFAVVRPGNVRAAATVRKNGMHWVGETTKYFGVELQVFRLRAADLDPAAPTALRPPGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N2</accession>
    <name>A0A7W7T0N2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7351" checksum="657EA7BB9330984A" modified="2021-06-02" version="1">MRWRKSTRSSNVANCVELATTPDALLVRDSKRPDGPVLAFPRAALAPFLRTARGGRPDFTVRSGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0P1</accession>
    <name>A0A7W7T0P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="26994" checksum="4E30EE20639E7051" modified="2021-06-02" version="1">MTERLADHRWAADFPADAGLLGAVRAGLDAWLLAVGLSEDDRYDLVIAANEAMSNAAEHAYGPARAGVVRVRAELCPDGSLHVVVSDDGVWRVPPIGLTDRGRGLLLMRENADEVHVERAPTGTTVELVFAAGHTTRGTAAGTVPAEPVEVSERDGLVEVVVRGDVPARAGPALRRRILTAARGGSVPVMVDVRGLGTHGEGLIRGLVAVAEAASAAGNRVVVRLGTDDVVADAVRAALVASGVDQVVDLVAHVDRWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V1</accession>
    <name>A0A7W7T0V1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular small neutral protease</fullName>
            <ecNumber evidence="3">3.4.24.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Snapalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031479203" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="35"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="18295" checksum="D9DF6EE6CD6C689A" modified="2021-06-02" version="1">MNRKFARLALGVLTTALALVGTSTATSAAPTAAAARTVYYSASGYSAEADQAAQIWNSRVPNLRLVRGGNATIRIAATNGGGSRAYPCGTGCATIYIDNRDVQAGNYALRIVAHEIGHGLGLPDTYNGICSYLMSGGSAGTSCRNTNPNAQEANRVNQLFAGGFLATEAGTPGVYARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V8</accession>
    <name>A0A7W7T0V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane-associated protease RseP (Regulator of RpoE activity)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_001331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="10">
        <location>
            <begin position="10"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="43269" checksum="3BE4976A34A9475B" modified="2021-06-02" version="1">MAYFLGILLFAVLIGISIALHELGHLATAKMFGMKVTRYFIGFGPRIWSFRRGETEYGLKAIPAGGFCEITGMTALEEVSPQDAPRAFYRQKTWKRVIVLAAGSITHFIIGFVVLYVMAATMGLKNIADTPVIAEVGDCVQTNADDKCEPGEPAPAKAAGFQVGDEIVAVAGKDTPTWSDVQLATRDRSGPTEFRVERDGTELTLTADVVRVTRELLYQDGHTEKKEVGAIGVVRQSDFTYTPLTAFGGATEFTGQMFQNTWHGLLKFPEKIPAVIKAIAGGERDADSPVSVVGASRLGGEAVEKGIWPLFWFMLAGLNFFVGVFNLLPLLPLDGGHIAVNLYERVRNWVRKLRGLPDGAPVNYTRLLPLTYFVIFVGGAVTLLTVTADIVNPIRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X6</accession>
    <name>A0A7W7T0X6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031184572" evidence="3">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="237" mass="24682" checksum="BE9E3C849FBF5FFC" modified="2021-06-02" version="1">MRISVLVVLVLLAVAAPGPARAIVGGHPADEPWVVALFDPGRNLFCGGALIAPDKVVTAAHCTVERTALATLDRQRITVVAGRPDLDQPVGHEVEVASSWRHPDFRSVAEGDDVAILTLAHPLPYRTIAVGAAYTGPATVHGWGRTGELAPASRVLRAVDVPVLDDGTCRKADSVHNPAKMLCAGYPEGGKDACEGDSGGPIVQDGALIGVVSYGRGCARPGEPGVYTRLAAYLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T155</accession>
    <name>A0A7W7T155_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031481692" evidence="3">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="30045" checksum="1E66C1A8D7B38BBF" modified="2021-06-02" version="1">MGLLLFCGIFLGTAPAQAVTGAVTANATVDGRPVGEDTLLLDPAKTAKISVTVHNGTSDALHVKTIRLAGTALALTFFAYDTALPFDVPAGQSVTRSFVLDLADLDGQATGLLPTELSLLDGERDAIAVIDTTGDVRGSAWSVYGIFGLSVLALTLLAWAGALFALARRRLPANRWQRATRFLPAGIGTGLVAVISLSVLRVIAPSPAAEIPFILGAAAVALALGYLTPHPDDPAPETEPEPGSTTRTTVSTTTTATTPATTPATATLRTTTANVDPEATVRLTRPMPPGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G8</accession>
    <name>A0A7W7T1G8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">F4559_000929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7701" checksum="F164141797D43E0A" modified="2021-06-02" version="1">MKTGIHPEYVTTEVTCGCGNSFTTRSTKTSGSIHVEVCSNCHPFYTGKQKILDTGGRVARFEARYGKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q1</accession>
    <name>A0A7W7T1Q1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18377" checksum="AC6B40B38329356C" modified="2021-06-02" version="1">MTRHTLSVLVEDKPGVLARVAGLFSRRGFNIESLAVGRTEHPDISRMTIVVSVEDLPLEQVTKQLNKLINVIKIVELEPTAAVQRQLLLVKVRADATVRSQVLETVQLFRAKVVDVSPEAVTVEATGTSEKLDALLRMLEPYGLREIVQSGMVAIGRGARSITATAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X6</accession>
    <name>A0A7W7T1X6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="944"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1051" mass="112037" checksum="F80422A0A03E4D5B" modified="2021-06-02" version="1">MTDPAARKRALLAERLRARASTPTPYPLSFGQQRLWFLDRFAPGTAVYNVPIAVRLRGPLDVDALRSALDLLVRRHAALRTTFPDSGGEPVQLVAPTGAATLNLVDLPADDRDARAQRFADERGAVGFDLHRGPLFVADLGRFAEDDHVLVLTLHHIVSDAWSLAVLLHDLGEAYAGRGEALPPLRLGYPDFAVWQRDQVTAHAQDHLAYWADHLAGAPELLTLPTDRPRPAVATYRGALYTATVPPETLSAWEEVGRAHGATLFMVLLAGFAARLGRLAGQDDVVVGTPVAGRAHPDLEHLVGFFVNSLALRAHVGGDPTFAELLGRVRESTVEGLAHADLPFDRVVEHLSPHRALGHAPLHQAQLILQNTPPTTISLPGLEITGLAPDPGVSKFDLTIAAEYRAGGLALGVEYSTDLFDEATVVEFTDRFVALLTAAAREPHRRIGDLDALSGVRRWEVLEGWNATDLALPEAASALDLISGDPDAVAVSGVDGALTYRELDARAARIAGLVRGSRLVALCLPRTPDLVAAVLGVWRAGAAYLPLDPSWPADRLALMLADSGADLLITDGDTFGFTGRVAAPTDDAEPLTEVVPGDLAYVIYTSGSTGRPKGVEVPHRAVVNLLVSFRDLLAPAPGDRLAAVTTLSFDISVLELLLPLVSGAEVLVVPDAGDGPALRDLLTTRGVTMLQATPATWRLLLAAGGVPETVTTRVCGGEALPRDLADELITDSALLWNVYGPTETTVWSAAGPVEPSPAPVVIGPPIGNTRLYVLDARMEPVPPGVVGELYIGGAGVAVGYRGRPELTASRFVPDPFAATPGRLYATGDLVRQRGDGTLEFLGRADHQVKVRGFRIELGEIEAALRDLDYVREAVVVARDERLVAYLVGTDTWPRARTALAERLPDYMLPATAVVLDALPLTPNGKVDRKALPEPSWTSHVDRVAPREPVEEVVAEIWREVLGVTELGVHDDFFALGGHSLLAAKALARVHGAFSVSVPIGRLFAAPTVAGLATAVRELEDEPGQVAAVAELRVRLAGLSDEEIAALLEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T201</accession>
    <name>A0A7W7T201_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26612" checksum="A2887FAF1B4C5FE4" modified="2021-06-02" version="1">MTASIQSPSLSTAGPASGSTWFPGPVLGGLSLTVAPLLLLAATLLRSPFDFFYKQQLAAFGSDPTLMVTAYTLFLAGTVALWPGIVSLVRSIAHTRPTLARWAGGLVVTGLLARTFHAGVDQAAFSLARHRGVEFATAQVGLAYQDEHLFSYLSFTIMFGWFVLAFAVYRSGHFTGVVGKIRAVALATMGLLPLGVLKGTELLSIVGTVGLCVALLPEGVRLLRTVSRPTPRAAAMAALTVVGLAAFAYLSTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2P0</accession>
    <name>A0A7W7T2P0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6292 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046259">
        <property type="entry name" value="DUF6292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19809">
        <property type="entry name" value="DUF6292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6292" evidence="1">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16195" checksum="13097F3ED58F516B" modified="2021-06-02" version="1">MPVIRHADDSADDEVRPELAEHGLRHYTARIASAVGAGAEAAWCEWADAPSAYIALDHRLSDYPDRDAALIWAAERGWAVAVETGCGEDLLITAPLGGDVLPAPETVATWVRAVLAGKHADTPRRPCAAASTDVIRRLANWAGHEPTLDGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T306</accession>
    <name>A0A7W7T306_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="533" mass="58643" checksum="AFC5E82C1AF7CC10" modified="2021-06-02" version="1">MERISYPRTPHLPWSPGVSRDDVRVADLGAWAGGEVVVTEKLDGENTTLYRDGSHARSLDSGHHPSRSWVKALQGRVGGFIPVGWRVCGENLYARHSLAYQELDGYFYGFSVWDGDECLDWDSTVGFLRGLGIPVPTVLWRGVFDEKMLRRLKVDTLVSEGYVVRPAAGFGLGDFGRTVAKWVRPAHVRTSTHWMSAPVVPNGLGPGARYWDIRSGAGFELPDGDQAAAEKVADELRPGEGRLVGVLAAAYHRRPRGRVVLDLVDRVGMGTARRVGDVVGLHRLLHHDFPEDQRRSGLLRFATAVDLGVLHAVAGAVATGGARDQVAWSALHAEDLPRWPEFAGSARRLAEARDLVIRDGRAFGPEEADAATWRWRDRDCPEFFHLVGISGSGKSTFAAKSDVDEVVSMDDLRADAGDRADQRSNARVLGVALDRLGAALRHGRSALWDATSITARQRDAVQAVARRHDATRTYVVVLASEAEIRRRNANRADPVPDHVLSAQIRRFDPPYAWQAHRIRYVDATGTVVADAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T362</accession>
    <name>A0A7W7T362_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="589" mass="61802" checksum="E1C6F4C5C19CD8AD" modified="2021-06-02" version="1">MTGPGTFTVELLGPVRVRRDGLEVDLGPARRQAVFAVLAAQAGRAVSREELVAGVWGDAAPATAEAGLYNHVSGLRRALEPRRSRRSAGGIIVSTGGGYLVDVAPDALDVHRFERHRAHARTLADAGALAELDRALALWRGAAFSGVPGPFALAQRARLADLRLATVEARAGLALAAGRVADVIAELSGLVVEHPVREGLRALLITALHLGGRQAEALRAYEDTQRVLVDELGIEPGPALRTARQRVVGDVARPPRTPSVEVARTGIVGRHRELDLLRGPPGRALWLDGEPGIGKSALLAAGLADRRVARVTGDEVDGRLPLRVLLDAVDGRHAEDLCADGPFVLVVDGLQWVDEDTVRFWTDLLPHTTRRPLFLIATARPVPRRADVARARRAVADFEGGEVVGLGGLPADDVVALVTGMVGAPPGPVLRGLCEQAGGNPRYVTELVDALLRDGALAFRDGVVETGRDLSRAVASALTARLDFLSPGTVTVLRWAALLGDEFAPGDVATVAGELVSDLVAAVDEAAAAGVLADAGPRLAFRHPLLRRALYRGMPAAVRTALHGQAARVLAEAGAPADVVARHLADGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T380</accession>
    <name>A0A7W7T380_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme chloroperoxidase</fullName>
            <ecNumber evidence="2">1.11.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.10" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016691">
        <property type="term" value="F:chloride peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="29571" checksum="D481C25422FA9A3E" modified="2021-06-02" version="1">MTTADGARIFYKDWGEGRPVVLSHGWPLNADSWEAQQLFLAHNGFRAIAHDRRGHGRSDQTWHGNAMDTYADDLAALVDALDLREVTLVGFSTGGGEVARYVGRHGTSRVAQVVLVSAVPPFMLRTDDNPDGVPGEVFDDLRAGSLADRSQLYRDLADGPFFGNDRPGAAVSQGIRDAFWRQGLEAGHHNAYECVAAFSATDFRADLDAFDVPTLVIHGDDDQVVPIDVGGRASAARIAHAELIVYPDAPHGITDTHKQRLSDDLLAFLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3K5</accession>
    <name>A0A7W7T3K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12512" checksum="BC9CDD5B7BD7C80D" modified="2021-06-02" version="1">MTYEPATEPNDLGRYFIERGNAGDVDGLVALYEPDAVLAFPPGNLATGHAQIREVYERFLAARPVLTQGRQHAALTGGDLALTSSTLTSGDVTVEIARRQPDGSWLWAVDQPVFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S6</accession>
    <name>A0A7W7T3S6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031314119" evidence="1">
        <location>
            <begin position="35"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="92"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="550" mass="58938" checksum="1778D6E452F5ED2D" modified="2021-06-02" version="1">MSRPRHVTLAGRASRMIVGLASVVVLAACGPGVAAQGPGSSEPKGGGAITFLIDSLGDTWIPNNSAISSFQGHIWGHVTDKLVYVDDKGAASPWVAERWAQNPTATEFTLHLRSDVTFSDGTPLDAAAVVANLDIWSKGDPTRGINPIGLFPKTYQRAEAVDAATVKVFFAAPTLGFIPTLGYHGSILISPKTLALPATQQADLSNDIGSGPFVVESWKQGDSVVLKKRPDYDWAPAALGHQGAARLDKITYKLVAEPSVRTSAVQSGQADVAYNPSPQELASFKAQGFTTATPRYLGFVNGYAINTKIAPFDDIRVRQAIQHGIDRKEILSTVYTEDWLPAQSLFQSNVPGATDHSADFAFDAAKADRLLDEAGWVKGADGVRAKDGKPLTFTLYANPYLATSKSVDELVAQQLGKRGFKVEIQAFDVVTFGERVKVNSPSVALYEVTRSFIDAGTVAGVLTDANKGENWFGLGQSDQKLVGLAGSVARAETVEARSPVLDELQGHVLRQGYFVPLTQIVQRLYLQSPKLHGVSYNGIAYANYYAAWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V0</accession>
    <name>A0A7W7T3V0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0716 protein FxsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17221" checksum="CBFF6FBA4539B2FB" modified="2021-06-02" version="1">MRVFAVLLIGLAVELTTLVWAFGAWGFLTTLGLLVLGGVVGSVLIRREGARTMAAFTEALRSRREPHQEIADGVLIAAAGLLIVVPGFLSDLAGLFLLFPPTRRLVSRRLARGAERRAATITLNQRYGRPPTSGGVVIDGDVVDVRADDHDGRPNRPELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T456</accession>
    <name>A0A7W7T456_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="31330" checksum="1E82550D7BD15F6C" modified="2021-06-02" version="1">MIENSAEGLYRLASEVTVAVTREDHHQDALSRYAVEPGQERHVAAELGWCVVAAGKHRGERAVEVRIDGLRVGELTPLLSRRYEPVVDQVIASGTRPGCAAVVVRSTRGLEVRLRLPREGTPVAGYPTVPATPVMVPPRPNFFVRHKPLSIAAALVVAVFMIAAIAGKKDDRKTAAPAAATVTTTSVAIIPTPTVTATHVTTAPPTTTAAPTTPAPTTVVPPPVTTQPPVTQAPPPVAPAPTQPAQPDCHPNYSGCVPIAKDVDCAGGKGNGPAYVEGPITVIGKDVYDLDDDKDGIACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N5</accession>
    <name>A0A7W7T4N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="544" mass="59546" checksum="1194818750A08C57" modified="2021-06-02" version="1">MTGFDPTPLRRVCQGVVAGLPGEVRERFAQAYESPDDLVDAMVAAGDRAWRHLDKRGRSVPPERYQALALALLSVRNGPVDVQTNLTNVAAAYDRLLPLGELPLDVAVQCRLTTPELAARLVVAYRVAQVVRARRPGTQPLFVDMVTCAVVGFADAADAADIVDRVLDRANPLAAAYRYRRSLDPNPRAGVQGGYTDLVGQIAGYRVAVAEARGYRSADVEATVDEYAERVADDLHRGLTRPPAVGRADEPDSLVTLRGFAGFVAADHADDGREARTLFRLLAYRLPGEVRPERWKRDVPVAPDEARDRGDLPVPGDDGTPDADLVADAVLAELYADTGAADTAAIDEWLLARRAPDGRDDLLVLVDRVRRVDRLLSRPGPDKPRPGVVDPRVRQALRDRIADALTLRLRGTEIAQHILPPLWTEREYVVHFAEARLRVDLPPGTGKLAKAALLANAVVRAPAQPVHRAADPDRRDDCACGTPDRTPPAPAAVCPHRTWWEAGRVEDYTTLARVSGLASEDAVRNQLARHTGFWREWVEEIRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N7</accession>
    <name>A0A7W7T4N7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="353" mass="39195" checksum="E5E4D0E1F400F228" modified="2021-06-02" version="1">MTVEDLRRRHVALLRDRRVVDGLRPGADRSDTRYHTWTQVASEPAAARLDRLLDLRRRPGPYRSARLHDRQRGLDALHPELLHLARRAGWTLTTPTLAAVFPTGTLDGICLPVPGRGVLVLVDSGLLDLVPNVLTVMTGALPHYGSPPLLSGEQATWALTEMFNAYLYGNGAVGPHALPELSGQRRALVGALSRRTVQFVVAHELSHVVAGHLVHARRWTDPTTPVGALDSLSVGWPREHEADRTAATIMSHTLDDLTQRDVEVHEPYLVGAMLLPLFLHEMTDRLAEQFDLAVPFAGSHPPPVRRIQALVEHLSDRVRTRRALDLAADVATWLEDRLDAVSEWFRQVRVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T514</accession>
    <name>A0A7W7T514_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031000201" evidence="1">
        <location>
            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="38310" checksum="D0D1B7C6057D3FFC" modified="2021-06-02" version="1">MAAVVPVLMLVACGSPTPEPAPHVGTTGAPITDGPLYDPPKSFADQGVSLTKDRKALVGNEAAFTITAKEGSSSDAALNVRAIALVDGVERWVAKTPVERGPGDPIRLSGGQVVWAGLARGSNGFDLVVGGLDARTGNQTWTARTAYPGGASPQETRTSVVAANDAFVAVVAGSFGALVDVRASSATALPAGFVPVGLDDRIVVGLRTSGAGTIAQGLDVGTAKVRWTGSAPVRDLRAAVVVPGLAQFVEDVPAEPRTLLLGTGDGGVRATLPESPSCSPAAQDVVVCVSYHDVTALDLAGTRLWTLPDTSTGRLNPEVAAVYAGLVYGRAHGGTILDARTGRDVATGVGRVPDAIVPGYGVRRDDMTGLTSYRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M6</accession>
    <name>A0A7W7T5M6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TipAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TipAS" evidence="6">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13348" checksum="C225D895C6A175B5" modified="2021-06-02" version="1">MTPTWREAPWCRAWTSAPSAPSPNRLFYRESDFDPGTVAATGTGTAPSDPAVTSLAERHRQHLEHWFHDRDHETHRRLAAACRDDERIGLNFDDVAPGLSRYVHDAIVANADRAAGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5W6</accession>
    <name>A0A7W7T5W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031249876" evidence="1">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="33226" checksum="854B39C5EF1406A8" modified="2021-06-02" version="1">MGSRRVVFAVIAIVLVVGAAVAYVTTVVRGASPAPVAAAGQVDLMFVELADGRSRVEQVKRAEPDARSGTDLTCQRVYQAAGTRVCLKLAGPGPTYAAEVTRDGAVVKTVPLPGIPSRAKVSASGQIVSWTSFVTGDSYSVPGGFSTRTGYFDLRSGAAVESLEHFAATVEGAPLTAQDVNYWGLTVANDDRTFYATLASGGYTWLVKGDLVEKKVTSLRKDAECPSLSPDGTKVAYKKRIGRLGPWDLAVLDLATGEERRLPGTAGVDDQATWLDADTVAFAAVPRDAKLAAIHTAPVDGSADAKVLIKDATSPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5X2</accession>
    <name>A0A7W7T5X2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPE-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="19441" checksum="CE4CB556D4299297" modified="2021-06-02" version="1">MTENSENPTWGDAPPPQADAPGPRWSGRKTIAAVAIAVGIAAAGGGVIYAASNSDAAQAGLGPRGGGYGRGGPGGMMMGGPGLMFGDTAHGEFQIGEVTEVASDSVTVKSTDGYSKTYKIDGDTKVNGGQGDVDDLAKGDSVTVVATADTADLILESGQFPGQRDGRGDGRGQGNGQQPPDGQRPPGDQGTPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T650</accession>
    <name>A0A7W7T650_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="144"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28133" checksum="D296145B59B324F4" modified="2021-06-02" version="1">MDERTAEHRAGRPVWLVAGALAVTAGLLLGGLYLWAWIGNRTESQHQVYDRAAGRVEVDSGSVDVELVAGRSDRVVVDRELNWSFGRPTVREVWDGSTLRISARCPSSPRLPGCSVRYRVEVPARVAVDARTSSGVLSVVGLTGDLRLTTTSGRITADDVGGALWARVQSGDLVGSGLRTDSIDVAATSGGADLRFAEVPDQVKANVRSGDFVMRVPRGGGPFAVLLSVESGTRIVDVEQNSTASRKIDVESRSGDVRIQYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T694</accession>
    <name>A0A7W7T694_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5091" checksum="B187D3865044F9F5" modified="2021-06-02" version="1">MNTDAITATTTDCDLVIHEFDRPSTLALDFLAFSVHTSGPTAAAPALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A5</accession>
    <name>A0A7W7T6A5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Aliphatic amidase</fullName>
            <ecNumber evidence="3 7">3.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Acylamide amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">amiE</name>
        <name evidence="9" type="ORF">F4559_004689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01242">
        <property type="entry name" value="Aliphatic_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023719">
        <property type="entry name" value="Aliphatic_amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="37790" checksum="D41A101362AEA760" modified="2021-06-02" version="1">MRHGDISSGPDTVGVAVVNYKMPRLHTRAEVVDNARRIADMVVGMKTGLPGMDLVVFPEYSTHGIMYDPEEMYETASSIPGEETDIFARACRDAGTWGVFSITGERHEDHPRKPPYNTLVLIDDAGHIVQKYRKILPWCPIEGWYPGDTTYVTDGPKGLKVSLIVCDDGNYPEIWRDCAMKGAELIVRCQGYMYPAKDQQVLMAKAMAWANNCYVAVANAAGFDGVYSYFGHSAVIGFDGRTLGETGEEEYGIQYAQLSLSAIRDARRYDQSQNHLFKLLHRGYSGVHAAGDGEHGLADCPFDFYRTWVADPTKARENVEAITRDTVGVRECRVGELPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6G4</accession>
    <name>A0A7W7T6G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="10920" checksum="DDB83CCF66179FE4" modified="2021-06-02" version="1">MVDTIEDGDLDDYERFVAEMIADDRPSLFAVLAEYGERTDAEIAAWGLAWPDHVEVVLAGGGRLKSSSTERVATFVRRTRRGCRVRIVRADDLPAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Q5</accession>
    <name>A0A7W7T6Q5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="161"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="376" mass="39781" checksum="974B8D22689E708D" modified="2021-06-02" version="1">MPRRRGPGLRARITVLAAGLVAFVSGLLLILGWLLVTRVVGSMPRYPEGSTVVVDGADVDAGVLADTLARQAQDDVLRSGSIAFLCVVAAAALLAWTLGGRVLRPVQEVTGAARRLSAESLGERLRLSGPRDEVAELADTFDEMLDRLQAAFDSQRRFVANASHELRTPLSVIRTELEVTLADPDADGAELRRMADVVRAATLRAEQLVGALLLLARTEAVGLAVREPVDLTAVVESAWRAVRGEADDRRLRTTFRCGPAPAVGDPALLERIAGNLLENAVRHNLPGGWIEVGTEAGPQWTLLRVTSSGPVVAPERVDELFEPFRRGGTDRTSRTGTGLGLSIVRVAVAAHEGVVQASAVPGGGLSVAVTLPSAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S0</accession>
    <name>A0A7W7T6S0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall-associated NlpC family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030988381" evidence="3">
        <location>
            <begin position="31"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="213"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="34866" checksum="7CE5633371C158FF" modified="2021-06-02" version="1">MSPAQRTVRAALAATAVVAMVGTLPQPIAAADPVPPNASDALKRYNELSTQAEKLNEEHLRAQEDLKVKQGELDRANGDLALANEAIKVLQRDVDMLTEASFEGARFNQLSALLVSDSQQDFLNRTSALGVLAGSNAEAIGKLGEAVAQAEDAQERATTATNDATKLVDDIAKRKTALDEQVGEAREQYRSLSASEKAALNDSGDLGKITVPAGTAGKALEFALAQRGKPYVFGSNGPDSWDCSSLMQAAYRSAGVSIPRTTYGQATIGRSVSRSEVKAGDLIIYYSSQSHVSMAIDGIRAVHASTEGVPVKIQDIDSIGPISVIRRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T717</accession>
    <name>A0A7W7T717_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24057" checksum="F968B3E0C3ECCEAD" modified="2021-06-02" version="1">MLYTVMKRVVAPSARLVWRPRVEGLENVPESGAVILAPNHLSFIDSIVLPMVVPRRVSFLAKAEYFEGRGVKGALSRYFFGGLGHVPVKRGAGRAARASLDTANEILTAGGAFAIYPEGTRSLDGRLHRGRTGVARLALESGAPVVPVGITGTDRVQPVDRRLPRLAPVTIRFGEPLDFSRYAGMAESLPVLRSITDEIVYRILDLSGQEYVDRYQNSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A8</accession>
    <name>A0A7W7T7A8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="408" mass="43097" checksum="2AE9E790DFC9E382" modified="2021-06-02" version="1">MSLWSHRDFRLLWIGDATSHLGATIGRTVLPLLAAGTLAASPFEMGLLTAATTAAFLFIGLPAGVWVDRSRRRPVMLAADGVRFVLLLSVPTAWWLDVLTFGHLVVVALLVGAATVMFDVAYQSYLPTLVGRERLVEGNSKLTVTQSVAEVSGPAIAGGIAQVVGAAVGVLATGIGYLGSALALLRIRTPEPEPAKPAMPNFLAEIGEGLRFVFGNRSLRAIVGCTATANLFSSVFYAVCVLFLVRTLDLSDGTVGLLFSFGGIGGVLGALTAGWWTRRLGQSRTIIAAMLFTQPVVLLFPFAEAGWRLGFAAVSEIVMAYGVVVYNVAQVSYRQAICPDHLLGRMNASVRFVVWGTMPLGGVLGGVLGARLGIVPTLWIGLVGQVLAVLWVLCSPLRTQRADPVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L7</accession>
    <name>A0A7W7T7L7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28899" checksum="BCA253BDB7F2609B" modified="2021-06-02" version="1">MLRTRVAIPVVALYNAWQSVGLGSPHNALVTAVEFDEDRLAEGDVGGLADLARDGWADLERLGLARGRQVHADLARSLRLIAEAGTEYYAFFNAGEDDTRSALVVQSGDDALRVVLRQDKHFVVEPVRPEDAAQSLVSALPEVRPGRGGVISLPEDALSGRQPRRDADEGGGSFLQQSRPTGGHTQETQLVRKLLAEQRTGGGQLYAARRDRQGRKQRCATPLTYFDTVTGRYLSAKTRGGDGTPWITVQPADFTTLQNRLRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K0</accession>
    <name>A0A7W7T8K0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="202"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="431" mass="43633" checksum="0CFFA83F5944080D" modified="2021-06-02" version="1">MAVPKRRGRKHRPGSLTPRQRGLTAAATCAALVPALLSATGGVGWITAAASGGDVEALPPGAGDVLGTLRMRDSGSLGAGGRLPEADELSAALLADADDPSEFGDDFFPGDADFLSGELGIPGVMLRAYMKAADRLAETTPRCNLHWSLLAGIGHIESGHAHGGTVDLKGNTARPILGPVLNGGPGMAAIPDTDGGKFDYDSVWDRAVGPMQFIPSTWAGYAADGNNDGESNPNNIYDATVGAGNYLCAYDGDLGTPEGRARAVFRYNHSNEYVANVLYWADAYAGGVTPLPDLPPGSDEDYGDDDYTPPAPSNPPAPSNPPPPSSSSSSSPTTTTTTTSSSTSSSTSSSTTTTTTTTTTTTTTTPGCPTTTTPTSTSTTTATASSSTTTTTTTVPSTCVTTTTTATTTTTTTAVAGAPTSSSTITPMKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T8</accession>
    <name>A0A7W7T8T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15839" checksum="DCBE5950AF6F45C8" modified="2021-06-02" version="1">MEPDQWLAQYGQKIEEAKRNAVQAENRLGGVGGSATSGDGLVTVVVNASGALTDLILRPALRGEDPERISSSIMTTLAKAQREAAGQVVEIMTEFVGEGDALEFVKSKMPNGYSGDGTDPEEPQPEIQRRDTRPDDDYFTNPPEVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V0</accession>
    <name>A0A7W7T8V0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024244">
        <property type="entry name" value="DUF2537"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10801">
        <property type="entry name" value="DUF2537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="21539" checksum="0433B85DAD439A96" modified="2021-06-02" version="1">MELRVQDGRAVVAGRDGGDERAVDPHNLPLGAGLADALHEWAKVADAVARADSPSADGAGDLLVTRGRQLATRLAADMRTPVEFTDPVSGVLVLVEPEDAPEPVDEPAEAGTPEVGPAEPTPWATGLTVSVFSGAVMAIMVVTLSEGLGETSRWLALLANVLVVGGIAPSVWLARRVPVWRWVAYGVTAGVLVAWFALILTLLDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V1</accession>
    <name>A0A7W7T8V1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6417" checksum="72C193A11CAD20D3" modified="2021-06-02" version="1">MESSRTAVTRLTAECRLVEIDGAQHGFAVHDDPLYLNPRSQAWQAFVIGTVRDWLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X0</accession>
    <name>A0A7W7T8X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="40737" checksum="002C4DF90E7D9D0D" modified="2021-06-02" version="1">MTPIGGEAAGDHRVPAALWDSLPVVLFLLNVLTTHPPGEWPVAVTLTVAAASPLVWRRRAPLVVFALVATAGFAQWVVDVQLPSAFALLVALYTVAANSGPRVTLVAGAVVEVGAVLACLRWTAEGAFLTPFVAVTAMIVAAAVLGVNVRTTKAYLEAVRDRAARRERERERQARVAVAEERTRITREMHDIVTHNLSVMVALTDAAVYAQHRSPEKATTAMLQISETGRQALTDMRRTLGILRVDEPDAERHPLPGIAQLGALADQLGAAGLPTRLDVDGDHAHVPATAQLTVYRVVQEALTNTLKHAPAGTRAEVRIRCSTESVALAVVDDGRGPLSDTPGHGITGMRERAAAYGGTLRAGPLPAGGWGVHTRLFLGSGGTVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9L4</accession>
    <name>A0A7W7T9L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PBSX family phage terminase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="46090" checksum="9431E2173285633B" modified="2021-06-02" version="1">MVDLPLSPRQVESLRESTTRVSIWSGAIRSGKTIASLLRWLIYVASAPRGGQLVVVGRTRDSVARNVFAPLQDPSLFGPIADQVHYTPGAPTARILDRTVYVLGASDAKAEKVLRGLTCCGAYVDELTVIAHDFFVQLLGRMSVPGAQLFATTNPDSPAHWVKRRYLDRLAELSDWRSFAFRLDDNPALTESYKDSIRREYTGLWFRRFVLGEWVAAEGAVFDMWNPADHVVPWEQLPDMARLLAVGIDYGTTNATAALLLGEGVDHRLYLVDEWRHDPAHAQVRLADSQLSAGLRDWLDRPHLPRPSALRPQWVVADPSAASFRVQLHNDGVTTAAADNDVAYGIRTVSSLLAEKHLRVADRCTGFIGEAPGYSWDDSATAKGTDAPIKVADHSLDAGRYAITTTENLWRPTLALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q5</accession>
    <name>A0A7W7T9Q5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32478" checksum="F856B1F1F16441A8" modified="2021-06-02" version="1">MLDNLRRALRADQVRRTLRDKVTRAIDEVVGPYHRAQAAELDRVSRELADVREELRRQSDRIAEDTRRFEVRARRDLVFAGEQEAALESARFVREVMPTVPQFGHPHATLEYALSLVAADGLALEFGVYTGTTLKIIAQALEDRGVFGFDSFEGLPEDWRNGFPAGMFSVDGLPDVPGAELVPGWFDDTLPGFLAEHPEPVAFLHVDCDLYSSTRTVLDLVGPRLVPGSVIVFDEYFNFPGWQQHEHLAWTEYVERSGLEFSYEGYTYDNEQVVMKVTSVLTPATER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V0</accession>
    <name>A0A7W7T9V0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4">3.7.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="PTHR43069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="SSF63433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="FAA_hydrolase_N" evidence="9">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="8">
        <location>
            <begin position="109"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="388" mass="41249" checksum="ACBF0A9B0F043DE0" modified="2021-06-02" version="1">MSWIDDPAFSADAPFGPQTLPYGVIPDGIAVRVGDHALPLRPLADSFGPRLAELVSATSLDPLLAAGSAAWSELRARLVELVTAVSAPRGAALTGIDGTVLPFTVADYVDFYSSLHHAENVGRIFRPDGDPILPNWRHIPIGYHGRAGTVVVSGTPVVRPHGQRRTPDGPVFGPSGRLDIEAEVGFVCGGPVRGRLSTSDAVDHVFGVALVNDWSARDVQAWEYQPLGPFLGKSFATSIAGWITPLEAFSGARVTPTHGDVLPYLAEERPWGLDIRIEVEWNGVVVSRPPFREMFFSFAQQLAHLSANGATVRPGDLIASGTVSGPERDERGSFLELSWNGQEPVAEVGRTFLEDGDTVRLTATAPGVDGSVVGLAEVVGTVVAADER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9X0</accession>
    <name>A0A7W7T9X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031216692" evidence="7">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="16016" checksum="7F23A20350765578" modified="2021-06-02" version="1">MPVRAAVRVTAQLAAVSAVLTAVLASLPLTAAFLLVMAGVATATSAGRTKAGRRGAWVGVAILAGTLPTLVVLVLSGLVPMAGITLVPASDQTRTVGLVTLPGAFVGMPLGGSPVWQAGVLQLVVLLALLVVEGVAIVVVVELVASGLVRRSSPAGELRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y3</accession>
    <name>A0A7W7T9Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13802" checksum="ED5F84E2D2B472B8" modified="2021-06-02" version="1">MDVALGKVIELRESGFQFLHLRDEDGQLDRIMAFKQRRGFIDSILFWSETEARAGRLPAVRDSTRAAQAVWIYEGPLVEAVDRLLDLPEPGARNAPTLMKRTASDLAVVTTLPFKLKLPPGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA00</accession>
    <name>A0A7W7TA00_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="47635" checksum="C07406D58806B099" modified="2021-06-02" version="1">MLTSGQLLAERYRLGRRIAVGGMGEVWEADDTRLDRRVAVKVLKAELSGDPQFLDRFRIEARTTASLNHPGIASVHDYGETASVPDGPEDTAYLVMELVEGEPLAAVIARGRLTADRTLDVLEQAGNALQAAHERGLVHRDVKPGNILVTPTGQVKITDFGIAKAADAAPVTHNGMVMGTAHYIAPEQALGHAAEPASDVYALAVCGYECLAGHRPFLSENAVTVAMMHIRDLAPPLPPDVPPGARALVEATLVKDPRQRYRNGGEFAQAVNAVRSGLPLPAPSGFAMAVGAPHPPSPHPGLPVVNPGPPVAPQHTGTFGRPPVQPGRNRAVLWVMVAVLATVLLVLGIVIVRAIAKSDTGPGGASGTGTTSARATAPADPTPDQVKIDTGRYVGRYADEVMNELAAKNLKPELLDVDGLPVLDRANCRVERIEPVEVSIGEQVRVTCVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT97</accession>
    <name>A0A7W7WT97_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="12"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="47014" checksum="2DB7B99FC4F72206" modified="2021-06-02" version="1">MSTDGRLIAERYRFLDRIGSGAMGIVWRAQDERLGRIVAIKQLLLQPSLDATEQDEAIQRAMREGRIAAKLHHPNAIAVYDVVEENGAPCLVMEYLPSDSLADTLSEHGPLDDLEVARIGAQAAAALAAAHAAGIVHRDVKPGNVLLADSGLVKITDFGISRASDDVTVTKTGLIAGTPAYLAPEIARGQDPSAASDVFSLGSTLYAAHEGEPPFGLSENTLGVLHAVAAGRINPPSQEGPLTDVLLRLLNYDPADRPTMAQARDLLNAVANGRPPTLTGLRPASTPGVLPLGPATATTVLDSDRTHVVRPNNRTHPRTADALPPVVAPPPRKPSNNLPLVIVAVTLGLLLLITILLVALDVFDTKQKDPATPPATNSSSTAVPTTTTAPVTTVPTTERTVETTEEPTTTTRAVTTTTTPPPTTTSQKPTQTTTVPPASVTTTPVQGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTA1</accession>
    <name>A0A7W7WTA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="10543" checksum="2B33861D217828E7" modified="2021-06-02" version="1">MTGFGVDVSGLRQGGTQFGAAGDSLDGVLRTLDSALSAEGQCWGNDESGQAFAKEYVPNSKATLEAFGSLATALAEIRGAVDQTADAYEGSDHGNASGFTRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM7</accession>
    <name>A0A7W7WTM7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031105148" evidence="1">
        <location>
            <begin position="25"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="38159" checksum="7BAA4BEE3E9CDD96" modified="2021-06-02" version="1">MRKIVVAVAAIGLAATTTAGTATAAPDRIDRGVVQRALDNMARTGAQGVLLRVSDNGRSFTMRSGTARVDRPGPVPTNASFRVGSVTKTFVSTVVLQLVGEGRVDLDAPVSRYLPGLLPDGDRITVRQILQHTSGLYDYTRELSGDPAERFRHWDEIEPVEVSTSHPLDFQPGEKWAYSNTNYVVAGLLVTAVTGRWWGDEVERRIARPLGLRTTSAPGDRVDLPGPHAHGYTTWQGKTVDVTRLNPSVAGAAGSMVSTTADLDRFIDALLDGKLLKPAQQAELLKLTEVSSAYGLGIIAFGTSCGTIWGHSGGIDGFATLLYSSRDTKTRLALSANIAPEAGNADGWKEAVDEVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT1</accession>
    <name>A0A7W7WTT1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031314585" evidence="1">
        <location>
            <begin position="28"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="40337" checksum="3097A83A2B7F853C" modified="2021-06-02" version="1">MKRIMRAASTVATTGILLLGAGITAHADTSSHTIEFGTPEQVTSTTESSTSALPEATVDCGIGTTVHNRVTSCSNYRVPVQFFVNEQPYGTATLYTKATAQLDPRNRYEWHQKVELRLVDPSVPEAWLVSATVSLDCNYCSATPGGTKVLIPYTTQTFDITVSSPGRDLVNDSIRPRGTFTAPRFDQGAAYLGDVFRPRCDNTPRVTPRTTGGCVYPDVPPIWQIDVTNPRVDAVGWHVLWAQNNLQHPWGKPRAGWDLHRTFDQTLIGANRGVACGPDVPRPPGRPDLSCDEYPFAQSTEGASRNPDYSCHFLDRNDNSREGSLRKAFLNSLRTLEGDAFQVDVINVPADRQAPPDVTPRGPVGCGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTW6</accession>
    <name>A0A7W7WTW6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="11326" checksum="9B843F0A11C9D655" modified="2021-06-02" version="1">MPRRNRPKRPDDEPRPPAGHGWARAEQAADGEWLVRNVSGAGTTKNYRCPGCDHEIRPGTPHVVAWPSGEHGSVADRRHWHPYCWSSRSRRTPTRRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ3</accession>
    <name>A0A7W7WTZ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="86" mass="8704" checksum="3FD6B5185073C4EB" modified="2021-06-02" version="1">MSVTDEKNTTGTLSAETVDLDSVELAGSVEETTPAEAVTAEAEAVVSNAALLAAAKPKGPRQGGDGDEVEDGPYKPHSPEPATPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU47</accession>
    <name>A0A7W7WU47_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046193">
        <property type="entry name" value="DUF6221"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19730">
        <property type="entry name" value="DUF6221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9658" checksum="1853E9DC2C297B78" modified="2021-06-02" version="1">MHDIARWLRDQISADADVLAMCDAHAAILAVHYVDEKDPASECVGCLTTRWREPWAPNINECPTLRALALAYQHRPGYREEWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU91</accession>
    <name>A0A7W7WU91_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027573">
        <property type="entry name" value="Methyltran_FxLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04364">
        <property type="entry name" value="methyltran_FxLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="408" mass="44624" checksum="6E1AEA626DAB1DE7" modified="2021-06-02" version="1">MDTDTTTSPEARRAEMVAKVRKAGYARRAEVERVLLDTPRHEFVPEADLDAAYNPWQAVITHRFSDGRSLSCASAPFVVAMMLDQLAVNPGDTVLEIGAGTGYNASLLARLTGRADLVTTIDIDPDVTDQAVRNLTAAGHGDVHVVTGDGTAGHADRAPYDRLIVTVSPWDIPDRWWRQLAPEARLVAPLRWRGQSRGVGLRHLDGRLVSDSMHLSGFVYLVTGDEGERGAPITPDGTVNLHWDTDQAVDPDLLHGVLDLPRATSWSDVTIAGDEPHDGIWLRLTVTDPRVCRIDAHPDVAPEVCDPIQRFRAPTLVDGSSLAYLTSRRREEGDDVRWELGAIGHGPAAAELVERLCAEVRDWSVERDARKPTLLIYPAGTPDGDLADGTVIDKTHSRFVLTYDEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA0</accession>
    <name>A0A7W7WUA0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)alamin adenosyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22683" checksum="E7A0E4E40DD4EF3E" modified="2021-06-02" version="1">MPQGVPAVTPEDGLTTRQRRNRPLVVLHTGEMKGKSTAAFGLALRGWNQGWSIGVFQFVKSAKWKVGEEAAFRALGRLHEQTGEGGPVEWHKMGEGWSWSRKAGTAEDHAAAALEGWREIARRIADERHGVYVLDEFTYPLKWGWVDVAEVVDVLRTRPGHQHVVITGRHAPPDLVDAADLVVEMTKVKHPMDAGQKGQKGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC5</accession>
    <name>A0A7W7WUC5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ORF">F4559_001458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="128"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="337"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="486" mass="49811" checksum="C391ED243564A01D" modified="2021-06-02" version="1">MIQLSLAEIAEAVGGTLHDTDGLPVVTGTVEYDTRKLTAGGLFVALPGERVDGHDFVAQAVAAGAVGVLAGRPTGVPTVVAPPVVAANGNAYVLSGDTDGAGAAVLAALGRLARYVVDKLDGLTVVGITGSSGKTSTKDLVAQVLAPLGPTVAPPGSFNNELGHPWTVLRADADTRFLVLELSARGVGHIADLCRVAPPRLGAVLNVGSAHVGEFGSREGIAKAKGELVEALPKTGVAILNADDPLVAVMAERTRARVVLVGEHSSAHVRAVDLDLDDQARAGFRLVTPQGEADVRLAVHGGHHVGNALAAAAVALELGATPEQVATALGTAKRVSAHRMAVTDRADGVTLINDAYNANPESVRAALKSLAAISRATTPPRRSWAVLGPMAELGADSVRAHDEIGRLAVRLDINKLVVVGEDARPMHQGAHLEGSWGEEALVVPDVSAAVELLCAEVRPGDVVLVKASNSYGLWRVAEALLEAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN7</accession>
    <name>A0A7W7WUN7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="35722" checksum="B3F09AA37B568EBF" modified="2021-06-02" version="1">MRAGRLLSLLLLLQARGRMTAGELADELEVSVRTVYRDVEALGAAGIPVYADRGPAGGYRLLDGYRTRLTGFTSAEADSLFLAGLPGPAAELGLGAVVAAARTKLRAALPDGLRERSDRIAERFHLDAPGWFRSGESAPHLETVADAVWNRRRLWLRYRRWGSRPVEVDRVVEPLGLVLKAGTWYLVADAEGDTRTYRVSRVLDARPEKDVFERPEFDLEAFWTDWSERFEERMYPERVTVRFTAKGLARARFLLGSYPARHVPEHPTGEWTEVRVPTESLDHAVFDLLRLGTEVEVLDPPELRRRLADTAAGVAALYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV88</accession>
    <name>A0A7W7WV88_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28263" checksum="9FB3E22840470028" modified="2021-06-02" version="1">MEVTTALRLGSGSLLRIPLLVPLTALVLLLLLIPVGPRQVTDSLYRVDTPGFSVSHRDLVCVAEDADHRRCVVDVAGRELSVRSDLEPLGGTCSARFDGRVLSCMKAGHYGPIRPWVLLDGPTLSDVDTAAARASFPWWQALMDSYGLLVVLGVALLLAVTASVLAFLASGRPHPPHPHQAWYALVNGGVVLGLLLVAGAVFRDAGVADALAGPVAPITAPLVVMPIWQWHAGGGGWTRTEHTAVAFLATLVSSVILLGLIGSLAGFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL5</accession>
    <name>A0A7W7WVL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18156" checksum="7767AADD6D50130A" modified="2021-06-02" version="1">MSEVRWLSEDEQRVWRSFMTAVTRFTEHLDRQLQRDSRMPVAYYEILVALSEAPGRALRMSELAALCHSSRSRLSHAVAKLEKEGWVTRRACPSDRRGSIAELTSEGFAVLEAAAPGHVTAVREHLFDVLSVEQLEALDGISRAISVGLRAECASAKAELGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX0</accession>
    <name>A0A7W7WVX0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16306" checksum="D3C692DF24920163" modified="2021-06-02" version="1">MKIRGAREDGLAAAARWGAALRGKRLPHPSGTTFEGTFTSLLPYRVGSRNRYVAAFPDDPRRRVPVDATGLRDAVLARPFTVSIMIATLTSAWQRVATLRVERPTEEDPDFDVVSHVLPGFALTGAVNRLRGPVYRGSQEGRRGHRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW40</accession>
    <name>A0A7W7WW40_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YkvA (DUF1232 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10506" checksum="6C8F1C0D4CE95E47" modified="2021-06-02" version="1">MSDVLATLGVFAIVVVVLLVAVALFLLFKLVRKHKQVHQPGTPVPTKAAYWVSLAYTVFPIDLLPDPIYLDDIVVLVGGLMYVGSSLRKRREVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW76</accession>
    <name>A0A7W7WW76_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-erythro-3,5-diaminohexanoate dehydrogenase</fullName>
            <ecNumber evidence="1">1.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.11" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047124">
        <property type="term" value="F:L-erythro-3,5-diaminohexanoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="35946" checksum="19EF4DF7142ED90F" modified="2021-06-02" version="1">MSVHGLHRVLEPPGVLPQRADRLDPTPVCGPDEVLVDVGLLNLDAASFRQLREAHGPGIRDAVLDIVAARGKMQNPVTGSGGMLLGTVREVGPDSPLGLRPGDRVATLVSLTLTPLTITGMDWDGTTEQVPCRGTAILFARSIAAVLPDDLPDALALAVLDVCGAPALTDRVVRRHDRPVVLVLGAGGKSGTLSLVAARRAGASRVIGLVPHEAEADRVRRSGLADEVVTADARDPLAVVAALAGGTPAHPTETAPATPSGTGADVTVVCVDVPGCEHGAILATADGGTIVFFSMATSFTAAALGAEGLAADVEMLVGNGYVPGHAAFALDIVRTEPAVRAVFEHRQTPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA1</accession>
    <name>A0A7W7WWA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="14124" checksum="D1C13715C2438247" modified="2021-06-02" version="1">MRLIEDVLALDHVHWETVMSVGDEEFYTTPTGPYPNHKLRISVDPAYGYAAINYVDHEDGTMPVASTISTSSLAPPELHLIFSGQTGAVFPSICAISIVDARHALTEWIETRVRPKCVEWQAYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH8</accession>
    <name>A0A7W7WWH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035197">
        <property type="entry name" value="DUF5313"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17240">
        <property type="entry name" value="DUF5313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="14970" checksum="D5625934F3F0FEC2" modified="2021-06-02" version="1">MSTPAFPLRLWYLVGGRLSARHREWVFHEATKPSWLVWFTVRSFLQVLPLTIVIALVLVLAVGAPLPLALACGSLGLIVGVYFSLSYAAESTDHRLTKYGFPAGAGTEARRRRTLDQEKDRRAAYERAWREPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ2</accession>
    <name>A0A7W7WWQ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10189" checksum="71043A16029DB259" modified="2021-06-02" version="1">MTRNVARRLPVPGESGVGRPARQGPPRHIAAGTLVSTTADRVGQGVTGEGALAGNTSRVDGQARLGGARTGAGVSTVIESGAARSQEDRRRAWERGSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR4</accession>
    <name>A0A7W7WWR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="38128" checksum="E8402B1F3C67DE55" modified="2021-06-02" version="1">MTWLLPRDLHPAAWWVWALGLAVAASRTTNPFLLLTIVAVAGYVVVARRTAAPWALAFRMYLVLGAVIVGMRVLFRLVFGGAEGSTVVLRLPEVPLPAWAAGIRLFGDVSAESLLGGFHDGLRLATMVVCLGAANALANPKRLLKALPPALYEIGTAVVVALSVFPQLAESVVRVRRARRLRGGDGRRFRALRAIVVPVLADALDRSLRLAASMDSRGYGRAALVETGDRVATGLLMITGLLGVCVGVYATLDGSTPRYLAGPVLVSGLVVALVGFRSAGRRVRRTRYRPDRWRAAEVVVAASGVAVAAVLFATSTVDPTNLNPSLVVLSWPTLSWPPLIGVLVGVLPAVLSPAPAFEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX3</accession>
    <name>A0A7W7WWX3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="35989" checksum="1E8981D365C56DBE" modified="2021-06-02" version="1">MSVTPKQLSDELHALCRGQGVQAPGIDKQVGPALREVCGIGKGDAAEIVRTKVTAWVTGLTDQFPTDLRLLVLVPLGLHEDAQNRFLSERIDWLAGRLERGARTVRRRVASGVERLVEAGLNPDRDGSAAPADPWHVAEFDALLRLDGLTPTCTERRTVVADRDGIDEIEWSITLPAASDDGVPGHLDVQVLQGVELVESLRPSSRRWLLRLRLPHRLDSGQRHRFALEVRVPVGQAMRPTYVFWPERRCERFRLVVRFPRHDLPGDVWRVDGALHRDTDDLRPGVNRLAVNDIGEVEVNFPHPREGRGYGVQWRETSGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX12</accession>
    <name>A0A7W7WX12_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S12 methylthiotransferase accessory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YcaO" evidence="2">
        <location>
            <begin position="167"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="583" mass="61415" checksum="4A937DEAD68868DC" modified="2021-06-02" version="1">MTGLPVRVSAGVVRIGPVGCPECFATRRRRMTGRDQADVPDSPLLTESVRVLVAALADHVARDSVLELDLADLSVRRRRFLPDPTCEACGDLPPDRPGPLAITGAHPKRGPDTHRSRSAVETLPRLLSVYVDDETGVVRAVNPGAVGPFVVAGAPVPLRPTGAFEPGFGRSPGYRASEATAVLEALERYGGVTPGGRRTVVRGSFAELAGHALDPRTLGTHPPESHALPDFPYRPFAEDAVCDWVWGHSLVRDEPVLVPERYAYYSTTPGDDRPFVWEMGNGCALGSGFAEAVLHGLFEVVERDAFLLTWYARLPVPRLDLPDGSPAALRSAAITAATGHDVLLFDTTPEYGIPAVWAMAVHPDGEPAVVCAGGAGPTPAHAAVAALDELGPIAVALSARFAGRPGPPTADPGPTGPDTAGPDTAGPSAAGPSAASPDGFADPALATDPDLVRGMADHCALSGLRAVLPRFDFLLDDEREHRPLTSAGPFKAPDLGTDLAEAVRRLAEAGLDVVVVDQTTPEHRAADLVCVKVVVPGAVPMTFGHRNRRVEGLPRLLEIPRALGYADHVLSVDELNPHPHPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX31</accession>
    <name>A0A7W7WX31_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9522" checksum="81BF236EEE534F49" modified="2021-06-02" version="1">MDYLGADDREFVPTSESVSVLEIEPKAFGLRMAELGCRPTRERVPVATESVRYADTWSVTSRHRQSTEARARHIARDGSTPLPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX38</accession>
    <name>A0A7W7WX38_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase PknG</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="59"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="665" mass="72153" checksum="D49B307A33A1D327" modified="2021-06-02" version="1">MKHDPQVAEHRRSCGRCREPVGRARGGRPGLAEGFCHGCGHPYSFRPALAPGTAVASQYEVLGPFAHGGVGWVYLARDTHLDHRYVVLKGLIDASDPGLAAVERRALTTLDHRDIVRISDFVSHPDERTGQSRDYIVMEYVDGLSLGEIGRAGRFGAEPLRVEHVLTCVRHVLEAFEYLHDRGFLYCDMKPDNVIVRPGNRGEHESRVKLIDLGAVRRIGDRSGAIIGTPGYQVDRREIDERGLTVDTDLYTVGRMMEELYRVSEDAARTGDADPLAIGLESFRRLRERAFHSDPDRRFRSARALLDQLDGVHREVASLRDGEPRPERSRLFAPTGVLLDAGLGAVPPLARWTGDGHRGTGDSLPDGRPEPGAVAVGLPVPRVDPDDEAADVVGAVVAAGASDPRRLVAKLATVPDTVEARYARFRAHLAVGGTTPELPDVVGPDRDGWRSSWHRGLLALALGDVKRAASAFDAVYEAVPGEDAPKLALGYCAEHAGADRRAEQLYEAVWRRDPANGSAAFGLVRLRLGRGDRAGAVAVLDGVPTVARHHDAARVAAVSVLCGHLGDTPPAPGDLREAAYRLAALYLDGDESRTRLTAVVREAAFDLGDPDALYPGEVFGARPDVPGLRVLLEQSYRELSRQARSARAHGVLVDLANTIRPRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB5</accession>
    <name>A0A7W7WXB5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="625" mass="66677" checksum="957E3A8E15D4E699" modified="2021-06-02" version="1">MDAIDWAALEHNYGNASDIPDLLRRCADEDADTASEAAEDLFNLLYHQGGWVCSAASAALPFLADLAATAAHHRAGIVGLIDQVAAEAHRVESRFVDDGWQAALDATRHRLLALLDDPDARVRGAATMVAARGIRHPDSVAALRRRWLVETDRVTRWDLAHALGKVHAWHDDDRLRAEVDALIEADDPHLRLAAAHASADPTLAARHVDVLVEAVRHPDAGLWQESAWLGGGPEVVVRATGSLVRDDPAAAAAYVVGLGRSRPVAAVREAWLTLETWHAGIDAIPAFLADHLEHDLPEVRYGAAFAFGCLGVGGHTDRLAALAGDPARRDSRVVSTVGDAAVWALARQGDPRCVTGLTERLTGDRLGFAPAESSHGPGVPTLWLPGIRTVLIPLREHAEHLVDALATRLAAAHDDHVLANSLCRVVQEWGPAAAAALPAVVAVLDDDRIFTQAAKAIGAVGTPVAVDALRRRADEPAAAWALWRTGGEPGPVVDVLTRHEDCALLADLGPLASAAADTVRRLTRSENDWVRVAAAFALWRITDDPTGPAAVLTDIARPLATGDVLPVRIVALKHLADMDIRTEPVAALAQSIADDPRRIAYSGGWQAFTEDETLRTAASRLLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB6</accession>
    <name>A0A7W7WXB6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8567" checksum="8D72952841091BAA" modified="2021-06-02" version="1">MRNLPVPLHDRAAGRRLADPTAVVDLLTHPAATAVAAVAVACVVGLVALMATGVPARHLGTATAAFVTATALCLLLFGFVLPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXT4</accession>
    <name>A0A7W7WXT4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045512">
        <property type="entry name" value="DUF6480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20088">
        <property type="entry name" value="DUF6480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="5928" checksum="5AE44F7BE123BEFC" modified="2021-06-02" version="1">MAPGDTPPDSGQTSGLSHPQPMPSRVPSIVTLVAVTVLTLLVLAFVVAQIIGWSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXU9</accession>
    <name>A0A7W7WXU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-beta hydrolase superfamily lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21683" checksum="EEC1AA30EF3E044F" modified="2021-06-02" version="1">MTALRTFDGLRLVGTLVEPDTPSTRTAVLVHGGGVTREEGGFFGRLATGLAEAGITSLRFDLRGHGESEGRQEECSLTMHLNDISVAVDLGRRETGTVHLIGTSFGGCLVAYYAARRHADVGRLVLLNPQFDYLDRYAGQKSPGTASSPTPRQSATDGHSSTTSSGSARTRSSARSSRRPSSYTAPRTRSSRWSRRGRPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY26</accession>
    <name>A0A7W7WY26_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6224" checksum="F454D34EE19B5DE8" modified="2021-06-02" version="1">MGRPELRIELPADLPSERYEGIADAVSSLLELWGVHEGSASVIAEPVHAADSGRASAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF8</accession>
    <name>A0A7W7WYF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17641" checksum="C3A054413E3C615A" modified="2021-06-02" version="1">MSAAASEINFSDLSNKPADSVRKLQESPSRTLLVHRRGDEEDLVLTTAGRAREVREVVSTTTALFVALMQHSESVRDLVTDVMPTAFPWVRFLPREDMRAFVVELVETLEAADSLGTPAPVTQLIDQWRHTAEVHADPRLLAVLKQDGGDLGDVPAPGAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK6</accession>
    <name>A0A7W7WYK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Streptomycin 6-kinase</fullName>
            <ecNumber evidence="1">2.7.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.72" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050300">
        <property type="term" value="F:aminoglycoside 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006748">
        <property type="entry name" value="NH2Glyco/OHUrea_AB-resist_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04655">
        <property type="entry name" value="APH_6_hur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="31307" checksum="599C62C14E1242E2" modified="2021-06-02" version="1">MITAPADFAVDLGAEARRWRDTLPALATRYCSRWALTPDGDPMFGYVAAVLPVRRADGHPAVLKLTWLDEETRSEPLALATWNGDGAVLLLDHDDADGALLLERLDADHSLADEPIAAALAVIGGLVRRLTVPAPAGLRRVVVDDLAARNRELGTPVEPRVVDHAAGMGRELAASAAHLLVNEDLHYGNVLRASREPWLVIDPKPLSGDPEYGVIPLLWNRLAELDGERGLRDRRAAVVAAAGLDPDRTRAWTYYRAVVNHLWAVEVGDRAFADRLAAITRSTVERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL3</accession>
    <name>A0A7W7WYL3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="8018" checksum="4A9F63FE7044E6F6" modified="2021-06-02" version="1">MARDPDTIQREIEQARDALAATLDELGTRADPQRLVESGKAGLRAKLAEPKIKYTLIVVGAVVGFALVRKLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL9</accession>
    <name>A0A7W7WYL9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12546" checksum="BA20F69FCEB3E6DB" modified="2021-06-02" version="1">MFDDVASYAVRNALTGLASRQRVYANNIANIETPGFTAGRVDFEDTLRRAVASGDTSAKVTPHYSTSTLAARQDGNNVNLDEETMAATKAGLQYKLALRAMDDRYGLVSTVLKGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM8</accession>
    <name>A0A7W7WYM8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="90"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="23996" checksum="DDD5471B19C39258" modified="2021-06-02" version="1">MQRIVYGDHPSQFAELTGPPQNRSAVVVVIHGGFWHERYGLELGRPLALDLVAHGVRALTIEYRRISAGGGWPETGEDVLAALDAVAGPLVTLGHSAGGHLAVWAAARHPRVVGAVSQAGVLDFRGDPQITKRAAELLGGTPEEVPDKYADADPTACLPIDKPMVLVHGENDEDVPISQSEAFATASGAELITLRNTTHMDLITPGTKAWQTCRDAALRLAAEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ57</accession>
    <name>A0A7W7WZ57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="16082" checksum="994D7FB49DE259E8" modified="2021-06-02" version="1">MTRLVRGADGRMWTVRSQIEWRNPSANGDFEHDVSGGHGPGVLMLGVVVVMAVIFVAWTPAEVVVPAWLVIALILVFLFFPVRWGLRRPWVVAAESKKTEELPPERWVGRVRGVLTVRSEVATVARKIEMYSLPDLDGPLQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZN8</accession>
    <name>A0A7W7WZN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29084" checksum="17071F74BC033DE8" modified="2021-06-02" version="1">MTIFGGPAERAPISLSAEEFDVLWERLGLGPMPLVIKVPSPGKTHAERAELERRVWHAVDSRGLGNPRGLEPGLDHLLRLFVRPEREVDGRLWLGKSLRVLAVANGDDGAIATLTESGLTFRAVSGTGLASGVVGMLPQHPAGTGHSVTMPSADLEAAVQGTDGSPRQLEQALRSHGLRQEDAEAVVKMFTGLVHTGNFGAAARDRYNKRCRPDRVVAFFDTEEGRFLQQRRTTGGTPWSTFTPTDTRRLTHQVEQLLGEAVTAAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X020</accession>
    <name>A0A7W7X020_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15888" checksum="8888B656F7CB0920" modified="2021-06-02" version="1">MSFTAHWHVYRPDELPAEETLVVETPADVDHLVARLSDPDSSPAMVFHSARPEIVSEWSGETVDDHLLWALVHKGFGYLDFHSPEHVSCALVGDPASEGYHYDYVDYDPGSGVALDLFTRALKEFLRTAERPTCAEWRDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X022</accession>
    <name>A0A7W7X022_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="3">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dcd</name>
        <name evidence="6" type="ORF">F4559_006795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21851" checksum="71CFE6326C27C56E" modified="2021-06-02" version="1">MLLSDRDLRKEVDGGRLVLEPFDDVMVQPSSIDVRLDRFFRVFNNTRYTHIDPSVRQDDLTSLVEAADDEPFVLHPGEFVLGSTFELVTLPNDLAGRLEGKSSLGRLGLLTHSTAGFIDPGFSGHITLELSNVANLPITLWPGMKIGQLCIFRLSSEAEFPYGSASTGSRYQGQRGPTPSRAYLNFHRTETRRHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXY9</accession>
    <name>A0A7W7SXY9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17406" checksum="CB550F35E2B86E1E" modified="2021-06-02" version="1">MTTWLGLDAWHADAATADDTALALHGSLLFHANVVCVHRVEEHYALSFRFADDPSENIVSTLIERGYGVAAHNGTLQRLAGPVSLNRGALRAAIAHRYRREGRALRFPGQRALHGRYGVSDILAFSAIEEVLPHGIKSVDARGELRPSFVNGKLVLDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY62</accession>
    <name>A0A7W7SY62_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ORF">F4559_000175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19963" checksum="65CAEA135EA35A7A" modified="2021-06-02" version="1">MGLEEKLPNGILLASVEKLVNWTRKSSLWPATFGLACCAIEMMTTGGPRYDLARFGMEVFRASPRQADLMIVAGRVTNKMAPVLRQIYDQMPEPRWVLAMGVCASSGGMFNNYAVVQGVDHVVPVDMYLPGCPPRPEMLIDAILKIHAKIMDEPLGPTRAALLAESGKTTDLIPSSQRFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH4</accession>
    <name>A0A7W7SYH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="30549" checksum="0B13EBCBA89002EE" modified="2021-06-02" version="1">MVELVTPERAHADLRNGRPNNRKISRATVAGYVRAMQHGEWRSDNGVAIKYNQDGLLIDGQHRLSAVCEYGEPVEMLVAYNVPDEAMATIDYGRGRTIADLLTIESKTDHSVVVAAVARRVYAWKSGKFMQLSGFKFTPLDNRRVLGENPEIMDAVQFSRLPDMEQMRATLTTSSRAAFLSWLLRAVDREQAEDFLLKLSTGEGLRKLQPIYALREALLRSERAGRSRAAEWQQVYLVIAGWNHHRRGTECKLIKMPVGLLTNEQMPKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYM5</accession>
    <name>A0A7W7SYM5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="14023" checksum="6272F2B24FF449DF" modified="2021-06-02" version="1">MDETLRDAVLRRLAQLDQAVAHDEAESLVPLARTGINRLADGWRLLLSLHQPDPDGRCDSCQGVLRNRRWPCRVWTTAHRHLIGEGETHRERRRPLRNPFTRIPAQSRTEVDTKPRHSLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ31</accession>
    <name>A0A7W7SZ31_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="24322" checksum="DF1989F310BE0C80" modified="2021-06-02" version="1">MGMPPVVLLHAFPLDSRMWDGVRAELDVITPDLRGSGREPDLDVLARDVVELIEPLGRVILGGCSMGGYVAMAVLRLAPERVAGLVLADTRAGADTDTARATRLAVARRVEAEGLEWLPDAVVPGLLGPEPSADVVAGVRGFVLDQDPVEVAWAQRAMAARRDSAEVLRGADVPALVLVGEHDGLAPPAVGRELAGSLPRSTYVELPGAGHLTPVEAPQAFAAAIRTWWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ64</accession>
    <name>A0A7W7SZ64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative HTH transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c_4" evidence="2">
        <location>
            <begin position="193"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32324" checksum="BDE959C1FA36A5A0" modified="2021-06-02" version="1">MKYKGQAWIRVGPRRGVANAEDERQLNERRRSLDLPFDSRPTPGTTLDDLDLTLFERLVIPSLVPPDVPAANGRTTGQRLAALRLVSPDQIPTAAGVLAIGNDPTAWLPGAYVQFLRVDGTTLADPLNDEKRLSGPLPDTLRQLDELLALNISSTVDFTSGPTEARVPDYPITALQQVVRNAVLHRGYEHTNAPIRITWYADRIEVVNPGGPFGMVSTGNFGSGLTDYRNPTLAEIMRGLGYVQRFGAGIPVTHRSLSENGNPPVEFDSPPSSARRSWARTGPCPRCPTTPTAWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC2</accession>
    <name>A0A7W7SZC2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="25612" checksum="00CD4C1260D9C8A3" modified="2021-06-02" version="1">MADPTEDEITTAMRGLTPLTAAMLADMAAQPDRALILVGQYHPATRAAADRRGLIYPVPAGEHRLTLLGEAVMSRMSIQTGQNKAVADPITDQAVAAAATAIHDLLSPHAHDCAGIYTGQIGSLSPTNEDLARAVLAAALPIIHANASTAAHVHTGECDHRVVPMDVEGATECYHCGPHYGTSRYCHETCPAPDDRPPADIDTLIAEHLVAWPGWAVQRDLLASGTAPSGEDRNTTLRGEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZQ7</accession>
    <name>A0A7W7SZQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">16S rRNA (Guanine966-N2)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.171" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="19794" checksum="52491CBBE9970400" modified="2021-06-02" version="1">MTRIVAGVVGGRRLKVPPRGTRPTSERVREALFNSLTTLVDLDGAHVLDLYAGSGALGFEALSRGAVAATFVESDKQAADVLKANARTLALPGATVLNRTAETAVAVAPAASFDIVFADPPYAVDEVRLGRVLALLVVNGWTAPDAVVVVERAARDPEPTWPAGLEPLRTKRYGDTALHWAERSGVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX3</accession>
    <name>A0A7W7SZX3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14011" checksum="8016CFC3971079C6" modified="2021-06-02" version="1">MNNTALLARIARVAGHPALTATTPDLGRIGNITGTAKRVDIQLGQPSTVEILASWYDLLHQSHIALHDMTRYDPDKTLSVHIDVTGKLDGDEVRVFTALDPVRTARLHALMRGHDSIAIGVGTLCSIEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY3</accession>
    <name>A0A7W7SZY3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="439" mass="46389" checksum="D908F61D9261CF6B" modified="2021-06-02" version="1">MPVDRATRQAWLIWATVVAVYVAALFHRTSLGVASLEAGERFGVGPAALGTFTVLQIGLYAAMQIPTGLLVDRFGPRRMLVTAALLMGTGQVLFALAHSYPLGLAARAVLGVGDAMTWVSVLRVAAAHFPPNRYTVVMSLSAALGGAGNLVATVPLTLLLAHAGWTVTFLITGAGTAVYAAVVAWRVRETPDGVSLPEPERVSPRAVLTRVGEAWRTPSTRLGFWLHFTSMVTPAVLGWLWGFPYLVEGEGLGRAEASAVLSMLVVVAIVAGPVMGAVIARYPASRMTIVAWFVVAGVVCWSVLLLWPGGFVPTPLLYVVFGVLSVGAPISGVAFAIVRDYNPMHRVGTATGVANVGGFGAVTIVALSVGVVLDLVGARTGPGAYRIAFLPAVAVFLFGALRMAVWWRRARAAVFAAESRGETVPVRLRRRRWDVLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T022</accession>
    <name>A0A7W7T022_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein F4559_001476</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10062" checksum="A98AB089E88AD84E" modified="2021-06-02" version="1">MSEPFRFGIRVKPGARRDAVGGRWGERALIVAVAAPAVEGQANEAVRRALARAFGVRRQDVEIVAGERGRDKVVRIDLVPADAGVMLERLLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T070</accession>
    <name>A0A7W7T070_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">V/A-type H+-transporting ATPase subunit G/H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="41351" checksum="C6EB89486A37EE77" modified="2021-06-02" version="1">MAGAEGTGQPAARTHFDVVLRGYNQRQVNERVTRLEYDLKHATRARDAATAQNSELARTLDATRSELEKVKRQLNSLASAPVSTANVTERVRVMMTLAEEEIADIRKAAEDAADATRAQAEAEAAEGRAVHQRAMAEVDDRRKALEIADQQRVADLERSYDERRSELEKSFEEQRAKLTAEHAALVAETKAETARAVADYERRSGELDQRREELEAKYKGYHDDLDKEYEDLREKLRKEHEQHVVDAKAEAAKLRAEVATEVAASRADSEKQIAELESEALARIDQSLSEATTRAEKTVTDADAYADTRITAADRKLADLRTVHTALTEQFTAAQDAVTRAMATLKPLELEAEAEENSEEPTTQLPKPVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T166</accession>
    <name>A0A7W7T166_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12302" checksum="5C85223E58C3370C" modified="2021-06-02" version="1">MHPPLGPGAPAVDRLVAFFRASVDLLDRQLHLVLGAETGRARFRGEIYAFRRRHVEDLLAGAAPAAVVDALLAPLAPEVYEYQRDVRGLTSAEIADGLTWLARRVSDQVTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T168</accession>
    <name>A0A7W7T168_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22074" checksum="2ACC941FCDB2B5DB" modified="2021-06-02" version="1">MSEPEPPSAPRRRGRRTGGEDTKAALLTAAREVFVERGYEHATVRAIASRAGVDAAMVNHWFGGKEGLFAKAVLQVPFDPSAIIARLIDGPADALGERVVRTFLSVWDATDGGQFSALVRSVTSHDGVATALREFFVNTLIGRVLAAIDADHRELRATLIATQIFGMGIVRYVVRFEPFASIDAETLVRAIAPNLQRYLTGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T187</accession>
    <name>A0A7W7T187_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,6-mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="520" mass="55085" checksum="68D21CA505D3394F" modified="2021-06-02" version="1">MTNRDELAEAEPLDAAERRQLDVIRRWGTVGALLLVVGSLGAGAAPVFSPLPGTPVLGLFARMPSATMGVTWTGMFLVVSAWLWLGRFARPGRPRLMTRSQLDRTLLMWITPLVFSLPMFSRDVYSYLAQSQIAANGQDPYELGPATALGVDHPLTTNVPNIWRETPAPYGPLFLAAGRAISMVTGDSVLPGVFLHRLLVLLGLVMIVWALPRLAVRFGVPPVSALWLGAANPLVLFHLVVGVHNEGLAIGLMLVGLEVALRRMPKTTDVPLSLDELGFIVLGATLITMGAAVKIPAALALGFLGVMIARRLGGRFVDLLRSALLLAAVSGVVMTATCLGTGLGFGWIETLNVAGTVKSWMSPPTAMGFLGGGLGLVFKLGNHTDAMITLMRVLTQAVSVVLGAWLLWNAFRGRIKAVNGLGAGLGAVLVLGPVLQPWYVLWAALPLATGVLAKRFRIFATTVSAVIAVILPPTGSAFDGRAYTVPQAVTGALVAFAVCLFVARKQVMPLIRRDPLPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F0</accession>
    <name>A0A7W7T1F0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12270" checksum="9C6452AD05FC7D08" modified="2021-06-02" version="1">MVSTLRVRPYTRTGGRTRSTTALAIEAIVTTNDRADRDALTSTAEHRAIGDLCRLPHSVAEVAARLSLPLGVVRVLLSDMSDLALINVHEGEDSPDGGPSLALMERVLLGLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H1</accession>
    <name>A0A7W7T1H1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="27006" checksum="B9B426FEF4BE7E15" modified="2021-06-02" version="1">MTAPKSLLGRAFALLAVFTAQRPVASLSDLSRGCGLPLSTTHRLVRELVAWRALERRPDGRYAIGLRLWELGVLSPGSRDLRERAVPFLEDLYEVTRHNVQLAIRDDLDTLYVERLSGPNAVSILTRTGDRLPLHATGVGLVLLANAPADVRQRVLDGPLKRFTARTITTAAKLRETLAQVRRDDYAVSDRQIEMTTYSVAAPVRDASGEVVAAVSVVVPAGTRRETVLPAVRTCGLALSRELGNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H7</accession>
    <name>A0A7W7T1H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21701" checksum="3C214369BDECEBCE" modified="2021-06-02" version="1">MRGLHGGSVVSHVWYVAYGSNVLYSRFACYLRGGTPEGTTHVYPGCRDRTPPAADVPLTVPGRLYFATHSPVWGGGRAFLDPDADSTVAARAYLITAGQFADVAAQEMYREPGEEFDLSTVLSVGRHEFGTGRYETLVCLGHRDGHPLLTFTSPWRPADVEHVPPSAAYLGVIARGLVESHGFTDARLADYFAGTAVRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P8</accession>
    <name>A0A7W7T1P8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="42156" checksum="6F3988FD2A825B94" modified="2021-06-02" version="1">MSEQDQPVIEPFGFLAPLPKPVPTPAPTPYAVWDDHPDGTAWVYLGEGNQGLTRPVILSDGFESGPSSLDTLWEGLERGDYPFISRLREQGYDLVLVGYAERSAAIQRNAAVLRSVVFRAVAERLGEARLTVGGFSMGGLIARYTLAKLEHEGFDHQTALYVSWDSPHNGAWVPISLQALAHFLVGVPALSEQINSPASRQLLWRHIETVDGTPAEDPLRSVFLDELKVYGWWPRVPRLIGVANGLPERGNGVPPGDVALAVETGWFAGTELTTQPSGEARVARLKGAFQDREVVVSGLSELDGAPGGTLETFGIAGDKLAATGKVTVRHRTVGFVPTVSAVAAGTLDEPYAPIDPDKSELDDYKVASANEPHTKVTEELGSWIIERLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W3</accession>
    <name>A0A7W7T1W3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26090" checksum="229B02AB5C7FB0C8" modified="2021-06-02" version="1">METLKPGTALFAGPSSAVLRDAAGELFSIALPEEAVAGVRAALTAADAPEPAELAAFAHAGHLGRRTGWPAGRRVVAVLGGDAFAATLAAAGAEPVRAEPDLDSLVDLMPAAVCAWHDGPAPSSWLELDALAAHGIAFQRISREGRHVLFEPVAVPHRDVRARRLAAAGSGHPHLAAYWAGDDVVLGEETPDAAELMLIAALAAKDLAAWAAGRVPATGSLLPKAIPPARRLRVLDLDSGAIADHPVLPVPASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T261</accession>
    <name>A0A7W7T261_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="46221" checksum="20C9F972080D8361" modified="2021-06-02" version="1">MIGSGGMGRRGAGRPPTIDRRALTDRCGPAGYDLVFLLLWKLAPQGGFTMLDAARDWAAREPEAALAHRILVVRAAGGRDISRRRLSWTLRLDNGPPPAGLVRAFLRLWAADRDTEEVDAVADRLDTLCREVAAAHDRATTPDRACPSRVRGESPPTRGHEVRFRALPVFLGTALTRLRGQVPEELPASPGATDDVVLGQVEEEPREGDLRFTRDHLADDTDAPTRGPERRRLVRPPRIAVSLVVLLLIMVGTLSTDSIPNFPIGRQTSSASMPTAPSTTTAGITAWAPSPTYWEKKVIGNAVLRVPFKTQFRSVNVGTRYLYRMAQALVWEFAGAVDIDLSLVPERGNARDDVTVGGMMTLEGACAPARVMALLPGRAEPTSAVLLPAAGSSVRFDLHFPRSTVMAVLRIIPENGCAGEISWLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T287</accession>
    <name>A0A7W7T287_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="26539" checksum="C80CA4C70B21F72A" modified="2021-06-02" version="1">MRFADRVALITGAGTGIGAATAARLAAEGAKVVLTGRRPDPLNEVAAGLGDAALVVPADAADSAAMANVIEKAHERFGRVDLVVANAGGHGLGTATDTSDDDWKLALDANLTSAFVTVRAALPDLVDGGGSVVFVSSLAGLFAGPAVAGYTATKHALIGLTRSIARDYGKHGVRANAVCPGWVRTPMADIQMAHIGETKGLSREEAYTLVTENTPLRRPAEADEIANVIAFLAGPESSAVTGIYLTADSGASAVDLPTIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D2</accession>
    <name>A0A7W7T2D2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="25726" checksum="5578ACF904DB42CE" modified="2021-06-02" version="1">MARQPCYRWRAQPVTVTELERAYRANALFDAHRDDPAFGYRFLAGEARQSGRPMADRTAWRICSSPGWWCAFGRKRSRNGRKAGPPVHDDLVRCDFTATAPNRLWAADITEHRTTERKLYLCAVKDACSNRIVGYSIDSRMKSRLAVTALTNAVARRGDVAGGVIHTDRGSQPVPIKEIRPCARTPRADRLDGQGRSRPRPRPRGMKSGVRSSGTTSTGGVIEHGSHGTANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T327</accession>
    <name>A0A7W7T327_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="40859" checksum="33980A5DA2A5FA54" modified="2021-06-02" version="1">MSDASDKHYLDLLESMTANPGDGVFRRGRGQVFVMDADLARAVLRNDGDRYVDHSDFFYSRTTAVTDRDAQVALGRAGRAFLQDFVDRSRSRLPSLVDRCLRERVPWPDAANLLLLRYFADAFAGEPNLRVLVADIVRRGVRVRGPERHDPVSRAWFRRRVGRALRAALVRASDDELLGVLARAAPGEPPAALAEVYLSFLFATVGATGFLLAWSVYLLGEHPDQRDRPPSWVVRESLRLWPVAWAFGRKPRHPHRLGAERVTVTDEVVACPYLVHRDPRQWPDADEFRPDRWSGQVTGGFIPFGHGPHACTGAGLATGLVEELVGLLHEGRDLVVTSRGVLPRVGASLAPPEFTVTAVRTATPVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3D7</accession>
    <name>A0A7W7T3D7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="611" mass="65334" checksum="BB5D15D9C5AD0A7D" modified="2021-06-02" version="1">MGDLDTALALARAEFHSSTDRWHLVAGPLVRLLRLRYEYLGGPADLDEAVTLGITVDVAGLADVSTAEELSRALVLRGSYYEDAADIGTAVDLARRALRTTVSVDVEDSRVPVLCTAVADALLAAYELSDDQAHLDQALESIEYAASSSDAAVVVGTYGRIVRARSDDLSGIEEAIRLTARAVVITPPGTPQAAVYQADLAEAVLDRADLTDSDADVDQAIGLLRPLVGSLPESSPVRWRCLHLLRAELVARGEDAPAEDRPVRWGERLPAALALAEAAWQPHLALAAWRAVLVLDPAADVAAHAAARLLDLDPDLARFAVELLQRASTPDGPEFSFTDLAPAAHGGPVVLVNIDDLRCDALVVIDGGVVVVPLPGLTAADARAAAHALVEAEDRRERLPDLLRWLWNAIAAPVFDVFRFVGGQEPPRLWWCLAGPYRFLPVHAAGDGENSVMDLVVSSYTRDPAALLVPERPRCAPIALVDTDDHPVPTREVYAPTASPAGIGTATWLHLAAPSVTFDLAALSVPTIDFAYFSAHAAAPVHEGNDLPATFHGGGRLHVVAQRWPAPDVTADLYRELAFDSERTARALHRVLTARRAAHPADWAGYVHYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G7</accession>
    <name>A0A7W7T3G7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20272" checksum="F1A954E1EA130F4D" modified="2021-06-02" version="1">MAACPSGHATAAEDYCDVCGASLAEPDPGESPVPALADCAACGTPREGRFCEECGHDSLAPVPVVRWHARAAPDRAYFRRVLAVGGPDADTLVFPVDDRPCRFDLTGPRVTVGRGGSRSRVPDRELDDPGVSHLHVEFVADGPGWAVVDLGSTNGTTVDDDPRPLLPHTPRPLADGSRVHLGAWTTITVHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J9</accession>
    <name>A0A7W7T3J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyvinyl alcohol dehydrogenase (Cytochrome)</fullName>
            <ecNumber evidence="2">1.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.6" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047059">
        <property type="term" value="F:polyvinyl alcohol dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031071356" evidence="1">
        <location>
            <begin position="27"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="536" mass="56265" checksum="5BFF1255C1A3F0EA" modified="2021-06-02" version="1">MTIRRRVAAAAVCAVSVAALTTTAQAAGTADAARHDGDWGTWSKDLSGSRHNAAEWRITPDNVHRLKLKWVYAHPKSAAPVRSQPAIVDGTAYFGSDDGTFQAVDARTGAQRWSADLRAGLPPGERPPLVWDSPSVSKGRVYFGDLGGRLHALDQRTGERVWTTKVDTHPSATLTSSPIVYDGKVYVGTSSGENANNNGTGDDPAYPCCTFRGHIDAFDAATGALAWRHYTVPQPQAVGTWPSGATRYEPSGAGVWSSPVVDQATGTVYVGTGQNYTGSAGDFDTLLALDHRTGAVKWRNQVTKADTWRAICNTPDAEGYCPGLKDGTALDYDIGATPNLFTVGGRRLVGVGQKLGVYHVFDAATGEVVWRRQLGVPLPGGGISGIQWGSSFDGRRLYIATYFADPGKVFAVDPGTGRVLWETPNPADGCTTGGAAGHPDLCSLAHGAAVTTSPGLVFEGSNDGKFRAYSARDGRVLWTFDTLRDFAGVDGRTGRGGAIAGGGGGAVVANGMVYAQSGYSPEYPSPHGTVLLAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R1</accession>
    <name>A0A7W7T3R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ku protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="2">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22615" checksum="CC5E4DE0B0B78580" modified="2021-06-02" version="1">MDDGRMVVMSDDDFRALPVNTDHAIDVVEFVPAVEVDPIYFQRSYYLEPDKAAARPYVLLRSVLAESGRLAVVKITIRQRESLAVLRARADVLVLHTMLWPDEIRRPEFDFLGSGVEVRPQELRMASSLVESMAGSFAPESFSDDYTVALRRVIEAKAEGAELPVAPVEEPAGEVIDLMTALERSVEQARSARGKSGKKKAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R4</accession>
    <name>A0A7W7T3R4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21278" checksum="938CCA2356B51765" modified="2021-06-02" version="1">MSATRLLVLGVVRGYGRAHGYLIGTDLMAWGAGEWANVKWGSIYHALRQSTKDGCLLDVPVTATRTDYELTVKGEEEYLRLLRDALRRPETRPDLLAAGLALLPSLRREDAIGLLTERSAAWEARREAAAEQVRAWSEPPHVRELYGLWEHSASSGAEWARGLIGRLAAGEYAMRGEPGSPGEPGSWVTLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U6</accession>
    <name>A0A7W7T3U6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="15835" checksum="7CF813B0F8512628" modified="2021-06-02" version="1">MTSRPRAATPSHDRERPHVTTLLHVAAATAALAPPLVFGRLAGSSGGHVLGLGAVLAGAVVAGALVTSLAGAGPATLDWWFLLAFAVVLPVQIPAVRRYLRDAPEAYRSERTASARRARLLLESPTGTPTGSPTRRGRPCAGRCAPRACRTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G6</accession>
    <name>A0A7W7T4G6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="44295" checksum="097BEB8D5F31B343" modified="2021-06-02" version="1">MAWTGTTREYPFREPHRLDLEPEYARLRESEPLCRISLPYGGQAWLATRYEDVRFVLSDPRFSRAAVLDRDVPRTSPRRLTDATLHTMDPPDHNRLRRLVAHAFSPRRVDALTDQAREIAAGLLDDVVRTGPPADLVTGLALPLPIEVICRMLGVPLADREAFTGLIDVAMATTAFPAERIHRAFADLKSYLAELVRQRRTTPTDDLLGALVEARDRDDRLGEDELVVLGTTLLYAGLETTTNQIGNVVYNLLTHPGQWAALRADPTLLDTAVDELLRFTPVVTTAGFTRIAVEDLEIGGVPVRAGDAVMVHLDSANRDDRVFDRPDELDVTRRPNPHVAFGFGPHYCVAARLAKAEIQVALGALVERFPGLRLAADPDSLSWRTGRMVRGLDALPVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I0</accession>
    <name>A0A7W7T4I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31842" checksum="9F0E7CE8616796D2" modified="2021-06-02" version="1">MARPDLNLLVTLDVLLDEGNVTRAGERLSLSPSAMSRALARLRRATGDPLLVRAGRGLVPTPRALELRDRVRELVRGAEEVLSPARPSEPATMTRTFVLRGGDGFVEAFGPGLVAEVGRVAPGVRLRFLRRSTKDFEPLRDDVDLEIAVVEDVPPPDVVGRPLFTDRFVGVVREEHPLACPVTVEGYASARHVHASRRGSVDGLVDFALRPTGHRRAVVTVVDGFTAALALARASDLVATVPERHTAPARAGMRTFPLPFPAPEVTVSLLWHARVDVDPAHRWLRELVADACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J9</accession>
    <name>A0A7W7T4J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031273813" evidence="1">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="19825" checksum="EBC8A6C64B6A8BA3" modified="2021-06-02" version="1">MAALIALSTVVPVGQSVPPVAVDVVVVSGSPGCTPLAVAVGPDGRTVSAAYGRFAAEAGGGASPDAATRKCRVLLRVVPPRGYTYGIARATYAGFVALRPGATALHRASLRVQGSPTPITRESWFTGPVFEEWTADYLPEPSAIVYAPCGGGATFDLSSELKVDPGTADPTVRDVIETDSPYLKYVLATRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R4</accession>
    <name>A0A7W7T4R4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="46583" checksum="75CC8613C36F270E" modified="2021-06-02" version="1">MKPVWTIFISHSTANQPKDATSCRLLELIVEEFTGGGYEVRYDRDFRAGDDWRPQIYEFVNCSHVGILLLDNRARVDSEWVRTEYDYMFGRHLGQSLKLIVVDVESPDPATGKEWWTNLRIPHGIKYDGDESLISSLRTLMPKFPVDMPVGEFLRIRRLSNRLRPVDFPDVRLRHILDELVGSPAGLPLYPIEMLVYRLLRHQLSDVMIKTLFDAEDLFERLGKSAAERVAEQLAASWIEPVPAAEVLSTAIADKSMVVCGPCVDPLTAKRFVRQGTFWASEGEVQIREFDEMPEPPEDVLAVEVDKAFEYYDWDVEVPGQVRRFVIADVGTDPRAGFAVADEVRSRRRGVVVVLWSRPGADPLAEATPAELADCIVGLPEQTARERVVARQIKKLYRALKVEPLPCPPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W3</accession>
    <name>A0A7W7T4W3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8381" checksum="1916545B8FAAB37A" modified="2021-06-02" version="1">MAEKPVTRNIVVQDGTFRGKVVQTGGDLEFVALGDEPGEVVLGASDTVTVTANGRPTVHPAGIITVHASGEVTRQDERPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y9</accession>
    <name>A0A7W7T4Y9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oleandomycin transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="33498" checksum="3D0C70EC59B55D6B" modified="2021-06-02" version="1">MAYAFEAEGLVKRFGDTTALAGVDLAARQGTVLGVLGPNGAGKTTAVRILATLLRPDAGRASVAGFDVVRQPGEVRRSIGLTGQYASVDEDLTGVQNLVLIGRLLDLGTAEAKSRATGLLRQFDLTEAGARPAKTYSGGMRRRLDLAASLVGRPDVIYLDEPTTGLDPAKRDDIWAVVRSLVADGVTVLLTTQYLEEADALADEISVIDRGRVIAHDTPAALKRVVGGQTVLIRPSDPDRLADAAAVLAEVAGGRPESPSRGVVTAPVDGDHVFTEVVRRLDAARIGVTELSLRLPSLDEVFFTLTGRHTETGTEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E7</accession>
    <name>A0A7W7T5E7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="383" mass="40798" checksum="CCF794396297C00E" modified="2021-06-02" version="1">MSAVHPTVGIPDRVPSSARLVLTSAATPCHTPAGVVGNTPVLWIDEPFTTDGRGFWAKLEGHNPGGIKDRAALFLVERARERGDLAPGAPIVESTSGTLGLGLALAGIVHGHPVTLVTDPGLEPMIERMLRAYGAEVDIVTEPDPVGGWQEARRRRVRALLDARPDAWCPDQYHNPDNVAAYAPLAAELVAQLGRVDVLVTSVGTGGHSAGISRVLRHYCPGLRLVGVDTTGSTIFGQPAGTRLMRGLGSSIYPRNVDYAAFDEVHWVAAREAVWTCRELAAHHYAAGGWSVGAVGLVAGWVARTSPPDTRIAAVFPDGPHRYFDTVYNDTYCLANGLLDAEPAANPDAIDHPGERVVDRWTRCTTVTDPVADPRLAHLAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J9</accession>
    <name>A0A7W7T5J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25187" checksum="3A4911742E8951E3" modified="2021-06-02" version="1">MTPLIRLTGITKTLKGQDEPRTILAGVDLAVHSGESVAILGRSGSGKSTLLSLLGLFDRPDDGTYLLGERDITRLPERKAAALRSAEFGFVFQRFFLLKHLTAAQNVAMALVNGQGWLPRRRRKAQVLAALDRVGIAHLAKHRPQRLSGGEQQRVAIARALVREPRVLLADEPTGALDTETGNLVVEVLRSATDHGCGLVLVTHDHDHAARMGRVLTLSDGVLHAVDRAVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5W9</accession>
    <name>A0A7W7T5W9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="335" mass="36372" checksum="915DBC5A45E8AD88" modified="2021-06-02" version="1">MNLRDARVLITGGAGLIGSTIADQLLDEGVSEIVVLDNLVRGRMENLAGPLDAGKVKFVEGDLRDVELVRSVVDGVDLVFHQAAIRITQCAEEPRLAHDVLATGTFNVLEAAVQAKVSKVVAASSASIYGLAELFPTEENHHSYGNRTLYGAAKVYNEGLLRSFHEMYGLDYVALRYFNVYGPRMDVFGVYTEVLVRWMERIDQGIPPLILGDGSATMDFVYITDIARANVLSAKSDATDEVFNVASGTETSLAQLADALLEVMGRTDLRPEHGPERKVNAVPRRLASTANAKAKLGFESTVSLHDGLRELVEWWRVETAKGNPNIAPKSEGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A1</accession>
    <name>A0A7W7T6A1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031038852" evidence="2">
        <location>
            <begin position="32"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="469" mass="49758" checksum="016EA08B6B3B5535" modified="2021-06-02" version="1">MKHSTKLSVRLASVIAIASVFGAITATGATADPEPDPTEIWPSQVTANFTALPCRAGGPTAADSAAAGDLNPVLNNKMRGYMTAYNTSCARAVVQAVKARGLNEYAAAIAISTTIVETGNANLDGGDLDSVGLFQQRASWGSFAERTDPPTATNKFLDVMQAFYPNGSWNTTPIGDVAARVQRPAEQYAYRYAVEAADAVKIAHHLWGVPQGRADIVRINTDGTLTGWHNNDAFTGQWNAPANLGGVGPVDHTRLQLADLDGDGRSDLIRIEPNGTLTAWWNNNAFAGQWNSPVNIGGVGSTDHTRLRFADLDGDGRADLVRVEADGALTAWRNLNAFAGQWSAPTNIGGVGSTDHTRLRFADLDADGRSDLIRIEANGTLTGWWNNNALAGQWNSPVNIGGLGAVDHTRVELADLDADGKADIVRTNTDGTLTGWHNNNAFAGQWNAPANLGGVGPVDHTRLRFADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D6</accession>
    <name>A0A7W7T6D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">4-amino-4-deoxy-L-arabinose transferase-like glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="81"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="602" mass="61806" checksum="373FEA6D20C71A2C" modified="2021-06-02" version="1">MTATLTATSERPAEAAERRGRNLTTPALVVLLLGTAVLYLWNLTDSGWGNSYYAAATQAGAQSWTAWLFGGLDAGGAITVDKPPAALWVSGLFARVFGFSSWSALAPQAIEGVLAVWLLYATVKRTSGAVAGLLAGLALAVTPVAVLMFRFNLPDALLVLLMVAGAYCTVRAIEKASAWWLALAGVAIGFAFLAKMGQAFMVLPAFAVAYLLAAPTSPAKRFLHLLGAGAAVIVSAGWFIVLVELWPKDSRPYIGGSADDSLWELALAYNGLGRIFGGGAGGGMGGGMGNGNVGFGGSTGIDRLFGASMGAEISWLLPAALIGLVAGLWFARGRPRTDRTRASLVLWGLWVIVNGVTFSFMSGITHPYYTVAVAPGVAALVAISGRELWRGRKHLPVRITLAVMVAASGFWGFALLARFGDWLPALRWVEAGLTVLVATAIVMGVRRTAALAVVTSLVSAAAIGVATASTTHSGSIPMSGPAGYSSGMGGFGGPGEGDDSSAELSALLRDTTGTWAAATVSAQGAASLSLASGRAVIGIGGWSGNDPAPTLEEFKRYVADGRIGYFVSGGRGGMGGGGDIASWVADNFTAQTIDGQTVYKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T1</accession>
    <name>A0A7W7T6T1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="330"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="615" mass="66062" checksum="36ABEF61C93965D2" modified="2021-06-02" version="1">MDPWSTRLHELWRVACQAGSTNGFTDELYHGLLSLPGVSCLVGARLTADDRVMLARWADADGIRTSPPGLAEELRAWLATGGPPHRLGVADLPPSAFGRMAGARRFVVALIELADGQRGLLGAGTDADDPAGLHTALRQVSEIVTLADVRISEQRALDDQQARDAILAEASLRMDASLDIADTLRAVVRMAVPALADGAVVHIRRGDRLDQVGVAHVDARRERLLTEHLDRGRWAVDEPGPHDEPRPSGLPADVGLTTMSTTVLRARGREVGLLTFFHRATPPRRTSVAFLRDLAGRAALAIDNATLYEQRRDDVLSLQQHLLPTRLPTVPGLELAAAYNVADHALEVGGDFYGMVTHGDTTTALIGDVCGRGAPAAALTGLARHTLETVLGEGRPAAHAVEILNAKMLDNGISRFLTLATATFTPAGRDLRVETHSAGHPPPLLLRRDGTVTEAACTGRLVGVVPDLNLRPVTDLVEPGDCVVLLTDGLLESRDDQGRFFGDTELLPMLSGLRGLPLPTLVSRLLAGTERYRVVDDAAVLAIRHVGPTLLDTTLPPSEVPAAVLDLVGHHLPEDMALFLDLVDDPVHVTVHGDADWARLELTHHDRTSWAELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T713</accession>
    <name>A0A7W7T713_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="38325" checksum="664A8C47F8685C9F" modified="2021-06-02" version="1">MSVLAHGVGSRHDLPLPLDLVLQGAAVALLASFLALGLLWTKPRFTPLVLPEPAGRWIVRAVVAAGLPFVPGAAWPHVVFVLLWVGFAVLSMLFGPVWRVLNPLRLVVLVARGRRYPERLGHWPAAVTLLAFTWVELVEPHALPWFLVGYAALNLAGGWVFGASWFANADGFEVYSSLLGRLSPVRGNPFRVLAATPPAPGLVAVVAVCLGSTAFDSIGGTPTWARLSPVPDWLGLVLTVLLVAGSYQLATRGFAAALAPTLVPIVAGYVVAHYYSLLVVEGQRAAALLLRIDLTPDETLVAPLVVSSVQIGAVLVGHLLGVVAAHDRTLGLLPKADQVTAQVPLLVLMVVYTAGGLALLFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T715</accession>
    <name>A0A7W7T715_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="30714" checksum="A4F0546D1E6579BF" modified="2021-06-02" version="1">MRVVVAGSSGFIGTSLVAALRGAGHEVVRLVRRPAQAPDERTWDPPAGRLDVDALTGADAIVNLCGAGIADKRWDQARKQVLLDSRTVPTEVLAGAAVEHGVPLLVNSSAVGFYGDTGEEVVDETSPSGTGFLAELVRRWEAATEGPQRVVKLRTGLVLGESGGLFGKLRPLFSAGLGGKLGSGHQYMPWVSLDDVLAATVFAIEHPEISGPVNVTGPSPVTNSEFTRTVGHVLRRPTPWIVPGFALKLVLGEFAEEGVLIGQRAIPRALERAGFRFRHPSLGTAVAAAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T757</accession>
    <name>A0A7W7T757_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025461">
        <property type="entry name" value="ABA4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14108">
        <property type="entry name" value="DUF4281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16769" checksum="231251E45509D4A8" modified="2021-06-02" version="1">MTGFLFQIAFLLTVPFWGLMVFAPKWSGTLKIVSSPLVAVPPLVVFCVVTVGHLPVLWATMSNPDLDTLRAFMNEAWGATAVWAQVIAWDLLIGAWMFRESRRLDLHPLLMGPLLVFTILLSPFGFLIFLGIRHFRDTPDRATQVVTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T798</accession>
    <name>A0A7W7T798_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_005242</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051989">
        <property type="term" value="F:coproporphyrinogen dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="42601" checksum="661E9EA4B16DE4B4" modified="2021-06-02" version="1">MPSALPTGDPAPADGSLPSSALTGLGTRPFGVYVHVPFCATRCGYCDFNTYTAGELGTSASPASWLDAVKRELDLAATVLGTPPRADTVFVGGGTPSLLGADGLAAVLDAVRGAFGLAPGAEVTTESNPESTSPEFFGALRDAGYTRVSLGMQSAVRHVLAVLDRVHTPGRPAAAAREAREAGFEHVNLDLIYGTPGESLDDLRASLDAVRSAGVDHVSAYALIVEEGTALARRVRRGEVPMPDDDVLADKYELVDAALTAQGLRWYEVSNWAATEDARCRHNLLYWQGADWWGAGPGAHSHVGGVRWWNVKHPAKYAELLTAGGSPAAGRETLTPDDRRVERVLLELRLAEGLPLDVLDEDGRARAKAAAVDGLLDEAALAAGRCVLTDRGRLLADAVVHRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E4</accession>
    <name>A0A7W7T7E4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-CoA:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.122</ecNumber>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:23472"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:18195"/>
            <dbReference type="ChEBI" id="CHEBI:18234"/>
            <dbReference type="EC" id="2.3.1.122"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mycobacterial A85 antigen family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="4"/>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030794749" description="Acyl-CoA:diacylglycerol acyltransferase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="31048" checksum="F897D93E34B602B7" modified="2021-06-02" version="1">MISRRTVLTTVGAGGLTAAAVLAAGPMPALDALWSVLGVAGPVPTPKRAVVKVDRVYSRYRGREVDLQTIVPPGVSARGLPMSILLHGLHGSARLAAVANLPEALVTATTRGIVPPFGFVSVDGGDNYWHENVPGDDPMAMLLEEVPVWLAERGFGPVFACTGVSMGGFGALLYGRRERERRESLGAIAAVSPGLITTWEEMAKRKAFADREQWVSLDPLRNLDKVGDAPTGIWIGDRDKFIEGTRRFIEAVKPVVGSITPGRHDDAFYRTITDDVVRFLGKRVPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K5</accession>
    <name>A0A7W7T7K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase-1</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLAc" evidence="2">
        <location>
            <begin position="311"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="553" mass="59172" checksum="B3D669074DF4719E" modified="2021-06-02" version="1">MLVALVPGTENAGAFRTLSDAGVPEGDPVWTSDLAGAVAGLEREHSPRWVWASTARVYPDLLARGVRVGRCHDLEHAEGLLLAFTGRHAQPRGLGAAVARLDGLPVPADQGPPRKEAQPTLFEPEPEPLPGGVSGIDAVVRVHAAQQADRHAERLRLLTAAESASALTAAEMTFHGLPWRADVHVELLERLLGPRPVPGARPEKLAVLADRITAAFGGRAVNPDHPPGVVRAFAREGVEIPSTRAWVLKQVDHPAVEPLLAYKELSRLWVAHGWSWLDAWVSDGRFRPDYVVGGVVSGRWATRGGAALQIPRVLRTAVRADPGWKLVAADAAQLEPRVLAALSGDRRLVEVSGAGDLYTGLAVDAFDGDRDRAKIAMLSAMYGGTSGEAGPLLAVLRRRFPEAVGYVEAAALSGEQGRAVRSRLGRTSPPPSEAWRDAVGNADGTEESARRSRRVSREWGRFTRNFVVQASAADWTAVLLGTLRRRLHDVAPAAHLVFFQHDEVLVHSPEADAEAVCRLVTESAAEATALVFGDTGVVFPIEATAVDGYAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B3</accession>
    <name>A0A7W7T8B3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="182"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="31505" checksum="DF32CD4603374AC2" modified="2021-06-02" version="1">MTTADPDLAAAFDEHRSHLVGVAYRLTGSVADAEDAVQEAWLRLANRTGEPLVEPRAWLTTVVGRICLDRLRSAAVRRESYVGSWLPEPVVTTLDPRADPAEAAVLDEGVRLAALVVLDRLGPEQRVAFVLHDAFGVPFDEIAAVLGCAVATARQHASRGRRAAADAAPPSRVALTEQRELIERFVAALGSGDVDAVVALLHPDAVVVGDGGGRARTALHPVVGADKVARFLLGLIRKYGGLSDAVPVLVNGDLGFRFAEREDLAARVGTFTFRDGKVSGLFDISNPDKLRHVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M3</accession>
    <name>A0A7W7T8M3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030517841" description="DUF4129 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="139"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="22568" checksum="CC3BA90654DEC395" modified="2021-06-02" version="1">MKSRLLVAGTALLLVAIAARGTSPVRYAQPPPVDDTAVEVPPSLEVEAVPDYGAGPVGASLVLVYGVLSLAAVVAFVALLWTLFGRRKRRPRGRDVVPVTDADAVDGPPSEVFVDGARAALHELRAREGGPPGDAVVAAWLRLERAAADSGVTRLDHQTSTEFTGSLLDRYRVDESATAALRGAYQRARFGTGEVTEADARTATTALATIVRDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N4</accession>
    <name>A0A7W7T8N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin 2</fullName>
            <ecNumber evidence="2">1.8.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase (NAD(P)) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16655" checksum="CB8B566E959F05C7" modified="2021-06-02" version="1">MSTDTAGTVVCEHCGHKNRVQAAASGKPTCGHCHQPLPWIVDAGDNDFAELAERATMPVPVDLRATWWGPCRQVGPAPAQPARERAGKVKLVRVDVDRAPVLSQRFDVKAVPTLMVLRGGEVVARQAGAAPVPVLREWLDQAPARPTSTRVGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T949</accession>
    <name>A0A7W7T949_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030977032" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="536" mass="55678" checksum="9327A38DBB194101" modified="2021-06-02" version="1">MHPFRRRGAVALAVAALTASAVQFLAPAGVAAPAPAPCGPLDVTFVLDDTGSMGGAITNLKTGINSIVNDVVTASGGDYQFGLVTFKDNITVVNDLAPGNAAAVTNYVTNTLAAGGGSNEPEASDEALNTAVNRKPAAGRPQNVDFNGVWRTNATKFVVLVTDARPGGFDDAYGAADVANASAVANSALANGIKVSAVYVPTSATYQAQIVPVMQNYANTTGGLYTAAAADGSGTASAIRKFLTDCRQTDVWLHDQTTDTGVETNPNGVVWNSPDIKVCPTAADCPGIQPVVGATNYVHVRLNNPGPYGSGTGLGTLKVYYVDAGGSTSWNNATNGDWTFIGQQSVSVPAGVTVVKIPWVNVPGPGHFCLLARWVSATDPMTFAEGSNTALNTKNNNNIAWRNFITVRVKPTKPVKSWFTVGNATGRTIKTDLVVGTPGKPLVGNGRVVIDLGPRLFERWKAAGGQGEGVKQAGETSIEIADPRRAVLHGILVEPGERFKTELTFTGGTVGEFEQTVTQLSEGEDIGGVGYQVIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T976</accession>
    <name>A0A7W7T976_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhzF family phenazine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PTHR13774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="27798" checksum="420419F57223AB41" modified="2021-06-02" version="1">MVEVLRYTAFSADPAGGNPAGVVLDATGLSDAEMLEIAASVGYSETAFVVPRADGFGIRYFSPVVEVPFCGHATVATAVASGIAGRLVFHTPAGVVEVETADGAATLTSVPTSSTPAPAADVAAALAALGWTADDLDVRYPVHWAFGGSTHLVVVVRGRSRLAALDYDFDALGDLLRAHGAVTADLLWQAEEDVFHARNPFPVGGVVEDPATGSAAAAFGGYLRALGVVAAPRVITVHQGVDMGRPSELVVDVRPDDARVRVTGRAVPIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T993</accession>
    <name>A0A7W7T993_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="93"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="24538" checksum="D05000540448D9F6" modified="2021-06-02" version="1">MDPLAPLLELPGVADAVTAARDAVFAVHRHRVNLRGWATTAAEASVRAARSSAALDGGSTDIPESGEVADPVLAGALRVAEALGTVFPTWRRAPLQALARLHVLASADLDDTPGRPRAVPGLSERLDLLAGLVTGGTSVPGPLLIAVVHGELLSLSPFTVANGVVARAAARLTAMSTGVDPKSLGVPEVHLLRNRADYDAALIGFSTGTPEGLTGWILFQCAALESGAREARSIADAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q8</accession>
    <name>A0A7W7T9Q8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27844" checksum="E2E6879E48FFF390" modified="2021-06-02" version="1">MEKPRLIASDLDGTLLAVDGSVTGRTAAAVRRTRAAGLPFVLVTGRPLRWVREVCLAAGASPLVVCSNGTVLYDVLADGVVWRHELTPAMLADITSALDGLLPGSTFAAERVGRGVDPYLSEPEYPHTWSHDDHTTASRGEVLGHPAVKLLIRNPEMTSDLMAEAVTSLLGDSVVATYSTNSGLVEISPQGVTKATGLAEVAEREGVDAADVVAFGDMPNDVPMLHWAGHGVAVANAHPEVLAVADEVTDAHSADGVAQVVERWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U8</accession>
    <name>A0A7W7T9U8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding LytR/AlgR family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="171"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31069" checksum="8CEC5FFB8A36C137" modified="2021-06-02" version="1">MGKMRGTVTTQENTGLLVLAVDDEAPGLSEIKYLLESSPHIRRVLTAFDAAEALRVLRGDYEQEVMERTKAGLPPVDAVFADINMPGLSGTDLARVLGAFRAPPALVFVTGVEHSEAVTAFDVGALDFVTKPINEDRVNKAIARVVERVATKPVSTPEPVPAQEAQDDEVIPVELGGTIKLVPRASVRYVEAQGDYARLHTADGSSHLVRIPLAQLEERWENAGFVRIHRSFLVALPLVTELRMTSNGYAVVIGAGEDAKELPVSRRHTRELKERIVRPPKSGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y2</accession>
    <name>A0A7W7T9Y2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="48030" checksum="003B351406C77D15" modified="2021-06-02" version="1">MVDPAQHFLPLSGPEEIGTSIELFTGGGGLALAMHRAGFRHLAAVEIDKRACATLRENRAVEYDPAHEQAAGIHSEWPLIEGDIKQVSFDHWRDKVDIVAGGVPCQPWSLGGAHKGYDDPRNLWPELFRVVRETRPLAVVAENVKGLLRPSFKPYYEYIINELKAPFEERLSGDSGVDSREDWEHHNKRLVKALTEDTIPADQRYDVKYKLVNAADYGVPQIRWRVFVVAFRRDLGLADWEFPEPTHSEAALLRAKADGSYWDEHKVAKDKREKPDVDLDPGDDRTKRWRTLRDAIQGDGTAALPRLKPPKGFKVENEPHIHHVGWPGAREYPGHTANELDRPAKTIKAGVHGVPGGESVMRTTDGSIRYMTVREAARVMTFPDDWRLAGPRGEQMRQLGNAVPVLLGEAIARSVAEALRPHLGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA19</accession>
    <name>A0A7W7TA19_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15071" checksum="5A6482B3591D2CEB" modified="2021-06-02" version="1">MTADQVEDATARLYLAIGRLSRLLRRTGSPGLGPGAVSALATLARCGPMRLGDLATKEGVAPPTLSRIVAALVEAGYVTREPDPQDGRAWLATPTPEGETMVSGVRSARVHELQRRIEQLSPAHQSALVDALPALEDLVGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA29</accession>
    <name>A0A7W7TA29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="49"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="41422" checksum="A87490D48446F5FA" modified="2021-06-02" version="1">MDTVVAAPRALLGRTITGPAWVRVRAGRIVEVVTGEPPVGAEVLADGLLTPGLVDIQINGAVGVDFAEVDPVSMAVVTRALPQTGVTRFLPTLITAPVGVVLRQAHDVLAASAALPENSGARPLGVHLEGPFLSPKRPGVHDPALMVEPGEAEIDALLDDEVLAGALRMVTLAPEQPGGFEAVRRLADAGVLVAVGHSDATGEQTRTAAEAGARMVTHLFNAQRPLGHREPGVPGVALVDERFTLGLIADLAHVGPDVCRLVFNAAGPRVALVTDAVAAAGMPPGRYQLGGADVVLTEDGVPRSPEGTIAGSALTLDRAIRNIVSVGVDAADALASATIVPADAIGEPTLGRLTPGAVADLVWWDEDLRPRKVWVDGVVVYDADAAVVPAGREPALEVVATAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA32</accession>
    <name>A0A7W7TA32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="686"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="713" mass="75945" checksum="5673CF3B6CD754FC" modified="2021-06-02" version="1">MTDVENAVRAAFATGTPLPLDAPVSGDLLADLLTSTPRGRSALRLQGARITGPFALAGARVRHVVDLEDCTFDEAPDLRMARMTGLRLRGCRVPGLLGRNLRVGSDLALDLGFTSDGVVDLTDSTVDGTFHLAGAVLRGDGEHALLAARIRLSGSMQAVALRADGEVRLRGANVGGSVHLGGASLVNADQDVLDASGVTISGNLFCDAEGGRFTAEGRILLDGSRIGGDVVFSGARLRAGVVDRPVLVIPRGTADESASLVCDRLRVDGNVELDDGFTSSGTVRLSNAEIGGYLRLSGAVIGRRQPVEDGDAQERIPVALHADGIRVQGDLEARGAVNGGFVGDGVRKTALRVYGQVRLVDAEVRGSASLSGVKLHAPGFDVLFADRLTVGGTLFLRDLRAEGSLRLQNAHIGSTLDLSGAKLRNPRRRPDGTVKPSIDARVATVGKDLLCSQGFEAAGGVRVRLAEIGTMATFAHARLGGPGSEVGLNAHGLKTRVLRLPEEHVPEGRVILTRAEVSAVTDSEALWQATGGVEVEDFTFDSITANPAVDVRTRLAWLRKVQPDFVPGPYEQLAAMYRDGGEEELAQQVQLEKQHRRYSELGRAGQVWGLLQRWTVGYGYRPWLAIAWLGAFWLAGALWFLGHEMVRLNDDESPVWNPWLLSMDLLLPIVDLGQDGKWRFVGASQWISGTLVAVGWILASTAAAGATRVLKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA37</accession>
    <name>A0A7W7TA37_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="258"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="50800" checksum="B01AC7CBA36C9972" modified="2021-06-02" version="1">MSPGTVSGWTRLDRTRLGTRLALGLGVLALAVFAVLGAVMAGSMEDYLAGKLDEQMRGTQIDLEKDIAKYGDLHRSAYGWYSAVYDVRDGVAVPRSTGDLPADHAELSSIALLTGTEPVFRTADLAGDGTYRVRGCPVGAGVVLVSAAPMDEITTTVRRLVLVEIGAFAVALAAFVVIGRAVLRRGLKPLSDMAAIARDITSHDLTDSARLPVRVETGAGGVEVEELRTAFNTMLEHIDSSLAARTAAEQRLRRFIADASHELRTPLTSIRGYADLFRYAAANAPGEREAHLDKLRSEARRMAVLLDDLLLLARLDAAEVETPLRTHRADLVEVVREAADAFVVARPYHPLAVTVPREPVVLEFDPVRVRQVVDNLLANAASHTPAGTAVSLALAVSGRYAVLRVADAGPGIPEGEQARVFDRFHRVDDSRTRGRGGSGLGLAVVHSLVAAHGGTITLRSRPGRTTFTIRLPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC1</accession>
    <name>A0A7W7TAC1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16267" checksum="786708A9CE94AAC8" modified="2021-06-02" version="1">MVERALAEVRRQREAMAARIGLPVWFRLVLWVAWGGLLAAPVVATERERLGVAAFPYVPVAVVVSMVVLVMYRRRSGMWTAVRGRDYPGLRALVPSTALVFGGSACVVWGLALAGLPYLALSCVPLLAGLSVVQAWRVNAAVRLDVLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAL5</accession>
    <name>A0A7W7TAL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7220" checksum="505A0A34CF75BEA1" modified="2021-06-02" version="1">MNAETRRALVEVAEVVERAHTHHRRRDEHDIDLGHTPRVTYSPLTLALAEALDALRGVLDDAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TC16</accession>
    <name>A0A7W7TC16_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="189"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="44072" checksum="8139AC29C045EA28" modified="2021-06-02" version="1">MGTTGMSAAVWGMSAERWRGTIKSKALSGKTEERYLATAHRWVGGLTIRGSTSSRTRSRFTTSRTSSRTSSSRPHPRTPPTTTVAQERHAAHDPRHSGDAQPLKSLRLLAAVVERTGWCMWKKGGGVTGGWKRLDYLLSWIDISNTRSLPILARRAYIPDELLTADVLDSWPLTVPCVAQLAESGIGFERPITFLVGENGSGKSTLVEAFAEAWGLDARGGRAGRKYVNDRPKTVLGELLRWETTGAGARHKSGTRTKRRGYFLRAETAFGFMDAVSGMNGYWEEDTSEMSHGEGFLTVLSTMFREPGFYLMDEPEAALSFKSCLRLVNLMHDLGESGAQIICSTHSPILAATPGADIIEVGDHGFRRTEWKDLELVDHWRRYLNNPDAYLRYITNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT92</accession>
    <name>A0A7W7WT92_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035165">
        <property type="entry name" value="DUF5319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17252">
        <property type="entry name" value="DUF5319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14333" checksum="3BA535D9ADF8793E" modified="2021-06-02" version="1">MPHDALPPDPFAGDPEDPARTLGEPVDDHDHPPMDDTERAELIGDLSDLAVYQALLEHRGVRGIVVDCGECDEPHYHDWALLRSSLEQLLSDGRMRPHEPAFDPDPAAYVSWEYCRGYADGVTASENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTC3</accession>
    <name>A0A7W7WTC3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair exonuclease SbcCD ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="42406" checksum="91A78E487011E632" modified="2021-06-02" version="1">MSFDRMRNMLTRAAEIRESEQQQIFDALDEIHARMSPLETLGSVRKRLSELPDRTEVGVLAERLDEALSRLESQDQAVQEIGRAVEGLVDKLAKPFAQLDGRLDGVAGRFEGVAGRMDGLEDKLSHIHKRLDDLDLHLDKQDGKTDAVPSLVTAPLRERIEALEAALRGRLDEVDEGVHEHLDGTREALARSVADASTSLSETVVAARDAVSGAVSSAQDSLTSAVRDSRDSVHGRLDETRESLRAALDETRDQVDATDRLEALAQRLEQVTSRLDTMTSRLDSVEDDFASRIAELSGVVSSGISAVEGTLSARPDSDSLAAMVRKSNQESELRIGGQLDEAMATFAELILGGGPATPPPPPTALPRPQRRTRKGPKDARVDDDDLTAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV1</accession>
    <name>A0A7W7WTV1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="15" type="ORF">F4559_000227</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="91"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="168"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="422"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="500"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="627"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1045"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4962868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1160" mass="128232" checksum="5C5F2ADC2D5DC7F9" modified="2021-06-02" version="1">MAISRATKATAATNSTSGIPGAPKRVSFAKIHEPLQTPNLLDLQIQSFEWLTGDEAWFQRRVDAGDEAPTGGLEEVLNEISPIEDFSGSMSLSFSDPRFDEVKASTEECKDKDMTYAAPLFVTAEFTNHTTGEIKSQTVFMGDFPMMTDKGTFIINGTERVVVSQLVRSPGVYFDTAIDKTTDKDVFSVKIIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWSTEQIRERFSFSETLLTTLEKDHTAGTDEALLDIYRKLRPGEPPTKESAQALLENLFFKDKRYDLAKVGRYKVNKKLGLAAPIATGVLTEDDIVTTIEYLVRLHAGETSMQPGETEVPVEVDDIDHFGNRRLRTVGELIQNQIRVGLSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQINPLAGLTHKRRLSALGPGGLSRERAGMEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSSFARVNPFGFIETPYRKVVDGRVTDQIDYLTADEEDRYVKAQANAKIDDEGNFVEDRVLVRKKGGEVEFIDPADVDYMDVSPRQMVSAATALIPFLEHDDANRALMGANMQRQAVPLLRSESPLVGTGMESRVAVDAGDVIVAKKPGVVEEVSADYITVMADDASRQTYALHKFRRSNQGSCINQKPIVNEGDRVEHGQVIADGPCTENGEMALGKNMLVAIMPWEGHNYEDAIILSQRIVQDDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSEEVLADLDERGIIRIGAEVQPGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGEYGKVIGIRVFSREDDDELPPGVNELVRVYVAQKRKIQDGDKLAGRHGNKGVIGKILPVEDMPFLEDGTPVDIVLNTHGVPRRMNIGQVLETHLGWIAKQGWSLEGDESWAQNLPEDLLHVEPGTKTATPVFDGAREDELMGLLGSTLPNRDGERMVKQNGKATLLDGRSGEPFPFPVSVGYMYILKLGHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDVLGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIEMRDGDDEDLERAAANLGINLSRSESPSVDDVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV9</accession>
    <name>A0A7W7WTV9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">F4559_000242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003938093.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7W7WTV9"/>
    <dbReference type="GeneID" id="64139840"/>
    <dbReference type="GeneID" id="66836921"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="11502" checksum="76FF1D6D8DDFBC46" modified="2021-06-02" version="1">MAGQKIRIRLKAYDHEAIDASARKIVETVTRTGARVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDILDPTPKTVDALMRIDLPASVDVNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU80</accession>
    <name>A0A7W7WU80_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Hydrogenobyrinic acid a,c-diamide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="6" type="ORF">F4559_001369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + 2 H2O + hydrogenobyrinate + 2 L-glutamine = 2 ADP + 2 H(+) + hydrogenobyrinate a,c-diamide + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:12544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:77873"/>
            <dbReference type="ChEBI" id="CHEBI:77874"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 9/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and hydrogenobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of hydrogenobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CobB catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.9" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043802">
        <property type="term" value="F:hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="251"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="453" mass="47159" checksum="4577D44D143742E8" modified="2021-06-02" version="1">MNRLVVAAPASGSGKTTVATGLMAALRRAGDRVAPFKVGPDYIDPGYHGLATGRPGRNLDPVLVGEHRVPGLFAHGSRGCDIAVVEGVMGLFDGRVDTEGIGSTAHVAKLLGAPVLFVVDARGQSRSLAALLHGFRGYDPTVRFGGVVLNQVGSDRHEQVLRTACADVGLDVLGVLPRDDKFRLPSRHLGLVTAAEHGGEAVAAVDAIAEAVARHVDLGAVRRLAARAPASVVAAWRPEHEVDHVPGRPLIAVAGGAAFTFGYAEHAELLTAAGAEVVVLDPLRDKELPDGTAGLVLPGGFPEQHAVRLSANVTLRTAVARFAAAGGPVHAECGGLLYLANSLDGLPMCGVVDAEGAMTPRLTLGYRDAVAPTDSVLAQAGTRITGHEFHRTALTTPHGTEPAWRWHGPDRRPVAEGFVVGAVHASYLHTHPAGAPESVTRFVRACATTPAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU98</accession>
    <name>A0A7W7WU98_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rlmN</name>
        <name evidence="14" type="ORF">F4559_001320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="113"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4963961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="39797" checksum="0FC51286388DF9F6" modified="2021-06-02" version="1">MTALPLVFDAPKRGLPPRHLADLTADQRREAVAALGEKPFRAAQLSNHYFGRLAVDPDEMTDIPAASRSRLVADLMPTLWTELRSVEADGGTTRKTLLRAHDGTLVESVLMRYPDRATLCISSQAGCGMACPFCATGQAGLTRNLSTAEIVDQVRRGAAAMRDGELPGGPGRLSNIVFMGMGEPLANYKRVVEAVHRICDPAPAGLGISQRSVTVSTVGLVPAIRKLTDEGLQVRLAVSLHTPDDELRDTLVPVNTRWKVAEVLEAARGYADKTGRRVSIEYALIRDINDQGWRADLLGKVLRKHLGQLVHVNVIPLNPTPGSKWDASPKPVEREFVRRVEAQGVACTVRDTRGQEIAAACGQLAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA7</accession>
    <name>A0A7W7WUA7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA polymerase IV</fullName>
            <shortName evidence="13">Pol IV</shortName>
            <ecNumber evidence="13">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dinB</name>
        <name evidence="16" type="ORF">F4559_001444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 13" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="15">
        <location>
            <begin position="30"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="13">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4964085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="46153" checksum="EC110CA98B660DDB" modified="2021-06-02" version="1">MGRSANLPRGLVDRFRVRGDDKPDDGGCPMLHVDMDAFYASVEIRDDPSLAAKPVIVGGTANRGVVASANYLAREYGVRSAMPTAHARRLAPHAVFVSPNFARYQEVSRGVMSIFRDVTPLVEPLSLDEAFLDVGGALRRLRTTSAGVAALVRARVEETYGITCSVGVAPTKFLAKLASGMCKPDGLMVVPRSEVSEFLHPLPVSALWGVGARTAEQLAQVGLDTVADVAAASLPRLRRLLGISLAEHLHALAQGHDDRPVVPTVREKSIGAEETFEVDHYDRELLKLELLRLAERSTTTLRSRGLRGRTVSIKVRFADFTTITRSRTLPTPTDVTQEVYRTAVVLLHDHVPPGAIRLVGVRIEQLVERGEGEQLLLGTPEHGWRQADQAADLARTKFGTTAVRPASLLTPPPARSADPLPPRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG6</accession>
    <name>A0A7W7WUG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="22266" checksum="E20EC28AF9CC49E5" modified="2021-06-02" version="1">MTTDDDRTLWSRATEGDGYAFGELFDRHARAVYNHCFRLTASWAEAEDQLQATFLVAWRKRDRVVLERDSALPWLLAVATNVVRSHQRTLLRRLRLVRRVPAENPVPDHADHVAERVDDQRRMGELLKAVERLPRNQREALALCVWSDVSYADAAAVLGIAESSVRARVSKARARLGREYHEVVVPNRTVEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH6</accession>
    <name>A0A7W7WUH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="40613" checksum="F82F8AF3218456D4" modified="2021-06-02" version="1">MSTPVRADRRVMGLWAAVMIAALVVVLVRAGDGLIDLRVYRVGGRAWLEGVRLYAEGFPKPLDGPALPFTYPPIAAALFSLLALAAWPVAVFLWTALGLALLTAVSLATARHLYGRTARAVFVGLAVTAGSLVLEPVRQTLDFGQINLLLLGLVALDCLLPTTKWPRGLLIGVAAAIKLTPAVFVLFFLARKQVKPAVTAVVTFVACGLLGYAVAPTDTRDYWFDALLDPGRVGGLAYAGNQSLRGFVHRLGLTGFAETATWGVLCLAVLALVVLAVRRSGDDRVAGLLAVAIGGLLVSPVSWSHHWVWVVPALVYLVHRSWKWAVAVAVLFLLGPHWFLPREGDVELHWSWWQHVVGNAYVLAGVVALVPLVRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK9</accession>
    <name>A0A7W7WUK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="2">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="423" mass="46568" checksum="C55D183CC4751BD2" modified="2021-06-02" version="1">MAVTTTGVAGALAGVVERLLGTRLPIGLRAWDGSTAGPQDGPVAVIRSRRALRRLLWNPDELGLSRAYVSGELDVEGDLTEGLKRFWELARGGALRKPRAADVVGALGTALRLRAIGPRPAPPGEEARLSGRLHTRRRDAAAISHHYDLSNEFYRLVLDPSMAYSCGYFVSPESTVEQAQHAKLDLVCHKLGLAPGMRLLDVGCGWGSMIIHAARHFGVHATGVTISARQREHILGRIAEEGLTDLVTVRLMDYREIADGPYDAISTIEMGEHVGEENYPEYAATLYRSLRPGGRLLLQQMSRGTTAPGGGAFIESYVAPDMHMRPVSRTLTHLEGAGFEIRDVEALREHYVWTVRAWARTLEQRWDEVVRLVGEGQARVWRLYLAGGALTFEEGRMGVDQVLAVRTGDRGESGMPRVREWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV45</accession>
    <name>A0A7W7WV45_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031295024" evidence="1">
        <location>
            <begin position="26"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="89"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="518" mass="56532" checksum="AC47376EF194C44C" modified="2021-06-02" version="1">MALSTPIALILALTLSGLATPQAEARTQDPIKWSTCAEDVLKAVPAALRDKVTCAQHKVPLDHQDPQRGTISLSLLKRPAADQSRRIGSLFLNPGGPGGSGLVYPAYGESLFRPEVLRRFDLIGFDPRGVARSTPLKCFRTKEDADAVFNRLSVVPITDREVREAIDATEDYTDSCGKVAGPLLDHMSTEDVARDLDLLRQAVGDRQLTYVGFSYGTLLGATYANLFPSRSRALILDGNVDPTLRTRDGAEYDRQRAQGFELALDAFLKRCAQEGPKCAFSANDPRAKFDAARDALRTRSVTLPSQEVVTYTSYVGTVTGALYSPNRFKDLATWLQAVHAALDPGVASVPAAVPDLGPNRGRYDVRVGVGDAEYLSDDSYYGVNCTDKPFSTGTRQFPRIAKQWERESPTFGRQQAASDLLTCPSWPLDEPDRYSGPWNRRTPHPVLVVGNYYDPATQYRFSRRMAAQLGNARLVGVDAFGHCILGDSAGVDAVAADYLVDLKVPAAGLVFRPDVQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV97</accession>
    <name>A0A7W7WV97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small subunit ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="130"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="216"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="301"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="55056" checksum="3EF49D3FAA0F21EE" modified="2021-06-02" version="1">MSTDTTTVPAATAPKQQIAINDIGTEEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTEGVIPSRELSIKHDVDPNEVVKVGDEVEALVLQKEDKEGRLILSKKRAQYERAWGTIEALKEKDEPVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYVGRELEAKIIELDKNRNNVVLSRRAWLEQTQSEVRSEFLNQLQKGQVRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGQEVTVEVLDVDMERERVSLSLKATQEDPWRQFARTHAIGQIVPGKVTKLVPFGAFVRVDEGIEGLVHISELAERHVEIPEQVVQVGDDVMVKVIDIDLDRRRISLSLKQANEGFTVDSEFDPTQYGMAAEYDDQGNYIYPEGFDPETQEWQEGFDKQREEWERQYAEAHTRYEAHIKQIAKAAAAEEEAAGETNYSSGGDAPAAASSTGGAPAQAGGTLASDEQLAALREKLSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI9</accession>
    <name>A0A7W7WVI9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32015" checksum="A237CC569686E15F" modified="2021-06-02" version="1">MTSAISVSGLVKTFGPTRALDGLDLTVDVGEVHGFLGPNGSGKSTTIRVLLGLLRADGGSASLLGGDPWRDTTALHRRLAYVPGDVDLWPNLTGGEVIDLLGRLRGGLDVRRRDELLERFELDPRKKGRTYSKGNRQKVALVAALASNVELLVLDEPTSGLDPLMEEVFQECVREVRGERTVLLSSHILAEVEALCDRVSIIRAGRTVETGTLADLRHLTRTSVDADLVAVPAELTALPGVHDLVVEGSRVRFEVDTERLDEALRCLVSGGVRTLTSRPPTLEQLFLRHYAEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR6</accession>
    <name>A0A7W7WVR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase class A</fullName>
            <ecNumber evidence="3">3.5.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26703" checksum="200E4E38071AFD4C" modified="2021-06-02" version="1">MTRLSVHVARRGAAPTAAVRDDEQHDAASTVKIAVLGALRGHDPDTPVPVVAEFPSGAGDRFSCDQAADSDPAVWARIGATAPLGWLADRMITHSSNLATNLCALHVGLPAVAGFWHAAATGSTGLARLIDDNAARRTGVHNTVTAADLVRVLWTLTDGELDVLARNVHRVDLAAGLPPGTRIAFKNGWDPGVRHSVGLVWPADAPPYAIAVCYTGPLADGRTAGDPAADVLARISHRMWQRRREPAAPLTAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU9</accession>
    <name>A0A7W7WVU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="25116" checksum="246741D731CB339B" modified="2021-06-02" version="1">MRVVALTGAGRGLGLLTTRVLLDQGVTVVANHRSASPELSALSDKYPDTLHLVPGDVGEEAAGEAIARCAREIGRLDAVVLNAGITRDRPLVSTSVEDWDEVHRVNLRGAFLTTKHALRLMMRQRYGRFVYLSSIAALSGNAGQAAYATSKAGLHGLSQAVAQEYGRYGVRSVVLVPGLLDTGLGAALAPELQQRKIDRSLLGLGSAEQVAATVAFLAGPDADYINATVIRQDGGLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF1</accession>
    <name>A0A7W7WWF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR system Cascade subunit CasA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="537" mass="59141" checksum="9773C0284462849A" modified="2021-06-02" version="1">MTDRVSFDLLTEPWIPVLDLDGDTREVGLVELVLESHRLLRIVGETPPMTAALYRVVLAFLHRACAVADESAWRGLWEADSFHSDPLADYLAKFGDRFDLFDPHRPFLQCPALARIAPATPAKLIPHRAVGNNVTLFDHTTADDVTVFDPAQAARLLVTTQAFDPGGTKTPYQQVKASTQAPGNLLGVVLVEGRTLRETLLFNALLYDPELELPRKTTVEDAPAWEADDPPVPVPQDRPARGWTDLLTWPSRRVLLSHEPGGHRVDGVVITPGVKFTGDLPQHEKMAAFRVSTDLKGKPKKDAPLLPVKLVPQRGVWRHSVELLLADRPGEGRSRLRPPALDQIAGLAARGHLSDAAVYTLRVFGQKLDDNASVVETYLEEAVAAPVALLRAEEPYLAAMVGTAIALADAAGSAVRRLVDGYREERVGKDRKRPKAPPGLDLSYWPNLTRAFDDLLIAVGAAHREHRSEREALSEWADHVAATAREAADRWAESAASDGAEVVVVGKHVEKFHDAVDVLVRTFKAEVRRYLTREQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWI3</accession>
    <name>A0A7W7WWI3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroimidazol reductase NimA-like FMN-containing flavoprotein (Pyridoxamine 5'-phosphate oxidase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="27"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18805" checksum="CA5E2786335E51E8" modified="2021-06-02" version="1">MSTSQPVAELDVRFSDPGIEPTPWADTLALLEGAELFWLTTIRRDGRPHVTPVVAVWHENALYFSTAAFEQKMRNLEHSDKVVATTGNNEWMSGLDVVVEGAATVITDPDLLKVAVDAFDRKYGGDNSWNLELVDGVAQVAGHPAVLLRIEPGKVLAFGKAPHAQTRYRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ2</accession>
    <name>A0A7W7WWJ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="41590" checksum="A62C60CA6F7F294C" modified="2021-06-02" version="1">MFQARWHEDRLLFASRPALFALLRAGRLLGPIRHVPKLGWVVTDPSLARKILNDGAHFTLLGEGGVGHLWAQVLGDYVYRIFDGPGHADLRSRARDLFTDASAQQLVERVFAPALRPARDRLRAGRAIDLADLARVLVGRMMIELLGLDEADDARRVFATGERLAKLALGSATSTTLPRAVIDQARPLIAGLTRNVPRAYAEADPATLLGRCRELGLSEEETTGLAALLMVAGTETAATAMTRIVALLHDTGDQHRLLADPGLLGGAVREGLRVTTPAPVIGRHVSHAVTVGGSSLHKGQRVLLLTHTANNAVGPFDIGRPYAPETRQLWFGAGRHLCLGAALARAEIGHLLHALFEPGRPVVVGPRRPARNVLIPGYESLPVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX66</accession>
    <name>A0A7W7WX66_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20348" checksum="EDBCB23A72BB1EAE" modified="2021-06-02" version="1">MNTTTEPDRLPALIAVYQSDRADRATTLNVGLATMGVAATYLVGTIAFYDKLDLLGWAIALLPFPLICVAAFHSQLLNLAAVRARSILTLERRLLADVPDLDRDRVGTTATERATNVHTAPRPHRVAALIAYGGVSAVHLAYIALMLVKAAQHLHGWVAVPAVVYAALLVPVGAAWRHSARALDFDRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX90</accession>
    <name>A0A7W7WX90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="14919" checksum="AB52870D470FC6FF" modified="2021-06-02" version="1">MATPEEIRQRVEEADTARSARRAAAAQQVGELAQRRAEIVAQLAEVERELGEVVAGAQDVIDVDELAAFTDLKPSDLTGWLAGRKPSRGKRRKATTTTGAHGDVPSSSGSRAQAPEQRRSSGDSPVAARTDTSELIGARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF8</accession>
    <name>A0A7W7WXF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031524101" evidence="1">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="16849" checksum="A5C8609CB09121CD" modified="2021-06-02" version="1">MIRSAVLAAVVALAGSVLVGSATAQAEEVRTASLHGTYACSVPPGYTYARLRDNMACGGVPTSVEYLLLDYVRYDLTGTAACEVPAGLTYTASRTNVACPLKGFYNLEFVLADPAKRNLTGTWACGLPSGYTYQAVRTNGECYAPGTGANPKEYLLLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY19</accession>
    <name>A0A7W7WY19_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ORF">F4559_005314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="28202" checksum="9699704976AFD8C7" modified="2021-06-02" version="1">MGRVTVRRPVVTYARGARRDRVDALAAEEPLELRVAGKALTVTMRTPGQDVELAHGFLLGEGVVGGLADIATARFCAGTGPDGLNTYNVLDIALAAGVEPPDVGVERNFYTTSSCGVCGKASLDAVRLKTRFSPAADAATVTVDVLTGLPDALRAKQKVFASTGGLHAAGLFTADGRALVVREDVGRHNAVDKVLGWALLDGRVPVAGGVLMVSGRASFELVQKAAMAGVPVLAAVSAPSSLAVELAAEQGITLIGFLRGDSFNVYTGAHRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY44</accession>
    <name>A0A7W7WY44_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18484" checksum="DED39A8CE1BD1ABC" modified="2021-06-02" version="1">MNDAMLVVMSGAPGAGKSAIARGIGRTLGAPVISVDPVEAALWRAGIDRTQPTGLAAYTVVEAVAEEVLTGGLPVVVDAVNAVEPARAMWQDLGARHGIRVEPVKVVCSDPGVHRRRLEHRSRGIVGFPEPTWEDVLALEYEPWDVFTVDTVRPLDECVEQAVRHLRAGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY78</accession>
    <name>A0A7W7WY78_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">F4559_005115</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MBB4967756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="22971" checksum="B33796F966CFBA6F" modified="2021-06-02" version="1">MKLALSWLTVLPVRVGSVDAHAARRAIALAPLVGVLLGAAAAGALLALREAPPLLAGLLVVGGLALATRGMHLDGLADTADGLGCYGPPDRALAVMKDGGAGPFAVVALIVVLGAQAAASPVVGPGAVVLALTAGRAAFALCCVRGVPAARPEGLGALVAGSQPVWVAAAWWAALGVAGFFVSPVRGPLAVVVAAALVLLLVRHTRRRFGGMTGDVLGAACETATLAVLVVCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD8</accession>
    <name>A0A7W7WYD8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">F4559_005476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28274" checksum="53057114D42CFB9C" modified="2021-06-02" version="1">MNADAPIGIFDSGVGGLTVARAIMDQLPAERLRYVGDTANGPYGPLPIAQARKHALEIGDRLVEDGVKMLVIACNTASSACLRDARERYDIPVVEVILPAVRRAIATTRSGRVGVIGTKGTITSGAYQDAFEVAKDITVTAAACPRFVDFVERGVTSGRQVLGLAQAYLEPLQRAEVDTLVLGCTHYPLLTGVLQIVMGDSVTLVSSAEETVKDVVRVLTERDLFREGAPDQRFTATGPAEQFARLARRFLPGLETQSFHAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD9</accession>
    <name>A0A7W7WYD9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021449">
        <property type="entry name" value="DUF3099"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11298">
        <property type="entry name" value="DUF3099"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="11689" checksum="889E93A2D8E9485D" modified="2021-06-02" version="1">MGNPEPVLITEAAHSFEDQHAARKRKYMIMMGARFPCLLLAMVFYRTWWLALAFIVLSIPLPWMAVLIANDRPPRKKEEPNRFERERRALEARGHQVIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG1</accession>
    <name>A0A7W7WYG1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10914" checksum="55EA9DF614432A73" modified="2021-06-02" version="1">MPDQNGDLLVLQRLGRTTRDLLPLGQISSRSAKVNILRTTGNPSPPNIKIRCYDRLNLPLAAAAGASTRELMHRMGHGSMRAALIYQHATSERIGRSPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH2</accession>
    <name>A0A7W7WYH2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8672" checksum="26110423BC0189F9" modified="2021-06-02" version="1">MTAYRSTADEAMIIELDPRGNPMLLEENLARSRMHEAEILARHDRLAHRLVVARRWQRLAAWAHRRAQSKSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK1</accession>
    <name>A0A7W7WYK1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="7" type="ORF">F4559_005671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="40748" checksum="5B48CE2F47AA3085" modified="2021-06-02" version="1">MPNMPSLSGLGGLRGRHQDRPAVPIPVPLSAYVVDCGVYVDGARLPGRWSHTEAVKEVRKRGDGFVWIGLHEPDEEQIQGIADTFGLHALAVEDAVHAHQRPKLERYDNTLFMVLKTVRYVQNASPDTANEIVESGEIMVFLGRDFVVTVRHGNHSGLAAVRRDLEADVERLRLGPAAVLHTIADHVVDNYLDVTDHIEDDLDQMETLVFAPRSGVSADQIYLMKREVLELRRAVMPLAVPLRRLAEGYTPLIPEQVRSYFRDVDDHLTEVSERVTNFDELLTTLVDAVLAKITLQQNSDMRKISAWVAIISVPTMVVGVYGMNFEHMPELKWKFGYPVVIAVILVSCLTLYRIFRRNRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYZ3</accession>
    <name>A0A7W7WYZ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002260</name>
        <name evidence="4" type="ORF">F4559_005850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="37972" checksum="D7FAE78A0EE90A38" modified="2021-06-02" version="1">MTHANAPLTELGRLRLARCVVDEGWPLRRAAERFQVSPTTAARWASRYRELGEAGLVDRSSRPHRSPRRLPTRRERRIVKVRLARRWGPARIAHLLGLNPSTVHRVLRRFGLARLAHLDRATATPVRRYEHAAPGDLVHVDIKKLGNIPDGGGHKVHGRRAGGRNSSAHRDPTRPRKVHGRPNLGYAYLHNAVDDHSRLAYTEILPDETKDTAAAFWTRAQAFFREAGVTVRRVLTDNGSCYRSRLWRDTLANAGITHKRTRAYRPQTNGKVERFNRTLLDEWAYAQAYRSETERRETLPRWLHTYNHHRGHTALKGQPPASRVPNLTGQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ59</accession>
    <name>A0A7W7WZ59_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone DnaK (HSP70)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="41944" checksum="67C45C53DDF8DBA6" modified="2021-06-02" version="1">MPYVLGVDVGTTRTAVAVCRTDGAGRAEPDVPLPAVPSALRLTPTGRIAVGEAGEPLVTATGFARRVGDPTPFALGRELCPPEELTALVVRWAVDRVTGHEGIPPEHVVLTHPMSWTGHTRAVMLAALREAGVDRVTLLAEPLAVAENHAFRHGAVGCLAVFGLGGTSSSAAAVRAGAVERWSEDLEPVAGEDFDDLIASHVRAVLGREFEDADYALLRHACEAAKRALSAGPSTVVPVHLPTGVAEVALTRTRFEDLVRPAVEHAVALLARTVRGLPVDVTVLVGGSARIPLIATLVPGRVVVEAAPELAAVRGAALHGRRVLLGDVEPEPRETSVLARDDPSLRFPVGAADQDDDFTAPPPRPPVDIVPLELPVRRTVGRVVRDLASVGRRATGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ82</accession>
    <name>A0A7W7WZ82_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40844" checksum="7E8FC820CD9E2D22" modified="2021-06-02" version="1">MSMSVSGRGNEFVPPTGTPRPAKPTPLLLQGQDYLFRSPPKALDFQEQVHRLGMVEQGDGSPVPCVLVLARSADMEMNELSIALAERGVRMVRVDADRCLDLALTVYTDTPLLELDRWLLRPLLVWRRHFELSALPVEPGTLAAAYATDQWGAVADWLSTRRDFTHVNGVADLDRLTQLADAAAFGLRIPRTAVTTQPGRARPGGAQCIVKTSGKHLLEPRPGVQHGLFPRPLETSRTGKAPESAPVIVQEYVPSETELRVFVVGERCLAFQVDKLDPAQLWIDPEAVRVAPVDVPAALTDKLLALAAHWGLRVAAFDLLVSGGEHVFLEVNVNCDWRWFEHRAEDDRVSTAVHDWAAARFRELAGAGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ87</accession>
    <name>A0A7W7WZ87_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="234"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="41428" checksum="FF658A2E78E91326" modified="2021-06-02" version="1">MLLLRRGAFGPDVAEVRATLTKLGLLTDPQPSQVFDLPVEQAVRAFQQQRGLITDGIVGPATYRALRDAMYRLGDRPLAYMVSQPVTGDDVSALQERLLELGYDAGRATGEFGAQTEQALRSFQRDYGLMVDGMCGPNTVRALRQLQPKVRGGRPVFLREQENVRRAGPRLSGKRIVIDPGHGGADRGIVVDGIAESEVMLDLARLLEGKMAATGMEAMLTRGPDHCPDERQRAVFANEAGADLILSLHSDGNRSPLASGLASFHFGTGNGTSSTVGEALAGFIQREIVARTGMRDCGTHPKSWDMLRMTRCTAVRVEVGYLTNREDRERLADPSFRDVVAEGILVAVKRLYLLGKDDQPTGTFTLSDLVRHELTTGQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE1</accession>
    <name>A0A7W7WZE1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="528" mass="58456" checksum="E2CE3A6AF90D7465" modified="2021-06-02" version="1">MTGRGTSQGDRHDRGRGFARLLLVAALGLALVAAAVLVLSDNARWLRLAVVSALWAALVGAFLAARYRRQAAERDHEVADLQSVYELELEREVAARREYELELETETRKRVREESQDDLTALREELRALKENLEVLLGGEVLVERVALRAEATRMRSLSDQSRLLPAVDQRVITAAPVAKKADPPVERTELIERVAAEAARKEQVRRPEPARPEPVRREPARAAAPQRPAAPQRPAAPRPESTERVTRADLADRLDPAAGATRVDVRPAAEEPRRETPARPAEQARRPDPVPGQVRRTEPAREPARPESRRPEPARAEPTRAEPVRAEAVRPEPARAEAPKPERRSRVAERTAMINPLSEADVARRPEQPAARRAEESGYREPVRPTARTTAPAPRRLADDPAYGAPRRPAEESGYRAPVAPKPAEQRRPAEDSGFHQVPPRRTAAEESGYRAPVAPKPAEQRRPADDSGFHQVPSRRTAEDRVVEGGHRRAESPEPSGAHADGKSVSELLAAFGGADSPRRRRRRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZG3</accession>
    <name>A0A7W7WZG3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22400" checksum="DBCA90BBF96ACF16" modified="2021-06-02" version="1">MDEVEAMTRAGESVGKAVRAVRRRAVQAGHAGADAAVHLAERGQGKLAERGVTADHLRGIVADKAGLLVEKAEAAEKSTRRTRRQLAKKAKAVRKDLLRTAERARKDAKVRTKEIRKAAKQARKDYAKSRHPKGRRWPWVVGILTAGVVAAYVALSRKPEEVLLEDDAFLEDEAFPEPRGRHTDDATLREQAHSARNGQISDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXB1</accession>
    <name>A0A7W7SXB1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (DUF849 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="29676" checksum="A14119B422B0FC02" modified="2021-06-02" version="1">MSRPGTLLTVAPTGAEHAKSDVPHLPVTLPELVETARDCEQVGAAMVHVHIRDDDARPSLDLGRLKDTVQALRTETNLVVQLSTGGSVHDPEADRLRALDALPDSASCTMGTINFGDEVFLNRWEFVVSLHLAMRERGIVPEYEIFDLGHLAALRRLLDRHGLPAGGRVHVDLVMGVPGGMPGDAETLTAALRLLPEGATFSATGIGRTSLPVMFTALGAGGHLRVGMEDTLSYAQGQPVRDNAQLVARAAGLARIAQRPPLSPADARALLGVRDPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXF9</accession>
    <name>A0A7W7SXF9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heparin binding hemagglutinin HbhA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20512" checksum="3BF08E5FC43E9324" modified="2021-06-02" version="1">MSKLPNAEELRKAGEQVAAAARTPLLAALGAGDLAAKAVIDALGKARERVESTQATDLRDKFDPAELRKVVDAYTQSAVNLFQFLAEQGEQTLEKLKNRPELQKAISQVEEVVGTVQKRTEEAASEARDLADDVLGKVTRRTREAGEKVADDVDTVSERVAEAVVDAGGEVAEEVRTTARRATRSRKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXU5</accession>
    <name>A0A7W7SXU5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase/DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="947" mass="101984" checksum="56B1C96B7DF26D33" modified="2021-06-02" version="1">MRFGVLGPLVVWDDDGTPVAVPETKVRALLAELLLAAGRPVSADRLVEVLWDGRERSRNTLQTRVSQLRRALGTRDLVTYSAAGYALRVDAGTLDLLRFRELVSRARTADPVAAAALLDDAVTLWRGDRDDLEDERIAAVEDRAAAHLAIGSTVDVSAEVARHPTRERLRGLHMRALYLSGRHVEALASFTDLRDRLDAELGLEPGPELVRLRQSVLTHDVTRGARPRHNLPAPVSPLVGRDSAVSAVRTLLDRARLVTLTGPGGVGKTRLALAAAHGLTAADGVWLVDLSGATGDRVAAVVAAVLGVRDEGDLVDAVAETLRVRETVLLLDNCERVVDEVATLVSRALRAAPGLRVLTTSQEPLGVSGEALYVVPPLPLPDAMALFAERAAGFLDGDDGTVAAICRRLDGLPLALELAARRVRALGAGGVLDRLDDRLRLLAGGPRDAPERHRTLRAALDWSWDLLGDAERVVLRRVAVHDEGWALDAAEAVAGDDALDVLTRLVDRSLVVAAEGRFRLLDSVTHYGRERLREAGEEDPVRLAHARFHLALAERPGLRAGGQLARLARLDADTANLRAALDVLTGAERVRLAKALTWYWFLRGRLGEARRALAGSADPAAIVWEAAFGVLAGDPLPPDVPATVDQIADPVEEAYTRWFLGYVLSTVGDMPAAEPLTERALRVFEDHGDDWGVAAASIDVVSQSLARGDLVGARAAADRASTLFDRTGDRWGRLQVTFVRGTLAAMAGDYPEAARVHGEGLVLAEELRSWPEVSFTLSWLGRVALLTCDFVRGREYHERARGLAGAFTPATMYAETGLALGARREGRLDDAEHHLHRVLAWHRTEGFESAGTLVLAELGFVAEMRGDAERAAAWHAEGHALASRIGDPRAIALACEGLAGAHALAGDHAEARRLLDEATRLRLSVDTPLPAAERFDVDRIEAVLQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXX7</accession>
    <name>A0A7W7SXX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="10399" checksum="4F6A4ABE45BD078E" modified="2021-06-02" version="1">MEAVVGLVMGLIAIIGVLATLAHDGYLAMLGSAAKKKSAAGAPIAQYVRSRYTVAGVTTAVALFGWLLTTGTGISGDVIGALIAGGGGLAAVNSLQSARKRLNSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY09</accession>
    <name>A0A7W7SY09_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN_10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041375">
        <property type="entry name" value="VapC45_PIN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18478">
        <property type="entry name" value="PIN_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN_10" evidence="1">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14589" checksum="71F1FC64D8E05807" modified="2021-06-02" version="1">MRPEFFLDRGLGRGVAESLTALGWMVHRAAEHFPNDAQHISDEVWLAYGLEHGWSPLCKDGRIKGREAERAPLEVHAAVLFYLDNQRLVRAEMVRRFHDAQQRIYRAAHRGGPAAYAVGSDGIRRTWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY27</accession>
    <name>A0A7W7SY27_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="10480" checksum="9216079A66330261" modified="2021-06-02" version="1">MESGFRVDTAALAQYGSTAGGLAGEVGTVGTSTLSGTTSLAAGSFGALGDEVGLGAAFQRAAQAQVDGVAAGAQGLSAFASEVTKTGQAYDAQEQQNSADLNRAYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY73</accession>
    <name>A0A7W7SY73_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative flippase GtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19500" checksum="70270E336ECE2C57" modified="2021-06-02" version="1">MLSVARRLLGLLPEPLRFLVRKHRELIRFAVVGGTTFVIDNGVWYALKLTILQDKVVTAKFIAVLVAVIASYVLSREWSFHTRGGRERHHEAALFFLVSGLGIGVNLLPLVVSRHVLDLHAEIADFVSGSVIGMLLATAFKFWAMRRFVFPQADARPDTRTKVVPLVTKQRDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY77</accession>
    <name>A0A7W7SY77_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061810">
        <property type="term" value="F:NAD glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="749"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="835" mass="85146" checksum="9434422C74ECE0CD" modified="2021-06-02" version="1">MGIELPPELADVAARTGVAWPRADEDKMRAAATAWREAGTKLTALAGESDGSATTALRGLTGETGDAARRHWNTFVAPDGSLTRTARGCTAAADRLDHAARQIGAAKVEIVRELVNLAKNTEAANQAANAGHPTAGLGLDTLLSGAKANVANLTNTLTSAVRLDSGIDIGNITHPVNPNPGVHQPGGHSGGGTGTPVLGGIVPGGNTSGGIVPGIVPPLTDTVGAVVTPVVDGVATPVTGVVTPVVDPLTGGVVNPVVGGVVDPLVGGVVTPVVGEATPIVGDLVDGAGQVTAPVSEVVTPIVQPVVDGLVAPVTGGVADTVGTVTNPVLDKAAEAVGPVAEPIVREVREVTAPVENVTRDTTQPVADTPPGDRPPVFQAQPQPHPAGPVATPEQPVNLVDRLTGQAPPPPADTTSASSAAAVLDRPVPHAEPAHAAQPTTSTPNQQTPPPAAPAAPAAPTTPSTPAAPTTRGPEPVGPRGGAPAPSAPAAFSSTSSAQSGPAQSGSTQSSSGSGNQPGQSKDPQAKDIQAKEAQAKEAQAKEAQAKEAQAKESGKEPKENKNRDSFFGFAVLPIPASGRDRLVKGTSLPGEATFAPPATAPDAPEVPEQPPYEPVPVGRDAEPADENTAAFLPHMFPGGLLPRPSEKPHLQLPPPSADEAFAAGLRFGPQGHPEGDLVDDTARVRRRVHHGPGHDPSALLTGYDPQAGMHERDWDRRFLVRATPPEYAYPPGELFPEGGYEAGQAGVLGVGTEVDRFGGPEGRVLAETGTPFTARSLPPAVAKAPYHRYRVTRDVPVWFTLSAEWFGQRGGGVRYRTTYPVADLVALGYLEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYA8</accession>
    <name>A0A7W7SYA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33162" checksum="0C9E49B2DCBCF2A9" modified="2021-06-02" version="1">MSAGGGTKAIIAALVANAGIALAKFVGFLVTGSSSMLAEAVHSVADTSNQALLLLGQKTSKREATRNHPFGFGRDRYFYSFVVALLLFSLGSVFALYEGIHKLEAHEPLSSPLVAVIILVVAIGLESYSFKTAIAESRELKGDATWWQFIRQSKVPELPVVLLEDAGALFGLVLALFGVGLSTLTGDPVWDAIGTICIGALLGVIAIILIVEMKSLLIGEGASPVELDTIVDELAAGKVQRVIHIRTQYIGPDELLVAAKIALNPGLPAADVAQAIDDAEQRVRNKVPAARLIYLEPDLDRSLPENKVAGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK6</accession>
    <name>A0A7W7SYK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030843226" evidence="3">
        <location>
            <begin position="29"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="5">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="234"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="522" mass="54045" checksum="1562242B3418BC2E" modified="2021-06-02" version="1">MKPRMGALLAASALAMGSLLVVGAPASAAAGVTATFAKPQDWGSGFEGKFTITNGGTTALSSWKVEFDLPAGTTLGSYWDAIITKDGSHVTATNREYNGGIAVGANRTFGFVGTGSGVPQNCKINGASCAGGEIPNDPTPPSVPTGLTVTGKSSSSVSLSWTASTDNVGVTGYDVTVAGGATTTVPGTTATVNGLNPDTSYSFTVKARDAAGNVSGASTAVTAKTDPGTTPPPGNRGAPYLYLGWGNPPSPASVMNATGIKWFTMAFILAQNGCNPSWDGQRPLTGGNDANVINQIRAAGGDIIPSFGGWSGNKLGPNCSTAQALAGAYQKVIDAYKLKAIDIDIENTDEFENATVADRILEALKIVKQNNPGIQTIVTIPTLKTGPNSHGNRLIERSKAIGSNIDVFTLMPFDFGSTDIRTDTINAVTALKDKLKSTFGWTDAQAWAHSGISGMNGLSDQKEVTTPQTWTALRDFAKSNGLGRFTYWALNRDRGGCDGQVSGSCSGVPQQEWEFTRITAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZD9</accession>
    <name>A0A7W7SZD9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LCP family protein required for cell wall assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="95"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="40161" checksum="464F5C4E29E1E1B2" modified="2021-06-02" version="1">MKAALVVGRALVVLLSAAVLAVSGYTWSTLRRVQDSVNTTDVIAKLSEVPNSPPADDGALDILLVGSDSRTDAQGRPLPADVLRQLRTEATDTLNTDTIIVLRVPRDGSRAHAVSIPRDTYVPIPGLREEKINSAYGLTKFHTMERLQQEGVHDLDERSQRGDQAGRLALVQVVQDLTGVRVDHYAEINLYGFYLLTQVIGGVEVCLNNATSDPDSGANFRAGVQNIAGGDALAFVRQRKNLPGGDLGRIARQQVFMSAAVSRLLSAGTLTDPAKLSGLLDAVRKSIVVDEGFDLATLAGQAQGLAGGNVGFATIPVTGVGARNDRGQSVVTVDPAAVKAFVAQLLGPKDPTPTARKLTGGLGLSLDGGPRRVALQGPPCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY6</accession>
    <name>A0A7W7SZY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator GlxA family with amidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="212"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="34147" checksum="A9DBEF10329F2969" modified="2021-06-02" version="1">MLHRVAVPLIHGFAPFEFGVVAEVFGVDRTEDGVPPFDFRVCTATPEPVRSSIGVSVLADHDYSALLSADLVAMPAVRVRDEYPADLLDALRTAHRRGATLLSVCSGAYVLASAGLLDGRTCATHWRYAADLAARFPKVRVDPDVLFVDEGDVITGAGTAAGIDACLHLVRRELGSTVTAAIARRMVVAPQRDGGQRQFVQEPMPVRADSLQPLLAELMGELADEHTVSTLAGRARMSERTFARRFAAETGTSPHRWITAQRVLKARRLLEESNLAVEQIAHHCGFGTAALLRHHFTALVGVAPKDYRRTFAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C1</accession>
    <name>A0A7W7T0C1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22620" checksum="406135F86F3EB9E0" modified="2021-06-02" version="1">MAPTHTPWGTWDPITPTEVAGLFAGVGFPWWVAGGYAVELAVGRPVREHVDLDVLLLRRDHLAIQDVLAGWEWWAADPPGVLRPWRPGERLPVDVHDIWCRPDADQPWRVQFMLAEAEDGTWISRRDPDLRRPIATLGGVDGGGIPFLSPEIQLFYKAKGLRPKDDADFAAALPVLTADQRAWLADALARTHGEHPWLPLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H6</accession>
    <name>A0A7W7T0H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030642536" evidence="2">
        <location>
            <begin position="29"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="590" mass="61822" checksum="F0E3E51EFD9FDB82" modified="2021-06-02" version="1">MKRWGRVCGAVVVAGVCAASAVPSGPEVEEPVVPTGDPALVAYDSCDTAATALRRAILPHVTEYGLGGPYLTMERTVGDAAPPTARTPEHSTTNRHEAAADEPDLVKTDGRRVVSVVDGRLRVLDVASGTVAGLSDLPGPATGVLLHGDRALVFGVATGDPVDRRIMVDATTVTLVDLSGPPRVLGTLDVDARFVDARQVGDVVRVVVHSAPNLPFGYPDGTVTPRESLRRNQEIAASAPVDAWLPRYRLAESGARSEGALVACDRISHPDVPSATSLLTVLTFDFPGGLGTGDAVTVLADGDTVYGTGTGLYVADARGAGFAPATVTAVHRFDVSRPGPPVYAASGEVPGVVLNQYSLSEHDGLLRVATTLEPDATRTRSSSTVTVLRQEGDKLVKVGAVDGLGHGERVYSVRFAGPVGYVVTFRQTDPLYTLDLSDPAKPRVTGELKITGYSAYLHPAGDGRLLGIGQEADERGRVRGTQVSLFDVTDPEAPTRLAAYHLPGTHSEAEFDPHAFLYRAPVLAVPVGQGVLVLDVADRAITARGTVSHPIPGGSLRSMVIGDELWTVSHAGVRVNALDGLAERAWIPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T181</accession>
    <name>A0A7W7T181_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="25297" checksum="C1A86BDE647F1057" modified="2021-06-02" version="1">MKNTGTDSTAVPAGHDGRTRHSVARLLLEQGPVTAAAVAEQLGLSPTAVRRHIDALVADGEATSREAPRRGTRGRGRPAKLFLLTEQGRARFGHAYDDLAVAALRFLAEQGGEEAVRAFAGRRVAAFVDRHRAAIVAQPDAAGRAKALASALTREGYAASARHVGAGEQLCQHLCPVAHVAAEFPQLCETETAAFAAVLGTHVQRLATIARGDAVCTTHIPNTPRTTLGDAENRTAVGGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A4</accession>
    <name>A0A7W7T1A4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding FrmR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10109" checksum="8399817220D456A4" modified="2021-06-02" version="1">MHGYTADKDAYLKRLRRIEGQVRGLQRMVENDDYCIDVLTQISAATKALQAVSLGLLDEHLKHCVAQAVAEGGEVAEEKIAEASAAIGRLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A6</accession>
    <name>A0A7W7T1A6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LSDAT_prok domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041482">
        <property type="entry name" value="LSDAT_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18171">
        <property type="entry name" value="LSDAT_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSDAT_prok" evidence="1">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="21202" checksum="C00D4D23AC1E8244" modified="2021-06-02" version="1">MRRVRVGEVAGLPWVAGLPAGRPVLVLVGGAAGMADAHFDLVAGVLADLVPVLDGFGAVVVDGGTDAGVMRAMGSARAAAGGDFRLVGVAAEGALGKTPLEPHHTDVVLVPGDRWGDEVPWLADTATAVAAGLPSVTLLANGGLISLDDAESSLARGRPLLVLRGSGRTADAIAARADERTARIADSPLTHVVTADRVAARVARAFTTTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A9</accession>
    <name>A0A7W7T1A9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24479" checksum="91564FFC4E6FE756" modified="2021-06-02" version="1">MGQASVQAAIDVDAFDGRPDVVADVRPAPSRAGLRWPAEPELTELVDVALTGDPRAVERLLARLQPLVLRYCRARVGTRERTLVSADDIAQEVCLAVVSALSRYRYEPGSFLAFVYGIAAHKVADARRRAVRSRSEVVPELPDTPTLEDGPEQRAMNGELIQRVTLLLRRLPERQREILVLRVAVGLSAEETAVAVGSTPGAVRVAQHRALARMREMFAAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P7</accession>
    <name>A0A7W7T1P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AmiR/NasT family two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012074">
        <property type="entry name" value="GAF_ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036625">
        <property type="entry name" value="GAF_ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="174"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25915" checksum="1573EFEF8D997C49" modified="2021-06-02" version="1">MSIDDVPTNQLDEASAALEELVGILAADQSLSDALQQLAESAARVIPDAQNVSVTVLDADGSGHTAAATDQVVVAIDRDQYAAGEGPCLEAAATKRPVRVTAEGGRERWPAFAAAAAEAGVRAYLSAPLILDDRVIGALNVFSADEHAFDPFDEALLRLFVTAASTTITGFRRYERSRGLIQHLQNALESRAEIDQAKGVLMAAHGVSAEEAFARLVQESQQHNTKLRDVARNLLGSVRRSVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W9</accession>
    <name>A0A7W7T1W9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18082" checksum="3157B79FD45ED5C7" modified="2021-06-02" version="1">MAASPPTGRYSIYTGRVTNWPLVVVLGTALLVPLLLLGTLSRGDRLDPAGPAIPLAVAAGALLVLVLTGLNVRTAAGPNGITVRCGVLGRPRRTYRLADVDRAEVIDLKPTLSRVSFGYWWTPRRTFYTVRTGPALRLTLHNGRSVTITVPDPLAAITAIHEAKGQPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T284</accession>
    <name>A0A7W7T284_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15386" checksum="BEB8A8CC25EEF690" modified="2021-06-02" version="1">MTVAELEASTEIDVLVEHHWFGVGDPDSTEDTPIPDPGAWFAAGDSLVMFQSEEDIVRARLHLEWHTDRPPLDSAQWPHSTEIDLHLPSGVFTVDEGVAGVTGPVFTVPAGRYRARLGWRPAPPSTTEPEAYALVSFWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M7</accession>
    <name>A0A7W7T2M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS30 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="44" mass="5197" checksum="3284D38E0A20393C" modified="2021-06-02" version="1">MARLRRIVERMEAARRAGWSWRDVASRLGVTKQTVHRKYGREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N9</accession>
    <name>A0A7W7T2N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional repressor of nem operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="19929" checksum="1E79DA080988ACB5" modified="2021-06-02" version="1">MGRVDTQGALLDHATRLVRTKGYAAFSYADLAEAVGIRKASVHHHFATKEQLGVALVAGYTERFRARLSDIDRQATGPVDALERYAALFRDGLSDGEACLCGVIAAEIAAVPPAVAAGVAEFFDVNRTWLTALVEAGRRSGALRPRRTSEEHAAALLAALEGAVLIARAHGDVAAFDHVADAMIAALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2P2</accession>
    <name>A0A7W7T2P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16345" checksum="991B8415E4B16CA2" modified="2021-06-02" version="1">MLMRTDPFRELDRLTQQVFNNVAGTWSRPTAMPLDAYRAGDEFVVAFDLPGVDPDAIELNIERNVLTVKAERRPTVTDQSVEMQVSERPLGVFSRQLFLGDTLDTNQINADYNAGVLTLRIPIAEKAKPRKIEISGGQATRKEINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3B8</accession>
    <name>A0A7W7T3B8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11962" checksum="0900B78E5F9FC258" modified="2021-06-02" version="1">MAANNLDNLDDLDYPAFTTGQAADLLGAQQAFLRSLDTANLLRPQRSDGGHRRYSRRQLQLAARIRTLFDEGHSLAATARIIGLEDDLTAAHDQIADLRSQLDNDTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C7</accession>
    <name>A0A7W7T3C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="31943" checksum="3C81D6FB8252845B" modified="2021-06-02" version="1">MVDFDYPAGRFTAFLNARGVEVRRIIAFAGLSTLALVDSADAPGEPAVAKGLSGYYHVIHDAPPERQPGTYGYYWYKRYGPEQYAAWHTAFRFEYETLRALRGSPGIVEVSTGDMDAAIPYYLMRHHPAGSLAHHAGSLGWDLDADFVLTVARDVAGGLETLHRRGVAHRDLNAENVLLTEEGHAVVADLGCARDVRSGPLGPARRPDEFHWPPEYATAYDTADAKADLYALGVLIHQMTTGRMPRYLGPSCVAAAPAGRFPAELLKIADACLEHRPENRPEAADVLARLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U0</accession>
    <name>A0A7W7T3U0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alkaline shock family protein YloU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="16339" checksum="E2250333FA520B05" modified="2021-06-02" version="1">MTSPTMSKPPTRNENTEIPPREAGTTSPPQGTTTVADTVVQKIAGLATREISGVYALGGGAARAFNSLRERIPGATASAGQGVSVEVGERQAAVDVHILVEYGVSITDLAHSVRRNVIGAVEQMTGLEVVEVNIVVTDVHIPGDDEGDKAPDTGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V1</accession>
    <name>A0A7W7T3V1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20960" checksum="909EB6076F12A031" modified="2021-06-02" version="1">MNPIVAQVLTIVGVLLGSAATFIVTSTTERTRWRRAQAARWDDKRLVAYSEYANAVKHMLRLCRRIAETRGLLSTGQPVDLGSSFADLAEAETDRAARWETVLLLGEPDTISAARAWSEEVWRVEHILRQDRPESSSFAEAYRAAMRLRNEFYAHARADLGITSGALPELVWKSLQPSSADESRDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T400</accession>
    <name>A0A7W7T400_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="3">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdxS</name>
        <name evidence="6" type="ORF">F4559_002249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="5">
        <location>
            <begin position="13"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribose 5-phosphate binding" evidence="3">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="31773" checksum="3EBCADCB989DDEF9" modified="2021-06-02" version="1">MTTSPDSAATGTARVKRGMAEMLKGGVIMDVVTPEQAKIAEDAGAVAVMALERVPADIRAQGGVSRMSDPDMIDGIIEAVSIPVMAKARIGHFVEAQVLQALGVDYVDESEVLTPADYANHIDKWQFTVPFVCGATNLGEALRRITEGAAMIRSKGEAGTGDVSNATTHMRKIRAEILRLQNLPADELYVAAKELQAPYELVREVAEAGKLPVVLFTAGGIATPADAAMMMQLGAEGVFVGSGIFKSGNPAQRAEAIVKATTFHDDPDVLAKISRGLGEAMVGINVDEIPQPHRLAERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B2</accession>
    <name>A0A7W7T4B2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="680" mass="73866" checksum="89CA0934534DC2FF" modified="2021-06-02" version="1">MASIGGVLWLLFSASDRSVVGTVIQAVSAVLVPGSALGVWMLRRRVPRTPDLDAAGDGLAVAVRARWERTATELRLIYPTRISVRWSWSDRTAGGSRIDAVGSPVTPSRVAVLPGARPVGPLQVEDGDLGGLFDVFAGLDSGRILLIGAAGAGKTSAAILLLLEVLRHRDGTADRHRVPIPVLLGLADWNAARHRLVDWAAARLELEYPFLVASEYGRGTARRLIESGRVVLFLDGLDDLPERLRPVAVRALDLQATGRVVLLSRSAELVQAVAEGGHVAGAAVLELLPVTGDRAAAYLELCRVDPPPPGWRRLVDHVRRHDDAVTRALDTPLMLSLVRDAYRPGDDMADLFPTGGFADRTEVEHHLLERFLAVAYAPSPGQPAPRYGLDQATRWLGCVAAQMNEDNSPELSWWTVHRWRPRWIRVVATGLSVTFVLGIVLGAIVAGRTDAALLSYATVFALVLGAVYARGVGQPRQWSRPLRPELFSRENFKAASLFSVTTFLMLSMTLSVWLGRDYGIMAGLLCGLAVGLTSFLFYSIARPSVDQFSPIPPATCWYREIRYRIAFGLAVGVLGGAMMTLAELITSDEGVDDVTASLLGQLAGTVPYGLVFGVVSSKTWVAFLVFCQLRVEGAGPLRMIDFLEDACARGVLRTVGPFYQFRHARLQDLLAASWHERGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T513</accession>
    <name>A0A7W7T513_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19197" checksum="485D01894170B0CF" modified="2021-06-02" version="1">MGEYVTVAAVMTVARPRVREWLRAAVVPASTWTDWSGVEGWDDAAVAECDRWLEGDYAGLLHELVDDSGLRIGFDEATGSLTVDFDARVDFRLPSLIWAFTVFRGLADVMVDDDAGLVTVTGDWDDAPVALHLSPGRSEFVRGAALARAADLEFDVRCAVGDVDDPATEVLDRLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E1</accession>
    <name>A0A7W7T5E1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="28805" checksum="B51F5509AFBA9E5D" modified="2021-06-02" version="1">MGLRFREGMIGTNPCRKLRITFDPRPERPHATTDEVDALAARMEPDDGLLTTTAAYTGMRWGELAGLQWTRTRLDDNPRIRVDPEFGALHEVRGRELELSPPRTAASARLVHLPPFLAEELRAHRERNPDSRFVFPGARGALRRRSNFRQRVWLSALAGDETRGWAPLNREMHFHDLRHTHETWLIEEGVPRVLRLERLGHKRKDVDDDYSHVTDVMIARMLKALQHRWETDGGWRWNQREEHPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J6</accession>
    <name>A0A7W7T5J6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="PTHR37489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030568093" evidence="1">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="35410" checksum="DFD9EFF6DAB37FC0" modified="2021-06-02" version="1">MAPTPLPTGGATASVSFCPVASATTDVPAPAGEAALAATESFLATLDDGQRTAVLAERTDEALARWSDQPDPLFDRAGLRMDALTPAQREAVLKILAAVLSPDGYAQVNAITTADGVLAAGGVGDLDLGADHYWISILGTPAATGKWTVQYGGHNLAVNVTLSGNDLTIAPTFWGAQPVSYTTDGITAEPLCGEVSKAFDLVGTFDDDQRAAAVLPAPVGEVVLGPGQDGKTLAPAGIEGAALTDGQRELLLALVEEWLRPMPAETAAAKFTAVLENLDRTTFAWYGDTKPGQPVYYRVQGPTFTVEFAYQQSQDAEGLMHIHSVYREPGNDYGAQFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L3</accession>
    <name>A0A7W7T5L3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional isochorismate lyase/aryl carrier protein</fullName>
            <ecNumber evidence="2">3.3.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001111">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="23119" checksum="BFBB060BC93FFCA4" modified="2021-06-02" version="1">MGLPTIEPYPMPTEADLPANRVDWTCVPARAVLLVHDMQNHFLRAFRSDSSPVVELVENIRALTATARALGIPVVYSAQPGGQSEDQRGLQLDMWGMGIADPADAGIFPAVEPDASDVLMTKWRYNAFHRTGLREMLDAQGRDQLVVTGIYAHIGCLMTAADAFMQDIQAFFVADAVADFSPDDHRMAVHYAAGRCAVTTTTSRLIAELETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M9</accession>
    <name>A0A7W7T5M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent ferric siderophore reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="29834" checksum="C9F29C26C2CD09B7" modified="2021-06-02" version="1">MAVPNVEVVQYDLVPRVLRVRAVRRLTPRMVRVTLAGEDLAGFREAAPADHVKLFFPTERGGRPAMPKLGPEGLERDPNGPRPTFRDYTVREYRAEPGELDVDVVLHGDGPGSTWGAQAREGDTVGVLGPRGSVLVPKGLDWYLVAGDETALPAVARWLEQASEGERVFAFAEVADEAERQEIASKGDVELTWLYRDGAAPGTTTLLHDAIAAWELPEGTGFVWIAGEANTLKPIRRLLRDRGLHRDAMDVDGYWKRGEENFDHHGPQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P6</accession>
    <name>A0A7W7T5P6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-lysine exporter family protein LysE/ArgO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="20599" checksum="B3706F38372382DC" modified="2021-06-02" version="1">MMYAVLAGLGTGFSLIVVIGAQNALVLRQGVLRQQVAVVVALCAASDAVLITVGVAAGSLSVPPAVLVVPRVGGAAFLLYYGYSAFRRAFRASALEPAAQPAATVVLTCLAFTWLNPHVYVDTVLLLGTTSTTWGADRWWFGVGAACASVTWFCSLGFGARHLAPLFTRPVAWRVLDGFVAVITTVTAVSLLTAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S2</accession>
    <name>A0A7W7T5S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="32038" checksum="705B64FEDDF0592F" modified="2021-06-02" version="1">MRNVIEVTGLRCRYGDFEAVRGIDLEVAEGELFALLGTNGAGKTTTMETLEGLRAPSAGTVRVLGVDPFADRDTIRARAGIMLQESGFPADLTVAEMVRLWSRDAGDALDRLDLAHRRDVRIKQLSGGERRRLDLVLALLGRPELLFLDEPTTGLDPESRRRTWDVVRGLLAEGTTVVLTTHYLEEAESLAHRLAIMDRGAVAVSGTLVDVLAAQPARIVFDMPGRLGVEALPMLAGDVVHEPSGRVEVRTRELQDDLGVLLAWADREGHRLSRLVATHASLADVFHRTKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S9</accession>
    <name>A0A7W7T5S9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="651" mass="70212" checksum="A6397B47F125C534" modified="2021-06-02" version="1">MPEYAIPAEVDSPVRPVTPGSRLGRWLLAHRVAPAGPEADRHHNPKPWWQILCLTGVDYFSTLSYLPGIAALAAGALSPLATLLIVVLTLLGMLPMYRRVARESPDGQGSVAMLENLLSFWRGKLFVLVLLGFVATSWIVTITLSSADATVHLLENPYLPEFLHGKAVAITVVLLLVLGGVFLLGFSEAVLVAIPLVALFLLLNAVVVGAGVVELVTHPELTADWTDRLGRGDVVGPAVLAFPLLVLGLSGFETGVSMMPLIKADGADPAERLEHRVRNTRKLLTTAALIMSVYLVATSFITTVLIPEEAFQEGGEANGRALAYLAHRHLGEVFGTAYDIGSVLILWFAGASAMAGLINIVPRYLPGYGMAPEWGRAVRPVVLVYTAICVVLTFAFHADVNAQAGAYATGILAMMVSASVAVTISAWRRRRHASGVGFTVLTLVLLYALGENVREKPDGIAISGAFVLGIVVISLVSRVSRTTELRADRIEFTELARRFVTESLAHDGTLNIIANKRQAGDDAEYRHKEATQRGLNPVPGRAAVLFLEVEVVDPSDFSDVLRVRAIEVDDHRVLRVESPAVPNALAAILLALRDATGVRPRCYFEWSEGNPLAHLFRYLILGQGDTAPLVREILRKCEADPARRPAIHVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T2</accession>
    <name>A0A7W7T5T2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="37275" checksum="864D9F6F65CFABB4" modified="2021-06-02" version="1">MPAATALLVRPDVLNALWMELHHPRSTAHRMHHVTRCDTALRADGVRLGARHDGPTGSGLRLAGQCPCRDLVADALEIAAGFLAGHGDGLANPAGAVRQHLRFRMTDAGRRERRLLGAQVKPGTVARNRYGTALPDDFHRALYVLIADEAGVRGPLRGEEGLRRRLADRCTAELGIGPEEARRRLPAALRLIESTCRRGPRVNVGTRRDPELVSWWDAYVERPLGRRPDPTVLTLPHQTGADDRAGAAEVRDPHAENAFDRVLTTVALRGTDIAADSPEEVVVAALRQTVTSTPPDRTDDAVSHVVTLLRDRGLLPENRARLLLDDPAHRRRVIACARALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U4</accession>
    <name>A0A7W7T5U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="92" mass="9830" checksum="AAAAF6CCFF533E15" modified="2021-06-02" version="1">MSKLLYRPLGLAFGLLGGFLAGKVFDRLWKLVSGDRVAPTPTQKDRGWGEILLAAALQGAVFGLVRAAIDRAGAIGYDKLTGEWPGDTQDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B3</accession>
    <name>A0A7W7T6B3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20819" checksum="BECA37E324720244" modified="2021-06-02" version="1">MYLVGDGEGELSGPITDDELVSLHWDRDQAVDLDALRGVLDQSRVTAWSGTTIGRNESHDGLWLRLTVTDPRVCRIKVHADVPPEVCDPVRGWWRMALVDGDTLVYLTARRLESGDEVRWELGAIGHGSAASELTEYLCDEIRSWAPKRNQHTPSLIVYPAGTPDSELAGPAIDKTHSRFVLTYDPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L8</accession>
    <name>A0A7W7T6L8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00937">
        <property type="entry name" value="2A51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="37649" checksum="1FDF30E03EB91D22" modified="2021-06-02" version="1">MTRVPVAIIAREWLRIGCVGFGGPPAHIALLRDLCVRRREWVDEREFEDSIAVTNLLPGPASTQLAILCAWRLGGVPGALVGGACFILPGLVLILALAALLLSTAAPAWVLGAAAGAGAAVPAVAAHAAATLVRGSLRQVGPVLSARVRWAAYLLVGGVAAAVTGPWLVLVLVAAGLVEVSVRAPLGRRSAVPLVLALPAVGGGLGAVAWVAAKVGALSYGGGFVIIPMMRQDAVHTYGWLSDERFLDAVALGQITPGPVVQTVAVVGYAAAGLGGGLLAALVAFAPSFAFVLVGGPRLDRLRANATAKAFLTGAGAAAIGAIGGSTLPLALSLHRPWQFVVLGAAAVWLLLLRRGVVSALVVSSVAGALITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P9</accession>
    <name>A0A7W7T6P9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="334"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="517"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="703" mass="75022" checksum="C0F5AB3626EB5056" modified="2021-06-02" version="1">MSTPTAEQAKELFPDEVVTTARTRLVSVPGLAGRVALITLDNGHDHTRPSTFGPQGLVSLAAAFDEAAAADPVAIAVTGKPFVFAVGADLSAVEHATRREHALFIGELGHDVFRRFTDSKIPTFAFVNGAVMGGGLELALSCHYRTLASNAAAIALPEVFLGLFPGWGGTQLLPNLIGPDAAVTVIFENALNQNRMLKPEQAFGLGIADVLFESADYLERSLEWLAGVVRGEIPVPRKEIDRGAGWDAALARAKGIVYGRTKGATPGALKALELLALARENDLDRGYAAEIEALADVVMGDELRAGLYSFNLVQKRAKRPAGAPDKALARKVTKVGIVGAGLMASQMALLFARRLEVPVVLTDVDQARVDKGVGYVHTEVDKLLGKGRLSPDAANRLKALVTGSLDKAAFADADFVIEAVFEDLDVKRTVFAEVERHVSAEAVLATNTSSLSITDMAAGLAHPERVVGFHFFNPVAIMPLLEVVRAEKTDDATLATAFAVAKQLKKSAVLVKDAPSFVVNRLLTRFMGEVVKSIDEGTPFEVADRATESLGLPMSPLILLQLVGPAVALHVAGTMHRAFPERFAVSANMKAFVEAGKTAVWQWDAAGHQSVDPAVQELWRFGDHPSTGDEVRSRALEALAEEIRFMLDEGVVAEAQDIDLCMILGAGWPFWLGGVTPYLDRTGISEKVTGRRFLPPGVASVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6V4</accession>
    <name>A0A7W7T6V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="33161" checksum="C5C4B15A96CDB9A4" modified="2021-06-02" version="1">MTAGSASAGPAVVDACAITDPRLAELSGLGSDGTSWYAVADSDDGRIEVQVLDRSCAITRTIVGATDPFDVEDLALAPDGTLWLADTGDNRRSRQTVALHAVSPDGTTRLFRLTYPDGAHDAEALLLDGAGVPYIVTKEAFGSPLVYRPTGPLVPDGTEPLEQVAKLSLPGSDTTGGPAVGSVVTRVVTGGAMSRDGRVAAVRTYTDAYLYPVVDGDLATSLEADPVRVPLPGEPQGEALAFDPDGTLVSASEFGDTGASSAVRTVAGAAALAVPAPPPTTTTTAAPPASARSVDAGESVSPVWVIGGGLGALALLAFLVRRRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W1</accession>
    <name>A0A7W7T6W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="469" mass="50059" checksum="C3A2CF644F9AD65C" modified="2021-06-02" version="1">MRREHVDDLVVVIPGILGSRLAVDGKEVWGTSPGAALRAIRTFAGSIKDLRLPKDIGDGHPGDGVVPTGLLPSLHALPGVWPVVDGYGSLIDWLERTFTLRRALPGDGPDTAVNLVEFAYDWRLSCRYNAHLLSIRVDKALGRWRTRHPDAQVRLICHSMGGLIARYWVECLGGAEVTRLLVTLGTPHRRSIGALASLVNGDRVAGVDLTAFSRSLPSLHQLTPDYACIESPDGLRTTHELSTTLDGVDANLLADARRFHDEIRTAALGRVAAGGSDRLCRPVVGVRQPTPTTAAVVDGRLRLIETIEGKDEGGDGRVPRFAAYPAEVSLDDPAARSSFANHGAIKRHAGVRGDLYDALAPEPGVYRGAEPGHPLGVRVPEFLAPGEPLRIEAEAVTGGRGSDRLAVRAVVEPEDGRAVTRVLRNLGDGRYEATVDGLSPGAYAVSVHASSDQPSDAVTAMTLVLEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T710</accession>
    <name>A0A7W7T710_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8961" checksum="23B8EBFD3A6C4945" modified="2021-06-02" version="1">MSCQRNANPRQLDSLRCPGRQPGTYLPRKLHARESLDASASAYRSSGAVHNALEKLGDSGYAVRTCDKPRKYSLAATAAAPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T769</accession>
    <name>A0A7W7T769_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N-(2-amino-2-carboxyethyl)-L-glutamate synthase</fullName>
            <ecNumber evidence="5">2.5.1.140</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family. SbnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.140" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023927">
        <property type="entry name" value="SbnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03945">
        <property type="entry name" value="PLP_SbnA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="39"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="38542" checksum="60E71F19F658C7E7" modified="2021-06-02" version="1">MTELLATVRGRDPLGRVASLPGLTSVDADDGPRFGGVLSTVGNTPLVELTRLMPHLDIRVFAKLEQFNPGGSIKDRSALSMLGNLVELGELVPGRSTVVESSSGNLAVGMAQVCGYFGLRFVCVVDGKTNRQTLSILRAYGAEVEVVTERDPATGEFLPRRLARVRELLAEIPHAYWPNQYANPRNPAAHEQTMHEIANAMNGRVDYLFCSVGSFGTLLGCSRYIKNYGLNTEIIGVDAIGSVIFDGQRPSPRLIPGHGASVRPALYQDGAADHVIHVSDLDCVAACRRIATTEAILAGGSSGATVAALEHFADRIPAGAHVALVFPDTGDRYLETVYSDSWVTERFGAVPGLAEAVTNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T783</accession>
    <name>A0A7W7T783_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like chromosome segregation protein Spo0J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="31370" checksum="C06C9A50B5354D75" modified="2021-06-02" version="1">MPEFGADRTVPIGSLVLAGSPRLAGEDDAHVRVLADTDAALPPILAHRPSMRVIDGRHRVRAALLRGEEEIRARFFDGDDAEAFLLSVSENVAHGLPLSRSDRAAAVERILRHTPEWSDRAIADATGLSARTVADIRRRATAGTPQSHTRIGRDGRRRPVDPAAGRRRVGELLAANPDASLREIARAAGVSPGTVRSVKERLRAAPEEPPPVADPGALISRLRQDPSVRFNEANRALLRLLDAHASTDHAWPRFASQLPEHCTELVRTLARRYAHRWAELAEELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E3</accession>
    <name>A0A7W7T7E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21709" checksum="FF7BA1471A37D8B6" modified="2021-06-02" version="1">MSIQGIQTLCDLRAIALAAETLIRWKSPDRVITSMASGYNQRMAEPRRDGLLSGDPGQAERSIDDWVEGMRSRADRLQALRDQVERIRVTETSVNGAVVVTVDSTGSPVDVRFTDRTTSVRPDDLGPLFMSTLNAARARIAGEVQAATESQVGDDLPDTRRMVVDAYRDRFGDAPPPAPRARRRDDDDFGDDSYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E9</accession>
    <name>A0A7W7T7E9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase D</fullName>
            <ecNumber evidence="4">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031030164" evidence="1">
        <location>
            <begin position="32"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="147"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="29375" checksum="EA93CFE358CCE315" modified="2021-06-02" version="1">MTEGVVNRRTLLRAGAIVPAAMLLPAGVALAHGKNRPVLTHGVQSGDVTADGALVWTRADRPSRMLVEVSSDPSFRHRRVVRGPLLTPETGGTGKVRLRGLVPGRRAYYRVVAEDLDGRTRSEGVVGSFTTPPLLRRDVRFVWGGDVAGQGWGSNPDLGGMPLFAAMTARRPDFFVHSGDTVYSDGPLQEKVTLADGRVWRNVVTPEKLKVAETLDEYRGQFAYNLLDPKVREFAAQVPAYAQWDDHEVTNNWYPGEILDYCLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N8</accession>
    <name>A0A7W7T7N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7219" checksum="445F9B9AD83891FF" modified="2021-06-02" version="1">MAQSKEWQISCRDIASRRRDMTVFVSQGHVVVTVPPGEAAVLTPLEVGRLRAALRDAVVTASDAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P2</accession>
    <name>A0A7W7T7P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LCP family protein required for cell wall assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="274"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="543"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="666" mass="71288" checksum="ECCAE0959072096E" modified="2021-06-02" version="1">MDDRPPWQQSGPPGDRGRPVPPRGPVPGRGEPPRRRQPRTPQPDPHQNDPRREPPRRETPADRRRDLAGGRPRPDAPRREPQRRPRPEEPAPRRPRADEPRRADSPQRGFRSEEPQRRPRTDDQRRSRASADEPRRSRPAADEPRRSRGEAPAAGARRPAGQRSTTRSSTSTRRKAPTSTPKPGSLVGRSIAVACSLAVLIGTGYGWKNLNALTENLSTRDVISAEGGGERPADGSVDILMVGMDSRTDAKGNPLPQNVLDELHAGDESAGGLNTDTLILMHVPNDGGKAVAVSFPRDSYVKIAGGYGRHKINSAYGYAKNDALEKLQDEVADPAAREVQSNQAGAKNLIKTIEDLTGVTIDHYAEINLVGFYDITKAVGGVDVCLNQATQDDFSGADFKAGPQKIQGREALAFVRQRHGLLRGDLDRIVRQQVFMAGLAKQVLSAGTLSDPGKLSDLIGALTKSIVLDKDWDVLQFATRMKDLTGGNLKFETIPTGDPELETPEDGQAIEIDEGDVRRFVKGLNADPNAPAPTGQTVDPATVTVEVRNASGTPGLAARVLEVLVAKKFVDGGADNADEGMSRSVVRYGKGGEAGAAAVAEELGGLATEEDPAIPAGRARVFVGSDYAGPGSQNLRGTPLVGLDGAHRRQETGQPPITAGGVVCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T883</accession>
    <name>A0A7W7T883_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="6895" checksum="EDE26264015D2426" modified="2021-06-02" version="1">MNDLTQREWRKSSYSNGENGQCVELATVGAGLAIRDSTNSDGGEVLVGPRARLAFLAALKVSQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B0</accession>
    <name>A0A7W7T8B0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="30551" checksum="23F553623043433C" modified="2021-06-02" version="1">MRFGVRDVVGDRALVMAIVNRTRDSFYDRGATFADDAAMAAVDRVVAEGADIVDIGGVKAGSKGEVVDAAEETRRVVPFVAAVRERHPSLVISVDTWRHEVGRAVCEAGADLINDTWAGADPRLAEVAAEFGVGIVCSHTGGLPPRTDPHRVRYADVVASVVSELVDRAERMVALGVPRAGVLIDPTHDFGKNTWHGLELLRRLDELVDTGWPVLMALSNKDFVGETLGAEVDERVDGTLAATAVAALAGAKVFRAHQVRRTRHVVEMVAGIAGTRPPARVSRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D7</accession>
    <name>A0A7W7T8D7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="27690" checksum="EBA432A66D8A5C81" modified="2021-06-02" version="1">MADLPCGGPVPRQEPALPRRGGCLMIDTDTSGQRPSGRYPARGWASTVSSTSAATCSRCWRTVFRLSTLRGSVVSAAVVSRTVTVRVASPPGRRTPVVGCTAYPSPATPRSTRLIDYDRQRVCAWRACRTASAAQVRRRAVVCRAVVLRSRSGLRRGVRTVPVSGPGTTRNHWSSVVPSVRRGQGSANRHPRQNGTCPGADPISDPAMPPNPVTPVDHDFDPNASATSNPANTPFCSGATRRAKGFGLSAGHGSEVGAGRQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8F1</accession>
    <name>A0A7W7T8F1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16261" checksum="19E71A6EDA642870" modified="2021-06-02" version="1">MTPEEAIRELGLEPLPIEGGHWSQSWRSPEVSAIHYLLEAPEFSAVHRLDHVEIYTFHAGDPLRMLLLHPDGTVTTPVLGLDLAAGQRPQVVVPAGVWQASEPDGGWSLVGTVVVPPYTDDIVTFAHADEIAPAYPSHEGQVRRLCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J6</accession>
    <name>A0A7W7T8J6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Multiple sugar transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="416" mass="44970" checksum="6D6B898C3F7BC15A" modified="2021-06-02" version="1">MRGAYRRRPAVLGVVAVIAAAGLAGCGSDDGRITVNVYKYPQESFQKIVDRCNDQADGYEIVYHKLPREADGQREQLVRRLAAGDTGMDVLALDVTWTAELAEAGWIKEFTGADKTAVEDGTLETPLDTARYDGKLYGAPDNTNVQLLWYRSDLVPTPPETWDEMIEMGTKLKEQGKPGLIEAQGKQYEGLVVLYNTLVNSAGGRIVDDSGTKALVDDGAVKALEVLKKFATSPVVDPSFASSTEDVSRLAMEGGKAAFMLNWPYVYAAAQKKPDFAANFKWAPYPSIDGGPAKVTVGGINYAVSAFTEHSRESFDAVRCLRDAESQKFAAVNDGVPPTIESVYDDPDMAKPYPMRDAILDALKSSGSRPVTPAYQNVSTVISTILSPPADIDPKATGDRMRAELQDALDSKGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T931</accession>
    <name>A0A7W7T931_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6436" checksum="B2752E144E668327" modified="2021-06-02" version="1">MKAKINGTERELVDGATVAAVLALLGAPAAGVAVALDGEVVPRAAWPTTTVPEGGVVEVLTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T943</accession>
    <name>A0A7W7T943_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamate synthesis protein (Capsule biosynthesis protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="10"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="34470" checksum="03C8D60C2F74E943" modified="2021-06-02" version="1">MPAPVAPSFTVAAGGDILVHPALTEQADADGARDFAPLLEGLRSAVDADLSLCHLETPLSAPGEPTFGYPAFSAPPEIATALKGVGYDACSTASNHTLDRGVRGVVTTLDTLDRAGLAHTGSYRTEEESRTPLVLEANGVKVGHVSFTYGFNGIPLPEPWTADLLDPEAVLAAARAARAAGAEVVIASLHWGVEYSQEASPTQRSLAARLLAPDSPIDLIIGTHAHAVQPVERIGDKWVVYGMGNQIARHSEPRGITEEGIVTRFKFVKDGAKWRAVEAFYVPTLVELGPPIRVVDLTRAPVTARRAEASARTDGVVRSLGAAIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A5</accession>
    <name>A0A7W7T9A5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="22783" checksum="636D589E1CB463A3" modified="2021-06-02" version="1">MTGYPPPLPPGVYRRRRMLAGTAFALMLVGVTWLVGAMVGSEGPAVVPQGAQQSNPPSPADTPVAASSSSSSATSPPPPAPTPTLPPGPPPVCEDAQLGVTAKVGKPAYRSGEQPEFAIVVSNTGPLPCLREIGREVRELVVSTADGKVRLWSSNDCLATEGRESRVLAPGERFEFGARWAGSTSEPGCGKHTRLGPGDYLLTARVSGKSSDPVVFRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B5</accession>
    <name>A0A7W7T9B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretion/DNA translocation related TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028087">
        <property type="entry name" value="Tad_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13400">
        <property type="entry name" value="Tad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tad" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="11164" checksum="3684CCB3E9C28BB9" modified="2021-06-02" version="1">MRDDRGSVSLVAVGVAGVLVTVTALACQYGAALVERHRLEGVADLGALAAANGVILGASPCARAERVAHRMGGRVEDCSVDGEEVVVEIAGRSTVFGTPRARAAAGPVQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B8</accession>
    <name>A0A7W7T9B8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6021" checksum="3574D769B995D2D0" modified="2021-06-02" version="1">MSWRKSSRSASDAKCVEVAIGLRSTGVRDTKNRGGDALRFSSRAFGAFVAAVKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F6</accession>
    <name>A0A7W7T9F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="42672" checksum="7158D644C76888D6" modified="2021-06-02" version="1">MNDFDMTTSFAAVDIGRHRTDEKLLTVENLSVDFPTDDGTVHAVRDVSFTLGRGEVLGIVGESGSGKSVSSMAIMGLLPKTARIGGSIKFKDRELVGLDYKRMQPIRGNSVAMIFQDPMTSLNPVYTVGWQLSEAYRAHHDVSKKAAWAKAVEALELVGIPQPDRRAAQYPHEFSGGMRQRVMIAMSIINDPDVVIADEPTTALDVTVQAQILDTLLRIRDNTGSGIMIITHDLGVVAGMVDRVQVMYGGTVVEQGSVDEVFEAQRMPYTVGLLGSIPNPNMLGKRLTPISGAPPSLMNLPAGCAFSPRCPLAVDECRTTEPALLETDRRGHFARCHRSAHLATIPNPQRLFAHDEIGTVENPAALTMANPGLPVVEDLADAQRRYEEESPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA38</accession>
    <name>A0A7W7TA38_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="285"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="40526" checksum="63786B15CB6B5BC1" modified="2021-06-02" version="1">MITNALSSLWAEPRATDAPERVSRDWVLVGVLMVTALFEGVLRDDVAWRPFATIVAAGLAPVLLWRRTHPLTCVVVAFGTATALGLASLLSGVQSVGLDTMVYLLVFVYALVRWGSGREITIGLAIVAVAAVFGIVTDYTGPTELFGGLAVLAAAATGGAAFRYRAESRRRAVDQIRGQERVGLARELHDIVAHHVSAIVVQAQAGRAIAGRRPEAALETLAVIEGEAARTLAEMRAMVRVLRDGAPAEYASRPGVADLGALARRDPTPVVDVELPDDLGDLPLQVDTAVYRLAQEALTNALRHARNASRVEIRVVERAGRLRLRVTDDGQIDPGRSVDHGFGLLGMTERVQLLGGTLRAGPVPEGGWTVEAELPTKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA46</accession>
    <name>A0A7W7TA46_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019286">
        <property type="entry name" value="DUF2339_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38434">
        <property type="entry name" value="PTHR38434"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10101">
        <property type="entry name" value="DUF2339"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="708" mass="72398" checksum="C7B5CB6A24370F8B" modified="2021-06-02" version="1">MTGQDPLIRLAEELGTLGQRLAEVGAELRNVGAAARTSPAEQDATPTGESATPPDAVDLEGPAGEDSTLDGPGHDVRARNTPDHDAPTQDTSAQGDPTQGIPVQDIPVQDIPAQDIPAQGRPPVVGSPVPPQVHVPPQGTPVPHGQVAAQAVPGQGPPPPHAWPYTAWGPHQPVHTMPVPHPVARPSLFERLGQDGVGSRILAWVGGAVTLLGVVLLLVLAVQRDYLGPLPRVIAGAVLGLVLTGIGLRLHRSETTRTGAFALVATGVAVLYLDVVAATSIYDFLDTGGGLVAGLVVTALGLLLAMKWDSVTLAVYVVASCAVCAPILTSGFTVELVAFLLVLKIAAGPVHLRRNWPWLAVTAGVPPLLASVLALGGRPDDPLVLAGTGLVAFVVTLAGAVLTDRVRPGDNTALGLALGAPAPALLTTVLLERNEGAFVAGLVSVITLGVWVFGRRSAFRAGVGGVGVFALFLATALALDGSVLPAVVLGEALVLTVLTWRTNSRGPLIGATVFGAAGGLLATSDSIPPLLLLQEPLWTRTPGDLVAGIVTAFALGTLAVVLPWAATRLDVIERDQVVWSLMGLIVLYSAASAVLCAALLVSQDATGFLFGHTIVTVSWTIAALVLLVKGIDRRGLRVAGLVLVGAAVAKLVLFDMAALDGFARVLAFMGAGLVLLAAGTRYAKLVATRRIGANSPEGGAEATRGAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBF1</accession>
    <name>A0A7W7TBF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polar amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="69"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="276" mass="29803" checksum="75C7886584EB352A" modified="2021-06-02" version="1">MTSDVGRERLAYKRSRARRSTVVALLSTVAFAVVAWFAVTGSPGWPRVRQSFFNADVAWRALPGVLEGLWLNVRVLVVCGAIILVLALVVAALRTLPGPMWFPVRALATAYVDLFRGLPLIITLYLVGFGLPALRLTGIPNDYVVLGGIALILTYTAYVAEVFRAGIESVHPSQLAAARSLGLGRRKTLRLVVLPQAVRRVTPALLNDFVAMQKDCGLISVLGAVDAVRAAQIEQARSYNFTPYVVAGLLFVLLAVPSARLADAVTRRAATRQGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTC0</accession>
    <name>A0A7W7WTC0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein with HEPN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="6130" checksum="4D0F746EDBCB8589" modified="2021-06-02" version="1">MRRDPRVYLWDALNAADLLTRFSGGKTFEDYRPIRWSARRWNGNSRSSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI4</accession>
    <name>A0A7W7WTI4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="32639" checksum="2D729ACA25E4FB99" modified="2021-06-02" version="1">MRALLVVNPQATATTPAGRDVLAHALASDVKLDIVETAYRGHAADAAAGAVGDGYDLVVAHGGDGTVNEVVNGVLRGGTRPGLPMLGVVPGGSANVFAGALGLPRDPVEATYRLLQAIEHGTSRKVGLGRVASAGDDGGHDRWFTFNAGVGWDADVVAGVEAQRAKGREASPALYARTAFASYVAQRRRRQSLTVNIPGEPPIEGVRLAFVSNTDPWTYLGDKAIRLNPSTSFDGGLGLFALLGLGLPTIARYVAHLLATDGNPKGGNLLRRDDVEFVRVTCAEPVNLQVDGDLLGECTEVEFTSVPAALTVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTL1</accession>
    <name>A0A7W7WTL1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polar amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30166" checksum="3C91FEC14FD3C121" modified="2021-06-02" version="1">MTASTDVAPKQSGRTAAKIVPLRRPWRWASAALVSVAVLLLLWSVVTNDQFQWDVVAAYFTTEAVLRGLWLTLWLTAVTMVLGFAIGGVLAVMRLSGNPVLSSVAWGYIWLFRAVPLLVQLLFWFNIGMLYPALGGDAPLIGPLTAVILGLTLHEAAYAAEIVRGGILSVDRGQVEAALALGMGHGRILRRIVLPQAMRSIVPAAGNALIGTLKGTSIVSVLAVQDLLYSVQLIYNRNYLIIPLLLVATVWYVIVTSLLSIGQHYVERYYSRGAGRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL9</accession>
    <name>A0A7W7WUL9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17899" checksum="A4D1E0C7C638B792" modified="2021-06-02" version="1">MSVTDELLANNAAYAEQFSGPLPLPPAKHVAVVACMDARLDVYRILGLNEGEAHVIRNAGGVVTEDEIRSLAISQRLLGTREIILIHHTDCGMLTFTDDQFKRSIQDELGIKPSWAAEAFPDLDEDVRQSIKRIRDNPFVPVKDSVRGFVFDVATGKLNEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW5</accession>
    <name>A0A7W7WUW5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="12714" checksum="ABD5D7A5EC0959B4" modified="2021-06-02" version="1">MTSVGMIVDDEVAVTLRSGLGAAMLTIGDEVEILLTEAHVRSLCEQAVTVLGDLRAIELAGQAVDSAECAGARADLAATRAFAAAEAATRAVNDDLARQTREAARSASDAADRVRTTVAGTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX4</accession>
    <name>A0A7W7WUX4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="276" mass="29987" checksum="2FBDE41B16996836" modified="2021-06-02" version="1">MSQQHASAELTLGTTGVARRGVDAAESRVANRVWWDADADDYHAEHGDFLGAADFVWCPEGVREEDARLLGDVTGLRVLEIGCGSAPCARWLRREGAEPVGLDISAGMLRHARAAGAATGIDVPLVQASADQLPFAAGSFDAACSAFGAVPFVADVAEVFREVRRVLRPDAPWVFAVNHPMRWIFPDDPGPAGLTVTHSYFDRTPYVEVDGTGRATYVEHHRTLGDYVRALVGAGFLVEDVVEPEWPAGHERNWGQWSPLRGKLFPGTAIFRTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX8</accession>
    <name>A0A7W7WUX8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="261"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="36715" checksum="112CCDDC5D20268E" modified="2021-06-02" version="1">MPTRSDAWLAAALVVLSAVASLLVDSGTAYRPPDALGFGFAVASATSLLWRQVAPLAVVAVADALVVASTASGYAVTVVQWPAWIALFTCFTVSTWWVRVTASVLTVAAVGGYAALDRGTVGPSELFSVVMVLLVSAAAGEAVRGRRAYAAAEQARAASESTMRERARLARELHDSLGHAVNVMVMQAGVGRRVFADNPEFAREALGNIENVGRDALGELDGLVRVLQDAPPPDFSVLVDRVRMTGRDLRVNTDEVTLSPDTGRALHRIAQEALTNALRHTSTGRIDIDLARVGDDVVLEVVNEGRNLTAGPGRGLANMRERAVLVGGTVEAGPVEGGFRVRATLPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV10</accession>
    <name>A0A7W7WV10_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="43344" checksum="713D9056212715ED" modified="2021-06-02" version="1">MADFRLPDLGEGLTEGEIVAWLVSVGDTVAVDQPVVEVETAKAVVEVPCPYAGVVTARNGEAGEKLAVGSVLLTVDGTAAAEVPESSEYSGNVLIGYGTSDTRRRRGPRRSAVPDAREPGAVGGPGGPGTARATREVDRSRATGVTQGARADQGPGVISPIVRRMARERGVPLERITGTGPGGVIRRADVESASTPKGRRIPLTGLRGAVARKLATSRREIPEATVWVDVDATGLLAARAALPGVSLLALLARFTILGLRRYPELNSRVEGDGIVVLDGIHLGFAAQTERGLVVPVVHDAHTLTTGALAEAITGLAASAREGTLAPAVLTGGTFTLNNYGVFGVDGSAAIINHPEAAILGLGRVIDRPWAVDGRLEVRKVAQLTLAFDHRVCDGGTAGGFLRYVADCVEAPIKALRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV29</accession>
    <name>A0A7W7WV29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="35727" checksum="DBD451460C2439A5" modified="2021-06-02" version="1">MTSAGVATTFLVLLGLALLIGPWILGTANRLDRLHVRTDAAWAALDAALARRAVVTRAVGAVRGVPELATAASRAERAPRAEREAAENELAVTLSDLDRTTLAPALAAELLDAEQRVVLARRVHNDAVRDTLALRRRRPVRWLRLAGTAPTPSYFEIAEPVADGEVTALTPRTSARLLLLDEQGRVLLFEGADPARPDELFWFTAGGGVEPGEDLRAAAVREAHEETGLHLSPEDLIGPIWKRHAVFSYDNLGYTAVEWFFVAHVPPDTRIDTSGFETLEHETIRGHRWWSTADLGATKDTVYPVQLADHLDDAAEPWDGTTRQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV98</accession>
    <name>A0A7W7WV98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA reductase-like NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="15"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="481" mass="50872" checksum="7B94A9C6023122FE" modified="2021-06-02" version="1">MPSRPAARNLIDGKWVDRNPRDSLAPATGEVLGVFADGGAAEADAAIAAARTAFTTTSWARDRDLRARALLELADRLQARRDEFVTLLARENGKILAEAAFEVDMAVPKLRYAAALALTDTGRSAEVKPDLYSLTVRQPAGVAGVIVPWNAPVVLAVRSFAPALAAGCTVAMKMPAQTALVNGLLYEVIAATESLPPGVLNAFTESGNEGAPLLVSDPRVDVVSYTGSTTVGREIMTAAARTLKPLSLELGGKTPMIVFDDADLDRVVPALTKAVTTFTGQFCMAGSRVLAQRGIADRLRAALVESLGSVRVGPGDDPASEMGPMVDVAAARRVDGIVADAESYATVLVRGGIPTEPELAGGAFFRPSLVEVGDTAASIVQREVFGPVATFEVFDDEADAIARANATEYGLAASVWTTDVDRPLRVGRDLDVGTVWTNTWAVVHDQFEEGGFKQSGLGRLNGARGLEEFQEVKHFVHPVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI5</accession>
    <name>A0A7W7WVI5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="9" type="ORF">F4559_001937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="42957" checksum="3BA14F9A16B6D90C" modified="2021-06-02" version="1">MSDELGLFTDPDDDKPGGRSARRKPKRRRKTVLWVVVALIVAVGGVGAYYGYQTLSGIGSYEDYAGQGETDVVVEVRDGDLVSSIATTLKEQGVVASARAFTEAGENDARVTAIQPGFYLMKTRMSGEAAVTRMVDPKTKVVPLEVKGGNVLHDITGVDGKVVKGIFSMLSDASCVEMGGEKKCVTPQELRDAAENAEPAALGVPDWATVDFLAAPKPNRLEGLIVPGLYSLKPGAPAVELLKSVIETSVTRMQGYGIPAGTKETGFKPYEVLVIASLVEKEGLEKDFGKISRVIYNRLKVGQILQFDSTVNYKLDRPVVTTSDEDREASGPYNTYVTAGLTPTPIGSPSRAAIQAATNPEAGTWLYFVKCNKDGTTCFSNTYDEHRQIAEKAQREGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR2</accession>
    <name>A0A7W7WVR2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26869" checksum="C85FD74EB0F580D0" modified="2021-06-02" version="1">MHWYEDDGLWVGFADVMFPARRVAEAARLVAESPLLRTDPGARVLDLACGPGFHVVPLARAGADVTGVDLSTAMLDRAAKACAEAGVTARLVRADMLHHVEPDTYDLVVNMYTSFGYFTDPGDNLAVLRNAHDSLVPGGKLVLDMMGKEIFAGWVGRPQAVDVEGGTAFLRDTVLDDWTRVRTDWTLVRGDEVRRASIVSALYSAAELRALFETAGFGEVEVYGDFDLSPYDNHARRLIVRGTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV0</accession>
    <name>A0A7W7WVV0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation:H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="48"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="239"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="442" mass="46042" checksum="EC5E10B1C831423C" modified="2021-06-02" version="1">MVDESGAGKGVAGRLTAAGLGTVPGTVLGAGEYLGFLHAGLPPALAALVYGVAIVCAAFLLSWAAEAAQVDVSAGLAIALLAIVAVLPEYAVDLVFTFEAGQEFADQGRCAAQGATDPCSLALANMTGANRVLVGIGWPLVVLVATIATVRKHRSSESTAPGRVRLAPTMSAEVAFLGVATLYSLTLPLRTSLTLVDAVVFVAVFAGYVWRLSKAPVESPDLLGVSAWLGGLDARRRWVVGLFAVAGLVVLACAEHFAQSLVESGQQLGVDEFLLVQWVAPLASEAPELIVACLYAIRLKASHSLGTLLSSKVNQWTLLVGTIPVVFALSSGSLSGLPIDGHQRLELLLTGAQSLFAVAILMDLGLTVVGASVLFALFAVQFTASVTLSAETNRVVTLVLSGLYLVLAVVQFVRHHRDTTRTVRDGFRTPFKELSDHPGDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX9</accession>
    <name>A0A7W7WVX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23139" checksum="CB341EB5761A8873" modified="2021-06-02" version="1">MGDPVIRVLVADDHAAIRTGLVMILGGAADVEVVGEAADGERAVRLANALRPDVVLMDIRMPGVDGIEATRRLAGVCEVLVLTTFDVDEYVHGALRAGAAGFLLKSVEAPALVEAVRRVAAGDGVLAPSVTRRVMREFAATAPRSRPVALDALTDREVDVLKCLGAGLSNHQIGRRLHIGETTVKTHVSRVLAKLDLRSRVQAAILAQDAGLLTDGPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY5</accession>
    <name>A0A7W7WVY5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Zn-binding protein involved in type VI secretion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008727">
        <property type="entry name" value="PAAR_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05488">
        <property type="entry name" value="PAAR_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="10561" checksum="991D36A3BA834A6B" modified="2021-06-02" version="1">MPKAARVGDKTSHDGTLAVPSQAALAMKIATVLIEGRPAAVMGCVHVCTQGPHIRLATANVLLPRPGPPPTVFVGGAPAAVVGDRSVCQATIRFGATTVEIGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW92</accession>
    <name>A0A7W7WW92_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045590">
        <property type="entry name" value="DUF6463"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20064">
        <property type="entry name" value="DUF6463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="15843" checksum="87FB987131DDCC60" modified="2021-06-02" version="1">MGPQRWAAGIMVVLGAGHLGLSIVLKWSVVVGWVARGGWAAVPLIPADRSEAALVNGLTFWAGPGSFAVPLLLLGCLTWHLAGRGVTLPVGIGWGLAVWCLVGGVLLVPSPYFLGVVAGVLLVVARGRAVTGIASGRPGPVQDVGGVDGGDRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWD2</accession>
    <name>A0A7W7WWD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="370" mass="37207" checksum="99D85E8C76313394" modified="2021-06-02" version="1">MDRRRFRQGGREWLVLWWVFFVNGAVLSSWAPRIPAVAASLDLSDRGLGIALFGIAAGSVPALLVTGRLIRRRRATTLCLSGFAFAAGLPLIAAADSLVTLTVVLVLLGAAGGTLDIAMNTAAVRWERTIAPRRVLSRLHGGYSTGVLVGAGGATLAADVPVGLHFTVVAGVLVVVLAVVVPRLPAETPADAPTRTRRAARPAVLVLAVGALFLEGVVTDWSALLAARDLGAGPTAGAAVVTTFTVAMALSRTLTAGTRTAAVAGVLLAVVAVPAALVLAHPAVFLAAAACVGAGLGPLFPAAVGASGDIATVTAVGYCAYLAGPPVLGAAAEAVGLPVAFGVAVSVVGVVVAMAARRCLPRRHSGERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK2</accession>
    <name>A0A7W7WWK2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16359" checksum="3DB7210AC4947B3C" modified="2021-06-02" version="1">MKLPVSTEWLLHCATTLAQLEPGATASAARLAEYYDLPAAALAKQLQALVRAGVLAATTGPRGGFRLGRRPEDVTLLDIVEAVGGAASPYECREIRQQGKGALPPETCRDACVLAVKMHEAHQAWRTSLAATTLADVLTSLPEWAVGRTRSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX75</accession>
    <name>A0A7W7WX75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="29" mass="3291" checksum="21D3FFB5BAA4DE3A" modified="2021-06-02" version="1">MCAGLEQGSVYHPRSDRVDARVLGMWIGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC0</accession>
    <name>A0A7W7WXC0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="34163" checksum="153EB665F5B789DC" modified="2021-06-02" version="1">MTRIVRADHGITVGTPPPHPERTALLEARGAVLTWDVLTGEPSLVVHDPVAADWLWEVVGLDAADAILGAAAEVDLVPGPLHERARTAAHLDWVGAWWPASPTAGIAGVNPALLRAERAVAVNAVEHLLDDEDATGRALRGIPPLDTAGCRLSVDDLARQVLALAEDYGVEQAAAVPTRADFALAAGGDPSTGVTVLSGVSETDWSTVPRGLLDATAPARWSVVREGGTSYLEVAVPSGPTPGPVPLARFGPVEVPLERGALGWYTGRAAVAPTVLLLPPDRRVLSVSVPGYTAAPEDSGRRAAIVAYARARMVLPSATLTEREAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE3</accession>
    <name>A0A7W7WXE3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030663106" evidence="2">
        <location>
            <begin position="19"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="37607" checksum="57DFA019B5C50D45" modified="2021-06-02" version="1">MAHLPPAFGSLRRSAARAAVVVACALAVAEVIRLLLTDLSPHRVAMAAAVVPATALQLHRFTPSSAKPRFAAFGVLVVLVFAPVLSAREPWIALPGFVAAAALGVFAVVPGLVIATATVVASGATHLGGGPNAVVSGVVATTLAALVLYGPTWLATAADPDSARSAVAAERRRVARDLHDLLGSGLSAITVQGELANRLLPEDPLRAKECVTEVVDIARHALGDVRSLALEFRTPSVPEVFASARALLTAAQVAVRLDVDDREVPEPAATVVAKLVREGVTNVVRHSRATRCEIALRRDGRGLELDIVNDGAPACAGMPGSGVRNMTERVREIGGVLTVERLDGDLFRLRARVPLGASGGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE6</accession>
    <name>A0A7W7WXE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.28" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04316">
        <property type="entry name" value="dhbA_paeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25463" checksum="45449F591C3268DF" modified="2021-06-02" version="1">MADHGIAGRVALVTGAGRGIGAAVADALADEGVKVVGLDVLDGDLVVDVSDVDAVEDAVAHVEGSVGPIDILVNVAGVLRTGRILDVTDDDWRTTFAVNTDGVFHVSRAVARRMAPRRRGAIVTVGSNASGVPRTDMGAYAASKAATTMFTRCLGLELAEFGVRCNVVSPGSTDTDMQRALWTDDEGPRRVIAGDPSTYRVGIPLRRIADPADVADAVLFLASDRARHITMQNLFVDGGATLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXI0</accession>
    <name>A0A7W7WXI0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="39356" checksum="33E69C797B12661A" modified="2021-06-02" version="1">MTEPSARPTVDVVIPCYNYARFLRACVNSVLDQPGVDVRVLIIDDTSTDDTPEVMAELTRDPRVEGRRHEVNQGHIATYNEGLLEWCKADYSVLLSADDLLAPGALARAVAVFEANPNVGMVYGRVVYYQDHDDLPSIVTPPAGVTVWSGVDWIRERCRTGQNVLSSPEAVVRTSVQQRVGGYRPDLPHAGDLEMWMRIAAVSDIGYVRGKPAAYYRVHQQSMFRTQFSSVFADLEQRQAVFDRFFAEHPDLPPILKALANRSIAKDALWRAVRAYDRDKVDEIPVDELVEFAKSVYGGTTRLPEYRALHRRRMLGARLCSRTQVFVGSHLVKRGRGLVGKQVWKWRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ2</accession>
    <name>A0A7W7WXQ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7181" checksum="80BC6303C3F5E565" modified="2021-06-02" version="1">MRNTVFRKLMANEFGQVRAELMASDHVLSALGGRTPDQALDEGIPAKEIWVAVCDAFEVPEHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW7</accession>
    <name>A0A7W7WXW7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="169"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="732" mass="80119" checksum="3CFC8B68FF0D87DF" modified="2021-06-02" version="1">MSMLYGRLDDLREQSSRRLASALRQTGGTHQMRSERDTSVALYSDQLAQYSAVENGLCFGRLDFDDEGRFYIGRIGLFDEDREYEPLLMDWRAPAARPFYLATAAAPEGVKRRRHLRTRQRKVVGFDDEVLDITSVDPARRSEGLTGEATLLAAVNAARTGQMGDIVATIQAEQDRIIRTELNGVVVVQGGPGTGKTAVALHRAAYLLYTHRRQLAKRGVLVVGPNTTFLRYIGQVLPSLGETGVLLSTVGELFTGLVATGREAAGTAALKGRVQMADVVANAIRDRQEAPALVEIPFEQDTLKLNRQAITAARGRARRTRRPHNEARRTFVREIISTLANQAVSRLGRHLLDQADIDDIRRELREDENVRAAVERLWPTLTPQRLLEELYASPKRIARAASKLSPAERALLVRTPGAEWTPADVPLLDEAAELLGEDDTETKARAERRRRQAIDYAQGVLDILDLEDDADPDILMATDLVDAYRLAERHGAETYETAAERAAADRTWTFGHVIVDEAQELSAMAWRTLMRRCPSKSMTVVGDIAQTGDIAGASSWSEVLSPYVMERWKLTELTVNYRTPSEIMAVAADVLASVDPALVPPTSVRDSGFEPWARRVTSVEEALPGLVEREIPAVGDGKLAVIAPAASVPSVRTLVPDAADDLDAQVVVLGVTDAKGLEFDSVLVVDPAGILAESPRGASDLYVALTRATQRLGVVHTGELPEVLSGLREVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY34</accession>
    <name>A0A7W7WY34_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="23497" checksum="AE846AC8ABF02100" modified="2021-06-02" version="1">MRVILAEDSTLLREGLVRLLAEEDHEVVAAVGDADALLDAVAALRPDVVVTDVRMPPTNSDEGVKAALEIRRRFPDTGVLVLSQYVERRYAVDLLTDHTDGVGYLLKDRVVQVEEFLDALRRVGTGGVAFDPEVVRRLLARTSHPLDVLSPREREVLAHMAEGHTNYSIAARLHVSRSAVEKHIASIFDKLGLTAEDGYSRRVLAVLRYLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN5</accession>
    <name>A0A7W7WYN5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (TIGR02680 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013496">
        <property type="entry name" value="CHP02680"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02680">
        <property type="entry name" value="TIGR02680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1353" mass="147238" checksum="74075D264368CB39" modified="2021-06-02" version="1">MTVTGLPRAESGATPEAVARWVPERAGILNVWRYYDEVFRFHKGRLLLRGPNGTGKSKALELLLPFLFDANLRANRLSTFGTSERTMHWNLMGEGATGTTRVGYVWLEFRFPGVDGSPDRWFSCGARLAATRHTTAVHPDYFTTGQRIGVPGGLDLTDPNNAPLTSKALEAALGDLGALHQNAADYRAAVRSTLFPGLSEQRYDALITALLQLRTPKLSQRLDPGLLSALLSKALPPLGEAEISDLAEGFERLDRQREQLKRLDAEVEVAQHLKTRQRAYAQRVLRAAAAKLISATTELGNLADAAKLSEDEHRRAVRHKEEAEERGELLEHRIVETDGRIQGLTGSEAYRKGEQLDRLRTRVREARATAGKRRTDAARHRQVARTDAEAADTAARHAQARAAAAGALADGASTAAARVGLASVHAEIARVLAEPSRARALLRAAVQARAEQVEAVRAALNEHEVAVNSRQDAERALDEAREALAEATERRAESAVRRESALAELRAAVLVWAAGCRELTFADPEALADLAASETAMLTKIDSAASRVLNTITREETLVGTALAAAERDRDALRDEVRLLLTEEDLPPQPPHTRTADRQAMTGAPLWRLVRFTDAVPDDVRASVEAALQASGLLDAWVGHDGAVVGHDTFAEPGAVPPAPGRSLADVLVPEVDPPVAADVVARLLGGVAYGEDLPEVHPVAIGADGGWRIGNLRGTWRKDETSHIGALARQRARQRRLTGLRERIAVQEGLIGTHTAALRSLAERRSDVEADRHARPDHTGANAALEALTRADSLVYSADGVVRRSLDGLAKSEQRVDRALRALTTTAAEHGLPAEREALTAVVAAVAAFRTASDAWIDEHTALLAARREADRTAEQAQRSRHVAEQREDEADDAEAVGRGLDSELDAVEGAIGFDYRQVLDELAVLRERLDSTRREASANQKEIGTLAQRLGELTNRRATDARDRDRATEVRDQAAVRFRHLADGSLPADSGLDDLSAFGRVLTASSGVRAALDAARSVAAAWPALAHSPKNLGDAAHRLAEEVHASREILGGRADLELDSDEDVQIFSAMVDGVRIGASALSDLLRSDAERSRQDITAQERELFDRTLTGDTRRHLAARIRQAHDLVDGMNARLERVRTASKVAVRLVWEVSPELPPGTKAARDLLLKDPVRLTEEDRESLHRFFRDRVGQAKGDETATNWEQQLGQVFDYTAWHRFVVKVDRMNGTGWQPLTKKLHGALSGGEKAIALHLPLFAAVAAHYQAVTGAPRVILLDEVFVGVDTVNRGQVFELLSALDLDLVLTSDHEWCTYRELDGIAIHQLISGGDDDAVTTARFVWNGAEVVDEEVGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYP0</accession>
    <name>A0A7W7WYP0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8299" checksum="8CCBF9FF13F64C60" modified="2021-06-02" version="1">MTEQSEKALTLTLELEPRIAFALTTVARLDQVEIAEALQRLISVGFEVYAAEKLDGLAVAIQNRSWLEPIFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYP3</accession>
    <name>A0A7W7WYP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6999" checksum="02B28CC53AD881A5" modified="2021-06-02" version="1">MGIKWMDSKVVKSARALAGRIPEQGAKDECMVCGKPIRRHRTVTGEGRVCSLTCAQYWAENMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV5</accession>
    <name>A0A7W7WYV5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30995" checksum="B1A50A177EFC1323" modified="2021-06-02" version="1">MTGVWRRRLDWIAVHSLGLALGLMFALPVLFVILTAVMSDSQAFTAQLWPREWHWENFVEVFDKAPLLKYLVNSLTYALLATAGMLLSSIPAAYALAKLRWRGRNAVFLLVVGAMMLPPQVVAVPLYDTWSSLGLTGTLVPLIVPYFLFDAFSIFLLRQFFLTIPQSYVDAARVDGCTEFQTLTRIVVPMAKPGIAATALFCFLYTWNDYFGPLLYTGEKPDQWTLSLALSSFKGMHHVQWNLTMAVTLLIMVPAVVLFVLAQRSFVKGITFTGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ54</accession>
    <name>A0A7W7WZ54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="121"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="468" mass="49193" checksum="BDBDE78061DBA7B9" modified="2021-06-02" version="1">MTTGDLLHPGARLVDAAGGGVLDGAALRAAVDAVVFDDVPAGVLFARTAVDVPSVLRYLAAFESGRAVALLDAGQDRDVLLELVARFRPAAVLGAEGDAPEGYREGDVGGSAWVRESADGVVPHPDLAVLLPTSGSTGNPKFVRLSKAAVLANAEAIADVLGIDADEVAPTSLPLHYSYGMSVLNSHLLRGATVVVEPTGVMGRPFWQAVDEYKITSLAGVPYHYEMLKRLRFDPAKYPSLRTITQAGGKLRDDLVVEFNDKMRAADGKMFVMYGQTEAAPRMTTVPADRLADKIGSAGPALPGGAFAIRLEDGSETTAPDVVGEVLYRGPNVMMGYAESEAELALGDVVGGVLETGDLGRLDAEGYLFITGRLKRIGKVFGNRVNLDDLEQLLRVAGLDLGAAAAVPAGDKVVVWVENATADARKAAAKALSEKLHLHVSGFDVREIDSLPLLASGKVDYRALEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ91</accession>
    <name>A0A7W7WZ91_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XTP/dITP diphosphohydrolase</fullName>
            <ecNumber evidence="2">3.6.1.66</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="31563" checksum="E4F3840FBBB471EC" modified="2021-06-02" version="1">MTHLVVLVSAHDTVLPAAALPALRGAAAVYAEGVPWGDPPPEAVPAGPVVLVTTSPTSPFAAALVAAGAEVVRNPAGTALLSAVSVMDRLRSPGGCPWDAEQDHKTLRQYLVEETYELLEAIEDGDRAALREELGDVLLQVLFHARVAAEHGEPFGIDEVAGDLVAKLVGRHPHVFAGGDPAVRDARSQEHRWEELKQAEKRRTSSVDGVALGQPAVALAGKLAQRTGRAGLPADLLPTGEDAGSALFAVAARAKLAGEDPETELRAVARAFEAKVRAAEKSARAAGVTTMGVADWRAHWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZD4</accession>
    <name>A0A7W7WZD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021218">
        <property type="entry name" value="DUF2784"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10861">
        <property type="entry name" value="DUF2784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13153" checksum="2B6F6FB2D8A5FCCA" modified="2021-06-02" version="1">MVTRSLAELVMVLHFAVLLFLVVGGYLAWRLPKVLYAHVAMAAWAVLIVAFPVSCPLTSLENTLRVASGAEPLARGGFIDTYIDGVLYPESAAPLVQVLVGLAVLTSWVGWFARRAAPARACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZI1</accession>
    <name>A0A7W7WZI1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc/manganese transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030810248" evidence="4">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="31863" checksum="F8A7546E50561D45" modified="2021-06-02" version="1">MTVRNALLGVVTALTALTLTACGTAATGPAEGGRIKAVSSTNVWGSVVAAVGGDAVDVTSIISDPSGDPHSYEARPADVAAVRDADLVIFNGGGYDDFFATLIGPGSESARKIETFPLSGKASGHDEPPAEAGHDHEVNEHVWYDLETVRKVADQVAADLSAIKPGNKASFESNAADFTRRIEELKTKVEGIGRGKRVLETEPVSHYLLDLAGTESATPAEFVEAVENESDIPAAALAQVLDLVGKKEVAAVVHNTQTGNAAITQLVGKAAEVGVPVVEVTETLPVAAAGYLDWMTKQVDALAAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXK7</accession>
    <name>A0A7W7SXK7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase subunit L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="147"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="644" mass="68856" checksum="E8B2607EEFBF0131" modified="2021-06-02" version="1">MTEPVAASGIGGLAWLLLALPAFGAAVLLLGGKRTDKWGHLLGTATVVGAFAYGLVLFFDTLGLDPEKRTSELHLFDWVPVEALDVEFGLRLDPLSLTFVLLITGVGSLIHVYSIGYMAHEAGRRRFFAYLNLFVAAMLLLVLGNGFVTLYFGWEGVGLASYLLIGWYQYKPEAASAAKKAFLMNRVGDLGLAIAIFILFKELGTTQYTEVFARVGELSAAEVTAVTLLLLLGACGKSGQFPLQAWLPDAMAGPTPVSALIHAATMVTAGVYLIARSNPLYNLSADGRLVVMCIGGFTLLIGCLIGCAYDDFKKVLAYSTVSQIGYMILAVGLGPVGYALGIMHLLTHGFFKAGLFLGAGSVMHGMNDEGDIRRMGGLARKMPITFVTWTLGYLALIGFPFLSGYFSKDAIIAAAFSEHGWRGWVFGGVAALGAAITAFYMTRLLILVFLGKARWTDLKSADGRDYHPHESPASMTVPMIVLAFGSVAAGFLFSTGDNLAGWLEPSLGALQEQHGVLDHTAVNFLVLGLSALGVVVAWLVFGRRPQPVQRPLRVSFPVRAARADLYGNALNEVLFARPGTWLTRALVFVDNKGVDGLVNGTAALLGGSSGRLRRLQTGFVRSYALSMLLGTIFVLGALLAVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXR8</accession>
    <name>A0A7W7SXR8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="16781" checksum="3CC2A6DD418AF497" modified="2021-06-02" version="1">MTTAPRTRGVIALLEANCTVCMICARECPDWCIHIDSHTETEQQSGTARPRARNVLDRFAIDYGQCLYCGICVEACPFDALHWAPDFSYPGTGTTDGDGAVAELVHERDVLATWVAHVPPPPPLDPAAEPAPETATGRPGRPGTGTTRPAGALRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXU7</accession>
    <name>A0A7W7SXU7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">F4559_000293</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="265"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="381"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4962934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="453" mass="46852" checksum="00561AD4EE02E1B6" modified="2021-06-02" version="1">MITEAQATMARLFGTDGVRGRANTTLTPELALSLASAAARVLAEHDRSHRPVAVVGRDPRASGEMLEAAVVAGLAAAGADVLRVGVLPTPAVAFLVADLGADVGVMISASHNPMPDNGIKLFAAGGHKLPDAVEDEIEQRMADADAHRPTGADVGRVRDIADAERRYVDHLLSVTPHRLDGIKVVVDCANGAASVAAPDLYRRAGAEVVEIHAAPDGLNINEGCGSTHLDQVRAAVLEHGADLGIAHDGDADRCLAVDAAGVEIDGDQIMAVIALAMRDAGELTDDTLVATVMSNLGLHLAMREHGITLRTTAVGDRYVLEELRAGGYALGGEQSGHVVLPAHATTGDGLLTALRLMARMAQTGRSLADLAGVMKRLPQVLVNVVVADKAAVAEAVSVNDAVAAVTAELGDEGRVLLRPSGTEQLVRVMVEASTHEIAETAARRLAGVVSSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY31</accession>
    <name>A0A7W7SY31_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Basic membrane protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030815884" evidence="3">
        <location>
            <begin position="26"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="79"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="383" mass="39057" checksum="681FEF4E06754FDC" modified="2021-06-02" version="1">MRRPIRGLAVAAIALTSIVSMAACAKDSGGTSGGSSTTSASGGCKFAEKPPAAAAATSSGTAAGEKVDGKALKVGLAYDIGGRGDASFNDSAAAGLDKAKADFGITDVKELTAAPNEAEDAKQTRLRQLASEGYNPIVGVGFAYAESLKVVAPQFPNVKFAIVDGAVEGAANVTPLTFAEEQGSFLAGVIAAYQSKNCHVGFIGGVKIPLIQKFDAGFEQGAKKAAPDIKIEKKYLTPAGDFTGFQDPTKGQEAAKGQIEAGSDVLYHAAGASGKGVFSAAKTANVKAIGVDSDQYNQATVAESKDVIVSSMLKRVDVAVYDFVKAVAKNDLASLPKVFDLKVDGVGYATSGGKIDNDLKAVLEGYKAQIISGQIVVSDKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY91</accession>
    <name>A0A7W7SY91_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="11">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_000457</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="10">
        <location>
            <begin position="579"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="711" mass="77005" checksum="3C86787DC142404A" modified="2021-06-02" version="1">MIPDFADIDLGEPEVGPADERPSGAWETPEGIDVKPFYTAADLEGLDFLGTYPGIAPFLRGPYPTMYVNQPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVAGDVGMAGVAIDSILDMRQLFEGIPLDRMSVSMTMNGAVLPVLALYVVAAEEQGVAPELLAGTIQNDILKEFMVRNTYIYPPGPSMRIISDIFAFTSRRMPKFNSISISGYHMQEAGATADLELAYTLADGVEYLRAGRDAGLDIDAFAPRLSFFWAIGMNFFMEVAKMRAARLLWAKLVRQFGPRSPKSLSLRTHCQTSGWSLTAQDVFNNVPRTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLLLQQESGTTRVIDPWGGSAFVERLTHDLAHRAWAHITEVEAAGGMAKAIDAGIPKLRIEEAAARTQARIDSGRQPVIGVNKYRVAVDERIEVLKVDNAGVRARQLAKLDRLRAERSQDEVDRALDAVTRAASSDANLLEAAIDAARAKATVGEISEALGRVWGRHSAQIRTITGVYREEVGSVSTVDATRELVDRFAHEEGRRPRILVAKMGQDGHDRGQKVIATAFADLGFDVDVGPLFQTPDEVARQAVEADVHIVGVSSLAAGHLTLVPALRAALAEQGRADIMIVVGGVIPPQDFDALREAGAAAIFPPGTVISEAASDLVRDLSARLGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG7</accession>
    <name>A0A7W7SYG7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="5" type="ORF">F4559_000636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="50"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="37029" checksum="A6C03BA1771AD34E" modified="2021-06-02" version="1">MSVVVGRTPLAGWREGDPEGRRQWVSGSLPGLPLRIAYETWGTLNASRSNAVLVLHALTGDSHVAGVVEPGHPTPGWWDGLIGPGRALDPSRWFVVAPNVLGGCQGTTGPGSSAPDGQVWGSRFPRVSVRDQVAAEVLVADALGISSWAAVLGGSMGGMRALEWAVSYPDRVRSLLVLAAPAASSAEQIALASAQLHAIRLDPVVGLGIARRIAHISYRSYAELDARFGREVQADGRYSVESYLDHHASKLINRFSPESYVVLTEAMNGHDVGRDRGGVREALSRITARTIVAGIDSDRLYPLSQQEELADGIPSVDKVEVVTSPYGHDAFLLETDQVTPLVHTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYN1</accession>
    <name>A0A7W7SYN1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="51"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27020" checksum="EB566A3508132052" modified="2021-06-02" version="1">MSVDLARHVPPALRSGIRRVASRAGLAISRHPFPRRVVRLANLVGVTTILDIGANSGQYAALMRESGFPGGLVSVEPLSGPFGDLRRRSRDDRSWSALRVAVGDREGEVEINIAGNAGASSSVLDMLPVHEQAAPDSRYQGKEVVRMTTLDALSADLRLPLRHTLVKIDVPGYEAQVLAGAAESLSSITAVQVELTLVELYAGQRLMDDVVETLTDRGFTLWALEPGFSDPRTGRLLQCDGLFVREESIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV4</accession>
    <name>A0A7W7SYV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40158" checksum="013C3D1A5FD1ED66" modified="2021-06-02" version="1">MIGAAPTMSDSEVHGTVAHGFEAVRDEFAAVAQDAQLAVHLHGRRVVDLWTGDVAGDSLTGVYSSTKGATALVVAVLVQDGVLELDLPVAHYWPRFAAAGKGRITLRDVLTHRSGLIGGLSADELADDRETARRLADRRPYWRPGTAYGYGGFVTFAIVGEVVRLATGRSLQEHYEERIRAPYGLDLYLGLPEALEERYLDVLPGSASPAELTAFLATLPSPYSIVGMGYGFGLDQVAFLNTRRVRALGQASAGGVGNARGLAAMYAAATFGPLLGPETLGEFTTLHSTGRDLVTGTGQYALGFQAKGLRYPFLGADAFGHNGSAGSEAFADPLSGIAFGYVRRRFSVDWSYPEHDRLVAAVHRAAVGAVDDNGKVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ3</accession>
    <name>A0A7W7SYZ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="3">
        <location>
            <begin position="95"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1029" mass="110838" checksum="F165D4556ED869B3" modified="2021-06-02" version="1">MQVRVLGPFEVRTADGVLVDMPGARLRGLSAALALEAGRVVPKAALVDWIWGDSPPADAANALQRLVSRLRKVLPEGIVEGNTDGYRLRIAVDDVDALLFERLVRRADGRREALALWRGTAMQDVGLQDSEAFDAAVTRLEGLRLTALEDLYDAESTPESITELTDLVAAHPVRERLVGALMRALVASGRDTEALVVYQRTRETLADTLGVDPSPELSALHVALLRGELGHREESRKTNLRAELTSFVGKEADVAAVRALVGEHRLTTIIGPGGSGKTRLAVETARTLLGELPDGAWLVELAAVGPDGVVQATLTGLGLRDTLLGGGSGADLTDRLIAAIRERGALLVLDNCEHVIESAAAFAHRVLGECRRLRVLATSREPLGITGEALWPVEPLALPGPDADAATIAASPAVRLLRDRAGAVRPDFTADAATMARVCRALDGMPLAIELAAARLRTMSVDQLAARLDDRFRLLTGGSRTALPRHRTLRAVVDWSWELLTDAERAVLRRLAVFSGGAGLEAAERVCAGDGVDRWQVLELLTSLAEKSLLRNDDDGTPRYRMLGTIKEYAGHRLVEAGEADATRRAHLDHFTALAETAEPHLRRAEQVEWLAVLHADHDNIRAAIRGAVTAGDAHAAMRLAAGAGWYWWLGGHKAEGLESITAATGLSGEVPDDIRATVYALVVHFLNSGRGDEHLAAKWIHEAYRYSRDVPRGRHPALRFIEALERLVRTPDAALVAFEPLLDDEDPWVRALARLHLGKMRVVLGQGGPDVDAYLETALAEFRALGERFGTGFALTELADRTATRGGFARACELYDQAIAVVTEVGAAEDVIRMRSRQAQLHRLLGDEDAAAAALAEAQRCADRVTWPDALAELAFVKAELAHWDGDAREARHQLGVAKSLLADLADGPHYRVVTHDLLGYLADDPEEARAHRTQACRAAAEAGHAPVIARVVVGVADLALRDGRYEQAARLLGASDAVRGLSDRSDPDATRIGQAVRDGLGEPLFAEAVEAGARADWHDLVAVTLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT9</accession>
    <name>A0A7W7SZT9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ORF">F4559_001347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="592"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="779" mass="83293" checksum="BC44D51E568D7EC3" modified="2021-06-02" version="1">MSETSALPVLPLDDVVVLPGMVVPVRLSGPDATAEARAAVEAATAGDVNRVVLVPRLDGRYAKVGALAEIEQVGRLPGGERAAVLRAVSRARIGTGTTGPGAALWVEATVAGVPPADDRTHELAREYRALVTTILQRRGAWQVVDSVRQVDEPAALADLAGYASYLSDERKLLLLETDDVAERLTLLLEWGREHLAELDVAETIDKDVKEGVDKQQREFLLRRQLAAIHRELADLDGRPVTEEQDYRARVEAADLPGHVRTAALAEVDKLERTAEQSPEVGWLRTWLDTVLGLPWNTRTDDSYDIAGARAVLDADHSGLDDVKERITEYLAVRARRADRGLGVVGGRRSGAVLALVGPPGVGKTSLGESVARAMGRKFVRVALGGVRDEAEIRGHRRTYVGALPGRIVRAIAESGSMNPVVLLDEIDKVGSDHRGDPTAALLEVLDPAQNHTFRDHYLEVELDLSDVVFLATANVLEAIPAPLLDRMELVRLDGYTEDEKVTIARDHLLPRQIERTGLSDADVTVTDDVLQALAGEYTREAGVRQLDRALARVLRKITARVALGERSLPVVVDDPRPYLGSPKFTPESAERTAVPGVATGLAVTGAGGDVLFVEASLAARDTGATDVTITGQLGDVMKESARIALSYLRSHDERASVLATRGVHVHVPAGAVPKDGPSAGVTMTTALASLLSGRPVRSDVAMTGEVSLTGRVLPIGGVKQKLLAAHRAGITTVLLPKRNEPDLEDVPASVLDAVTVHLVSDVREVLDLALEPEVVTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY7</accession>
    <name>A0A7W7SZY7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="477" mass="51365" checksum="6FC2372B6368724D" modified="2021-06-02" version="1">MTAGPQAQPRVIAGRYTLLAELGRGGMGVVWRAQDTVIGRHVAIKELHLPDGIAPAERRVLEERVLREARTAGRLNDPAIVTVFDVVAENGMTYIVMELVEAQTLSTLINQHGPMPQDRVVSIALQTLSALEAAHQAGIVHRDVKPGNLMVGPTGRVKLTDFGIAQAMDDPRLTTSGSLIGSPAYMSPERIHGHEASPASDLWALGATLCYAVEGVSPYERSSTASTLHAIMNEAPRLTRAHGALGAVITGLLMPDPNARLSGPQARAMLERALAQPTPPQGLPPQQHTANYTQITRPPAKSWVRPVVTVAAVVAALAVFTGGVFAGRWLFTDTPPEAMQPTYTFGTGGRLPDFEVSDGDCGNNFLGDSVSISSTQCKEAHNVEVYAVGDPFGSQEKVDYPGEEWLTDYAEKFCTLHFQSSEVGPEDKETRLQYAAVVPASGEWRSDYSSSDGSRRVACVVWNKDRSLLTDKVHSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T015</accession>
    <name>A0A7W7T015_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4942" checksum="7D10EA99BD559E17" modified="2021-06-02" version="1">MYEHESWPEVIADALAGLFGFVFFFAVQFLFMWGLLELVEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T085</accession>
    <name>A0A7W7T085_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="4">
        <location>
            <begin position="326"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="610" mass="66102" checksum="8FFF09BB9B75AAC7" modified="2021-06-02" version="1">MGRTTALAVWLTALDFGHLRDVLTRRPDAAATRPHTLRALAEALLEPTSVDRAVDTLDQGCLDVLDTVVALGSDATADAVAHRLRCTGKASRSDLRRALTELRTCALVWPDGDALRTIPDRRPTAKPRRITSAPRAPRRVSVDRATVDNAATEAATALVEGIGRLLEHCDVHRTDSRSLPGARDANPHTARFRYTLASRAGLLATVDDRVLPTSWADAWADAHPAVRLARLVTAWLADSRHRSVVARHAELADGTAFADRDEAVADLVWSRRGTAVVLTEAEEVGLIASGALTGLGKAALDGVVDEAADQYVHAEVSRVRFLPDLSVAVRGLPNRALGRVLGRCAEHDGVYWRFTEQSVRRALDTGRDSVRVLAELSQVGDVPPELDTLVRSVARRHGRVTVTAVACCVRSDDRDLLLELLEHPRLTTLSLEALAPTVLASAKPVKETLARLRAAGYAPSGTGVDGTATIERAPRERGEPAPPPPRSRTIPLADRELTALALALSGRERSRATPLRADLRRAGTARMLRDESLVLRDSEVALLADALVTRTCVEIDFAHGPRTTTKHVITPVDHAAGNLKASLEPRGEHHEFAVGRIRSVREVREMREVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A1</accession>
    <name>A0A7W7T0A1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">F4559_000269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="14389" checksum="3CFC93DDDFB951A6" modified="2021-06-02" version="1">MARLAGVDLPREKRLEIALTYIFGIGRTRSKEVLKATEISPDVRVKDLGDDDLTKLREFIESNFKVEGDLRREVAADIRRKMEIGCYEGLRHRRNLPVRGQRTKTNARTRKGPKKTVAGKKKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H9</accession>
    <name>A0A7W7T0H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Holliday junction resolvasome RuvABC endonuclease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="18416" checksum="3465A41F03D7201F" modified="2021-06-02" version="1">MDAASARGNVIGLDLSITATGIAYPDGSTATVKTRSADGDRRLLDIVVAVNLALGSEPTLVVIEDLPTHAHAAGITGMVHGAVRAALLDAGIPYVLVPPATLKAYATGRGNADKTAMALAAFKRAQVEFGDDNQCDAWWLRHAGLDHLGVPPVALPEAQRNRLSVLRWPDLPARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0P5</accession>
    <name>A0A7W7T0P5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA (Cytidine1920-2'-O)/16S rRNA (Cytidine1409-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.226</ecNumber>
            <ecNumber evidence="3">2.1.1.227</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.226" evidence="3"/>
    <dbReference type="EC" id="2.1.1.227" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28311" checksum="E1DD526CD488D621" modified="2021-06-02" version="1">MPRRARLDAELVRRGLARSREHASQLVADGRVTVRGTVATKPATAVELDTALVVRDNDGPNYASRGAHKLVGALERFDAVVVEGRRCLDAGASTGGFTDVLLRAGARQVVAADVGRGLLDWRLRTDDRVVVKDKTNVRALAPEDIGGPVDLVVADLSFISLRLVLPALASCLDEDGDLLPMVKPQFEVGRERLGSGGVVRDPELRAEAVLDVVASAAGLGLRTHGVTASPLPGPSGNVEFFVWLRRGEPLDADTAAGLVRAAVAEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W1</accession>
    <name>A0A7W7T0W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="297"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="41931" checksum="EAA8A66EA3125EE6" modified="2021-06-02" version="1">MDGWFLRWGPYGLLALGTVASAATAPALMSTTDVLWAAALVVGALVWQRARGSLYFVVRGALAFALCWLNPFFSVFALMGYFDAGLHLSRSARRWGLLSVALTLALSQSAVPDGPPPDDVGELVVFAVLFALHATLALVLDRVNDREADKRRRQAVVIEELETVNARLAAALAENAVLQARAREAGITAERRRLAADLHDTLVQGLVGVVTQLQAALDTDGDGARARVERAVALARYSLGEARRSVHALVPGPLENRTLPEALREAVDRWSATATARVDLTVVGGVEPLHDEIESTLLRIAEEALNNVSRHAEADRVGVTLSYIDDEVTLDVRDDGKGFDPEHAPRPSDRGGFGLDGMRLRAGRVGGVVAVESEPGGGTAVSARVPAVPEAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T107</accession>
    <name>A0A7W7T107_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-2,4-diaminobutyrate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.86" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033983">
        <property type="term" value="F:diaminobutyrate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="48071" checksum="28384432006225C7" modified="2021-06-02" version="1">MFAARSSRRPLPAGRPFEVLAAAAHLLGPGLPHRGVGGPAALALVRRVLDEYGADLTSPFSAAHLQPPPLAVAVEADALASASNASLDTYDSGPATIAVERWVLGALVELAGFGAGDGVFTPGGTLSNLTALLLARDAAAARHGLDAREEGVAGLPDPVVFCSELAHFSVLRACAALGLGERAVRPVPVDARRRMRVDALEASLRLGGTPVAVVATAGTTDFGSVDPLPELAELAHEYGTWLHVDAAYGFGALFSDRLRGLVDGIAAADSVTADLHKIGWQPAAAGVLLVRDPDVFRALDRSVAYLNPEDDRAEGYDGTLGRTLQTTRRPDAVKVAATLLALGRAGLGALLDRCHDLAVRAARLIAADPSFDLVGEATLTTVVFRYRPADESRSDGVNAELRRVLLRRGSALVGRTRVDKATCLKFTLLNPEAREADLAALLALVREAGAAAERTLEEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T170</accession>
    <name>A0A7W7T170_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21225" checksum="B032EA4E31C44985" modified="2021-06-02" version="1">MKRRAARVPLAIAAFVLSLFPVVYLHVVSVGRISPVSDVVSDYIFVDNGTGLLAFTALTLAAGSVALLAHLVANGLPKRGPATVLLGLWSAGLAVAAVFPTDPTGVPTSFSGAVHRYAGAVMFTSLPLAGWLISRRFVRDTAVRRISLAAGVTALLFMLSHTSVLFPGHGAVLLGLFERILFALLYGLLFALAVAMRREVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T196</accession>
    <name>A0A7W7T196_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="DNA_pol_b-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017078">
        <property type="entry name" value="UCP036978_PHPhdr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036978">
        <property type="entry name" value="UCP036978_PHPhdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="SSF47802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="103"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="36086" checksum="158A5D98C11D976B" modified="2021-06-02" version="1">MAVDAGEALRTVAFRLERVGEPGHRVKAFRRAAGVVDELGVDEVARQVARGTLTDVPGIGPTTARVVADALAGREIGYLDGIVEPDYLDPAFGGHALRELLTGDCHTHSDWSDGGSPILEMATTARSLGHRWMVLTDHSPRLRVANGLSAERLRRQLDVVAALNVDLAPFRILTGIEVDILDDGSLDQDPELLDRLDFVVASVHSTLRMPAGEMTRRMVAAVRDPLVDVLGHCTGRRVAGKVRAESAFDARTVFTACRDHGTAVEINSRPDRLDPPRRLLSLAVELGCSFTIDSDAHAPGQLDWLHYGCRRAEECGVDPSSVLNTVSAEALTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B4</accession>
    <name>A0A7W7T1B4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stearoyl-CoA desaturase (Delta-9 desaturase)</fullName>
            <ecNumber evidence="9">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35378" checksum="4B6ED0FBF901E3F2" modified="2021-06-02" version="1">MSTQVESNVRRVDAAPQPMLAGEKSPAEMFLVKLFAVIPALALAAAVPPAWGWGLGWVDVGLVAFFYSLTCLGVTIGFHRYFTHGAFKATRALRITLAVLGSTAMQGPIIGWVADHRRHHAYADREGDPHSPWLFGTSARALAKGFWHAHMGWMFRRELTNAARFAPDLLTDPDIQRVNRWFPALTAGTLLAPALAGGLITWSWWGALTAFFWAGLVRVALLHHVTWSVNSICHMIGDRPFTARDKSANFRPPAILSMGESWHNSHHADPTCARHGVRRGQIDISARLIRVFEKLGWATNVRWPRPERLARNLRSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H6</accession>
    <name>A0A7W7T1H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24476" checksum="7E6045D9FC83D680" modified="2021-06-02" version="1">MRPVDLARAAGISAQQVRNHLAEGVLPPAERTPSGHRRFGEHHLAALLAFRALGRACGWDTARAVMHAVHDDDLSRGLALLDAAHADLHVQRLDLDRTAEALESFVEVAESVPRGGLRVGDLAARLGVRPSALRVWETAGLLHPARDRDGHRRYSAADVRDARLVLVLRRSRHGLSDIAPIMDRFRAAGGREALRAAVTARRSEVADRSRAMLDAAVLLHACVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K2</accession>
    <name>A0A7W7T1K2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="439" mass="47659" checksum="4FC73B8EB4A81815" modified="2021-06-02" version="1">MAGRGPVPAVRPVTADLVGRGRRQVEVAPASGLPRRTADGDTAAHWAGRAATRVPAGDARPGRHPAANERHGRRPPASGVPRPGRGHGRAGRDPAGNDRTTRPCPQRRTPSTGTVRRTRHPRSTTSLRPTRRVGRSRRRPARRDHPHPRPAHRRPPRPGAMPVTAILAALGPTGRSRHRDLRHHATPSGRQPENRSPATRTRRHRGRSDPRWRTLSPGPAPGVGPRPASRARSATPRASSPPGPGRPRRRHPWPDAAATSIKGGSAPDRVAAASNTSSPGFAAPSDPVGRTCHGRRGPRRETRRRPRRPAHRRSGRSSRHVPDRLRAACPDRPVGDTTTRITGQGPAPPAGRRTRPGPDRRVPRICPRARTVFRTATKPSFDGHDPRHCSPTRAKNLIHGRSLKTLRFHSDNSRIFPAVVALVLKVSGVSPELGLCINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M7</accession>
    <name>A0A7W7T1M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025358">
        <property type="entry name" value="DUF4262"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14081">
        <property type="entry name" value="DUF4262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18773" checksum="3A3CAF9B504EFECD" modified="2021-06-02" version="1">MSTPLSPQDRNLRNWLLEQSETNGHAVITVPQDDEGAGYAFSVGAWRRYGIAEAVVIGLPPEMAKMLLRMYVVRSVQGERFVPGKLYFDFFDGTPVTFEKVFKGFYAEFFGSAFLLYAKGDFAAVQIVLPTTDGHWPWSDNAPAGFADWQLLLTESGRPESWTPGVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V0</accession>
    <name>A0A7W7T1V0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="5">3.4.13.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="3">
        <location>
            <begin position="146"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38760" checksum="DA5848D89790FF67" modified="2021-06-02" version="1">MEALRARLGRATAAAAEAGVDALLISPGSDLRYLLGIGGSSFERLTCLVLPVGGTPVLVLPKLEQPGYAAVPVGELGVEFAPWVDGEDPYALVRKALKRTDRVAVADMMPALHNLRLREAVGGDQVLAGPVLRELRMRKDAVEVAALRDAGAAIDRVHARVGEWLKVGRTEAEVGADIAAAIVAEGHELAEFVIVGSGPNGASPHHSVSDRVIRAGDVVVVDIGGPLAGYNSDSTRTYVLGEPEFEDVRETYAVLEAAQRAAVEAVRPGVTCAEVDAVARRIITEAGFGEYFIHRTGHGIGLDVHEEPYIMGGNDLPIEPGMAFSVEPGIYLPGRWGARIEDIVVATEDGVESFNNRPHDLVVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2I8</accession>
    <name>A0A7W7T2I8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="32972" checksum="4A76B577AB9D9CC2" modified="2021-06-02" version="1">MSSEGDAAPVRPFADALRAAIAARGIGLERIREYLADHGVTVSVATLSYWQSGRSRPERRSSLAAIGHLEEVLLLPPGHLSNLLGPPRPRGRWLNRLPRAAPPVGALFPQPARVEDAAGEVRWDDRLTRLSRHDLVLVGPDRCEQSVRTRHVLRADADGADRWVLVTEASDGSLPLVKPLWHCDLGRVVVRPSAGLVVAELLFDRALRRGEHIVIEHELITPVPRPVATAHTRTFRHPVREYVLEIAFDPAAVPACCERFQRAGDGPERVVTAAPGSDGSLLAVQLDVEPGQSGFRWRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M8</accession>
    <name>A0A7W7T2M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein/D-arabinose 1-dehydrogenase-like Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="843"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2212"/>
            <end position="2287"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4068"/>
            <end position="4143"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="5652"/>
            <end position="5728"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="7214"/>
            <end position="7289"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="878"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="2247"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="4103"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="5688"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="7249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="7371" mass="772872" checksum="896F52B5A6C4BC7C" modified="2021-06-02" version="1">[encoded data, 7371 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U9</accession>
    <name>A0A7W7T2U9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="13017" checksum="D21E1278780C5708" modified="2021-06-02" version="1">MIPEIEATVIATVVRALPQVAGPHSGRYGEIATHLPGRRVAGVRVGPAGITVGVVVRYPATTAEVAAAVRAAVGRPASPLHVWIGDIAFPDTHLPVVPPSDAAARHAPARPGALPRRAPATTTRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z4</accession>
    <name>A0A7W7T2Z4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12764" checksum="F983D4B31E869D99" modified="2021-06-02" version="1">MTDGFFALVDALPEVERSEARDYSAFSVRGRRFGYHWPRTRTAGLKQTLSEQRALVAERPDVFEEQFTAGGFGWVVVKLDEVDAGELAELVFEAWRLSAPEDLIGSADDPARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G9</accession>
    <name>A0A7W7T3G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR02246 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14529" checksum="A8DAB69477FFD546" modified="2021-06-02" version="1">MNDTDADIAAIKQVVATVEHTQCHELVDEFVALFREDAVWTTGHGRLLTGRAEIAAFTAEVLPGGMMGLTATYEVVHILFIRSDVAAVKVRQRYLTLDGDPVEGGHEGSPLYVMSKEAGRWLLTACQNTGVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I4</accession>
    <name>A0A7W7T3I4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="419"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="639" mass="68435" checksum="906CCB564B3AB16E" modified="2021-06-02" version="1">MVKIAPYGTWTSPIGAADAAAAGGGPQWVDLHDGRPWWAEGRPAEGGRVALVRDGQDLLPPPWNVRNRVHEYGGRPWVVLDTPDGTRVAFTHWDDQRVHVFDPDAPVPEPVPITPAPERHHGVRYADLAAGPGGTEVWCVRETVTGDARTDVRRDLVAIPLDGSPIRVLAASHHFLSGPKPSPDGTRLAWIGWDHPNMPWDGTELCVARVGEDTHRVVAGGPAEAVCQVEWDGDDLLALTDPQGWWNLFRISPDGTSTNLAPVAQELGGPMWRLGHRWFATIAPGRYAVLRSGTPAVLDEAAGTVVDLDVDLPLWQSQLAVHEGVLVSSAAGPLDEGTVVSYDLGAGVLTRHTTPADPAERAYLPVPEERVFAGPDGDVPAYVYPPRNPDFTGPADERPPYVVHVHGGPTGRSAPVLDVDIAYFTSRGIGVVSVNYGGSTGYGRVFRERLREQWGVVDVNDCAAVAQALADEGTADGARLGIRGGSAGGWTSAASMTSVKTYRCGMVAFPILDLAGWTGTGGETHDFESRYVEGLVGPWPAARDRYVDRSPANRVDRLAGPVLLLQGLEDEICPPEQADRFVAALDGTGVPHAYLTFEGEQHGFRKAASIIAALEAELSFYGQVFGFTPPGVPVLPLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N0</accession>
    <name>A0A7W7T3N0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">G6PDH family F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="34621" checksum="72A14B6217F3D9C1" modified="2021-06-02" version="1">MRIGYTLMTEQSGPRDLVRDAADAERAGFDFEVISDHYFPWLAEQGHAPYAWSVLGAITQVTERVELMTYVTCPTMRYHPAVVAQKAATVQLLSGGRFTLGLGSGENLNEHVVGRGWPSTDVRQEMLREAVEIISQLFDGGYVDYVGRHFRVDSATLWDLPDRRVPIAVAVSGERSVGLFAPLADAMVAVGPDADLARSWDVFQGRESRKVGQLPICFDTDRDAAVARAHDQFRWFGDGWAVNAELPVPAGFAGATASVRPEDVAARIPCGADVGAVVAAVRGFHDAGFGDVALLQIGGGHQREFLEWAEKELLPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q7</accession>
    <name>A0A7W7T3Q7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="31700" checksum="247CFE6A0B9F1EF1" modified="2021-06-02" version="1">MIATIVLVLVIGVLRPTFLNPGQLLDVLNNSVYVALLAAGMAFLLAMREIDLSVGATFGLTLIVTALLIRSGVNSWLAMVVGIGLGAVLGLVNAMVVRYIAIPAFVATLATMQVFRGLAVALGDGQQVNGLPLDDPFFVVLGGDFLGLPVSVWILILVTAGLTALLRWTPFGYRVRSIGSNPDAAAFSGISIANTRTLVLVLVGAVGGLAGVLGLAFFTSGDPNIGLGFELQAIAAAVIGGTPLRGGVATVVGAVFGAILLGVVDSGLVYFNIPANWSAFTTGLVVLLAVGVDSALRSRRRARESAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T452</accession>
    <name>A0A7W7T452_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031312774" evidence="6">
        <location>
            <begin position="34"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="7">
        <location>
            <begin position="483"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="602" mass="61459" checksum="23879D3E2E7692DC" modified="2021-06-02" version="1">MGDTRTTRRLATLGLAAVSAAALALTNPAVASAEADVLGADRADAIAGSYIVALRDSASPRALSNSTADSLVKKHGGQVRTAWQHALNGFHASLSPTQARRIAADPRVQFVQADLPVKITGTQTNPPSWGLDRVDQRNLPLDNKYTYEQTASSVTAYVIDTGIRTTHQDFGGRATWGTNTVDSQNTDCHGHGTHVAGTVGGTSYGVAKQVKLVAVKVLNCQGSGSSSAVVNGINWVTSNARKPAVANMSLGGGADSAIDSAVRSSINAGITYAIASGNDNKDACSSSPARVTEAITVNATTNTDGRASFSNFGTCTDIFAPGNGITSAWKDSDTSTNTISGTSMATPHVAGAAAIYVANNPSATPAQVATGLYGASTPSKVTSPGSGSPNRLLYIEATAPQTPPVITNPGNQSTAVGSPVNLQLAATGGTPPYSWAFSGLPAGLNGNASGLVSGSPTTPGSSTVNATVTDAANQKASVTFTWTVTPVSQNCDEATNGDDVQIGDQSDVSSSISVQCSGNASATTTVKVDIVHTYIGDLVVDLVAPDGTVYNLHNRAGGSTDNIAKTFTVDASRSAATGTWKLRVRDQAYVDTGYINSWSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T462</accession>
    <name>A0A7W7T462_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10947" checksum="DFA878A70EC205A1" modified="2021-06-02" version="1">MVDGADHLRQALAEYPLGWPFDFAVLSAVHADLASVLVADGELAVEVPEPVLLSEPAHGTEGVVRDLREVIPARVDHVPPEVLDRLDEFTGRRREAVSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T467</accession>
    <name>A0A7W7T467_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="32432" checksum="7B0266F5820CCD3B" modified="2021-06-02" version="1">MRAVLVVAGLVGAVVALIRRRPRVAPGYTAIPRTHFLLRVPTGMAVDPALPGLVRPGAGTSVLVAVNPLTPDADAEEILTDLATGFTGVRAAAQGLELDRPQRLEVAGFPAVATTGIQRVGDARVRKAVVALITDDEFVMLTATLADDDPLSTPEALAVLTAARRGATRAPGDLGFDVTPAPGYHRSSHPGSALLLTLGPETGDDVPVFVVAASVDDVATPDEDRRDAALGRFAALPSTPTVDDAAAVEIAGLPGYEITGRGTGRWEAVYCTVLFRPAGYLVLSGWYDPLVHDDQHPAFRAMARSLVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C6</accession>
    <name>A0A7W7T4C6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13011" checksum="8937958908B45376" modified="2021-06-02" version="1">MRKTPHVTLRPSWCVGPLWIRWSEGIAEPHDADEAAAVLGLDDDLRAAITAWDERFQATFDPTYPPDSAFPTSEDEAAWLTEGRRLALRLRAALPHLSVDHETIGGRAVPLDEDTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G1</accession>
    <name>A0A7W7T4G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="50344" checksum="AD2159A91080DA1E" modified="2021-06-02" version="1">MTRTEPGPTATQAPAADWGHLWPHFTRLSAPRTPLITRAEGAYLYDERGRRILDGLSGLFVVQAGHGRRELAEVMAEQAAELAYFPAWGYATPPQMELADRLAAAAPGDLDRVFFTTGGGEAVESAWKVAKQYFKLTGRPLKHKVISRAVAYHGTPQGALAITGLPAMKQQFEPLTPGGFRVPNTNFYRAREHGDDLEAFGRWAADRIEEAILFEGPDTVAAVVLEPVQNSGGCLTPPPGYFRRVREICDKYDVLLVSDEVICAFGRHGTTFACEKFGYQPDIITCAKGMSSGYAPIGAMITTARVVEPFLRDKVAFPHGYTFGGHPVAAAVSLANLDLFEAEGLNRRVLDNEGAFGDTLRKLLDLPIVGDVRGDGYFWAVELVKDKNTRQTLDFDEREHLIRGFLPKALFDNGLYCRPDDRGDPVVQVAPPLICGQAEFDEIEQILRHTLTEAAKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R2</accession>
    <name>A0A7W7T4R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="49617" checksum="8AD50B6130C167D8" modified="2021-06-02" version="1">MNAGSKSLRHPAEREVPTAPGRLPVIGHGIAMLRGKLAFTAGLAAHGDIVRVHLGTLPVYFVTSAELIDQVLATETDKFDKGALGDKLRDVFGNGLVSTNGDFYRRQRRMIQPAFHRRPIGRYTAMMAESAAELADSWRSGQVVDVERAMQDLALVIAGRSLFSLDFAREVRDVIRDEMPVMLRLGVVRAITSTPLLERLPIPANRRFDRAIARVHAVVDRVAASAREDRDDLLSALVRARDENGEPMSREQVRDEVVTLLVGGSETTGNTLAWLFHELAAHPDVLDRVTAEVEEVVGTRPVAFEDLNALPYTRRVVSEVLRRYPLWFMLRRTNTTVSLGGVEFPPGTEIGFSTHAVHHDPRYHRDPDVFDPDRWLPERVGALPRGAYVPFAAGLHHCPGHFFAMAELMVVAATVLSRRRLVPVPGRPPRPRVTGLIYPGPLPMTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R3</accession>
    <name>A0A7W7T4R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine-rich copper-binding protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025141">
        <property type="entry name" value="DUF4082"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13313">
        <property type="entry name" value="DUF4082"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031345951" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="4">
        <location>
            <begin position="136"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="290"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="4">
        <location>
            <begin position="406"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="559"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="4">
        <location>
            <begin position="674"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="3">
        <location>
            <begin position="828"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1095" mass="113431" checksum="352FED482B5962AC" modified="2021-06-02" version="1">MSGPLAFAVLAATAVVPSVLYSPAAIAAPEATAPTVQITTAPTTSVVGTPYTFSGTVADDGTVTSVEVSTDGGVLWRPATYTQTTWTHTYTPSASGTAQLRVRASDNEQLVSAEQSASATVAPRVCPCSLWSDGDTPATPDAADASALELGLKWQANSNGYVRGVKFYKGPNNSGTHVGSLWTTGGVRLATGTFANETAGGWQTLLFSVPVAVQSGQTYIVSYLSPTGHFSLSGNYFATSGRHLEPLTAPQAQPNNGNGVFRAGAGFPDLNSSGSNYWVDVVWAPDAGADTRAPGLVTTQPKANAGTVGLQPSLSAQFDEQIDPATVEFTLTGPGNATVAGTVSATGPTTNFTLGTPLATGTTYTATVRARDAAGNQADAYNWTFTTGSPRPANCPCTLWDDFSAPLEFAADDGQSVEVGTKVRFDGRGEVLGVRFYKGAANTGTHTGSLWSAAGVQLATGTFVNETSTGWQTLLFSSPVAVQANTTYVVSYLAPHSGYGFTSAKFANEESSYGAIHALKDGVDGGNGVFKYGSGFPNSSHNATNYWVDVVYRNGLNGDTTAPTLVTRTPAADATGAALSGALTLEFDEPVDPASTQISLTDPAGATLNGAVTAFSPDGKTITWTPTAALVGQTKYEAKALVADANGNPMSAVAKWSFTAGAGTGPVSLFSRATVPDVQYVADGGLIELGVRFGTSHHGRITAVRFYKGVGNTGTHTGSLWSPEGALLATGTFSGETATGWQTLTFAQPVTVLPGRIYTASYTTTTGHAVNYSYFQNRAVEAPPLTAPGNTWNSANGVFKPGGGFPTTSHQGNNYWVDVEYVATDDYVAPTGTGHTPLTDATAVDVTSTVTASYNEKIDLANTTFTVTDGAGGKITGTVARSADEQTAIWTAASPLAPGTVYKVSVKASDLAWNTPAEPITWQFTTTGTTAGPWSLFSAASTPKITVNPNATFATVGVRFTPTVNGKITAIKFYKGEENTGTHTGRLWAVDGKTLLKTGTFTNESTSGWQTLTLDQPVDVTAGTQYIASYYAPTGKASYDAGYFIGYSVTAGNLTAPQWSSTAPNGVVGTDETSFPESYATGGNNYWVDVVFTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E4</accession>
    <name>A0A7W7T5E4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031423736" evidence="1">
        <location>
            <begin position="28"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="40210" checksum="B307731B391F5D60" modified="2021-06-02" version="1">MGKALRACLGVALITMLTTVPTGVAEAAADPPAIIDLGTLPGDDGSGVTTLNNADTVIGYSRWRRAPGDATSTYRPVKWNAAGVISALPIPPGDTNSSHVVVDLNDSGVIIGNSTDAVASGPTDRGLRWAPDGTVKVLAPLPGDTASRATDVTADGTVLGQSWRQGSPARVALWSPDGKATTLPVPSGYDRSSGGAINDDKVVVGNAEGPGKPRLTLLWKPDGTYVEIQDRVGYPFLINNAGAVAGWSPGFRCVKLNPDGTVVDLGPYGQLATLTAAGAVAGGIGNPPYWQPTRWTPDGTATTLPRLPGDQVGSVADIDDRNVTVGASTHVVSTIVREHHAVYWTPDGTLVPLGALPGGKESWTRAINSKGTIAGNSSSPRGERAVLWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S5</accession>
    <name>A0A7W7T5S5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmotically-inducible protein OsmY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="8844" checksum="8CA9E34CF2943B8A" modified="2021-06-02" version="1">MTAEQYLSARLRRALAEDPRTAELGVRVTVRGDHVLLSGDVACADRRADLEAVVHEAAPGVTVLDDVRVVPVGEPVGQEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U3</accession>
    <name>A0A7W7T5U3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="503" mass="54198" checksum="43B1839BE46AB55C" modified="2021-06-02" version="1">MQPLPPDAPSRIGDYLLLAGLGCGAMGSVFLARSRGGRPVAVKVARPELADNSEFRERFRREVEMARSVGGFWTATVVDADPDAERPWMATEYVPGPTLQQAVQEHGPLPERAVRRLAGGLAEALVAIHGAGLVHRDLKPSNVLLAADGPRVIDFGIARALEHSALTEAGIVFGTPGYLSPEQVVGAEITSRSDVFALGSILVYAATGAGPFGEGATSALVYRVVHQDPDLARIPPGLAPLIKPCLARDPADRLTPSRLLELVGPPSAEPSWLPERIRSLVEARHTELSRLDAKPPTRVAAERRPPTRVLVEERPAPTPPRRRTAERTPAKVTATGKSFHTSRVVGLTWTGVNVVAATVCAAVAGAGTDAHPAVRAAALVVFLVFVLAAARLFVGSVRTQLKLDVGPQGLTLSNGEETTRVPWYAMSRVHIDTHRARPWVVVHLTSAGWVPKPLGRGSFAKHKGGGLRVYPVSHERYRKRRERDLVELRSALAWYGTKVYDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y2</accession>
    <name>A0A7W7T5Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="22328" checksum="8F745A8237F6462B" modified="2021-06-02" version="1">MPTVVLIHGGLWEEMDAERFWVVPGIVSALRRRGIEVLAPDRGHRATGWGQEVDHMAPMLPDHPVTMIAGSNGCSVAVRLASTRPGRVARMVLAWPATAADPVVDESTRRRLTRLGATAAVVDELLSGGVIRGVSDTALESLTMPVGLVPSEPENPFHQRLTIDAVKALVPHAEELPGSAEPPRPEFATQVEPFVDAVTGFLTGNVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y5</accession>
    <name>A0A7W7T5Y5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ORF">F4559_004553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="614" mass="63658" checksum="57A61D8914EBD57A" modified="2021-06-02" version="1">MAPPAGQIRPAKYLGAFVLIVVALYSLVFFTGNHKPTPKLGIDLQGGTRVTLTARAPDGKTPSDEALDQARMLIETRVNGLGVAGPEVVRDGTNLVITVPGTDSEGAKRLGQTAKLNFRKVIGSPVPNAEATPESTSPSAPASGSAAPTTSASTPPPASETASAPTTTAQGRPAPAVEAQQPTTTAPADSSAPPATSASAPPTSAQPEPADCDKVLLAGEYSDDATKAIDESRQCRQNPQWAALDPQVVQQALGAFVCPKIDPLLGNDDPALPLLTCDQDRTQKYLLAPVTPPADGSVKDDDYSMYSRLTGEDIANAISGANPQGAGFVVNLDFKSEGGAKWGKFTSANVGQLIAVVLDSQVVSAPSINEAILGGSTQISGNFNQKEADGLANVLKYGSLPLSFEPSEAETVSATLGLASLEAGLIAGGIGLALVFLYCLFYYRLLGVLTILSLVLSGVVVYAVLVLLGRWIGFTLDLAGIAGFIVAIGITADSFVVFFERLKDEVREGRTFRSAVPRAWVRSRRTILSADAVSFLASAILYFIAVGQVKGFAFTLGMSTVLDLVVVFLVTHPLVVLVSKSKSLSNPKLSGLGGAVQAGAEERALAKSAAVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6H0</accession>
    <name>A0A7W7T6H0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="28059" checksum="B86EB9FB2571AB77" modified="2021-06-02" version="1">MSVVASGGGLSADVEEVLARLDDGRFSHRVTVYRVGATTLFGLGASYRNGEHDRGDRRVVLLTEHDLTDPVVLALCLVVAGLDRGSVVLGVPVSLTTARVDEAVLDLRARSVARQRELGHGSSASSGADVPPWPVPRAGHLVDGLGDDLLPDVDLYSWEGRHTAARLRRWAALLAARAEFQSPWDNDRELSGPDYRLVRLRFLVVATNTLVVPHGTVHDGDPGSDELDDLLSAALRRRSWETAVRIDAVQTTALGGDDAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6H6</accession>
    <name>A0A7W7T6H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent peptidase ImmA (M78 family)/DNA-binding XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="43568" checksum="77B0F743121FA815" modified="2021-06-02" version="1">MPTADRAAEVAAFFDGARLTMARHLAGLRKSDLAALIEKSPTAVGGWESGAKRPTAATVAQLALSLAVEPGFFAIRPDDIAALSTTPHFRSLRSTSQLARDQAYAYGQLAVDIAGSLERHVEFPEPNVPNFPVTVTSPDDDGPERAARLVREQWGMEDGPAGHLVRLLENHGLLVVFSPPQAATVDAYSFDSRLRPVVILNPIKRDYYRQRFDVAHELGHLVMHGDAEPGGRAVEDQAHRFAAELLMPAEQIRDHLPMSMGGNAWRSLARLKEQWGVSIQALLYRARWLGRLSDVSYRNAMTTISTRGWRRDEPGLITVIEQPSLLPRAVELLAQEGIEDTILIEQCRVPPDLFRVVTSRTPESGGLHALPTTQRAGSRVVSLLGQRPHIEVGHPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K9</accession>
    <name>A0A7W7T6K9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031284294" evidence="2">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="20662" checksum="884AD2D968765D44" modified="2021-06-02" version="1">MMRRTTLPVLAAAAAILIAGCSEKSPGRPSSVATADSGTTRTPGTTGSSSAKGDLNPERYADKPCELLKPAQLSGLGSFKAPESDKGVLGPSCTWYAQKVLEGTTYEVTVVTDGTRFPDMVSNTKDEPVFREAEVAGYRAVSSDGTDGKGNCGTSVEVTGAGGWFLLQASVENKKSPDYTDTCATTEKVAALVVQNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N2</accession>
    <name>A0A7W7T6N2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="512" mass="52935" checksum="505DC1DDF310C931" modified="2021-06-02" version="1">MSAPTETEPMTHRQVLEALSGLLLVLFVAMLSSTVVSTALPKIIGALDGSQTQYTWVVTATLLTATATTPVWGKLADLFDKKTLVQAAIVVFLIGSVVSGLSQNAGQLIAARAFQGIGVGGLQALVQIVIAAMIPPRERGRYNGYLGGVMAVATVGGPLLGGLIVDTSWLGWRWCFFVGVPFAVIALFLLQATLKVRTVRRPDVKIDYLGATLIAAGVSLLLVWISFVDDSFAWLSWQSAAMVGGSLVILAAAVRVEARAAEPVVPLEIVKRRTTALAILASLAVGMAMFGGAVFLGQYFQIGRGYTPTEAGLLTIPMMAGVLGASIVSGRMITKSGNVKPYLVVGTIALVPGFAALGTIDHETSLVLVGGAMLLVGVGVGMSMQNLVLAVQNTVPLRDIGAASSTIAFFRSLGGTIGVSVLGAVLARRVADRIHHDLAAAGFPTSGGGSAGSLDLSALPEAVQHIVRAAYGDATGHIFVISAGIAVVGVLASLAFKPIRLRSSLDLTADRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6V7</accession>
    <name>A0A7W7T6V7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">F4559_005022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="255"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="261"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="308"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="378"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="402"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="482" mass="52492" checksum="DBA0E12B186F2CCC" modified="2021-06-02" version="1">MTENTQYDTDRFDDRDDELSTGDLALADRAALRRVAGLSTELQDVTEVEYRQLRLERVVLVGVWTEGTAQDSEASLAELALLAETAGSEVLEGLVQRRDRPDPATYIGSGKVTELRDVVIATGADTVICDGELSPGQLRQLEEKLKVKVVDRTALILDIFAQHASSKEGKAQVELAQLQYLLPRLRGWGESLSRQAGGRAGGGNGGVGLRGPGETKLETDRRRIRARIAKLRRQIEAMGVIRETKRHHRVVNSVPNVAIAGYTNAGKSSLLNALTGAGVLVEDALFATLDPTTRRTTTPDGLPFTLTDTVGFVRHLPHQLVEAFRSTLEEVADADLLLHIVDGSDAMPERQVKAVREVITDISSRRDDPMPAELLVVNKIDSVGELGLARLRHLFPGAVFVSAHTGEGIAELRERVAGLIPRPDVVIEALVPYSRGELVARVHREGEVLKERHTGEGTELSARVRPDLAGALERFAVDGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7B5</accession>
    <name>A0A7W7T7B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase / fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.3.5.1</ecNumber>
            <ecNumber evidence="4">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4"/>
    <dbReference type="EC" id="1.3.5.4" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="28163" checksum="3A28D2BB4334D66A" modified="2021-06-02" version="1">MGYQGHFRVWRGDASGGGLQDFTVEVNEGEVVLDVIHRLQATQTADLAVRWNCKAGKCGSCSAEINGRPRLLCMTRMSVFAEDEVVTVTPMRTFPVIRDLVTDVSYNYEKAREIPAFSPPKGVAPGDYRMSQVDVERSQEFRKCIECFLCQDTCHVIRDHEENKEAFAGPRFLMRIAELEMHPLDEADRLDAARTEHGLGLCNITKCCTEVCPEHIKITDNALIPLKERVADRRYDPVVWLGNKLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H8</accession>
    <name>A0A7W7T7H8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="21089" checksum="F0D56F9A7029D636" modified="2021-06-02" version="1">MVDGLDGLRWQVHEKRRVYESDWVNVDLVKVEPPKTEPFEHHVIKLHHVAVALLINENEEVLTLWRYRFAVDQWGYELIGGLVEEGEDPAETAAREAVEETGWRPVGEPEHLGTFQPLPGIVDAPVNAYIWRHADKVGEPTDGEEAARIEWIPVDRILELVMRGEVLGSGAIVPVLFYLASRGAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I1</accession>
    <name>A0A7W7T7I1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-formylglutathione hydrolase FrmB/multisubunit Na+/H+ antiporter MnhB subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="432" mass="45886" checksum="F0D2837DE7A3EEAA" modified="2021-06-02" version="1">MAGPLDLSLIEGPIPVTATVVAALALAYLAIRRNRTWWTRVLPVVVSVCALVVTGATLVVDHVWKPWPEPLPPVLAVWSGAVLVASALAVLRLRSGRWYGRVLGVVLAAAVAAGGLVAANAYFGQYPNTRAVLDVFRNDRVDLDAAAPPPTDVVEVPAGKRLADVWRRPAGLPDRGTVSEVTIPGALQARPAWVYLPPAYHATPRPRLPVVVLMAGQPGSPRDWFDGGRLADNLDAYARGHDGLAPVVVVADQLGKATANPLCLDSALGRAETYLARDVPAWIERRLTVDERREAWTVAGFSHGATCSVQLAVRASDVYGNFIALAPQGEPTLGTRQETVKAAFGGDEAAFTRVNPLDILAGGRFPGTAGVIVAGRDDGTYRQADAAVFEACRKAGMDVLWNELPNGHDWNLARQGLFGSLPWLAARTGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Q3</accession>
    <name>A0A7W7T7Q3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22895" checksum="2CE28A9E48CD461A" modified="2021-06-02" version="1">MEMFEVIRQRRTELGMSQADLATAVGVDKRQIRRYEANEAQPNLVVAKAVADALGITIDELAGGDSRRLNLAGDWWAVWQTWNDGQEVINPHQAHMTQRGDQLEIVATTRGTQEFEKGGYLWRGEMRLWDNEALMGWYVAAEGGVRSKGTMYFALHQHGQRMTGRWVGLSYDGPIVTGWAAMARSESEATALINELREQGEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S1</accession>
    <name>A0A7W7T8S1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10866" checksum="BE95C4A0A0250BD7" modified="2021-06-02" version="1">MASGGVLTAVAGSVAVLVFVVVWRRRSVRRSRAGGVRVFSLAGRTVVGASVIVTCQWLALTHPDTTTVVRVAALGLPALVASWSLVRAVTVTVVDDRRRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V5</accession>
    <name>A0A7W7T8V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein EngB required for normal cell division/ElaB/YqjD/DUF883 family membrane-anchored ribosome-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="2">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="596" mass="65449" checksum="1EB6AEFB590059CF" modified="2021-06-02" version="1">MSAPWLDVLDDTIRACTTHNRPDLALRLREKRARQLDPKVRVLVVGESKQGKSQLVNALVNAPVCAVGDDVTTTVPTFVQHAETPSAALVRGADAPTERIPVPIDEVADQVSTEHGGDLVRAEVGIPRDLLTSGLVLVDTPGIGNLRSAHTASTFATLLQADAVLMVSDATAELTASELDLLGRVTQSCPTVFVVLTKIDLTAGWRHVVRRNREHLARAGIAARVFPVSSALRLRAAKTGDRDLNAESGFPELIECVRGDIVAAADVLARRTVTVLAAAAIRQLVVPVREELTAPRRTEDVVAALNEAQRRVDELRRRSARWQTVLADEMADLVSDVEYDLRDRTRRILREVDRTFETADPAVGWDEFGAWLEERLTEAATANFTWLLDRAEWVAEKVARSFPVHRDGLLPESVFPDDALDRVSTMDRPVIERFGVVQKFFTGLRGSYGGVLMFGLVTSLAGMPLINAVSLGAGALFGGKSILDESGQRLRRRQSAAKAAAQRHVDDFFLKFSKDCRDAARHVQRSLRGHFSTLADELQETLLESARGARRAVQEDTVHRERRLQEAKRELDRLVELYQRVQASAAGQAPPLGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B7</accession>
    <name>A0A7W7T9B7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar basal-body rod modification protein FlgD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="14996" checksum="6DB6A4A94F745617" modified="2021-06-02" version="1">MTSPIGGTSYTAATTTTQKTAPTTQTTSTTGLKSDDFLKLLIAQIKFQDPTSPTDPAQFMSQTAQLTQVDVLNKLAAQQETLLTSTVSARAADLVGKNVEYLDADGIRHTGVVDSATFGSDPTVRIGKTDVALSALTAVSGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D6</accession>
    <name>A0A7W7T9D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion-transporting ArsA/GET3 family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="34921" checksum="94D19C276A3108BC" modified="2021-06-02" version="1">MTGWTDELTRARLHVVTGKGGTGKTTVAAALALALATGGRRVLLVEVENRQGIAQLFDRPPLPYAEERIATAPGNGEVKALAVDPEAALLEYLDMFYNLGFAGRTLKRMGAVEFATTLAPGLRDVLLTGKVKECVRRTGANGRHEYDAVVLDAPPTGRVVRFLDVTRAMADLAKVGPIKGQSEGVVTLMHSGDTAVHLVALLEEMPVRETLDAVAELDGADLRPGAVFTNRVRPSRLPARSIAAAAAGRVDANRVRSGLEAAGLTASPDVLDGLVDQVVEHAIRVDMEARAKDKLAESDLPTLELPELADGVDLAGLYELAEIMVAGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F5</accession>
    <name>A0A7W7T9F5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17182" checksum="14627984B2611953" modified="2021-06-02" version="1">MTTYTADLVVLAPRGGVPNLLLIERGKNPFANRWALPGGKVDSGETFTQAALRELVEETGVRVGYSALRRVGMYDEYGRDPRGRYVSTAFLVVLGEMPTAVAGDDAADVRWVPVTELDPVELDRLAFDHGRIVSDALAAWQVERAYLPHLGALITAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R3</accession>
    <name>A0A7W7T9R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="41" mass="4605" checksum="9304C3494A159345" modified="2021-06-02" version="1">MIDVVESFNDVFEGSPLISVQATEYHKIPGSSDTRSKYDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG4</accession>
    <name>A0A7W7TAG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="36208" checksum="0EE122B6E6E99C87" modified="2021-06-02" version="1">MPDESTPASGDETTPAGIRHAVSPDRTRRVRRLRAEVEEAHSLLRLQEDAAPLEVDSRRVRRHRRRAVQAGRLHALAQDAAARAWQASRVRSVLTLVALTALVGALAWSTTGVHLTLTLSTAPGSAAWWGAWAVEPVISAVLLVVVAARAYLSTRGRVLDHPQLDRVERGALAVTLTLNVWPYLPFVATRFDPMTLLAHAIGPLVAVAAVTVMPVIWAEFAALDHGDTSPGSHVPTPSSEAVTEETRALASPAAEPVQEDVVTVPTGVGTPIVQAQQLPTLSKRAAELLPEVDAAIAAGQLPAMPSGSAIRARFRCGSEYAREVRTYLSERHEGEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG8</accession>
    <name>A0A7W7TAG8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ORF">F4559_006890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="97"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="213"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="470"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="588"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="325"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="752" mass="80291" checksum="F4AEE4B81A9ED9B9" modified="2021-06-02" version="1">MTDTVKHAESTPDQEQPYKELGLKDDEYARIREILGRRPTDAELAMYSVMWSEHCSYKSSKVHLKYFTETTTDEMRSKMLAGIGENAGVVDIGDGWAITFKVESHNHPSYVEPFQGAATGVGGIVRDILAMGARPLAVMDPLRFGPADAPDTRRVLPGVVAGVGQYGNCLGLPNIGGEVVFDATYAGNPLVNAMCVGSMRVEDLHLAHASGTGNKIILYGARTGLDGIGGVSVLASETFDDTAGKRKKLPSVQVGDPFTEKVLIECSLELFRERLVVGIQDLGGAGLSCATSELASAGDGGMRVQLDRVPLRASGMTPAEVLSSESQERMCAVVRPEDVDAFMAVCAKWDVIATEIGEVTDGDRLVITWHDEVVVDVPPRTVAHEGPVYHRPVQRPDDQDALQADTPDQLARPAADEVLDLVKRMAASPNLASREWVTQQYDRYVRGNTVLAQPADSGMIRIDESTHRGVALATDCNGRYTRLDPYTGAQLALAEAYRNVATTGATPVAVTNCLNFGSPEDPAVMWQFERAVKGLADGCAQLGIPVTGGNVSFYNQTGSTAILPTPVVGVLGVIDDVRRRIPTGIGAEAGETLLLLGETHAEFGGSEWAHVVHGHLGGLPPKVDLAREKLLGEILVAGSRDGMLSAAHDLAEGGLAQALVETCLVGEVGARIFLAGDAFTELFSESAGRVLVAVPRTEELRFTDMCTARGLPWRKVGVVDPESKALEFQGLGELGLDELRAAWSGTLPALFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBC5</accession>
    <name>A0A7W7TBC5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
            <ecNumber evidence="7">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030926294" evidence="5">
        <location>
            <begin position="24"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="29"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="385" mass="42806" checksum="A0C9756F2B9227B8" modified="2021-06-02" version="1">MRLLLAACAALLVVTGLSVPATASPPRGHVVGAYYGNWFSGSKPISAIPSDTPITHLFYAFSTIEDGKCVLNAPTAAKDFADIVDLKRRKPSLRALISIGGWGAGGFSDAALTRESRRDFVASCVDRFFEQAPGVFDGVDVDWEFPVYGGPTEITDRPEDRRNATLLVREFRRQLGKRLVTAALPTGRLQTDGPYDPAKSFELEELGRELDFITLMTYDQGTGFSKVSTFNAPFQQVREDPLPRADKRWNSTVGAVDYYTRHNVPARKLVLGVPFYGRGFTVASEGPDHGLYQPVVNAFWVDGRDEVEALRKTPGWTEHWHPVAKSPWLYNAAERRFVSYENPRSIGLRADYAKRRGLLGTFMWELGHDDADHTLLTAMSAPFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBD4</accession>
    <name>A0A7W7TBD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09022">
        <property type="entry name" value="Aldose_epim_Ec_YihR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037480">
        <property type="entry name" value="YihR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31174" checksum="62D806BD61E0E6C8" modified="2021-06-02" version="1">MLEIAYADARAVIAPVGAGLRSFEVGGVPYVETYDDVPVLGSGAVLIPWPNRTAEATWTLDHEVQRLEVTEPARGNAIHGLVRRVEWDVVEHTGSLISLLVAVKGHGWPVELRTTITYALDDRGLTVSHGVQNVGAARTPFGVGTHPYPRAGNSATDETTLRLAATTVLPLDPDTMIPSGPASPVAGQHDFRTPRLLKDVRLDTAFGGCEPVDGLVRHELRGPAGGVELWADPDFRWVQVFTPGDFPGRGRAVAVEPMTCPPDALNSGVDLIWLEPGDQWAGRWGLRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT75</accession>
    <name>A0A7W7WT75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Broad specificity phosphatase PhoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23557" checksum="59036AA7870825CB" modified="2021-06-02" version="1">MTRTVVHLLRHGEVHNPTGILYGRLPGFRLSDRGRRQALTVAEHLRDHDIAHVVASPLDRAQQTAAPIADSHRLELATDDRLIEADNRFEGLKVAVGDGALRSPKHWPKLVNPFKPSWGEPYLEIAHRMYGAVQRARLAAEGHEAVCVSHQLPIWTLRRFVEGRRMWHDPRRRECSLASLTSLVFQGEELVRVVYTEPVGATNPRVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTC7</accession>
    <name>A0A7W7WTC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26857" checksum="526EA59249D71B58" modified="2021-06-02" version="1">MRWLRNEVVAGRVAKGISPAVTFHADIGDWFVVGFEHFDGRPADLAPGSPDLPAVADVVNRIGEVEAGGLRSLADRWSDTDWWSRLSGTRPEVVDGWDVDAATRLSARIPGLVAGDSLVHTDLHGNQVLLGDDGAVRVVDWGLPASGARWVDPTMIVLRLIEAGHDAADAERWARSALPSFAEADDETVTAFACYLAGLWTFWAVDSPGPGVVHRAVLARHYLRYRLLGNASANGAMPIRRGFGTEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTL4</accession>
    <name>A0A7W7WTL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="31469" checksum="E7736C53CE4E77ED" modified="2021-06-02" version="1">MTSVSLLGGADAAPIVLDATPARVPTTRRYLMCEPRHFTVEYAINPWMDPTRPTDTSLAVAQWTALKETYERLGHQVEVIEPAPGLPDMVFSANSGTVIDGRVLGAKFRAPERAAEADHFRRWFLANGYQDVVMPEITNEAEGDFTWTGKYLLAGTGFRTDPRAHAEAQEVLGVPVISLNLVDPRYYHLDVALFVLTEDLVAYYPDAFSVGSQEVLRRLYPDAILATASDAACLGLNAVSDGRHVVLPVEATALGEQVAARGFEPVYVDISELRASGGGPKCCTMELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN4</accession>
    <name>A0A7W7WTN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18446" checksum="E2C8E7523DD3935E" modified="2021-06-02" version="1">MDHVDHVLAQWSRQRPDLDVSPMAVIGRLARLNRAILAEQQRTFASHDLDRPSFDVLATLRRSDPPHRLTPTQLMRAAMITSGAVTQRLDRLEARGLVTRGPNAADGRGVVVELTDRGRELVDRALPDHLATEQRLLHALDEDGRAELAGILRTVLESLGDRWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTQ6</accession>
    <name>A0A7W7WTQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27703" checksum="D4B855C382F84390" modified="2021-06-02" version="1">MSDLPPVRDLPPYRQARIRAVLQETVDRPRPLRRLAPVLVAAVAGLALVTTLAAWQRSGTEGAGTEGIGLGSAPVATGELPHHGAKLDLDPGRIAEIEAGCAQSANLSGKVRLYHYLEDRYGKIAVLYNSKEGVACALDEPGKPPFHSLLVLGGDMNVLPGVISRDTMLAWTSAAGHINVTIGRVAADVAKVRFRHGGQESLITPLNGVYLIRSVEPGDSTSSKIEALSADGAVIGDADCGFPVLDSNGVTGPGIGDCPPKGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU56</accession>
    <name>A0A7W7WU56_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="329" mass="36137" checksum="F506F55F785F8017" modified="2021-06-02" version="1">MTTATASTSTTRSRVGWGDLLWLTWRQHRWVVSVTTALLVLGCAITLYLATTVEAPAIDAELFGMGYHGLAQFAAGSHWLVGVLVAVFWAAPVVSREFEQRTHLVVWGQNLTPGRWALGKIVLLGAPAVLLVAAYTQCLRTLLISLNEVAAADRTHVMYNLFDQAYEISPLVQAGYTAFGFALGFAVSALSRNTIVSMAVTLIGYGVVRMLVTLLWRPNFATPLRHSQPRGEIGPYDQGIEGHVMYVGGGWADTKGNEVDFPHACSRSFDTKEAMDKCLADNGVAGYFTDYHPADRRIPFQLFETGIYVVLTAALLLLAYRLVKRSHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC0</accession>
    <name>A0A7W7WUC0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="11" type="ORF">F4559_001395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="503"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="512"/>
            <end position="519"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="562"/>
            <end position="566"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="616"/>
            <end position="619"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1008" mass="103766" checksum="19F86396BC597931" modified="2021-06-02" version="1">MAGKARVHELAKELGVTSKELLNKLADQGEYVKSASSTVEAPVARRLRDAYAKNESKPKPAGKPGPPPKPQAPAPQQQAETRTEAARPAAPASKPGPRPLPGPKPQGPKPVSAKPVAPVPPAHPVAPAAQAATPAPAAPQAPAKPSGPRPGPRPERQQPAAAQGGQSVVPPKPQAPKPAGPRPPRPGNNPFGVGGGAPAPRPQAPRPQPPGGDRPERGGDRPERGPKPGDPRPAGPRPGGSAGSGGPRPNPGNMPPRPNPGMMPGRPAGPRPGPGGGGRPGGPGGGGRGPGGGGGRPGGGGGGFRSGGPGGGGGGGGFRPGGPGGGGGGGGFRGGGGGGAPAGGGGGGGGFRGGGGGGRPGGGGGRGGAAGAFGRPGGPARRGRKSKRQKRQEYMDNMQAPSVGGVRLPKGSGETIRLPRGASLTDFADKINANPASLVQVLFHLGEMVTATQSVSDEILELLGSEMNYAVQVVSPEEEDRELLETFDITYGEDAGDEGDLQVRPPVVTVMGHVDHGKTRLLDTIRKAKVAEGEAGGITQHIGAYQVTTELEGVERLITFIDTPGHEAFTAMRARGANSTDIAVIVVAADDGVMPQTVEAINHAQAANAPIVVAVNKIDKEGANPAKIRQQLTEYGLVAEEYGGETMFVDISAKQAVNIDGLLEAILLTADASLDLRANPDMEAQGVAIEAHLDRGRGPVATVLVQRGTLRVGDSIVAGDAYGRVRRMVDEHGDDVTEALPSRPVQVIGLTSVPGAGDSFLVVDEDRVARQIAERRQARTRNALNAARRKRVSLEDLDAALKETSQLTLIIKGDNSGTVEALEDALMKIEVGDDVELRVIHRGVGGITEGDINLAVAGSAIVLGFNVRAEGKATELANREGVDVRYYTVIYQAIDEIEQALKGMLKPEYEEVQLGRAEIREVFKSSKVGTIAGCMVLSGEIRRNARARLLRDNNVVQENLPVSSLRRFKDDATEVREGFECGLTLGNYADLKVGDVIETFEMREKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH1</accession>
    <name>A0A7W7WUH1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16513" checksum="AA8FB8AB224A2DA6" modified="2021-06-02" version="1">MPQQLSAQDPLDHAREAERLGVDHLVGDDVRLAAVAAVTTKIGLVVAVDPDTTQPYEVARRVATLHHLSGGRAGWQVGPSEDPLRRREFIEAVRTLWNSWDAEDLPADRDTGTFVRSGAGEFAYEGALLTLSGRFVTPRPPQGHPALIEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ2</accession>
    <name>A0A7W7WUQ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="492" mass="55284" checksum="8D212DD61BCFB30B" modified="2021-06-02" version="1">MGDEVARQEFTREDRSRYRTKVRTCLDVFARMLRESRFEFDRPTAGLEIELNLVDAAGDPAMRNAEALAAIADPDFVTELGRWNLEINVAPRPLSRDGVSGFEDVVRASLDEAERKAAETGAHLVTIGILPTLQPRHLAADALSADPRYALLNEQVLAARGEDLEIAIDGVERLRLTVDSIVPEGACTSTQFHLQVPPERFADYWNAAQVLAGVQVAIGANSPFLLGKELWRETRIALFRQATDTRGDELKEQGVRPRVWFGERWITSIFDLFEENVRYFPALLPICEAEDPVRVLDSGDTPALSELRLHNGTVYRWNRPVYDVVDGRPHLRVENRTMPAGPTVVDTMANAAFYYGLVRSLAEADRPLWTQMSFSAAEDNFLAGAKEGMEAQVYWPGLGTVPATELVLRHLLPLAHDGLDRLGVDPGRRDRLLDVIEQRCLTGVNGATWQSRAFHRLYDGTGLDRPEALRRMLRTYRDLMHTNEPVHTWPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ8</accession>
    <name>A0A7W7WUQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polar amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="79"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="34148" checksum="989DC201CB1E16F3" modified="2021-06-02" version="1">MSVSAQPRLRAPDDEPGDETGTDLSRLKVVPSRHPWRWVGVVVVLVLVAMFVNGLVTNPGWDWPTFFKFFTAESILRAVVITLELTLYGTVIGFALGVVLAIMRLSRSTFLIGVSWTYIWAFRSIPLIVQLLFWFNISYLYQELHFGIPFGPTFFGVDTKDLISPMGAAVLGLALHQAAYAAEIVRSGIIAVDHGQLEAASALGIPKVHQFRRIILPQAMRSILPNAANEVISLFKGTSVVSVVAIGELFYQVQVIYGRNARVVALLMVATVWYIALTTVLSVIQHYVEKRYAKGATRDKAGWKWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT5</accession>
    <name>A0A7W7WUT5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusB</name>
        <name evidence="8" type="ORF">F4559_001953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="14993" checksum="4BDA3EF7410884B1" modified="2021-06-02" version="1">MGARSKARKRAVDVLYEADLRGVDAVTLLADRVGSADVPPVNDYTIGLVEGVTANRARIDDLISEHAEGWTLQRMPAVDRAVLRVGLYELLWAADVPDAVAIDEAVELAKGLSTDDSPRFVNGVLGRIAMIADRLRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC0</accession>
    <name>A0A7W7WVC0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="12" type="ORF">F4559_001742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="87"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="16967" checksum="F6436B1646C81202" modified="2021-06-02" version="1">MSRTARQARIVELVTRRAIRSQSELAKTLAVEGIEVTQATLSRDLDELGAVKLRGPDGGAPVYVIPEDGSPVRGIEGGTSRLVRVLGELLVSVDHSGNLAVLRTPPGAASFLASALDRAALHDIVGTIAGDDTILVVAREPLTGADLAARVSALAAGQGQTEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD5</accession>
    <name>A0A7W7WVD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding Lrp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17551" checksum="AAFAFB7FCCCA784B" modified="2021-06-02" version="1">MTARTGHSAPLDETDRRIVAELRADGRISMRSLAEKLHISRASAYSRVERLHRDGVVTGYTAVVDPERYGFGISAYVYLKISQHSWKAVRHRVLEIPEVWHAALVSGDYDLVLLVRTPDAHSLRDLVLSRLQTMPDVTSSHTVLILDEVAGHQPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE9</accession>
    <name>A0A7W7WVE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045684">
        <property type="entry name" value="DUF6191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19690">
        <property type="entry name" value="DUF6191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="11016" checksum="D5D9EA370433D269" modified="2021-06-02" version="1">MGFLVAMTIPGLAIGLVVFAVAERVWKWARRRKGHPVLSSVAMDEFTLIFQATKQQEIDHRRMSLMLRDDEEDGAPPRGPVDLDSGKVRLTVERDDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH6</accession>
    <name>A0A7W7WVH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019910">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_4879"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03564">
        <property type="entry name" value="F420_MSMEG_4879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="31854" checksum="5CE1B7FAEEEEA62A" modified="2021-06-02" version="1">MTIGTVLGAGPDSTNYVDDVVAQARLAADAGLESGWFAQIFHYDAIALAAVVGTRVPELRLGTSAVPIYGRHPLPLAAAAQTAQAATHNRFTFGIALGAKDFVEPVFGVKHERPALRLREYLTVFDTLFKTGTVDFAGETVVARTPFPAALPGAEPPSVVVAVMGPKAVRVAGELSDGIQPYLANPKALETIVADLRAGSGGADRRVIALVPIVVTDDVEGARERAAADLALYETVPSYQRVLGLGAVERAADLAVIGDEKTVADQVRRYFEAGATEVVAANTNLGGPGDQERTWRLLGSLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK3</accession>
    <name>A0A7W7WVK3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="13">DHBP synthase</shortName>
                <ecNumber evidence="13">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="13">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribBA</name>
        <name evidence="15" type="ORF">F4559_001982</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="13"/>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
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        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="14">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="13">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="13">
        <location>
            <begin position="205"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="13">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="299"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="13">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBB4964623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="45960" checksum="DDD533C4CEEAD33B" modified="2021-06-02" version="1">MTRFPDIERAIADLAAGRPVVVVDDEDRENEGDLIFAAEKATPELLAFMVRYTSGYVCVALTEEDCDRLDLPPMYHTNQDQRGTAYTVTVDAREGVSTGISAADRAHTIRLLADPASDAKHFSRPGHVVPLRARTGGVLRRPGHTEAAVDLARLAGFSPAGVLCEIVSQKDEGDMARRDELEVFAADHDLALITIAELIAYRRRVETQVVRVAEARIPTAHGVFRAVGYDSKLDGIEHVALVYGELGEGEDVLVRVHSECLTGDVFGSLRCDCGPQLDAALEAVAAQGRGVVLYMRGHEGRGIGLMHKLQAYQLQDHGADTVDANLAQGLPADARDYGTGAQILCELGIKSMRLLTNNPAKRVGLEGYGLAVLDRVPLPISPNPENLRYLRTKRDRMGHELHQLEQYEALSQGGAVVSTAEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ2</accession>
    <name>A0A7W7WVQ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase/N-acetylneuraminate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="8941" checksum="E11A036CBE6D1ABE" modified="2021-06-02" version="1">MNWTWTIARRQAGLMRLDGLHVPLVTPFTAAGALAADALEGLAHSVLDAGAAGIVALGTTGEPATLTADERARVLAVTGAVCRNAAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL6</accession>
    <name>A0A7W7WWL6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20671" checksum="1E6AEE6057962B8E" modified="2021-06-02" version="1">MTAYLARRPKRADGRRNYDNILTAARTAFDAHGTDAALEDIARNAGVAIGTLYGHFPTRETLIEASVRDSLDALRDRAEELTAHAGDDPVAALTTWFHQSVAHCSTYRGLVGFLTASTYDEGTPLHQSCVDMHGAGGALLAMAQEAGRVRADLTPTDLFTAITSAAWARESSPPGEDHSVRLIGFLIDAFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM0</accession>
    <name>A0A7W7WWM0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28862" checksum="6F50D3EF0BF2CE32" modified="2021-06-02" version="1">MRHRTSLRHFGDSPYALIWSWLLLIGLLFVDVPLLKSALGAAAPTDHWWQSWLIAAGYGVALAATTWPASVFTLRRIEHGESRHLAAAVVFWVIWAAGVIASFVFRLLHPQGTTSADQDSFQLGEQPVETGTGPDPGNAVVLTLLVLMTGAVASGIAALGEDDLQRQRRRAARRVQRLTWRTRWANRRADRHGKAMEVQKDEIVRIEGRLAIAVEQTVGLARGLKHHVRHTIAVALGDPRATTAVTHAPDAAPADTRPTEGTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV7</accession>
    <name>A0A7W7WWV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="9897" checksum="8D33F1422676268B" modified="2021-06-02" version="1">MVILPTQRRSSEVRPPVPAQTADTPAPNVDHSELTQYLPSLGDLPAAGLLAQPLDVDQERAAALRAALQGQRSDDEHLALLDRVLEALRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWW4</accession>
    <name>A0A7W7WWW4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PKD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031573581" description="PKD domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="487"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="696" mass="67720" checksum="B77E389F863D97D4" modified="2021-06-02" version="1">MRALRPRLLGLATAAAVLAGGTPAFAVDGNLPGGTSISVDVTGPAAGTVVPRGPVTVTGTAAVGTGVAVKDTALTYVVDVSGSTQNGCAGGTILSCEKSAVANLNTVAAATDSVVGAVGAVVFGSAAATVDVSPAPGDQLLTTPGADDNGNGVRDVQEAVGSAVTGGVTQFTGRSFGSGTSFVPAVQAAGTVTAAQTEAHKLVLFLSDGFASGDVTGLAGAVPANVDYLTFAVGPGSACNGGDYNASLQAIADLTGGTCTPVPDPANLPGVVPGVIASKLTELTLSVDGGAPSPVTNVTAGLPSTGPAQVSYSVDTGFLESGTHELCVTARGTDGGGAGSVADCTTVVVNDPPTVVPGGPYAGQEGGAVSLAGTVTDPDGPSLSTSWTATPLSGVDSGATCVFSAPNALNTTVTCDDDGVWTLSLSANDSLHPAVVATTTLSLTNVAPQVGISAPADGTLVPRGAPVTVTAPYSDVAAHDTHTCTVDFADGSGPVPGTVASGTCTATRSYSTVGAHNVLVTVTDDDGGAATATVKVVSYVRAEAWSLSSSGLLSVSKRPHATCPPSSDLTTQTVNILGLGSVKALHADCALDVRDGRTDAGAEVSSASLLGGAVTVSDIEVNCTADGSGLAGSSRVGTLNGQQIGTTPRTIGIPGVATVHLNQAVVGPNGQYAHYAVRVVTLLGQEIVLSGCRMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX81</accession>
    <name>A0A7W7WX81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="22001" checksum="768EB46F01A74D68" modified="2021-06-02" version="1">MSESAVVTTRPPRLARLVTEVLAPWVWVLGLPPVLGWHATHSVGSALLWGLVVGVFGSVIPMVVIVRGARKGRWDGHHVTNREGRVVPLAACGVSLTAGVAVLVLGDAPHQMLALALAMFAELVVCVLITFALPVGGSRGWKISLHAAASAATVTVLAVAYGPWVSLAGPAVVLVCWSRVALGDHTRAQVVWGAVAGAVVGGGAYVLLERVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB2</accession>
    <name>A0A7W7WXB2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NaeI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037057">
        <property type="entry name" value="DNA_rep_MutH/T2_RE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015210">
        <property type="entry name" value="NaeI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09126">
        <property type="entry name" value="NaeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NaeI" evidence="2">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="34319" checksum="CB6F7B3BCB1AB846" modified="2021-06-02" version="1">MTDDTALFALDPSEDAVPPGGGTDPGLEAVVAWFRSVPGMVATFGEVLRQSLDEVLDGQRTGRYDVDLLEKTEKTYLGTKVEIIIRHAFALDRGTRMDYRVAGHDLDSKFSVRGTWSIPTEALGHLCLLSAAVDRKGTFDVGVLRITEDVLNKGRNKDQKTTITAAARSRIVWLAERAPLPENLLLALARPDVDAIMGQGSGQQRVNELFRRVRGRLIPRTAAVTVARQADGLKRVREARRQLAPEGIVVLGHQNESPRVARSLGLPVPDKGTFVAARLVAVDPDRDDREVVVIAGRAYAVALPGEPVEPAPPVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC4</accession>
    <name>A0A7W7WXC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="532" mass="57056" checksum="C065A032E6EE230C" modified="2021-06-02" version="1">MGGDLTDDGSDAGRWGTFRVERTVLAVTRTLTSAIRLLEALPVFAGDHRVRIVFAVDRRSRNSTGVAELIRGLPAKVHSVEDVTHDDWDLVVTASEKLDLVLDRPAPMLVLPHGIGFHKRVPDADSDDTRVSGVVAPEVLRGGQVRMLVTHPDHERRLAELCPETVGRTLLGGDTSLDLLLESAPLRARYREALGLRAGQRLVLVTSTWRGQSLLGTDPGLLADLVRELPADEYRVALVAHPNVWAWEGGWELRRVADTALRSGMLLVDPTRGWHAAMVAADVVIGDHGSVSLYAAATGVPLLLGAFGDEVVAGTAMAGLGRTAPRLDRSRPLLPQLEEVLAGHRTLVAASDVFTEPGQALRLLRTHCYDALGLPEPDFPQRPGLAPDPPAALPPLHSLDVVGTAAESLVTLRRHPVAARTSGGIRHVSVDVRERDVRRFADAAVVVRTDPAGPTWPAEALDRHPGARIAGMATPDGCVLAVRGSGRFTVKSDLPDPGLLASAVYTRLVHTGLVEGTFDLRVGADTTRITVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL6</accession>
    <name>A0A7W7WXL6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032783">
        <property type="entry name" value="AraC_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12852">
        <property type="entry name" value="Cupin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="31906" checksum="931D50894B91BF62" modified="2021-06-02" version="1">MDALTDLLRGVHARSALLCRSFVTEPWAMAYTPTVKLTVTFVLDGDAWLLVENMAPLRVTAGSVGLVRGRTRFVLASDPSTPPQFDAHQDDCERWRIGTRTYGLAPEGDATVITGSYDVQDVSDRLLNALPPALVVGCDPCATSTLLSEEVAVDRPGQDIVLDRLLDLLLVFALREWFEGDSSNAPGWYHALGDDVVGPALRAVHGRPDRAWTVSELAAEAGVSRALFARRFSALVGVPPLTYLTGLRMDVAADLLAEPGATVTSVARAVGYADGFAFSTAFKRVRGVRPSVVALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR6</accession>
    <name>A0A7W7WXR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="545"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="741" mass="78344" checksum="2160DEB0B6594E68" modified="2021-06-02" version="1">MTVVFGGFVVNAAQYVVAESTALAHVAPAAFCLTVMMVLQLGFFATPTADVRNAVGYAALVVQAAVVLGPIALYGEGWTGMPGFLAGDVLLVLRPPAGWVLFALIAAANGYAQYRLTDVPLEAVYITTLTAVIGLVVYGLSRLRGLVRELADARSELAGLAVARERLRFARDLHDLLGFSLSAVTLKAELAYRLVPGRKDHARRELAEILDISRQALADVRAVASSYRELSLDDELASARSVLTAAEVVVSVRCTAGELPTRTRTVLATVVREGVTNLLRHSKAETCDIVATATADGVSIEIVNDGVRPVPEERPDGNGIRNLTARVEALGGTLTAGPGPDDTYRLHAVVPHLSEDGDQADATPDPRRGQAMAPRIGTLIATAVFTGYAVIGSVFVVVSKAEPAGQVFAEACVLASLALVLGFFSRPEARVRSPLGYALLGVLALVTYLPGLLLADPYLGLHGLLAGSLLVALRARVGLPLFFAVVVSAGVIHLLEGGGAINVTYGFLVTVNHGLVVFALSRLRSMVSDLHEARSELADLAVTGERLRFARDLHDLLGYSLSAITLKTELTQRLVDRDPGRAQQELSGILDVSRQALADVRAVATSYRELSLDEEISSARDLLTASDIAVTVRVEPVELPPDVRTVLATVLREGIANLLRHSHATRCGITLAHEDGVLVLDVVNDGVRRAGGTTRARVTAAVGGSGSGIRNLTVRVTGVGGTLCAGVEEDDVYRLRAEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB9</accession>
    <name>A0A7W7WYB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar motor switch protein FliN/FliY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="7">
        <location>
            <begin position="170"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="24328" checksum="8071B0287EA87737" modified="2021-06-02" version="1">MTSATTNPALPTTVRAAAEAALSVLPVGENVTVGLPDQNPMAVARIAGAAVTAPMTGMLAGSLVVVVNQDLVDALRAGPLGELDLVAAVAPALGAAAGALGAAAGPAREVSVAEAVELLQNGGTPVVVPLDAAGAPYAAVAVSVASARTAPAPAAAPVRTASLASGLHLLHSVEMEVTVELGRTRMAVRELLSLTTGSVIELDRLAGSPADLLVNGKLIARGEVVVVDENFGLRLTEILAPADAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD7</accession>
    <name>A0A7W7WYD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16067" checksum="84DB618F220A1CA3" modified="2021-06-02" version="1">MPTRTELGVWRSFLRAHARLTRVLEAELIAEQRLSLAAYDVLVQLAEAPRHRLRMTELADAVLLSRSGVTRLVDRLERAGLVLRERADGDGRGVVAVLTAQGVDRLRTAGGTHLTGVARHFGDVFDAAELERFGRSCAKLVDEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF3</accession>
    <name>A0A7W7WYF3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PhoH-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="46499" checksum="BA7D230341294BE8" modified="2021-06-02" version="1">MDTSVLLSDPLAISRFAEHEVVLPLVVISELEAKRNHPELGWFAREALRLLDDLRLRHGRLDSPVPIGDVGGTLRVELNHTDPEVLPAGFRTDSNDARILACSLNLAAEGHKVVLVTKDMPLRVKAGAVGLAAEEYRAHDVTLSGYSGMADVDVDQSVVDALYREGTVDPSTVDLARLAELPCHSGLRLLAGTSSALARVTPDKQIRLVRGDREAFGLHGRSAEQRVALDLLLDTEVGIVSLGGRAGTGKSALALCAGLEAVMERRQHRKVVVFRPLYAVGGQELGYLPGSETEKMQPWAQAVFDTLGALVSQDVVEEIMDRGMLEVLPLTHIRGRSLHDSYVIVDEAQSLERNVLLTVLSRLGANSRVVLTHDVAQRDNLRVGRHDGVAAVIEKLKGHPLFAHITLTRSERSPIAALVTEMLEDYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG0</accession>
    <name>A0A7W7WYG0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="4 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_005027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="13">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="12">
        <location>
            <begin position="158"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4967668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="940" mass="101941" checksum="C7AD7DFA31F3491F" modified="2021-06-02" version="1">MTETVGGTTAKNAGRNNGKRAGLSIGRVYTTAGTHPYDEVTWERRDVVMTNWRDGSINFEQRGVEFPDFWSVNATNIVTSKYFRGAVGTPQREHSVRQLIDRVVKTYTEAGTKHGYFATEADAEVFEHELTWMLLHQVFSFNSPVWFNVGTPSPQQVSACFILSVDDTMESILNWYREEGLIFKGGSGAGLNLSRIRSSKELLSSGGTASGPVSFMRGADASAGTIKSGGATRRAAKMVVLDVDHPDVEEFIETKAREEDKVRALRDAGFDMDLGGKDIVSVQYQNANNSIRVSDEFMRAYEGGDEFGLRSRQTGEVIENVDAKGLFRKLAQAAWECADPGIQYDGTINDWHTTPESGRITASNPCSEYMHLDNSSCNLASLNLMKFLTDDGSFEVEKFTKAVELIITAMDISICFADFPTPAIGDTTRAFRQLGIGYANLGALLMATGHAYDSEGGRALAATITSLMQGVAYKRSAELAGVVGAYDGYARNADSHQRVIRKHAAANDEIRTLHATDAAVLKAATKAWQECLRIGARNGWRNAQASVLAPTGTIGLMMDCDTTGIEPDLALVKFKKLVGGGSMQIVNQTVPRALAALGYAAEQVEAITEHISEHGHVVDAPGLKPEHYEVFDCAMGERSIAPMGHVRMMAAVQPFLSGAISKTVNMPETATVEEVEEIYYQGWKLGLKALAIYRDNCKVGQPLSAGKSAKAAAETKPEPVVEYRPVRKRLPKKRPSQTVSFTVGGAEGYLHAGSYPDDGLGEIFVKLGKQGSTLAGVMDAFSMSISVGLQYGIPLEFYVSKFQNLRFEPAGMTDDPDVRIATSVLDYLFRRLALDYLPYEKRSQLGIFTADERTAQVAADYGTSSDVDLEGLRTSVESTKKPEAEVAKPTTSRVGSSTELLELHLGKAADAPLCMTCGTKMRPAGSCYLCEGCGSTSGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL7</accession>
    <name>A0A7W7WYL7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phage infection (PIP) family protein YhgE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="86" mass="8800" checksum="99AF303F520F49DF" modified="2021-06-02" version="1">MASIEEVRAAIAQAVDKAGQSAAALQQAADLAKDAQALLSQATEGSDQADVDQANAQFAEVANGVDDLQKFLANGISQAENISARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM3</accession>
    <name>A0A7W7WYM3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family ferric uptake transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15492" checksum="3C70A92F080CDB7D" modified="2021-06-02" version="1">MTTSERPTAPVPGLRSTRQRTAVSRLLDTLDEFRSAQELHEELRKRGEGIGLTTVYRTLQSLADAGEVDVLRTDTGEAIYRRCSAHHHHHLVCRRCGHTVEVEGPAVEKWADRVAAENGFSEVSHTVEIFGTCADCAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX4</accession>
    <name>A0A7W7WYX4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13413" checksum="C981D80E71DFD79E" modified="2021-06-02" version="1">MTHTKIGVAARIRRPDAGASAVEECVAAGSRGRTPESGRGPAGRRSPAVHDRRPTAGLGPTDLRTADRNPAPETPWNPTGHPMTAGLRATGSNRTTHPAPATHRNLADHAGRRPVDEARVAVGFPGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ26</accession>
    <name>A0A7W7WZ26_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7567" checksum="671DA8F201EDBE0F" modified="2021-06-02" version="1">MHRTIDGALADHAVHEAKRLRFLADAAAIVAAAAPTTVEETVFGLTVTLTRAKGARAFLARVDQVLRDAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC2</accession>
    <name>A0A7W7WZC2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19806" checksum="B169E41B41F4D372" modified="2021-06-02" version="1">MLFKPYLRDTILSIAEQGLYRPLWSTDVMEELDRNLRKRGATAQQVHHLREQMGSTFPEAEVTGYADLIDVMTNDPKDRHVLAAAIRGGAEVLVTENLKDFPASSVQPYDIEIVHQDGFLLDQLDLSPHTVHRALRTQVSRYRRPPGCVGELLDILGNDGHRCGKFADECRRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X049</accession>
    <name>A0A7W7X049_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ascorbate metabolism protein UlaG (Beta-lactamase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21958" checksum="B1017BD285210EB8" modified="2021-06-02" version="1">MRFTHFGHSCVLVETADARLLFDPGTFSAGFEDLTDLDAILITHQHVDHIDADKLPGLRKANPSARLIVAGGLDDATTAEAGQVHEFGGTRVDVLDAPHEDIHPSVRMPANVGFLVDDGAFYHPGDSLYVPDQRVDVLGVPVAAPWMKLSDATDFFGAVKPRLGFPIHEKLLARTQLYYGFLSATAPEGAEFRVLPEGESVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXL1</accession>
    <name>A0A7W7SXL1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="18061" checksum="65DB306B2B185FEB" modified="2021-06-02" version="1">MTVSVIRSALDERGLDYEEPEPGRFFVTLPGTHKQRTNCWLVVGRHALLVEAFVCRRPDEAFEDVYRFLLRRNAKLYGVHYTIDQAGDIHLIGRIGLHAVTPDELDRVLGQVLEAADGDFDTLLEIGFAGAIRREWAWRVSRGESVANLQAFRHLVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH9</accession>
    <name>A0A7W7SYH9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="PTHR10801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="443" mass="50446" checksum="F9CF9428A27497CF" modified="2021-06-02" version="1">MGDHERAVAALCGQYAAIPTGAPVRLAKSTSNLFRFRADHSGGLDVARFDRVLSVDPRTRTAQVQGMTRYEDLVDATLAHGLMPLVVPQLKTITLGGAVAGLGIESSSFRNGLPHESVRSLEVLTGSGEVVVVGPEDDLFRGFPNSYGTLGYALRVELELEPVHRFVRLTHLPFGDAWSCTDALKAICDEQSFEGTRVDFIDGVVFSGQEHYLTLGTWMDEAPWTSDYTGNAVYYRSIQRRRTDYLTARDYLWRWDTDWFWCSRAFGVQHPVVRRLVPKRYLRSDVYRRLVALDRRTGFSSRVSRVTREPVIQDVEIPVDRVPEFLEFFHREVGIEPVWLCPVKLRDPAGWPLYPMDSRVLYVNVGFWSSVDLRSDELIGDRNRLIEAEVARLGGHKSLYSDSYYTPEDFHEKYNGEHYDDLKRHYDPDGRLPGLYAKCVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYJ1</accession>
    <name>A0A7W7SYJ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="907" mass="98054" checksum="8B4C0E6EEA90CD01" modified="2021-06-02" version="1">MRVNLLGPIELVSADGVPVPVGAAKRRTVLAALALDLNRVVSGDRLLSLVWDDAPPPQAKAALQGHVAQLRKVLGDGVDLVTRAPGYVLVGDRSAVDVFRFEDLVDAARDAPDEVAVGHLRAALALWRGPVLADVPGDRLREAVSARLDEARLVAVQEMGTRLHRLDRSAEAVSVLAEAVAEHPLREPLVAALVLALHGGGRQAEALDVVRRTRERLADELGVDPGPELRDAFERVLAGDRRPVESVPAQLPREHRGFVGRTDELSDLDAGHDSAIHLLVGPAGVGKTALALRWAHRVAADFPDGQLFADLRGFDETEPLDPGTALVGFLRAFGVTDAQVAADLEGRAAQFRSLLADRRVLVLLDNARSASQVRPLLPGSGRCLVLVTSRHRLDDLVATEGATALAVPTLPEDSAVDLLAALLGRQRVDDEPDAVAELTALCDRLPLALRIAGARLASRPRWTIRSLVDELRDEQHRLALLSLPEAGRGVHAALAVSYRELPEGAARLFRTLGLHPGADLDSYTAAALLDINVVTARTHLRTLAYTNLLHETTPDRYARHDLVRLFTRQLVSVESEVDTKVARLLDYYVFVGDSARTHLSDHVRPFPPPEHVPASHPALDSHAAALEWFTVEEPNLRSALDVALAGGGLRRTWQLALCLDAFHFRRGDRLDRVTLCRIGAQAARRLGDAHGEATFLLRLGSTLADLGRVEEAVDECTRAAELAGGDRDLELAASANLGYCLMADGRLDEAQRWMTTALELSREVGDERSRVGVLNNLANLSLRRHAPEEALRHATEALGLVSAVAPSKAHTATLHTVGTASQQLGRLQVALASYREGLALAERLGDRYQEALCHRGIGDVLERLDDLAGARPHWLAALIRYRDLGLADADDLAGKLDPNLTAPVRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK9</accession>
    <name>A0A7W7SYK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (UPF0303 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="UPF0303"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="entry name" value="PTHR28255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16459" checksum="E51B132275768411" modified="2021-06-02" version="1">MLEELEAQEARLVFRRFDNDTAIALGTALLTAARDRGLPIVVSVRRGQQRLFHAALPGTSADNDDWIDRKSRVVDRYGRSSLRVRETFAARGREFPLDPALYAAFGGVFPIIVENVGPVGTVGVSGLPHTEDHAFVVERLEAFLERGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYN4</accession>
    <name>A0A7W7SYN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="282"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="372" mass="40137" checksum="7146AAA9C4920B54" modified="2021-06-02" version="1">MFRTFAQVVYVSDRTRVFARARLRLVFLVAALVYGLVLAIGTSADYVEYESPDGWWPLLFAIVFGSYAILPFSTITAWRLATVSLLVFRVLLRTEPDVVGSWQWWFYLPVLLVVAATHTTRVVLLVGLLTSGTIVLAGQFSVSSSVVPTISLLMVLYLLAFALGSRGRAERRFHAERDEKAALVERARIAREMHDVVAHHMSLVVVRCETAPYRITGLPEPAVREFAELGESARSAITDMQRLLGVLRAAGHLADTAPQPGLAQIREIVPDADVPDADVPEAVALTAYRVVQEATTNARRHAPGSTVTVRVSLVGDALEVVVRNTAGGPSTGGGSGHGLIGMRERVGVHGGTVTAEPLPDGGFEVLARVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU7</accession>
    <name>A0A7W7SYU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14997" checksum="64D864864D7F8225" modified="2021-06-02" version="1">MGENFEAKRLPRNRHSDLFHSECPGRIVFDHITGRWAPLVLVKLAEGPLRFYELRDQIGRISEKVLSEKLRLLARDGLIERTVEPATPPRVSYALTDMGYSVAKPLRRLMRWVADHGDAVLAAQARHDDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX9</accession>
    <name>A0A7W7SYX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11496" checksum="8042BD88FD44D078" modified="2021-06-02" version="1">MDGRISVDARWLELYAERVDEAAAGLSEARARLRVAPPRSRSFGELGRTVRSSDAYRRAAELLDGQLDRACEVLTSAARGLHAVADHYGSQDDDAVAAIKRAGQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA1</accession>
    <name>A0A7W7SZA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglycerate dehydrogenase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="103"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32593" checksum="C5994878EEF0654F" modified="2021-06-02" version="1">MTITVLVPDDLGVRVLSEVEGVTPVRYTAGEPLPPEAVEARVLVPRFLAGVDPEAFFADLPRLEYIQLLSAGAENFVGVIPDGVVLSTCRGAHGGSTAEWVVGALLSVYRDLPAFDRSRIEGRWDYRGTETLQGKDVLVVGAGDLAVELRRRVEPFDATVTLVGRTARDGVHGFDELPDLLGRFDVVALVVPLTSETTGMVDAAFLERMRDGAILVNAARGRVVDTDALVAELVSGRLRAALDVTDPEPLPEGHPLWSAPGLFLTPHVAGSCTGTMERAYAVVAAEIARFARGEQPNNLVRGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG3</accession>
    <name>A0A7W7SZG3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000865</name>
        <name evidence="3" type="ORF">F4559_000914</name>
        <name evidence="4" type="ORF">F4559_002857</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15950" checksum="6797B2A21050AA6A" modified="2021-06-02" version="1">MSSPSDKQSRPSRDDQADPAPRPSRRVFTPDYKLAVVTEYENAPAGEKGAILRREGLYSSHIIEWTRARDAGRLTGQPAEPGAQTKPARKSAEQIELERLRRQNEKLASDLAKTRMALDIMGKAHALLEELSGSAEDDTPPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ0</accession>
    <name>A0A7W7SZJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14618" checksum="23489A9004B21084" modified="2021-06-02" version="1">MIVIPSGRHPHEILLMAVFVLAGVAGLIAPRRFSGQTLQALPHSTLLLFYGVLAAGGLLALVGVFLPGLRGPTVEMYGLTLLAVVLIGYGAAVWWAFGARGFFFALITIGIGAANVWRAAQINASIAAARRTLRALGDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN3</accession>
    <name>A0A7W7SZN3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="12700" checksum="445E6F72298B32C6" modified="2021-06-02" version="1">MSAAVLLQWASAIGGIGAVGTAVALPLTLRRMRAEVRKAETESDKVEAEVAQVLSSTALALLAPARAEIEELERRLRLATDRATALEAEVQTLRGQVTAMSREITGLREENTALRSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN8</accession>
    <name>A0A7W7SZN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25950" checksum="7244E71104080B55" modified="2021-06-02" version="1">MAKEKGGFWVGVAAAVFHPATALMARRRGTGVENIPRTGGALIVLNHVSHLDPVYDAVFVHKHGRVPRFLAKHSLWKVPVLGTVIKGAKQIPVYRGTADAQQSLRAAHEALEQGLVVVIYPEGTITRDPDGWPMASRTGVARLALDHDVPVIPAARWGTRDLYDHYRKRFRPFPRKTVVTKVGEPVDLSAYRDRPRNLALLREVTDLLMTEVKDLLADIRDEPAPEGFHAGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZW6</accession>
    <name>A0A7W7SZW6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="24997" checksum="0B6D4BE1A720562F" modified="2021-06-02" version="1">MGDGGELSWDGCVNVRDLGGLGRVRPGAVVRMEAPTRLGESGWTAVWDHGVRTVIDLRDAGERVPDRVPRPSGITTVHCPLDPVGTPFHARWSSIDNLATPLYYPAMLVEHPEPVITAVRMIADAAPGCVAFHCAGGKDRTGLVALVLLTLAEATPDEIVADYLLTYDRMKPLYDELGHPDQLSGVTKLLAARGTTIEASLTSTVASLTMPDFLLDNGLPAVELDALRARLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY1</accession>
    <name>A0A7W7SZY1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28866" checksum="C6119B9D53D50524" modified="2021-06-02" version="1">MPRFRLVEVYPVAGGWSRPWIDDPDADDFAKVSRGICDLYSTHLAEADLRHAVSALRIFVGDYVHPDTPAAGDGHAGVLSPTSTDRPEGYEHATVRVPTGFAAWPLGDRQRVVLDAVHEAALGVATLRGWEPDAFQRARKAVESADFTFTWTGPWKSSPGRRWRARCAFRSLPDGFGRLVLEVAGPEDEAVCATSSEQIAWTTMESYRRAARTLRWATAARLEVIPCVVLGFAGDKFVAELTAEAGRLRLDDVQAAAPFGSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T097</accession>
    <name>A0A7W7T097_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroimidazol reductase NimA-like FMN-containing flavoprotein (Pyridoxamine 5'-phosphate oxidase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14532" checksum="1438AE52338D4F7E" modified="2021-06-02" version="1">MYDSVGLEVLSRQECLELLGASSIGRLVFTDRALPMVHPVVFALDGESVVLRVPEGSATLVARDTIVAFEIDEIEKDLSRGWSVMAVGHVTEVDDEASLERLRALPLASRPHGRVDHYLVVELEVLTGRRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0F0</accession>
    <name>A0A7W7T0F0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4352 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030628825" description="DUF4352 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4352" evidence="4">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18662" checksum="C3240DA37E6D8FF9" modified="2021-06-02" version="1">MRAALAGLLVLAGCAAAPTPAPVPSTYPVPPQTVRPDERVPSAPTTSDGDTAFTLLGVTTGLDSVFGSHAEWPAKGAFVRIRISVVNTGRGSILLDARRQVLVDDQGGTHQVDEQAMTIRRQPDEIDLGSNVRMEFDVYYDLPRDRTPVTLRVWGGPTLTDLKDDQSTDIPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J7</accession>
    <name>A0A7W7T0J7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">F4559_001731</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="403"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="731"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBB4964372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="825" mass="87733" checksum="8C991365058BCB5D" modified="2021-06-02" version="1">MRIPVTWLVEHLEFDETPTPDRLAEAFVRIGIEVEDVHALSGVTGPLVAGRVVEIEELSGFKKPIRFCRVEVGPDQVNGIVCGATNFREGDTVVVALPGAVLPGDFTIAARKTYGRTSEGMICSARELGLGDDHAGILVLPSGTAQPGDDAVELLGLTDTVIEVAPTPDRGYAFSVRGLAREIACAFDVPFGDPGLAEVPEAEGDAWPITVEDPVACPRFVARRVTGVDPTAPTPWWMRRRLMLAGIRSISLPVDVTNYVMLELGQPLHAFDASAVRGTLVVRRAVAGEKLTTLDESVRALDPDDVVIADDSGVISLAGVMGGASTEVRDDSSDILLEAANWDPRAIARTVRRHKLPSEAAKRFERTVDPSLAPAALERAARLLHLFGEGAIKPGRTDIGTPAVPGPVSMPIDLPDRVAGVRYARGATARRLGQIGCRVEVTTGDDGTTVVTAVPPTWRSDLRQPADLVEEVLRLEGFDTIPSVLPPAPAGRGLTERQRRRRTVARALAENGFVEVKPFPFVAPTVFDALGLPADDVRRTTVSVLNPLEADKHALATTLVPGLLETVQRNLSRGARDIALYTVAQVTLPRSQQVPVPEVGVGGRPSAAQVAALLAAVPDQPVHVAGVLTGLREQNGWWGEGRPADWADAVRAARLVGEAYGVELTVVASDLAPWHPGRCAELRVGDWPVGHAGELHPKVVEALGLPKRTAAFEVDLDALPVTDHRPAPIVSAYPPVLLDVAVVVDATVPADEVTRALRGGGGALLEDIRLFDDYRGDSVGEGKRSLAYALRFRAPDRTLTVEEATAARDTAVAAAADRLGAVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L3</accession>
    <name>A0A7W7T0L3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5051 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033390">
        <property type="entry name" value="Rv2179c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16473">
        <property type="entry name" value="DUF5051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5051" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="22073" checksum="0FB3E350044FA76D" modified="2021-06-02" version="1">MRYWYDTEFLEDGRTIDLISIGIVAEDGREYYAVNEDATYGKLNRRIRRHQWLMDNVVPGLPKPHGDRILHMPDRWLFDYHAPEVKPHHRIADEVRDFLLATDSPVLWADYGAYDHVVLCQLWGPMVDLPKGLPMFTRDIQQEAARLGIGWDELPQQESGHHNALADARHCRLRWRYLDEVRSAEGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U1</accession>
    <name>A0A7W7T0U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="24282" checksum="94220ACBA6248808" modified="2021-06-02" version="1">MVEPVFLITGASRGIGAATAALAAEAGYRLVLTARDVAALAEYAPSLGTPDRVWVAPCDVRDWAQVKALVERVEGEWGRLDVAFANAGVSVDTSFATERGSSPDQWGDMVLTNVAGPAFTARAALPALTRSGGHLVLTGSAAGRGVRPGNLYSATKWAVTGLAQNIRAECVGTGVRVTLLQPGLTDTGGIPDDRRDDPKLAPEDVARAVLYAVGQPPTVDVNEIVVRPVGQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F6</accession>
    <name>A0A7W7T1F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="28677" checksum="B02743D94C55C28B" modified="2021-06-02" version="1">MTRLVGTELTLAYDERIVVEGLDVEIPDGSFTVIVGPNACGKSTVLKALARMLKPQGGTVLLDGAAISSYKSKEVARRLGLLPQSSIAPGGITVGELVARGRYPHQKLLRQWSTEDEVVTGEAMRSTGVHDLADRLVDELSGGQRQRVWLAMVLAQQTSILLLDEPTTFLDIAHQVEVLDLCADLHDTGRHTLVAVLHDLNQACRYATHLIAMKPGEGVVAQGNPADIVTAELVADVFGLPCRVITDPETETPLVVPLRRQRALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K8</accession>
    <name>A0A7W7T1K8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030971712" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="45"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="303"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="463" mass="50895" checksum="F233EA6EE20CF116" modified="2021-06-02" version="1">MTRYQGRHRFSRRTRLTAGATGLALTIGLAVAITTTGDTGTAQADGADKSLFVDITGQRRNVDVPRPGPGAATGTFTVDCGDNENGHFNPDNFIAQPGVRNGARHLHDYVGNVSTDADSTNESLDAAGTTCRNGDKSTYFWPVLRIDRADEDEEPGDPERSHVECPDVKRVLRDVPRRSRATVDKALTELRSQITEADAKLRTLDPDSAVDEVLNPLRDKRFTTLRQLSDTLAESGRRPRGLTRLAPCTVTDGDKADRATLDRDTEPDAPGKGDGKTGTDENELPGNEGEIQRPRVDLTFRGSPAGKVTAMPRFLRVLYGDAKTTTNGPKNARRSWTCTGFEDRVLLDKYPICPQGSKVKRIHDFAGCWNGKDTDSQNHRDHMAYADAQGRCPQGFMAVPQLRISLTYDIPGDVQRAAQYAVDAFPEEKHNPLSDHDDFANVMTEDIMNRLVACVNTGKRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W0</accession>
    <name>A0A7W7T1W0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="6">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="703"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="897" mass="98131" checksum="0F4915B5A6540174" modified="2021-06-02" version="1">MTAEILYGADDLTHLEGLEAVRKRPGMYIGSTDSRGVNHLFTEIVDNSTDEGVAGHAARVVVTLHADGSVQVDDDGRGIPTGVHAKSGLSGIELVLTRLHAGGKFGGSGYKTSGGLHGVGASAVNALSHRFDVVVRREGKTHEMSFAHGVPGVFDGPGPKAAFTRESGLRVTGRTRKSGTSIRYWHDARYFENGAALDVEAVRAKLRNTAFLVPGVTYVLKTPEGEETFHYPGGLSDMVDFLAPSGDKPVSGTILVTGEGVYHENAADENGVMRSKVERHAEVEIALRWGTGYERTVECFTNTIRNMHGGTHRRGYERAVLKAVQEAIGRTRGLLKPKEDPPTLEDVLEGMTAVVHVRVPEPQFTSQTKDELSTAGITRVVLGIVEKHIKAWTEDRRTKGEAKIVLQKVVDASRVRLTQKQQKDAARRKTALEGAAMPPKLVDCRTTGVLRSELFLVEGDSALGCFTGDTMVAVAPGLAMSFADLAEDWQRGVNHYGYTTNQDGRVHVVPLIEPRLTKRDAPLVRVALDNGEQVRCTPDHLFRLRDGSYRRADALVPGDSLMPLYRAFPDGGERVWLNDRAVWVPTRRLDPRAEPEDAPDGHGHPGRRPAVERLPRAVRDDRRIDTDRSGASSPDHGSPVVDEPAAPVNHSVVSVEPLAETADVYDLTVDGYHNFALEAGVFVHNSARMARVSEYQALLPLRGKILNVQKASLADTLRNVEIASIVQVLGAGTGRTFDLSSMRYGRVILMADADVDGSHIRTLLITLFAKYMRPVIEDGRLYAAMPPLHKVVTKGRNGETRFTFTQREMEQTVARLEKAGKTVVKPVPRFKGLGEMDAEELWDTTMNPATRSVRRITLLDVEAAEAALELLMGEKVEPRRAWLVESANRVDQSAIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y9</accession>
    <name>A0A7W7T1Y9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030919780" evidence="1">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10024" checksum="11AAC87F5412EB65" modified="2021-06-02" version="1">MRRILALAAASAAMITLLVPVSQASAAAYTVPRSAGAGGTASTQDFAVALARQNARNRVLAVGVDCIDWNYRTVMVERGAGPNTYIAVVEAKALCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T256</accession>
    <name>A0A7W7T256_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26888" checksum="FE262A6544D7C64F" modified="2021-06-02" version="1">MAERLAGRVAVVTGGGSGIGLATTRRLAAEGARVVVADVDAEAGRKAAAEVDGRFAHVDVTEEEQVEFLYRSTVDEYGSVDVAFNNAGISPPEDDSILTTGIEAWERVQRVNLTSVYLCCKHVIPHMLERGRGSVVNTASFVATMGAATSQISYTASKGGVLALSRELGVQFARQGVRVNALSPGPVNTPLLRELFAKDPERAARRLVHVPLGRFAEPEEIAAAVAFLASDDSSFITASNFLVDGGISGAYVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E1</accession>
    <name>A0A7W7T2E1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="41851" checksum="1E10CCA9C3123C4D" modified="2021-06-02" version="1">MSAPRQVVVGVLADEGLPERVITAVTDELPDLFAARVSGQVRWRVEHEADQVPLDEDGNIPTRMLSEQRRRDRGWDLLVLVTDLPRRAGTKPVVAGIDVEHGVAMISLPALGAVLVRRRARALLVHVVRRLASRQLGIDGDDDGPRTATRLPGALAPAGRMSGGPESSATHLALTGLRGRLRLLAGMVRDNRPWRLVPHLAGATAAAAGTAAYGIITSSFWKLADALPPLRLAAITVVTILVMTVWLTAYNHLWDRPSGTSERRKALLYNMSTATTLAIGVACMYAILFALALLAAVVLIDSGYFAQALGHPVGAGSYLKLVWLCSSVGIVAGALGSSLEDEETVRNATYGRRERQRQERNRRRREHHEAADQERATSSPSGHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2I2</accession>
    <name>A0A7W7T2I2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24262" checksum="0AE4FA49A2E1FFF0" modified="2021-06-02" version="1">MTATRFADIPALFARMTGDEKHEWAAASTLDVLWVLYDLVLDVSPSRLDDPDRDRFLLSKGHGPMAYYAVLAAKGFLEPSTLDDWTAFDSPLGQHPDRVLVPGAEIGSGSLGHGLPIGVGMAMGLRLQGRDARVFVLVGDAELDEGSNHEAIAIAGRFGLDNLVVVVVDNESGTTGWPGGVATRFEVEGWSSSTVDGRDQEGLFDSLTREHAGRPHVVVARIRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L4</accession>
    <name>A0A7W7T2L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6192" checksum="D0159CF21A84827D" modified="2021-06-02" version="1">MAGSTTDKARMRHAVDLVVRDLRARDPRTHTDWTLSAEGVIQPPPPDPRESSAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2P3</accession>
    <name>A0A7W7T2P3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8496" checksum="4D7DCFAF9EAE97F1" modified="2021-06-02" version="1">MGFDEQNGFPTTGLRADSVVIDRNVPDSRCMPFTAGWSWKIVSKPIFAAQILTADYQEVLVRSFVVGKKFRHAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G4</accession>
    <name>A0A7W7T3G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22816" checksum="B0855130F6FC09A0" modified="2021-06-02" version="1">MTVTSINPDLSTALAAAAGGPPRRYVITGGPSSGKDDLITAVHNAGIPCMVDEPGREIYRKHRERLGRHLRKEDRREYSLEVLEAFVAEYTAHVHGVRFYNRGIPDGYGWEGFFGLKPTTELEEATARYRYDAIFLLDPLDTFEDPDDIVWAKEREIRRVHELVVQGYYDAGYEPVFVAADSASARLDFICANLRLPKPSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P2</accession>
    <name>A0A7W7T3P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphomutase (TIGR03848 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022492">
        <property type="entry name" value="Phosphomutase_MSMEG4193_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03848">
        <property type="entry name" value="MSMEG_4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="23588" checksum="A8AE2060B9E335B1" modified="2021-06-02" version="1">MATVILLRHARSTANGSGVLAGRAPGVGLTDRGVEQAGELVGRLAGIPVDAVVTSPLDRCRQTLAPLLGARGLEPVVEPDLAEVDYGDWTGGALKELAQEPLWRVVQQHPSAAVFPGGEGLASVQTRAVAAIRAHDARITAEHGPRAVWVACSHGDVIKALLADALGVHLDGFQRIVVDPASVSVVRYTETRPFVLRLNDNGGDLSGVVPPEEKPSSSDAVVGGTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P4</accession>
    <name>A0A7W7T3P4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="29313" checksum="6D2EB374D6FDBB16" modified="2021-06-02" version="1">MAVVYPGQGDPRRSIPLLWREPSDKTGLTLDAILDAAIAVADEHGMAALSMRAVGERLGRTAMALYTYVPGKAELLDLMYDKVLGELPDGYDLAAGWRAALMAWAEDARAFHLRHPWMLEVSQARPVLGPNEFRMLEALVAIVRSTGLAPSRAQAVVGVVMQFVRGTAAMVTEVRRAATVTGVSDEDWWYARSGVLTEVVPDFGERFPNATWLGAEEPPPVEDDPCASYLEREAMRNFRVGLRVLLDGVEAALGGQGVEEHRNENRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P6</accession>
    <name>A0A7W7T3P6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="1">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="31897" checksum="EA2B4015D8949D0D" modified="2021-06-02" version="1">MIVLSVAVCLPLLGVRRFPLTAALLCAAVALVGTGVDAAWPGRLVAVAAFCVAAYHRPRTVPVLVGAVAWTFLFATTGSGGGGRTAPVTDLVIMGVAPVAVGYGIRAQRERAAHQARLAVAEDRARLARDMHDSVGHHLTAIRLQAAAGRRVPAAGDKALATISDLSAAALAEVRGLVDALRAEPDVEALATRLSGPDLRITTRGTTSGLPEAVGDTAFRIVQEALTNVVRHSDADRVEVELRRRRGVLVVTVSDNGSARGGVVEGGVVEGNGLRGIRERVAALAGTVHIGWSDGWRVDARLPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3X2</accession>
    <name>A0A7W7T3X2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="44" mass="4820" checksum="064D92A39D5E2CEF" modified="2021-06-02" version="1">MNVRTSPEEIEIGYDGDLDLVLTHLAASKPHDHLVEYLASCPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T416</accession>
    <name>A0A7W7T416_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21234" checksum="1EE848626E58F8CC" modified="2021-06-02" version="1">MRTLVIGGGGTIGRRLVPALRTRGHDVVVAGRTTGDVHVDLADHPTVEAMYRQVGPVDAVVAIAAHGALDDFPTLTTEALYDNTRAKLFGQIDLVLTGQHHCADGASFTLTSGIFADQAWPHVTGGAVISGALHGFALSAALELPRGMRINVVSPTMVGDSVDAFAEHFPGMRPVPMDDLVHHYLDCVEGPHTGRIVRAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T438</accession>
    <name>A0A7W7T438_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA ligase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="35617" checksum="0B287CE7902EFE56" modified="2021-06-02" version="1">MGTPPTVEFEVDGRTVRISNPDRVYFPARGETKLDLVRYYVAVGDGIVRALRDRPCMLHRFPQGVTGDKVHQKRLPGGAPSWVRTVRVHFPRYNRHADELCVGHLADVVWSVQMSTVEFHPWNSRAADTEAPDEWRIDLDPMPGCPFSRVRRVAAVVREVLAELGATGWPKTSGGKGLHVYVRIKPDWGFRDVRRAALAFAREVERRLPADVTTAWWRRDRDPEALFIDYNQNARDHTIASAYSVRGTPEAIVSTPIRWDEVEDVDPRDLTIATVPARFAELGDLHAGIDDAPFALDALLEWADRDGTDLPDLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G4</accession>
    <name>A0A7W7T4G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="7723" checksum="BE4828F3C09D2318" modified="2021-06-02" version="1">MNSVLAIPTSVCAAIGDTTPIRHEVVGDEVRIAFGRNEIDLVLSPRAAHELATRCTVALDTLTAPEPDEDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M0</accession>
    <name>A0A7W7T4M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="11241" checksum="439BBC01C913E210" modified="2021-06-02" version="1">MIRFDLAEFAAAVHRCAPRWERAGIRWTLTFGPEYDKPAAWVDCETGDSTGHLIVWTSGEAELDTADLTTGIVHPTHYDLTGPQELHTCLDELTNRLTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V5</accession>
    <name>A0A7W7T4V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="13769" checksum="8A32BCB24AF23655" modified="2021-06-02" version="1">MADLAEVTRSGPGRLLVAVYGIFALAATARSAVQLIGRFSHAPLAYLLSAFAAVVYLLATAALAGVVSRRIAYLACGVELGGVLTVGVASLVVPSAFPEATVWSGFGSGYVFIPLVLPVLGLLWLRHTGRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z7</accession>
    <name>A0A7W7T4Z7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="80" mass="9079" checksum="600273A9A922573B" modified="2021-06-02" version="1">MTRHPLRAGRPTAPGGHAQDARRPRARHRDRPDRNDGRPMSRHAVHHERTPDTERTAPDSKTRPRDTGPARAGRQPEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T503</accession>
    <name>A0A7W7T503_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13286" checksum="C7EB02B0CC0EFD66" modified="2021-06-02" version="1">MGDLRRAVVEKRREIAALKRLDDPAAVETALGSLADLYRAQGRMHRVIDCGEETVARRRSRDDHLGMVDAFDALADLMVEVGRPDSEYRYREAARRLRLRTDPLRQGASCRTRSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T584</accession>
    <name>A0A7W7T584_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16496" checksum="698A9CA881E86434" modified="2021-06-02" version="1">MTDSGGAAVADRLDVVETCTRVLWHTDHREWEALVSVFADEVSLDYTSLNGGEPVTLPPDVIAGAWSQALGGYDSTHHLLTNHLVTVTGDAAVCTASFLATHRLASVLGGSLWTLGGTYRFSLKRTAAGWRIDGMVMTAVWGDGNRDLPAQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T595</accession>
    <name>A0A7W7T595_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="9392" checksum="435142A1808F19E6" modified="2021-06-02" version="1">MDVSDHDIQPRSREPKTMLASRRNRGIHSVDDPWYDDGGNTVRPFKARRQSGKSGKRLWRRILRKVERREWLREVVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T599</accession>
    <name>A0A7W7T599_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alkaline shock family protein YloU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13624" checksum="04DCE0AB2AECC2AC" modified="2021-06-02" version="1">MTVSGADTKTRSTPEGPDPGDRGRLTIGDTAVARIAAHAAVEVGGVGGSAHRLLGVTLGAQRADGGVRVIARVTGAVVALDVRLSVGYPMPVRRTAEEVRAHLVRRVRQLTGLTASRVDITVTALRRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y7</accession>
    <name>A0A7W7T5Y7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">F4559_004552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="41549" checksum="AD043469ACB6CA15" modified="2021-06-02" version="1">MSQSKGSVFHRLYVGTGAFDIVGKRKRWYVLFGVVLLVCLASIVFRGFNLGIDFEGGTRIQLPAASASGKITTDAVKESYTKAVGKEPVTVQTVGTGDSETIQLRSETLDASQVTSLKAALNNDVKPTGGVGSISDSAVSASWGGEITTRALIALGVFFLAVAIFLALYFEFSMAIAALVAVIHDVVITAGVYSIVGFEVSPATVIGLLTILGFSLYDTVVVFDKVKENTRGLLGLTRRTYGEAANLAVNQTLMRSINTSLIALLPVIGLLAIGVGLLGVGTLKDLALVQLTGMAIGALSSIYIATPVAVDLKMRDPKYKAQANRVKARRENLAKRAAATGTTVEAAGDVVESTDDDALAAELRREKALSAAAGAPSRTTKNADARRRPTGKKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S2</accession>
    <name>A0A7W7T6S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="45085" checksum="AC31BBA3B8D85DB0" modified="2021-06-02" version="1">MSTETPAARTASPWGPALAAIVGAEFLLQLDGTVVNVALPALRADLGVDVAAATWVLNAFFLAFGGLLLPAGRLGDVLGHRRVFLLGIGLLTVASLAAGLAPTFEVLIVGRVAQGAGAAIAGPTGLALLAILFTGERQARAFGLYSTVTALGAASGMILGGLLTAVGDWRWSLLVNVPVGVLILAIAVRAVGKDDAARARSLGVPSAVLVTAALGTGVFGLVNAAERGWGQVWTVVPLVVSAVLVAVLVAVDGRAAEPLLPRRVFADRARIGGFVALVLLASVLTGFLFHTSQFLTGTLGFSPLRTGLALLPFGLALLASTQVLTRYVAKWGLRTRATVGLVLVVAAFAWLAAATGSYATAVLPQIVVLGVGVGVAIIPFNMIVLSTVDPADTGIAAGLLQTALTVGGSIGLAVLLLPAGPSAVFAWSAVIAALAVPVINILRTPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T0</accession>
    <name>A0A7W7T6T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20415" checksum="6FF6F3019C53B5DE" modified="2021-06-02" version="1">MSTGTIIGVVVVLVVIVGAAVLLKVALQRRRLRGRFGPEYERAVAGADNRMAAERELSAREREYAKLDIRPLNAATRESYARHWTRVQEQFVDDPATAVGEADRLVTDLMAERGYPTDGGHERQVALLSVAHAKTLGHYREAHDINTRHERGEASTEDLRAAMVHYRTLFEDLLGRGREEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T8</accession>
    <name>A0A7W7T6T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8279" checksum="63E679846539F013" modified="2021-06-02" version="1">MTTAGARFRRKIRIEVEVDRTRDMPDLVVLTSRRSAEASAHVEHDRRPVAGERGGEGSGADQWTHGTNLHPSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T745</accession>
    <name>A0A7W7T745_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="17593" checksum="2157779D0BC62096" modified="2021-06-02" version="1">MSTRGSTSGVVYVHSSPSAVCPHVEWAISGTLGERADLKWAAQPAAPGQLRAECAWSGDAGTGAKLASALRAWPMLRFEVTEDPSPGVDGVRYCFAPVLGLWHAKTSANGDIVVSEDQLRALAARSRGGESFAHGVDEILGAAWDDALEPFRRAGDGAPVTWLHRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T780</accession>
    <name>A0A7W7T780_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019660">
        <property type="entry name" value="Put_sensory_transdc_reg_YbjN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10722">
        <property type="entry name" value="YbjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15066" checksum="2B6A67CA13301D48" modified="2021-06-02" version="1">MTDDDAQMTAELLTSARTALELFHEVHVDDDGALSFRHGDVPCAVQAMRLAEGLTVLSLTCVVAWDLPEDRELAVSAAERAGRGLFGTLGVVHTDRGMDVTLRYAFPAEGLKPEPLSTLLMLVVSTASQLRGELLSKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Q7</accession>
    <name>A0A7W7T7Q7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="40724" checksum="69F183427D3CAC2B" modified="2021-06-02" version="1">MKEVLLLAGTRPEAVKIAPVALALADHPVLRPVIVHSGQHVGMVEQALDAFGLAPDVVVRVPRHLGSQAELLGGLVVRLDDLFGERDPAAVVVQGDTTTALGGALAAFWRGVPVAHLEAGLRTGDLAGPFPEEGTRQMIARIAALHLAPTADAASALLGEALPDSRITVTGNTVVDAVERVSAADLPARDPDLAALERVLDARGGRLVLVTVHRRESWGVPLERVLAAVRAIADRYADVHVLVPAHPNPAVRSTVRDVLGGHDRIVVTEPLDYPDLVRTLRRAAVVLTDSGGIQEEAPSFGVPVLVLRDTTERMCAVDAGCAWLVGTDTHRIVAEAAWVLDSRLRLPRGRNPFGDGAAASRVRKALERLVGVAVEGESVSSSCGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y1</accession>
    <name>A0A7W7T7Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030845190" evidence="1">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="20710" checksum="B3385419301C9190" modified="2021-06-02" version="1">MPHSHRRKRHAGPKIALAAAGVLVLLAVVQGVVSGVVGIGAFSLDLRPTTSPPVAPIADSASDVTTTPPPRVTEEAAEEARVAIGSWKRSRGLLTVEVTRVDYQDGRLSVHAVAVNASAARMELPVATVSAVDDAGGTYGASVSTSQWPASIPKSGTITGRFDFEGRPSAAAKTLDITFAGILGQLAPTGGSLTVDDVVIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T812</accession>
    <name>A0A7W7T812_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19601" checksum="CC1244E4F70F3FEB" modified="2021-06-02" version="1">MDIRTTTALLAAGVTRYMLDLRCRPGGPWQRLLPGVVLLAGGPPTRDQLVRAALLYVGVGAALTGVDALRVHGLDLPPPDRVHVLQPAGRRRAGNHRVLVERTTRLPLATVACPVRAAVDAARHDPDPLHQHYLLAKVVDAGLATVTELRTELEAGPRRGTAVPRAALRSLSTRPDLRAMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A9</accession>
    <name>A0A7W7T8A9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="39075" checksum="8E45348899D314A2" modified="2021-06-02" version="1">MRAYLGEHRHVLTLKATAEYPDIPKVAGTSLLTDPLWTPSAPIPLADIGLQHQTGHDFHGVDGTEGFAVAHLPDDTQGHHYRSYSAAMADLAAPSVFQNRSTYRLLDADLTTSTGRLLFGSGTYFDGIDVGEASAHEFAARELGLVDDLKLREAIGAPCDPARRPTNVAISTLTLRHDREAGTAQFFLHWRDPKRVGHAGGLYQVLPVGIFQASSDESWNQDNDFDLWRCMVREFSEELLGTSEEHGSDQAPIDYETWPFAAQITQELGTGVRAYYLGMGVDPLTLATDMLTVAVVDAPLFDTLFGNIVETNDEGRILKAQRFTEDTVGRFAHKEPTQAAGAALLALAWSHRDALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B5</accession>
    <name>A0A7W7T8B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="11968" checksum="9149201F4D483B99" modified="2021-06-02" version="1">MKSDALRGHLDALLLAVLDGGPLHGYAIIEALQARSGGALDLPTGTVYPALRRLETAGLVVSDWSTVGGRRRRTYKLTRTGQKALAAERTAWREFTTAIEGVLGGGPWPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D2</accession>
    <name>A0A7W7T8D2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7436" checksum="21A152D199BAD05C" modified="2021-06-02" version="1">MIDRPGRSAGRWGSWSRMAVGTWRSSIFGSADARVPAVHLGRRAPDLHHHKARTPPSLPRTPPDTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I7</accession>
    <name>A0A7W7T8I7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="1">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="24203" checksum="3B8BBB55E856DB69" modified="2021-06-02" version="1">MLLTRLERFNRRHPWSHNDHYGPWVARRVAASGARHVLDVGCGTGNLVARLRHRATTVTGLEPDPATARVAAERFAGRSGITVERADFAARDRQRRWDAITLVAVLHHLPLEPTLRELRDSLTPGGRLVVVGCYRDDRSPRLLVDLPAVLANPVVGLLRHPACADAPPPHMTAPTAVASETLAEIRAAAGRELPGARIRRRLFWRYTLVYDAPPGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8U1</accession>
    <name>A0A7W7T8U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21413" checksum="457A18205BB90D4A" modified="2021-06-02" version="1">MTSTAHRPPTPRQVELLGRLEALVLAEGFAHFTLDNLAARLRCSKSTLYALAASKEQLAVRVVGRYFKGAAERIERKIAGIEDIRVRIGTYLAGAAEELRKASAKFIADVSAFAPTRTTYERNARAAAQRIREFIQEGVHSGVFREVHASLIAEMVGLLIESIQTGVLTRRAAVADSEAFTALGELLLDGLHRSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T930</accession>
    <name>A0A7W7T930_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ORF">F4559_006201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="23656" checksum="BA0ED70DD27A0A8F" modified="2021-06-02" version="1">MGVVALVPAAGRGERLGYGMPKALVPVGGVPLLVRAVRGLFESGRVGHVVIAAPPADVDAVHTVTAPLAPAFGAVRVLAGGAERSDSVRIALAHALREIPDTTVVLVHDAARAFTPPHVVKAVVDAVEAGHEAVVPVLPVADTVKEVDDAGVVTSTPDRARLRVVQTPQGFAAGTLRRAHESGLHATDDAGLVERLGVRVVTVPGHQDAMKITTPFDLAVAEALFVGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T969</accession>
    <name>A0A7W7T969_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_006223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030617884" description="Aminopeptidase N" evidence="12">
        <location>
            <begin position="29"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="14">
        <location>
            <begin position="73"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="331"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4968864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="488" mass="53018" checksum="CE0D98DA7B7E3008" modified="2021-06-02" version="1">MAVSRKTRPALAVVAVLALVTVGVVVWRIPSSDESRPAAATTTTAAPATGLPGADGAGDPYYPTDGNAGYDVERYDVTVEYDPETKRLDGRTRVTATATADLTGFNLDLYRLTVSEVEVADTAARFRQEGDHELVVTPAAPIPTGTRFTVEVAYGGEPGLFPEKALGSNGWQISASGGAFAAGEPHSATTWFPANDTPRDKASFHLVATVPEGWSVVSNGRLGETTTAAGRTTVRWDAETPMATYLTTIAIDRWRIEKSTANGVEIVHAYAPGAEKRTELGERLPEVLEFLAGKFGPYPFDAAGGIFLSDRIGFSLETQTRPIYAAWADLDTVVHENAHQWFGDSVTVDTWADICLNECFASYASWLWDEAKNGADLDAAYRADVEKRSDKSWKHKLYDMGAGNEFKAVYDKGPLALHALRRYVGDDAFDRILKGWVAKHTGGNASWPEFEKYAAETAGRDLDGFFAAWFRGDGVPADEYLWPGPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA33</accession>
    <name>A0A7W7TA33_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent monooxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">TetX monooxygenase</fullName>
            <shortName evidence="1">TetX</shortName>
            <ecNumber evidence="1">1.14.13.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An FAD-requiring monooxygenase active on some tetracycline antibiotic derivatives, which leads to their inactivation. Hydroxylates carbon 11a of tetracycline and some analogs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a tetracycline + H(+) + NADPH + O2 = an 11a-hydroxytetracycline + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:144644"/>
            <dbReference type="ChEBI" id="CHEBI:144645"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of an N-terminal FAD-binding domain with a Rossman fold and a C-terminal substrate-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aromatic-ring hydroxylase family. TetX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00845">
        <property type="entry name" value="TetX_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043683">
        <property type="entry name" value="TetX_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="40489" checksum="04DBF93F496E9E79" modified="2021-06-02" version="1">MNTVYRDKVIAIVGAGLGGLTLARVLHVNGIEAVVYERESARDARDQGSMLDIHSGQRALREAGLIDGFHAVARGAGQDMRLLEPDGTLLLQEDTPDDAPLLRPEVDRADLRGLLLDSLPEHTVRWGHAFESAAAGEVRFADGGRATYDLLVGADGANSRVRALLTDTRPAHLGHNGVELRIPDVERTHPDLAAMVGRGNLWVLGDGKSLAAQRNGDGSVRVGVSFYNTDEHWFTGSGIPFDDPAAARARLIELLAGWHPRFIALIAACDDMIVPRSLAALPVGFTWPSAPDVTLLGDAAHLMPPVGEGANMALLDGARLALALVAHPDDFPAAIAEYEREMFERTAAAARMSARMQDLLMSPDAAQRMLEFFRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA59</accession>
    <name>A0A7W7TA59_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="32599" checksum="2D407980BF24F3DF" modified="2021-06-02" version="1">MIEATGLTKRYGKTVAVDDLSFTVAPGRVTGFLGPNGAGKSTTMRMILGLDRPTAGRVLIDGRDYRDLHRPLVEIGALLDAKWVHPNRSGHAHLRWLARSNGLPARRVDEVLDLVGLTGPAKRRAGGYSLGMQQRLGIAGALLGDPKILLFDEPVNGLDPEGILWIRRLLHRLADEGRTVFVSSHLLSEMAQTAHELVVIGKGRLIAQTSTEQVIRDATEDTVRVRSPHVDRLLPLLTGESARVVELDGAVVVHGLQAGRIGELAASNGITLHELSPQRGSLEEAFMRLTRESVEYHAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA80</accession>
    <name>A0A7W7TA80_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rbsK</name>
        <name evidence="14" type="ORF">F4559_006685</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="13">
        <location>
            <begin position="3"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="200"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4969326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="29838" checksum="234BEDE7AF9ABCEC" modified="2021-06-02" version="1">MTILVLGSANADLVVTVPHRPRAGETVLGGDVRTLPGGKGANTAVAAARLGARVVFAGAVGRDGHGELLRTSLADAGVDTAHLRTSDRPTGTAHITVTPDGENSIVVSPGANADLRESDIDALPWQDVATLVCSLEIPVPVVCHAIRTAAGHGVRAVLNLSPVTDLPDDVLPLLDPLVVNEQEAEALGTSVDVPRATVITLGADGARLGDRRFPASRVRAVDTTGAGDAFTGALVRELDQGVTLPEAVGFAIRAAAWSVTREGAQPSYPDLADLSGERGRPAVRRPGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA99</accession>
    <name>A0A7W7TA99_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11938" checksum="51C2072F4BFCD19A" modified="2021-06-02" version="1">MPDVKLEIQMLHDRIMVRISPEDGERRSSGGIVIPATAQMARRLAWGDVHGVGTSVRHVKVGDRVLFNPEDQFEVEVQGQTYLVMRERDVHATATERTDHGTGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TC51</accession>
    <name>A0A7W7TC51_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="43674" checksum="C4E161CE5D51FEC0" modified="2021-06-02" version="1">MSDGYKVPLAQPTPFPHAGRVPPAGAAPIDGATAVHSVGSLPYSADPSPTVTLGSGFSGGPGFVPVPVSHVESAPTQTVQIQPPPDATVVVTPPQTPDATVTFTPPSDATVTITPSDLPQAGQPGTPADPGTPAVDPTLPATPDAGAPTSGAPLPGTPQAPQNGSPQNGTPQNDVPQNDVPPQTGTPQNGTPQDQAPQPPTPGSQPTQPSTPDGQAPAPSDPDSTKPGQPTDPGASKPDAGGTNPDTTPGGPVLGDPKPGDPKPGDPAPGDSTPDRSKPDPDGSKPDDKSGRDDTGQEKPGDTGPKVPPNSGGEAQPGNVESPKPDHVVVDRAEFDTMLKVIAEAVGKVESVRKDAIPQLDVQLQFGNNWVGHTISKRLHAVAVGDDQSALSVIARFSNVLSEVQQSIERAAATLGQADDDTADEIRRAGGGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TC66</accession>
    <name>A0A7W7TC66_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="36" mass="3827" checksum="8F35856B79715F78" modified="2021-06-02" version="1">MGEFDVSGAHLGLGSAEPTPRVSGKRNERQGERDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCN6</accession>
    <name>A0A7W7TCN6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tdh</name>
        <name evidence="9" type="ORF">F4559_006689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00692">
        <property type="entry name" value="tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="8">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="344" mass="36691" checksum="D920D6E9AB8EB581" modified="2021-06-02" version="1">MKALVKSEAGPGLTLTDVPEPVPGPGDVVVRVLRAGICGTDLHIESWDDWAASTVKAPLTLGHEFAGEVVEVGPAVTGVRVGDLVSGEGHLVCGTCRNCKAGRRHLCANTRGLGVHSDGAFAEYVVLPEQNAWVHRKDLDPDVAAIFDPFGNAVHTALSFPVIGEDVLVTGAGPIGIMAAAVARHAGARNVVITDISEHRLELARKVGVDVALDVSRHSIEEAQKQLGMTEGFDIGMEMSGQPVALRDMIRNMAHGGRIAMLGLPAEPFAVDFGAVVLKMLHLKGIYGREMFETWYSMSVLLQRGLDLTPVITHRFGYTAYEEAFATAREGKCGKVILDWTTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCQ6</accession>
    <name>A0A7W7TCQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
            <ecNumber evidence="3">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017815">
        <property type="entry name" value="Myo-inos-1-P_Synthase_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03450">
        <property type="entry name" value="mycothiol_INO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="195"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="39633" checksum="0C79FA234FD22C0D" modified="2021-06-02" version="1">MGDNRRTVRVAIVGVGNCAASLVQGVHYYRDADPATPVPGLMHVEFGEYHVRDIEFVAAFDVDAKKVGTDLSDAIGASENNTIKIADVPSLGVTVQRGHTFDGLGRFYRETIEESHEQPVDVVAALRDAEADVLVSYLPVGSEEADRFYAQAAIDAGVAFVNALPVFIASDPVWAEKFRAAGVPIVGDDIKSQVGATITHRVLAKLFEDRGVRLDRTMQLNVGGNMDFLNMKELERLESKKVSKTQAVTSQVDRDLGARNVHIGPSDYVAWLDDRKWAYVRLEGRAFGDVPLNLEYKLEVWDSPNSAGIIIDAVRAAKIALDRGIGGPILSASSYFMKSPPVQYSDSEAHEAVEAFIRGDVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT09</accession>
    <name>A0A7W7WT09_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="120" mass="13193" checksum="AB8EDA31A2CFE44D" modified="2021-06-02" version="1">MDKSIDEAVADIGDYIRRQRNTAKISLRQLAKLAGVSNPYLSQIERGLRKPSAEILKQIAKGLRISAEALYVEAGILQERAGGALADAIVAAPDLTERQKQVLLDVYESFRRENTAGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTD5</accession>
    <name>A0A7W7WTD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="2"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9625" checksum="90C90E79BEBA1E70" modified="2021-06-02" version="1">MWRKSSYSTDQANCVEVMWQKSSHSTSQANCVEVMWQKSSHSEPENCVEVARSADRVSIRDSKNPDGPVLTVPAVDWRGFIRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM0</accession>
    <name>A0A7W7WTM0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">F4559_000226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13572" checksum="CBD69A07CB6ECB2F" modified="2021-06-02" version="1">MAKLSTEELLDAFKEMTLLELSAFVKQFEETFEVTAAAPVAVAAVAGTGATAAPAEEEKDEFTVVLESAGDKKIQVIKVVREVVSGLGLKEAKELVESAPKPLLENVAKDVADAAKEKLEAAGAKISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP2</accession>
    <name>A0A7W7WTP2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="181"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="42404" checksum="2F34477DD7CB1BD5" modified="2021-06-02" version="1">MPRPPLPIGTFGSIRHYPTATGWRAMTMYRDRDGKTRPVERLGKTKTAAERNLKKALAERSGPSMGDALTADSRFKKAAELWFGKFEAAANAGSRSLGSVDTYRSILDRHVLPGLGEIRLREATVPRVDAFLDALRRNVGVSTAKTARSVVSGVLGLAVRHGALDVNPTRETARLEKGRKKGPRAFTLEERTLFLKRLDADEKAKARDLPDLSRFMMATGVRIGEALAVYWGDVDPDARTVAVDHTVIRAKGVGLFRKSTKSEAGERTLLLPSWAVEMLEQRKAITLYPCGPVFPDSLGGLRDPSNTRRSFREARGAEFAWVTSHVFRKTAATILDEAGLTARVVADQLGHSRPSMTQDVYLGRKVVDRRAADALEGAFGQPPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP5</accession>
    <name>A0A7W7WTP5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chitinase</fullName>
            <ecNumber evidence="11">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_000693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018366">
        <property type="entry name" value="CBM2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00561">
        <property type="entry name" value="CBM2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031279111" evidence="8">
        <location>
            <begin position="31"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="9">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="186"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="555" mass="58188" checksum="AD6734CC414B41F1" modified="2021-06-02" version="1">MSKTRWHLTALFVAAATAAVGLVVAPSASGAGGVSATFTKGSDWGSGYEGKYTIKNGSTSALTSWTVEFDLPTGHKVASVWDGTQTTSGQHVTVKNTWNGNIGAGASVSFGFNVQYSGGFTAPQNCKLNNASCDAGGNPTTSTTTTTTTTTTTTKPTSTTTTPPITTDPTAPTTTTTTGTPPPPGQKNLGYFTQWGVYGRQYFVKNIVTSGSAAKLTHINYAFGNVQGGKCTIGDAYADYDMAYTTANSVDGVADTWDNGALRGNFNQLRKLKKMYPHIKVLFSFGGWTWSGGFGQAAQNPAAFAESCYQLVEDPRWADVFDGIDLDWEYPNACGLTCDTTGFSSLKTLTSAVRTRFGANNLVTAAITADASNGGKLDLADYGGTAQYLDWYNVMTYDFFGAWAAKGPTAPHSPLTAYEGIPQQGFNTDEALQKLKSKGVPASKLLIGIGFYGRGWTGVTQATPGGTATGAAPGTYEAGIEDYKVLKTKCPSTGTIAGTAYAFCGGNWWSYDTPATIGGKMTYAKQQGLGGAFFWSLDGDTTNGELVTAISNGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR6</accession>
    <name>A0A7W7WTR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17875" checksum="E9AF4DC32DE924DB" modified="2021-06-02" version="1">MPIVLHRTAEVFVDASTVDLVGESLVAEFEPDWNLNGLAESDPDGEGVRIICGQETGVVDVTCELWDQPAPLQAASWQDIAEISAHWTSSYLDFGTTTQDDPACRLPLPAAGSYRVRVHGTHRDGDDPRPDSAPRETYLVQLWAAPPDGPTSLKSTSAFAASWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU89</accession>
    <name>A0A7W7WU89_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulatory protein P-II 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12101" checksum="302CB47E0437A9BF" modified="2021-06-02" version="1">MKLVTAIVKPFTLDDVKTALEQLGVLGMTVSEVQGYGRQKGHTEVYRGAEYAVDFVPKLRVEVLVDDSAVDKVIDAVVDAARTGKIGDGKVWVTPVDTVVRVRTGERGTDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUB8</accession>
    <name>A0A7W7WUB8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031348093" evidence="1">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16362" checksum="9DFFB2303BC95513" modified="2021-06-02" version="1">MSVTTLRTAFATVFATATTAVTLMVTALPAAAAIDAPAVTDDYLFNRSLADFSGLRTGAPNADQLDWSSDGCSWSPDNPFGFKFLPACHRHDFGYRNYKRQARFTEASRLRIDDRFKADMYQQCGSNWACKRTADLYYKAVREFGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG9</accession>
    <name>A0A7W7WUG9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="33059" checksum="4D7A7BBFCE591DE2" modified="2021-06-02" version="1">MDAATQLGLHELAVEDAITAHQRPKLERYGDTRFVVLRSASYRDDTERVEFGELHLFVGPNFVLTVRHSDTPDLAGVRQRLENQPHLLRLGPEAVLYAVLDAVVDGYPPVVSGLHNDIEEIETQVFSRDPNASRRIYELSREVMEFQRATHPLLTILDNLSAGFAEHGVDEELQRHLRDVADHVIIVVEQVTSFRGVLADILAVNTTLVTQAQNEEMQRLAEASNAQNEQIKRISSWAAILFAPTLIGTIYGMNFRHMPELNWMWGYPFALLLMALVCTGLYFVFRRRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUI5</accession>
    <name>A0A7W7WUI5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="33485" checksum="2C2A1451FCDC42BB" modified="2021-06-02" version="1">MSDFLDQFLPSTVGGLVFGSIYALVALGYTMVYGVLRLINFAHSEIFMIGTFASLVVVTAVAPDVPLTGIALVGVLLLMMLVSGAVSGGAAVLLELVAYRPLRRKGATRLTALISAIGASLFLQELFALVVIPAITGNPGRNQQSIPRVAARDVLFQIGNADVRLDQVIVVVAAVIMMVALDRVVNRTRIGRGIRATAQDPEAAVLMGVSIDNIVRTTFLLGGAMAGIAGALYLMEFENTVFNIGFVLGIKAFTAAVLGGIGNLRGALLGGVALGLIENWGAIFLGSEWKDVIAFTVLVVVLMFRPTGILGESLQKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUI7</accession>
    <name>A0A7W7WUI7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone HtpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="586" mass="64476" checksum="0EE7E1FFB6358247" modified="2021-06-02" version="1">MAHTFGVDLRGMIDLLSHHLYSSPRVYARELLQNAVDAITARRALQPDAPGEVVVEPVEPGGNGTFRISDTGIGLTEREVHDLLSTLGRTSKRDDLGFARRGFLGQFGVGLLSAFLVAERIRLVSRSAKGGPAVRWSADSAGNYEVEVDDDARVEVGTTIELVPHRDSEHWLEHDVVRALVVEYGELLPVGVVVGGERVTSGELPWQGGEDLLAYGARVLGVEPFDAIPVEVPAVGLTGVAYVLPRGVHPGARQSHRVYLKRMLVGEAIEGLLPEWAYFVRCVVDSTSLRPTASREALYQDETLLAVREELGRQVRDWLVRLDATDPDRTSALLDAHHLGIKSLARVDDEMLRLVERWLPYETTEGGQTLKQFKRKHGTVLFLPDVDEFRQLAPVAHAQGMGLVNAGYAYDLEIMERLVALDGPFAARRVAPTEVLAALGDPEPDVERALRERLVLAKDVLGRHDCEAVPRDFDPGSLPALLMTNVEGERRRDAKQASEEADPLWADLLGSLVADDSGAAQRLVLNCRNPLVRKLATLTDQALVELTVESLYVHAVLQSRRPMRPRDTAALNNSFLELLDRAVGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP2</accession>
    <name>A0A7W7WUP2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="149"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33028" checksum="103ECF724BD26C83" modified="2021-06-02" version="1">MTVGRGLVDALVAAQGTRLSTLDPLVPPVSDPPDGDVVTAALPDGSRVAGVLRHQVHERMSAARLWSATEVWELTPLLGGAGAAGMDALLRAWRRRLDALRPAATDSACVLTWPSRDVEATGVLLDHGFVPLTVVAVRRAAPPPEPPGVTVRAAGPDDLDTVLALALAELRYSAQVGSTVLRPEAAEVKRRALAERLAAGGPAWLAERDGIAVGLAECSLVTSEPGNWAATRLPTGRWGYVNCVSVPPGARGTGVGRRLMAHAHRELARLGTVGTYLYYNPPNPLSSVFWPRQGYRPLWTVWEVRPAGALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU4</accession>
    <name>A0A7W7WUU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="21773" checksum="2C5BE904805D2A48" modified="2021-06-02" version="1">MFTGIVEELGEIVAVEDLPDAARVTIAGPVVTGDAKHGDSIAVNGVCLTVVDVVDGAFTADVMRETLVRSSLDGIAAGDRVNLERAAAVGQRLGGHIVQGHVDGTGVVRSREKAEHWEIVHIGLPPGLARYVVEKGSITVDGVSLTVVEVTEDSFTVSLIPTTLDLTTLGRRTPGERVNLEVDVLAKYVERLALPHLRAAGEEGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW4</accession>
    <name>A0A7W7WUW4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dGTPase</fullName>
            <ecNumber evidence="3">3.1.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.5.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020779">
        <property type="entry name" value="dNTPase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF32">
        <property type="entry name" value="PTHR11373:SF32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="65"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="523" mass="56529" checksum="931B7A7E6799946A" modified="2021-06-02" version="1">MQHEHTDPRAARRSGGDSGSSLSDLAAGPFRVDRDRVAGSPFFARLGGVTQVVSSTGSGLLVHNRLTHSLKVAQAARAIAERIGSRPDLAGVLDKLGGCDPDVVEAASLAHDLGHPPFGHLGEQVLDRLARHRFGLADGFEGNAQSFRIVTTTDVRGPASLGLDLTVAVRAAMLKYPWTRRSHPRPHPKDLAEPPRGAAEPPDAPGTGAVKFSAYVTELPDVLSSRAYYDGRIESWQQTVEASVMDTADDIAYAIHDLEDFHRVGVLQHATVAAELGTWLSDALNLAGLDRSLLAAQSRLPGRSLEALRRRLHAKDSWAVDDEAFAIAVAKVRSELVDGLLAVPFDGSVEAERAVAGFSARWTRRLVDAVRVVEEPTTRSGHVVLAVAQWHEVQVLKFVHRRFVLLRPDLALHQRGQARLLTALVEALEQWVTDRHEADRLPRRLHDLVELAGAEYATLARTDPRVLVGATGETPSGPDAVRALARGRAIVDFVASLTDNQASALLEGLSGRTGQLWTDAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX5</accession>
    <name>A0A7W7WUX5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="PTHR33973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="26924" checksum="AD9E7641ACAEF9DC" modified="2021-06-02" version="1">MTPALYEVEIGHTRRERLDRSFRHRSYLWLVDLDDLPRLPRPLRPFARFRARDHVGDPARSIRANVDAYLAGQGIDLRGGRVLMLANARLLGYVFNPLTLYWCHDPEGRQVCVIAEVHNTYGERHVYLLHPDEAGRATVAKDFYVSPFLALSGQYAMRVPKPSGTLSVTIALRQDGRTPFSATMKGHRLPVTTRGLVRLLVRRPLSTYRVSWLIRRHGIALWARRVPIVPRSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA1</accession>
    <name>A0A7W7WVA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-beta hydrolase superfamily lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22471" checksum="7D6EE079A51B7DB2" modified="2021-06-02" version="1">MEPAVDVLPPTGPVRAVVLVLHGGRVRGYGGVPRYRLAYLRMGPFARAAHGLGGVAVWRLRYRYRGWNEPHRHPVADARWALARIAREHPGVPVVLVGHSMGGRTALYVATEPNVVAVCALAPWLEPGDPVRLGGRTVLIAHGDRDRTTDPAASHAYALRTGAGFVRVVGDGHAMLRRAALWTRLVRDFTAGAIGVEPPRVDHANHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK9</accession>
    <name>A0A7W7WVK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RsbT co-antagonist protein RsbR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025751">
        <property type="entry name" value="RsbRD_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14361">
        <property type="entry name" value="RsbRD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="154"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30714" checksum="8F68BB2756792AA7" modified="2021-06-02" version="1">MVSDNRLTGLLTGHRDVIVQRWVEAVAVTTRGRATSAELDRDFREFYGALLGALEAGGRDVAGEGYGELRSLLAEMSRARARAGYTPSETASSVFALKKVVFEITGHDEDPELFRQLMVFSELLDSLGLVTFETWAKAREEIIQEQSEQLLELTTPVVKLWEGVLAVPLVGTLDSARTQVVMEKLLEALVETGSEHAIIDITGVLAVDTQVAQHLLKTVVAARLMGAECTISGIRPQIAQTIVELGIEFGDIATKASLADALRHALRRAGTEFVRSADRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL6</accession>
    <name>A0A7W7WVL6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="2">
        <location>
            <begin position="67"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19041" checksum="A72D762C5A5045B6" modified="2021-06-02" version="1">MRGLSRKRVTWVVLGFVVVAVIVGLWAFQPWRVWTRSEVDEALPTDFAVTTTTGPVTGASIPTAAPAVLATGEFVTQEHETHGTASVLRNGDTRILRLEGFSTSDGPDVHIWLSDATAGGDWGKYDDGRYLPLGPMKATDGNQNYTIPADADLTGLHSVVVWCDRFNVAFGSAPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT2</accession>
    <name>A0A7W7WVT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="11776" checksum="1892CA308CD04078" modified="2021-06-02" version="1">MGSGPQCAGEHPDRFAVVDLDDDSSLAEASAVDGPRLAMRAGTPWVRRLGRVEPRDAVDPRWTAGTVLITGGTGGLGGLLARTSSARTACGAWSWRVGAARRHRVPPGWSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT8</accession>
    <name>A0A7W7WVT8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="37" mass="3988" checksum="0F683B5DE87F70CC" modified="2021-06-02" version="1">MEVANGLRAVRDSKNPDEAVWFPPAALSRFLSAVKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW0</accession>
    <name>A0A7W7WVW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="29380" checksum="4CB17E81695464E4" modified="2021-06-02" version="1">MRRQEFSYLLVPEIPALPPKPSGLPILFHVPSGVTKGRKFRTTWISYRALVEVHHYLDLTRPLAVEGSTWRPPPRAGEPLLVAEVDPVAGRVNGKRVRWASLRPAERLRLVAPDGGSMLVAVRGDGGPFTAWATVFERVSDRIRDRFEPRFPMVYPHRLRHTFAIRTLEMLVEGYYAQAAKLVKDTDGDAALALYPSKADPLMVLRGLLGHSSVLTTEAYLRRLDMTRIYRNAYERAGQEHGLAEITAAEREADAEFQDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW5</accession>
    <name>A0A7W7WVW5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8680" checksum="269AEAFE16B9371F" modified="2021-06-02" version="1">MVTGRPGEFSPDVLDVLLAASPDGITEKHLRDFFQEVATAVGAPLTADEVSSIVADVLTETDLRAVGASVGRAARALFAPKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW52</accession>
    <name>A0A7W7WW52_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16486" checksum="BBCD80C486ADF7A0" modified="2021-06-02" version="1">MTTQRDLDRADWHRLHALHDRVEAALERSLQRRFRFGLSEFGALCALAASPTGELRMQDLTDTVGLNQSSVSRLVARLEQAGLCTRVLCETDRRGVYTVITDEGRRVHDQAAPVHDDTLAEIYLKLTEDPDLGPVLDAVRSASTTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX43</accession>
    <name>A0A7W7WX43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8103" checksum="55957C7BB528E247" modified="2021-06-02" version="1">MFNNAPGESPMVLARLFARLFGAAATTKPGPEGFPYSGYLVPAHTWTSTSDAPELSAADLDVVYKKLSDADDRGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXI1</accession>
    <name>A0A7W7WXI1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-arabinose 1-dehydrogenase-like Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="194"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="38304" checksum="8854C83F28B06548" modified="2021-06-02" version="1">MTVPTSTRAAVLTEHGKPLTLTELPLPSEIEPGAALVRVSCATLCGTDVEIWSGKMSFPGMLPMVLGHEMVGEVVAVGEGTRDALGRDVTVGSRIGWSESTCGECYGCVILREPVACSRRGYGFLQRSDVHPYATAGLCEYAYVVPRSAKLLLPEALPDTWTAMAGCAAKTVLRAFSYVGGLTGKKVVVQGSGALGVFATAVAHISGAAQVITVGAPESRLTLAREFGASDTVDIALGSDGIVERVREVTGGHGADLVLDFAGAPTVGVEAVNMAAQRGHVVIVGSTGPVGAPLALGTIMGKELTVHGSLNGDISDYHKAIEFFSAFTDRMPWNDLFGSPVGLSAASERIEAMHRLDEVKAVIDPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM0</accession>
    <name>A0A7W7WXM0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="23386" checksum="83939D7B20CCFDF3" modified="2021-06-02" version="1">MFGRRRKRGRHSANRGTAQPEVEVGLDDDRPEHGPFDEADTPDDGLNRLDLGSIRFPVPEGAQLQVEMDPAGAVRAVHLLTTLGQLTVSAFAAPRTEKLWPEVGAELITQLKGDGFRINRENGEWGEEISARNNEVHLRFVGVDGPRWMVRGVAAAPSEDQADHALVALREVLRLTVVVRGEQPMPVRTPLPVELPDAIARHIQAQQQQQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXU2</accession>
    <name>A0A7W7WXU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator YbjK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20505" checksum="537ADE79FA236285" modified="2021-06-02" version="1">MTDRRTLLADAAIHVIAARGMRGLTHRAVDAEAGVPEGSTSAYFRTRKALVEAVVHRLSELDQVEMADVLTAEFDLDRFALLVATVLDGWLGPARTRTLARYACLLEATHHEELRGILAHGEKPRAQTVAILRAAGVPSPEAAGHTLVAFLEGLLFDRLVGAGATTSPPPGTPESVASLTKAVRMGLRAVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY57</accession>
    <name>A0A7W7WY57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14269" checksum="4A7CEE70C6F909A8" modified="2021-06-02" version="1">MTAGVRGEHVHSPDRDAPRPAPPPSVRTLSAAGELLRALAAPVRIAIVLQLRSADLCVHELVEILGVAQPLISQHLRVLKAAGVVHGERHGREVVYRLVDEHLAHIVVDAVTHVEEGPHGSNERTRRTEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL8</accession>
    <name>A0A7W7WYL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="12187" checksum="2D7CD94EADDE64DD" modified="2021-06-02" version="1">MPSCLSHNAFMAESSLKLNARTNNSRSSADAEGSTSTATSSFLNDAVGKGSALRLPAVAPVSRSNTDTARSPSDDAATAAAIAVGRSGAVTVALDGLVVPEESEEAEGCEESEEIEGADAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR8</accession>
    <name>A0A7W7WYR8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="27"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="343"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="586" mass="62892" checksum="F3391303DA527239" modified="2021-06-02" version="1">MKDQRTSTAATLRRLWPYLKPVRTPVLLSMVAALLAMLCGLGTPLMTQSVVDGPIAHRDPAGLIWPIGVVLLLGLGEAALFYARRKLIAGPAADVEARMRMDLYGHLQRLPVAFHDRWQSGQLLSRATGDMSTVRRFVGFAIVFLVVNSIVVLTGLGVLFWLSPALGLIVVACTLPLVALSYLFETRFKVVARRAQDQTGDLTTVVEESVLGIRVLKAFGRGPHLAKKFLRQARDLRDTEVEKAGVFASLWAVLIILPELGIAGQLAYGAFAISDGTLTVGTLVAAITVNAYLRWPIDSIGWLLAELNQTASALERFFEVLDTPVEITSPEPAADVPAVRGHVRFEDVRFGYPDSGTEVLRGVDLEIRPGETVALVGATGSGKTAVTELVPRLADVTGGRVTIDGVDVRDLELDELRRLVGTAFEEPILFSASVTENVALGAGDVDAERVREALAVARADGFVDDLPWGAETRIGEQGLSLSGGQRQRLALARAVAGHPAVLVLDDPLSALDVHTEAEVEAALRRVLADVSALVVAHRPSTVKLADRVALLSGGRIAAVGTHQELLANNEEYRHLLATMSDEEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZP2</accession>
    <name>A0A7W7WZP2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="166"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="23986" checksum="1D3C31EF8AAA953D" modified="2021-06-02" version="1">MAYRLARSLMVFRDEVNARWPNRDHASDGWIGDAAHAASNSDHNPWVKDAAGVGVVRAYDVDAGTGVNTEIGLWIAEHVRNLGLTGHPALGAGSYVISARRIASPVSGWAWRTYTGSNPHTSHTHVSVSLAAGGYDSSQGWSIANGTGPKPPTPGQRSTVRRGSKGPAVSELQRILNAWYPALPRLVVDGDFGPATETRVKHMQRAAGLVADGIAGPATWRRLLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZR4</accession>
    <name>A0A7W7WZR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8727" checksum="28C9C6B2B0733C7F" modified="2021-06-02" version="1">MTTAIVPPGRVLVCCGDHLPTGCCDAEDCAPCCPECPTCVVVQARTPEQRARDAAAHRDLLLALAAWAEDIEKGAPPWPTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZY0</accession>
    <name>A0A7W7WZY0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YbjT (DUF2867 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="2">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="487" mass="54017" checksum="337F3CCE272C9615" modified="2021-06-02" version="1">MRCLVTGATGYLGGRLVPRLLDEGHEVRCLVRDPGKLRDVPWAGRVEVVRGDVTDRDSLVPAMRDVDVVHYLVHSLHSADFVDADRVAAANTAWAAGNAGVGRIVYLGGLHPAHGQLSAHLASRKEVGDVFLRSSVPAVVFQAAVVIGSGSASFEMLRYLTERLPVMVTPKWVHNRIQPIAVRDVLRYLVEAVGLPADVNRTYDIGGPDVLTYLDMMLRYARVAGLRKRRVLPVPFLTPRLSSHWVNVVTPVPRSIAKPLIGSLVHEVVCREHDVREALPGPLTGYDRAVRLAIDRIRDGEVETRWSNASVPGAPADPLPSDPEWSGGSSYVDVREHRTAAPPDRLWSVVEGIGGEHGWYSFPLAWAVRGWFDRLAGGVGLRRGRRDPKRLHVGEALDWWRVEELERGRLLRLRAEMRVPGLAWLELRVAAADGGGSTYRQRAVFVPRGLAGHVYWWLVWPFHGLVFGGMVRNITSEAELTSEYRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXH6</accession>
    <name>A0A7W7SXH6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="18" type="ORF">F4559_000128</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="17">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="16">
        <location>
            <begin position="173"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="15">
        <location>
            <begin position="321"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBB4962769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="440" mass="45570" checksum="29DBD0ABA7761D81" modified="2021-06-02" version="1">MSVLVVGLSHRTTPVPVLERAAIADADLGKVLDQLIKAPSVSEAVLLSTCNRVEVYAVVETFHGGMNEVVEVLARQAGAEPPDLFEHLYVHYSAAAVEHLFSVAGGLDSMVVGESQILGQLRAAYGAADRVGAVGRTLHELVQQALRAGKRVHSETGIDQSGASVVSEALDDAATVLGGLAGRSALIVGAGAMGGLAAAHLRRAGIGEVVVANRTAANGARLAAALVADGITARSSGLDDLVTQVARADVLFACTGSVDTVVGAEHIGDREPGRPLVVCDLGLPKDVDPAAALLAGVRVVDLETLQRRLSDAPTGQDALRAAEIVAEEVRAYLAGQRSAGVTPTVTALRKRAAEVVDAELLRLDSRLPALDGTVRAELAKTVRRVVDKLLHTPTVRVKELAAAPGGDGYADALRELFGLDPQMPSAVSSPHTTRPKGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXM9</accession>
    <name>A0A7W7SXM9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein F4559_000216</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16020" checksum="DDDC9DBDFA7E3B4C" modified="2021-06-02" version="1">MALDQSFVGRSYPPSFVYEVGREKIREFADALGDGSPVYREVEAARAAGYKDVIAPPTFAIIVSLMANDLLVSDPELGLDYSRVVHGDQSFEHHRPITAGDRLEVVLHVDGITSRMGNDMLTVRAEISAEGEAVVTGRCTLVVRGEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXV3</accession>
    <name>A0A7W7SXV3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10301" checksum="C66D60FE5F416FF6" modified="2021-06-02" version="1">MNERIEVNFGELANAGGEIASQANQVQQALDDLKQRLAPVIAQWDGGASEAYQQAQNQWNTSAADLQSVLAAIGVAVQQATDAYQQAEQQNTVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY83</accession>
    <name>A0A7W7SY83_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phage-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900723">
        <property type="term" value="P:negative regulation of protein adenylylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11586">
        <property type="entry name" value="VbhA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041535">
        <property type="entry name" value="VbhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033788">
        <property type="entry name" value="VbhA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043038">
        <property type="entry name" value="VbhA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18495">
        <property type="entry name" value="VbhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4065" evidence="2">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="VbhA" evidence="3">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21979" checksum="10455A86D51C307D" modified="2021-06-02" version="1">MANVHDVAAAVLAATGPESPMKLQKLLYYAQGWHLATEHTPLFEARIEAWKRGPVVPEVYYRHEGRSEVCSWHEGDPSRLAARERDVVASVVERYGHFSRHELSEMAHGEEPWRDARGDLPESEPSSAEVSREVMARYFRRLFRPAPQAFADALASVSLEGLTVGEDTVATMREVAAGRLDIEDAIAREIEALRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY87</accession>
    <name>A0A7W7SY87_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15360" checksum="DDEE9CF1A7B9A118" modified="2021-06-02" version="1">MMEFLAWYDPEVDVPVVVRSASDLDRVIDVVKYDDGPTLIQLNALDPRDGLLVIGVFASKNRGTLLYRGPQGMWFSKGIAPYPGETLLYRYLDAEVDYPSDAEIPLHQVVKAAHDYLVDARLPAGPTWQPPPTWYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYF5</accession>
    <name>A0A7W7SYF5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">F4559_000627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13675" checksum="1FA69B6F0481C453" modified="2021-06-02" version="1">MTYPEHLLYTEEHEWVDWKPGTRDPVSVGITSYAASSLGDIVFVQLPDPGTVVKAGEVCGELESTKSVSDLFAPVAGRVVEVNTAVVDDPARINNDPYGEGWLFKVEVTAAEGLLTAAKYADFTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS0</accession>
    <name>A0A7W7SYS0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="467" mass="47212" checksum="B5D5C8A00FEFAD30" modified="2021-06-02" version="1">MSTHVDPVAKPAGSGTPHPLAVVVLAAALALDAGGVAVVNAALPVIGSDLDIDSSGLQWTMTSYAVTFAGFLLFGGRAADVLGRRRVFALGVGLFTAATVVAALAPDAAVLMVARALQGVGAALSGPASLALLTQLYPEGPRRNRALAVYTSVGASSFSAGVVLGGVLTDLFSWRAVFAFNVVIGLAVLLAVKAVLPAGTRDPRSLDLVGAAAVTGGLLLAVYGLSEAGHTGWTTPTTLGSLVLAVLLLVGFVCWELRTSEPLLSMRIFRLPTVTAATVAAVAFFTAVLAVLFFAPLYLQGLLGYTPLQSGLAILPMGMIVVVSSNVAGRVMARVGQKPLLVVGLLLIAAGVGLWALTPLDGQYWTHVFPSVAVMSVGQGVAFAGLTAASLTGVPQHEHGVAGGLNVTAQQLGGSVGVAALVTLATSVGTTETAQGLLDGYHAAYLASVAVLLVAVLAITLLMRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS2</accession>
    <name>A0A7W7SYS2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14334" checksum="1EABA27AED7566B0" modified="2021-06-02" version="1">MTVSTLDWGTTYRITVLDLGLACCGVEVMAALEGDHDLAALGVRPVHDAGEAHVLVVSGTVTDAMLPAVIATYQELPEPRYVLSVGACSNTGGPYWDSYSVTKGIDQVLPVHVAVPGCPPRPEALLDGLAALHRLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS5</accession>
    <name>A0A7W7SYS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="33919" checksum="8E7190C0DB4D020E" modified="2021-06-02" version="1">MTADSGHSAEQPGLPGALAETLRYGPFHRALHDAIAHRGLSLARLRAHLESLGVQVGQSTLSYWQRGLRHPEVPRAIGTVRALETVLRLPAESLVALVGQRPQPRPPRPAFAEMAGTWVRTRPLLGEFDSANADLEVLLVHDSVLVGTQGEQRSITTRLVVRALHGGPDRYVAVHQGDEGCVIDNAIVRAGEGCRQGRVRRQSSSRGLAFELLFDRRLAEGEEHVFSFTVLDDTGGPTPGHHRTFRRACRGYLLQLAFNRRALPARCTKQIRDSAQSPALEVDELICGLGGVASAYFGEIGPGMAGISVEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS9</accession>
    <name>A0A7W7SYS9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="38921" checksum="95442B025F3B8E8C" modified="2021-06-02" version="1">MVTGYDAVRQVLADTRFSSRQDLGVVHVPYETPGMPVATEPSPQVPGLFITMDPPDHGRLRRRLTGAFTVKRMKQLEQHIVDVVERQLDEMARLAPPVDLVEVFALPVPSLVICELLGVPYADRAGFQADSAKFLVKDQSLDEKMAAFGALTGYLAGLVVDKRAEPGDDLLSDLARQDDLTVEELTGIAFLLLLAGHETTANMLALGTFALLENPGQAAALRAEPDLVPGAVEELMRYLSVADIFYRYATEDVEVGGETIRQGSTVVVSLLAANRDPLRFGEPDALDVRRNARGQLSFGHGVHQCLGQQLGRLEMRAGFAGLLRRFPTLALAVPAGEVPLKSDMNIYGVHALPVTWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT5</accession>
    <name>A0A7W7SYT5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NBD/HSP70 family sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="40737" checksum="435AF1DC0A9F3674" modified="2021-06-02" version="1">MQEITSSSPRDIAGTLLSRIAERGGASRAELARETGWARSTVSQWIDRLGHAGLVVEGEAAVSAGGRPAIPVRLNPSAGKLLTATFGATHARIGVSDLRGDPLGETEKTVRLDQGPDHVLDWTQESFRELLGQVGATAEDVRAITIGLPGPVHFVHGRVVRPPIMPGWDGYPVKRHFAARYPAPVIVDNDVNLMALGALHDRFRDVDHLLFVKIGTGIGCGIVVDRRLHRGADGSAGDIGHIPVADSTEVCNCGREGCLEAVAGASAIAGELKLASPIEIAALVHGGDPKAVHAIRRAGQRIGRVLAGLVSFANPAAIVLGGSLAGLRDILLTEIRSAVIGQATDLATRALRIEISPPEVDVARLGAVALGREAALSPEAVRRLVEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYY7</accession>
    <name>A0A7W7SYY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="38776" checksum="FE852D94452AAEAF" modified="2021-06-02" version="1">MSRVESRTLREIGRCLATGRPHHALDHAFTLLSAEPHTPGRRFLLLTELAARAGRPVGAAYYGDLARRAFPDAPTPIEIPAFSYPVKEVQVSAMPPERAHYAVGRAEQALRWLDHRVTASPFTHDWARTTLLRETRASAHLDGVHLALIEVFQHVLPTSPGSLWREPAFSPYLAATLSLLDTPTPTPAAEPLLDVLTGYVRSPPADGHALRLALPVALVRARLLTRPWLPLSTHHPGTPDLSRSPREDVLAEVGRIADAVTTDQQTRSSVINKATRLIITPRRPTSLQTATITTDHFGCFAVRAFDLLGCDGIGGDVVTAVGRRSVLGAVWGWDHVVGVRVFNHMMAPRRCSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ42</accession>
    <name>A0A7W7SZ42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="40"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="33044" checksum="934D3FAF22B99C80" modified="2021-06-02" version="1">MSTRTAALLSALLLLTACGGGGQIGDTGGGGTDAKRLVLIPGVAAEPFYISMECGFREAAKAQGFDVDVQAPAKFDSTLQTPIVTGVLGNKPGAVLIAPTDDKAMAGPIRQLKDAGIKVVEVDTRLADTSIAVSTVSSDNEQGGRLAAQTLAKLVGNKSGSVLVLDTKAGTSTTDARAKGFEDELKKYPNLRYTGRQFTDNEPDQAASKTTGVLAGNPDLIGVFATNLNTGEGAATGLRNAGKTGQVNLIGFDASPKQVEDLKSGVVQALIAQDPAGIGSTGVDLAAKAIQGGAVEREVQTELVALTKDSLQEKYFYKQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ65</accession>
    <name>A0A7W7SZ65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="35110" checksum="5179F2C32F1CF795" modified="2021-06-02" version="1">MAADPRPHPHATAEEVEAAYADPKLANVLYHDWEADTYDEKWSISYDERCITYATDRFRAAAGDAGPYGHALELGCGTGFFLLNLMQGGVVDRGSVTDLSPGMVEVATRNAASLGLPVDGRVADAERIPYDDDTFDLVVGHAVLHHIPDVPAALREVLRVLKPGGRFVFAGDPTNIGNFYARRLGRLTWWLTTNVTKLGPLSSWRRPQAELDESSRAAALEAVVDLHTFDPGELERYARRAGAVDVRAVTDELSAALFGWPVRTFEAAVPRDKLGFGWAMFAYRTWQRLSWVDEHVLSRVLPKEIFYNVSVTGRKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ90</accession>
    <name>A0A7W7SZ90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="12377" checksum="13FCFDDF3F4E1F4A" modified="2021-06-02" version="1">MTDHHAGRGAAHRAEIDRRVTIMAAKLEHPSTQFLDEERYQRLRAEVRTLYWVTKEREHRPEWQDVITAVLNLLAALERLDPSLRREVEVALPAPRTTPHPTPCPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ92</accession>
    <name>A0A7W7SZ92_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045830">
        <property type="entry name" value="AraR_wHTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19368">
        <property type="entry name" value="AraR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25127" checksum="A8BEF1493D34FB4E" modified="2021-06-02" version="1">MAPRDHEIVRLTADLVILTVRSGRLCVLLVERANEPFRGRPALPGGFLRAGETIEETAARELAEETSLDGLPVEQIGVYSAPDRDPRDPRVVTCAFLAIAPDLPVPVAGTDAREARWLPLDEVGGLAFDHGRILADAVERARTKLQYTTVATAFCPPEFTISELREVYEVVWDVEVDRPNFHRKVTDAEGFVEPTGAKSTKGGGRPAVLYRAGGARVLHPPMVRPRAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC8</accession>
    <name>A0A7W7SZC8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="12067" checksum="C25C12064EF7BF27" modified="2021-06-02" version="1">MRYLVSVIDDRENPGSTDRRPAISEFNERLIAEGYWVFAGGLADTDTATVVDNRGEQVVFSDGPFVESKEYLAGVWVWEAPDLDVALKLATEASRICDRKIEVRPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZQ8</accession>
    <name>A0A7W7SZQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="30234" checksum="804B1427B13B50EF" modified="2021-06-02" version="1">MSRPRWLVATGLLTPTGLWLGLFLLAPLGLVVQFSFATRDTGVARVVLPWTVDAYTTALDPAFLPIFARTLAYAGTTTALCLLLGFPLAWFLARHAGRWRNVLLAAVLVPFWSSYLARIYAWKALLDDDGLVDRALGVIGLGRDGGFLLTHGAVVLGLTYGFLPFMVLPLYAACERFDFRQVEASYDLGHAQVSTFFRVVLPGVMPGVVAGSLLVLVPATGDFVTPRLLGGVDQSTFGSVIDDQFRGGNNWPLGSAMAVLLLLLVVVALVVRGRRGEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZW8</accession>
    <name>A0A7W7SZW8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030825640" evidence="1">
        <location>
            <begin position="30"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28917" checksum="8FBC053BE0CD6FBC" modified="2021-06-02" version="1">MRFKRAMAVVLGVAAMVTLAGVTPGVAQGNDRTFKGVERERGVSSATNGGQSLLEINSAGELVYWQRSGVSYSRQVRGWGWQNTQAITSLDAQHFIEIKGDGRLAKWSWNGGQYTQSIIGWGWDNARLITGISSGQFIEINKQGELAYWTLDGSNGLTKAVRGWGWQATRSITGLDPYLFIEIKGDALNSLSWWVDEASGLREYPETNSDNRWIRLIAGADADHFVVIAVDGTLVEFAWNAGTERWVGTERGWGWQGTRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T021</accession>
    <name>A0A7W7T021_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030869440" evidence="2">
        <location>
            <begin position="25"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="28"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="25443" checksum="0B17B8CC602F1DAB" modified="2021-06-02" version="1">MRTLLRALTASLLVLALVTPPATADPRIVGGQVVTDIAEAPWMVALVTTAGRHVCGGTLIAPALVATAAHCVATYRAEDLLVVGGRADLSKPVGIVSRTTQIVLNPAYKTAQIGADAALLYTTSTFPYPVLTVPSRSETYLYTPGTVGTVLGWGRTFENGPGSLQLRKALVPIVSDAECAAAYKEYVPKAHVCAGFPEGGVDACQGDSGGPLVVNGRLAGIVSWGTGCARPGKPGVYTRVTSYVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H7</accession>
    <name>A0A7W7T0H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="15518" checksum="1E998FABA91EDB45" modified="2021-06-02" version="1">MGIITEPAGEEEHPVTSSARVSGRIRGGAAVMSAVLVLLAVVLAIPLGVSEAGVALLGVLGWLVALAARLPALASAGRLPDLDRSRTILESASAITDEVVRSRSYWSLSADTLPRSGRASAGRWQNSFSSSRRTSRGSVGPSEAKRRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J6</accession>
    <name>A0A7W7T0J6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031160880" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="27537" checksum="3E96A66216552551" modified="2021-06-02" version="1">MTELRADCARCVGLCCVVPAFAKSVDFAIDKPAHTPCPNLADDFRCGIHTRLREKGFRGCTVYDCFGAGQQVTQVTFGGTPTARARAVFPVMRQLHELLWYLTEAARIAPDRATTARLDEIAALTRETPENLLALDVGPWWREVDAIMVKASEAARKGLRGKNKRNADLVGKDLSRAGLRGATLRGAYLIGARLRGADLRRVDFTGADLRDADLSGADLREAFFLTQSQLDAARGDRTTRLPEGLRAPAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T6</accession>
    <name>A0A7W7T0T6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17184" checksum="6CFA476DA8690B59" modified="2021-06-02" version="1">MSMRAGLWTGLPDLDQAEHRYQVVGCAADVDLLITYLSRPDCNDATLEHFGRDTDADGEADHNVVLAVRGPWGYVNFVDNAFSGWPKGDPAAPYVDEPYTDYPPGVGVSLPMFRELLLEFLATGRRPKVVEWYDEGELFHSWRLQRMALHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z7</accession>
    <name>A0A7W7T0Z7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ornithine cyclodeaminase/alanine dehydrogenase-like protein (Mu-crystallin family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029447">
        <property type="entry name" value="DUF4439"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14530">
        <property type="entry name" value="DUF4439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4439" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="14816" checksum="A39A13134DA365D0" modified="2021-06-02" version="1">MSVEAVQRALAAEHAAVWTYGLVSAFIDEQAAAVAEGADAHRARRDATERWLRDAGATPQPPAVAYLPPRPVDGAPTAMAALVSVETDACVAWRGVLDRTEDTTVRTAALDALTTSAVRATRWRRLAGITPASIALPGTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T159</accession>
    <name>A0A7W7T159_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ctaB</name>
        <name evidence="9" type="ORF">F4559_002018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="33263" checksum="49DBE9A115B2BD90" modified="2021-06-02" version="1">MSAVTEAPARTPRQVVGAYVALTKPRVIELLLITTIPAMLLAARGLPPLWLIACTLAGGTLAAGSANALNCYVDADIDSVMKRTGARPLAKNAIPPRNALIFGIVLGLVSFAFLWLTTNLMSAVFAVATILFYIFVYTLVLKRRTSQNIIWGGMAGCMPVIIGWSAVTGTVGWPALVMFGVIFFWTPPHTWALAMKFKEDYARAGVPMLPVVATAQQVTRQIVIYSWITVVCTLLLAPVTSWIYVAVAAVSGVWFAVVAHRLHNVVRKGGTTNTMPFFHLSNLYLMLVFCGLAVDAVVGLPALGLPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F2</accession>
    <name>A0A7W7T1F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein YiiM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23540" checksum="72514C3BCE26E5D2" modified="2021-06-02" version="1">MASVLSLNVAERVEFPVVFGSTGIHKRPVEGRVAVRAPGPSGTGGSGIVGDHVADLRVHGGDDKAVYAYAREDLDDWAAELGRDLPAGLFGENLTTLGVSLTEARIGERWRIGSAVLRVAGPRVPCRTFALVMDEPGWAKRFIARAVPGAYFAVAEPGELGTGDAIEVEHRPDHDVTIGLAFRAVTLEPDLLPRLLAAGDDLPARVRERVERRATYSPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R4</accession>
    <name>A0A7W7T1R4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="35215" checksum="96F629465018B47A" modified="2021-06-02" version="1">MAEADVVALRDFTHDLRALDHRYGGLRSCAEVTDRLPSALALLSRPAHDRIVVPLRTAVADLFNLVAWTSFDVGRVGDSLAHFGTALKLASSIGHDALMANIYYRLGRVWLHHNAPGPALAEFRLGERAARRAGSALALAVVNVNQAWAYAHMGMEHEALALLSDVPTTFAHAQGEPVSDWAAFFTPADLSGMTGVIHTQLGQSVDPRFVELAVPALDSAWESYPAEMVRSRAFCLVALATCHLLDDQVDTAIELGGRAVALCEGLESARVVERLRPLRNEALRRRNRTDAAALVERIGRLRAVVVGLPRPPAGPWIRTRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W6</accession>
    <name>A0A7W7T1W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SagB-type dehydrogenase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20400" checksum="EB83DC8165EE577C" modified="2021-06-02" version="1">MIVLPEPGDVPMPLGEALRTRRSRYSYAPLAPDLLSTLLHNALGVQRHQESHVLGMAPNAGGLPSLRVHVVHDGEVYEYLRGPHDLVARGKSDLTGVFAQEEFARRAHTVIVLSGHLGPGLAKYGERHHRTVHLDAGVAVQNLYLVATALGLNGCAVAGFADAAVAALVGAPYPLALFVVGATPRNGHKNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z6</accession>
    <name>A0A7W7T1Z6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="10">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-IPM isomerase</fullName>
            <shortName evidence="10">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">leuD</name>
        <name evidence="12" type="ORF">F4559_001229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047508">
        <property type="term" value="F:(R)-2-methylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21881" checksum="5F363194059E535F" modified="2021-06-02" version="1">MEAFTTHTGVGVPLRRSNVDTDQIIPAVYLKRVTRTGFEDGLFAAWRGDESFVLNQEPFRAGSVLVAGPDFGTGSSREHAVWALMDYGFRVVLSSRFADIFRGNAGKQGLVAAQLEQSDVELLWKILENEPGTPVTVDLAAKTVSAKDFSAPFGIDDYTRWRLLEGLDDIALTLRHAEDIGGFEGRRPAWLPTTVPPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T209</accession>
    <name>A0A7W7T209_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surfactin synthase thioesterase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26081" checksum="9431B9B1E51C5164" modified="2021-06-02" version="1">MSKWLPRRHKRPDAPLRLYVFPHSGGSAGEYLLWADDLPRVEVVGVQAPGRGGRVEEDAYTRMSDLVAAVVAEAAFTGPFAFFGHSLGAVVAYEVALALRAAGREGPRHLYASAHEAPHRTVPRPHALDDASLIAAVEAEHGPLPAEIHEDAEWRSLVLGGLRGDLGIVSTYGRTTAPPLDCPITAFAGADDEVAADDVAAWAGCTTGPFRLRVFAGGHFYFREQHDDILRFLAADLDAVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T226</accession>
    <name>A0A7W7T226_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21629" checksum="9EF5BA6F9E8DCADA" modified="2021-06-02" version="1">MSCAHTVSLGAYLLGALDPAERSAFERHLDGCVTCPREMVRLAPLPGLLSQVRPEDLEPTARPPVPPPAVRRPTRPRLPLLAGAATLLVVLAAAVVLGLRFAGADEPVTWRATDTATGVSARADLVGRSWGTELWVSTDNVPKGSRCKLVVHDRDGRTEVGGWWGADRDAGARIPGSTSFDVDRIDRLDVVVDSTVVVTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2B6</accession>
    <name>A0A7W7T2B6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Immune inhibitor A</fullName>
            <ecNumber evidence="3">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012300">
        <property type="entry name" value="Pept_M6_InhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007519">
        <property type="entry name" value="Protease_InhA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030646635" evidence="1">
        <location>
            <begin position="27"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M6" evidence="2">
        <location>
            <begin position="93"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="783" mass="86031" checksum="CBE960AD19CB1F96" modified="2021-06-02" version="1">MRRLLISAATVALVTTTAVVPTTAVAAPQPSTEQPTAQVDDLPNPLEANRRALRQEALAKVLTGEATKEKRGASTVVKLGSKQKKGAKAKVGQYVELEREKVDKIFVVLAEFGDERHPQYPDQDTAPGTPGPVRFDGPKHNQIPQPNRAVDNTTIWNPDFSRQYFQDLYFSTQPDANSVANYFDKQSSGRYSVSGTVTDWVKVRYNEARYGRSNGYPCAGNTCNNAYDLVRDAVAQWVTDQKAAGKTPEQIKASLAEFDQWDRYDYDGDGEFNEPDGYVDHFQIVHAGGDQADRDPWQGEDAIWSHRGYAFKNYNTGPGTNKLGGAPIGDTGLWVGDYTMQPENGGVSVFAHEYAHDLGLPDHYDTSGGATNGVNWWSLMGQTRVGEPNEAPGTRANELSAWDKLQLGWLDYEVAVAGQERTFDLGPHEYNTDKAQGLVVVLPDVEKTFDYGAPFAGSRMWWSDKGNDLDHSLTRSVDLTGKTSAALTLKARYDIEEDFDYLYVEAQNADGSWTQLDGTVGGKPFVRDSGDAPAVSGSSNGGWVDFRVPLDAYAGKNFKLRFAYRTDGGLALQGFFADDITVTADGAPLFVDGGEAGTGAWTLKGFRTTAGTETKKFDQFYVASNRTYESYGKYNRTGPYRYSFPDKPKWVEHFPYQDGLLVSLWDTAYLDNNTSEHPGEGLILPIDANPAPIYNLEGQAWPATVAGYDAPFGLQKSDSFTLTVNGKKSYVRGQAAKPVFDDTKKHWYAETQFTGVKLPAVGVGLRVLSQSGTSLKVKLFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J7</accession>
    <name>A0A7W7T2J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiopeptide-type bacteriocin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="2">
        <location>
            <begin position="51"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1059" mass="114445" checksum="D430E567B1188B5D" modified="2021-06-02" version="1">MTVSPRYRHTGLVLARVTTDPGDLDPVTQTDPADPVAVEQDGRAWLAKVWARPEARDALTLASPVLGARLDRILGEDTSTPTAKELRRAVVSVASYLLRWQRRATPFGLFAGVGPVAVGPATAEVGTRHRAVARADGEWLTTLIDRLDRHPGLRPRLTVVVDTARIVRDGRVIVHRRAEVGASAPGPLRESSVRLTRPVQYVLTAAGSPVRFDTLAEKTSVRFPSASPDKVHALLHGLVDAGVLITSLRPPTTGVDALSHLIGALHAAQACTLDDLAAPLRELDAIRADLARHNNAGDPAQARRIRAAVAARMTALAPGVGHALAADVRLDATIAVPERVLDEAARAATVLLRTGTRPFGSAAWLDYHARFRARYGPGALVPVRDLVADSGLGYPAGYLGAPRARPAWRVLTDRDAALLALIQQATLTGAREVELADADVQALTVGEHVDTVAPQRIELGAEVHAPSTEAIDRGEFRLRITAAPPAHTSMAGRFAHLLDDADRARLAATYTAGPAQPPSREVFDTAVAVQLSFPPRRPHNENVVRVPPLLDDVVSLSEHPGHPDPARPDPTVIEVDDLAVTADAEQMYLVQVSTGRRVMPRIPHALDTAVQSPPLARFLAEVADARSAVFRGFDLGAARVLPYVPRIRYRRTVLSAARWILTAADLDTRPEADHPETDRPGAVDGEQPLRSWRQRWGVPARVVLVQGELRLPVDLDHVLDRALLYTRLERTGRIELHEDGPPDGHDWIGRPAELLIPMTAITPPTRPLPATAAPDAVLQPGDSAVVHAQLAGNPARFDEILTTHLPRFVSELHDPRDPDPSVRSWWVRRHRDMIRPETDHHLALFLRLSDPRHYGALAARLAAFAADLDSRGLPGQLTLAPMPQHPARYGHGPALAAAEQVFATDTTAAITQLAAARESGIPAQALAAASMAHLAAAFAPDPVAGHRALLECLRQERGPLDRVLRDRALAVADPERKYRAVRALPGGQTVVDAWHARDTALGAYHRALVQQDRDPGTVLRTLLHEHHIRAVGVEPAFEKETGRLARAVALRHLALAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3H2</accession>
    <name>A0A7W7T3H2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="145"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="33793" checksum="796DF4717CC1279D" modified="2021-06-02" version="1">MRRRGRRLGWLSFALGVVQLAAPGAVRRLGGVDDSARSRAVVPVVGVRELVHAAGLLTSRRKGAWAWTRVAGDAMDLAALGVALSRRDGGRRRRLVGVTGAVAGITALDLLTAVQATREARTSSPPARGVRKGGSVELTATTTIRKPASEVYAFWREVENLPTFMAHLEQVRATGDRTSHWSASAPFGKDVEWDAEITDETPGEKIVWRSTGKAAVPNAGTVHLTPAPDGVSTEVHVVLVYDIPGGAVGKAVAKYFGEEPHQQLDDDLRRLKQVLETGEVVRSDGAPWGKRARAEFPQRPAQPLSDAEREKGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3H6</accession>
    <name>A0A7W7T3H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="98"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="224" mass="23862" checksum="20EB34DF896C09D4" modified="2021-06-02" version="1">MDADWSSELTARARLHAALGEPARLAIVDRLLLGDASPGEIGRELGLASNLLAHHVKLLEQAGVVGRSRSEGDARRSYLRLRTAALSGLVPSGVRHARRVVFVCSRNSARSQLASALWAARSEVPAASAGTRPAGEVHPLAVATAKAHGLSLARARPHHVDRVMRPDDLVVAVCDNAHEELDPADRLHWSVPDPAAVGTEAAFDAAYHDLADRVDRLVPAVHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P7</accession>
    <name>A0A7W7T3P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031556841" evidence="3">
        <location>
            <begin position="31"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="207"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26655" checksum="9AE8641F980364EB" modified="2021-06-02" version="1">MNFRRKLATVLAGAVIAPFIVVMAAGTASAHGYITSPPSRQANCATGKVSKCGDIIYEPMSVEGPKGQTNCHGGDARWAPLSDESKPWPAASVGDNVTFNWAISARHATTTWQYWVGGTKIAEFNDRGKIPGATVRHDVSLGGRTGRIKILAIWNIADTAMAFYNCVDLQVGPGGGDPTTTTTPPTTTTKPTTTTVPTTTTTPQQPGGAWAAGVSYTAGTQVTYGGATYKCLQSHTSLNGWEPPNVASLWQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S2</accession>
    <name>A0A7W7T3S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn-dependent metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001570">
        <property type="entry name" value="Peptidase_M4_C_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013856">
        <property type="entry name" value="Peptidase_M4_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01447">
        <property type="entry name" value="Peptidase_M4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02868">
        <property type="entry name" value="Peptidase_M4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030976232" evidence="4">
        <location>
            <begin position="27"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="5">
        <location>
            <begin position="730"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="778" mass="80210" checksum="42EA03EA9E679486" modified="2021-06-02" version="1">MKRKIGIYLAAGLAVVSGYVATTATAAPTDSTAQAAAPVALAEAAADKATAAGLDALAKGPDEQFTRRQTYQGGIPGKKDLFYVSYDRTYKGLPVVGGDAVVTTDASGNVLNTVAANRGGFSVDTKATLSAKQAEGVAKGQLAKVDKVVDNKLSVLAGGHGTLVYETVVAGRKADNTPSRLHVFVDARTGKVVETYDDARAGTGQSEWNGPNPLAIDTSNNQTVDSTRPGLSCVDYSGKQPFTKSNNSFGNGQATSKETGCVDILWSTQHQWDMLKNWLGRNGIDGNGRGVQVQVGLNQVNAYWTGDHIEIGHNNANQWIASMDVAGHEHGHAIDQYTPGGAGREAGLGEATGDIFGALTEAYTNEPSPYDTPDYTVGEKVNLVGRGPIRNMQNPSQVNGDPNCWSSSIPNTEVHKAAGPLNHWFYLLAEGSAQSPTCNNSTVTGIGIKDAGRVFYNGMLQKTSGMTHFRYRVATLTAAKTLDPTCKFFEATKAAWNAISLPAQSGEPTCTSQDNQFSVTINPSSGSVDAGGSATATVSTATTSGSAQNVTFSATGQPTGSTVTFSPASVNSGASSTFKVQTAANTSPGTYPITIKGTGTATNHTVVFNLTVKGGQPGENDFSLALSPTTGSTKAGSAVSTTVGTTTTSGDAQKVSFQADGLPTGVTATFTPASVTSGENSTLALQTSASTPKGTYTITVTGSGANIKHAATFTLTVEDGGGGEPGCGGLEAWSSSKAYVPDDLVSHNGRKYKSTWYSAGAEPGAPGSWAVWQDQGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S9</accession>
    <name>A0A7W7T3S9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methylcytosine-specific restriction endonuclease McrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16773" checksum="6BDDC68B8C8EE4D6" modified="2021-06-02" version="1">MGVLVLNASMEPLHTVSVPHAVRMLVRKVAEIHEAEVDSTIGVFPLPRVVRLVRYVVTRWRYARPPRWSRRGVLRRDGHRCAYCGGPADTVDHITPLSRGGERTSWLNTVACCGRAARSCNSRKGDRLPAEAGMRLLVTPYVPTWADLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T453</accession>
    <name>A0A7W7T453_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH lysR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23646" checksum="82FEA44855D6FE74" modified="2021-06-02" version="1">MIDIRHLTSFPAVAGERTITRAAARLHLTQQTVSTHVHRIERALGITLLVRTSRGVLLTPADAELAAGGQAVVDDLAAPANRVRAVASGQAGAVHLAWSHWRTSATNRPCCPTCARRPRPSGTGWWTRVPPTARRRAAGARRRWRTRSWTSRAGGASGSHRGHWAGSRPPGTCAGSRSSTRRRSTSRSVWTDRAPRDVIARLVAEVRSVTGFRDLHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B6</accession>
    <name>A0A7W7T4B6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_003703</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007891">
        <property type="entry name" value="CHASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05227">
        <property type="entry name" value="CHASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="210"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="277"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="527"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="666"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="831"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="788"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4966344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="930" mass="99187" checksum="628A06B6DB321FD2" modified="2021-06-02" version="1">MTGRRAWWTVGRLLAVGYLLALVGLLVVGVSAYLRIGTLLNDRVPVEHTYNVLNTISQLRIDVQNVERGQRGYLITGEDKFLVPYETALGNIDATVAELRVLTADNPAQQAALNELDPLLAGRLQQVADTIAARRSGGLEVVAPMVSRNGIDDAERVQAVLDGMRDRELTLLRERQRTSTAKAQDTRLLIGWGTAGLVVLVGVGAWWATRRVTVPLTKVAEAAARVAAGEAGSNVRVEGPAELERMARAVDGSMRALRDARDEAMAASRAKAAFLATMSHEIRTPMNAVIGLTGLLLDSDLTVEQRDLLTTVRDSGDSLLSIINEILDYSKIEAGQIDLEDVSFDVVECVESALALVALPASDKGIELVGHVDPGCPRVLRGDATRLRQILLNLVANAVKFTAAGEVAVTLWVEPADVTGLLVDTPHDDDAIMLHAAVRDTGIGMSAEQQSRLFRTFSQVDASATRRYGGTGLGLAISKRLAEAMGGDLTVDSASGVGSTFTLKVLMHESESTIGDVPATAPAHGRTALVVDDNDTNLRVLSAQLTAWGMECVAVHSGYEALDRVASGERFDVAILDMNMPGLDGVRLAERLRGLGGTKTTPLVLLGSISEPLTPPHRRMFEAVLTKPARVTVLHATLGRVLGARRGRRVETAMVDGKSGGEGSLRVLLAEDNPVNQKVARLMLDRLGHRVDMVADGAEAVRAVREGGYDVVLMDVHMPLMDGLEATRAIRAEAQDGRGPYIIAMTASVLLEDRKACAAAGMDDYLAKPVRADDLAEKLAVLGEGAEKPFVPQARTGHEHQAQPDREQSDREAAVRARLAELGGPESPPEERALLGALLTSFVNRSATAVQRLDDALRTGDEAGAAEAAHSLKGAASNLGADRMATLLSGLEDRIRAHDLPDPEPSLDPVRRELDAVTATMTAIAAELAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E1</accession>
    <name>A0A7W7T4E1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavoprotein involved in K+ transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="342" mass="36983" checksum="EF390145867DA526" modified="2021-06-02" version="1">MIDTAVIGGGQAGLATAHALLRAGRTPVVLEAGAEPVGSWPFYYDSLTLFSPARYSALPGMAFDGDPDRYPRRDEVVDYLRRYASGLDADIRTHHRVDAVRRAGDGFVLTVGGREVRARRVIAATGSFGRPHRPALADGFTGTLLHAAGYREPTPFAGRRVVVVGAGNSAVQIAVELAGHARVTLATRVPVRFVRQRPWGRDVHFWITATGVDFVPVGRLLRNPPHPPVLDRGHQRAAFAAGLLDRRPVFTRVDGDVLTWADGTRERVDAIVLATGYRPALSYLDGLGALDGRGRPVHRSGLSTVVPGLGFVGVEWQRTLGSATVRGVGRDARHVVRRLPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E7</accession>
    <name>A0A7W7T4E7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="39"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="32223" checksum="2CA7EC10B47CE846" modified="2021-06-02" version="1">MTSELPHQILDLAGNLTGIRTSGAELIRNGTNSVHRLPGRIIARIGPPESVETARHQLTVSHWLTQNDIPTVRPVADVGQPVVVSDRPVTWWKEIPNQRPAAPAELGTALRRLHTLPPPEGLLPTVDPIAGWADTIGTHAALTDDERMWITDLVARLRDRLTSAHLDTCVIHGHAWQDNVVVSGDGPPILLDLDRLGIGPRDWDLIPLAVDHTDFARITSDDYHAFLHAYGGYDTTTHPAYRTLATLMELRWTNYILGKATTDPHAAHEARHRITCLRGEIPRPWTWTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J1</accession>
    <name>A0A7W7T4J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MGT family glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="33883" checksum="28A350D239D51746" modified="2021-06-02" version="1">MKILFVTLTGHGHVTPTLALVAELVRRGHHVDYATSHVDAVAAAGATPVPLPAPGPFDPAGADVVPRWFRHYFAAMRATHPILLDHCRRDRPDVICHDATNWPARIVARQLDVPAVRCVPHFASNASFSLMSPDLVAHLADDCAAFAAGQGVDLTPADTLDSPEAVNLVLVPREFQPAGETFDDTFHFVGPLLGDRVDEPWTPRHPDLPLLYVSLGSMMTDAALYRACVTDFADGAWQVALHARTTDPVPSTVDVRDWFPQPAVLRHARAFVTHGGMNSTMEALYHGVPLIVHPLPPRAGGERRPHPRFGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4L6</accession>
    <name>A0A7W7T4L6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="826"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1118" mass="120586" checksum="BEC0F47C43ADE094" modified="2021-06-02" version="1">MPDHSALFADVDDALRRLPTGSVDPVDAGDLGLLALEHAEDAPADLDVAAGVVVLLRHAVVRAGDHADTALWWYSLAVTYRHLGDWDAVLDCARRSLAAGIARREFVDATLPELARMHFEWAQNREPWDLAGVRVARDLLGDSADFAARVAEGGPRTELARWRVGLMMLCFHVHADPVLLDGMEALTADLPAELVGMVRFVVETGRLATATDQAEIAERADRVFASRERIAAAGDPELVDQVTEVFFQLAADSDPVHLRRVVECAGLALGLPRSDPAATLRRHFQRLGSLLRLPPAAYRDYPLEQWLDDGEAALYAVTDAEPELIARAAATMALGRQTLIATRWQPMDMAGMVTHSRRARELVAHARGAGFADATLEARLAVLDEFARTVESLFTGGSTVDIAHMLDLVRGTGGEMGDVAASLAMLSGFTTGDRAATRAVSDLASDSPEWEVLRAFAESADLFGTAGPGDPRLLALREQALRISHADLRDAMVGMVDLATGARPATGTVDRNTWYGRIFDHMSVSMRAREAAARGDQRAVRAACARLDDLVRAAPDGSDEQALVRTSRANAYEMLPPTRGVLDTLVEDYTVHLDRDRKRRAVTVVASAMVLARTLRTRRARGDLDASRRLGMEALAWNGYRVLLQAGTADAVESARDRDRRVEPVVEWCLADRAYDDLVRVLDAQRSLVLGAATTGRTVAARLDALGHEDLARRWRAHSGREDETGWSGLRNLVLAALAEGGDALPEAPTVDEIRAALRAHGSDALVYLLPATAHGPGRAVIVPVDAKVRVRDLPGLREAPAFTRYVAASGRERLDALGDLCTWAWEAVGRDLLSALRHLAPGPRVVLVPVGALGLVPWHAARHPDGYLVRDLTIGYVPSARMLCDVVARPAAHGGAVLLGNPTRDLPYAAFEAEAVREDFFADGVLLGGSGRQRRWTPCADGAGTPEQVLEAVAKPLRLLHLACHAGVDVELPLRSTIRLSGADLTARMLLETSPTRAAELGQVTLAGCQTGVSGADYDEALSLSTTFLALGARTVVGSLWEVPSGKPTAQLMYVLYHGMHVAGLRPGEALRRAQLWMLDPDRVVPDGLPEGLRPDPCPDVDQADPVCWAGFAHLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P8</accession>
    <name>A0A7W7T4P8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP/maltotriose-dependent transcriptional regulator MalT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="23961" checksum="DC4286ABFBA64330" modified="2021-06-02" version="1">MSLTNGAVPRERLFALLDKLVGDAVTLVHAPTGTGKSTLLATWADRCGPHVALVNVERRYGEPDVLRQAIHDASTRTRSCLVLDNADRLAGSPAAHLLTGLARDRGHGLVLAGRSSLPLRTWLRAHGGLAEIRAEDLVFTRQEATALLRAHHVHPSLDDFDALLARTGGHAATLRLAVTSLTERGTPTVPRPRDPARSPHSPVRTSHVLDDVESAPRGDSVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T538</accession>
    <name>A0A7W7T538_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031139330" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16753" checksum="CB54A0479A33EC4C" modified="2021-06-02" version="1">MKFGRVAAVFAAVVLGMLGVMAPQASAADAWHWQSQWDSGYLDYNPTNGVHTRPWNGGPYQLWEYKRYSDGTYRFMNVATKLCLDNSEYGVRAFGCNDGAWQRWDMNDWGNGNWELVSMWDHRCLDNSTYGIRTVGCNGLSYQLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T553</accession>
    <name>A0A7W7T553_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="29021" checksum="B8649F159BFA8607" modified="2021-06-02" version="1">MESFRTPGGVTLGIESFGDAGAPLVLLVGGPTMLSWPDGLCLALARGGRHVVRYDLRDSGASTTVDPDAPGYTLRDLAADAAALARGLDDRPAHLAGVGVGGFVAQVAVLDHPDAFSAVTLVGTRPVAPGPVDDALPDHDAAALGRLFARPMPDWSDRAAVVEFAASGAGILGDDPVAAGDRAGRIFDRTPGTEPAVVMANQLGMVFSRLDRTPRWRERLPEVAAPTLVVHGRHDRFFPVGNGEALAREIPGARLLVLDQAATAIPDPAVDVVAEAMLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T579</accession>
    <name>A0A7W7T579_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nitrate reductase gamma subunit</fullName>
            <ecNumber evidence="15">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_004178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="30"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4966819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="29701" checksum="88D38E6B44E70490" modified="2021-06-02" version="1">MTPPTTATAATTPWLTAQEAGTTSSSTLDIMLWVVVPYVSIAVFIVGHVWRYRYDKFGWTTRSSQLYENRLLRLGSPLFHFGILLVALGHVGGLLVPKSWTEAVGVSESVYHAVAVGLGVLAGVCTLVGAAILVYRRRTVGPVFSATTRNDKIMYVLLVGTIVLGLGTTVLGNLTDHPHDYRESVSPWFRSIFYFQPEPSLMAAAPLGFQLHALAAWALFAFWPFSRLVHVFSMPLGYLTRPYIVYRSRDERQLGSRAPRRGWERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T583</accession>
    <name>A0A7W7T583_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23530" checksum="9403B3F642BB3931" modified="2021-06-02" version="1">MADSPAPAPRRTPGDRPSDVDLVARVTAGDRGAFGELYDRYARPAYSLARRICVDQGLAEDVVQEAFLSLWRNPGGYDRSRGGFGTWLMTVVHHRAVDAVRREETRRRRSVPLTDDESERTTEPAAGADQDALASVVGAEVREALKRLPEDQRRVIALAYLGGYTQIEVAALTGIPLGTVKSRTFAAIRRLRTTLRSVWSGETGETPGTTTGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G4</accession>
    <name>A0A7W7T5G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="130"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28542" checksum="467C5D04A385BCF1" modified="2021-06-02" version="1">MTADSIESAEQLADAWRLLVLDREPDADVRDLPGVAVRWADGLFPFWNCVTLTEADVDADLLGHRLAAAADVMRAKRGSGFLWLFEDLLADDARAALDAAADRAGFEYSFPGTGMAGDLLPLAEPEHPDLTFVRVTTDEHLDAYADLNARAYGFTREQGRAAFAGSALWKNDVHAYLGLLDGVPVTCAGSVAVAGRLFVVLVATDPDRERRGFGAAVTRKVLHEGGRATGLTRATLHATAAGAPVYRRIGFRPNSAIRFYRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C1</accession>
    <name>A0A7W7T6C1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA ligase</fullName>
            <ecNumber evidence="10">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ligA</name>
        <name evidence="12" type="ORF">F4559_003404</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="573"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="10">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="30"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4966045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="662" mass="71034" checksum="FE7FD273E8AB0308" modified="2021-06-02" version="1">MNAQERIRELADQIVSLRDAYYSGSPLVADAEYDAIEDELRALVAAHPEWTPDPNPLEQVGAPAVLHAPVRHSRPMLSLEKATKPEQVAAFFDRFPGQPVVVMPKLDGLSLALVYEDGRLARAVTRGDGTTGDDVTPLVRALVDGVPPKIDTSGRVEVRGEAVMLRSTFAAYNETHQDKPLINPRNAAAGTLRAKDPAAVAGRRMVFFAFDLDASDGAAADLEQGLRTFGFTVADMRHCSDAAAAQDVISDIERERNELDYDLDGAVLRLANRDAYSAAGTRSNSPRGALAYKFAAEEKTTVLADVVWDVGKTGKIAPVAWLEPVFVGGTTVTRATLANQEVIRAKGIRIGDTVLVRRAGDVIPFVAGVLDESKRTGEEQEIVPPTHCPSCAQPLTEQGNSRELFCTNVACPAQTVRRLIHWASRAAADIDAIGPVWIERLAETGLLENPSDFYTLTKERLLEFDRVGETSATRMIESIDKSRAVGLRRALIGLAIPMASEGTSARLCKAGFGSLEEVADAGEERLVAVEDIGPKVAASLTEHLARLRPELERLRERGVSLDVREEDLPAVVASDAPLAGKTIVITGTISDPRSGEKVPRPTFQRLCEKAGATATSSVSATTDLLVTGADVGAAKLTKAEKHDVEVVDQSVIWAQLIAAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6R3</accession>
    <name>A0A7W7T6R3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="27568" checksum="BDC24364B22E8AB6" modified="2021-06-02" version="1">MRFDAGRLVEVAVEVATEAAELVRTSRETAVAEVDTKSTVTDVVTAADRASEQLVRALLATRRPGEPVIGEEEGGTAAVEGLTWVVDPIDGTVNYLYGIPHYAVSIAAQVDGVSVAGAVVEPASGRVWTAAAGGGAWLDGRRLAVSAVTRLEVSLLGYGFAYRADRRQRQAETWAAMATRVRDIRRAGAASLDLCAVAAGRLDAYAEHALGRWDWAAGALLAKEAGAVVLLPGEAPELGADATFAAAPGIADALRATLAESGFGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6V6</accession>
    <name>A0A7W7T6V6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="110"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="33684" checksum="4227640479685A36" modified="2021-06-02" version="1">MGQEFDDLASATVRRWQLTEGLRQLREQRELTIDDVMERLRDAPGRWSRSKLSRVETREQRVKPHEVEQLLDAYEVTDEDTRTWLVDLAATAHRRGHWLSVRKDLPEDFHNLLSVEPALVARRQFETMVVPGLLQTADYTRALIHGINPGITHETVERRVLARMARQHVLARPVPLRLHVVLDEAILERQVGPASVMRNQLQRLADTGSQEHITVQILPRSVGVTPALLGPFSLLTLPDPIPDFGYTEGPGGAIYIEDRAAVRVCTERWGILTGRALPASDSLDAIKRAVKTYDQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y3</accession>
    <name>A0A7W7T6Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysylphosphatidylglycerol synthetase-like protein (DUF2156 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="8">
        <location>
            <begin position="471"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="821" mass="89289" checksum="E8125E31AA57A520" modified="2021-06-02" version="1">MIVRFLRRAPLTCAFLICYWTVGTLTGVVQGRDDDLLDRVGVGLGSPLWTMLGSALWSTDPLGYLATTVLLLGFGPRAERVFGAARTAAIFLAAHVTGVALGLGLVLSGRELHWSWLESLDGEVAVGPSIGGVGLALALSFRIPPPWRRRVRLLTILSSLVLALYSGWLLDVLRLSGGMAGALIGVVFLRRGPVPRTRSVQETRVLVALLLAASALGPVVAMMSPYPNGPLSWFADVVVVTQPSPEFVDEVCGADMVDACRTMTIQLTYDRFPALVMSLLPALLLLVLAEGLRRGRVFAWWSALVSNAAYAGFIGWYLMAVARFPDAGVGEAAFSLAVPMLAPLAMVVVLVVTRGHFTVRLPRHAARRFRRFTFGSVALLSALYVFGGYLVRDQFTPEPGFLRLLADLPTRFLPPGYLDLVPLQFAAEGFVGALLFEYTGVVFWLIVMTGLLMASWRAWPCSGAEAAERARELVRRHGGSSLSYMTTWRGNQYWFTPDGGTAIAYRVVATIALTIGDPVGPARVEAVRGFTEFCAHNGWTPCLYSVGAETREAVERLGWSAVQVAEDTVIDLPGLSFTGKKWQDVRTASNRAAKAGITAEWCTYADAPFAITDQVRSISAQWVADKGLPEMGFTLGGLAELAGDGVRCLLAVDGDRTVHGITSWLPVYADGRVVGWTLDLMRRRAHGFAGSMEFLIASAAQRFRAEGAEFLSLSGAPLARLDRGERPRALQRVLDFTGQVLEPVYGFRSLFAFKAKFQPTYRPMFMAYPDSAALPRIANAVGRAYLPHLNARQGFRLATRMFLRTRRRTTAGDRAGRVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T795</accession>
    <name>A0A7W7T795_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26240" checksum="916C5920573DE0E6" modified="2021-06-02" version="1">MRYPPIASGVLIPRIQAALRASIVDDSVRVGPFLVRFDAGSDHPFLNYAVPDDGADPTSEQVAELVAAFRARSRTPRLEYLRPAPAADAALAAAGFTVDQLLPMMAIDALTAPPTPAGVALALATSDADLFDVATVQNVGFGVDAPATDSDVARQRAVLDAGGFAVVARLGDAVVGAGVATAPHDGLSQVAGIAVPEAFRRRGIASTVCADLTARVFAAGWTPFLETEPDGKVTRLYGPLGFYKIGESAAVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I6</accession>
    <name>A0A7W7T7I6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="41558" checksum="1C366176822520E9" modified="2021-06-02" version="1">MSVDEALVRVLTPQVLAVLVRRGADFAAAEDAVQDALVEALRVWPADPPRDPKGWLVTVAWRRFLDATRADVARRRREDLVDEEPGPVPDVDDTLRLYFLCAHPSLTPSSAVALTLRAVGGLTTRQIARAYLVPEATMAQRISRAKRTVSGVRFDRPADVATVLRVLYLVFNEGYSGDVDLAAEAIRLTRQLAAVVDHPEVAGLLALMLLHHARRDARTASDGSLVTLADQDRGRWDTVMIAEGVVILQAALARDRLGEFQAQAAVAALHADAPRAEETDWVQIVEWYDELVRLTDSPVVRLNRVVAVGEADGPRAGLAALADLDPALPRYPAVAAYLHERDGDGTKAARLYAEAAGRAPTLAERDHLTRQAARLNARSGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T867</accession>
    <name>A0A7W7T867_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_005723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15264" checksum="65FD5F6A6A5B36EC" modified="2021-06-02" version="1">MSVKSRLAAVLRARRAQEDMARGAVAKATMELRRAHDVVTDHEDALADHSLPEEADPRAYLAAIAAGRSLASALDQAVSLARSAEVDADTTYDLLRAAARRRRGVEKLVERAAEARRLEELAAEQRDTDELSTRGWEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B4</accession>
    <name>A0A7W7T8B4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13782" checksum="2769AB3B3FCD0B6F" modified="2021-06-02" version="1">MSLRDRFALAVVHVQAVVLATLELFFLPLRLDGTLLPEFHDWPFPVVILLAAGTTPFLVTMAARYATTTLGALSPLLVWLGTLIVLGLFGPGGDVLLLGDLRTLLLFGAGALPAAISVGAFMGRQVRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X1</accession>
    <name>A0A7W7T8X1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor synthesis domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="15944" checksum="F8BB5B80BD548050" modified="2021-06-02" version="1">MRTARVITASTRAAAGVYADRSGPIVVDWLRGRGYEVPDAVVVADGDPVEAALRAAVADGVHVVITTGGTGITPTDRTPEATAAVVDFPIPGIADAIRMSGWPRIPTSVLSRGIAGVAGRTLVVNLPGSTGGVRDGLEMLGTVLEHAVDQVTGGDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y2</accession>
    <name>A0A7W7T8Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030525264" evidence="8">
        <location>
            <begin position="21"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="665" mass="66382" checksum="9D67A3E84303360A" modified="2021-06-02" version="1">MSARTAAVATAGTAAVVVLAAVHLTQGTADTDVLSALFGDARSAAVLAGSRVPRLLTAVLLGVALGVAGAGMRSVARNPLAAPDTLAVNAGAHLSVVTVSVLGLALPTLVDGLAAFAGGLAAAVVVLGLAGGGAAGPRLVLVGSAVALALQSLTILLLLLFEEETSGLFAWGSGSLTVADLDATARMTPVVVLSLVALLLMARSLDVLALGDDQAAVLGLRVRRTRMGAVLLTVAATAAAVTVAGPVGFVGLCAPVITGLLVPRARHLAFLPLSGLVGAVVVLGADVGLRATLGSARALAVPTGVVTTVLGAVVLVWLARRGRSGGTPARAPVGRVAVAGSRRRLVLVGVALGVLLVVVPVVGMLLGDRSVLLGDLANWVRGRTGTALTFVLDQRLPRVLAAVAAGAGLAVSGCGIQSVSRNPLAEPGLLGITAGAGLGAIALITWVPMASAWAVAGVAGAGAVLAFALVYGLAWRSGLESDRLVVIGIAVWSGGSGLITLLIVTSDPWNSAKALTWLSGSTYGRTFEQVLPTLAALVLLLPVLWLRHRELDLHCLDDDTPRVLGVRVERSRLVVLAASGALAATAVSAIGVVGFVGLVAPHLARSLVGGRHARVLPVAAALGAVLVGAADTLGRTVIAPAQIPAGLVIALLGTPYFVVVLWRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P6</accession>
    <name>A0A7W7T9P6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phage-type endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017482">
        <property type="entry name" value="Phage_endonuclease_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03033">
        <property type="entry name" value="phage_rel_nuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29926" checksum="B1EE1DF318504B73" modified="2021-06-02" version="1">MIGLSPYESRFSLWHKKKGLIPPTSDNEPMRWGRILESPIATVFAEQHPDARVRRTGSWVNRARPWQLATPDRLVSLPDERVLLEIKTAHDTTGWGEPGTDDIPVYYRAQVLWQLDTLGLSRAFVAVLIGGSEYREYLVSYAADEVELLRAAAREFLDSLDRGERPNLDEHAVTYRAVRELHPQIDDVEVEIDPALAERYRAAVAEHKAAESTKQRATVELLDVLGRARRAVVDGESIAIRVPGRGAAPPSLRPSPIRSTPQKVSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA05</accession>
    <name>A0A7W7TA05_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="30"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31040" checksum="3E90CE4432BAACBA" modified="2021-06-02" version="1">MWTPIAEEAARATRVLHPDTSSLPKPTRRRVFTVANQKGGVGKTTTTVNLAAALAIHGLKVLVIDLDPQGNASTALAVEHRSGTPSVYEVLIGEMSVAEAAQVSNQSPNLYCVPATIDLAGAEIELVSMVARESRLKEALSAEALEEIQPDYVFIDCPPSLGLLTVNAMCAAQEVLIPIQCEYYALEGLGQLLRNIELVQAHLNPHLNVSTILLTMYDGRTKLADQVTSEVRGHFGDTVLRTVIPRSVKVSEAPGFGQTVLTYDPGSRGAMSYLDAAREIAEYGAEMGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA44</accession>
    <name>A0A7W7TA44_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24699" checksum="D2F5C2624CC9CAA5" modified="2021-06-02" version="1">MVVWERPEPPDRPVPAALSRERIVRAAIRLADADGLDAVSLRKVAATLDVGPMRLYGYIATKEELLDLMVDAVHAEIRATGDDWREVLRSLAETVRRTAYRHEWLADLLGGRPQLGPNTLACGEAAAAGMGDVGLHVAVPAIAAVNAYVIGAVRREITERRAERASGMDREQWQTTYGPYLNRTFATGRFPALAKVVHDGPHLDAEQTFQAGLDFLLDGIAARIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAI2</accession>
    <name>A0A7W7TAI2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="33367" checksum="16D860A00E460C40" modified="2021-06-02" version="1">MRDVAQLAGVSITTVSHVINETRSVAADTRARVLKAVEETGYTGDAIARSLVTGGTKSLGLAVSLVSHPYFAELIAAIESEATLAGYTLVLIDTRGDAESEQAAVRMLRSRRVDGVLLTPTSGSAALPELRRLGVPTVLVDRLTVAQDTDQVGPENVQATSTLVRHLAELGHRRIGLVTGPAGLATTDERVLGYRLGLGRAGLAWDEDVVTGALEPLLGQVSAVVVSDHQVLADVVRAARSGGVRLGTDLALVTYDEVEWAELVDPPLTTMAQPVEEIGRTAVRLLLSRITDPDQAPRTIRLAPELRHRSSCGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB80</accession>
    <name>A0A7W7TB80_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polar amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27343" checksum="012A62DF28BCAA69" modified="2021-06-02" version="1">MTDIAVEITGLKKAFGDLEVLRGIDLTVERGNVVCIIGPSGSGKSTLLRCVNLLEEPTAGKVVVNDVELTDPDADIDKARTGIGMVFQGFNLFSHLNVLNNLTVAQRKVLGRSAAEATGIARRNLERVGLSDKIGAMPAQLSGGQQQRVAIARALSMDPSVMLFDEPTSALDPELVGDVLTVMRQLADEGMTMLVVTHEMQFAREVADRVLFMDGGVVVEEGPAEQVIGTPTQERTKTFLARVLDPVHWEQPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WSZ5</accession>
    <name>A0A7W7WSZ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="43"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28485" checksum="52D524AA271C1EC0" modified="2021-06-02" version="1">MRSTKNPGQPTGITPAAVPVARRTYDGIRLQGVHIGHSAADLAFVVGHGFTNHVRKPYVARVLHRFARHGGVVALDFRGHGRSGGRSSVGDTETHDLAAGVSLAHDLGYRRVVTVGFSMGASVALRHAALDHVPGPAAVAAVSSPSRWWVRETPAMRRVHWLLEQPQGRVVARALGVRLGDPWAVAPESPIEVVHRIAPVPLLLVHGELDHYFAPAHSTALHRAAGGDAELWLEPGVRHAESAMTPALVDRIATWLDRRAEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WSZ9</accession>
    <name>A0A7W7WSZ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-succinyldiaminopimelate aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.17" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009016">
        <property type="term" value="F:succinyldiaminopimelate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="39533" checksum="68A6DC8D741E5F49" modified="2021-06-02" version="1">MTALATRHGAVNLGQGFPDTDGPVSMLDAAKTAIDSGVNQYPPGPGVPELRQAIAEHRSRYGTEYDPDTEVLVTVGATEAIAASLLGLVEPGDEVVLIEPYYDSYAASVALAGATRRTVGLVEDASGRLGLDVAALTAAIGPRTRALLVNTPHNPTGTVFTRSELDAIARLAVEHDLVVITDEVYEHLVFDDASHVPLAALPGMRERTVTISSAGKTFNVTGWKIGWACAPAELLGAVRAAKQFLTFVGGAPFQPAVAHALRTELEWVEKLRISLQDKRSRLADGLRAAGFEVRSSEGTYFITADVRPLGFTDGADFCRALPERAGVAAVPVQVFTDHPEQWKHLVRFAFCKRDEVLDEAIRRLRGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT47</accession>
    <name>A0A7W7WT47_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="52" mass="5338" checksum="39B6F36B0232943E" modified="2021-06-02" version="1">MTPPSALPGRTPSAPPSSIGRLPVRVSRRAPFASAWTALVVPDPRVSKGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTK7</accession>
    <name>A0A7W7WTK7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">F4559_000573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_053719541.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9445" checksum="9735B18DBC1B5359" modified="2021-06-02" version="1">MDWRHRAICRDEDPELFFPVGNSGPALLQIAEAKTVCRRCPVVSDCLSWALESGQDAGVWGGMSEDERRALKRRNARTRARSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN9</accession>
    <name>A0A7W7WTN9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="129"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="35751" checksum="895F8019B085B2D8" modified="2021-06-02" version="1">MTSAVEKVSYWLPRPLDPVRSIKLKLGLALVGSGLAAFGYFRYQAGWLPTRTTLAAMVVGLVTSQFLAHGMTRPLREMTAAARAMRRGDYSRRVRATSRDEVGELAGAFNQMAADLSAADRQRRELIANVSHELKTPITALQNVLENIIDGVSQPDTLRTALAQTERLGRLVTELLDLSRIDAGAHPLDLAEFDVEEFLAAVVAEASVSAQRARFTVSVSPPGATAVGDRARLHQVVANLLDNADRHSPPGGEVRVRASVGTELVLEVSDDGPGIAPEDRERVFERFTRGGRAAGGGTGLGLNIARWVVDLHGGTIRVVDAPGCVIRAVLPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK5</accession>
    <name>A0A7W7WUK5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="930" mass="101506" checksum="3AAEC8B6796B6912" modified="2021-06-02" version="1">MSDRKQAAERQFVDAYHMPEGMPRHEALERAARTADDCDHLPLGVSCRIALLRSSHDLGRYDLMLPAFAWLGTAEQRDASAFDEWEVHNYDWAHKWIVHGLLGDPRFSRAQIDSVVAALEDRYRRHGFSMQPVHGARTDVAESLGDAEAYREHFARYLATERGPMSDCEACVIEEQAGHLIRQGRYAEAVAHAEHQLERDNGCATQPQGILTTLTPAFVALGDLDRARDAHVVAHRLVRDDEAGPYLSDHLEFCATSGNVRRGVDLLQRHLHRVHHSPSPSQAMYFSAAAALLLSRVDFPVEFAVPRDGVTTSTSATALRAALEARAVELAARFDERNGSSATGDRVRAILTAADTVPVPLIVPVPSLVVPPIEEPPVVADPVELAERMAEAFDQGDFVTGIRMLRSLPAELDPLLPEHLAALVAVRRALVEGHGRQRDEVLAEVDSALDRLRAAGEHDLANRFLGRSMTLRLDTLGHDACVERLRACIAEADRSGTPYSRVLLRLLLADVFGDSDDSEQQSELILEAAALAEESVPELVSRVRCDGAQLQASTGELDAAYSTVTRLLASSPGPSVRFDALRLKVKLETVRGDEAAMDTAELFVADFASPRGPWVAETHRQRVASVERLGLEGDYLPQLRDAVAVGHDLGVPDDVAKACYALAGGYLKGNRFVEAAEALEEAVRILESAEVDPDIVVPVRYRLGQTCARLGELAEARGHLETALGLVDESEPWRMALVLDVLGGVLRRQESPNEAAAAYARAARCWQEVSEAAEAAGSWVESASALPEEENQACLEALEAATALLPEVAEEHHRTHLTARVAAIRAFVHTRMGEFAEAIERNTVAEELAAQLDDADWRTFLVARGARFHLDSGDPATAEAEARRAATLMTDQTPHQILGDTAAVLEESLRAQDKPTADPLLRALTARLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN4</accession>
    <name>A0A7W7WUN4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20409" checksum="9D83B47E895DD3C7" modified="2021-06-02" version="1">MAVHLTKIYTRVGDDGTTGLGDFSRVPKTSPRIAAYADVDETNAALGVVLALGSPADDVASVVLKVQNDLFDVGADLCTPIVPSPEYPPLRVTQAYVDRLEGWCDEFNSGLPKLDSFILNGGTPAAALLHQARVIARRAERSAWVLLESSPEDTNILTAKYLNRLSDLLFILARVANPDGDVLWQPGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ3</accession>
    <name>A0A7W7WUQ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031300252" evidence="1">
        <location>
            <begin position="28"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="23869" checksum="667DD50DF0813776" modified="2021-06-02" version="1">MRLTRLIPALAAAAMAVLGFAPTAATAAPAGDVTPYIIGGGYATSAPWAARLFSNGQQTCTATIIAPTWILTAKHCVSGGNLSFRIGSLDQTSGGTVANGAQIVNHSASDLSLVRLDRSVSATYIRLGAAGSVTVGQSVQVYGWGATSQCGSEINCQSQRLKVATVTVTGGCTDAYNGSAICARRGNGITAGGDSGGPMVANGTQVGVASTSDRQTTTAYTNVTRYRSWIQSVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX3</accession>
    <name>A0A7W7WUX3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="7" type="ORF">F4559_001262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030702967" description="50S ribosomal protein L32" evidence="6">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6751" checksum="A42D0174B6B3A814" modified="2021-06-02" version="1">MAVPKRKMSRSNTRSRRAQWKTSAVHLVACSNRACRQPKPQHVTCPSCGQYDGRQVVQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV06</accession>
    <name>A0A7W7WV06_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16018" checksum="CF066B6D3789DBF9" modified="2021-06-02" version="1">MSVVTAVQFRPRRIRTVSVVCAVFLVAVFTVVGLLLGDSPTGVIFRTSDQVAMICLGVLLAGGVLLLARPRVRADERGVEVRNVVTAHRYEWTDVLHVSFPDGASWARLELPDDEYVSIMAVQAVDRDHAVAAVRALRDLHRAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV14</accession>
    <name>A0A7W7WV14_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">F4559_001397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16131" checksum="71BDAB6B7158EC3D" modified="2021-06-02" version="1">MADQARARKLAKRISQIVASALEHEVKDPRLARVTITDTKVTGDLHDATVYYTVLGEKLDSPPDLAGAAAALEKAKGVLRTMVGQQTGVRFTPTLSFVTDTVPETARQMDELLAKAREADAEVARLAHGARHAGEEDPYKPPREAEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV37</accession>
    <name>A0A7W7WV37_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 2 lantibiotic biosynthesis protein LanM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04792">
        <property type="entry name" value="LanM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025410">
        <property type="entry name" value="Lant_dehyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017146">
        <property type="entry name" value="Lanti_2_LanM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13575">
        <property type="entry name" value="DUF4135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037228">
        <property type="entry name" value="Lant_mod_RumM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03897">
        <property type="entry name" value="lanti_2_LanM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4135" evidence="1">
        <location>
            <begin position="128"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="951" mass="101674" checksum="CEE65EF5DAF5B244" modified="2021-06-02" version="1">MIPSAVARPLTAWWHAGVRDVESAEPPDWVDFVESATAAPAHWSGDDWVDAFAFALRALTAKAAADPRLDAVFTERLGRRLARTAARALVLELNLRRIAGELRGRTSRERFADFVDRLDLHAFLRRHPVLARHLGQTCLRAAEAQLELLDRLDRDHDDIVATLLHGTDPGPVRTVDTGRGDAHQGGRTVAVITYADGRKVVYKPRPVATHVAFEALLRWFDDHTGLGLRVPRALDRGDHGWLEYVDHAPCVDVTEVGRFYQRLGALISLLYAVDGTDMHYENLVAHGAHPVLVDVETLFHPTVGIPADPAVKALARSVHRTAILPRVLLGEHGALDIGGVGGDHGDRLPADGVAWLHPATDRMRLVRRPVPVPPAVNRPVLDGLIAEPADYRGALLAGFRTGYDALFDHRDDLLADDGPLNRFAGLPVRFVPRMTQLYATLLDESTHPDALSTSADRDQAFEALWLDSDLPLMRALVPHELADLWAGDVPLFTTTPDSRDVSASHGAELVDLLPISGLDAVRAKLRELDEVDRNDQQWLISAALASRPRPVEHRTGTPLPGPVAAGVPDPQRLLVAACGIADEVLAHATADGDRVNWVGLELVDDRHWAVAAMGAGLSTGYTGVALFLAQLGALTGAERYTAFARAALTPVPALLEAFAADTDLAVAVGPGAFHGLGGIAYALARLETLLDDPAIGGWLARAVTIAADTVDDDGANVVEGLAGGLASMLAVHRESGQAAAGRLAGAYAERLVTATAAGDGFARGRAGVGWALLRYARESGDHRFGPPGRAHLRADHALRQRLLDVAEADHSWCSGLAGAVLAHTAHPGCPVDTYTPHLDRCLNALAVHEPLRDLSLCHGELGVVESLAVTAERGHDLAAATLTRRAGLVLGALEEFGARCGTPGGVPSAGLLTGLSGIGYGLLRLAFPERVPSVLLLETPESPYRHEENDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV74</accession>
    <name>A0A7W7WV74_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_002373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="243"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4965014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="555" mass="60751" checksum="8DC7D088B71DB835" modified="2021-06-02" version="1">MTDAPDDRTSFAELGLRPELLRALSGLGYEEPTPIQSEAIPPLSEGRDLLGQAATGTGKTAAFALPVLERMAKGERTERAPFALVLVPTRELAVQVSEAIHRYGRELGARVLPIYGGQPIGRQLRVLEQGVDVVVATPGRAIDHLNRGTLSLDHLEIVVLDEADEMLDMGFAEDIDAILADAPEARQTVLFSATMPPRINRLANQHLKDPVRITISREQTEPGEAPRVRQVAYVVPRAHKPAALGRVLDVEAPTAAIVFCRTRDEVDQLTETLNGRGYRAESLHGGISQEQRDRVMARLRNGTADLLVATDVAARGLDVEQLTHVVNYNVPSAPESYVHRIGRVGRAGREGVAITLAEPREHGMLKTIERVTKQRIQMEKVPTIADLRARRLELTRAALHESLLEDELEGFRVVVETLADEFDVMEIALAAVKLAHEATGAASDEEEIPEVAPRTDRRGDGAPRRERRSRPPTAGMTRLFVNAGRSAGIRPQDLVGAIAGEARLNGREIGAIEIADRFSLVEVPENAAQQVIVALRGATVKGRKVTVRRERDEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB2</accession>
    <name>A0A7W7WVB2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25616" checksum="171FE737582074C9" modified="2021-06-02" version="1">MTTALLLAHGAGGAARPNFGPLIPALSRTRRVFAPDLPGSGTTPRAAGPLELDDLADFLIAAADTDTVDILGYSLGCGVAVRAAVRHPDRVSRLVLTSGFVRADDHVRERSGRWRELLAGDRDELARFVMELVLGDPFRHAMTPEQVEGFLEIIQLTLPPGVDEQVALVQRLDVGDDVAKVAAPTLVIGTRHDNLVRPAASRALADAIPDAEYAELDSGHAPALETPKEWLRLVEGFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ3</accession>
    <name>A0A7W7WVJ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional repressor of nem operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20061" checksum="70CD1CDE680EFB44" modified="2021-06-02" version="1">MGRRKEFDPDEVCAIAVEVFRDHGYEGTSVADLVDRLGVAKASLYSTFGSKHDLYLAALDRYVADTDATIIADLAQGDPDEAVKHLILRYARESRTSCLVVSAATELLPDDHRVTALVEKSWHTLRTALTLAFTRAGHEDADGRACLVLAFLQGLRVLGKGDGKTVRTAVDTFLKLIQTERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN1</accession>
    <name>A0A7W7WVN1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="17650" checksum="3DEBC0C865FBA3E0" modified="2021-06-02" version="1">MTALLPVSGPGTEQDTVVYVVVFPEGLLVVRHAASGCEPLDDEDVPPYQAGLWSAVADDVDPDRHEVNGIALDGDLRAKLADAADTTPAEYSDNPVATRMPLALGAEPQPRRGAVAIVAEEDPQTGLTGSLSAGQLALIVQTHQTALLPATGRSRRKQIAREVPAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY4</accession>
    <name>A0A7W7WVY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="778"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="822" mass="83212" checksum="9C6DD8EFD102E07D" modified="2021-06-02" version="1">MPTSLRLAVAEFRERPGRSVLPGVALVVGVACLSAALMLSDAMVSATARGASTVPAGVSTVVRPTSDGEVALDAAVLDRVVAVPGVRDVVPVRQVRADLLLDGGRAGAGRAVAEIESTREDLRRVPIGEGRAPGADGEIAVDRVTAYRHGLAPGASVRVADAEGRPIDVVVRGVTVRGGFGNEPLIVVGEELAAKLGGRPEITALYVFGGDRAAVSAAAGAGMRAQAAAVVSAERPGNELMIVLLPFSILALATSVFVASATYRAVYLQRQRHTALLRCLGAHRGPLVWANLIEAVLTGAVAGALGGVAGGSVGWLLARLFDAAGLSEVLGAVRLDPPLLPTAGQFALGVGVAAVLSGFAAVRPSFAAVRVAPLAALRTSEGQTPDRAVVRRRYVFGVVVVGFAAALAALGLMAGGIGAVFLVLFSCIAAVGGLFGVLGPVVVPALGRVFGVLAGRIGGAQWRLAAAEVRRVPQRSASVAMPLLLAAAMVTFFAVTVGAVRTVEDKFEDEPRPDAVVVDAGHRVVDAGTVAAVDRPEVRSSLVVHTAEGSRQVRGEPAPYQVLGADPERLRAWLADRGTAVPGFGAGSVLLSEWLVEEFGARVGQPVTLDGVPGGPVTGTFTGTIPFELLDGANAVVGATGFAPASKVLVTLRDGADPAAFRAGVLDALGSAPTVLVRTRADVTAENQRMIDIGITTMMVLLGLSVAVAVTGIGTALTISVQERRKELALRRALGVTRGGIKLGVVAEAVLLSLVGVVGGGVFGFAYAELTLMSLGVFAVPSVALVPLLVGGVGVVVLAVLSAFGPASGASRIRPAAGLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW11</accession>
    <name>A0A7W7WW11_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HAF family extracellular repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="40231" checksum="EE2EF7E0B3348D0E" modified="2021-06-02" version="1">MTGHVGVVVCVSALLVAADDATGIVDLGLGHAAAIDDRGTVVGWDGSGRAVRWDVSGRKTVLDVLPGHTTSWASDIDRHGNVVGTSARRDAEGRTLARHAVRWDRDGRVFRLAGLDGRPVGTAVAVDEDGVAVGTASGPDTGVRAVRWDQARSGDRPRRPAGVRVVDARRHRRRCGRRQRLHGGDGVAGGPVGRRRADRRPGCPAGRRPERCLVRRPGRYGGRVLDRCRVRASCGVGSGRARHRVVGPARRCARVAGGDRRRRHRRRRLHHGDDRGVRAVRWDRHGRVTGLSTPPGVGSTAATAIGDRGVIVGYGWVDDRTTHALRWDRDGRVVDLGLLPDGTYSTASRVNGRGVVIGQAGKADGDHAVLWRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW43</accession>
    <name>A0A7W7WW43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="10"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="35761" checksum="638446FDF54DDFA7" modified="2021-06-02" version="1">MTVGLRGPVPGRTPMLNAEVRYRGRTTNLWLKLEQENPFGSIKDRVAFSLIGSILRAGGPRAEIIESTSGNLGIALARYAQICDIGFTAVVDPRTSHKLVRQMRSAGAKVVEVTTPDETGGYLLSRLDYIRGRAAVEDSLIWPNQYENPANPRAHAQGTAPEISHAVPDGGLDVFLGVSTGGTFRGFTDYVEENRAPWRCVAVDEVGSVALGGRPAARDLNGIGASRTSTFVADHDVPTVRVTAAEAVAACDWIASELGVRVGGSSGAVVAGAVRWIREGHGAEHVVVVCADGGDRYEDTIYSPAWRRAKNLAWKTSLEFPEVRTTRVVEGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM8</accession>
    <name>A0A7W7WWM8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8809" checksum="E7DEC61FC5A55397" modified="2021-06-02" version="1">MELFCCFLGKPGGGAECRRRFVGSVHHDAHNVEDLAQRRHTEPPNRTLNDAGTAHRNSVRIPTGTTSDQPRWKVGVDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP9</accession>
    <name>A0A7W7WWP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="7452" checksum="2CACC72FBF7DC35F" modified="2021-06-02" version="1">MISAALVATAGPGPAFAPVARATGFSTVVGLAAAPLGMALAGPAAERVGPDAVLLVGAVVAVLSAPLALAVRSVRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR8</accession>
    <name>A0A7W7WWR8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="166"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="45838" checksum="6035BF8B1F2C2380" modified="2021-06-02" version="1">MIVEPVQPSDPRPGEVVASPAVGESELRALERLLHDWLSGYSSAATRRSYGDALGLDRRWVEAIGGLPGPRAARSTPPTRPGRYRDWAWLRWCDRNGVHPLRADSAAVKRWQLELGAEGAPKSTRAHRLSAVGAMYAYLAEHGAVTVDPTRFDRSRLGLGSHRDTSPTVVLTAAEVDLLLRTAATPRRGVHAVMRYRAVAIVALLTLGVRIGELAALRRSDVHTTRGRRALRVTGKGDKIRIVYLSSLAAGALDDYLAERDRWSAAAVPTLPGRVRGQLSPLVATRDGGPVDPRDMWSLLRRLARGAGPGLADVADRLGPHVLRHFYVTTAAEAGAEMTHVQADVGHSSVDTTNRVYNQAARAPERSAVDVVERVLLQARNAGREPGELDRLKAEIARLSTAEETTESLRTALRALLDTQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT1</accession>
    <name>A0A7W7WWT1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F420_oxidored domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="1">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="19915" checksum="59278325F1C46847" modified="2021-06-02" version="1">MRIGVLGTGGVAAALGARWVAAGHEVVIGGRSVERARALAVRLGASAGGSLADARSHGDVLLVAVPAAVAVEVLGHVPGRVVVDCTNSVVPGRFVLDRVGQARSLGASGGDVVKAFNLHHVSTWDIPAPVYGGVPLGVPICGDSSRALDLVAELVRAVGCVPVLAGGLERAELLEATAAFAIGLWFGGHDVRALFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM9</accession>
    <name>A0A7W7WXM9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malonyl CoA-acyl carrier protein transacylase/acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="421"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="503" mass="52925" checksum="B92A26194F6EAC39" modified="2021-06-02" version="1">METSIGLLPGQGSFRAGAVDVLLADGVARAELATVDEVVRETLALHLLKSTTGTDRLGEDELYATEPDLAQVAGFATSVALAALLRSRGASVSVFAGHSLGEISALVCAGALSTEDGAWVLAQRIAVLREVDTSGGGMLALSCERDRVQRILELLPTRDVVVAVDNGRRQTVVSGPADSLRRVERIGSALGVPVAALRAPHPFHHVLLEPARVAFAEALRGIRTSIPHTPVFSPILGRYYRPREDLSESLPAHLVHPVSFGPTVDRAHRDGTRVWVELGAGRTLTTLVRSAHPADTVLTPLHGGPDNLTRTVEFLTTTPPVPTLATRVPPAHSAAVGTDGATTADLFPTTLPAPFPRPASGPAKALSAPVTRPAAIDVAGAPLAPATVPARADAVRAAHQTTDTVGASAPHAPAALPHPAPTAEDVESRIRRMYATALEYPEEVFESAAELEADLGVDSVKQTELMNRLGQEFGLGPRPDRARVGDYRTFGQVVAFVREALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY43</accession>
    <name>A0A7W7WY43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tfp pilus assembly protein FimV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="16817" checksum="D63AABBAA9C63833" modified="2021-06-02" version="1">MAVVIGTRDGFELVEHDGVGVPPGPRVVRRFAVTDTGRPAAESRPATAPEPPRPAVPADRTRRTGLLRLLAYGVLTAVISACLALTYGYVSGAMTVPERTSVVYVQAGETLWDVAARSAPDSDVDAVVDRIRELNHLTSDEVLPGLALVVPDGREPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ5</accession>
    <name>A0A7W7WYQ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5092" checksum="1FB196B1F6C6B2AA" modified="2021-06-02" version="1">MPASPATTLLGTRLLVAAAQAACGNGQDGHPLPAFVPPVCLVPWMGHALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY0</accession>
    <name>A0A7W7WYY0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RHS repeat-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="2">
        <location>
            <begin position="2022"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2078"/>
            <end position="2100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2171" mass="234240" checksum="6DF83AE55DE32B7C" modified="2021-06-02" version="1">MTGQETTPIAPDEAAKRALTGAPAATWPSAGEGAAELSEGGSAEFRAGDLPVRVEGRTGDVRVRLLDRAEADKAGVSGPLLRVSGAEGPVTVAIDYSGFRHAFGGDWASRLTVVQLPDHTPVESHNDSTLGRLTASFSLPGESGRTFAGSAAPGGEILLAVTSSGTSADGQGDYAATPLKPSATWQVSQQTGDFSWSYPIKVPPVPGGLAPSVALGYSSSTVDGHMASTNNQPSWLGEGWESWSGYIERSFMSCADNTDEPAKKTLDKCWFDDNATLMLNGSGGKLVHNEDPANDYWRLKNDDRSKIERLTGATNGDVDGEYWRITKSDGTKYYFGLNRLDGWSAGKPETKSTWTVPVFGRLSGQPCYNATFKDAWCTRAWRWNLDYVVDARGNSMTYYYDTETNNYGRNRNETASQYVRGGTLNRIEYGTRAGQEYAGEPPAKVTFDTAERCAPNTGCSQATATDFPDVPLDQKCDATTCPDKLSPTFWTTKKLTKIVTKARVGSGWQDVDSWSFNHSFPETGDSSSAALWLTGIVHKGHVGGEITLPEVTFDGKRLANRVGSPTAGWGGYLPLYKYRLTKIYSEAGGLVALDYFDGDCDRAALPAADDTNGTRCFPVKWAPPDHSEIDDWFHKYPVREVVETDRVGGAPDQVTSYEYVGTPAWHYTDDPIIPEERRSWSEWRGYQKVRTTKGNTQTERLYYRGMFGDKKAAGGTRTDKVIDSQLGEADDIPAAQGFQREEILKSGPGGATLLTTITTPWTRGPTAKRGPIEAYMTRPASTRTITTLAAGGTRSTKAVNVYNDDGVAIKFDEFGDESTPNDDMCTETTHASNTTAWILDLVVEVKKYGAACGGVYVIPAGIIGYSRNYYDGSTTLGTVPGAGAVTKSEEVAEYSLGVPQFKQVSRAEYDNYGRVTKSWDALDRKSETTYTHTNGLLTTQSVTNPKNFTASTTFNAAWGSPTVKTDANNGTTRLGYDALGRLKTVRMPGRGDNETPNIEYGYTIRKDAVSSVSTTTLNAHDAQSTSYAIYDGLLRPRQTQSPAPYVGRQISDTFYDSRGLVGRTATLYYDDDAGPGPELVTVPAGNQPDLPSQTLTTYDALARPLTQTFRGLGQDKWTTTKVYGGDRVMTTPPAGGTATTVLTDAQGRTTELWQHKAATPTGDKDVTRYEYSRDGKLLKLIDPAGNFWRNTYDLRDRVVTVEDPDRGLTTNTYDDAGQLLTTKDSRNRTVRFEYDELGRKTASYEGTTKLSDWTYDTLRKGDLRKSTRYVGGNAYSSEVTAYDGSGRPTGQKVTIPTAEGSLAGSYETTTGYGHDGSVVSVALPAAGNLAAETLQYTYLTTGEQESLGGTTDYVPEVTYNEYSQVSQIMLNAGVSQGSKWVQLNRGYEADTRRLSDSTVVRHVTGNGVASRSKYFYDPAGNITSVVEAPTNFTTDASGTITSLPNGLPSSVDYQCFKYDHVQQLKEAWAGTSKCAANPSLQVVGGPAGYWQSFTYDAAGNRATDTEHTAAGDTVSTYALPQSGGHLLQSVTSNGPSGQQLQTFEYDQTGNTKKRMANGVTHDLVWDAEGKLTSDTASGQTTSFVYDAEGSRLLRKVPGEVTLYLAGQEIKLTTSTNQKSGTRWYSIAGTTVAARTSSSLTWLAGDHQGTNQVSLNSANLAVTQRRQTPFGESRGTAPASWPDDKGFVGGTNDTTTGLVHLGAREYDAGIGRFISADPIMDLTDPQQINGYAYGNSSPITFSDPTGLKRCGVDGDGCGSVPNRDSYGDRGSTGETAYEYHQRTENEKKNAYAAAGVSEQDIIDAEQVEKQNWLDIALEAGGEILKEVLGINDIQSCFGEGDLGACASMILGAIPWGKILKAPKIVKAIDNAIGAVKSFMKRQDWAKNVLGRGRAALAKITGGGCKNSFTPDTEILLADGTRKALKDVDVGDKVKATDPETGKTEAKTVANVIVGNGKKYMVDVTVEVDGVRSTISATGNHPFWRTDEDRWVRADELKPGALLETAEGRQVDIVEVRPWSAVRQVFNLTVEGIHTYYALTGVTPVLVHNTSCDISKAAAELPTDYPRRTTGILDVGNEQIPLSSGPGGPSEELASLPGRTKQNSDHVETHAAAILRSNPVIRKAVLYVSNSKGQMCPGPNGCAANIEDMLPEGVEMWVYMNGLPFGKFIGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY8</accession>
    <name>A0A7W7WYY8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20301" checksum="4A199EB0C4F60E66" modified="2021-06-02" version="1">MRRFTDVVRFGWAVTVTGALLGLAVAVGVWFQDRLCFGTTQGAALVRAGTTTTHIAANEVSLCLPDPTGVDRLFGSLVWAPTLIAYAVTFHLLLRTTERALREGPHSHATARGLRTFGWWLLLGPLAVSAVEFGSVLALVRSAVGELGPVSLRDWHVPWWAVVTGLGIVVLAGIMRTGAEMRLDLEGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYZ1</accession>
    <name>A0A7W7WYZ1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lig</name>
        <name evidence="16" type="ORF">F4559_005835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="290"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="12">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4968476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="505" mass="53659" checksum="CA8EB2BF1BADB991" modified="2021-06-02" version="1">MLFSEVVETSAAVAATRSRLAKVAALAGLVRRSTTPAVVSFLVGAPSQGRVGAGFRTVFDLSVPPDGEATLTVSDVDEALGAFAGISGKGAAGRRAEALAGLFSRATESEQDFLRRLLTGELRQGALEGVMLDAIAKASDVPGEVVRRAFMLSGSLSETASAALSTGVEGLSAFRLQVGRPVRPMLASPAASLPEALAELGSCVVEHKLDGARIQVHRQGDEVRVFTRTLREITASVPELVELVRGLACDSVVLDGETLALDDSGKPRPFQETMSRFGAQDTRELLLSPFFFDCLHRDGVDLLDEPLRARLAALRDIAGEHVIPGLSDPDGDRAAAVLDEALDAGHEGVMVKSLESVYAAGRRGRAWQKVKPVHTLDLVVLGVEWGSGRRKGLLSNLHLGARDPDGGPPMMVGKTFKGLTDELLAWQTRELLAIATDKSEWVVEVRPELVIEIELDGVQTSTRYPGGVALRFARVVRYRPDKDAAEADTIDTVRALSHKAGGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ05</accession>
    <name>A0A7W7WZ05_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="439" mass="46955" checksum="FBDD8450515B69E4" modified="2021-06-02" version="1">MTQPPQPGGRPSPRPVGPPPVPAPLTPRPTRPYPMPPPQNQPGPYQQPGPYPQQPGGYPQQQPGPYGPPQPGYQQPWPQMPPRAVMPPPVPAQQPGWGQQPPGWPQQYQPYPPLRRKSNSGPIVAAVIVGVVVLGIAAIGVFASLTRHKTTDDASYSGYSTYTYSVAPTTTTTNRTTTQSTTRPSATTRPSPSTTAKAGPKAVVALGDNPIHGNDLGAFDIDGCALPPMDYSVAGQERFLRAALPCIEAMWKPSFTKANLPYQPVELTMVTSQVTNACGTVSPDRTAVYCEGGIFWTPLHYSGETGNANPNHPGKYLGQLAHEYGHHVQWLSGILRAASQAQYDKGGWDTPAGLELNRRKELQATCFGGMTLAPLSHGAIPTDVIQVALTDAGNRGDYPVYPNRDHGAPERNAAWVQHGYKNNSTSACNTWTASAADVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ44</accession>
    <name>A0A7W7WZ44_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombination protein RecT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018330">
        <property type="entry name" value="RecT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004590">
        <property type="entry name" value="ssDNA_annealing_RecT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03837">
        <property type="entry name" value="RecT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00616">
        <property type="entry name" value="rect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="30583" checksum="1D57E2A50E7349EB" modified="2021-06-02" version="1">MTAQTVTNAVATQTAAQALIGQYRADFAQVLPSHVKAATFVRLSQGLLRRNVKLAQAAERNPASFLAALLECARLGHDPGTDAFALVPFNDRRNNTVEVVGIEQYQGVIERMYRAGAVRSVKAEVVRARDSFAYEPDVMDRPRHRPDWFADDRGELIGVYAYAVMLDGATSRVVVMNRAEVMRHKSVARGATGDDSPWQVWEESMWRKTAVHELEKWVPTSAEYRETLRPDRAAEQETTNVPPARSADDVVDAEVVDDTTPQREPATTSTTRGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ58</accession>
    <name>A0A7W7WZ58_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="318"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="525" mass="55233" checksum="7A17B1960613EBB9" modified="2021-06-02" version="1">MAFARRRLTWALASLLPLAFLGVFFLWPVVAIVGLGLRDGVQVDADTWGLVGFTLGQAAAATAVALVAGLPVAYLLARCRVRGTGVVRAAVMVPFVLPTVVVGLAFRALWPDGGVLPIVLANAFFNVAVVARTVGGLWARLDRRVEDAARSLGASRLRAFRSVTLPALAPAIGSAAAVVFLFCSTAFGVVLVLGGARYRTLETEIYLRTVQLLDLSGAATLSLLQFAAVIAVLVIGVVTRRRRERGLPLRVEPPRRPGGGEWVVVGAAWLVVGVLLVPVVALTVRSLSTVDGWSLAGYRALAGTGERGTLVVSGLDAAVRSLRAATDATMIALVVGVLSAVVLVGLRRSGSWFAETLDTALMLPLGVSAVTVGFGYLITMDALPGDFRTSPLLVPLAQALVVTPLVVRIVLPVLRAVDERLRQAAATLGASPWRVWREVDFPLAFRSLVAAAGFGFVVALGEFGATSFLARPDAATLPVVIARLMSRPGQLNSQLAYAACVLLMVVTTVTVLLIERLRVPSSGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ94</accession>
    <name>A0A7W7WZ94_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat</name>
        <name evidence="5" type="ORF">F4559_006421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="25"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="37717" checksum="4FC38526542152CF" modified="2021-06-02" version="1">MTVRTRADLSSLPGYVPGRSIPGAIKLASNEVSAGPLPSVVRAIADAATAVNRYPDTAATDLVARLGDKLGVPNEQIAVGCGSVTLCQQLIQSTCTEADEVVFPWRSFEAYPILTSVVGAAGSRVPLTAGHGLDLDAMADALTERTRLVFVCNPNNPTGTALRTEEIERFIDRVPEDVLVVIDEAYKEFVDDPHVPDGVELAKTQWARGRDNVAVLRTFSKAYGLAGLRVGYAVASPAVAETLRKVYVPFSVNALAQAAAIASLDAEDELLVRCRAIVAERGRVRSELIAAGYEVPVSQANFVWLPLGARTDAFNEHCLAHKVVVRAFSGDGARVTIGEVDENDAFLAAAKAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X027</accession>
    <name>A0A7W7X027_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16816" checksum="D6746EB1E7079DD4" modified="2021-06-02" version="1">MLLAAMAAARKGERWTAQDRVRSVEPVARRTGERNTLWTAFGPTNVKMFAVAVAVEAGAAAEALRLAEQIDHHHSPSLERRVAFLIDQAKGHEQRRDYASALVMLTMAEREAPEDMRHRPAARGLLDTLVRRGRRTVAAEAARMATRVGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X029</accession>
    <name>A0A7W7X029_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25307" checksum="FE9CF496C120AA7D" modified="2021-06-02" version="1">MTAGLLLLVVVLAILGVGVAVGLSRRKRNPFTNQAFVNEWEQRMRALEASLGWRFVAEDQGFQERVPQIGRMLEADRSRVKFQLVGSWRNVPVLAVEVVLRTDNVVTQEFRTYSVVVVPRPMPGPWVLISPRADSVWGLFEQFVPSGDAEFDARYEVRRKNPAFAGALLGSGLTRALLVDPRAAGVALAFDEHNLAAAVPVPLVRAPLGHLADLLLDVSARVPWQGLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXA9</accession>
    <name>A0A7W7SXA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein YqiK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="665" mass="74094" checksum="4006FF215885115D" modified="2021-06-02" version="1">MGVISTGLGILIAVVLFILIIFLILFGRLFRKIEQGKALIISKVRRVDVTFTGAMVLPVLHRAEIMDISVKTIEIRRAGTEGLICRDNIRADIRITFFVRVNKTVEDVIKVAQAIGTQRASDVATLQELFNAKFSEALKTVGKQLDFVDLYTKRNEFRDRIVQVIGTDLNGYSLEDAAIDYLEQTPMAQLNPTNILDAQGIRKITELTAIEHVRTNDYQRGEEKEITRQNVEAREAILELERRQADAEIKQRREVEVLRAREEAEIETVRAQERLKYETARLRGEEAIGIQEENKSREIAVAEKNRERVIAIETERIEKDRQLEVIGRERETELSRISKDKEVEGEKRVIAEVVRERIAVEKTVAEQEENIKRLRAVEEAERLRQTIVIGAEAEAQESLVKDIKAAEAAEEAAKFKAREELLLADARRQAAELDAAAAIRLAEGRQATAAASGLADVQVRERNAEAVEKLGRAEAVVEREKALVAAEAIREKLKGEAEGLADKATAMAALDEATREHEEYRLRLETEKEIRLKGIDAQRQVAESQALVLAAGLEKADIDIVGGDAMFFDRIVGAVTLGKSVDGFLEHSDVAQKLVKPWLNGSGDFTQDITRILGSFGTEDLKNLTVSAALLKLINAGGPDEGRLRELLAMAQRLGVAERPIAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXZ8</accession>
    <name>A0A7W7SXZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5292" checksum="AB47E170B6193683" modified="2021-06-02" version="1">MRMKPTAPRSATTLPSHAVVPPMTPGQFVREIGEWLAVDPSTVDKMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY13</accession>
    <name>A0A7W7SY13_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="24735" checksum="C83D0F9745F9E855" modified="2021-06-02" version="1">MTQLHDNQVPVVTRPQRFGALAWTALILGIVGLMGSPIIFFNNLTAIAAGVGVILGVIAFFGTKKILAAIGTILCVGAIVVTVSVQSTFVEKLDEIVQGTTSPQVTPLSWGQRHTWDDGLAVEIATPIACTPGEYAQPPNVARATKITVTVLNGTDKPFDTATLTVGSDAQFNGKRAEQIFDTDGGCGGGFEATTILPGKTYTYEAAYSVTAETGELQITLQPSFTAPKSIFTGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY69</accession>
    <name>A0A7W7SY69_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031498584" evidence="1">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20722" checksum="7B3A38784CA2C70D" modified="2021-06-02" version="1">MRITRMIATALPALVVLACTPSAQDRPSHLDDPLPAITTTPLVLPARPAEVRLDDVDPCGVLSQDERLRLSLDNPPTAYVEPAFGNAKACTIRSTISGNVLRLALVTEQGVDVWLDENAQVEAQVISVAGYPALTVRTPGLEHLCTVEVDVAKGQFLDVMFRDGGNTTALPQDTLCLGAERAAEAAMAALLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY88</accession>
    <name>A0A7W7SY88_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="3">
        <location>
            <begin position="320"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="515"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="576" mass="61950" checksum="9321D46E09F74520" modified="2021-06-02" version="1">MTDEELAEIVGNLRALGSDVAEVEAKRAQTGLPRSVRETLSSFANTAGGVLILGLDESRGFFASGVADAAKTTADLGAMCSTEMEPPVRPLIRAHLFEGVTLVVAEIPEADPSLKPCYYKGAGATKGSYVRVGDGDRQLSAYEVQMLISSRGQPREDEQAVVGSSIDSLDPDAVRALAARLRQTRPYAFGDQSDEQVLRDIRALVVDASGAERASLAGLLTLGRYPQGSFPQLMLTFVHYPTEGGADDATGERFVDNVMVEGPIPVMVRETMAVIRRNMSRRAVVTGHGRSDVWEYPETALREAVVNALAHRDLSAPSLGTQVQVEMYPDRISIRNPGGLFGPVTLDTLGAEGISSSRNATLLKILEDVTVPGESRTVCENRGSGIRSMMAALRAAGMSAPRFVDRISSFTVEFPSHCLLGADAVEWIAGLGEQGLTDSQCMALALLRSGQVLDNGAYRAATGLDSRVATVELQDLVTRGLVEQTGTRRWARYRSAATPADRTSVDRPSAWGDRRGRILDALGGKTLSRAELSSATGLSDQTVLHWLRILRGEGVVEIVGPPRSRNARYRRTGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYI2</accession>
    <name>A0A7W7SYI2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme related to lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13734" checksum="5A6E71A38913C1AC" modified="2021-06-02" version="1">MARVTGIGGVFLRARDPSRLAVWYRDRLGVPMSTHGAVTFHWAETETTTLALFAHDTEYFGEPGQRTMLNLRVDDLATLLEQLRAQGVEVLPQTEDSEFGRFGWCVDPEGNRIELWQPAPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT9</accession>
    <name>A0A7W7SYT9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Act minimal PKS chain-length factor (CLF/KS beta)</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="4"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="41847" checksum="70450A22631EE66A" modified="2021-06-02" version="1">MADLVFTGIGVVAPTGSTAEEHWASVLKGQSGITRISRFDASGYPVRYAGQVVDPRVAQAVPGRLAPQTDRWTHLALVAADEALRDADVDPKAVPEYEMAVVTSSSSGGTEFGQREIERLWRDGPDHVGAYQSIAWFYAATTGQLSIRHGMRGPCAVLAAEQAGGLDVLDHARRLTRSGCRLVLTGGTDASLSPYGLVAQLPTGLLSTVDDGAYRPFDVAASGHLPGEGGAILVAEEASAARDRGHDRPYGVLRGHAAGFDPPPGSNRPPVLERVLRAALSDAGVWPSEVDVVFADAQGTPAADLAEARAIGAVFGAHGVPVTAPKTLTGRLYGGGAALDVATALMSLRYGVVPHTAGVERPVPAYDLDLVLDRPRERPVRTAVVLARGYGGFTSAVVLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV6</accession>
    <name>A0A7W7SYV6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="7989" checksum="69AA7F845E94873B" modified="2021-06-02" version="1">MDTSRRIVAVVVAVDSPAGRVVEAIDDLAAHLPGTDRPQDCPLCSWHPPPTSRPSSRVGPERRTDPWFAAGSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ05</accession>
    <name>A0A7W7SZ05_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15695" checksum="32F5ECE9E5C36D22" modified="2021-06-02" version="1">MSQDDVEWSHETVVKRLASEMFRGALVATLVTVGVCLVVWTVVEGLPGLLAALVGGLVACLSSIATLVLMRKTAALPVQFIMVAALGGFMGKLIMLVLVMFLLRKFPVLHVNALGITMAATILVATFMEVRASKRSRSQMVVPTPGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ18</accession>
    <name>A0A7W7SZ18_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="33111" checksum="84F3A279095A0D06" modified="2021-06-02" version="1">MTCAFSTRLDTVAEAIRNGDLRTAKFHTTRLLADADPHTSALIAACVDTIERFPRRAVVHLRARWKAATTDDDRAVIAAFGQAARPAPEPPTIRRSHRTAPRDLDTSGRTGEIRHLTPERRAALRIADRAIPPEPAVEEPATTDRVYASGLDYDRAAVPALRGTPCVRCWTERTREDHRADGDDGLCGECRDRGRPGVPALPPGHTRADAVQARCAFLAATYNRPRALLAQWWRKYATVADRVVIADWVQRNPLPTDPGPAPRPRPVVPRVTGRCERCGDHADQELCVHCREVDDLTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF9</accession>
    <name>A0A7W7SZF9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="17556" checksum="FCA722BD47287293" modified="2021-06-02" version="1">MDEDPDADRLTALTRRLHDLHPAHDHATIESIAHAIDRDGHGGSGLVPDPLYWDPRYRDQPELWDWLESDYQVYDSADPRRLWRIPTTPDTPTVRAPRPRFRLEKRLRVRPAPYVGRAFVYAWYVGVSLAGRCVASEVWREYQDRGQPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZK5</accession>
    <name>A0A7W7SZK5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="31897" checksum="BC33F582DCD9F9A9" modified="2021-06-02" version="1">MDELVVEAMAVLDQALSRGRSSPEAWRDAVQAIGDRLLALQVTAASYADPYLNDVLDAQDTDPVADAVVQPAAFADTTDGGGSWLQGLVFAPNSVREPGVEWASRFAFVARSITATGITDVARGSVQAGMQARPATRWYVRMLTGKSCARCAILAGRQYRSSVAFKRHRRCDCRVVPAAESVRDWTVDPDEYFRSLTTEEQDERFGKANAEAIRLGADVAQVVNAESGVYVASAHGREYLATTTGTTRRGLAGQRLDGAARLLPDEIFLQAERLGWDREEILAQLRRNAYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL6</accession>
    <name>A0A7W7SZL6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">F4559_001251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6892" checksum="4BBEA01E4960AF06" modified="2021-06-02" version="1">MAAVCDVCGKGPGFGKSVSFSHRRTNRRWNPNIQTVRAKVSSSQRQRLNVCTSCLKAGKVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ1</accession>
    <name>A0A7W7SZZ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="44310" checksum="939BEEED3B06E77B" modified="2021-06-02" version="1">MTEAAVVRAHREEWARLVAVLTKRFGDLDVAEEAAAEAFATAVERWPVAGVPPNPGAWLTTTANRKAIDRLRRESRRDDKHGEALTVHDDDAPVGAIDDDRLRLVFTCCHPALAMDARVALTLRMVGGLTVPEVARAFLVAESAMGRRITRAKTKIKEARIPYRVPATEDLPARVSGVLAVLYLVFNEGYLATGPDTDPVRQDLTAEAIRLTRLIRELLPQDGEVTGLLASMLLTEARRPARVSATGELVTLAEQDRGAWNTDLIAEGHGLVRERLATGEPPGRYQLLAAINAVHTSARDIRDTDWSQILALYDHLARVDPSPIVALNRAVAVAELDGPEVALTIVDRLENTLSGYHAYHATRADLLRRLGRSGQSRAAYDRAIDLAGNTAETAHLTRRRDQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D7</accession>
    <name>A0A7W7T0D7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ORF">F4559_001046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="37958" checksum="9CD9D37227EAB9E9" modified="2021-06-02" version="1">MRVLAAMSGGVDSAVAAARAVAAGHDVTGVHLALSAKPGTLRTGARGCCTIEDARDARRAADVLGIPFYVWDFAERFTEDVVDDFVAEYAAGRTPNPCLRCNERIKFEALLDKAIGLGFDAVCTGHYARLSTVDGRIELRRSADDDKDQSYVLASLTREQLAHAMFPLGDSTKAAVRAEAAERGLQVAEKPDSHDICFIPDGDTRGFLTRKLGEQPGLLVDDETGAVLGRHVGVHEFTVGQRKGLGIDAPAPDGRPRYVLSLEPVTGTVRVGAAEKLAVTGIVATSPVTRVDLDGPVECVAQVRAHGGTAPAVARLVEGELRVELRAPLRGVAPGQAVAIYRPDPAGDLVLASATISTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B2</accession>
    <name>A0A7W7T1B2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="17699" checksum="C2A0C05BCBF03507" modified="2021-06-02" version="1">MTVTVRTEADLTRVLHDITTNPQPHPTVVYLRERPTIGRRNLPDHQLEFDIDVDYRIAAIHAAGVPDFVPHDARAQDDTETTQDMHGWVSRADASPDVGRTPTDGKGKPLYIDFGTRTEFPRNAMISLEQLRTALLELMTTALHPTCVDWQDSEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1C8</accession>
    <name>A0A7W7T1C8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21615" checksum="D0135F7233FF3DEE" modified="2021-06-02" version="1">MTTSGVTTRYLMRPGRAADRPQIANLVRARAAWMRDVGFGRWVGWDRNADELASQAGSGRWPTWVLCSGDRDVLGVTTAAVDTPDLGWGAEERAESAIFLQSTATDPRFARRGLGMIIAFWALDQAAREGRAWVRRGVLTIGRDNRGLVRYYRTQGWRIVRAVPHPRKHGVTVWSLQRPAERQPELGEFVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D6</accession>
    <name>A0A7W7T1D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10584" checksum="980435BE10C671C9" modified="2021-06-02" version="1">MDTGSVERVTVGTSVSRSEREGNERGEYLARALRVLEVVAAADEPMALSDVCRRLSLPMTTVHRLLGALCRTGVLRRDGRRRYSMGVRIAVVGDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T263</accession>
    <name>A0A7W7T263_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24905" checksum="B0258CFD710AD236" modified="2021-06-02" version="1">MPFESTAPFESTASTALTDLAATVTVPGIAAPGNWDHVARGFREWTDRPGLRERLRAHLGGLSSDDARRLVARSRETTTHFAWCLRDEPGEPFTFWLHEYKPRSDWRQGYADSVHNHRYHFCTVLLSGSYLHERFDARLGPDGGSILSTALLRRDEPREGATGTVLAHQFHRIPRACDGTMTFLVKSRAVTPWSLSYDPDTRLSHRHVPVESRLGVLTNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E6</accession>
    <name>A0A7W7T2E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyhydroxybutyrate depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031540936" evidence="3">
        <location>
            <begin position="25"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="30702" checksum="0263227C00E226F9" modified="2021-06-02" version="1">MASRHVAALVVAALVLGGCSTASGAEDVRTLTVDGRERTYRVHVPRGERLPVVLVLHGGGGDGAQVAAQTGMSAAADAAGYVAVYPDGTGRTSLLTWNAGRCCAYARDEGVDDVRFLSAVLDDVIARYPVDPARVFATGMSNGAMMAYRLGCELSDRIAAVAPVAGALNVDPCRPARPVSVLAVNGTADQSVPYAGGPPSRPVPGAGTWDNRSVADSIGFWTGHDACPAPTRQRDDDVEVTTWSGCADGSRVALYTVEGGTHAWPGGTRTRSGGDPVPPRPDTSRVVLDFFSGVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H4</accession>
    <name>A0A7W7T2H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="22489" checksum="D186929DE2BD5A63" modified="2021-06-02" version="1">MTTVGVVDDDPIFRDGVGTWLAAHTEDVVVVGVADSVAALRTLLVEPPDVVVLDVVLGGSLLVDNLAALEGWGPLVVVASEDGRSPEMRRRALAGGARTFVGKTAGYAPLRTAIDHVVATGWYTPPELARFLYSEPARAALSTRQAEALRLYAGNLALADIAKRMGISKDTVKTYLRQIRERYRDLGRAASTRAELGARAQEDGYDGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M5</accession>
    <name>A0A7W7T2M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="10764" checksum="947F7E91472A63B0" modified="2021-06-02" version="1">MATPIPMTDQPGPGPIRAGLRRCATAPDSSKAVADAGPRWPDADPRPGPGHRVPTSPAPAARPVLTFPAGGHRCGLYRLVCGFYECVHGHVRRIDAHIGAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N5</accession>
    <name>A0A7W7T2N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="6474" checksum="D9CFC8698D456868" modified="2021-06-02" version="1">MAQLDQLSATTTVVGIAEPHQSAVASILGAVALGVFGADEAELMIDRIRALATGNAADPLPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2S5</accession>
    <name>A0A7W7T2S5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA_binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="14767" checksum="7CBF23A86F05D14B" modified="2021-06-02" version="1">MGEAWGEVDTIRRVLALRGTWAVVGLSENPGRAAYGVAAFLRRHGVRIVPVHPDAPTVHGEQGYGSLADIPFPVDVVDVFRRSEAAGAVADEAVAIGAKAVWFQLGVVDEDAYARTTAAGLDMVMDRCPAIEWAANGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T7</accession>
    <name>A0A7W7T2T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="51"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="373"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="406"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="612" mass="66346" checksum="DE9E8C58276F89D0" modified="2021-06-02" version="1">MSTNTATSRPTQAPIGRGIMGMGMPMGKAENFKPSAKRLFGRLRPERTSLIAVVVLALISVSLGVVGPKILGHATDIIVTGMRSATGIDFTALGRMLGLALGLFALSGLFGWVQGRILNASVQRVVSTLRTDVEAKLHRLPLRYFDKQPRGELLSRVTNDIDNIAQTLQQTLSQLLLSFLTVVGVLAMMLTISPLLSLIALLLIPVSAIITGRIGKRAQGLFAAQWKHTGALNAHIEESFTGHQLVRVFGRRREAEAEFRTRNEALVESALGAQFVTGLIMPSMVFLSNLSYVVIAVVGGLRVTSGAMTLGEVQAFVQYSRQFTQPLTQVASMANVLQSGVASAERVFEVLDEAEQSADPADAESPTLRHGRVEFHDVAFAYDPDRPLIENLSLVADPGHTVAIVGPTGAGKTTLVNLVLRFYEADSGRITLDGVDITRMRRDDLRSRIGMVLQDTWLFGGTIRDNIAYGDPDATDEQIVAAAKATYVDRFVRTLPDGYDTVIDEEGSNVSAGEKQLITIARAFLANPSLLILDEATSSVDTRTESLVQHAMAALRSSRTSFVIAHRLSTIRDADLILVMESGRIVEQGTHDELIESHGAYHRLYSAQFATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T392</accession>
    <name>A0A7W7T392_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="47601" checksum="2FAB9E9CBBCC5C50" modified="2021-06-02" version="1">MAVRRTGLVRARQAAGFTQETFAEAMGVDRSAVVRWEGGTRRPSPHQRPRMSGLLAITTGALDDLLHPPPGDIASTPPSGGSGSLPIAMFHADAPSLQEEADRLGLATVGCADHLPDGGDDVLRRELLAGVLGVAGAALIGPSRADAQALSRVPATVNGLRRLVESVQSDYLACRYSRLAAGLPEVVRYAHALRASVDSASHARVDGLMATAYRHATWLALRLGEDGLAAGLSNQSLSIAQASGDPLVEAEAAQLGAVVLRRFDQTDQAQRLVLDTAGRLDSTGLVEPGHTAAYAMLLETGAYTAAIAGRRDTALDLHAEASLAVCTIGGAQPVTLTPSWIDSRHLGLYEISVHRKLGDFGTSIEAARAIRPGSITVTERLVRYWEDVALTFGAWGKREQAFHALLAAERAAPEEVRLRPWARDLTRRLRSSGPRLPGLTEFAARAAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C4</accession>
    <name>A0A7W7T3C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19258" checksum="408ED15F1511E7D8" modified="2021-06-02" version="1">MTGIPLPMPGGVDTLVAMTEVTVTLSVRDLTEADLPSCSWAGTRLHLTHVAAEVARARSGVGDYLAVCGPADVPLGIGGIDYRESPGAGTLWQLAVHPALRSCGIGTTLVRGAELRIRDRGLRRAELGVEDDNPRARALYERLGYVAYGREPDSWDEEGPNGDIRRYETMCTLLRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C9</accession>
    <name>A0A7W7T3C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="29505" checksum="9D4A60C9CD57B819" modified="2021-06-02" version="1">MLELSAAVAGLATGGAYALIGLSVLLTYRLVAVVDFAQASVGAFGAFSMVALLDADLALPLAVLAGLVVGALVHMGLGLVMVRWFAEAGEGVKAAVTIAVYLGLVAAGLRLFGTHPQAFPKPFDSPAATVGGVVVTWTAVVTMLLAVLFAVLPTVLLGRTRTGLLLRAMSERPTTAELIGIRVPRLSLVVWGVAGAASALGIMIVAPTLAGDFGSQSMLVTPALAAALVGAFRSFTWTFVGGVGLGVLQGVAGVVESLRQYRGVLPFVVILAVLVWTRRRDRWDTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3D5</accession>
    <name>A0A7W7T3D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17814" checksum="9E4DE2DC6D96D3A2" modified="2021-06-02" version="1">MGDAVDLVLAQWRAERPDVDASPLAVLGRVLRLARLLDRDLREFLAPFDLEPGEFDVLATLRRAGGHRGMTSGAFLDAALVTAGAITNRIDRMVAKGLVARVPDATDRRVVRITLTERGRTMVDGMLGDHLARYTRLLDPLDTRTRQVVADALRSLLQRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U7</accession>
    <name>A0A7W7T3U7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031344651" evidence="6">
        <location>
            <begin position="31"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="7">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="186"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="519" mass="55143" checksum="6DCAE505430082F9" modified="2021-06-02" version="1">MSRRNIAAKAAAVAVLVLGAVVVGFAPAYAASVTATFAKTSSWSSGYTAQYTIKNETSTAISSWKLEFDLPSGTTVGAYWDALLTSSSGHSTFTNRNYNGTIAPGAVVTFGFNATGTADPTGCKLNGASCSGTPTITTTTTTTTTPPTSTTMPTSSSTTTTTTTTTTSTTTTTTTSTNPNNPLPKRALVGYLHASFANGSGYIRMKDVSDDWDIINLSFAEPTSVTSGDLRFAQCPVAECPNVESEAEFVAAIKEKQAKGKKVLISIGGQNGQVQLTTTGARDAFVRSVGAIIDRYGLDGLDVDFEGHSLSLNANDTDFRNPTTPVIVNTIAALRALKAKYGSKFVLTMAPETFFVQVGYQFYAGNGGADPRAGAYLPVIHALRDDLTLLHVQHYNSGPIMGLDNQYHTMGGADFHVSMADMVLQGFPVRGDATKFFAGLRPDQVAIGLPASINAGNGFTSVADVHTAWDCITKASRCGSYKPKSTYPDLRGLMTWSINWDKYNNFEFSKNHRAYLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3X0</accession>
    <name>A0A7W7T3X0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="196"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="727" mass="80051" checksum="3B16E2659F233BCB" modified="2021-06-02" version="1">MSTHGYEQELRAERGYVDGLYGRLDDERARVRAAFDAALLGNGGTHLERDDEVRALGKVAKRLDAVDNGLCFGRLDPLDGKASYIGRIGLFDEDDDYEPVLLDWRAPASRPFYTATGAHPEGMRRRRQFHTRGRRIVDFTDEVLGRPGEDERGDAALLAAVNAPRGEGMRDIVATIQAEQDEIIRLDHPGVLVIEGGPGTGKTVVALHRVAYLLYTQRERMERHGVLVVGPNPAFLDHIGRVLPSLGESDVVFTTAGGLVPGLRVTAEDRPEAARLKGSLKILDVLRAAVADRQVLPAEPIRINLRDFTGRIDAAVAEWARDEARKSGLPHNEARAVFTEILTYVLTERAIARIGKGWLTRDNREAWERVRTELLGELAVDDVFTGALDALWPVLKPEEVLAELFSSPERLRSAGGDQALWRERGDAWTVSDVPLLDELVDLLGRDKADDRAARQEREAQAEYAESVLDSLISRADSMDDEDHLYAQDLLYAEDLADRFGETDTRTLVERAAADRDWTYRHVVVDEAQELSEMDWRVLMRRCPGKSFTVVGDLAQRRSPAGATSWDAVLKPYAEGRWVYRSLTVNYRTPAEIMAVAAAVLAEFAPEVRAPESVRACGVRPWSRGVTDDGLVAAVEEFVRDEAGREGTSVVIGPPDVPGAVPASETKGLEFDAVLVVDPDRILADGPRGAAELYVALTRATQRLGVLHRDALPRSLDGLVGRTAPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T440</accession>
    <name>A0A7W7T440_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22835" checksum="3F93F986DE006ECA" modified="2021-06-02" version="1">MPARLTHARVVDAAAQVADRGGLAHVTMRNVGRELGVEAMSLYHHVAGKDALLDSLTEWIFARIDLPDVDAPWRTAMADRATSVRTVLSGHTWALGLIESRRSPGPWLLRHHDAVLGCLRRNGFPVALAASAYSVLDAYVFGFVLTELNLPFEPGESAAEFVAQLDLPTDHYPHLAELVAEQITDPGYSYGAEFDRGLALVLDGLEARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T443</accession>
    <name>A0A7W7T443_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031603200" description="Peptidyl-prolyl cis-trans isomerase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23068" checksum="B41B754352BF4BD0" modified="2021-06-02" version="1">MRMVLVVLMIAFSVVAAPAAAATGTPGTKRCEFIPTPENPAAKPVRPPRPKASTKGKAVVALHTNYGRIVIRLDRANATCAVHNFVHLTRKSFYDRTQCFRLTDSPRLGVLQCGDLVRQEEGGPGYRFADEVTGKETYPRGTVAMGNQGPGTNGSEFFIVHSRADIPPVYSVLGQVVHGLDTLDRIVAAGIDDTDQDGPPKRPVRIHRAEVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A7</accession>
    <name>A0A7W7T4A7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA gyrase subunit A</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="9">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1127" mass="121142" checksum="1983376861670238" modified="2021-06-02" version="1">MARRKTPTTRVDPSAFDRAGAQVFDNSLTTEIEDSYLEYAYSVIHSRALPDARDGLKPVHRRILFSMNEQGHRPTSPYVKSSRVVGDCFVRGALVSTPLGLRPIEEIEVGDRVLDGTGREVDVVEVYENPASELVRVTWTNGRSMLVTPGQRFRTGPDEWTAARDLEGRETLRFGDERHAGLLADGGDARGYVLGLVAAAGVPDYGGLRLESADPDPVDAAHGWAIETGVGVDRDKVEGGDGRDRHILVFAEDPRRDGVHRTRADWAPYLAGLFDGAGTAHGDRITFADATDEVYAMLADSGIRTRIGDGIEVVGRDAAALAVALLRWSRSRIKQDALVRVIRRARGAGDADAVTVASVVEAEPDTTFDLQVGTAEHAFVVDGLVVHNCMGKYHPHGDTAIYDAMVRLAQDFSLNAPLVDGHGNFGSPDDGPAASRYTEARMSPAAMLLVGELDEETVDFRPNYDGSLQEPSVLPAAFPNLLVNGTSGIAVGMATNMIPHNLGEIVAAARHLVTHPDAPLDKLMEFVPGPDLPTGGVLLGLDEVRKAYETGRGVVRMRARVETGPLEGSRGRQAITLTELPYGVGPEKIIEKITDEVTKSKRLTGIADVKDLTDRENGTRVVIECKVGVNPQALLADLYRLTPMEQSFGINNLVLVDGQPRTLGLKALLEVFLQHRYEVVTRRTRYRRRKREDRLHLVEGLLRALLDIDKVIKLIRGSENAQAAKEGLMTRFRLSEIQAAYILDTPLRRLTRYDSLELEAEQDRLRAEIAELSLILDDEKVLKKVVSGELGKIAKDLTAERRTVLLDGDLKEVLAASKPAGPLEVADDPCQVVLSATGLVARTAAESEEASEARRRNGRAKHDAVAAIVHTTARGQVLLVTNRGRAVKTDVLPLPVLPEQGGTVSLSGGMAAGELLDLAKGEKVIGIAPLDPGGSPGLAVGTRQGVVKVCAPEWPVRSDEFEVITLKDGDEVVGATWLGSADETLVFVSSEASLLRYSAGLVRPQGLKGGGMAGINLGAGQRVVFFGAVRTDDDEHGEPLVVTSTGQSVKVTPFSAYPAKGRATGGVRAHRFLKGEAELLLAWVGPRPAGSSDTGAAVELPAVDERRDGSGHAHPGPDVVGHLVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4D6</accession>
    <name>A0A7W7T4D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030804268" evidence="2">
        <location>
            <begin position="18"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114027" checksum="3E97412A69791718" modified="2021-06-02" version="1">MVAALVLVGVTPARAQAADRAFTAVSPAPDFVLPSIVVQYDPARSTGIDWRTTTSIPVTEYQTDRSKARDAVVFVQEAVTKMTGRTLTVKNSADLSRGIVFTTIAGATPDIRDDPAVIQALAGGGPDAKEAYYLRSTPERLLLVANTYDGLASAAAKLMETVGYEVLGMGPNWVFAPTAPTLVFDVEQSGRPGFHTRQLTAMSGQYYGVGTIVNAPLADPADENVERGYRRWQTGALMRGQSAPSFPGHSLQAYHKAVAQDIRDSGNPAGFLAPTHLGTDAARQALPPADAKDHLWITSDGPLQAYVSNGTAWVLQTLGSGSLALDLSVRTVRERVLREVRTWAENVHFKSRPDDPAILAIEREDGGRPDAVFNANTRDRAWYPEYLSAEGVPFGAPWALHGFKGLNQPREIWDSASQSDTVYGFANWLLREYDKWLDAQPPGDRVTSTGKSKKSLLRASFYSYNYHDVPPHFNLDPRIRVAIAGYTKHRGVGEWRSIVTHLDIGQAMARLLPAEPPADYRIYSVAHATDWGMANLPARHDLSAAAIADDISAYHRGGFRTFLAETDLNFGKFGLGYYLMAKMLWNPTLTAAQLDAVRTRWLQRAFGRGWAKVKEFVDFMLLPNFPVNTPYSWGRAVELVDAADRLVDPVAEPGPDRRLDDLKQFFYYYFLQDSGRMTTDAPETREFMWKGQMSYMNALMVPLSKVYGRTDPAAVAGPQTAAGPAHYTAAETAAWWNQVKAYWPVRAVNRFEDATLADGTPAAWVDRNDVGPAAEFVTPGAPAARFLYNSATSGHTPRFLTSAEPGVHIGFQLLWQKYDNGTTQYASRDVRYGIERWSATTKSWISLRDMAQPGVTPTELASCPQFVNRVCLLATVSIPASSHDVHRFTVGSGGDYAYLYPLTFNVATNQSTGRSAHTYTGPGAGLTQAPSYFYIPKGTTSLDLEVWDRYGGKTLRLYSGLLSKNPQAAFRDVDISAYGTNSVPLRPEEGGTIARISASGFAFPYLHSVPRLWAMSPNELVVPCAIAKADGLTVPPGRCDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G0</accession>
    <name>A0A7W7T4G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NitT/TauT family transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="90"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="29981" checksum="5DA632C3CEC191D2" modified="2021-06-02" version="1">MSTVVLEKPEAPAAVPPRPVDRSAFHALPGLLAKVVRKTVAVVVLLVVWEVAPRLGLVDATFLPPFSEVAVAWWELLLNGQLASNTEASLVRSLSGFGLAVGTAVPLGLLIGWYRPLADLLTPLLELFRNTAALALLPVFVLLLGIGETSKIAIVFYACAWPVLLNTISAVRDVDPTLLRLARSLNLPPHRLFQKVILPASVPTVFTGIRLAGAVSILVLVAAEMVGAKAGLGFLVNSAQFNFAVPQMYAGIVTISVIGLLFNLLLVSLERRFTSWKGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X8</accession>
    <name>A0A7W7T4X8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SagB-type dehydrogenase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="265"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="463" mass="50594" checksum="938ED04750F46B77" modified="2021-06-02" version="1">MTDIAVAADVGELLSLRPGVYSAIGRDGGVALLAWPNADRLGELDEDLHAVLRALAAGPTGTGALRALADPERVDALLDRLRHGGWLAVTVVWRDRPLYTLVPLTTPPPMPGHVPADPVLSRFAVLHRVDGETVAESPRAWCDTRVHDADVLALLAGLPAGGLPERVVRDLHWAGVLVPDTGAEDEEFALRQWSPHELWFHDRSRLGRRGYLGDRFGGTFWARDRFPAPPAVPEPFAGPVVPLAVPDLPARRREDPTLTAVLEDRETVREQDDAHPLTLDGLGEFLYRCARTRLTRVGDDGQEYASRPYPSGGSVYELELYPLVRLVDGLEPGLYHYDSHGHRLEFVRADADPAVRRMSRVAALSTVAERPPQVLVGVSARIGRLMWKYEAMPYSLALKHVGVLYQTMYCVATAMGLAPCALGGGDSRAFAEATGRDPLVECAVGEFALGSRVRQVPVWELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T505</accession>
    <name>A0A7W7T505_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7541" checksum="A229AC113A5D71A6" modified="2021-06-02" version="1">MNSASAIDMNTWIKIGKESYPEFTVSGADIEVSFSGRQLDLVFSESALRAFVAKAAEALDGIDRAGSLSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T517</accession>
    <name>A0A7W7T517_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="666" mass="68518" checksum="4B214A4EF536ED0C" modified="2021-06-02" version="1">MPAPAAPVHAGNPPAVGSAAPEVPAADVPAAPPTAETPTAASPGEWSSVPPAAAAEAPAPESPTARVPGAEVPTAEPPAARASDTGPAAADPLGGRAPASEPPAGGTSETSETTVLSAGSWRPPVEVPPGAAHTGAPSPAAPSLAASASTASSPVEASRTEVLSGAAVPTAAASPWAQDGPRGFVEGETTTLSGGTAGFAGPPPGQAPPPVVERVVDPPAAALGNASFLGVGYLQLGRSRLAVLTGLVTVVLLVVLAAFVRSVWLEVVVVLWWLALIAHGWRLAGGRARTPGPDARRQRLGALAAALPVLLVIGFLRLDAAVIEGDAEDALAAGDCGQAVTAVDRLWFGHRVVDAPLTGRGDDTVRTCRRLDSAAASLTKGLEGDTISIKNGFDDLTAVLAEKPDYGNVVNRVLDDFLGKLPTPDACDTRDITAWLRERGTKGNALDRAAEVAPRVAPPAILACADGLMTSRQFEQARARYQELVDVYPDHELAPKAKEGVQKATWEIELANVRQLLNTPSQDRPRYCDAPAQYSAAPAYGAQRPNRAWVAGKNEHTRRLPGDWLVDDVANATVVVCVGSVAHGSVKETCDYVPVDGSGGSTPVAFHRIAMPVRVYELKTGKLVSDTTVEINGASCPERLSYRTGDEYVAAADSDVHAAFSPFINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T519</accession>
    <name>A0A7W7T519_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="22961" checksum="06442F29F2980C44" modified="2021-06-02" version="1">MRVVIAEDDVLLREGLSLLLGTAGIDVVAAVDNATEFLAVIADDRPDAVVMDVRLPPSFRDEGLRAAVEARRVHPGLPVLVLSAYVEDSYASELLADGVGGVGYLLKERVGKVGEFLDALRRVADGGTAMDPEVISQLLVRRKVDDPLSTLTAREREVLALMAEGHDNGTIAGLLVVSEGAVHKHIRNIFTKLDLPNDEGGHRRVLAVLAYLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T525</accession>
    <name>A0A7W7T525_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA(Arg) A34 adenosine deaminase TadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17285" checksum="58C25D0E48AE7BB2" modified="2021-06-02" version="1">MDDMDKWVKEAVALAERNVARGGGPFAALIIRDDDLLATGTNQVTATLDPTAHAEVVAIRAACQAVDDFRLTGCTLISSCEPCPLCLSAALWARVDEVLYAADRNDAAEAGFDDRAFHTLFTRPRETWPLSVRRHPTTDDKAPFQAWLHKENRIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T577</accession>
    <name>A0A7W7T577_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Regulator of SigK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sigma-K anti-sigma factor RskA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018764">
        <property type="entry name" value="Anti-sigma_K_RskA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10099">
        <property type="entry name" value="RskA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="27482" checksum="56173ECC51BF4422" modified="2021-06-02" version="1">MTGERRDAWCPQEELAVGWAMHTLEPDEEAFFSAHLSGCALCARTVRSTQEVTAVIGGSVPQYDPPPRLRGRLMEAIGHTPQQHVVAAPVPEVVVALRPRQPKTRRNVLVAAAAVVLVAAVGIVGVRFGQMSDQLADQDRLRSALEVAVAPGTDRAVLRAESGEPIAVLLSGDREAAVMPMDLKSNDVATQTYVVWGTSAPIPVPLATFDVGSTRDVRLLTWSPDAHKHRGFAISLEPGRAAPSAPTDVVAKGAVDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P1</accession>
    <name>A0A7W7T5P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="44794" checksum="638B701D88DF5C21" modified="2021-06-02" version="1">MPERNEQLRIARERVESPSCPGEPLTRLELADLVNAHVYRATGKVTAVDANHVGKWERGAFRWPAAYYRNALRTVLDVGTDAELGFRRPARGKPDDVDRRALLKTALGASAGVVATRRLPGPAVDLDDLATAIMGPTAHYRRMESAVPSDQLAPAVDAHLRLASGIVASRMRNSTGYGVLSEIAGLSAWLAVDRDDHAAARKRYTEAVAHAERAHHPLLAAYMTASLGHFAVEAGHARQGVVLLDRAANQLDKSAPDSARAWLASLHAVGHAALGDRTATLIALRVAERLTSRKGGEPRWPWVFTFDRAKAARYQASALGRLGDLRAARDAFAGADPALSAAKPRALAQVDLAQVLAGAGMVDEGCRLALAALAVGRDYGSERITGRVRDFRQALPVRTRDAASLDDALTALYEGETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P3</accession>
    <name>A0A7W7T5P3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N,N-dimethylformamidase</fullName>
            <ecNumber evidence="1">3.5.1.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.56" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050116">
        <property type="term" value="F:N,N-dimethylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="849" mass="91953" checksum="0F056F31E42C0D88" modified="2021-06-02" version="1">MDSSVVAIRARFAERRAEQLRPLLSDDLVDTWLRDPGATHREPISWLARFLDARPAVERVCVHESGGTWRLARPPAHRGETYRLADSRVFTDADEAREACLRRQLFDVFGWGEPPAHAVDGPELRHEDPVLLGYADRVSASPGETITFMVSAEGVAEYTTGLLRLRHVNDDPNGPGVRVETVPDLWTGTHRGHAQRTVPGAHVAVRDPHGATTGEGGFAIAAYIHPTVTGREQAVIARWNDGDRGYALGLDETGRLEFRLGDGTASTVVHTEEPLVPHRWHGVAASYDPATGRATLVTRPLVTSANSRVSPIVVGDAPIVVERRVDAAFTPADHGDLLFGSRTPESGHYNGKIERPGLWPHPLSRAALIAVVSDDHDAPLRWDFEPGATAAGLVVPCVGRPGLDGRLVNLPVRGVTGRHFTGRVEHYAVDPRGYAAIHFHDDAVTDADWTPSHEFTVPDVPAGVYALQVTATDGSCDRAVPFVVRPPAGTATGDLALLLPTATYLAYSNERGLGYVPVVPDGTVFLEQRYDLGHSAYARHTDGSGVCYTSWRRPILTLAPGFRVHLSPFMLEADLYILDWLTELGYSFDVITDHDLHAEGVDLLRRYKGVLTGSHPEYASEQMIDALESYVDGGGNLAYLGGNGYYWVVSFHPELPHVMELRRGELGTRSWQAKPGEYHHATTGERGGLWAGRNRAPQKVFGVGFSAQGGGPSGYYRIGPDHDPVLDDVPEVFGNQSLDHGGGAAGNEIDRYDPALGSPPDALVLATSEGLGDDYQFAVEEVTGTNPGKGATEHPDVRSDIVYFRTRGGGSVYATGSISFSSGLSANGYDNGLSRLTRNVLDSWVADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U1</accession>
    <name>A0A7W7T5U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2087" evidence="2">
        <location>
            <begin position="90"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="18314" checksum="34B3B3428528846D" modified="2021-06-02" version="1">MTPDSLVGLLADTSRLRVVAALALGSRTVGQVVDATGLDDRSTANALRRLESAGLVTRADGALRLRAELFAEAVRTDRTNRDPFVNGQKLIALPARRERRREVLEQVCASFEPGRRYPERDVDAVLREWCDGGGIDHVTVRRYLVDEGLLSRADGQYWRSGGPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T616</accession>
    <name>A0A7W7T616_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="77"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="40344" checksum="5BA1F70B810518A6" modified="2021-06-02" version="1">MSVQVKYVDAGDLYVTWRWEHLRDQPRAVLVERAHVREASAALDAAVPSPNRNESGHDAVRRALTGPLLDLGAERRLAAALSGALLPAQLCAELNSLLSQQIRPHLRIQPSPSTARVPWEALAVSDAERLVHLADTSVLLPATVRNAPERRVSTGDGPVVRVVDPVVPGFADASALGSVLGPGAPRPVVDRDSLEELLVTASRFLYVGHVTTGGHALDARLHLSCGPDSEGRAGLVGGHRPLTAADLVLGHRAGPRRPWRIPRRVALVACESGGDLRFAEPSGLVAALVHGGAEHVVATRWTLPTDAGLAALVPVFPGTPVLRPAVRAIDAAQQADDPVAALNAWQRERADEWERTGDPACSPVVWAAFGTAWAPQSTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A0</accession>
    <name>A0A7W7T6A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.28" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04316">
        <property type="entry name" value="dhbA_paeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="26295" checksum="F3C36916DBDB23F3" modified="2021-06-02" version="1">MSGKIALVTGAAGGIGTAVVRALTAEGQAVAALDADAEALALLVKTLVADGGTVRGYPVDVSSAAAVTDVVTRVEDELGPIDGLVNAAGVLRIAEALDLRDEDWDITFAVNTTGVFNVSRAVARRMVTRAHGAIVTVASNAASTPRWNMAAYAASKAASSSFTKCLGLELAGYGIRCNVVAPGSTDTPMLTSLWSEAADAALRASIDGIPGQYRVGIPLGRLARPEQVADAVLFLLSDRASHITLHELTVDGGAALGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P5</accession>
    <name>A0A7W7T6P5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33124" checksum="3977DA2070CF67F7" modified="2021-06-02" version="1">MRVVVVGAGIAGVACARALADSGVVVRVLERGRVVGGRMATRRYDGRRADIGAGYFTVSDARFAAVVARWRDAGLAREWTDTLTVHSPSGWSTTAEPMRWAAPGGLRSLVVDLARGLDVRVESEVEWVEPGPRVDGARTDAVVLAMPGPQALRVLDPRSRAVRAAAEGQGWQPSLVATLRFPKRTWDFPGVFVNGNPVLRAIFDDGSRRGDNAPVLVAHTVAAFAEGFVADPTDAADDIEAAVRELIDLPPATSRAVHRWTYAIPGTPNPAPFFFGEEMIGIAGDAWGLPRVETAWLSGTLLAEALLTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T760</accession>
    <name>A0A7W7T760_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="566" mass="60885" checksum="B310BC9A80C395DB" modified="2021-06-02" version="1">MIAEASAAAGAATGSELSYAELDRSARTVAAWLSEQCVPGDRVLLLSPLGPEIVKNFFGCLYAGVVPVVAPVPTGRDHHLARATGIAFDSGARVVLTDVGSLSPVHEWLSQDGMEELVCVATDVVELGDPGDPVDVVRGPADAAVLCYGSAVGELVATEIGYAALEQGLARTRAAFGVTADDRLLSWLPPDNYTGLMNVLTALSAGATAVLMPTRDLARDPVRWLELVDRHRVTISGGAATAFARCARAVEERLPTGLDLSCWRIAYTPSTLLDPAVLGRFADAVAPLGFDPAALRTTYCLPEATFLVSSSTPGRAPVGTRVSATALEERTLVESERPEDPVLVGAGRVERLDVRVVDPESGRELPDRRVGEVWVRGSGLARGYWGHEVESRRSFDARLDDGQDGFVRTGDLGVLDAGELYVLGRADGMLTVSGRTLRAHDVEREVAERFPGLGAHRASVFTVPVGREEVVVVQEVEHHDLDELRSLAAALRSWLRRRTRVRFGSVVFLGPGMPAIGCDRARRALMRDLFVARAAEPVYEELDADVRRRYRPPLGTARRSHVRIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A4</accession>
    <name>A0A7W7T7A4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="42" mass="4366" checksum="E534FD8E47B62CAA" modified="2021-06-02" version="1">MTPARRLTVALIGLLLLVVIGYTIRTLTAAEPAPPTTTTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V0</accession>
    <name>A0A7W7T7V0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ORF">F4559_005562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25479" checksum="FA9E98049C1DFE0F" modified="2021-06-02" version="1">MIRLEHVSKVYKSSARPALDNVSVELGKGEFVFLIGPSGSGKSTFLRLLLREEVPTKGRVYVSNFDVAKMSRRRVPRLRQSIGCVFQDFRLLTAKTVAENVAFALEVIGKPRNTIVKVVPEVLQLVGLDGKADRMPHELSGGEQQRVAIARAFVNRPLVLLADEPTGNLDPDTSQDIMLLLERINRTGTTVLMATHDHSIVDSMRRRVVELDHGRIIRDDARGVYGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T805</accession>
    <name>A0A7W7T805_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045926">
        <property type="entry name" value="DUF6345"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19872">
        <property type="entry name" value="DUF6345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030871474" evidence="2">
        <location>
            <begin position="31"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="532" mass="56435" checksum="5E37DCB684B8321E" modified="2021-06-02" version="1">MSTSRRAGTWLAVTGLLGATVIGGAPGAAAAAELPVYAVRSTGLTADQATALQRAFGLKSVHRAEDGSVSFADEATYLRVPGLDAGTGQADEEGQATTGTKLDLDAIKRLRAIGEADAIKKAAETLRGVGLLPAGATPTARQTTLEVVDADGKAVVSAPLDTAVSFALSVDGVPLEGAGAKIRIAFDGSGAVSALTYSTRELVKVGSVPVLDQAGARERCLKVLGADTRLSGVSYVYDSPALDEKVDRLEPSVRCLAEVADTPSAQAVTVPANPSASLPQPDPTPPPREASFGTASIPRVDVGDEGTGWCAGLPLTNLNNNRFDAEFTGRGIPVQFKWRDTNAWERDFKDPAFPYGWDQLYVDDVDLTYWTGRGSPTGLSFAGCSAQSDSFLANTEARWGNRDLEWLSLYAPGVLRSTWAGKSWAARWGKAFQGLHQINGFDSGVVHTSTHGRKFGNYLLRTPFLWWNKPLKVRAAWAQASIDTQPSSVVWSTMGPIGSSWIANFDDYFWGKGPVGPDTLPTVGWWRISGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T808</accession>
    <name>A0A7W7T808_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="646" mass="66881" checksum="FEB37F49655D6E97" modified="2021-06-02" version="1">MRVLSIDLGTSNTVAVLAAHGRPPRVVEVDGSATMPSAVYCEEDGTLVVGRDAERRARLDPSRFEPNPKRRVDEGALLLGDNVVPVTDALAAVLRRVLDETTRQLGAAALDEIRLTHPAEWGATRRNVLLSAARLAGLTGELVLVPEPVAAASHYASLAVGQALAVYDLGAGTLDVAIVGATQNGFAVLADDGLPDLGGLDVDQALLEHVGRQVSHRDPAAWQRLLRPDSTADRRARRALQEDVRAAKESLSRHPHTEVPMPEPFEDVLVSRSDLEALIKPSLLRSVELLAATIRSTGIAPEHLAGIYLVGGSSRIPLVASMIAGHLRVVPTSRDQPETAVALGAHHVPKDGIGPRPPKPASAEPATVVTTSVTPVVGGPRPVGPAVGGPHPTTPAAGLPHPANPAASGPYPVNPAVSGAHPVNPAMSGPYPVNPNTSGAYGIDQQVFNFPSVGDRQTKPRGKSPRKAWIALGAAVAVVLAVVGGIYAFAGQGIPDAQECKTDLAKDAQGFTHCLRQLAGAVPDTATCKPGAVEGAGLDAIKGTVISCSLRDDYTVQYVLTDTVTGAEQGADAVVRSLKSDIVQADWAGNGLAGRYRSAAGDGVGLLVFTSAGLPVFGIVTKSSGGDDLTADGMADYFERTVQPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T846</accession>
    <name>A0A7W7T846_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="Extracellular_endonuc_su_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="PTHR13966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease_NS" evidence="2">
        <location>
            <begin position="374"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="NUC" evidence="1">
        <location>
            <begin position="375"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="604" mass="65457" checksum="DF1B606E208A8E1D" modified="2021-06-02" version="1">MAKKTGQLSAALREFVRTRGGDYLDDPNVSSIGVGHKIEGGRPTDRVAIQFTVRRKAEPERLEALGTALLPATIQVGGVEVPTDVVQRDYRTQFRVVEAADKPERKSRVDPVVPGVSVGVPGGSAGTVGLVVYDRDDGTPYVLSNWHVLHGTSGRIGQDVVQPGPHDDNRVERNRLGVLARSHLGAAGDCAIATVEDRAAGTEILGLGVTVDEIGEPELGDKVVKSGRTSGVTHGIVRRVDVVVKIDYRGDVGEQRIGCFEIAPDPARPGPGGEISQGGDSGSAWVFKSANGRTSRVLAGLHFAGEAGDDPDEHALACLPSSVFEKLDVAVKPPAVVEAVGTGFDPDFLGVAAGLPELGEDSDAVEVSGRTVVDYTHFSLALHGTRRFAIYVAWNVDGAALLNLPRTGIPFVLDRRIPAKFQVGDELYRDNRLDRGHLARRADLVWGPKKEAEKANRDSFFFTNITPQMDDFNQSARKGLWGRLEDAVLDGAEADRLRLSVYGGPVFADDDRVFRGVKLPREYWKVIVFVREGALVARAFVLSQNLDRLESLDLDEFRVFQVALGEIERRCGFAFPAPVRDADTFVVPESEVRPPLESLDDIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8F5</accession>
    <name>A0A7W7T8F5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="7">1.13.11.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009072">
        <property type="term" value="P:aromatic amino acid family metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="PTHR11959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="6">
        <location>
            <begin position="194"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="44004" checksum="073626B7E36E917D" modified="2021-06-02" version="1">MTQQLDDVSYDQLRQLVGLVDYDGSKDPFPVRAMDAVVFVVGNATQTAWFYQVAFGMELVAYRGPETGHRDHKSFVLKSGSARFVINGGVAPDSPLLDHHRRHGDGVVDLALEVADVDKCVEHARAQGATVLDEPYDVSDEHGTVRVAAIATYGETRHTLIDRSKYDGPYLPGYEVRTSTVVRPEGAPKRLFQAVDHCVGNVELGKMDYWVEWYNRVMGFVNMAEFIGDDIATDYSALMSKVVSNGNHRVKFPLNEPAVAKRKSQIDEYLEFYEGAGVQHIALATNDIVATLSAMRAAGVEFLETPDSYYDDPELRARIGEVRVPIEVLKEHKILVDRDEDGYLLQIFTKPIGDRPTVFYELIERHGSLGFGKGNFKALFEAIEREQERRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J4</accession>
    <name>A0A7W7T8J4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23892" checksum="4ED0F88D4BF63891" modified="2021-06-02" version="1">MAGRRRDDGAPVPRVRMTGKERREQLLDVARALFAEKGFEVTSVEEIAHRAGVSKPVVYEHFGGKEGIYAVVVDREMQYLMDHIVNALSGGHPRELLEQAACALLDYIEGSTDGFRILVRDSPVASSTGTFSSLLNDIASQVESILGLHFSRQGYDRKLAALYSQALVGMVALTGQWWLEVRRPKKDEVAAHLVNLAWKGLSHMDHKPKLRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M7</accession>
    <name>A0A7W7T8M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22044" checksum="D058AAFCBF8E71C3" modified="2021-06-02" version="1">MPELVLADPAERDDLGAFVARAVRLEAGAVVRLRNRESGGLLDAWVATPFDTLATRTVAGRVEPGDVTVSGSDLLTGLAVVRSEKVDPGPARDLLWRSALPPTQGWLPVDRLPGDVVAELAEQGVAVARENTGPHGTPPASLLDQTVLTVSGSGLDVKVPLRCLFALSGMGFLAGDDVRVTATDSWLRIDARYGAVVRRRHSMLPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z0</accession>
    <name>A0A7W7T8Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="22440" checksum="A8027B560404BCF9" modified="2021-06-02" version="1">MGDLRMTGERPPWEGLDGTDRHAACVVAARAGDRRALNVLVNDLTPLVWHVARGHGLDRSTAEDVVQTVWLALLRHLDRLNEPRALAGWLVVATRRESQRTWTPARREAQLSDELADNLESDFGLPEDAALIDDRDHRLWRAFGRLSQKCQELLRLTVLAGRAEYRAVAEALSMPRGSIGPTRGRCLTTLRTHLDAEGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T947</accession>
    <name>A0A7W7T947_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-hydroxyarylamine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.118</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.118" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046990">
        <property type="term" value="F:N-hydroxyarylamine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26461" checksum="5C142DE44B7C8E75" modified="2021-06-02" version="1">MDTRTAEAYLARIGARRDSPLRELHERHVRSVPFENLDIHLGRVITLDEDALVDKIVHRRRGGFCYELNGAFALLLRALGHDVELLAGKVFADGVFGPPFGHLALRVDGLLVDVGFGRFPLPVMAPGGRVDGVEVVDVDGDLDVRLDGVTQFRLETRPRSLDEFGATSWYHQTWPGSYFRRNPLCSLPTADGRVTVAGSKLIVTVGEDRHVEDLDDAGIIAAHAEHFGVVLDRVPGLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T979</accession>
    <name>A0A7W7T979_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecB family exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30780" checksum="01ECD5EC96D80E20" modified="2021-06-02" version="1">MPEQLGFDFGAMPKKLVRVTPAKLATWADCPRRFRMAYLDRPAPPRGGAWAHNTLGAVVHNALKGLFDLPAAQRDPDRAVSLLHRQWKSEGFRDADQAAEYRERAVGWVHDYVAGIDTSIEPVGIERWVSTPTAKIVAEGRVDRIDLRDGELVIVDYKTGRHALSADDARGSQALALYALAARRTLRKPCRRVELHHLPSGTVAVWEHTEESLGRHLGRAEEAADELGLASDTLAAGGDPEILFPPRTGNQCTWCDFRRSCPEGRAASPELEPWASLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I3</accession>
    <name>A0A7W7T9I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009467">
        <property type="entry name" value="Glycolipid-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06475">
        <property type="entry name" value="Glycolipid_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21753" checksum="A3787FC85397B133" modified="2021-06-02" version="1">MDTSSDAGARPPGARILTWQGYDVPRLEQVRFLLSERKLRASGRLVTAGDRHFSASFEVSVGDTGAVTRLLLRTATATEERQLSVSRSSEGQWLIDHGGGAERADFDGALDVDVRSAVLFTAIPVRRLNLHREEGGHELPVVRVTLPDLSVELVRQRYRTVSVGDDRSVVAFTDDGVEQLVTVDDAGLVLDRPGVAHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA11</accession>
    <name>A0A7W7TA11_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9630" checksum="225110C711C3D014" modified="2021-06-02" version="1">MTAWGLSTEGGTRARDLAVLSDQQRVVLRCLARGLADHEIARVLALSQRQVASVVADILRALGLRDRMAAVVFAHETGMIRLPVPNGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAI0</accession>
    <name>A0A7W7TAI0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26593" checksum="9D2A4343F09EB818" modified="2021-06-02" version="1">MPGGWTTQRWTDAFTAQAALFRAAVGEANPQDRVPSCPGWTFVELVLHVGRFLETSLEYLRTGGTVRLRLPAPPEHVAPLAYLDEQLAKAAEILPVVPGNRTAWTFSPAAPDLAWVWHRRIAHEVDLRRWDAQAALRKLVVGDADFAVDGIDESLTTLLAAKYDTDVPLSVSGKALIRLTDVPESWVVTLTPGQVPDVRAAWPGEEADAEVVGEAQLVHYGLWGRLPLKASGDPDVLRALRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAL2</accession>
    <name>A0A7W7TAL2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polar amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27256" checksum="0387F0BEDB36D606" modified="2021-06-02" version="1">MNPVLGVRGLVKRYGDRTALDGIDLDVHEHEVVVLIGPSGSGKSTLLRCVDLLEEIDDGQVLLDGVDVSDPRVDPDVARRGIGVVFQSFNLFPHMTVLDNVTLAPRHVHGVARETAESRARDLLDRVGLADRADAYPDRLSGGQQQRVAIARSLAYDPRLLLLDEITSALDPELVGEVLALVRELAEQGRTILMATHEMGFARRVADRVCFLDGGRLIEQGPPEQVLGDPEHERTRRFLARIVDAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB16</accession>
    <name>A0A7W7TB16_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23699" checksum="CAA5A70BFAFF3D0F" modified="2021-06-02" version="1">MRVVLGEDLVLLRDGLIRLLQAHDCEVVEAVDTGPDLLRAMVDHRPDVAVVDVRLPPTFTDEGLRAAIEARKRVPGLPVLVLSQYVEHLYARELLSDRAGGVGYLLKDRVSDVRQFVDAIRRVAAGGTAMDPEVIDQLLARSGRDRPLATLTPREREVLSLMAEGRSNAAIAGRLFVTEKAIGKHIANIFGKLDLPLSEDDNRRVLAVLAYLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTS0</accession>
    <name>A0A7W7WTS0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="40356" checksum="76E81214734F6A33" modified="2021-06-02" version="1">MSARTTLLAFGAFTVGTSGYIVAGVLPAVSAELHVSHATAGQLLTAFAIAYAVSSPVLAALTGRWERRTLLVAALLVSALGNAFAAIAPNYPLLLVARVISAFGAAVFTPGATLVATVLSPPERRGRAVALVFGGLTAALIVGVPAGNLLGGTLGYRGVFALIAVVSVLAAVAVRQWLPRVDAPPVVGLRARFAPAADRRVLGVLGVTVLVCVAVFSVFNFIAPLLHATAGLDGAVVGGVLVAYGLGAAFGNWGAGVLADRVDTRRLLVTLLSLFVVVLATLPLTMTSVFTSAVVLFVWGALTWSANPPIQSWLIRLAPADAGLLLSLNASAIYLGVGLSGVVGGVVISWVGLGPLAPIAAVLGVVALGLLLVALKPAQEPNALVVTSPASGSLARQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU18</accession>
    <name>A0A7W7WU18_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21154" checksum="4D1D16F3934129CA" modified="2021-06-02" version="1">MTSHPDTSSGPQYPTPWRCGESHGTTAIVAADGRVAAQAVPDVAKMIVRLVNAAAACGGISTTRTGDSRYRTGSHNPRNVYTDTGDRDTDEHVAVALDPAFGPVIAAALNRAACGGGAVSGGHYGVDELRSATSAWARERESRMDWAAEAMRVDAAIAGLAADFRRMASLPEAGECVRGMCELVVSHLDAIRVQPDEEDGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU20</accession>
    <name>A0A7W7WU20_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase / fumarate reductase membrane anchor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000407</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15502" checksum="B56B1131E7839BC0" modified="2021-06-02" version="1">MSLTLDKPRSPRRPAARRSNLELYSWLFMRISGVALLVLVLGHLFIMNILDGGVHRINFGFVAGRWASPFWQFWDLSMLWLAQIHGGNGLRTVINDYARKDATRFWLKVLLYVSMVLIIALGSYVIFTFDPDITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC9</accession>
    <name>A0A7W7WUC9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aerobic C4-dicarboxylate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="44154" checksum="F7DCC18A242203B3" modified="2021-06-02" version="1">MATEEHRRTPLYRHLYFWVLVSITAGIAVGFLFPDRAAGLKWLADLFVALVKVVIAPTIFCTVVVGIAGLGNLARAGGLALRTLAYFTAMTTFALVIGLVVVNVVRPGHHGADVPLVDDVADQTLAAAKTAETGVTGFVLGLVPKSFVGAFTDGQLIQVLVVAVLVAIAVAGLGTRGARVVEALDTVAQVLFGVIRVVMYVAPIGAFGGIAYTVGEFGGAVLGKLAWLMASFYATCVLFVVVVLGGVALVTGFSIFRFLRYIRDELLVVLGTSSSESVLPRMLAKLEAAGADRSVVGLTIPTGYSFNLDGTCIYLTMGALFIAQATGHDIGIGTQVGLLLFMLLASKGAAGVTGAGLVTLAASLTAFEAHSAIPAVGIALIVGIDRFMSEARAITNVIGNGVGTLAIAAWQGRLDRTRLRAALHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD1</accession>
    <name>A0A7W7WUD1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="15" type="ORF">F4559_001473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="13">
        <location>
            <begin position="24"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="692"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="607"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115776" checksum="C12B28E89B8963C9" modified="2021-06-02" version="1">MAYPKAGGDSVPSQPSFPELEERVLDFWKSDRTFQASIDARPVGDAGANEFVFYDGPPFANGLPHYGHLLTGYVKDVVPRFQTMRGKHVERRFGWDTHGLPAEVEAEKQLGFSSKSEIESFGIEKFNDVCRTSVLRYTGEWRDYVTRQARWVDFDNDYKTLDLDYMESVMWAFKTLWNKGLVYEGFRVLWYCWRCETPLSNTETKMDDTYRDRQDPAVTVGLRLETGELALVWTTTPWTLPSNLAAAVHPDVDYVAVEANGERYLLAEARVAAYARELGEEPPVVARYKGTDLVGRRYAPPFGFFVGRENAHQVLPADYVTTEDGTGIVHIAPAFGEEDKLVTDAAGIEVVIPVDPHGRFTAEAPPYEGQHVFDANKAIIRDLREAGLLLRHETYDHPYPHCWRCDNPLIQRAVSSWFVAVSRFKDRMVELNQQIDWVPSHIRDGQFGKWLENARDWNISRNRFWGSPIPVWVSDDPEYPRVDVYGSLDELARDFGVRPTDLHRPGIDELTRPNPDDPTGRSTMRRVPEVLDCWFESGSMSFAQVHYPFENADWFESHYPGDFIVEYNNQTRGWFYTMHVLATALFDRPAFRNCVAHGIVLGDDGQKMSKSRRNYPDVNEVFARDGSDAMRWFLMASPILRGGDLVVTERGIRDAVRQAVLPLWNSWYFLALYANADGVEGRWRTDSTHVLDRYALAKAHDLVVSVTSQFEAYDVSGACASVREFLEVLTNWYVRRSRDRFWSGDQDAVDTLHTVLEVVCRAAAPLLPFTTEEVWRGLTGGRSVHLADYPVPADLPADDALVAAMDRVRQVASTALALRKAARLRVRLPLAKLVVAADEVTSLEPFAEILRDEVNVKRVELTTDVDAHGHFQLAVNARVAGPRLGPDVQKVIKAVKAGEWSEVDGAVVAAGIALLPAEYEQRLVATDPAATAALPGGGGLVVLDTVVTEELAAEGVARDLVRVVQQARKDAGLDVSDRIALTLSVPDDVAEQVRRFESVVAGETLSDTVSYGVVESGTEGTVGDGHKVTVSVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUE0</accession>
    <name>A0A7W7WUE0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_000647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="120"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="559"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="636" mass="67222" checksum="B3B2944FF461EBC4" modified="2021-06-02" version="1">MFDSVLVANRGEIAVRVIRALRGLGIRSVAVYSDADADALHVRSADVAVRLGPAAARESYLSIEKVVDAALSTGAQAVHPGYGFLAENADFARACEKAGLVFIGPSPEAIEAMGDKIRAKLTVSAAGVPVVPGRTRAGMTDDDLVDAALEIGFPVLLKPSAGGGGKGMRLVHRVEDLRDAIESARREASGSFGDDTLLIERFITNPRHIEIQVLADAHGGAVHLGERECSLQRRHQKIIEEAPSPLLDAATRSAMGEAAVSAAKSVGYRGAGTVEFIVDGTTGDYFFMEMNTRLQVEHPVTELVTGVDLVEWQLRVAAGARLDLPALTLTGHAVEARVYAEDPARGFLPTGGTVLALHEPADVRVDSALTVGLTVGSSYDPMLAKVIAHGATRAEALRRLDSALARMVVLGVTTNIPFLRALLSDEDVRSGALDTGLVERKLDSLVTSSLPPEVLAAAALERRLALGGPDPWDRPSGWRVGDHAWATWRFDGVDVRVRGDEVAVGSETYSYSAFWRDGSLVVGTSSYAAVRDGRTLWLGRDGHTWALTEDESTSAGASSTGVGGPVTSPMPGTVLVVRASRDDVVEAGQALFVVEAMKMEHTVTAPVDGVLTEVNVQAGQQVALDEVLAVVVPHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR9</accession>
    <name>A0A7W7WUR9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015103676.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16837">
        <property type="entry name" value="BldD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038099">
        <property type="entry name" value="BldD-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037664">
        <property type="entry name" value="BldD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17663" checksum="0A70D7EFBD4A14EB" modified="2021-06-02" version="1">MGDYAKALGAKLRAIRQQQGLSLHGVEQKSGGRWKAVVVGSYERGDRAVTVQKLAELADFYGVPVAELLPEGRVPSGAEPATKIVINLERLQQLPAEKVGPLARYAATIQSQRGDYNGKVLSIRTEDLRSLAIIYDMTPGELTEQLIDWGVLPPEARPAKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUS7</accession>
    <name>A0A7W7WUS7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_001082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="455"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="528" mass="54526" checksum="78002FE4312572F5" modified="2021-06-02" version="1">MTKPVVLIAEKLAPSVLDVFGDGIEVRHVDGTDRPALLAAVADADALLVRSATKVDAEVLKATTKLKVVARAGVGLDNVEVPVATERGVMVVNAPTSNIVSAAEHAVALLLAVARQIPAAHATLQNHEWKRSKFNGVELNGKTVGVVGLGKIGQLFAARVAAFGTSLIAYDPYVSEARAAQLGIELVSLDELLERADAISIHLPKTPETKGLIGAAQLGKTKRGVIIVNAARGGLVDEEALAEAVRSGQVGGAGVDVFSTEPTTESPLFGVPNIVVTPHLGASTGEAQDRAGTDVAKSVLLALQGEFVPDAVNVRGGGVGEEVRPYLPLVQKLGTVVAALSAKAPTSVTIEVRGELSNEDVDVLPLAALRGVFSRVVEEQVTFVNAPALAESLGVTVDLVKGSESANHRSLVTVRAVQADGAVITVSGTLTGLDQVEKLVGVNGRGFDLRAEGNVLLLEYPDRPGVMGTVGTLLGEAGVNVEAAQISQTKDGADAFMLLRVDRPVDNAVLDPIGAAVGARTVRSVNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW0</accession>
    <name>A0A7W7WUW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031106247" evidence="2">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="15553" checksum="F8FA18BD248672C1" modified="2021-06-02" version="1">MRTAAVAAALLLAGCSTAPNEPTASPPPSSATTSSVVTSSATTGDLYTRYGPLFKQATDSAPPSACAPAVVKSENCAALLIWIVNVAYAVEQAIESQPNPDHYAKATALIGEVKSAYDAYETCSGVDCLPHVTTILIGGGATLPVDLQLGDLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV20</accession>
    <name>A0A7W7WV20_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycine cleavage system P-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvP</name>
        <name evidence="9" type="ORF">F4559_001816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="963" mass="102883" checksum="B473BE00BD034491" modified="2021-06-02" version="1">MTQDRIPLAGLEHGTPFADRHVGPRPAELARILDVVGVGSLEELAQRAVPESIRERDLVLDLPAPATETEALAELRALAARNRTLTQMIGLGYHGTITPPVIRRNVLENPAWYTAYTPYQPEISQGRLEALLNFQTAVGDLTGLPVANASMLDESTAAAEAMTLVRRAGRSKSDKFVVDVDTLPQTLAVIETRAEPLGIEIVVADLSQGIEGLGLGGDFFGVLLGYPGTSGVVRDHERLIAEIHQADAQAVVAADLLALTLLRPPGEIGADVVVGTTQRFGVPMGFGGPHAGYMAVRQGLERQLPGRLVGVSVDADGSLAYRLALQTREQHIRREKATSNICTAQVLLAVIASMYAVYHGPDGLRTIATRAHRMATVLAAGLCENGVDVVHGEFFDTVRVRVEGRAAEVVAAARERGVNLWRVDDDVVQIACDETTTRAHLAAVWAAFGVTVSDVDGLDADTADGIPADLRRTTDFLTHPVFHAHRSETALLRYLRALSDKDVALDRSMIPLGSCTMKLNATAEMEPITWPEFADLHPFAPAEDAEGLLALITDLETWLAEVTGYDAVSLQPNAGSQGEFAGLLAIRAYHRDQGQAERDVCLIPSSAHGTNAASAVMAGMRVVVVKCDERGNIDLDHLRATVDEHRADLAAIMITYPSTHGVYEDTVREVCGLVHDAGGQVYVDGANLNALIGLAQYGKFGSDVSHLNLHKTFCIPHGGGGPGVGPIGVRSHLAPFLPNHPLQPAAGPVTGVGPISGAPWGSASILPISWAYVRMMGADGLRRATLTAVAAANYVARRLDEHFPVLYTGEGGFVAHECILDLRPLTKATGVTVDDVAKRLADYGLHAPTMSFPVAGTLMVEPTESEDLAEIDRFIDAMIAIRHEIDRVGAGEWPVDDNPLRNAPHTAASVTTGEWAHPYSREVAVFPTGTSGPKIWPPVRRIDGAKGDRNLVCSCPPLTAYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV49</accession>
    <name>A0A7W7WV49_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27173" checksum="ACF32C204AF1CAEC" modified="2021-06-02" version="1">MSCASATLVVWTSAWLHGAAAADDVLDALGVWADLHDVVADDDGTATALDLPGPDESAAGVALLLAALRRAGAGPARLILPVPGDVRGLGGRGPLSQCALRAGQAAVLPEIGIGLVPRLVADGVLRWTIFDLPSSTPGEHVPLGEAEHGLGSAMREAATALVTLDVARHRPNVREEIAALSAEQSRLTWPAGMPSRSLRVLQRAAEVNAILQVAASDAPGGAVSASATQARDEALRPLSEAVRRARLAAVDEAVRVLSDQAAGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV51</accession>
    <name>A0A7W7WV51_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="4" type="ORF">F4559_001532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36984" checksum="CEC681E63E9D594F" modified="2021-06-02" version="1">MVTTYLAAIPSPPQGVWHLGPIPIRAYALCIILGIVVAIWWGERRWVARGGVKGEVTDIAVFAVPFGLVGGRLYHVATDYQKYFGEGRNPWEALAIWNGGLGIWGAIALGAVGAWIACRKRGIPLPAMADAVAPGIVVAQAIGRLGNYFNQELYGGPTTLPWGLEIYERTLPSGIKDDLNGVATDLTPIDVVHPTFLYELLWNLGVALLVVWADRRFRLGHGRAFALYVAGYTAGRFWIELMRTDPATPVFGIRINVITSVVVFLGAVIYMLLAKSRGDREVIDRAPKSTPELESESGSDDTESQPELPASPDDDTPEKAELTASPDPSLAPEPAKRDQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN0</accession>
    <name>A0A7W7WVN0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16427" checksum="7F90BD593082EF74" modified="2021-06-02" version="1">MTVTIRPAGVGDVARIAALLGEPGYPTDTEQVGAHLDVWLADGRSVLLAAEFDGLVSGLAALHVMPLLERDGCLGRLAALVVDDSCRGQGVGRRLVAEVEREARRLDCRHVEITSSRTRAAAHRFYRDLGYPDVRDTSARFLKELDRHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP4</accession>
    <name>A0A7W7WVP4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="22996" checksum="7F1592C6BCF2721E" modified="2021-06-02" version="1">MVKPGPKRTLSEEAIVAAALELLDDRGAEAVSVRGIASRVGVAPNAIYTYFPDKAAVLRAVVDRLIGEEGPALLTGDAPWRDRLRDLALRLRADLLRHPGAAALVAGAPMDGQRALELGERLLDVLAEAGLEPDDAARASYALIVYILGAIALEAAELDPTRPAPPEAERIAARRAAFGAVPADAYPRTARAADVIAGYVSTDQFVWGLDRFVTGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA2</accession>
    <name>A0A7W7WWA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="414" mass="44387" checksum="D52526445506A888" modified="2021-06-02" version="1">MNYFGAVLLRLRLDRGMTQEELAEKSGLSARAIGNMERGTVARPHRRSVDSLGAVLGDAALRALRAVAWTPQPLRQVPRQLPPDAESFVGRCAELRELATLVSPAPGRRLGPVVVSVSGVPGVGKTAFAVRACQVVGERFPDGQLFVNLQGGMAVDEVAARLLRGLGITGDGLPADIDERAALLRSTLHDRRFVLVLDGVVDERQIRALLPNSAHCLVILTSRRTLTGLNVAKRVVLGALDLGTGLDMLRSTLGPDVVDAQSGAAAEVVRLCGGHPLALRIMINQLASRPHWCLAQLAARLRPESDRLAQLEVGDLSMRAALESVYRQLSVPAATLLLGVARAPGVELTVGLAETLLAGGPLVALRAVDELVDANLVVATGRSRWSLPDLVRLFGREVAGHARWRDRRDHRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH4</accession>
    <name>A0A7W7WWH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="46" mass="5039" checksum="FA0C49B8F910DAEA" modified="2021-06-02" version="1">MHYQAQAAHKVQLDCERGGWSHLFDSDTGKQGRVANSLLEEPANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ3</accession>
    <name>A0A7W7WWJ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="25940" checksum="AAF608EDBDC9A784" modified="2021-06-02" version="1">MENVVQVRGVSHRYRGAIALHEVDVDLRPGVTAVLGPNGAGKSTFLGVLSTALRIQRGSVDLGGIDSVRDRRRYRAGLGFLPQSFTLPTNLTVREFLGLTAWQRLVPRAGRAAAVEAALDAVDLAGRRDERISALSGGMHRRVGIAQAVVNHPRLLLLDEPTVGLDPRQRRGLRELVPTLGADRAVVISTHLTEDVAAMADRVLVLAEGAVRFDGTVHEFTAGRGRVAAHLDAAYEALVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT2</accession>
    <name>A0A7W7WWT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15021" checksum="28FAA7B9F9E71B19" modified="2021-06-02" version="1">MTAIAIDRDKPDLTGDTETQNDIFLQVFNSGDGELFDRLYRDDAISNFSGEPLTGQARRKFFVEFIGAKPVLEARVTHSYVAGDVALIGVDFTVKGTGPDGEPFTIAGKCTDVLRRVEDGRWLMAVDRPVAAGGLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY0</accession>
    <name>A0A7W7WWY0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030708788" evidence="1">
        <location>
            <begin position="31"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="23980" checksum="749009A8D25E5034" modified="2021-06-02" version="1">MDRTFLRRGVPGVAAVAALFLGTAVLPAQAAPGNAYLPHGLVKTEEHTQVREITPAVAALSAPAAFKSLNYVQQVQQQNQWCWAATGASIEKTLGVTVSQQQFCSAGKGGSGASCPNQAAQIPEIVRGFRGTGFSSQDARGPISFASITQQIDAGIPHLTGIYWTAGGGHAEVIYGYDSTNQSIQVGDPWPTYQRYQTWNYTQYRSNSRFRWNDTIVNIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX50</accession>
    <name>A0A7W7WX50_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family lincomycin resistance protein-like MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="485" mass="49561" checksum="08987D1C18217B4C" modified="2021-06-02" version="1">MTATSVSDDAAVAASGALKPGDRLVIGVLLVATFVVVLNETIMVVALPVLLGELGVTASVGQWLTAGFLLTMSVVIPVTGYLIQRLPTRGLFAIAMSLFSAGTLLAALAPGFTVLLAARVVQASGTAIMVPLLMTTVMTLVPPARRGALMGNISIVISVAPAIGPTLSGMLLDTFGWRATFWAVLPIALVTLVVGLLRMTDVGESTGAPVDFVSVVLSVVGFGGLVYGLSNIGHTGDSGPAVLWGSLGAGVAGVALFVWRQVSLQRHERALLDLRTFGFRMFTLGSSLMMVMMGLLLGTATVLPLYLQDVLGFEPLTTGLLLLPGGLIMGLLAPFVGRLYDRVGPRVLVIVGTVATSASLWVSTTFGSATPAWLVLAFHVVLSLGLAFSLTPLFSSGLGALPARLYSHGSAIFATSQQLAGAAGVALLVSVMSARVADLTASGAGKAAADTGGVRAAFLLAAVLSLAAVVGAFLIKRGKQEDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX54</accession>
    <name>A0A7W7WX54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-phosphoglucomutase family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="25056" checksum="C0F9FB7631019D85" modified="2021-06-02" version="1">MKLGLPDTTAACLFDLDGVLTSTAVLHRRAWRQVFDEFLAPKGQPPFTEEDYVRFVDGRPRYDGVRTFLAARDITLPEGSPDDPPDAQTVQGVGNRKNDLIDAIIRTEGVTPYPGTVAYLDAVRAQGLRIGVVTSSANAGKVLEAAGLTAYVEALVDGNTIASGNLRGKPAPDSFLTGAGLLDTPVDRAAVFEDALAGVEAGRAGKFGYVVGVDRAGQAEALRRSGADVVVTDLADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH5</accession>
    <name>A0A7W7WXH5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobaltochelatase CobN</fullName>
            <ecNumber evidence="1">6.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1189" mass="128264" checksum="FA08D11ACBA1DBF7" modified="2021-06-02" version="1">MEPYVILLLSTSDTDLLSARSSGADYRLGNPARLGVDDLPALVEGVDLVVVRILGGRRMWEEGLDALLAGPRPVVVLGGEQNPDAQLMELSTVPGGVCAEAHAYLAHGGPANLAELHRFLSDTVLLTGFGFAPPVAAPTWGVLDRSAPAGDGPTVAVLYYRAHHVAGNTAFVHALCDAIEERGGRPLPVYCASLRTPEPELLAELGKADALVVTVLAAGGTKPATASAGGDDDAWDVGALAALDIPILQGLCLTSSRADWADNDDGLSPLDTATQVAIPEFDGRIITVPFSFKEVDEDGLTVYVADPERASRVAGIAVRHGRLRHIPAAEKRIVVMLSAYPTKHSRIGNAVGLDTPASVVRLLKALRDNGYDIGEDLPGVDNQDGDALIHALIAAGGQDADWLTEAQLQGNPVRLPAARYREWYGTLPADFRDEIEGHWGAAPGELFVDRSRDRDGEIVLAALRSGNVVVMVQPPRGFGENPIAIYHDPELPPSHHYLGAYRWLESEFGADAVVHVGKHGNLEWLPGKAVGLSAGCGPDAALGDLPLVYPFLVNDPGEGTQAKRRVHATLVDHLVPPMARADSYGDIARLEQLLDEHGNIAAMDPAKLPAIRAQIWTLIQAAKLDHDLGLTDRPHDAEFDDLILHVDGWLCEIKDVQIRDGLHVLGQVPTGVDRVNLVLAILQAKQMWAGRSALPGLREALGLADSSRTSVDAVEERARELVQAMEDADWDVAVARSLTDDADVAAILEFAAVEVVPRLARTTDELTNVLHALNGGYVPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRLAWETGQAMADSLLERYRADHDGEWPASVGLSVWGTSAMRTSGDDVAEVLALLGVRPTWDEQSRRVTGLEVVDPDELGRPRVDVTVRISGFFRDAFPHVVALLDDAVRLVAALDEPDGSNFVRAHAQADLAAHGDERRATLRIFGSKPGAYGAGILPLIDSRNWRGDEDLAEVYAVWGGYAYGRGVEGVAARTDMETAYKRISVAAKNIDTREHDIADSDDYFQYHGGMVATVRALTGKAPAAYVGDSTRPDAVRTRTLHEETNRIFRARVVNPRWLAAMRKHGYKGAFELAATVDYLFGFDATTGVVADWMYEKLTESYVLDPENRKFLEESNPWALHGIAERLLEAADRGLWEHPSAETLDSLKEIYLKTEGDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM7</accession>
    <name>A0A7W7WXM7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="36303" checksum="E1718A7D5443C1E8" modified="2021-06-02" version="1">MTEGVAQAQAEYRVYLGTYTTWSGGGKGIGIGVADRTTGRVRSTGVISNVANPSFVVVEGNRLYAVNESPQGAVTAVSLDGATPRVLNTKPTGGGDPCHLVVFQGHVISANYSSGSVSVNPIKADGSLGDRTDHVRHQGSGPDQSRQAGPHAHQVVVDPRREYVLAVDLGTDSVYTYRLAGGKLTPVSTARVQPGAGPRHLAFHPNGQYAYIANELDSTLVVASYANGVLTPLAKLPTVPSGTPANPRNYPAEVLVSADGRFVYVSNRGHDSIAVFSVEGDTVKLLETTPVGGKFPRHLALDASGKLLFASNQNSNTVTTFTVDQGSGRVKLASTFTAPIPVCVALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXT9</accession>
    <name>A0A7W7WXT9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26329" checksum="56ED6AF593FEF318" modified="2021-06-02" version="1">MLYWLMKHVFIGPILKLFFRPRIIEGAENLPESGGVILASNHLAVSDSFFLPLKLSRRVTFPAKIEYFTGKGVKGAIKRWFFSGVGQVPIDRSSASAAQAALDTGVRIVREGKVLGIYPEGTRSPDGRLYKGKVGVAWIALESGAPVIPVAMFGTDKANPIGSKMWRPYPIRIKIGKPLDFSRYAGLSGDRFVLRSITDEIMYALMELSGQEYVDVYAAKAKETADETSAADRLPDKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY15</accession>
    <name>A0A7W7WY15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="342" mass="35960" checksum="D613BAAE72F00A6F" modified="2021-06-02" version="1">MYKTPYGTPRRTRLVAPFALLVPLVLFAGLFFGGSYLMTPDPEIEIKAGIGTGRVAGRDVVLVPYERSGPRGMWQLMFHDMFQVRLAAVDPRDGRVLWDVQLSDRLVWDAAVVAAGERYAFVATASGPVLLDLVDGSHVAGPDDIAGLGAKFVASPDAYVYDPEGRRVLTVDSDGTVLAIPVDGTAAQPVDVPGWRPEKIRRSESTTASEASLGDDKITVRERSGAPGEVLARGTGIGTEVFHGARIVVDGGRAVGAEAGRILVVHDRSVNDRSAAVSAVSLTTGAVTATLPLGSSGVDRAVVLPDGTAAIATDDEVVVATPEGRLTRLEVGDTDFFGTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY55</accession>
    <name>A0A7W7WY55_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN_SAV_6107 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040891">
        <property type="entry name" value="HEPN_SAV_6107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18726">
        <property type="entry name" value="HEPN_SAV_6107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN_SAV_6107" evidence="1">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="170" mass="17570" checksum="BD889B46DFF1DDF8" modified="2021-06-02" version="1">MSAATDFHRVPLPPSSAVALLDQARRCLREADRETAPASRFAAAYLGALRAAAAVLAARGRPHRGRAKPTSVWVLLPRLAPEFTEWAAFFDACSATRELVLAGVTGHVADREADDLVRQVGQFAVLVGGIVHEGGVGAGFAVSTCEAVPGGGVPGRVAVPTGEVVYEGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY66</accession>
    <name>A0A7W7WY66_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="5">
        <location>
            <begin position="255"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="38410" checksum="380F1D067677957D" modified="2021-06-02" version="1">MTERTETAVEQPPVPTPPPRRGLTRRTWTLVISLFSVLVLGLLGGFARVPYVALGPGPTYDTLGQVGDTDVVHIEGQETFPTKGHLTMTTVQLTDDVSLFGALGLWVSGRYALAPREEFFRPGESEQKVRDENTKAFQDSQTSAEVAALRYLKYPMKVVVAEVTKGSAAEASIEPNDRLLGVNGRTVAVAEDVRTALSTTKPGDEVEVVFERGGEKKSTRVTLGKPDDDRANGFLGVLPVERADVPFEIKISLDDVGGPSAGLMFALSIVDKLTPGELNGGNSVAGTGEINDKGEVGRIGGIPFKMVAAREGGATVFLVPAGNCDEARQHAPEGLRLVKVEKIDDAVKSLESIDAGGDAPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY96</accession>
    <name>A0A7W7WY96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P) transhydrogenase subunit alpha</fullName>
            <ecNumber evidence="5">1.6.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.1.2" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="3">
        <location>
            <begin position="144"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="37889" checksum="A1BEE59B0FD07E5E" modified="2021-06-02" version="1">MRVGIPAESRPAERRVAGTPETVSTLLGAGLAVDVQSGAGVSAHASDDDYRAAGATVVDEHPAGTAGIVASVQPTDHVDRLRAGDVTVSFLSPAFELDHVRALRDRGVTAFSLDLLPRVTRAQTLDALSSQALVAGYRAVLVAAERLPRFLPMFTTAAGTVPPAKVLVLGAGVAGLQAIATARRLGAVVEAYDVRAAAREEVRSLGAKFLELDLETQDGVYAAQQSEAALERQRELIAERVAASDVVITTAAVPGRKAPTLVTTDMLKAMAPGSVVVDLAAETGGNVVGSRPGEDVRVGDVLLYGARNLPSSLPVHASKLYAKNVANLVLMIAREGGPDLADEVLAGCCLTHAGEVRHAPTRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD1</accession>
    <name>A0A7W7WYD1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NitT/TauT family transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="30534" checksum="C8EEB11984288493" modified="2021-06-02" version="1">MATPLETDLAKVGAGLDALDAPTASGRPPLWRRFVRTGLPPLIAFALLIGVWQALWAAAFWPEYQLPSPKSVWAAVAEAIESGRAFEVLWTSVSRAVFGFLTAVVIATPLGLLVAKVRVVRAGIGSLLSGLQSLPSVAWVPAGILWFGATPSTIYFVVLMGSVPSIANGLVAGIDQVPPLLPRVGKALGATRLAAARHILLPAALPGYLAGLKQGWAFSWRSLMAAEIIATSPQLGEGLGQYLHNGSSLNDISMVIAAIFLILLVGVGIELLVFRPLERAVLKARGLTGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF7</accession>
    <name>A0A7W7WYF7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (TIGR02678 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013494">
        <property type="entry name" value="CHP02678"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09661">
        <property type="entry name" value="DUF2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02678">
        <property type="entry name" value="TIGR02678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="44996" checksum="7F7FBB35AB9F2B96" modified="2021-06-02" version="1">MSNLANQLVIAEREEVARAIRLLLATPLIGARTAPEAFDLVRRRREPVEKWFDYYCGWSLVVEPRLGYARLAKVRVADDPTRPARRHRTGRAPFDRRRYTLLCVVAAELLGVPVTTVGLLADRVVQASAVDPVLPPFDTSSRAERMAFVDALRLLESVGAVDVVDGATESFVDSADAKVLYRVDATLLMRLLVSPVGASQVAVPADEVPLRFTELLTRLSRERRYGDTDEPASEVQRNLWLRHSVFRKLVDDPVVHRDDLTPAELAYLSSPTGGQLLRRAADQAGLLVEERAEGVMLIDPDGVATDNRFPDDSGNAKIAALLLLDVITSAPGPVAVEQLRTEADALLGRFPKWAKGYRGEDGATRLVADAVDVLKAFGLVRLDSGVVRARPVATRYAVSRTSTDDVEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN8</accession>
    <name>A0A7W7WYN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction enzyme S subunit</fullName>
            <ecNumber evidence="5">3.1.21.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="42569" checksum="4C512543FCFC8E1C" modified="2021-06-02" version="1">MSDVRLGEVLNVYHGWAFPSKGCKDAELDSEPRLIRIGDFARDRSSRFEPERVQAYVAEYPRKFRLGAGDLLVAMTCQTADGEILGYPMVVPDDGRLYLHNQRIGRIEVDDTRLDERFAYYIFKTNDLNRQLYLSASGSKILHTAPDRIQACRIWLPLLDEQRRIASVLGALDDLIETNRKLMAGLAEAQLASFRRGWDGVQRRRLEEVATITMGQSPPGDTYNEDGEGVAFYQGVRDFGWRFPSRRIWTTKPTRLADRGDILVAVRAPVGELNIATEKTALGRGVGGLRAVGRQATLFQALQADTALWDIHLGTGTVFAAINKAGMAALSVPWIDDDSLESALSTMDSIISALDEEVVVLTKTRDELLPLLMSGRVRAKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW0</accession>
    <name>A0A7W7WYW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036182">
        <property type="entry name" value="PCuAC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110087">
        <property type="entry name" value="SSF110087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030752526" evidence="2">
        <location>
            <begin position="30"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="23458" checksum="3B2753D06155E7BD" modified="2021-06-02" version="1">MGRAQQKSPTRRLALVAAVVAGFGLTAAACGAGQITQTDRQVAAVDGASGDAGTVAVRDAQLAFPVAEGHYASGSDATVVVTIVNNGVDLDKLVSVTSAEAGEGVLEGDVQLEPGTAIKSEADGASGHATSSSSAHATTSAHATSESSAHSTTTGSAAPTTASSGKPSSSASSARPTTTTAAKAEPGTVKIVLKGLRKDVRPGETVAVAFLFEKGGQVVLQVPIGATPEARVEGKSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ62</accession>
    <name>A0A7W7WZ62_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">F4559_005822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="128"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="44706" checksum="BB50D2A6F7EC1543" modified="2021-06-02" version="1">MSEEKSSPEHPWPVRTVARKIFDWINRLGDVWVEGQVTQLSARPGTATAFLTLRDPSVDMSMQLTAPVGLVRDLQLTEGSRVVVHGRPHFFPNRGTLSLRVDEIRAVGVGELLARIERLRKLLHAEGLFDPRRKRRPPFLPTKIGLITGRASAAERDVLTNAHARWPGARFRVVNVAVQGALAVPQILTALSTLDRDPEVDVIVLARGGGSVEDLLPFSDEALCRAVSRCRTPVLSAIGHEPDSPLVDHVADLRCSTPTDAGKRVVPDVAEEAERIRQLRDRSRRALYGWVDRERKLLASLRTRPVLADPHGPLDRRAEDVDRLRERGRRAIRNRLDSEAAGLAATTARLTTLGPAATLARGYAVVQVVGDGVVRSTADAPAGTRLRIRVADGAVHAVVEEGDGGGRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZK8</accession>
    <name>A0A7W7WZK8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35630" checksum="8BCFBBEA1EC26073" modified="2021-06-02" version="1">MAEVKGGGESTVTVLLALAVNLAIAVMKAVAGVVTGSAAMMSEAAHSVADTLTEGLLLTALRRSDRPADRRHPFGYGKERYFWSLLAAVSIFVSGAVFAFYEGFRTVFGTPEEQSSPVVGYVVLAIAFVLEGVSWSQAVRQVRREAREEGRPVLVYLRLSDDPTVKTVFLEDSAALVGLLLAFGGLGLHHLTGSSVWDGVASLAIGVLLAFAAYVLASTNRGLLIGRQADPKLVRGVWTYLRSGVPEIEEVVDLLTMAVGTDRVLLCVRVDFDDALGAADLERACVRVSAELRTRFPELDEVFIEPVPRTDPELRSRVLNRYGDAFRSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZN4</accession>
    <name>A0A7W7WZN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="33989" checksum="3813A8E3F1CE412D" modified="2021-06-02" version="1">MRMLVLGGTVFLGGSVAAEGVRRGHEVVCAARGVSGNVPDGAVHVPVDRNTGLDALRGIDVDAVVDVATMSVTWVRDALRVLGHVPHWTFVSSCSVYADHGTPGSRTTLPPLEDDPGAPMSPDRYGSVKVASENAVRDTCGDRAFIVRAGLITGPGDKTDRFGYWPNRLSRGGRVAVPDVPDQAAQHVDVRDLAAWVVDAAERRVTGTFDGIGPADPLSLVLGEIAGATAPQGTELVRVPTDVLEAHGVTPWSGPRSLPLWLPASHRALMFRDPGPALAAGLRTRPTAETAVDALAYERSLGPDRPRRAGLPPDVEAGLLTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SX99</accession>
    <name>A0A7W7SX99_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="32" mass="3246" checksum="94DC6572E8AE701A" modified="2021-06-02" version="1">MLEVAALGLPDGEAESLADGTAMVARFRALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXT9</accession>
    <name>A0A7W7SXT9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">F4559_000312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10314" checksum="80D2DC4FC1154324" modified="2021-06-02" version="1">MSVNIKPLEDKILVQASEAETTTASGLVIPDTAKEKPQEGKVLAVGPGRIDDKGNRVPVDVAVGDVVVYSKYGGTEIKYNGEEYLILSARDVLAVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYA2</accession>
    <name>A0A7W7SYA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="37132" checksum="CC907EFB1CB00E30" modified="2021-06-02" version="1">MSPLIGAEAVVLVGGKGTRLRPLTLSAPKPMLPTAGVPFLTHLLSRIREVGITHVVLGTSYKAEVFQEYFGDGAALGLELEYVVEEVPLDTAGAIRNVAHRLREPDVLVFNGDILSGVDLRGVVETHRSTQADVTLHLVKVDDPRRFGCVPTDAEGRVTAFLEKTENPPTDQINAGCYVFRREVIDAIPVGRPVSVERETFPGLLEAGARVQGHVDTSYWLDLGTPAAFVKGSADLVRGIAPSAAVESPGEAVVLAGARVDPGAVLTGGTTVGAGCTVAAGAVLDGAVLFDGAVVGENAKVSRSVLGAGALVQTEAVVRDAVIGDQAVVGARCELLDGVRVWPGVALPEGGVRFSADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP1</accession>
    <name>A0A7W7SYP1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="39182" checksum="0392D80E5C874355" modified="2021-06-02" version="1">MPESTVDGLTVAALTRVLRLAVVLVGMVTLIGLGIPEVLANTPRYAHVALEWAAVSVITVVAVVLCGVLWARWEPGWPLRITLLAAVYGASWLAVAGVPVELLASEAEWSYGLVGWFALALLMDRSPLAAAVFLSAHASVDVLRLLWYDQDPVRGSVVTVLVLTEQLTVVAAVRVLRRIADRARETAAATARGRTAEEIAERLQADRRARYADLADTTGPLLARIATGHPVDAETRRRCLVEAARMRRLFAEDDEAADPLLHELRGCADLLDRRGVTVYIGTCGDGPTVPADVRRALTDPIMRTMIAARGRARVTVLGSPEEVTVSVVADADPGEVAERPAAGVRVTRFDDDGQVWVEATWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ7</accession>
    <name>A0A7W7SYQ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoC</name>
        <name evidence="5" type="ORF">F4559_000176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="4">
        <location>
            <begin position="105"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="27153" checksum="D28E3BC8BE6CBD6C" modified="2021-06-02" version="1">MADEKNPEALSSADLTPAEAAEHQAHGGVVAGRARQGMFGISGSGDTSGFGGLRLPAHVAARSERPYGGWFDEVADELAAAIREKGLPDDTVQQVTVAHGEITFYLRREHLVDTARILRDDPALRFELCSSVSGVDYGADAPQRLHSVYHLTSMTYRRRIRLEVAVDVDDARIPSVVSVYPTADWQEREAWDMFGIVYEGHPGLTRILMPDDWDGHPQRKDYPLGGIPVEYKGAEIPPPDQRRSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT6</accession>
    <name>A0A7W7SYT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="36" mass="4072" checksum="B08BB6CBA8F523D8" modified="2021-06-02" version="1">MLRDDHPEPLGAVDDDRLRLISTCCHPALAVESRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX4</accession>
    <name>A0A7W7SYX4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEFIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEFIR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19926" checksum="879943228A6C34D3" modified="2021-06-02" version="1">MRTSLPGTGKLVRELWLLLRRNGVDARWDGLVAQQPRDWALWTAEQIREADQVLVIASAAYRERAEASVGRRVQWEARLVRDAFHADPHRLDRFLPVVLPGQPTQGVPDFLAPNSSTVYTVEEFTPAGAEPLLRFLLGLPEEVEPGLGGAPDFPTRAHRSSDTGAPPSGAVADPNGAGSSVSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN9</accession>
    <name>A0A7W7SZN9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="27366" checksum="88BEFDB95D4D2C20" modified="2021-06-02" version="1">MNPPDEPPTGLIAGVRAAGREPEPERTGQRWGFGAFLLVEAVFVLTAVFITALARTSGTDIGGSVAFVLVGSILPTVLAATLAVVITRVRGNGPLVDLRLHWNWADVKVGLKLGFLGLVLTYVAALLWSRLVGDQNATSAIGELVDGTALPLGAAIGMFVYVCFLGPVCEELIYRGLLWGAIERQGWSRWAAFVLTTLIFAAGHLEPLRTSLLIVIALPIGIARLITRRLTASVVAHVINNFLPGLMLLLVSLGVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZR2</accession>
    <name>A0A7W7SZR2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ORF">F4559_001015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="247"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="730" mass="81574" checksum="8630D8F04D414B05" modified="2021-06-02" version="1">MYAIPPEDVDRLLAGSHHDPHSVLGVHHGAESVVARALRPGASAVSVVAGDKRFPLDRVADGFFAGALPEHPGDYRLEVEYGTRTVEVDDPYRWLPTIGELDLHLIGEGRHERLWDVLGAHVRRFDTADGEVTGVSFAVWAPNARGVRVTGDFDGWDGRANPLRSLGSSGVWELFIPDAPVGTRYKFRVLGQDGTWHEKADPLAFATETPPHTASIVTRSEHVWGDAEWEARRDATRWENAPMSVYEVHLGSWRQGLDYRELADELADYVVAQGFTHVELMPVAEHPFGGSWGYQVTSYYAPTSRFGTPDDFRYFVDTLHRRGVGVLVDWVPAHFPRDSWALARFDGTPLYEHGDPRRGEHPDWGTLVFDFGRNEVRNFLVANALYWIEEFHVDGLRVDAVASMLYLDYSRDEGQWAPNQFGGRENLDAVRFLQELNATVYKRHPGVVMVAEESTAWPGVTRPTHLGGLGFGFKWNMGWMHDTLHYLSREPVHRSYHHNEITFSLVYAWSEHFVLPLSHDEVVHGKGSLWQRMPGDDWNKAAGLRSLLAFMWAHPGKQLLFMGGEFGQRGEWSEARSLDWDLLESDYHRGVQSLVRDLNHAYRALPALYSADSSPDGFQWIDANDSGGNVLSFLRLGEDGSRLVCVANFAGNPHHGYRVGVPNAGVWREIVNTDSTVYAGSGVGNLGTVEADPDPWHGRPASLVLNLPPSGVLWLTPDPQPADGPPDDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZW5</accession>
    <name>A0A7W7SZW5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031563737" evidence="3">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26487" checksum="62FBB90CE44BC19D" modified="2021-06-02" version="1">MRLATLLVALLVFGGGTAAATGERVVGGSRVAITDHPWVVYLTDSAGFQFCGGTLVAPRKVVTAGHCVVSRSPGTTRVVAGREDKRTRQGEVLAVEEIWVHERYDGADQGSDVAVLTLGSSAHQATLPLVSHAESELYEPGTLATVLGWGRVSELGATSRFLLAATVPLTTDEVCGEAYPQYDPSAMVCAGRPDGGVDTCQGDSGGPLVAGGRLIGLTSWGEGCARPGKPGVYTRLESYLDVVRPHLAEVTTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N7</accession>
    <name>A0A7W7T0N7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lspA</name>
        <name evidence="9" type="ORF">F4559_001480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22140" checksum="57D46C29308338F1" modified="2021-06-02" version="1">MSTDEDAGTGTGDAATADSPRTSETSATDPGTGDAARPLPKRRVLLLALIAPLVLALDVVTKIVAVDALEHEPPVELFGGLLYLSLLRNPGAAWGMAEGATVILALIACGVVGFIIWIARRLRSVGWAIGLGLVLGGALGNLSDRIFRAPGPLRGHVVDFLSIVEPYGTFFPVFNVADSAISVGGVVIVLMAMLQRDYDGTRIEKKPARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X2</accession>
    <name>A0A7W7T0X2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20930" checksum="E558A6047EF19332" modified="2021-06-02" version="1">MTDHVRTAQPFGRTVGAEIARQVQQHVHPAVAPRRDDAALATLLRARQRGDAQRQEPWVRRAPEAPPKAPHADVIQQLAARLVPQSLWAHVEPLIPPAKVRRQGGGRGRVSDRAIFTAIVFVLTSGCAWRHLPATFGVTVPTVHRRFQEWTDLGLWSALHTVAKSGTAEDSTWLLLVVEAAERRGAKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y3</accession>
    <name>A0A7W7T0Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="61"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="459" mass="49048" checksum="277B27B4B7840976" modified="2021-06-02" version="1">MSDGVFDEGLFGVAEEVKAERIAANAPLAVRMRPRSLDEVVGQEHLLGPGAPLRRLVEGASPASVLLYGPPGTGKTTLATLVSTATGRRFAALSALSAGVKEVRAVIDEARRRLVRSGEATVLFIDEVHRFSKTQQDALLGAVEDRIVLLVAATTENPFFSVVSPLLSRSLVLQLRSLTDDHVRTLVRRAVGDERGLGGRIEVAADAEDHLVRLAGGDGRRALTALEAAADAAEGGVLDLATLEKTVDKAAVRYDRQGDQHYDVTSAFIKSLRGSDVDAALHYLARMIEAGEDPRFVARRLVIFASEDVGLADPTALQTAVAAAQAVQLVGLPEGGLNLAHATVHLATAPKSNAVTKAIGLAIDDVRKGAIGAVPAHLRDGHYAGAEKLGNARGYRYPHDVPEGVLTQQYPPDDLVGRDYYTPTNRGAERVVAERLPRLRRVVRGDENSRADRPGRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T142</accession>
    <name>A0A7W7T142_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">16S rRNA (Cytosine967-C5)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.176</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="7">
        <location>
            <begin position="189"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="292"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="472" mass="50199" checksum="27B5DDDD7C801AD7" modified="2021-06-02" version="1">MTQRSSRPSRPRGPHPPRRRSGPPRPPVEDPARQAALDTLRAVRQRDAYANLVLPGLLRDRRITGRDAALATELAYGTARAQGLLDAVLAACTDRPLSDVDGSVLDALRLGAYQLLRTRIPAHAAVASTVDLVRAGLGSGVAGFVNAVLRRVSAQDEPAWIDEVAPDEETDPVGYLALAHAHPRWIAQAFAESLGTRGEALRAALAADDARPIVHLAARPGECSADELAAMTGGDPAPFSPYGVHLESGDPGDLDPVREKLAAVQDEGSQLCALALTRVPVDGPDERWLDLCAGPGGKAVLIGALARLGGATLDAVEKAPHRAELIRKAAGDLPITVHVADGRDPGLPGGYDRVLVDAPCTGLGALRRRPEARWRRQPSDVAPLTRLQRELLTSALELVRPGGVVAYVVCSPHLSETVGVVADVARRTGARQLDTREYFPDVPDLGDGPHVQLWPHVHGTDAMFCALLRRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T193</accession>
    <name>A0A7W7T193_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="427" mass="46618" checksum="5D59BB80F69EA0BC" modified="2021-06-02" version="1">MAAKIGVESGTVGRWERGETDPTPGLRRTVASALGLSFAQLDAVLAGAVRPGPAVGSVRASQEDWLRTRRAPGVRGRELTELAAWLYPRADRAPGGHVLAGPGWLPPEPIPVESVGLHRVTDFPAFAPPPVPVDHLLPLGDNGSRYRHYSRAVRDLVRPRLLENRPSYRLVDVDTANGLRLGFGSTTFFETFDLKQLVAHEFKHAWLAGGGRPPGFGDLPLRTAIANPFDPARLLMSPGINTLTLRRGTRREGIGFVLHERDGGKVADGGGLCHVMPAGEFQPSSAADQPGDFSLWHNALREFSEEFLGNSEHDGSGRPIDYRWDEPFFRFEAARERGTFRLWHLGLVIEPLELGVQQLTVAVVDGPEFDALFSDMVAVNDEGGVVLDRSGARYLPFTADAVDRLEPRLSATALTLLRLALDRGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D0</accession>
    <name>A0A7W7T1D0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiopeptide-type bacteriocin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="47"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Lant_dehydr_C" evidence="2">
        <location>
            <begin position="737"/>
            <end position="979"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="989" mass="107718" checksum="8814C8B9C7E7C0A8" modified="2021-06-02" version="1">MPAEDDYRHHGTGVLRAAAQTVAVDRWPDPDDADDCRSWLADAWTLPGIAAAVRHASPVLSRRVEAILTADTVTARDLNRATSAVIRYVLRADGRSTPFGTFAGVGTVSVGDSAHVAWRPDHRPVVRAEARWLHEVVRRLEQCPELVARLDVTVDDTAEVRAGRWISPGPETVSVRLTSAVELVREQARTPVRFGELADALRRAFPTAGDPTGVLSSLLRHGFLLTSLRAPGTVTDPLGHLVDRLRHADAAGSPMARLADDLVHIHRQIRAHNDVPDEQARIRLADRMRQVADSVRTPLSVDLRLDAHVRLPHAVAEEMCRAAGVLARLVRQNTGSRDWRDYFAAFVERHGTGTLVPVADVVDRDHGIGLPGGYPGGAPQSGRHVFSDRDALLLAVATEATARGDSEVNLDDALVDRLAAVCGGREEIPPHLDLGAQVHATGPDALDRGEFTLTVAPGRAAGTLTSRFTTLLPEAALDTVFSALPTTTTDAVPAQLSFTPIHPSAENVCRVPAYLPQRVSIGEYADDDAIRLDDLAITADRHRLHLVSLSRRRVVEPQVLHALAPKQQPVAARLVGELARALDPGWIGFDWGPVAETLPFRPRVRSGRAILAAASWRLTATDLPEAPDAHDEALARWRATWRCPARVRLRDFDQLLPLDLDVPAHRRIVYRHLRRHDHAVLLEGVDPAADGWIGGHAHSVVLPLTTTRPPAPAVPVHALPVLTAGHGHPPGAPGSSWLYAKLFVPADRMDHLLAQEFPALLDDLAGRPWWFVRYPRPRDGEEPDHLRLRIRVHDDATAVFTAVAGWAAGLRARGRIGRFALDTYFPEIGRYHAITAAEDVFATDSRAVLAGLVHPPDDDLAATVPTALTMFDLATAFLGSRTSAADWLHRSSPAASPERADVTAITRLVREGRPAPASRDVTEAREARAGALARYRHALPETADVDAVLHSLLHMHHNRALGVDRDREAVCLRLARQAAATWRATGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F5</accession>
    <name>A0A7W7T1F5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7384" checksum="76C366C90FC7E069" modified="2021-06-02" version="1">MTNPFDDPEGRFHVLVNHEDQHSLWPSFAEIPAGWTAVFGPETRDACVAYVEENWTDLRPKSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S2</accession>
    <name>A0A7W7T1S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome accessory factor C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="149"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="330" mass="35994" checksum="A788C31C8C583D52" modified="2021-06-02" version="1">MNNSSANERLPRLLALVPYLLARPGIPVEEAAADFEVTPRQLRKDLELLWMCGLPGYGPGDLIDLSFEGDTITVVFDAGMSRPLRLTAAEATALLVALRALGETPGIADQAAVRRAVAKIEAAVGKAQPAGVAVGLGLREAPETTPVRDAVSDGVRRGRALRLRYYTPSRDEITDRVVDPMRMLLVDGRNYLEAWCRTADDVRLFRLDRIDRVVVLDEAATPPSHATPTDTSEGLFQPDSSQRTAVLVLEPDGRWIAEYYPVEDVTELGEGRMRVRMRYADTAWMVRLLLGHGGEVSVERPAELVAAVTRQAEAALRRADHLPATGPQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T280</accession>
    <name>A0A7W7T280_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutaconate CoA-transferase subunit A</fullName>
            <ecNumber evidence="1">2.8.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.12" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018730">
        <property type="term" value="F:glutaconate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28407" checksum="E132D5EB6D1F0583" modified="2021-06-02" version="1">MGSLAEAVADLVHDGDVVALEGFTHLIPVAAGQEVIRQGRRGLTLVRMTPDIVYDQLIGAGCATKLVFSWGGNPGVGSLHRFRDALEHGWPRPLEVEEHSHAGMANRYVAGASGLPFAVLRGYVGTDLPNVTSTIKFITCPFTGEQLAAVPALNPDVAIIHAQRADRAGNVQLWGLVGVQKEAVLAAKRSLVTVEEIVDELTPVPGAIVLPSWAVTRVVAVPGGAHPSYAQGYSERDNAYYAAWDPISRDRDTFTEWLTALKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T297</accession>
    <name>A0A7W7T297_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane carboxypeptidase/penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030651605" evidence="1">
        <location>
            <begin position="26"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="250"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="523" mass="53357" checksum="04AA62832D601496" modified="2021-06-02" version="1">MKTRTKRLVLAGAGVLAVAAVVAGVIEIWPGTPAGKPASPGTKVPPAAVAQEFVTALATDQFAQAAGTTDAPDTAREALTLLRRNMVDARYHARLGAAPTTAADATTATIDAEVTWTLVGGALFKYPLRVELRRADERWRVHWASTVIHPELAEHQSLAYHLVSGDGALHGRDGKDPQGLPAGLRDAATKAVGSLDGKVGFQVTAVDGAGAAGKVFLDQKAEPGQVATITIDPAIQSAAQQAVDSVPQDGALVAIQPSTGEILAIAQHGSGGAQSPVALTDRYEPGSTFKIVTAAAALNAGAVTTTTPVACPGTDTIGTRTISNEDKFDLGTVPLRRAFAASCNTSFAKLAADLPADALPDAASWFGLTSDYTIPGLTTNTGKIPSSPSVPERVESGIGQGRVQVTPFGMALVAATVANGSTPTPRLVRELPAEGGRATPPPAGVVAALRTMMGDVVTGGTARELAPYGNVRGKTGTAQFGDGTHSHGWFVGYQNDLAFAVLVVDGGSSKAAVAVTSRFLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D9</accession>
    <name>A0A7W7T2D9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CPA1 family monovalent cation:H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="PTHR10110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="7">
        <location>
            <begin position="9"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="534" mass="56160" checksum="670BEA2F641A3B0C" modified="2021-06-02" version="1">MLEIVAVTVLGLVVIAAAAVLAPKLGVAAPLVLVLVGLALAVTPGIDDVEVEAEWILQGLLPPLLYASAVSMPAMNFRREFGVIGGLSVLLVVGSAVVLGLLFAWLIPDLGFVWGVALGAIVSPTDAVATSIIKGTSVPRRAVVILDGESLLNDATALVLLRTAIVATAAAFSFWGTLGTFAYAIAVAVVVGAVVGRVNLAVRRRVEDATVNTILSFTVPFVAAVPAELLGSSGLVAAVVAGLVTGYRGPRVLPPSHRMSDAQNWAMVELVLEGVVFLGMGLQLSTVLGGMRTGVGEAVGIAAGALAVTLLVRAGYVAPLLWGLRRRASRWRERQPHIAKMGERLDAGDLTPLRGRRPSERRARRLATRVRRSLADIDYLLDHPLGLREGVVVVWAGMRGAVTVAAAQTLPEDAPHRPLLVFVAFAVATLSLLVQGGTVGPLVKILFRNRAEDGSEQDDERRQILALLQETAHGISRSSDMSVKQHKLAIVKAQRDALLDARDDGVFDADTLSNALRTLDAAQLTLELRGGPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2I9</accession>
    <name>A0A7W7T2I9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="20701" checksum="60F2F6C74B6DCED5" modified="2021-06-02" version="1">MECIWRGKPGEWYREPGVRPVAVLAPVTAVLVFLVPGVAFWTGVGVAVFAWRGISKWTNTRRLVVAVEVDRDARQLLVRSRSGKTHTYSLDKWLVVRPIQRGHRTVVVHEHEDDEVRETDEIVVHLDIAMDTFTLYHSMTTQSLLRTLDAFRGIGEKVRIKKVTDRRTTFYDVEADRPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z0</accession>
    <name>A0A7W7T2Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-3-amino-3,4, 6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase/N-dimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.234</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.234" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19121" checksum="6AB719B1236618B3" modified="2021-06-02" version="1">MAGVEISDAMRRIAAGKLPGVPIHVADMRDFDLGERFDVITCLCFSIAYTRGEDELGRVAASIARHLNPGGVVVVEPWWFPERFLDGFVTGSVVEDDGRVVSRVSHSVRDGRTTRMTVRFTIADRSGIREFTEQEVLSLFTEAEYASAFAHAGLRVEHLAGPPNGRGLFVGVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T374</accession>
    <name>A0A7W7T374_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="269" mass="27336" checksum="EB50CB9778B23065" modified="2021-06-02" version="1">MGSLDGKVALVTGAGSGIGEAIALRLDAEGARVAALDIDAGAAGLTAGLVRDGLAVTADVADSTRVDAAVARVVEHFGRLDVLVNNAGIRGGTEADEAFGRLAKRIEESASGTPTTTIDATVNISDDAWHRMLSVHLDGTFYGTRAAVRHMREQGDGVIVNITSICGLTGCAHIPHYSAAKGGIEGLTKAVARDVAPLGIRVNAIAPGYIDTPLGDVIAPVVRADLNRQISLGRFGQPAEIAAVVAFLAGPDGAYLTGQTISPNGGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3B7</accession>
    <name>A0A7W7T3B7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative LLM family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="37885" checksum="BE34279F4C9735B4" modified="2021-06-02" version="1">MSTNMQLGVYSFADRSPDALTGEQLSVADELANTVERIKVADQVGLGFYGLGEHHLENFASSNPATVLAAAASVTEHITLSSAVTVLSTEDPVRVYQQFTTLDQLSRGRAELLAGRGSFTESFPLFGARLEDYDELFEEKLALLLRLDREHPITWSGKFRSPLENAEVYPRPYRDRLRITIGTGGNPESSIRAGLLGLPVVYAVIGGEPERFAQLAQLYRRAGEAAGHRPEDLHVTMSAIGLIAPKSQDAKDIYYPYWLQTMKYGARARGWRVPSRADYDAWTHDANSIFAGSPAEIAERLAAVGELVGADRYAMHMDWSGVPHRHVVTAIELLGTEVLPLVGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E7</accession>
    <name>A0A7W7T3E7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HAF family extracellular repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031434940" evidence="1">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="372" mass="38733" checksum="631617FA1D021441" modified="2021-06-02" version="1">MRWLSVSTALIALVGLAPSAGADVGFEELRPALGEVVLVTAINEAGQTVGSEWAPGWYRGSAMRWEGTVPGSMGSGNALGIDERGAAVIVYGNKQGGAEFTYIDVWADGVRTRRTPPPSNGYGPMTVRDLGGGALPIGYDNPKDPTASYHPDQAAVWRDGTYSDITFGEKGTVRHRAVNGIGTTAGALDPKGGVPYAFRCAAVGCTRLPAAGAGGYYDVKAINDADVVVGDWRATSQVTHVVVWTGDRAVVLPGEGAGAADNVRALNENGDVVGWRTENGVRRATLWRGGRLVDLGASGASEAVAVNDRGDVVGWHTVEGAPHPFHWRAGTLSGLPTPENVPAKPKALNNAGIAVGSTLVARSGRSFRWTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z5</accession>
    <name>A0A7W7T3Z5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglut_core3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032708">
        <property type="entry name" value="McjB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13471">
        <property type="entry name" value="Transglut_core3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Transglut_core3" evidence="2">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15208" checksum="4AF51469A3AF421D" modified="2021-06-02" version="1">MTTTEAFTTSPRGGPGCRAAATVGLVAAMLLLRLAPFRVVVAAARLARRVGRRTPDPVHAADLVDAVRHTGRWWPTRVACLETSLAATLAAAVTGRRPVWCLGARFRPEPVEYHAWVCLPDGTPVGEYLLAGRHHHATLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T475</accession>
    <name>A0A7W7T475_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YbjT (DUF2867 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="25289" checksum="11604250CDA0710E" modified="2021-06-02" version="1">MRVVVIGGTGLIGSKVVAWLEGRGHDAVVAAPSTGVNTITGKGLTEVARGADVLVDVSNSPSFADDDVLAFFRTSTANLIGAAQGSGIGHYVALSVVGADRAPDSGYLRAKAAQEQLIRDSRLHHSLVLATQFYEFAAGIADAATTDGVVRLPPGAVRPVAAADVADLVARTAVGPPLDGVVEIGGPEVFGLDTWIRTFLAAKGDPRTAVTDPRARYFGTVPDERTLVPGPGAVTGRVRLADWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T499</accession>
    <name>A0A7W7T499_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiosulfate dehydrogenase [quinone] large subunit</fullName>
            <ecNumber evidence="6">1.8.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.2" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043831">
        <property type="term" value="F:thiosulfate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20252" checksum="662A078D56F48E55" modified="2021-06-02" version="1">MTAFVHSTSTVGSAERVGTRVGAGAAALAVLRVLIGFVFLWAFLDKLFGLGYATKAANAWIDGGSPTKGFLGRVAVGPFEDVFHAWAGTWWADWSFMLGLLGIGLAVVLGVGLRVAAVAGTVMMAFMWVAEWPPARFTSAGAATMSTNPVVDYHVLYALALIVVAASGAGAVWGLGRWWASLPVVRDHAWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A6</accession>
    <name>A0A7W7T4A6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="42443" checksum="C0548943F9666ABF" modified="2021-06-02" version="1">MGQGLGAAFPALRERHYRVFWITGLVSNTGTAMQAVALDWYVLTITGSGTAVGWAIGLQYAPVLLFGLWGGSVVDRFPRRTVLLVAQTLYALQAATLAVLVFTGTAQLWAIYALSFLLGSVFLVENPTRLSFVSELVGRTLIPNAASLNIASLTAARLTGPAIGGLLITWVGPGWVFAVNFVSFGVVIGGLLSIATRAAPRRATISASAGVTYVLGRPGLVGVLAAFGVVATFGLNFPITLTMFAGEEFGLGAWGLGVMSTAMAVGMVAGTVTVGRRVFPSVRTVMVAAVAFGVLECVAAVMPVYPAFLVVLAATGFAVMSLNTFVSAYVQLDVTEAVRSRVMAIYTVISMGGTPIGGPIIGWVSEHAGVRVGMAAGGVVSIAFGLGAALWFARRGGLAVMPSPTSRAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4D3</accession>
    <name>A0A7W7T4D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5134" checksum="F309110D122A678C" modified="2021-06-02" version="1">MTTAAPYSPRWSIGDALVLAVGSGRVGRPGASYRPGAVWRPVRCCSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F2</accession>
    <name>A0A7W7T4F2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">F4559_003695</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="584"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="662"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="730"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1099"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="18">
        <location>
            <begin position="1253"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="12">
        <location>
            <position position="1148"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="11">
        <location>
            <position position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBB4966336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1350" mass="142049" checksum="B49059529136A0B5" modified="2021-06-02" version="1">MDGFDDGPHPAISRAWLLVHCLGVVWCVVADDGAVTTGAVAASWSIGTVLLLGGVGGGPAAGPPWRFAAAQTAVVVGASYHLGVVFVVGALVFAWTVARRLPPPGAVDVCLVAVSTGMLVWTLPGGGAVPESAGAALAFAATVVAASAPPMPGDWWLVGWSACALWWVVSPRFGVETGPEILVVLPALLFLARRPRSRDPVSAPASAGARGLPVAVVCVLPPAALLVFGVVEGSARELPVIGAGTVVTTGLLLARSSWSAADPRLDHAMRAHLRRGAVRVCVGFALSALVPLAVLTGVVVREATLTEEREVHANLVGRAEGAVAAVADRMAAARRLVESAARRPELAGALSTGDGTAVRAELDSLREQDVGFLASWVLDPAGVLVSASPPRPQSPGTRFDHRDYFRGAIAADGAYVSEVYESAGVDRTRVVSVAASVRAAGRVVGVIVAGYPIGSFTDLLEHTTADGTSLIVTDSRGTAITDEPTAGPALPRQQVDEALAGRSGTADVLQAGHEVLVAYRPAPSLGWAVVVGVDGAQAFADLRRMTGRVVSVALVLGLLMTGVLVYAARNERKRRLAERLLARRQAETRDILQAAGDAFVSISASGRVTAWNARAETLFGWSAAEVRGRPLVDLVVPSELRADHLEGIAAAVAGGRPRLLGRTVQTTARHRDGTTVPVELTLWRSGQDGNPTFSAFIRDVTERRDHEEVLARARDQALAASRTKSEFVANMSHEIRTPMNGVIGLTSLLLDTRLDVRQREYVTMLQHSADALLGVLDDILDFSKIEAGRLDLDPVDFDPRQLAEEVVGVMAPAARHKGLGITALCDPVLPPPLHGDCLRIRQILTNLVSNAVKFTAHGEVVLAVEVRPLDGEAGHRVVCTVSDTGIGIPADRLSGLFEAFTQVDASTTRRYGGTGLGLAICRELTGLMGGRITVDSAPGAGTAFRVDLALRPAHACPPDPPPAPDLTDRVVRLVTDHETGRRAVSDLLLAWNATLDHVAVDVPQARATRPDRAADLVIVAVRRPGREIVDHAAAGVDPSRVLVLAWADTAWTSGDPAGRVSMPVRARTLARAVVDVLDPHGDSAGERPDERPAPMTGTVVLVAEDNEVNQRVVAGMLEALGCAVEIVGDGAQAVHRVARGGYDVVLMDCQMPVVDGFEATRRIRGLPPPYDLVPVVALTASVLESDVRRCYEAGMDAFLAKPLRRERLEACLRELVTPPSPPLPRSARFEVMRADGHEGLVDPGTLDELRLLGPAAVAELLELFTATALQKVAAIRRAVADGDLDAVQRLAHGLKGSSAQIAARKLAVFSSALEHAARSEDRRGVEALVDDLAQVAVTSCEALRATLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M2</accession>
    <name>A0A7W7T4M2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8018" checksum="F080746340E7787F" modified="2021-06-02" version="1">MIALIATFLALAVIQFVLALADGLWWPVVFGLLLVVAASALVPSARARHEPSANAPDPPNHLEPRADNHTAGQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N9</accession>
    <name>A0A7W7T4N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23099" checksum="9F2DA71391F4F9A3" modified="2021-06-02" version="1">MTTTVLVVDDQAMIRESLRVALDSRPDLEVVGEAASGAEAVALATRLSPDVVLMDIRMPGMDGLEATRRVLDSHATTKVLVLTTFDHDEYVYGALQAGASGFLLKDSPLSDLINAVRVVSAGHSLFAASVTRRLVASFAARARPDDATLRHLTPRETEVLRLVARGLSNTEIADALTIAEQTAKSHVSRVLTKLNARDRAQAVVVAYESGLVAPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S3</accession>
    <name>A0A7W7T4S3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16515" checksum="F8923DB52995051F" modified="2021-06-02" version="1">MTSKDPLAGAELTYLLGISFQLLVTEFDRRLGELGYTDLRPVHGFVFQLLKNGGLTGTELAEHLGVTKQAAGQTVAYLEDRGYVSREEHPGGGRRRLVVLTDRAREHLRVAGRVMRELESTLPGGEALRVDLAAVVRSLAGTALPPLRPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T5</accession>
    <name>A0A7W7T4T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5248" checksum="E3A0CA270B82656A" modified="2021-06-02" version="1">MTLDPVLAAAVPRWGDPDPESRHPPSSTSRWAEVRIGTRERGIPGDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T529</accession>
    <name>A0A7W7T529_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LYZ2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031130253" description="LYZ2 domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="3">
        <location>
            <begin position="40"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="527" mass="55032" checksum="6DA7268E579752E7" modified="2021-06-02" version="1">MTDRRTGRVVRALVMVTAALAAAAGTAGADPLPSTDQVGAAAVDPAAYIAMAGPVAQAVMAEYDIPASVILGQAGIESRWGASGLTTKDNNHFGFKCAEPDRPGPIAIGCHKYVTDECRPDGSCYTTTAYFRVYASMRDSYRDYGRLVTTVDAYAGALPFRHDPDRFIAAVAPVYNNRPSYASDVISVMRTYNLYALNTIGPSRTDVIVGGGGTDFTGDGKTDIATFSRGTAADVFVAASTGSGFAGTSVKWHEFFATGNEIPLTGDFNGDGKDDVATFTRGTAADVFVALSTGSSFAGTSVKWHEFFAAGDEIPAVGDFNGDGKDDIATFTRGTNADVFVALSTGSSFAGTSVKWHDFFAAGGEIPGVGDFDGDGKDDIVTFARGTGGDVFVARSTGSSFAGTSVKWHEFFSVNGELPSVGDFDGDGKDDIITFTRGGRGDAYVARSTGTGFGPSSVWHGHFAIDGEIPGVGDFNGDGKDDIVTFTRGTGGDVYVSLSDGTKFVQDSWKWHEFFAIGAEIPAPGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K2</accession>
    <name>A0A7W7T5K2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="PTHR38567"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20826" checksum="CFC25B87428F1157" modified="2021-06-02" version="1">MTPRYQVRADYDAHTIVVYQAYSPAIADAALRAGRFVAPFSFQRMTWIKPSFLWLMHRSNWARKPGQERVLAVRITREGWAEALSRAVPTTSDPAALAGAAVHVQWDPERSPRGAALNHYSIQVGIGRRLIRTFADEWVVGLTDLTPLVRKASALLRAGHAAKAQRLFPAERDYPMPSALRGVVAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S0</accession>
    <name>A0A7W7T5S0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="99"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="31355" checksum="F948526E3714AE4D" modified="2021-06-02" version="1">MTNGANPTVHKRQLGMALTALREKAGKSVDDVAALLECSSAKIRRVECGDVAVRASELKDVLDFFSATKTERRELEDLGREARKRAPHTPYGAVLPDFFRKFFSLEQIAAEILLYHAEIIPGQFQTPEYARALIEANPTHEPEEIDRLIQARQTRLSRITRDEDPQRQHVVLHEAAIRTMVGGPVVMKDQLLYLRKLASMSNVTIQVIPFSAGAHAATGLPFILLRFPDNVRNAVYLESLTSANSLDDPAHVAQYEMTFRHVVGAAFSPTKTSALLATVAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T673</accession>
    <name>A0A7W7T673_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quercetin dioxygenase-like cupin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="132"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="22088" checksum="6B594B59C8B91D54" modified="2021-06-02" version="1">MTGVRRAADPTGRPIGSAAGLVTVLDLDVDLVPDGESAVAVLSGSIVHSGLELEVGEGVYCPGRVSPAAPGTRVLVVGSPGPPGTPAVWTRGSGSAGDLVLAEGGGFVDMAVRWLVTDDTVGARGIVVATSVFRPGGHHRTHRHPNAAEFFLVLSGGGLHLAPDGPIRVGPGDLVFVPADEPHGFRTDPGTVTTTLYGYLGVGSLDQAGYAVDEGGDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J5</accession>
    <name>A0A7W7T6J5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="470" mass="48651" checksum="840F42DB140E6DE2" modified="2021-06-02" version="1">MFTAVVAILPLVTGFTTPSTVDDVAIDAAVARYRDVVAVPGVAVAVTRGTEIVRVAGYGHTATGEPVTDRTPMPFASLSKSVTAFAVQNLAREGRLGLDDPVRRHLPEFHPADPRADGITVRHLLAQTSGLTDATTPHPDVRTPRELAAGMGSATLASEPGAKWAYFNGNYQLAAAVVETVTGQSLADYLSRTVFGPLGMADSVAANTARDVPQFAQGHVKILGRPVAAAEPQDFGGGSGGVVGSARDLAAWLIAGNNAGRTPAGRQVADPADVEAAHTPSAGSYGFGWYVGTTGSGARLVDHGGDLVTSTAYQALLPESGYGVAVLANTGTQYSDAQRIGEMLIALLEGRSTAPPTDADLVVDAVILGLAATALALGVLGVRRARRWADRGKGRLRLVFFLLPAVLLGTAPQIISFLYRGRTVSWPQFVLLFPTTAILPAAATVAAVVTAAGRMVALRRHSVPATRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P1</accession>
    <name>A0A7W7T6P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding ferritin-like protein (Dps family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008316">
        <property type="entry name" value="UCP029876"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06304">
        <property type="entry name" value="DUF1048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="10731" checksum="2B303DD7652A2C98" modified="2021-06-02" version="1">MGIQDIIDGKRQWRAHMARVKALPPDYRIVYREMQGYLFKVGPVDLLDGPVLSGIVDFFEEGAAEGKGVLELVGDDVAAFCDGLIEASPAHRESVGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W2</accession>
    <name>A0A7W7T6W2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="770"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="838" mass="89142" checksum="5C82E0BF93376324" modified="2021-06-02" version="1">MTSPVLVGRTTEVEHLAGAVHAAPATVLVGGEAGVGKSRLVAEFLATHDVTALVGGCVAPPGLPYAPFVAALRGVDDAALAPLRDGVPFADDARPRLFEGVLILLARLAERRPVVLVVEDAHWLDPAGRALLDFLVRNQRSVPGSVFVVTYRSDERAEPVSLLAELARLPHVRRFEVERLSRDEVRAQVHAILGEEPEPAFVREVFDRSGGNPLFVEALVDVGGPPPDRLLLGRVDRLPADAVAIVRAASVAGNRVSHDVLSRVVDVSAMRSTVDSGVLSVDGDGYAFRHALIRDAVHRDLLPGERADLHARYAAVLPESAALAYHRLGAGDPAGAVTTAWRAARRARAALAFAEQSALLDLVLELWPHAAHLGVDRESVLESAGEAASRAGEHARGVELTTELLSRLDPRTEPVRVAAVLEQRARLRPLPDALDDHRAAVGLVSDDRISSYLLNSLAVRLLEAGLRDEARDAALRACAGDGPARAGALITLAALDLRTGDPDDQAKRLRTARDIASGLAAHRIVLRATHYESLLAAAHGSTAEAEAAARRGLRVAEEVGVARSSGAVHAIDLADVLIATGRWDEALRVVAEALDLVPPAARHADLLCRRGFVLLHRGDPDRAERCLDRARALGGDDPVLAAHLHRAAGRDDVAADVVRAATPVTWPLVAIAAEVGVGLPRPPAVCPVDRAWAATVDRDPAAADVWTALGRPFETLRALLDVVRSDPRGQADALRRAVDLADRLGAVDMRARLADLARRARVVLDGAGRARRSRLGLTPRETEILRLVADGLGNREIAARLFISTKTASVHVSNILGKLGVANRVAAAAAAHRLRLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X4</accession>
    <name>A0A7W7T6X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30811" checksum="5B4464C14F3FD332" modified="2021-06-02" version="1">MERRDLEIFLTLAEELHFGRTARRLHVSQARVSQTVKDLERRIGAPLFDRTSRRVELTPLGRRLRDDVGPAFQRITEGVDRAVRAARDTSLLRIGFQAPAVADLVPHVLGRYRRRNPGAEVRMREADFADPFGLLRHDEVDVLVTLFPVDEVDLVAGPVVFTEPLVLAVAGTHPFTRRPEVTLDDLARDVVFRAAFRMDATPAGHPVEHGRDVTTFQELLAAVADGEGVCPLGAHAAEYFARPGVAFLPVVDAPAVEWGLVWRRGGETAVVREIVGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y1</accession>
    <name>A0A7W7T6Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="30" mass="3375" checksum="83FB5F84EC7007E9" modified="2021-06-02" version="1">MPHPPRPGGEVMASYPWRVALEAVRRNGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T711</accession>
    <name>A0A7W7T711_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide 4</fullName>
            <ecNumber evidence="10">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_005098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Associates with subunits I, II and III to form cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017385">
        <property type="entry name" value="CtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="14712" checksum="82EF1BEBD7041E28" modified="2021-06-02" version="1">MKVEARIFDLVMGFSFLMAVVYGYWTWSATGVVEPVGAVALALTGGLALIVGTYFRFVARRIEVRPEDNAEAEVSDGAGELGFFSPGSYWPVALAAAAGTAGVALAFWHVWLLVIAVVLVLIAVGGLVFEYHTGPNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T726</accession>
    <name>A0A7W7T726_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="167"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="325"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="42063" checksum="00D91718059B79F1" modified="2021-06-02" version="1">MVDDHPAPLSPTTLRELQRASGELATSSVAEMERRLPWFRRMPADQRASVLLLIQNGVAGFVSWLHDPDQAIRLTADAFRSAPKDIARWVSLRQTVELVRIALELFERQLPGLAADDAERAVLTEGVLRYGREIAFSAATSYAAAAEARGAWDARLEALVVDGIVRGDAEESLLSRATALGWDPAEEATVLVGNPPSDDPPAVVFEVRSRAARLGRPVLLSVQGSRLVVVLGGETADGTAPARIAEAFGPGAVVAGPTVATLAEAHRSASDALSGLRAVVGWPAAPRPVRSLDLLPERALAGDPEAEWQLVDRVARPLEDAGGALLDTVDGFLEVGGVLEACARRLFVHPNTVRYRLRRATELTGLNPNDARDALVLRVALSVGRLARARGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T742</accession>
    <name>A0A7W7T742_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="24734" checksum="777BE1E3A2DA08D0" modified="2021-06-02" version="1">MTTRVALVTGSNRGIGLAIVRGLAEQGVHTALVARTEGAAARAAEPLRAEGLPVSAHQLDVTDVATIGRAVSDIVFEYGRLDILVNNAAVAIDRGFAASSLDQERVRATFEVNVFGAWRCVSAVVPVMKEQRYGRIVNLTTHMASLSTMKGNSPAYRVSKTAVNAMTKVLADELHEDGILVNAASPGQANTRMSYGAASQTPDEAARDLLWLATLPSDGPTGGLFHGRERLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T759</accession>
    <name>A0A7W7T759_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8842" checksum="C58AEDA5375DF7CE" modified="2021-06-02" version="1">MSETVYNRIAMLRAERGVSRRQLSEALGIHYQTVGYLERGEYSPSLFLALRIARYFEVAVEVVFSTEPFPRLGERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A6</accession>
    <name>A0A7W7T7A6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase beta subunit</fullName>
            <ecNumber evidence="2">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="543" mass="60882" checksum="0E8B0EBC1CDDCBF1" modified="2021-06-02" version="1">MRVMAQLAMVMNLDKCIGCHTCSVTCKQAWTNRSGVEYVWFNNVETRPGLGYPRTYEDQERWRGGWTLGKRGKLTLRGGGRLRRLLSIFSNPKLPALDDYYEPWTYDYENLTNAPLQEHTPVARPRSLISGEPTKITWSANWDDNLGGPHGQRDPMLSERVRLEFERTFMFYLPRICEHCLNPSCAASCPSGAIYKRSEDGIVLVDQDRCHGWRMCVSGCPYKKVYFNHRTGKAEKCTFCFPRVEVGMPTVCAETCVGRLRYIGLLLYDADRVLEAASTPDEKDLYEAQRGVFLDPSDPAVAREAERAGIPTDWIEAARRSPVYALIEKYRVALPLHPEYRTMPMVWYIPPLSPVVDVVRDTGHDAEDHGNLFGAIEALRIPVDFLANLFTAGDPKPVESVLRKLAAMRSYMRDINLGDAPRESVAASVGMTGVEVHDMYRLLALAKYDERYVIPAAHAEQAHGLEELGCSLDYEGGPGMDGPFGESSGGASPIAVENFHLLRERQTGDTVAAPVDKSRRVNLLNWDGKGRPEGLFPPREGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7C0</accession>
    <name>A0A7W7T7C0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-dihydroxybenzoate-AMP ligase</fullName>
            <ecNumber evidence="3">2.7.7.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.58" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008668">
        <property type="term" value="F:(2,3-dihydroxybenzoyl)adenylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="443"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="545" mass="59066" checksum="E8DACAD968CC8ED8" modified="2021-06-02" version="1">MLDGCTTWPADLAARYVRDGLWRGQDLGGLPRRWAERSGGKTALVHGETRLSYRELADRIDRTAAGFADRGIAPGDRVVVQLPNTPDFVIVVFALFRVGAKPVFSLASHRANEIRHLLSLSGAVAYVVPGVHRGFDHDALAALMLAEVPTLRQVFTTGDAGFTTLSEVDAEPQAPRSNDPSDVAFFLLSGGTTALPKLIPRTHDDYAYQTRAVAEVCGVTADDVYLAALPVEFNFTWGCPGVIGTFGVGGTVVLAADPGAEDSFRLVERERVTFTSLVPTVAHLWLEEREWSTADLSSLRFVQIGGARLQPGLAARIEPELGARLQQVFGMAEGLLSMTRADDDLDAVVHTQGHPISPADEIRIVDENDREVPAGVAGELLTRGPYTLRGYYRADEHNKRAFTADGFYRSGDLASLTAEGRLVIEGRLKDVVIRGGDKVSAGEVEGHLLAHPEVARAAVVPVPDEFLGERIYAFLVHRDDKPALPELKRALHERGLAEFKLPDRVEYVEAFPLTPLGKVDKKVLAAAAADPGLARDWAPVEPKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G2</accession>
    <name>A0A7W7T7G2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methylcytosine-specific restriction endonuclease McrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23457" checksum="A4D22C90F1A49B9D" modified="2021-06-02" version="1">MPDRQPTPIGALANAGLAPMVPSGQKQHGVHAVVDGGGPGQALVLPWGRRKVLLLNATFEPLTALPLRRAVVLVVCGKAEVVHGDPDGAVVHSSTSQVLVPSVIRLSNYVRVPYRGRVPLTRAGLMHRDRYRCAYCGGRAETIDHVIPRSRGGPHTWTNCVACCARCNHRKADRLLSELGWRLRVVPSAPRGPHWRLLAGVAEADPQWLPYLGEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I4</accession>
    <name>A0A7W7T7I4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031456539" evidence="2">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20091" checksum="0B1F2E243B3E2F69" modified="2021-06-02" version="1">MNRIRMWLAVALAASALTGCAYSINGTPVPMAGGEAATSASTTSSSSGGAPKIAKQRTVAGVDPCKLLTADDLKPIGKLTKDPARKDDVIQESCQYVVDDGSAGGRSVVTALYQQYEQVRARQGKGHEEVVDGHSAWVYCDAGSGDMACTATIAVNKNRSVLVAMTTKTGVADQVLATMQPLMKAVLSRMPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y8</accession>
    <name>A0A7W7T7Y8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="11" type="ORF">F4559_005603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="571" mass="61245" checksum="EE1E192D6A9C5AD3" modified="2021-06-02" version="1">MPSLRLALAQVNACVGDLSGNADLVVDWTRKAVESGAHLVVFPEMALTGYPVEDLALRESFAEASRAALTALATRLADAGLGGIAVFVGYLDRDERGVRNAAAVLHEGAVVARQYKHHLPNYGVFDERRYFVRGDALEIVRLHGVDVGMVICEDLWQDGGPIAALGEAGVDLVVSPNASPYERKKDDARLPLVARRAAEAGAPLAYVNLVGGQDELVFDGDTMVVTAAGVPVTRAPQFVEHLTVLDLDLPGGAARASGEVGGFTVTRKTISDAPVPAYEHLPVPPTAEPLSDEAEVWHALVTGLRDYVHKNGFRSVVLGLSGGIDSAVVASLAVDALGAGHVYGVSMPSVYSSDHSKSDAEDMALRTGLHYEVQPIAAMVEVFVDQLGLTGLAEENVQARCRGVTLMGLSNQHGHLVLATGNKTELAVGYSTIYGDAVGGFAPIKDVLKTLVWDLARWRNAEAEKLGEQPPIPENSISKPPSAELRPGQVDTDSLPDYELLDAVLDDYVEGDKGYQDLIAAGFHHDLIDRVLRMVDKAEYKRRQYPPGTKISFKAFGRDRRLPITNGWREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T865</accession>
    <name>A0A7W7T865_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="18158" checksum="668F57CE5CC5E37C" modified="2021-06-02" version="1">MQIDTAEYQRVLGDELRGLRKQRGWTRKELNRRLQSDISLQTLATYELGTRQCSVVRLAEICLALGVPAHQVLARVHERVFGDAPTGHLAVDLTAVIADDRPQLLPLRRWAQGRLTQLPPHRTAEVHLDQPALEYMAQLCGMETADLIKTLRDLDGRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E8</accession>
    <name>A0A7W7T8E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein-anchoring transpeptidase ErfK/SrfK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="110" mass="12165" checksum="982BBC5F843889A1" modified="2021-06-02" version="1">MEGACIRLSTRESWLIEGGVVVLGPVPITSGRPGYETPVGRFPVLYKVKDEWSIPYDAPMPYSVYFTNYGIAFHEGSLTDLSHGCIHLSPEAARRYFDSLRTGDVVQVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E9</accession>
    <name>A0A7W7T8E9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6636" checksum="34A2DB67E9701CC9" modified="2021-06-02" version="1">MIGHHETAVWRKSSRSGNSGGQCVELRSGLTAVRDSKNLDGPVLEIGPEGLAAFLAAAKADRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G3</accession>
    <name>A0A7W7T8G3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na+/melibiose symporter-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="18137" checksum="94ADF8C6093A11D5" modified="2021-06-02" version="1">MRTDDEVYRVDAVWLGPPKATFPWRARYVAWGVGIAVFLLVMTVERQMGIGFGFFSTAWAFVATLILTRFICARISHERPLSAVLTMWGRELTAPREVTSGRGGASSAARLRVTAERPRRQPKQQRKKGAKRAASATRAQTPRQSDRRKKEVRGVRTPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I0</accession>
    <name>A0A7W7T8I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound lytic murein transglycosylase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030892371" evidence="1">
        <location>
            <begin position="33"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="2">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26365" checksum="7009097E676E0CDD" modified="2021-06-02" version="1">MVPPPSSSRPPWVRVALVVAALVLLAAGGAYALDALERRPSSGFAIPALDVEPGAAAPATSSGESTTEWTAAVADRTEIPARALRAYVDADRKTRATSPDCRISWATLAGIGRVESHHGTLGGLALGEDGRPSSPIVGIPLDGSPGVRAIEDSDRGVLDGDGRWDRAVGPMQFIPTTWAIYAVRASGDGRPPDPQNIDDAALAAANYLCAAGKDLSTGAGWWQAVMTYNNSVEYGRKVFSGADAYAKAASAPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8L5</accession>
    <name>A0A7W7T8L5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD DNase family protein</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30412" checksum="86CF915379F474D7" modified="2021-06-02" version="1">MTKRHGERPPVPEALPVPAVDSHTHLDACGAKNADDVRALLDRAAAAGVDRVVTVADDLASARWAAEAATWDDRVFAAVALHPTRTSSFGDAERAELTALARRPRVVAIGETGLDYYWDYSSTADQHAAFRWHIGLSKLVDKPLMIHDREAHDDILKILDEEGAPSTVVFHCFSGDLAFARACVERGFVLSFAGTVTFRNAHALREAAKRTPADHVLVETDAPFLTPHPFRGRPNEPYAANYTLRDLATLREVDLGELAATVTRNAERVFRLGDVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Q0</accession>
    <name>A0A7W7T8Q0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">OmpR/PhoB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="282"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="48750" checksum="4159CE6567BE5722" modified="2021-06-02" version="1">MPPQPRPVIAESWRRSLAARVDPDRPEAPVVLAPDEVAHVRHAHPLAAVLPVLRETLAEAITQSAHVMIVTDADGRVLWCEGASAMRDLAERARLTEGARWSEDVVGTNAMGTALALGRPVTVHSAEHLVRAYHGWTCTASPVRDPDGHVLGAVDVSGPLTSLHPAMAALVSASARLAEHGLRLRRDAADERLRAANLHHLLSLRGEPGALLGPTGRVLAAEPHGLFGDRLDPSGPVVTRDGREAVVERLAEGYLVRLPRPARTRPVLTLRLLGDPEGDLDGYPLVLSPRHADVLAALCLRPHGATAERLALLLYGERGNPTTVRAELHRLRAQLGGVLSARPYRLHARVRADFLTVRDAVRAGDVDRVAGVYRAPLLPASEAPVVVAEREDLAAAVRRTVLDRGGAEAVWALAATTEDDVELLDRLVRVLDRDDPRRDVVAARLRRALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S8</accession>
    <name>A0A7W7T8S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-beta hydrolase superfamily lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26993" checksum="A53F3835800018AA" modified="2021-06-02" version="1">MIESNVPGHAGELSVRTWPNLDATWLAVLVHGLGEHGGRYTHVAEELVAHGALVVAPDLVGHGRSEGRRAVLADFAGIVADVGAAISSAAADLPTVLFGHSFGGLAAVRHAQDHDVAALVLSAPLLGAWDGLDRPDDAVDPDLLSRDPEVGRRYAADPLVWHGPLPDVTLGTIEHALDEVNFGPALEHLPALWLHGADDRIVPVSDTRTGTDRIRGLRFEERIYPGARHEVLNETNRDEVLADLVSFVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9S8</accession>
    <name>A0A7W7T9S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22774" checksum="30EFB78D527954A5" modified="2021-06-02" version="1">MPVRVLLVDDHEVVRRGLRELLDDEDDITVVAEAGGVDEAVVRAEATRPDVAVVDVRLPDGTGIDLCGRLRPTGVHCLVLTAFDDEDALVAAIMAGASGYLLKQVRGQDLVVAVREVAAGRSLLDPRTTARVLERMRRVPEVDVLDALTEQERRVLHLIGEGMTNRQIAERLFLAEKTVKNHVTSVLSKLGMERRTQAAAFVARRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T0</accession>
    <name>A0A7W7T9T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative small integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018681">
        <property type="entry name" value="DUF2165_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09933">
        <property type="entry name" value="DUF2165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030847187" evidence="2">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17405" checksum="4D0F7795BA3F4C43" modified="2021-06-02" version="1">MRLLGSRRTAVAVLTAVSAVYMVLVVLGNVTDYGTNRAFVEHVLAMDTTFRSPDLMWRAITSPAAVTVAYVAIIVWEAVDALVFLGALVAWIRRDERARALASLGWVMQVLLFGLGFLAIGGEWFAMWQSSTWNGVTAATRNVVIALLGLVLAHLPDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA07</accession>
    <name>A0A7W7TA07_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13950" checksum="68A78420718A5AD5" modified="2021-06-02" version="1">MNDTGLEVRAWWRRLAGRSCAAVINAVLGYVGVLPLLLLVDLLSNTVGVGLGWAEPDTKFGSDGVLFSVAFDVVVLVFFVLLFFTVNLWTARLLKVSGPASWVSAVLITVAPTVVATVAPDLWTAVRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA52</accession>
    <name>A0A7W7TA52_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035169">
        <property type="entry name" value="DUF5318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17249">
        <property type="entry name" value="DUF5318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="15092" checksum="DA63A442F6148055" modified="2021-06-02" version="1">MSTQRQVVDYALQRRALLAEVYAGRVGTMEVCDASPYLVRAAKFHGEPSDVTCPVCRREPLTHVSWVYGDELKHAAGSARTADELARMANLFEEFTVYVVEVCRTCSWNHLVQSYVLGKRGVDSQKPRRRTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA71</accession>
    <name>A0A7W7TA71_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="28"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="8749" checksum="F037B0C03EB60D2E" modified="2021-06-02" version="1">MSAHDTGWFRSSHSSAGSNTCVEVRFTDWSKSSHSSGGSNTCVEVRFAETAVGIRDSKNPTGPRLEVTGRAWAAFVGQLVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAL9</accession>
    <name>A0A7W7TAL9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="273" mass="30136" checksum="8B68F8F376AB5D8E" modified="2021-06-02" version="1">MDGVERPAWAPGDIDLGRPSIARVYDYWLGGAHNFAVDRMVADKVLADVPVLKSVILNHRAFLRRAVRFLLDQGIRQFLDLGSGIPTVGNVHEIAQAVDPGARVVYVDIDPVAVAHSRAILTGNPLVNVLQTDVRDAATVLKSPEVLDLLDFDRPIGLLMVALLHFVSDEEDPRGIVASYRDALPDGSYLALSHAGYEPGEWNPAWNEARNTYNRGVSEMTYRPRQEVEALMTGLDLVEPGVARLPLWRPDSPDDVDEGAHRFMSFGVVGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBS3</accession>
    <name>A0A7W7TBS3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="5">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppa</name>
        <name evidence="6" type="ORF">F4559_006254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="19130" checksum="127E7B8C8C42F5B8" modified="2021-06-02" version="1">MEFDVTIEIPKGVRNKYEMDHKTGRIRLDRTLFTATQYPADYGFVDDTLGEDGDPLDALVLVQEPTFPGCLIRARAIGMFRMTDEKGGDDKLLCVPAEDPRSEHLRDIHHLSEFYRLEIQHFFEVYKDLEPGKSVEGATWVGRTEAEAEIVRSYQRLKDAIANGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI9</accession>
    <name>A0A7W7WTI9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8881" checksum="0A2E71F8FB993FCD" modified="2021-06-02" version="1">MTIEAHWPLYPELRTADSMRIERPEDVDLLLTRLADKDSGSATLVHRGRLTVIDEGTGGQLVDHDVLTAVHDGYGYLSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM1</accession>
    <name>A0A7W7WTM1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">2-oxoglutarate decarboxylase</fullName>
            <ecNumber evidence="16">4.1.1.71</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_000618</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.71" evidence="16"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008683">
        <property type="term" value="F:2-oxoglutarate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="15">
        <location>
            <begin position="887"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="797"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4963259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1227" mass="134912" checksum="948323564908AE88" modified="2021-06-02" version="1">MSSSSPASQFGPNEWLVEEMYEQFLADPSSVDPAWHDFFADYKSTQRSGNGATAAQAESGTAPAAPTATATRPAPEKPAARPAPKTEAKPAPQTKPAAKPAPASAAKAAPVKEQAGQEQKQLRGAAAAIAKNMELSLTVPTATSVRAVPAKLLADNRIVINNHLKRTRGGKVSFTHLIGYAVVRALQSFPNLNRHYAEIDGKPFAITPEHVNFGLAIDLPGKDGSRTLVVASVKGCENMTFTQFWQAYEDLIRKARGGSLTTEDFSGTTISLTNPGTIGTNHSVPRLQAGQGAIIGVGAMEYPAHFQGTSEQALTDMGVSKIITLTSTYDHRIIQGAESGEFLKRIHQLLLGEDGFYDDVFTSLRLPYEPIRWVADIPEGAVDKTARVIELIDAFRTRGHLMADTDPLNYRQRSHSDLDVLSHGLTLWDLDREFPVGGFGGKERMRLRDILGVLRNSYCRTVGVEYMHILDPEERLWIQERVEVPHEKPPATVQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGGETVIPLLDAVLDKAAEHELDEVVIGMPHRGRLNVLANIVGKPISQIFREFEGNLDPGQAHGSGDVKYHLGAEGKYFRMFGDGETKVSLTANPSHLEAVDPVLEGIVRAKQDQLDKGGEGFTVLPVALHGDAAFAGQGVVAETLNLALVRGYRTGGTVHVVVNNQVGFTTAPENSRSSKYSTDVAKMIGAPVFHVNGDDPEACYWVAKLAVDYRQKFNKDVVIDMVCYRRRGHNEGDDPSMTQPAMYDVIDTKRSVRKTYTEALIGRGDISVEEAEKALQDFSSQLEHVFNEVRELEKHPIKTSPSIEAEQQIPAKLPTGIERSVIEHIADSHVDLPEGFTPHPRVKPVLERRAKMAREGGIDWAFAELLAFGSLVIDGRTVRLAGQDSRRGTFVQRHATLVDRKKGDEYTPLQNLAEDQGKFMVYDSVLSEFAALGFEYGYSVANPDALVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQVSDVVLLLPHGHEGQGPDHTSGRIERFLQLCAEGSMTIAVPSTPANYFHLLRRHALDGVNRPLVVFTPKSMLRLKAAVSPVEDFTEERFKSVIDDPTITSPDAVTKVLLCSGKIYYELVAEQEKRGATDTAVVRVEQLYPVPVRKLTEALERYPNAADVRWVQEEPANQGAWPFYGLNLPDLLPSRYSLKRISRRPMAAPSAGSSKVHEVEQREIITKAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTQ0</accession>
    <name>A0A7W7WTQ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031257379" evidence="2">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="16650" checksum="F85B9FBBBDA959EA" modified="2021-06-02" version="1">MRWYQRIVLVGAVLSAAACGTSEPTAGSPAGGTTAASVDAEPLSDADREAAPAVAQRFADAANAGDSAGVAATFAEDARFDSVGRIYPSRADIMDRFLDPEVIRAGGRYEVTGTRWNGSRYVVDYEFTTRGGGSETFYYEFLVRDGLIQDVIGRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTW3</accession>
    <name>A0A7W7WTW3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="30512" checksum="7AC68DCD58CAC08A" modified="2021-06-02" version="1">MMAVVDTASAVRARDLGKRYRAKWALRECTFDLPKGRVAALVGANGAGKTTLMSVLSDLLVADEGSALVDGRVAFVAQEKPVYRHFSAADMLRLGAHLNTVWDQERAERWLERFEIPLDKACGKLSGGQQAQVAFALAIGSRPAVLMLDEPLANLDPLARREVTAELLSEVDETGMTVLLSTHVVSELGGVADYLLLLAHGRLLAGGDVDDLLTGHATFVGPRSDAPPVPGTVVEARHNGGQSTFLMSLPEDGPRPRAGAGWVEHPVNLEEYVLAHLGANRKGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX1</accession>
    <name>A0A7W7WTX1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="10" type="ORF">F4559_000945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="12736" checksum="BE383726634DCBD0" modified="2021-06-02" version="1">MAEMTVQLVAVERRLWSGRATLVVAQTTEGEIGILPGHEPVLGQLTEGGVVRIKTTDGHTVTAAVHGGFLSVTGTEVSILAEDAALSGEIDVEAAKQALSADLDEVERVRAAARLRAAVGHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU32</accession>
    <name>A0A7W7WU32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="578" mass="61443" checksum="0A407C0EA11190D5" modified="2021-06-02" version="1">MRKALLIATDTYDDPAYDALRAPRHDAVALADVLTAPTIGAFTASVLVNRSAHDLRLALDEFFGEADREDVLLLYLSGHGIKDMRGRLHFVASDTRADRLAASGVSAEFVRDLIDSGRARKVLVWLDCCYGGAFPPGAVPKAAGGVDVLAQLDDGRGCAVMTASTHVQWAYEPSGSVTGTPTRSIFTEAIVTGLRTGAADLDQDGLITSRELYEYVYEQVRSVNPAQTPTGNDQVSGRLLVAYAGRAPVAPVFVRPAPSLSFESWTWTAKLDVTGVPVFSPDGRWFVCGRWVWDTGDWRRVAAFEVISSPAFSPDGRVLGVPTSHGVELVDVGSWRAAEILPYSAKPSGDLSFSTPDKLLAPDATLWWRESGRWQESNALQYVPESTTFAGELTLHRLASGTEVWSGDDLLGQLVEPVVAGGGLVAGSGQVFDSRRQPLISFTGRAAALSWDTLAISEPDRVRLLDVASGRELHLLARPGGHGPVAISPDGRLIAASNASGTRLWARSTADLHPLPFSPTSPASAAESRSIAPWVVGPLAAGVGALLGVTFSLPLVVTIAVAVALGLVTFFLLLAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL5</accession>
    <name>A0A7W7WUL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg-chelatase subunit ChlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="405"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="593" mass="62682" checksum="F35FB193C04D3BEF" modified="2021-06-02" version="1">MSRHRALRTKVRRGIAKWPVTVLAAVVLVFLGYLGYTWIADLVERRAAVEAGDCGEGEAVLRVSAAPSIGEAVRTAAEAWAKQRPVVYDHCIRVEVQSIESTDVLQALTQNWDEAELGSKPHAWITDSTLWANRLAAQNRSLLAAAPESIAASPVVLALPQDAATAVQAGAGFRWTDLPAVATDPAGWGRFGKPEWGGVRVAMPDPATNAATAMAIQSALAGASPDGKGPVTTRMLELDPVRTTLGKLVTAKPARTPASTWQALTLLAADQAVNSAGFSAVPVFEVDLYRYNTGKDGGTAPAQPLYGVAAGGPAPVADFPFVPLAGSWVGEAQLRAAQAFRQFLTEPDQQRILAAAGLRVPATNDRPKPAPGIRWASMTDRLTPADETATQQISATWATADGGQSVTVLVDTSESMANAGGEGRPRLDWVKQALSGQVGRSLSGSMGLWEFSRSLDGDRPYRRLVPIGPVATQRAALLEGIKSLEPRRGSQLYTSVLALYKNVVDNHQEGKRNRIVVLTDGPSDGGLSFSDFKNQLAAAKQQGREVSVSIVAIGSDPDRRSLQEIARSTGGTLSVVEDGRGVDAALNELLGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY4</accession>
    <name>A0A7W7WUY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="991" mass="106210" checksum="7033148C3DF1E955" modified="2021-06-02" version="1">MLRRDGAEARDLAHDEFGVLGPLVVRRGGRVVTITAAKHRVVLATLLLCANRSVSAAELIRRVWGGVPPDRAGQTLPVYVMRLRRVLGDPAVIHTTSTGYRIDVPDGALDLDRFGVSADAGRAAVAGGDAAGAVVHYEQALALWRGPVLADVPSESLHETEVPALAERRLRVLSELMDVKLRLDRCDEVIADLRRLTARHPLRERFWSQLMVALYRVDRQADALDAYRQASTALARELGVDPSEALRSVHHAILTGDPALHRPAATEWTPVSQLPAPVGNFVGREEELERVTGLLSGSTATVVVCGSPGVGKTAFAISVGHAVRDRYPDGQLYVNLRGHSTSPPLTTSAVLARFLRAMGVRADRIPVGEDALVRGYRNRLRGRRVLIMLDNAASTDQVLPLLPGEAGCSVLVTSRNELCSGTCQTVVRLDVLRGDEAWRLLARSLGPNVAMSEFEAIGELARLCGYLPLALRIALGNLVGSSHADISSYVDELRGGDRLAALAVDNDDSAAVRRAFDLSYAALSPDAARLFRLAGLVPGPDFSVAGAAALIGGPESTTRRLLGDLAAAHLVQRVGADRFAMHDLLQDYAADRSRAAGDDGTAARRRLFDWYLGTAVAVGDVLYPELRPGPAGTPTLGAARARAWLEAERPSVLAATEYCARFGPRRLAWQLIDAVSGYFGSHGHHVEFLHAVDAALGAARRDREPAAQTAMLVWLAAEHRNLGNLRVAQRYLREAEPTGDTLWLHAGLDGVVNLELGDFAAATTSFTRMLDLGAHARIGGLAGLGAVALMRGDVTRAEESLLDGLERARVAEGVNLEATCASLLARCRLETGAYESAVELLRFALAAWYRTGARHARAEGLAYLATALCLDGAHAEALRTAQRGLALVQELGGSPRIESEVHNALGLVLRHQGEPGRAAAAHRRALELATDCDYRYGVTRTHVLIAKALRDDGLVGDAVRHARIGRDLAFRSGFGTFGRTADDLLSALSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV09</accession>
    <name>A0A7W7WV09_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="25787" checksum="6F6AA27FE69BDF81" modified="2021-06-02" version="1">MLVLLPPSETKSIGGRGVPLELDALSFPDLNPVRAKLVDAVVELAADPDTARSVLGLSQRQADEVARNAALRTSPTTPALSRYTGVLYDALDYAGLTRAGKSKAVARLAVASALFGVVRGGDPIPAYRLSGGSVLPAVGPLGALWRPVLEPALAGVDDFVVDLRSGPYSGLARIPGAVVVKVVTEDDSGRRQAVSHFNKAHKGFLARALVESRAEPDSVAKLIRVAGGVGMRLERTGADAVDLVVSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV93</accession>
    <name>A0A7W7WV93_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14176" checksum="3C0347A3B976D44F" modified="2021-06-02" version="1">MPNLRISEAAALLGVSDDTVRRWIDQGRLEAVRGDNGRLAVDGRELAAFTERAAEVPEPGVTIAASARNRMRGIVTRVVKDTVMAQVELRAGPFRVVSLMSRDAADELNLEVGSVAVASIKSTHVVVEIPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF4</accession>
    <name>A0A7W7WVF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (DUF305 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031317995" evidence="1">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="47"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20700" checksum="DDEAFC8ADE40D7FD" modified="2021-06-02" version="1">MKRLVALVAGLSLLLVAGCSSPSDGLVTPTGPAPSTIAETAEHNDTDVMFLQMAIAHHKQGLEIVKLAKDHAVRSDVKTLAAAIEVTQLSEIDSMTKWLGDWGKPESSGTDMQLHADHGGDHSTRPEDIAEIAALPSGEFEKGFLNLLIAHQHNAVAIAKFEREGGSNPQSKGLADRIFESRSAQIAQMLGYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU6</accession>
    <name>A0A7W7WVU6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="42535" checksum="2058B05440897823" modified="2021-06-02" version="1">MDLVETFRRRRAVEGPVFWLDSDLVVLDPRVAAAVNRANFADFTLNPSVGDQLRGRRGALVDWRDVRAAWLPRIRELTEPEHLRALAERMDRILSSRLDTPLDLVWLSYETAVRSLVPLVIADLDAKDNAILARDLIAKVATLLDRPAPLSIVAQARAGAMVRRRIKRRAAGPGRADLLDPIARELLGVLGIGRAVEATTAMLTAITGPPGSAAASVLFELSRRPEWQERLGDELAAATDLCTAPQSRAPVTTRFVKEVLRMWSPPLLLNRRVRTAVSVEGVELRPGQQYVTCPYLVHHDETRLPDHATFDPDRWLADPTFDYVPFGWAPTTCLGAGIGIAQLILWCRLLTTRYRVTTNRPSRMTMLASPTPHDFRGTVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW13</accession>
    <name>A0A7W7WW13_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="499" mass="52965" checksum="EEEA06553A617DD9" modified="2021-06-02" version="1">MVDRTVAGRYRLTEKLGAGGMGVVWRAEDTRLRRIVAVKELLARNGFDEESTRRAVREARIAARLQHSNVIALYDVVEDEGHPWLVMEYLPAKSLSAVISERGTLPADEVRRIAVQLAEGLAAAHKAGVVHRDVKPGNVLVTEFGTVKVTDFGTSRAADEATVTSSGLLVGTPAYLAPEVAQGSPADFPADVFGLGATLYAALEGSPPFGEDTNAIALLHRAAAGTFPAPENAGALEPVLLRLLDADPGARPTMAEAARMLQEISVEPVTVLASPTPVEAEPTRVVPPAKATTELPEPEPESEPEPEPVVEEEDPQRKRFALVAVVLIMVVVGTVAFLITRSRGKDDKAADTTTTTTGQTVATSAPPTSDAGQPPPQGETPVTSTTSEAPPPTTVPPAAVTPDKALVDYYALLPGNIDAAFPTLTESFRNGRGVDYDYYRNFWAGYSAVSLSNVQVVGENQVSATVNYTDLSGAQKSENNLFTLVKSGDKWLIDNQVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW66</accession>
    <name>A0A7W7WW66_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6382" checksum="5C862DC4260D905F" modified="2021-06-02" version="1">MSALHTVVVNHEEQYSVWPADLPVPAGWREAGFRGTRAEALAHIETVWTDLRPASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB0</accession>
    <name>A0A7W7WWB0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="577" mass="62094" checksum="08757DD621ECB6F0" modified="2021-06-02" version="1">MNPDQNAVASGSGIVVQAGRDVYLGGGPERKAGPPGVALADALVSGAEAYEVHPALTVGSTPTEELTAYVRRTFDDRLAGIAASARDGACRMAVLVGGSSSGKTRACWESLHSFGAGWRLWHPLDGEQLVEGLKAGIAPRTVVWLNELQRFLVREEEPRWRAAAIALRGLVAAPVEGVLILATIWDEHDRWQALTGPPPPGGPDHYAQARELLRRADVIPVAATLDAGERARAEEAAQSDARWAVALVEDRPIPFLAGARYLVDRYTTGSPAARAVLEAAADARRMGMPTVLSLAFLEQAARDYLDDADHDRLPPGVGWVRHVIETDVRVGGFGVPGPLRPSGSGYRLADYLENHLGRRRVAVQPRDSLWSATVDVVPDTAVLSTLAEAAMRRGRFGPATRLSARALDLGDLGSARMLVTLLENAGEHAEALSIAERAGLDRAVERLRRKIDDGDTGFDLSLWWVEAEEGTRENGEELVWDDTLDAFSARLDDAGDDLAAAERIAVEAAAAGYLWPFFHLAVGREEVGDVLGAERLWRQSIAAGNVFRVLNLAELRGDAERTWRFAITADGLPADGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF0</accession>
    <name>A0A7W7WWF0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANAPC5" evidence="1">
        <location>
            <begin position="531"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="ANAPC5" evidence="1">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="ANAPC5" evidence="1">
        <location>
            <begin position="795"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1069" mass="116405" checksum="DD1A7573F62106CF" modified="2021-06-02" version="1">MTERPMSNSVENAITGYASHVVQAGKIYGDINFHHPAPPPDPPYHPLPSHPPEVWLLQPHFGVVPYLGREDLLTTLQTWCETDHPFAIAHITGEGGSGKSRLAAEFCTRMTAWASGRAGPETLAVLAPTTDTVLTIDYPEQGTAVLGKALERLATRPDGPRIRVVLLSRATHWWPELDRAGHRTASLFTTLHLDLAEHTLSPAERHTHAKAAVDAFSHHLNLKPVPPPDVTDDDYANPLLVHVAALLALHGHRTANPVRENVLAHIVTRERNRWTRLLPAHHLADLHETHALRAVLLTLLTAPSAAEAADRLAALPEFAGEAQRERRSRIAYWLADLYPGDPLMTSFGPDLLIEELLDTPVLDEVVTTAHTHSPSGRVRLLNTLRLAAERRPTVRAALHKYLISSIDVLAHQALDAPNGLLTDAVDSALTLCAERDDPHLALACVELRKALPLDHERDARLLCTITQALLPLSRRLAEKDPKDGLVALRLSLSLLSHNCLQAGRFEDALAANTECVDVSRRLVENDDGHRTSLAFDLGNLAVGNVHVGRLDDALAAAVESVAVAREIPEDENTAALALIKLSGIHAELGEYDVALTANTESLAVLRRLVASGEKYYLPYLVHALTNRGAILSGLGSHADAATTIMEAIDLRGTLGRQPGPELPEPHYDLHNLSHVLTKQGRHEDALAAIRKAVEAARDLAAVNPARHRAMLVRNLEQLSRILLRLERADEATDAQLEAVDVARQSSRPNLAVTLAGLVAVLLTQNRHADALPVCLEAVTHLRQVTSSRPDLLVVLASTLVDLNTIMNRLGRSGEALAAAREAVDTTRRTDPFAHPAPADALVTLAHQYARSGRWRDAAACISDAAVLLRITNRIDLLADVMADLAEFHTRLGHDGPAAAAALQSVRITHGTTPTDHALKLLGEIQHAVGRHATALRTLRKAAELFDDRPPELAQILHSLADLRARQGRYADAIVDCRRGNELYELLATRDESRYLDQFAHSSSKLRALLIRVGRVEEALPVARRHVKIAQRLAAGNPRFKEVAAEARSGLAEVLSHLGRFAAARRAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG3</accession>
    <name>A0A7W7WWG3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="219"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="37336" checksum="C758C48A51501962" modified="2021-06-02" version="1">MPGDGSATATMAGPEEFAKLADPFRAELLAHCKRMLGSVHDAEDQVQETFLRAWRSYGDFEGRSSLRTWLYRIATNVCLNALESRRRLPVPFGFPGAEGDQDRDAGWPEGGPQAASRVARETAAEAAEQVDPAMIVATREDRRRALLVMWERLSPRQRAVLILRDVLSWQANEIADLLGTSGTAVHSMLRRARAQLAQAPTVTEVDEPDDVTLRGFLAEYAAAFETGDINALVYLLTEDAVCRRQPSDTVLSGRAAIVRFLAHCPAVGQCRMVPISVNGRPGFGVYRAGEDGVYRSYTIDVLTISTSGFERIEVIEDRSLFGTFGLPQVLPAEANVEANPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL3</accession>
    <name>A0A7W7WWL3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="30165" checksum="52D83D140E15FC5C" modified="2021-06-02" version="1">MRTDDTGDTWRRTTLPTLGEADRFRVYFTDHGTGFVADGSHVHVTRDNGHTWHRTTFEATGTARAIAFTTLDHATYLVAATTTTTALYRLPARSTRWSAVPGVAASGVPDGDVTVHEGRVHTTLAGRYWSGARDTWTESTPPCPANAATDLSAAPGTPLFALCGDDPGMGRMHKLLRRHTNTGFVDVSEAPREGITQSFAAVPGPEGRVALTSVGLGATFVHLATTDGTTWTSPLIVEEPPLTDLVFTDDHHGYTLRPALPDNLFHTTDGGTTWHPLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP4</accession>
    <name>A0A7W7WWP4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="31349" checksum="4898D4F788A5D993" modified="2021-06-02" version="1">MVEQTRSGRRVGTTLSDALDARVVELRHLDDVVGSQDLLPAVRKELAEAEALVRNSSYPDIIGSRLLTATGELAQLAGWVASDAGLHAEAQRVYLSGVSAAEAANDFVLGGQLFSSLSYQMANVGNAEDALLLARTATHGARDATPVVRALLLERVAWASARVGDREATRRTLDEVDDAYERRTDGLPEPEWVYWLNRAEIDVMAGRCMIELGAPDKAEPLLSAAIATYPVEQAREVALYLTWLAEAYARSGQMDAAGATLSDARGFAAAMPSARTSLRLSTVATLIGDYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX57</accession>
    <name>A0A7W7WX57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein YfcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="6724" checksum="C46C4370044115AF" modified="2021-06-02" version="1">MSAIAMLAGGILSVLLRNLVDGRRTDTPHWRSTGALVLGSLTGAAVGGSIADRCRATMKRKEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK3</accession>
    <name>A0A7W7WXK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="6997" checksum="474DC6303B92F55C" modified="2021-06-02" version="1">MTKPSHTPSNQPDPAPFFTVHTALILLAAAFIGAVVGGLTFLSGGPVAGAVLAGLIGFGTSVPVLRSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM4</accession>
    <name>A0A7W7WXM4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RND superfamily putative drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="76"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="458"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="715" mass="76169" checksum="342ABC9D369417F2" modified="2021-06-02" version="1">MLSRIGRFCYQRRVWVFGVWLLVMAVGGVAFSPLFNSLALNKPSQGMESNVARQVLTTEGDYYDKLIAVVDGGDLRSVPAQDAMGRAVDEVRGITGIKEVADPVASPDGSAAQITVRFGKLPKTEKKRVLTEASDRLHKVADDVPGSKVVIGGDEPQAQETNATSGADTLRAELSTLPIILIALVVVFGGLLAALLPLLAAIGAVCGAIAMVLVFSTFLNLDSTVMSVVTLLGLGLSIDYGLLLVARYRDELAVGHAPEVAAARTWATAGRTILFSGLTVSAALSGLLAFDVARLQTMGAAGISATLIAMAAALTLTSALLGFFGKHIRPSKKAISREARADSSEIGAFAKLARFIQGRPVVITVIASAFLVLLTLPAFTATPKLPQLAGLPRDVMESARAADVLQDKFGLAVQPPVVVVARTDAATLDQWAQRWADDPAKPVARPAEQTGENLSTVSFDMAGDSQSEAAQEFVKRVRADRPPAETWVLGDAAVIVDLWDKTVDGLPLAITIMLLSMFVLLFLMTGSLAVPLKAIFTNVLSLGATIGVMVAIFQHGFLAGPLDALVVGGLSPYILLLVSAFAFGFSMDYEVFLLGRIKEHVDEGMETNTAVRRGLQRSGRIITSAAVLVLIVFTGFTIADLADVEELGIGLFLAVLIDATLVRCVLVPSTMTLLGKWNWWTPRFLHPIRDRFGLREHEDVPTGTRRPENLEPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW1</accession>
    <name>A0A7W7WXW1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Pyruvate dehydrogenase E1 component</fullName>
            <ecNumber evidence="2 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_005134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="2 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000156">
        <property type="entry name" value="Pyruvate_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="10">
        <location>
            <begin position="154"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="11">
        <location>
            <begin position="501"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="919" mass="101695" checksum="79619F8D009829E5" modified="2021-06-02" version="1">MAPQNPGATPERVRVIRDGLAAHLPDIDPEETAEWLESFDAALAGGGQQRARYLMLRLLERARESHVGVPALTSTDYVNTIPTEREPWFPGDEEVERRYRAWIRWNAAMTVHRAQRPGVGVGGHISTYASSASLYEVGFNHFFRGKDHPGGGDHVFIQGHASPGVYARAFLEGRLSAHQLDGFRQELSHAGPGGGLPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNRYLRDRGIKDTSDQHVWAFLGDGEMDEPESRGLLQLAANEQLDNLTFVVNCNLQRLDGPVRGNGKIIQELEAFFRGAGWNVIKVIWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDGAYVKEHFFGRDPRTKELVTPLSDDEVWNLKRGGHDYRKVYAAYKAAVEHVGQPTVILAKTIKGYGLGPHFAARNATHQMKKLTHEDLKNFRDSLRIPIPDSELDPYLPPYYHPGPDAPEIRYLQERRRQLGGYVPERRSKSKALALPGDKVYEVVRKGSGKQGVATTMAFVRLVRDLAKDGGIGNRLVPIIPDEARTFGMDSMFPAQKIYNPNGQLYTSVDAQLMLAYKESEQGQILHEGINEAGSTASFTAAGTSYATHGEPMIPIYIFYSMFGFQRTGDGLWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLAHTNPAVVAYDPGWGFEIAHIVRDGLRRMYGEAAENVFYYLTVYNEPYQQPAEPADLDVDGLLKGLYRYRTAAEGGVRARILASGVALPWAVEARRLLAEEWGVQAEIWSATSYSELRREAVGVDRHNLLHPEQEPRVPYVTRVLSEDAAGPVVAVSDWMSAVPDLIRPWVPTDMTTLGADGFGFSDTRPATRRHFLVDAQSVVVATLAALAKRGEVDRAKVVEAARKYRIDDVSAAGPSTTDAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ5</accession>
    <name>A0A7W7WXZ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031266420" evidence="6">
        <location>
            <begin position="29"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="192"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1038" mass="109180" checksum="1A8288E0BDB3C4D8" modified="2021-06-02" version="1">MPRTGTAALAVAVIAAGTVAAGAGTAAAAPVSSSDTVTLITGDKVTFAGDKVTGVEPGPGRDKTTFHRFERDGHAHVVPSDAFAPLAQGKLDPRLFDVTGLIGFGYDDKHRDSVPLVVQGKETRAAGMRTTATLPGAFAATVAKSDASANWSGMLGDPNVRRVWLDGLRTPTLDRSTRQIGAPTAWEKGFTGKGVKVAVLDSGVDGAHPDLAGREIAEHNFTTDPDTVDRNGHGTHVAATIASHDPKYRGVAPDASILDGKVCAGKGCPESAILAGIEWAVDQGTDIVNLSLGGLDFPGVDPLEEAINTYSERSGTLFVVSAGNDGLPGTVNSPGSADAALTVGAVDQNDAVAGFSSRGPRLGDHAVKPDVTAPGVRIVAAKAAEGRNGEPVDDTHVAMQGTSMATPHVAGAAALLAQQHPDWTGARIKAALTGSAVPKSGTGEFDQGSGRIDVAAATVVTVVAEPTTLTFGEQRWPRQDDEPLTRDLVYRNTGDQPAVLGLTLETGAPSGLFSLSANEITVPAHGTASVRVTADTRTHPDGRHSGTVVTTGAIKVRVPLSVHSEPESYDVHLEFIGHDGRPATTHNTAWHGSAPGEQFRFLDPSVPSTTLRLAKGDYVLTSVVGESTRQALLSAPKLSVTADMVVKVDARTAKPLTVTAPDATAVHQSAIVGVAWKGESVFTNFPNGFGDLTSIGVIGPQPRLDGLYTFAATKAVTATATYMLGYIDRGRVSTGFIRKPAKKDLAEIRIDPQGTPGLSHSLAESMRLSDDQSINWFSRPATPSNLVEYVTTDVSWNWGFSQHRGDSLAADWSSPMRAYRQGQVHDLRFQVPAFNPVTRLDEQGSTVYGTSGALLMILKTYVDGGGNRGVIGAPKVTLYRNGTLVEEQNSDWVAFTKLPEGMADYRVETESTHSPEMSEYGTLVRTAWNFRFAPSATSDRTRVPVPVTAVQFTPTNGIVAAGKSVRVPFGFTGPRQRIEVAEVSYDDGATWTKVPVAGDSVLLRTPKRDGYVSLRAKGSDGKGNGFEQTTIRSFKFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ9</accession>
    <name>A0A7W7WXZ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylglutaconyl-CoA hydratase</fullName>
            <ecNumber evidence="2">4.2.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004490">
        <property type="term" value="F:methylglutaconyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="26763" checksum="AA99906A43A7207E" modified="2021-06-02" version="1">MADEVVHYSVRRGIATITLDSPHNRNALSAQVRSELGARLKAAQADDGVRVVVLTHVGPVFCSGMDLKEARGARADQQGVNEFPALLEAVLTSPKPVVARLAGPARAGGVGLVAACDLAVAAESATFAFSEVRIGVVPAVISVTVLPRLAARAAHELFLTGETFDAHRAVAIGLLNAAVADDELDAAVSRYTDMLALGAPGALAATKRMLLEPRGGNLGEVFADMLELSARHFGGAEGQEGIAAFKAKRLPSWVPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY60</accession>
    <name>A0A7W7WY60_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="79"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26358" checksum="B0C9E9F90A91FE4D" modified="2021-06-02" version="1">MGGAERSARKKKQATRAVVAARSGGDRNKVVLGIAVVVVLALVVIVGVIWSKSSSSDEGPTADGISGISAPIARDAGVVVVGPESAKVTIDVYEDFLCPVCGRFKKEYGERIKTEIEAGTLRVRYHVLPLLVKFSSPEGYSKDAANAALCAVDENKFWEFHESLFRTQPEEGGPGYTKERLVKLGTDLGITGDTFKQCVEGGKYDAVTQTEMDTTRALPYFKGTPTVAKDGQVVSLDGDWLGNLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG6</accession>
    <name>A0A7W7WYG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase (NAD+)</fullName>
            <ecNumber evidence="6">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="2"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="46635" checksum="B27C787025E7A62D" modified="2021-06-02" version="1">MIEVVNPATEEVIGTVPAGTPGLVDAAVTRAATAFPTWSTTPVEERLAVLGRVADLITGRADAFATTMTAEMGTPATFAAKVQVPNPVAIVRDVVAAASADFFAAEKVRNSLVLREPVGVVAAITPWNFPLQQMVAKIAPALAAGAVVVLKPSELAPLTAVLLGEVLSAAGVPSGVVEIIHGTGPVVGEALASHPLVDMVSFTGSTRAGRRVSALAAETVKRVTLELGGKSANIVLADADLTRAVKFGVAGAFLNNGQACSALTRLLVPASKHDEAVGIAVAAAARHRPDDPTLPTTRLGPLVSAAQRDRVTSYIRKGVAEGARLALGGPEAPRERGHYVTPTVFADVRADMTIAQEEIFGPVLSVMPYTDEDDAVRIANSTVYGLAGAVFSADVDHAVTVAKRLRTGQVDINGAAFNTAAPFGGYRQSGNGREFGHHGLTEFTELKSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYI8</accession>
    <name>A0A7W7WYI8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="27046" checksum="86DA809BD3F8752D" modified="2021-06-02" version="1">MKADPAVQRKLLDLAQVDTELARVTHRRRTLPELAEIAEAEKLVRAKQDALTLVETTAGDLGREVKRQETEIDQVRAREERDRKLLQGGTVGAKQLTDLEHELATLGRRRSALEDDLLELMERREAVDADAQHARVQLDKAQEALSDATRRRDSALADLESTEAKRTAERKIVAGVFPEPLLALYDRVREHKGVGAAVFQTRSCGACRIELDRSALSALKDAPADEVVRCEECGAILVRLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU5</accession>
    <name>A0A7W7WYU5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">F4559_006154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21259" checksum="10E77740FAFF1B89" modified="2021-06-02" version="1">MAVHPIVIAGEPVLHRPTRPVEVFDDALRTLIQDMFETMKAANGVGLAANQIGLDHRVFVYDCPDDDGNRFRGVVVNPVLETSEIPQGMPDPDDDFEGCLSAPGESYPTGRASWAKVTGFDGHGEPVSVEGTGFFARCLQHETDHLDGFLYLDRLVGRHKRAAKKMLRANGWGVPGLTWDPAVSEDPFADDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ21</accession>
    <name>A0A7W7WZ21_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="47442" checksum="C0AAB7A5A3152609" modified="2021-06-02" version="1">MGRKSNGESSIYEGSDGYWHGRVTVGTKDDGSPDRRHVQAKTRPEVARKVAKLEQERDAGKVRKTGKAWTVEKWLNHWLENIVAPPAITENAFSAYEVAARVHLVPGVGKHRLDKLEPEHLEKLYRKMIREGAKSSRAHQVHRTIRAALNIAVRRKYITENPALIARAPKIEDFEVEPYSVDEVKRLMETAQKRRNSARVAIALALGLRQGEALGLKWADVDLTLGTLTVRRSRLRPRWKHGCDDQPCGHKLGGHCPQRVALRQETAGTKSKAGTRGIGLPDELVSLLKKHKATQDKERRQAAQIWTETGYVFTTATGGPLNPRTDYTEWKNLLKAAKVPDGRLHDARHTAATVLLLLGVAERTVMGIMGWSNTAMAAKYQHITASIRRDVAQRVGGLLWEPSETTDESDDEDGAAGEPIRPSGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ25</accession>
    <name>A0A7W7WZ25_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="398" mass="39502" checksum="440FB0C121A2C5FD" modified="2021-06-02" version="1">MRLGVGQATALVLGGVLGPGVLALPAAATRAAGPAALVAWAVLLAVSVPVALSFAALGERYPGGGGVAGYVVHAFGPAAGAPVGWWFYACGVPVGVLGGALVGGSYVEALGVDARLVAVVLLVAAFGTNLAGLRVTGRVQLVLVGALVVVLAVVVVTALPRVGGFTPFAPHGWWAVGSAATVLFYAFSGWEAASHLSGEIGSPRRVTLSALVVVGVLYLGLAIVTVGVEGDAPVATLLERAFGSGVRPVTAAVAVALTFGAINTYIAGGVRLGVALARERALPAWFGRETRSLGVLGVLCVVAAAVLWSVPLDEVMRVTAVVLTAVTGAGMAAAVRLLPSGWLRRCAASALVLNAVVLAFNGLLLLVPVTLAVAALATRRVLTSGPAGSGVRGGRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXC0</accession>
    <name>A0A7W7SXC0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase (TIGR01509 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="24525" checksum="BC88E9B2D3F63F2D" modified="2021-06-02" version="1">MTLGQVPLNDPTALRAVLAATDALLLDFDGPICSVFAGLPADRVAQRLRDVLRDDLPAEVEKTEDPFVVLHYAAELGAHELRAVEAVLRDSEVEAVESAEPTPGAHDLIRTWPRTGRKLAVVSNNSAAAVHAYLDRTGLLDHIDAVSARTEPAPALLKPAPHLLHQACARLSVATGRSTLVGDSLTDLEAAKAAHTNAIGYANKPGKVELFTAERPEVVITDMSTLVSALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY37</accession>
    <name>A0A7W7SY37_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YbjT (DUF2867 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="30445" checksum="1F2B3E2B562EFE0A" modified="2021-06-02" version="1">MTILVTGATGTVGGEVVRQLGRRGVRPRALSRRDVEIPGADAVRGDLVRPESVPLDGVTALFLVAAIEEPDPAALVRDLLTRASGVERVVFLSSDAVAAQRAGSCETHEAVERAIEEISPQWTHVRPGEFMSNKLVWARTIKEEDVVRAAYPDALGAPVHEGDIAEVAVHALTEDGHHGQAYRLSGPELLTHRQQAEAIGRGLGRTIGFEALTYRQQRETLIRDVGLPYDVAEYLMGYFAQHNEEPPPLTDDFERITGRKGRTLADWAADHAGELAQTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT3</accession>
    <name>A0A7W7SYT3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpD family alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16110" checksum="79D5FA688F3272D3" modified="2021-06-02" version="1">MTNPAYVIPEAGQAIGALLRAVRQDVVPLETLMPAAVRGSQVNGGSACLHADVVEARKAGVDDDRLAAVAAWRGSPFFSAAERVALALAESVARMNDRSSDAVSDALWDEVVAHYDERQRAVLILWIATGNLFNTVNNVIKEPAGTTWGPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW0</accession>
    <name>A0A7W7SYW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030785493" evidence="2">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="37655" checksum="E09591DC5AF22834" modified="2021-06-02" version="1">MALVLGASTLLSIRSAVAEPACTTVEQDAAVAVDVARRCDARVEIGSARTETAQTFARPDGGFSTGESPTPRWARKPDGSWADVDVTLMPSADGSISPKVSVLPIVFSGGGMGPVALVRDSDRELALTWPGGALPEPVLSGADDLPRGAARCRSAIHRVSTSLVCGIRDPDRSERSEMTPILNVAVHGKYEYADYWGGMSALITEVVENLKSERVDMPWIDPGEQACFMFADGRHFADNRDWWPDNYLYVAVNRSTGYGGLTWMAGGERALNGSDGISDGIWVSDNASFPDFDPRVVSDPGFPLFYDPRSTVPISQVRLVLENFCSARTGDRPDGIEWVLGELNGQRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ1</accession>
    <name>A0A7W7SZJ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14703" checksum="DD64A12F4CF4C903" modified="2021-06-02" version="1">MTDTPRPVQDYQIEAWLGDDHGLDDERLARLRDEADRIAATWPDPDNEDERTAALTAAYRVLLGEDDLVETLAAERTRARRAEIEALAALRQVAVMTVRVGVRGRHNPDSPGAFARRAGVERSTVLGWLEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL2</accession>
    <name>A0A7W7SZL2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminoglutamate deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="47"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="44683" checksum="25455AFFFCD37BB7" modified="2021-06-02" version="1">MRNFWCERAWLPDGVASRVLVEVDGGTIVSVSTVDTIPLGAERLYGLVLPGFANTHSHAFHRGLRGRTHADGGTFWTWRESMYALAGKLTPRTYFELARAVYAEMAVTGVTSVGEFHYLHDGADDMADALRAAAEEVGLRLTLLTTCYLTGGIGRPLEGVQRRFTHGTVENWQASIARQAGGPLFRAGGAIHSVRAVPRAAVADIAAAFPDRPLHVHLSEQPAENEDCLAAYGLTPTGVLAEAGALGPRTTAVHATHLTDEDIALLGGSGTTISLCPTTEADLADGIGPARALADAGSPLALGSDQHAVIDLLLEARSLEYGERLRSGRRGNFTPAELVGALTDHAAVGWPTAGRIEVGAAADFTAVRLDTARTAGTRPDQVVLTASAPDVSVVVVHGRVIARDGVHETLGDVPRLLTRALEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS9</accession>
    <name>A0A7W7SZS9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5047 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032490">
        <property type="entry name" value="DUF5047"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16466">
        <property type="entry name" value="DUF5047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5047" evidence="1">
        <location>
            <begin position="40"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38830" checksum="59EF29565009CE4B" modified="2021-06-02" version="1">MWAQSTRAAATITRSHSVRVRATAYGRTIGTLAGLPVVDGEVTVDSGSQVRRTGTVELASPSLWPYDPADILAPYGTEVLVEYGIVVSRTVTEWVPIIRGLITQATRTRGAGGSGPITLSLADRSIRVAEDRLDAPAQTVSGATTVAEITRLIQESIPTATVVDRTGSTQVAAVLEIERERWADGVEKLADSIGAEVYADPIGTFVIRPQPLLTDPVVWQVASGRGGILVERTDDLTRERVYNRVVATGERTDGTPPVRAVVSDTDTTSPTYYGGDFGKKPYFYTSPLLTSTGMATTAATTILARARGMQASVTLDAIVNPALDAGDVIRVVDEGRTTTHIVDKLTVPLGVGGVQTISTRSVDLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZV2</accession>
    <name>A0A7W7SZV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mycothione reductase</fullName>
            <ecNumber evidence="12">1.8.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.15" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050627">
        <property type="term" value="F:mycothione reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017817">
        <property type="entry name" value="Mycothione_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03452">
        <property type="entry name" value="mycothione_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0274">FAD</keyword>
    <keyword evidence="2 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="11">
        <location>
            <begin position="4"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="10">
        <location>
            <begin position="341"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="8">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="49406" checksum="5D0892A09F570121" modified="2021-06-02" version="1">MRHFDLVIVGTGSGNSIADERFAGLDIAIVEKGVFGGTCLNVGCIPTKMFVHTADVAATPAAGARLGVDATLDGVRWADVRDRIFGRIDPISTGGRRWRAEENANVTVYEGTARFVGPKTLDTGTGEVITADRFVLAAGGRPVIPDVPDLDTTGYHTSDTIMRLDALPRRLAILGSGFVAVEFAHVFSSFGVEVTLIARSDLLLRREDHDVARRFTEIARRKWDVRPGRKTVRAERVDGVVRLHLEGPDGSEVVESDELLVAVGRTPNSDLLDLGATGVDLHPDGRVVVDEYQRTSVDGIFALGDVSSEYQLKHVANHEARVVQHNLLHPDAPIASDHRYVPSAVFSSPQIASVGLTEEQARERGVRYVAASQAYASIAYGWAMEDETGFAKVLADPATGEILGAHVIGPQAPTVIQPLIQAMSFGLDARSMARGQYWIHPGMPEVVENALLGLPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T046</accession>
    <name>A0A7W7T046_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03859">
        <property type="entry name" value="M14_CPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033810">
        <property type="entry name" value="Carboxypeptidase_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030567893" evidence="1">
        <location>
            <begin position="28"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M14" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="433" mass="47878" checksum="F79F90D62F0188B8" modified="2021-06-02" version="1">MLTKRRGLVAAAVGVCLALVVPVHSGSAQQPTAQRDDRTVFEITAATPEARSRVAKTGVDVLGLVGDKLTVIAERGQRFALAATGLPVRAVGSAESQLAALGKVDFADPQVGKLDFPSGYTAYHNYAETVAELNQTVRDHADLVKLQSIGKSHEGRDIWALKISNSPATDQAKPEVLFTCNQHAREHLTVEMCLHIIKRYTDNYASNATIKNLVDSREIWVLPIVNPDGKEYDIASGSFRAWRKNRQGPGTDPNRNWGYQWGCCGGSSGSTSSETYRGPSAFSAPETQRVRDFVNSRVVGGVQQIKTHIDWHTYSELILWPYGYTYNDTAPGLDATQQSAFSTLGRQMASRNGYTPQQSSDLYITDGSVNDWMWFQHKIWSYTFEMYPKTSSGTSGFYPRDTQIGPQTTRNDTAVELFLQYSDCVPRIINRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C6</accession>
    <name>A0A7W7T0C6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">F4559_001330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="158"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="274"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="42017" checksum="D24FC56C6C4C81E4" modified="2021-06-02" version="1">MSTPRSVLVLGSTGSVGTQALDVIAANRDRFTVAGLAAGGADPGALARQVLDFAAPAVALARATAAEDLTLALYAEAQKRGYPRGDFKLPRLLIGPSAVVDLIDSTPADVVLNGITGSIGLEPTLHALSTGATLALANKESLVAGGPLVLRAAKPGQIVSVDSEHSALHQCLRGGRADEVARLVLTASGGPFRGRTRAELDGVTAADALAHPTWNMGPVITVNSATLINKGLEVIEAHLLFGVPYDRIDVAVHPQSIVHSMVTFTDGSTLAQASPPDMRLPIALGLAWPDRLPADTPACTFDKATAWTFEPLDDETFPAVRLARQAGTAGGCLPAVYNAANEEAVAVFLADGTAFTTIVDTVDRVLAEADGWAHEPADVAEVLAAEEWARARARELVATSVGSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G2</accession>
    <name>A0A7W7T0G2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="514" mass="53669" checksum="98E9CFBE88301202" modified="2021-06-02" version="1">MFGIIRPCRNRLADDLRASWLAHLCGLCLALRDDHGHLARLVTNYDGLVISALVEAQTGPSRRSAGPCALRGMQSADVAVGTGARLAASVSLVLASAKVGDHVADRDGLFAAAPARGVGRQVARRWAKQARATGVDLGFDTSVLVDAVLRQSDVEAAAHLGSPVLVVTEPTETAAGEAVAASALLSGRPGNAAPLREVGRLFGRLAHLIDAVEDLDADRASGAWNPLLATGTSLDEARRLCDDAALGIKLALAEAEFADDRLVHRLLVHEVRESIRRAFGDPHGAHRCRTEHDHADEWRPGGPAGYLPNALGHLDGPDPVSPDRAVGAAGHPGPVPSGPRGADGVRDGGGPVSWAGTADHSAPVAADRRDGSGRGGEAGHPPYQPPPGHPHQPGHPHQHGHPHQQGHHLPSGPPPVAPGNTGGGPPPREKPRRGTGDSPGSGLWFWPKLVRPPRPRGVVPGCLAVLYQCGTCQYCCRDPYPGPWSGKAREAWCTNCDCCDGNCANCCDCCDCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M3</accession>
    <name>A0A7W7T0M3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CysZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26541" checksum="FDFDE3A620096351" modified="2021-06-02" version="1">MIRVLRDLATGFKVLGEGFGLVFRSPRLLLIGAIPALITTVLLIGGLVGLVAGIDDIAAWITPFADDWSDGARTTIRVAAGVSVLGAFVAIGLLAFTAITLIVGGPFYEHIAETVEDEHLGGVPESQRVSWLRSAGVGLRDGLLLIGIAILCAIPLFLAGFIPVVGQTVVPVLAVCVNATLLGIEVTGIPFTRRGLPLKVRRRVLRQRRAITLGFAIPVYLLCLIPLAALVVMPAALAGGTVLAHRLLARPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W5</accession>
    <name>A0A7W7T0W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030574095" evidence="2">
        <location>
            <begin position="25"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="20513" checksum="DD56219C39F9B877" modified="2021-06-02" version="1">MKSKLGVAALAAVSIMMFSACSKSTTDGTPTPATGRGTTAQTTSSSGDKQPTGNDLDITRYADKPCDLIKPDQLATLGNLKPGEPGKGPLGPTCTWSAQNPTRDNTYALSLVTRGNTLESMIENVKDDPVFKTTTVAGRDAYSTDNTDGTLDCGTGVKTSSKDAIFAQVTLGVEDTAKTGKSCQASERLAAIIIGNLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D7</accession>
    <name>A0A7W7T1D7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase beta subunit</fullName>
            <ecNumber evidence="6">1.13.11.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.3" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018578">
        <property type="term" value="F:protocatechuate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024756">
        <property type="entry name" value="PCDO_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012785">
        <property type="entry name" value="Protocat_dOase_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12391">
        <property type="entry name" value="PCDO_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02422">
        <property type="entry name" value="protocat_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26755" checksum="F10E26BD339DFB5F" modified="2021-06-02" version="1">MTRTSNTPAYRRDPASQPPVRWPDYRSNALRAPARPLTLLPQRLGEITGPLLGEGRVRPGDDDLTAGHAGEPQGQRITVAGRVLDGDGRPVRNALVEVWQANAGGRYRHDGDRHPAPLDPNFTGVGRTLTDDDGGYSFTTIQPGAYPWRNHHNAWRPAHIHFSLFGTAFTQRLVTQMYFPGDPLFPFDPIVNSVRDPRAREALIARFDLDSTVPEWSLGYRWDIVLRGTDPTPMGDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G5</accession>
    <name>A0A7W7T1G5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoskeletal protein RodZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="19236" checksum="F9745FE388173855" modified="2021-06-02" version="1">MSRGLQYFAAWSATTVVAVMLSSLGIRFVLGAGVSERPLLVPATTQQTTTTVATTTTTATTTTTTPAPTTPAAVTTTTNRATTTTTAPPTTTTTDSGTWTTENGELVRTFTLEGGVATVRYRTKDRSIEPVSASPRQGYSTRIEQPASAVVIWFTSATHTSRLEAMWAGDRPQWQIIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M5</accession>
    <name>A0A7W7T1M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen(Starch) synthase</fullName>
            <ecNumber evidence="5">2.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001034</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="208"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="413" mass="44203" checksum="4A24A5E702744FE4" modified="2021-06-02" version="1">MRVLMLSWEYPPVVVGGLGRHVHALATRLATQGHDVVVLCRHPSGTDAVTHPTADEVVAGVRLVRVAEDPAHLVFERDLVAWTLAMGHAMTRAGLALLRGWRPDVVHAHDWLVTHPAVALAEAAGVPLVATVHATEAGRHSGWLSKTLNQQVHSVEWWLANRADTVITCSAAMRTEVAHLFGVDPATITVLHNGIEPRRWRVRSTAARKAYNPDGTPLLLFFGRLEWEKGVHDLIAALPRIRRTHKGARVVVAGEGTHGSWLVDQARAHRVRRAVDFVGHLPDRDLAALLAAADAVVLPSRYEPFGIVALEAAAAGTPLVASTAGGLGEVVVDGETGVSFTPGDVAGLAAAVRSVLDDRPAAVRRARAAKARLTTDFDWSEIAAGTVGVYRRAVVRDHGPLGRPKIASGNAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z3</accession>
    <name>A0A7W7T1Z3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="544" mass="60231" checksum="E8EDCDB7E6ABDBA6" modified="2021-06-02" version="1">MSTDHETPHHGGPENGHFDVIVIGGGPGGSMASTLLADSGKRVVLFEATEFPRYHIGESLLSGTADLLKKIGALEKLERDGYIKKYGVEWVWGEHRQPWKVYFKDALAMPYDYGYQVERGAFDKMLLDNAREHGVDARERHRVTDFGREPDGTSWVAYRAADGAEGRVTARWIVDASGQGGTVTKRLHERSWDPYLKNMAVWTYWRDAKRPEGIDHGNTFLPTFGDGWWWFIPLRDGITSVGVVVDRETMRTRQESDLEAYYLEAVARTPEIADRLANAERTDELHIQRDWSYIYDKFAGDGYIAVGDAACFIDPLFSTGVHLAMLAGFLAAVTVNTVLDKPELDRAEVLAFYEKNYRAEFARLRAQVYFLYGGHGGTKDSYFWHARSQFDVPGIAPEKAFISLIAGAFTHRSWYRRFLEQLDVPAELKSTVEGIFDGKSLGTGVDPDAPLVRRDGLAVVDDLAVDGAYLRRSQSLVSPDGAVVPLTDRLTALLDSADGTRGGNELADALVSRGVPADVAQSAVHEALSYGILAAPAADTSTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T264</accession>
    <name>A0A7W7T264_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031044145" evidence="2">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="16643" checksum="255BD75DC0A2A827" modified="2021-06-02" version="1">MRPVALLVLLSALVTGCTVTVTGGGGTTTTTAAPTSAKTATTEDVAPTTEAKTTETTATFDPPALVDEGAPAQYCERTFKGALGRDMSAVVVETPAGRLTCDQAEAILFDYYTLRPDPLFGRPPLALGPLACNQASEGQLAQVVCSDEDNLIYSMWPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T289</accession>
    <name>A0A7W7T289_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4574" checksum="91D9C8BFBE099C97" modified="2021-06-02" version="1">MLFVMNCGTVRYAEGTKVLDESTERYRAQGGDIPAPPWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2B1</accession>
    <name>A0A7W7T2B1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="10" type="ORF">F4559_001409</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014069">
        <property type="entry name" value="GPSI/PNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02696">
        <property type="entry name" value="pppGpp_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="651"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="746" mass="79628" checksum="D459634798E93978" modified="2021-06-02" version="1">MTDIEVHETSAVIDNGRFGTRTIRFETGRLARQAAGSVVAYLDDETMLLSATTASKHPKEHFDFFPLTVDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVDGLRNEIQVVITVMSLNPADLYDVVAINAASASTQLAGLPFSGPIGGVRVALIEGQWVAFPTHEQLGKAVFDMVVAGRVVGSDVAIMMVEAEATEQVVDLVGEGAQAPTEEVVAAGLEAAKPFIRALCEAQSKLAEVAAKETGEFPTYPAYLDDAFEAVDQAAAADLSQALTIGGKQERESRIDEIKAAVLDKLTAQFEGREKEVGAAFRSLTKKLVRQRILRDKVRIDGRGLTEIRSLGAEVEVIPRAHGSALFERGETQILGVTTLNMLRMEQQIDSLSPETHKRYLHHYNFPPYSTGETGRVGSPKRREIGHGALAERALVPVLPKRDEFPYAIRQVSEALGSNGSTSMGSVCASTMSLLNAGVPLKAPVSGIAMGLVSDEVDGKTEYVALTDILGAEDAFGDMDFKVAGTKEFVTALQLDTKLDGIPSEVLAAALGQARDARLTILEVMAEAIDRPDEMSPFAPRVTSVKIPTDKIGEVIGPKGKMINSITEQTGADISIEDDGTIYVGAADGPSAEAAIGLINAIANPQLPKVGERFLGTVVKTAAFGAFVSLLPGKDGLIHISKLGNGKRIGKVEDVVKVGDKLRVEIADIDQRGKISLVLVNEEAEAAKPAESTDAPADAPVEAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H9</accession>
    <name>A0A7W7T2H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CDP-paratose 2-epimerase</fullName>
            <ecNumber evidence="1">5.1.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.10" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047732">
        <property type="term" value="F:CDP-abequose epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="34589" checksum="C1213DFC49F2A2CC" modified="2021-06-02" version="1">MDIAVVTGPGGPVGAAAVRALSTRFDLVVGHDVDRDDPGAVDRVLREYGTDVRLVVHTAAHPGPKPAPDSFDRAAPVAVALLDAVLAHCPDAVVVVESTVDVHGDLSGSLPLVESTTRWDLDPTHPWYEHGVDSTVFADRVDRDRRAVGVLAADLAAQHYARRHGLAVGVVRTGPVASDRYGLPARLVRAALTGTFTIRGHGGKQVRDVLDVSDLVEMFWHYYRAPRPGEVYQAGGGRARGHSVLEVIGTYEHLSGREVRFEYLPHTPFAEPRWWLTDTRGFRRDYPGWRPTRALADILTSADAFWRTSVDAFERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2S3</accession>
    <name>A0A7W7T2S3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031570456" evidence="4">
        <location>
            <begin position="28"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="407" mass="43752" checksum="A5FE3E871290D0B9" modified="2021-06-02" version="1">MSTPYRRTAALVAGVVTTALLAVPAQAAPPVRVTLPGTSGHHLIGTTDLHLVDGDRADPWHPADRREVMVTVTYPAQRGGERAPWLSPGAARVQEADVADAVTGPVDWAGTRRQARTNAPVERGRWPVVLFSPGFGMAREVNATITDDLASHGYVVVSMSHTHESRWVEFPGGRMVEGTVAGDAGTFGTALDVRVADTRFTLDELTRLARGANPDAERDPLPRGLSGALDLTSVGVLGHSYGGFTAAETMYRDRRFDAGVNLDGGIAIGGDGEPGDAAKHGLDRPFMLVGADSTDPATGQRSAHTHLDPSDPSWALFWANQRGWKRDLHFSGAAHLGFTDYQVAIPRLARVLKPGVAESVIGTIDPAKSAAAQHEYLSAFFDLHLKHRDRGLFDRDDPRYPATRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U7</accession>
    <name>A0A7W7T2U7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="16793" checksum="A948CDF44CFB5A05" modified="2021-06-02" version="1">MLWLPVDFAHPTHVPLGAGHHLRPIRESDVDLDHPAVMGSRERLWSLYGATWGWPPATMTHEQDRADLARHEREQNEHLSFNYALFDTAETELLGCVYIDPGDDALISWWVVDRHVGTELEARLDAFVPGWISRDWPFRTPRFGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y1</accession>
    <name>A0A7W7T2Y1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ORF">F4559_001739</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="30594" checksum="5E1662BAE672D000" modified="2021-06-02" version="1">MTAPGAKAEILVEALPWLQRFRGALVVVKYGGNAMVDDVLKTAFAQDMVFLKLAGLHPVVVHGGGPQIAAMLDRFGIHSEFRAGLRVTTPEAMDVVRMVLVGQVQRELVGLINRHGPYAVGLSGEDARLLTAERRGAVVDGEHVDLGLVGDVVHVDPSAVLDLVGAGRIPVISTVAPDADGVVHNVNADTAAGAIAVALDARKLVVLTDVAGLYRDWPDRDSLVHRIGAAELAELLPRLDSGMVPKMEACLRAVRGGVPEAHVIDGRLAHSVLHEVFTSEGVGTRVTGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T355</accession>
    <name>A0A7W7T355_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="21083" checksum="3C2A00106AE97260" modified="2021-06-02" version="1">MADEQTPAELTRWTIHGERLVDDTRKLNVSIAHVELPDGVHFEQWVLRMPRAVMTLVLNDEATHVLMIYRHRWVPDRWTWELPGGYLDPDEDPARCAEREAVEETGWKPRGVRLLTTFQPLTGTADFENLIYVAEGAEHTGEAPDVNEAERVGWIPLDRVKTMIEDGRIIGAAAQIGLLHVLAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J3</accession>
    <name>A0A7W7T3J3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17369" checksum="FD1B8008F6ED4EF2" modified="2021-06-02" version="1">MNSINAGGSVPDTIANADVFPRAARALIAALARHPATRLLVVGGAGSLEVRPGVQLVDTEDFARTLREVLGAPAEYERVVRAHREALDLYRVSNRNWTYLSPSGGLVRAGVRTGRFRVGGDRLLVREDGIGDITADDLAVAILDEIEIPRHVQRRFTVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R5</accession>
    <name>A0A7W7T3R5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25442" checksum="28EA66F9C18CF10B" modified="2021-06-02" version="1">MEARLVIPRTGRCPPQRGAVTGGSDSAVEEGGHSLMSERRTTGDRCRLCRDVVAWIASRDAGPAFLAGGYRRAPRLTVHSRLIHLSRRALLLITSLSVTRFLDRAHSMARHATPQRCGGGDRSRAPARRAILARSPRPAHAGGPNLRSAPPGRPRRSRAGRDGRCGGTSGHSAAPKLAAMIASNSARTHTGSAQTSSAKPRCSVSGSRAHSGPAVRGMLVPSISITPRVTVTRFLTDTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S5</accession>
    <name>A0A7W7T3S5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="468" mass="51558" checksum="4AD9B76B91A4774D" modified="2021-06-02" version="1">MTVTDPGHSVAEAVEDQRRALGTAAARNLASTTKSTPQMQGISPRWLLRQLPWVRTDAGTYRVNRRLSYAIGDGRVTFTGTGSDIRVVPQELRELPALRDLADDALLDALANRFEQREFGVGDVLVEAGRPADEVFLVAHGKVNKIGAGEYGDQTVLDVLADGDHFGDESLAGEDERWEYTVKAVTPVIVLVLPWGVVEGVAADVVRAHARAVEQGRAKPQNKHGEAAIDIAAGHTGEPDLPLTFVDYELAPREYQLEVAQTVLRVHTRVADLFNKPMNQTEQQLKLTVEALRERQEHEMLNNPRIGLLHNADLKQRIHTRGGPPTPDDLDELLSRRRKTRFMLAHPRAIAAFGREVTRRGLYPNVIDVEGTRVMTWRGVPLLPSDKIPITSQGTSSILAMRVGEDDQGVVGLHQTGIPDEYEPGLSVRFTGIDEKAIISYLVTAYYSVAVLVPDALGVLEHVEVGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T491</accession>
    <name>A0A7W7T491_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16894" checksum="0DDCA1DB22706ED6" modified="2021-06-02" version="1">MTRRDVGPPATGPGERDVLVGFLDYLRAAVVAKVEGLTDEQARTPGVPSGTNVLGLVKHLTHVERHWLLGERVRDWKATFHADPDESTAGIVAAYRQVSAEAGEVIASWDDLTAPGPRPGPSRRWTLTHLIEETARHAGHADILRELIDRRTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U5</accession>
    <name>A0A7W7T4U5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003953</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17744" checksum="A7ADD2C468D4C4D8" modified="2021-06-02" version="1">MTRVHTRIDSPMGVLTLVADTEGRLTGLYMENQRHRPAEETFGPEDPTPFPRVVEELGEYFANERTDFTVPLALHGTAFQRSVWDELREIPYGEQITYGELAARLGNPSASRAVGLANGKNPVGVIVPCHRVVGAGGSLTGYGGGLDRKRRLLDFESGTTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T588</accession>
    <name>A0A7W7T588_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20106" checksum="0F5AAD65DCD4714A" modified="2021-06-02" version="1">MHADPVFTGYTELQEVLRDGGHLDSGAGATLRALARRSLVVVWVDQVQVAPLGFVPRTLVELTRLGRSVARTGVGVPVEARRPSHLLSEWLWRSMLAVANAGDGGLPADSLAARARFYLGTGYRPQGRPSRGYIDLIVAEDLEAGHGLVAERRWVLTDSGRAHLAEHHSEYVSLYQATDSAVSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T591</accession>
    <name>A0A7W7T591_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030903588" evidence="2">
        <location>
            <begin position="24"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="657" mass="68912" checksum="657E7C1C60BBD400" modified="2021-06-02" version="1">MRFLPAVLALTLLAFATPAIAAAETYGYTATAAEPSYVEGTKRVDISGDNDYRWLGLPFPVTFYGTTYDSAYHHVDGYIDFTIWGDSNPGRQVPSPNRPNAAVYAFWDDLVVDGQAGVWTATDGVAPNRRYIVEWRDVRLKSVPGSRLSAELVFGENGVILLQYRGLDQPAERGATAVVGIEDARGTSAVVWSDNQSRLSDGTAVRLHVPGTAIARGLVTDANTGKPRSGIALSATTGGRTVTTTSDYYGRYQLEVPATDPRITASAPGYPAEVLTPGSTAEHGAVTADVAIKSPILEAPGTPEITVPAGGRTTASVPVRNTGTAPGSWSAIREVEGGAVPPRPGASGAIRSWDPRAVGVENGYGVADLDGDVWVSVPSAHQLVRLTPEGVVLGRTTLPDTESPRDLAVVGDKLCYVNDSSFAGGAVLHCVRPATAEVTPYLTTAPGIVGGQSGLAHNPRTDVFHLVDGTRLDTVKGPSHADAGALVSSCTIKFSRWDPSYYPQGAALGPDGDVWIYEETGHYQRSGRIELIDPTDCQAGTILTWSPIEGAYNAAGIEADAAGNVWVFTYPPYAGPFPSKGPANIGLFQTRYPAYSDLPWLTTLASPASIPPGSTGQVLVAVDATNLRPGVHNVALALTTTGPGTPIVGVPIRVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G0</accession>
    <name>A0A7W7T5G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9713" checksum="905A8FF86B5563ED" modified="2021-06-02" version="1">MPSAKPVGRLPGELCMWQLGDEKGLVDGYPARRRSGEGFCGYEVGLRRPETRNDRVVLTVDLRRADKTADACPATQKLTEAALGRVPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N7</accession>
    <name>A0A7W7T5N7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29116" checksum="23BB50537023127C" modified="2021-06-02" version="1">MQTEVDLELTLGATLAAVDVSAWFGQRKVLDRVSLTMGAGEVTALIGPSGCGKSTFLRILNRMHELVPAASLAGSVLLDGQDIYEPGRRITETRRRIGMVFQKPNPFPAMSIADNVTAGLKLTGTSVSRAERESLVEECLTRAGLWKEVRDRLRQPGGALSGGQQQRLCIARSLAVRPDVLLMDEPCSALDPTSTRRVEETIADLRTEVTIVIVTHNMQQAARVSQHCAFFLAEDGTPGHIVEQGRTSTVFSDPVDPRTADYVNGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R8</accession>
    <name>A0A7W7T5R8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035099">
        <property type="entry name" value="Anthrax_toxin_C-terminal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81298">
        <property type="entry name" value="SSF81298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="25712" checksum="8E75B46472434F09" modified="2021-06-02" version="1">MPTEHARKFQYVAATQDIVIDVRSTNPHSVAWLKAGALPKPEAVKAKTIDEPDLHLGATPRQRGLVGYFRPLRPHTRDQSLLRRYEQRRAEFATLRDKMDLLARRDEYHVVDGVVHGYDARGRLQPLTGDHDIFDIHTSGGTVLGERRYRHAITTMVNLRMGVTHGAHMFWNPTTAADRAIFESIALGDGPKLRFHPDGTMTSGDYRRTDAATPIRRRVPAHLEAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z3</accession>
    <name>A0A7W7T5Z3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="32798" checksum="9F4B1FC50E32A53A" modified="2021-06-02" version="1">MSRSYDVCLSFAGEQRAYVEEVARLLRAGGVEVFYDQFETADLWGRDLAVHLDDVFRHRSRYCVLFASADYARKMWTSHERASALDRALRDRDDYLLPVRFDDTEIPGLRRSTGYLDARRLSPGEIVAALIKRIGAGDSLAVPCTILAVRGSVDVRRLFDDASRECGIAVDVVGEHGVVPLDRVSTGDVVRRLVPVLAESRLVVGVHRGEVPEGDSVDLAVASALVEVTDAERAVVLSQRVYDEVVRGSGRARQYVGVPLASGGTAWVRGSGRQGGATGARVTVIGDNAVIGQVGDRHDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T647</accession>
    <name>A0A7W7T647_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding ferritin-like protein (Dps family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008316">
        <property type="entry name" value="UCP029876"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06304">
        <property type="entry name" value="DUF1048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13280" checksum="BEFB333CFC741205" modified="2021-06-02" version="1">MTFWETVTGSDITREWNAFEARAEALPTDHRTAWEEIKDHLSTYSDFTGRNLTPILDAALTLLEETAADGQGIHEVLGDDVKGFCAALAGGERSRDYRDRWREQLNRNVARKLGRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T680</accession>
    <name>A0A7W7T680_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030763059" evidence="2">
        <location>
            <begin position="33"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="632" mass="69150" checksum="AF767E031457B03B" modified="2021-06-02" version="1">MTTALRKRTPPMVLVAVVAAQLLATTAATAAAAHGPRDFEVQSYDGSGNNRAHPEWGRAGEAYPRVAPAHYADGIGAQVAGPAPRRVSNRVFDSRGQNLFSPRGVSQWSTAWGQFVDHTFGLRANSAERGTVRFDPADPLERFTSDLPTMPFSRSTVVPGTGVTTPRQQPNTLGSYLDAYAVYGADPARLEWMREGPVDGDPTNNGARLLLPADMLPRRDARGDTTTAPGMDTALGATARLAVAGDIRANENIALLAVQTLFAREHNRIVARLPEALGEETRFQLARRVVIATQQWITYQEFLPSLGVRLKPYQGYRPTVDAGIGNEFATVGYRAHSMVADEITVTTEATRYPAEVRETLRAQGVRITDLADGRLELTVPPSIIIFNPDLLDRLQLGPVLQGLGARPQARNDELIGDVVRSVELRSPDCPPTCLKAVLDIAAFDIERSRDHGMPSYNDLRRAYGLTPKPTFRAITGEATESFPTDPELTPGAEIDDPNSLDFVKLYDARGATLEPGTEAAKTSAVRGVRRTTTAARLKALYNGDMSTVDAFAGMMSEPPVPGTEFGELQLAIWKRQFEALRDGNRFHYQNDPVLSLLNQRYGIDYRQSLTTLIAKNTDIPRNHLPQNPFFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y2</accession>
    <name>A0A7W7T6Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl diphosphate synthase type I</fullName>
            <ecNumber evidence="3">2.5.1.1</ecNumber>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
            <ecNumber evidence="3">2.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EC" id="2.5.1.29" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="38075" checksum="43232AFCB5BD87C3" modified="2021-06-02" version="1">MPLHPLDLDLPKHVDAALAGYLADRRSLGERMEANFTGAVDALADFVLGGGKRIRPTFAWWGWRAAGGDPECAQAEAVLTAVSSLELIQACALVHDDLMDASETRRGRPTVHVEFARRHREQGWLGEPARFGLAAAVLIGDVALAWADDMLFAAGLPTDALQRLSLPWRDMRTEMLAGQYLDVLTQVRGDASADAALRIDRLKTAAYTVERPLHMGAAIGGGSPELIDGLRAFGTDIGVAFQLRDDLLGVFGDPTVTGKPAGDDLREGKRTLLVALGIERGADVLEHALGRPDLDVATVDEVRARLVEVGAVAAVEERITELTESALRALDRAPVAEPAGDRLAELAVSATRRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T774</accession>
    <name>A0A7W7T774_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative PurR-regulated permease PerM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003869</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38672" checksum="885CC03890AAAE3C" modified="2021-06-02" version="1">METTALPRALVLLLGAASAVIVVAGLRALAWLVGPMLLALLVVITISPVRRWLRRRGLPDWTATAGLVVLVYLVLLAFALVVAASAARLGELLPGYADQGRQLLVQTAATADRALGHTGALKELADKIDPSWLVAQAGALLASIGGLATNLVFLLALLAFLSVEVAVVDARLDRFDRPELTVALREFAHRSRRYFVVTTIFGLGIAVADTIALLWLGVPLALLWGVLSFVTNYIPNIGFLLGLAPPALLALLESGPRTAIAVCVLYVVLNFLGQSVIQPKFAGGAVGLSATAAFLSLVFWGWVFGPLGMLLAVPATLLATAVLVRTDPRARWVEALLRTHPGRVKTTTVQPGNLAGGSDRKPEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T787</accession>
    <name>A0A7W7T787_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="462"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="678" mass="73998" checksum="5D12235C72904BAA" modified="2021-06-02" version="1">MTDRTVEADDFADLASYVALPRVGSLALSPDGTRLVVVVSELSPDGKRYQGALWEVDPTGHAPARRLTRSAKGESTPRFAPDGGLLFLSARPDPEAKSDATDKDKTALWSLPPAGEARELHRPAGGVADFVVARDNGRVVLVSAAHPGLGFGEDDRERRKEREDAGVTAVLHESYPVRYWDSDLGPSYPRVLASAEPVGAERVERLVDLTPDNARRLGESPAVSPDGAWVAFVEQVDVSPAYGARQRLVVAAADGSSRRIVAESPEFSFGSPAFLPDGRSLVALRIFESSADEPWHHHLIRIDLESGASTDLAPDFGEEPEHPVVSPTGDAVYFTGSRLGHQPIWRVDLASGEVVRLTASGSYTDVAVGPDGATVYALRSAWDATPRPVRLDAHAVEQEAVELPAPGAVRSLPGTLTEVETVVEDGRTVRAWLVLPEGASAERPAPLLLWAHGGPVASWSGWSWRWNPWLMASRGYAVLLPDPALSTGYGRDFVRAGWGSWGAKPYTDLMEITDVAERLPEVDGSRTAAMGGSFGGYMANWIATRTDRFSAIVTHASLWHMDAFTGTTDDSYYWIREMGDPLVRYDRVRDNSPHLRVADIKTPMLVIHGAKDYRVPVGEGQRLYFDLVRHGVPAKFLYFPTENHWITSPGNATVWYETIFAFLAEHVLGEPWRRPGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7B6</accession>
    <name>A0A7W7T7B6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannose-6-phosphate isomerase-like protein (Cupin superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="12971" checksum="F7B5DE5A664A2FA8" modified="2021-06-02" version="1">MHVVEETEDRTTRTAAATMTALAGPSRGSAELSTWRVRMSAGTESPPHVVDRDQVWMPVAGTFAFTTPDGSAEVTAGQAVVVAAGEERRFRTVDGPAEALVCMHPDGRAGVVGSGESHPLPWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I3</accession>
    <name>A0A7W7T7I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="45143" checksum="04297DA7C1DC3365" modified="2021-06-02" version="1">MTGGNPLIAPVQDSTRWYSGIGIAESAADLKSGIESGSWIDIGMGVAGVGLEALSIVIDPLGSLLSAGVSWLIEHVKPLSDALDWLAGNADLVASHAATWKNVAKAVAEVRDDYTRDVANDTAGWQGQAGDAYRAAAGNTAEVLGGASTAADGFGSAVEMAGVVVAVVREFVRDLIADLVGRLIAWALEVAFTVGLATPVVVAQASAAVARWGAKIGDILKKLVRTISKLVPLLRTLGDVFDKVRKVLDDLKTPARSGDELPRPGQTGGARPVDDGSLRAYDRIDRWSENAYQSIRGSDDIGDVAGHVADVPRVGGGTGFTRAEIEQIKNHVFEDLHPLEGVDGGTVMARFDPNPDMAEAWLRLRSGQAQPSDIALLEHELAEARYWQQNPNASYKDAHAAANEVSRWETQIPPASNEDYSKPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L1</accession>
    <name>A0A7W7T7L1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="315"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="42793" checksum="F8AD469BB3B84FBE" modified="2021-06-02" version="1">MLAPLWTAVRYLLVGAVTSFLAVFALVALAVVGAFCLIGVGLPAVPEVLRLVRRLVAYERRRAGAFLGGTIPEAYRTPAGPLSRQVVTAVTDPATRRDVAWLAAHAAVGMLLGGCAIGLPISAVNHVLIPVYWWLVPGGVVTSFGMVVDSWSTAPFALVVAVVYGALSVRLPSAARWQASFARWLLSPAPGVRLTDRVAELTASRAGALEAHGAELRRIERDLHDGAQARIAAVVMQLGIAGQLRDRDPDRAFELVVKAQDTAVDALAELRDVVRSIYPPVLSDRGLDGALSALAARCPVPCTVEVGRIGRRPAAIEAAAYFIVAEALTNVTKHSAAEHVVVRLDSTDDTLLITVRDDGRGGADERRGTGIVGIRRRADAFDGRADLSSPPGGPTVLRVELPCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y7</accession>
    <name>A0A7W7T7Y7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">F4559_005320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23194" checksum="6CF1863DFCB18D5B" modified="2021-06-02" version="1">MSQFHAPQSRYVLPSFIERTSLGIKETNPYNKLFEERIIFLGVQVDDASANDVMAQLLVLESEDPDRDILMYINSPGGSFTSLMAIYDTMQFVRPDIQTYCLGQAASAAAVLLAAGTPGKRHALPNARVLIHQPATEGVYGQVSDLQIQSDEIQRVRRLLETTLARHTSRSPEQVRADIERDKILTAEEAKDYGIVDSVLPYRKLSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T809</accession>
    <name>A0A7W7T809_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="106"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="49986" checksum="BDD85A79027451C8" modified="2021-06-02" version="1">MNRQQEFVLRTLEERDIRFVRLWFTDVLGFLKSVAVAPAELEGAFSEGIGFDGSAIEGFARVYESDMVAKPDPSTFQVLPWQTPDKSLYSARMFCDIAMPDGSPSWADPRHVLRRTLARASEAGFTCYVHPEIEFFLLKNLPDDGSAPIPADNGGFFDQTSHETATHFRRHAIEALEAMGISVEFSHHEGAPGQQEIDLRYADALTMADNVMTFRYVVKEVAITQGVRASFMPKPFTDQPGSGMHTHVSLFEGDRNAFYDAEDPYQLSDTGKMFVAGLLKHAREISGVTNQWVNSYKRLIVGGEAPTAVCWGHANRSALVRVPMYSPGKSASRRVEIRSLDSACNPYLAYAVILAAGLKGIEKGYELPPPAEDDVWSLTDRERRAAGYANLPQNLGEALSEMENSELLPEALGEHVYDFFLRNKRTEWDAYRRSVTPYELRTLLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T857</accession>
    <name>A0A7W7T857_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="35258" checksum="FB7872D088CEDBD9" modified="2021-06-02" version="1">MATRRPRVTDWRLVVQSRLDRVRADLSALDPLDPLDPESARWREVAVEEAAVVEDMLTREESRWRTVASWWSGWHIERAWRSLHEAEIAVVAAGNGFLGRLPGLRGRVGEYLDDDDPRRVALDELRPGEFPLSVEREIVVDALRAAFDRSDFAHVGSRALRNKLIAASVVLFAVNTLIGLIGFLQPGFIPTCVGSERLPTVCPSGRDAAGTDVWLVQVLGAFGAVLSAVVLLLRRRPSLSPYVMIGYQATIKILLGASLAVVGILALGAGVTTGLIGVASQAALLLWAVILGYSQQVATRLLDSYADRVMDQARPLPKAEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T861</accession>
    <name>A0A7W7T861_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030921311" description="Phytase-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="53"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="329" mass="34533" checksum="9E03B8D77239BAD1" modified="2021-06-02" version="1">MRSLAVLGITAVLIAVPTTTAQAAPAPITVPGYEFSLIGEYGLAGLTRYQGTVVGGITGADYDQATGEFRLLSGDRDNARFYTGSLSLSGACPKPKITGVSRLRGTSAGVDPQALRYDTATGNVLWADAGSVTKKLDPSVREADKKGNAVARFATPDVQKVGVQKGLSLSGLALTVDGVAVLTTTRGPLAQDGTLIRFTLHDRASGDPLVQFAYGSDTGAEVTELLAVTETRFLVLERTGRDAKLYEVDFANGATNIADVPALAGEQVDTLSKRLVLDVSRLGVRTDELEALTWGPVRADGARSLIFVSDNHLKATKRTQLIAVKAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P2</accession>
    <name>A0A7W7T8P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="355"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="712" mass="77905" checksum="B72779C89DC67C58" modified="2021-06-02" version="1">MTRRPEREMVPMVFDGEMIDDETVVPQGQSVPRLTFPRWRAVAGVAGGRVRAVVRCPAVVHARSVAGYRVRQAPRDAVRLVWFLVRGVGRWGAKGWRWGSHADLRADARAARLAGDVQARRTAQETIRADARARWAKAGTVVRRTVVGAAVTTVVLVLLALGEMVAGREVMPGWLRAVYAVRDAIGHGVAGGWPWVWRSTVCALVCAAVWEGRDRTPGASWITRPDRDDDGSWVDERMISKALAHLGIAPLNAFLRGGGELVYTVPARRDGDGTHARIRLPLGVTADMVCDRRRVLAANLGRSSLETWPTTGEEDGVLDLWVADKGTLSGGAGDWPLLHEGTVDVFDGVPVGLSQRGVVVAPPLPESNWLIGGRPGQGKTNLLRVLLLGAALDPTCELWVFVMGESPDFEPLRPRLSRYRMGLDDTVAAGAVRALEDLCSEMERRGRILGEQPGRPPKVSRRLADKPALGLHPLILAVDECHELFQHPTYGRKAEEFAVRLIKRGRKYGITLMLATQSPTKDSIPKEITRNISCGAAFAVADHIANDGLLGSGKYRAGIRATELRMRTDRGTCVAVGITDATFELVRTFYVPFEDGADLVSPVIARAMAHMTDAKRTVVTTGGTRKEIDTTPADHLKDIYSIIGEEPRVRTQVILARLAAHNPREYEPWSLRDLRATLRSYGIRAYKSDGTMVLRAADVAEAISRRDLASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8R1</accession>
    <name>A0A7W7T8R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="2">
        <location>
            <begin position="73"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="329" mass="36515" checksum="A09D936E153E0A89" modified="2021-06-02" version="1">MISSELDHRRAARIQPGQGNLGDVNASTEGDATGDFSSGHTGRALRAACEAAGLNATGASLIRTGENALYALADEPIVVRIARTMDYMAQARKEVLVSDWLQGVGFPAVRVADVDNQPLSVNGHPVTFWQFIPGGSAPKDRVDILAQLLRRLHSLQLPSDRVIPQFRFGDRVKSRLEKSDAPVEDVTFLLERFESLAAQVRDLDFPLDPCIVHGDAHMGNVMLSDTENPILIDLENVGIGQPEWDLTVAAVECATAKLMSVEKYGEYVEAYGFDVTRWSGFDVLRQIQEIKMTTWLMQNIRHSREILDEFSARVYALRNGHSGRVWRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S9</accession>
    <name>A0A7W7T8S9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="33432" checksum="ECBEAE2970FD6BA2" modified="2021-06-02" version="1">MAPETRVLYITGWMRSGSTLLGNVLNELPGVLHVGELHYLWRNGVLKEGTNTLCGCGQDLTQCELWSAVLYADGSADPSAARRMVAQQRHYLRTRHTAARLADWRRGGRPPRGVVEATGRTAGIYRGLAGNGAGRLVVDGSKYPGEAAALLGREDLDVRVLHMVRDPRPTALSYKRAKDYIDPMSPAGSSAYWTAFNVASELLGRAAPDRYLRVRHEDLCADPRGVLTEVMEFAGLDGEPPVDADGRVTLGVNHTVTGNPDRLARGATTIRADDRWRSALSTREIVAASVPALPLLARYGYRHLPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T4</accession>
    <name>A0A7W7T8T4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="5" type="ORF">F4559_004754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="193"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="518"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="648" mass="71630" checksum="1C69292ED98B061A" modified="2021-06-02" version="1">MDGDTTPGRLVVDDVSPVVSSGRWPAKAVVGQHVTVAAEVWREGHDAVAATVVWSGPDGVRRETRMRSTDPGSDRWAAVIVPDAVGEWEFRIDAWSDPWSTWTHAVRAKVDAGQDATELANDLEIGARLLDAAAAGEGVSTRLRDETLPLAERLAAAFDPTVLAHLDEFPVRELVTEGTPLTLWVDRPRAAFGSWYEFFPRSTGGVDAAGRPVHGTFRTAATGLERVAAMGFDVVYLPPIHPIGEVNRKGRDNTLDPGPDDVGSPWAIGSAHGGHDAIHPELGTVADFEAFVAEADRLGIEVALDLALQCAPDHPWVVEHPEWFTRLPDGTIAFAENPPKKYQDIYPLDFDEDPGGLYAAVLRVVRYWIDRGVRIFRVDNPHTKPPDFWAWLIDRVHHDRPDVLFLAEAFTRPARLYGLARLGFTQSYTYFTWRDDKAELTDFGRELLAHAHESRPNLFVNTPDILPVPLHDAGPAAFAIRAALAATLSPTWGVYSGFELFEGEPVRPGSEEYAHSEKYELRPRDFAAARAEGRSLEPWLALLNRVRRAHPALWSLHGLTFHDVDNPKLIAYSKRDPATGDTVLVVVTLDPDHPQEGTLTPDHTALGAERDFIVRDEVTGQVWEWGERVYVRLDPARAVAHVAAVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X9</accession>
    <name>A0A7W7T8X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18718" checksum="FCD5417159E6D6FC" modified="2021-06-02" version="1">MDTQVQVSEYVAGRYHRPGDWVVDTPEGVRAAVDALFERHGDKVTTRAIVERLGEDALLGVLVDPVTGYVALHWCFGEHSLNPEPFADAPLVPEDGDNDPLNFWMRDTYVAEADARRAIEEFVATGNRPTAVRWQPWGWEAYELPDWYDDEGRDETGGRYHLITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F2</accession>
    <name>A0A7W7T9F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10997" checksum="C4816ACC9654DD55" modified="2021-06-02" version="1">MSRWRSTRTGSGTFTAARIISGIGAVFALIEVLYILMILFGANQGNAFFRFVQSLAEPLALFFPGLFDLGNYNLGVLLNYGLAAVFWLVLTGFIARLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F4</accession>
    <name>A0A7W7T9F4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031162376" evidence="1">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="10264" checksum="E23F88EB90F47C15" modified="2021-06-02" version="1">MVTVEAALGVSGLVVVLALCVQAVMATVAQIRCTDAAVEVARLVSRGEAARAGEVVARAAPPGARFEVRTSGDEITVRVTVEASLVQVAGTAFALMEPDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K2</accession>
    <name>A0A7W7T9K2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17194" checksum="FBFA2DC72B4EFDF5" modified="2021-06-02" version="1">MAFRDLGELLDAGLALPIRGKVYTVPPVNAETGLRLQRLAEVAAQVADAAENGGSLDGVALDDAAEVDLYRDALGPVYDEMLADRVPWPALKLAGVTAWLDAAVGREAAEAYWNAAGSPNSTAGNRASRRTAARSTRQPASASGTTRTRKASTAKTATGTRGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA77</accession>
    <name>A0A7W7TA77_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="27370" checksum="6F4558A5546FD7A3" modified="2021-06-02" version="1">MALLAVERIKLFSTRSPWWCMLLAFGATIGITSIIAANWNNSPMPVVGAVFVHTLGLYVTMVMATLAVTTEYRFGTIKSLFQAVPDRTSALLAKAVVVAVLAGLVGEIAAFGSWSMSWLLTSDHSQLAIESANDWRHIAGVGLLYAAGAVLALGVGTLVRQTAGAVSIILVFALVIEGLVSLIPNIGDDIREWMPFTVATKFIFGDTDPMGLPGAEGQMEAAGPPAIGELSPWGSFAYFAGIAVVIYVISLVVAKRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA94</accession>
    <name>A0A7W7TA94_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="32583" checksum="AAB0E257B1F16352" modified="2021-06-02" version="1">MDVRQLVAFRAVAETRSITRAATALGYSQSAVTAQIKNLESVVRARLFERRRDGVRLTSSGERFLPYVTRLLRLTEEARSAVAPEAEPRGTLTIGASEAITTYRLPDVVWRFHARHPDVRLALHTFHEGPQSLVTALERGEIDVALLHSTGPVGPASRRLAVEELVLVAAPTHSLVGRDVVTVDDLREQSTLIVQSACVYDAVMRAELGHRPVPPLEYGTIEGAKIAAVAGHGVALLPRVCVRSTLDEGRLVALPWMPVTTVAGYLVWDDAQCDPATLAALDAVLTRAVADWERPRATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAA0</accession>
    <name>A0A7W7TAA0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22170" checksum="3250821A0DBC0381" modified="2021-06-02" version="1">MSTVESSAAVAPPIGQQFNLAVSNDSTAEINVMLFASMGGGQPVTTLVWRSLRLVPQQAISFGWTYTLNFVLGAQGQLGPGENYDPVQILDAVPGVSNQITLALVDGHLQLVDARPGPPGTLLIRQDDDLPPFSGNVGVGIDGLGTFITNVQPSTQQGFGYAPQLWIGTGTFEQGQMMSTMGINTKAALTFPAGVDHAQAAFDGSSWSIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAA9</accession>
    <name>A0A7W7TAA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32398" checksum="59422AC344078716" modified="2021-06-02" version="1">MIEAISLTKRYGKTVAVDDLSFTVEPGRVTGFLGPNGAGKSTTMRMILGLDNPTSGQVLIDGQPYAKLHRPLTKIGALLDANWVHPNRSAHAHLRWLAKSNGLPDQRVDDVLEMVGLSGVAKRRAGGYSLGMKQRLGIAGALLGDPQVLLFDEPVNGLDPEGILWIRRFMQNLAAEGRTVLVSSHLLSEMALTAQDLVVIGRGKLISQSTTAEFVDRSTEGTVLVRSPHADKLGAMLVDKGFTVKADADGALTVLGASSEEIGEIAASQNVVLHELSPQRGSLEEAFMQLTGDAVEYHATGTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF9</accession>
    <name>A0A7W7TAF9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10673" checksum="B8C98436F85BED90" modified="2021-06-02" version="1">MRRLWVDDLRPAPDGWLWAKTSAEAVRVFEDGPVDAVSFDHDLGGDDTTRPVVLWLCERDVWPPVVHVHTANPVGRDWLVGMSRRYGPGVTARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTG5</accession>
    <name>A0A7W7WTG5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="7132" checksum="A70FF0B439BA9747" modified="2021-06-02" version="1">MNGEFEPLWTVADVSAFLEVPVHTLYGWRTKGYGPPARRVGKHLRYLPGEVRAWFVSLDSEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTQ5</accession>
    <name>A0A7W7WTQ5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="19" type="ORF">F4559_000092</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBB4962733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="37051" checksum="808C206BF0FB6561" modified="2021-06-02" version="1">MTTPLSGTGVPLSQCTTLRLGGPATRFVRATAAADLVEAVRDLDASGDPLLLIGGGSNLVVADEGFAGTAVQVGTLGRRLDPLGDGLVQLTVEAGEVWDDVVAEAVAQGLGGLECLSGIPGLVGATPVQNVGAYGVEISQVLDSVDLLDRRTGRVHQLPASALGLAYRTSVLKGTDAAVVLRARYTLTSGGLSAPIRYAELARVLGVGAGDRVPADAARKAVLELRRGKGMVLDPTDHDTWSAGSFFTNPLLDDSTFTGVLIRIAERLGADVDVPSYPAGPGYRKLSAAWLIERAGFAKGYRGHRVALSTRHTLALTNRGGASTRDLLGLAREVRDGVRAAFGVELTPEPVLVGCDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU03</accession>
    <name>A0A7W7WU03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="16766" checksum="34BAF9DFB36E698A" modified="2021-06-02" version="1">MMIRRETPADVDVIREVTSAAFAARPGGEAGLVDALRADPGWIPALSLVAEVAGEVVGHAVATRASIGVGLGPVSVRPDHQRAGVGSALLHAVLGAADALDEPAVVLLGNPAYYARFGFVLAADHGITPPVAEWAPHFQVRTLSAWTPSLAGPFTYAAPFSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU13</accession>
    <name>A0A7W7WU13_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ORF">F4559_001065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10553" checksum="5C1277C933A48683" modified="2021-06-02" version="1">MPSISRDEVAHLARLARLAVTDDELDLFAGQLDVILQSVATVGDIATADIPPTSHAVPLTNVFREDVVRPSLGQRQALAGAPAAEEGRFRVPRILGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU78</accession>
    <name>A0A7W7WU78_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular small neutral protease</fullName>
            <ecNumber evidence="3">3.4.24.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Snapalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031273828" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="36"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20292" checksum="AE6E1293C9DEE1C1" modified="2021-06-02" version="1">MTTTLRRTAGSLAAAFTLVLSFALVQGFGGGTAVAAPAPTAVRVVYYDASQAQEFKAAVDEGAAAWNKAVRNVQLKPATGGNAAVRVYADNGWPRTYQSGFGRGTVYMGREAVNDGFYPPRIATHELGHILGLPDNRNGRCDYLMSGHSSPVSCKSTTPHSTEAAQVERNAGGGIAALARDSRESAFADCFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH3</accession>
    <name>A0A7W7WUH3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26775" checksum="C141CA68ED459F73" modified="2021-06-02" version="1">MTGEVYVLVSDDEAGLQVHGVFEAEADARRIANELDEDGDCGYDVRPLGYWPSGTAPTVYEEWEVAIIRDSPDGQSIYTEARRCLESDLRPGRATVERDESGRVLSITATAATKAAALAKAEATADAYRGPRCLAHRQDGPCWSDRNWCLLPAAHGEDCEFGAFPEPVVVDSDSDVLYFRLFDQRHRVPRNGGGVVALADAGPYLVYEPSLPRMWYPCVDEAEARVVQASRQVQRGRIPRGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY7</accession>
    <name>A0A7W7WUY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="211"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="503" mass="53178" checksum="D8F5F708FF8D63A2" modified="2021-06-02" version="1">MGLSRAWSVALYGVDGVPVEIEADVGVGTVRTQLLGLPDAALHESKDRVKAAVRNSDRSWPTQRVTLGLSPATLPKGGSSYDLALACAVLAAAGSVSSERLVGTVLLGELALDGRVRAVRGVLPALLAARRAGLTRAVVPVECLPEATLVEEIELFGAETLVDVIMWLDGGTSLVVPSSGAFVAMPPSGPELADVMGQPEARWALEVAAAGGHHLLLSGPPGTGKTMLAHRLTSLLPPLTVEDALGVTAVHSVAGLLTPDMPLVSAPPFVSPHHSTSTAALIGGGTGLPRPGAVSRAHCGVLFLDEACEFGQSKLEALRTVLEEGEIRLARRDGMARYPARFQLVLATNPCPCAPPKEVDCLCTSTARRRYQAKLSGPLLDRVDLRVKTRPLIAMNGAEVVEPESTAVVRARVQRARERAMRRWSEHGWRTNAQVPGPVLRKEHVLPRSTTALLDRALATGALTGRGADRCLRVAWTLADLADSPEPAAEHVATALEFRERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUZ0</accession>
    <name>A0A7W7WUZ0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11810" checksum="DAE53707FFF0A304" modified="2021-06-02" version="1">MDLRVRNEVRGDWTVVAVSGELDADTVPVLSDHLEETPGDRVVVDLSGVPFMDTTGLSLMLDWHRRLDGTGGQFRMAALQPSVHKLFRLTELTEVMHIHESVASATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV26</accession>
    <name>A0A7W7WV26_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="23640" checksum="0B59EEEEBD433651" modified="2021-06-02" version="1">MRPDAVHSVLDAELTAARARRGGEPPRVLDVGGGSGVWAVPLAVAGCSVTVVEPSPNALATLHRRASEAGVLDRITAVQGDTDALDADGSADLVLAHGLLEVVDDADVALGALAASAASGGAVSVLVPNRFAAVLHRALAGKLVDARRLLDTPGPADRPRRFDVADLEALVVGAGLKLEVLQGHGVVSDLVPGAVLESSPGAADALAELELAASRRPPLRDVAARLHVLARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV82</accession>
    <name>A0A7W7WV82_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SEFIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEFIR" evidence="1">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="822" mass="88503" checksum="1499F8703B1B8BF6" modified="2021-06-02" version="1">MAVRVFLSYAHESDEHASIVRELWLLLRSCGVDAVWDGVAAQSRRDWALWMGDQVRAADFVLVIASAAYRERAEGRVVEGRGVQWEARLIRDAFYADQVRGIERFVPVVVPGQTVAGVPDFLAPASSTVYEVPSLTLPGVESLLRFLLDQPAEIEPPLGPVPEFGRPSVERLPAGSEVFVGRVDELARLEAAVASSGRAVVVAVHGLGGVGKSTLAARFARLHADRFSPTWWITADSPTALDAGLADLAAEVVPGELPSEQRADAAVRWLTGHDGWLLVLDNLTAPADAARLLARVRTGTIVITSRRGSGWRGLAESVALAVLSPAEALDLLERCVRVEWPDADLTGGAELCAELGFLPLAVEQAGAYLAQARITPTAYLDLLARFPARMFTATAEGGEAERTVARVWKVTLDRLADTPLAGDLLRIMAWFAPEAIPRHLFDVNPDHVAVVEALGRLAAHSMITLDRDTIAVHRLVQAVSRTSDPADPHRDADDISEALEVATDLLAHVLSGLDHENPEDRPVYRVLLPHARALLDRVEVDGLAACRVLDRIGRYLAGAGDTAGALAYHARAVRGMSVLVGEEHPETLVARCGLAVARMAAGDHGGAIESLRVLDADAARLLGPSHPDVLVVRHELALAYGLAGDHDQAIALSRAVLDDVVRIFGADHPRTLACRNNLAAMYQYVGDHDRAISVLETIVAEAGRSSGVDGHLTLTGRANLATALLKRDPHRAIPILEQVLEEVDRRYGSDNPNTLVCRNNLAGAYLEVDDLDRAISLFESVLVDRRRVLGDGHPDTRETEMILTLARRVRESGGPAGSGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ6</accession>
    <name>A0A7W7WVJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phage baseplate assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02243">
        <property type="entry name" value="TIGR02243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="397"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="640" mass="68604" checksum="AC60CED85181528D" modified="2021-06-02" version="1">MVLPAPNLDDRRFQQLVDEAKRYVQQSCPEWTDHNVSDPGVTLIETFAHMVDQLVYRLNRVPEKNHLAFLDLLGVRLFPPTAARADVTFWLSAPQPDTVLLPVGTEVATGGGDADEAVVFATSAELPIVPSSLTRLVTVSARGDHVDRTRDLDSGRDVPCFQARPEAGDATLFGLSAPVPRCAVVLRLDSRVEGIGVDPRQPPLVWEAWDGHDWVACAVDSDATGGLNRPGEVVLHVPAGHAASVVAGHRAGWLRCRVTSPLADQPFYSESPTVREAEAFTIGGTTTVEHAEVETDVVLGASAGVPGQRFRLPTAPVLVDGPPVVVQVSNGAGWDDWTAVEDFGSSGPDDRHVVLDAALGEIWFPPAVREPDGTLRRCGAVPAKGGMIRVPRYRTGGGRAGNVARGAISVLRSSEPYVSTVENREAASGGVDAETVDEAKVRVPHQLRVWDRAVTARDHELIAHQAVPSLARVRCLPEAGGARVLVVPDAVADSGDRLRFEQLLPSDEVLAAVARRLDERRLLGTRLVVEPPRYQGITVVARLVASSGRVHAEALDALYRYLNPLRGGLDGTGWDFGRAVGYGEVFAVLQRVPGVASVAEVRMFPANPLTGERGAATERVELAPNALVFSQQHQIAVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN8</accession>
    <name>A0A7W7WVN8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ANTAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17517" checksum="0E7D7E460094CF21" modified="2021-06-02" version="1">MVGDDGLDDSLTARIAGLEAEVLGLRNAVRTRTVIGQATGLIAAVQGCSPQEGFRLLVRMSQHHNVKLHTIAVRLVDLAAELGPRRAVRAVHLTPQRPAEWPGTEVVEAARDLVEAHDAAEREHRPDERRRLADLVAQATKELVERLAEVGWLPDDGLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS5</accession>
    <name>A0A7W7WVS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YkwD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030998211" evidence="1">
        <location>
            <begin position="32"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="43"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17175" checksum="F608583F9F836A2D" modified="2021-06-02" version="1">MNIIARRIATAAIATGIAVTAFLSANAAANAATTPPSFEAQVLTLTNKERATAGCPALAANAQLNASAKAHNDEMAKTGKMTHTGLDGSTPSQRIDNAGYYWKMAGENVAVGQKTPEQVVKDWMKSPAHRANMLNCGFKDLGVAYTVDAKKKAYWTQNFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV6</accession>
    <name>A0A7W7WVV6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9050" checksum="25C88AC54DCBA7FA" modified="2021-06-02" version="1">MRHHHLDVDVTGRQETARTRHGVEVVAPYPDSEVVRFCSAVPGRLRGNPHRCKPLPHAAFAGTGLVPDHVLHRATKGGFDAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY9</accession>
    <name>A0A7W7WVY9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="7" type="ORF">F4559_002357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019820">
        <property type="entry name" value="Sec-indep_translocase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01218">
        <property type="entry name" value="TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="35817" checksum="0A24378E7C1F06D9" modified="2021-06-02" version="1">MGTSPSRWSQRRERRKLTSRRGNPDGTMSLKEHLYELRRRLGIALAIIAVGAVFGFFWWGWHIFGLPSLGDVVIAPYCGIPESDRFSQGSCQLLQTKVFEGFMIQLKVGAAAGMAITAPLWLYQVWRFIAPGLYAKERRFALTFVGAASVLFVLGAALAFYIVPQGLVVLVGFGDSQFLTALSGGDYIDFVLALLLIFGVSFELPLIVVMLNQVGVVSYEKLAKWRRGIVFALFIFAAIATPGTDPISMVALAVALTLLFELAIQVARVHDRRAARRRKAEGLDDLDDDEAAPFDYTPTQIEEPEPPITPTQPRERVRYDDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVZ6</accession>
    <name>A0A7W7WVZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA (YjgF/YER057c/UK114 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11064" checksum="0361F2F3A5FB04D7" modified="2021-06-02" version="1">MFMAGQLGRDEHLNAVEDKEAQFAQAFENVGKVLGAAGVAFDDVVDMVTYHTDMRDLPLFIEVKDRHFTNPHRLPAWTALGVGALAMPGLLAEVKCTALPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW07</accession>
    <name>A0A7W7WW07_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035948">
        <property type="entry name" value="YwqG-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103032">
        <property type="entry name" value="SSF103032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="36870" checksum="A752CC2185D5A219" modified="2021-06-02" version="1">MGFTTPDKPVDVAALFPELAGLTRTAVRLYPRRGETTAQESSLGGPLLWPANEPWPVCGDDDHMADAGVPVPVVAAPLVSVAQFYSRDVPELPFPEGTDVCQVLWCPRGHEPYYTPRFRVLWRDSASVAEVAVAPEPDREHSDVDFLPNPCRIAPERVVEYPQLRELPSDGLRERIVAWEREQKWDYSEHLSAAPGTKVGGWMEWIQDPFRPDCARGHRMTPLLTVSDSEISGWETWMPMEVVSRIAFHKEVRFGLANGGTGRTWLGPDQELDPAVAGISGSRVVPESVVEVPVPDFSALPDELGVEFGGGNLYVFVCPTCPERPIEVEYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW15</accession>
    <name>A0A7W7WW15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator YbjK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20164" checksum="44F14B8DBC16D652" modified="2021-06-02" version="1">MDNRRDLLRDTAVSVLAEAGGRGLTHRAVDRAAGVPEGTTKNYFPSRDALLRAAAERLAEAHEAAVARLHTTTPADVSPAEVGALYPALLRRAVAEPAQLLAMVELYLEAVRRPGVRQALGRMAVANARAGARLHRAAGLPGGVRDAGLLDAFFLGVAVSLVALPADALREVGLDDGDELGAELFRAVVPGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW38</accession>
    <name>A0A7W7WW38_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restriction system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="78"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21736" checksum="89E8F3A91B41E662" modified="2021-06-02" version="1">MTTRPRKSRKPDWKPGLAVAVAAVIVLPPFFRSHPVLSVTVTTLVVLGATTWFALRLRAGRIEAERQAGRDRAIEVTDGMTGPEFEQWTARLLRRSGCRDVEVVGGTGDAGADVVAWTPGGKRVVVQCKRHVRKITSPDVQRFGGVFHYHRADVALLIATTTFTEPAQRIAAGVGILLVDRTALAEWARTNVPPLPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW60</accession>
    <name>A0A7W7WW60_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21237" checksum="C29B77B32E8C19A1" modified="2021-06-02" version="1">MRTSLAQRDSESSWTVAIAVGLPLARIGVECAVAGDRDFRVVASVGLAEELDPVGCPADLTVVEVAPHGPVPAPVVFGALVCHSRVVVLAHAGDPRVRELSGVGAVVGHDTEARDLVRALRVTAGDRLPRRELLSRREVETVRHIGQGLTHRQIARRMGLTEATVSTYVKRIRGKLNVTNKAELVLRAMAFGYLTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW78</accession>
    <name>A0A7W7WW78_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="43447" checksum="4543565FE9DA39AB" modified="2021-06-02" version="1">MVEPVILDPSGRDVQGEAAALRDSGPATPVVLPGGLGAWAVTRQETLKRLLADPAVSKDARQHWSAWRAGEVPDDWPLHLWVSVRNMFTAYGGEHRRLRALVARAFTARRTEASRPVVKAIADGLLDRLEAGPAEVDLRAGYAHPLPIEVICGLFGIPDAARSGLREAVDIVFDTTTTPEAAVANQHRLYALLHDLVEDKRRSPGDDLASGLIAVRDEDGGRLSEAELIDTLILVVAAGHETTVNLLDHAITALLTHPDQRRRVEAGEFTWGDVVEETLRWQAPVANLPLRYAVRDVAVGDETIARGEAILAGYAAAGRDPDVHGPTADAFDVTRADKSHLAFGYGVHHCLGAPLARLEATIALPALFARFPDLRLAVDETELVPVASFISNGHRELPVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ1</accession>
    <name>A0A7W7WWJ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12895" checksum="14E6B40F05805B6D" modified="2021-06-02" version="1">MHDISKQNGFCVDMHTKDATAAGETADRLHLVAAWREATVFTDAERAALALAEVGTRLADTHQGVSDETWAQAREHFDDDQLAALIGQIALINAANRMNVIVRNPAGSYRAGMFDAVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWN5</accession>
    <name>A0A7W7WWN5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="664" mass="72190" checksum="7B18D563A5566E8E" modified="2021-06-02" version="1">MTMDEVRNTAHGGDRLVQAGIVHGGVHFHAPRPVPPRQLPALPTSFAGRVDVLAALDDVVPLRTIAGVGGIGKTWLVLRWAHRRADRFPDGQLFVDLRGFTPGTEPTAPEAAVRGFLDALGVEPGRMPPGLDGKVALYRSLTADKRLLVVLDNAASADQVEPLLPGGGACVVLVTGRRVLRALVTRHGARHLALGVLTDAEARTALELRLGRPRLDTRPDDTARLIGLCRGHPLALAILAGRAHVDPGLSLGDLVTEVEAWDDDLTTVFATSCRALTAEQFRALHLLATAPGPDIGHEAAAALIGSCPTRTLTALREASLLDHADGRYTMHDLVRRHVADAEPVDLVASRRLLDHYLRTARAADHVLYPHRDRVDAPVPRPADADEALAWFDTEHANLLAAVRTAAGHGWHDVVWWLAWALDTFHFRRGHRVDRLTVWQAALDAATHLDDPASLIGAHRNVGIAHAVLRDPEAADTHLRLALASAERHGDLAQQARTHQMLAWAGQWRGDLRQALAHGERALALHDRLDQPVRRADTLNQVGWYETLLGIDATARFRAASELHRRHGNPDGEATALDGLGSLAFDRGRHRAAVEHYRRALALRRGLGHVYGEADILERLGHAHAALGEDGQADLAWREALTLHGVQGRDQDGQRVGRLLSRISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWS8</accession>
    <name>A0A7W7WWS8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-glucoside transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031349232" evidence="1">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="45316" checksum="7B4DF64D3011D388" modified="2021-06-02" version="1">MRNLVLVVLLVLSGCTAPGSTATVTILASWSGAEEAKFRRVLDAFEEQTGIEVDYIGTRALGQVLESEVQQGDPPDLVIFPSPGELATYAKRGYLHPLDDVLPGHREEYGDQWLELERAATDRQYGLAVKADLKGVIWFNPKELIEPKPARGAELQALVRRTRVTPWCVGMGASPYSGWPGTDWVETLLLRLSGPALYQDWTAGRLTWASSPVRAAWETWGALAGPDLVRGGARGALLTDFGDAGRGLFTDPPGCLLELQGTFAAGGYQGYETKPKAGIDYDFFEVPPFGEGRPAKAVAADLAAMFNDTPQARRLMAFLASASASAIWPGSGGAYSVNRRVPPAAYPDDVAKRVSGKLTEPGTFCFDASDLMPPTMRTAFHRAVLEYLADPGRLDEILANLDEVRAGVPPGEWLDFPCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA6</accession>
    <name>A0A7W7WXA6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31118" checksum="5612B1FF25E102C6" modified="2021-06-02" version="1">MLVLVAGSSGLIGNAVVADLRDAGHEVRRLVRRPAEADDEREWDPPGDVVAADALTGVDAVVNLCGSAIRGRWNAKDKRTVRDSRIHATHVLSKAMAAEGVPLLLNASSVSYYGNTGDVAVDESAGSGDGFLARMVIDWEGATAPAREAGVRVVTMRTGLVLSRDGGLLSQLRPMVRLGLGGKLGDGRQYVSWISVADVVAAIRFLLTDRGLSGPVNLCAPDPVTNAEFTRALGRALRRPVFMTMPKPVVRMAFGDAADELALNSLRVVPTALLDAGFRFRHREFAAALADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF5</accession>
    <name>A0A7W7WXF5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase A</fullName>
            <ecNumber evidence="3">3.4.22.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.70" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="276" mass="29223" checksum="DB128986FC1DF2F6" modified="2021-06-02" version="1">MRSPVTVVLLSLSLLLLNFAAYLLLVGPVRYERAQDVLYAQAREELAGIEMPFSGAIEPGRPVAVLSVPGLRITQVVVEGTAGAQLLDGPGHRRTSPLPGQAGVSVLMGRAVTFGAPFRDVTALRAGDEIVATTGQGRFTYRVDGVRRSGDPVPPSPGKGVGRLVLVTAEGGDVLGLPLRAERSVYVDATLLDVPVPAGPRPSLVGKEEDVLAHDSSGLVPLVLWLQVLLAAVVGVAWAAVRWGRWETWLVGFPVLLGASWQVYEHVAVVVMPNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH4</accession>
    <name>A0A7W7WXH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031338660" evidence="3">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="31205" checksum="E4A6000D90071BFA" modified="2021-06-02" version="1">MRLTALATALITATLTLTACGGSADEAASSPTCPDGKVRFGVEPFEDPERLTPAARVLADALSKSLNCPVELTVTEDYAAEVLAMENGKLDIGVFGPLGYVFASKRAKAEAVASFGEADGRLSSYTAGIWVPVGSDITGVDKLRGRSLALSSVGSTSGDALPRKALKDVGIAETDLKISYAGGHPEALLALTNGSVDAAEINSQQLASATAAGTFDKSRFRQVWTSAPIPNDPITVRGDLKPEFKTAVKDALLGLSPEAVKEIGALLDVDPPGRLVAVDRSTYQPLFDLAETLGLTEKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY91</accession>
    <name>A0A7W7WY91_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="30903" checksum="69261CE55DA1F897" modified="2021-06-02" version="1">MHTPEQPRNNPMVLVGVFSAVVLFVLGLGAVQDIRVPDPIPGRAVAAPGGALPAEAPGPRPVLRLGDHPLLVKAVSLPATACALPAFGLSDKELIAYYTAGVACMDEAWRPVLEQANLPFERPTLNATPELGGSPCGDAPAEGEAVAYYCGRNRAIYMPTGRMRDNGGGDRPGTHLATLAHEYGHHVQALSGMLRAADFKIGAAGEETPAGLEWSRRIELQANCFAGLFLYATSDALGPDLAREAAEDFQYAVEEPAEKNAHGLPDNQAEWAMNGFAAGTTGSCNTYTASAADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY97</accession>
    <name>A0A7W7WY97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="430" mass="46206" checksum="DCA807C625165BC0" modified="2021-06-02" version="1">MSDLPFGFGPQDPDDDRRKGDDQSGANPFDFGQLGAMLSQLGAMFSNAGSSAGPVNYDLAKQIALQQLSDSGPTIGFGPDQGSAVTDAVHLAEMWLDPVTSLPAGSRTTQTWTARDWVERTLPTWQRLCDPVARRVSGAWVDAMPAEAKEAAGPLLSMLGQMGGMAFGSQLGGALAQLGSEVLTSTEVGLPLGPEGTAALLPANIEKFTEGLERPASEVLVFLAAREAAHQRLFSHVPWLRQRLLDTVEAFAQGITVDTSALEQLAGQVDPANPASIEEAMKSGMLEPKTTPEQQAALARLETLLALVEGWVDVVVADAVGERLPGAEALRETLRRRRASGGPAEQTFATLVGLELRPRRHRAAAALWKLLGDKHGIEQRESVWEHPDLVPGSEDLDDPLEFVERFGSTRAALEDPIAELERTLKEERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD0</accession>
    <name>A0A7W7WYD0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14320" checksum="831A116565BAF1D4" modified="2021-06-02" version="1">MTASTALRALREALVLEHLESENEREFDTALGVFDHPRCEIVATGEVFDGTDEVAGYYARLGLVCADRRSTLIELHHADDAVIVEVELAGTHLPSLRAFRARMTAFFVFDGARLVGKRVYGGAQGTEPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH3</accession>
    <name>A0A7W7WYH3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10628" checksum="602A37CE461DEE19" modified="2021-06-02" version="1">MAELLTDDQVTNALSHLPGWIARNAALVRTAELSSFAQAIKVVDRVAEIAERDDHHPDIDIRWRTLTFRCATHSSGGITALDVSLAEEIDRVLAAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS9</accession>
    <name>A0A7W7WYS9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="1">2.8.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="14785" checksum="F4A23729BE49362F" modified="2021-06-02" version="1">MTEILLAAVGVEPLSVEEHAKLVEDRAAGAVVTFAGVVRDHDHGRSVASLEYVGHPSAADVVAEVVADVVAGRSGVRAVAVSHRVGPLAIGDVALACAVAAEHRGEAFAVCADLVDEVKRRLPVWKRQVFTDGTDEWVNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT2</accession>
    <name>A0A7W7WYT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="38368" checksum="BA015240ED6D7A7C" modified="2021-06-02" version="1">MNLEASGRRGSDFAELSRMVKAEGLLDRRVRFYVMCLVAAVGALALSVAAVVLVGDSWWQLGLAAVLAVVYTQIAFLGHDSGHRQAFAGRRANDTAGVLLGNLLIGVGYGWWIGKHNRHHANPNHEDEDPDVDIAVLAFSAEQAQRKRGFFRWVVSHQAALFFPLLLLEGFSLHVISTAAAARREVKGWRLELALLAVHFVAYFGIVFTVMSPGKALAFIAVHQGLFGVYMGCSFAPNHKGMPVLSAGHGLDFLRKQVLTSRNVTGGWFTDFLLGGLNYQIEHHLFPNMPRPHLRRAQVLVRDYCDRYSISYAECGLFTSYRYVLEHLHEAGSELRGTAKLAPSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT5</accession>
    <name>A0A7W7WYT5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">secF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="11" type="ORF">F4559_005417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="721" mass="74410" checksum="F640E1EF82F1DB8F" modified="2021-06-02" version="1">MPRSSARRELVVRGLLSLGVLAASAFLLLTSTPRLGLDLRGGTRLVLETPTEASSDATDRALEVLRRRVDELGVAEPVLARSGDHRIVVELPGVQDPAEAIAVLGRTAQLTVRPVTGPGDVPTPEGDGVALGEAVLTGDGIKDARESPNPDGVGRQVGVDFQGDAPGQWQQVTGAAACHQPGDPRRRVAFVLDDKVVSAPQVDPSVGCGTGMIGDSTRITGRFGQAEAAELALVIRSGALPVPVEVVEQRTVGPTLGAEAIEASSRAAVIGVLLTGAFLVFAYRLAGLVAVLALAGYAAVSYAALLLIGATLTLPGLAGFVLAIGMAVDANVLVFERAREEFARRRRLGRSVDQGFKGAVSAVADSNITTLLAAGLLFWLAVGPVKGFGVTLSIGVLASLFSALVLTRVLLTLIMPVLERKPAWSGLHSLGRVRTWLTARGIELYRRPSHWLVVAAAVVVIALGGLVVRGLDLGVEFTGGRMLDYTVTRVDVGAVRTGLAEAGFGDAVVAASGDDGVSVRLGPVDEAAAARVDDVVARASGGAEQVRDELIGPSLGSELRRDAVIALLIAVLAQLAYLAVRFDWRLGVATVAALVSDVVVLLGVFAWLGKTADGVFLAALLTVIGYSVNDSVVVFDRVRELTRPAGKGRTYASVVGTAVLQTVPRTVNTGIGVLFVLAALLVLGDGSLADFATALLVGLIAGTVSTVVTAAPVAIALGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU7</accession>
    <name>A0A7W7WYU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="11362" checksum="AB244A59799132B4" modified="2021-06-02" version="1">MTAVETDWRVVWAATLDLMEADVAAAEALLSHDRTVRALPPASFTAPAGMGPLPLELRPRADAVLARQLAVAEALVVAMAATAKQAAMLGRIEDAGQAPARPGYLDCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ64</accession>
    <name>A0A7W7WZ64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional repressor of lmrAB and yxaGH operons</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="19520" checksum="45E8F79F9BEDA49C" modified="2021-06-02" version="1">MPRRTDTRERMIRTAASLFRAQGYHATGLNQVLVEGGAPKGSLYFHFPGGKEQLAVEAVTLAGAAQCERLRAVLAETPDPVTALARALDVLAQDLVDSDFRDGCPISTVALDVGGDNEPIRVACADAYASWQRIIADHVGSESLAAVVLAALEGALLLARTQRDLAPLRALETHLAPLLGRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZD1</accession>
    <name>A0A7W7WZD1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc/manganese transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="27908" checksum="9B2D2A9F897C54C7" modified="2021-06-02" version="1">MFDLQLTGELLGYGFVQQMLVAGAVLGVVAGLLGPLVVTRRMAFAVHGTSELAFTGGAAALLVGVGVGYGALAGSVIAALLLGLLSRRDSDRDSVIGAILAFGLGLGVLFLALYKGRAANKFGLLTGQVVSVGSTDLWLLIGSSVAVLLVLAFIYRPLHFASVDVAVATARGVPVRTLSVVFAVLVGIATALSVQIVGALLVLSLMITPAAAAARVTASPLRASALAVVFAEVSVLGGMLLSLAPGVPVSAFVTAVSFLIYLVCRLVSRPAVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE2</accession>
    <name>A0A7W7WZE2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14101" checksum="E50E54FC72D91A4B" modified="2021-06-02" version="1">MDELPGGLSFDRSRAEAVRYYPERSAERRSGWVAGVFSGLAGAVLVLGLAVVGVDRLGDSRWFALGALGLAGLVLGLLCLGRLSPAAPLVAGVVLLIAAGVSEVRHEWVSVQLKVVFASGVPVGLGVLLVVVGAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZI3</accession>
    <name>A0A7W7WZI3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="50952" checksum="67C138A84BBBF1F3" modified="2021-06-02" version="1">MHNHSDIATGDALVARLVALEPTRAKRTEAYEALYRHARAVVVDQAGAVWLATMAAHPDHWVRTIAVRTLGSGRDPAAQPILVRALSDPDVSVVEAALEGLTPQSSDTVFDLLVTLLDKTDRSRLWVVRHAARRIAESSDPRRLDILADTLGDVHYGTEHDIAEALIRAGDPRVVPALIGHLHHRRPGRFAAAKVLGELRVVEATGPLVEVLRESDGTQALPVVEALGKLKALEAAPAIVPLLGHASPHVRECALSALNRIGGPLVASAALEATDDVHPDVRAQAVRVLARHGDHRAVGRLAAACDGPHVHAALTGLARLPDDSIVPTAERVLQTTDERRVRKLAGRILARAGRPPSLFGRHPDPVVRRAVVWVLGHHADSNRLWSLTNALKDEDEIVRSRAAAALGRITHEKTLPPLTEALRDPRPRVRANAATALGRTAPEGLRSLLADALVDPHPAVRSAASAALRATNRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXQ8</accession>
    <name>A0A7W7SXQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate ferredoxin oxidoreductase subunit alpha</fullName>
            <ecNumber evidence="5">1.2.7.11</ecNumber>
            <ecNumber evidence="5">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="5"/>
    <dbReference type="EC" id="1.2.7.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="266"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="4">
        <location>
            <begin position="524"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="628" mass="67181" checksum="BD04842BD388C80D" modified="2021-06-02" version="1">MTTDVGNAVPGGTEVRKLDRVVIRFAGDSGDGMQLTGDRFTSEAAAFGNDLATLPNFPAEIRAPQGTLPGVSSFQLHFADYDILTPGDRPDVLVAMNPAALKANIGDLPHGGMLIVNTDEFTKRNLVKVGYETDPLEDDSLEAYQVHKVAMATLTIGALENTGLGKKDAERAKNMFALGLLSWMYHRPTEGTERFLREKFAKKPDIAEANVLAFRAGWNYGETTESFAVTYEVAPAKLDVGTYRQITGNTATAYGIVAAGQQSGLPVVLGTYPITPASDILHELSKHKHFGITTLQAEDEIAGIGAALGASYGGALGVTSTSGPGIALKSETIGLAVMTELPLVVIDVQRGGPSTGLPTKTEQADLLQAMFGRNGESPVPIVAPRSPADCFDAALDAVRIALKYRTPVLLLSDGAIANGSEPWLIPDVDKLPDLRTPFATEPNAPDGSGEFWPYLRDPETLARAWAVPGTAGLQHRIGGLEKADGHGNISYDPANHDHMVRLRQRKIDGIEVPDVEVDDPSGEARVLVVGWGSSYGPIGAAARRVRKLGMPVAHAHLRHLNPFPRNLGDVLSRYERVIVPEMNLGQLALLLRARYLVDAVSYTKVQGLPFKAEELQDVLADVIKGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXR5</accession>
    <name>A0A7W7SXR5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ORF">F4559_000264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="19793" checksum="24CE9996F37DFA30" modified="2021-06-02" version="1">MRLVLVGPPGAGKGTQAGLLKSKLGVPHISTGDLFRAHIGEQTDLGREVQQYLDSGRLVPDEVTNEMVRARLAEPDAAAGFLLDGFPRNVAQAGVLDEILASGGHKLDAVVEFRIDEELVVERLLARGRTDDKEDVIRHRQEVYRTETAPLLDHYSGILVTVDAVGGIDEISERALAALRGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY20</accession>
    <name>A0A7W7SY20_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FO synthase</fullName>
            <ecNumber evidence="9">2.5.1.147</ecNumber>
            <ecNumber evidence="8">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">F4559_000395</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 5'-deoxyadenosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin + H(+) + L-methionine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the radical SAM superfamily. CofH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the radical SAM superfamily. CofG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="9"/>
    <dbReference type="EC" id="4.3.1.32" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="72"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="525"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="829"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBB4963036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="844" mass="91433" checksum="3D8C365304A6D444" modified="2021-06-02" version="1">MAVDISITPPESQPSPAAMRRALRRAADGAVLDLTEASVLLHARGDDLDALLAAAGRVRDAHLLAEGRPGVVTYSRNAFIPLTRLCRDRCHYCTFATVPHRLPAAFLERDEVLEIARAAAAAGCKEALFTLGDRPEERWPQAREWLEARGYSSTLDYVRACAIAVLEETGLLPHLNPGVLSWEEFQRLRPVAASMGMMLETTAERLWSEQGGPHYGSPDKEPAVRLRVLTDAGRVNVPFTTGVLIGIGETLTERADSLLAMRGIARQYGHIQEVIIQNFRAKPDTAMRGMPDADLRDLAATIAVARLVMPSSTSVQAPPNLVGDEYGLMLRAGIDDWGGVSPVTPDHVNPERPWPQVDVLTEATAAAGFELRERLAVYPRYVRATAGQWIDTRLTTHVAALASADGLAVPDAPVVGREWQEPDGGLDTYGRADLHASIDTEGRTDDRRSDFDSVYGDWSSLSVPAAVSRLPEDTARALRLAADAPERLLADTDASMALLTADGEALETMARLADDLRRDVVGDDVTYVVNRNINFSNVCYVGCRFCAFAQRERDADAFRLSVDEVADRAREAWDAGATEVCMQGGIDPKLPVTYYADVVRAIKARVPGMHVHAFSPMEIVSAAAKAGVSVREWLADLAAAGLDTIPGTAAEILDDDVRWVLTKGKLPAATWLEVVETAHTLGIRSSSTMMYGHVDHPGHWLGHFRTLAALQDRTGGLTEFVGLPFVHRNAPIYLAGVARPGPTRRDNRAIHAFARLALHGRVSNVQVSWVKLGDEGTAEVLRGGANDLGGTLMEETISRMAGSEHGSNRTVAQLHATAALAGRPARERTTTYATPTRESSTQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG9</accession>
    <name>A0A7W7SYG9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8212" checksum="B48B0C8334C179EF" modified="2021-06-02" version="1">MQAIVGDLLHIHSRKAGLAEQVGEIIEVRGSAGSPPYLVRFDDGHEGLVYPGPDSLVRHPEDLPRQVRRDSSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYL4</accession>
    <name>A0A7W7SYL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031138552" evidence="1">
        <location>
            <begin position="27"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38749" checksum="71AF168534602C9B" modified="2021-06-02" version="1">MRGTRSLVVAATAGLAVAGAVVPASADTQSGRIDRGIVQQSLDRMAADGALGVQVRIGDRGHEFTARSGKAQLDRPDPVPLNGRFRAGSITKTFVSTVVLQLVGEGKIVLDVPVARYLPGLLPDGDRITVRQLLQHTSGLYNYTNALPRDPAGQLAIRYKHWEPEEVIALATAHPLDFEPGTSWNYSNTNYAVAGLVIRKVTGRTWGEEVKRRVLYPLGLTGTSVPGDQVTIPGPHAHGYVGAGDQVVDITELNASVAGAAGQLISTTADLGRFIDALVGGRLLKPAQQAELLKTTEASPEYGLGVDVFTLDCGTTVIGHNGGIAGYLTTMYTSSDRKAKLLASVNTAPRPGELDGEQDLFDEVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP5</accession>
    <name>A0A7W7SYP5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10846" checksum="1E844DD41FB64FAF" modified="2021-06-02" version="1">MTEPRSLTETRSRIDTVDSALIRLLADRQELVRTAAAFKKDEQDVRAPDRVAEVIALARSRAEEAGLSPDVAESVWRAMITAFVDLELAEHSALRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ9</accession>
    <name>A0A7W7SYQ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="33803" checksum="21B6BEBD98C0A575" modified="2021-06-02" version="1">MDAALAGGHEVTTFRRGLTGDDAPGVEVVRGDRTDVDDLARLAAGGPWDVVVDTSGYVPREVGAVARALSPVVGRYVFVSSVSAYVGWPVEPLTETSELLDCPADAAGDYGHDGDPGPSVYGFTKVGCERAVTDAFGADRVTILRPGVILGPREYVGRLPWWLNRVARGGRVLAPGSPDRPIQPVDVRDVAEFALAAPTGVFNVTAPGTETFGDFLAACVSVACAGEPHWVPDEFLVAQGLRQWTEIPLWRTYAGAWAVDSSRARAAGLRTRPLIETVRDTWAWMGTKRAVEHERAGQLGIDPEKEAAVLDAWQAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU3</accession>
    <name>A0A7W7SYU3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32677" checksum="C69E626158EACF91" modified="2021-06-02" version="1">MDVDTRVLRYFVAVAEHLSFTRAAELLFVSQPALSRQIRQLEADLKITLFERTSREVRLTSAGAALLPPARALIADWQAAQRTARSVAAMESRVLRVGFEATGAGPLTTRARTTFAARHPDVTIEPKRFDWGGEVAALRDGLVDAAFLWLPADTTGLHTEIVAVERRLVGFAATHPLAARAEVGIMDLRDDPLMWTRKAPRHWVDWWAVNPRPDGSEPVWGPENDNVEEMLEHVAAGAAVCIGPESMAAYYARPDLVWRPIVDIPPLRIALARPANSTNPLVVAFAEVVRELSEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU4</accession>
    <name>A0A7W7SYU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Csd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010144">
        <property type="entry name" value="CRISPR-assoc_prot_Csd1-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09709">
        <property type="entry name" value="Cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01863">
        <property type="entry name" value="cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="588" mass="65283" checksum="C011FF79BF716F18" modified="2021-06-02" version="1">MLVRRLVDHAASDPDSKPFHRRLRFDWELALTADGAAPGGLQRLMETDAAGRSRGVEHLVPTTVRTVGVAPNLAADDVQYVLGWSDADTKPDRVARCHEAFVDLTLRWADSPEAQGDPVPQALARFYRDGHAEAMPRVAEAGAKQRVLITVKGEAAYRARSVQAFWSAEVASRKGSGGRRGLCLSCGVNGPLLDTLPGKVPAKLVPGASNDAALVSINERVFGYDLNDKLICSPLCVSCGEQLTAGLTRVLASRDTASYGGQDSRLAWWITKPVRRDPMRVMVEADPAQVRELLNDVRKGRPSNRTRRRDSEQKSDMTKFCALTVGGNVARVMVRDWLESPLEKIEDNAATWFEQAHVMVLHPDESEWHSLTRLVRVTGRWQRDRRQYVPIGAKGADRPDGVQRDLLIAAMRGTRLPHSLTIHLLNRVRTDGHLDTPRAALLRLALLRSPSTTEKPMPGLDETNTNSAYVAGRLFAALDAIQYDAFEGKVNATYSRRHFQGAVTNPRAALIAGRKLADAWLRKFRGTRVGTAVNHSRELDRLYGLLGPDSDVPYHATPEQQSLFLLGYHHQRAHRFETVRRRAEERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYY2</accession>
    <name>A0A7W7SYY2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28521" checksum="405B6C9C366C0049" modified="2021-06-02" version="1">MTALRRSSRAPRPASSTTDPSMPTAADRLPKNDRDRRLTLAGQAAGRDRVRRRTAVTRSAGSGPTWCRPGAWRWCAAPVPGRRPRQEVLVTPPPCTNTTARPAPTGATNVPASIRPSRVRTEAATPSTDTTAPFDQVAPWFHDRRLEDRRVRHGAQRASVRRRPGLRVLCVSAARVARRHVLPNRCTRPHPVSVHRSHRTWNPGGRARASTPRTPAVVRSAHAYPPRLGRSGRLGSESARCVVSGAVPWLDPCHRRGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ16</accession>
    <name>A0A7W7SZ16_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">F4559_000942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="32936" checksum="470AAF6D04CA7D7A" modified="2021-06-02" version="1">MAAQIRELRTRIRSVNSTKKITKAYELIATSRLAKAQGRVEASRPYTEEITRVLTELATASSNLDHPLLTERKNPKRAGVIVVTSDKGMCGGYNANVLKEAEQLIALLRSEGKEPVLYVVGRKGVGYYRFRQRTIAGEWTGFSQLPHYVNAVETGDTVVNAFVEGTDNGGQGVDELHVVYTEFHSMLTQTPVARRIAPMDVEYDATPQKVRSVYSFEPSAETLLGALLPKYVKTRLFSALLDAAASESAARRTAMKAATDNASELVRNLSRQANAARQAQITQEISEIVGGASALTGGAGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ36</accession>
    <name>A0A7W7SZ36_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="9954" checksum="EA900E3BB451B4D9" modified="2021-06-02" version="1">MSERTAASRHLPFGLVLAVVVLGLVRIGQYYWREGVVLIGLALLIAAVLRLLVSDEQAGLIAVRGRGIDALLYSGLGIAVIVVAMTIIGGPFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ77</accession>
    <name>A0A7W7SZ77_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Electron transfer flavoprotein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="7">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="32333" checksum="60338F810C893DFF" modified="2021-06-02" version="1">MSEILVLVDHVDGDVKKVTHELLSAARRLGDPAAVVVGAPGVTAKLKESLAVHGATKVYVAESDAATEYVVTPKVDALAAAVAAASPGAVLVPATAEGKEVAGRLAARLGSGLLYDVVDLDGEGVATQSIFGGSYAVKSRVTTGVPVLALRPGAVEPVEAPAEATEVVVDVPAVDPAKNARVVGREPLVGGGRPDLSEASVVVSGGRGVGSAEKFDVVEKLADSLGGAVGASRAAVDSGYYPHQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDSEAPIFEIADFGVVGDLFSVAPQLTEEVDKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ95</accession>
    <name>A0A7W7SZ95_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23066" checksum="81E88CFF291B15AC" modified="2021-06-02" version="1">MSISVLLVDDHEIVRRGLQQLLAVEADITVVGEADTAASAVTAAAEHRPDVAVIDVRLPDGDGVTVCREIRSVVDPPPACLMLTSYSDDEALFGAIMAGAAGYMLKQVSGNDLVSAIRTLAAGGSLLHSGVTATVLQRLRGGPVEDPRYAALSPQERRILDLIAEGLTNRQIAHRLYLAEKTVKNYVSSLLHKLGFDRRTEAGVYAAKRRQRGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF6</accession>
    <name>A0A7W7SZF6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="47281" checksum="7AD413F39D62CA60" modified="2021-06-02" version="1">MRTANDRLRAARERTESPVNPGECLSRQELAELVNAHVWRQHGTTVEIDANYVGKLERGVIRWPGPLYREALRAVLGAPTDAALGFGNRRRAVVKLSTVDRKQFLRTAALGVGSLALAPVTALLEGNEPTPVPARIGRTEIEQVHTAARVFAGWDHTYGGGLTREAVLAQLRFSAGLLETAYPARLHGPLHSAVGYLAHTCGFMAFDGYAHDDARRVFGFALACAEEADDWHLRAKILSSMARQAIWLGKPDEGLTLTEHALVRADRLTPTERAMLHTAHARALAKMGRVRDTLVAVGTADDHFAHAAPAEDPPWMAYYDTAQHHGDTGHALFDLAVGGRSADKATARLASAVAGHTDAFARSRTMSRIKLATLTMATDDPREAAAIGSSALDAAGALRSRRAADDLRELARYGLRHRTTPEVGLLRHRITAAVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG6</accession>
    <name>A0A7W7SZG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methylcytosine-specific restriction endonuclease McrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="120" mass="13093" checksum="EA4F370E910BF040" modified="2021-06-02" version="1">MPQRAGKRCPTPGCTNPTGPDGYCAERCARRRNAAAHRTTPTKVARASREVRRHRAEAVRAHLDQHDDGMGHCPGYGREPHDVFPGELTADDPVPIARGGDPLQQMAVLCRSCNSRKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM0</accession>
    <name>A0A7W7SZM0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_000626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="9">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="38555" checksum="7A04937554071B01" modified="2021-06-02" version="1">MRISVPREIKNHEYRVALTPAGTHELTNRGHEVFVEAGAGLGSAITDEEYVAAGAKVLASADDVWAEGDLVLKVKEPIAVEYPRLRKGQVLFTYLHLAADLPLTKALIDSGTTAVAYETVQTPNGALPLLAPMSEVAGRLAPQVGAFALMKPSGGRGVLPGGVPGVHPARVVVIGGGVAGLNAATIAVGLGADVEILDTNVDRLRHIDALFQGRLRTVTSNSYSIEQAVRDADLVIGAVLVPGAKAPKLVSNELVSQLKPGTVLVDIAIDQGGCFADSRPTTHADPTYAVHDSVFYCVANMPGAVPRTSTYALTNVTLPYAVALADKGWQTALRADRSLALGLNAHEGLLTNEPVAQAHDLEFTAYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY2</accession>
    <name>A0A7W7SZY2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ORF">F4559_001299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18403" checksum="2B8A4BFAD34FE852" modified="2021-06-02" version="1">MDVVVGRVAKAHGITGELAVDVRTDSPDTRFAEGSVLNAKLRDGTSRDLTVTAARHHAGRLLVRFEEVVTRDVAETLRGTLLLGSTADLPPTGDPDEFYDHELEGLNVELLDGTVIGTVREIVHGPGGELLVVRREGGADALVPFVREIVPTVDVTARRVVLDPPEGLLDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0B5</accession>
    <name>A0A7W7T0B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5305" checksum="5A33218EE8AF2FAF" modified="2021-06-02" version="1">MSRAAPPHRYSLVGCVRESEEVDLVVAQCPDEGDRDEPVTEALTFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G8</accession>
    <name>A0A7W7T0G8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="20" type="ORF">F4559_001673</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="89"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="493"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="17">
        <location>
            <begin position="711"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="707"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MBB4964314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="756" mass="85289" checksum="B29762F1127E0974" modified="2021-06-02" version="1">MVHQLRLLRRELRQLLRLLRLQLLTGGDRKLSDPRRTVVPVAFPTEIPVKAHSSHRPVGDIPRTDGRFRVVSEYQPAGDQPAAIAELEKRVRAGERDVVLLGATGTGKSATTAWLVEKVQRPTLVMAPNKTLAAQLANELKEFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKDSSINEDVERLRHSATMSLLTRRDVIVVASVSCIYGLGTPQSYLDRSIHLEVGGEIDRDTFLRALVDVQYARNDIAFNRGTFRVRGDTVEIIPAYEELAVRVEFFGDEIDKLYYLHPLTGDVVREVEELRIFPATHYVAGPDRMEKAIRGIEAELADQLALMERQGKLLEAQRLRMRTAYDIEMMRQVGFCSGIENYSRHIDDRAAGTAPATLIDYFPDDFLLVIDESHVTVPQIGGMFEGDASRKRNLVEHGFRLPSALDNRPLTWEEFADRIGQTVYLSATPGPYEMGQAGGEFVEQVIRPTGLVDPEVVVKPTEGQIDDLVHEIRVRAERDERVLVTTLTKKMAEDLTDYLLELGIRVRYLHSEVDTLRRVELLRQLRLGEFDVLIGINLLREGLDLPEVSLVAILDADKEGFLRSATSLIQTIGRAARNVSGEVHMYADRITDSMRHAIEETNRRREKQVAYNTERGLDPQPLRKKITDILEQVYAEAEDAIEPGGSGRNASRGKKPAGEPGGRSSGVLVDRDTSRMARSELADLVQQLTDQMMNAARELQFELAARLRDEIQDLKKELRGMDAAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J0</accession>
    <name>A0A7W7T0J0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="631" mass="65704" checksum="1B210E11A6D73B73" modified="2021-06-02" version="1">MTSLRMAFNELRRITSGKLPRLAVLALVLVPLLYASLYLYANKDPYSHLGQVPAALVVEDKGATKSDGSAFDAGGQVADELVSGAKFRWERVAADAAERGVRDGTYTFALTLPADFSKSLLSSADFTPRQGVITLTTNDANNYLGSTIANQVVAEVRRSVSARVGSAAADQLLLGFSTIRRETAEAADGATKLADGQRQALDGVTALADGLVPLSDGAGRLSSGLTQLRSGTAELPTQTRRLADGAKQVADGDEVVAATAADYAAKAQELTTKLDQSDGAVAVRLRELGFTDEQIQGVLGALGQARETVDGANAEVQRTSGQLRQLADGARQVSDGAALLAANTPALSEAVATLDDGAGSLSSGLVTARDGAVRLKDGQQQLLDGTTRLRDGLAEGVARIPSPDDPTRESTATTIGDPVAVHGVSQTAAGSYGGGLAPFFLGLATWIGAFVLFLLLKPLSRRALAARQMPVRIAVGGWLPGALLGMAQVVVMYSAVTLVVGIRPVHGVTTLAFLLLTSATFVAILHALNALLGAVGKFVGLVLLILQLVSAGGTFPWQTIPVPLYPLHYGLPMGYAVDGLRHLMYGGDLDGVGRDALILLCYLVGALALSTFAAYKQRVWTPSRLAPELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0P7</accession>
    <name>A0A7W7T0P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001495</name>
        <name evidence="3" type="ORF">F4559_003061</name>
        <name evidence="4" type="ORF">F4559_003920</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="20120" checksum="9818A948E9588971" modified="2021-06-02" version="1">MARFDLTDAEWALIEPHMPVAATGPLPRRVREQFNGILWRFRTGSGWRDVPERYGPWSTVYSRFNTWAKTGVFQTLMEALIAEAASRGQVDLELVSVDSTIVRAHHESAGLAVTGETLDALEQALTEEKGAPLPVQRSVLRVVRRGPRRTRPTRAHLPVGTVPPVGAVGRRGLRRPGSAGPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S2</accession>
    <name>A0A7W7T0S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11715" checksum="AA39B8731846B872" modified="2021-06-02" version="1">MPVIPDSTKNSLAQRLRAHAKDNWPQLADVHARYHGQFAYVTGELTDGERLPLVRLRYGGSAHRWGSAIYVASTNSYENQIWFTGSTEEVFDLVCDLHVTNAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T1</accession>
    <name>A0A7W7T0T1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MoaA/NifB/PqqE/SkfB family radical SAM enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="34471" checksum="5EC7A77330A39688" modified="2021-06-02" version="1">MHPTRLCNLRCLHCYSSSGPDVAESIPIGVLDQVVHDAAALGYDVLNVSGGEPFLYPELPALLRAARDAGMGTTVTTNAVALNQRRIGLIRGLVDLVAVSLDGDQPTHDRIRDRIGSFDKALAGIRRLTEAGVPVGVVTTLTQGNATQLGDVAEAASASGALLLQVHPLEPEGAANRLMAGERPDAVELAYAAVELGRIAAEHGMAVQLDAVPRTTLSRTPEAFMAAPTAGPLGRWLTPLVVEANGAAVPVSYGFDRRYSLGNVHDRPLSDLAAQWDPEPFRELCRTTWERLVEGRTGPLVPWYGHLVRASRTAVIEPSTPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X5</accession>
    <name>A0A7W7T0X5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <shortName evidence="6">IPP isomerase</shortName>
            <ecNumber evidence="3 6">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">IPP:DMAPP isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">idi</name>
        <name evidence="9" type="ORF">F4559_001903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="3 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00202">
        <property type="entry name" value="Idi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR018427-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21235" checksum="3BF75E29AFCD0C77" modified="2021-06-02" version="1">MEQVVLLDEQGAAIGVADKVGVHHEDTPLHLAFSSYLFDRSGRLLLTRRALHKKTWPGVWTNSCCGHPAPGEDAASAVRRRLREELGLGDVTLDLVLPRFRYRAVMDNGIVENEMCPVFRGYVDTEPDPNPDEVDSVEWVDWAEFVPAVLSGVRPISPWCRLQVEELAKLDDDPTRWPVGVESDLPPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z8</accession>
    <name>A0A7W7T0Z8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10836" checksum="D4254BCD48FD93E2" modified="2021-06-02" version="1">MEVEPHLDLGAVSTPGSRDELVEAITELARMASRWSDVVGNLYEPTRRLVGTAAAASVSLAARRAEEAFLELEMTLGDVRAARRSLPLATSRGEDDRPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T182</accession>
    <name>A0A7W7T182_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="41436" checksum="D3AE0EC18A35100E" modified="2021-06-02" version="1">MAVTTENQHGLAEHSHGAGAPVSSRADHFASFDVEAFEIPGGREEIWRFTPLKRLRDLHAGAAATGRAAVEVKAAEGVVVETVAKGDARLGVAGTPGDRVAAQAWTSTTEATVVTLPGDAKVEPTTVTITGPGVDGVAYGHVQIHAKRFAEGVVVLDHRGSGAYADNVEFVVEDGAHLTVVAIQDWADDAVHVSAHHAKLGRDATFKHTVVSLGGDVVRITPVVTYAGRGGDAELLGLYFADAGQHLEHRPFIDHAVANCRSNVVYKGALQGEDARTVWIGDVLIRAAAEGTETFELNRNLVLTDGARADSVPNLEIETGEIEGAGHASATGRFDDEQLFYLQARGIPQEQARRLVVRGFFHELLLKISVPEVRERLEAAIEAELEAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G3</accession>
    <name>A0A7W7T1G3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Feruloyl esterase</fullName>
            <ecNumber evidence="7">3.1.1.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="PTHR33938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031545957" evidence="6">
        <location>
            <begin position="24"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="539" mass="58025" checksum="7DB86B47D4B0303E" modified="2021-06-02" version="1">MRRLLLCLSVLALLVGGTVTATAEPSDTGRPVVDCGSLVRDYDLPGTRAHVTSATPVTDGIAHCDVRGHVDDKVRFQLRLPTAGYSGRYVQYGCGGLCGELYAPEFPERCGPRPGDAAVASTDDGHVGTGATPFFDATWAANDQKARDDWQFRAPHVTSLASKAVIKAFYGAGPRQSYFTGCSNGGQEALLLAQRYPHDFDGIVSAAPGAYFGALVLYEAWLTRVNTDAAGGSVLTAPKLPVLHEAVLARCDGIDGLVDRQLDDPRRCDFDPGTLRCATGDAPTCLTDAQVDTARKLYAGPTDAAGVRLYPGNEAYGSELAWYGWIVPAPEYGEAFARTLADNYLRYAGYPIGTPHSSVDAVPFTQAELRRIGVEGARGNAMSLDLSEFRRSGGKLVLWHGWNDQAIPADSTLDYYERLTRTSGGPAATRRWARLFAVPAMYHCFGGTTLTEFDPLKELFSWVEQDRAPERVVATGRDGDGNVVRTRPVFPYPLTARYDGSGSTDEAANFVPALPAKRPKDAIDWAGTYLHHVPGPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y6</accession>
    <name>A0A7W7T1Y6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031507000" evidence="2">
        <location>
            <begin position="34"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="698" mass="75332" checksum="151F775DFF8C4EC2" modified="2021-06-02" version="1">MTTSRSRRKWLAALLVPLAGAATALLPAAPAAGAHSAHPHHGHIRGQVKLPTPPAPPRLARLTGSVTPKAAAPLAATDKVALRPLVIALDKDDFGLPTWKTVLGRIGSPYDVLYAKTEQLTAGRLVLPDGTGRYNAILLTDNALLYPDGSGNYVSGLDAAEWQALWAYESTYKVRQASLYTSYGTFPEDYCLRAGEEGGGAFTAKLTTAGAQVFDYLKADAQIPITDSYVYRTTVAAGCSAQPLLTVGDRVLGVTSTSTDGRERAGLTFSSHESLQQVGLLGYGLVRWATRGVFSGELRHWINVDVDDWFNSSDHLYPDGHVETDPGFRLTGPEVSGIDNQQKSLRTQFPAAAGFTLNLPYNGGDLDPEAPSQCSTSNTSDSLTSYSLCLKRNFRWVNHTLTHPEMNFTSAAVNRQEISENLEVGRDAGLTVPTEILKTPAYSGLGVYNPDPNAPDTDPPTDFGLAKSNKALLDAAYGLGVRYVHGNMSFTSHQPSCFNCGIYHPLRKEILVVPDWPTNIGYQATAPAEQALFYNQLYGPNGRIPQFPRNLTYAEQLEYESNVTLSHLTSGSAYAHTLHQGNLRQYSVGKSLTFDWLQLVVAKYTAKFKVPLRNPDWPALSTYVKARNAHFSETAAGRDPVWDKSTGKVTYTAATTGSLFLTGVTGVTGTVDRYGSDNIVQIPVKAGGAITGTATPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T235</accession>
    <name>A0A7W7T235_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="87"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="41872" checksum="165953DEE60B93A0" modified="2021-06-02" version="1">MSIVLLEFLSFGLGRLAEAAEALDEELVLFTAHRPLYAHELATVPPDRVRVVDIDTTDTAKCEAAARDLPDLRGLISSTDTWAAPGADLAARLGLPGPDPAAVRVLRDKAAVRARLYEHGLSRGVAVPPHEAASLGFPLVVKDSAGTSSRAVWVVRDDAELAEVLARAADVPLKGDLLAEPYFAGPLYSAETITWEGRTRLLGVTSRHLSPEPLRREENSSFPVVLPQDEHGALVDWISRVLAAAGHGRGFAHTEFVWTVDGPEVVEINARIGGALVGEALCTALATNVYTALVEVALGREPDLLTAPLGTGPAVAFQALYPTTTGVLDGWTGLDRLAGLPGSPRWFPTTTPGAVVEHLEDQRGCTGIVLVEGPTAELALHRAAAAGNVIGHTVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2G4</accession>
    <name>A0A7W7T2G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032030">
        <property type="entry name" value="YscD_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16697">
        <property type="entry name" value="Yop-YscD_cpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="608"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="943"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="626"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="961"/>
            <end position="968"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1397" mass="145816" checksum="E19ECA80EFA85BD1" modified="2021-06-02" version="1">MSVVLRFSVRADRAGDGSDVELAAAPGTAVGELLDRLDARGRPCYVGSTRLDPTARLAEVPLVPGAVLTVGAPGPVARAVPDDAAGDAVVVLTATAGPDSGLVVPLAPGRHVVARASGAAVPLRDTDVSRGGHARLDVSSAGLITVTDLGSTNGTYVNGVRVTTPVVLAPRAVLQVGSDELAWAPASASARRRIAPDRRVEFDRVFTATPEIPELVLTLPTPRTTDDGTTSTAWIGLLAGAASVAFAIGTGRAWPLVFGLIGLLGYLAIRENEQKRRKKAESTQDRERRAAVAELATHLDAEARARAALAPGPAEIADAATGASPHLWPRRADLPHGLELRLGHADLPASVRLSGTPWPDFPAAVLRAAPVTVDLRATGVLGVVGPHRDGCLRWLLVQLAVLRGPDDLRLVVITADDGHGLAWTRWLPHVDGGDAGVPCLIGNTPDTRAARIAELRGLIAHRRADRVPAGAEVVVVLDGASTLRELPGLADVLRTGPAVGVRVVCVDRHAVNECAAVLDTGDVARLLGVGDPLPLTPDVLDPATADRLARALAPMRDRLARASSREAVPAHARFLDLVGIGMPTADDVLRGWVGRGPRTAVPLGADESGVVSVDLARQGPHTMLGGATGAGKSILLQTLVTSLLLANRPDELNLLLVDFKGGSAFLPFEHCPHVVALVRSTGETAADVFDEAAAARVLTSIRAEVGRRESLLARYDGEIDRYWARRAADPGLPPLPRLVMVFDEFARVLESSPDFLRELVNVAAKGRSLGMHLVLATQSLQGKLSPELKNNVSLRISLRQNEPSDSVEVLDVPDAATLPGSLRGRGLIVCTTAESRLPHTFQTGYLGDPPPDGGTPDAVVRVLGWTEVGTPRPAVARPADNRATDQALVLSAIEEAGRRLDLPAPFRPLWPALPADLGADDLDGPVPATAVPFGLLDDPAAQARPTDFLDLAGTDRLLVAGGPQSGRTTFARAFVAALATRFGPDQAHVYVVERHPSGLTDLGDLPHCGGVFGPGDPERLRRLITWLAAETGRRATAGRRGPHVVVVIDGWELLEDHSDPAYTPTSLVTTLHDVVAKGAPLGVHVVAIGGLDMLNHRLPALYSRRLLLPFPKEETRRAHLTATTASPPAVPGRAVDAATGRHVQFCRPPAVVVPRTAESGAPRRFPPLPTRVDAAVPADRPSPTWIPLGVGGPDAAPLGVDLFGGTRGVLLVSGPEGSGRSTTAASVARSLSAVGVPVLALASPRSPLGGTRDPGVHVLTGAGLPDTELRAAAADLGPRYAVVVDDADQMSVVPTQEGFTDAPTLLDDLANPAVRGDRVLVLTADAAPLATGFPGPRARLVLGALTTGVRLVLCPTDRATALAHNLHLEPDQYLDGPPGRGYLATARTAVPIQVAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U1</accession>
    <name>A0A7W7T2U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="46" mass="5251" checksum="B17F8D7C0835ED94" modified="2021-06-02" version="1">MSGSKDVDRLIEDRFRRHPQAEVIIKWALPRNGRPCRPARPLAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T351</accession>
    <name>A0A7W7T351_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_TE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="PKS_thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_TE" evidence="1">
        <location>
            <begin position="104"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="31317" checksum="D1DCAB79AAC70CF7" modified="2021-06-02" version="1">MRRLVLASRRGPATPGAAGLVEELTAAGAEVVVAECDVADRRSLARLVAHRRFTAVVRAAGVLDDGVLTSLSPERVDAVLRPKVDAAWHLHELLPDVAVFVLISSLSGVLGGAGQANYAAANTFLDALAHHRAAAGLPALSLASGPWAGAGIGTLSDRKWPDLFDAAVRTGEPVVLRDTYVPGEITPRFSRAMARRTFEKLDAFTDLRDVGLTAMGGYFGMFTGWTPTPIGVPTLFVRTADPVGDAEDLPWTDDWRPGWTLADAFVEVPGDHFSMMDDHAPTTARAVSDWLAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E3</accession>
    <name>A0A7W7T3E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tellurite resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13268" checksum="F15C56A0A46DEA1E" modified="2021-06-02" version="1">MNGFTEDEGRTLRTAVYGAMVLVSVADEGAVDEESHAGIRAMSALPPQLRQVVGAAPPELPVGTVADVEHGVLTALRASADLLAARSAGQARAFADAVLAMCGDVASADGTVGRAEDVVVARIRSALDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3F0</accession>
    <name>A0A7W7T3F0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase PrpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="33974" checksum="474C7B367E525B3D" modified="2021-06-02" version="1">MIMDCCPECAAPVSAQDRFCEACGRNLRVRRTPVGGPDSPAATRCACGGTEFDRDAFCTRCGLARGGGRDRVEFTLPGVAGVSDRGRRRRRNEDSMAFGRVRGRGVAAVVCDGVASSERAEQASQTAVDTALDVLLTAMQSGGDAERSTADAVVAADAAVARLARPEAPELAPSCTYVSVVATEDSATVGWVGDSRAYLVAQAGAACLTSDDTWAAQLVAQGVLTEEEALTDRRAHVLSRWLGADSGTDAPRTVTFRVEVSGLLVLCSDGLWNYLPEPEDLLEVLPRGVTPVEVARELVEVALKSGGHDNVTVVVVQLRGGHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L9</accession>
    <name>A0A7W7T3L9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase of the HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22740" checksum="543F7E92B253BB52" modified="2021-06-02" version="1">MGDGRQVDAVLVDWGGVLTVPVPAFVDDWLRVDRIDRERYHVTMSDWLHSGSGPVADLETGVLSVAEFEHLLAAELVTLDGGQVHAPGLLTRMFGTAHTDPAMVGLVRDLRAAGVHTVLLSNSWGEDGYPVTLLTELFDTLVISARVGLRKPDRAIFDHTLDLVGLPADRCVFVDDMPANVDAARALGLHAHRHTTADDTRAALARLGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M8</accession>
    <name>A0A7W7T3M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009351">
        <property type="entry name" value="YcaQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06224">
        <property type="entry name" value="HTH_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="385" mass="41750" checksum="C22C1958EEEB67D5" modified="2021-06-02" version="1">MTTLARITDHDRRARLGPRHLLAHPADTVEQVADAVVGLHATDAATVYLSACARLADPSIKAVEDAFYERATLTRLLCMRRTMFAFTTGAAPVVDAAAARGIAAKERAGLLKYLAEGVGWDAARLAEVERLTLDALRDRGEATAAELSAAVPALREQVLVAPGKKYETKQNVSSRVLRVLAADGRIRRSRPRGTWLSTQFRWTPADPRPALDVAAAQAELVRRWLAAYGPGTEADVKWWTGWTLTAVRKALTAIGAEPVALDHGTGFVLPGDVDSPDSPPWVALLPSLDATAMGWQGRDFYLDPGHKPKLFDAYGNIGPTVWADGRIVGAWAQRPDGEIAWTTFADVGTETTAAITDHAHRLADLLGDTRFVPKFRTPLEKDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N1</accession>
    <name>A0A7W7T3N1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator YbjK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="19932" checksum="D588C41DC08A1ECC" modified="2021-06-02" version="1">MDTPPRARRARDPGQRRREIVAAAVDLITESGPAALTHRLVADRAGVSPGSVTAYFATLDDLRTAALESMAGLLDEEITRIGTALAATDDVVGVVVDWTHAYLSDSRLVRSDVAVATAAVADDDLLVLTRRWFDGMVAVLTPHVGAARAVAVTVFLDGATWHALHQGRPMDRASLAASLAALTGREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T9</accession>
    <name>A0A7W7T3T9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="379" mass="41027" checksum="F148B9A56DEE1BAF" modified="2021-06-02" version="1">MQDAFSNQLRRLRHERGLSLSELSNLVHYSRGHLSKVENGHSPAKPELVEKCDQVLRAGGALVALTPIPTRRGTPTPGHSMHADDITLAAHHEMFAAYRTLGHRTSPTVVLAGLVPQARALRAMAESNREPELTDALWLLAARYLEYGGWMAQEAGDDDAAIRLTDEAVRCAERGGDRELAAYSLVRQAEFAMYRNDSVRTVQLAKRAQAARGVSNAVRSLAAQREAQGYALAGEEVLFGRALDRAAELNRDVPSGPPAFGTTSVADPVAVARAWSTYHLGRPARAAELLAEQVPLIRADAVRSRARFGLRLALSHADAGDLDHGSTLALGLLDDVRGVDSATIRSDLTAFVRVLEKSGPLPADALLLRTRIREVLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3X9</accession>
    <name>A0A7W7T3X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type multidrug transport system fused ATPase/permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10578" checksum="B2DEB63A0C075D2C" modified="2021-06-02" version="1">MGRVVDLPGFADLPWDRPVGEGGSELSGGQRQRVASARALVADRDVLVLHDPPTSGDSVTEAAPARAVRRLRHGRTTLLLCSSPALLAVADRVVAVEDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z4</accession>
    <name>A0A7W7T3Z4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="30615" checksum="ACDD233895DCEF7C" modified="2021-06-02" version="1">MDRLETRELAYFLAVADELHFGRAATHLGITQPALSKTIRRLERRLGVGLFERTSRAVTLTEAGRVLAREARTALDAVSAATERTRRAGTRDPRLILAMKPGGDAGLLPAILAAYEREPDVLPIEVVFGGNRARMLREGQADAALLYTPPDDVRGLDTETLLSEAPVAVLPVSHPLAHRVGLHVADLAGENLHKHNPADAGAIGSISELMHLIALGRTVAVLPQSLTTPLRDDLTTVPVTDIPPSVLLLAWPAHSTSPSVAALPRATTKAVFAEDIALSAVESPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T494</accession>
    <name>A0A7W7T494_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="773" mass="85976" checksum="27CB5EB717175BC8" modified="2021-06-02" version="1">MTRHQARVSSELIEALWKVLDEDEFDEEIDRLKLNPADVVTKVSRTPSVVEQAYELSAPVATADADVERHRRDKPEWWPLDWQPTKVERRSLIVAPAAFLGWIGLLAVFGGSMPDLVFVGVTALVLAICYVCAMIGLPTEFVDGIRWAVRLAFLTADGVGERWDLRQKLRDEVVRPELRKWLSSQTTPSFDVVLELRNADSLSLPAGEGPLVETPAVQACEREVNRRLPGAVGLAGTRGVGKSTIIRNALDNKFTHERRQPMLGVLTSAPVRYDARDFVLHLHACVCRAVLDLLADRDDRSGSETRRLWKREYARRLTRARIARVLGNVLRWAVRTLFALGFAGLAWGRTGDVRVVVREATAFAADLVPNVRAGLSAGDLRVVAALLTLWFALRAAWSLWLFTGWPLLAWLVSSLRRRLKRTPGPRRHGPPIEALHKVAEQHLRTIRFLQTHTSGWSGKVSAPIGTEAGWSKSLAKTEQPWTHPEVVDRLRDFLALVVDVLVDGHGVLSGVTIAIDEVDKIGDPEEAQRFLNEIKGVFGVRHCLFLVSMSDDALTAFERRGIPARDAFDSAFTTMIDVRPFTLDESRDWLARRALGIPEPFVWLCHCLSGGLPRDLGRTAIALHDAHKRQKGPWHLADAARLLVRRDLDLKIRAFTHTARQVARDTAETTGRLRDLLESLRQAASADVDDLLPIAEAMRRGADGDPTPITELSAEAACYLLFCQTVVDLFGQEVDQESGTGAVAIGIADARRWMADETTLAWNHLVGLRTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4H5</accession>
    <name>A0A7W7T4H5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="30688" checksum="48E1DD22B00AA99F" modified="2021-06-02" version="1">MNNAPLDVDHLADRFADVAESIAEGVGGTPTLGEFLEVVGWSVPSDLPYPFEVAATVNGRRYVPADASRVPELADDVFADARSALADLPADPDAVAEVLTLVLAAGRVPLADLDPARLRRLTPVTKRAARPKPGDLLAIPVSDGYRVAVVITRNRFGTALGLFDGVTSDGRAHARVLAAPRRFPVYTEESLVKSGRWRVVGHDEGLLALFPDSPEVYHEPGSPVTGEFGAAESADGRLRLVDRDEAVAAGLSAGGLGAGTYRQTMPGARLQTVLTDESALTDESGPTDESGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W9</accession>
    <name>A0A7W7T4W9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="12940" checksum="B38818D714E39E70" modified="2021-06-02" version="1">MIPVLPTVLTVLALLAAAWAVALAVLDHPITLATRPSQGLALAVVALELGLVGQLVAGVVAVIGTDRELETGTFVGYLVGAAVVLPLGAFWSLAERSRWGAGVLAVACLSVPVMVLRLSQLWTPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T555</accession>
    <name>A0A7W7T555_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="15018" checksum="265306EC67147C79" modified="2021-06-02" version="1">MEFIVPFGVSLFDERRPLKDAPGAYAVHRACGPVEARFEVTTWDRHVSVLSSFYRWVVAEGYAAAEPFTYAQAKTLYGDQFRDRRINLAIRRRPKAHVTIKYLEEDFEALFLKALAGLTPEGEEDTGYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T590</accession>
    <name>A0A7W7T590_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FMN phosphatase YigB (HAD superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23608" checksum="5537E67FA24B3A2A" modified="2021-06-02" version="1">MVTAVVLDVGETLLDDSREWGAWADWIGVPRHTFSAVLGAVTAAGRDNAETFQYFKPGFDLARERRRREEAGLGEHIEDSDLYPDVRPGLARLRELGLWVGVAGNQTARAAELLRALGLPVDQVATSGEWGVAKPSLEFFTRVAEMVPDGPDETVYVGDHRDNDVVAAKAAGFRTALIRRGPWGYLWADDPLVRRDADWVIDSLHDLPNLLAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A8</accession>
    <name>A0A7W7T6A8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Salicylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019996">
        <property type="entry name" value="Salicylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03494">
        <property type="entry name" value="salicyl_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="174"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="444" mass="47779" checksum="3D1AE7DAEC9C1F48" modified="2021-06-02" version="1">MSTHYFETQVPLTADPVTVATRLAASGLHDSYVVYETGGTWAYAGGVRAELTLDRTGAVLKQENAPDTVLPWSDKPLHQVSRLLDAVTIPGWRAYGWATFELSYAKDGDLDHVSANRLLHLIVPKAEVRIIAGAAHLRAADQRTMTDLIDTVTADTVSEENTPRPLDVRGLGVDQYQRSVQLAVDSINAGDLHKVILSRVVDVDYDVDLVATYQVGREGNNPARSFLLDLGGIEATGFSPEIVVKVSADGRVVSQPLAGTRALTPDLVVNEKLRNDLFGSAKEVYEHAISVKVGTDELTDVCRPGSIEVPEFMAIKERGTCQHLASQVAGLLADGFATWDAFGAVFPAVTASGVPKVAAYEAIRNFEAESRGLYSGAVLTVDHTGEMDAALVLRSAYRQDGRTWLRAGAGIVGQSTPEREYEETCEKLDSVARYLVPASGGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I3</accession>
    <name>A0A7W7T6I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5131" checksum="C4532DF3E0704CC4" modified="2021-06-02" version="1">MPACPRGSVGADDLAGLQHLLEPAQVVAELLVRLLAEVLDEAAEVGHQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M5</accession>
    <name>A0A7W7T6M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein YphA (DoxX/SURF4 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14659" checksum="3571C64E5BCF5044" modified="2021-06-02" version="1">MREEVRLADRVAMPALRVSLGLVFVWFGLLKVVGETPIAALLEASVPWVDPDLLVPGLGWFEVVLGVALVVGRYLRAVLAAMGAHLLGTFIVFVQAPGMAFAGGNPLLLTVNGEFVLKNLVLLCAVLVLFAEHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6U0</accession>
    <name>A0A7W7T6U0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="431" mass="43676" checksum="01F6DE5791C55EF9" modified="2021-06-02" version="1">MTIPIERTRWGAVVAVALGVVLAALDLTVVGVALPVLGTELHAGPTVTQWVLHAYNLALVALAVPAGRWLDRACPRSAFLLAVGGFGVASVLITVAPDAPLLLAARAVQGVFAGLLGALTIPLVAAVSRPEHRGRAMSLVLALFPVSGVAGPAVGGLLTDAFGWRAVFAINVPLVVLAFVVGRRTIPAKGGLPAPGRRSLVEASVVGVGATALFLGGYWLPLAAVALVIWLRLPQVRPVRTMLRTRASASSLFALPLVVTGIAAVNFVVPYLLAHRSATVAGLVLLSTSAGMAAFSPVGGVLADRFGAARVAFAGAVVVLVGTVALLPLDESAAPWDVAWRLFVLGIGHGLFAGPNSAAILAATPPDLIGTSGGVSTLLRTLGFSLGPALAAAATGFGTVVVALIAVTAAGCIVQVWSQRVRDLPKRPVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6U3</accession>
    <name>A0A7W7T6U3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23576" checksum="18BDB7DA089532A4" modified="2021-06-02" version="1">MDVLLDNLDLYGPGFLDTVELFLLSGTGALVLGVVLAMLRVSPVPVLRAAGATYVTIVRNTPLTLVFFFFAFAFPLLGIVNTRDFGSYYFVAAVIALTLYTAAFVCEVMRAGINTVPVGQAEASRALGLTFGQMLGSVVLPQALRAVVPPMVSTLNALLKNTTIAAGFSVFQAGSISLNLAERGEDQLVGLAWVALFFVVLVIPMTLLQRSLEKRWSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6V8</accession>
    <name>A0A7W7T6V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="12541" checksum="2AA2C53E09FBCA88" modified="2021-06-02" version="1">MSRTAHPRTVEGSRPWRSIVVVDLRYDHACFAEARGERPRPRLIRRRVAVHRFPRGRNDSDVRDRAQVQERRARRRLRRELYLARVAGLEDVVPARHRRDALYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X1</accession>
    <name>A0A7W7T6X1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dapF</name>
        <name evidence="10" type="ORF">F4559_005019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28246" checksum="11B0F6A55CB2853C" modified="2021-06-02" version="1">MGVEFLKGHGTENDFVVLPDPDGLLDLTEERVRVLCDRQGGLGGDGVLRVIRLDMGPWFMDYRNADGSIAEMCGNGVRVFARYLVDAGLVPRGEFTVSTRGGNRDVVVHDDGTVTVDMGRALVTGTSTATIGGTAFDGVCVDVGNPHLACVTGTPVTDLDLALPPGHDPVAFPHGVNVEFVNVLDDGALRMRVHERGVGETRSCGTGTVAAVASWLYGRGERTGKATVDVPGGQVSVVVDEETSTLTGPAVLVARGELDQAWWDSLGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T701</accession>
    <name>A0A7W7T701_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cytochrome bc1 complex cytochrome c subunit</fullName>
            <ecNumber evidence="3 10">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_005092</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 2 heme groups covalently per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009152">
        <property type="entry name" value="bc1_cytC-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000007">
        <property type="entry name" value="Ubiq_cycred_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031335288" description="Cytochrome bc1 complex cytochrome c subunit" evidence="14">
        <location>
            <begin position="48"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="15">
        <location>
            <begin position="52"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="15">
        <location>
            <begin position="148"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="11">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000007-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4967733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28256" checksum="67D77DD382FEE1D5" modified="2021-06-02" version="1">MTTITTRARKRSKLRRRISGLLALGFALLSAGFLFSALAPQPQTAQATEDPAQVRLGEQLYNNTCISCHGANLDGVEDRGPSLIGVGEAAVYFQVSSGRMPMARQEAQAQRKPAAFSPEEIEALGAFIQSRGGGPETPEERGEALRGEDPARGGELFRLNCAACHNFTGRGGALSSGKFAPELDGVTEEQLYTAMLTGPQNMPKFSDRQLTPEEKKDIIAYIKSVTDGNNNPGGAPLGGLGPVSEGLIAFIVGIAALIGVTLWIGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T784</accession>
    <name>A0A7W7T784_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">F4559_005218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="7"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="52800" checksum="B7AF5436366E993A" modified="2021-06-02" version="1">MAADRIDTVVSLCKRRGFVYPCGEIYGGTRSAWDYGPLGVELKDNIKRQWWNFMVRGREDVVGLDSSVILPREVWTASGHVEAFVDPLIECNSCHKRFRQDTLVEEYAERTGKEVAEGDVSDVPCPHCGTRGQFTEPKMFNGLLKTHLGPVETEEGLHYLRPETAQGIFTNFLNVQTTSRRKPPFGIGQIGKSFRNEITPGNFIFRTREFEQMEMEFFVEPGTDEEWHQYWIDERTRWYTELGIAKENLRHYEHPKEKLSHYAKRTVDIEYRFRFGGQEWGELEGIANRTDFDLTTHSNHSGVDLSYFDQATNSRYKPFVIEPAAGVGRPMMAFLLEAYVEDEAPNAKGGVDKRVVLKLDRRLAPVKAAVLPLSRNAELSPKAKDLATALRRHWNIEFDDAGAIGRRYRRQDEIGTPFCVTVDFDSLTDHAVTVRERDTMAQERVSMDQLESYLAARLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7D6</accession>
    <name>A0A7W7T7D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Virginiamycin B lyase</fullName>
            <ecNumber evidence="2">4.2.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031366738" evidence="1">
        <location>
            <begin position="32"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="39977" checksum="661068C6FFC03DD7" modified="2021-06-02" version="1">MRRAKSLRHKHFRLAVLLALVAALVPGTASAATPIVEYGPVPSALPVGGVCEVEFDDTGALWIEQYLSGQVARFDPVSGTFANFSTPMPLSVPGGMDVAGDGLWLPQVTGNSLLRVDTTDGSMTEHLLPWANAFSLTALDIPLHTGLGLANDLAVGPDGALWFTLGGLDSIGRYDPATGEWGRYRVPGEILGQLGALFGIIKPGPGRTVLFNLPQLNKVATIDVDTKAFTQYTMPTPASYPVGVRTAGDGTIWVGESLGMKIANIDPVTGRIVEYPLSGLGGILNSVLAGLGIGSVGNPLPMAGPIAEAADGRIYFSVSFPAAFGLGNQIARFDPTTRQVRMWPTPSSASYPCDVNVTSPDAVWFGLLTPNRIGKLPLSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7D7</accession>
    <name>A0A7W7T7D7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase D</fullName>
            <ecNumber evidence="2">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23744" checksum="BD0B1E1EFE9B9335" modified="2021-06-02" version="1">MYRKFSYGPNIEVFILDMRTYKDANTSPRDQAGHILGDRQARWLLDSLSRSRAMWKIIAADLPIGLTVPDGADIEGVANGLPGAPGGRETEIAWLLKELKRRRVRNTVWLTADVHYSAAHHYSPDRATFQDFDPFWEFVSGPLHAGAFGPNTLDPTFGPQAVFVSAPPAANTTPLDGFQHFGEVEVAADGRLTVWLRDIKGRSLWSTTLDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7R5</accession>
    <name>A0A7W7T7R5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="259"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="407"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="506" mass="55193" checksum="74F88ACF9BDF283A" modified="2021-06-02" version="1">MTDPNLPAAPEYREDDDRAGWHRLDVRMLVVRPLNELLGLIPLLVGLLVLGNGDVWRTVVSGVVIAAVVLFGLLHWLTTRYRITDEQVELRTGLLVRKRLAVPRDRIRSVDLTAKPGHRLFGLSAIKVGTGRQDKPGEDGLTLDAVTSAEAERLRLLLLERRAPDTTADTAVAGTTLSTLDKRWLRFAPLTLSGLVAVGALAGVVFNAARDVDVDLMKPLTDAAIRLAHEPATTSVPLIAGAVVTLSTIGSLVFYVVQYWNFRLTREPDRTIRVRRGLVTTRSVSISEDRLRGVEIREPLMLRWGRGARTAAVTTGLGTKGASDLLLPPAPAPEAHRVAAEVLRAERSPTEAPLSPHPTAALRRRMVRALVPPVILTGVLAWSAPSWTWQAALALTAFCAYLGWDRYRALGHALSDGYLVTRSGSLLRETAALHQSGVIGWRIRRSYFQRRAGLATISATTAAGDGEYHVVDVAERDGLTFAATAVPDLLRPFLIEDDQNDQATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T842</accession>
    <name>A0A7W7T842_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24472" checksum="49A3862FDE9EB527" modified="2021-06-02" version="1">MSTAARVLVIEDAEAIGAAVGSALREAGYQVQLRADGRELESDLARFRPDLVVLDVMLPGRDGFALLEVVRRTTGAGVVMLTARDGVADRLRGLDRGADDYVVKPFVLAELVARVSAVLRRLGRTPSTVQIGDLVVDADSAVVLRGDAPVELTATELRLLRYLAVQRGRVVGKTQILTAVWGYEDYDPNLVEVHVSALRRKLEEHGPRLLHTVRGLGYVLRAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T844</accession>
    <name>A0A7W7T844_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR02678 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013494">
        <property type="entry name" value="CHP02678"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09661">
        <property type="entry name" value="DUF2398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02678">
        <property type="entry name" value="TIGR02678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="41534" checksum="0D88B1F13A2A5482" modified="2021-06-02" version="1">MDGLPDLDARDVVRCARTLLRRPLLRADGPEGELLSLVYRHRVALTELFARHLGYRLVVERRFARLHKAGPGHDGTRGVAGLSPRGYAYLAVTLAVLTGIGRQALLSRLVADIRAAAAEAGVGVVDDIADRRALTAALRHLVSLGVLKETEGSVEVGAEALITVDTDLLGQLVTGPVADAESADGLVELAARPGPRGVEHAVRRRLVEDPVVLHADLPAEASAWLREHQRPESALLEAEFGLYTECRVEGVLAADPEEYLSDLAFPGTSTVARMALLALPCLLEGDGGPDGRHPVDRTRLVEVCAGLVRDHPTAWSRKVVADLDELADEVMELLRRVGVAVVGPDGVSLNPVAHRWLPEPDGVPGPEAERPVPEEPHWSLFDEENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P1</accession>
    <name>A0A7W7T8P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative serine protease PepD</fullName>
            <ecNumber evidence="5">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="535"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="631" mass="61598" checksum="6504B42B2D6E2DCA" modified="2021-06-02" version="1">MTENEPQRPESNPSSDGSDPGRDRPEWTDRNSGADAVQGGVAPAAGATVPRDPGSRDVVQGDAAGPDRSAAPGAWQGAPARPAENSSSGRSPAASGSGVAAPGSTRPADFSTQEVESGPTATHGLPGASTGSTVGGGSATGHPAADAFGGEGSSSGGSPEAEGASPGVGHPSGGSFASGSSAGGVDRGPSVGTGHPSGPGGDQGAAGGPYGNADGQAATTAFGTYGQAAPHGAAASPWERPSTDSGAWAQQGFPRHPYQGVPGQPQSFGAPVPRAPRSRGRVAAGVAALVLVVGGLAGGIGGYVGYQAANDRTSAVSNALDAAPPVRQSGNTAEGTIESVARKVLPTVVQVQLSGGTGSGFVISSDGLVLTNNHVVESAASGGAIKVQFQDGKIADARIVGRDPSSDLAVIKVQGVSGLPTAELGSSGDLKVGQQVVAVGSPFDLAGTVTSGIVSSLDRPVRAGGEQGSQATVLNAVQTDAAINPGNSGGPLVDMNGRVIGINSAIYSPNSSQTSQGGSVGIGFAIPIDQARRTAKELSETGKATQTVLGVQVTDVQEGGAQVREVSGGGAAEQAGVKAGDVITKFGDRPIDTSDALVAAVRSRAPGDKVKLTIGDKTVEVTLGSQPVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Q2</accession>
    <name>A0A7W7T8Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24051" checksum="6E7D7C7E047DEF39" modified="2021-06-02" version="1">MTSEFPSGKPLFSLLEGTRVSAGRHRLTVHGRWADIDVEDDSPLVREALYRMSLGPVSLEHIPVLFAEYNRWLADGFCGPEWPRLKLALDGLGGCVVPSLGLHDGAGPTLSLVAVVGHAEFHWPSIDDKECVELLPGTRIGEYDGERALLRRGAPYAVVLHRAPADRIAELLANGPTTVVELADRLGVDRPLVADVVAYLASAGVLYATDQFPPGGDPPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X5</accession>
    <name>A0A7W7T8X5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="22210" checksum="0E9662EC229674E3" modified="2021-06-02" version="1">MPLTVGFDLDMTLIDPRAGMAAVMDAVAAESGYPLDGAHFAANLGPPLDLVYRDQGVPEVDIPALVARFRALYPEIVIPSTVALPGAADALAAVRELGARTVVVTGKYRVNAALHLAAFDWRVDHLVGEVWSTGKGEALRTFGAAVYVGDHVGDVRGAKAADAVSVGVVSGPCTARELADEGADVVLADLTAFPEWLRANADRLSAVGNRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T959</accession>
    <name>A0A7W7T959_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17004" checksum="D481BECC34685FF0" modified="2021-06-02" version="1">MFEASDALLAWLYAQQGVDAVKAAMGARMEEIGCSLVEHEALYRIDRSGRLPMSGLSELLAVTPSGVTRLIERLVGRGWVVRVQLPENRRVVYAELTPSGRAFLKSTTGPAYRAAVAEEFTAALTDRDVADLRRIGRKLLEAHDRWDTERFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B0</accession>
    <name>A0A7W7T9B0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="104"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30906" checksum="88400871C6F256C5" modified="2021-06-02" version="1">MAIGSTRGKRRLGRFIRPLVDRSGMKVEDVIRETKVSRQTIFRMLSGDGLARWPSVSVVLDVVGASPEERTKALQLWEVADVDPSGVEHARDLPAGYLRFRLDELEAVRERSLDPVFVPGLLQTAGYAEALARAAGRRVGDGAWSARAAAERLERQKVLTGDRPLEYEALVDQAALLRMVGGREVMREQLRHLAAVTARPNVTIRVLPLAVGAYGAQSGGVHLLDFAEEDEPQAGYVEGFTGLVPVEDAVVGVLSAVWGDAARLALTADDSRELVESTLSSSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G7</accession>
    <name>A0A7W7T9G7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative tRNA adenosine deaminase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17714" checksum="1F27804911A6A0A0" modified="2021-06-02" version="1">MADQEPVNGFAVAVVREDGRWRCTRMEGSALAELDAAITELRRLRSTGAVFGLLAVDDEFFVILRPVPGGVSLLLSDAAAALDYDIAADVLDLLRVDPPDEDDEELWPEGDLAVLADVGMPKHELQVIVDEVDLYPDEQLQMIAQRCGFGEEFTALLDTIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V1</accession>
    <name>A0A7W7T9V1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7099" checksum="CEB3BFA02BE70D54" modified="2021-06-02" version="1">MTISQVPDQSSYDAPTVRTKPVTVPTPAPAPVQPQTPPAEAPRKRKSTLRRLARRIVGPTILTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA64</accession>
    <name>A0A7W7TA64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="24521" checksum="23AC016444597D46" modified="2021-06-02" version="1">MYIDEPGGTEGELKVTVEDEEYTVEIGYDLDHDGVDESAVVELDDGGHVAFSDVDHDGDADVMTRFDRAGEVVGQARFDEESGEWISTKPAAEDEKTNTNAGKSIIVETEDGNRDVGPATKDTDGDGRADTAAVVDEDGDLWLFTDADGDGVADVATEFAADGEVTMSKHVDGGEWVEVEHGRLDEHGKIVPDTDDLASDVAWGTSGEQKVTVSGVVRIDSVTGQWISPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAE9</accession>
    <name>A0A7W7TAE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="41466" checksum="7700C5D836E2DF8A" modified="2021-06-02" version="1">MKTGVADRIARFRDQYWERGEPGRETPAVLTSGLYRLWLLGLLLKLIGSSWDVAWHFKWLRDELAPPHMINTVGTVIVVGLTIFHTFTGYGVDRTSLRLMQWGTGIFLVALPIDLINHRINGLDITSWSGSHALLYLGTAIMLAGAIRGWLRYFPADRWRVPGLAALWFFFFENAWFPNQHQEYGILEIASWDRGDPYAEPSLLQFAADQIGRPVDRASIVRFSLPIADWVYPVWGLIAAAAVLVIARRTIALPWAATAVAAAYVGYRCLIWPLLAGIDFPISAIPLFLILIGAAVDAAHLGRVPALPAAILGAAATTGLGYGGIWLQQQLNAAPPVSYPSAAATFLILATTWIALDALLRRKAARRHSPVTTTPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG2</accession>
    <name>A0A7W7TAG2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polar amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031261480" evidence="2">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="4">
        <location>
            <begin position="48"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="29738" checksum="16726714C560CC52" modified="2021-06-02" version="1">MRAPLLIAAAALLAAACAPADEAGPPSQTLVNGLPCTKDKLATLTAGKITFGTDQPAYAPWFVDDDPSNGKGFESAIAYAVAGELGYAKEEVVWTRVPFNAAIQPGKKTYDADINQFSMTEERRQAVDFSASYYEVAQAAVTLKTGKAAGVKTLADLAQYKIGAQVGTTSFDAATRIVPSQQVAVYNTNDDAKAALTAGQIDVLLLDLPTALYVTSAELTDAAILGQVPGGQGRREHFGIVLDKNSPLTGCVSMALDTLRGKGKLKEIEQQWLAAQGTAPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH6</accession>
    <name>A0A7W7TAH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase-like glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26582" checksum="F6965379266BB5D1" modified="2021-06-02" version="1">MTRVLVVQPDETDPPARLGDWLADAGADPVVLRPYAGDPVPDTLDGYRALVCLGGVMGALDDVAFPWLADLRRLLSHAVAKRVPVLAVCLGAQLLAVATGGQVRRGVNGSEIGLGLVAKRDVAKDDVLFAELPWTPDVLQFHQDEIALLPPTAELLASSPAYANQAFRVGPAAYGLQFHIETTADIVLDWVVRSPGLAASVPPSRFDPERLARGHEDIEEVWRPFVERFVRFASGAITSRRELPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBL9</accession>
    <name>A0A7W7TBL9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine kinase-like BadF-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="30739" checksum="C5DB53CD2AAB198A" modified="2021-06-02" version="1">MGFVVGLDAGGTATRALVFDLDGTRLGAGVAGGANPHSHPPERAARHVGEALRMALDGLDAGKVESGVLGMAGSSRLGDPEVEALFTAAWNSAGLRCPMRVITDCEAAFASGSAAPDGTVLVAGTGSISARIVDHRLVSAGGGYGWLLGDEGSAFWIGREAVRATLREVARPGPLARAVLAHAGVTSGDRRRALIVAANAGAPVRLAEFAPLVTANAHDPVADDIIASAVEHLVDLALADRGRDELTPLVLIGSLVHATAIGPRLRRALATRTSAPIHVASGAAAGAAWLAAVSLLGESAPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT60</accession>
    <name>A0A7W7WT60_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11461" checksum="5A3A6D5815DE9625" modified="2021-06-02" version="1">MGYRVTGPEPLSRLCVKHLRGADRVVVAFPSVDTAWVLLVGRHDDDPGRNLYDALYELAGVAPRLDERRTKPPCCADGVPPLADADLVDDLVAKARALGKARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT65</accession>
    <name>A0A7W7WT65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system sensor histidine kinase SenX3</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="152"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="41401" checksum="7F9376F7A95AC535" modified="2021-06-02" version="1">MTATGYLVLSIGALLIGGGAFLAGRATARPRTERPAGLTVADLMGMVVQSAHDGIVVLNGFGDVVLHNPRAADLGVVRNNRVDDRARRAAELARETHEVVPVDLSSLEVKGRQPEAVHAQVKVLVDGFVVVHASDESDAVRLEATRRDFVANVSHELKTPVGALALLAEAVLDASDDQEEVRRFSAKIMQEATRLGTLVTELIALSRLQGAEKLPELNRVDVDVVISEALGRSRLAAEAVDIEITTDDPSGLGVEGDRTLLVTALSNLLDNAVAYSPPGSPVSVSRREVAGFVEIAVTDRGIGIAEDQQTRVFERFYRVDKARSRANGGTGLGLAIVKHIAANHGGEVKLWSLPGTGSTFTLRIPAHQTGEGHTADPSPSELATTRLGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV0</accession>
    <name>A0A7W7WTV0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="29737" checksum="D2B8994AD4A82628" modified="2021-06-02" version="1">MPPEWAHYAVGRAEQALRWLDHRVTTSPFAHDWARTALLRETRASAHLDGVHLALIEVFHHVLSTSPVGQWREPAFARHLATTLALLDTPTPTPAPEPLADVLTRHVRTPPAEGHARRLALPGALVRAGWLTRPWLPLSTHYTGTPDPTRPRRADVLAAVGRIADAITRTCHAEIALLDTLTRLHDHPAATRTRNLRAVWTDLLTRGAVTVTDLATRHGFTTKTGYNTTAALRALGLARVDPRPYGRTIHNPDVLDLLTCPHGAALEDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV8</accession>
    <name>A0A7W7WTV8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031795">
        <property type="entry name" value="Zf-HC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16827">
        <property type="entry name" value="zf-HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11526" checksum="ADDA8D3DBD2A4F97" modified="2021-06-02" version="1">MAVDPRDFRWLPHDGNRHAIPYTLSSGETGSTLCGLAVTVPRRSPPQFPDGCWPTCETCDASWRRHEGIPLFSERRTVNGRRPTLLKRPPTTVVIITHVLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTY2</accession>
    <name>A0A7W7WTY2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16234" checksum="5AAD1F8EC944C43A" modified="2021-06-02" version="1">MTTSVELATVEDTEEFGRRLGGVVGGGDLLLLSGPLGAGKTALVRGLASGLGVLGRVSSPTFVIARVHSPAPGGRSVSLVHVDAYRLGDLDELDDLDLDTDLVDAVVAVEWGEGAARLSDDHLLIELERRDDDVRVAHLHPHGTWVDRVSAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG3</accession>
    <name>A0A7W7WUG3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26826" checksum="4E0D41E45A228456" modified="2021-06-02" version="1">MTSPTRLVWGLAGHPEPTGAVANLFADRPGMCVMCGLSADRTADAARATGANFTDQYLYRRPDSDRICPACVWCCSGKPPATLRMWTVVAAIGATLPDNHPKCWLPSQPGLCLTNRAAPGVVADILAAPPEGAWLVTVATSGQKHVLPYGKVNHGGPEWTVRMENTTITSNAPTWRRVLGHAATLRAARHTGDDLAAGRPTLAAIRTADDLDTWNHHHAGLADHVGSPLLDLALWCLTKETIHDHAHAAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK1</accession>
    <name>A0A7W7WUK1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="26518" checksum="FD9F838F7B657300" modified="2021-06-02" version="1">MSALVSDVGTRTAVAAANLVKVYGKGDTAVRALDGVDVAFQSGRFTAIMGPSGSGKSTLMHCLAGLDTVDGGQVRVGGTEITSLGDKELTRLRRDRVGFVFQAFNLLPTLTAEQNILLGLELAGRKPDRDWFRTIVDVLGLRQRLKHKPSELSGGQQQRVACARALVARPDVVFADEPTGNLDSRSGAEVLDFLRMSVRKLGQTIIMVTHDPVAASYADRVVLLADGRLAGDIADPTADSVLAALKHLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM7</accession>
    <name>A0A7W7WUM7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="120" mass="12279" checksum="47290F0621384D8E" modified="2021-06-02" version="1">MSSWPQRTALAIAVVLLGWGLLDAVGVLGGAVLAVLHLTTGVLLGASTAGRRVLRRVAVLVGSAYLVVTAFGVSDRPYGLDAGPAGDVLHLLVGFAGVGLAVACAWSARRHRRLSRTDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUS3</accession>
    <name>A0A7W7WUS3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="22638" checksum="7BCA0B768973651B" modified="2021-06-02" version="1">MSEPVAMHMSDGLLNAPTSLLFVAIAVVGVGVALVKARGDLDDRTAPLAGLVAAFVFATQMLNFPVLPGVSGHLLGGALAAILVGPWVGALCVTIVLVVQSLFFADGGVTALGANVTNMALVGTAVGFAVAVALRGLARRGKGGLAAVAFVSALVNTVLASFGFVVEYAIGGQGGVGFGTVAVAILGVHVLIGIGEGLITAATVTAVAAVRPDLVHLLRGVPQKLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH8</accession>
    <name>A0A7W7WVH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sterol 14-demethylase</fullName>
            <ecNumber evidence="1">1.14.14.154</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="436" mass="49135" checksum="FF2804057A46B073" modified="2021-06-02" version="1">MTAVPAMVSGAKPVFGHLAEFRRTPEELFHRGYREHGSVFSFSLAGRRAVVLLGSAHNRFFYAQTDGLLSIRAAYPFFSRMFAPEFYFFADPEEYQRQRSIVLPRFQGRQLEGYVTSMQRETAALIDELGDSGRFDMAALLGPLVLRIAARCFLGADIAVVLDRDFYTEFRRFAGGMGFFPPPWVPSPRNLRSRAARDRLRAAFRTLIERRRSHPIDPPDFLQTLAGAHYPDGTPVPDSVRVNLVLMLTWAGHETTTGHLAWALADLLDHPEDLRRVRAEIPPGPLDLAAVKHLEHLDNCLLETERLHPVAYVQARRATGDFDLDGHTVPAGTLVFTSPAVSHRLAEEHPRPDDYWPDRFAMGRDGRLARQALIGFGGGPHRCTGVHFAYQEMKVVLAMLLSRYEFTLVDGTPRPARGFVTKWPASPCRVDYRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ9</accession>
    <name>A0A7W7WVJ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024195">
        <property type="entry name" value="NUDIX_hydrolase_YfcD_pred"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017340">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017340-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="19037" checksum="BDBAA50CC9ADA39A" modified="2021-06-02" version="1">MGDTGEDVALFGPDGTPAGSASRARVRAEGLWHACAAIVVLSRDGRRIFVHRRTDTKDVYPGLYDPMCGGVVAAGETPDECARRELAEELGVREVPVPLFTNSFVDGTIRYFASVYVVRTDGPFTLQPEEVAWGGWLTVDEVRARVEDPDWPVVPDGRALIREWFRWVSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR0</accession>
    <name>A0A7W7WWR0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="41503" checksum="F7D409E49D01E402" modified="2021-06-02" version="1">MSPPPPVHPDETARVARIGIDLARRRWCAALDRAFRLPGLPVLDEHDGARRLAVIAHTLACAGRVSGARHYAALAHLALPDDDQVRRITAGVAALPRAGRDRAEPVEPVPRRAPCVHGIGPDTARAVGRAEQALAWLDHTATRSPHADAWARLMSWREARDSARLDGVHAALLEFLRHDLAPSGNHLVFADRVLAPYLTPTAAASTRSPPIDLVDIACRHVHRSPTTPHPHRTALAADLSRHLSGRWLPILGALADQDAAVPAGTASEAERFTRLIAEATAAACHTAVTVLHDLEHLHRRLATRLPTGRLSHLALRDLLTHGLITASGLARRHPMSAKSAHNILDRFLDLGLAVPYDHRRYARAVYNPDLIDLLTRTPEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT7</accession>
    <name>A0A7W7WWT7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15532" checksum="033F3B7F2D072705" modified="2021-06-02" version="1">MSERTIIQRTLRVPASTGAAGDGTTAARQLDAALPDVGFSASRDLLAHVGGPATGPALDLAATVVSAVRELVGDHVRHNAYFIDCPTTTRTCARSWRVVRSTRRGTRWRDRPTGLGQAPSRSRSGHGGTIGPRPWAAVVRRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX72</accession>
    <name>A0A7W7WX72_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma regulatory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4293" checksum="035CE5A4D03E6021" modified="2021-06-02" version="1">MLVLDLSGVDFFGLSRVNALIAVQAEADERSSGQLRLCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL5</accession>
    <name>A0A7W7WXL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protocatechuate 3,4-dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="6">
        <location>
            <begin position="257"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="31723" checksum="7805D09F4D0F24D0" modified="2021-06-02" version="1">MNAPLDGEHSSTEPAGNDAGLLSRKTVLRAALAAGVAVPVGLMAVPALARTIPESGGPLALTPACDDGDQPTIPQTEGPYFKPNSPQRTSLITGSTQGTRLTVSGYVFGRACQPIANALLDFWQADNAGNYDNVGFTFRGHQFTDANGKFTLTTIVPGLYPGRTRHIHVKVQAPGRSILTTQLYFPNEPRNNTDTIYDPRLLMTMGQDGNGKTGAYDFVLNVPQTTTTRPTTTTTKPTGPTGPTGPTGPTGPTGPGNTTWAVGTAYAAGAKVTFNGSTFTCLQGHTAQPGWEPPTTPALWRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN9</accession>
    <name>A0A7W7WXN9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19537" checksum="42F256392DA23D4B" modified="2021-06-02" version="1">MTGVVGEPELFRRAVATLRSVRTRPELELSVVRPPQRLAPWAYALTAEVTGPADELSTGRLVLLHDPDGVDSWSGIFRLVAYVRVELDPELASDPLLPEVGWSWLTESLEVSDAPFVALGGTVTQTSSARFGSIAGPARTDDLELRASWTATTPDLSPHGTAFYDLMATAVGLPPVGVTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ3</accession>
    <name>A0A7W7WXQ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell wall-associated NlpC family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030746706" evidence="2">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="197"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="33524" checksum="DCE2F10F89E5683C" modified="2021-06-02" version="1">MLAKIAIGAAAILLLIPVMIGQSVSAVVDALFGSSSNTTIDCTSPIADIPPEYCLLYVAAAPDCPGLDWTVLAAIGKVETDHGRLKAPGVTEGENFAGAGGPMQFLAPTFTGVIAKHQIPPGGASPPSRYNPHDAIHAAAFLLCDEGVRRGDLRAAIFAYNHANWYVDKVLEQAAKYAEAAATSVGNGDCNAIRAPNAITLAAINYACGQRGLPYVWGGNGPDGGHAGFDCSGLTKAAYAAAGVNLPRTAQTQYDAGPRVPAGQPLLPGDLVLYGTPGNIHHVGLYIGGGLMINAPTFGQPVQIDKYRYNGDDYAGATRPAASIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW8</accession>
    <name>A0A7W7WXW8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25556" checksum="875456F1E064B9DA" modified="2021-06-02" version="1">MTPPVFLVPALPAGSSMLLDGPEGRHAATVRRLRAGEELVLSDGTGAQARCVVAEALKDGLRLDVVERWVVPEPRVRVVVAQALVKGDRGELAVELATEAGVDGVVPWRASRCVTKWDEGPRGAKALERWRATVREAAKQARRARVPSVAEPVGTAELARLTSSSSVTLVLHETATGSIADVELPTDGDVLLVVGPEGGITDEELSALTTAGAHAVRLGHTVLRASTAAAVALGALGVLTDRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY67</accession>
    <name>A0A7W7WY67_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)/FAD-binding protein YdhS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="433" mass="46062" checksum="8E2C38B8B8701641" modified="2021-06-02" version="1">MDHTRSRVVIVGAGAAGVTVAARLAGLPADVSLVDPDPRPGRGVAYSTGHAGHLLNTPAGRMSAFPDEPDHFVRWASRLTGRAVGPGEFLARHHFGTYLGSVLAGCPVRHVRARAVGVRAGAVELADGRALPFDAAVLAVGAFPSSGSWAPPALVADSRFVPNPWSANAFVSVPDDLDVLLVGTGLTAVDVTMLLDRPGRVVHAVSRHGLLPRAHAPSRPVDVPRVEGCSDLDSVRALLVGRVRALGDWRTAVDGLRPVTAGLWQRLSEVDRARFLAEDVRLWDVRRHRMPPAAASWVGRTRAVGRLRVHRGSVVAADLFRRAVHVRLSTGSVLRVGAVVDCTGQHNDPALATDPLIRSLLRTGLIRRDPLGLGIRTAPDGRVLPLDAPLWTIGAPRRGDLWETTAYPEIRAQATTVAESVATHLSTTAYHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA9</accession>
    <name>A0A7W7WYA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FkbM family methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="873"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1215" mass="130496" checksum="D21ADF2609F4A04F" modified="2021-06-02" version="1">MTEVPAKAEARPALIACTVATAAQLPAVKALSGSFLANHPEGRFLALVVDALPENSGPGLVTPADLGVTPEELAELATGCTADQLCGLLRPKLLEQLLGQGVPVLYLDPWVHVLSPLTEVVLDAVRRGTLVLLPRSLRPLPDDDLRPTQSELLDTGVFDPGFLVVAPGAEVFLRTLSDQLRRTPDATKAVLDTAPAQVNVHVLRDATLGLSAWNAGQRALHRLDDGTITVLGEPLRTVHFAGFDPQRPWLLSAEFADRPRILLSEHPVLADLCTAYRAELVRGGHTPQRVRYGFGQLADGTRLPDRLRAGYREIARRDPRSAFAPEHAGEVPSDAPRTTPPAAFGPDQGLAFVAWACEPDDVHPRGTRWAAAVWHDDPALRAQFPDPFGADLTGFREWCATVGVAAARLPIPAVPGPVADAPALLDQLGVTIQGTGPVADVVRDVARASGLPTGDGYPVVVRLDDAPVPADRFVVDFRFDAAASTRADELWVPSETTKADVERTGGPAVRVLPLPAPEVDAPAPDGHEGLVFAAVADHAVDRAGNVLGAVSAFLAAFTDRADVALRIAVSGADDHPEAAERLRLATAADPRITLVEDVDPHADCLISVHRKGADDRIAFRLAGVAALGVPVLVARHGAVAELFDQSSAVFVPCRQGGEPDVQAAVKLLRVLADDLDTARRIGAEGRDRLRRTRTLAHSSDLMRDRVEHAYRAWRARRAAQKPTPATDPLRPLQSAKHALLRQPDVGKASRTPMAPQLRKVVLRLLDHYDNHMRDVLSSLVDGVERTVSEVVRRQDEVTTGIGIGELEVLRNEVEHHAEHAARLADQVLGLDDGVVRVRADMAGQGRRLRDAEDAVVAEAAKRAKQGDALAQRIDKLAVALERTLDRIDSLESKVVDVLRDRDSRMDVGIRAAGQAQLTADALRRVVVREHERHATSAPTVRSSLVLTDVGLLRLPADDAFMLPLLSSNGVWEPELSELIDSLVDPEGIFVDVGAYVGYQTVRMLDRLGPTGAVVAVEPCPSSCELLRHNVTVNLPERIAQRLVLVDAAAWESTGVLAASPSLTGGVSVAPLPSDAPEGADTVRSTRLDKELEAVPELAGRKLSVVRVDAPGRGHRALAGLVRLLRRDRPHVFLEFSATATESIGDDPVTVLKEFRVWGYDLVPVATREPAPAEQIVAAMEGLRSITLWLRPRPVAPKPPGPQVDVIARQPADQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ3</accession>
    <name>A0A7W7WYJ3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="6" type="ORF">F4559_005958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="18841" checksum="3233732D4886032E" modified="2021-06-02" version="1">MATTGSAAEHENPSAEIAEDGSRQAPASATGADEKIAEFEDRWRRTAADLDNVRKRHAAELRRATEAERARVAAAWLPVLDNLELALAHAEADPSGIVQGVHAIREQAVGLLAGLGYPRDDETGVRFDPNRHEVVAVVEDPATEPNTVTQVVRPGYGTDRHQLRPTAVAVSRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS6</accession>
    <name>A0A7W7WYS6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39657" checksum="7BE7ED6435DA14C4" modified="2021-06-02" version="1">MAEVSYDKASRIYSGNPPVRAVDALSLEVPDGEFLVLVGPSGSGKSTALRMLAGLEDVDEGAIRIGGRDVTHVPPKGRDIAMVFQSYALYPHMTVAENMGFALKLRGVNKAEIKEKVAEAARLLDLTKYLDRKPKALSGGQRQRVAMGRAIVREPSVFLMDEPLSNLDAKLRVETRANIAGLQQRLGTTMIYVTHDQIEAMTMGHRVAVLKDGVLQQCDTPRNLYDRPGNAFVAGFIGSPAMNLKTVPLSAEGALLDNLVVPIDRRVLDQAGREGLKEITFGVRPETLALVGGSQHGFDMTVELVEELGADALVHGAVRVGQGTERFVVRVDGRTPPALGQQVRVAVRDPRETHLFHPESGARLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ39</accession>
    <name>A0A7W7WZ39_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="18254" checksum="2F73D0141836C51C" modified="2021-06-02" version="1">MTTSAGDRHGEAERVGMALIRLNKMHACVVAQMTKAGMDKASFVLLATLRQLGPSRSSALAEAVFSDPSTVSRQVATLVKDGLVERRADPDDGRASVLAVTESGERLLDERRRQRNRAIGQMVADWPDEDLAEFIKYFERFVESYEKALPVFIAESGLGPRSEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA3</accession>
    <name>A0A7W7WZA3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="39" mass="4218" checksum="5693AF2344694048" modified="2021-06-02" version="1">MKKIIALVAVAGAVLFFVKRSRSAKADADLWREATAPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZG5</accession>
    <name>A0A7W7WZG5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavohemoprotein</fullName>
            <ecNumber evidence="6">1.14.12.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavohemoglobin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Hemoglobin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nitric oxide dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">F4559_006814</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the globin family. Two-domain flavohemoproteins subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLOBIN" evidence="15">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="159"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4969455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="43501" checksum="A8EEB10DF8358083" modified="2021-06-02" version="1">MTANAVLSPIPSPSHREPPPGVTAMMRLIRESWAVVEPRSEEVAKYFYGMLFSLAPATREMFPANMEVQRSRLLRALVHVVQMVDRPDDLLPFLRQLGRDHRKFGVVNSHYESVGMAMLAAIKKHAGPAWTPEVEMAWAEAYTIMARTMQEAAAADDGPAYWHATVLEHQRVGWDLAVVRLQPDHPIGYRAGQYVSVETPGRSRMWRYFSPANAPREDGIIEFHVRSVEGGWVSRSVVGHTAPGDVWRIGPPMGRLGVDRESGRDVLMIAGGTGVAPMHAIIDEMAQWGHNPRVHLFVGGRTREDLYDLDNLQRVAAHNPWLTVVPVLESDPGVRGVEQGTLADVVTRYGAWEERDVLVCGSPGMIRATVSRMLVAGTPLDHIKYDPFTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZT5</accession>
    <name>A0A7W7WZT5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="6616" checksum="ECC23677DBF5AAD0" modified="2021-06-02" version="1">MTFNPIRWLERYVEWWDERGRRNADGPSPMHIYWMWILWSVCAVMVVTTLAVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X011</accession>
    <name>A0A7W7X011_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate dehydrogenase E1 component alpha subunit</fullName>
            <ecNumber evidence="4">1.2.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="41"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="367" mass="41190" checksum="A9F6A262E9BEC3A4" modified="2021-06-02" version="1">MRATDEGGADLVQLLTPEGERVRHPDFDIDITPEELRGLYRDMVLVRRVDREANALQRKGQLGLWVPLLGQEAAQIGAGRALKPQDQVFPSYREHGVAWCRDIPPVDLLSIFRGTDNCAWDPIKHKFHPYTIVIGNQVLNATGYAMGQRFDGKVGDPDGEATICFFGDGATSQGDVHEGFVWAAVYDAPVVFYCQNNQWAISEPTERQSRLPLYHRARGYGFPGIRVDGNDVLACLAVSRWALEECRNGNGPVLIEAFTYRMDAHTTSDDPSRYRLSEELEVWKLKDPIERVKVHLVKQQWADQDFFDSVEAESEQVAIELRDKCVNLPDPSAESIFGNVYAEGNPVLEAQRDEFLAYHAGFAGGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X040</accession>
    <name>A0A7W7X040_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP transporter 4TM/12TM fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02123">
        <property type="entry name" value="TRAP_fused"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="2">
        <location>
            <begin position="116"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="639" mass="66659" checksum="856172214E9F63E6" modified="2021-06-02" version="1">MSEPILEQDEERPVRALSARWDRALAVAAFLVALLVLKQVFRPFAQGGQFYLVVFLAVTLPLVFLSYGRSADPGPLDWVLALLAFLAGAYPLAGFDAFLDRQGQLSTPDVIAGTVLLLLILEAARRTTGWVLPVVCVAFIAFAYYGGYLPPSWAISHAGVDFAQIVNGFFNDATGFYGTPLDVAATYIVLFTIYGAVLNASGAGTFFVDISFSLFRRSRTAPGRTAATAGFLLGTVSGSGTATTVSLGAVTWPMLRKAGYSKENAGGLLAASGIGAILSPPTMGAAAFIIAEYLRVSYLDVLVWAILPTLLYYLGIALAVEIDARRFGARPVDVEAPRAWTVLRRGGHHFLSLGVIVVFLVLDVPVYSAVVYATGVAALFALSSDLRGWSRLVATSLAVGVRGALPVIAVCAAAGVITSTVTKTGLGQALASALVDLASAVSSNPAVVLAVTAVLAAVAVSVLGLAVPVTASFVISWVVVGPALVELGVAPAEAAMFIFYYAVLSEVTPPTALAAVAAAAITGGDVVRTMWRTWRYTLPAFLVPLAFVLTDNGSNLLLHGTLLDALWVFAVSALGVAALAVATGGWLVRRAGVAERALCVPAALALLYPDPRSVAIGAAFLFAATVVHVLVNRKENRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SX88</accession>
    <name>A0A7W7SX88_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="86"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="32823" checksum="67E50D91278891A1" modified="2021-06-02" version="1">MTTTADLNRLATPPTFQSTSGARRFKNGFATALVYLAFAIAIVPLVWVLYTVVQRGFPVVLDGDWWQKSLSGLLARQSGGGVYHAIYGTLVQALVCGLLSVPIGLFIAVYLVEYGARSRLARITTFMVDILTGVPSIVAALFVYSLWITTFGLDRSGFAVSLSLVLLMVPVIVRTTEEMLKIVPDELREASYALGVPKWKTIVKIVIPTALSGILTGVMLALARVMGETAPVLVLAAYAPFINYNLFDGPMASLPLLMTVERNNPTDAGFDRIWGAAITLVLIITLFNLLATLLSRLLAPKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXC2</accession>
    <name>A0A7W7SXC2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multisubunit Na+/H+ antiporter MnhC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="726" mass="74949" checksum="821D53B8414CE0DA" modified="2021-06-02" version="1">MPTRWVDDLVLGVRLSVGGGRTSWARLALTAVAIGLGVAVLLLAASIGPAREAKSLRVRDATPETAISSDLLARQVTVTWRGRVITGTEFAGQGTPPPGVARLPGPGEVLVSPELLDLMGDDSLRARFPERVVGVIGDVGLPRPKSLLFYAGLPESLRADARPVGGFGGAGVPATLLPAYRVLTIAAIGALLVPLGIFTLVATRLGASGRGRRLAAIRLVGATRAQARWIAGGGTLAGSVLGLLVGVALFFAARPLTRFIEVEGVGFFPTDLVPDPLVATLIAVGVPVTAVAASLAASRRLEVGPLGLDPTAEVPARRPWWRFALLGVGAALLVTISWVGTYSEALADPVVATGLALGVALVLAGTGAVLPWLVGVVARRFDPDRIAVMLALRGLRSDVGTPRVLAGVAVVLAGSLALQVLLGVAARITETTVPRDAPDRWVLGMSDHTPVRSLEEAVSLVGGVRRVSEVRSARTGSGFEVVSSDCVEIAERLGVSDCVPGAAYRTGVGLPDAGTRTTLDGKPWTVPPYRDLGGRVRGWGALTVATGTDPLLASLPPVRLVVRGSPEPAFGDRLLAATGRVDRAVEPDVAVEAGQVELFTSLRGGVIGGSVLLTLLAMIGLVAAAVDQAWEQRRPVAVLAANGVPRRVLVGARWWQSTIPAAAALALAVPVGLVTAWLIVPADRFHVDWADLATTVGAAAAVVLTASLTTLPALRTVTHPTTLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE9</accession>
    <name>A0A7W7SXE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MocR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="472" mass="50267" checksum="8E7DE7082A27B36B" modified="2021-06-02" version="1">MAQLLGEWRRRGARQGSADLAAAIRMLVLDGRLPAGTRLPAERELAEALPVSRTMITAALDHLRSEGLVASRRGAGTWISLPSGGSLGGVPDTPLVGTSMVDLARAAPPALPGLLAAFDAVRVRLPEQLADHGYYEHGWPELRRQIALRYEARGVPTSPDQIVITSGAQHALAMTLRLFTGPGDRVLVEQPTYPNALDAIKAVSAIPVPVAMTAGGWDLTGLAAALRQAAPRMAYLVPDFQNPTAHRMSAEARARLADIARRARTPLVIDETSVELDLDGDPLDGPPPMAAFGDELVVTIGSASKSHWGGLRTGWIRASTEIVHRLVSSRTALDLGSALVDQMVLAEMIADPAHSLRSRRALLAVQRDALLDGIREHCPGWRFDVPSGGLSVWCELDAPVSTRIAVVAQNHGIRLAPGSRFGVHGGFERWLRLPFVLSPELLRDAARRLGLVAASVSGLAVPTDPPADVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXJ2</accession>
    <name>A0A7W7SXJ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,6-mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="194"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="39335" checksum="CAF32BED06464980" modified="2021-06-02" version="1">MRIVQLANFYGPRSGGLRTALHHLGAGYAAGGHEVTLVVPGPAHADERLGRVRRITLPAPRLPGTGGYRAVDPWRVRRLLDHLRPDRLEVSDRLTLRGMGHWAADNGVPSVVISHERLDRLLEQFLFPAALARRGADWANARMAASYDTVVCTTGFAKEEFDRIGARNVARVPLGVDLRTFTPTRHDRALKAELARGADALLVHCGRLSPEKHVERSVDTAAALHEAGHDVRLVIAGDGPRREALERRAAGLPVTFLGFVGERTAVATLLASADVSLAPGPHETFGLAALEALASGTPVVVSASSALKEIVRPGCGVAVPDHAPAFAGAVNALLDDPEPARRLAARTRAEEYPWQAAVDGMLAALRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXJ8</accession>
    <name>A0A7W7SXJ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="23990" checksum="4A60D1784B7C945C" modified="2021-06-02" version="1">MTYRSHGSGAPVTLIGHGLGATPGEARIPASGVRGTRVVVTLPGHGDEPDAPDDYWNYSRIAADLREVAREVGATRAIGVSLTAAALVALLAAEPDAFERVALLLPAVLDEPRPRLSRESMITSVDGPADYFEQRRWAFRRLDGALAALPGQVAVTDLSPLRRVVAPVLVVGAENDPLHPVTVAARTAAAFPNGRLEIVPSWPDARPSVRGWLADLVSDRPVPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXL9</accession>
    <name>A0A7W7SXL9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="45" mass="5253" checksum="4CA0CE376432FD27" modified="2021-06-02" version="1">MNDVDKRPQPRPEHDEAERPKTEAPKRLSGLEWLVKQAKKRTAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYE1</accession>
    <name>A0A7W7SYE1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="70"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="27757" checksum="338DBED8B3882A6F" modified="2021-06-02" version="1">MGGSSDVPALRRGLAVLRLLAGRPGPLSAAAVARELGLPRSTTYHLLAELTEAGFATHFPEERRYGLGVAAFELGSAYLRHDPLERLARPLLRRLVDTVDQPAHLGVLHGAEALYLLREQPQRPTTIVSDVGVRLPAHLTASGRAMLGRLPAAQVRALFPGTAAFVDRTGRGPHDLPSLRRLLTRERRQGWAVEDGYVTAGFASVAAPVFDHGERPIAAITVTFRHVCDDGCAATWPELAAPVRAAAEELTARIGGRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK1</accession>
    <name>A0A7W7SYK1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="11"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6665" checksum="E60163980A9F18F2" modified="2021-06-02" version="1">MVRDFSTAIFKTSTYTQDNGTCVEVGRVPGFVAVRDTKHRACGHISFPVDAFRAFLQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT0</accession>
    <name>A0A7W7SYT0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10144" checksum="66F0D918C53546A8" modified="2021-06-02" version="1">MDRSALDGLIARSGIADLPDSDEVPHRLRMGEFSPMECVRVLTRLHGMTLSEAKRKLFESAAWADRTDGWTKLQDGLEEVHGVPVIAVGRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ59</accession>
    <name>A0A7W7SZ59_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32793" checksum="11A6E66628BE2464" modified="2021-06-02" version="1">MTGVGEPAAVVSEVRKNYGALTAVDGVSFTVDQGEFFGILGPNGAGKTTTLEIVEGLRRPDSGTVTLLGENPWPRNPRLLPRIGVQLQASSFFEKLTAREQLHTFGSLYGVTARAVDEMLDLVGLTEKADVREDKLSGGQRQRLSIACALVHDPDVVFLDEPTAALDPQARRNLWDVLRAIQARGKTIVYTTHYLDEAEILCDRVAIMDAGRIIALDTPASLVRGLDAPTHVVVQKGALSVEDARGIAGVESVQEKDGALTISTRRPAPVLSALAERGTLDGLQVRTATLEDVFLRLTGREYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM5</accession>
    <name>A0A7W7SZM5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Acylphosphatase</fullName>
            <ecNumber evidence="3 4">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="8764" checksum="0F16A22B29444F11" modified="2021-06-02" version="1">MRGHVQGVGFRWWTRARALELGLVGSASNLADGRVEVNAQGSRTACDGLLTLLRSGATPGRVDAAVERWSTPRVGVTGFVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T001</accession>
    <name>A0A7W7T001_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="49068" checksum="3B75C5D639E221B6" modified="2021-06-02" version="1">MRIDPNTLSQLFPHGVAKTADLITLGLPSEKVLGRWPELLPGVVLLTRKPPNRPQRMQAALRYAGANAVVTGVDALHLHGIRSAPPTAGPVHVLTTRMPPPTRDLKVSTTRDVSPVLLQGFRTAPLHRAMADATHGIRTIQDLVTVLSEILRLHPNIGPRLRASFRGASPESRYVLAAMIFRHRNSFTRSQDGGRAKPDTALSPGGPDRPSDADLCAGPTHHGSTAPHSTEVTGATGRRSTDGTHRSVPESPSPDGQESGRDTPRRIRMVISRRAAPSGRRRFSSTAHRPAVMTFRHPDGKTVHRSADAPRQATLAKRTMTSVDTTTTEQLDAQTRRPGTARRRRRRSSTRRRDAAASRQPSSASTDQQTGHKATRKGLFRGGHQSTDASRRMATDSSYPMPPPSSPLARYWQGLYLFRAVTNAAERRTHRTRRRRASHPTTIPPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E8</accession>
    <name>A0A7W7T0E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28492" checksum="83CFE1E127F4A11A" modified="2021-06-02" version="1">MPITTLNGINLSYDVSGEGELVVLVMGTGGPGRVWQAHQAPALRAAGFRVATLDNRGIPPTDECAAGIRLADLVGDVAALIGHLGGGPASVVGTSMGAHVAQELVVTRPELVRKAVLLGTSARVDPVSQAMSRGERALFDDRVTLPASYHAAVNAVLNLSPATLRDPVAARDWLDVFEFSGQEITPGVRAQLELDDHEDRRPRLRGVTVPCLVVGFADDRVLPPYLAREVADAIPGARYAEVADAGHYGFLERPEEVNRLLVEFLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S4</accession>
    <name>A0A7W7T0S4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain containing-hemolysin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031288754" evidence="9">
        <location>
            <begin position="27"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="226"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="291"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="47968" checksum="B6087022D5E0F7B5" modified="2021-06-02" version="1">MTHILLAVLGLVAVVALTVGTFIAVAAEFSLTALERSTVESHLATVGDAKARTVDKAHRTLSFQLSGSQLAITFTTLITGYIAEPAIAELVSPALTGLGVPAGVARPISLVLALALATALSMVFGELVPKNLAIARPLETARAVAGTQAAFSNVFRWLITALNGAANWLVRRLGVEPAEELASARSPQELGALVRSSAAHGTIDEGTATLLDRSLRFGDRTADELMTPRMRVESLRADATVLDLLAKARETGFSRFPVHQGDLDEVRGLVHVKQAFSVPRDRRATTPVSALTRPVQTVPETLEGDALLDRLRASGLQTALVVDEYGGTAGMVTLEDLVEEIVGDVRDEHDRRETPPVRPLGRDSWLVSGLLRDDEVVEATGFSMPPGDYETLAGLVLSRLGRIPDVGDEIRVDGWRVTVMLMDRHRVAELRVARVGHPVEHVTEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S8</accession>
    <name>A0A7W7T0S8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="3">
        <location>
            <begin position="204"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="46134" checksum="775FFE15065E82AB" modified="2021-06-02" version="1">MINDHIGEHPKGMSVPVARAHEITPTASQRRRLTRPAWSRTAAHQQVIRARIVLDAALGHANAEISRRLRVTVDTVRTWRGRYADHGMAGLIDRPRSGRPSRVTPLQAAEIKALACRPPTQTGVPLSRWSCPDLAAEAVAQGITTAISASTVRRILASDAIKPWQYRSWIFIRDPDFRAKAARVLDLYARVWDGQPLGDNDFVISADEKTSIQARCRCHPTLPPGVSRTMRVNHEYDRGGALAYLAAYDVHHARVIGLCCDTTGIDPFMELAEEVMTQEPYASAKRVFWIVDNGSSHRGQAAIDRLTRRFPNAVMVHTPVHASWLNQIEVYFSIVQRKVVTPNDFTDLDQVQHRLTDFERRYNATAQPFRWKFTTTDLDDLLTRLDRHTPDQQEQPDFPQAAASSGGRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T101</accession>
    <name>A0A7W7T101_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system N-acetylglucosamine-specific IIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="15193" checksum="772A8BA441CFCFBB" modified="2021-06-02" version="1">MTLSVTSPVSGRVVPLADVPDPVFSQAMVGPGVAVEPDRAAADVVSPVDGTIVTLHPHAFVVATASGAAVLVHLGIDTVQRKGEGFTLHVAKGDAVTAGQKVVSWDPAEVEAAGFAPICPVIALDAAADALRDHTAGAVKAGDPLFSWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1C0</accession>
    <name>A0A7W7T1C0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031026484" evidence="1">
        <location>
            <begin position="32"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="17915" checksum="B8D1E06EEB615503" modified="2021-06-02" version="1">MALRKRLAAAVAGVIATPLVLVALPTSPASAHGYVSSPASRQAQCARNVVACGSIKYEPQSVEGPKGLRSCNGGDARWADLNNDSKGWQAASVGRTATFSWTFTARHATASYEYYVNGTRVASFAGNGKQPGASISHQVTLPGSGRQKVLAIWNISDTPNAFYACIDVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1I1</accession>
    <name>A0A7W7T1I1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21596" checksum="E8DB6D1CA53B1DD8" modified="2021-06-02" version="1">MTPDYPVRTARLVLRPFTAADEAALHSWESRPDVVRYLYGEARTPDESKVNLARKMSVPWPEKEGQDLCLVIERDGVAVGEAVLKYLSEEHRQGEIGYIVHPDHHGHGYATEAAAAMLELGFGLLKLHRIVASCDARNDASWGVMERLGMRREAHFKHSELFKGEWGEEFVYAILEDEWRTSPLAANGIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P5</accession>
    <name>A0A7W7T1P5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ORF">F4559_001811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="13903" checksum="C6A2DB468C84098E" modified="2021-06-02" version="1">MIPEELKYTEEHEWVLRTGEDTVRIGITDYAQTQLGEVVFVQLPELGEQPAAGQTLGEVESTKSVSEIFAPLAGEVVARNDSLDQEPDLINSDPYGEGWIVELRLTDPAAVDDLLDAAAYQELVTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2B4</accession>
    <name>A0A7W7T2B4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding LacI/PurR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002081</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="32150" checksum="73001F1845BA7C8B" modified="2021-06-02" version="1">MELASMSDVARAAGVSAATVSRALRGEPGVSDATRRYVTEVAERMRYAIARDASSLAGGRRYAVGVLTAEGGRGDLLAGAEAALRDAGYDVLLYVLRDRAAFFERLPPARRVDGLVALGVTLSADETGALAGLDVPLVEAGQDDPHDALRVAADHLVSLGHRDVALVLTEDADESYDDVLVAAGLATRPEWTLWSSPTVAGGEQAVEVLFDGGGRPPTAIVTAHAAVAIGVLLRLRRDGRDVPRDVSIVSLDDCELVRTVGVTAVEGAWRDRGARAATSLLTTLGVRAPDTAATVRSLVGGSVAVPGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F9</accession>
    <name>A0A7W7T2F9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="818" mass="85485" checksum="83303A466FC9D8DC" modified="2021-06-02" version="1">MSTGVSEVDGRLIGGRYRLTRRTGQGANGVMWHAVDEVIGREVAVKEMRPPGGLTAHERGLFVARALGEARTAGRIDHPGVVAVHDVLPTDDAVHLVLELVRAPSLAEVLDREGPLPAERVAVLGGHILDALRAAHAAGVVHRDVKPANVMVLPDDRVKLVDFGIAPTVGDERSTREGVPGSTGYMAPELFDGAEPSAASDLWALGVTLCQALTGVGPFERDTAASTVHAILFADPPPLSGPPAEVVTGLLTRPVERRLDAAGADRLLRAPATGGAPTAEQSTGDSRVTALSSRRPDVPYRTRLRLVRPPRSGTVVRAGFFVVAVLFVVLAATLPLPVGVWAVLGPLSLMSAITFHLRFPHRWWDAVEFRERGVVLLRTHRRGGGTVVHDLALPWSDITGVAGAAVGARTRLSLHMAPRPKAERKSEPFRGFVGRVAPDRSFTWVVGDLEAPPDEVVRRVGDVAPPTMRVLGPAEAVGPVYLRRDSYVVSAVIGALVLVATVVVALPNVRHDYAEQVAADSRFTVLAASLRGNAVAAGAADGTVSLFRTGATAAHAVVRGTAPVKLLVLTSDGTTGASADADAVRVWSADTGEVVGTPLPLPARALALGESGDVLAVAGEDAVRVYTKRDNGFAPAAVIDVARDLGLIAVRAERTRAEVVGLDAHGTGHRRVFGYDRLSGVLDPVPSPPGEVVPPGTPSGVVLTADGMSWSLPTSTADVEVRRESGQSYAVPTGHTGAARVVAFPDDDALVTAGPDGIKVSDVVAGTVEASFDPDGEIAVATAAIGDDLRVLVFLRPDEPGLWMWKTGMRGGCDGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2G0</accession>
    <name>A0A7W7T2G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheY-like chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16435" checksum="CAB8E536CEB18206" modified="2021-06-02" version="1">MSDPLSVIDVLLVEDDPGDALMTQEAFEHHKIRNLLHVVRDGVEALEFLRREGRYADAPRPGLILLDLNLPKMDGREVLAEVKADASLRSIPVVVLTTSEAEEDILRSYNLHANAYVTKPVDFDRFIEVVRQIDDFFVTVVKLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2S1</accession>
    <name>A0A7W7T2S1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stearoyl-CoA desaturase (Delta-9 desaturase)</fullName>
            <ecNumber evidence="9">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="35253" checksum="33C527AAFB1F00E9" modified="2021-06-02" version="1">MRTEVPPTVRADTAPQPLLAGEKSATEMFLVKLFAVIPALALAAAVPLAWGWGLGWVDIGLAVFFYTLTCLGVTVGFHRHFTHGAFKATRALRIALAVTGSMAMQGPVIGWVADHRRHHAYADREGDPHSPWLFGTSARSLAKGFWHAHMGWMFQRDMTNPARFAPDLVADTDIRRVDRWFPALTAVTLLAPALAGGLLTWSWWGALTGFFWAGLVRVAVLHHVTWSVNSICHMIGDRPFTARDRSANFWPLAILSMGESWHNSHHADPTCARHGVRRGQIDVSARLIWLFGKLGWATGIHWPQPERLARRLKATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W6</accession>
    <name>A0A7W7T2W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="11580" checksum="EB981FBDB961240F" modified="2021-06-02" version="1">MYRLGISADGRRLATPGKDGTVRVWDVGDPAAPVAVATLTNHGDSVKSASFSPDGTVLATGSADATVRLWHLDAGEATTRVRARVRTPIDPAEWQRRFPGLPHDPPCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T368</accession>
    <name>A0A7W7T368_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="38697" checksum="BEADBB9D4B81670C" modified="2021-06-02" version="1">MVTTTTTADPAVKRARFAITAVFVVHGVVLGSFATRLPWIQQHAGVGPGQLGLALACPAIGAALAMPLASRITHVLGTRNALRVLLSLWTLALILPSLAPNLVTLCLALLTFGAAAGSSDVVMNAVGVEVERLLGRSIMSGLHGMWSAGTLVGSAVGTLAAHLEIPAPVHHLGAAAVLTLAGVVVTRGALDMRPEPDAEAPPRFSLPTRGALLIGAVAFCAVFAEGASLDWSAMYLKDVLGTSAGLAAASTTGFTLTMVVARVLGDRVVDRFGAVTTVRTGAVIAVAGGLLVVLSGSPVAAIAGFGLIGLGVAVVVPLAFAAAGHRGPDTNRAIAGVATLMYTSGLIAPSLVGGIAEATSLTVSFLVVTALAAGLVLFAPVLRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I6</accession>
    <name>A0A7W7T3I6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13959" checksum="C5D1A7992A8C15BB" modified="2021-06-02" version="1">MDVAEARFDAFNALCPSRRLLDTIGDKWASLVIVALGLEGPLRYSRLATRIDGVSQKMLTQTLRGLERDGLVTRTVTPSVPVRVDYALTPLGLSLLGTLRHLKDWAEEHMPQVDAARAAYDRGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q1</accession>
    <name>A0A7W7T3Q1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">F4559_003323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4965964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="29514" checksum="50C177E0972BCF91" modified="2021-06-02" version="1">MSWLQALVLGLVQGLTEFLPISSSAHLRIVSTLFFGNDAGASFTAVTQLGTEVAVLIYFAKDIGNFVSAWFKGLFSKAARKTDDYRMAWYVIIGSAPIAILGYVFKDQIRSELRNLWITATVLVVFGIVLGVADHFGKQARDKLFLKDAVGMGLAQAMALIPGVSRSGGTLTAGLFLGLDRAAAARYSFLLALPSVFGAGLFSIPDVLDRSEPNAASVPQMIVATAVAFVVGYATIAWLLRYVSKHSYSAFVWYRISVGIVLMGLLSMDLVKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W0</accession>
    <name>A0A7W7T3W0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="134"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26473" checksum="E62ED204CFE6844B" modified="2021-06-02" version="1">MLTTDYLTGVPNWLDLGSTDVERSAAYYTALLDWTHEPLGPEAGGYGFFRHDGRIVAAIGPSTEPGAWTVHLNTPDADATAGAVRAAGGEVRVEPDDVFTAGRLAAFTDPTGAEFAVWQPGDRVGLDAVTVPGSLAWIELHTTDVAAAVAFYTGVFDAEASKVPFSGGEYTVLTPRGAGDERSFAGVVPVGDGRSRWVAYIEVTDVEATFARNTELGGGVLMPVEHVPGVGRMAWLTDPLGTVFAVIQSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T418</accession>
    <name>A0A7W7T418_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15485" checksum="5C53523F7E54E594" modified="2021-06-02" version="1">MVPTEPGVTDTPLGKAGCSLPGRLLNPFVDAEALASITPADIASHSGTMTALVYLVSDGYIAYPHGGTATELPCLVFRKEPAAGIVEAVRVQEIEWCEAHRLVDSKPTAEAYGSVIDVVHTIATRWLRITGAIGASVPVPSPRPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T431</accession>
    <name>A0A7W7T431_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21353" checksum="D76525CEEA0763E8" modified="2021-06-02" version="1">MANDKRPLFDHRLRERFLGQRVLVLDGPLDDDNGTALATQMLSLAAESPGKDIALWINSPGGSVPAMLAIRDVMRLVPCDVATLALGLACSAGQFLLSAGTKGKRYALPHARILMHQGSAGIGGSAVEVEVQADDLRHTRDTVLALISEDTGRPVDQIFTDSLHDRWFTTAQALEYGFIDHVVGSLDQVVPVRATNWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T432</accession>
    <name>A0A7W7T432_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="30321" checksum="74C16C38B4F45C43" modified="2021-06-02" version="1">METFHNGLANARRAVRTGDVDQAVLVAHRLWTGYGPYSVHMVNGLRELHKEITATSPSGEAASTLFEDAATALAGFGLLRQAEEEWKRCVEVWGRREAADPTDHNRFGYVAAIENLAGAFWARERQDRVVDCLDRSIACYDRWGWKGHRATAFRELGAVLLCAGRFEAAEQYAIIAEKQHDEVSAETGRTCLDEVKAHVLHARIAHARGRKFGARQSLNSARALAARLTPDRSAEIDFLIRSTRDGRKMPSVTTTFPIVEYGIVAEDLDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T442</accession>
    <name>A0A7W7T442_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetylhomoserine (Thiol)-lyase</fullName>
            <ecNumber evidence="5">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="44786" checksum="B9BC37C97A1C5D29" modified="2021-06-02" version="1">MVGRRDVTRRWSFETRQVHAPAVPLYQSTSFVLGSAEHAADVFALRDLESHAYTRLSNPTTQVVEELVADLEGGGAAVAVASGQAATALAVLNLARSGDHVVASASLYGGTYTLLAHTLADFGVTVDFVRDPDDPDAWRAAVSPSTRAFYAETVGNPRGDVLDVAAVAGVAHEAGVPLIVDNTVPTPYLERPLEHGADIVVHSTTKFLSGHGTGIGGMVVDGGRFDYGADAERWPGLTRPDPTYDGLVFTEAFGDLAYALRLRARLVRDLGPAVSPFTSFLLRQGIETLSLRMERHTSNARTVAEWLLAHPRVTAVHYAGLPSSPWHDRAARYLPRGVGAIVAFELSGDARDFVDRLELFSHLANIGDVRSLVIHPASTTHAQLSPDRQRAAGVTPGLVRLSVGLENVADLIGDLDGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A5</accession>
    <name>A0A7W7T4A5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031389032" evidence="1">
        <location>
            <begin position="39"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23689" checksum="59879A38494A4EAB" modified="2021-06-02" version="1">MRLTSPHSDTPVTFGKLFTAFALGLALVLLGSGTIARAAAHDARRNCECSTPSIDRYQQWLASGEGTTVPATGSLLVREGRGYAAKVQFLKDEWHVVVVWLGNKFESQADLSKSSGFWLTYSATDDLYLQLRPASHWSGGDKWLVKIPATGGKRVQKFVAFTADQWTWLPELGKPAYSFESALTDARGFVFVGKTPNRIDFRGLRIDRYQPPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4H4</accession>
    <name>A0A7W7T4H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="25501" checksum="1E53EEBD6EB94879" modified="2021-06-02" version="1">MHTNDVALVTGANKGIGREIVRRLAERGLTVYLGARDPQRGRVAAEGLEDVRSVRLDVTDPASVAAAVTRIEAETGRLDVLVNNAGVVVEWGVGIADLTAAHLREAYEVNVFGVVTVTAACVPLLRRSPNPRIVNMSSGLASLGLLGDLDSPFPTRDLPAYSSSKAALNALTLIYAHALRADGIKVNATSPGLVPTDGNAAASFPRGDRTPADGATVPVLLATIPADGPTGTFRGPDSLDQVIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S5</accession>
    <name>A0A7W7T4S5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methanogenic corrinoid protein MtbC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="91"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="35308" checksum="DC62328C20AB337D" modified="2021-06-02" version="1">MTTAHDIEEQLWGAVAAGDETAATDIVLTGLGGGLGAETLLLDVIGAVQFRVGAEWAANRLTVAQEHAATAINDRAVAALVGAVGRPAPHRRHVTVACLPGEWHALPARLLAEVLRLRGFRVDYLGAQVPTPHLVAHLHHTAPDVVALSGALATRLPTGHATIRACRSAGVPVVAGGSAFGVDGRHARVLGADLWALDARAAAQALEAPLPRPSPDEPDSLPHLADQEYTMVARTAGQLVKTTYTGLEQRIPGLRTADDAEREQVAEDIAHIVDFLATALYLDDTSLFADFLTWTAQVLAARGVDPAVLAPTVDILAAQLRDFPRASTLLEPGPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V1</accession>
    <name>A0A7W7T4V1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase complex protein LldF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024569">
        <property type="entry name" value="4Fe-4S-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11870">
        <property type="entry name" value="DUF3390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="468" mass="50165" checksum="4AB1194252FF6750" modified="2021-06-02" version="1">MTFLGMPTLSGEPFPTAARAALGDAQLRRNLAKATGTIRAKRARVVEELPDWAGLRAAGAAIKDATLADLDTHLLAFEADLVARGTTVHWARDGAEAARIVTDLVAATGTREVIKVKSMAGAEIGLNDAFDAAGIAPIETDLAELIVQLGHDRPSHILVPAIHRSRAEIRDLFRREMPGVAPDLTDEPAALAEAARRFLRHKFTTVDVAISGANFAVADTGSLVVVESEGNGRMCLTLPRTLISVVGIEKLVPTWSDLEVFLQLLPRSSTGERMNPYTSVWTGPTEGQTAHVVLVDNGRTATLADTVGRAALRCIRCSACLNSCPVYARTGGHAYGSVYPGPIGAVLSPQLTGVAHNRTLPYASSLCGVCQDVCPVAIDIPSILVHLRGKVVEDHAPVAEAAAMRALAWAMADAGRWRRLLRAGRLGRALGRRRDRIGSLPPPLSAWTGTRDAPRPPRQTFRDWWESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X4</accession>
    <name>A0A7W7T4X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR02246 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14354" checksum="0E4735F8F3BDA1DF" modified="2021-06-02" version="1">MTDGIAEWGRELARAWERGDATAYADAFTEDAEYVVFDGRRLSGRREIEDAHRWLFSGPLKGSRLVGTTEVDVPPRFLRPDVAVLVSGGAVAGPDGGVPAGAASVQTSVLVREDGRWRCASFQNTRVTFREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X7</accession>
    <name>A0A7W7T4X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.17" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000908">
        <property type="term" value="F:taurine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="3">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="34150" checksum="D7235CFD817788A0" modified="2021-06-02" version="1">MSLSLESSESDISGVSVARLGSGIGARVDGVRLGGDLDADTVAKVRATLLAHKVIFFRGQQHLDDAGQLAFGSLLGEPTLAHPTVRGRQNLNVLPIDSDYGKANSWHTDVTFVDRVPAISILRAITLPTYGGTTVWANTVTAYETLPPSLKALVDQLWAVHTNAYDYAANIDELRIGGVDVKTEEYRKEFVSDLYETEHPVVRVHPETGERALLLGHFVKRLIGLSSTESQAVFNLLQARVTRLENTVRWDWQDGDVAIWDNRATQHYAVADYDDQPRRLHRITLAGDVPVSVDGTPSVIRQGDASHYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T548</accession>
    <name>A0A7W7T548_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="623" mass="67448" checksum="ACE07405D4D8064E" modified="2021-06-02" version="1">MRFRLLGALDVRDATGAVVFVGPRQRAILAALLLRANEVASVGYLADAAWEVLPAKPHSNVRTYISGLRRRLGDGPGSGERLLTRPGGYVLRVAPAELDLTVFEELAGQGERAMLSGDLHRAVQRFEESLGQWRGKPLEGLSVGTPLRAELSRLEERRLTVVERHGEAAIGLGRHEGLIANLRLLVEDYPFRERLWAQLMLALNLAGRQAEALRAFHDARRMLDEELGVDPGPELGELHQRILRGEIEPAPPVSARILVGAAPDDGRTAVTGGGRRGVPSATASDPAPSQLPPDIGDFVGREPELRQVIDRLTHEDDTMVLPVAVLSGQRGIGKTTLAVHVAHRLRCHYPDGQLYLDLGGSGSVPRDARSLLTQLLRSLGIVVSDPAVDLADLSGLFRAGLAGRRVLIVLDDAVRAEQVRPLLPGDARCGVIITSQSRLTDLPATVRVRLPPLTETDAVELLGEVAGAHRLRSGYDDAVELVRLCDALPLAVRAAGARLAAKPHWPIGQLVFRLSDEHHRLDRLDIGDLTVRARLAASYGSLDATTQRAFCLVSLMESDEFRACAAAPLLEVPVGKATDLLEALVDAQLIEATPARDGIRYRMPVLVRLYAREKAVTMCDATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T563</accession>
    <name>A0A7W7T563_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase PknK</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18675" checksum="A53388A4F296799A" modified="2021-06-02" version="1">MPPGLTDDGARAARHIRRRHPRRRHPRLGIVLLSPHTETRHSVELVTSGRFGYLLEDRAFDVEDFLDASHRVAAGGSALDPEILSRPLTKRPRDDPLSRLTTREREVLALMAEGRTKVGTSRRLRLTDRTVETRIGSILAKLGLADSDEDHRRVLAVLLYLDHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N5</accession>
    <name>A0A7W7T5N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3D (Asp-Asp-Asp) domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007132">
        <property type="entry name" value="DUF346"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03984">
        <property type="entry name" value="DUF346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031422880" evidence="1">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="32341" checksum="531905D32F842B65" modified="2021-06-02" version="1">MKSLVAVAAGLVLFGSSTVAASPSRAAGWSGWEDLGGTLTAGTTVSSWSSNRLDVFVRGADSAVWHKWWNGSSWQGWESLGGVIIDNPAAVSWGPNRIDLFGRGTDNHLWHRWWNGSSWSGWEDLGGIITAGPAVSSWSADRLDVFARGTDGAVWHKWWNGSSWQGWESLGGIIIDNPAAVSWGPNRIDIFGAGTDNHLWHRWWNGSWSGWEDLGGVITAGPTVSSWSANRLDVFAKGTDNALWHRWWDGVAWRGWESLGGQFLHNPGAVSWGPNRIDVFVAGLDNHLWHKWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5X3</accession>
    <name>A0A7W7T5X3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11864" checksum="77C0D4E55B3542D9" modified="2021-06-02" version="1">MRVPLGTIMGARSGDKGGDVNIGVWVRTDARYRWLSRELTTARIKELLPESGVVTRYELPNLRALNFVLHGLLDAGSMASTRHDPQGKALGEWLRSRHMEIPDVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T625</accession>
    <name>A0A7W7T625_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="27016" checksum="2A9561F9D365C94B" modified="2021-06-02" version="1">MSVYTTGLLWVGGAAVFASLLAYVIRKYGPDEGRSENNEAAGQVFTIVGGLQAVLVAFVLIALFDGVAAAGNASYEEADSLVAATWAGDALGERTGDEVRRLSREYLETVVDEEWPRMRSGDESDDAGWSTLDRLRRVIAEAPATDAWLVDRKTEAADKLWQVYQARQTRLDSATEGVDAVVWFVLVMGGILTIGLPLLFGGPLMRTHVIIVATLAATITLLLYATYQLQNPFGGGAELQPDAFSAALSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A3</accession>
    <name>A0A7W7T6A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase-3</fullName>
            <ecNumber evidence="5">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="4">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="3">
        <location>
            <begin position="246"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="36512" checksum="5F3A31378527885B" modified="2021-06-02" version="1">MRADDVYLAGVGVHLPPAVPTAHAVARGDYPEADRNAAGYRSVLVAGDLPAPDMAVDAARAALRHAGLPADAFGALIHSTTYHQGPDGWSAPHYVLRETLDRPISAVELRQGCVGMISALELAVHRLTADREHDAVLLTTADNFSVPIVDRWRAAKLFVLGDGGAAAVVSRRGGFARVLSVAAYSNPGMEALHRGGERLFPPGITRGISLNFEERSDYWRAQWAKGVTPPMGHLGECVAGAADRALADAGIDLAKIARVCHVGFARGPLHAIYLDALGIEPERGTWEVTSRTGHVGAADPFIGLEHLWRTGEVGPGDHVLLIANAPGMEAGCAVLEIVEPPETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6E5</accession>
    <name>A0A7W7T6E5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20183" checksum="60012038E849EDE3" modified="2021-06-02" version="1">MTSVATLYALRCMGSCGTARIAVALGTEESTVDSDLIDLAVAGMVARAQGAWCLTDKGRAADAWYRAEEVKAVHDAVMAAYKDFMVLNPELLDLCTAWQLRRADTDRVLELFADFDHRADAVLEALATALPRFARYRERLSAALARARSGESAYLADHLESYHTVWFQLHEDLLATLGMPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T746</accession>
    <name>A0A7W7T746_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="34610" checksum="F7FEB8536B526B51" modified="2021-06-02" version="1">MRHETPVLAGDLAQALRYGPFDRALAAAIRRRGLSLGRLRAHLRAHGVTIAQSTLSYWQRGLRHPAVPRALDAVRALERVLGLPEDSLVVLVGPHQRVVLPEQRVPSIPELSRSWTRTGELLAEFDGVSGSPCNADLDVVTVFDDVRLTAAGETAEITSVMAVRARRSGPDGFVVTHQSEPGADIDSARLRAGDGCRLGRVRRRRSSAGMVFELLFDRKLAEGDVHVFAFTLVCTTPVRAPTYYRVVRGRMQAYLIRLHFDPDRLPVRCTRVQRAREGVEPTVSEPLLCGPSGFACAYFESLAPSLVGVDFLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A5</accession>
    <name>A0A7W7T7A5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Assimilatory sulfite reductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.8.7.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3 H2O + hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] = 7 H(+) + 6 reduced [2Fe-2S]-[ferredoxin] + sulfite</text>
            <dbReference type="Rhea" id="RHEA:23132"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.8.7.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0883">Thioether bond</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="96"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="167"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="9">
        <location>
            <begin position="340"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="8">
        <location>
            <begin position="417"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="560" mass="61888" checksum="1184FDF3D79486CD" modified="2021-06-02" version="1">MVPPTTTPGRAKQRRGEGQWALGYREPLNPNERSKKDDNPLNVRARIENIYARGGFASIDPGDLRGRFRWYGLYTQRKPGIDGGRTGALEPEELDDEYFMLRVRIDGGRLTTQQLALIGELSQTYARDTADITDRQNVQYHWIRIEDVPALWQRLEDAGLTTMEACGDSPRVVLGSPVAGISADEIIDGSPAIDEILERYIGDPRFANLPRKFKTSISGRQDTAHEIHDIAFVGVEHPEHGPGFDLWVGGGLSTNPMLAKRLGVWVPRDEVPAVWEGVISVFRDYGYRRLRHRARIKFLVADWGPEKFRQVLEDEFLGRKLIDGPAPETPARPIDHIGVHRQKDGLFYVGAAPVAGRVSGSILVEVAKAVERAGSNRVRLTPQQKLVVLDVAEAEVKGLQAALAELGLQTEPSPWRRGIMACTGIEFCKLAIVETKARAATLVDELESRLADITDGTTAPLAVHINGCPNSCARIQTADIGLKGQIVTDEAGNQVEGFQVHLGGGLGLDSGFGRKLRGHKVTATDLPDYVERVVRNFVAQKEEDERFAQWVARADEADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V4</accession>
    <name>A0A7W7T7V4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_005484</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="12">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="136"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4968125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="45433" checksum="027415A2E007A86E" modified="2021-06-02" version="1">MSTSTALLTDHYELTMLAAALRDGTADRPCVFEVFARRLPEGRRYGVVAGTGRVLDAIESFRFGEAELELLRRTAVVDDATLEWLAAYEFTGDVDGYPEGELYFPGSPILSVRAPFGVGVVLETLVLSILNHDSAIASAAARMVGAANGRRMIEMGSRRTHEEAATASARAAYLAGFTATSNLEAARRFGIPTTGTCAHAFTLLHDDEESAFRGQVEALGVGTTLLVDTYDITKGIDTAIAVAGPGLGGVRIDSGDLGVLARQARDQLDSLGAKDTRIVVSGDLDEYSIAALRAEPVDAYGVGTSLVTGSGAPTAGMVYKLVDVDGRPVAKRSSHKESRGGRKSALRRHKDTGTALEEIVFPVDDRPEAAEHDRELPVPLVRGGRRVEGLDTLAQSRERLRAALVSVPWEGLKLSRGEPAIPTTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X9</accession>
    <name>A0A7W7T7X9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="38443" checksum="D45EB9DB4D694707" modified="2021-06-02" version="1">MDASLLVIVVVVTALAFDFTNGFHDTANSMATSIATGALRPRTAVAFSAVLNLVGALLSVEVAKTISGGIVDDARITPAIVFGGLVGAILWNLVTWYVGLPSSSSHALFGGLIGATWIASGADAVHFAKVVDKVVVPSVAAPLVAGIVALLATVLTYRLSRRTDEKVRDRGFKTGQIASAALMSLAHGTNDAQKTMGIITLTLITAGTLAPGSEPPLWVILSAAVAIALGTYLGGWRITHTLGKGLTTIEAPQGFAAQTSAATVIMASSHLGFALSTTHVASGGIMGSGLGRRLDGVRWGVAGRMALAWLFTLPAAGLVGALAGKVASLGTAGVVAVAAVGIAVSLVIWLMSRREPVRPEHVVDELAAQAEPHKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T856</accession>
    <name>A0A7W7T856_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="216"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="31714" checksum="C90018EA49FEA91A" modified="2021-06-02" version="1">MRDPMGIGISRTTELSSSQRTLSALRANQNRGEELRQQVTTGRKINTPSDSPTGAVAAMRLRTDLAAGERYTRSAADGTARLGTAENALLGVSNYLNQARDLVVQGLNATASDPTARVALAGQIESLRDAALSAANTSYLGRPVFGGTTANSRAFDDSGAYLGDDGEVLRRVDARTQVRVDVPSTVFGTGTDSVFSVLSTVASKLRSGDPTLNTELDRVDSRLSSVNTELAAVGSRYSRLTTAVDVAKDRAVTLTGQLSDIEEVDLTEAVVSLQTQSTAYQAALAATARIQQPSLLDFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T904</accession>
    <name>A0A7W7T904_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">F4559_005920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="35467" checksum="A8E6CD6E594E1E98" modified="2021-06-02" version="1">MTGTPKKNLMLFGGRAYPELAEQVAQHLNVSVTPQSAYDFANGEIFVRFEESVRGCDAFVIQSHCAPINQWLMEQLIMVDALKRASAKRITVIMPFYPYARQDKKHRGREPISARLIADLFKTAGANRLVAVDLHTAQIQGFFDGPVDHLWAMPLLAEHIRDKYAGRDWTVVSPDAGRTKLAEKWADTLGGAPIAFIHKTRDPLRPNEVVANRVVGQVKDRLCVVIDDMIDTGGTIAKAVDQLLAEGASDVVIAATHPVLSGPAVDRLKNCGAREVVFTDTLPIPPEKRFDSMTVLSIAPLLARVIQEVFEDGSVTSLFDGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T920</accession>
    <name>A0A7W7T920_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GntR family transcriptional repressor for pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="224" mass="24399" checksum="28AB699D730A8DDF" modified="2021-06-02" version="1">MAVTDDAILRVREMIVTGELKPGDRLPREADLAERLGLSRNSLREAVKALSLVRVLDVRQGDGTYVSSLRADDLLGALSFVLELHRGQESTLEVLQVRRILEPAATAMAAQRVGPEEVASLRALCDTAESAHSLEELVAHDLEFHQAIARCSGNAYLAQLLETMAGPQARTRIWHGIAEGGAVERTVSEHRAIVDALANRQTELARSWSTVHVAGVEQWLVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T921</accession>
    <name>A0A7W7T921_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="41" mass="4548" checksum="891CB8FC737D9360" modified="2021-06-02" version="1">MALAMDPAWRRAARVFRMRAAAVSWVLPGQIARHSRDVAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T937</accession>
    <name>A0A7W7T937_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07474">
        <property type="entry name" value="Peptidases_S8_subtilisin_Vpr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034213">
        <property type="entry name" value="S8_Vpr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030630919" evidence="6">
        <location>
            <begin position="21"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="151"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1046" mass="108424" checksum="5C8184F6C6140B82" modified="2021-06-02" version="1">MRLVAVLTAALLSATGLAGAQPAGAELTGSGRTATVFVELATSSAVDAFEREDDRGRAIGAARESRRLIGEITDKVLKALRDKDSRARQVARTANAVPGFVVTGDAARLRELSALSEVRSVRAIVPKTASNSGAAQLTRAVKVWQDNGKLGEGLRIGVIDTGVDYTHADFGGEGTVEAYRAVDRTAPWTPNAKVVGGHDFVGDDYDADDPDHATPVPDPNPMDCFGHGTHVAGTAAGYGVETDGSTFRGDHRMLTPEHLDRMRVGPGTAPAAEIYALKVFGCTGSTNLTAEAMDWSLDPNGDGDFSDHLDVVNLSLGTDFGGQDDPDSLFVRKLVRNGVLVVAAAGNGGDFYDAGGAPGNTPEALTVANTRDAHVLLDGLGVTDLGDQPGQYSQDYRDFPALDLTRPVVRIQEESNVDGCGPVSQDLTGKVVWLEWDEDDATRECGSKARTDNAEKAGADGVLLTSTRAIFAAAIAGNATTPVFQFTGPATQRVRPLLDAGTLEVRFQGTGRRALPTLAPSIADTITPTSARGARGPVGAKPDVAAPGDTIVSAAVGTGADGVSKGGTSMSTPHVAGIAALVRETHPDWTVEEVKAAVVNTADATVVSGDDRATGVPEAPMRVGAGRVDARQAVDTDLLAMVADDPGSVGVTFGTVPVNRSALLMKTVRVVNKSTTRRTASVAYRPSTEVPGARIEVRPSEVSVPPGGEARVRVTLRVTASELRKVADPTLRTTEDGRARQFLSEASGLVVVSSGEAAARVPVYAAPKPVSALTAAMADGTVRVNGRGFDRGGYASMVSAFELQGRSPELPPCDDEPQVACAVNGSARGGDLRYVGVTSTPGAEDPVVAFGIAMWGQWYTLGSVASPGVRIDTTGDGEPDFAVTAVKPTDPGGSVKADVWLARTTRLADRATVDERPLNGAFGDVDTNLMDSDVVVLPVGVRALGVDPAAGSARISYTARVTGAYAPPGTTDNVIDTLDVPMSFDVLRPGFAVLSYGSAVLSTVVADGAEFEVRRDDGALAADGSDSLLVLFHHNGAGRRAEVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T962</accession>
    <name>A0A7W7T962_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">F4559_006232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="27895" checksum="77E9B7F5157E3D23" modified="2021-06-02" version="1">MLLAIDVGNTNIVLGLYEGSGDKAELLRDWRMRTDARMTADELALTMRGLLGEYADKITGISALSTVPAVLRELRVMLGRYYSSVPKVLVEPGVKTGVPLLVDNPKEVGSDRVINTLAAHHLYSTACVVVDFGTSTNLDVISAKGEFLGGALAPGIEISVDALAARAAQLRKVELVRPRSVIGKNTVECLQSGIVYGFVGQVDGLVRRIVDELHATEPGDVTIIATGGLAPLVVSESATIQTHVPDLTLLGLRLVFERNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A3</accession>
    <name>A0A7W7T9A3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23108" checksum="57C2557F04BF2D1F" modified="2021-06-02" version="1">MGQYVLPDLDYDYGDLEPAIIGEINELHHGKHHAAYVKGANDTLEQIAEARDKDAYGSIVGLETTLAFHLAGHALHQVWWKNLSPNGGDKPVGELAAAVDEHFGSFDKLRAQLTAASGTIQGSGWGVLAWEPVGQRLITQQLKDHHSNLSIATTPLLVFDIWEHAYYLQYRNLKADYIGALWNVVDWNDVSARFEAARAGKNGLQLPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D1</accession>
    <name>A0A7W7T9D1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="13895" checksum="296D77EDA8CBBC61" modified="2021-06-02" version="1">MDTRPAYQQIADDLRRHIASDEANIGDKLPSLSELTAKYGRAVMTVQKALDQLRAEGLVVSRQGEGTIITGKPEAHAADHVPSPHELRTMFERINNALDDLSRRVAVVESELFGPPSSDPRPGPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9E8</accession>
    <name>A0A7W7T9E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette subfamily C protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_005771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="261"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="299"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="515" mass="53728" checksum="2E4688941610FEAC" modified="2021-06-02" version="1">MKRLVTAVLAGVAAELAGIGLTVTAVWLILHAAQQPPLASLTVAIIAVRTLAIARGTLRYAERLAGHDAVLRFLVEARGRVYDALVRRPVPGGDALTRLVSDVDALQDVVLRCLLPAAVAAAVGLAALIATGFALPLVIGLAGCGALLPFAAYRWSTTRLRDLAPVRADLAQRTVTLLDGAAELTAFAALDRELDATGEVVDTLARKEKLGSLGTAALGGLAVVVQFGTAVFLLWQGEPGHVVLGAVAVLEMTIPLTAAAHRFAEVRGSLDRLRETLAAQAETPVTVPLPPGRRTAIVGRSGAGKTTLLDAIAAAHPGVAKGALADSHVFHATVRANVVFAAPDATDADLDRVARTVDLDVPWDTVVGEHGTALSGGQRQRLVLARALLADPDVLLLDEPVEGLAVDHGDEVLARVLDAARDRVVLVTHRLAPLVDFDEILVVEDGVVTRRGTHAELLAVPGHYRDRWHTERSGGRSATSTSTGSGTHSPATGTNRVSVSDVVGTPQRRSTVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G0</accession>
    <name>A0A7W7T9G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10916" checksum="C56CAD5D5A8CBF59" modified="2021-06-02" version="1">MDRTLQNFDARFRAAEDRLRGARDRFAAAGFELYAEGFDRMAYYRDVVGAETALAEVFAEARMSVRVGGVVWSALYDAERLHRNYADECRRLLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H5</accession>
    <name>A0A7W7T9H5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion-transporting ArsA/GET3 family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="39433" checksum="51FDFBF110FAEFB3" modified="2021-06-02" version="1">MNRLDVDALIDDPRTRVLVCCGSGGVGKTTTAAALAVRAAGRGRRTVVLTIDPARRLAQSLGLGELDNNPRRVAGVDGELHAMMLDMRRTFDDMVLQHAGRERAEQILANPFYQTISTSFSGTQEYMAMEKLGQLVARDEWDLIIVDTPPSRSALDFLDAPQRLSTVLDGKLIRMLSAPARAGGRGIRKIVGAGFGLFTKAVSTIVGGQLLNDASTFVQAFDSMFGGFRQRAQATYELLRSPGTGFLVVAAAEPDALREAGYFVERLVTEGMPVTGLVANRTHPVLAPLPAAGALAAAERLERTGDAPLAAAVLRVHADRVAVADRERRLLARFTRAHPGVPLVGVPALPADVHDLDGLHEIGHRLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA67</accession>
    <name>A0A7W7TA67_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="472" mass="52265" checksum="ED843CDF2AE82F5E" modified="2021-06-02" version="1">MSVTREAAPPTPADTGPAPERFGFAAAAVVVILCGLTLFLGFLNKDRCTGPEFDPWGRSTPNYEERNKGDVCYSDIQHLWIGRDIDRHVFPYVDGGITEQGALVGGTVEYPVLTGVLIWLGAIFADTDAEFLLFSSILMIPFGIGAAYMLGKLSRWRALIWAIGPPIVLYAFHNWDLPVVASAVAAVYVMARGWGRTPRTFQQRAVVASVFLGIGFAFKLYPAVFVLPLALMALTGGEDGRELPADRKYDWVAASRVALAAIVTAILVNLPFALVGFEGWRASFTFQQLRNVDITTNSIWFWGLRPFMSDEALQSISDVASPLTMLLSFALACWLGWRRFQRTGTYPWVQVSGAMLCGFLLLHKVHSPQYTLWLVPMFVLIRVHWGWVAAYFTADLAMGIGIFRWYYAIQFGHPSGIYDGLSAQAVVIGVWGRAALLAALFFVFIKSEVTFDVAKYLPGKDRHRKEKAPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA91</accession>
    <name>A0A7W7TA91_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylaspartate mutase epsilon subunit</fullName>
            <ecNumber evidence="2">5.4.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="633" mass="67824" checksum="5D317D5B6B67F410" modified="2021-06-02" version="1">MSRAALGAELDVAVVGAGPRGLSVLERIVVRSAGRAGRVRIWLFEPGEAGAGRIWRTDQSDLFLMNTAAGEVSAFSAAADDGPVRAGFGPSFAEWLAAHPDRSDLGPNDYAPRPVYGEYLKYAYEAIVRNAPAHVTVHHVTESAIRLHRRDGRSVVVGAYGTEVVADKVVLTTGHPGNRPDETEVEFLDFAAATGTRYLRGDSAADLDLDAIGPGEQVGVIGLGLTFFDVMAAVTIGRGGRFTADGYLASGREPHLVAGSRSGLVMLARGRNQKPPDYRYRPAIATPEAIVAARRAAQRVDGSAQLDFREQVLPLLRLEVDHVYYTGHVRLRYGAQAARLFAERHRALRATTPELLAEYGVADVEPVDLAALARPFGDRAFTGPDHFHAELLDLLGRDIAHAHRGNVDDPLKAALDILRDIRGSVRQAVDFAGLRPRSHQDFLTWFNPINTMVSAGPPAVRVAQACALIRAGVLTVIGPGTRITTGADAFELYSPQVAGSRRVVTTLVDARIPRPDLRANADPLMGRLLSDGLVTDLVNTDPVSGDRFTGGGLAVTRAPFHVIDANGVPDPDLYALGVPTEDTRWFTQIGNGRPGPLTGFHADADALAVDVLDTGRAVVVLTAWTRTFADTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAI5</accession>
    <name>A0A7W7TAI5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="4">6.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="103"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="548"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="653" mass="70714" checksum="1405100E3CD57F0C" modified="2021-06-02" version="1">MTDTRAGAAAGEAEPLWRPDPDRVSDSRMVSFRSWLGTTKGLEFPDYPALWEWSTTDLAGFWGAIAEYFEVSFHTPPEAVLASDAMPGASWFPGATLNYAEHALRHDTDELAVVFHREDGVSSQLTYAQLRERVAGVRAGLAGLGVGRGDRVVALVPNSPEALIAFLAVASLGAVWSSCSPDFGARAITDRFAQIEPVALIAVDGYRYNGRGFDVRPVVEALRAEIPSLRATVLIDYTGGTLPGVVAWDELPVPDVPLSFEPVPFDHPLWVLYSSGTTGLPKGIVQGHGGIVLEHLKMLALHSDLGPGDRFFWFTTTGWMMWNYLVSGLLVGTTVVLFDGSPAYPDLNVLWHLAEQHRATYFGTSAPYIQSCLKEGLEPAKRYDLTALRVVGSTGAPLSPEGFRWIASAIGGDVQIASVSGGTDLCTAFVAAAPDLPVWEGELSCRALGASVHAYSEDGRPVVDEVGELVITKPMPSMPVFFWGDDDGTRLREAYFDDFPGVWRHGDWIRITPRGSAVIYGRSDSTLNRGGVRMGTSEFYRVVEGIEGVADSLVIDTSGAANPDGELLCFVVLDGVTLADVEPDLKRELRTQLSPRHVPNRFVVVEEIPRTLNGKKCEVPVKKILAGTPPERAVSRDALRNPAALDPFLALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAS1</accession>
    <name>A0A7W7TAS1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="PTHR11056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="43041" checksum="22B9A5D3699A2057" modified="2021-06-02" version="1">MAYYRQVGEIPRKRHTQFRTPDGGLYAEELMGVEGFSADSALLYHRHLPTAIVDAVTVEDDRGGLVPNLPLKPRHFRTPDLTWDKADAVTGRRTLFGNPDVTIGFVVATEPSPLYRNAAGDELLYVQSGEGVVETIYGALTVGEGDYVVLPTSCTYRVVPDSPLSLLVLEAGGHIGPPKRYLSKQGQFLEHSPYCERDVRGPTEPLLVDGEDVDVLVRHRAGLTRFTYANHPFDVVGWDGHLYPWVFNIADFEPITGRVHQPPPVHQTFEGPNFVVCSFVPRKVDYHPLSIPVPYNHANVDSDELLFYVGGDYEARKGSGIKLGSLSLHPAGCTHGPQPGAVEASLGAERFEELAVMVDTFRPLDLGEAALSSEDPRYAWTWARRGPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAV0</accession>
    <name>A0A7W7TAV0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021607">
        <property type="entry name" value="DUF3224"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023159">
        <property type="entry name" value="SO1590-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11528">
        <property type="entry name" value="DUF3224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159238">
        <property type="entry name" value="SSF159238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="12447" checksum="1C891B47DF7E9C92" modified="2021-06-02" version="1">MEAEFDITRWEETVLDATEPPIGRVGVGKTYTGVLAGTSTGELTTCQAGDAGAGYVGTERFTGTFDGRTGTVVFQHGATMSPAGPVQFGHVVPGSGTDGLAGLTGSVRLDHGRITLDLRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAX6</accession>
    <name>A0A7W7TAX6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18676" checksum="82F4C236A61410EA" modified="2021-06-02" version="1">MTAATRDRRSEPEDDDLHSVRWNDRALFGTFRGLPWWAAVAGTFVLAIVGTFLDLSADSAVGWVFAVTFFVGAVGSVVFVERRSMFGPVVEPPLVLAIVVPLVVVLTQGLPTGGLASVGLKLGKPLIDGFPAMAVTTACTVLLGLYRVIKQRDPNRPTADEVRAAKRRPRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB32</accession>
    <name>A0A7W7TB32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030663071" evidence="1">
        <location>
            <begin position="31"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="13983" checksum="CFFEF3B62DBB0F45" modified="2021-06-02" version="1">MIESKRVVRTFAVVAAAAGALAITAGPASAAPETTGCTASNLITSPSTRQVGWTVDCTDRRYVFADITVFSGGSVSSNPQDTKWVNAGDSWQNLNTYAQTNPAIDHLCVHLVTYVDPTNPFDQPVVIGHQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTB2</accession>
    <name>A0A7W7WTB2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10497" checksum="417DE85CCC82954D" modified="2021-06-02" version="1">MFGIPTRGLLVIGVLGTAGLLYLGKGVESTPREAASCRVAVVADVLNVRSGPSDAQPVVATLRRDAVVAAERQVVDGFRLLGDGRWVKDEYVLPTSDSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTH3</accession>
    <name>A0A7W7WTH3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="408" mass="43982" checksum="2E2E364ED4322112" modified="2021-06-02" version="1">MSVRVELLHNAVRPYAWGSRTAIAELLGRPVPTPHPEAELWMGAHPGDPSHVVCPDGGRRSLLDVLAGDPDGQLGAACAQRWGSRLPFLLKILAAEEALSLQAHPSAEQAASGFAAEDRAGVPIDSPIRNYKDPSAKPELICALTEFHALAGFRDPHRTATLLTSLEAPDFAPYARLLAAQPDADGLRALFTTLITLPQTALDVLLPQVLDACVLHVKEHGEFDAECRTVLELGEAYPGDAGVLAALLLNRLVLRPGEAIYLPAGNLHAYLHGTGVEILANSDNVLRCGLTPKHVDVPELMRVLDFRCGDMEVLTGEESAPGLWTYRTPCPEFELSRVELESGLEVRVDHGGPQIMICTEGRATLTTVRGDRLVLGRGESVWLAAHEPAVLVHADERTRLFRATAGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTL6</accession>
    <name>A0A7W7WTL6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRSO17 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="47198" checksum="E540BB5855F76617" modified="2021-06-02" version="1">MVWSPAAVTPEEMAEVRPVIEEFAAGVFGGFARRDQRGKGELYLRGLLLDGKRKSMQPMAERLGVDHQQLQQFVTTSTWDHVEVRRRLAVWAAGFVDPDALAVDDTGFPKDGTSSPGVARMYCGALGKRGNCQVGVSVHAVTDWTSAAVDWRLFLPESWDDAKADDESAAAEIARKRARCSIPDQVRHREKWRLALDMIDELLGWGMPRRPVVADSAYGDSTAFRQGLTDRGLTYAVAVSASTSLHPATSAPVPPGWSGTGRPPTKTTYPDKPVTAGTLVTEAGRSAGRFVLWRHGSRTSAGNPAATMRSRFLALRVRPANRNIPRAADGSLPECWLLAEWPTGEPRPTDYWLSTLPPDIRLRDLVKLAKIRWRIEHDYRELKDGLGLDHFEGRSWLGWHRHVTLASVAQAICTRLRRTPKAPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTL9</accession>
    <name>A0A7W7WTL9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein F4559_000211</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17916" checksum="E4BEEC034CB90E91" modified="2021-06-02" version="1">MADPSFDVVSKVDRQEVDNALNQASKELGTRFDFRNTGAQVAWAGEEAIAFQAETEERCRAAVDVFQEKLVKRGISMKAFEVGDPAISGKVFKVTGSLVQGISSEKAKEIAKKVRDEAPKGVQAQIQGDQLRISGKKKDHLQDVIALLKNSDFGIALQFTNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP8</accession>
    <name>A0A7W7WTP8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="43799" checksum="074088A26677FAD0" modified="2021-06-02" version="1">MIGHTDNSILIDAPLALVWSATNDVANWPELFSEYASAEILSEVDGTTTFRLTLHPDDEGRVWSWVSERTPDPVTRTVRARRVEPGVFEFMEITWEYREVAGGVLLRWVQDFRVRPDAPIDDEAMTERINRNTVTQMGLIKERIEAGAGPLPADFGLAGRRVLVTGGTRGIGRGIVRMLARAGADVLTCYRDDEAAARSLERELKGLPGTHHVVRADLSKVEDVERLVDECEVRFGVLDAVVNNAGVISHLPYRELPVREWQRIIDVNLTAAHLVTQHTLPLLSPGASVVFIGSKVAEVGVPLRAHYTASKAAVVGLALSLAKELGPQGVRVNVVAPGVIETEVLHAMPRDARDGLRARYREKTALGRLGEPDEVGGAVLFLVSPLSSYVTGEVLHVGGGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU4</accession>
    <name>A0A7W7WTU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator YiaG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="21170" checksum="BA08C615D3831658" modified="2021-06-02" version="1">MPKHIPEVPLFDPAALTHHRRRNRLTQVELARRLAVHDNQIYRWEKGITPIRATELRRLAAQLRLHPAQLQRRLDAPPTLTDLRSLRALTRQELAHRLHIRLHRLTAWENGRLGPEQGPILAAHLDIGDQAVDVYERTGRLPAAITHRLARALRVTTALAEAAFHNSRTTGTHRGSPTTAIRTPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU34</accession>
    <name>A0A7W7WU34_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14361" checksum="1FEF0809CED35671" modified="2021-06-02" version="1">MTQGGHDVLDLDDDTPIPLAPIEVSVFGRVWTVRREWTPADAMRYWVLAHRRKDAEAMALLVGDGDAAAFAEIIAAVPLERSQGKLRRLLKIAGLLARDAQDEESEGKSSATSPPPGEDGGTHSSPTSDSGTGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU85</accession>
    <name>A0A7W7WU85_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">F4559_001384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="35"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="581" mass="63009" checksum="3B5EDA22C8F37A70" modified="2021-06-02" version="1">MITRMSSLFLRTLREDPADAEVPSHKLLVRAGYVRRVAPGGYSWLPLGLRVLRNIERIVREEMDAIGAQEIQFPALLPKEPYEATNRWTEYGPNLFRLKDRKGADYLLGPTHEELFALTVKGEYASYKDYPVTLYQIQTKYRDEARPRAGILRGREFLMKDSYSFDLTDEGLAESYAAHRRAYVAIFDRLGMEYVIVSATSGAMGGSASEEFLAVAPTGEDTFVRSTGSDYAANVEAVVTPAPAESDPAARPEARVVHTPSTPTIDSLVEFLDGLGERTFTAADTLKNVLVKTRAPGEKDWTLLAIGLPGDREVDLKRLEAALEPAEVSLLDDADFARNAFLVKGYIGPGALQANGVRYLTDPRVVRGTAWVTGADKADHHVVDLTVGRDFTPDGVVDVAEVREGDPSPDGEGVLVAARGIEIGHIFQLGRKYADAFALDALGPDSKPIRITMGSYGIGVSRLVAAIAEQSHDDRGLVWPRNVAPFDVHVVVAGKDETLLAGGEKLAGELSAAGLDVVLDDRKASPGVKFADAELIGVPTILVVGRGLANGVVEVKDRRTGDRVEVPVDDAVRHLLDVVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK0</accession>
    <name>A0A7W7WUK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14847" checksum="F09044F9D8DE4E16" modified="2021-06-02" version="1">MLADLARYPLWWREVRAAEQVGERAARLRCRSLLPYDLVFETHHDTRDRVAGVLKARLVGDLDGTAAWRIRPSGTGTLLRYEQEVTVTKPLLRRLALVARPALVANHGLMMRSGNRGLRTYLAGYQAGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL0</accession>
    <name>A0A7W7WUL0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ORF">F4559_001743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="15"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="365"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="463" mass="49212" checksum="491F9BEEDABF8FF0" modified="2021-06-02" version="1">MSSLWGARFAGGPADAMALLSASTHFDWRLAPYDIAGSRAHARVLHRADLLTTDELDRMLAALDTLAADVASGAFTPTLADEDVHTALERGLIERAGPELGGKLRAGRSRNDQIATLFRMWLRDAARRVTSGVLDVVDALVAQAEAHPTAAMPGRTHLQAAQPVLLAHHLLAHGQALLRDVDRLRDWDKRAAVSPYGSGALAGSSLGLDPAAVAADLGFDAPVENSIDGTASRDFAAEIAFVLAMIGVNLSRVSEEVIIWTTAEFRFAVLDDAWATGSSIMPQKKNPDAAELARGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPLFDSVEQLELLLPALAGMIATITFDTERMAKAAPAGFSLATDVAEWLVRQGVPFRLAHEAAGGCVRVAEGRGVDLVDLTDEEFAAVSPALTPEVRSVLTVEGSIASRDAYGGTAPDRVAEQLKRLRDKVSVARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV28</accession>
    <name>A0A7W7WV28_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7023" checksum="7D4D4549FA9A5818" modified="2021-06-02" version="1">MSGGVGIRWGERRKPRRSQGANNCVEIAHAADLVGVWDTKHREAGPVVVGRRAWAAFLATGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI2</accession>
    <name>A0A7W7WVI2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030624023" evidence="2">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="20946" checksum="55D0C2A96543A28B" modified="2021-06-02" version="1">MPSSASCCRAVSCPLVVTLIRSTTPCNPLRLVQQTRSATAVEPWVVERLHPVRGPRRCGGGRGLGNRSSVDHAGRRGAGAPGRRMEGIGFSAAAQGWPTTGRLRPAICGRPSHAVAAGERAFDMWSSKSVLTGVDIRVRVCVVFSLLRAKCSGTGDDELPVGSTARRPDGTGPVGEPTPCQWVRGRSADGIGVTVPVPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI3</accession>
    <name>A0A7W7WVI3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coproporphyrin III ferrochelatase</fullName>
            <ecNumber evidence="8">4.99.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cpfC</name>
        <name evidence="10" type="ORF">F4559_002296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:49572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="EC" id="4.99.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:49574"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 9">Porphyrin-containing compound metabolism; protoheme biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00252"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Fe-coproporphyrin III</name>
            <dbReference type="ChEBI" id="CHEBI:68438"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="36704" checksum="975019D5A2BA0A52" modified="2021-06-02" version="1">MSYDALLWLSFGGPEGPDDVRPFLENVTRGRGVPPERLDEVERHYLHFGGVSPINALNRAAIAAVEPLLDLPVYFGNRNWHPLVERTLAEMKDAGVRRALVFPTSAYGGYSACRQYDEDVERARAAVPDAPELVKLRQFFDHPLFVDSFADAVRSAATPFGDDYRLVFTAHSVPLSADAAAGPPAEGGHRYSRQVAEASRLVASQVGVAEYDVVWQSRSGPPQVPWLEPDIVDHLDVLHAKGVANVVVCPIGFVSDHLEVVWDLDTEARDRAAELGLGFGRAATPNGDPRFAQLVAELVAEHVSGAPARKLSDFPAAGCTVNGAPCAPLCCEPARRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU5</accession>
    <name>A0A7W7WVU5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030708615" evidence="2">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7336" checksum="5FDF52EB9DED1F48" modified="2021-06-02" version="1">MKNLLKTAAFLSAMMMVLPMVHPGTTNATSSERSSPASAKLRRCPTDGLVSLDLRRSVRVVLPAAKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW61</accession>
    <name>A0A7W7WW61_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase (DIM6/NTAB) family NADH-FMN oxidoreductase RutF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17119" checksum="AD038CC26157AD38" modified="2021-06-02" version="1">MSVDVHTELGHHRLRAAFGTFPSGVVAVAARVDDGIVGLAASSFTSVSLDPPLVSFSIANTSATWAALRRADHVGVTVLAEHHDVVARQLAGPAAGRFAGLDLTVGVGGAVTLADGVAWFDTTIDRHVEAGDHTIVLLRLHAVGHVDDPLPLVFHRSGFGLKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW88</accession>
    <name>A0A7W7WW88_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="9" type="ORF">F4559_003469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="13"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="407" mass="43536" checksum="06801FEBB631385E" modified="2021-06-02" version="1">MPEHVAVVGLGFGDEGKGAVVDALCAARETVSVVRFNGGAQAAHNVVVGDRHHTFSQFGSGTLAGVPTLLSRHVLVEPIALATEARELAALGVPDPLRLVSVDRDALLTTPVHVAANRAREDARGADRHGSCGKGIGETAWYALLPGHGPGDVVEGWPLPGVPGPAPTVGDCADEATLRRRLDALAAFYAPLTEDFPAVDDMVHLYRAFADAVRTVDGDEVRRRAARGRLVFEGAQGVLLDQHHGFHPHTTWSTVTPDLIPAMLGERPRVLGVTRTYQTRHGAGPLPTEDPALDLPERHNGYGHYQGGWRVGHLDATLLDHAVRACGGVDALAVTHLDRTGLSVRTDTGLHALPRDVPGWFERRYGVPVRVTGTGPDRVDYAVRVREAAPADRGREFPDDRVDVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ2</accession>
    <name>A0A7W7WWZ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="PTHR10412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="857" mass="95897" checksum="A672EC5054252F9B" modified="2021-06-02" version="1">MTGAERRRLHDAERGTPWRRWGPYLADRQWGTVREAYGGDAWTSFTHDQARYRAYRWGEDGIAGISDDAQRLCLAVTLWNGVDPILKERLFGLGNGEGNHGEDVKESYFHLDATPTASYLRMLYRYPQREFPYQDLISTNRERGRDEPEYELADTGVFADDRYFDVVVEYAKAGPDDILMRITAHNRGDEDRTLHVLPTLWFRHTWSWAGGADRPHLRATAPGTVVAHDPELGRRSLVVDRAVPVLVTGNETDNERVFGSPNESPYVKDGIERVVVHGEPGAVSPDDEGTKASAHCALDIPAGHSATVRVRLTDGPPDHEAAFSGFDTIVATRRAEADEFHVEVAGADLADDERTVVRRAFAGLLWSKQFYALDVERWLTERGVDPLADTSLPNHQWRHLVAEDVVAMPDKWEYPWFAAWDSAFHAAALAAVDPAFAKHQLELLLDRRYLHPNGQLPAYEWNFGDVNPPVHAWAVWFVYELEGRKDKEFLARTFPRLLRYFDWWLNRKDADGRNVFQGGFLGLDNIGVFDRNAALPTGGRIDQADGTAWMALFCQNLICVALELGEVEQAQSLLENLAWISAAAQHEGVGFWDEEDGFFYDVLRTPDGGRVPLRVRSVVGLLPLAAATVVDGEVRTRFPQVVDDAAAFLERHPAVANSLWGRGSQANGSGTVLFSLFDETRLRRLLARMLDEDEFLSPHGIRSLSRWHLEHPYVFTVDGQEHRVGYLPAESDSSMFGGNSNWRGPVWFPINVMLIRALLHLHVHYGDKFTVECPTGSGRHLTLRQVAGEIGDRLFSTFLPDDSGVRPSDGGGPEDPALFHEYFHGDDGTGLGAAHQTGWTATVALLPALLRGTGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC1</accession>
    <name>A0A7W7WXC1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="30086" checksum="585E0E90AAF6457E" modified="2021-06-02" version="1">MSDERRMAANERNWNARTPIHAASAYYARDPESWFAPFEWADLGDVAGLDVVQLQCHLGTETQAFARRGARTSGLDLAGAAIAEARRLAAEAGVVVDYRHGNVYDAVSVLGGGRFDVVYTSKGALCYLPDLARWARVVADLVRPGGFAYVVDFHPVLWSLGLNPEPDEALLVRYDHLEGRGAVERDFVRTYTDGPPLPSDRTHYEWSHGLGELVTSLARAGLRVDLVRETDLLPWPRWSRMVRQESGWYALPPDEPRIPLVYAVKATKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR8</accession>
    <name>A0A7W7WXR8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031093998" evidence="2">
        <location>
            <begin position="41"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="24911" checksum="0839E2AAA1F8753E" modified="2021-06-02" version="1">MIRTCAAEWSRLWTVRATWLLLGVAAALMVAVGFITGSEAADRPPTGASAWTAASFAAMPAQFALLTLALLAVTSDYATGGIVPSLQWTPRRGVLFLARTTTAVVTAAVLGVLAATASTLTAHLVAGPVLPLDGVGEALPKVAVVFAAGAALAVGLGFLARGTAGALVVVFLAMLVLPLILRNFGYEWSTAVADVLPGSGVVSLLLQEIPGMTTTRSVVTLLCWAVGALALGWVRFAKDDANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY22</accession>
    <name>A0A7W7WY22_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="28879" checksum="8952E4DF34F454EA" modified="2021-06-02" version="1">MPASHFVPHYRADGPVRAGIPEHGRVPRYYAVKTELLWLVEALGEGTALPSERELAERFSVSRVTLRQAVGELVLEGKLQRRQGSGTYVAPPKLVQPLSLVSYTEGMRRQGVDPARSVISVEHLPADDVLARDLRIERGAPAIHFERVLLADDERVGLESTYLSADRFPTLLDAFDPTTSLYACLTEKLDVTFEEAEERVETVLATPREALLIGTNPALPMLLLHRVSYDNVGEPIERVRSLYRGDRFSFIARLRADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY62</accession>
    <name>A0A7W7WY62_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12054" checksum="64C5CDF77DFBEA35" modified="2021-06-02" version="1">MSDCLFCRIVARELPATVVHETDTTLAFRDIAPQAPVHVIVVPKIHATDAVALTTTAPGVLDDLFRTAGEVAKTENVADSGYRLLFNTGVEAGQTVFHAHLHVLGGRRLGPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA4</accession>
    <name>A0A7W7WYA4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6910" checksum="BA1A08FF35B4DDA0" modified="2021-06-02" version="1">MSRPETDGSEQYGWVYTEHGSVVLSVPGQRELRFSPDDARVVGELLIKNASDADQRITSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE2</accession>
    <name>A0A7W7WYE2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cellulose synthase/poly-beta-1,6-N-acetylglucosamine synthase-like glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="51230" checksum="3C17C1133D951749" modified="2021-06-02" version="1">MAGDPAVNLDVVLGFTQALALTMSVAFVTYVLLIVVPYLRRTPAPTGRAAAFEWHFMVPCRDEAAVIGDTIRYLRTTFAIAHVWVIDDDSDDATVGVVRSFRADKHVHLVRRYRPLARTGKGDALNDAYRTLKQWMGRHADLDRAVIVVVDADGRPAPNCLDVCAADHLFGDPGVGAVQVDVRMVNTGVRQAGVTSWRSRFGAFLVRMQDLEFRTAIAAIQLSRGVTGTISMGGNGQFTRLSALDTIAGHAGQPWRGSLLEDFELGVHLLTAGWRTGFTLDTHVHQEGLYSLRRFLAQRTRWGQGTMQCMRYIKRIWDSPHLSTLGAAEMLYYLAQPWMQLLGTLIYPIPMLLLAHRFVVDPGEVWGWFTGGAWVLFTVYGLFGLLPFVLWGPVYRARCEPGTGFVRALAYGFGYALYIYTFYITSWRAVTRLVRGRNGWTKTRRNTERVVGKVALDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK8</accession>
    <name>A0A7W7WYK8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22581" checksum="09AAB390CFD467FF" modified="2021-06-02" version="1">MTTTVTDTHSRSLHVPYITAWSAEQTEPHDLVALPGNTGIGYRDERPRDRDHNGVLWRRVPLARNQGKPLFGVVHSPRQRRAMHKLLCQVCAHPADTDPDGTLFVLPDHRTDWADWPEGMACTEPPVCADCLTLSTRLCPALRRGHAVVRVRNAPIVGVHGALHIASPTGVRAWKPTIVTFDDPALSWVLASHLVRELRDVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ6</accession>
    <name>A0A7W7WYQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021678">
        <property type="entry name" value="DUF3263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11662">
        <property type="entry name" value="DUF3263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="11263" checksum="58637988D7EC848A" modified="2021-06-02" version="1">MDAAEALAPAEKPDDGLTDREREILAFERQWWKYAGAKEQAIRELFDMSGTRYYQLLNALIDKEAALAADPMLVKRLRRSRSGRQRARAAKRLGVENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY5</accession>
    <name>A0A7W7WYY5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">F4559_005820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="34548" checksum="208F7F28D3E18AF3" modified="2021-06-02" version="1">MDKRVLLAKPRGYCAGVDRAVVTVEKALEQYGAPVYVRKEIVHNKHVVETLSARGAIFVDETDQVPEGALVVFSAHGVSPMVHQEAAERSLRTIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVEGTAGEAPEHIQLVDTAEDVDKVTVRDPSKVVWLSQTTLSVDETMVRVRQLQERFPELQDPPSDDICYATSNRQTAVKTMAPECDLVLVVGSKNSSNSVRLVEVALQSGAKASYLIDYAREVDLAWLDGVSTVGVTSGASVPDILVMELLEFLASHGYGEVEEITTANEKIAFALPRELRKDMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ45</accession>
    <name>A0A7W7WZ45_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="423" mass="45893" checksum="B4DB3F4A3231A8B0" modified="2021-06-02" version="1">MVRQPPSRTRLLRAGRDALLSAGSRILAEGLTIEAIVERAHLTTTTFYNNWPNKDRFGLVGGKEKFLDDLLGTLADGTAYAPLVFPGGTGDPRRLVRDRALQDFRALCADPAARARLFLATFARGHTAALRSARVEYRELSRRTAQACEATLAEWGAVLRKPFGPDSLAVVLTALVEGLALRRVLDPASVPDDLFGDAAVALLGAVVDGGQRDEHVDDVIAPLAEEVSREFHPDRLPDDPEQAVVDAAAHEFAHRGYHGTRLAHIATTAGVDLPTIKRLFPTKADIVAAGLRPSYDEVRKRLSTDVRLERPAPEILVRHLERLALATTAHRAMFDALMVLSTQDDTAREHVPNFPALVTPVIEEGQHAGRFTTALPAAELAALLTDTVLVRSFRRRDHAPTEVTNAVTVLLSGVLNGSPHAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA8</accession>
    <name>A0A7W7WZA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13102" checksum="C9EE1F863C5DBA7A" modified="2021-06-02" version="1">MTFGTEPVGSASETDVETTTIAEELLDQALAERRALVRLCLYALDRARSSGVVERIEEGLADVGVTAVRPDGERFDPSRHEAGGTVPTDDAALAGLVAETEVVGFVDRGRTLRAPIVTVYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE9</accession>
    <name>A0A7W7WZE9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="33808" checksum="F2798C2712D80371" modified="2021-06-02" version="1">MARVFVSYAMKDRFVARDIADRLTRLGTDVWTSDQLEIGDDLSSKIEQELAAASVLVVLITRDSLRSHWVTSEWTRAMADAKRVIPVLYEVSFDELPPGLATRQGLKVENGDIDGVARSIHEVVSRMSSAPAPKLAEDSRALVVRAAVEEVLADLGYRPGVPKVEEGPVVDDKLVFVVISYEEKMEPVYEAIEAAASAVGLKALRLKDVHDDFRITEQMLKMIREARFVVADLTDEKQNVYFELGYARGLGKKVITIAHQQTKIHFDVYDWVYIPYLDSRPLERKLVDRFRIELERDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZF1</accession>
    <name>A0A7W7WZF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9083" checksum="C39EF11EA3ED3612" modified="2021-06-02" version="1">MSDQAAVTVTVRYFAGARAAAGVADEPVVLSGRPTVADVVAAVRRRHDPALGRVLDASSFLLDGMAVRDRTVVVPAGALVDVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZP0</accession>
    <name>A0A7W7WZP0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="95"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="429" mass="46468" checksum="69C6EE96965A7906" modified="2021-06-02" version="1">MLSTDDHAPLYDSEVARWVPLGIAGGFVAVEQNRLTRLLTSPNKRVRAVLGDFDPDGEALVISTPYVHTAEFAGRPVLNHRRPEWVELENKTTIDALWDELSAPRAPAEVMGLDFGALLAATARLDRGAGVVWSGDGPAINGGANFVRRVRTSQEAREAFGVLEPKCEFVRVMPFLEGIPVSVHGIVFPDGTAVLRPIEMVVPRRQGQARFLYAGCASHYDPPTRIREEMRNLARRVGERLRETVDYRGTFTLDGIATADGFLPTEINTRYGGAMVCFEDAVPQLPLALVQVALVAGHDLGVSSIEFEELLVSSADAYRQSSVNANVRAVNPTEVVERPVVFTEWSCRFAHPDEAPHGTLRLKPSPLGAKLELDFVADQLVPGRPVAALTVAAFALADQEWGTSLGPLEPAVAVDDDVAPALEPTAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZU6</accession>
    <name>A0A7W7WZU6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="387" mass="41613" checksum="30FDED7F5CD58642" modified="2021-06-02" version="1">MGNSFARVFGGNVHPQEVAQALQREAEGNIRELAGGRLLAPNHYKVLLGPQDHDRLAGDGQDELRITQPLEDSIREHLEESGWDTYGDVVVSLERSDALHTGQFHTSSSVDPDVKVASRRSAPPRTAGDGSMSQPPGYGQGQGQPGYDPYAQGGYGQQQQQGYDQGYGGQQQQQGYGQQGYDQGYGQGGGGGYDQGYGGQQQQQGYGQQGYDQGYGGQQQPGYDQGYGQQQQPGYGQQGYDQGYGGQQQGGYDQGYGGQQQGYGQQGYDQQGYGQQQGGYDQGYGQQGTPRQLNATLHLDDGSNRTYNLKQGGNVVGRGQEADFRLPDTGVSRRHLEITWDGQAAMLADLGSTNGTTVNGTPVQTWQLAEGDVVRIGHSSLVFRTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZV7</accession>
    <name>A0A7W7WZV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9433" checksum="D8EB328800951DF6" modified="2021-06-02" version="1">MHVLLPSATDEQPTLAPSKVGFVVSKAVGNSVVRHRVSRRLRHVLRDRILRLPEGTSLVVRALAPAATASSADLAQDFDAALRKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXK1</accession>
    <name>A0A7W7SXK1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="26976" checksum="2C4344F21ABD40E8" modified="2021-06-02" version="1">MNPITDLAVNGPLVLATGLALVAGIVSFASPCVVPLVPGYLAYLAGLVGAEAPAVRADEDAKKGRFRVAGAALLFVLGFTVVFSLASFAVLGATDVLWFNEDVFQRVGGVITIAMGLVFIGLIPALQKDVRLHRRPRAGLLGAPLLGGVFALGWTPCVGPTLAGVLALARSTEVGSATTRGAVLVLAYCLGLGLPFVLIALGARWAVRVTGWLRKHTRHVQIFGGVLLILVGIALVTGVWGEFVGWLRDAVVNDLKLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYI5</accession>
    <name>A0A7W7SYI5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30789" checksum="D7268EA36E336251" modified="2021-06-02" version="1">MNDLEGRLRGAFEHQADQAPPAHTVLAAVGRAPRNTTRWLAAAAVVAAVVVGATALVDRPESVPLGTQPEATRVIDSGYRPTWVPDGYRETKRVIEDGVVTRIWSAEGLPRPTISVTTTRHEPGFPPLPDGMTRGVYLMAPEAWVLAEVENATDQDTVLQRVRTSLHRDPTPFHVPVEVVAGGPVVERTTLYAGRDGHWAVEARVGGRFQVVYSDVEDPAGVVTWLTVKDPSGSWEATSYVVRRGPDRWVRVISAGTLAASEEELAAVADKLVLDPEPDFGWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ3</accession>
    <name>A0A7W7SYQ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000762</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="127"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="37700" checksum="72C1F32AB51EEBAF" modified="2021-06-02" version="1">MTTQTTSPRPLLELGTGFWASKTLLSAVELGLFTVLGTGPATEEQVREKLGLHPRSTRDFLDALVALGVLEREGDLYANTPATALYLDENQDGYLGGWMRQASSRLFLAWSGLTESLRTGRPTIGSDSQDYFRRLYENLDHRRAFISAMDAITNHIGPELAGKLDWSRHRDILDVGGARGNLSAYLLREHANLRCTVFDMPELRPLFDEHMAARDLTDRTDFVTGDFFAEPLPKADVLVFGHILHDWDVEQRRALLAKAFDAVRPGGMVVVYDRMIDDERRSNAVGLLGCLNLLLVTPGGSEYAVADCRRWVESAGFARTEAYPLVDGLETAVVGYRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS7</accession>
    <name>A0A7W7SYS7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpD family alkylhydroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16727" checksum="5674F575E9B0DCF7" modified="2021-06-02" version="1">MSISRLPNPARLVPELGQIGGALFKATGNGSIPQVTIGLVQLRAGQIVGSTYLTVLHTGNLRKAGEDEDRITAVASWRDTSSFTAAERVALALVEAVLTPNPYGERVSDELYAQASEHYDDQALATLAVVIGQVGFFTPLALIGKPVPGVSAAEQWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ15</accession>
    <name>A0A7W7SZ15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18323" checksum="255FEE188AA533A1" modified="2021-06-02" version="1">MTSALILIDVQRGFDNPVLGPRNNPDAEANIAALLGAWTGTLVLVRHDSVEPGSPLEPGTEGNTFKPVLDGVVPHLLFGKKVHSAFHGEVDLHAWLTGRGITEIVLAGIQTNMCVETTARLGHNLGYRVKVVLDATYTFDLGDLTADQLAQATATNLAGGRFAQIVSTKDVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF0</accession>
    <name>A0A7W7SZF0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF849 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019475">
        <property type="term" value="P:L-lysine catabolic process to acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008567">
        <property type="entry name" value="KCE_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37418">
        <property type="entry name" value="PTHR37418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05853">
        <property type="entry name" value="BKACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="24663" checksum="2A8319D777D4C5D3" modified="2021-06-02" version="1">MLQACLNGAREAHCHPALPITPDDLARDAAAVAELGVTHLHLHPRDVLGREVLAGPEIAPTVARVRSAVPHVEIGVTTGAWIEPDPDVRVELVRGWAALAAGRPDVASVNVHEDGWLAVAEALHAAGIGLELGVRDDAAARVLLAAGPPPGTRRVLVEIPADHRVAHAERLLDLLAVVDVPILVHGADDSAWPVLNYAVRRDHATRIGLEDTLSDPDGTPTEGNAALIGHASLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZK1</accession>
    <name>A0A7W7SZK1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="35513" checksum="5F77EEB0BB8E009F" modified="2021-06-02" version="1">MITADSFPTPHLALRTNNAAKRADVHAFACLQAAVAEHMRVRLADEFERAGHDHAARIAYLHDLYADLIRWRWELEFDRARTGGDTVRPGYLLPADHGRYRLSLRAGGPNYDRIGAFGRLRDAAVWSPATRTFDGGLSTPASEIMEHYGEQAERRFAAEAPRADELVTTVTLPGGATLPGNRIVRGAAAREVAEHLYARIRARRADTGQVETGGDPMYCVTADPDHADRMFTAALDLLAQAYLDHPDKALRAWQWARFLLYQSPRTKKGSDAVIRTFLVVVGAVVFGVPPVMERDADLRCMVLGQFHATDMFEDHRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J9</accession>
    <name>A0A7W7T0J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13668" checksum="BD0AA38336A8B77C" modified="2021-06-02" version="1">MLDTAGRHANADHFAGIAAECALKGILHEFLGATPNQRGLLEHPQMSGKKEAGHLPGLWSQLSAVATGRNAAQFAELISAPNPFASWDVAERYSDGTHISDQRSAEHLAAARNIIALYERAKIDGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K0</accession>
    <name>A0A7W7T0K0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="16736" checksum="FDCE92D3675DF95D" modified="2021-06-02" version="1">MRSLGPRTEVAVAMAILGVGAAVVTAMHLTWPEPSEPPLAYENSNGAVGGAELKPFGIDDVSGAPVELTPGSEGARLVRLTNPNAVGIVVASLKAVPGTPMDVAHNKVEGCPASVLTVVPMATPVAIPPDGSVDVEMVVSIASDVPAACKDLVFPLTYSGNAAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U8</accession>
    <name>A0A7W7T0U8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luciferase family oxidoreductase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">To bacterial alkanal monooxygenase alpha and beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019949">
        <property type="entry name" value="Luciferase_OxRdatse_group-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03558">
        <property type="entry name" value="oxido_grp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="34494" checksum="F88E8F65BCC88A87" modified="2021-06-02" version="1">MRLSVLDRSRTRQGGTHAQALRDTVTFAAEIERLGYHRFWVAEHHGVPGVAGAAPTVLAAAVAAATTRIRVGTGGVMLPNHQPLVVAEQFGVLESLHPGRIDMGLGRSVGFTPAVREALGHPKEDAEEFEPRLRELLSYFTGMAGVRGYPADGLRPSAFALAVGPGAATAAKLGLPLVIGTFKGVEPTAAAITAYRRDFRPGWTDEPYVIVSSTVAVARTTDDAWRLLVPEAWSMAYSRTRGEFPALRATEDVLARDMTPRERRYFEESLTGHVFGTPDEVADRLADLAERTGADELLVTTSTFDRAALLDSYRLLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T116</accession>
    <name>A0A7W7T116_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leader peptidase (Prepilin peptidase)/N-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
            <ecNumber evidence="4">3.4.23.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EC" id="3.4.23.43" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="17165" checksum="02146440BEF48A92" modified="2021-06-02" version="1">MRSIPSWTVRALPAAVLPLLLCPLLPVDRVPILVVLVCFGVPLAVVDLRCRRLPDVLTLPAYPVVAAVVVATGADVVRAAACALLCFGANLIVHRRHPDSLGGGDVKLSGWLGAALGTVGWQALPVAAALSSLVTLSLRLSPTQRGPTVAHGPGLVAGAWLAVAFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T127</accession>
    <name>A0A7W7T127_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">F4559_001959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="370" mass="39752" checksum="97950FE9E6B6FD8D" modified="2021-06-02" version="1">MTNAALVLEDGRVFRGDAYGAIGASLGEVVFSTGMTGYQETLTDPSYHRQIVVQTAPQIGNTGWNDEDDESRRIWVAGYVVRDPSRVPSNWRSKRPLDDELVGQGIVGISGIDTRMLTRHLRERGAMRAGVFSGDDLGSTEEMLARVLAGPEMTGADLAGDVTTPESYVVEAVGERRFRVAAIDLGIKSNTPRMMAARGIEVHVLPVSATFDDIASIGVDGVFLSNGPGDPATQAHAVGLTRDVLDRRVPLFGICFGNQILGRALGRDTYKMRYGHRGINIPVIDVATGKVAITAQNHGFALEGEPGEEFASDFGRVLLSHYCPNDGTVEGVRALDVPAFSVQYHPEAAAGPHDAAPLFDEFVNLMAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T153</accession>
    <name>A0A7W7T153_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030540457" description="Peptidyl-prolyl cis-trans isomerase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="20544" checksum="81F94A113C332122" modified="2021-06-02" version="1">MRTVDRTALVVASLLSAGLALSACTASDRPSTQTTTPVAQAPQTTQAAEETPAEEAQAVKPTGPPCATDAFKVQGAEGAQPTVTVPRDCSPLEGLVVQDITPGTGAAIAAGDTAEIHYTLYTFSDAKLQETSYKKGEPYPVVNVGNAQVIQGWNQGLVGLKEGGRRLLVVPPALAYGDRGSGAIKPGETLVFVLDAVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1I5</accession>
    <name>A0A7W7T1I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14316" checksum="4B1E4231DC69263C" modified="2021-06-02" version="1">MAERHASGVLDTCAYIDLELLDPAVLPEVPELTAITLAELHQGVAMAKDAAARAARIEKLGAAIVEFEPLPFDGQAAARFGTLVALTLDANRDPKPRRLDLMIAAIASAHDLPLYTRNARDFAGLDGMVEVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M8</accession>
    <name>A0A7W7T1M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="35213" checksum="C7DDA2FD7E8F24C6" modified="2021-06-02" version="1">MKLELRHLRVVCAIADAGSLSKASSLLGLAQPALTAQLHRIESLLGGKLFDRDHKGARPTMLGELVLERARVLLPAFSRLQEDALRLVDDSSPGDRYRVGSVNGPMLGGLVHRLTELHPGAHVSTQVSWSGDELAGAVAQGKLDYVMVGVCGDAPPPTEHGLTWSILAVDPVFVIVPEDHPCTAKEEVELAELKDMQWAVTPGDGCFGDCFVAACSRAGFTPRTMYEVDTNSCVDLAQSGDAVVLCQPMFRRTPGLVAMPIAGVPLKWRHVMGWDPEGPAAEFAGQVMRYAIDAYRETVERNPRYEAWLPTHPEYGPLDYHAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P4</accession>
    <name>A0A7W7T1P4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15456" checksum="F302613D397E6354" modified="2021-06-02" version="1">MTSRISMSMTMALDEDVTVGLRGSLGSSARLLIGDRIEIVLEEQHLRALHAQVEATVRDAALVKAADDVLDEAFHAASQARSAAERAREFSKSALTPVQIASALELARSADRAAQEAQRLVEEAATAMRSADEVAERVLALVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q6</accession>
    <name>A0A7W7T1Q6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9779" checksum="349ABA4B3BA1F588" modified="2021-06-02" version="1">MSRRRLPAALTTGRPRSDWRLWRACCDGREPAEALTTRDREDLVRLLWDCGWTDGEIAVHTRLTDYTAARIRTRLGLVANTLPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y0</accession>
    <name>A0A7W7T1Y0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9502" checksum="CF61BF2C562C3EB3" modified="2021-06-02" version="1">MERNRPARLSQQPVANVGGQTELVAAQDTTVSLWTILVGPRTTLTAESVVVDEATKRKWVVVGAVARRPEHHPKYLAAGARLISDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T293</accession>
    <name>A0A7W7T293_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13627" checksum="64EBF1670EC2CE30" modified="2021-06-02" version="1">MTAYDVVKGHYAASERGDLAGMLGVLADDATWTECDGTTYAGTYTGVEAIKENVFFKIGADWSSFAANVDELFDAGDTVIALGRYAGTHRATGKSMTARFTHIWKVADGKVTSFEQVADSSLILAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A9</accession>
    <name>A0A7W7T2A9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030844374" evidence="1">
        <location>
            <begin position="28"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="344" mass="34216" checksum="16645E0A40058DDD" modified="2021-06-02" version="1">MNTYRRMGAVVVAALAATVFGTGSAQAATTITVLAGLPGSTTTSASAINAAGVVVGTSGHTGGSRAVKWSTTGVVTDLGGPADALYIGASAVNRYGVAAGSATGTDGKPRPVRFGTDGTHTVLGTLPGYDKGAFATGVDDNGVVVGQASGRSYYNRLAVRWDANGVPTALPLPPGYTASSIGAISPNGIVTGMVYAYNTPLRAVRWNRDGTTTVLPTLPGGGGTTAASVNRYGDVVGTAIAADGNQHAVRWNRDGTSTDLHDGSPHRGYAVAINDSGVTVGGLLTADGATRPIRWSANGTALDLGVPAGVTSAIPSGINGAGVIVGSTGDDSSYTHQAVKWTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2G5</accession>
    <name>A0A7W7T2G5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17704" checksum="628086F968226B6B" modified="2021-06-02" version="1">MSPRTLLDRTGRLWQWNPTLSRRSGVPLGVFCHRGHRRTEQELENEAEPIIEVRDPRVLAVALEPVPARQIRLNDLVVLPGLGELSPVIGVWPCTDRYASLLYVCTDNGDWAHRPVDSLLLRADIRTPGRPAAPSIVPTSTISKSPHSPALQDEEPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2G7</accession>
    <name>A0A7W7T2G7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040964">
        <property type="entry name" value="SBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17882">
        <property type="entry name" value="SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SBD" evidence="5">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="14837" checksum="AF8A3357EFA1ED4C" modified="2021-06-02" version="1">MATYRTEIHTGGGGRQADQDLTIQISARSQVVPGSGAPSTGTTVTWSGDQGTAAITFFDGGSSFTGTARLPHAPGCSTESTRDRSTGHAPPPMEPSSPDRHETRLRAQPHRQTCAGLIKAPREPAGPFPPRRDVAPAPSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J0</accession>
    <name>A0A7W7T2J0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="8">IGPS</shortName>
            <ecNumber evidence="8">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpC</name>
        <name evidence="10" type="ORF">F4559_001529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TrpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="269" mass="28252" checksum="0127ED7DD44A8138" modified="2021-06-02" version="1">MTVLESIVEGVREDLAVREAELPFDVLRERAAKVAPPLDVMAALRAPGVGVIAEVKRRSPSKGQLAEIPEPADLAAQYELGGARAISVLTEQRRFGGSLADFDAVRAVVNVPLLRKDFIISPYQVHEARLHGADLVLLIVAALEQNALVSLLDRVESLGMTALVEVHTAEEADRALEAGASVIGVNARNLHTLEVDKDVFGRIAPGLPFDTIKIAESGVSGPGDLMAYAGAGADAVLVGESLVTSGDPKVAVNKLVTAGSHPACPRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L2</accession>
    <name>A0A7W7T2L2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="22180" checksum="E7AAB30A77452342" modified="2021-06-02" version="1">MTTPKEDLHNYLRVGREAILWKLDGLSEYDVRRPLTPTGTNLLGLVKHLALVESGYFGATFGRPFPREEPWMTDETELNIDMYAKADESREHIVGLYKEVWAHSDETIESLPLDAPGTVPWWAEDKRQVTLHRILSHVIAETHRHAGHADIVRELIDGFVGHRQGTDNMATHEESWWVSYREKVEQEARAAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2V0</accession>
    <name>A0A7W7T2V0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="20393" checksum="F7E990046D7E9AA3" modified="2021-06-02" version="1">MTSAPQTPILPPAAAAIERRHLRRLRLRPKAPATGHVDGAWWPCSRDLVTELPALLAVVAVRLGDVLRVSYALSEWNAAPRRLATDTRPVRLEGFHSRPAHTLDLVAADGHRLTLLVVPSNTDPTSAHRTMALAADRDNVQTVDDLLAAGIVQTVSNRHVSDLTYTAIARWEADGGRIPEQTNRCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I9</accession>
    <name>A0A7W7T3I9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative repeat protein (TIGR03847 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20801" checksum="9467C18CE67AED87" modified="2021-06-02" version="1">MARVIHVFRQPDRFVAGTVGQPGDRTFYLQAAEEARLVSVALEKQQVAVLAERIGSLLEEVHRRFGADVPETVPEDLRDTEPLAVPVEEEFKVGTMGLGWDAESRAVVIELLALTDEEIDEAVVLDDTEDGPDAVRVFLTPVEARAFAERADRVVRAGRKPCPLCSEPLDPEGHVCPRQNGYRRADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3K6</accession>
    <name>A0A7W7T3K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase HrpA</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="84"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="277"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1299" mass="145862" checksum="0CA3DFB7903BB002" modified="2021-06-02" version="1">MDTTQHADLRERLTGLMSRDQRRLGRRLDGARRVRDTSARAAVLAEIAQDLDRAELRVALRREAVPKITYPAELPVSARRDDIAQAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVVGQIGHTQPRRLAARTVAERVAHELGTPLGSAVGYKVRFTDQSGDDTLVKLMTDGILLAELQTDRTLSRYDTIIIDEAHERSLNVDFLLGYLKQLLPRRPDLKVVITSATIDPQRFSRHFADAPIVEVSGRTFPVEVRYRPIVDPDDTEADPDRDQTQAICDAVRELQAEGPGDILVFLSGEREIRDTADALGALDLRHTEIVPLYARLSSGEQHRVFQPHTGRRVVLATNVAETSLTVPGIKYVVDPGTARVSRYSHRLKVQRLPIEPVSQASANQRKGRCGRVSEGICVRLYTEDDFLARPEFTDPEILRTNLASVILQMTSIGLGDVAAFPFIDPPDARNVTDGVQLLQELGAIAADRELTPLGRKLAQLPVDPRLARMVVEADRNGCVREVMVIAAALSIQDPRERPSDKQQAADEKHARFTDPTSDFLALVNLWQYVREKQKELSSNQFRRLCRTDFLNYLRVREWQDVYTQLRQVAKTLGVHVNDDPADPRSVHVSLLSGLLSHIGLKDVPKRDAGKRQVTEYLGARNAKFAVFPGSALFKAPPQWVMAAELVETTRLWGRTVARIEPEWAERLGEHLVKRTYSEPHWDAKRGAVTALERVTLHGVPLVTSRKINYGRIDPVASRELFLRHALVQGEWTTHHKFFHHNRELLAEVAELENRARRRDIVVDDETLYDFYDHRVPADIVSTRHFDTWWKKTRHTTPDLLTFDRDMLVHDRVDITPDAYPDELRRGGLTLPLTYRFEPGERTDGVTVRLPLPALTTLPDDSLSWQIPGLRHDLVVALLRSLPKPVRRNFVPVPDVATAVLTRITEDEPLLPALERELRTATGITVDRADWHLDQVPDHLKLTFRVVDENDRELATGKDLGALKRTLQGRLRETLAAAASSLARTGLTAWTVGTLPKTVHEEQSGIVVTAYPALVDKGTTVAVEILDTPGRQQAAMWKGTRRLLLLTVPSPVKLLQRGLTNAEKLTLTRNPHGGVAPLLADCIAAAVDQLMRDVGAPVWTEKAFTALTDHVRTHLGDTVFDTVRAVRKILDAAHQVELALDTVTGPAYDESLADIRAQLTGLVHPGFVTATGTHRLADVHRYLQGISRRLEKLRENVRRDQDRMDDVHRVHAEYRELRATLPADEPQDALDDIRWMIEELRLSYFAQTIGTRYTVSDKRIFKALDAVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Y0</accession>
    <name>A0A7W7T3Y0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-C beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001586">
        <property type="entry name" value="Beta-lactam_class-C_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00336">
        <property type="entry name" value="BETA_LACTAMASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="33499" checksum="57CAF5504F802E9F" modified="2021-06-02" version="1">MSAVHGDEQLARRLAERLGARHPVVAAAEVSPRGTTIASVGASPDADFEIGSISKGVTGLLYADALGRGEIDDSTTLGDLLPLGDVPAAAVTLASITTHRSGLPSLPVPSLRKTFALWFQGTNPYGETLDELLDQTRGVGLGTPRPRYSNLGFELLGHALAAAADTTFRHLLRDRIATPLGLDVCYAPASPADLRPEAVIGTTRFGRRREPWTGEALAPAGGIRATIQDMARFAAALLDGSAPGTAALDPVADFTGRVVRIGAAWITLERDGRTVTWHNGGTGGFRTWLGLDRAAGTAVVLLSATAVSVDRHGFSLLADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C2</accession>
    <name>A0A7W7T4C2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="67"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="37405" checksum="5FD039AD8E76FB75" modified="2021-06-02" version="1">MDEVMGGPCVAAGIALHGSSGVEPKGVLAMRVSCVRIAIASCTLVAAALVAPALPASARAETVRWVAMGDAYTAGGIAAAGAEVVDGGLRDGCDRTAGSYPEVLRRMWADRYELVNVSCVGATIANVVSERQWPIGRESPFFGIADPDFPFPSVPAQMRALTPDTDLVTVGIGGNTLGFMEFVYACVVMGQWSDPETASPCAEHFTSGWDGVPTITDRLAVLAEQYGDMLMAIRAAAPQATVLAVGYPAIFPADPADCTVGQTPGGLLHFGTVTRPDLAWLRTAVVEPLNGVIAEQAAVHGVTFVDLYPAGIGHDACRPDGCDWVEGIRDETGEWALVRPNSAGHLAAAITIGAVLDAGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4L8</accession>
    <name>A0A7W7T4L8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="19855" checksum="48C43159E8725F71" modified="2021-06-02" version="1">MTVAWLWLRLHRWPTLVAITVATAAVTLLVGDERVPLPSFADVRRLGVPLGHLMPLLLASAVGLHSRAPTRLFLVTPRPARPQRAVLACVLVATASVAGVAGADDAVPRNILGLSGLALATAVAAGATRSWTLPLCHAMACVLFGSRIGPGGPRWWAFTIAPAGDRVAWAVALACGAAGTLLFVVRGPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R1</accession>
    <name>A0A7W7T4R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35219" checksum="02BFE76163E5ADDA" modified="2021-06-02" version="1">MGDNSARLLRLLALLQARQEWGGPDLAERLEVSARTVRRDVERLRESGYPVDSVGGVGGGYRLGIGGALPPLLLDDDEAVALAVGLRTTVALTGIAETSVRALAKLDRILPSRSRHRVDAVAAAVVATPASGAAVDTATLTAIASAVRDHHRLRFDYVDGGGRSAVREVEPYRLVHNGRRWYLFAWDVGRRDWRTFRADRVRPRVPAGPAFRPRDLPADDVAKYLVHGLTTARHRHRAVFLLHASAHDVAEVVPATVGLVEPVDGRTCTLSLGSDEPDPLLAWVASFGFDFEVREPPELVARLRSLTDRLKRAVERADRSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U1</accession>
    <name>A0A7W7T4U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="35463" checksum="B59CCE1C1441006E" modified="2021-06-02" version="1">MELEVRHLRALIAIDDARSLTLAARRLHVSQPALSGLLQRIERIVGDRLFVRSTTGCHATPLGLEVVAQARVVLDGMSAITERANDWASRRGGAAGPLRIGGYCGFLHVSVSRWLSEQPWCAGVRVQEDPDERVTLDRLALGALDLALVYLPPLPGAAVPPNVVDVLVHEAEPVFVAMAHDHPAARSGAVPLADLADHAWLDDQPGTTTWSTYLNRVCRDYGVVLDQPHTSTCLATVLELVRAGMGVVPAIATSLDRPANIVVRAIEDAPLWQELHLCYRPGTLVAEHIDEIHARVLDTYVARLGCNPAFDEWWRGRREPALSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T581</accession>
    <name>A0A7W7T581_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21420" checksum="AC385903288FB01A" modified="2021-06-02" version="1">MDSDTATLSPETLRAEMVAKVRKSGYAELSEVEQVLLDTPRHEFVPEADPVVAYDPWQAVITHRFEDGRSLSCASAPWLVAAMLDQLHVQPGNRILEIGAGTGYNACLLAQLTGRADLVTTIDIDPDVTAKASQALAATGYGDVHVITGDGGLGYADHAPYDHMIATVSPWDIPTQWWQQLAPGGRLVAPLRFPVKSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T594</accession>
    <name>A0A7W7T594_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12919" checksum="C734FC6887545113" modified="2021-06-02" version="1">MAAEIRYPGRRGDVVEALALFVALTPENVAHRPGDLDDAVHWLVDDTFWDLHDVADSIGFLLRDKREVAVIEAVLDPLLAVLGALGPVRPDVEYFCHERWPDVVAAAANAHRLLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C9</accession>
    <name>A0A7W7T5C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043993">
        <property type="entry name" value="T4SS_pilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18895">
        <property type="entry name" value="T4SS_pilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="14860" checksum="1F0DABB12271EEE8" modified="2021-06-02" version="1">MTSRAHTPTCAGLRQLANDGNTPPTSDKRSDRRSSIRRRVLLVTELVAVALLASGATAHADTVVLAIAGSVDEVLTNIRNWLMGILAGLATVFLTIGGVRRVFGGGDPGEQEKSKEAFKAAGIGYALAALAPLVVTVLKGIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5D5</accession>
    <name>A0A7W7T5D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative small metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5534" checksum="76D4F878EDA65F04" modified="2021-06-02" version="1">MKRNITCPCGEQITGQDEDDLVAKTQAHLKEKHPGHDYSRDEILFMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F0</accession>
    <name>A0A7W7T5F0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21644" checksum="42EF278493F6D1F5" modified="2021-06-02" version="1">MTIPWPDLPTAVADEIIGVLDKGVDQDWSRQAGDTAWTAWQLLDHITLAVTGYAGLLIARPDTPRYIALRTGNDRNASIPERFESIKIASTLLSHTLRVTGPEVRAYHSWGTSDAAGFSAMGAVEMLVHAHDLTRTLNLDWTPPDDLAAQVVERLFPNAPTDQPAGLALLWGCGRIALPGHAQFPRERWQWYGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K0</accession>
    <name>A0A7W7T5K0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="21575" checksum="1DFC3574CB26817A" modified="2021-06-02" version="1">MIRVVVVDDHPVVRDGLRGMLSAADDIEVVGEAADGAEAVAVVAAVRPDVVLMDLRMPGVDGVTAIGRLRGEPARVLVLTTYDTDSDVLPAIKAGATGYLLKDTPRDELFRAVRSAARGEAVLSPSVATRLVGQVRSPAAEPLSDREIEVLGLIARGCTNREAATRLFISEATVKTHLVHVYAKLGVKDRASAVAAAYERGLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N1</accession>
    <name>A0A7W7T5N1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkaline phosphatase D</fullName>
            <ecNumber evidence="4">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032093">
        <property type="entry name" value="PhoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16655">
        <property type="entry name" value="PhoD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030545631" evidence="1">
        <location>
            <begin position="30"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD_N" evidence="3">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD" evidence="2">
        <location>
            <begin position="145"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="501" mass="54697" checksum="9E7663F52E6AC114" modified="2021-06-02" version="1">MSPLSRRTLIAAGLVGAGATVLTATSAQAVAYPFTLGVASGEPAADGFVIWTRLAPNPLAANGLGGMSSASVAVEWQVAEDDRFTTITRTGTFTAVQAAAHSVHVELSGLQPGREYFYRFRAQGHISPVGRALTTPTTGSSLTMLFASCSHYEAGYFTAYRRMAEEHPHLILHLGDYIYEGAASSTQVRRHAPTVEIDDLADYRVRHAQYKTDPDLQAAHAIAPWAVVWDDHEVENNYANLVRNDSSPAGDFRARRAAAYKAYWEHMPLRSAQAPVAENMQLYRRVRWGNLATFHLLDTRQYRDDQACGDGTKVCPEADSPTRTLTGAAQEAWLLDGLRQKLGTWDFLGQQVFFAQKLASADGAKSMDSWDGYTANRDRLQRGWDAAGLRNTVVLTGDVHRSWASNLMLDYDAQDRIVGTELVTTSVTSGGDGNAADTGTSPLNPHVKFHKNLRGYVRTVTTPAQVSVDFRCVDKVTVRDYPVKTVQSYAIEAGNPGLQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R6</accession>
    <name>A0A7W7T5R6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="24201" checksum="FD37C717AC2C396A" modified="2021-06-02" version="1">MIAELGRVELKLLLRNRTAALTALAMPAAMGVFFAMSMGGDASSWVMVAAFQLAFTLGLGVYVSTATALVARRQDLYLKRLRTVAADRTVLAGIVGPTVVLGCVQAVVLLGVSFALGAPMPANPHFLLIALVLGAAMSAAAGVATSGVTATPELAQTTTLPFFAALLAGVIWAGAAPDDQRALLLPGSGLFEAARAAWAGPTDRTAMSVLVMAVWTAAAMVAAHRYFRWDRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C3</accession>
    <name>A0A7W7T6C3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine/adenosine deaminase-related metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="57"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="488" mass="51190" checksum="A25CBC2876A926A9" modified="2021-06-02" version="1">MAALLVTGGTLYPADAAASVIPDGAVLVEDGRITAVGPAAEVAAPADAQVVDATGTMILPGFVNAHWHDLFALRFPLRGALRPPHDRDDKPAFLALGGDLHQVTTTFDAFAGRIALLDPDEAAAIARYSLWTQLRSGVTTLGDVGSFNRPDALADAALFLGVRASVSTWASDAVCEAGATRFRRTRDADGVLAEIEALLQRAEADTTGLLRARPTAVYGVNMTDELGRGLADLAARHDVPFATHVGALRNEPEVSRTYFGASPVRRLADLGLLGPRTMAVHTAFVDEDERKLLVDNEVHISISPAKYGHAGESTLTETGLVPVLRRAGLDVSLSTDGGAVPVGGMAEAMKAAYQAFNELAADPTDLRPTDALAMATSVAARGLDWAGEIGSLEVGKRGDLVLVPADDWRYLLNPRPLEGFLALGGSTDVDTVIVDGKVLVRGGRAVLVDETELEADYLDAVGSFSVRVLGVPPEVVRAATGRRATKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N5</accession>
    <name>A0A7W7T6N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
            <ecNumber evidence="2">1.1.1.193</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.193" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="30"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="26012" checksum="F225D33C5D1333E2" modified="2021-06-02" version="1">MRMLWPPREPGPTDADLERLYAYPDRLDRPFVQVNFVSSLDGAVEVDGRSGALGNAADKKVFALGRDLADVVLVGAGTAAAEGYRGVKATEVRAERRARLGLSPVPPIAVVTDRCSVAPSSPLVTDTAVPPIVLTTAAAPAERRRALADAGADVVITGDDRVDLVAALDALASRGLSRVDCEGGPALFGALIEADLVDVLCVTYAPLLVGGTAGRIAHGRMPDAPRAMELTSALTYESALLLRYTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T700</accession>
    <name>A0A7W7T700_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain acyl-CoA synthetase</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="601" mass="64289" checksum="7B0DC632A02C5BDE" modified="2021-06-02" version="1">MREFSVPATATVAAEENLTDMVWANAERFGNAVSFRRRIDGTWVDVTSRDFAAQVLAVAKGLIASGLAVGDRVGLMSKTRYEWTLLDFAIWHAGGVVVPIYETSSAEQIEWILSDSATKALFVETAAHHATVDTVVADLPEVRSVWRIEGPGDGVAGAIDELTALGAAVSDDDARARRTEVGADDIATIVYTSGTTGRPKGCELTHRNLLAEVRSDINAFPRLMRAGNALLLFLPLAHILARAIALTAFSARVTLGHTPDVRNLVDDLQSFRPTFVVAVPRVFEKVYNGAKQKAHAGGKGKIFDAAEQTAVAFSKARDEGGPGLGLRIKHALFAKLVYGKLQAALGGRCVAAVSGGAPLGSRLAHFFRGVGVPVYEGYGLTETSAAACVNTESAFRVGTVGRPVAGTSLRIAEDGEVLIKGDIVFTGYWNNPAATAESLVDGWYRSGDLGALDDDGFLKITGRKKEIIVTAGGKNVSPAQLEDRLRAHPLISQCMVVGDARPYVGALITVDPEFFPAWRERTGKPATAGVADLLDDEDLRAEIQAAVDDANQAVSKAESIRRFRILPVDFTEAGGELTPSLKLRRSVVSDTYRRDIESLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T728</accession>
    <name>A0A7W7T728_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25092" checksum="4788C6187CED508A" modified="2021-06-02" version="1">MLRDTLIVYRVELAAAVRSRVAVAIGLVQPVLYLVLFGPLLTDALPGERAMTFFVPGLFVQLGLFATGYAGFSLIPDLRSGVLERLRVTPVSRAALLLGRVLRDATTLAVQGTALVLCGLAFGLRASWWGVPAGLALVVVAGVGLASLSYAAAVKLPGEYLFAPVVNSVAVPVMLLSGVLLPMSFAPGWLDAASRLNPLRYVVDGVRALFDGRLVVVDAAVGVAFAVACVAVALRTFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T737</accession>
    <name>A0A7W7T737_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="8" type="ORF">F4559_005128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="37294" checksum="653ABE311913C7F6" modified="2021-06-02" version="1">MTVVPEGRKLLRLEVRNSQTPIEKKPSWIKTKAKMGPEYRELKGLVKREGLHTVCEEAGCPNIYECWEDREATFLIGGEQCTRRCDFCQIDTGKPADLDRDEPRRVAESVQAMGLRYSTVTGVARDDLEDGGAWLYAETVRQIHALNPGTGVELLIPDFNAVPEQLAEVFASRPEVLAHNLETVPRIFKRIRPAFRYERSLEVITAAREAGLVTKSNLILGMGETPDEVTEALADLYDAGCEIITITQYLRPSPRHHPVERWVKPEEFVTHKETAEKIGFSGVMAGPLVRSSYRAGRLYAQAVTKRGDELPENLTHLLQAGEAAQEVTSLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A3</accession>
    <name>A0A7W7T7A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NitT/TauT family transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030810210" evidence="1">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="37839" checksum="3128696F3B5FC13E" modified="2021-06-02" version="1">MSSRRTILTKSFAILTAFVALAACSRADGGDTAASNAPAQDKGPAAEIRLGYFPNVTHAAALIGVENGLYAKELGNTKLTTQTFNAGPEAVNALLGSSLDATFIGSGPAINAFAKSNGEAVRLIAGATSGGAQLVVKPEINSAADLKGKVITTPQLGNTQDVALKKWLSDQKLTVGSGADQVNITNTENAQSLDLFKKGDVQGAWAPEPWSSRLVLDAGAKVLVDEKTLWDGGKFPTTVLLVRTEFLRDHPQTVEALLKGHLAATEFATSNKPEAKKIVNEALKKLTGKQLGEPVLDRAFDNIELTLDPQAKSFPQLAKDAVTAGVSKEAAKVEGLVDFTLLNKVLTAAGKPTVDAAGLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7B0</accession>
    <name>A0A7W7T7B0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17869" checksum="17BFA94052025123" modified="2021-06-02" version="1">MVFRRIFGSGAPKGFAGVLERDENVLASAACGDEWLVATTLGLWLPGPRRVGWHLISKATWGSGALTVVEAVEDGTAGAAVLLRDLPAVRYPLATPGRVPEVVYARVTGAIRDRERNEELRAWFLRRKVPGRDGVVLHVRPDPDADVERVRRVAASVAEKLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7B7</accession>
    <name>A0A7W7T7B7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS superfamily sulfate permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="6">
        <location>
            <begin position="14"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="481" mass="50075" checksum="89C9B496ED1BB31A" modified="2021-06-02" version="1">MTRQEELPARTGTFVPDIGASLVVFLVALPLCVGVAVASGVPAELGIVTGVVGGLVAGVLPGSSLQVSGPAAGLTVLVADAVASHGLAAMGLIVLGAGLLQIAMGLLRLGRWFRAISPAVVQGMLAGIGLVLILSQLYPLAGQEQPRTTGEKFAGLFELLRDAVVNPAAVAVAVLTLVVTALWQRAPEKVRMVPGMLVAVVVASAVGAFLPVPRIEVGPLSDVIMLVDVSLLDAGVFGAMLTFALVASAESLFSAAAVDRMHNGPRTRYNRELVAQGVGNTVCGVLGALPMTAVIVRSATNVRAGARTKLSRVLHGVWLLVFVVVLPEVLAFVPIAVLAALLVQAGWKLLELPRVVKLVRTDRAESAVLLLTAGLIVVTDLLTGTLVGLLAAVVKTAWDVSRLSVVVDEDGPDHEHVTLRGNATFLKLPRLLDALEGLPVTKHVRVDLRGLRHLDDACRQAIEGWAEAHRAAGRSVNLIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G8</accession>
    <name>A0A7W7T7G8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="31498" checksum="1FCE8BAD77114EDA" modified="2021-06-02" version="1">MYAIEAEGLARVFGQVEAVRSVDLAVRPGEVVGFLGPNGAGKTTTLRMLATVLAPTGGRARVAGHDLRAEPDRVRRRIGYVAQSGGTRPLSTPREELVLQGLLHRLPDAARRADVLLDDFGLGDARDRPVATLSGGRRRRLDVALGLVHRPEVLFLDEPSTGLDPGSRAALWDHVRALDATVFVSTHYLDEADALCSRVSIMDQGRIVAEDSPGALKAAVGHDTVVIGLAGHDVDVVDAVTDLGEASLDGDTLTVTCRDGARLLPDLVRRLGDAGAEIRSVVVRGATLDDVFEALTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P1</accession>
    <name>A0A7W7T7P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008497">
        <property type="entry name" value="DUF779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05610">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009151">
        <property type="entry name" value="DUF779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13290" checksum="4AAB95BC69A76A0D" modified="2021-06-02" version="1">MPRVDVTPEAAEVIRGLRAEHGDVMFHQSGGCCDGSAPMCFPVGEFRTGASDVHLGDLVVDGRPVPVWMSAAQFEYWRHTHLTIDVVPGRGAGFSLEAPSGVRFLTRSRLLTDEELTLPGDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T878</accession>
    <name>A0A7W7T878_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellum-specific ATP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="154"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="46193" checksum="F24302F5403365B0" modified="2021-06-02" version="1">MTTLTFPVPELAAYGKPRVVGRVTGVVGLAVSVSGITARVGDLVHIGPQDAPLPAEVVSLSADRVVCLPLGPLDGIGIGQPVVNTGHPLRVVVGEGLRGRVLDGLGEPMDGGPAIVGRPVTVEMPPPSALERGLIREPLQLGVRALDTAVPCGRGQRVGIFAGSGVGKSSLLSMITRGTSAQITVVALIGERGREVREFLEHDLGPEGLARSVVVVATSDQPPLVRLRAGFVATRIAEWYRDQGMDVLLLMDSLTRIATAQREVGLSAGEPPATRGYPPSVFALMPRLLERAGPASKGSITGLYTVLVEGDDHNEPIADTARSILDGHIVLTRALATAAHFPSVDVLESVSRVAGAVTTPEQRADLSMLRRLLAAHRDVRELVEIGAYAAGSNPDADRALALWPRLMEFLRQDMDDRVPSAQSWAALRELLHGTETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8H6</accession>
    <name>A0A7W7T8H6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031289964" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="45"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15359" checksum="E801364C3EC58B27" modified="2021-06-02" version="1">MRRTLGTALATGFAAVVLTAGTAPAWAAGGTPCSIQEGACLKLSTNQAWLVYHGNASYGPVPVTHGRPGYETPTGTFPVLRKVRNDWSIPYNAPMPFSVYFTSDGIAFHEGSLTDLSHGCVHLSHAAAETFFDNLLPGEQVQVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S6</accession>
    <name>A0A7W7T8S6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase (NADPH)</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="563" mass="59361" checksum="266415714ADE3849" modified="2021-06-02" version="1">MTASTRIDLGTPLTETPDSCGAFPRLTDEQIRVLGEEGERRPVRAGEVLYAQGGWPSEFFVILSGKVAVTEGTGDDAKVVRVHGPRRFLGELGLLEGLPAFVGAVAADPGEVLAIPVSAVRHLVLGDPVLGDLILRAYLVRRTLLIGSGNGLRIVGSCYSPDTRRLLEFVARNRLPYRLVDVDKDQQTEALLERFGVAVADTPVVVVNGTEVLRNPSTAELAGRIGLLPPEPETGVRDVLVVGAGPSGLAAMVYGASDGLRLSAFDAMAPGGQAGTTSRIENYLGFPPGISGAELAERSVIQAAKFGARVAVPAQARTLEARGGRYAVGFDDGIEIVSHTVVIASGARYRRLVVPGIETFEATGVYYAATVHEARRCLASPVAVVGGGNSAGQAAVFLAEGSPVVHLLVRGGDLAANMSRYLVDQVEQHPRISVLGHTEVRELVGGDGLESVVVENNRTGERRVLDARALFVFIGASPHTAWLSGTVALDEDGFVLTGADAEGFRDADVWRGVHRAPLVLETNRPGVFAVGDVRHGSVKRVASAIGEGAMAVRFVHEHLSQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8U5</accession>
    <name>A0A7W7T8U5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferredoxin--NADP reductase</fullName>
            <shortName evidence="2">FNR</shortName>
            <shortName evidence="2">Fd-NADP(+) reductase</shortName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + NADP(+) + 2 reduced [2Fe-2S]-[ferredoxin] = NADPH + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:20125"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01685">
        <property type="entry name" value="FENR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022890">
        <property type="entry name" value="Fd--NADP_Rdtase_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="33901" checksum="964D305D176AC245" modified="2021-06-02" version="1">MDLEVDLLVVGAGPTGLFAAYYAGFRDLSVALVDSLPEAGGQITAMYPEKMIYDVAGFPAVRGRDLVAALVRQAAQWSPTYLLGRQARELSTVDDQLVVGLADGATVRAGAVLITAGIGEFRPRPLPVGDGWLGRGVVHFVPKLSVYAGQDVVVVGGGDSAFDWALALHPIAASVTLVHRRATFRAHPPTVRQVRELGVEIITDAEVLELRGDDVVREVELGLKGGDRKALPAQAVVAALGFTADLGPIESWGLELDHRAVVVDTTMRTALDRVYAAGDVATYPGKVKLIATGFGEAATAVNNIAVLLDPDAHLFPGHSSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X7</accession>
    <name>A0A7W7T8X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyrroloquinoline quinone biosynthesis protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022479">
        <property type="entry name" value="PqqD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03859">
        <property type="entry name" value="PQQ_PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9357" checksum="F4906E5B72D7A26E" modified="2021-06-02" version="1">MTGPDSVPRLRKGVKVAFDDVRSGHVVLFPEGVLVLNDTAAAVIALCDGVASVRTIADRLAVDYAGVEPADVAELVDRLADRRVVDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9A9</accession>
    <name>A0A7W7T9A9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lexA</name>
        <name evidence="17" type="ORF">F4559_005024</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="16">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="15">
        <location>
            <begin position="113"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4967665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="25058" checksum="70447602312811E8" modified="2021-06-02" version="1">MARKTEDEPRTDAPSGPEPADVAGNAGLTLRQRKVLDVIRDWLDRFGYPPSVREIGEAVGLTSTSSVAHQLRALERKGFLRRDPNRPRAVGVLPTEIVTGLDPASKPTPAYVPMLGRIAAGGPILAEEAVEDVFPLPRDLVGEGELFLLKVVGDSMVDAAITDGDWVVVRRQPTADNGDVVAAMIDNEATVKTFKRKDDHVWLMPHNSAYEPILGDEASILGKVVAVLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C8</accession>
    <name>A0A7W7T9C8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20785" checksum="6F7464396436A4B3" modified="2021-06-02" version="1">MTKGEPSVYDGDISSVLITEQEIGDKVAELARKVAADYPAEDGNDLVLITVLKGAVMFTTDLARALPVPVQLEFMAVSSYGSATSSSGVVRILKDLDRDIADRDVIIVEDIIDSGLTLSWLLKNLASRRPRSLEVCTLLRKPDAVKVDVPVKYVGFEIPNEFVVGYGLDYAERYRDLPYIGKLDPKVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q7</accession>
    <name>A0A7W7T9Q7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="120"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="34911" checksum="A1AD38A28EBC97E6" modified="2021-06-02" version="1">MKKSAAAYAYAPGEWKTLGLEWCRSLEADNKSPNTVRIYLHALRLLGEWAYDQADDEFEPTTITTSALRDYMVDLLGRTSPGNAHNNFRCLRTFFGWLVNEEEIERSPMDRMKAPQLEEKPIPIVTLDMMSALLDACKGNDFENRRDTAILRVLFDCGARKGEVTALTLDDIDLELGVIYVRGKGRRDRVIPLSPKTIQSLSRYIRSRAKQRQAALPGLWLGLTGQGILTGAGIKAMLIRRSAQAGVGHIHPHMFRHQLAHHWQLAGGNETDLMRIMGWKSREMLERYGASAAIERAHATARSLKLGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T7</accession>
    <name>A0A7W7T9T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="PTHR12704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23604" checksum="5E74C39C82A2BE71" modified="2021-06-02" version="1">MGNLAEEIALLAYDDSGALRLGRPVFEYGLAGGVLLDLALAGRIDVVDNRVTVLDPTPTDHPVLDHALAAIAADKDRKPKDWVTRLSKGLPDRVLSSLVDAGVLRREQDKVLLLFPRTRYPAPDGGEPAEETEARQRLARAITSEDPVDPRTAALASLVAALRFERKVFKDLPHAQVKARLKTITEGDWAGKAVRRAVDEIHAVLTATVVIPAITTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V8</accession>
    <name>A0A7W7T9V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30811" checksum="0915E7D4EACC7634" modified="2021-06-02" version="1">MPIGYPDTVFRYEPLSDRPVGRGGCGNIWKARDILLDRTVALKTVNEQLLWHDDERARRTFLKEATAGARLAQSSRHVVPVTDLGIADGIPYFVMPWIDNGTDPPDLGGQIGRMSVGRARAVLAQITEAVAVAHRNGIVHSDIAPWNIVHTKAENLYQLTDFGLLKIVENQLLSVGSGSLLRGGRQDFQPPEVRADIAAVDYSSDVYALAVTFRVLIEGDSCLRTKGGSPFPTPGVIRVRHEQRDAPDRVRQLLVRFVDEHERTDTVDDFTELLRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA21</accession>
    <name>A0A7W7TA21_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ComB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="23460" checksum="FBDFEF3D6CDED08E" modified="2021-06-02" version="1">MFGQEGSLVRLEWGGEGVAALGGLCAVLVVVDVLSFSTSVDIAVGRGASVRPVRWADREQAASYPSWSLRPSSLVDLPRGTELDLASPNGATLSALAAGTGSHVLVGCLRNAGAVARAARTLAAGGPIGVIAAGERWGVDVNSPGTAYLGPLRPAVEDQLGAGAVVAGLLGYGSASVEAALAADLYSRSSVVDVLHGCVSGRELITAGHAGDVELAAAVDVSAAVPRLVDGLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF5</accession>
    <name>A0A7W7TAF5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="17488" checksum="7E502BFCB09FD74A" modified="2021-06-02" version="1">MSDLNATAAALLGLLHDGPKTGGQLVAEAGERFGAFFSVTRSQVYRELPALADAGLLRLGKQGPRSSQQYVLTAAGKKAFKNWLLTEPGPDHLRSPLILRLVHAGSLTAKQRQGLVDAARARYGADQEAAKTAVKTAEDAYSKAVAEFGLAHAKAVLKLLDAIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT33</accession>
    <name>A0A7W7WT33_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding Lrp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14588" checksum="0ABD8D77413314F6" modified="2021-06-02" version="1">MANARSSYADIGKEVGLSAPAVKRRVDRLLDTGVLRGFTAVVDPEQLGWGTEAFVEVHCRGNVTPQDIRQRLEPLAEVMAAYTVSGAADAIVHLRAANIHHLETALERLRAVEIIDRTVSTVVLSRLLDRPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTY6</accession>
    <name>A0A7W7WTY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030646756" evidence="2">
        <location>
            <begin position="24"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="388"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="514" mass="56013" checksum="574FA5525D0EBD01" modified="2021-06-02" version="1">MRKLVVAVSALALVASVPAVADAAPEAVKAAKQFDDQKLAWGPCTDIPNAPPLLECATFGAPRDWNRPNDGNKITIAISRLKPKGPTKSSVLTNPGGPGAPGREFALAFASRTKLVDNAEVIGIDVRGTGASTNVTCGDFDSSNLVDPRDRSPRNVKLFYDAAEFQATTCQTLSGDFGKYVNTEQTVKDLDLLRRLLKRDKISWVGYSGGTWMGAYYATYFPERVDKFVLDSNAEFTTTFQDVFDEFGRGFERRFRTDFLPWVAKYDNVFHLGTTAEAVRQQYEKARAALTANPIPLPDGSHLKAVHLDSLLVQVQYSKNYFQIGAEFLAAVASGAVPATTANAALGLTQYRDASSATFYAIACNDTRYLGGRKYLAEKAERLGAQYPLIGYYQIDAACAFWERPALQLKKPTGKGVPPILMVQSERDPATPVEGARRSHEKFAGSRLLTVTDEGDHGIYAFGNKCVDDIVEAFLVDAKVPDKDLTCAGVPLPDPTAPQAKADDTVRRPIFFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ2</accession>
    <name>A0A7W7WTZ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen operon protein</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="162"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="702" mass="76621" checksum="B0EC7E74D470A194" modified="2021-06-02" version="1">MAADTLPLAGRPFPLGAHPEAGGVRFAVCAPPAEAVEVCLLDDDGGEERVELIERTFGVWHGLIPGVTPGRRYGYRVHGPYDPSRGLRSNPAKVLLDPYARRVSGSLTSLDDALGYVDDPMHGPPSAVDSLGSVPLAVVTAPGGPDTGVKPDVPYEEVVVYELHVRGFTRLHPDVPAHQRGTYLGLAHPAVVEHLVRLGVTTVELLPVHAFQTEPALIKNGRENYWGYSPLSYFAPHPAYASEPGREVEEFRTMVAALHAVGIEVLLDVVFNHTCEGGPDGPTLSLRGFDAPGYYMHVVGGGTFDITGCGNTVESGTPSVIRLVTDSLRYWAGELGVDGFRFDLASTLGRPGGGGFDRDSALLTAITTDPLLSRCKLIAEPWDATGEGYRVGDFGVQWAEWNGRYRDTVRDFWRGHTGVRDLAYRLSGSSDLYADDLRRPWQSVNFVTAHDGFTLRDLVSYDHKHNEANGEDNRDGTDDNRSWNCGVEGETTDPDVLELRARQARNLFATLLLSTGTPMITAGDEQWRTQSGNNNAYCLDDETSWVSWKPDPTAESMLAFARRVIALRAESPALRQPEFFDGRTTPSGKPDLVWFRHDGEEMAETDWFDEHRRFLGMWIDGSTALSHDREGGVVSDDSWLLLLNASPDGIPTTLPPAEYGTTYEPVLDTTTHDGTPPSPTPLPSGATFTLPSRALLLLRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF8</accession>
    <name>A0A7W7WUF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13131" checksum="7174FA4D3864D3EF" modified="2021-06-02" version="1">MRVVWATCGLAVAASALTGVLVGFYLDDDPEGDADVPGSTWITERPSATGTSARTITVTTAVTTEAISAPRTTTSQPGTTTEPPPPQDPTTTVTTTVPATTTTTKVRRTEWPCGPLNPFPPPQCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ8</accession>
    <name>A0A7W7WUJ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26518" checksum="93102D256422FB7E" modified="2021-06-02" version="1">MRADVNGVDTWYEVRGEGEPVVLLHGGFSDSRDFEDNLAGLADRFRVYLVDRRAHGRTPDVPGPVTSDDLADDVAAFLSDVVGGPAHVVGYSAGGVVALAVALRHPGLVRRLVLISTAFAADGWLFLPDPAGELPAELADRYAEVSPDGRDHLPVVVAKFGEAARGKGCTAEALHDVDVPALVLAADDDLIRLDHTVAMYQALPQGQLAVVPGSSHLLLFERPGLCRGLVADFLTTDPHRLMPIARAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ0</accession>
    <name>A0A7W7WUQ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (TIGR00106 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00106">
        <property type="entry name" value="TIGR00106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10483" checksum="9E234F94830F136B" modified="2021-06-02" version="1">MLVAFSVSPVGGESDSVAAAVAEAVRVVRDSGLPNETNAMFTLVEGEWDEVMDVVRRATEAVAAVSTRVGLVLKADIRPGYTGQLTAKVERVERHLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV6</accession>
    <name>A0A7W7WUV6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15936" checksum="6780B9CFB180AA6A" modified="2021-06-02" version="1">MSSPSDKQSRPSRDDQADPAPRPSRRVFTPDYKLAVVTEYENAPAGEKGAILRREGLYSSHIIEWTRARDAGRLTGQPAEPGAQTKPARKSAEQVELERLRRQNEKLASDLAKTRMALDIMGKAHALLEELSGSAEDDTPPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW7</accession>
    <name>A0A7W7WUW7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15279" checksum="20EB9FCEE5DA6BCE" modified="2021-06-02" version="1">MESTDSRTKPFPVIALTVTHRVSGAACLAVLAYTAVALDIRAGWVRFAFAVVVIGGAAVLNLIAPRRLADPRPGDDPDQAFISGTTRLAMVSVFAAGGPIVRGSMEAGFTVLLWVGVGLVLVSIAMAYLVGALRKPPVREWFEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV11</accession>
    <name>A0A7W7WV11_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein F4559_001995</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32406" checksum="6BF2A4465A03360B" modified="2021-06-02" version="1">MSAPAGEKSGIEVAVVTGLSGAGRSTAAKCLEDLGWFVVDNLPPELIATMVELGAQARGAITRVAVVMDVRSRAFTDDLAAVIKDLDARGYKPKVLFLEATDDVLIRRFESVRRGHPLQHDGRLADGIAAERVLLTPLREEADLVLDTSALSVHQLRAKIEDTFGSESAMRTRVTVLSFGYKYGLPMDSDLVMDVRFLPNPFWIPELREQTGLDGDVRNYVLTQEGAEEFLDRYHELLRLIGAGYRREGKRYLTLAVGCTGGKHRSVAISEELAARLASEDGMAVKVVHRDLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV22</accession>
    <name>A0A7W7WV22_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (DUF885 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="539" mass="59182" checksum="E6A18B3CEC849519" modified="2021-06-02" version="1">MTETTTPTRLVDEFLAWHFDRNPGTAALLGSLAHDHTLGDFDAASFAAHEREAGRWLDRFAALETADHAESIDRDLVLAMLRGVRARATWPAWRRDPALYLSAVLYPLHAAFLNRLRPEPELVASVITRLAQVPGVFAAAKDNLDPELASPLIVRRAAAQARTGRSFVTRTLVAEVADPDLRARLAAAAEPAAEAFDDLAAFLDAFAGTARGDWRMGEALYSTLLREQEVLGYGAAELHERGKAAYAELEADIRAVAGQDDWHAAMVALQDDHPPTPEAMRAEYEAETLRARAFLVEHGLVTLAEGEECRVVPSPAFQRPVLGVASYMAPPPLTSARVGHFFVPFPPDDFTAEQTTQRLRTNARSQLATIAVHEAYPGHHWHLSWLAAQDRPVRKVFRTPYFAEGWALYSERLLREHGYFATGPGDAAAARGRELAHVEAWLFRAARMVVDTALHCGDMTVEQAREFMTTKSSLTPGTAVAEIDRYCAWPTQAPSYLTGALEILSIREEFTGSPREFHDTIAGSGALPLGLARRAALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV32</accession>
    <name>A0A7W7WV32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="23"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="472" mass="49890" checksum="138EF5643D56254C" modified="2021-06-02" version="1">MDEQTATEPDADGYTKSLTKRQVQMIAIGGAIGVGLFLGAGGRLAQAGPSLVFSYALCGLAAFFVMRALGELVLHRPTAGSFVEYAREFIGPWAGFASGWMYWVNWAMTGIAEITAVAIYVHRWLPDLPQWITALIALAVLVAVNLLSVKLFGELEFWFSVVKVTAIVVFLVTGIALVVGSADVGGTPASPANLVDHGGLFPAGVGVALLTLQAVVFAYSAIELVGIAAGETADPRRVLPKAINGVVYRIGIFYVGSVLLLAMLLPWTMFSAAESPFVTVFSHLGVPAVGDVMNAVVLTAALSSCNSGLYSTGRILRSLARHGEAPAFTGRMNSHHVPYGGILFTSVAYLAGVVLNYLVPKEAFDIAIAIASLGVIATWATLLVSQLRLRKAALRGEIRRPDYRMPGAPYTGYATLAFLGTVVVLMAFAGTAERIAFWSIPVLALVLFAGWRALQSRRSAADPAADRVGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV73</accession>
    <name>A0A7W7WV73_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="37" mass="3744" checksum="C444B9F3EEB73661" modified="2021-06-02" version="1">MGAPGGRRIDEDWLAVVVGLALFALALVGAIKPGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV78</accession>
    <name>A0A7W7WV78_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15194" checksum="1CB1CE93D52593D4" modified="2021-06-02" version="1">MAATIWQYVVPYEGDFDAALDRLKAEVFASGRFHWCGGPRPATIAEVWADDIEHECGTHSILDMFRVQPPNEKPKSFTVSVVTPEEVEAHLGHSRPTVEFAALLDDLATTRWQGRCAVLYDEAGTPTSLRFWGASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB0</accession>
    <name>A0A7W7WVB0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrA</name>
        <name evidence="16" type="ORF">F4559_001712</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="619"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="651"/>
            <end position="658"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4964353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="951" mass="104035" checksum="5FAD2656A125C1F0" modified="2021-06-02" version="1">MADRLVVRGAREHNLRGVDLDLPRDSLIVFTGLSGSGKSSLAFDTIFAEGQRRYVESLSAYARQFLGQMDKPDVDFIEGLSPAVSIDQKSTSRNPRSTVGTITEVYDYLRLLYARAGKPHCPTCGEAISRQTPQQIVDQVLAMASGTKFQVLAPVVRGRKGEYVDLFSSLQSQGYSRAKVDGTVYALADVPKLKKQEKHHVAVVIDRLTVKASAKQRLTDSVETALRLADGLVELEFVDVPEDDPGRVRGFSENLACPNGHALAIEDLEPRSFSFNSPYGACPTCTGIGVRKEVDPELVVPDDELSLADGAIAPWASGQTSEYFTRLLESLSTTIGFRMDAPWRTLPAKVQKAVLHGVPEQVNVRYKNRYGRERSYYANYEGVIPFLERRQEQTESEYMREKYEGYMREVPCPVCQGTRLKPEILAVTLHHGDKGDRSIAEVCAMSVAECSEFLDGLKLGKREAMIAGAVLKEIQARLHFLLDVGLNYLSLDRASGTLSGGEAQRIRLATQIGSGLVGVLYVLDEPSIGLHQRDNHRLIETLTRLRDLGNTLIVVEHDEDTIRTSDWVVDIGPGAGEHGGQVVHSGTYQQLLKSKTSITGQYLSGRKSIAMPEVRRPVDKKRQLTVVGAREHNLRGIDVSFPLGCLVSVTGVSGSGKSTLVNDILATVLANKLNGARQVPGRHTRIKGLEHVDKLVQVDQSPIGRTPRSNAATYTGVFDHIRKLFAATTEAKVRGYQPGRFSFNVKGGRCEACAGDGTIKIEMNFLPDVYVPCEVCKGARYNRETLEVHYKGKTISEVLDMPIEEAAGFFEPINAIHRHLRTLVDVGLGYVRLGQPAPTLSGGEAQRVKLASELQKRSTGKTVYILDEPTTGLHFEDIRKLLGVINGLVDKGNTVIVIEHNLDVIKTSDWLVDMGPEGGSGGGMVVAEGTPEDVAGVGSSHTGQFLREVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH7</accession>
    <name>A0A7W7WVH7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22815" checksum="3D00CBDD8DA827EB" modified="2021-06-02" version="1">MVENRHGVALVERVLDVVREKPGRSMFDYTDVPWVEGGPRPLTDDLVFPSGRPLSPSLRAWMSYDFGLFERYDWFDEDGDLAPRPLDELASDEYGELWGQFYQPIAEKFPECFLLPGGSDSRRVLAVGEPDSAGEYPVLALDIDDMPFAGLMFPGFDVYAAHTAGLVTDDFQGYTDLADDPVYGPRMREHARIRFDGGLYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ1</accession>
    <name>A0A7W7WVJ1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">F4559_001952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="20176" checksum="DFB103F241C00437" modified="2021-06-02" version="1">MATTNDLKNGLVLNLDGQLWTVTAFQHVKPGKGGAFVRTTLKHVLSGKVVDKTFNAGTKVETATVDKRGMTYLYKDGSDFVFMDGDTYEQLNVPAETVADAANYMLENQEAVVAVHEGVALYVELPTSVELVIQHTDPGLQGDRSTGGTKPATLETGAEIQVPLFVTTGEKIKVDTRDGRYLGRVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN4</accession>
    <name>A0A7W7WVN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="30228" checksum="C6B6EB732E8AF31D" modified="2021-06-02" version="1">MTRAVVLSGYGGPEVLVEADVPTPSPGPGQVLIAVRAIGLNPFDVKVRSGAFRDVMPLDLPAVLGLEAAGVVVESTVDDFAVGDEVFGLVDGGAYAERALATAVARKPVGLDWSLAAALPVAVEVTGRVLRALDVAQGETVLVNGAAGAVGTIAVQMSVARGARVVGTAGDANQDHLRSLGATPVRYGAGLVDRVREISPGGVDAVFDVAGRGALPDSIALAGGPDRVVTIADPEAERHGVRFSGGAEPDPGEFAAVAEAVAAGRFTVTIDRTFPLSEAAAAHAWLEAGHTRGKSILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV2</accession>
    <name>A0A7W7WVV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10091" checksum="99337C4D5CC0604F" modified="2021-06-02" version="1">MNLLAVLVLAAGTYAFRLAGPLLRDRITLSPRLRDLLATAATVLLFALVATSTLTKGDWALPAGVLVGGVAAWRRAPFVLVIVLAAVTTAGLRLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW22</accession>
    <name>A0A7W7WW22_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038752">
        <property type="entry name" value="IQCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041356">
        <property type="entry name" value="PGM1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14465">
        <property type="entry name" value="PTHR14465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18105">
        <property type="entry name" value="PGM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="335"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="495" mass="53255" checksum="EB8A0CDCAD64B9FA" modified="2021-06-02" version="1">MILDPPKTSDFPRLQQRLGALFDDGSNDPLTVVVVPSLTLHHDELRKIPGAVHFEQRLLFQFQLLRDPRVRLVYATSRAVDAALVEYALGLVPGLDETARQRLTLLDCGDDSPVPLTAKLLAHPGALAAVRAAIPDPDRAYLVVFTSTAVERELALRLDIPLYACDPELAPLGTKSRGRRLLREAGLPVLPGFEDLSSERELVDALARLKQENPEIRKAVVKLNDSFAGAGNATFSYDGAPDGDLNSWIAARLATRISAPGDSWEGFRDKFAAMGGVVECFLDAQVPHSPSAQLELTPAGGVRVLSTHDQVLGGPAGQTFVGCAFPASDLYRTAVHDLALRAGRELARHGVVGQLSVDFVVDEAEPDRVYALEINLRMGGATAPFMFTHGLLAGHYDAESGHYLAADGRPRCYVTSDRVHDAAFRTLTCADLVRVAREHGLAFDPAAGTGTFYYNLGALPDHGKLGVVAVGGSREDAQRRYDDLVAALRSTASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW51</accession>
    <name>A0A7W7WW51_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34984" checksum="A0F49A3CF61DA823" modified="2021-06-02" version="1">MGNAEADPDPSLPMSRRTLLRGTGLALGGTALANGTADAHPPGVPVPGPGSPVRPIPVPGQVPATRGLFEVPGARLWYWDTGGPGQPVVLLHALSGSGESWPYQQPYLARAGYRVIGYSRRGYAHSPVRDPDDPRTGIEDLHDLVEFLGVGKFHVVGVAGGGWYAMDYALNHPDRLHSLVIGACVLQVQERDYQDMVGRLRSPEVDALPVHFRELGPSYRATDPDGVAGWLDIHHRAGPDGIVQPRATSLTWAVIERLTVPTLLLWGDGDPFTAPPVQRLLAGHFRRVRTVVANECGHNVHWERSDVVNPVLRNFFRDNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB8</accession>
    <name>A0A7W7WWB8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Catalase-peroxidase</fullName>
            <shortName evidence="8">CP</shortName>
            <ecNumber evidence="8 9">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">katG</name>
        <name evidence="12" type="ORF">F4559_003588</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>AH2 + H2O2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="8 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="PTHR30555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="SSF48113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 9" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEROXIDASE_4" evidence="11">
        <location>
            <begin position="160"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)" evidence="8">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4966229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="744" mass="81169" checksum="C6C7198C9B2FB5FC" modified="2021-06-02" version="1">MSDSHNAVVGDMNVEGAGGCPVRTGRIGHPVEGGGNRDWWPNQLNLGILRKHSAASDPHAGDFDYAAEFLTVDLDELAADVDAVLTTSQDWWPADFGHYGPLMIRMAWHSAGTYRVQDGRGGAGAGMQRFAPLNSWPDNGNLDKARRLLWPVKKKWGRKISWADLMIFTGNRALETMGLKTFGFAGGRADVWEPDQDVYWGPERTWLGDERYSGDRDLENPLAAVQMGLIYVNPEGPNGNPDPLAAARDIRDTFGRMAMNDEETVALIAGGHTFGKAHGAAPADEHVSAEPEGAPLEEQGLGWRNSFGSGKGRDAITSGLEVTWTATPTKWDNTFFENLFDYEWELTKSPAGAHQWQPKGGAAANTVPDPESGELKRPPTMLTTDLSLRFDPVYERISRRFRDDLDAFADAFARAWFKLTHRDMGPIQRYLGAQVPQEELIWQDRLPALDHETVDAADVAALKREILESGLSVSRLVATAWASASTFRGSDKRGGANGARIRLEPQRNWEVNEPDELAGVLTTLEGVRDRFNAAQTGGKKVSLADLIVLGGNAAVERAAELAGHTVEVPFTPGRTDATAEQTDAESFAPLEPTADGFRNYVAKGHRLPAEYLLVDRANLLTLTAPETTVLVGGLRVLGANHRQSAQGVLTDRPGTLTNDFFVNLLDMGVEWKPTSAESEAFEARDRSTGEVRWTGSRADLVFGSNSELRAVAEVYASDDAGAKFVADFVAAWAKVTDLDRYDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF4</accession>
    <name>A0A7W7WWF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6964" checksum="BBE72CA3D7DA5B5C" modified="2021-06-02" version="1">MRATDVEVAIRAAEAGVVRARCGARLKRFAQAGDDFATEVDIAAADARTPAEPLDLVSRGRRPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL8</accession>
    <name>A0A7W7WWL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="40919" checksum="9430E3F8865512F8" modified="2021-06-02" version="1">MSQLLHPLRHGDFRRLVGGRSLNHFANAMAPIVLSFAVLDLTGSVVDLGLVVGARSVANVVVLLFGGVLADRLPRRLILQGTSAAAAVVQAVIAAAVLLGFASIAVLVVLSVANGVVAAASLPAVAALIPQTVPPDEIRPANAVARVGVNLGLVTGASTAGLLVGFSGPGWGIAVNALLFAGSALCYLGITVGGTARPPEQRTHPLTDLLEGWAEFVSRTWVWVVVVQFLVVNAAVAGGLHVLGPTIADRTFGRTTWGLLLAAQTAGALLGALIAARTRVRHPLRLGVAVTAVEAVPLLALAGTSNPVPLVCAMVANGIALEQFAVAWDVSLQENVPADKLARVYSCDAMGSFIAIPLGEMAAGPISTRLGTAPTLVAGAALVVAATAATLLSKDVRGLRAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP3</accession>
    <name>A0A7W7WWP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylation response protein AidB-like acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="237"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="42242" checksum="41192CF0E405857C" modified="2021-06-02" version="1">MTQDTRTVLEAVRDLVPVLRKNGQRADEDRWIPEENIALLEAAGVWSMSVPKRFGGLELPLAEQVEVITEISRGCGTSGWVTGVYVGSTWAATLYPDRTQAEVFANGSVRISIGFAPTGKVTKTDGGWILNGQWRFNSGSKGAHYNMAAAVYETEDGGHGEVLCLVPIEKFSFVDDWHVFGGSGTGSVTTVAKDVFVPDHYAVDFEPLMVSDTPDRSNGGADGRNYALLALVLAGGAATSLGIAKAAYELFVERLPGRPITYTPWEDQTQHPVTQITVAKARNNIDAGEALSRGYLKLLQDRADAGEQPTDEEKAIIRGQTGYIHQLAKEAVELLYTLSGGSVVQRSVPFQRFYRDILAFTQHALVNANVNLEIQGRVLLGLDPATPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ3</accession>
    <name>A0A7W7WWZ3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="2">
        <location>
            <begin position="178"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="41998" checksum="CE3D9AEE17211654" modified="2021-06-02" version="1">MTTPTPPAAPPAPAPTTTPTTPAGAPKRLGNGELRAMVAKVLADNAGTDLTPRTIAHTLNRSSGAVGNACKVLADRGEAEVASTSPLAYRATATTASAAAPRITPAPPRTPRPKPPKPTTSAPTPARSGAGGSAARSAGVVTGPVKRPNGMDYHPRLLSGMPDVTALRRLRDAGVAALLYGPPGTGKTSVVEAAFPDCITVQGDGDTVVADFVGDYTKTPDGEFVFVHGPLVRAMRDGVPLFIDDATLIPPTVLAVVYPAMDGRRQIVIKANGGEVVDAAPGFYVVAGHNPGVHGAVLTDALASRFSVQVQVSSDYDLADQLGVDKKAVRVARNLATRQERGEVGWAPQLRELLAFKKIAAVLGTDAAAGNLVGIAPEEDRATVTAVVRDAFGRTVTPLALGARITPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX29</accession>
    <name>A0A7W7WX29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039536">
        <property type="entry name" value="TetR_C_Proteobacteria"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14246">
        <property type="entry name" value="TetR_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21189" checksum="1495E0ACCF39A3AA" modified="2021-06-02" version="1">MPERRRGRPRAGEAAARREAALDAALALLVEHGVDGLTMAAVAARAGSSKESLYNWFDNRAGLLAELVRRQARDVATDLPSGSDSPEALRDRLTTIAENLLLLLVGPPSLAINRAAMGSPELAGLVLRHGRHTTGPAVEAYLAANDIADPPEAFRLLYGLVVADHQIRALLGEEPPTPERVRREAGIAVDRFLRLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX41</accession>
    <name>A0A7W7WX41_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16821" checksum="A03465C1E7D87BB7" modified="2021-06-02" version="1">MTRLAITGHRELSVPTERLVDAALREVVNERDAGELVGLSCIADGADTLFAQAVLDAGGSLVVVVPAAEYRDGLPESHHFTYDALLSSATRVIELDHTESDSEAHMDASVRMIAEADELIAVWDGKPARGYGGTADVVGVARERNLPVTVVWPDGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX95</accession>
    <name>A0A7W7WX95_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine-rich copper-binding protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030785895" evidence="4">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="5">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="20223" checksum="AD25AE90EB58B0EC" modified="2021-06-02" version="1">MRGRLAGLAFVVAIIGGGTAGPAYATAEPGPVHSEPGAGEVLEVPPSAIALMFDQVVDPASVDVTLRSAAGSEQPLGVRRFDGDAVSYPVIGSDLLSDGVYEVAWTAMGTGGTYWFVVDRHAYEAAPQHPGDDAGRAVVVLRATAEAASSGTDVGFYSYAPSLSPFAMPGWSVVGLAALLTGVGWWFSPVRRRKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD5</accession>
    <name>A0A7W7WXD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="5">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="33016" checksum="1689A3670DB5A37C" modified="2021-06-02" version="1">MTPTYEGRPLPRPDEEVVDQGLGFDLGTLMSRRRTFRTFGLGVAALGIAACSSDSDTGSSPTSATSTTTAKATGEIPDETAGPYPGDGSNGPDVLERSGVVRGDIRTGFGDYSGTAEGVPMTLELTIQDLTKDGAPFAGVAVYVWHCTRDGEYSLYGEKIKDQNYLRGVQIADASGKVTFLSIFPACYSGRWPHIHFEVYPTEADITDATKAIATSQVALPKETCDKVYAQDGYRASVSNLAQVSLAKDNVFGDDSAAKQLATVTGDVTSGFKVSLTAGVDTTTKPTGGGVPPGGDGQPSGMPGGTPPGPPPGMTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP0</accession>
    <name>A0A7W7WXP0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme related to lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="14553" checksum="6312EF9E5CCC6301" modified="2021-06-02" version="1">MLRGLTTISYYADDVVEARDWYAKVLGVPAYFARPEEGTPSYVEFRVGDFEHELGIVDRKFAPHDTAGGPITYWAVDDLDASLERLVALGATPHRPPTAYGPGFVTASVVDPFGNVLGLMYNEHYLSIASAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY07</accession>
    <name>A0A7W7WY07_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="53"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="24459" checksum="D4F3F69DECDE08A4" modified="2021-06-02" version="1">MLSRKGRRVARKTVLKLMNTLGLVCKVRRPRRHRSWQGQTGTTAGNLLNREFGASSPDTKWVTDVTEFRVGDRKIYLSPVIDLFDRSVIAYSCGLSPSLELTNSSLRAAIATLPAAARPLVHPDQGFHYQHVTWRRLLADAGLTQSMSRRGNCLDNAVAENFFGHLKEELFHHTTFDTVEEFTAALHEYIDWYNTTRISTTLKGLSPVQYRAQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY45</accession>
    <name>A0A7W7WY45_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-epi-5-epi-valiolone synthase</fullName>
            <ecNumber evidence="8">4.2.3.152</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate</text>
            <dbReference type="Rhea" id="RHEA:44184"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:84187"/>
            <dbReference type="EC" id="4.2.3.152"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.152" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="10">
        <location>
            <begin position="80"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="376" mass="40491" checksum="441F9F469B9B5793" modified="2021-06-02" version="1">MTHDPVLPGWSISAGAAVRYDIVFADDVFDTVNGSLAALSVAAYPATTRRFVVVDANVDRLHGARLRAYLDHHGISDDPFVLETSEETKTLDTVVRVADALDAHGVDRRQPVLAIGGGVLLDVVGLTASLYRRGTPYLRVPTTVVGLVDAGVGAKTGVNHGGHKNLFGAYHPPVAALLDRRLLATLDRRHVVNGLAEILKIALIRDRDLFELIAARGGALVDERLQGDDDLEVLTRAVGGMLDELRDNLWEKRLARLVDYGHSISPALEMKALPALLHGEAVAVDMALSTVVAARRGLLEPRDRDRVLDVLRAVGLPLTHEALDSDLLRAGLAATTRHRGGRQRMPLPTGIGSARFCDDVTEGELAVAAKELGDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY51</accession>
    <name>A0A7W7WY51_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030518440" evidence="3">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34939" checksum="9B20AE5DF71C53DC" modified="2021-06-02" version="1">MRADRLVAALLLLQSRHRVTAADLATELEVSVATARRDLEALSAAGIPVYPQPGRGGGWSLVGGARTDLSGLSAPEAQALFLLVGPAAAVSNEAKAALRKLLRALPQGFRADAAAAADALLIDPARWGDREPTRPEVVTLLQRAVIRRRRVVLSYSGRSGTPSRRPVDPWGLVDKDETWYLLAGTDDGPRTFRVDRISAAEETDEPAPRPDDFVLAREWERIVGEIESRRSRTGATVLVDARYVSVLRSHFGRHCAVEAELPDGRARVRVAAPTPLDIARNLAGWGAGVEVVEPDSVRAELARIGTELLDRYQLEKRPEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY53</accession>
    <name>A0A7W7WY53_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DO-GTPase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045528">
        <property type="entry name" value="DO-GTPase2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19993">
        <property type="entry name" value="DO-GTPase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DO-GTPase2" evidence="2">
        <location>
            <begin position="272"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="533" mass="57766" checksum="1C1836F0FF2C9432" modified="2021-06-02" version="1">MHPIVFLFLLALLCFVGPYALSAILLAGGATAVVIGVVEYGTAVFAGFTPYGAIKHLKITPPEESDSGPDPAYRSYYAGPVLLDYQQVLGHTFTRVWARVVAGKPDEYGNVSRSQVDRVWRWSKTTATPKMLAWPAAAAATVGLVLGVCTAIAFVTVTSLIFLAFLIVLVVGALITAGVSRVLELGLLFLRGITIECPTCHDKVTRPIYRCPECGAAHRKLVPGRTGVLHRTCRCQERLPTLLALGKANLRAQCAQGHPLPLKGLQAPTAHIPVIAGPQAGKSVFMHSAVSRLMQRGGGFEFADERAKDEFETNVQLKVHLDPSSARKTVIARPRAYNVYVGAQGSRSRRLLYLYDAAGELLVNVDGLADSQFLAHTKGVVFIVDPFSMRQVRSGTDRSTLGRVKASNEAPGEVLGRFVEALRERGVRKRGNRIDLPVAVVLTKTDGLRGPTDAGHPYRAMGSRSREARDTAVRTWLEEVGQGDLTSSLDNNFTTVSYFAVSYEDAVTVAEHESVVNDDPAVPLLWLLDRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY74</accession>
    <name>A0A7W7WY74_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="642" mass="72410" checksum="83F00EB220497F2E" modified="2021-06-02" version="1">MCGLVGLVCPDENDAAHARQAVLGALRCQRHRGPDESGTWQGDEVVFGFNRLSIIDIEHSHQPLHWGPMNQPGRYAILFNGEIYNYLELRSELTKQFGAVFATDGDTETIVAAYHHYGPAAVAKLRGMFAFLIWDRERRVLFGARDPFGIKPMYYAAGPGGVAFSSEKKSVLELTHTIGVTPKVDQTAVQHYLTLQYVPEPQSLHDVVHRIESGTSFTLTPGGKPVVERYFPATFRPRAVHGPSDENRLYDEITEALRDSVAKHMRADVTVGSFLSGGIDSTVVAALAKEHNPDLITFTTGFERQGYSEIDVAAESAAAIGVKHVVRPVSAQEMMDALPLITWYLDDPVADPALVPLWFIAREARKHVKVVLSGEGADELFGGYTIYREPLSLAPFDKVPGALRKAMGKVSTKIPQGVRGKDLLRRGALTLEERYYGNARIFLDDQLRQVLRTYDPNVSHQDVTAPWYDQSRDWDPVTRMQHVDLFTWLRGDILVKADKMTMANSLELRVPFLDPEVFRIANQVPSELKLTKETTKHALRRAIRDIVPAHVLNRKKLGFPVPIRHWLKDEMHDWAVDHVHQSQTDRYLDKNAVLRIIEEHRSGVADHSRRIWALLVFMIWHGIFVEGRIRPNVPEPTYPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY90</accession>
    <name>A0A7W7WY90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin-dependent oxidoreductase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02787">
        <property type="entry name" value="MopB_CT_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02767">
        <property type="entry name" value="MopB_ydeP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037951">
        <property type="entry name" value="MopB_CT_YdeP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010046">
        <property type="entry name" value="Mopterin_OxRdtse_a_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041953">
        <property type="entry name" value="YdeP_MopB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF4">
        <property type="entry name" value="PTHR43105:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01701">
        <property type="entry name" value="Fdhalpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="5">
        <location>
            <begin position="121"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="6">
        <location>
            <begin position="644"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="764" mass="83785" checksum="3D01046CF0910F6B" modified="2021-06-02" version="1">MDRNPPEHDIDETRLDVGEPKRWAAGLPGVAVSLKRGVEQMGVVRTATTLRLLNQREGFDCPGCAWPEPQGHRRLAEFCENGAKAVAEEATRRRVGPEFFAAHPVAELATRPDYWLGQQGRLTDPVVLREGATHYEPISWGDAFSLIGEKLRGLPGPDQALFYTSGRTSNEAAFLYQLMVRSFGTNNLPDCSNMCHESSGAALSETTGIGKGSVSIADFDRADLIVVVGQNPGTNHPRMLSALESAKRNGARVVAVNPLPEAGLLRFKNPQNVRGVVGRGTALADDFLQIRLGGDQALFAAAGNLLLSWDAADADFVAHYTDGYADYVEQTKALDWAAVDEATGLPRAEIEHFARLLADSERTIFCWAMGLTQHKHAVRAIREIANVALLRGMIGKPGAGLCPVRGHSNVQGDRTMGIWEKMPEKFLAALETEFGITVPREHGHDTVASIRAMRDGTAKVFFAVGGNFASASPDTAVTEAALRSCELTVQVSTKLNRSHVVHGRTALILPTLGRTEADLQHSGEQFVTVEDSMSVVHRSRGRLTPASDRLLSEVSILCRLARELLGPDHPVPWEDFERDYDLIRDRISRVVPGCADYNERVRRPDGFVLPHAPRDAREFTGTRSGKAHFSAHELEVLKVPTGRLLLQTLRSHDQYNTTIYGLDDRYRGVKDGRRVVFVSPADLDELDLLDGHYVDLVSEWPDDPTGIVERRAERFRVVAYPTARGCAAAYFPEANPLVPLDSTADVSGTPTSKSIVVRLERLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ1</accession>
    <name>A0A7W7WYJ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031389008" evidence="2">
        <location>
            <begin position="25"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="548" mass="57143" checksum="1AF50E7E4A9D680B" modified="2021-06-02" version="1">MSKNWVAAFGCVAALLAFGGTAAAQPTTGEAPGLPGTVAVDVRLKLERDGALTVTEVVAVPEGRTAGRTVPLRIAVGDGRDRVFTVTDAKVDGRGTATADAEQLSLALDGGTSTVSYRVVGAVAKIGDALELRWQPASGWNTDLDSVKVSVITPDMPRSVNCLAGPPGTSQPCSSAELGDGRGVRATEFGLAAGERVDIAIGLQDGAAPPNARVEESSTLASAFALTPATGLGLGALALVLLVGVGLLWFLRGRDARALAGDVAPVRVLVDDGHGHVAFASPDGVLPGQVGTVVDEHVDVVDVTATAVDLAVRNYVWIEEVGELDWRFVRRNPADASLSGYERAVYDAVLPAGTDAVLLSELRGRRIDLSAVRHELYADVVAKNWFARRPDAERSLWWWVGLGIGGVGLAAAVVFVVTGGPALFGLLVAVAGVAVALGARWMPARTKRGSVLLEHVRGLRGYLVTATPADVPAADREMVFSRSLPYAVVLGEAERWLGAFAGEQAGLYWYGEAERTADLRRFAGRFPAFLGAVDGVLAQAGHLRSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE3</accession>
    <name>A0A7W7WZE3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system LytT family sensor kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="281"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="416" mass="45705" checksum="6BC200478242392B" modified="2021-06-02" version="1">MPDLLTGRLVLGVIATMAVCGLFMMLCRARRVSTSVEDAVMDMLARMSKASADLREGLTEDSANKATPHLREMLRCVAVGITDHEGTLLSWDGEANDHYEPLQDYIESAIGGGHKEHVEHRKLDCELPGPCAMHSAVIVPLEVEHEVAGTLIVVSGVPNKRQITMAEETARFVSTQLELEVLQKSRQALAQAEVRALRAQISPHFVYNALNTISSLIRTDPAHARELLQEFAEFTRYSFRTDGLYTTLSDELTNIHRYLTIEQARYGPRLNVRLKVAPEVLHVVLPFLALQPLVENAVRHGLAKKPGGGLLTIIAEDNGSEALISVEDDGIGMDPERLFEDLKDAHTTGAHVGLGNINQRMRSAFGDDYALVVETAQDAGMKIILKVPKYSPGVQTNLPLVPPRLEDTTEQEVVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXB4</accession>
    <name>A0A7W7SXB4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cu+-exporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="735" mass="76226" checksum="6B855BBDD32EEFB1" modified="2021-06-02" version="1">MPTAETGHVELAITGMTCASCANRIERKLNKLDGVTASVNYATEKATVDFPVGLDVADLVSTVRAAGYDAAAPRPDATEDVDDEAGGLRLRVGIAAFLGVPVIVLSMAPALQFPAWQWFSLALASVVVWVCGWPFHRAAAVNARHGASTMDTLVSMGVVVAYLWSVYALVFGDAGMIGMRHGFSLVPRPTTSGDIYLEVAVGVTVFLLFGRWLEARSKRRAGAALRALLALGAKDVGVLRDGVEARIPVERLKVGDRFVVRPGERIATDGVVDDGVSAVDRSMVTGESVPEEVGVGDRVVGGTVNAGGRLVVRAAKVGADTQLSRMAALVEQAQSGKAQVQRLADRISGVFVPVVLVIALGTFAAWLLAGRPVEFAVTAAVAVLVIACPCALGLATPTALLVGTGRGAQLGILVKGPEVLESTRRVDTVVLDKTGTVTEGKLDLVDVVPAEGVSREELLRVAGSVEDGSEHPIASAIVRGAGVEVGTLPTIGEFRNVQGVGVTGVLDGRRVFAGRTGSAALTPELKERADELRALGRTVIAVSVDDAPFGLLSVSDRVKPTSAEAIRGLRALGLRPVLLTGDNEVVARAVAAEVGIDEVIAEVMPADKVAVVERLRARGRVVAMVGDGVNDAPALAAADLGLAMGTGTDVAIEAGDLTLVRGDLRVAVDAIRLSRRTLGTIKGNLFWAFAYNVAGLPLAALGLLNPMLAGAAMAFSSVFVVTNSLRLRGFRATAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXF3</accession>
    <name>A0A7W7SXF3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="51086" checksum="FBB76D2575B3451D" modified="2021-06-02" version="1">MSRESESEQTTRTVAELLAQYGGASGDAQPRRRRRRAAEDASDTAPQSIIDRVNSDSGRLLPIRDEPPPAATPPPVAPPPITPPPAAPPPPPASKRGRSSPPRRPEPERTTYAPPVRTDPAPTSRMDPVDLPRRTGEPQRHEPQRHDPFGAETFAGGDPFDGPETGPSRRAEPGAARPFGGPETSSSRLDPMVGPEASSPRLDRRAETSSSRLDPVRRAETSSSRLDPVRRAETSSSRLDPFAGAPRRGVPEDAAERTSVVPPIVDDFEPPRRPGPPPLPAREPVTEVMPRIDERPDLPLEARPTESVLIVPPAPARMPDPIPGQSPEDWFGDDEPQPRREGIEQEGTQFHPYVDLDEEDDRGPAGLDDEKPAGLADDDEEDAPARRSPGKEWALMIGQLAIGIVGGAALWLGFSFLWRTLAPAALVVALAVTVGLVLMVRKIRRADDLQTTVLAVLVGLIVTVSPAAMLLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXG8</accession>
    <name>A0A7W7SXG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="34" mass="3891" checksum="5A168427145E8F8E" modified="2021-06-02" version="1">MVPQIEDEVAVRGFLRAVQADEVEYDRDVLALIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXV4</accession>
    <name>A0A7W7SXV4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">F4559_000268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010148647.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="37" mass="4403" checksum="34883E7EBBFEF0C8" modified="2021-06-02" version="1">MKVQPSVKKICDKCKVIRRHGRVMVICENLRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY74</accession>
    <name>A0A7W7SY74_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_000489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27360" checksum="2A796714BF61C2E7" modified="2021-06-02" version="1">MPDDLTLALRLADAADAITTTRFRARDLVVERKPDRTPVTDADTAVEDAIRVILAAEAPDDAVAGEERGGSFDTGRAWVVDPIDGTKNFLRGVPVWATLIALVEDGRPAVGVVSAPALGRRWWAAAGAGAFTLDAAGERRLSVSGVQDIGDAYLSTTHLSSWVEYHSREAYLRLADAVWENRAFGDFWQHCLVAEGAIDIAAEAIVNPWDVAPFEVLVTEAGGRFSAVTGEPGFALGSALSTNGHLHDTAVELLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYL3</accession>
    <name>A0A7W7SYL3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="29368" checksum="63F39C5724F5C80A" modified="2021-06-02" version="1">MTRRDQLRDFLRTCRARLRPDDVGLVTAGRRRTPGLRREEVAALAGVGLPWYTWLEQGRDITVSTEVLDAIARALRLSGPERTHLYLLAGLNPPVEGGSRDADVTPELRRLVDAWHPNPAILRDRCWNLLVVNEAARTLFGYAETDRNCLIAFFTNPRHREAHTHWTAVAPLVVAAFRADAAHFPDDPGFAAVVADLVDRSPEFARLWARHEVGRPGQTVKAVRHPEAGELLFDLTTLVVADRPDRYLELYNPRSLVVGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ06</accession>
    <name>A0A7W7SZ06_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">F4559_000927</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="236"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="355"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="367"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="612" mass="67507" checksum="5792B750FBDA53BC" modified="2021-06-02" version="1">MVLAELRELAGQLGITATAGLRKGDLIAAIKERQGGTSGRGGAATPSKSDKKAAEKPASVEAPAAPVVEKAPEKPVQQQLDVTDRPAAEEEGGRRGNRRRRSANRPTGSPEAAASTTAPEAPATAPAEQQRPERVERPERGEQREQRQERGERGDRGERGDRNRGRDRDRDRDRGRDRDRDRDRDRDRDRQNVAQDEDDEEGGRRGRRFRDRRRRGGRGEDTGRSTDTEVRDDDVLLPVAGILDVLENYAFVRTSGYLAGPNDVYVSLSLVRKYGLRRGDAIIGAVRQPREGEQQRQKFNPLVRVDKINGLDPEESRNRPDFTKLTPLYPNERLRLETEPHILTTRVIDLVMPIGKGQRALVVSPPKAGKTSVLQSIANAITTNNPECHLMVVLVDERPEEVTDMQRSVKGEVIASTFDRPPSDHTTISELAIERAKRLVEMGHDVVVLLDSITRLGRAYNLAAPASGRILSGGVDSTALYPPKRFLGAARNIEGGGSLTVIATALVETGSAGDSVIFEEFKGTGNAELKLDRKIADKRTFPAVDVDSSGTRKEDLLLSPDELAVMHKLRRVLHALDSQQAIDLLLDRLRKSRTNIEFLMQVAKTTPGSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB0</accession>
    <name>A0A7W7SZB0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS family solute:Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="560" mass="58917" checksum="4E86BAE2E313966D" modified="2021-06-02" version="1">MVPLAEADLRLDAGPLDYALLALYFVFVLGIGFLARRSVTSSLDFLLSGRSLPAWVTGLAFVSANLGAIELLGMSANGAQYGMATVHYYWIGAIPAMVFLGLVMMPFYYGSKVRSVPEFLRRRFGTGAHLVNAISFAVAQVLIAGVNLYALALLLNLLLGWPIPLSVVAAAAIVLVYTTLGGLSAAIYNEVLQFFVILAALLPLTIVGLHKVGGWQGLVDKVTAGPGGADQLSAWPATELTGISNPVLSVLGIVFGLGFVLSFGYWTTNFAEVQRALSAKSMSAAKRTPIIGAFPKALIPFVVIIPGIIAAVVVPEMAALKGGEATGVTYNNALPLLMRDLLPNGMLGIAITGLLASFMAGVAANVSSFNTVFTYDLWQSYVRKERPDGYYLKVGRIATVVGVLIAIGTAFFAAGYGNIMDYLQALFSFFNAPLFATFILGMFWRRMSAAAGWSGLVAGTLAAVGVFVLAETGVLDLPGQGASFLGAGVAFAVDIVVSVAVTLVTKPVPPERLTGLVYGLTPKKDREHDTSGENAGWYRSPALLGGAVLVLTLLLNIVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZH0</accession>
    <name>A0A7W7SZH0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTMP kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23507" checksum="1C84B69BD302872C" modified="2021-06-02" version="1">MGKLVVIEGLDGAGKRTLTGKLTAALAEAGLTAVTGAFPRYDQDIHAELVRDALHGRLGDLTDSVYGMAVLYALDRRAAAPDLRAWTAEYDVVLLDRYLASNAAYGAARLRQDVDGGFVEWLRALEVDRFDLPVPDLQLLLRVPTEVAGDRAARREAQDARERDVYESDADLQTRCSIVYDRLAQTHWLSPWAVLDGTEALQVDDLVQEHFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZV4</accession>
    <name>A0A7W7SZV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase (GGDEF)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="112"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="30425" checksum="8DBFD72CC682DA4F" modified="2021-06-02" version="1">MTALRPEIVEPDGLADGPDLVHLHESIATLLAARGQWRQAYRHLRSAYDLAFAEQDVRPMVPEQLRREVDRLRREHAEAREQSLRDSLTDSYNRRYLDQRLVSLVAERGGGAELAIALVDLDWFKQVNDTFGHLLGDRVLQNVVELLQVDLPDGAFCARYGGEEFVLVLPDVDAAEAVRIAETTRSRVERHAWDSLAPGLRVTVSMGLACEPPAGDASTRPAVAPEQQLLRADSLLYSAKQSGRNAVAYREGGRVRLAGPASGRRGITEPRVAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T000</accession>
    <name>A0A7W7T000_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">truB</name>
        <name evidence="9" type="ORF">F4559_001403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015225">
        <property type="entry name" value="tRNA_psdUridine_synth_fam2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09142">
        <property type="entry name" value="TruB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="8">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C" evidence="7">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="28826" checksum="0ABFC098E9C00C87" modified="2021-06-02" version="1">MTSHDVVARVRRILGTRKVGHAGTLDPMATGVLVLGVERATKLLGHLALDSKAYLSTIRLGASTTTDDAEGETLATADASAVPEDAIRAGVAALTGEIDQVPSAVSAVKIDGKRAYARVRAGETVDIPARPVTVHRFDILAIRREGETTELDVMVECSSGTYVRALARDLGAALGVGGHLAALRRTRVGPFDLRVARTLPQLEEAPGLSLDLDAAVSTAFPRREIAPREAVALSHGQRLPAGGLTGTYGVFGPDGHVVALAKDEGAVAKALVVLTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T034</accession>
    <name>A0A7W7T034_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20007" checksum="6046F5A83298BE65" modified="2021-06-02" version="1">MTEQPVDDRVVVYHYVPPRPRVVVKRDLLPAFSVLSTTALFGLPLGWVWAWLAPPQNVIVAQDGSLVPVTGESYHRLDGLMIFVLMGLGAGLLTGIAVWLLRSRRGPVVMVGAVLGSGAAAFLGQRTGVGSAAGRYAVENAPKVGDLLLKAPVLESWWGLLAWPLGASLAYGCLAAWNGLDDLGRRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T041</accession>
    <name>A0A7W7T041_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="13" type="ORF">F4559_001225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="9"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="343"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="496" mass="54216" checksum="E9D43CB20CCD24AC" modified="2021-06-02" version="1">MSATAAPSEVRVRFSPSPTGTPHVGLIRTALFNWAYARHTGGSVVFRIEDTDAARDSEESYNSLLDALRWLGLDWDEGPEVGGPHAPYRQSQRREIYADIARRLFEAGELYESFSTPAEVEERRKAAGQDPKLGYDNFDRTLTDEQKAAFRAEGREPVLRLFVPDEDLSWVDLVRGEITFKAGSTPDPVLVRANGDPLYPFTNPVDDALMGITHVLRGEDLLPSTPRQIALYHALIRIGVTTFTPRFGHLPYVMGEGNKKLSKRDPQSNLFLYRDRGFLPAGLLNYLALLGWSIADDRDIFSVAELVEAFSLEKVSANPARFDLKKAEAINATHLRALPAAEFVTLAVPYLVADGVLPAEPSAEQLAVLSGVAPLVQERLVVLSEAAGMVRFLFAAEEDFAPEEDSAAKALGADAVPVLEASIAALETVPEWTAAAIEEALKVSLVDGLGLKPRKAYAPVRVAVTGRTVSPPLYESMELVGRDRSIGRLRRALGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E9</accession>
    <name>A0A7W7T0E9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19672" checksum="EEAB0A5002E2BAA6" modified="2021-06-02" version="1">MTASATGTHIHPPKIEYFDLDAKSNTDPKGHLRGVEEFRLTRHGLYMSRPVAGHPRLAHFESWFLPAHGLRVTRQSWHPGHEPDYDLYVDIVEITSGGSVWKTVDLYLDLLVRTGRGVTVLDTDELLTAVTAGYVRPDRARWAFETVYRAVDGIAAHGHDAVRWLAACGTVTTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0F3</accession>
    <name>A0A7W7T0F3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="952" mass="102860" checksum="A252273177D6B764" modified="2021-06-02" version="1">MEYDGGEPLRFEVLGLLRVVRGDREVDLGAAKQRAVLAVLLLARNTPVSRDQIIEAVWVDSVPSSAVNLVQTYVAGLRRALEPSRARRAPAELLTSVGDGYRLRVDPAAVDLDLFERAVAASTRARGSGDLVGATRHLDDALALWRGEPLGGVAGLFAEVERGRLIERRLAVLEERAELMLLIGRGAELVASLGSLVGEHPLRERGYGLLMRALCQAGRQAEALGVYREARRVLIEELGVEPGPDLRRLHQSVLAGENPEPEPPTRPITLPAAVVEPQLPTTPAQLPRAPVSLIGRDLLVDRLDGLLGEHPGGGLVLVVTGPAGVGKTALALHWAHRAREAFPDGQFYVDLHGYDPNQEPLGAGEVLNRFLRTLGVPSADIPVTVEERSAMFRTLVADRRMFVMLDNARGSTELLPLLPGSPSCVMVTSRRRLVGLVAHAEARLVELDMLDQDAAVAVLERVAGRAGTEPAALRRLAVLCDGLPLALRIAAARLAVSPTLRAAELVAELDDEHGRLAALGLEDEDSTVRAALDASRRALSPLPARLLALLGLHPGPDVTPYVVAAMARVRVSEAQRALDALTAANLLSVGEAGRYGAHDLVRVYTRTLAAELTTAQAHDATQLMLDFYLHCADLADGLLPTGRGSVRVAPVHVPAEVPRLTGSADALAWLDAEQINLIAAAELAGEGGDRAWLVHAWQLPYTLSRFFFLRTDRSTWLRTTEAALRAATALGDPEARFVMLFNLGVALAQFHRTDEALARHREALEVARSSGDTNAQARALTTVADMLRNLGRMDEAEACYREALDVSRAVGSRWAEANAHHNLGFLYLRTRRFADARKWLSAAVEMYREVGEQCGESMCHTDLATVYQESGELAEAVESARTALSVASAASSPYHQALAHDRLAEVFDHQRRPGALSHWQRALALFTELNAPEADQVRARLARTRAGAPNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T5</accession>
    <name>A0A7W7T0T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31213" checksum="7919BF1AF9E10284" modified="2021-06-02" version="1">MVRSTPKAMALGAKIRTERETRSMTQRNLARKLGLDSGTMSRIETGERPPTAELAAAILGALGVTGERREEILTLARGDNTSGTAWVAVGMPEQRTQLDALLQLEQLAGVVVDVNPLVIPGLLQSSGYTRAVMRAARVPDNEIETRVAIRMGRREILTRPNPIKFTALISANVLRQSVGGPDVMADQLDHLLGMARLDNVELRAFPVETDWHDGLYGPFTVLTIAAGRSVVHLENRVSGLFIQDDHDVADFEDAARRVRDMSMSEEATIDLIEHEARRMKKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X0</accession>
    <name>A0A7W7T0X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type phosphate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="262"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="545" mass="59085" checksum="3AC68CE5C4C2E3C7" modified="2021-06-02" version="1">MQTLRSALDFLGGPGPVALAIALLFATPVIDRVFVRRKRVNFRVLYNSKIGLGPEQLHDGTESQPSQLRELVRVLDRMSIVVVRVRNSGNYDIDADDWDKALTFTFGERVVWNARVSEAGSDDLREEVRRSLQFFGADTARRVSLPTVRERMAQLVARWGRLAVVAEPGEQVWHGVRLEGLALRRKQKFKLLVVLREPETNDGPIGKDVRIEGRLGGVGIVHDEKRRRVVTLPRLTGGIAAVLAAVLVLTLAWPGQSSDPTVACASGSLKVTGSSVFLPTVRPIVDQYRAACPDADITVESTGSKEGAREVAALGPADTGSVLAFSDGAPSDADVTGRRVAIVVYHVVVNGSVGLETVTLDQLRGIYAGRYRNWSELGGAALPIRVVGRDGDSGSRQLFERVVLKAAEPAISSDDCRVADRDPTASVIRCERPRNADVVREVGATEGAIGYADAPSVAEPRKAKKIVALSLDGRAFDAAAGVDEGYPFWTVEYVLTKGQPAEDSLSGRFLRYLLEHDDARVRMKDAGYLPCRTADGDTLSLCGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T156</accession>
    <name>A0A7W7T156_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21339" checksum="E4B396B524016F38" modified="2021-06-02" version="1">MGFREDRSSGLRESAPVDDRGIAAAVGGDRRAIERVLAWIRPVVMRYCRGRLGGNAQACDDVAQEVCLALLRALPGYRDQGRPFLAFVYGIAAHKVADAHRSAARNRAEPVAELPDAAGTDAGPEQLALRGELSDDMNRLLAVLPAKQREVLVLRVVVGLSAEETAAAVDSTPGAVRVAQHRALTKLRAALAGDRSALVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B7</accession>
    <name>A0A7W7T1B7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000839</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="8"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="22615" checksum="334C15EC5B18A159" modified="2021-06-02" version="1">MDSGSVPISALEHYAYCPRQAGLIHVDGYFESNVDTVRGDLAHATVDRPGPDTDRRGHRVWHSLPVWHDELGLHGICDTVHLAEDGPVPAEHKSGGYRPGGPADLQVAAQVLCLREMFDAPVPIGLVFTGRDRRRHEVVVDHELADRVARATEEIRRMRDTAVLPPPVADTRCRRCSLKPGCLPETTVAVRAGLFVPREVGDWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1C2</accession>
    <name>A0A7W7T1C2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="23058" checksum="5C8605DB714597AA" modified="2021-06-02" version="1">MDDWVEDTRTSYDTVAVGYAEYVRASLAKQPYLRSALALFADLVREAGGGPVADVGCGPGEVAAHLRGLGVDVFGVDLSPGMVDLARRSHPDLRFEVGSMTELDLPDGSLGGLLAWWSVIHVPDEEVPTVFAHFHRVLRPGTPVQIGFHVGDVSRLKTEGYGGHPMRVHVHRRRPERVAGWLRDAGFEVEAHLVVDPDKEVPGAVLCARRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1N0</accession>
    <name>A0A7W7T1N0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="499" mass="55139" checksum="C80AE9FF0E6D5C26" modified="2021-06-02" version="1">MLAADNTDRLCHRCRRNARSELYGPPTLPDEFWDDEILAPAFADRSMGALLAAYRHHPRHVSRVTQDRLASWLGISQAQLSRYETGENPIERIDRLRHFARQLGIPTDRLWFDRVGVPSQAGVPERVATPHVLAAAWDAASIARSVEETARNDLAISRRAALSGAAAVVMGPTLVEPLQRWLHPLQPLSKWSSSAAISEEELTALQHVADGLRGWGGRGGYGLARKAVLGQLEELAERLAHAPAGPTTERAFFIGAELSKVAASMSWDAGMHDAAQRYYVLGVRMAKAGRNDPFAALCLAAMARQMFDLNRPEDGLELVQLGQYGTRRNSTPTLQALLLTREAWAYAQMGQVREFDRAVGRAQDCFAQREAGAEPWWLDSFDEAELEGVIGARMRDLAGHDPRQAPAAEQHIRRALDLRDPRRVRNRTFDVIGLARTKMVAGEPEEACGLIQGVLPIASGLASGRVHRKLQDFAVEAERHRDLPAVRDAREAIRGVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q8</accession>
    <name>A0A7W7T1Q8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="454"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="643" mass="70537" checksum="A669DBB83D83D1FC" modified="2021-06-02" version="1">MTGYRYGRYVDGPDPLEPPADLRSAVDELGREVMEGASPESALRELLRRGVDGTTGLDDLTARVWRKRAAIQRRHRLDGTLQEVRRLLDEAVAAERRELFPDPDDDARFREAVLDALPPGTAAAVTELASYDWRSAQARESYEKIRGLLGRELLDQRFQGLKQAMETVTTEDVDRIRRMLDDLNGLLADHAAGRDTTERFAGFMRRHGDFFPENPRNTDELVDALAARSAAARRTMNSMTEEQRRELAELGSQAFGDPETARQLSTLDGLLQGLRPGEDWTGSARFRGDRPLGLGEGAQAMADLAELDALAEQLAQSYPGARLEDLDLGALVRQLGPAAGVDARRLAELERLLRNQNLLERAPDGTLQLTPKALRRLGETALRGVLDSVRARGNRDSARAGAAGEPTGATRPWAFGDTEPWNVPRTLTNAVLRTGGLGLDVVDVEVDETEQRARAAVALCVDTSWSMVQDGRWVPMKRTALALHHLISTRFRGDALDLVTFGRHARTVDIGELTALEGVWEQGTNLHHALLLAGRHLRRHPDARPVVLVVTDGEPTAHLEADGTADFSYPSTPRTLARTVAEVDALSRLGTALTVFKLGDDPRLAAFVDMIARRAGGKVVSPDEDGLGAAVVSDYLSSRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U3</accession>
    <name>A0A7W7T1U3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="30004" checksum="C2C8AB90B421877F" modified="2021-06-02" version="1">MSTASGPFRPGDRVQLTDPKGRHYTIVLEPGKEYHTHRGALPHDKLIGQPEGSVVVSVGGTSFLALRPLLPDYVLSMPRGAQVIYPKDAAQIVMYGDVFPGARVLEAGAGSGALTCSLLRAVGEQGSVTSYEIRQDHADHAVRNVEQFFGGRPGNWSLTVGDLADHEGEVDRVVLDMLAPWDVLPTVARSLIPGGVLVVYVATTTQLSKVTEALREQQHWTEPQAWETLVRPWHVVGLAVRPEHRMIAHTAFLLTTRRLADGVTPPRPQRRPSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W2</accession>
    <name>A0A7W7T1W2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="719" mass="75985" checksum="09F8FBAAFC30DD56" modified="2021-06-02" version="1">MVDREPTPAPPQFTVSFAGPTMVVGPPSGVGTRAANLARTLPADPGRTVVVVDAPGDEAAFWPAVAAAVQGRGPIRLMSSFSGSMRPTAPAQWLAEQLQTEVVAPDGVVTTVPGAVFVSGNGGYGAWLRFQPGASPMPLGRRFPVPQWEAVDPNVPWPTGDVGLSEPVPAGLWLRAQRGDWDGRAVVNLPCRDNVLTVVVGGPGQPQIPVDEVCRLLGGLPAVARSRVRMVWYGGEDEAQAVADRLGEPISLYTGLPIGSTRTGAAVVAVNPSGQQTWRPYVTEVRHSPGEGPVVSGYRTPVQGLVERGPGVFDLGGGVVLEVVPSGLWVREAEDNGSEVRALPVDPEWARLTVGTPGRTTAGAVAVAGASLVERLEPEVRRLLKVVFCDPTPLPSPPVATEEPEPEFEEELPPPPSFTPTPVPSFTPPPVATLPPVPTPSPVPTPSPVPAAPPTPVAAALPVSTPAPEEPPAEEPIALSVDGPLSPSPMPVWGERPGDEFVPSDHHSTEQERDALRRMLGERYGEHAAVACRHLEERPENGEAFEAVVTDLAAVSAFLQQDEEVMVETFRTGRLGRLRPYAAGVVSGLRRLPVHQGVTVCWGDAQRFRTGDILVEHGVLDTVSGPGVPVDGRAEFLIWSTTGKQVNVVDSFGSVVQRRVLFPPGTAFKVLAVVEPEESAPMQVMVYEFLGKHQDLPSGVLGHLERAAVALRSSARAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T258</accession>
    <name>A0A7W7T258_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="2"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="318"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="561" mass="59974" checksum="79280B50BA12396A" modified="2021-06-02" version="1">MALVLLLQLFGVVASLYLPSLNADIIDFGIAHGDTGYILSTGGWMLGVSLVQILCSVGAVYLGARTAMSVGRDLRAAVFHRVGGYSARELSAFGPSSLITRSTNDVLQIQTLVVMTFSMLVAAPIMCVAGVVMALREDAGLSWLLAVAAPGLALAIGLIMIRMVPNFRHLQVRIDAVNRVLREQLSGIRVVRAFVREPVETRRFGDANAQLTDIALRIGRLQAMIFPIVGLAFNASSVAVLWFGAYRIDAGAMQIGAMTAFLSYLMQILMAVMMATFVSTMVPRAAVCAERIGEVLDTESSVLPPDVPVTELPAKLSLEFSQAGFRYPGAADPVVTDVSFRAEPGRTTAIIGSTGAGKTTLLSLVPRLVDVTAGAVLVNGIDVREIDEDTLCARIGLVPQRPYLFTGTVASNLRYGNPDATDEELWAALEVAQARDFVEAMPDGLAAPISQGGTNVSGGQRQRLSIARALVRRPDIFVFDDSFSALDLETDARLRAALRPHTANAIVLVVAQRVSTILDADRIVVLDEGRVVGIGSHHELLDTCPTYVEIVQSQLTTEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2I0</accession>
    <name>A0A7W7T2I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NHLM bacteriocin system ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="113"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="422"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="456"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="675" mass="71171" checksum="0AE6BA1CD7A64249" modified="2021-06-02" version="1">MSASPVDPSAVLRSHARRSGIRLRRTRLDRGWGRRDVGPLIGTRADGTGDPVPLVFARGRYHVVHPLTRARTPVDATAFADSAAAPHLPLPARARLRHLLRRGLTGNGRDLRGMLVAGALVAVLHLATPLIIGRVLGGLVRGDLRGIAWDVVLYLATAVAAALLEVVLNLRALRFEDRFEANLHLAVWDRLLRLPTGFFRGTTSGALANRVLGVAHARQALDGVPARALLALCTACAGVGLLLVVESALTWVGFGLVVGTALVSTALGAVVVRRQRAALPAEHRAASVTDEVLAGVTTIKTAAAEPRAFGRWAEAAVAARAGVRRVRRVQAGFAALVTALPIGTQLVLLAVLSGPLSGQVPADRFFTANAGLALLVQATITLCAAGVDVAAALPRLEEVTDVLAASPESEPGARQVELAGGIEVCGVTFRYPGSDKPVLDDVSLHVRPGEFVALVGPSGSGKSTLLRLLLGLERPEAGTVRYDGYDLAALDVGAVRRQCGVVLQDGRLFGGTLRENICGADPLPLEEVWEAVRWAGLEEDVRRLPMGLHTVVPYGGGTLSVGQRQRVLIARALAAKPRVLFFDEATSALDNRTQELVTAGTRRSAATRVVVAHRLSTVRDADRIFVLDRGRVVQAGTFAELFADAGGLFHRLAARQVVGAHLAVGSAGRPALEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U3</accession>
    <name>A0A7W7T2U3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031430283" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="9744" checksum="8FF544B718911DFC" modified="2021-06-02" version="1">MRPLLISALVAAAVLVPVSSASAADYTVHRSAIGSGTARGFTAAVELAAESAHRAVLAEGGDCVGWQHELLRLEEHPHTLLVFATIKASAVCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y0</accession>
    <name>A0A7W7T2Y0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family metal-dependent hydrolase/uncharacterized protein (UPF0248 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MJ1316" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="828" mass="88222" checksum="8974DAF4D73D78CB" modified="2021-06-02" version="1">MRTSEQVYHQVRWDSRLDPARFVVGVAQRGREPKRVPFAAFMPGGDVPWHRVLFLEADGEVVWDRAAGIDRVAESGAGRVRRGRRLRAPFTPAEPHGHAAGGTGLRVLTWNTLWDRFDRELIHTARRRPLLLDLIAAADADVIALQEVERDLLAALTRHLPGYALDADPARVEDTGLVLLSRLPVLESARLDLGPHKAVHAIVVDAGDPVTVAVTHLTSDHTAGGAAIRTAQLAVIAEALAPVEGDVVLVGDFNHGGTLPVLGMRDAWTELHDDDAPTFDPVGNPLAAVSSLSGRSARLDRVFVRGTAAVLRADLVGTRPVDGLFASDHYGVVVDLGPRPAESDVLDVPPTPRTAVVWLPGPWPEVDAVRESTRWPPHVTLLFGFVPESDFDRAVPLVADAVEEIAPFPVRVEGVGTFGDVVWLDPAARPAPWAELHAALLRRFPACRARFTPHLTVGTTERAAARIPGRDFGVGEVVVLSRRGDGPMLPRAVVGLGTGEVRWIEEPPTPPGPDLDAVADRVVAALPGVHVVGSRAIGGHLPDADLDLVAPDPPLDRVRALGVEPVPVVGARTPGYRFAVSGLSVDLLASDDDIATGAITDAAAVRAAVGERHASFVRVVRVVKAWARARGVDSAPFGGLPGLAWSVLAARAVCAGTEFFATWAAWDWHDPVALHGQPARTGEAVTVLTPTAPIRSCTGQVTPGFRDLLTRELFRAWEIVESGDLGTLCAPPDGHRVHAAWAVVTTPVERVGLVRGRMRALLGALEPHVAEPHAWPRPIAHDPVRFAVGLGPTPPSPATLADLVAPWVAGLPDVEVAWTGNGSVPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z6</accession>
    <name>A0A7W7T2Z6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="41382" checksum="6CEC6FF7DBAB7F20" modified="2021-06-02" version="1">MSQAERARELRERRQALRDSWRPRDRYVIGGVNWPGHSHEAMHRMVHEDADPAQVDGVAAEWRRHGDAIVELADRFRELLGDLESAWRGPATERAFEVLRDNARWVAELGETVSAISVPVTESAQALASARAAMPEPQAGPDGWAAVGAASATSTLFAAAAGPAGAVVGAVVGAGASVVGQAAGRWELKARAVEVMRGYELTAQAIDASAPGFGSDRPAGPWLGDRVPSGPGGGGPGGGDPGGGDPGGGDPGTPVDEDDPPTGGGSDDPGRGVTAVVPDDVTVPTWAAGPEARWQALTSATPAPTTPAPVAPTHAGVPAAAYPWQAGGNRGLGAGTTTGLPGERGGPRPSGDVRAGARGVTGPGMSGGMVPAAQREEEDREHHNRYPDEHDVFADDQVVAPPVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T332</accession>
    <name>A0A7W7T332_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">1,2-phenylacetyl-CoA epoxidase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="27947" checksum="105C2C9A042E8D08" modified="2021-06-02" version="1">MTTATSPASTDSGRTLKDEIIERYGEPAWHVILTIYVNFYYSELEIIDLCGRWIPIRGDLREKNYLLRHAADEVVHARLFQEGVEKLGQPWDGFDHDAYRIPDIDARFDKLYVSDDELEVLIGLNLYAEGVLAMEELAQLARNKPEYFYQFGRIEREERRHVAFGVTVAKRLVAESEENRQRALAHRRWYREHLENYLSGQLKDSIQWGIEAGFVGDDYIQRTRQRFDDVFAKIGLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3A1</accession>
    <name>A0A7W7T3A1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="24672" checksum="9879FADA159F5773" modified="2021-06-02" version="1">MPPDFSKETVDRWQVFGGMAGVAALAVSAIGGLKDSLPLSLAAGGVVTLVGVLLLYRWGRQAGFQRFLIPVVVTLIGALTTGFLIARNLSPSTSGTGTTGSASRTTAKSVAPAAAGEPARFREGRVVLNEYSWVDLDSHGESGGVGSGSPASNGHDLSYSYGLNAAERLAVVSAESPGYRDCYEATDLRTYLDGDTVKRGPAFCVKTSEGRWARVVVDASGWPGSVTLDVVVWEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C1</accession>
    <name>A0A7W7T3C1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.60" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018480">
        <property type="term" value="F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901023">
        <property type="term" value="P:4-hydroxyphenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011985">
        <property type="entry name" value="DH_HpaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02299">
        <property type="entry name" value="HpaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="491" mass="52735" checksum="FCA77969D3B8CC4E" modified="2021-06-02" version="1">MSIPTELLHHIDGKDVPSVSGETFAVADPVGNKEYGRVAAGDKADIELAVAAAKKAFEEGPWPRLSDRERANVLVRIADAIEARSERLAELETFDTGLPVTQAKAQAHRAAENFRYFADVIVGQHEDAFLVGEKQVNYAVRQPAGVAGLITPWNTPFMLETWKLAPSLASGCTVVLKPAEWSPLSASLLPEIMKEAGVPDGVFNLVHGIGEYAGAALVEHPDVPRISFTGESGTGQIIMRTAANNLKEVSMELGGKSPCVVFEDADFDRAVDAAVFGVFSLNGERCTASSRVLVQRGIYDKFVAALAERAKNVRVGLPSDPKTEVGALIHPEHYARVMEYVEIGKTEGRVVAGGGKPEGLPEEGNFLSPTVFADVPPTARVFQEEIFGPVVCVTPFDTEEEGVELANATKYGLAAYVWTANLQRGHRVARAIQSGMVWINSHNVRDLRTPFGGIKASGVGREGGAHSIDFYSDTRAIHVAVGDLKPPRFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3H8</accession>
    <name>A0A7W7T3H8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="35140" checksum="2194CAAD80BF1059" modified="2021-06-02" version="1">MRADRLVSLVLLLRQHGRLSATALARELEVSTRTVLRDIEALSAAGVPVFAERGRLGGFTLLPGFQTELTGLNHDEALALLVAGSRRGAQAFGLGPALASAMRKVVDALPETQRAAAAGAVRRLLVDPDTDLLLRRLTTEEVPDDVVAEVRRAVVAGHRLRIHYRAAADRAPAWRTVDPIGLVTARGQAYLLATRSGQDRTYRLSRVLAAEELDEPATRPDRVDLGRAWQDRGTRFRSGGDQVTVLALVTPERRAGLADTAVAVLSERTEGDGRVRLEATFQDARHAEWALWQPGAHVEVLAPDWLRTTLRDRAAAIAATYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S6</accession>
    <name>A0A7W7T4S6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="30" mass="3200" checksum="C76760F487086DC5" modified="2021-06-02" version="1">MPGDVVFSDEPTRLADTVVPLAGHQSDECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T542</accession>
    <name>A0A7W7T542_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15734" checksum="74243C5F1BD02221" modified="2021-06-02" version="1">MKSKHHGLDWPTGADDPFDPSEDRSGLVYWARGLPSRVVHRRPEAAELYAAIPPGYTTLTVMERLALYRSGDQVRLWAQRETAGGKGMLQPYQLLLPTGEGYLRLGASWPERFALADAERLSSHTGGPVLACRALDHLDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5D0</accession>
    <name>A0A7W7T5D0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="111"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32052" checksum="70829A947117585E" modified="2021-06-02" version="1">MNITLSPTTAAAALLGVGTGLGLLLVVLGWRGTDPQRQRRTRTRAARTVDQHRGLRIALAITVGVVTGLLTGWVVGAVLVGLAAWALPRVLGRDPEHARRVARIEAIATWTEMLRDTLSAAAGLEQAILATAPLAPTAIRGEVGELAAGIENGDRLAPALRRLGERLDDPVGDLVIAALLLAAEQQTRQLADLLGSLADAARGQASMRMRVEAGRARTRTSVRVIVGTTLAFAVALVLLNRNYMGAYDSAAGQIVLLGIGALFAAGFAWLNRIARVVRPDRFLSTADQDPVTSPAPVLVTARQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I0</accession>
    <name>A0A7W7T5I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13491" checksum="23D25D1F8E831E86" modified="2021-06-02" version="1">MHLVIVAFDLKESGVDFPELRAWVRDRAAADYAALPGMRFKAWFSDERKRLWGAVYLVDSADAFDPERLPRLPDGRTGPVGTRPTSITWFDLEAFVAGPDGLDGLDELRAAGLSLRAERTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N6</accession>
    <name>A0A7W7T5N6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030574097" evidence="1">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="41001" checksum="25B96CABC1324416" modified="2021-06-02" version="1">MKKIMTLAATAALLLPGTVAYAADVVWTTVNTDSTGDQDNASVSSVRTGYTAVVWEDDRDSSAPGDPAHSDVWIRLYLDGVSQYEKKLSAGGTGTWRHVQPDVALHEDGSAVVVWSEDPDGNGFYNIALRTVSPSGVVAGSGTANASATGQQYYPAVAADPDSPGFAVTWEDKQDTTNPTVRVAGFASLTSKSYEAQVNGAGGTHQRPDVAVGAAGNAIVVWDEDGDANGAFNVARKILTPAGGVKLAQGVVNATTGGQQRHASVAANFNGDFAVAWETGAQVGVRSFTYLGAASSTVDTVLPGADPQVGIDDQRNAVVTSVETGDVVTQGLNADGTTAGRLPRQTTVRTAADRQDEPALGVDGWGLITVVYTDDNDGNQFDQVYLGSGWVNSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P2</accession>
    <name>A0A7W7T5P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="329" mass="35391" checksum="598443E4F8989E3C" modified="2021-06-02" version="1">MSDERHSVSRRTFLTAAAIGGTAAAVGGLNGVAAQADPSAELPPAYEGDLVAVRGDRLIMVTPMEGELVIPVSHRTSTWFGGQSSLDALRPGQDITIGLDETGFGDRLWADITRIKGVITSVSGNDFEVDPGNGGHPRVLHLPDTARAALRGDYTRWENGYLVDIIGLRRDDSAVAVQAAAPQPGYHVDEMPEFGAAAGYPDLSDAAARQFDGKITWFDDAECKCKSRCRGHNAHASWSRVDKCDFMPARCRRIPVLSCGRKITVHNKCNKKSLSVEVIDCGPDNKRFCDSCTKCGRSPKGRIADLTKPTYVRIGGSLNAGCFTGWAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T637</accession>
    <name>A0A7W7T637_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative dithiol-disulfide oxidoreductase (DUF899 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="25944" checksum="53F00DE31B09D6C9" modified="2021-06-02" version="1">MWTPPVVSVEEWDAAREVLLRKEKEHTRAKDALAAERRRLPWVRVGKEYAFEGPRGRVGLPDLFEGRRQLIVYRHFFEPGVADWPAGGCSGCALFTDNLGHLAHLNARDVTFVLVSAAPQADIARYRAWMGWAGVPWYTTLDDFSADFGVEEYFGLNVFIREGDAVHRTYFTNGRAAEQIGTVWSLLDLTPLGRQEEWEDSPAGYPQEPPYRWWRRHDEYGTAEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D4</accession>
    <name>A0A7W7T6D4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="30649" checksum="0938C149C7A78FBA" modified="2021-06-02" version="1">MSSSTLAPPSTVAAVSVDTAAGVDLAEIAARIREHVVDMCAGPEGGHVGGSMSLVEILATLYFRVMLVDPRFPASPDRDVLLLSKGHGGIALYATLAEAGFFPAERLAGYGTPGSPLMAHPNTAVPGVEMPTGSLGHGLALGIGYALAARLDESDRRTFVIMGDGELQEGSVWESASVAAAQRLDNLVAVVDRNGLQITGGTHEVNDLEPLADRWRAFGWRVFEVDGHDVDALTDALTTEPENGRPTVVLARTVKGKGLPMVENQIRSHYAKLGGRAHRLARAALREGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6G1</accession>
    <name>A0A7W7T6G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045592">
        <property type="entry name" value="DUF6461"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20062">
        <property type="entry name" value="DUF6461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33346" checksum="B81641B8C3FE06C0" modified="2021-06-02" version="1">MTALDDLSWADAHAGHDRFLGEIFCLTFIRDVDGPEALRRIGGLPDTVATRTPEECAALHDFDHGYPDLAAALSLGTWTVLFEPSGFTGSNLVDTLSRGTEAVSVLRHDYASNAFDHAIDGSPVTGFDPDFPVYRHGTDPDRLLPHMRELGFSDEEDGAFDDHPIARALRLAELITGVLPSFEALCGPLPSAHVEPWFSAAPKPPAARPGYDGPLDAVAEARRLAALHGVTDTPELAEALAAAERAERVTITPDSPLGRHVRAWLTESNRAGWSLNDHGGRGRMTDADRDRAHGLGWLARALGAAVDQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L0</accession>
    <name>A0A7W7T6L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15428" checksum="14AD3CD25DCBCEE8" modified="2021-06-02" version="1">MGEGEAALERRRVAFAAETAATVADAEGRVRARSTQTQFSIDIDKAPQLIASLEQAIEKLLKAYRDAEELTKSHPPGKDIYSGFAAMAMRKAAGDEEGGYRWANEKAREALQKTIDNIKAAVAGYRRTEGVAHDAFTGQGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6R6</accession>
    <name>A0A7W7T6R6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">F4559_004970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="14986" checksum="915DBDE17CB70173" modified="2021-06-02" version="1">MRAVVARVTEASVTVAGEVVGSISEPGLLVLLGVHVDDDAAKAPLMARKLHELRVLRDEESCAGTGAPLLVVSQFTLYGETRKGRRPSWTAAARPEHAAPLIDAVVSELRARGARVETGRFGAMMSVRSVNDGPFTVLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T791</accession>
    <name>A0A7W7T791_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008834">
        <property type="term" value="F:di-trans,poly-cis-decaprenylcistransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="273" mass="31515" checksum="B18A7F97FB173C7A" modified="2021-06-02" version="1">MLRRRRAERARRVPRPPEPHPSGATPPDIPAELVPKHVAIVMDGNGRWANQRGLSRIEGHKRGEAVVVEAAKGAIQLGVKWLSLYAFSTENWRRSPEEVRFLMGFSRDVIHHRTDELDELGVRVRWAGRRPRLWRSVIKELEVAEERTRDNDTLNLAMCINYGGRAEIGDAAREIARLAAAGKINPEKVDERTLARHLYQPDMPDVDLFVRPSGEQRISNFLLWQSAYAEMVFQDILWPDFDRQHLWRACEQYARRDRRFGGAIDKPDEESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T792</accession>
    <name>A0A7W7T792_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11202" checksum="FB0C2C05BB28193C" modified="2021-06-02" version="1">MTTDFPPPGSRVAIHLSGHPHDVLREQAEVHLTRYDWHLAGTSTDTTDLLRLVSDGVDLVLLLDHDDVVGVLIALEALRQLRESTGIRPVILTAADFDAPCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7D5</accession>
    <name>A0A7W7T7D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytoene synthase</fullName>
            <ecNumber evidence="3">2.5.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31779" checksum="2889B4E732FB959A" modified="2021-06-02" version="1">MTDLAAAYAHCRESNARHGRTFFLATRLLSPARRPAVHALYGFARLADEIVDSGTSADPAGDLDRLEKRLHDALAGRPTPEPVLLALADTVRRHGLDPGLFGDFLASMRMDLDVVSYPDMAALGRYVRGSAEVVGIWLLPVFGTVVPRTEAEPAAAALGRAFQLTNFLRDVAEDLDRGRVYLPGDVLAAYGVDRERLTRCRRTGRVDERVRRALRHLVAVTYAVYREAEAGICLLAPSARPCVRTAATLYREILDRIVAADCEVFARRVVVPTGRRLAVAVPGLVGALLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V5</accession>
    <name>A0A7W7T7V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041467">
        <property type="entry name" value="Sco4008_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17926">
        <property type="entry name" value="TetR_C_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21341" checksum="105CC93F0B1E25F8" modified="2021-06-02" version="1">MAWNTEETRRRLKEAAVAEFAEHGPAGTRMDRIAGRAGINKERLYNYFGDKNRLFQAVLIEELEKMAADIPLGLEEPGEYAARCFDYHAAHPHLVRLLQWEALEYGRAPVPHEEQRLSHYGKKIAAFEAAQRAGHVTGSIPAADLVFMIISLSAWWFAVPQVARMLTGYPEAADSRRESVIEAARRLAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X2</accession>
    <name>A0A7W7T7X2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31121" checksum="7B9A64959BB1041F" modified="2021-06-02" version="1">MTDVDGSMKAFLTAPECERDAVLAHLVDVETRSHGNGTVFDVGRSPSCPGFSIAVGCTGMGNLRPGTLTERALAMYSPSSTVFVGIAGGLKDHLELGDVVAASKTYAVHGGRGQDDGFRARPQSWEVPHVVEQVARRIKPAHWHGLLSDEGRAPAPRAYLAPIASGEVVLDSRTSPPARQIDRHYDDATAVEMASAGFASAAHANRGALIATVRGISDHADGDKERADRQGSREIAAANAAAYALALTAALHVSEGHATESTRPRPELPGIRNTNVAKGRARMGQQIGVVLDGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T816</accession>
    <name>A0A7W7T816_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">POLIIIAc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="30662" checksum="AE6EC0FA03D7BCB4" modified="2021-06-02" version="1">MGKTGRVVIDLHTHSTESDGTDTPAGLVAAAAAHGLSAVAITDHDTSAGWAQAAAALPPGLRLVRGAELSCASDDGTGRRVTVHLLAYLFDPTSPALAEEQQRLRLERRKRLRRMAERMAADGFPVDPDELMAGLPPDAPAGRPHLAMALIKAGVVASVDEAFARHLNDGRYLVPRTDTPVERAIAMIREAGGVCVLAHPFAASRGPIVSADVVASLAAEGLAGVEVDHPDHDPDTRDRLRGLAKELDLLTTGSSDYHGTNKTVRIGAETTDPDVLDALVERATGVEVLVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T836</accession>
    <name>A0A7W7T836_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-dihydroxybenzoate-AMP ligase</fullName>
            <ecNumber evidence="3">2.7.7.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.58" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008668">
        <property type="term" value="F:(2,3-dihydroxybenzoyl)adenylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="42"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="441"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="533" mass="57204" checksum="90E4A284BEE8040F" modified="2021-06-02" version="1">MSDRLPFPWVPFPWVPFPDEFAARYRELGYWTGETFGDFLAAKAAAFGERVAVVDSEVRWSYRELDERATRIAASFVGLGIAPGDRVVVHLPNVAEFVAVVFGLFRAGALPVFALPSHRFAEISAFCSISGAVGYVIADSSRALADEVVAAVPSVRHVLIAADLAELPAGGPLPEVDASAVAFLQLSGGSTGVPKLIPRTHDDYLYSVRESAAICGLTPETVYLVALPAAHNFPMSSPGILGVLHAGGRVVMASAPSPDVVFPLIERERVTLTGVVPPLALQWMASPARAAHDLSSLKVLQVGGAKFVPEAAARVRPELGCELQQVFGMAEGLVNYTRSDDPEDVVIGSQGRPISPHDEIRVVAEDDVEVAPGEVGELLTRGPYTIRGYYRAVEHNAVAFTADGFYRTGDLVRVLPSGHLVVEGRAKDQINRGGEKIAAEEIENHLLAHPAVHDAAVVAIPDEFLGERTCAFVITTEPVAAPALRAFLRNRGLAAYKIPDRVETVEAFPHTGVGKTSRRDLRRALADTLRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I8</accession>
    <name>A0A7W7T8I8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ribonuclease E</fullName>
            <ecNumber evidence="10">3.1.26.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.12" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="339"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="919" mass="98538" checksum="3EC852BD2B215F9C" modified="2021-06-02" version="1">MSNTDRPAGGAGGGNVTSAHPQLADLPAKLRVHALAKLLGASSKDVVAALADLGETVRSAQSSVTRDLALKVAESLLDWDDIVTGEVDETTEEPALPPREVAALTPLFAPPSAVFLPPTPVPVVAPAATTADVDEEPAAEPVGDEAHADEDAGDEGEGRRRRRRGRRGRGRGKGMGDEADVDESTDEAAEAVGEETVEDEAADEEGEGGGNRRRRRRRRRRGVAEDEATPNEDDPPNTVVHVRDARDDKADSEAAQNEVRSVRGSTRLEAKRQRRRDGREAGRRRAPVLSEAEFLARREAVERTMVVRERGDRTQIGVLEDGVLVEHFVTSSGTGSLVGNVYLGRVQNVLPSMEAAFIDIGRGRNAVLYAGEVDWDAAGLEGKARKIEQALSTGDSVLVQVTKDPVGHKGARLTTQISLPGRFLVYVPGGGATGISRKLPDTERKRLKDILKRVVPEDAGVIIRTASEGIAEEELGRDVTRLQAQWQVIKEKADVPRAQAPQLLYEEPDLLVKVVRDLFTEDFSALIVQGSEAWDVIEAYVRHVAPDLQDRLRRHVGNTEVFAEHRIDEQLLKALDRKVWLPSGGYLVVDRTEAMTVIDVNTGKFTGSGGNLEETVTRNNLEAAEEIVRQLRLRDVGGIIVIDFIDMVLESNRDLVLRRLTECLGRDRTRHQVAEVTSLGLVQMTRKRVGTGLLEAFSSTCEHCRGRGLVVSTEPVAGHAHGGSGQSGQQQQQQQPPQQQQQGGGRKSRRGKGGDNAAPPAEAPVDLPAIVEDEPVETAPVVGPTVTAPDGGASVESGPVSGAAVIGDSSVDEAPDDGRPRRQRRRVARREAGAVSRRESSAPEPAAPAEPVVVERVAEPAASAPVVEPEAPHVSIAPPTQVGPADAAESRNGTTSRTRTRRRAASRPAGPPVNAVTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J5</accession>
    <name>A0A7W7T8J5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19843" checksum="5BC587FB608C9B5F" modified="2021-06-02" version="1">MAEEPVRAVQGVVGVVYGFFLVESPGLDEPPRFAFAARNGFLDVLDDVIGVHATSDWITAADVRIEAWRDPPTVDNSLDGSETSERTVLITDGSVHTRAVPATEPEIPALSLGEPGWYHVRGHRRRSVADARTEDFLLRFWPSDTPAPEDRSAEAEVDEFTRWNREIRAWAREQASSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J9</accession>
    <name>A0A7W7T8J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8754" checksum="61470AFDB0F24D19" modified="2021-06-02" version="1">MQGDLDELNGSEEHAKKIEQGATAIRSIVSSRMQMAKVKKSLKPLGASWKTQGRTRRFAAENYYPNIESTCSFYMPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W6</accession>
    <name>A0A7W7T8W6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="10" type="ORF">F4559_005860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="8">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17822" checksum="99AAEC62953B560A" modified="2021-06-02" version="1">MSDTEVTWLTQEAYDRLKAELDEMIENRPVIAAEINARREEGDLRENGGYHAAREEQGKQEARIRQLQELLRVAKVGEAPTTSGVAAPGMVLTVRYDGDDETEEFLLATREEGAHGALEVYSPSSPLGKALLGAKDGETRQYELPNGSTMKVTLIKSVPYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T924</accession>
    <name>A0A7W7T924_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine kinase-like BadF-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="8"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="33392" checksum="14E0F2CC0A090FB6" modified="2021-06-02" version="1">MTERVLAIDGGNSKTAVALVDVAGRVLAQVRGPGASPQNVGLARSREVFDSLVRETARRAGLSPDERIATHTAAYLAGADLPKEEEDLTAALAGLWSETIVVGNDTFALLRAGTSDGVGVAVVCGAGINCVGVAADGRTHRFPALGRISGDWGGGSHLGAEALWLAVRAEDGRGEPTALVAALKAHYGVRSIADAVESLHFGKVEFDPHPLCPLLFSVARDGDAVARRVVDRLVEEITLLAGVSLRRLGLLGEAVDVVLGGGVVTGTDVARFVASSLSATAPLARVRVVDVPPVVGAALLGLDALNADPSAEARLRAAYEPLSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R4</accession>
    <name>A0A7W7T9R4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.288</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.288" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045699">
        <property type="entry name" value="GlfT2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040492">
        <property type="entry name" value="GlfT2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19320">
        <property type="entry name" value="GlfT2_domain3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17994">
        <property type="entry name" value="Glft2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glft2_N" evidence="2">
        <location>
            <begin position="32"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="GlfT2_domain3" evidence="3">
        <location>
            <begin position="449"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="647" mass="72605" checksum="20B0E6CF19E19078" modified="2021-06-02" version="1">MTEQSPVDPKHQGTADSASARDGAGLDPKKVLQRVILPRDEDPLDVRPLYLDEPENVHSHVSSRRSVTVPASAKVSFASYFNAFPASYWKRWTVVDEVVLRLRVRGAGRLDVYRSKPNGDIVHLDGRPVRGDKSAWASVEFRVSLKPFEDGGWIWFDVFTDESTLEIGEAAWTTDLDLPTQQVAIGMTTMRPVDAVIALRALGEDSAVLDVVQKVFVADQGAVKVRDTEGYAEAVRLLGDKLEVIEQDNLGGSGGFTRGLYEAIEHTDVDQIMLMDDDIRLEPDAVLRSNAFARACAQPVIVGSHMLNLQARARLHSMGEVVDLGTCYWRAAPGALTDHDFAAESLRETEELHLRINSTYNGWWMCLFPREVVQRTGYPLPLFIKWDDAEYSLRALENGYPTVSLPGSAVWHMPWTDKNDATDWQAYFHTRNRLVLAALHSPYDVRSTLLKQGLKLSLRHLLSMEYSTVAVQQKAIEDFLAGPTKLFDSLRTALPEIQALRKQYTDAQVLPSAREFPPPTFDMVRAESMLKPPTNPATIAAEAAKALVHNLREPDSSTTERPQINVPATNARWFLLGNLDSATVSNADGSGVAFRKRDPKEFRALMKRAVRNYRRLGQEWPRLKQVYRDALPELTSVESWRKVFEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T5</accession>
    <name>A0A7W7T9T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043746">
        <property type="entry name" value="DUF5691"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18944">
        <property type="entry name" value="DUF5691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="51838" checksum="91F3481C67B16C1E" modified="2021-06-02" version="1">MSRDAEWDETVQTLLVGAHRSGVDAAELLDRCAALGLAAHGAPLPPVAEGGFLEQAPEATEALVPPAARDVLAQITASDDQVLLTEWCGMARGVGLVAHHRELPVLLDLGTSHTGLRQAVTAVLGTRGRWLASVRTRWNWAVAAVEAVDLDNAMDLPGPARQAALRRARTLDPDGTREFLAAQYDRQPRAVDRQAVVNALEAGLSHDDEALLERALDDLAIGVHDEALRLLRALPDSLLARRAADRLHRGLWLTAEGFDVRSDELWTVVEPDPEEARDLLRDGSESGVTGRIRGASAAVPPGYWTRRLGSDDVDAARELERSPWAAALLRGVAQRLNLAVDARPWAVAATRSLTGMEQLEMLATLPTDLAARTVVEVSRQWNYDLLDHACSQLPAPWSAEATAALLGRYADMRDPRWRAGRPPAVLLTRGDAEVLGANWHVITERWPTHTSELDVLRLRMQLRDAFAPHRKDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBA8</accession>
    <name>A0A7W7TBA8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="10" type="ORF">F4559_006806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="616" mass="65790" checksum="D3D9393F694A4F6E" modified="2021-06-02" version="1">MARAVGIDLGTTNSVVAVLEGGEPTVIANSEGSRTTPSIVAFAKNGEVLTGQPAKNQAVTNVDRTIRSVKRHVGTEWTTEVDDKKYTPQEISARVLMKLKRDAEAYLGEPVTDAVITVPAYFEDAQRQATKEAGQIAGLNVLRIVNEPTSAALAYGLDKGETEQTILVFDLGGGTFDVSLLELGDGVVEVRATSGDNHLGGDDWDQRVVDWLVDRFKQSNGIDLTKDKMALQRIREAAEKAKIELSSSSTATINLPYITVDADKNPLFLDETLSRAEFQRITNDLLERTRAPFNNVIKDAGISVGAIDHVVLVGGSTRMPAVAELVKELTGGREPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKKSETFTTADDNQPSVQIQVFQGERDFAADNKKLGMFELTGLPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGKEQSMTISGGSALPKEDIERMVRDAEAHAEEDKRRRDEAEVRNQAETLVYQTEKVVKENDEKIPAEVKEKVNAALAETTEALKGTDIAAVRSAVEKLATESQAIGQSLYANTGAPTDAAAGGAAGAAAGDAQADDVVDAEIVDEDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT67</accession>
    <name>A0A7W7WT67_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ORF">F4559_000270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14486" checksum="3A34A1A319360DAB" modified="2021-06-02" version="1">MPPKSRQGAGVKKVRRKEKKNVSHGQAHIKSTFNNTIVSITDPLGNVISWASAGHVGFKGSRKSTPFAAQMAAENAARKAAEHGMRKVDVFVKGPGSGRETAIRSLQAAGLEVGTIQDVTPQPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTH4</accession>
    <name>A0A7W7WTH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="21487" checksum="FFDA4BF56873EDC9" modified="2021-06-02" version="1">MVLTLLFPIRCAGCGAEGVRSCARCLGAFGPPRRVPFPGSPVFTLADYAGAARELVLALKERGRRDLAAVFGALIAAALPVLPGMFPDESGNRWLVPAPSRRAAIRRRGGSHLVGVARASGARVAPALAYARGVRDSVGLDASARRANLGGRVRLVPAGLPPPGTSVVLLDDVVTTGATAAACTSMLLSAGLRVSAVMTLTAVRRGDTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN2</accession>
    <name>A0A7W7WTN2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide isomerase/thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="14648" checksum="29F371819DE6912B" modified="2021-06-02" version="1">MSTTGLWALLGVVLVVAAIGVVKKVRDGRVRAARKTVDLPEPVRALLDADAAVTLVQLSTTFCAPCRHTRVLLADLAAKTPGLRHAELDVADRPEVATTLGVLRTPTTIAFDASGAELLRVGGVPRREALAEALRTHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP0</accession>
    <name>A0A7W7WTP0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="812"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="947" mass="102048" checksum="F504AC1C291D40EF" modified="2021-06-02" version="1">MTRFSVLGPLEVWHDGAPVPVPAGRARVLLATLLLRAGRSVPVDDLVARLWDGDVPNPHRVRATLHMVVTRLRQALGPANVVRTTTNGYRVDILPGDLDLHRFRDLSERGRYADALALWRGTPLSDVRSDLLHAEDVAPLLEERLLVLERRVEADLDAGRAGGLVAELRSLTRENPLRERFWGQLVLALYRSDQQAEALAAYQTVRELLADELGVDPSEYLRGVHQSVLNGDAVPPAWPVLCQLPPDNVDFVGRADLEAEATELLACDRGVPVVAITGAPGTGKSALTVRIAHETRARFPDGQLFVRLDGAGGSPRDPAEVLAELLAAVGVDSAKIPDRIDARAAAFRARIADRAVLVVLDDAAGLDQVRPLLPGTPGCAVLISSRNQLTGLQGVRGVRIRPLAFEPGLDLLSRMVGAQRIAEDRVAAAAIVEACGGLPLALRIVGARLAARRSLPLAKMASRLADERRRLDELSISDLEVRAGLALSYAALSQDAALAFRRLGLLGAADIAAWVVKTLAGLDDPDPALEQLVDANLIEEVGRDATGEPRYRLHDLLAVYAAELARADGDEVCDDALRAYADELLGLLDHVVKSTWLGTDELPLLPVPPPALLSQIEVDQLVGDPAEWYAREASLALRAVELCATRGWAPLAHHILDRLLVDDRAHLAVDSAIRICEVVVDAARRDGLDHVYWRAELHYLQETAKVAIDGSLLGRYIDCVRALHDLDRPAEEAIALASLVHFRRLHTGEPDVASAEAAVEAATRAGVDSVLMSTLREFASMLAASGRYAESLPHFARLVEVSARSGDPAGEALVQYRLGTYAMAEGDMDRAVEAAQRSVELMDRTDDVRGQAYVGSLLGRVLIAVGRAPEALDLLVSAHREFTAIGEVLGIANAVAGLAEVYLALDDPESALEVIEPFLRDHRDVGLVDVDERVAKAYQAATGALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTS4</accession>
    <name>A0A7W7WTS4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7626" checksum="BF73EC119D649F01" modified="2021-06-02" version="1">MFFKWPFGRGNKITTCACVPEWPGLVAEQAGHHVTGVPSPEGSSPMVMMLGLVAHCTGCGARYPHGWRVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU00</accession>
    <name>A0A7W7WU00_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="8869" checksum="FFFD97B3637C260C" modified="2021-06-02" version="1">MTLSTARTELDPQLRPLDTPADAVGLTAATTAAGALSALVTTAVTTDLPWWAVGLSGLAGASAALVLLAVSAALIGAAGTVLARARRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU25</accession>
    <name>A0A7W7WU25_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="40949" checksum="B2A5E71260166674" modified="2021-06-02" version="1">MLAPVTIIGSVLVAVLLVTLLHRAIQRIGRRSDLFATLAAHAHKPALTVAVLAAVRTSLAWTVEASWLPAVQHAIGIALILAGAWLLAALLVVLEDAMLSRIRVDVSDNRHARRVHTQVTLVRRVTVVIVGVLAAAAVLMTFPAVRVVGTSLLASAGVIGAIAALAAQSLLGNVFAGIQIAFSDALRLDDVLVVEDRWGRVEDITLTYVVVQLWDDRRLILPTSYFLTKPFENWTRTQSALLGTVELDVDWTVPVEDLRQELRRALEGNDLWDGRVCVVQVTGAVESFVRVRALVSAVDAGRLWDLRCLVREHLVNWLRDHHAGALPQVRVRELPRTANREAPSLPEQGSDNRVFGESLDGQERVQAFSGPDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU40</accession>
    <name>A0A7W7WU40_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="72" mass="7725" checksum="C7ED90157E8E674F" modified="2021-06-02" version="1">MADTRLLRTCIGCAQTDDHPRHVVWQPGDVEVTWHMDCHVIATGCPVCEGQLAGADGLTGDALRAHLTTKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU57</accession>
    <name>A0A7W7WU57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Imidazolonepropionase-like amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="44"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="38246" checksum="F5CB1D4C80D15858" modified="2021-06-02" version="1">MTGLHLRGVVLPDGHETDLWVVNGRIRTERVFGATTVVDRGYFVPGLVDAHCHVGLGAEGAVPLPEAVEQARIDRDTGTLLIRDCGSPLDTRPLQERLDLPRIVRAGRHIARPKRYLRYLGVEVERESDLPTAVAEQIQYGDGWIKLVGDWIDRTTGDLEPLWSDDVLRDAIKVAHDAGARVTAHVFGEAALPGLLAAGIDCVEHGTGLTDDTIDLMASAGTALVPTLINIENFPGIASDAGKYPAYQQHMRDLYSRSKRTIGAAIEAGVPVYAGTDAGGGIAHGRIVDEIEALHGVGMTGHQALAAASWAARAWLGHPGLVEGAAADIVVYDDDPRTALTTLRHPRLVMLRGRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUI8</accession>
    <name>A0A7W7WUI8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="29778" checksum="65CC5A3C4D79D2FF" modified="2021-06-02" version="1">MSRTIRAAGAVVWRDGLVAVVHRPRYDDWSLPKGKLDPGETLPGCAVREVAEETGFSVVLDRFLVQAAYTAFGRPKTVDYYAATVVGGSFTPNEEVDELRWLPVSEAADLVTRPDDRQVLSAFSPPAGVVLLVRHAKAGKPAEWTGDDDLRPLTPAGREQVAGLRSLLRLWAPARVFSAPPLRCTDTVRALAADIGTSLVEEPLLSENGYWESPTAGMARLREIAAAGGTAVVCSQGDVIPDVIGRLHPGIATPCKKGSTWVLPVSPSTSDPHYLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUZ5</accession>
    <name>A0A7W7WUZ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030584524" evidence="2">
        <location>
            <begin position="30"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="506" mass="52954" checksum="B5CE7774FF48ABA4" modified="2021-06-02" version="1">MPSSYRGAVRLLGFLVVVGVVAGCSPGVAEPGPDSGKAGPTGTSASPPAVATPEPASVVLTTDRDRRSGIVADGGGDSPYNYGPTVLLENGRYRMWWCSQLGYAAPAGDDLLYAESTSPDGPFSAPGGGSAIPVLSGSTSGFDGKHTCDPSVIKVGPTYYLYYTGAAGEHAHGNAIGVATSTDGLTWARAADGKPIVSPSYDTTRENTYGAGQPSVLYLDGWFYLMFTDTTGKAAGWNGAGQFVLRSKVATFLTGVEALGPNGFHKVEDAHSTRERSVVDAFSADLSFVPALDAFVIAHETEQGTTLTFWNRDFTAEPYGRVHVAGPWREGPGLVRTPHGLVPVSDEDPCGRIAFDVVRATVDGRAGAPTDLTHFGLDVAEAPGCATTRAAAALEGFAVPSPENTVDLVLKGQVVRIERRSVTDRLATKVLDHRPAIVDKLPVKARIPAGAKAVRSPDGTVGLVLGDDKKVWLVDAEEIAALNGSTVTAVSKQTWDGYQPVRDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV13</accession>
    <name>A0A7W7WV13_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031172233" evidence="1">
        <location>
            <begin position="31"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="25279" checksum="8CDC98FFEFC55B10" modified="2021-06-02" version="1">MKRSRDLLLVGCAVLALGGCGTVAGKPIPAALPTTATTTSAVVEASNLADREKAVRATFDDYKRAALAKDGEGAAGRVSWSTAGYYGRAIPLALTAHAGELRAAGPTFTMIAYALRAEFDAERLHTITSHSVVEVAVEKELTGIYDLAAIELTDVGLDGDRATAQFLFRGEPGGLTLHFVVEGVTWRFDLMSLIVQADGIVEAQARERNQSLDEYVDTVIGGLYGVDRLPGLKRPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC7</accession>
    <name>A0A7W7WVC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein (TIGR00698 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="37808" checksum="2B3335C43034AFA0" modified="2021-06-02" version="1">MAAPEASTPAAEESRSPVLFAVLGVLAVLVLSWVARWLSTGVPKWTKGTGLEGIGAAVEFPIYAIALGLLGNAVLSVTGLRDRLSGGFRTEFFIKTGLVLLGASINLAVIVRAAGPAIAQSIVLISVVFGFSWWLGGKLGLDEKLRALLSAAVAICGVSAAIAAAGAVQARREQLAYSASLVIVFALPSIFVLPLAATWLGLTPEVAGAWIGGNIDTTAAVTAAGSLAGEESLKYATIVKVTQNALLGVVAVALTAYFALKVEKRSTTVSAGRQLWQRFPKFVLGFLATSIVATIYSEQVSAATSKAAIGVVNDLRTWFLILAFVSIGLEFRAGALKQAGWRPVGVFAAATAVNLVAALGLALLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE1</accession>
    <name>A0A7W7WVE1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YaaN involved in tellurite resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="376" mass="40299" checksum="E1F0BA45FFA0C3B8" modified="2021-06-02" version="1">MDDFALAPPEPVAAVPVDRAAGLVAIADEAATTRRAEEFAERLGALDVRSPEFGAAVDELLTVGEADMRAAAGVAAVMLDRVVETGTAPHAPVTTSLADLRRTVAELDPDRLPLTGRKLLGMFPAANAAKKALDRYRAAGAPVDALVLDLRARQDRLRRDNAVIKGERVRLWRTLTGLSEAVAFAAAVDAAVDRQAEIFDLADPDRARALRADAQYPIRQRRQDLLTQLAVTAQGYLALDLVRRTNDELIRGVDRAVTTTVAALRIALLVGGALANQRDVLDEVAALQATTDGLIRANTDLLGLQAAEVRAASRDPAVAVDTLRTSFDRIYAAIDAVDGFRAEAVRSMGVTVDALSDEVRRAQDHLRRSHRTEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK4</accession>
    <name>A0A7W7WVK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18604" checksum="A517E79BA854E993" modified="2021-06-02" version="1">MAKGRKRRKGETFETEVRRRFGPLAEQFGLIEVPADNRFVGASEVDYSNGRLRYDWSCDGWEDYMFILVILELDGFRHVVGLKELVAATRSAGDQPLLDNCRSWLVLQRAVESHTQWVERLHPRLTAPDAADFVVAAGGSRRSLSDPGPGLDLDWFRKMPPADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK5</accession>
    <name>A0A7W7WVK5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isocitrate/isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="2">
        <location>
            <begin position="4"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36924" checksum="35E99DB546ABC323" modified="2021-06-02" version="1">MGAVVGLAVGRGTGAELADVFERVLGVLATGVAVERSPRVYDSYFSLRDNDSGTPAMRERTLADAGHYERFCRDLAARGARAVFRTAINAQSLYLVRQRLRAVKVDEITAGLLVVRDQAQGFYTGDNEHGPGIITRTTVFRREITREVLSYAVERARELWPEGPAEIVLAYKFHLLDGEFDRWVREAAADAGVAVRLCQPDTVNRDLLERGPVPRTVIVAGNEWGDIMHVLLLDRYGSRRQEESCTENVYLHPDVAGLTEFQTVHGSADDIAGRGLVNPTATVRAAAAVARQVGCAGAVVAVERALAAVADEGIATPDRGGRHTTTEVVDALIASPDLLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM7</accession>
    <name>A0A7W7WVM7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lycopene beta-cyclase</fullName>
            <ecNumber evidence="1">5.5.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.19" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="38296" checksum="8F6C07A0F8532F7C" modified="2021-06-02" version="1">MDVLVVGGGPAGRALARACVGRGLDTALVDPAPARPWRATYAAWSDELPADARTRSESRAVVVATRRHDLDRGYAVLDDRWLRDLDGVRVLTGRVVGRTPTTACLADGSVLGAGAVVYAGGTRGHVHQTAIGVVVGARAARPFVADGEALVMDWRRPPDAGTPDPTFLYAVPLGDDRVLLEETSLARRPGLPAAELRRRLRSRLAAHRIAVPDGEERVRFPLDVPPGDGFGATAGFVHPATGYSVAASLRLAPVAADALVSGVPVERAMWPYRAKAVHALHRFGLDAVLALRPHQVPEFFDEFFDLPATFQRSYLSDRTDLRGTVAAMSGLFRSAKWSLRARLAFPVRSAKVVRTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS3</accession>
    <name>A0A7W7WVS3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6885" checksum="E01076A15A2BFC91" modified="2021-06-02" version="1">MIFVDLAERPHATLHPAALDAALHALALGSDSAARVPFSWRGARLHAPGSHPGGRGCRRPGPAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW9</accession>
    <name>A0A7W7WVW9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="16906" checksum="D5A07B3C294AB37F" modified="2021-06-02" version="1">MSVDFAWTPRPADWWVAQRTAVPLFRWAPLFALVLCATSLVVLWLDMLVPAVFGLVLAFVIFAAVPIGVSANFRGHPLADRPVTGSADAHSMRMVVGDAARTELGWVEVPGWTESSRVFVVRAPGDGTYAIPHRAFADAQAVAAFRALLVEHVGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVZ4</accession>
    <name>A0A7W7WVZ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate/tyrosine decarboxylase-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="50869" checksum="FA32B73105E283D2" modified="2021-06-02" version="1">MGDPLHAADDAVEALGMVDRAARPYLDALPHLPVRDATHAHLLDDLDGPLPEDGDGTLTAVAELLRIGTKAATHSSGPRFFHFVVGGATPAAQAADWITSLLDQPAGLWLTSPLATRAETVVLRWLKELFGLPASHGGVLTPSATFANLTGLACARFDWGRKHGVDVTADGLAGLPRMPVFSSGYVHASSRKALQLLGVGRDHVRTLSRDDAGRIDLEALDRELGTSGPAVVIANAGEVNAGDFDPVDAIADVVARHDAWLHVDGAFGLFAALSPRTAHLTAGVDRADSVAADGHKWLNVPYESGFAFVREAGLLGRAFGGWNAPYLPEPDDEFVNYNNLGPESSRRARAFPIWATLRAYGRAGHRAMVERHQDLARRLGDAVEADPDLESLAPVTVFVVCFRYAPAGLSEPELDDLNRRLGAELLDDGRVYAGTTVYRGRVALRPAIVNWRTTADNIDLLVRTVKEIGARLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVZ8</accession>
    <name>A0A7W7WVZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="33453" checksum="4833829EDC5FC607" modified="2021-06-02" version="1">MSQDEAPYRRVAAEIRDRIATGALRPGDRVPSTRAITREWNVAMATATKVLTLLRQEGLVESSSAGTVVASTAGPRDRPRPAAEDLTRTRVVRAAVEIADAEGLAALSMRGIAARLGVAPMSIYRHVAGKDDLVLLMADAVLSELRLPAGPDAPQGWRPRLELAARMLWRVHRAHPWLAHLGPLTRPTLIPSLLDYSEWWFATLSGRGLDPALVLDLNVVLYSHIQGLAVQLEREAQAVDDTGVSGEQWMHEQESELAARLADGGHPAFASAMAWFGRTGYDLDFDALFERALTALLDHLAGLLGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW57</accession>
    <name>A0A7W7WW57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021295">
        <property type="entry name" value="DUF2867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11066">
        <property type="entry name" value="DUF2867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21142" checksum="ADE5E337367B40A5" modified="2021-06-02" version="1">MRLPDTAHTRQPWRIHEIAPDFHLEDVWALPTPGGVDDFPRLVRLTANRDAADTPSRAARALVVVRRVLGSWFGWDAPDSGIGSRVGTLRDRLPADLASAPPGPEFPHRPFTSVYLTETEWAAEIANRTVHAVVHLAWVPDGTGGYRGQMAVLVKPNGALGRAYMKAIAPFRYLVVYPPLIRHFGQAWRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW75</accession>
    <name>A0A7W7WW75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025355">
        <property type="entry name" value="DUF4259"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14078">
        <property type="entry name" value="DUF4259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14236" checksum="CBEF1D17C05B9E90" modified="2021-06-02" version="1">MGAFDNDFALDFLDDVRGSAPGNIPDVLSNALSAAAEVGAEDCLDRAEGEAAVAAATLVVARALPDGTLVPGGGILNVMPMPSASLSRLAVVALRRVLDENSEVCQLWREVDLGEQWRSGVEALLAKAVRISGFDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH0</accession>
    <name>A0A7W7WWH0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CDGSH-type Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="4">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10642" checksum="FB8041CC11FC4CC6" modified="2021-06-02" version="1">MGTRRVLTPHHDARGGVLMADRDPDRRRPAPATVVVVQDGPIIIRGDYDLCAQTGEPIDPQRRTIALCRCGRSLLKPFCDGSHVWAKNTVEGQQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWW6</accession>
    <name>A0A7W7WWW6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021246">
        <property type="entry name" value="DUF2797"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10977">
        <property type="entry name" value="DUF2797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="33295" checksum="E1F0978BFE72353F" modified="2021-06-02" version="1">MPAARPTDGEYVCHGITWATGDPRLLLAPLPDGPLVYAEIMNQRLGFAVGTGRWCTGRYQFADTVRVEALACPDRAPTEQGDQCARCLCQDEFRFAHQFHQDGSVPAALRQYMDQPHWLYLATFADGATKVGTAAEPRKQSRLDEQGALIATYLTKSPDGRAVRHLEDAITRGLQVPQTIRASTKLKALANLTDLSTASATHDRHVSHAADALAAMNTPVVLETWTPPAEGDRLRVANGVRMLYPHDLRDGEHGFTVVSCVGTQVLAALDGDDEVDYVLDLGTLKGRRITLGPFTSPAAAFQNSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY2</accession>
    <name>A0A7W7WWY2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="31851" checksum="4A639700CD32CBB0" modified="2021-06-02" version="1">MTNSLDLEHLRTLVAIAECGGFGKAAAVRHISQPALSQHVRLLERGLKRKLFERDGRNMRFTPEGERVLVEARRIIEVHDASLRRLEAKPDRTVVIGSTEHSAGQILPEMIRAMQAAFPDCSTRFEIGRSTQLVESARRGTVDFAFVLDPTGQGAGHLVGRLPLVWYAARGWSPPAAGRTWPLIAFEEPCGLRERALSVLTGEGHDVEVTAQSTTLEGVLAGVRAGLGVALLPSAGGRPTGLSACGDLPDAGTTHLRMVTRRGLAAEVERTALAAGVEFFAQRPHLQLVPAATAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX15</accession>
    <name>A0A7W7WX15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6649" checksum="EC2D853920B81C4C" modified="2021-06-02" version="1">MTADRCPRPDCGGTVEDTGFCDTCFRRPDGTPRPVAPPPAGRRTTGGLRSLPVFEFPTRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX85</accession>
    <name>A0A7W7WX85_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine nucleosidase</fullName>
            <ecNumber evidence="4">3.2.2.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="2"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="32798" checksum="EACBC4662AA05884" modified="2021-06-02" version="1">MIDTDPGIDDALAILYLATRPEVEIVAIGTVHGNTTAHQAALNILRVLDIADHPDVPVAVGAARPLAQPLHTAEFVHGPDGLGGHPGPPSTRDLAGTSAAEQLVRLARDHPGGLTLLALGPLTNLALALLLEPELPHLVGRVVAMGGALAVPGNITPYAEANLWHDPEAADLVLAAGFDLTLVPLDVTESVRADRAWYDALAHAGTRRARFATAILRHYGTFYETVLGRPEYTLHDPLAAVLTLDPALAEHRMLPVAVELTGTHTRGRLVADLRLLAEDADLPGVITDRAPVAVATAVDAPIVLDRLLSALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA9</accession>
    <name>A0A7W7WXA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025498">
        <property type="entry name" value="DUF4389"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14333">
        <property type="entry name" value="DUF4389"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="48458" checksum="4957FF33994ECB5E" modified="2021-06-02" version="1">MTTYPVRVHGRFDPALNRWLWLVKWLPAIPHYVVLAVLWTAFGVVGLCAFVSILVTGRYPRPLFDFALGVLRWTWRVAYYSFGALATDRYPPFSLGEEPDYPATLDVAYPERLSRGLVLVKWLLAIPHLVVVTIFLGGGGYLAFRAGEWAFSPAGGLVGLLVLIAGVVLLFTGRYPRGVFDFVLGMDRWALRVAAYVGLMTDAYPPFRFDPGGDEPGAAALDAPPPPASSSGPPSRVVPAVIGVLLLLLGTGSASAGALGLWAEQARRDATGAVAAPALTVHTSGYAVELGTAELRWTEAGQAVGEDWLGTVGLRVDPGTFVGIGPAADVTRYLAGVERDRVTGFGDRTAYRHSTGVAPTTPPHAQPFWAATGVGSLTWTPRPGDWTAVVMNADGSRVVDTPVVATATLPALAPLSWTAFGGGVLLLLLGGGLVLFAATRPTRPAAPVRTTIGDEDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF4</accession>
    <name>A0A7W7WXF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-associated toxin RatA of RatAB toxin-antitoxin module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16931" checksum="77FC52C7F348C844" modified="2021-06-02" version="1">MTTRTLRAEVPATAAEVVAFLERDTDFPTYAPDLVSVSGRGEWVLAFRGGTATWTQAVRRSADHPDRLEFLQIEGDFQRLMGSWTATDLPEGGSEVEYRVDYGTSVPHLAGAIDSAVGRVLVRTAHAIVTAIGGRARVTEGGEYVTDPLERLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP6</accession>
    <name>A0A7W7WXP6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="775" mass="84384" checksum="506B1DC77D09C403" modified="2021-06-02" version="1">MNGIGKKAPEATDIGGELQRLRKAAGMSRRDLADRTHYSPSHIANVENGIKSPSPEFARACDAALGADDVLTALVDVGRKPARNPTTRRVPAQLPRPVPLMGRDGLLEELDRVLARSRSAGRAPVIALDGEGGVGKTACAVAWADRVRHDYPDGILFVDLAGHGTSGRVDPFAVLEGLLRDLGVDAAEVPTTPDRRTAMLRTVLADTRTLLVVDNALDDDQVRPLLPGSADSLVVVTSRRRLSSLAVHEDAVCVHVDALDEDAAAGLLREVVGRERVDTEPEATARILRMCAYLPLTVRIAGNHAIVHPHGSLADLADEMSAIDHRLDVLSGEAGNIRAVFSWSYAGLDAQDARLFRLLGLHSGDAFSAEAAAALAGIELSHAVRALDRLVALRLLEEVGKHRYRQHDLLKAFAVERVHSEEDSAQALAATTRMVDWYLHTSRAANQVLAPHRRDPELGPPVAGVPSPPEGWTYTQALQWCERELPNIVAVTDDAHRAGLWDRAWKLPVCQWNFFYLRKHWSAWSASHESGLAAARAGGDVFGQAWVLNNLSHAYRERGHREQAEVMSHEALRMRVEIGDVTGQAWSTVALAFLDLEQRRPDAAITRFTDALTLFRRVDDWYSEAIALGGLGEAARLAGHPEQALGYLSDALTVMDAAADRFGQGFTLTRIGSTLHLLGRHDEAARRFDQGLRARRESGDRWGEADTHIAFGDALLAEGAHGRAADQWRIALAILDELDDPRADAVRRRLDPTTPSPRPSPPDTAPIGQARSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXV1</accession>
    <name>A0A7W7WXV1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="22360" checksum="CF8770ED0AEF137E" modified="2021-06-02" version="1">MSDVRVLVVDDQRLIRESIAALLDLQDGVTVVGTAGDGRAAIEAVEVLAPDVVLMDVRMPVLDGLDASTLLRGKAHVVMLTTFDDEDYVVRALRAGAVGYLLKDRPAAELAAAVRLAASGVAQFDPAAVARLAEALDGNRPPVVGDHDLTGREVDVLRLVAAGCTNREVGRRLHLSEGTVKNHVSRILTRLSLRDRTQAALYARDRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY40</accession>
    <name>A0A7W7WY40_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar lactone lactonase YvrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGL" evidence="1">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="25674" checksum="61C28EF7F6790566" modified="2021-06-02" version="1">MSIEVAVPAGAGRSGCPVWDATSATLLWVRGHEVHRYSPGGADAVLELPQPVGAALPRRRGLVLNLRDGVALIDEDGAKTWLVYWAREGYAAVGAGVDPAGRLLAGTARGDDGWLARVLPNGDAKVLVGGVGVTGFDWDPGYSRLFVGSSRGVDVYGYDVSSGDVGERRSFLEVGVTGVAVEAGFVWVGVGSSVRRYTSGGVLDLVVEVPGEVGGCQFGGRDLTDLYVTAGGGVFVVPGAGVGRVGGVFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA8</accession>
    <name>A0A7W7WYA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="127"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="40062" checksum="EA5D5D2503F1E8B7" modified="2021-06-02" version="1">MTEPTGATTGRYLVLLADGSGAAGARELHRVAGLTATSTADSATSEELAAADGLILHDLGVAVVDAEPEQARRLSLAAEGAGPISVVEPERVVQAYSTTAEEALAVDETVHTWGLQAVGATLSAATGAGVRIAVLDTGFTTDHPDFAGRTVFTNSFITGETVDDAHGHGTHCIGTAAGPRKAPSGGPGYGVAHQADIYAGKVLSNAGFGSDGGILAGIAWAVANDCAVVSMSLGAPVEPGTPASPVFEEVARRALGRGTLIVAAAGNESRRPNSVRPVGHPANCPSILAVGAVDVNRAIAFFSCGTKDTIGQVDLVAPGVDVYSSWNKDWEQLGRHRRIQGTSMATPHVAGVAALVAEKHQARGWELWARLAQTGRRLELPSVDVGGGLVQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM2</accession>
    <name>A0A7W7WYM2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="603" mass="59178" checksum="CC22875618A2567A" modified="2021-06-02" version="1">MAEQQATTQGRDPSHLISDVQGTVSAVERGDWVSAGLGMANTAMGIVGLAANPLSGFLSAGFSWAINHVSFLREPFDALLGSPESINKMSGAWLSASKQIEQIVADYRRTSVEETKGWRGKSADGYRAAAKKHASGLETLSKAAKGISDAAKGAGQLVATVRKTIMDLISQAVSDMVMKIIQWLAASFLTFGAAIAAAISDIVQMACNYAKKLADFLQKLGDSLKKLIDLIKSVGQIAQTAKQILQAITAMTHSNKGAGGANTRPSSGGLGLTDEQLRQMDQNARDRYVNGGVTNPSGGGGGGQGPSGPVVNRPPVLNGGGGSPTDPSGYPGGGWGPGNPSGPVVSRPPVVGTPDDRRYYPGIVPNPTNPTGPVVGRPPVVGNPGSGGSGGGTGGPGTGGGHWEPGKWVPDGGSSGGGGGGRVTPPYIPPGGSYNPNDPFPNYPSDRSGYTHTTNSSGSTPTIPPVRPYTAPDLTHTSGGGGGGGGGIPGGFGGGGGGGVPGGFGGGGGGAAGGTPTLQAGGASGVLPAGAGGGAPGAMGGAPGAAGAGRAGGGAGGMGMGMMPPMAGGGGQGDGKDHQRKVRIEGEPLIEDAPKAAKPIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ09</accession>
    <name>A0A7W7WZ09_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="35234" checksum="CB30B2DC3D682B47" modified="2021-06-02" version="1">MTDTVEASRAPLTHVPLSTTPLPHLDTSIQPWPGDHLVVGGHLVHVRRTPGPDGATAVYVHGLGGSATNWTDLAAQLAGHVRGHAPDLPGFGRSEPVDGYDFSLAAHARVVASFVAGLDAGPVHLLGNSMGGAISMIVAATRPDLVRTLTLISPAVPDLRPSLRRVSDPRLPFAMLPVVGPRLRARLALVTPAERTRQMLRLCFAEPDIVPAHRIAQSDAEYAERSTQPWAGHALGRSTVELIRAWLAPRRRSLWVLAPRITAPTLVVWGTEDRLVSVRKAPRVARLLPRARLLVLPRTGHVAQMERPVTVARAVLGMWEAVAAGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZD8</accession>
    <name>A0A7W7WZD8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin_N" evidence="3">
        <location>
            <begin position="40"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="605" mass="65286" checksum="7FE5A47B2E4B73E0" modified="2021-06-02" version="1">MSTLPQTVRQTREKLTALVRSLDPEAAAFVEGTRGGAASVVVVGETNRGKSSLVNALLATPGLSPVDAEVATATYLVFRHAPEWSARACYAGSMSSVSFDREQLVNWVSAAHELPEGMLPPRYVEVDAPVPLLERLSLVDTPGVGGLDSVHGELAAEAAASATALLFVVDASAPFTRGELDFLRTVGERVETVVFALTKVDQFRGWRQVLEADQALLAEHAPRFADAVFWPVSSRLFELSFKAPNPDAAGMLRERSGIGDLQGALQELVVGRAAMLGEANGLRALATVLDELLARSEADKRALSSGEEEAEALRSRRDELNAQRRSSTRSWQLRLRGEVQRARVEGSHEVSRQMRDVQSWFRTAIDSASRETLAGLPQQVDAALQMVSGRISAGLGIRLSRLTDAALSDLFSPEELAVIRGQFARGATPPVVLRPPEKRAPTAEDKLLVFMGVSGGLGAGRLAAMPLAGLGVAALNPVVLPVTIVLGLGAGWWMARTRRHSADKQHLKQWLSDAIADARSTVDQLVAEQLIEAEQQLSLALDEALGRRVDAIEAELREVDKALRMEAGERTRALQSVTRKIAELSSGRSKVDDLLGRIRALRDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE8</accession>
    <name>A0A7W7WZE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="30158" checksum="2590C6004E5A0DBB" modified="2021-06-02" version="1">MARPGLSVVAAAGVCLVAYSFLVGLWPSRSGADLDLVLLVRSWVNLPTGLGEDFGFLGIALLLLVVGTRAERAVPRRAVLPVAAGVVLTAVLALAGAEPLVDDSVITPALTAGLALLLVNVVKPLLRRAPALAAFVLVEVACLLVLLGTAAGLPLLAAAAGLVPVVVWGLLAALRVEDRVSTRHLALVGLPGFAVLVAADRLSPDTLPFWRPLGAVYAVLLFAIALPRGADLAGRAAVRWLADRAVVLVVAVIAIGYPLLGLLGEVLPAAVTVVVGVLVTGVAGDLAYRGLRRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZI9</accession>
    <name>A0A7W7WZI9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F420-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="34477" checksum="849C1BC3DE85BA4B" modified="2021-06-02" version="1">MKIDQVAIEYDPRTLRASVMAGVDGFWVAETAHDPFVALSRVAGEVDVELGTAIAVAFARNPMSTAVQANDLQLLCEGRFHLGLGSQVEAHITKRFGMPWSKPAARMREFVQALQAIWTCWETGERLTFRGEFYRHTLMTPFFNPGPNPYGRPKIWLAGVGELMTEVAGEVADGFLCHALTTERYLREVTLPALARGRERAGRPMDIEISGPSLVVHDEASAREARERIAFYGSTPAYRKVLDLHGWGTLHEDLHRLSRRQQWADMAALIDDEILSAFAVIGTPSEVRTELEDRYGDIVSRVAAPSLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZL8</accession>
    <name>A0A7W7WZL8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">F4559_006826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="19590" checksum="205588DE2007BE21" modified="2021-06-02" version="1">MRTDAVVDSGAKAELARLVSELAVVHGKVTLSSGAEADYYIDLRRATLHHAAAPLIGRLLRQLTADWDYVATGGLTLGADPVATAMMHAASAAGEVLDAFVVRKEAKAHGMQRRIEGIEVAGQRVLAVEDTSTTGGSVLTAVSALREAGATVVGVATVVDRGTVAREVIEAEGLPYRYLLDLSDLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X044</accession>
    <name>A0A7W7X044_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase of the HAD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21464" checksum="89194CD1F129323F" modified="2021-06-02" version="1">MRWVVFDYGQVVSRPHVDLPGLAAAMGVPLEDFLASYWAHRDAYDRGDSDLVYWRAVGGGVGVDVSEEFARRLADQDTAGWLHPDPDAVALIAELDAAGVPLALLSNASHTFGRAAEKQPWTRHFRHLMFSADLGTAKPDPEIWTALADRIGARPRDCVFFDDRVENVDGALRAGLTGLLWQGTLTARTALAGLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXT3</accession>
    <name>A0A7W7SXT3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12015" checksum="F52AB7796E9D1834" modified="2021-06-02" version="1">MNNYINQYGENSHATQNNYGTDPTPPSPARTLLDVVEIVSRHRRNLMLRPDEAAEFDRSLALLANAAQHGNPHSAPALAAGRHVAATAGQLILGAGGEHLWMAFRTLIGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY47</accession>
    <name>A0A7W7SY47_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7865" checksum="C1B287BCB7AFCB65" modified="2021-06-02" version="1">MAMTLRLSDEENRRLDELAAVEGRSKQEVVRLALADRWSRLQKEEQLSEVLGRVLPKYRGLLERMGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYB0</accession>
    <name>A0A7W7SYB0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="791" mass="83651" checksum="9ACCD783224070D2" modified="2021-06-02" version="1">MLIPGPDTRVVELRVHGVQGTTPRSLVDAVEAVDVAGDGLGRVVRPADRLRRPAPGPVLQAGGRPVPRVVEGYVWGRMTSGGWAKATWALLFPFSLANVAHWMLPPVPRGSRTARVLGGVLRGLLRLAALLLTVMLVAQLAVISLDLVAAQCLAPGSTCLWGPLWISERPWARTLVGVAPIALGILVLHRVSSVDWRIERKDLPVSEDGMSGLPGAHVATDPDTPSLRVLHLVAGLGTAVVVALGGPLGPDSAARDHVGLWWAGAVLVCTSALATLLIDDPTGGAPHRGGRWLRAALGRRPRRVLLSAAWILLALTVVRLPHLPSQLPGTDLAVQVVAGTTAGVCGLLGLFLVPAALLARRTWSDLPRDLRPWAGGWMAAPVAAMAALLGGGFGAGVALALRSLLGHGVLPRGYDYITFLWGVGGTLALLIALGMGAFTGMMRWSSLRRDKEWAREAALLHTGRARDAKRAAKAWWWARWEQRHGHRVLLVCAFVLAGGAVPAAVLRLRGVDLFGWARPFATFGVVVLALLALSLLRAVWLAARRPDTARQVGVLADLAAFWPREAHPVVPPCYALKVVPELVSRVREHLAEPSTRVVLAGHSQGSLLAAVAVARLLEVLPPDQAERVGLVTAGSQLQWAYPRAFPAVVPHESLAKLAGGLQGRWRALCRGTDPLGGAVTTWDRQVFDGVLLGVGFRADGTTGALPAATRGPTGALVLGGDHWLPDPQRGPFTGRRWAAGVNKHRDYVSDPEWDRAVAAAAGLADATEPAPGPVLPAARKASVPRNETVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYS1</accession>
    <name>A0A7W7SYS1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="48"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26955" checksum="3FE01F9CDB5D8545" modified="2021-06-02" version="1">MPLLAVRRERPLWYFEVPLLIAGYFLFGLIRAAVDRGDPAATDNALRVQRLERFLHIAIEYPLNQAMLDHPVAIHATGYFYRLSILAVPVVLIWLYLTRPARYGRLRTVLVVTMLLDLPFVWLYPEAPPRFALAGIVDYMATYDILFSAESRIPRPGVNLLAAMPSMHVAWTTWCGYAVWSALRERAPRLSLFAWVFPLLTALVVLVTGHHYVVDIVAGVTLVGVSIGLTTLVRKRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV7</accession>
    <name>A0A7W7SYV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6621" checksum="42836F3CBBD9B38B" modified="2021-06-02" version="1">MGEDFVEEGWYVWRGRLNVAGNGQAGYWGVDINGKIGHFGPFGGSLQIGIDVFETAEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ29</accession>
    <name>A0A7W7SZ29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein kinase RdoA (MazF antagonist)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="33087" checksum="1D1716ADE7728CF7" modified="2021-06-02" version="1">MSPTSDDLGRALVDACARLGLDPAEAEPVRLGENAVYRLPGGIVVRISRPGQHHAAEKEIRIARWLADHDVPAVRALDSVAQPILSGDRAATFWEELPPHRHGTPAEVAGAIRRLHDLPVPDDLPLGDLDPFVRLRDRIDSALTLPAQDRHWLRAHLRTLEDRYLDLPPGLPARVVHGDAWVGNVVATADRRVVLLDLERCAVGPPEWDLVSTAIKHTSFGWVTAADYHDFCRRYGHDVTTWAGFSLLRDIRELRMTCYLAQRATEHPAARDEARSRVDCLRHRVGSRPWAWTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ4</accession>
    <name>A0A7W7SZJ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="44036" checksum="BCA6DC8245739B9C" modified="2021-06-02" version="1">MSLPTCARNATLRDLEAILRHQHAAKLDVVAPATAIRSERGAIVLSGVTPLLDERGVTTVDGRYVPTAAADGTIAAKLGISLRYLRRLRAERVDLFDANVNGWLHGHADNPPDPRSFLLRLFRRDDGDGVLRAMLSDSYGIIDNLDVLTAVLDGIRQADVDVEVRACDLSESAMHCKVYSPGVARLAPALLAGYRNPFSDPTLDAERRRIVTDLDDGRRAAQAEGQGYDEEPVVFAGFRFSNSEIGDGSVTLKPELFVRVCSNGLTLPALAVRKVHMSGRMEAGTVTWSRDTQNKHLAVIASQARDAVRHWLSPEFLAEQVDHVEQTAATPVTQPESTVKVVAKRLGFTDAEREGVLRHFIAGGQLTTGGLAHAITSFSQTVADPDRADALDDLALTAMTSAHRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM3</accession>
    <name>A0A7W7SZM3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="8628" checksum="CAA67815B3024E65" modified="2021-06-02" version="1">MSIIRLRDVDGDVHYTEQGSQAARRLLDEGAVDLDAPTTGGEVAADAAPAGPGDDHDPAPADDGPGQRKRAARTADRGAEPPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZP8</accession>
    <name>A0A7W7SZP8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33785" checksum="489D216EFB60D703" modified="2021-06-02" version="1">MTSPPAARVGTSSEARTSAGTNGRRADGGAPRNNGHTAVGHGRSSYPAAEARSADDVEAGIIALWHTYGRSRDQGMRDRLVLHYAPLVKYVAGRVGTGLPAHVDVADLIQSGIFGLVDAIEKFEPERGLKFETYAMQRIRGAILDDLRSQDWVPRSVRSRARDVERALERLGGRLQRTPTDRELAAELKIGLGELRELYAQLQLTSVVALDELIAAGRSAGAGSSLAESLPDEGAEDPIASLVDQDSRRQLADAIAQLAERDRVVVTLYYFENLTLAEIGKVLGVTESRVCQLHTRAVLRLRTKLNEQLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZQ6</accession>
    <name>A0A7W7SZQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Streptogrisin C</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_Al_protease" evidence="7">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="41602" checksum="29AE786B58CFACE0" modified="2021-06-02" version="1">MIALGFSGNSIASAAPDRSVDLPADVLAAMQRDLGLTAEQANTRAAQQEQADKIDDVLKAKLGASFGGAWFDANLGKLVVGVTDAKQAGAVTAAGGQAKVVKYAEAKLDQIVKGLDTQSGRVAGSSRSTNAKPASAAVKGLVSWSVDPTTNQVVVTALDGNRASKAVTGLKKYGDAVRVEYTADAPRPTVDFLDGGDDLNYPAGGCSAGFNMRNNAGQRFVLTAGHCGSAGQVVRGQGNVVIGVVAAAFFPTWDDALISVTNTGYWIQGPWVDVNPPNGGIITVSGYSNSPVGTAICKSGRTTKLTCGVITAKSQTVTYSGGTTVYDLVRHNACVEPGDSGGSNFRNTAVRTAEGVTSGAQLWWVGGQYRCGQVVGQPNVAWYYPAAISIPYYNAVYGAFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU8</accession>
    <name>A0A7W7SZU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15059" checksum="8DCA253CB562F02D" modified="2021-06-02" version="1">MELTGAVRFPDGAVVRGRGRDLPAGPSPEYGLYLAKRPEVPWHSEWLDWPDFRLPRDRARAIELIKDLHRRALAGEAVEVACLGGVGRTGTVMACVAVLSGVPAEEAVAWTRAHYHPKAVETPWQRRWVRRFPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX6</accession>
    <name>A0A7W7SZX6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uroporphyrin-III C-methyltransferase/precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase</fullName>
            <ecNumber evidence="15">1.3.1.76</ecNumber>
            <ecNumber evidence="15">2.1.1.107</ecNumber>
            <ecNumber evidence="15">4.99.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_001373</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="15"/>
    <dbReference type="EC" id="2.1.1.107" evidence="15"/>
    <dbReference type="EC" id="4.99.1.4" evidence="15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051266">
        <property type="term" value="F:sirohydrochlorin ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012409">
        <property type="entry name" value="Sirohaem_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036426">
        <property type="entry name" value="Sirohaem_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="14">
        <location>
            <begin position="164"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036426-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="42201" checksum="77EC0F173E113293" modified="2021-06-02" version="1">MQGEQHYLVGLDLCGRRVVVVGGGTVAQRRLSRLVAAGARVEVVSPEVTPAVEGLVDAGEAVWHRRVYADGDLDGAWYVLACTSDPAVNERVTADATASRVFCVRADIAVEGTAVTPAVGAHDGLLVGVLAGGEHRRSAAVRDGVVSALRDGSLADHHERPEGVALVGGGPGDPDLITVRGLRLLARADVVVADRLAPRELLDELSPHVELVDAAKIPYGRAAAQDFINTTLVEHAKAGKFVVRLKGGDPYVFGRGFEELIACAEAGIPVTVVPGVTSAFGVPALADVPVTHRGVSHEVVVVSGHVAPDDERSLVDWGALARLRGTVVILMGVERAARFAEALRAGRPGDTPVAVIQEGSTRSQRVVWSTLDELGADVVAHGIRPPAIIVVGPVAGLAAELPFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ6</accession>
    <name>A0A7W7SZZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="10871" checksum="4F0294DCB8AD55A1" modified="2021-06-02" version="1">MSGVDAAITLAHRADWARVVPVLTKRFGDVDVAEEATAEAFATAVERWPADGVPPNPGAWLTTTANARPSTGYGVRAKATTSTGRPGCCATTTPNPSVPSTTTDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T029</accession>
    <name>A0A7W7T029_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="40351" checksum="F9460ED154BA9AB7" modified="2021-06-02" version="1">MTAYVDRCSSRTREWVCEAVRIIEADANRSADTHLLHFPLPAEWGIDLYLKDESTHPTGSLKHRLARSLFLHAICNGWVVGGTPVIEASSGSTAVSEAYFARLLGLPFIAVMPRSTSREKVALIERQGGRCHFVDDPRAIYDESRRLATELNGHFMDQFTYAERATDWRGNNNIAESIFDQMGLESAPEPEWVVVGAGTGGTSATIGRYVHYRKLRTRLAVVDPEHSVFFDAWCSNDTDLVGTRGSGIEGIGRPRVEPSFVPQVIDRMFKVPDAASIATVRHVEEVLGRRVGGSTGTNLWGAFQLIAEMRASRQRGSLVTLLCDGGERYANTYYDDDWVAAQGFDLSPYLATLVRFRSSGVWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T031</accession>
    <name>A0A7W7T031_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="30101" checksum="B63352A730FB62B5" modified="2021-06-02" version="1">MVAPDPVDARLLAMIAEMGRAAVHEVAARLGMDPREAATRLITLSGSGLPLLVGVECDPNGIRKALANSVAWGNYAGPSGVRGTPSGSYAPGTVRGTPSGAYQPGPPSRPVPVQHPSGPVPMQTPVPEPMSTWGPPQSAGWVRGEGPGAPRARTGKVGGTLETEGLEGARFTIQLVEVVDPADFLFTAAGYKLGAGERAVVVHTELSNIGSVPFNALPDMYLVLMTASGEAVAKAPVSLSSRPAHKIGVQPGETAGGHTVYVLPENTPVTSVRWSARPETDLNTLVWTVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C3</accession>
    <name>A0A7W7T0C3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="5788" checksum="9636ED6F726CFF8D" modified="2021-06-02" version="1">MPTSEPQTAVLADHADAAEICVACPHPWHEHDPLSVRFCTATTAVALSRGCICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G4</accession>
    <name>A0A7W7T0G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enamine deaminase RidA (YjgF/YER057c/UK114 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13878" checksum="94E146A0449E8C35" modified="2021-06-02" version="1">MRRIVLSGSTFEESIGYARAVVDGEWVHVSGTTGFDYTTMTIAEGVVAQAEQALRNIEWALKEADASFADVVRVTYYLPDAAEFEPCRPVLRAAFGDVRPAATMLEVGLADPRMRIEIEVTAHKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K5</accession>
    <name>A0A7W7T0K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator GlxA family with amidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15253" checksum="40FAE10B1562FCA9" modified="2021-06-02" version="1">MTPEELAHLRRARDLMDREYARPLDVPAMARAALMSPAHFSRQFKLAYGETPYNYLMTRRIERAQALLRRGDLSVTEVCVEVGCTSLGSFSTRFTELVGESPSAYRARSHEAMARVPACYAKTATRPSRIREARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T3</accession>
    <name>A0A7W7T0T3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23025" checksum="ECD6E792F4445118" modified="2021-06-02" version="1">MLAQLRSEFPDVTISKIRFLESEGLVRPARTASGYRQFSTADVERLRYVLAAQRDRYLPLKVIKEQLDAADQGVPQRALRAVDPTHVTREELLARVSPGVLAELERSGLIRPGPGGSYDGEAVRIAATVRAMAEFGVEARHLRAFRTAADREVALVEQVVAPLYRQRDPQARARADEAVRELSALAVTLHALLVKAGLREAGIGRVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T9</accession>
    <name>A0A7W7T0T9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type bacteriocin/lantibiotic exporter with double-glycine peptidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8285" checksum="EECA5D8D71339B7B" modified="2021-06-02" version="1">MSTRTETVEAEMPRAARAGSNGAAALPTAPCSVVWSKGHAYVLEGFRARWVGVDDRGRPRTLSGAELQRQGWSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S0</accession>
    <name>A0A7W7T1S0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PrcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prcA</name>
        <name evidence="5" type="ORF">F4559_002346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_B">
        <property type="entry name" value="Proteasome_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28368" checksum="805804304FBDAE35" modified="2021-06-02" version="1">MTMPLYASPEQILRDRSEYARKGIARGRSVVVLRYADGVLFVAENPSSTLHKVSEIYDRIGFAAVGRYSEFENLRQAGIRFADVRGYQNDPRDVTGRSLANVYAQTLGSIFTEQIKPLEVEICVAEVGVRPADDTLYRLTYDGSIVEEPQYSVMGGQADATSTALKDAYAEGLDLADAVRVAVKALSAGSTSTGNGKELLGSNKLEVAVLERDRPRRAFRRIGGDALASLVAPPEADGEAAEEPVADKPVTDVNLPPNDDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T207</accession>
    <name>A0A7W7T207_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="27177" checksum="E104F4C0FDC0DC5E" modified="2021-06-02" version="1">MAGKSEAAARAVDVWKSYGTGEAAVTALGGVSVELDRGRFTAIMGPSGSGKSTLMHCLAGLDTIDSGDVWIGDTKVNGLRDKGLTELRRDRVGFIFQQFNLLPTLTAEENITLPLAIGGRKVDRAWFDLVVETVGLRDRLSHRPTQLSGGQQQRVACARALVSRPQVVFADEPTGNLDSRSGAEVLGFLRRSSTEFDQTIVMVTHDAVAASYADRVIFLADGRIVRELHHPTADAVLETMKNLDGDEELVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T248</accession>
    <name>A0A7W7T248_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="25910" checksum="20927CEA981E3E72" modified="2021-06-02" version="1">MGSGFVASWSGFPSLCERWATQILWDGSVVDIVPGTTSGSSSLKVPSGSSLGAHTVSVFNPGCKVTSSATFTVVIVAPPTTTTPRVPPTTTTTTPPRVPTTVPGSTTTTGSTTTTTTGTSTTTAPETPSGTSSVGPTTTLPFEGDGALTLDKDNIQPGDPLTAAGTGCEPGAFVKLSSSGESVGSTKADTAGRFSTRVEFASLEPGRQVIRADCGIVLVGAVDVALTSSTSGTTSTLVVLVFFVLAGALLIRRQFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T276</accession>
    <name>A0A7W7T276_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cadmium resistance protein CadD (Predicted permease)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004676">
        <property type="entry name" value="Cd-R_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03596">
        <property type="entry name" value="Cad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="19862" checksum="6E09F057AD80DD8E" modified="2021-06-02" version="1">MNATLLLKAASMFAVTNIDDLLLLAVFFGRARGRVAVLEIVAGQYLGFAAILAVSVLGALGAGLLPETVIPYLGLLPLALGLRAGWTAWRGRHEEEDDVRGAGLWSVAAVTFANGGDNIGVYVPVFAVAGTAGMVGYLVVFLAGTALWCAAGRFLAGHPVVGRALSRRGHVILPLVLVAIGVTILVEGGAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2B5</accession>
    <name>A0A7W7T2B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="373" mass="38499" checksum="BDB1E736FFE211F6" modified="2021-06-02" version="1">MAGVNRWSRARAAERFAGLGPLLWPSLPWGLAVMALANLAQLLAHWSSYRNGPVVVAVLVGLAGATALVWFRSRTGLGPVAAGVGVLAGPLACVVIATQLPADQLTGLANWVSGFAVAPVLLLPFSRPVEEVVAALAALVVVQAVVLEGVTGTPRQLHAVVLSGGAAAAIGAGTALLVGVMRATVRAGRDLAVRAREAEWERIARTAAVGRQDVVVGAVEAASARLLDDIGHGRRDPASPDVVAECARLAAALAPDLLHRSRLPLLEVQLEPAVADTGAVLVVHDDEDLVRRLAITDRTLLVRALDDVLSACAAVEVTVLPVDGRAHVMLAVTGAGPDTPGWHDLVDRFGGSTTPTGSGLFHDFYAPLTGRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Q1</accession>
    <name>A0A7W7T2Q1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMNH2-dependent dimethyl sulfone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024014">
        <property type="entry name" value="DMSO2_SphG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04021">
        <property type="entry name" value="LLM_DMSO2_sfnG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="40907" checksum="4FD53C7814B9C54C" modified="2021-06-02" version="1">MPEERERGPLKFAYWVPNVSGGLVVSTIEQRTDWSYEYNRALAVLAEDNGFEYALTQVRYLASYGASYQHESTSFSLALLLATQRLKVIAAVHPGLWHPAVLAKLIATVDHVSGGRAAVNVVSGWFKGEFTALGEPWLEHDERYRRAEEFIRVLRASWTEESAEFAGDFYRLRGYDLKPKPLSHPEIFQGGNSTAARAMAGRVSDWYFSNGKDFEGVSEQVADVTAAANGRRVRFGLNGFLIARDTEAEARETLREIVAKADVPAVQGFRDAVAQAGASTADRRGMWADSSFDDLVQYNDGFRTRLIGTPEQIAHRIVEYKRRGVDLLLLGFLHYHEEVAYFGRHVLPIVRALEADLPAEPIGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T1</accession>
    <name>A0A7W7T2T1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030858972" evidence="1">
        <location>
            <begin position="31"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="19984" checksum="C5C17C46945F4113" modified="2021-06-02" version="1">MTPPLRTVAALAVVLVLLACTKTEPGHPAAAPTTSRAPVPDLDIEKYLDAPCAILTREQQAELGTFRAVMPVRKPFGPSCEYLAPNTARDPSYDITFVGRGATIGEMFSRLKDAGMPVYQETWIAGRRAVVWDNVDGKSACVAGVATSEENGVSVVVTTASLVENRRGDPCETARRLAATVLANLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W5</accession>
    <name>A0A7W7T2W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="11996" checksum="9100354C2BE17CD5" modified="2021-06-02" version="1">MSIKDVTAPLDAVLGEIDATRESLNLAVGLIDDATTPLGSAVSGTADPDALQTLAWFGEPVRFVFTALKTSYQGDAGRRLDRDRVPRAPSVRITREAGSRSGCSGRVLPVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T326</accession>
    <name>A0A7W7T326_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="27635" checksum="330CC63F7C0E05E4" modified="2021-06-02" version="1">MTEIVNTHQSEAWNGYEGTHWADNHDRYDALNGAYNPHLLAAVGAGDRVLDLGCGNGQVTRLAARRGAHATGVDLSAPMLARARSCAQAEGVDNVTFEQGDVQVHPFAADSYDVVLSRFGVMFYADPVAAFANVRRALRPGGRLAFLCIRGLGDLGPVLRAIGGPSPVGPDGSGPLSLSDPDVVRRTLTDAGFTDIGVAAVDEPQWWGADVADATAFLLAWGPVRHALGEDTSHVRDAVAAALAPHAGPEGVRLLGNAWLVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T343</accession>
    <name>A0A7W7T343_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="34904" checksum="59336B28E00BE624" modified="2021-06-02" version="1">MRIQTASVQFCHRAGDKAYNLATITRFVREAADRGVRLIVFPEMCITGYWHVVGMDRAGIEALAEPVPGGPSVTALLALAREYDMVLGAGLIESADGALHNTYVVVEPDGSVHAHRKIHAFESEHITPGRDYTVFSSTLGCTLGVLICYDNNIVENARMTALLGADILLAPHQTGGVASRSPHAMGTIDPALWAARDTDPEAIEAEFRGDKGRGWLLRWLPSRAHDNGMFLVFANGVGLDHGEVRTGNAMIIDCYGRIVAETWRARDEMVCAELDLSLLARSTGRRWLRGRRPELYGPLAEPTGRELDPLEARFSTDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C8</accession>
    <name>A0A7W7T3C8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="900"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="942"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1236"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1278"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1320"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1404"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1446"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1547" mass="166877" checksum="4F046DEF4D1D52AF" modified="2021-06-02" version="1">MDLRRIPPGAARARLDRMQMGDADRAAVETLLGVLGDDHETPVERALEALFGERTPGAATKALERLVKVVNAVAEAEEVDLTLEVRGGRKLGARGRTVGFSAHHLEPARDPLRERGAVGDALILDRHATVLGPRRIVLCHAPDDADPASRLWDRLIEAVGAEGPRLSWWRADRDVVAGDEPESRLRQALSKGELAVVALSNSWRAAPGLDAIVRDHRRTAGLHVVPVALRPERARTGLPEDDPVTFYCPEGRTFMDLRGPAAVDRWVNGLAAQIERLLARPEGRASESVPHPLPEIVLADRRALRDDKDDRYYKLFSQLGNMDPDVRSVSADGRPVDDVVAFLTRWAHEPDSAPLAALLGEYGTGKTITCQELTERLREDPTGPETLYFDLRRLGGLDHGVPALADILTACIKGGWVPGDLPLPTGEQIIARAARTPTLFVVDGLDEVLVRLDTAQGVAFTHELLKLRPIRTRDGVRAPFAGAHTKVLISCRTHYFRSLREQSRHFLEHDRDLATAEDYHAVMLLPLADDQIRDYLAKTLPDRDAAAVMDMLRAVHDLSDLATRPYTLTKVAAQVPFIEQRLAHGRPVHAATIYRQVLRDWLARDRGKHRLRPDHKLTLMARLAAWAWKRGDRRLDAAELDDWLDEQLAEDPVLRRRYRTWSRDQLEEDLRTATFVTRGDHHGPDRPDFRFAHSSIHEYFLAQYLCDALREDRREDWCLPVPSAETLDFLGQLILDDDEPDALLTRLGRWRAPYVAEASELWLRYLLHAREHGLPHPLPAASDLSGAALRGWHFTGTEGDPLAFTGATLTGADLRDTRWDHVNLTGAILDRARLERAVLHDVTLTRASVRGADLSGAFLRRCRLDDTDLADAHTHRLRHHDCGTALPEPATPHHTRLHPLTGHGGLVWGVAFGPDGSRVASAGGDGSVRVWDVVTGECVVTLSGHGDWVRGVAFGPDGSRVVSGGDDGSVRVWDVVTGECVVTLSGHRGSVRGVAFGPDGSRVVSGGDDGSVRVWDVVTGECVVTLSGHRGLVWGVAFGPDGSRVASASHDGSVRVWDVVTGECVVTLSGHRGLVWGVAFGPDGSRVVSGGDDGSVRVWDVVTGECVVTLSGHGGSVWGVAFGPDGSRVASASHDGSVRVWDVVTGECVVTLSGHGDWVRGVAFGPDGSRVMSGGDDGSVRVWDVVTGECVVTLSGHQGLVRGVAFGPDGSRVASASHDGSVRVWDVVTGECVVTLSGHRGSVRGVAFGPDGSRVVSGGDDGSVRVWDVVTGECVVTLSGHRGLVWGVAFGPDGSRVASASHDGSVRVWDVVTGECVVTLSGHRGLVWGVAFGPDGSRVASASHDGSVRVWDVVTGECVVTLSGHGGSVWGVAFGPDGSRVMSGGDDGSVRVWDVVTGECVVTLSGHRGSVRGVAFGPDGSRVMSGGDDGSVRVWDVVTGECVVTLSGHQGLVWGVAFGPDGSRVASASHDGSVRVWDVVVGDPVWLATQFSDGSTASWSPTEDRLLDTTEGAWRYLRAACYDDHNRLLGLQPHELYYAQPNPNARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3F5</accession>
    <name>A0A7W7T3F5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7457" checksum="90CD7525ACF67322" modified="2021-06-02" version="1">MDRVRAVLGERTAGLDAVARAVADYLAAARGLGRVAPTTDPEAPALVGVPTAPNDRERLRRTIAALVPPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I7</accession>
    <name>A0A7W7T3I7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate lyase</fullName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Isocitrase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Isocitratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="PTHR21631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="307"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="45962" checksum="019B9C6C9C9ADA2D" modified="2021-06-02" version="1">MSTAEEITREWATAPRWAGVRRTYSAADVVRLRGSVVEEHTLARRGAERLWELLHTEDYVHALGALTGNQAVQQVRAGLKAIYLSGWQVAADANLSGHTYPDQSLYPANSVPQVVRRINNALLRADQISHAEGTSSAHDWLAPIVADAEAGFGGVLNAFELMRAMIAAGAAGVHWEDQLAAEKKCGHLGGKVLIPTGQHIRTLNAARLAADVAGVPSVVIARTDAQAASLLTTDVDERDRPFVTGERTAEGFYRVRGGLEPCIARGLAYAPYADLLWMETSTPDLEVARRFAEAVKAEYPDRLLAYNCSPSFNWRKHLDDATIAKFQRELGHMGYRFQFVTLAGFHALNHSMFDLARGYAESGMAAYVGLQEREFAAEADGYTAVKHQREVGTGYFDLVSTTLDPTGETTALAGSTEQAQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3K3</accession>
    <name>A0A7W7T3K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
            <ecNumber evidence="2">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="480" mass="51579" checksum="65226468A107C1AC" modified="2021-06-02" version="1">MSFQTAEEMTAALCAGEVTSADLTDEAIARIERDDKAINAICVPDFDRARAAARAADRARARGEVRPLLGVPVTVKESYDMAGLPTTWGMPEHRDFVPAEDAVQVSRLKAAGAVVLGKTNVPLGLQDIQSFNEIHGTTNNPWDHERTAGGSSGGSAAALASGFGALSIGSDLGGSLRTPAHFCGVYAHKPTLGLAAHRGMVAPTEPASPTDPDLAVVGPMARTARDLALLFDVMAGPDPLTLGKAYDVTLPPARHERLRDFRVLVLDDHPFIPTGSAVRAGVNRVADALADGGARVERHSPLLPDLTEAAILYAQLLVSGSVARFPLDEEQVRTRVAGLDVDDRSLDAARLRGMVFSHRDWLEVNARRELHRRGWRRFFAEFDAVVCPITPTPAFPHDHDPDPLARRIDVDGVEYPYFDQLVWAGLATMPGLPATAVPADRSPEGLPVGVQLIGPMFEDRTPLRLAELLERAIGGFRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L4</accession>
    <name>A0A7W7T3L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7184" checksum="B710FD0306E81979" modified="2021-06-02" version="1">MERIPVGWRAALAVWGVLCLLSLLGWVALGVSGSGWTFPYWLFGFGVMIVWLLLAVFVARSRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T415</accession>
    <name>A0A7W7T415_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide transport system ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="342"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="518" mass="55030" checksum="2BD22A5527955771" modified="2021-06-02" version="1">MTSHAPVRAAHVRLSDVHVSFGGRPVLTGVHLVAAAGDRLAVVGENGRGKTTLLRVLAGGLAVDRGEVRRAGSVGVADQQLPLGPDDTVGALIDLELAAVRTALARLDEAANGLAEGRPGADDAYADALAEVEDLDAWDADRRVEVSLAALDAVGDRSRPLGTLSVGQRHRVRLACLLGAGHRVLLLDEPTNHLDASGLGHLTERLRAYPGVVVLVSHDRALLADVATTVVDLDPSSDGRPRVYGGGYHAYVDARRAERARWEALHADQVAERQRLADDLSAARNRLRDNWRPDKGHGKHQRATRAPGLVRAVHRRQEELDAHVVEIPPPPTAFTLPELPGRHGTTVLRADGVMVAGRLPGPVDLAVDAGDRLVITGPNGAGKSTLLAVLAGALAPTTGTVSHPRQVRIGLLGQESDPPGRRTAADLLDGHLFGLLDGYDAHRPMAELSVGARRRLDLALVLAARPHVLLLDEPTNHLSVTLVDELTAALASTPAAVVLATHDRQLLRDTRSWPRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A2</accession>
    <name>A0A7W7T4A2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="43481" checksum="C2EE8D27658DC73D" modified="2021-06-02" version="1">MELVLPRPADSLTVILKLAGAACNINCYYCYEKRKPYPDENWLSPETLGKFLVAAGNRPLRIVLHGGEPLLIGPRRMRPLLELLAGYPGTVELTMQTNAMLLTDTWIDLFDEFFPDIDIGVSIDGPREANAHRVDYRDRPTFDKVLRGIELLRRRGKTIALCITVTDLVLGLAAETMALVADFPHVRAVRLSPCLDYNVSTLKFPKANAPSLLALNGKGRGAAGWSTTPTEYARFVADCFDVWHREYFQRFLVEPLFSMLLHFTGAEVTLTDWSVLKEPFIVALYPDGTIGASEEISTPDAAIGTVDTVGSLDEIVRFQRNLPLVTGMRELLERCSSCSHVSVCSGGSLADRLRLRDTEWDSEYCASRKWLIDYVRSGCERYGLRPSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4D4</accession>
    <name>A0A7W7T4D4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="33122" checksum="45489ED4A81465CD" modified="2021-06-02" version="1">MATLNRGMWDRGRSRLIDYAARALSGYDTVVSRLREAAREHESEETRQYLALFEQDNEDLRTQIAEHKRHTAEMVAERAYLVEELEALQGENVDLRHRWDDARRKLALVEPLLWRDHADAMAAFAESPTPDGVESAGDAALFAQAYLSDHLVLPDSACVDLEAIDTAVESKAWGQTSLRGFLALHAYGRALSAGEPGSFWTWCVNSGHPYAWTATSKKLAMAESATVKNTDKLRAKRIFEVDPSVDPSGHLFMEAHLKIAEGGGNLAPRVYFHPSREQGRVHVGYFGPHRNVPNTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F4</accession>
    <name>A0A7W7T4F4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="25523" checksum="C082A667C973005C" modified="2021-06-02" version="1">MFTGKVALVTGGGSGIGRAVARQLALQGATVMITGRDDRALKETADNIKATGGQADWLTTDVTDEAQVADLITTTTARHGGLHVAVNNAGVLGPAGIPTADLDRKAFTEVMDINLMGTWLCMKHEIAYMRTNGGGTIVNVASNIGAHSRRPGLAAYAASKAAVSALTRTAALDHVADGIRINAVSPGATATSMSRRPGESDADRDDRLAGAIPLGRVGATDEVAAAVLWLASPASAFTVGHDLVLDGGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W5</accession>
    <name>A0A7W7T4W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YuzA (DUF378 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025492">
        <property type="entry name" value="DUF4383"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14325">
        <property type="entry name" value="DUF4383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="15512" checksum="9F04EEB1CF8F6388" modified="2021-06-02" version="1">MSSTTTTRTPVQTAALALGVVFLLVGVAGFIPGVTTDYDALSFAGHHSEAELLGIFQVSVLHNIVHLLFGVAGVALARAANTARAYLIGGGAVYLVLWLYGLLIDHDSAANFVPVDNADNWLHLGLAVGMIALGVALSRPATPRDGHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T550</accession>
    <name>A0A7W7T550_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15647" checksum="6D730CC9C8EEC4AF" modified="2021-06-02" version="1">MSTPTFDPHDLVAEARLSVLATIKADGRPQLSPVTHHYDRENGVILVSMTDGRAKTRNLRRDPRATLEVTSADGRSWATVEGVATLTGPGTDPNGPEVEALVAYYRSAAGEHPDWAEYRSVMVSDRRVLMTMSVDHVYGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P0</accession>
    <name>A0A7W7T5P0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031418442" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="42"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="34260" checksum="A5849E605DD9AAC5" modified="2021-06-02" version="1">MTRIHAARAVALGTATALATALGIVPSAGAQPTAKAEYQWVALGDSYTAGVIPASGDTFEVPRDGCERTDRSYPQVIDRDLGALFELTNVSCGAATIEDVSFRAQQPIGRHLPPLVEDPDYPFPPVPPQSEAAGSDTDVITVGVGGNTLGFAELLLQCLRLGGDAGGVGTPCRDAQSDGIRARLDKVGSDYEELLRVLHERAPKAKILAVGYPTVIPGNAADCEYNNFEQFGSVTPEDLDWLRKDVLEPLNAVIKAAAETHDATVFVDLYESSRDHSVCAATKWVDGIFTQVPDQMAFVHPNAQGHRNAADHVTEALLNTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q6</accession>
    <name>A0A7W7T5Q6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding LacI/PurR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35588" checksum="FFD37DF4A6B44D38" modified="2021-06-02" version="1">MPTKRPTISDIAKAAGVSTGAVSYALNNRPGVSEPTRRRIRDIADRLGWAPSSAARSLSAARADAIGLVVRAMDTEPYFLQFLAGVQGALDTTALVLQVTDDPRAELAAYRRWWAERRVDGVILVDLLDDDPRLALVRELAMPAVAVGDAADLPAIRTDDATAVTEVLDYLAALGHRRVVRVAGPTRFRHTTVRTDAFERAAGRLRIDEARVVHADYTAESAARACRRVLMSADRPTAMILDNDVMAVAALGVAQELGIAVPDGLSLVAWDDSPLCDLVRPALTAVRTPIAERGAAAVRLLLDLVAGVPPRTVRTSDPELVPRSTTTPLRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5W0</accession>
    <name>A0A7W7T5W0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-amino acid N-acyltransferase YncA/DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30233" checksum="3375488F495E2AE2" modified="2021-06-02" version="1">MMPITLQDDDAATYAKWFACLADPTRVRLLHTVATHPDEMTVGALADAIGITQPTCSHHLRKLAEVGFVRLRKERTATLVSVNPACCTGLPHAADAVMGTIVTRPCCPADLPGDVTVRALLDGDWTDVRRIYAEGIATRDATFETDTPSRRTLDAKWLPDHRWVAELDGEVVGWAAATPVSTRDCYAGVAETSVYVAAGARGRGIGKALLHKQVTAADTAGLWTLQTSVFPENRASIALHHAAGFRTVGVRERIAEHHGVWRDTVLLERRAQTPPTCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T603</accession>
    <name>A0A7W7T603_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14010" checksum="CAC187149A2F083B" modified="2021-06-02" version="1">MSSEDSTAIRLDKAGFYLFRQAVVEVREAGPDDPALARVTAALEAVRPALDALDRYTVDLTVGVHDGDPVITRTGDDSVTVAGALTSDVVRRLPDAFRRVADELGDPEARYRTGGDVAALKALADRVDRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T671</accession>
    <name>A0A7W7T671_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030979193" evidence="5">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="26564" checksum="B0401BC6B435ED11" modified="2021-06-02" version="1">MRRPGVVLALLVLAATVVCAAVPDLVAAARPDAVDPFGALRPPGADHLFGTDQLGRDLFARVVHGTRRTVLVAGSACVASLLIGSLVGVVSGMLGGWLDALLMRAVDVLLAFPALLLSLTVIGVLGSSPVNVAVAVAVAGVAPYCRVVRAQVLHVRTRPFVAAATVSGVRPVAVLLRHIVPNAAGPVLVLALMSLGVALLAASSLSFLGFGPHPPDADWGSLAASGRDYVGTAWWLTAFPGAVVVAVVSAVTAVHRAVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K5</accession>
    <name>A0A7W7T6K5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-lactamase</fullName>
            <ecNumber evidence="6">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="850"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1170" mass="125073" checksum="761483391BA9A206" modified="2021-06-02" version="1">MGDDIVSVLALFFGGPTAFGRLLILTGLALALVNCFRFLVARPAVALAADGAAPTVRHEGGARFLRGAGPALFGPPVLVLLGACSATFLITPWYVITAAPLFAAVVVAVRRLRAEHGRRGEDAVAGPVLAVVLSTTTLVLVGVIMTVRLVVQPDPTSGFADSDRGTVTDVVFSLAIPLLGLLGLMWWERLRVVDRLPWRPRKPVLLYWIGIGAVVLLFVAPLLDLNRNDNLAFFGIATPEYGKVLYIWVLAVVLARYAIGFQVRPGALRWRPSVARLRRAAAKGKHVGYIFLMFGLVGVAGLIKTDIGPTIPTFFATVTIVVFLLRLQVRSGTRLLDTLNSSRSLWAALLLTGLIAYFVLQLDYVKTRQEAWHQPWTFGWSTPCAPPPEGVEPPKAPDGTTACLESLDAVAAGKRSQVAQSMSAVADGGVWGRGLSDTGAGRLPAGSTDFILAVLWNKLGGFAVVLLALLLAVLAAALARCRSHLDKFADERADLPGADRQSRAARLFAVGVAGMLVGQFGFVFVTTLNVVPHSGITVPFLSRGGHSTLALVGAVVAAVWLLYRADRPPRPKAATEARTAVVRTAPMGGMWLPKVRRVLPLTFVAMFVGTTLLATTITIAPYGRYAQDRPYCPVTRVRVDPEVCSTDRIANRRTRVELRVGGEPVYVRDRSEQAWQAVGTPAVTLSDLAGLIRLNGRGGTLNNTLDDLIDRASGTSLKERVLPTPGGPEAGLIDLTVDPALQRSLTGALRADAEESKPLAGGIVVMDAKTGRVLAASSAPSALDWPVVEPVEADKKAVEAFGDDHTVYGPIENGKVVTTGDDCDDTDWDDRCRRWILETAPTTPNPKALEEQRRYAPDTPDEVLPSLDENRALDRRYGLGSTFKVVVAAAFLKNRPGSTAQSTIPSPTVYQPPFGKPIRNYNKGACQGTANERITLKQALTVSCNTAFVALADELGWDAVRDMAVEMGFADLSAQGADDAWLAGPAAGSASYVPPSVDTDGMDSLGNNTLGGGRVEGTAVQMATMMTAVANEGRVVQPTLVAATAEPFGRDQVRYSGEVREVLPSGQARELAEALSGVTQNDDGTAHRLKAEPDRALRVKTGTHEIYGEDETPPDKRFAKQNAWVVGSLDTKAGPVTFAVVVETKVEKDGSRRAQWLTQQVIDKVVEVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T5</accession>
    <name>A0A7W7T6T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoenolpyruvate synthase/pyruvate phosphate dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="65"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="303"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="430" mass="44341" checksum="BEBD265E6AF6A947" modified="2021-06-02" version="1">MSHVHPLVPAPVRLVGAKAQGLATMLGLGLPVPPGVVVDTAACREFLGSGRLPTGLLAELTAAVPDGPLSVRSGAAVSMPGMMSTILDVDRAHLESAVEAVFSSWNTPRARTYRALHDIPHGLGTAAVVQAMVFGDRDPHSGTGVAFSRDPNTGAPTPYGEVLFGHRGTDVVSGSHLTSPLAALDREPGVWHDLRSALATLEGHYRDVCSVEFTFESGKLWLLQARAGGLVGTAAVRAAVDLAREGRIDRTRAVLRVDPRDLAEVPRIADPTPLLGRGTGAVPGVAVGRVATTADRAARTTGPVILVRPETSPLDLHGMAASVGIVTARGGPTSHAAVVARAAGTPAVVGVRDLVVHEGEARFGSTVVRDGTVIAVDGGGGLVVEGRPDITTSPSTHMRTLLAWADEISGTTFPSAPERLATAHSALRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7F7</accession>
    <name>A0A7W7T7F7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">F4559_005300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14775" checksum="811FA08D6C21E6C9" modified="2021-06-02" version="1">MSERTLVLVKPDGVSRGLVGEVISRIERKGLRLAALELRTVDEATAKQHYAEHDGKSFFNDLVEFITGGPLVAIVVEGTRAISAFRQLAGGTDPVEKATPGTIRGDFGLEVQFNLVHGSDSVESAEREIKIWFPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G3</accession>
    <name>A0A7W7T7G3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010662">
        <property type="entry name" value="Hydrolase_RBBP9/YdeN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06821">
        <property type="entry name" value="Ser_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21569" checksum="F7DC4CA35D43DBF6" modified="2021-06-02" version="1">MSGEVDGLSLPYVLVLHGLNGSGPTHWQNWLAGELARHGGLVDLPEFSEPDAPDRQRWLDELRGHLAAAPTSLERVVVAHSLAGLLWLHHAASGVDPVLRVDRVLLVAPPAPDFAGEPLIAGFLHPRLDPTALRQAGVSTRLVLGEGDPYCTLAQGKALAEAVRIEVDVVVGGGHLNVGSGYGSWPAVLKWVRNDRTPLTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G4</accession>
    <name>A0A7W7T7G4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24537" checksum="AAD45C0DBEF92878" modified="2021-06-02" version="1">MTPDLTIRDLLFRDVDGEYSTEPDTVIDGAATEPRYLERVPALKRVLAESTERYHRYLAVVALATWGEPEAYPIVERVAREGRDTEWFGMFKDVEGRDTTFPTIAGAVAEGRTFAVVAGGENHRLDAVRALLARAGDLYFGWQLRYAADDPLVADALADAVGAAIGVERTDFDVELQLADLITVLAGYDRERAVDLAERLLATDRRMIVRTHLSPVVPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T869</accession>
    <name>A0A7W7T869_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="120"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="38939" checksum="61219DCD54DACD70" modified="2021-06-02" version="1">MFPTADDVRKALAGVHDPEIKRPITELGMVKDVVVGKDGVVDVAVYLTVQGCPLRDKITADVTAAVSGLPGVTGVRVALDVMSDAQRTDLRKMLRGGVDEPVIPFAQPGSLTRVYCVASGKGGVGKSSVTVNLAVAMAARGLSVGVVDADIYGHSIPRMLGTEARPTQVEKMIMPPQSHGVKLISIGMFTPGNTPVVWRGPMLHRALQQFLADVFWGDLDVLLLDLPPGTGDVAISVAQLVPNAEILVVTTPQQAAAEVAERAGSIALQTRQRVAGVIENMSYYELPDGTRADIFGSGGGAAVAASLTAAVGADVPLLGQVPLDPRLREQGDAGTPIVLAHPESPAAGVLTDVARQLSVRSRGLAGRLLNVSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I5</accession>
    <name>A0A7W7T8I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="15870" checksum="08608087844D9D59" modified="2021-06-02" version="1">MNGWVLRGGIGAGALVVGLVLAAEGVDWLAVGLYLALAAVTAAIPASAAAVLLVGYPAVAMAFVEDAGVVAVSALVVLLHLLHLTTAYAAVVPVSARLDVAALRAPAKRFGLVQLAAFALVGVVYLIPPGTTDETVELVGLTAAAGLVVGTVVLLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8L3</accession>
    <name>A0A7W7T8L3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-methionine transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015821">
        <property type="term" value="P:methionine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="34419" checksum="715C6DF6CC57F2B0" modified="2021-06-02" version="1">MITVENLTKSFPGGAGQVRALDGVNLEVEAGTVLGVVGPSGAGKSTLARCVALLERPDSGAIRVDGTDLVSLGGTALRAARRQIGVVPQGDSLLRQRTAAGNIALPLESAGVPGPQRRTRVAELLDLVGLTDKAASYPDQLSGGQRQRIAVARALAASPSVLLADEPTSALDPDTTGSVLTVLDRARAELGVTVLVVTHDMGVVRKICDDVAVLENGRVVEHGKVLDLVSDADSRTASSLLPAVDQNPASEGRYDRVADVVLVGFAAVGALLPEATSRFGVDLNLLGGGLTRLGETPVARFRVGLSGERADSALEWISEAGGAVRRAAKGPQGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V6</accession>
    <name>A0A7W7T8V6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24609" checksum="1DFF6D49CE16C212" modified="2021-06-02" version="1">MTTSESASTPWVRGARFGWSKPADYSVRLFVVVMDAVTADPERVWSVSELARESGVKRSTVRLVCADLAASGQARVSHKQGEPSRLLPTKLYRVRPECVTAWVSVWRDRFYRADALTDAVMGARLADGLARSTDAIGYSVYSLEQVVGRLLAGGRRSWTARDLGDTAGLNCSTVRLVCRDLVAVGHLTVRIEEDATRSIPRKFFRLTDAGRAAWRERFENNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C1</accession>
    <name>A0A7W7T9C1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8567" checksum="C14E4CFFBA163CEA" modified="2021-06-02" version="1">METWRIVATGSFLLGGLVLVLVGMAQARDRKGSRPADVKRAAFVGLALVGIVAVLVAYVLPSVAAWGVVAATAIAVVFITMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F8</accession>
    <name>A0A7W7T9F8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system OmpR family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="25663" checksum="1E72345A68CA226C" modified="2021-06-02" version="1">MDTRPVRLLVVDDEPHIADLVATVARYEGWQAVTAGSGEGALRTATEFKPDIVVLDLMLPDIDGFAVLDRLREVGQVPVVFLTARDGTADRVAGLTRGGDDYLVKPFSVEELMARLRAVLRRSTGPTWQRSVLQVSDLVLDEDTREVRRAGRLVPLTPTEYELLRYLMRRSPAVLTKPQILDHVWEYDFGGRSNVVELVISHLRRKLDDGAEPLIHTVRGVGYALRRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R6</accession>
    <name>A0A7W7T9R6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30200" checksum="DD7966EFD5E63EBD" modified="2021-06-02" version="1">MNPVAYAFRLGVDRGRREWLQSLRSSDQWFNFFMASVFAIVLLFQRTSTLAGTPLSLAAATLPSMIAMGVALGGLVGPAGQLSMNREDGTLLRAKAVPQGMLGYLVGRVTQTSLDTATGILIMVLPGIIVVPEIRAVGLGAWLTLIPVILLGLLATLPWGAVVGSIAKSPQGAMGYTMLPMLALVGISGIFYPITAMPEWVQGLAQVFPLYWLGLGMRSTILPDAAAAAEIAGSWRHLETLGVLGLWAVVGFALAPGILRRMARRESGANMEERRQAAIQRGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T1</accession>
    <name>A0A7W7T9T1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="39007" checksum="60215F6D6E992B65" modified="2021-06-02" version="1">MIPITVVDVKDAEALVLEVLRSGVIAQGPMVKRFEDAFAAIAGVPHAVAVNNGTTALVASIQALDLKPGDEVITSPFTFVATLNAILEAGATARFADIRADDFCIDADAVSAQVTDRTKVLMPVHLYGQTADMGKLVPLAERHGLAIVEDAAQAVGATFEGRPAGSFGTGCFSLYATKNVTTAEGGVITTSDDALADKLRVMRNQGMRARYQYEMAGHNYRLTDLHAAVGIPQLEKLAELTEARQRNAEALTKGLSELPGLTVPTVLPGRTHVWHQYTVLVGDDAPVTREELSAKLTEKGIGNGIYYPKLVFDYDCYRDNPQVVASDVPVAAKVAEQALSLPVHPKLTEAELERIVAAVREVFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V2</accession>
    <name>A0A7W7T9V2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="4">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="4">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="4">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">msrA</name>
        <name evidence="6" type="ORF">F4559_006582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23874" checksum="A457F33CFDEDACDB" modified="2021-06-02" version="1">MGWLGRDKTRLVTPDEALPGRTRPAEVPETHAVFPDRRIVPPFPEGLSTAVVGMGCFWGAERAFWRTEGVYSTAVGYAGGFTENPTYEEVCSGLTGHTEAVLVVFDPRKLPYDEVLRVFWQAHDPTQGMRQGNDVGTQYRSAVYWADEAQRTVAEASAKVYQEALTAAGLGTITTELAALGPFYYAEDYHQQYLEKVPNGYCGIGGTGVGCPVGLGVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9X4</accession>
    <name>A0A7W7T9X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation/acetate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="528" mass="54379" checksum="D0AFC0BE8755D985" modified="2021-06-02" version="1">MNDKALLNIGIFAIFVVATLVVVIRASRNNKTAADYLAAGHAFTGPQNGIAIAGDYLSAASFLGIAGAIAVNGYDGFLYSIGFLVAWLVALLLVAELLRNTGKYTMGDVLSFRMRQRPVRAAAATSTMVVSFFYLLAQMAGAGGLVALLLGVTDKAGQAVVIAVVGALMIAYVLIGGMKGTTWVQIIKAALLIVGAGIMTLWVLGKFGFNLSGLLGAAVENAPKAGEKLLGPGLQYGATATTKLDFLSLGLALVLGTAGLPHILMRFYTVPTAKEARRSVVWAIWLIGIFYLFTLVLGYGAAALVGPAKITGAPGGVNSAAPLLAEALGGPLLLGLIAAVAFATILAVVAGLTITASASFAHDIYVNIIKKGAAEGRAAEVKVARITAVVIGIVSILGGIAANGQNVAFLVALAFAVAASANLPTILYSLFWKRFNTSGALWSIYGGLTVAIVLIVLSPAVSGQPKAMFPSADFDLFPLSNPGIVSIPVAFVLGYLGTVLSKERNADKYAEMEVRALTGTGAEKAVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA20</accession>
    <name>A0A7W7TA20_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">F4559_006650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="120"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24454" checksum="E1DAFD970FDE84C8" modified="2021-06-02" version="1">MTADLEARVEEVFGDHADRAVAFTAMLTEHGVERGLIGPREVDRLWDRHVLNSAVVSVLFPENSRVVDVGSGAGLPGIPLAIARPDLDLTLLEPMERRVAWLTEVVETLGLNVTVVRGRAEEGPVRRRLADADAVTARAVAPLERLARWCLPLVRPGGRLVALKGESAADEVERDAEAVRKIGGTDIRVTTVGGDVLDVPTTVVLVQRAERASRRDGAQRSRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA35</accession>
    <name>A0A7W7TA35_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031513370" evidence="2">
        <location>
            <begin position="37"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="25820" checksum="775C526D4420D2F5" modified="2021-06-02" version="1">MSAVDRHTGASRIRRLLTRALLVAGGTLAGTTAAWALSDASASALPLDQDLVPVVGEAPTLESVDLTPVGDAVRALDSVVQVPDAPAPKLDRVAEQVRDTVTTWLVPHEAVAPVVDTFKVAVPSAPSRVDSRPTATAVPVEEAGTPEAHEADHAVAPTVPSTRSFAAGSEAAAVEASAASASAPTYPAGLPSKPFSPPAGVPVHCTCGGDGSGNSYQGNALSSGAFAFSGDESAMTGAALPAGRRPAVSPGKQPGVTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA48</accession>
    <name>A0A7W7TA48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA (Guanosine2251-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.185</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.185" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="32377" checksum="32D2EC7BB16A6CB8" modified="2021-06-02" version="1">MRNPGSKKGAVVGSGGQKSKGLQGKGPTPKASDRPNHPAYRRAQAGAKAEQARTQRRKAAENGPETVAGRNPVVECLRAEIPATALYVALGIDADDRVAEAVQLAAGRGISVLEVQRGELDRITGGAMHQGLGLQVPPYEYAEPRDLLRIAQQSGAHPLLVALDGVTDPRNLGAVVRSAAAFGAHGVVLPQRRSASVTAVAWRTSAGTAARVPIAIATNLTRQLREWAEAGLMIVGLDADGSVDIDGLDLATGPLVVVVGSEGRGLSRLVRETCDQTVSIPMASGVESLNASVAAGVVLAEVARRRRLDARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA70</accession>
    <name>A0A7W7TA70_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding FadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21925" checksum="362DA45319F8EA3F" modified="2021-06-02" version="1">MGDWTGLRGDIDRSSTAERVAAALRAKILAGDIGAGRQLNEKALGEALTVSRNTLREAFRLLTHERLLVHSYSRGVFVRKPDERDVHDLITARQVIELGALHHHATADDAARQALRDADAHDLLHRRLVALTGSTRLVAESDRLLAEQRLVLRGGVPPEVHDLAALLDRADLREAERRLTGYFDLCRESGLRAVGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB0</accession>
    <name>A0A7W7TAB0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide isomerase/thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="608" mass="65337" checksum="FCD1D445736EA1A5" modified="2021-06-02" version="1">MTTPRRRARVRAPELVGRGWLNTGDQQLRLADLRGKVVLLDFWTFCCINCLHVLDELRPLEAEFADVLVTVGVHSPKFVHEADPDALKAAVERYGVHHPVLDDPDLTTWTNYAVKAWPTLVLVDPEGYVVHVASGEGHHDALRQVITELIAEHEAKGTVHRGDGPYVAPVDEHTELRFPAKAVRAGDTLLVSDSAHHAVVELDLDGETVLRRFGTGARGRTDGTAPTFSEPAGLALLPDDVARRVGYHVVVADTVNHLLRGLNLDTGEVSTVAGTGEQWRDGETDGPADKIPLTSPWDVAWWEPAGGVAIALAGNHTLGLFKPEDHRLERLAGTTVEGLHDGPALDSFFAQTSGLAADGDRLWLVDSETSALRWLDADRTVHTAVGKGLFHFGHHDGPADEALFQHPLGVTVLPDHTVAVSDTYNGAIRRYDPETGEVSTLATDIAEPSDAVVVDGELVVVASAAHRLERPVAPGARLVSGRAHEVRRPPSEIAPGEFELVVVFTPPTGQKLDDRYGPSTRLEITSSPPGLIVEGAGVGTDLVRTLRIADGVTEGVLHVVAQAASCTDDPAVEHPVCKLTRQDWGVPVIVRSAAPHRLPLMMGGLDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB72</accession>
    <name>A0A7W7TB72_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.267</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.267" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:ribosomal protein S5-alanine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23907" checksum="766F5598AA0B5978" modified="2021-06-02" version="1">MSAGLAWDGGRHPGWPARLGPLRVAAGLVAVRPPRLFDASAWSRLRLRDQEYLEEWEPTAVGGWAERNAALSWPGQWSSLKALARRGQALPFVVTVDGELAGQVTVGNIVRGSLRSAWVGYWVAADRAGGGVATAALAAVVDHCFGYAGLHRLEATVRPENAASLRVLAKAGFREEGLFRRYLDVAGDWRDHLCYAMTAEETFPEGLVRRLVAQGYVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB91</accession>
    <name>A0A7W7TB91_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12179" checksum="3D89B16361B59100" modified="2021-06-02" version="1">MIYLHSTAAWRVDALVGVGLAASSSLTRDETDVDLFTDPRVVEVRVSDLVLDLAASVHGVDPSGAVHLATALLLGPSVTGFACADHHLRAAARANGLRAIGIPHLSLVFESRQTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTC5</accession>
    <name>A0A7W7WTC5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RsdA_SigD_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031928">
        <property type="entry name" value="RsdA_SigD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16751">
        <property type="entry name" value="RsdA_SigD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RsdA_SigD_bd" evidence="3">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="30170" checksum="258CA235A74D97B0" modified="2021-06-02" version="1">MVDQHGKGNGKVVRGQDERTPLTPEDEPGDDLAGIRADDALLDALGGRVGDQDESLVDDELNALLLAWRREVHSKPVGELVDVDTAAATIAAARPQQRGRHRFLIPLASAAAILAIAFTGVSLVARDALPGDTLWGLTKVLYSEHARSVEAAVAVRTDLDTARAALRDGRVDEARDLLDKAGASLPSISADDGKADLTQTHTSLMQELTSTPAPTSTPSTPPPAPSTTLTTTPPKVEPQPTTIEPTVPQSTTPPTTTNETTVPALPSGTQSENGARNEIVPEQSSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTE3</accession>
    <name>A0A7W7WTE3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propionyl-CoA carboxylase beta chain</fullName>
            <ecNumber evidence="3">6.4.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="279"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="533" mass="57230" checksum="46333D955D5EE305" modified="2021-06-02" version="1">MTDDGTVPDVHTTAGKLTDLRRRDEEAVHAGSARMVEKQHAKGKLTARERIDLLLDPGSFVELDALARHRSTNFGQDRNRPYGDGVVTGYGTVDGRPVCVFSQDVTVFGGSLGEVYGEKIVKVMDLAVKTGRPIVGINEGGGARIQEGVVSLGLYGEIFRRNVAASGVVPQISLIMGANAGGHVYSPALTDFVVMVDRTSHMFITGPDVIKTVTGEDVGFEELGGGRTHNTRSGNAHHLAADEEEAILYVKDLLAHLPANNLSEPPVFDSAGYADEVTDVDLELDTLVPDSANRPYDMHEVITRVLDDGEFLEIQSLFAPNILVGFGRVDGHSVGVVANQPTQFAGCLDIDASEKAARFVRTCDAFNVPVLTFVDVPGFLPGTDQEWNGIIRRGAKLIYAYAEATVPLVTVITRKAYGGAYDVMGSKHLGADVNLAWPTAQIAVMGAQGAANIVHRKTLAAAAESGEDVDALRGRLQQEYEDALCNPYVAAERGYVDAVIAPSQTRVQVARALVLLREKRESLPPKKHGNIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI5</accession>
    <name>A0A7W7WTI5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="7" type="ORF">F4559_000498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="111"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="42696" checksum="AC2D37F38EE5C009" modified="2021-06-02" version="1">MDSRTRLPVVGMIGGGQLARMTHQAAIPLGQSLRVLAETDSDPAALVARDVEYGKHTDLDALRAFAKSCDVITFDHEHVPQEHLRELVAGGVKVHPGPDALVHAQDKLVMRVRLAELGLPVPPFAEVKSEADAVAFGAEHGWPCVLKAIRGGYDGRGVWMLNTPQSAHRVVAELLEAGTPLMVEQCVPMRRELAALVARSPFGQGAAWPVVQTVQQDGICVEVLAPAPDVDGEEAQELALRIAHELGVVGLLAVELFETDGGLVINELAMRPHNSGHWTIEGARTSQFEQHVRAVLDYPLGSTDLAAPAVVMANVLGAAEPPAMGPDERLHHLFARFPDVHVHLYGKAERPGRKIGHVTMLGERPADVRERARLAAHWLSTGVWQDGYDIHGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI8</accession>
    <name>A0A7W7WTI8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage repressor protein C with HTH and peptisase S24 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="1">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11394" checksum="594B2379BDFCDE75" modified="2021-06-02" version="1">MARNPLPLVRVVGPSMAPTLRTGDLVIVRFGAPPTTQDVVLVRWDGRPGQLSVKRALRETGGGWHVEGDNPFASTDSRTLGAAHVLGVVLFRLWPRPGRLPARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT6</accession>
    <name>A0A7W7WTT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20216" checksum="F936DAD1F6601BEB" modified="2021-06-02" version="1">MNDRDDHLSVSQAGSSVVLRLRPWRSDDLPALVAAHRDPQLRRWLANSLADEAEARRWLDAQAGGWDSATRFSFAVVADENDQAPVGHVVVKVGTAGVAEVGYWTVARARGRGIASRSLETVSQWALSAQNLVRLNRLDLLHAEANQASCRVAEKCGYILHDLLPAAPPTFSARGHRHVRTQPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU16</accession>
    <name>A0A7W7WU16_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-methylcrotonyl-CoA carboxylase beta subunit</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="277"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="533" mass="57379" checksum="27617182182E5198" modified="2021-06-02" version="1">MDAPVLRSVADKSSDAFRRNTEDHTALVDDLREKLAAASRGGPEKARTRHVDRGKLLPRDRVDTLLDPGSPFLELSPLAADGLYGGEAPAAGVITGVGRVSGREVVVVANDATVKGGTYYPMTVKKHLRAQEVALHNHLPCVYLVDSGGAFLPRQDEVFPDRDHFGRIFFNQATMSARGIPQIAAVLGSCTAGGAYVPAMSDEAVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDLHSRTSGVTDHLADDDAHALRIVRSIVSTLGPRGPRPWQVEPSVEPVVDPGELYGVVPTDSRTPYDVREVIARVVDGSRFHEFKKDYGHTLVTGFARIHGHPVGIVANNGVLFGESALKGAHFIQLCDQRGVPLVFLQNISGFMVGREYEAGGIAKHGAKMVTAVACARVPKFTVVIGGSFGAGNYSMCGRAYSPRFLWMWPNARISVMGGEQAASVLATVRRDQLDSWSEEDEEAFKAPIRRQYEDQGNPYYSTARLWDDGVIDPRDTRTVLGLALSVSANAPIEPVSYGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU66</accession>
    <name>A0A7W7WU66_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40188" checksum="8DD77BD956BAC2BB" modified="2021-06-02" version="1">MSPVEPSVLIDATAVPADRGGVGRYVDSLVAALDADGARLSVVCQTRDADLYTRLAPHSRVVPAAEAVAARTARLTWEQASLPRLAARLGVDVVHSPHYTMPLAGRVPSVVTLHDATFFTDAVLHSSVKARFFRAWTRASLKRAALCIVPSRATADELTRVAGADRRLLHVAQHGVDTDRFHPPTPVETATVRRLLSLGTAPYVAFLGALEPRKNVPALIRGFAQAVRDLSRPPALVLAGQPGWDGQVERALDAVPHRIRVIRAGYLPFEHLSGFLGGAELVAYPSLGEGFGLPVLEAMASGACVLTTRRLSLPEVGGDAVAYCGVGAGDIASALRDLLADPTRRDVLSSAAQVRAKSFSWSTSATLHRMAYATATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU77</accession>
    <name>A0A7W7WU77_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="17" type="ORF">F4559_000557</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="16">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="86"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="401"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="833"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="890"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4963198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="955" mass="106844" checksum="073D40E48FBC52BD" modified="2021-06-02" version="1">MVLSRLLRAGEGKMLKRLRNIAAHINHLEDEVVDLSDTELRAKTEEFKKRYAEGESLDELLPEAFAVVREGAKRTLGQRPFDVQLMGGAALHLGQIAEMRTGEGKTLTSVLPTYLNAIAGQGVHVITTNDYLAKRDAEWMGRIHRFLGLTVGAILSEMTPEQRRVAYQADITYGTNNEFGFDYLRDNMAWSLDECVQRGHFFGLVDEVDSILIDEARTPLIISGPADQSSRWYLEFARMAPRLKKDTHYEVDERKRTVGVTEAGVAYIEDQLGIDNLYEAANTPLVGYLNNALKAKELFTRDKDYIVRNGEVMIVDEFTGRVLAGRRYNEGMHQAIEAKEGVEIKAENQTLATITLQNYFRLYKKLGGMTGTAETEAAEFHQTYKLGVVPIPTNRPMQRKDESDLVYKTEEAKFDAVAEDIAERHEKGQPVLIGTTSVERSEYLSKLLVRKGIPHEVLNAKHHDREALIIAKAGRKGAVTVATNMAGRGTDIVLGGNPDIIADHELRERGLDPVESPEEYEQAWSKVIEDITAEVKAEAEEVREAGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLKDELMRRFNAAMVETVMTRLKVPDEVPIEHKMVTRAIRSAQTQVEQQNFEIRKNVLKYDEVMNEQRKVIYAERHRVLDGEDLREQVEHMITSVVSDYVDGATADGYAEDWDFDKLWTALKTLYPVSLDYEALLESDDDVTKEFLKEKLQEDAMNAYAAREADIDGRVGPGAIRELERRVLLSVLDRKWREHLYEMDYLKEGIGLRAMAQRDPLIEYQREGFEMFNAMLDALREETVGFLFNLQVEAAEPEPAPEPPVQVSIANGAGPLTGSRARARAAAAAQQEERGRDQAPAGPAMAQLEGNAIPPALRGKGLGNQGGQQRLSYSGPSESGDAETSSDKPAGGQGGQGGTRKERRAQARAQAKGNRKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU79</accession>
    <name>A0A7W7WU79_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division septum initiation protein DivIVA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26922" checksum="CDD7A3FFD4CF75A0" modified="2021-06-02" version="1">MATTGEGSDVYRVFEALDELVTIVEEARGVPMTSGCVVPRGDVLELLDDVRDAIPGELDDAQDVLDHRDELIGKAQHELDTATSKARSDADRIVGEAQHEAERMLSEARARAERMVAEAEDQAQRTVVTGRQEYEDLVGRAHAEADRMIQAGRAGYERAIEEGRAEQSRLVDQTEVVRAAHAESARVVESAQTESMRLRGECDAYVDGKLADFEDLLAHTLRSVGKGRSHLRGPAVAGAAPFDYHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA1</accession>
    <name>A0A7W7WUA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31724" checksum="2607D8388B6AC4CC" modified="2021-06-02" version="1">MEQLTVDELAVRVGLPGSTIRMYQTKGVLHPPRRQGRVAYYDGTHIERLTLVQRLQSRGFSLPAIAELIAARERGATVASVLGVGDAEGPDDWVRIRVRDLRRLVGLGDLHPRLIKRAVDLGLIRWRRGWPHARRWALEAGNRLAALAVPSDDVLDNFSRLRAATDAIAADFVEVFERRVWPQLAEATDQEDQLDRIRALLVELTYTAETVVIGTLREAVRDAAEEFAGRNGLLPSGGFQPAWADEPVPIAERITETETETPDEPEIQRFLDRGDDHDERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA5</accession>
    <name>A0A7W7WUA5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase-like lactoylglutathione lyase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12398" checksum="8112D39B4C564BBB" modified="2021-06-02" version="1">MTLHIGMVTIDTTDLRPLVDFWTKALGTTVENDWGEFVVLAPAVEGGVRLGIQRVPEAVGGKNRVHFDSHVADRVAEVARLVSLGATEVAEHAVPGLKWTVLADPDGNQFCVGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM6</accession>
    <name>A0A7W7WUM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in multi-copper enzyme maturation permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="23267" checksum="9238FDFBF7453E9B" modified="2021-06-02" version="1">MRWIVIAFVLPTVAIIVGLARTGGTALAQSTEVRLAASVLPAVVLMQIAVAIVSVVVTGSEYTHGVIRASLTMAPRRGLLLTAKYVAAAGFGFLVGLVTAAIAIAITAVFSDRGGEWNAVLMRAGFGAGAYLAVLAVLAAALTVLVRGTATAVLIVIAVVYVVPLIAVPLIPGLTGTVGEFWPTTIGLTLVAPPGVGTVPPAAGFLVFVAECAIPVILSWLLFDRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUZ6</accession>
    <name>A0A7W7WUZ6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="7" type="ORF">F4559_001337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051921">
        <property type="term" value="F:adenosylcobyric acid synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="5"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="259"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="507" mass="53275" checksum="8B3C13CA7FA20B93" modified="2021-06-02" version="1">MGGGLLVAGTTSDAGKSVLVAGLCRWLARRGVRVAPFKAQNMSNNSVVTPDGGEIGRAQAFQAAACGLEPSVRFNPVLLKPGGDRSSQVVVLGRAVGEVSALSYRERKAELFDTVLDTLRSLRRDHDVVVCEGAGSPAEINLRATDIANMGLARAADLPVLVVGDIDRGGIFAHLFGTLALLDPADQALVAGFVVNKFRGDPALLEPGLRQLTALTGRPVHGVLPWREELWLDAEDSLSYAADGVVGRPAPPVGDQWLRVAVVRLPRISNATDVEALACEPGVSVRFVTEPSRLADADLVVVPGSKATVADLAWLRSTGLADAIATHPGPVFGVCGGFQMLAARVEDDVESRAGAVPGLGLLDLDVRFAPDKTLRRPTGIAFGYAVGGYEIHHGQVVRNGEDGLLTLADGTPEGAVRDRVAGTHWHGLLENDDFRRAFLRWAAARAGRDGFVPAADVDFAGRRAAQFDLLGDLVAEHLDTDAVLRLLEEGPPPGLPVIPPAGAPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV05</accession>
    <name>A0A7W7WV05_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031323731" evidence="3">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="26238" checksum="4CF8ADA38DC6EF60" modified="2021-06-02" version="1">MSGTRLVGVLLLLAAAVTAALATFLPLFRYVQEFSPSNGIEFSSTSWEYEVRFKISADDAEGVDRSSDDQREPSPQFGVPVMFGVLVLFGAALLSFLPERQRLASRYAAVGASGVLIGGVGAAFAFAAKALTSGDPVRAQVQDGHYGAGLWLLLAATAAAVVGTVLLHTRRERAVEATVGVVYRVDEGDDDTPPFGIPVAVLPGDAVTGGPVRDTGPASGAGASTAAGVVGTESAGVGTVADGNPAGNADGKSEERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV24</accession>
    <name>A0A7W7WV24_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_001427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="12">
        <location>
            <begin position="386"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4964068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="744" mass="80042" checksum="AC5787C0D7E937B9" modified="2021-06-02" version="1">MRTVGRSKDLDPEHRRDGLALVLIALAVITAAGVWWQAGGPVGRWVDVAVRSSVGTPALIVPLVLLAIGVTLMRTDPNPEARPRLVIGSALVAVGFLGMFHLIGGLPSEPVARRTAGGALGYLSGGFLAQGLTTWVAGPLLVLIFAYGVLVLTHVPVREVPARLAGLLNGRRSDTLPDFGDEPPFDEDEPKPKRRSRRAVVVEEQPELPLDEEPPVDDVPPPRTRSPKVKPTPPAEEPPRHDIAVRAVEGDYKLPPPTVLKMGDAPKLRSKANDVMIEAITGVLDQFSVDARVTGFTRGPTVTRYEVELGHGVKVEKITALTKNIAYAVATDNVRLLAPIPGKSAVGIEVPNSDREMVRLGDVLRSPGTVGDSHPMVIGLGKDIEGHFVTANLTKMPHLLVAGSTGSGKSSFVNSMLVSLLARATPDEVRMILIDPKMVELTPYEGIPHLITPIITQPKKAAAALAWLVEEMEQRYQDMQVNRVRHIDDFNRKVRTGEISAPPGSERVYRPYPYIMAIVDELADLMMTAPRDVEDAIVRITQKARAAGIHLVLATQRPSVDVVTGLIKTNVPSRLAFATSSLTDSRVILDQPGAEKLIGMGDGLYLPMGASKPVRVQGAFVGDEEISQIVEFTKSQATPEYTDGVTAAKAGEKKEIDADIGDDLEVLLQAAELIVTSQFGSTSMLQRKLRVGFAKAGRLMDLLETRGVVGPSEGSKAREVLIKPDELDSVVHLIRGGGPVPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV52</accession>
    <name>A0A7W7WV52_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="17970" checksum="D192740C730A2E85" modified="2021-06-02" version="1">MTSADRAGVDDPGLGRRLGVDVGSVRVGVALSDPGAVLATPLVTLSRDEAHGRDLADLAGLVAEHDIVEVVVGLPRTLAGRHGPAAELATAYAAELRRRVEPVPVRLTDERLTTVTASRVLSDRGVKGRKQRAVVDQAAAVEILQTWLDGRARHVARAEQEGRAPGDGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV55</accession>
    <name>A0A7W7WV55_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase (TIGR01549 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23529" checksum="203F4B2E4064C64C" modified="2021-06-02" version="1">MTNTLVLDVDGTLVDTNYHHAIAWFRAFRRHGLTVPTWKLHRAIGMGGDKLVAEIAGQHVEDEHGDDVRAAWEAEFEPMLDEVRPFEGAHRLITTALEKDFAVVLASSGKRRHVDHYVKLLDVPDVASTSSDDVDESKPAPDLIATALDRVEGGRAVVVGDSVWDCEAARRAGLPCVALRTGGFAEADLLDHGASAVYDELDRLRADLSDLPFGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI4</accession>
    <name>A0A7W7WVI4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase (APT) family kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="40"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="34158" checksum="792FE8EC85942CE0" modified="2021-06-02" version="1">MALPTRQDDSGLPGLPALREACRIFGADPAEARPLHRRSNAVYLLPRDHLVARLAPDTPVRRRRARISVEVTRWLDTQPEPIALAPMPGEQPVVAAGAVATFWPHRPTTPAPSPADLAVPLRRLHTLPAPPFPIPRYTPLQRLFEAVDLDRDRARPVVADDDRAWLLDRAHALVDIFTTTSFPLGEGLVHADAHSENLVRDADHGHWLLIDWDNACLGPRELDLLTGIPDHFHDPEAERTRFLAAYGRNILDWPRWTLLRDITELRALGAYIRLAPGKPAAAAELRHRIRSLRTGDRSARWSAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW39</accession>
    <name>A0A7W7WW39_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ORF">F4559_003334</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4965975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="18700" checksum="74053633F0D2CB1F" modified="2021-06-02" version="1">MLKQTVAGLRVLLVLTVLTGVLYPLAVWGASRLPGLRDRAEAVDTTLVAVDREGDEWFHPRPSAAVPPASGGSNKGEHNAEYTAVIADRRAAVARREGVPPDRVPLDAVTASASGLDPHISVEYALLQVPRVARANGLDERRVREWVAGCTEGRVAGFLGEPGVNVTALNRALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW59</accession>
    <name>A0A7W7WW59_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8725" checksum="D3D77A8948B23E46" modified="2021-06-02" version="1">MDAILDTVDNGIKWRALTADFPPWNTVYRRFAAWEPGGAAERLLNAVRDRARLKAGHVAAPRQRRTGDVTIRVRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV9</accession>
    <name>A0A7W7WWV9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32337" checksum="73F22C79CE4416AF" modified="2021-06-02" version="1">MNRRSTLAFWLFVGPFAVGLLLFTYLPIGWSAYLSLFDARNTVTPTSFVGLENYAAVLSDRAFLDSIGTFTVFAAFVIPLTMALSLGLALLVDRVKVARAFFRSVFFLPFACSYVVAALVWKMALFSGVDSGVANTVLGWFGVAPVAWVGQVDPPLYWVVLVTVRLWLQLGFFMILLLAALQRIPKHLYEAAWTDGASPWQTFRHVTLPGLRGALVAVFTLNLINAYQAFDEFYNVLGDSRGYPPFARPPLVYLYYNSLGSGAQDLGRGSAGAVVLAGVIALVTLLSGRVLRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX24</accession>
    <name>A0A7W7WX24_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="36568" checksum="0EB77B2CB86F4047" modified="2021-06-02" version="1">MSRLADHAAVSTALSLLGDNELRTLVDNAPVVHEGIGGTAVRLTVEGRDVFVKRVALTTLERQGRNVRSTANLFGLPPWFHYGLGSAGFGGWRELAAHVMATDWVIAGRTAAFPLLHHWRALDQEPRAVDLAEVERTVAFWDGLPSVRHRVEALAVATSALVLFLEHFPYTLDEWAGRHGVGGFVEKDLLDGLDFLRGNGLWHFDTHLGNILTDGGRLYFCDFGLACSTRFALDPHEREFLDRNVAHDRDYAIRCLVDRVLRTACGDDRERADAVLRRCAETGDSPDLAGIPEADADVVRRHARTALRMKRFYHDLVVESRRTPYPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD9</accession>
    <name>A0A7W7WXD9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="442" mass="49050" checksum="057747227E0B5945" modified="2021-06-02" version="1">MTTTPACPVARGPRGLPVLGVAAEYFRDPAGYTLRLQEDHGGMVDVTLPKPFVQVTEPEAVDRVLRGNPDNCTRGELYKGFIGYMGRGLLTLDDPQWRPHRKVVQPAFSRTRITADAEEAVAATRVVLERWATRAGQVFDMAADVMAISTRTMGQALIGRDLSVPGLGYDRAAAIASKVMYTRTVFGVNELLPGFLNTRYQRERRWSHRVIDGVVHAAITSRRRSGVERGDALDHLLASDLDEQAIRDDLRTLLLAGTDTTGQALAWTLYELARHPAVRREVEDEVDRVLGDAAPTPATRDELVVTRSAVDEALRLHPPVWQFPRDLIEDDVLAGRSVPGGSTVLLSTYGTHRSAEHWTDPEAFDPSRFRDGSTRHRQAYFPFGGGRRMCIGRDLALATLVTAVAMTTRRFRLTLSSRPVRVGTYITMFPSDGIHVTARERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXS3</accession>
    <name>A0A7W7WXS3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6260" checksum="721F3573ED13B655" modified="2021-06-02" version="1">MTNPEVDSLAELIDDCTDLPRELRTAGKTIPAPRAAEPWQVDEDTYRQVEGLDAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU9</accession>
    <name>A0A7W7WYU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030577485" evidence="1">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="20574" checksum="41129538FD4C66BC" modified="2021-06-02" version="1">MKLRIAAACAVAALSLVGCSQNASTGSGSSSAAGTSSATAAATSSASSAASGAKTTEWAGAFCTGIGPVMVSTLQLLKDTFTLEGAAKRDAHLKYIDTVSPLLNDTAAKLKTIGPPTPETATEHQAVIDAMTGMAEGAAKARPAIVALDPADPAMNDKLADTLTQYGDMDKLGTQLDTVDKLPGLKEAFEQTPACVEAKASIAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV1</accession>
    <name>A0A7W7WYV1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated rhomboid family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="52"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="20630" checksum="DC571F5F5C4A43DD" modified="2021-06-02" version="1">MNAVRRIFPPRPLSAALVVSSFVGLLYVIEAIDTALGGALDDDGVIPRDFSQWDNILWYPLLHAGWAHLTGNAVPLLLLGFLACSGGLKQFFQVTVVIWLTGGLGVWLFGAYASHIGASVLIFGYLTFLLVRALFARSAAQIAVAVVVFALYGAALWGVLPGQPGVSWEGHLFGALGGVLAAWGVARDSRAEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYZ7</accession>
    <name>A0A7W7WYZ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
            <ecNumber evidence="4">2.5.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102028">
        <property type="term" value="F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="39850" checksum="7F37A69E87E52A35" modified="2021-06-02" version="1">MDQYGFATKAIHAGQEPDPTTGSVIVPIHATSTYAQDGVGGLRDGFEYSRTGNPTRAALEECLAALEGGTHGRAFASGMGATDTALRALCRPGDHVIIPNDAYGGTFRLIDKVFSHWGLTHTPVPLSDVDAVRAAIRPETKVVWVETPTNPLLNIADIAALAEIAHAAGAKLVVDNTFASPYLQTPLALGADVVLHSTTKYVGGHSDVIGGALVTSDAELDAAFGFLQNGAGAVPGPFDAWLTLRGIKTLALRMEKHSDNAELVAAALLDHPKVTRVYYPGLPEHPGHDVAARQMRRFGGMISFSVDGGEDAALKVCARTRLFTLAESLGGVESLIEHPGRMTHASTAGSLLQVPADLIRISVGIESGDDLVADLLTALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ02</accession>
    <name>A0A7W7WZ02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transitional endoplasmic reticulum ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="4">
        <location>
            <begin position="102"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="358"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="613"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="840" mass="84303" checksum="348CCA3C448426E8" modified="2021-06-02" version="1">MITLTTRLSPSALDTRRGVVRLHPEVLDALGLRAWDAVRLTGARVSAALAAAGDGPPGVVLVDDVTLSNLGIVEGSEVVVAPTVVTAARAVTVAGSRLAATSLTPETLRMALTGKVLTVGDAVSLLPQDLAPPPGADVGATRSRLSNAIGMTWTNELVTITAVDPAGPVAVQPSTVVGWRDGPRTGAGPVSTPAPGGVLGPVRGRGDGALGSGLAALGSGGPGPIALGSAGSGSAGSGSAGSGSAGSGSAGSGRGGLGAGGSGADGSGASGGGAAGFGGARDGLGQGSLGQDGVAGVAGADGGRFARNAGFVGNADSGVVEPGVGDLVGQRDAIRRLGEWFDLSFTHPELLARLGAAPGIAALVSGPEGVGKATLVRAVAREAGAAVVEVASPGIAVLEANATAARLAEAIDAAHAVGGPVVLLLTDVEALLPAASPPPVATIVLDALRTAVSASCALVVTSAHPESIDPRLRVPDLVDREIVLPLPDGAQRTELLRVLFRDVPIDSEVDFGAIADRTPGFVAADLIALRRESAVQAALRQRKAEEPQVAQEDLLGALDTVRPISMSTSDTLRTGGLTLDDVGDMVEVKQALTEAALWPLQYPDSFARLGVAPPRGLLMYGPPGCGKTFLVRALAGSGRLNVLSVKGAELMDKFVGESERAVRELFRRAAEAAPALVFLDEVDALAPRRGQSSDSGVADRVVAALLTELDGVEPLRDVVVLGATNRPELVDPALLRPGRLERLVYVPPPDADARTAILRAAARNTPLADVDLGALAADLDGYSAADCAALIREAALTAMRESLEATVVTADHLAAARAVVRPSLDPAQLASLAAYAESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ08</accession>
    <name>A0A7W7WZ08_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fur family ferric uptake transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15462" checksum="26F1B3CBF1A3BEE8" modified="2021-06-02" version="1">MTPGSRELLKGVGLRVTAPRLAVLDWLAGHPHATADQVAGGIRERLGSVSTQAVYDVLNACERTGLLRRIEPAGHPARYETRTGDNHHHLVCRTCGRTEDVDCVHGAAPCLEPSDVAGFALDEAEILFWGQCPDCRTAEERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ43</accession>
    <name>A0A7W7WZ43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="41666" checksum="E2ACB75A297AAC04" modified="2021-06-02" version="1">MSPIPALRDADEAASVARIEADLARGRWCAALDRAFRLPGLPVRDAHDPARRLAVVARTLARAGRASAARHFADLARRALPKAGGETATRIALSLDPLPPNAPPRTATPLPADRPRTTRMPPIGTDTAKALGRAEEALTWLDHAATRSAHAADWARLMRWCEARDSARLDGVHAALLELIHHALPRPRNRPVHTDRALVPYLDHDHAPTAATPRPVDLAEIAVRHLSPAATHHAHRMALAGDVSRLLSGPWLPFAGGLVARRHQADASDAEHFVRLVADATTAACHAAVTTLHDLERLHGRLATLLPFGRLSRLALRDLFTRGLITAPDLARRHPMSAKTAVNILGRFLDRGLVVPYNHHGYARCFYNPDLVDLLTRTPKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ86</accession>
    <name>A0A7W7WZ86_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="32504" checksum="C473A0D4FA0A60B5" modified="2021-06-02" version="1">MSDQFAALSTVEQPDTGRTRGLFGDAWYALRHRPLFWVSVAIIAFVLLMALFPGLFTSADPTLAMLSRSRQAPSSAAWFGYDNQGYDIYARVVYGARASIVVGLMAMAGAVLLGAAVGMMCGFYGGWLDVVLSRIADIFVGIPFVLGAIVILTTLNAGGDAGAARIVAQVVLSLVVLSWPVSMRIMRSTAIAAKQQDYVKAARALGAGPRRIIVKHLLPNCVAPVLVYSTIVLGAFIGLEATLSYLGIGLRPPVVSWGVMINSAKDYLRVAPHALLFPSAFLTATVLAFVMLGDAVREALDPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA0</accession>
    <name>A0A7W7WZA0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">F4559_006708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="14729" checksum="24AAF1D85139AE66" modified="2021-06-02" version="1">MSGLGGPGDIVEVKDGYGRNYLLPRGLAILATKGAAKQVEVIRRAQETRRIRDLDHAKEVKASLEGLGAVTLKAKAAAGSKKLFGSVTSSDVVSAVRAAGGPSLDKRAVELAGHIKTLGKHSVSVRLHPEVTVALAVEVSAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXS8</accession>
    <name>A0A7W7SXS8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">F4559_000223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4962864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="25394" checksum="307CAACE4E9FF929" modified="2021-06-02" version="1">MKRSKAYKNAAELVDRERLYSPLEAAKLAKDTSKVKLDATVEVAIRLGVDPRKADQMVRGTVNLPHGTGKTARVIVFATGDKAAEAEAAGADAVGSEDLIERIQGGWLDFDAAIATPDQMAKVGRIARILGPRGLMPNPKTGTVTPEVSKAVTDIKGGKINFRVDKQANLHLVIGKVSFDAEKLVENYAAALDEILRAKPSAAKGRYLKKVTVSTTMGPGIPVDPNRTRNLLADEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXV8</accession>
    <name>A0A7W7SXV8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="46893" checksum="9A80AFBCC6D70C2A" modified="2021-06-02" version="1">MTTPAVDRLSGRDWRLLLVLCGAIFLEGVDISMTAVALPAIREDLDLAPTALQWVVSAYVLGYGGFMLLGGRAADRFGRRRVFLFWLAVFVVFSGLGGFAQDGVVLVVARFVTGLSAAFLTPTGLSIITTTFTGPRRDRALIVYGATGAAGFSLGMVVGGLLTGFGWRWVFFAPVVLAALILVVAIKALPRAERRTPGRFDVVGAVIVTAAMVLLVYGVAEGPSLTAVLGGLVLLGVFAVVERRVPDPLVRFATLRAKASVDIAALLYAASFFGFQFILVLFLQDELGWTPWQTGLALLIMGIDAVLAPTLTPRLVRRFGLTRVTVAGLASGTLAYALVLRADTDWTYWDVLPSAVLVGIAFALAYGPLTIAATDGVPDAEQGLAGGLLNTAFQFGAALGVAGVTAVSAFGTTRLDGYRLAVLLSIGAAVAAAVLVATGGTGRRTAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYJ6</accession>
    <name>A0A7W7SYJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="25495" checksum="61EF5084025E3A00" modified="2021-06-02" version="1">MAYQPSSWAVSQFGDQTHAVVHSLVRGLNRAQRARWLVQRDAHAQGVLTKRAYGSLWDTPYHSVIEELGLENLDGYRVHHPYGASYDLAMVGGRVLVPFKLGSRMPLSPKVVTIATLVPQRTGRRFGVEPPAMLFDLHAPARPTVADAVAAAGEADLTVIYVGFVANADSDRVLGAWWGEPISLADDGTLTWEPERLPLDLDLEDAPQLPLTGFAEGDEPELDVTRHPDARDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP3</accession>
    <name>A0A7W7SYP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="17"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="463" mass="46957" checksum="22B4090EF2F0F787" modified="2021-06-02" version="1">MNTGSWGALLRPPHLAVLTVLAGGTALHAINIYLVTAMLPSVVADIGGLRYYAWSTTLFMFASVVSSALVPRCLSRLGPRGSYRFAFVAFGIGTLVCALAPDMAVLLVGRTVQGLGGGLLVGLSYAMIGATLPPALWTRAAGVLSAMWGVGTLVGPALGGAFAQLGQWRTAFGVLAGCTLGLMLLLRSTMPDDRTRTATPVPVANLALIAAAVLLVSATSLSHEALVNVAGVVGAIVLLGVFVHRERTRAPRVLPRKAFTSGSALIPLYGTLVVLVLASTTEIFVPFFGGHLGGLGPLAAGFLGAALAAGWTVGSMVSAGLTGRARALVGVAPLVSALGLTGLSLTSWSAAPAALVLVWAVLLFVTGSGVGIAWPHMTATAMNSGDTPREQDTAAASLTTVQLVATSLGAALAGTVTNLTGVDGNAADIANSSRWLYGVFGAIVLTGVLFAHRTVSSRTTEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ68</accession>
    <name>A0A7W7SZ68_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14543" checksum="0D8D801390140F83" modified="2021-06-02" version="1">MTYREKAMIVALSTTTNEAALSGTPQEYAELAAALERGQGRFALVTTENIAPYGVALETLSVEAVDTPTVRITVDRTALDLAIRGPVRHLATLSRIVLAGADSGDPKGHVHLEGFEGHDFLAEDSFSLTVHDAVDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ91</accession>
    <name>A0A7W7SZ91_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">F4559_000939</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4963580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="19641" checksum="148FA9FD60214762" modified="2021-06-02" version="1">MNSLILAEGPVNPVVPHTVEIIVGLIAFLLLFFVIKKFVSPRFEALYEERTAKIEGGIAKAEQAQVEAQQALAQYRDQLAEARAEAARIRDDARIEGEAIIAELRAKAQEEAGRIVAQGQTQLETQRAQIVAELRGELGKLAVDLADRVVGESLEDEVRRRGTVDRFLAELDGASAPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA6</accession>
    <name>A0A7W7SZA6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031060675" evidence="2">
        <location>
            <begin position="30"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="17592" checksum="35C21088C267F66D" modified="2021-06-02" version="1">MRRVVFRMPMPALFAALTTAICATPVAWAAPGLQAIYLLPLGFGWWVVRNRTTVDEERLVARGTFGRRVIAWSEVSAIKVVARGWLSARLADGSLVRLPAVRAGHLPALSVVSGGRVPDPSAPEPDEAAPDETDATASDRVEDAAPAGTTPDSTTPDAPAGEKPTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZD0</accession>
    <name>A0A7W7SZD0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20654" checksum="B66988E3E745C4A4" modified="2021-06-02" version="1">MTVDAEWQNSWTAAVYLYRHLAAGGVPEPVACPLVLGQDEVAYADLAIGYARYYSMTVEYQQSSGFFFGSPLFVAAGLAANAIGNANARNRAAAQSAPQWREHCVARTVVTNQRTMCQIQGQWLSFWHGGVVEFTGDPAAGWCAMTFGDSEPLMLTGPTAPWLTVLLSYFVHGAQRFPQLPHLHRLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL8</accession>
    <name>A0A7W7SZL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="20221" checksum="BD43C59723EC4A2C" modified="2021-06-02" version="1">MVEKLGSRQVYANPWMTVREDDIRRADGTTGIYGVVDKPAYALVVPLDGERLRLVEQYRYPLGLRRWEFPQGTAPDRAEADPLELAARELREETGLRAGKLVELGNLDVAPGMSSQRGRVFLATELTEGDHEREQEEQDMRSAWFPRAEVEAMMARGEITDAQSIAAYTLLLLHEHAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ2</accession>
    <name>A0A7W7SZZ2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">F4559_001314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="27222" checksum="B972DA2C306CFD82" modified="2021-06-02" version="1">MSAEADHDPADGYRRVMLKLGGEMFGGGGVGVDPDVVQTVSRQIAAVVRTGVQIAVVIGGGNFFRGAELQQRGMDRSRADYMGMLGTVMNCLALQDFLEREHGIDTRVQTAITMGQVAEPYIPRRAMRHLEKGRVVIFGGGAGMPYFSTDTTAAQRALEIGCEIVLMAKAVDGIYTADPRIDPDAQMFDHITHREVLERGLNVADATAFSLCMDNLMPIMVFNLLTEGNIARAVRGEKIGTLVSTPGGRPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T055</accession>
    <name>A0A7W7T055_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13701" checksum="5AFAAA0AEA374746" modified="2021-06-02" version="1">MTLGREKYVLLTTYRKSGEGVPTPVWVGEEDGALYVWSTADAGKVKRIRRDGRVHIGPCDLRGRPTGDQVEAHAELLDAEGSEFSRRLIARKYGLLGRLTLLGSRLRRGRQGTIGIRVIPSTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0B2</accession>
    <name>A0A7W7T0B2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PurR-regulated permease PerM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8790" checksum="7D8B519315A8407D" modified="2021-06-02" version="1">MPSERAYRVPVRTILATIGLTLATVVARVSVTHVQRVLVWMLIAVVFTVALYPTVNWPQTVSAGTAARRRHWPCSSWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D2</accession>
    <name>A0A7W7T0D2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CBS domain containing-hemolysin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_001625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="36342" checksum="255E0D805D3FD9D8" modified="2021-06-02" version="1">MSPAWALVVSLVLLVANAFFVAAEFALIAARRHRLEHVDSRAARAAVAGIRELSLMLAGAQLGITLCTLGLGALAKPAVADLLDPLFAATGLPESAAYAIAFTLSLVVVVFLHMVVGEMAPKSWAITHPERSALLLAIPFRFFARSVRFVLGGLNRLTNALLRLVKVEPRDELAREHRPDDIRLLVRQSGEHGLIPEGQQRLLTRMLQLQRTTVEQIMVPIDRVVGVTGDATAADVEHRSRESGRSRFPVVDATGAYVGLVHVREAVRTPSGTARDLMSRPLVLSAATPVAGAVTEMRAGRAQLALVTDAADRVVGIAALEDLLEELIGDFEDETDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0I2</accession>
    <name>A0A7W7T0I2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_001405</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4964046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="34036" checksum="19F42CAAD272FDC1" modified="2021-06-02" version="1">MQRWRGLDHLPGGWGRCVLTIGVFDGIHRGHQALIRRAVDLAGQKGVPSVLMTFDPHPSEVVRPGSHPAQLSSLRQRAELVERLGVDVFCVIPFTVELSRMPADEFVHEILVDRLHVAAVVVGENFTFGSKAAGTVELLRTLGRRFGFVTEGADLVTDDGVTYSSTYIRACIDAGDVAAAAQALGRPHRLEGIVVRGDGRGRELGFPTANLSTARFAAVPADGVYACWFVHSDGRRLRAAVSVGTNPTFSGRERRVEAYVLDVEEDFYGQRVALEFVRRLRAMERFDTVDALLVRMRVDVDETRELLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0I8</accession>
    <name>A0A7W7T0I8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="91"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="153"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="41490" checksum="C53F851AD225809E" modified="2021-06-02" version="1">MRGGWSIRTRLSVLIGVLFLTGGTVLLLVTYLLVRTNLPSPVEFSVRGDTFRITEDHRYRDEVLRTLIAQSWVALLVAAVLAVAIGLVVTDRMLRPIRWITATARSLGADDLDRRRLARTGRRDELTELADTIDGMLDRLADAFEGRRRFAADVSHELRTPLATQRTLIEVALGRPDVSADTGELGRRLLTLNVRTTRLIEGLLVLALSDRGPATREPVRLDHLVRRVVDAAGGDIALEADPCPVLGDAVLLEHLVLNLVQNAVRHNEPGGRVRVRVGPDLWVENTGPVVPEELVASLTEPFRRMDRAGSDRGVGLGLTIVASVVAAHRGTLSVRARPGGGLSVRVALPHAPTEDASESCSQAWVSPSVTVPPVTTRTRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q2</accession>
    <name>A0A7W7T0Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P) transhydrogenase</fullName>
            <ecNumber evidence="5">1.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003957">
        <property type="term" value="F:NAD(P)+ transhydrogenase (B-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="347"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="470" mass="50343" checksum="8982645F7A5FDC99" modified="2021-06-02" version="1">MSEYDYDLLVIGSGPGGQKAAIAGAKLGKRVAVVDKHDMVGGVCANTGTIPSKTLREAVMYLTGMSQRDVYGASYQVKDDITISDLLSRTRHVVGREVQVVRAQLHRNQVDLMAGTARFVDPHTVAVQGTHRGEHHTITAEKVVIAVGTTPARPDQVDFDEVRVLDSDEVLALEEIPPSLVVVGAGVIGIEYASMFAALGSRVTVVEQRERMLEFCDPEIVESLKFHLRDLAVTFRFGEKVVDVAVSESGTVTTLASGKRIPAAAVMYSAGRQGATAALDLHNAGLTADHRGRLSVDDHYRTPVEHIYAVGDVIGFPALAATSMDQGRLAAYHAFGEKANELSALQPIGIYTIPEISYCGATEAELTSSAVPYEVGLARYRELARGQIVGDAYGMLKLLVSTVDRKLLGVHVFGTGATDLVHIGQAVMACGGTVDYLVDTVFNYPTLSEAYKVAALDATNKIRALDRFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S0</accession>
    <name>A0A7W7T0S0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate carboxylase</fullName>
            <ecNumber evidence="7">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_001256</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 7 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="14">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="121"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="525"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="1051"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="10">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="868"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4963897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1125" mass="121147" checksum="FAA8ADCA798850EA" modified="2021-06-02" version="1">MFRKVLVANRGEIAIRAFRAAYELGYGTVAVFPHEDRNSLHRLKADESYEIGEPGHPVRAYLSVEEIIKAARKAGADAVYPGYGFLSENPGLARACAEAGITFVGPPSDVLELTGNKARAIAAAREAGLPVLKSSEPSSDIDALVEAARDIAFPVFVKAVAGGGGRGMRRVADPAALRESLEAASREAESAFGDPTVFLEQAVVEPRHIEVQILADGVGNVIHLFERDCSVQRRHQKVIEIAPAPNLDPELRDRICADAVRFARHIGYRNAGTVEFLLDPNGNYVFIEMNPRIQVEHTVTEEVTDVDLVQSQMRIAGGETLDDLGLSQDTVQLRGAALQCRITTEDPANGFRPDTGMISAYRSPGGSGIRLDGGTTGAGTVVSAHFDSMLVKLSCRGRTFGAAVARARRAVAEFRIRGVSTNIPFLQAVLDEPDFFEGRVTTSFIEQRPHLLTARHSADRGTRLLTYLADVTVNKPNGPRPAAVDPRDKLPTVDLGTEPAPGSKQRLTELGPEGFARWLRESKALGVTDTTFRDAHQSLLATRVRTKDLLAVAPHVARLTPGLLSLEAWGGATYDVALRFLAEDPWERLAALREAVPNITLQMLLRGRNTVGYTPYPEAVTAAFVEEATKTGIDIFRIFDALNDVEQMRPAIEAVRATGTAVAEVALCYTADLSNPDERLYTLDYYLKLAEQIVNAGAHVIAVKDMAGLLRPPAASRLITALRKEFDLPVHLHTHDTAGGQLATYLAAIQAGVDAVDAAAASMAGTTSQPPLSAIVAATDYTEHQTGIDLQAVCDLEPYWEAVRKVYAPFESGIPGPTGRVYHHEIPGGQLSNLRTQAVALGLGQKFEEIESMYAAADRMLGRLVKVTPSSKVVGDLALHLVGAGVSPKEFEAEPGRFDIPASVIGFLHGELGDPPGGWPEPFRGKALQGRAAPKGVTELSEDDAKGLETDRRATLNRLLFPAPTREYLAHRDAYGDTSVLRSKDFFYGLKPGEEYSVDLEPGVRLLIGLEAIGEADERGVRTVMATLNGQLRPIQVRDRSIAAEVPAAEKADRANPDHVAAPFAGVVTPSVEEGDEIEAGQTVATIEAMKMEASITAPRAGRVKRLAVRGVQQVEGGDLLIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T108</accession>
    <name>A0A7W7T108_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-lysine N6-monooxygenase MbtG</fullName>
            <ecNumber evidence="5">1.14.13.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysine 6-N-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lysine N6-hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Lysine-N-oxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycobactin synthase protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_001929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:23228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57820"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.59" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00556"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047091">
        <property type="term" value="F:L-lysine 6-monooxygenase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="PTHR42802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="K_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="46742" checksum="18EC155C6C303637" modified="2021-06-02" version="1">MTHDVVAIGCGPFGLGLAALASTVDGLDAVVLDRRAEFRWHSGMMFDDALLQVSFLADLVTLVDPTHPLSFLAYLRDRDRMYRFYVRERFHPTRREYEDYLRWAVERLPSVRFGHEVARVDWTGDRFVVSGEGFSLDARDLVLGVGTRPLVPTALAKAQVVHSSEFLHSDVSGDRVTVVGSGQSGAEIVLDLVRRNLAGGPAVSWLTRTPVFAPLDYTKLVLEMTTPSYVRHFHSLPQDRRDELRAEHWRHYRAISERTLEELHDLLYRREFERGLAPVELRPGVAVVASERVAGETVLTCAHRDTGRLFRHRTDVVVAATGYEQAATPFLDPLEPLIRRDHRGRHVVALDHSIALDPTVTGRIFVAGADLHSHGVAAPDLGIGAVRNATILNAVAGREVYPLPRDTAYTAFTAPGEPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D2</accession>
    <name>A0A7W7T1D2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="5786" checksum="E91771069F54895A" modified="2021-06-02" version="1">MPEPAASGPGDLARCVEANGGRVLMVVASGDVVVRIAAPPGDEGRHTEAAVWKCTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H8</accession>
    <name>A0A7W7T1H8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006469">
        <property type="entry name" value="NifC_ABC_porter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01581">
        <property type="entry name" value="Mo_ABC_porter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="52"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="27482" checksum="FE40BFBECC5925FA" modified="2021-06-02" version="1">MRKVRGGRPVVLVLPAVLGLVFLLVPLVGLLARTPWRDLPERLTTPGVVAALRLSLLCASLATVVCVLLGVPLAWLLARGDVPGRGLLRALVTVPLVLPPVVGGVALLFVLGRRGLVGQYLDAWFGISLPFTTAGVVVAEAFVALPFLVLSVEGALRGTDRRFEEAAATLGASRLTTFRRVTLPAVLPGVVAGTVLCWARALGEFGATITFAGSFPGRTTTMPLAVYLALETEPEAALVLSVVLLAVSVAVLAGLRERWITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q5</accession>
    <name>A0A7W7T1Q5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23374" checksum="FF53C921B786350C" modified="2021-06-02" version="1">MRVLLVEDDDGVADALVAALSGGGHRPHRVRRGADALLSHHDHDLVLLDLGLPDADGLDVLRKIRRVSPVPVVVLTARGDERSVVRGLRLGADDYLVKPVRLGELLARMDAVLRRSRPPDEAEAVVRVGDVEIDLAGRRVTAGGAEVGVTTKEFDILAALARRAGTAVSRQQVMDEVWGDAYLAVSRSLDVHLAGLRAKLARPGLVTTIRGFGYRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X1</accession>
    <name>A0A7W7T1X1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
            <ecNumber evidence="2">1.5.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.38" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023932">
        <property type="entry name" value="Uncharacterised_CE1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04037">
        <property type="entry name" value="LLM_duo_CE1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="19556" checksum="DB3C195FFE120E76" modified="2021-06-02" version="1">MTPRLAIVSAGLSDPSSSHLLASRLGDAVAAVLPVATTTVHLRDHARDIADNLVTGFPSARLAAAVADVTGADGLVVVTPTFNASYSGLFKSFVDVLEPESLAGRPVLIGATGGTERHSLVLDHALRPLFAYLRAVVVPTGVYAASSDWGSAHGLSGRIDRAAGELAALLGGPALARPGERFVPFEELLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T228</accession>
    <name>A0A7W7T228_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046197">
        <property type="entry name" value="DUF6229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19740">
        <property type="entry name" value="DUF6229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6542" checksum="446A61E386ED05A8" modified="2021-06-02" version="1">MTTALLPDAEELVARWRAGLDGIDNPAGPLFANGEFAEGDIVACNPPGSRCSACTASRPVYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T253</accession>
    <name>A0A7W7T253_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6135" checksum="ED10B5B0EB734546" modified="2021-06-02" version="1">MGGTRPRRTATTPARAASGTPCSATPSGYRRFRALPVLVAAVVLVVTGRVEVAEPGALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E3</accession>
    <name>A0A7W7T2E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20862" checksum="F22E8DA9C7E53547" modified="2021-06-02" version="1">MRDVIYLERIEQAEALLKPQRIEVLRQLAQPRSCTEVATVLDQTPQRVYYHVKRLVEAGLATQVDARRVRGVTEGVYQAAARSYWLSPGLVGRLGPDRVRDELSLGHLLDLAERVQSDIAALDRTRPELPSLGVSGEIRVRPEARAEFFAELRSTLQDLFSRYGAPEGDAFRLVVACYPKDESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M1</accession>
    <name>A0A7W7T2M1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="42943" checksum="F6475FCA2ACC631D" modified="2021-06-02" version="1">MRNALSLPLVPWEGGPKYYGQFAKSSAWNDPNFFPIAVWGATVGSQKDIDLDKAVGINTYLELYDTPRLDLIRDAGMFAIHDQTTNPNLGSETVGWLLADEPEQFGQGDALNLLKSTSAKLPNDGRMRYTNFTANMIWPNYAPEDGMAAQWLEVNGAVSLDTYWYGRFMGCDRLSHPDLPARNQSLLTEDECYRPSNYGYGVTKQREIAAESGKTESVFGFVENGRPYAENPAIKPDHLQAAVMSMIIHGARGINYFNHTYGDWCPSSNNFRYTALFGGDCYAAMTKAATKVNGQIKALAPVLNSQSYAWTFNPSLDTMLKVHNGYAYVFAMGSGIPGGTATGSFALNLPPEAAGSTSVEVVDEGRTIPVAGGKFTDTFASSTAYHIYKIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T307</accession>
    <name>A0A7W7T307_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NBD/HSP70 family sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="38786" checksum="C085048FF0E69986" modified="2021-06-02" version="1">MPASPSVARAINDRAALLLLCDGPLTAGRLAELTGLSRPSTADLLKRLQGAGLVTVVGAAEERRRGPNALLYGLISDRVHVAALDIRRQSASVVVGDLLGDVLAEATVPLDGGRHAVERTTELLAETLGAAGVDTPHTICMGVPGLVDPATGTLRVVPGMPDWHVPLIQALRASLPRLVVDNETTFAALAEHRAGAARDRDSFAMLWLGNGPGGALVLDGKPRRGASGGAGELCYLPVPGMPVPTATGPGGLHGLVSSDSVVALAADHGVTAPVVPGEPAGAAVTRAAVEAGADRFLDALADRVAVGAMAITAVVDPGCVVLGGELGHAGGAVLADRVAQRLLAATPMPTQVRAGAFGGAGILRGALLTACDAARDDLFGPADPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T391</accession>
    <name>A0A7W7T391_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24970" checksum="2A5E05F79230CE83" modified="2021-06-02" version="1">MPRPADPVEPPWWTPRKQPTARRNLTREAIVTTALAVLREEGVDGLSMRRIAADLGTGPASLYAHVANKDELLELLVDEVMGGIEAPAVDPARWREQLTGLWVAAYQGLLANGDIARAIMARVPLGPNALRLSEAATALMVAGGVEPRTIAWSLDIISLYVVGSAVEDAVSTALARSGRDAGEYYQGIADYLAALPAERFPHLVALSAEHAQGDRDERFRFGLDLLVRGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T394</accession>
    <name>A0A7W7T394_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="29061" checksum="825643F1F23130BD" modified="2021-06-02" version="1">MNEPILPDPYWAGMITGRLVHLHLGLVDHQLVRDHRARERALIDSAGTSVAVVARLDGTRPADRVLARLLGCAVGGPLADGIRLLDRFVRQDSGPLVFDEPGSGLVSDGADRAYRRAAELGLEPVCQLGIGLVGLTSLPAVFEPAVDREAVLLPAATWSLPTAELTASVLEGAARSLALTWAYAEVLAYGLDGPPPGTTAAATDFARGVLAEYHRRADGRHGPDPGEPTQVPELPLLSELVRCWWPAPGRAHNIFGSPFDYMTHLEVSGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3D6</accession>
    <name>A0A7W7T3D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="13420" checksum="F1A95670BAF66D24" modified="2021-06-02" version="1">MLFYAFPVLSGRIAVDTGWSAVTLTAWFSAARSVSGLVGIPVGRWPDRRGPRVVMAVGSAVAVATAHDPVWFAAGWLVVGVAMGMVLYPSAFAGTAPARLLGGHASAFVLLGVTTLGTAFLSLATTRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T419</accession>
    <name>A0A7W7T419_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14817" checksum="089D8052FD80E112" modified="2021-06-02" version="1">MEALPEGIAVPRPGGVGRPRRRPDSLTADKAYGSRANRAALRRRKIKAVIPQRRDQVANRLRKGSAGGRPPSFDADAYKRRNQIERGFNRRKQFRALATRYDKLALHWQATNDIVETIDWIRATPDKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A9</accession>
    <name>A0A7W7T4A9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="7454" checksum="A80596614FE2E82E" modified="2021-06-02" version="1">MAASVTRAHLAVDKAECQGAGLCHALAPELFRLDPQGFGEAVVSDLDDPDDIEAADSVVGGCPAAAVLLTYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P0</accession>
    <name>A0A7W7T4P0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LuxR family maltose regulon positive regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="795"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="862" mass="92633" checksum="F830761CA2946947" modified="2021-06-02" version="1">MSERHDPSETGRPVPPPKLRVPGMEAPLVERDRLHACLDGRTTTTAPPVTLVLGPAGAGKTTALALWARRRSDSTRVAWVTLDAQDDSPVGLWSAIREALPAGLAPRDRLPDLPPATTPEFAAAVIAALDHVTTPVHLVVDDVHLLTDRIALHGLELLVRHTPKSLRLVLSGRSAPPVRLSRLRLEGRLRLVDARDLAFTRAEAEELFAGHRLRVTADALDAIMARTEGWTAGLRLATLVLAESAPAEFSGALPAVADYITEEILGDYDEQVRDFLVATSVCAEVCGDLGAVVAEQPDAGRFLERLSRDNALVSAVDGADGWYRYHPLLRDHLSAELDRGAPHDRKRSHLAAARWHRDAGRAIDALDHAVRAEDATLAAELVAEHGLREVLRGNGDRLHDLVTSTPRMACGAAAATAALAALDEGDLAGADWSLDGVEVGRSPRHRALSAVVRLRRARFTGDLTDALRTLPTPTTGDVALDLAIRLERGIATLWLGDHRAAEQELRAALDLASREGLDHAALVASVHLTAAAAARGDTVGVTDHGDRSMAIAAARGWENRPACVLVYAVLAAEAHRRLDDALARRMVTLAAEALPRHADRTVELAVAAVEAITTFEDAEDPHAVVSALWKQWQGFSEPYVAPHLVASVVPTTQRMALRVGEPGWAGDMVTHVEAVLGTCGELALLQAVVHSQRGRAAQARKVLEPVLRGELPVVVPTTLVDAWLLEAGLVDREGNSQQAHEALRKALATAEPADALRSFHNAGKPVRDLLAKGAGRFGRLDRFATAVLTTVPTPRTGDPDSLTGRERALLVELPSMRTAEEIADSMYVSINTVKTHLRGIYRKLGVSQRRDAVVVARRLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R5</accession>
    <name>A0A7W7T4R5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diadenosine tetraphosphate (Ap4A) HIT family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="16073" checksum="A001C3B72A65B278" modified="2021-06-02" version="1">MRYPKAVTSRPTPHSGCLFCRPDDPESNEVLVEGDLVYVRRDNYPAAKGHVEVVPLRHVESYFDLTPEEAAETHELVKKARRMLDEEFHPDGYTIGINEGRAAGRTVDHVHIHLIPRYTGDVADPRGGVRHVLPGTDPDRWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T500</accession>
    <name>A0A7W7T500_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="480" mass="48932" checksum="CF55169E2844D2F8" modified="2021-06-02" version="1">MTSYEPDPRRWRAFSVSLVAGFMSLLDVSIVSVALPSLQHGLGTSAAGAQWVVSGYALAFGLALVPAGRLGDALGRRTVFLVAMSGFVLFSALAGLAPTAGVLIAARLAQGVAAGALAPQNSALIQQLFRGAERGRAFGWFGATVGISTAVGPVVGGVILAVAGEDDGWRWVFYVNVPIGLAALVLAARLLPRAADVRRRDHLDLVGAALLGSGVLAVMLPLVLAESGGLSSLWWLFLLGAVVLVGFVRWERRERARGRSPLLDIGLFTTTPGYGTGALLGLVYFIGFSGIWLVFAVYFQSALEYSPLESGLAVTPFAVGSAVSALIGGRLVETWGRRLTVTGLGMVVAGLALTAFLLWLTDGYGAGVAVALFVAGVGGGWVISPNTTLTLRHVPVAMAGAAGGALQTGQRIGSAVGTAALAGLYHAVLTGAQARVAVGVAVGTAAVAVTAALVVGIVELRARPTCPRAREAGVSVSGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T569</accession>
    <name>A0A7W7T569_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="421" mass="45245" checksum="33992B5CFEFAC1F1" modified="2021-06-02" version="1">MAARPLTPLAAAREAAGYTQESLAVTLKVERTTVGRWERGVQSPQPWQRPGLASALQIALDELDDLLRRTARHSTRPTSAAVLASAPIGLELVPPAPPTGDRHEREPVAEIDVIHAAIPRLRRALDRLDLPDDGPTRTPADLHGDIARASDDRLQSRYGNLARRLPDLITELARAGQLGDTADRRHAAALLTLVLRAADGVAFKLGYLDLSARLIDLMRSAAQLAEDPLLLAAVAYVRTETFFANGDLDTAARALELAADHVPGLETASASAAFGALHMRAAVVAGRAGKPDRASDHLREARRAATAVPEGVYQGTAFGPASLRIHELAVSVELRDPPGIERAAVWYPPDTLPAERRSPLLHRPRPRPADARPSRGRLPVPASRPPGRAHPQVRRSLSTLLRTHGAPSTGLLDLAAWARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5D3</accession>
    <name>A0A7W7T5D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19277" checksum="90515EE8A8EFE6E7" modified="2021-06-02" version="1">MSTKTDFYLGRGHDAEWLGSLQWECEPENLLRVPPGRLALTATDEPTYRAAVADLFIVWETEELGAAYPRRTGWPWPWATSHVSSWIVAFDPAAPGVFLTVGGGVRWEPLDPRNPREPAEDIGPPDIHAWLRAPADPPSVPLPLMRDPATGLPTAAGQCLTNPHDTRHDTEGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K3</accession>
    <name>A0A7W7T5K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dipeptidyl aminopeptidase/acylaminoacyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="382"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="591" mass="63801" checksum="8B2F0354A02B6C2D" modified="2021-06-02" version="1">MTTDFEWLSGAEPGPGGEIAYVSDATGRPQVRLLRAARHLPVDGSVRRCAWRPDGTRLLVLVDPDGGEDHRLAEIDPVTGAVEWLVAEPGVRCEVGVPYGTASAPYSPDSRLLAYASNARDREVFDVHVRDLATGATRTVLTGDDRWLPVSFSPDATKLLVLRLHQNTEHDLVLCDLRANTVTPLTDRTGPDKYEPIGWLPDSSGIHVCTTHGRDFMGLATLSLDGTLTWTATPPSDVEGGAVRGDLVVWGVDVGGWTRLHWTTTGSGVTHEVEGLPPGVAVHEFGYSGFVPRFTHDGRLLVQLGRPDAATELYLADLAAGTAEKLTDFGARLPNNLVVPREIRATSADGLRVRAHLYTPHEPNGALVVTVHGGPEYQAYPTFDPLVQELLARGIGVLAPDIRGSSGHGLRHQRLIYGDWGGGDLDDLAAITGALADVDWVDTTRLGVHGASYGGFAALSCVSRLPHLWRAGVSECGSSDLVTDMLSAPPTWRKRLKAWIGDVDDPVARAELTARGPLANAYRVTAPVLLLHGENDTRVDPEESERMYRRLKELGKPVELVRHPGVGHEVDRESLAATVALIADWFTTHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M8</accession>
    <name>A0A7W7T5M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ENTS family enterobactin (Siderophore) exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="43117" checksum="F2699F70AE30402E" modified="2021-06-02" version="1">MRLGDLVVDVTPLRESREFRFLFAARLVSLLGFGLTTVAIPVQIYGLTGSSLQVSLVSVVIMVPMLVGTLAGGILADRMDRRKLIVPARGSAVAVFALLAVNTTFEHPQLWLIYLCAAVNSVLNGLSATALMAATPAIVGRARLAAAGALMAITAELGAIIGPSLGGVLTAGLGLAWNYGLTAVATLLTTLLVSRIRSLPPTGQPEESPLRSVVEGLRFVGRSRVIAGLLLIDFCVALFTVPFALFPELAERVFAGGPGIVGVLYAAPAVGAMIAAAASGWTDRVKHTGRYLVAATIACGVAVGGFGLSGGVLWSALVWLALLGAADTISEILRRALLQHNTPDHLQGRISALWLAQTNVAPALGSVEAGVLARLLGPVTAIAVGGALCVVTSAGVGAAMPALRESSLQDPSADELAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P5</accession>
    <name>A0A7W7T5P5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13855" checksum="3DDF4F83F4A2D4DB" modified="2021-06-02" version="1">MARFQCYRTVQTGVRWRLLGGNNRVLGVGVRVHLDQAAALAEIEVVRVDGAMADFTIEHADNGAWWWRLGGLARSAQGFARRVDAELAAARFRDRVADAALDPVLAVFQPGRRGRSSRGRSQRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T691</accession>
    <name>A0A7W7T691_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="22423" checksum="BB836037D1CF3F4B" modified="2021-06-02" version="1">MLIWINGPFGGGKTATAHELHRRVEGSVLADPEYFGFALHRLLPPALRGDFQDLPTWRTGVYDMLDLALTQHEGPIIVPMTVVNADYFAEIVGRLREQGHRVEHFALLAEPATVLARLSGRGLWPGLKREGWAVSKLDHCLKRLHEPEFAEHVDTDDRTVAQVADAIARSAGLPIVPDNDSPLRARLRRYATSVRHLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6F4</accession>
    <name>A0A7W7T6F4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="16118" checksum="B197963AC2A2C242" modified="2021-06-02" version="1">MIPTTADFYDETGRQARWLGAIHGNADPETLRGLDSGRHMLDATDPTTFAEAALDLLEAFSQQNLGHSHHPRDGWPWSWPDSRSTDWIYTFDRGRTWVITGRIWSYTMPRVDHPPPRLAATGHVQPGPTQDSTERHGNTCPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I0</accession>
    <name>A0A7W7T6I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="388" mass="41670" checksum="630FD501BB90AA6C" modified="2021-06-02" version="1">MRANTRAGRNKVEVRDVPDPRILNGRDAIVRITSTAICGSDLHLVDGHVPTMQDGDVLGHEFMGEVVEVGSGVGPDKLRVGDRVVVPFPIACAACAAELYSCCENSNPNAGIAEGMFGHPVAGIFGYSHLTGGFAGGQAQYARVPFADVGPLKIESDLADEQVLFLSDILPTGYMGAEMCDIQPTDVVAVWGAGPVGQFAMDSARLLGAAQVIAIDKEPCRLAMAERAGHTPVDFDEVDVRSRLLELTGGRGPDKCVDAVGMEAAHGSAHISAYDRVKQAVRSETERPHALRQAILSCRGGGVVSVIGVYGGLMDKFPAGAWMNRSLTLRTGQCHVQRYMKPLLERIERGEIDPTRIITHTLPLDEAERGFEIFKNKQDDCEKVVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M6</accession>
    <name>A0A7W7T6M6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA ligase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="37644" checksum="1CE3CF3889980477" modified="2021-06-02" version="1">MAAKAEELQVGDRVVRVSNPDKVYFPERGITKIEVVRYYLAVAEPLLRVLRDRPTTLKRYVDGVEGEWFYQKRLPKGVPDWVGTARVRFPSGRPADEVCPTEPAVLAWAANLGTFDFHPWPVRAADTDRPDELRVDLDPQPGTDFRDAVRVAEVLREVLDELGMVGYPKTSGGRGVHVAVRIRPEWDFVDVRHAVIALAREVERRMPDRATTSWWKEERGERVFLDFNQAARDRTIASAWSVRGTPRATVSTPVTWATLSTVDPDDFDVRTVPAYLADDGDPHATLDDTAYGLETLLEWYAADPRGELPYPPDYPKMPGEPPRVQPSKARKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Q2</accession>
    <name>A0A7W7T6Q2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="259"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="797" mass="88883" checksum="74B8E2EEBED29CDF" modified="2021-06-02" version="1">MVKQLAASWFRERKADSRRGRDLTSLIRARFPLPRDERDVLSALWQVEDQVTAKLAPACARLAHGLPENEVTAALDAVTDTLADADLSDEALVGVDLDPVALYQEIRRGQPLAVRRAGPEPRAAELYDAALRRACVALAHLARELPEFQGVSAVASLRRLTSISSKLDVLLDRLPAPAAGERFRDDYLAFVASTLDRLDLLGLSMRNRPRLALSMAYLSLSVNSEERRRARTDLIKDWFATARRDHGTTRVERALSASSRVLVLGDAGSGKTTLLHWIAVTAARSGFSGELVRWNGRVPFLVTLARFPNATLPAPEDFVFDLLAAEQPEGWVRERLRTGDALVLADGVDEVPPTRRRVVREWLRELCSAYPEATYVVTSRPAAADRLWLADEDFSSVTLDRMSSPDIQVFVDRWHAAAADARSLPCDISELPAAKERLRRQLSARPHLRMLATNPLLCAMLCALNLERTAELPRNRIDLYRKALDMLLHLRDSERGIDSPLDTAEKTALLRDLAWRLTTGNRAEMATSTMLEYLGHKLPGMPNVDLDADEVAGLLLARSGVLREPTPGRVDFVHRTFQEFLAAEEAMEDHQVHTLVANAHRDSWWETIVMACGHAKRPQLRELLSELLERAEREPRYARRLRLLTAACLETVTEIDPVLLAGIETMIRTKLVPPRSLRETRSLSGIGHRVLRYLPPNLTGLSENAAQATVRTAWQTGDAEAIVRLAGYARDPRVGVQTELITAWDYFDPETYAIEVLADAPLLEGWVSVWSARLIPHLRHLRNLAGVMLAADESGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E0</accession>
    <name>A0A7W7T7E0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031546755" evidence="7">
        <location>
            <begin position="29"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="165"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="496" mass="50769" checksum="65CB7BD088A075C4" modified="2021-06-02" version="1">MPLLRRARAAAVGVALLATGFAPGSASASIAVPTYAAADPDEVGASHCIQPGPTLRYLVVFDEGTSSPLADALVTGACGTIATYHPQISVAVVTSADPGFGTKMGPERAYSAQADGRSRRTPAKKREDEPVGSRTADGTLDRTAEQWDMELIHAAEAHAVSTGSRDVVVGVLDSGVDPTHPDLVDALDPELSAGCTTGVADPAEAAWSPTTSVHGTHVAGTIAAADDGRGTTGVAPGVRIASVKVVDDDGFIYPEYAVCGFMWAATHGMTVTNNSYYIDPWVFTCQNQDGQKLVYEAVRRAVDYAAARGVLTVAAAGNAAVDLTKPGRDAQSPTNAAPEDVKPRPVDNTCLVLPAQLRNVVAVSSVGANRVKAGYSSYGLGAVDVTAPGGDRRQVPADGGQGCVLSTVPNGYDYSCGTSMAVPHASGVAALIASQHPSAGAGELGRMLNAGAQTVPCPADYDLNGTGVQDAYCTGYSEYNGFYGHGMVDAEAAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E5</accession>
    <name>A0A7W7T7E5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="24443" checksum="C297E846E16FB619" modified="2021-06-02" version="1">MTSFAALPATRTAPTAEVSGPPVVLVHGFASNGAADWPAERWADALAAAGRETIVVHLPGHVGGPAVSSADEVTTTQVLGRIAAAVGDQEVDVVGYSLGARLAWDLVSSVRVRRLVLGGLSPMEPFGAVDLAAARAAVQGGPQPTDMLTGIITSMVAQQDATSLLLLVEGLAREPFNPAAGAPTVPTLFLAGEADPMAQGIDHLVGLVPDARLVRVPGDHLGALAGEDLRKAVFEFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N1</accession>
    <name>A0A7W7T7N1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="30860" checksum="9B99E157F78CD8DE" modified="2021-06-02" version="1">MTALVDGADYARLLTIVEQRAGRYAEDLESVLARAGLRGEESRLLDEFEQCVSGVLDHYPARRRRASHELLFRPFYETRQESVDSERRRTLLVALMAAEVEAQGPLRLTMAQNKDLAEILERLGVDCAAEGLWLHAAEAFERAAETHLLTNDHAARDRCLFLQTRARHRIEQRPARRAFLAFSAVTCGYGYRPYRLLWWVLVQLVAFWLTLWLVTDALTPYNLYLAAVNYLNPAGTEQASGAVKAVLVVESYSGALSLNVFFALLVRRWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N2</accession>
    <name>A0A7W7T7N2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="11334" checksum="4585DF8C01959C1F" modified="2021-06-02" version="1">MVMKHYPPEFRAEAVALYRSRPGATIKSVAQDLGVNHETLRNRIQLDDAQRTGAPTTASASVPASPENENAALRRRVRELEEERDILRKAARYFAGETRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y0</accession>
    <name>A0A7W7T7Y0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35144" checksum="5DC96208391B214E" modified="2021-06-02" version="1">MDLPDRPRALPGLPLLKRHRDVVQIGVDGRHAVIVEQLPPPLVEALLGLRGRHTLAELRARLPHHADDLVGVLRGLVEAGLVDETVPQDGRLTAETTAWALRTRRSARHVPEARAKRCVAVRGDGRLAVAVAAQLAAAGVGFVRVRAEGRVGAEDTGCGYLDADVGRPRAEAAADAVRRARETVRRGSGAPDLVILTDALAYGPEVAWPLMKARTPHLVVRAREGLGVVGPLVVPGRSSCLRCADLHKGDVDDGWPMIAAQLADLPQHADLATTTATAGCAVAQALQALDHGDAAIARPPTWDATLEVDAFAGSVLHRIAPVHPRCDCRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T864</accession>
    <name>A0A7W7T864_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="15961" checksum="4591FA4B5B4CD972" modified="2021-06-02" version="1">MELERRLAELEQRVAALEGGTTPAEGGGTLGYRGRVTLGGEPVERHVDVTPAHALHLDDRPRLEVLAALAHPVRVDIVRCLLGAGSRPSTALQEAAGLGSTGQLYHHLKALTAAGVVEQDRRGSYRLRPEATVPVLVLLTAAADVAGQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C2</accession>
    <name>A0A7W7T8C2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031043267" evidence="2">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12100" checksum="E6D216071D1BF1D7" modified="2021-06-02" version="1">MVRALTTFVVFVLLAVLTPATAHLAPVVVRSAHSAGMPAEEEPPREARQAPEPRVTLCPRRMSPVRRRPLHRAPSAPAHEISTRPVRPCARADHLHERTAPDVLQVFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8F3</accession>
    <name>A0A7W7T8F3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="39" mass="3887" checksum="A38F5B3C426CF2B4" modified="2021-06-02" version="1">MGEAVGEAVVEGVATEEATGSDPHDTASNATPATMTLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J8</accession>
    <name>A0A7W7T8J8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23343" checksum="853A9C12A7D730FD" modified="2021-06-02" version="1">MRVMIAEDSVLLREGLIRLLALAGLETVAAVGDAEALLKAVDAERPDLVITDVRMPPDFRDEGLRAALVLRRSWPDLALLVLSQYVEERYASELLSTYSTGVGYLLKDRVADVGEFLDAVRRVLDGGTVLDPDVVAQLLVKHRHQPLDRLTPRESEVLSLMAAGRSNSGIAKALSVSESAVAKHVNSIFGKLDIPIKDSDHRRVIAVQRFLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K8</accession>
    <name>A0A7W7T8K8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose/arabinose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031081925" evidence="2">
        <location>
            <begin position="27"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="3">
        <location>
            <begin position="41"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="38466" checksum="6EFA749E51D54138" modified="2021-06-02" version="1">MRRFAGFAIPLLLTGCATAMGGTAPAATAEPLKVTTVVSGLTHPWDVGFLPDGRFLVPQRPGRIALVDKGVATTLTADLSDVVARGEGGLMSLLVHPDFATSRQFTTCYNTASDIRLVTWELDGTTARKVKNPLLGGFPVNASGRHSGCKLAVDKEGALLVGTGDTANARAAQNRQSLGGKVLRLNLKTGAAFTGTDRVYSYGHRNVQGIAVRSDGLVLTAEHGPSTDDEINLHKPGNFGWDPSKGGTQDRYDESVPMTDTRRFPDAVPAVWSSGRPTEAISAAAFLSGPQWKTLDGWLAVTALRGTKLLLFSVAKDGKVANRTVPPELSTKFGRLRAAVQGPDGALYLSTSNGTDDKILKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P3</accession>
    <name>A0A7W7T8P3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="335" mass="37435" checksum="4FEF5E22B8BBAB1A" modified="2021-06-02" version="1">MTSTPVYSEASSRPEPRHLALAHLSVEVGHFYMEDLAGGDDRVRTQFRKVAPWLEATRSALAADLDGVRPRLSTCFLVDDYFRSDTAPEEVVDRVLSIAEEYGVRIDYLAREAGCSEADRVPLAELTAAMLLPEPPVGSNGSRPPVQDSGWLCNGERSPADHTGRQAMMPREEWRPAVEFGKRNHSIFLDVELWRDRTEVVDGTPGQRRLWSCPFLAAVWQLMRLGALRHEGEPVAQPRRWSGPWPKRWADLPAVIQLTEHPAPFAAYRTTSILPQSYLGIEHATNVILNHLDVDEAVIAQTVDRAQREGVFVPAQLGARLSHVFIDAPVAGPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T1</accession>
    <name>A0A7W7T8T1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="453" mass="49800" checksum="580A3A765ECBA18A" modified="2021-06-02" version="1">MLGDEVWQLLDDALGVYRDDPRATAWLRGFAARLDEPLRIAVAGPHRVGKTTLVGALIGEEFAGGDAFLWYRDGPRAHAHVGRHEVPVVRRDGRIAVEATGAERIDVEWPSRSLRDLVLIDSPARASVERVYRDADAVLYLTRHMHSADLEQLRSAHDHPFARATPVDTVVVLARADEIGAGRIDALSSARQVARRYRREASVIPLCQNVVAVSGLLAVASRTLRDDEFTALSTLARHSRVDLEDHLLSVDRFVSTDLPLDRSVRHALVERFGIFGVRLTTTLVRQGCDTPVKLSAQLAQRSGLGELRESIGLYFAERRDVLKARAALLGLDVVLRATPRPAAARLTAAMERLVASAHDFRELRLLAALHAGRVRFSDELDDEAVRLIGGTGTSMLARLAIEYEPTDGELRHAVLDAVARWREHAANPVLDNAQRRAAAVVVRSCEGMYAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T5</accession>
    <name>A0A7W7T8T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="335" mass="35991" checksum="C1481FDE97257D9A" modified="2021-06-02" version="1">MPELELRHLRAVCAIAEEGSLTKAATRLGLTQPAMSAQLRTVERIVGGQLFDRTPGGSVPTDLGKQVVGTARLVLDEVGQLVSLAKSRSTNDGTPGPLVVGGVPTLFFGHFVEELRRTIPCSEVRTEILPGGSALLELLVSGQIQLGIVDRFEGMERRELRGLEVRRLVSEPQFVALPDWDPLAAEDEVDLSALADRDWVSPPDESVGNRLQIFSVCADAGFTPRFAHHVNEASTARSLVANGAISFALPQSRSGDGIVIKPLRGAPLMVDLLLATRREGPAAGRAHDVFACAAKAYKAVLPRNPAYEAWWDKHPEAHPELDAALLMAEASAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V4</accession>
    <name>A0A7W7T8V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030776808" evidence="1">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="22498" checksum="E97C63057EA3405F" modified="2021-06-02" version="1">MNHNRAHRRAAVVAAALVTGLLATATPALADNPPGIASVGAANFVEDGDTSYIADLAQCAVDGTTYRSTIGKSDTGVKFGPGYSTCTTTVVDPEEETTSTRSEANGTLFELSALVSESGPRLKVGSWRSTCSATQGGTTAGWSISGLSGFTGLPAQIPANYVLPIKRGTTVLATATFSEITLPNPNDGSLDMNLLHIRFTPASGITGDVVLGHVACSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T954</accession>
    <name>A0A7W7T954_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="42611" checksum="41C57AB028D206C7" modified="2021-06-02" version="1">MSEDLSGRRLGHYRIDGVLGRGGMSVTYRATDVRLGRKVALKVIGEHLTADAEFRERFVDEARNTSAIDHANIVPLYDFDEVDGLLYIAMRLVDGQDLASHIKDGPLPPARTLTLLAQVAEALDMLHGKGLVHLDVKPANVLVTTKEAVREHVYLADFGLTRRGATGHRTRTGDFLGSPTYAAPEHLRGEPLDGRTDQYALACMLFACLSGRPPFQGGVQEVIQGHLGAEIPALTTLVSVPPAIDEVLRKGTAKDPARRYGSCQELVEAARVALAGAPQQAPARVEPTPQYRPTQPYTQQQARPQSFPEPVRLRPPAPVGVSAFTSTKKQRPTWVAPVLVGVVAIALVVILVVILTPKSEPTRPAGGTSSNQSIQVGEPTSGSRGLPTSVPVRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T963</accession>
    <name>A0A7W7T963_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23112" checksum="5CD2B7CE11E73A14" modified="2021-06-02" version="1">MRIAIAGAGAVGRSIAAELVSDGHQVMLIERNRAHFEPHTVELAEWVQADACELSSLEDTGLQLCDVVIAATGDDKVNLVVSLLAKTEFAVRRVVARVNDPANEWLFTESWGVDVAVSTPRILSALVEEAVTVGDVVRLMTLRQGQANLVEITLPDDTPLAGSPVNGLALPRDAALVTILRGGRVIVPGPEDSLEGGDELLFVAAADVESEIRTALGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9E6</accession>
    <name>A0A7W7T9E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="6304" checksum="31DAA4AB3D21550C" modified="2021-06-02" version="1">MSGNAEWTADGWRELRSCLADLLDRCEEINGRLARVEDHLKVARTARTPPRRPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9L8</accession>
    <name>A0A7W7T9L8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="45991" checksum="77D31F4A4E2E3202" modified="2021-06-02" version="1">MSSDVPDWARRIKALREARGWSQSEAAERMRQHTEDVLPEPDHLLRRWKAWERGQNKPSPHYAPIIAATLHSVTTALFPPETRIESGLEIVNATGMDTMEIVARLQSSSVNDATLQALRITVDQLCSEYAHSRPDELLMEGRRWLRRIVEMQEQRLSFSQRRDTLELAGWLALLVGCLEYDLGDRRAAEATRQAALNLGQEVGNPGILGWAHEMRAWFALTSGDYRGVVAAAQTGQANSGNHSVGVQLIAQEAKAWARMGRQPEMENALERGRALLDSLPYPDNISNHFVVDPLKYDFYAMDCHRHIGNDRLASTLAEEVIRNGTDFNGFERAPMRIAEARITLGVAAARSGDLDTAISYGRQALTGQRRSLPSLAMVSQDLAMALTNHFPDEPDALDYLNQLHEIHRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N4</accession>
    <name>A0A7W7T9N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32411" checksum="A359CFB208665277" modified="2021-06-02" version="1">MRAGIVILPEDRWWAAEPKWRGAEEYGFSHAWTYDHLGWRSLVDRPWFSAVPVLTAAAAVTSTIRLGTYVATPNFRHPVPFARELLALDDISDGRFTLGVGAGGSGYDTHVLGGGGPLAPAARGKRFAEFVELLDRLLTVERTDFSGEYFSAVEARSTPGCVQRPRLPFLIAANGPKAMAVAARYGSSWVTTGPDTEDDDAWWAGIAESAARFDEIAAGRVPTRHLNLDSGPVFSLTSVERFRDCVGRATALGFTDVVCHWPRDEGVYAGRESVLEQVAADVLPELAAPRTGSPTHPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U5</accession>
    <name>A0A7W7T9U5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17987" checksum="9088046860C812CE" modified="2021-06-02" version="1">MTEQEPRWLDAAEMKAWRNYAIGAAMLADRLHRELQDNHDISLADYQVLVRLSEHRGLRMRMSQLAEEVASSKSRVSHQVARMERVGLVRRRECPEDGRGVFAELTDKGMETLRTSAPTHVEGVREHMVDLLTRSEQEVLARVFDRVITHLRGRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG1</accession>
    <name>A0A7W7TAG1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="27621" checksum="376F892408488AE5" modified="2021-06-02" version="1">MTVVLSTLEFDVAWEAERHPRRNVALDVPSPGITHTERAAFVENAWHSLEERGLAHNRRVTPEIADAFALLANPKVSVDLWIWVDGRKIRGLAAAGSDEAVLGVVDGDEVWLIESRATALADDAVSVTGERPAGRGRSVSLPNDVFRAAADEAGRDADKLVLSLEYHGIPLHEAQELAGMVDGMGTRGQFGVERARPGGPPVRANRVVAWHDTPSGRYLHLVRPSSDGRDWSTITPIDNHRLAVCVRELMQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTB8</accession>
    <name>A0A7W7WTB8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase / fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="9">1.3.5.1</ecNumber>
            <ecNumber evidence="9">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="9"/>
    <dbReference type="EC" id="1.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29140" checksum="A0FD65BF36053558" modified="2021-06-02" version="1">MTATAEAPAGSRGSQPPVPDGAITVTLKIRRFNPEFDDEPRWDSFEIPALASDRVLNLLHYVKWYLDGTLTFRRSCAHGICGSDAMRINGVNRLACKVLLKDLLAANGKPTTITIEPIKGLPVNKDLLVNMEPFFEAFRAVKPYLITYGNEPTRERVQSVADRERFDDTTKCILCACCTTSCPVYWTEGSYFGPAAIVNAHRFIFDSRDEGAEERLDILNDVDGVWRCRTTFNCTDACPRGIQVTKAIQEVKRALLFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM9</accession>
    <name>A0A7W7WTM9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14265" checksum="00C0C687DA690753" modified="2021-06-02" version="1">MTTTTIARPVAQDVTLTAFRVVVSFLFGCHGLMGFGLFGGIDGQGGAVEAWSFPGWWASVIEVGGAAFVLLGVGARVAALLCSGTMAYAYFVVHQPEGLLPVQNMGEPAVMFCWAFLVVAVVGPGSYTLDRVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN1</accession>
    <name>A0A7W7WTN1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">F4559_000256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_053715226.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6962" checksum="E3BC2FE467B6EE63" modified="2021-06-02" version="1">MAKKALINKAAAKPKFKVRGYTRCQRCGRPHSVFRKFGLCRICLREMAHRGELPGVSKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTQ7</accession>
    <name>A0A7W7WTQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SRSO17 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30986" checksum="84E6ADA6F5D28B3A" modified="2021-06-02" version="1">MERRFVPSEGRAINCQLATGLFLAGEAASIPVDWRIQLTERWTTDERRRDRAYIPATVRAQPAWRYALDVVEEVADWGIDRVPVVGDLRHTPDADRLMARLSELGTDFVFEVSDMLQVVPGPHLAAVRPSGGPRSGPHLLRVRDCLRGADVKHRQVVTWTPGVDGRHRATHAVSVPVRLPGGRGGATLQLVGTSWQGGRSKLWLTNRTDLRAAEVISLGTLVERTEADLRDLRADFGLLDFEGRSYRGWHHHMTLVSAAYTFARLTAAPRRQERRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV7</accession>
    <name>A0A7W7WTV7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26300" checksum="5B47CF61E23E9D0E" modified="2021-06-02" version="1">MDSELLQARLGRRYPSITVVDRTGSTNADLAALDAPDRTVLIAREQTAGQGRRGRDWSSPGGGLYLSVLYRPGISPDRVPWLTLLAGVALVRTAASFGVEARVKWPNDLLIGGAKAAGVLAEASAPGVVVLGIGLNVGPLPESVRPGPGGLPPTSLGVDVPVLDVAVTLLTELDALESAWRGDSGDPYPSGLLAEYRSCCATLGQEVRVELTDGVLVGTAVRLDQDGTLVVRDGSGREHTVSAGDVVHLRPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTY9</accession>
    <name>A0A7W7WTY9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="32417" checksum="F505BADE75ACB559" modified="2021-06-02" version="1">MTLHQLAYFLAVARTRNFTRAAEQVRVAQPSLSKQIHALERELGAELFSRARGNVALTPAGEALLPVASRIVSDVDTARLEVAELVGLRRGRLRVGATPSLCGSLFADVLKAYHDAFPGIRVLVEEGGSRDLVRALEAGDLDLALVIASPVDADRALTVIPVLREELVVASPTPFDSARLPVAALRDRPLVMFRTGYDLRETTSAACREAGFEPRFAVEGGEMDAVLRFVEVGLGWAIVPSTVLATRSLHGVPLEPGIDRVVAVAHRADVAPTSAARAFLDVLNRYLRGVALPSGVHALGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU30</accession>
    <name>A0A7W7WU30_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="12667" checksum="94BD7E51E45087BC" modified="2021-06-02" version="1">MITTDLDTVLATLDRTDLHCRCPRPDTCRDVHAEHEDLPRGEYGLAFVHPDGRLHRAANAEAFGQQGAQYATLADVLAALDDWTEYLHELVVVHRDTRQTRPAADVHRARAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ5</accession>
    <name>A0A7W7WUJ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane-anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022215">
        <property type="entry name" value="SteA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12555">
        <property type="entry name" value="TPPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="TPPK_C" evidence="6">
        <location>
            <begin position="336"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="394" mass="41426" checksum="92284D5D8B5EA462" modified="2021-06-02" version="1">MKLSGLLSRSNRELPGTSGLARVDRRTGDLLRRIGPGDIAVLDQVDLDRRTAEALVAAEVVGVVNASPSISGRFPNLGPEVLVAAGIPLVDDVGTAVLRVVKEGTKLRVHEGVVYAGDREVARGVEQTAERIADALIEAKAGMAAQLEAFSANTIEFLRRERTLILDGVGVPDVVVPIKDRQVLVVAGGTRHVDGLRRLRKYIREYRPVLIGVDIGADTLFACGFKPDVIVGDPDGIGTEALRAGSEVVVPAQTDGHAPGLERIQDLGIGAVTFPATGNAEDLALLLAEAHGATLVVTVGVQAGLREFLDRGHCGSNPSTFLTRLKLGARLVDGEAVAVLHRSRVSFGVIALLVLAAVVVMVAALWVSGVGQVYVDIAVDGVRALVDQVKGWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL2</accession>
    <name>A0A7W7WUL2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-B factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="46"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="29300" checksum="A52F95BA94D357E5" modified="2021-06-02" version="1">MTAPDGGTTRSTSGSQGDYDHLAPLFVELAGKEPGDPARDRLRDELVTRHLPVAKHIARRFGHRGEPYDDLVQVATVGLINAVDRFDPERGSDFLSFAVPTIMGEVRKYFRDSSWSVRMPRRLKELHLAINAGTARLAQSLGRAPTPSELAEHLGLTREEIHEGLAAGNAYHSASLDDLLVADDSSISLGSTLGGEDPEIEAIEQREALHPLLEKLPERERKIVVMRFFGNMTQTQIAQKVGISQMHVSRLLAKTLRQLRDGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL7</accession>
    <name>A0A7W7WUL7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="38"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="170" mass="17634" checksum="EE7ABD4536BDD528" modified="2021-06-02" version="1">MTPLVQRTQTDRPAHAAVQPDFQPDEEILTVTVCPAPPGAFVVAVHGEVDGSTTPLLRDRLLDLLRPTCPHLVVDLTDVSFFGAAGLTVLLAVGEAAETAGVSLFLVAGTRVVLRPLAITGLGELFDVCPDIAHARLRLRDVSAQTTGGSLDDDGTLPGPRAGPGTPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP6</accession>
    <name>A0A7W7WUP6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32790" checksum="075B6AD61B57AD3B" modified="2021-06-02" version="1">MIEVVGLTKVYQGRNAVDDLSFQVRPGVVTGFLGPNGAGKSTTMRLILGLDRPTSGSATVNGHAYRDFALPLREVGALLDARSAHPGRSARDHLRILATANGIPAVRVDEVLDLVGLHDVGRKRIKTFSLGMTQRFGLAVALLGDPPVLLLDEPLNGLDVEGVHWMRNLLREFAEEGRTVLVSSHLMSEVQGTAKRVVVIGGGRLIADTDTRTFIESTVRACVLVETPCADKLTATLESAGATVERAETHSLRVHGLSRRQVGELALGAGVVLYSLGDEGLSLEDAFLSATNRFVDYRTSGGEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ7</accession>
    <name>A0A7W7WUQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt/nickel transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031400734" evidence="6">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="7">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="9884" checksum="8E84B75C78DACB68" modified="2021-06-02" version="1">MKRFFLGFALVSLVLAGVVSYFASADPDGLDYVTEEHGIAEHARDHPLGGGPLADYAVGGDDRLTGVAGVVGVLVVLSVAFGLFRLLRKRTPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUS9</accession>
    <name>A0A7W7WUS9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Shikimate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="123"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="5">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="28232" checksum="8074C67722BEF035" modified="2021-06-02" version="1">MSRRAAVIGSPVAHSLSPVLHDAAFAALELDWTYDRVECAEDGVPDLVAGLGPEWVGLSVTMPDKRAALAVADVVEPRAALVGAANTLVRTGSGWRADCTDVDGVVGALRAACGFTSGTRAVLLGAGGTATAALVGLASVGVRSASLVVRSPERAVEAVECAGRAGVELDVVAWADADFAALASASDVLVSTVPPAAVEPVADALAQAPCVLDVIYHPWPTPLADAVGRRGRVLATGLDMLLHQAFGQSEWFTGRPAPRAAMRAALHAATGGVLPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV94</accession>
    <name>A0A7W7WV94_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="47566" checksum="26C3923E6DF19DF1" modified="2021-06-02" version="1">MTIADLVDRVSPILPDPVDELQVAAVLESQGVTDQAAADDYGEADVFALARRVFPLLPGREDDPPAPPADRRTRIDLLHGPLYLLPTLAYPAAFEVLGSAVAVRALVFATAFGWVWGAGASFVAYQLVGLDARGSATRTFLHLGWLGLGVGTLLSLPLLLFGGGLGVPLFVLAQLAVQQIVGVLLFHRRERVLAYAMLPAGIGGLGYLALSDERFAWPVLALGCVSVVLGMESARRSGRAHRDADGVRLPEPRVLVKNSLPGLAYATMCAALVLYVDARYVLGALDLAVAAAPLVLGMGVVELRANRLFEHADGLLREPLRPGEFHERMWRALLRELATCLVALGALALVLLAVLRSLGVLTSAGAFLVDGHVVLGGVFFLGFVLVRTGGAVLAPALLGGASLGCVTTAELVADPLTTDSLPRVFLATGIALSVLLLTALRRGVGQVRHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC5</accession>
    <name>A0A7W7WVC5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031356044" evidence="1">
        <location>
            <begin position="27"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35943" checksum="D212F50CEE9990C1" modified="2021-06-02" version="1">MILSRPTALLAAAVVLTACGAKVESAPPGETAPQEVTVVNCGREVTYPVPRRAVSYDVSGSEKVFALGLGPRLRGYVMNALGDPSIAGSPWKDQYASVERLGTSRVTKEILVEAKADWVIAGWNSGFSEERGITPKLLDQLGIRSYLHTETCWEFPDAKQDVNPIEALYTDLRNLGDIFQVRPRADELVKELQDRFAKVRATAPKDKPPVKVFVYDSGTDQPYTSGRHAAPNEIIAAAGGRNIFDTLEDGWGAVGWEPVVQSAPEVIVIVDWAGQTGQEKIDYLKGLPQLANVPAVRDNRFHILSYGDLVSGPRNAQGAESLAGYLRSIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL0</accession>
    <name>A0A7W7WVL0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031482863" evidence="6">
        <location>
            <begin position="31"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="216"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1108" mass="116349" checksum="5BF3F69B8C17ADE6" modified="2021-06-02" version="1">MNRERRPRGTGTFVAAVVVASALVAPEATARPAEADVSQPSGERHTITLVTGDRVDLYSSDDGQHNAVFTAAPGREHVGYTTRTVDGRFHLVPGDAAALIDADRLDAALFDLTGLVAAGYDDVGSPLLPLIVQYDPDAAGVQSTALPPGVTERFVLESINARAVWQPRDRAAAFWPSVAATAAVRKVWLSRRFQAVLDRSVPQVGALSAWAGGFDGTGVKVAVVDSGIDTAHPDLDDGKVVAAANFSTDPDAADRNGHGTHVASTVAGTGEASAVVRKGVAPGAKLLNAKALNARGLGSDAAVIEALEWAAAQGADVVNMSLGSLDPARGPDPLTMAVDAVSRTSGTLVVVAAGNQGERGTSTITSPGWADEALTVGAVDREDAVADFSSRGPRLGDHAIKPDLVAPGVDIVAARAEGTRGGPVVDERYQQLSGTSMATPHVAGAAAILAQQHPTYTNSELKGALISTARTATGVGVHDQGGGRLDVARAFAQRVHAVPGTLDLGYLRWPHPTPVTRNVTYTNTTTSEVASRLSLDVSKEDGTAPPAGMFTLGSPQVTVPAGGTASVAVSVDPTAGPAGRYEGYLVGTAGDVTVHTSVGVYVEPEVYDVTVTAVPRDGELDEVSQVVLWSPGSGTAVRSVSADKSTVTFRLPPGTYIAAGFLIKTEAGPGRRFEEVTFVGDPRFEVSGDTALTLDGRTANEIVVDTELPAVTVAATLGVHRAAGGREMSFHQVAPYRVRAYAAPTETVTDGEFEFLSRWDLMAPSDEGGAPPSYEYDLLLPEKQRVPSSLAYTIDRSNTAIVDTFYRADVEGEAGSDIRMPRRPYEADFGEHPRTVPRPSHRTYFVSADDTQWQHAVQPTRSGAEEFLGPFTAYKPGEVIREEALGRPALPGTTPSMTPSERTGDTFTFNVSPLVDSGGHRRLLPDSGEAHRTGLWANGELLDEGPVPPHRGWPMTVLPDPAVYRLLYTSEQSAPWAPYSTRIRTEWTIPSGRPADGTTDRVPLMRLDYRPALDDHNRAPGGAFGFPLHVGHVPGVHGAPVATVQGWASSDDGSTWEPMSLLDLGDGDYVARLRHPSSGAVSLRVVAADTAGNGIDQTVIRAYGVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA9</accession>
    <name>A0A7W7WWA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17344" checksum="E28794D8B71F8DB2" modified="2021-06-02" version="1">MSAVLLRPVSDADVPLFFAHQNDPHAVRMAAFTAADPRDAVAFAARWARIRTDPAMLARTVEFEHVVVGHVLRYAQFGEPEVGFWIAREHWGRGLASAALDAFLRLDPTRPLYARAAVDNLGSLRVLSKCGFVAVGEDVGFAEGRGADVEEFILRLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ7</accession>
    <name>A0A7W7WWJ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031284325" evidence="1">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10964" checksum="200ACD8002F2FCB7" modified="2021-06-02" version="1">MKIGKMFGALLAVLFAMTTLTTTQASAATYRWECRYVPPGHVYSMVRADQGCEPLYWVTLPENGLWSCIVPAGYTYTATRVNSNCRLGGSTTQYQLAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP0</accession>
    <name>A0A7W7WWP0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003948</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="918"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1018" mass="106836" checksum="8141AAF57E4FF648" modified="2021-06-02" version="1">MASEDELLAYLKRVVGELDRTRQRLAELEAGAAEPVAVVGMACRFPGGVVGPDDLWRMVVEERDAVADFPTDRGWDLDSLFDDDPERAGRSYTRRAAFLDGAGDFDAGFFGIPPREAPAVDPQQRLLLECSWEALERAGIDPKSLHGSETGVFMGLMQHDYAARLRSVPADLEGHLDLGSLAAVASGRISYTLGLRGPALTIDTACSSSLVALHLARRSLRAGETDLALVGAATLVFEPGVFVEFSRQRALAPDGRCKAFADGADGFGAGEGAAVVVLERLSDARRNGHPVLAVVRGSAVNQDGASSGLTAPHGPAQEQVIRRALADAGLDPGDVDVVEAHGTGTRLGDPIEAGALLATYGRDRTTPCLLGSVKSNLGHTQAAGGLAGVLKVVMAMRAGIVPRTLHVDTPTREVDWSAGALRVAAASVPWPETGRPRRAAVSAFAVAGTNAHVVFEQGDEPEPPPVPVPPIELPFALSAHSPAALRAQAARLRDHLDGRRPVDVAHSLLTTRAHLRHRAVLVARDHDTLRRDLDALAADRPVEAARGVAGGGRTAFVFPGQGSQWVGMAAGLARRSPVFATLLDECGEALAPHLGWSVSDLLRREDADFARVDVVQPALFAVMVALAGLWRAHGVRPDAVVGHSQGEIAAACVAGALSLADAAKVVAVRALALADLAAPGAMAWIASPVDEVSALITADVSVAAVNGPASTVVAGEPEAVGALLAHCASHGVRTSRLPVGYASHTMAVDVLADDLVARIGHITPKESEVPYYSSTTGTALDTRSLDAHYWFRNLRQVVRFDRAVRAMADDGHRLFVEASPHPVLGPSIVDAVPATAIATLRRDEGGPERFLAALGEAHAHGVEVDWTPVFAGLSPRRVDLPTYAFQHRRYWLDNSGVPAVSRVEVPEPVASAAPSGLAAVLDLVLGHTAVILGHVGPDGVDPDVAFRDLGFESLAAVRLRDRINAATGLRLPSTVVFEHPTPAALADLVCAELDGPALPADAAEITDDELFALLDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ4</accession>
    <name>A0A7W7WWQ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein/aryl carrier-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="915"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2266"/>
            <end position="2342"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="3630"/>
            <end position="3706"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="5360"/>
            <end position="5436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="866"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4194"/>
            <end position="4251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="4266"/>
            <end position="4292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="4215"/>
            <end position="4236"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2302"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="3666"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="5396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="5462" mass="562421" checksum="1E90EA8311395B20" modified="2021-06-02" version="1">[encoded data, 5462 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWS0</accession>
    <name>A0A7W7WWS0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="50"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27473" checksum="F64359FC0A4DE73E" modified="2021-06-02" version="1">MRVLRWVALLVASVLFLLPFVVLVRSGLGTGWSTVTALFTDTGLSFTRSLLNSTVVAVLQTAGQLVLCSMAGYGLARVPYRHASFVFYAVVATLMVPTAVTFLPAFVVVSSLGWVSDLRGLVVPGLFSALNVFLFRQYFVDFPAALEDAGRLDGLSRWGVFRRIVVPNSKGYFAAVAVIDFIASWNQFLWPLVIAQDSSTWTVQVALSGLLTSQNPKVTLLFAAAAVSIMPIVLVFVLLQRHLVRGATESGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX1</accession>
    <name>A0A7W7WWX1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="32527" checksum="0B0DEFBE96E602E2" modified="2021-06-02" version="1">MGSPVVVKAGRPSDRSTHSVVRARAMLESRSCAEAARSLIQVARTITAGDEENVLLLMELGYEAHRRAPRCADVADACAHIAIFLASHSAHRRAAMFALLARRTRSEAGDRFGEMSALRLAARVFRSADRLDRVLDCADAMDRLMNPECSPVLFASCLRAKGVLMREVGRPDAAIDHLDRARAILDPLPGPLARRTLALTLVSAGRTSWETGAYQAARRRFRSAATILSMVDQVGADEAHRMSQTMPGSPLAPSETLVDSDFGHPTWPDRRAAGVSTAVRTWNPRHLDEHLDVPLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK4</accession>
    <name>A0A7W7WXK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="21709" checksum="3D05299AA5D6F1E1" modified="2021-06-02" version="1">MSERIPLDLLDPATVRRRARGVALGGLLVAAAFGGLLGLLAGQTVGLITAAVFFVPLVLLSVSEARRRVWLEGHVLYVRAIGTRKVDLHTADQLDLLVTDVRGSRTVGMFVRGGGKAINLALAVYAGTGGREQGVLALRKVADVLAGRGDAPGLVFSELLVAQLRAEARGLAAADRPLYRLGSLAPAGRLAQKLTPDAVSRFVSTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXT0</accession>
    <name>A0A7W7WXT0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="37102" checksum="1C26D46F174BE06B" modified="2021-06-02" version="1">MDRLGDILEFTWKYLLHLTPWFLLAVVLGIVANLFALDILARRAFTKHGVLAIVATTAIGAFSPFCSFTVIPLIRRFLAVGVPLSAVMAFWVASPSMDPEIFGLSAAQLGMPIALARLLGALALSLAAGFIVLAFEKRGHLLDPLRKDVVEEAAAPSCRQVPVAAGAGDGPGAPASDDTRPSACDAAVRPEPTSCGATPTVVDDGAPWWPMVRKNLREANPVALLKEAWGDTIRLGKWFLLALIADAVIVFYLPGEVIANTVGGGLLSILVAALVSFPLYVNGVGAIPIVDGLLIKGMDAGAAVTFLLAGAVSTIPAMAAVRSIVNWRVFSVYLGVGFFGSVIIGYLSWLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY9</accession>
    <name>A0A7W7WXY9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipooligosaccharide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="33602" checksum="CCE694CCB0C71C20" modified="2021-06-02" version="1">MTTTLVEAKALTKHFGTFEAVRGIDVQVRAGEAFGFLGPNGAGKSSTVRMVSCVSPRSGGDLTVFGLDPERDGPSIRARLGVVPQQDNLDNELTVRQNLEIYGRYFGLSRSTVRAKAAELLEFAQLTDKADAEVDSLSGGMKRRLTIARSLVNEPELLLLDEPTTGLDPQARHLLWDRLFRLKQSGVTLIITTHYMDEAEQLCDRLVVMDGGLIAAEGSPADLIRRYSTREVLELRFPPDGQDPDLVDGLADRVEVLPDRLLLYTDDGEATLAAVHSRGVRPTSSLVRRSSLEDVFLRLTGRTLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ6</accession>
    <name>A0A7W7WXZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diamine N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.57</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.57" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15953" checksum="88A1B4080F89CBC0" modified="2021-06-02" version="1">MNLEPVTKDNYDAVVALEVHEEQRLFVATNLKSIADAWVHRPTLQPLALLNGGELVGFTLLDRAGPDVLGIARFMIDRRAQGRGLGRKGLAAVAEVARSEGRSRLRLGVVPGNAVAHGLYAAFGFVETGEVEKGEIVMVHDLAPAHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ9</accession>
    <name>A0A7W7WYJ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041674">
        <property type="entry name" value="TetR_C_22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17928">
        <property type="entry name" value="TetR_C_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25994" checksum="94598E57FFCF4D31" modified="2021-06-02" version="1">MARLLQICSLGLPARIHQDVLVPENPAENRLAKVMRRQPVQQRGAATVTAIVDACATLLNEYDYDDITTARIVELAGVPIGSFYQYFPDKRSVVHALALRGMEEYLGRVESLLTAEPLADWRDAARRVVAVYLRMVAELPGFGRVRFSDLLDGHRLDSSVDQYELMAERLRDLFVDRYAVRGSAPVTLTFRMAAQAADAMFKLAARVDAEERPLVLSTADGVILKMLSGVFDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN1</accession>
    <name>A0A7W7WYN1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8611" checksum="003A72C918986413" modified="2021-06-02" version="1">MEVKVDVRYLRTEPTMAFPRGRLLAVRGGRLYVLAPDGWDPVGGVRPEGARPMSRAEAGQWCGFEGRDTAVLDAVPAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR4</accession>
    <name>A0A7W7WYR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative RDD family membrane protein YckC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="178"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="37489" checksum="1A289A0089ACCAC6" modified="2021-06-02" version="1">MNAPQPPGNQHFGGNNEQGQGAQQPPNADATQVVPGASQPPAFPPPEATQVVPSGPQPVANPDATQVVPGGGAVQPPQSNPYGQPPQQPPSGGFPAQQPPAYGQQPPQYGQPQQPPAYGQPPQAPPSPYGQPQQPGYAAAPPSNPFGQPAQPGFPGAQPAGWGAAPAGYGAPPPPGGYAEWGTRLISGLIDFAAPGAVMYVLVLIGGLTGDLTISFIISSVAYIAVIAYFIYNMGYLQGTTGQSIGKRIAKTRLISEETGQPIGFGMAIVRHLCHIVDGLPCYAGFFAPLWEVKKQTWADKIMKTVVVNYATPAGPLPVPGQQQPYGYGQQPGYGQQAQQPGYGQQPQQGYGQQQPPQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS4</accession>
    <name>A0A7W7WYS4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="35689" checksum="31F6F9715571D756" modified="2021-06-02" version="1">MTVDPVLEVEDLRVEFRTRDGVARVLNGVSYHVGAGETLAVLGESGSGKSVTAQAVMGILDTPPAFVTGGSVRFHGEELLTASADRRREVRAEGIAMIFQDALSALNPVFTVGFQIEEQLRLRRGMSRSEARKRAVELLDLVKIPHARFRVRDYPHQFSGGMRQRVMIAMALALDPEVLIADEPTTALDVTVQAQIMDLLAEIQRERRMGLVLITHDLGVVAEVADRIVVMYAGRIVEEADAFALFRSPGHPYTAALMRSLPRLDDKGSTLETIKGLPPSLLRIPSGCPFHPRCPRAEDRCLAEVPPPLDLGGRTSACHFAPEVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX5</accession>
    <name>A0A7W7WYX5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_006348</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="480" mass="54288" checksum="7BC9A47BBCE86A8B" modified="2021-06-02" version="1">MTERNTTDNAGIPVGSDDHSLTLGPNGPILLQDHYLIEKNAQFNRERVPERVVHAKGGGAFGRFETTEDVSRYTKAALFQPGVKTETLLRFSTVAGELGSPDTWRDPRGFALKFYTTEGNYDLVGNNTPVFFLRDPIKFPDFIRSQKRRVDTGRRDHDMQWDFWTLQPQTAHQVAWLMGDRGIPKTWRHQNGYGSHTYLWENAAGERFWVKYHFKTDQGIETLTSDEAAVIAGEDADAHRADLWHAIERGEFPSWTLHVQVMPYADAATYRFNPFDLTKVWPHGDYPLIKVGKLVLDRNPADHFAEIEQAAFEPSNLVPGIGTSPDKMLIGRLFAYPDAHRYRIGPNYAQLPVNRPKSPVHSYAKDGPMRYTNAADPVYAPNSYGGPHASPKADDHASTYGVEQRVVREAYTLHAEDDDFGQAGTLVREVFDDAARERLVETVVAHVSKGVSEPVRDRVFEYWRNIDKETGDRIAAAFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ99</accession>
    <name>A0A7W7WZ99_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4773" checksum="BA76E14DCC3B3A97" modified="2021-06-02" version="1">MIDDQLPVEIFEDDAAPIPVEISAFASTEDKSPQNHMSNQEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZX9</accession>
    <name>A0A7W7WZX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phytase</fullName>
            <ecNumber evidence="3">3.1.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:3-phytase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030813536" evidence="1">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="39831" checksum="77EA877A1BDB8248" modified="2021-06-02" version="1">MRLRTCVAVVVLALGVTAVPATAAPAGVRYLGQAVVPHKLQFRGTTVGGLSGIDRDPFTGRYVLISDDRGYTEPPRFYTANVRVTTSGVDSVEITDVRTLKRPDGSTYPSPAVDTANAIDPEELRVDPWTGGYWWAQEGDRPTGKPLVQPSIRQAGRDGAHVADFTLPRNYAIEPTTGPRRNQALEALTFSSAGFLVTSVVEGPLLQDGDVPTVDRGALTRLTVQTRGGDVVAQYAYPLEKLFAVPEPGPWGPDTGVPAILADPYTPGKYLTLERQWVPGAGYDVRIFEISVFGATDVRRLDTLNANVRPVHKKLVANLKDLPLPVVDNVEGITWGSVLPTGERTLLLVSDDNFSAEEFTRFIAVALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X035</accession>
    <name>A0A7W7X035_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="31167" checksum="23CDBB974A8A05C3" modified="2021-06-02" version="1">MARTRHVIAVDVGGTETKAALVTGTSQEVQAVKQQRCSTARGDADAVVDQVASLVDELRAASEHPIDAIGLVVPGIVDEIEGIGVYSANLGWQDYPFVRTTEERTGYRTAFGHDVRAGGLAEHRMGNARGLENAVIIPIGTGIAGALLIDGRVRSAPGEIGHVDVGHGDPCGCGQTGCVEARASSAAIARRFTERTGKPVRGAADVAALVRAGDADAGAVWHEAVDALARGILLVAALLGPEAVVLGGGLALAGDLLTEPLRDRLDGLITFQRKPDLRLAALGDEAGCLGAALLAIDMLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXW0</accession>
    <name>A0A7W7SXW0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">F4559_000324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="200"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="227"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4962965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="519" mass="56100" checksum="34046DB435260369" modified="2021-06-02" version="1">MADSNNRPVLVVDFGAQYAQLIARRVREAQVYSEVVPHTATADELLAKDPAAIVLSGGPSSVYEPGAPQVDPKLFELDVPVFGICYGFQAMARALGGTVAHTGTREYGRTELTVGGTAGVLHDDLPAGHPVWMSHGDCVTEAPEGFTVTAGSEGAPVAAFEDRERRFAGVQYHPEVGHSPHGQEVLRRFLHDIAGIRPQWTTSSIVDEQVALIKKQVGDGKAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVERDYVAATGVKLVTVDARERFLGALAGVTDPERKRKIIGREFIRVFEQAERDLKAEGDYRFLVQGTLYPDVVESGGGAGTANIKSHHNVGGLPDDLQFELVEPLRALFKDEVRRVGTELGLPETIVQRQPFPGPGLGIRIIGEVTAERLEILRKADAIAREELTSAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPVVLRPVSSEDAMTADWTRLPYDVLERISTRITNEVAEVNRVVLDVTSKPPGTIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY44</accession>
    <name>A0A7W7SY44_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="5">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024067">
        <property type="entry name" value="Me-malonyl-CoA_mutase_sm_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="4">
        <location>
            <begin position="43"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="584" mass="61909" checksum="0CECA5EC9C7A668F" modified="2021-06-02" version="1">MMDPIGELPLAADFATPDREQWRELVLGVLAKSGADYSTLESTTYDGIRVHPLYTAADTAPDGGLPGTTPFTRGGRTQGGWDVRQLHRVPDREAVLADLENGATSLWLKIPAESLAPVLAEVYLDLAPVVVDGGSDFLATGREILGIWESAPGEVHGNVGADPLGVFVRTRREPDFAALTDLVRRAERFPAVRVAVVDGLPFHEAGGSDAEELGASLAVAVAYLRHLVDAGVPAGKAVRLLEFRYAATADQFLTIAKFRAARRLWARVTGVVDAPAPQVQHAVTSPAMTTRRDPWVNMLRTTVACFGAGLGGADSVTVLPFDHAIGLPDDFSRRIARNTQSLLIEESRLGGVVDPAGGSWYVERLTDDLAHAAWAWFREIEAAGGLPQAFDLVEERIAATWARRAANLADRTDAITGVSEFPNPTETPVVRTPAPEEPGGGLPRVRYAQAFEALRDAAEVSPTRPAVFLATLGPVAAHTARAGFAANLFQAGGIDTPTAGATTGVDDVVARFRESGARIACLCGSEKSYAELAEPVADALRAAGAERVLLAGKESTARVDGYVFTGCPALDVLEQTFDALGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYI3</accession>
    <name>A0A7W7SYI3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="8144" checksum="2E4A767C52325424" modified="2021-06-02" version="1">MTSYLAALAPETAADAETTAGSFGNAQVYQLRLQLMANEQLKELAAERQTSPQALATEWVMQRLEWEARQRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK8</accession>
    <name>A0A7W7SYK8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_000628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="184"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="452" mass="48101" checksum="442A3D1B57F171A4" modified="2021-06-02" version="1">MAISVFDLFSVGIGPSSSHTVGPMRAAALFAARLPLDRVDRVHVELFGSLGATGHGHGSPKAVLLGLEGHRPEEIDPTAADDRVAVIRESKRLSLGGRREIAFAEDTDLVMHRRKSLPLHPNGMRFAAYGCGEVVDEAVYYSVGGGFVVDETASGTDRIKADATRLPHPFRSGDELLARTRETGAPISELMLANERVWRPEAEIRSSLLHIWQVMQDCVERGCTRTGVLPGGLKVRRRAAELRDRLASEHFATDPLRVTDWVTLFALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYARFVPGASDDGVVRFLLTAGAIGVLFKENASISGAEVGCQGEVGSACSMAAGGLAEVLGGTPEQVENAAEIAMEHNLGLTCDPIGGLVQIPCIERNALAAIKAITAARMALRGDGSHFVSLDKVIKTMRETGRDMKVKYKETARGGLAVNVIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYM9</accession>
    <name>A0A7W7SYM9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11509" checksum="5D3C8928E0EF2517" modified="2021-06-02" version="1">MADRLSTAEQVFAAGTGGPAGAVIVRTPGCTRPCSAEFDRYAPPTSIHRAVECVADTVTSWDPRADDPGKACVHPLRRRGTVVLSVPGGAQRARTCRRSVGHREVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ1</accession>
    <name>A0A7W7SYQ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="25115" checksum="0CC0CBA8EBBC67E9" modified="2021-06-02" version="1">MHVLRYAVGTDPGLHRATNEDSVHVSDRLLAVADGMGGHAFGEVASNIAVTVLDEVDVDADDPHSALAAATHEIAVRLTDLAEENFDMRGMGTTLTALLWDGEKFAVCHIGDSRCYLVRDGGLTQVTRDHTMVQAMVDDGRMAAEQAAEHPGRSMLMRALQAGSEHDPDLFDQDVRAGDRFLLCSDGLSDVVPAEEIGRLLTADPDRDVTVRSLIDAANAAGGPDNITCLVIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR7</accession>
    <name>A0A7W7SYR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="72" mass="7981" checksum="F558E0CDCF031B74" modified="2021-06-02" version="1">MAFEQREWLLRCTDKDESLATCSIEVSAGRVEVWAQDRAMIGLSGTEIVHFRTALDDAIARAGRDRAEVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU0</accession>
    <name>A0A7W7SYU0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="9801" checksum="B97B18A81172CBBA" modified="2021-06-02" version="1">MENAETDARRQLVLGQAPALYGLVDDGPGVGAVVGWVLEFPGRAVLVDQAGWHSVHATVEDAELLANVTEGIGVHVVAAGPGVHRGLGRVACTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ17</accession>
    <name>A0A7W7SZ17_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-type ATPase subunit c</fullName>
            <shortName evidence="10">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpE</name>
        <name evidence="12" type="ORF">F4559_000938</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="11">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="10">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8217" checksum="D1078D61CD9F919C" modified="2021-06-02" version="1">MSALVLAQDAAASINPGLAAIGYGLAAIGPGIGVGLIFSSVISGTARQPEARGVLLGLAWTTFAIVEVLALIGFVVYFIATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ62</accession>
    <name>A0A7W7SZ62_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13614" checksum="B6D372A7AD7AC61D" modified="2021-06-02" version="1">MSCIVGRPLRPVSWLAVPVLFGTAVLGLTGLGAVLLGDPRPITLPSALFGASAAMGFVTAPLVSWRRYRPPRWAYPAAFLVVGVFADGVQVPVGLSCLIGLPAVAFLVHRYFVERRLTAESAHQSGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE9</accession>
    <name>A0A7W7SZE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="38" mass="4125" checksum="2448AC249B231B34" modified="2021-06-02" version="1">MTGRHHIHHTDRARHACAVLLFAVAIAGLWAVVLGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZK9</accession>
    <name>A0A7W7SZK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="22915" checksum="0705CAFE01B87C9D" modified="2021-06-02" version="1">MTLSPTPRSTVARGKKRAVTSRAALYDVLDAGLVCHLAVVVDGAPVVLPTGYGRDGDTLYLHGSTGARTMREASSGMPVCVSVTLVDGVVYARSAFSHSMNYRSAVVHGVAERITDPARAEHGLRVLTDHLAPGSWDYSRRPTPKELAATAVLALDLTEASVKIRTGPPGDEPADVAENSRWAGVLPLHRSWGTPESDPTLVGPWEIPPHVTHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T009</accession>
    <name>A0A7W7T009_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
            <ecNumber evidence="3">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="243"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="35585" checksum="DDD496BDEB6930FF" modified="2021-06-02" version="1">MNHHGPVRPDDVLAELHAVAGRIAANVERVLVGKPEVVRIALVTLLAEGHLLVEDVPGVGKTSLAKALARSIDCTVSRLQFTPDLLPSDVTGSSIYNRQDNDFEFRPGPIFANIVVGDEINRASPKTQSALLECMEEQQVTVDGNTYQLAAPFMVIATQNPIEMEGTYALPEAQRDRFTARVSIGYPDPQAELAMVDEHAGSNPLADLRPVSTGDQVLKLVQAVRRVHLSPDIRRYAVELVGATRRLPELRLGASPRSTLQLVRAARAQAALSGRDFVVPDDIHVVAVPVLAHRLVLTAEAQAARRSSADLVRGLLQRVPVPQHLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T020</accession>
    <name>A0A7W7T020_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15242" checksum="C4AD1945F65F0E79" modified="2021-06-02" version="1">MTTPGGMRGIDQNLAPVPRRPAMIHLAFALWLATALLWPLGTVLIVVAEPGFDPVGLAMPLFASVCVAVAIGWGAFLVRAGSRSGRIGVSLGVLLLGFILVGQIVGAARGDSVAVEWIVLPTRLLLSIAAVVASFGPGTRDWYREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T074</accession>
    <name>A0A7W7T074_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisF</name>
        <name evidence="11" type="ORF">F4559_001523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="27164" checksum="76044B677ADA3881" modified="2021-06-02" version="1">MSVAVRVIPCLDVDRGRVVKGVNFTDLVDAGDPVELARLYDAEGADELTFLDVTASSGDRETTFDVVRRTAEQVFIPLTVGGGVRSVEDVDKLLRAGADKVGVNTAAILRPELLGELSRRFGAQCIVLSVDARRVPADGQPTPSGFEVTTHGGRKGTGIDAVEWAARGQELGVGEILLNSMDADGTKNGFDHELIRRVRAVVDVPLIASGGAGTVEHFPPAVEAGADAVLAASVFHFGTLRIAEVKDELRRAGVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H5</accession>
    <name>A0A7W7T0H5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031466761" evidence="1">
        <location>
            <begin position="25"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="20438" checksum="5610E038E87D44B3" modified="2021-06-02" version="1">MRSLLVLVALLAAGCAAPGGVVTGDRPPNVGRAELTVLDDAASISVRATDLDGRLFRTSGPVPHAVVEHGVVKVSCTGSGDIELDTGVVWSVRVAGGASAQTVDLRGARVGAVTFEAGASRIDLRLPSSTAVVPVRVVAGASEFVLHAPDGARITLGGGASQVVLDGVARDDVAAGTVLTTGDPVRYEVTVEAGVSRLIVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T0</accession>
    <name>A0A7W7T0T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030781208" evidence="2">
        <location>
            <begin position="19"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="636" mass="67089" checksum="06A657DC44B3691E" modified="2021-06-02" version="1">MNRKAALIAGAVTALVLAATLVPDTGGDPARHLLDRARSATTIEDRLLDTLRAYRTRDRLDTRSDLRGLARELRFADRFVPDHATTNPSGTRIAHHDEDGNLSGIVDVGGPGAIELPLRGGRHAAWLGDDRIATVRDGRVLVHDQAGQLLREAVADPDTLVGDWSGRFLAFTTPAGRPRVIGLDGSDVTLPTTATLLGVLPSGEAILADRTDKFAMSTTGTRDLPDDLPVDPTRSRPTITKCDHSGLTRFDTTTGARLGSVPGQPCTTGAFTEDGTEWATVEGTALALGDTATGTVTRRVEIPDQAGLISVEPEPGGHRVVLDDHGTALVLRIPPPDGLDRAFADAHRAAVTPDGALVVLLWRDGRIEVWDRGTRRRLNATTTRFPAGDRVEFALSPDSRALAARTVDHVGLWTLPGLAPTTVDAVGTPAFLDDTRLVVSGEDTTVWERGTRLGPPIHATAPYAAADGDDLVLVTAAGSARTFKIGDGSGGAGFEVGRTTAVALADGTLAVADDHTVRIHDLRTGEQERRTTLPDDTVVSGLVSADDEVTITLDGTLDVSWRWNVLWGLPALIGRGTESLEDVPGPAVPGYAVEGVGVESADPAVWHDALCGVVHRSGLADRPHDLPAGAFADEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T135</accession>
    <name>A0A7W7T135_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrite reductase/ring-hydroxylating ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030970895" evidence="5">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="65"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="15528" checksum="62D00F3919A3F47B" modified="2021-06-02" version="1">MTTTPTNDGLSRRRMLCGVLAALAVPAGLAACSDSPTTSSGPGTTPGTTTKAGDATTKPTAAGGSGIVALADVPDGGGVVVESDGRPLVLVRSGDTVKAFDATCPHQLQKVAPPVGDVITCPAHGSRFKATDGSRIDGPTPSGLDAVPVKVAAGQVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A7</accession>
    <name>A0A7W7T1A7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Murein DD-endopeptidase MepM/ murein hydrolase activator NlpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="26424" checksum="FCB58676D9FAF886" modified="2021-06-02" version="1">MEDDRSAVTGRVAAAVVAAGTLATTVGVANGFGSTGPTIIPLAAGADLALAVTGQPAATQSPQTVHAVSPGLEAAKLMRSEGLVARQHVDQAIKHASDGYTARQAELKRKQEAEEAERARIAAEEEAKRPKAVKPAQGTFTSGFGGRWGTTHYGVDIANSIGTPILSAMEGTVVEAGPASGFGLWVRVQHADGTITVYGHVNEILVAQGQHVAAGAQIATMGNRGQSTGPHLHFEVWAGGSQKIDPVGWLAERGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1D3</accession>
    <name>A0A7W7T1D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU (Regulator of sigma subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="43097" checksum="EB4234C3251931C0" modified="2021-06-02" version="1">MAGLSGSRSSADRITVLLVEDDEGDAVLVEALLDEVGADVDLLRARTLREAARMVGRVDCVLLDLGLPDTTGLDGLTRLLDRAAPAAIIVLTGMHDEGQGILAVTAGAEDYLVKGQVDGRGLLRGIRYAVGRKRVEETQRQLRDEKLLAAEKTRLERGLLPSPIMHGDDLGWAHRYRPGGSRMLLGGDFYDVVRTDDGTLHVLIGDVCGHGPDEAAIGVFLRIAWRALVLAGQEPSRVLRTLHEILEHERHQPGLFTTACMLTVSPDRRWARVYLAGHPEPMLIVGGRVVELPRDRAGLPLGVLPDSSWDGLDVPLPPGWSLLLYTDGLVEGRVIGDVERLGSERLIDLIHDITRHGSDWDPEALMDELIDRVERLNGGELDDDMAVLLISDRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F3</accession>
    <name>A0A7W7T1F3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="20354" checksum="62FE0BB3E08D95F3" modified="2021-06-02" version="1">MDPQRERSWPDVDVEDELIRRLYQEFGGALLGHAMRLTGNDRQWAEDIVQETLVRAWRNAEKLERDPVLLRSWLFTVARRLVIDDRRKRSVRPQESELTPSDEAPVRDEADRTLAAIVVAEALNALTEEHREAILETYLRDRTVGEAAAVLGVPPGTVKSRVYYALRALRRALQDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K7</accession>
    <name>A0A7W7T1K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10659" checksum="76F96C17B548950C" modified="2021-06-02" version="1">MLNTPVGRFRLLAFAEAVSWAGLLLGMFFKYVVVGNEIGVKVFGPIHGAIFVGYVLVTLMMAQKWSKGVLFVALLASIPPFGTVLFERWAQRQGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L0</accession>
    <name>A0A7W7T1L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD superfamily hydrolase (TIGR01457 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="26588" checksum="314E8D745F0B61FB" modified="2021-06-02" version="1">MLLDRYDALLLDLDGTVYRGREAVPGAVDAVAHARAHGIGIRFVTNNASRSSSDVAGHLAELGFGASPDEVSTSAQAGAAMLVDHVPAGATVLVLGTTALVDGVRARGFVPTTEAAGAAAVVQGLSQDLGWRELAEACVAIRAGAVWVACNVDYTLPTERGLLPGNGSLVAALRAATGAEPSVAGKPATPLLDQAAKSLGAQRPLVVGDRLDTDIAGAVNAGMDSLLVLTGVSTRAEADALPPEARPTHIAADLSVLASATVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L1</accession>
    <name>A0A7W7T1L1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein F4559_002256</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="26950" checksum="4BDF0779ADA2F586" modified="2021-06-02" version="1">MSGHSKWATTKHKKAAIDAKRGKLFARLIKNIEVAARTGGGDPDGNPTLYDAIQKARKNSVPLDNIERARKRGGGEEAGGADWQTIMYEGYGPNGVAVLVECLTDNRNRAASEVRTAMTRNGGSMADPGSVSYMFTRKGVVILPKNDVAEDDVLMAVLDAGAEEVNDLGENYEIVSEATDLVAVRKALQEAGYDYESADANFLPSVSVQLEAEGARKIFKLIDALEDCDDVQNVFANFDVSDDVMAEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L5</accession>
    <name>A0A7W7T1L5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="22429" checksum="471C5AD0CE1FDA52" modified="2021-06-02" version="1">MPRVSQDHLDARRRQILDGARVCFARFGYEGATVRRLEEATGLSRGAIFHHFRDKESLFLALAEDDALRMAEVVAEQGLVQVMRDLLVAPEPTGTEHPGDWLGTRLEVSRRLRTDPEFRARWAERSRGLTDATRQRLLRQREVGNLRDDVDVDVLTSFLELVLEGLVSHLAMGLPADDLEPVLDLVEESVRRHRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L6</accession>
    <name>A0A7W7T1L6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="834" mass="91148" checksum="F0880886E5F6183D" modified="2021-06-02" version="1">MRALRRFTVRASLPEPLQALGTLATNLRWTWHPPTQDLFASVDPEIWARSADPLRLLSDVAPERLEALAADGRFLADLRAIATDLDEYTTGPRWFQHRGADERLPAAIGYFSMEFGVTEALPNYSGGLGVLAGDHLKAASDLGVPLIAVGLLYRSGYFRQALSLDGWQVEHYPVLDPRGLPLELLTDDAGGPLLVDVAMPGERVLRAKVWKARVGRIPLLLLDSDVEENDEDLRGVTDRLYGGDQDHRIRQEILAGIGGVRAVRAYCDLTGHPAPEVFHTNEGHAGFLGLERVRELVTGEGLDFDQALAAVRAGTVFTTHTPVPAGIDRFPVDLVQHYFGDGTLLPGVNTQRVLALGAEENPGLFNMAHMGLRLAQRANGVSRLHGEVSRDMFRGLWPGFDVTEVPIRSVTNGVHGPTWAATEMSALPADLGEVTDARLWELRSTLRGRLVDEVRKRTRASWLQRGASALELGWTSSVFDPSVLTVGFARRVPTYKRLTLMLRDVERLRALLLHPERPVQLVVAGKSHPADDGGKALIQQIVRFADDAGVRHRIVFLPDYDMSMARYLYWGCDVWLNNPMRPLEACGTSGMKSALNGGLNLSIRDGWWDELYDGSNGWAIPTADGITDPTRRDDLEAAALYDLLGNQVAPLFYDRDADGVPTRWLSMVRHTLSTLGPAVQASRMVVEYVETLYAPAASSASSVVGEGFRGAKELAAYRQRLRSAWTRVRVLDSELSVDGSAVPLLGTSVDVRAHVELAGLEPSEVDVQVVLGKVGDSDELYDVVTHPMSYGADGSYRASVSLPHAGAVGYTVRVLPRHDLLATSAELGRVVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1N1</accession>
    <name>A0A7W7T1N1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="491" mass="51974" checksum="1BA181B8A8EDD163" modified="2021-06-02" version="1">MSYPGGGGGGQWPPQNNPYGQQPQQPGGYPQQGYPQQQPQQGGYPQTGPQGFPQQPYGQQQHQPYGQQQPYGQQFGQQPFGYGEPPKKKRTGVIVTSIIVVVLLAAGAAGTFWALRSSDSVASGSENPTTAATNLLSALGSGDVIGIMNGLAPAEAKLSKDYVEATVSEGKRLEIFKKDADPNKLSGVQIKSEGIKFDEAAAEKVNDHLTINKVVEGKITVTSDVKQIPLTEKLTKALGAKLDAAPETDTLDFAEQKDKRKGKPIGIATIKVDGEWYPSLFYTIANAALEDEDLKWPAQGIAPAGAGSAGDAAKQLVTAALDGDVKKVISLLPPDEMGVLQDVGPVLLDQMGRVGSTGAKLVELETDTKDVTGGVLVTVKKVVVQVQGETVEVTRSGDCYTAKADGQTQKLCADEIAQLVEQQGGRDVPAAAIDVIARVGAQVLKDGIGVVTTEVDGKWYVSPFRTYSEVVLTLLRGLQPKDIDELLKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P9</accession>
    <name>A0A7W7T1P9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase (TIGR01509 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23469" checksum="A56BDC177687E6DA" modified="2021-06-02" version="1">MVEAVLWDMDGTLLDSEKLWDIPLAEFVATLGAELSAATREAMVGSNMATTMRMLYAEAGLDPTPAEIAEGSDWIRRRTEEVFREGLPWRPGAREALRDVRASGVPMALVTSTERALTEVALDTLGRDLFDVTVCGDEVDGLNKPLPEPYLKAARHLGVEPARCVAVEDSPTGATAAVAAGCVVLVVPCDVPVPSGERRVFRDSLVGVDLTTLARVLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T236</accession>
    <name>A0A7W7T236_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="9">
        <location>
            <begin position="7"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="45468" checksum="71EE462D475D6301" modified="2021-06-02" version="1">MDTGDTAWLLTSSALVLLMTPGLAFFYGGMVRAKSVLNMMMMSLGAIGVVGVLWVLVGYSATFGTDVGGGLLGKPFEFFGLDGLLGKDAVTGTVPTTVFVAFQAMFAIITVALISGAIADRARFGPWLLFAGLWSIVVYFPVAHWVFDFDGKDTSGAVVDPGGWIANKLAAIDFAGGTAVHINAGAAGLALALVLGKRVGWPKDRMKPHSLPLVVLGAGLLFFGWFGFNSGSAVGANATAGVTFVNTLVATSAAMLAWLVVERVRDGHATTLGAASGIVAGLVAITPACSAVTPLGAIGVGAITGALCALAVGLKYRYGFDDSLDVVGVHLVGGLSGTILIGFFASSAAPAGIDGLFYGGGVDQLWRQAVGAGAVLAYSFVLSLALGWLVKITVGFRLDKEAEVDGIDEAEHAESAYEHGVLTGSRGTARPSVAAGAAAVLEGSTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T262</accession>
    <name>A0A7W7T262_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="463" mass="51008" checksum="2BCA7E1460E79881" modified="2021-06-02" version="1">MKLNRQCRDCGANLAADNRSRLCSACGRRDVQVDRAPEVPAKFWATPEFREAFASRHFGRIMKVYRHAHDPVITQSRLAGWLDLSQSHVSNLESDHAVAPSDLVRLERWARALRVPQALLWFRLSGSSSVARGKRQGRPFGWFAVSEPPTVMDRTVELADVDMLRAMTRMFRELDNRFGGGHARSTVGQYLVGEVVPMLRAGRFRDGVRRELFGAVAEMNHLAGWMAYDVGDASAGRKHLRVALRLSNEVGDDAHAAEMLAGLSHHAAFSRSPLVAVDLARGARDSAARTGIGVLQAEAAVMEAHGLALLRDAKGTLSALRDAETSFEGAEGESAPEWLRYFDAAYLAAKFAHCFRDLGRSDEAERFARRSLEMAAGFDRGRLFNTALLASILADQRRIEEACEAGRAALQMAGNLNSVRTVAYLADVAARLKPFADVPAVTELFAEMRAMGIVTSPEREYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2P9</accession>
    <name>A0A7W7T2P9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CRISPR-associated helicase Cas3/CRISPR-associated endonuclease Cas3-HD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041372">
        <property type="entry name" value="Cas3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF5">
        <property type="entry name" value="PTHR47959:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18395">
        <property type="entry name" value="Cas3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="HD_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="911" mass="99059" checksum="052D6A9F2F9E13A5" modified="2021-06-02" version="1">MPVDLRWVWAKSVMDDHGRPTHWLPLQQHLDDAAGVAARLVDHWVSPQVLGRIAKDLGGDVDAVRELACWLARVHDVAKASCAFAVQVPLLADRMRDAGIVANPMLMTHPDRSRAHHTVVGYLAVRDFLAAEVGPVFADQMASVVAAHHGVPPERSTLAEVAGLTELIGGGVWQEAREFFLRRASEGVDWSRYQDIRLSMPSQVLLTAIVILADWIASNADYFPLLEAHEPPRDLDTAARVDHAWKRLALPRRWRASPVSSNVDAAFSERFAIPGGVVRPVQAAAVEVAATQSVPGLVIVEAPMGVGKTEAALLAAEELAARSGADGVFMALPTQATTDAMFDRVRSWVEALPGRDGSVSVTLAHGKASLNDTFTGLVRDGWFTSVGEDGEHDESAVVAHRWLSGRKKGVLASFVVGTIDQVLFAGLKSRHLMLRHLALAGKVVVIDEVHAYDVYMSQYLERVLHWLGAYGVPVVLLSATLPAARRVRLVAAYDGTPAPAVDGYPLILASGGTAPKVLPLPGNGTTVALDRLSDDIEQVVTFLREHLREGGCAVVVRNTVGRVQATAERLEQEFGVEHVTVNHSQFLSCDRARIDRELLRRFGREGERPALHIVVASQVVEQSLDVDFDLMVTDLAPMDLVLQRLGRLHRHPRKRPEPVTTARCAVVGVEDWAAEPVRAVAGSRAVYGEHLLLRSVALIVERDKVALPQDIAPLVQRAYDEDPVGPESWQSALARAKKRADDDEVRRVAAARTFLLDKVGSSRKSLIGWVRAGVGDADDGREGLAQVRDGGESLEVLVVQQDRHGGLHTPQWIDRGGGDPVPTDLPIEPPQERVVAACSLRLPRALSNPGVDLAVISALEKNCFPSFHSSPLLKGQLVLVLDVNGEADIGHGDVGFHVRYDPRRGLVHERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T5</accession>
    <name>A0A7W7T2T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="27"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="21569" checksum="20A82AEF6C7C9E01" modified="2021-06-02" version="1">MQIRARAVGVTGAHGPLLEPTSLVVPPGTAVLVAGDPGTGHTALALVLAGRLRPTSGQVWPDPADLRRHVVPVDLPDVNEPEASLTLAGVVGEELAVNGLPSGRRAVADWLADRDADAYLKHRFDRVPPAVRCAVTLELAAGRPDAAVLVLDSPDRYHGDPAGWWALARAHVTPDRSVVVLCATTSAAALDVPAVRIGDHTTDGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W1</accession>
    <name>A0A7W7T2W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase-like metal-dependent hydrolase (Beta-lactamase superfamily II)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24249" checksum="CFB5577AB4A1C470" modified="2021-06-02" version="1">MDVLDDYTGHVAPDGPATRRTLADLTITKVSVGPMDNNAYLLVCRESGEALLIDAAADPARLSDLLGHSPDRPRLKTVVTTHRHADHWGALGAVAGAHGANTVAHPLDAEVLPVPPDHLATHGDTVQVGRVPLTVIHLRGHTPGSIALLYRDPSGHPHLFTGDSLFPGGVGKTGSPEDFHSLLDDVSSRIFDELPDETWFYPGHGDDSILGHERPHLDEWRSRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T302</accession>
    <name>A0A7W7T302_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="27399" checksum="A911EDDA138EAC35" modified="2021-06-02" version="1">MTSAPTPSDDWRRQLTRAFGILLDRPLSEYPADASYGAFLDGNHIDEFDYNRAPEWVRPAVLDGTEPLELEIALYDVDRPILFDGAKSVFEFDGADEAHPAFAADLAEVAVGENLVRGADLAVLVARHGVDLADEAWSGRWYVTLPKFFSDGTLYDAMRVALSLGEEPGGTLSVDVEPDDAWAAELKSVEDPALRAHVSFFCAKGTNGMTFFPDYTTDGLLTEDGGEVIGYWEEAQCQVEVTVVRLSGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T352</accession>
    <name>A0A7W7T352_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylation response protein AidB-like acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="1">
        <location>
            <begin position="230"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36297" checksum="71B683A0979ED6FD" modified="2021-06-02" version="1">MGELFETIRTGAAEADRVGRLPDTVVNALVEAGVTRRLAPARFGGGQLDLPAWVAEIEALSAADGSAGWTAMTTSATSALAWYLPEETADEVFSPPDAVVAGTAAPRGTLTGDRVTGRWGWGSAVDWCTWVVGGISTPEGPRLALFPRADVIVHETWDVAGLRGTASHEWEVVDAFVPADRRVWPPSLHVEAPLPSFPFFSFLAMGVASVCLGIAGRALDEVESTDGLLDLATADARLAAARAFLRAEVDERWASALTGGESTLRQRARLRLACSHAAHEAVSVTRSAFEVAGGSAVFSSSPLQRCLRDVHVAAQHAMVSRRLFETYARVRLDLPVDTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G5</accession>
    <name>A0A7W7T3G5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylenetetrahydromethanopterin reductase</fullName>
            <ecNumber evidence="2">1.5.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.98.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018537">
        <property type="term" value="F:coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="35361" checksum="96DCFC3A952D7E92" modified="2021-06-02" version="1">MVEIAVNLNARSVRDMVDRAVRVADAGAARLGVWDSPVAVPECWTTLGVLAGRTTLPLGVTVTNPVTRHPVVTAAALATLAEIAAGGVFLGIGTGDSGVYNLGRRASTLADLRAYVRCVRDLLRTGRHGDLALDRVPDRPVPIIVSAHGLAALETAAEIGDAVIVGLGFSADVVAAVTEVVHRVADRTGRDPVPLWWNTGSFSVDDDPDRARAAGGWLLAAHAHHFARSGLATKAVPVEYRDPIAALGASYDLSAHGRQPEDAKRRYVDTAIGLGVWDYLCDRFLVAGTPAQVHDRIEALGERGVTRLETSTSVRGVDDLVPILNLFQSTLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M5</accession>
    <name>A0A7W7T3M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="482" mass="51519" checksum="A576A372F394FC90" modified="2021-06-02" version="1">MSGSVVAFHSLGGSVREPALSWTAGLLCSWGHRVLCVDWSMQPHGLSRYLRPVPGLAELLLDQAGTDAVTPIRAQGRGRLYLIATGLPDGRATAVLRGLDWAARYHDDGWGDLVERHRARWVSDYDFVLVDTPAGTADPVGVCLAQLPDRVVTVVVPETTGPTLELLRLTEDRRDALPYDRARLQVLPVPYLQGLDARALPLFDAWADRRSPRVRADLARSDGGLSLSTDVLTTVAALVAHGFADTRTLARDRRSYVAGARHPHEAGLVLVCSPADAPFAARLALRLVGVDCVVAVVGGRLPAGVVPPDRHVCLVLGADDIGAVRAFGRAFDHLGDLRLFAVLVPGSPDRPVPGATVFRIDDGAAVDALAGRLRDGIRPVVRARSLVDRAAEALDDVLAERLSETDWAAVSGLVVRLRSAAARHDGRAVARVLDELGPPRPVGDLPAPDDLVREVPRLLDRLRSSPVGQEAGDLQGGRVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W8</accession>
    <name>A0A7W7T3W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="326"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="572" mass="61457" checksum="9A0E990F50A23359" modified="2021-06-02" version="1">MSLLVVDGLDVSFPGVRAVRDVSFTLDAGQCLAIVGESGSGKSVTARSLVGLAGDTATVGARALTFDGRDLTGLRESGWRRVRGREIGLVLQDALVSLDPLRTVGAEIGEALRVHGVVDRSARPERVRSLLADVGVPEPERRARQHPHQLSGGLRQRALIASALAARPRLLIADEPTTALDVTVQAQVLDLLRGLKDEGTALLLISHDLSVVAGIADRVAVMYGGVVVEHGPADEVLPDPRHPYTQALIAAVPGTRPRGSRLSAVPFEGPEATAVGCPYASRCVRADDRCRTSLPDLSVRCWHPAPAVTTTVSSDVVAPVIGEPLLEAVGISKRFRAPDRTWYDAVKDVSFTLHRGETLGLVGESGSGKTTAARIALGLVAPDAGEVRFQDQAWSSLSERARRPRRRAIQTVHQDPLGSFDPRYTVERLIAEALPRDGRARVAELLDQVGLPKSLLRRRPRELSGGQRQRVSIARALATGPDVLVCDEPVSALDVSIQAQILDLLRDLRHETGTAMLFISHDLAVVRHVSDRVAVMKDGAIVESGPVDDLFDHPRHPYTRELLAALPTTARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z1</accession>
    <name>A0A7W7T3Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional activator FtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="209"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33491" checksum="78895BBC94587F12" modified="2021-06-02" version="1">MHRVVALVRPVQSTFELGCAAEVFGTRRAGVPHHYEFEVCTENPGPVPTSAGYAMTVTSGLEALESADTVLIPGWKPLDEPLSPAVRQALLDGHARGARLVTICTGVFALARTGLLDGRSATTHWQVADRLQEEFPAVRVEPDVLYVDHGDVATSAGAGAGIDLCLHLVRQDHGAAHAALVARHMVMPPHRDGGQAQYAPTPPPDDDLDGLLDWAAARLATPLSVTDLATHLKVSSRTLARRFADRLGTSPGEWLLSRRIAEARTLLEGTDLPVDAIAVRVGLTSAVNLRRRFHDRVGTTPGAYRRAFRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T433</accession>
    <name>A0A7W7T433_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="21185" checksum="C08E9CFF665DA9E1" modified="2021-06-02" version="1">MSSFPSAARKVRDDSLAPKVRSWALRECVLRFAPYGFLATWHHLVVNAAVPARPEDDPAALVRALDELEEAREVWQRVTRAYRTRRRAEKSVGRRTPLPVDRWRNSTLLAFCPDFTTHPTERLVVVVVRVLAGHESRPVHSDSCRACGAPTFDLVCPACGVADTDPSTRRPREPAHVARRWREVWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W0</accession>
    <name>A0A7W7T4W0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-mycaminosyltylonolide 6-deoxyallosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.317</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis; vancomycin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.317" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00162"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033072">
        <property type="term" value="P:vancomycin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="3">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="42925" checksum="526870E1A58B99AF" modified="2021-06-02" version="1">MGPASAAVSRIGLAAIGSRGDVEPLLVLGAALHDRGHDVLFASSENMRDAAEKAGLRFHPITPATPDDVLADPEFRALLRRTTSPGRIARAMPRPTVEQRRSTLAELVAATADLDVVVHTPHTRAAVWAGPAPARWCTAALWPVTPTKSAPAFGFPALGPFNRTTYRLVAAGEWRFFREAVAAVRADAGLPPLSRPPGPPVGHHVLHPFSRAVFPVPGDWPDTVHVTGHWFGPGTGPDPDLAAFVAGGTPPVVATFGSTWVVDPDRALEAALAATRRARRRLVVVGGPETSLPDEVLRVTDADFGWLFPRAAAVVHHGGQGTTAAALRAGVPQVVVPGFADQPYWSRRIAGLGVAAAPIPLPELTADRLGTAVAQVVSDPGFRTRAEALAGAVRAEPGVEAACRVVEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B2</accession>
    <name>A0A7W7T5B2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="48805" checksum="BB068783709333F5" modified="2021-06-02" version="1">MGFTQESLAEAVGVEFSTVGRWERGVLTPQPWRRPRLARVLKVSLEELDDLLDPDVAGVPVSNSLQVAEHQTAPGKPDNGRFGQSGTAPVPGNELQEADVGKSPSPVKSSEPNRRIFLKTSGITAIGATLSTPPAVLQALEIVTSQDADTLDIAADCLEELVCHYSEKLPVAPPSEVYGDLLAVRKFADSLLVRSDSSTRRRADVIASTGWISNLLAVATSYMGNHGSSLVWCLDAERHGHNSGNRDIAAWATFTRATMAYYQGRTNSSAELSGTGQRIASPGTVVFAKLASHEMRSVAMVGDVRRMQEAKKRATAAIEGLQASTTRSGVFSIALSEDPPYTATSLLLLQRFEEAALATERVIETAYGADAGDHGGLSSNHSRTLLILGLARAGIGDVDGAVAAGRQALDGSVVWPTLVLARKLDQALMRTHRSLPEVVEYHELCRSLADSVTVGGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V5</accession>
    <name>A0A7W7T5V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetyltransferase-like isoleucine patch superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="19443" checksum="963654D3DB23E619" modified="2021-06-02" version="1">MSGVFVHPKGLCESDEVGEGTRVWAFAHVLPGARIGRDCNICDGAFVENKAVLGDRVTVKNGTLVFDGVTCEDEVFLGPNVLFTNDLRPRAAIKRTGDALLTTTVRRGATLGAGTVVVCGIEIGEHAFAAAGSVVTKDVAAHSFVAGNPARHKGWVCACGQRLDAELTCPDCGNGYVEGDKGLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T606</accession>
    <name>A0A7W7T606_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 20">Methionine synthase</fullName>
            <ecNumber evidence="6 20">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 20">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">F4559_004580</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 20 23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 20 22">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 20">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="20">Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6 20"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:methionine synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:zinc ion binding"/>
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    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="methionine_synthase_B12_BD"/>
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        <property type="entry name" value="Cobalamin-bd"/>
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        <property type="entry name" value="Cobalamin-bd_sf"/>
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        <property type="entry name" value="Dihydropteroate_synth-like"/>
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        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10 20 22" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="17 20 21" id="KW-0170">Cobalt</keyword>
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    <keyword evidence="16 20" id="KW-0486">Methionine biosynthesis</keyword>
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    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 20 22" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 20 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="15 20 21" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="25">
        <location>
            <begin position="4"/>
            <end position="313"/>
        </location>
    </feature>
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            <begin position="344"/>
            <end position="605"/>
        </location>
    </feature>
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        <location>
            <begin position="635"/>
            <end position="729"/>
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            <begin position="732"/>
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            <begin position="880"/>
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            <begin position="742"/>
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            <end position="1158"/>
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        <location>
            <position position="235"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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        <location>
            <position position="298"/>
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        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="21 23">
        <location>
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        <ligand>
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        </ligand>
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        <location>
            <position position="679"/>
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        <ligand>
            <name>methylcob(III)alamin</name>
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    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="745"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
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        <location>
            <position position="790"/>
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        <location>
            <position position="846"/>
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        <location>
            <position position="929"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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        <location>
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    <sequence length="1195" mass="128939" checksum="0ADB82E3113E608C" modified="2021-06-02" version="1">MGRIENLKRLLDERLVVLDGAWGTMLQAAGLTPADYRPDFLKDHPHDVTGDPDLLNITRPDVILDTHRRYLAAGADITSTNTFTATGIAQADYGLEHLVYDMNLNGARLARQAADEVGGYVAGSVGPLNVALSLSPKVDDPSYRAKTYDQVKATYAEQIAALAEGGVDLLLIETIFDTLNAKAAIAAAHEVAPHLPLWISVTVVDLSGRTLSGQTVGAFFESIAHADPLVVGVNCSLGAEEIRPHITELARLAGTYTACHPNAGLPNAFGGYDQQPEETAALLRGFADDGIVNVVGGCCGTGPDHIAAIARAAADAPRREPVRRAEATRFSGLETFEIGADTGFVMIGERTNVTGSAKFRRLIEAGDHQAAVDVALDQVRGGANLLDVNMDADLLDSEAAMTSFLNLIATEPEVARIPVMVDSSRWSVLEAGLKCLQGKGVVNSISLKEGEEQFLAQARTIREYGAGVVVMAFDEKGQADTTRRKVDICARAYDLLTGTVGFPAHDIVFDPNVLAVATGIAEHNGYAKAFLDAIPLIKQRCPGARISGGISNLSFSFRGNDVVREAMHSAFLFHAVGLGLDMGIVNAGQLAVYEDIPPELLEHVEDVLFDRREDATDRLVTLAETVSGKGKKREIDLTWREAAVGKRLEHALVHGIVDYIEADTEEALHASARPLDVIEGPLMDGMKVVGDLFGSGRMFLPQVVKSARVMKRAVAFLEPYMDAESQGQARRNGKVVLATVKGDVHDIGKNIVGVVLGCNNYEVIDLGVMVPASVILDTALAEGADAVGLSGLITPSLDEMVGVAAEMQRRGMNLPLLIGGATTSKQHTAVRIAPAYESTTVHVLDASRVVGVVSDLLDADRAVTLAAATRADQQRLRAEHETRLRTPLLTLAKARANPEKVSFAEVPVPAFTGLRTLTPDLATLREFIDWQFFFLAWELKGKYPAILDNPVARELHDDAIRMLDKIIADGSMHAIGAYGFWPAHAEGDDIVLDGPDLPSFPMLRQQTAKPDSRANRCLADYISPDGGDHLGGFAVAVHGAEDLAAAYERDHDDYRAIMVKALADRLAEAFAEYLHLQVRRDWFEPDADPDLADLHAERFRGIRPALGYPASPDHSQKRELFTLLEAEKLGLALTDSFAMTPAAAVSGLIFAHPESRYFTVGRIGRDQVEDYARRRGATVAEIERWLRPNLAYDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T626</accession>
    <name>A0A7W7T626_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase subunit 5 (Subunit L)/multisubunit Na+/H+ antiporter MnhA subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030711196" evidence="2">
        <location>
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            <end position="388"/>
        </location>
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            <begin position="35"/>
            <end position="59"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="203"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="292"/>
            <end position="313"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="388" mass="38612" checksum="EB566F9E201B7741" modified="2021-06-02" version="1">MIALAPIAVVLALLGAAAAAGTQADARAARRKAVYWTSGAAALAIAELFTSTVDIPVALVHTRHEALLCAAIALSGVLVAAMAPVSTHPPGVLARALLLVAVSCAFTVVRSEVVDLVLLAVSAWLAWSGLRGRPGGAGRLFALHQVPSLVLVAVGVATGVDVFVVLGLAIRAAAVPAHAWFPRFVGTAPMGLVVAFGTVPLGLVVPESAVATVIGVVTALCGAVFAVVQTDGRRSLAFLLVCGNGIVLAGGGWAAAVLAGSGLAMTVGALAARRDALSFGTPVGDLSRTPRLAVAYLGFGLALAGFPLLAGFATAHHLLDHAAPAAVACLLVAVAVAGIAVVRGFLALFTGTSAETGERDLTPLENYAVAVTLALLVFGGLLPGVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T685</accession>
    <name>A0A7W7T685_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="45295" checksum="D1D96AFA785D2D1B" modified="2021-06-02" version="1">MSAADASPIALDEDFVQRRHTFHQRLREDGGGAVRRAVLPGGLPVWLVVGYDEAKEALAHPALSKDSRRAAPLHDKQEEQGVQVTRLARILQSHMLNQDPPDHTRLRRLVTAEFTQRRVELLRPWVEQVVDGLLDGFADRDRVDLLGDFAFPLTVTVIGELFGVPEDERAEFRVISDGIAFGATPAEMGAASARMADYLADLVARKRAGTDEDLLAALVRARDDEDRLDEDELVAMAFLMLTAGYESTAHLIGNGVLTLLTHADQLDRLRRDPALLPDAVEEVLRFEGPGTTTTLRFAAEPVRLGDVDIAAGEFVLVLVGPVNRDAERFADSDRFDVGRADNRHLAFGHGVHRCLGAPLARLEGQVALGRLVDRFPHLALAVAPEELRWKDSVLFHGLTELPVVPKSLEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D5</accession>
    <name>A0A7W7T6D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="34290" checksum="09F65939FA5CD733" modified="2021-06-02" version="1">MSPLPRRRLGTTDLDVSALSLGSWHTYDRMDFADAVTMIRTAVDAGVNLFDVGVYSVPPMPPVFTDVIWNSIMRASGIPRDEYLVSAKLWLEGFGENGFRPQLENAFLRGGFDVADLVILGDIRTEGVVLEDFVEDLGALTKAGLIRAWGVNNWSATNIRRLREIAAERGLPGPVIAQLKYSIGRRSIPDGEPFGALFADGFAMQASDVLEGGILAGSTGQSREIGRDPGGVREAMREQVAGIAEVAEQLGTSPARLAVAFTLTHPANVTTLFGATKLTQLEDNLAAAELVERVGAEELRALVEPFWVDRGIVDPEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T733</accession>
    <name>A0A7W7T733_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="12"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="32567" checksum="066829D25B8B5C8D" modified="2021-06-02" version="1">MNVFSERVIALLAPGQGSQTPGMLAPWLELEGAEKRVAQWSESTGLDLRRLGTEADADEIKDTSVTQPLVVALAVLAAEELRRRVDLPADTVVAGHSVGELAAAAVAGVLTADDAVALAAVRGAEMAAACSLAPTGMAAVLGGEEDVVLARLDELGLVGANRNGAGQIVAAGPLDAIDLLVETPPERAKIRRLQVAGAFHTGYMSTAEDAVRTRAADVAVSDPVFPLLSNADGAVVDSGDEVLRRLISQVTRPVRWDSCQSTLAGRGVTAVVELPPAGALTGLAKRELKGTPTLALKTPDQLDQVVALLTAEVSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T738</accession>
    <name>A0A7W7T738_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13502" checksum="63B99A13C0FD2285" modified="2021-06-02" version="1">MIRAAGSRWSWCFPAVVESLERDRDVRHLYLTAVAARVLGVPWERAGRIAGDVEHGRFELGAERVGRFTAELANADDGAALWCGVRFLGSETSARGALQRTLRHEPSRAVRRAVGDVLVRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T790</accession>
    <name>A0A7W7T790_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="26413" checksum="BAFEBBE2D1EBCD58" modified="2021-06-02" version="1">MTRRRAVVTGASSGIGRATAVVLAREGFDVAIGYRVDADAAGRTAAEVGDAGGRAVTFTLDHTDPGGAASAVDRAADELGGVDVFVNNAGVNRRAAFLDETLDGWTRLLAVDLTGPFACAQAMARRLVAQGTGGRIVNVTSVHERIPIDGGSAYCAAKGGLLMLTRVMALELAPYGITVNAVAPGETATPMNGVPEHLDAGEIDRPMIPVGRPGRAAEVAALVGHLASEAAAYITGSTLHIDGGLALMGAIPNQAYAGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7L0</accession>
    <name>A0A7W7T7L0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF402 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007295">
        <property type="entry name" value="DUF402"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04167">
        <property type="entry name" value="DUF402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF402" evidence="1">
        <location>
            <begin position="70"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22945" checksum="6D2E0D760E6106E6" modified="2021-06-02" version="1">MGFFAPGDVALRREVLHGKPWLVTPTRVIVDEPDLLVVFVVPGTHFGFPTHHRPHPWQVKGSTHWRGNGKLQLHRPGDAYSVDLFWGGEERRFEGWYLNLQDPFRRTPFGFDTLDHELDYWVLPDGAWEDKDRVEFEAQVVDGKYTAEQGAEIRAVGVAIEEMLNARTQWWAPEWAEFEPDPSWPVPVLPAGWQDLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7R9</accession>
    <name>A0A7W7T7R9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="1">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="1">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtnB</name>
        <name evidence="3" type="ORF">F4559_005502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01677">
        <property type="entry name" value="Salvage_MtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="PTHR10640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="2">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21093" checksum="0BC562A0259D4CA6" modified="2021-06-02" version="1">MTPGAALAAECARYTAMGWMRGTSGNLSVVLSRDPLRLAVTISGKDKGELGPADVVEIDAEGRTDDPVRVPSAEAGLHGRIAAVTGAGAVVHVHALAPVVAAEHWPGGVELRDLEMLKGFGRAAHDDVVVIPVVPNSQDMKVLGDAFEEGHRADVPALIVARHGVYVWGDDLHHARHRLECLEWLLRFKVETRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T815</accession>
    <name>A0A7W7T815_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="202"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="467" mass="49465" checksum="C299A4E5CF4BFBD7" modified="2021-06-02" version="1">MTGDPENPEREAVAAFLDDTVARLRDWLAIPSVGVDPAHRADMDASARLLADTLRADGWPDVRVWDEGPALPAVYACLPAADPDAPTVLVYAHHDVQPAGPLDRWDHPPFAGTLVGDELFGRGASDDKGQVAMHLLGVRAHLAAIGARQPAVTIKLLVEGEEETGSPNLGRLVDDHAADLAADLVVFSDTPVYAREAPTVCTGQRGVYAAEVTFVGGQSDVHSGRAGGSVPNPVTGLARLVAALHDDRGRVRIEGFYDDVVEPTAAERADYAALPFDDDTWLANSGGARGLAGEEGWSTLERVWVRPTAEVNGFHGGYTGAGVMTIVPARASVKLSFRLVPDQRPEHVAEALRRFVAAHTPAGLHAEVVDVGDGVPPYAVDVAHPAVKALHEAMETAFDQPVRFSRTGGSGPAAVLRARLGVPVVYLGATLPDDRIHAPNERVVVSQLGRGAEAAAHLWRLLAERLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T840</accession>
    <name>A0A7W7T840_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Superfamily II DNA/RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_005662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="122"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="321"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="606" mass="64758" checksum="9DD3DB6EFCF3A71D" modified="2021-06-02" version="1">MPPGEGARTLLAGPSRATARPAPGRAADDAVERPVQAVRARCTREAITLTATNEDTDHLDPVALEHSELGVPDVDTSHPLTANAPVQTDSPTFAELGVRAEIVRALGEAGIERAFAIQELTLPLALAGDDVIGQARTGTGKTLGFGVPLLQRIITPGDGTPQALVVVPTRELCLQVTHDLTDASRHLDVRVLAIYGGRPYEPQIAALRKGVDVVVGTPGRLLDLAEQRHLVLGKVRGLVLDEADEMLDLGFLPDIERILRMVPDERQTMLFSATMPGPIITLARTFLNQPTHVRAEENDAGAVHERTEQFVYRAHALDKTELLARVLQARERGLSMIFTRTKRTAQKVADELVERGFAAAAVHGDLGQGAREQALRAFRAGKVDVLVATDVAARGIDVEGVTHVVNYQCPEDEKTYVHRIGRTGRAGRTGVAVTLVDWDDTPRWKSISDALGLDRPEPVETYSTSDHLFAELGIPAGSTGRLPLGLRTRAGLDAEPEEKIKGAKRSRRRRGGGSDESAPAGEAVKRPAKAEGDESSAGRTRRRRRTRGGAAGNDTAENTAENTTGAVAVEAGSGDAAPSAEGRTRRRRRRRSGTESGGAPAEGSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A2</accession>
    <name>A0A7W7T8A2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliP</name>
        <name evidence="14" type="ORF">F4559_005735</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031080649" description="Flagellar biosynthetic protein FliP" evidence="13">
        <location>
            <begin position="39"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="28467" checksum="3F7F9B329686BC7B" modified="2021-06-02" version="1">MIGRRFVALLLTFFTVGAVVFGGTATASASASVQPAAAVSGAVAAAPVGPTEPTSPDVTVTVGTPDKPSESLVILITLTVLSVAPALLLLCTSFTKIFVVLSITRNALGLTNVPPNQVLAGLALFLSLFIMGPVASKVNSEGVQPYLNGEKSQSQAFEDGSKPLREFMLKQTRPEEIALFTKVSGADKPANADAVPMTTLVPAFALSELRAAMLIGFVLFIPFLVIDMVVSAGLMSLGMMMLPPVTVALPFKLLLFVLANGWGLLVTALVGTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C5</accession>
    <name>A0A7W7T8C5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="26938" checksum="F57D47EE17C99BDD" modified="2021-06-02" version="1">MPAITDRDVVRALRPFVRATGPLLDTLRDVDLLGLRDRTVEEGADRTRLERVWDRLARVTVPGTRAWAEADVTARDDFWLDRVGHVVSLIAALPGIGGALADRLPLQSTLGTAGQGLLLSALAGEHGFTSTEDRVRLLAHVLFHRDVDPTPVEADEDRRTEDLTADLKGRSTIKGIGRTLWKLARVLWALEGELDKRPRGRFYHQALGMLPVVGVVGDYFGERSALKRVRSAAYAWFAAESATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G0</accession>
    <name>A0A7W7T8G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="185"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="407" mass="45924" checksum="78C2C198A29245E9" modified="2021-06-02" version="1">MGHIQDRWWKEVTDPVSGQVTRVKTSSYGKGLRYKVRYLDPQDNEKSKSFPDRQKKRADDFLLEVESDKREGKYVDPRAGEILFSKYVVTWFGGQSQDAATQENLHNQVDKRIEPFFGRMKMSGITIPRVREWIGWLGDAGLSLRYQQLLFDRLSSILNAAVEEKIITSNPCKARSVQRPSPPERRVTPWPEARMRSVRLALPIEYRIALVLGGGTGLRQGEVFGLAVDDIDRDALQLNVVRQVRIVGNQLVYALPKSKKARTVPLGGGVLDALDDHMADFPPVDVTLPWERPGGEMVTARLVLSMGGTACRRQVFNMGVWRPAFATAGLEYRPREDGMHGLRHLYASSQLENGVSIKALSLNLGHHDPGFTLRTYTHLMPTSHDRSRRAADRLFKPRGRPDGLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8H3</accession>
    <name>A0A7W7T8H3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteic killer suppression protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10903" checksum="61E1A3C408AE5067" modified="2021-06-02" version="1">MLRSFVGRETERVWLRRRSRALDPAVQRVALRKLAILDAAETLEDLRVPPGNRLEKLQGDRAGQYSIRVDQQWRICFRWTDAGPEDVEIADYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M6</accession>
    <name>A0A7W7T8M6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="14" type="ORF">F4559_005961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="474"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="876" mass="97107" checksum="25723B6BC9772D89" modified="2021-06-02" version="1">MDMSKLTRKSQEALQEAQSVAQRHGHTETDGEHLLLALLDPADGLAPRLLARTGADVDGLREATEAELARRPKVTGPGATPGQVYVTRRLAGLLDAAEREAKRLKDEYVSVEHLVRALADEGAKSAAGRLLTQYGVTRESFLTALTKIRGNQRVTSATPEGAYEALEKYGRDLVADARSGKLDPVIGRDAEIRRVIQILSRKTKNNPVLIGDPGVGKTAIVEGLAQRVVRGDVPEGLRDKTIFSLDIGALVAGAKYRGEFEERLKAVLAEVKAEEGRILLFVDELHTVVGAGATEGAMDAGNMLKPMLARGELHMIGATTLDEYRKHIEKDAALERRFQPIVVDEPSVEDTISILRGLRERLEVFHGVKIQDGALVAAATLSHRYITDRFLPDKAIDLVDEACARLRTEIDSMPAELDELTRRVTRLEIEQAALSRESDQAGKARPADLDRELADLRAEADSKKAQWEAERQGIRRVQELRSELELLRHEAEEAERDYDLNRAAELRYGEITEAERRLAAEEERLADKQGRKRLLHEVVTEDEIAEIVASWTGVPVSRLREGEREKLLRLDEILHERVIGQDEAVRLVADAVIRARSGIRDPRKPIGSFLFLGPTGVGKTELAKTLAAALFDSEENTVRLDMSEYQERHTVSRLLGAPPGYVGYDEGGQLTEAVRRKPYSVVLFDEIEKAHPDVFNTLLQVLDDGRITDAQGRTVDFRNTVIIMTSNIGSQHLLDGVTSTGEIKPYARDAVLAELRHHFRPEFLNRVDDIVLFTPLGPGEIERIVDLRFDELRHRLAELGIAVELTGQARKLIARHGFDPVYGARPLRRYISHEVETKIGRTLLRGEPTEGLVITVDAKDGELVVTYSGGEGRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N7</accession>
    <name>A0A7W7T8N7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-specific alpha-keto acid dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23530" checksum="6FA77C330FDD897F" modified="2021-06-02" version="1">MADYVLMSMLMVVRGAKATIRRVDSHDYRLGEVRGKELRDLTVGVVGTGRIGTAVVSRLRGFGCRILAHDTRPGVAVDHVPLDDLLRQSDIVTLHTPLNADTYHLLDRRRIARMKRGAYVVNTGRGALLDTGALVAALESGALGGAALDVLEGEEGIFYADRRDEPVENGHLARLRDLPNVFVSPHTAFYTDHALSDTVENCLVNCTNFVRGNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P5</accession>
    <name>A0A7W7T8P5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="18" type="ORF">F4559_005919</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="17">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="265"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="399"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="448"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBB4968560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="492" mass="50920" checksum="B5F28C47197C5BF0" modified="2021-06-02" version="1">MLEGVPTPVSTIVLAAGEGTRMRSATPKVLHRVAGRSLVEHAVRAAAGTDPDHLAVVVGHGRVAVAEHLDSLATALDRKVTVAVQEEQNGTGHAVGCGLAELPVDLTGTVVVTYGDVPLLDAQTLRALLLEHGERGNAVTVLTAVVTDPTGYGRIVRDADGAVARIVEQKDASPVEQAITEINSGVYAFDAVVLRDGLSRLSTDNAQGELYLTDVLRIARDDGRPVGTLVTGDAWLVEGVNDRVQLSRIGAELNRRIVERWQREGVTVVDPATTWIDADVTLERDVLIEPGVQLKAGTTVGAGAVVGPDTTLSGCVIGADAFVVRTHGSGAEIGAGASVGPFAFLRPGTRLGDKGKVGTFVEIKNSTIGTGSKVPHLSYIGDATIGEHSNIGAASVTVNYDGVHKHPTVIGSYARTGADNMFVAPVTVGDGAYTGAGTVVRRDVPPGALAVSGGPQRNLAGWVTTRRPGTGSAEAAQRAQASEQADQTEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P6</accession>
    <name>A0A7W7T8P6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor synthesis domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="16619" checksum="68BC460488B4685E" modified="2021-06-02" version="1">MERSAQRLGRALVVIVDDRVAHGEHDDSTGPLVTELLEEAGFIVDGTVAVEGEVVGIRAALNTAVIGGVDLVVTVGGTGVSPRDVTPDATQGVLDRPIAGIAEALRASGLAAGAVDAGISRGLVGVSGSTLVVNLAGSRSAVRDGMATLTALVPYVIEQLSGLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z8</accession>
    <name>A0A7W7T8Z8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">o-succinylbenzoate synthase</fullName>
            <shortName evidence="4">OSB synthase</shortName>
            <shortName evidence="4">OSBS</shortName>
            <ecNumber evidence="4">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menC</name>
        <name evidence="6" type="ORF">F4559_006128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043748">
        <property type="term" value="F:O-succinylbenzoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00470">
        <property type="entry name" value="MenC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010196">
        <property type="entry name" value="OSB_synthase_MenC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041338">
        <property type="entry name" value="OSBS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18374">
        <property type="entry name" value="Enolase_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="5">
        <location>
            <begin position="73"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33177" checksum="C748526E667052BA" modified="2021-06-02" version="1">MFVYSIPLRNRFRGITVREGVLFEGPAGWGEFCAFLDYSDSECVPWLDCAEESSVESWPSPVRTRIPVNCTVPVVDPERAREIVLKSGCTTAKVKVADPGVDLAADLERVEAVRDALGPQGKLRVDANTAWDVDTAVHAIRELDKVAHGLEYVEQPCPSIEELAAVRRKVDVRIAADESIRRADDPLKVAVAGAADLAVIKVAPLGGVRRALRVAEACGLPCVVSSAVETSVGLAAGLALAGALPELDFACGLGTLSLLDGDVVAEPLTPRDGWLPVPTSPPVPVLRDEFAADAETTAKWLARVDRVRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T910</accession>
    <name>A0A7W7T910_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">F4559_006143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="540" mass="56598" checksum="D0CFF97858AB0970" modified="2021-06-02" version="1">MAKMIAFDEDARRGLERGMNTLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPWEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPLGLKRGIEQAVEAVTEQLLKTAKEVETKEQIAATASISAGDSTIGELIAEAMDKVGKEGVITVEESNALGLELELTEGMRFDKGYISGYFVTDPERQEAVLEDPYILLYGSKISSVKDLLPLLEKVMQGGKPLLIISEDVEGEALATLVVNKIRGTFKSVAVKAPGFGDRRKAILQDIAILTGGQVITEDVGLKLENADLSLLGKARKVVVTKDETTVVEGAGDAEQIQGRVNQIRAEIEKSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALLQAAEAAFAGLKLEGDEATGANIVKVAVEAPLKQIAINAGLEGGVVVEKVKGLPVGHGLNAATGVYEDLLAAGVPDPTKVTRSALQNAASIAALFLTTEAVVADKPEKNAAGPAVPDAGGMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G6</accession>
    <name>A0A7W7T9G6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25896" checksum="4CB55E9D462CEA9A" modified="2021-06-02" version="1">MRPRVLVVDDEVGVRRALERGLSAEGMEVVTAADGPNALRVALTGAFDVVLLDIMLPGLSGYRVLQRMRAEGVRTPVLMVSAKDGEVDQADGLDLGADGYLVKPFSFVVLVAQVRALLRRNTADSGRRRLKLGELVVDRATREVSWAGEQLSLSPREYAVLDVLAGRAGSVVTKDELLRAVWGDEQAATRNAVEVYVGYLRRKLDAMGAGEVVRTVRGHGYLASTPDLDAALGAASSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I1</accession>
    <name>A0A7W7T9I1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23523" checksum="257E202AB8EBC82A" modified="2021-06-02" version="1">MPVEHLRGAGYSARVLKAVLMPMLGVPAREWSIRELADPAGFSYSPVRVACGDLYSLGHLRYRLQPGSRDFCRAAKLYRLTDAGTVEWGGRLARTGSLLTPTTPLSDLTAQVMGARLPEVRRARTDLVGYSKGTLILVMRAVLRRPARMWTSDQLSLATTISTCTVLLACHDLVAAGHLDNLPLALRRDGTPTKCRFRLTSNGADAWGEVFELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R0</accession>
    <name>A0A7W7T9R0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17830" checksum="D783DFC37416FFBE" modified="2021-06-02" version="1">MFVRAIEEADRIVVGRLVLELWGAHTAVAHGQVFFPASLPGFLVEQQEQVVGLLTYTASDGQLEIVTIDALRRGRGVGSALVDAAVHRARQIGCSRVRLTTTNDNLDALRFYQRRGFRLAALRPDAVRESRRLKPEIPSVGEYGIPITDELDLERWVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA15</accession>
    <name>A0A7W7TA15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="22390" checksum="6F9B1101E51633AE" modified="2021-06-02" version="1">MTAAASSDADLIAAHAAGDPHAFSELVKRHRDRMWAVALRTLRDPEEAADALQEAFISAFRAAAGFRAESQVTTWLHRIVVNACLDRMRRRQTRPTVPLPEAGPGEPVAPRDAMAERETRLVVQAALNELPEEQRAPIVLVDVEGYSVAETAQLLGIAEGTVKSRCARGRAKLAKVLGHLRNQSASANVPVHDVQVQQGRQLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF3</accession>
    <name>A0A7W7TAF3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YgaE (UPF0421/DUF939 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="37479" checksum="F006D07A71FC19F1" modified="2021-06-02" version="1">MRDEVTRRIDRWRGTALPIVHTALAAGLSWWAAMAVAGHEHPFFAPIAAVVCLGVSLGQRLRRVVELVVGVSVGVGVGDVLISWIGTGPWQIALVVALAMSAATLLDGGAVIALQAGSSAVLVATLLPPSTGGGLDRMVDALVGGLVGLAVTALLPAHPLRVAHRHGRVVLGELATALRGVADAVAERDAVRAASVLARLRESQSAFDEFTTALRTGGEITSLAPLRRPARHALDRYASAAAPIDYAVRNTRVLARRALAALRDDEEIPEVLIEVLRGYADAVDLLRGELARGTEPVTARKAIRDAVRSATAHRLGGDTLSVKVVLAQVRSVAVDLLQATGLTRAEAAEALPPLSRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAQ2</accession>
    <name>A0A7W7TAQ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucyl aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="299"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="452" mass="46592" checksum="C38ECB30A1E3E9DA" modified="2021-06-02" version="1">MRQPLPTPLPSVDVAGSPRRGVLRVVVASAGEDDGDIGAPARRDPWVLGVGAGTAGDWRTAGAVLSRALTDVAERCDVELPADADAAAFTLGLALGGYGFKVTGQERPRRVRSVRLVTGAPVADAVREALDAAAATALARDLANTPSNTKDPAWLAATTAKLAGAVPGLDVRVRDEKWLRAEGFGGVLAVGGGSPRPPRLVELAWRGTGGGPHLVFVGKGITFDTGGISIKPAEGMHLMRTDMAGGAAVIAATIAAARRRLPVRVTALVPCAENHVSGSAYRPGDVIRHHGGTTTEVTNTDAEGRLVLADALAYAVRTLSPDLIVDVATLTGAMKISLGVRTAGLFATDDALAADLLAAGEAAAERYWRMPLLQEHADAVHSDLADLRQCPPGPGGIMAALFLREFAADVPWAHLDIAGPARSDKSYAEVTPGATGFAARTLLALATAKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBA2</accession>
    <name>A0A7W7TBA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase YjhB (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="17607" checksum="46429C08F2AA9C8B" modified="2021-06-02" version="1">MSRIDYLNDPNAPKPNSIRVAVSAIVQDPTDRLLMIRRTDNDLYSIPGGAQDVGEPIGRTVVREIKEETGYDVEPTDVIGIYSDPAHVIAYTDGEVRQEFSICFRARLTGGELRTSSESSEVRWVARDDLAALTIHPSIRLRIQHGFDNRTTPYFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBB6</accession>
    <name>A0A7W7TBB6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="27010" checksum="BB5C14014ED6785E" modified="2021-06-02" version="1">MTPPTALITGATAGIGAAFARRLAAEGHDLVLVARDVARLEENAAALRAKHGVHVTVLPADLSTSEGRGAVEAHLAAETPDLLVNNAGFAHAGEFAKTPVDGLQAQLDVNVTSVLRLTRAVLPGMIARGRGDVVNVSSVASFLPGRGSTYSADKAWVTSFSEGMYQATEGTGVRVLALCPGFVRTEFHARAGIDMTETPEALWLDADDVVHQALADLRAGKPLSIPGAQYKAIVTGAKLMPRALLRYLASRAVGGRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTY4</accession>
    <name>A0A7W7WTY4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031552209" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="30"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="32483" checksum="63E021B0A3650BE7" modified="2021-06-02" version="1">MFRTALALAAVATFATAPTAGASAALEWVALGDSFAAGVISSAGPVLVRDGCERTRGAYPRVLSARLGFLWRLVDVSCGGATVANMVDEPQYPTGRHLPWLGVVDPAYPFPPVWPQVHAVSAATDLVTVSGGAETVGFPELLSACESLGSGHDGDESPCRDLFTSGADGVPTVAERLAYTGVAVDYLLDVVRARAPLAASIVVGYPSIIPVDTGTCLRVGGESYFEFGHTTYADLDWLRTGVLEPLNALLAAKAAAHGALFVDLDLVTRGHDVCASEQWVEGFVSRTGDWAFVRPNLAGHAAAADAILTGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ6</accession>
    <name>A0A7W7WTZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="370" mass="39017" checksum="907A1B7C85E61A98" modified="2021-06-02" version="1">MWKVLTAAVIAVLVIWEPRAALSSLGGAACGVWATLALLQLTLLIGALLFRVRVSLVVIGVGSEVRTWTRPERRVVLRTVPLLVSVGVTSIRTPVRPRLWLCSLLSVLITAAAVAVPWFALTEPFPRGVAIGGTAVLVNALVPRRGAGVTSPGWFLFALPRLTGRPAAELDATPLVTRISDAVHEGHLDEAEKLAGELLAEHPTLLVAIGSRISVLTMRGRYAEALHLVSSLVGRTDLTPRDMAFVMAEMASSTANAMEAGQLPAEIGMGAAHRAIEGAIELGYPRYRACGTLAQLALLTGDHAKALDLGVQAKHTSQSSLGRADALATIARAHMAAGNNAAARETLTEAETLAPWAPRVAETSARLHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU61</accession>
    <name>A0A7W7WU61_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="37" mass="4041" checksum="840B34DB08B39817" modified="2021-06-02" version="1">MDWDAGSGVAVEVLATALKEFLVTGHRPTCVEWQDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU87</accession>
    <name>A0A7W7WU87_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas2</name>
        <name evidence="11" type="ORF">F4559_000841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10716" checksum="E43E20D553D369D4" modified="2021-06-02" version="1">MELLVTYDVDTTTPEGRRRLRQVAKACEGYGHRVQKSVFEIVCSPGQRLRLRAELLEIIDATSDSVRIYQLDRGSFDAAEHLGSAVNVSHGGTWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH4</accession>
    <name>A0A7W7WUH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="137"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26634" checksum="30D5895973026D8F" modified="2021-06-02" version="1">MDAPRRLPVPAELLHWVDGIDLESYRSGPLVHLPDAATTLVWRTLADGAGALFVMGPRTRAAYYDAKDVPVCVRFRFAPGAARVLLGMPVDGFADRVVPFDGLRGTATARPGAVLDRMAAALADRVRAARLRDRATAELVRRASIGLARKDGDFRIGDVARRLGVGERHLRDAFTTTVGIPPKRFVRLARLRAVLSGLRREPRALLAGESGYYDQSHMTAHFREVMRVTPTDFLAGRLPVVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV12</accession>
    <name>A0A7W7WV12_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12346" checksum="4D37150CE1876613" modified="2021-06-02" version="1">MPEPAATLASVRVERPAEDVVVLHVSGELDTTSADELAKPLRTEVVAGLRIAVVDLGGVRFLGSAGLEALVAGSKRAKDLGVRLVLAASNRAVVRPIQATGLDAVFEIVPTVEDALSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV48</accession>
    <name>A0A7W7WV48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superfamily II RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="212"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="827" mass="92161" checksum="E4351950791497DC" modified="2021-06-02" version="1">MTLTDRLPATYDADVLYDTFAEWALERGLELYPAQQEALIEIVSGSNVILSTPTGSGKSMVAIGAHFAALAEGKRTYYTAPIKALVSEKFFALIDTFGADNVGMMTGDASVNETAPIICCTAEILANIALRDGAAADVGQVVMDEFHFYAEPDRGWAWQVPLIELPNAQFLLMSATLGDVSFFEKDLTRRTGRTTTTVRSVQRPVPLNFQYVLTPLHETIEELLHGREAPVYVVHFTQASALERAQSLMSVNVATRAEKDAIAATIGRFRFTSGFGKTLSRLVRHGIGVHHAGMLPKYRRLVEQLAQAGLLKVICGTDTLGVGINVPIRTVVFTALAKYDGQRTRHLKAREFHQIAGRAGRAGYDTVGTVVVQAPDHVVENEKALAKAGDDPKKRRKVVRKKAPEGFVSWSDQTFERLKDAEPEPLTSSFQVSHALLLNVIGRPGNAFAAMRHLLEDNHEDRAAQRRHILRAIQMYRGLLAAGVVERDGDDFRLTVDLQVNFALNQPLSPFALAAVELLDREAPGYALDVLSVVESILDDPRQVLSAQEHKARGEAIGAMKSEGIEYEQRMELLEEVTYPKPLSELLEAAFTTYRRGHPWVSDHHLSPKSVVRDMYERAMTFTEYVSFYQLARSEGLVLRYLADAYKALRQTVPEDAKTEDLNDLQEWLGELVRQVDSSLLDEWEKLRNPGEEETPLDDRPPAVTRNLRAFRVLVRNAMFRRVELAARRNWYELGQLDGDAGWHAEDWQEAMEPYFAEHDSIGTGPDARGPALLLITEEPGLWRVRQVFDDPAEERDWGFTAEVDLAESDETGGAALRVTEVGPFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV67</accession>
    <name>A0A7W7WV67_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dipeptidyl-peptidase-4</fullName>
            <ecNumber evidence="4">3.4.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPPIV_N" evidence="3">
        <location>
            <begin position="106"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="2">
        <location>
            <begin position="485"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="682" mass="73388" checksum="24840B3B365FE064" modified="2021-06-02" version="1">MGNEISFPRQQARTQRFTLGAPRTVVVSPDGGRVYFLRTAGGRANGLWVFADGVETLLVDPDRLLTDPEDLSPEERARRERSREQGAGIVGYATDGDVTRAAFTLSGRLFVVGLATGDVRELPTPGPVIDPRLDPTGRRVGYVTGGALHVVDLDTGEDRVVAEPDAPDVTWGLAEFIAAEEMSRFRGYWFSPDGGRVLAARVDNSPVDRWYIADPANPATPATEIAYPAAGTPNADVTVAIFGPAGRVDVDWDRAAFPYLTTAHWSAGGRPLLSVQSRDQRHVRVLAVDPDTGTTEVVADDTDPHWLEIVPGTPAWTPDGRLVRVLPQGDANRLLVGDRAWTPDGFQVRAVLEVTAEDVLVSASTDDPTRIHVFRVTADAVERLSAEDGVHGAARGGDTLVLSSAGMDHFGTRTTVSGVEIASMAEEPVLTPEVRLLTVGERNLRAALLFPRDHVPGTKLPVLLDPYGGPHAQRVLAARNAYLASQWLADQGFAVLVVDGRGTPGRGPVWEREIASDFAGATLDDQVDALHAVAATEPDLDTTRVGIRGWSYGGYLAALAVLRRPDVFHAGIAGAPVTDWRLYDTHYTERYLGHPAENPEVYDTNSLIADAPNLTRPLMIVHGLADDNVVAAHMLRLSSALLAAGRPHTVLPLSGVTHMTPQEEVAENLLLVQVDFLKKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC9</accession>
    <name>A0A7W7WVC9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="91"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="384" mass="40705" checksum="0F2EBDF218C0E0FC" modified="2021-06-02" version="1">MTVTAPRQVDPAEDAHSEELAFLAAYDDGPRPPGWRLTPRAVVTFVVGSGGDTLALPKGRKAAGAPARLEIKAKFVGERALVERAVVTLAGERGLLLVGEPGTAKSMLSELLAAAVSGSSQLVVQGTAGTTEDQLRYGWNYALLLAEGPSPRALVPSPVLTAMRGGGVVRVEEVTRCLPEVQDALVSILSDRRIAVPELSGTADSTVHAAPGFTVIATANLRDRGVSEMSAALKRRFNFEAVGPIGDLAAETELVRRQATAALARVEAEFSVDAVVLEALVTAFRDLRSGVSQEGWSVERPSTVMSTAEAVAVATSLGLSDAYFPGDRDTLSLLPGHLLGVVRKDDPADAARLLGYWDGPVRRRAESGARTWRRLWELRDVLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF7</accession>
    <name>A0A7W7WVF7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KDO2-lipid IV(A) lauroyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.241</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.241" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="33386" checksum="D8C3CD721352C35D" modified="2021-06-02" version="1">MSERLADWGYAAGWKLVRLLPEGVARAAFDLGADRASRRGGPARLRANLRRVVPQAGERELDELVRASVRSYARYWREAFRLPSTDLAAAARRCDDMISGVENLDAALAQGTGAVVALPHCGNWDMAGVWLVHHSGSFTTVAERLRPESLYRRFIDFRESLGFEVLPLTGGDRNPATVLAERLRQNKVVCLLADRDLTAGGVPVTFFGERTMMPAGPAHLAATTGAALLPVGLWFTDDGWGMRIHPPIRVSDVGAATQSLADVFAADISTHPADWHMFQPLWLTDLPESRQRALARVLARREGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVJ2</accession>
    <name>A0A7W7WVJ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="16064" checksum="FB29EFBAD1EBC959" modified="2021-06-02" version="1">MTHLEAVYHNDRPVSVLRDREDVARFVQELLAADWEHSAATVHAVDPDHRKEFPDHELTIGVDPDTGMGGLRYTNDEGTWYSRGDRTNRGGVVYVYFDTGHDFPADSEVRLHLIHDALDELLGTGGQRPHCVAWQEATDQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM2</accession>
    <name>A0A7W7WVM2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031522677" evidence="1">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="60"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="33620" checksum="153BB834200E4D0A" modified="2021-06-02" version="1">MRRTAALLALLALAGCSTAPAVPAAGPPTSVAVEVQPLKAALKITDPHGVEVSLTKPAERIVCLNGLCDDIVVDLGLTPVGTSNPTLVSHPALLGDKGKDVPVVPGTFGAEDVEYIAGLRPDLVIGLPGVHDSLRPAIEKFAPLWTAEPATWEESVGYLRALGALTGLTDPAVGAEKAFRTKLAASIGKTHADGRSAKKVLLMYGSVDAIGVDTTSSLKGDLLGRLFTYPFPAKGTDVDTASNYSVEELLAQQPDVVFVYSLLFSAEDRTLSAQLADNPVWQQIPAVRANAVHETHAKLWGSGRGLRSLTAVIDEALAKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP8</accession>
    <name>A0A7W7WVP8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family leucine-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14219" checksum="5E21CB78B44FA7C4" modified="2021-06-02" version="1">MSTADLARAINMSASSTADRVRRLTDQGVIQGYRAVVDPAALGYPLTAFIRVRLTTGVANPFRELLQTTPTITEAHHLTGDDCYLLKVLARSMPDLEELTGRLVTFGHLTTNIVFSSPVDGRTLPPAEDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF5</accession>
    <name>A0A7W7WWF5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prolyl aminopeptidase</fullName>
            <ecNumber evidence="2">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25404" checksum="51AC46808CB9C53A" modified="2021-06-02" version="1">MNTTAHLVRDIELLREHLGVGRWMVFGGSWGSTLGLHYAESFPERVSEIVLVAVTSGRYDELEWLYHGLGRLFPEEWSRFRAGAPVGSVDLVAAYDRLLNDPDPVVRERAAADWTDWESSIVSLEPDYDPGPRFADARWRMGFARITAHYFARKAWLADGEVFGRLHRIQGIPGVMVHGRLDLQGPLVTAWELARGWPAAELVVVPGASHSAGDPGMVEAVVAATDGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR9</accession>
    <name>A0A7W7WWR9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025904">
        <property type="entry name" value="Tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13809">
        <property type="entry name" value="Tubulin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115822" checksum="8130599C8E5655FF" modified="2021-06-02" version="1">MRIYQPMMFVGLGGTGCRIGAELERRFREELCGPGGTDLVDVMPGKNFLPYQLPGCLQFVYADLSEDEFGLLERRVVPDLDHRAAAERTLHVVRDLVPQYDTYPEVARSLRLSADEEVVRWLPPQDGEPRIGPLVRGAGQLPTVGRAALFETFRSGLAPAQTPLLRALGNINNSFGELALLGGGHRTPSCDVFVAFSVAGGTGSGLFFDYLHLIGDAFGQSGLRARIYPLVVMPSAFDEGLGGGRPARLNAGRALLDLFRLVDDQNAQAAGTELDHEGVRGTLSVRYPDRAEIHLRASTVQTAFLFGRGPGVRREDLHRSVVSLILSLVGTDVATDAEDARHATQQTFMSFADSFINGAVEREAPARTGIGNRGVSTGSVASMTIPVDDIADLISSRLLAEAVSELDRVPAGAAEDNADLIDRFFIESNLDALRERAPEPISEPAPTQGATAIQRALTTRVRTMESALRAFVPELDGRVGNLTQVFDPLHALRSLLGSVDPFRAQRVVSGEDGQADEASRAGFAGALESRRGEPPAPDGIGVNPPTGLRVSGGWLRKARWADSAVRSAIARQDEWYVWRARRAWSNAWNEQAPRWQYKVEDLVRRITALTGVFRDHAAADRRRFTARTRELYQERVGVTYLLPRQGHLEPFYDAVVRRFVDLNVMRGRLRPTSTVGELVGVLLGPAGWQDAYDTVLTGRDPSVAVTRVRDRLKQEVKVLLRHRDARFPPLLPSLQDLLLAATGRSDNGIGGDELAQFREKLAGLVPGGFAPSGTGRLRILFSYPSGERDPELERYLHREVALPRGADTVVEFRPIAAETIAVVLFRTSMGLTEVPEVRDVLKYWAAALRNEESQDFLRWRQRLGYDFGYLATVPEHRERILHHLLCALWNGQVTVEGDPESPTAIVIRPGARERPSMRLQPLQYGRLSSWAGVLAAYEEWVLTDDEQIRLDLCAALIATTPRGVDHRPDPPASVFDLVWGLAATELRLIDEAIAEGGGDLTRLHDLREFWAETLPAALKLPFRGVNRPLRDNLADLRGWFEHDAGQEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX27</accession>
    <name>A0A7W7WX27_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17115" checksum="D596BA8384796F0D" modified="2021-06-02" version="1">MLFLDVDGPFIPLGGTPVDHGHDNTAHPLLDRLDPALGPALLGLGRDLLWATTWGEDANTLLCPLLGLPRLPVVTWPDGPDDGVDRWFGLHWKTRTLVGHAAGRAFVWVDDEITDADRTWVADNHPGPGLPYRVDPARGLSLEDVDHIADWLRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX77</accession>
    <name>A0A7W7WX77_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10392" checksum="D82C9048E40DD937" modified="2021-06-02" version="1">MPAQLDESCAVGDHDLGAGFVGQSADQAESFQEQQGPAQAVRGIAALLPGGGDLRCRGIQEVRGSLFPQLGQFGSSTRGPGVIGDVEEQVDDVHGFPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR2</accession>
    <name>A0A7W7WXR2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-5' exoribonuclease</fullName>
            <ecNumber evidence="1">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00977">
        <property type="entry name" value="3_5_Exoribonuc_actinobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030853">
        <property type="entry name" value="3_5_Exoribonuc_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033390">
        <property type="entry name" value="Rv2179c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16473">
        <property type="entry name" value="DUF5051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5051" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="170" mass="19585" checksum="3D5A0646927F972E" modified="2021-06-02" version="1">MRFFYDCEFIEDGVTIDLVSIGVVDEEGREYYAVSTGFDPAKAGPWVRANVLNQLPPPADPAWRSRERIKKDLIDFFGGPKANRDDVELWAWFAAYDHVALAQLWGAMPALPRMLPRFTRDLRQRWEDVGKPRLPQPPADAHDALADARHNLARWKVIEAERNRRGFVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXU6</accession>
    <name>A0A7W7WXU6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="35952" checksum="775B51D30888F45B" modified="2021-06-02" version="1">MSVTRPTTVRLASGRVSFRLHARSLWVCLVLLVVTAGALLAALVMGEYPITVADAITSVFGEGSRLAELFVDRRRLPRALTAILVGIALGVSGAVFQSLTRNPLGSPDIVGFGQGASTGAVLVLLVFSGGTTQTALGAFAGGLVSAAVVYLLALKRGAHGYRLVLVGIGVSSMLIAFNNYLVTRADLNDARAATVWIVGSLFERRWPEATLMFFTVLILVPVTLILGRALSILDIGDEGAKGLGVRVERSRLALIVVAVALTAVATACAGPVAFVALVAPQVSRRLTGSGGPGLLPAGLLGGALLLISDLVAQRLTSPGELPVGVITGAVGGVYLGWLLLREWRSGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXV8</accession>
    <name>A0A7W7WXV8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12071" checksum="59F531A8ED58ECF7" modified="2021-06-02" version="1">MTMSADDVVHLYRYILTGLPADQRDFIVDALGSAPDTAADGFDQGFALMGPDVDAYAKQGWMWYLPADLYLHSAGIVRSRYVVAILSLHSGVPAATAEATLDAVTTALLTPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY70</accession>
    <name>A0A7W7WY70_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="7872" checksum="58E98DE4CB81FD17" modified="2021-06-02" version="1">MKTLMPFVQPGHPMLGGVLLSGVARVAGEKSARDRRATTWGGKRVEQIQTTAAVRYALTVAPSNVAPSAHERST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA0</accession>
    <name>A0A7W7WYA0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxychromene-2-carboxylate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22849" checksum="3EC89845F88D62A1" modified="2021-06-02" version="1">MSAEAATKVDFYFDPICPFAWITSRWILEVEKHRDLDLKFRVMSLAVLNAGRDLNPEYRKGLENAWKPVRVAIAAEKHHGNEVLRDFYTALGTRIHNEGNKNYAEVIKLALEEVGLPAELAAAADGTEYDEDLKASHHRGMDPVGEDVGTPTIHIEGVAFFGPVLTRIPRGEDAVKVFDGARALASFPEFFELKRTRTGDLHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA3</accession>
    <name>A0A7W7WYA3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="19151" checksum="CAA30FA379F4890C" modified="2021-06-02" version="1">MPELLPRRRLDQPRQPARFRLSLDPEAFGRFSERLARFLGTGKFLFWQTLLVLAWITLNLVAVEYSWDPYPFILLNLAFSTQAAYAAPLILLAQNRQDDRDRVSLEEDRTRAAQTKADTEYLARELAALRLAVGEVVTRDYLRSELDRVLRKTRRRALKDSEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ22</accession>
    <name>A0A7W7WZ22_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall synthesis protein Wag31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Antigen 84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DivIVA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="44380" checksum="0F06204CABA7033E" modified="2021-06-02" version="1">MERVGFETRNHSPAHPAPLLSAQDLGQVAFHRPPPGQPGYDEQDVDTFLDRIEETLRGRDDVTEEQVRRKRFRPARPGYHAAEVDVFMDLVAETLKSTPQRRQAAAPAHGAHATTTGMRPAPQLTPQDVRGVRFHKPRPGNRGYHEGEIDAFLVRIERTLSGRDVLTAREVQDVEFSYAPTGRVGYDEEDVDTFLDLVVVTLERNPLPPPVRPRPGPGSRPLTARDVRTVAFGKPPRGRRGYQESQVDKFLDRVENALLGQDDLSARDVREIRFSRPVFGRRGYDETEVDAFLARVERQLSDSPAPGALPAITSWKQLRAVRIPSARPDQRGYRTSQVDRALEEIGIALDGMVGATSSEVMATRFALAMTEGQGYDRAFVDELLPLLAAELRRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ23</accession>
    <name>A0A7W7WZ23_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase</fullName>
            <ecNumber evidence="2">5.3.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.18" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="26754" checksum="0EB777698CEC94C8" modified="2021-06-02" version="1">MSELLVEDAEGVRTLTLNRPDSYNSLTVSLKERLRDVLAETAADDRVRAVVLTGAGKAFCAGQDLKEHARLLAEGDPAPLKTVELHYNPIVESIIGMPKPVVAAVNGMAAGAGASFAYACDLRVAAAGARFLMAFANVGLSADSGASWTLPRLIGRGRATEMMLLAQPVDAAEALRIGMVSQVVPDGEALSTAHALARTLASGPTAAYAAIKEALAFSGALSAALEVEARTQAAAGGTADHRAAVEAFVAKRKPTFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ63</accession>
    <name>A0A7W7WZ63_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan/LPS O-acetylase OafA/YrhL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="12"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="531" mass="59163" checksum="F91E5C9E95C5E26B" modified="2021-06-02" version="1">MAGPTTPKSRIAFIDIGRAAGALLVFYSHIAEQWVAKRETGPTPVVDFLDAVGSDPMRMGFQGIGQIAVPFFFLVSGYVVTPIALRQGGWRFTVNRLIRVHVPMTFAVLLTAALVLLGVGTLAGASAQTVTWTTVLTNSLVVNYVLVPQVVLVGVAWTLVVELVFYALLVAVLPVLRRWTWAAIAGQLTFVFVVMMSMREFGPSWFLFAVNACYLPAPILGQVVWATTTGRVPLWLGMVFGSVAWGLYVLGDHLGIGRLDGSYPLALAVALLFFLLGMFAEPRLRERRVWTALSERSYSLYLLHGIVAWALLELLRPTVPLWLAVPVAVAATFGVVEVSYRFVERPSHALARRWSRPARTRWSFEEGLTREIEAIKEEVARPSDATVPIPRLETADTGTSQAPARDRVGGRLRPASGRDVLAEPAQRDERWLPPARDRAPADRDDDYLRRVPDRRDGVPGRTEDRHRPTRDRHDRHVPVRRGEVRSTQPDEDPMRRRGARTGEESDERGRRVRRPDGVPTRALPAGRDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC0</accession>
    <name>A0A7W7WZC0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine N-glycosylation enzyme membrane subunit Stt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016566">
        <property type="entry name" value="UCP010219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11361">
        <property type="entry name" value="DUF3159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22787" checksum="8C8C9BA03FA59ED6" modified="2021-06-02" version="1">MTDTRPETLGELLGGRGGALDASLPPLLFAFGWLLGGQSIIGGAIAAVACGVAIGVVRVVRGDRPRAVLVSVALVVLAAYIALQTGRPEDFFLLQIFLNVGSALAWAASIVIRWPLLGVVVGLLTGQKFRWRRDPDLMRAYRVASWAWVGQYVLRVVVFGTLWLSGQVLVLGFARGVMTWPLQLACIAVSWWLIRRTLPADHPGLRHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZV1</accession>
    <name>A0A7W7WZV1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="112"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cyclosporin A binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>cyclosporin A</name>
            <dbReference type="ChEBI" id="CHEBI:4031"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001467-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19565" checksum="9AA615C5F70974D6" modified="2021-06-02" version="1">MTDSKESLVGTKVTATLRTSRGDIRITLFPDHAPKTVGNFVGLAEGTKEYFEPNAKGEPTGPFYDGAIFHRVISGFMLQGGDPTGTGRGGPGYKFADEFHPELQFNKPYLLAMANAGANTNGSQFFITVGATTWLNFKHTIFGEVADQESRNVVDAIGATETDGGDRPLTDVVIESVTIERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXC7</accession>
    <name>A0A7W7SXC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030712846" evidence="2">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="32295" checksum="316994FD6CDD1861" modified="2021-06-02" version="1">MRNGRRTTFAGALAVLAAGALAAMLVSTDGQRPVDARRVSPSQTAQTELSATYTTNVEATRPAPPPPPPPVNAQVDRTVPVRPAERPRPEPSTTPTEPSPHPTCRPLPFCPSWPEPDDEEDDVEDEQDWPDWPEWPDYPDYPGLVPDPNWYPGSVPGTTSGSTPDSDVGSYSASGAYSGPTPYYGLTIYSVPGTYPVPGAYSVPGAYPVPGTYSVPGTGSRPRADRHPDPTRRPTQAWDPGQARHPAAGEVAGRPGQRPDRTSGHADRHPVAGQDRPHRPQCRPADRGTRGVPIPGRRFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXW8</accession>
    <name>A0A7W7SXW8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="25959" checksum="11808B56F84E098F" modified="2021-06-02" version="1">MQRTTRGGRRHGRTGSVSVAELIRRQPTSLRAPVRRPAAVEADVEPHSRPTNRTARTAGFATGAFVLVAAVAAATFLAHRREPGPTNPATRSPVAISGAPALRPDKLWAELGGTPASLSVAPFADFRIDEAAVVVPPPEATAGSKPQVDIVRRFYELLPAKPAAAARLLSPDLVGTSPGEFVAAWEGIKAITIESTSLRPDGAVHAAVSMQGRSGDWIRVEQLFWLTDTTTPRIVGTEVISAQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXX8</accession>
    <name>A0A7W7SXX8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="36859" checksum="54FCF66E46B133B7" modified="2021-06-02" version="1">MRGSTTATVAALGVGAAGESTSAPTRVLPVRGELAGLLPWGGLRRGSTVSVRASASLLLTLIAAATAEGSWAVVAGLPRCGALAAVEVGVAVHRLALVPRPGRDRGEVDRTVAALLDGFDIVAVATPVSAASARKLSNRARVRKAVLVPFGLDWPGADVELTPSFGPWNGLSPDGGTPLRTRTLTVHATGRGAAARPRSTTFPLLLRTRVLHPDTLKVPRPHKRASYTFRHHEMCTRTPRVVRSGTANHALGACLPEACGPQGGEHLRVSPRTREDGSRPRPLARTFTRRPLHPERASPPLGHPEIRTRAVRDGAVRGSASRESCVRTPRVVRSEPRIAAFRNLYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYF7</accession>
    <name>A0A7W7SYF7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="793"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="823"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="904"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="940"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="335"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="684"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1041"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1238" mass="130340" checksum="E569CAB0AEBD9ADE" modified="2021-06-02" version="1">MTGTDGWVRRLARACGRHRALVVLSVAAAVVGVGFQAVTPLLVKVAVDDSVAGRTDRLAWLAVGLVALELLTFGTAFVRRYLGGRLAVEVQHDLRQAVFRAVQRLDGPKQDALRTGQVVSRSITDLQLVQSLLSMAPLAFGTVVFTVVSLGAMLWLSPTLTLVVLVVLPAIAVVAGRSRLTLFPATWSAQQRAADVAQQVEETVTGVRVVKGFGQEAREVARLEARARVLFAERMRAARLTARPSATLAALPYLGQVGMLLLGGYLVLHGQVTLGTFLAFASYVAALVGPTRLLSNLTVTAQLARAGVERVYELVDSQPDVVDGGRELPDGALAVALDGVGFGYTRSEPVLSDVTLRVAAGETLAIVGTAGSGKSTVSLLLPRFYDVHAGSVSVGGVDVRELRLGSLRRAVGVVFEEAFLFSDTVRANIAYGVPDATDEQVEAAARAAEAHGFISALANGYDTVVGERGLTLSGGQRQRVALARALLSDPRVLVLDDATSAVDTATEAAIHRTLAAVTASRTTVLIAHRRSSLALADRIAVLDAGRVVDVGTDAELHARCALYRDLLAGPGEAIEQVDRRAGVPLEPGPDGYTPELWPESEEDELAVRAANRAVRTARPSRGHRGGGGTTALVGATPPTPELLARIHALPAAADEPELRGEDPRAPDPGFRLWTLLRPVRLAMLAVGALLLVDSALAIGLPNLVRLGVDRGVVGGEPGWLWAASLGGLLLVVAGWLSSAAGTVVTSRVGERLLYLLRVRSYAHLQRLGLDYYEREAAGRIMTRMTTDVDALSTFLQTGLTTFVISFLTVGGIAVALVVTDLKLALVALAVLPPLIIATAVFQRLSSRTYAEAREKVSAVNADLQENVSGLRVSQAYAREDRSAAAFAERSDEYRRTRIRAQRYIATYFPFLALLSGVAQAGVLVVGAYRVAVGDLSPGVLLAFVLYLGLFFAPLFQLSGVFDGYQQARVGLSRIGELLRTPTSVPPAADPVSVTSLRGEVELCGVTFVYPGTSVPALDAVSLHVRAGETVALVGETGAGKSTLVKLIARYYDVTDGRILVDGTDIRQYDLGELRARLGVVPQEAHLFGGDVAENIAYAEPDASRSAIESAAREVGALPVVAALPSAFGQQVGERGQNLSAGQRQLVALARAELVSPDLLLLDEATAALDPATEAAVLAAGGRLAASRTTFVVAHRLATAARADRIVVLSGGRIVEVGSHSALLAAGGVYASLWAHGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYI8</accession>
    <name>A0A7W7SYI8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="485" mass="48430" checksum="B45BBD992AB28DB3" modified="2021-06-02" version="1">MADAQQIDLVLTDTQNWASRSHRELYDSVHHNNDPGRTGELGAEWGQFGAELTESARVITDRITASESGWTGVAADTAREAIGRLAEWVTRTAETAVLVGDKVRDQSQVMAGTRSAMPEPVEFSWDAATGVFTGGGMQGLLSSAADVSMANERARLAHESAVAVMGAMEEQSRAIDRTTPRFTLPFNPVTGRDEQPPPVNLSAFTETVVGRTTASAYSPQVEAGAGPRYAPAAAYQPSYQPGGSNGGYVPGSGSNGGYVPGGGSGGYEPPPSNYQPRGTTTTSNATPQVPVAHPYRPPTNQPGPVYPTPVQPDYPANRPGTYPTPRPASYPTTPGVPTSGTRPGIPGAPGVPGGRGGVPSGFGGGGGGGGYGGGGGYGGGGGYGGGGGGYGQPGAGQLATGGSTGQLGARGPMPAGIAPTGGPGAGSASGMAGSPMGGPGGAGGRDDDQERKSAAYLRGEDIFEVPGADLPPSVIGGTPPTGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYL7</accession>
    <name>A0A7W7SYL7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7697" checksum="680801BBB415D959" modified="2021-06-02" version="1">MSMTAEEKPIVGVKFLTVAEVALVMRVSKMTVYRLVHSGELPAVRVGKSFRVPEKAVHDYLRNAYFDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX7</accession>
    <name>A0A7W7SYX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="45864" checksum="91B26D86ADE1D42D" modified="2021-06-02" version="1">MRLPAHVDSTAQVRGALPWLAGPGLPAVGTVVGRERFSGGVFCFDPWRLYARGLLQDAGIFVAGVIGSGKSALAKSLCLRGVAFGRRFAVPGDIRGEWVPVVEALGGRVLRLGPGMPERLNALALPPKPEGMTDGQWWPVVRTHWEGLLEALIRTLLPGQRALTMDERTALETALTAASRWSGDLARVRPVHLGLVGSLLLDPTREMAAEHRVGLGVLRERLHEIGLAVRALTRGGFAGLVDDDRPGNQMDWRDTATVVDISRVKTSDLAVALVMATTQSVIELAFAHRPGQRFTVYDEAWRLSAFPALMARTNAGQKVSRATGNATIIVCHRVSDLFGGTEESRHYGQALLADCGTRVLYRQRGDVASLRLSERQASLLPLLDKGTALWTVDGRPFLIDHVVAPREWPLIDTDQTMLGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ49</accession>
    <name>A0A7W7SZ49_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7434" checksum="DB80E5DE8A772FD7" modified="2021-06-02" version="1">MSTHIGYSTSSFARIEGDAPISCHIVGDEAHLTIGGGALDLVITKTALVDLTGHLVRARDELTADEQLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ99</accession>
    <name>A0A7W7SZ99_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="18538" checksum="9DC4146852F7361F" modified="2021-06-02" version="1">MITESTSAGLLADADELADLLLTVVAGGSSVGFLATLTHAEAVTWWRGLAAPLANGALTLWVARAEGRIVGTVQLRHGTMPNGTHRAEVAKLMVAPSARGWGVGRRLLDTAERGAARLGRTLLVLDTETGSPAENLYRSAGWTEVGRIPDFAADPGGALRPTTLFYKLATAGTPPTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T016</accession>
    <name>A0A7W7T016_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="68"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31502" checksum="4C2091B83FD4D41A" modified="2021-06-02" version="1">MSGDWERRLADLFAFARRRLEGEYEIDEFGFDRDLTANVLMPPLKPLYEKWFRVETIGLHHVPAEGGALLVANHSGTLPLDALMTAYGVHVDHPAHRHLRMLGADLVFRTPVLGALARKSGQTLACHPDAERLLRSGELVGVWPEGFKGIGKPFKDRYKLQRFGRGGFVSAALKAGVPIVPCAIVGAEEIYPKIGDIKPLARLFGFPYFPVTPTFPWLGPLGAVPLPSKWYIEFGEPIRTDGHGEHAADDPMLVFNLTDQVRETIQQTLYRLLTQRRNVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T077</accession>
    <name>A0A7W7T077_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="72" mass="7519" checksum="48C39DD06EA66C09" modified="2021-06-02" version="1">MFPLYEIDTSSTPSRAAAQCSTAATVSLKKRSPTSTNAKTVPATRDRAITVTAPAAHANAAEVPKSRRCKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A6</accession>
    <name>A0A7W7T0A6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030743440" evidence="1">
        <location>
            <begin position="27"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="32"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="255"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="755" mass="83008" checksum="C30611A0BD8FE657" modified="2021-06-02" version="1">MRVKVLSAIWSLLSALVIVVPVAETADTVESVDTFIGTQDEGNTFPGASMPFGMTHSSPIGSHYAGWRYDDPAIRGFGHFFLSGAGCYEQGGLVSILPTTGLPRSFDHRRYAVPYSHEDEVGKPGYYRVRLGSGVLVESTATTRTGVERFTFPAGTTAHVLVNVGQANDKEPVSGSSVRVVGDRTLTGTVTAQAFCGGRPYTTYFTTTFDRPFARTGNWGGESGGAGLRGQWVSFADGAPVTAYTALSHVDAEGADRNLAESRGMTFDAVRAAARAAWRRELDSISISTADATDRTVFYTALYHVLLQPLTGNDIDGRYRGFDNRIHHADGWTYYEYFSLWDTYRAQNQLLALLRPERARDIGRSLLAIEEQGGWLPRWAYANQETNTMTGDPVTPFLVDLWRFGALEGLEERAYAALWRNATSVPPASSPFEGRSGNPSYLSRGFVQYDKAFPKKGQDVDPHHGASATFEYALADCALSIMAAGLGHHEDAAVLRGRGRNYRVLWDPSVTDRGFTGFPRPRLADGRWLEPYTAQGPEGFHEGTAWQYQWLVQHDIPGLVDLLGGQDRALARLDDFFAYADLVADPARTVREKWVVGPYDYYDQFRYNPNNEPDLHAPWMYTLIGQPWKTSAVVRAAQTLFVAGPSGVTGNDDLGQMSAWYVFSALGLYPVEPGTGRYVLHAPRFEEIVVEGGPTITAPGADPRVLQYVEGVRDRVWVDHAELVAGVRLDFTLTDDPARARWGTSPESRPSAPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q6</accession>
    <name>A0A7W7T0Q6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="42507" checksum="790B86FFD4805DCB" modified="2021-06-02" version="1">MSRGWGRLQAVAVSGSVAEGLLLTLLPLVLVTITDDPREVSSVYVVGQSPWLLLSLFAGVLIDRVRRRTVLVSACLVQVAAAAVLAVAATTGALSLALIVAVAFVVTTAQVLSHGVMGAMLPEVVDDLEAANARLMVIDQGVVRFLVPPSAGLLVGWGFGLPAGLAVAAAAAATVLALGLPSRAVVRSASHPVRDIAEGLRYLLGNRLLISITIAVALGSFAASAEVSLFVLYAKDVLGLGAVGYGVLLGCMALGWAVCSPVVSRAIARMGYARSMRVAQVGMVVGHLGFVVLPPWAWAIGVLMFAQSGIVLLWNVCSMSSRQRFTPTALLGRVLTSHRALAWGFAPLGALAGGFIADHWSLRAVWAMAAAVQVVALLVCLWQVSVGAFARAERVAVQGRRPGSLSWGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R1</accession>
    <name>A0A7W7T0R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="47158" checksum="8B169C67418E81A4" modified="2021-06-02" version="1">MTRTHAGRPDGRPDGRHAGRHAGRTAAGRPDAGNRPDRPHHDCPHHDCPHRGCRPGRHAAGSHRNARRPGRPEAGTHAGTHHARRRNAHHRAGRRRRTDRRRAGRRRRTDRRRAGRRRRTDRRRAGLHRATRRTASHPHGRPAGTRHGCHRIPGCPGSGRTRLGCHRHGRRAAGNPRAARTGTHRGHRRSAHHRGRTPDARRAGTHPARNRPARTGRDRNPCCRPAGIPGRHRNGRPGGNLHAHRTDRNPGRPGGIHPGRHGNGRTAPDPNRAGRSHPAPNPPDLNLHDRNPPGRRAGNHRGHRGGRHGGSLHAGRPAGIHRGRRRPEGGIPVVHHRKTHGRHAAGRRDAGNHPDCRHHDCPRPGRPAAENHRTARHHESPGHCCCAYDRLRHGHRRIGAVGLPGHADGRRDDPRTWTPESSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T140</accession>
    <name>A0A7W7T140_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010697">
        <property type="entry name" value="YspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38440">
        <property type="entry name" value="PTHR38440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="16880" checksum="7F2F6934C88D0D1D" modified="2021-06-02" version="1">MRVGITGHGNLVPECVDGVRAALRATVEQEVPGGSSLVGVTCLAPGADQLFARVVLDLGGRVEVVLPALDYRDRMKPEKRPAYDELLAKAHVVSVLPNELSGRHAYVMANERMLASVELLIAVWDGNPPDGRGGTADVVETARASGVPVVVVWPPGAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T186</accession>
    <name>A0A7W7T186_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019966">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv3369"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03667">
        <property type="entry name" value="Rv3369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15882" checksum="28291F9C1735D407" modified="2021-06-02" version="1">MSLSLPEPGTELGDRVARRLRDETIGWITSVDGSGTPQPAPVWFLWRPEDSSVLLYSMPTAKRLARLRANPRTAFHLNDAVGDDVVVLLGDLVERPDLPGAADVPEYEAKYGDVARKMFGSSEEFAARYSVPLLFVPERFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T188</accession>
    <name>A0A7W7T188_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphosugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="31"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="24950" checksum="E440F0CF6B036A34" modified="2021-06-02" version="1">MTTDFGSLVRDHLTRVETHNAAALDDVVELVLAAIRADGTLLAAGAGHSLAAVAETFYRAGGLACVRPVYHPELLPMHGAVASTVAERRSGLAAEVLEKTPLAAHDLLFVFSTSGVNPYPVELARLAVERGCPVVAVTSVAASAAAPRRAGSTLAETATVVLDNLVPPGDSTYPADAPVTSAISTIATAFLWNLLLARLLDKAAEEGFDLPFWRSANVQGGDAANAAFLEKYGPRVPELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A2</accession>
    <name>A0A7W7T1A2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="43025" checksum="ED79A008D773F844" modified="2021-06-02" version="1">MWDGDLTGEVLNSRYAVGGLYGAGGMAEVYRAFDTRMDRRVAIKVFQGDAASEERVRLDREARMLASLHCPGVVAVYDTGIVRGRPYYVMQPIDGGTLRRRMREPIAPSVVARIGAQVAEILAAVHAHDIVHRDVKPSNILLDLGERRAYLADFGLALQGQLTRVTRTGVLVGTAGYLSPEQVRGGDVTAASDVYALGLVLLECLTGWPEYPGGDTESALARLHREPCVPAGLPASLTDVLVAMTSSVPGNRPTADVCVRRLVRAERDCLGLEPLSGDGVVTRPEPPADRRRSVRVLAGVAAVVGVLAVAGALLCRGTPPVDERSAPGIAATRTSATTPGSSTVDLPGAVPEEPVAETTPVRSGAAVPETLPPRIGSATVVEPTEGTTAPEPPKPTVPAKGKGNGKGKPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H5</accession>
    <name>A0A7W7T1H5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18980" checksum="B508E7800B400B8B" modified="2021-06-02" version="1">MGNPSTPREFAERIVSLGLAAPEAAAEFADWELDEEDDPLRTYHEILIELGLAVQVPVGDTDDLERTYADVLSEVVGLTGGAVEVADVRLADDLRSIAFTIDGVRKEWHTEHHSTRHLDQLAIYEFVSLFDPPDGRRFRGLGLADDYDDPVYLLATEEHARVLADEFGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1J6</accession>
    <name>A0A7W7T1J6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="32680" checksum="5CA308E363E80E5E" modified="2021-06-02" version="1">MKSGDRVVDVRGLRMRYGSRDVLDGVDLAVDAGEVVALLGPNGAGKTTTIEILEGFRTRSAGEVRVLGVDPDHGDETWRAALGVVLQSWRDHGRWRVRQLLDYQRSFYPPYRDRLPGTDEVLGLVGLTGQADARIATLSGGQRRRLDVAVGLVGLPDLLFLDEPTAGFDPAARQEFHDLVTRLSGVDGMAVLLTTHDLAEAERLADRILVLAGGRITAEGTAAGLAAEASAQTEVRYLLDGTSHVVSVADATEYVHRLFLDHGLAVRDLEVRRPRLEDVYLDLVRRWEGGAAARGESEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T4</accession>
    <name>A0A7W7T1T4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="31" mass="4095" checksum="23026A5F364499DA" modified="2021-06-02" version="1">MRDKIWYILTVPRRNRRHIERRCVPMRDKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V4</accession>
    <name>A0A7W7T1V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22006" checksum="960DB09989F8C94E" modified="2021-06-02" version="1">MTDFCSTPTCASRDTPPWAAEGATVCARCVTRLREDCTAIPTLWRPWTATAALYPTRAASGRRAPGVAPAAPANLVALVMTDVRTSWDEPGDLLNPQRALAEVSARILRDGAGQARALGSLSVAESCAVIGVGPLHWWALAQEWAGAMCWTVRLVRHQLGGLAHEVRPRPVGTCEGCQGPLWVSGMSVVCRACRTDRSGFELLGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T242</accession>
    <name>A0A7W7T242_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15002" checksum="96C41ECE62B5AC7C" modified="2021-06-02" version="1">MPHEAIGSQLRALRLAAGRTVASVAADAGLSVPYIANLENGRGNPTMSALSRLATALGRDLVIGFDGVAGEEGPLPPDLAKLGRSRRFKSAVAALAEHRGQDVTAVATHLLGACRRLGHVLDEPSEADWFRVLDAVLLIAAHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D6</accession>
    <name>A0A7W7T2D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="6091" checksum="CC04160DBBC846C3" modified="2021-06-02" version="1">MCQRVTCRRCGKPTHAGCGLHVEQVLVDVPRARRCQCAPPRGLRWRLGSFSGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T303</accession>
    <name>A0A7W7T303_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="30355" checksum="A3D86DBC95AA4AE3" modified="2021-06-02" version="1">MSAPQAPEHDGRFKVRLTNFEGPFDLLLQLISQHTLDVTEVALHQVTDDFIAHIRNLGDDWDLDETTEFLVIAATLLDLKAARLLPQGDVEDEDDLALLEARDLLFARLLQYRAYKQVALLFGELEQGAYRRYPRSVALEERYEGLLPEVMLGVDAAKFALLAAAVFRPKPPPTVSLSHVHQHRVSVREHADRLREVIAARGTVTFAELVADRTETMEIVAGFLALLELYRERVLAFEQPDPLGELTVTWVGGTVEEARAAARDEDEEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T305</accession>
    <name>A0A7W7T305_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="494" mass="50844" checksum="CF3692BD0AD485A0" modified="2021-06-02" version="1">MSAPMDAPPRPTGRTWFGIGVVLLAAFMGQIDMFIVNVASPPIQADLDATFGQMQFVIEGYVIAYAAGMVAGGKLGDRIGRRKVFLYGVAAFTVTSLLCALCPTAPLLIGARVLQGAAAAVLMPQVLSIIQTTFPDARDRRRAVGAYGAVIGLGVIVGLIGGGLLLQLDVAGLEWRTIFLINVPIGVAILVAAPTVRESRGPAAAPLDVVGTVLTATALPVLLIPLSLGPEHGWPPWIWPWFPVAALLTAGLFRYETRLAARGGDPLLPPGILRRPGFPTSMAAVTVFFSGNAGYFLVLTYHLQSGLALGPLDTGLVFVPLGAGFALASVAGRRLAERHGARVLIAGALLMAISFVPIPFIVHADAGVQSLALGAAIGLSGIGQGLVVSPLIAIVMAQVPDEMAGAGSGVLNTVTQAAMALGVAVVGTVYRAVLGANPQRTGDSVPAADFAAAFTITCVLLCLLALATAVLSGLLGRMLRRRDVTLKPAAVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T317</accession>
    <name>A0A7W7T317_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme related to lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="131"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25717" checksum="1DBDC5FE65825F7A" modified="2021-06-02" version="1">MALRLVQVNLKARDDAALGRFWAAALGWAVVGSAGGATPVHPAGFAWPDPVAVSIDVIAVPDPEAVRGRVHLDLATTSAAHQVELVARLVESGATHADIGQGDVPWTVLADPEGNVFCVLEPRPVYQDTGPIAAVVVDCADPRAMARFWGAATDWTTHEVGDDYARLRSAAGVGPYLEFLRTPDSSDHHRLHLDLAPYPDDDQAAEVARLRALGAADLDGGQGEVPWTVLTDPEGNGFCVLAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3D3</accession>
    <name>A0A7W7T3D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR02246 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011944">
        <property type="entry name" value="Steroid_delta5-4_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02246">
        <property type="entry name" value="TIGR02246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13423" checksum="BD0A059C3E803CF2" modified="2021-06-02" version="1">MDDIRRTIADAERHQSDLDPFVALHTEDVVVVNLAGRRVLGRAALRDAMAAALDSPLADVTTRSDVEDIRLVSPDVAIVSCLKHVSGLADELTARLTYVLVRQPDRWRIAVAQTTPITAPFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P3</accession>
    <name>A0A7W7T3P3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein implicated in regulation of membrane protease activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="14291" checksum="575A92F71A2262BE" modified="2021-06-02" version="1">MLPAIIWLVLGVVMVVAEVVSGDFVLVMLGVAALGAAGASALGADLVIATVVFAVASLGLVLGVRPALKRRLELGTGHRSGIDALPGSTAVVVSRVDGRDGRVRIGGDIWSARSIDHEVIEVGVEVTVVEISGATAVVMSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S1</accession>
    <name>A0A7W7T3S1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase S</fullName>
            <ecNumber evidence="6">3.4.11.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.24" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031323529" evidence="4">
        <location>
            <begin position="29"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="5">
        <location>
            <begin position="536"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="584" mass="59325" checksum="E13C0617975CD059" modified="2021-06-02" version="1">MKHRILGAAVALVATLAWVTGPTGPALATPEQQPGAAALAPPDIDVAAVQSHLNQFNSIATSNGGNRRAGSGGYTQSLAYVKGKLQAAGFTVVEQRCSSCTYVSNNLIADWPGGDVNQTIMFGAHLDGVSAGPGINDNGSGSAVLLENALQLAARKPTLTKHVRFAWWTDEEQGLNGSKYYVSQLGSARSQIKAYYNFDMVASKNGGYFINNINTTAAAPLREYWTSLNLQPEENVEGAGRSDDYSFQQAGIPSSGYATGASARKTSSQASKWGGTANSAYDSCYHSRCDSTSNINPTALDRSADGIAYTIWKLAVNDNPTNEFSLSLNPSSGSIGVGSSGTFTVNTTTTSGSPQNVSLSASGAPNGVTVSFSPSSVQSGGSSTATVSVGSSVARGNYQITVTGTGTGTGAVTRTATYSLTVPSDNPGNEFSLSLTPSSASVAVGQSGSFTVNTATTSGSAQTVALSATGTPNGVTVSFSPSSVQSGSSSTATVAVASTTTAGTYQITVSGAGSVTRTATFTLTVTGGDTGGCGGLQAWSASASYVPDDLVSHNGRKYKSTWYSAGAEPGAPGSWAVWQDQGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Y2</accession>
    <name>A0A7W7T3Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="31870" checksum="41E1D1A5D4ED46DB" modified="2021-06-02" version="1">MTAPERSRLARERLSRELRRLRTEARMTGTATARATGMSQSKLSKIENGMLLPSVADVERLVNELSATRETRLELIELARQLHAEAETRRVVLHRGAHRHQQTVARIEARATTSRFFQNAGVPELLQSESYRRVVLAATPPHEQDTAIATLRSRRARMDDLGKRFVFVLSEAALRWRMGSADLMCEQIEHLTQTMRRPNVQLGVIPWTADANLVALHGFQVYDERFVTLSVLTGNATITDPLDVREYLALFTRLERLVMRGEQLEDLLEQISRDHRKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E6</accession>
    <name>A0A7W7T4E6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="370" mass="40637" checksum="21747EA3590B4821" modified="2021-06-02" version="1">MDDLYDRLRRRVATNARIVVDTCIAELPEYAATIVDHRDLAGMLDFAVFIRRRTVDLTAADEPMTPEDLATIASIGRVRGERGMPHAVLPRVLALHAAATFREVQEASGARDLTDTMQVLSWLSDQGSAGQRAYTLGFLNGQRRFLSPTGQVRRLAELTLAADPAAASYGEDIGVPLPDRIRVVVARCTPPHPVDEVIETVWQRHRVPATWTGPHELAVVLPAEPDTLAATVTEDLNATLGRPCLGTATATLSALPDAFSLARRVSTVAPGGFLYTIADLLLEVAVREMPEIERWLDGLAARLSSGPDLIATLDVYYRCDLNRAEAASTLHIHPRTLDYRLQRIRDLTSVDPHTTHGIRVLSTVVTRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J8</accession>
    <name>A0A7W7T4J8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5102" checksum="DA7583860B4BCEC8" modified="2021-06-02" version="1">MADPADLRAVVDRVAADPLIRHRVDRMRDAVHAAGGVGLAADLVVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N0</accession>
    <name>A0A7W7T4N0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rho</name>
        <name evidence="9" type="ORF">F4559_003862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="8">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="39826" checksum="60CEF37351F5EA37" modified="2021-06-02" version="1">MSTHQSTMESALAGGVLDIADNRAFLRTQSFLPEPDDVRVPIRLVRQHGLRRGDAVTGQADARELLTVDTVNGLHPRHSPARPVFQDLTAVHPTDRLRLETDPHELTTRVIDLVMPIGKGQRALVVAPPKAGKTTVLRSIAHGIAKNHPECHLMFVLVGERPEEVTDLARSVPAEVVAATFDRPPRDHTILAELAAERARRLVELGRDVVILFDSLTRLGRAYNLTATGSGRVLSGGVDSTSLVPPKRFLGAARNIEGGGSLTIVATALVDTGSVGDSLIFEEYKGTGNAELRLDRALARRRTFPAVDVTTSGTRREDLLLTEAELRTTRALRRALDKREAPVEALLDGLRKTHDNAEFLGRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U2</accession>
    <name>A0A7W7T4U2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="517" mass="55544" checksum="41D1693933423A3E" modified="2021-06-02" version="1">MAEQGDRLGGRYRVTGVSGRGAVGVVWHAVDELIGREVAVKELRPPAADRAAAAERALREARNLGRLNHPGVLAIHDVVPPSSQDEAVYLVVELVRAPTLADLVASDGALPPNRVAALGLRVLEALTAAHDLGIVHRDVKPANVMVLTGDRIKLVDFGIALAAGDERLTRDGVVGSPGYLAPELFEGADPSPASDLWSLGVTLFHAVEGTEPFDRGTAASTIHAVLYADLPRPTCGGPLAEAVTGLLDRDPARRFTAADAVALLEKGSADDGGPAVAPRPRWEASATTVSRVEPRRRHPDRPAFPVVRPGWDLAFRWATGVGIVAYAVFVAWRLVDRVADGDVRVRLLAVGAAVLFGLAAHMRIIGLRWHSVEVSREGLTFLRAPRGHRFDVAWERVRSVDVADVAHRTRSGSAAHARLTVRMRVTEERVGWNHSGFQPVAKVGDTITATLADLRGPSADVVAELRRFAPPVVTVSGPADGIRPAPEVVDRWYLLLPRLVLMFGLLAGLTWFFTRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U8</accession>
    <name>A0A7W7T4U8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="29844" checksum="9D934310083B3E4E" modified="2021-06-02" version="1">MLALVAALALTVIITGVLLRLPDRKTAERVPTLDGVLGDFVAALSEDAPYRPPPASDRERFADALSRLDDGVLRDLGARVDRAVDQATGRPYALVDARMWGLYVVDLSAPVRLAVQVPHPANDLRTDGLGLDLFRRVPGAVLSVAGTHRRAGDGAGDVAHRTDSVFHAVAAEHTGRGLAQVQVHGFDDASLPDVDVVLSPGAARDGDHLKGVADRLDEDLEVCRAWSRDCDDLEGRTNVQGEEAAEHGVPFAHVELSRSVRESASSRRQVVDALAEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z0</accession>
    <name>A0A7W7T4Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="161"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="38963" checksum="0E41FBA32875C25D" modified="2021-06-02" version="1">MITDEFDTVAHDLLAIRSTTDRPDELRRALDLVLDVVGPGFTVERFESGGKPSALVHDGARRPFDVILNGHLDVVPGADEQFRPCREGDRLYARGAQDMKLTALVMAQVFRDLGPGRPVALQLVTDEEVGGYHGTAHQLAHGVSAGFAVIGEHSAPRVVTESKGIASVRLDARGRAAHGAYPWLGDNALLTLMRAIDALLAAYPVPDAEAWRTTVTVSRIVTPNETLNQVPAEATAWLDVRFPAEDTGFAGRTPEEVRAHLAALCPPGVEVSVPTLESPHRADPDGVHVRALRAAARDVGFSAELLRKHGAADSRFFHARGIDAVIFGIGGDGQHGPAEYADLTTVEPYRRALSGFLRALPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T502</accession>
    <name>A0A7W7T502_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="29"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="20879" checksum="68D15EECED6DC17F" modified="2021-06-02" version="1">MKLASDVRACMIRAYRGRITGWAVADFLFFWGHRGEGIGRWCLSQWWPTRFTADGRVFASAEHYMMWRKASLFDDHETAGKVLDAATPDDAKGLGRRVRGFSDEVWVEHRYGIVVDGSVAKFGQRDDLRAFLLGTGDRVLVEASPVDPVWGIGLAADDPRATDPARWPGLNLLGRALGDARTLLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T593</accession>
    <name>A0A7W7T593_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate reductase delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23755" checksum="A1942C25B8496478" modified="2021-06-02" version="1">MTVTGTHRAAAWQVQSLAMSYPDEQFVDRLPLLRAAVRTLPEPLAAPLTAFFDHVAATPLTDLAADYVATFDHRKRFSPYLTYFAYGDTRKRGMALLRFKHAYRAAGLELDDSSDGAELPDHLAVVLEFAATGDPVVGQRLMIEHRAGLELIRLGLRETGSPWAHVLQSVSATLPPLGRHEHEAVARLAAEGPPEEEVGLAPFAPPEYMPQPQGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U0</accession>
    <name>A0A7W7T5U0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16475" checksum="AD16CC91A94DE6CA" modified="2021-06-02" version="1">MTTTLHTGLAPAKGLIVVSCSREKLVTTTPVPAAELYQGALVPRLRGLAPEYRARVRILSAAYGLLRPDDLVGTYDSKLRTLGAAVALRSRVAPHLDLDLRTVRHVLVALEPLYQSAVSCLFDRMPECITLLPDPLDWSGTSAVLSEWGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T677</accession>
    <name>A0A7W7T677_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (DUF305 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031138028" evidence="1">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18338" checksum="18DB78778F290DC5" modified="2021-06-02" version="1">MIRKFLVGAATAALALSALAGCGSDAHNDADITFATGMIPHHAGAVEMAKLVPARSTTPAVVDLAKRIEKAQQPEIDMLTGWLDEWGAAHGTGHNGHEGMADTDRLDSLSGPAFDREFLDLMIVHHEGAVAMAGDEIRDGKHPGARELAQRIVTDQHREIEEMRDLLKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6R2</accession>
    <name>A0A7W7T6R2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="136"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23615" checksum="824B00A2E94ED93F" modified="2021-06-02" version="1">MHVVIMGCGRVGSTLAKALERLDHQVAVIDKDALSFRRLGTDFHGRQIVGNGFDRQVLIEAGIERAGAFAAVSSGDNSNIISARVARETFGIEAVVARIYDEKRAAVYERLGIPTVATVPWTTDRFLRMLLPEGASTAWRDPSGSVAVFPLDLHEDWIGQPVEALQEAAGCRVAFVMRFGTGVLPDRRTVIQADDVVYAAALSGTVTDVAAAVAHAPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T7</accession>
    <name>A0A7W7T6T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-hydroxyarylamine O-acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.118</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.118" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046990">
        <property type="term" value="F:N-hydroxyarylamine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29323" checksum="E83415E05966FCBB" modified="2021-06-02" version="1">MWNGDQLDLDAYLDRVDYRPERDRTVTLRGLHRAHLRAIPFENGDIVAGVPIALDLPSIQDKLVGKRRGGYCYEHNLLFAAVLDRLGYQVTGLAARVVLGRPGDVPATHALLHVDRTWLVDVGFGGGGLLEPLPLVEDAFQAQGGWSFRLDLDEPTGVFTLQTYRENAWTDLYRFTKDPRTPADYTVLSHYLSTHPNSPFTARLLVQRTEDHALRRITGSEYSVTSPDDATTTRTLTPDELTAVLRTDFAGLELPTGVTRPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T771</accession>
    <name>A0A7W7T771_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14538" checksum="9477D0CC581F37A0" modified="2021-06-02" version="1">MASRRHPGQFDLFADAEDRPEPVETRRGRPSGFGGKPDLLVEVFDLVHDGRVGRLEHSGRVVELDGDGHCRHAHDDVAAMVESLLVQRYAVECGSAVLRHGAVRRDVLLVKLTRDGQNTRTRWSHLRGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T786</accession>
    <name>A0A7W7T786_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="350" mass="37192" checksum="9FEF974245D2DE3F" modified="2021-06-02" version="1">MIVPVRPIVVAGLGAVVAAAFACWLLDLPLGTDSAVYRSGALAVLDGVPLYGHLPATPSWSPDLPFAYPPVAALLFLPLAAVPTEFAWAGMAGLSVVCVGVVARLLPHGKRWWPLLPVMLEPVWRTVALGQVNLVLMTLVLVDVLRRSRWSGVLIGLAAAVKLTPLIFVGYLLIAGRRRDAARAVATFGVATGLGFLLLPGDSVRYWTSALLGANDAMSNAWWGNQSLNGVVLRLGGGTAVLAVLTLVCLGVAVYLTRKLVHDRPVEALLVMAFCGLLVSPISWSHHWVWVLPLGMLVARRPWWVVAVFSGAVLAVPLADNGYVLATLVAGVVLTVRVVRQSRRPIAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7C5</accession>
    <name>A0A7W7T7C5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="18897" checksum="80F94CF6C60E2AFA" modified="2021-06-02" version="1">MTPLGGVPLFGDLVTALDGVLVQVGLPPWFAALLELVVVVVAAYLLLWLVVRHVLPWLGRVLVGPLLRVVEGVRVLLLLPDLGATRLARRFGRMPPEAVYAYGAVVMGLVDGLGSVVRKALPVLSLARRTPRAVLFAALALGFVLWNAGTCGPLDEGCVEPVAQWTTSLTAWFERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H5</accession>
    <name>A0A7W7T7H5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16314" checksum="284567E242A9AAF3" modified="2021-06-02" version="1">MRVYLASDHAGFELKAHLADHLAASGHDVVDVGPAVYDAEDDYPPFCIEAARRVVADEGSLGVVIGGSGNGEQIAANKVPGARAALAYSVEIARLAREHNNAQLIGLGARMHSTEEATAIVEAFLATPFSTEPRHARRIGLLTAYESSGEAPKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H6</accession>
    <name>A0A7W7T7H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26679" checksum="0E480701FCCDE330" modified="2021-06-02" version="1">MGTLVWLLLLVVAAGGLWYFATTRAAARRRELEDARAEARRWVERLGGQVMNLIGTDEASKQALADASERFTAAGGQMESARTLEQCRLVTRTAMEGLYYVRAARTAMGLDPGPELPDLSGQSRAGRVSEDRDVTVEGRGYAASPRPGARTPHYYPGGMVAGRPVPQGWYSEPWWKPALVAGAWGVGTFLLFDAMFSGMAGVSPDALDAAYADGFADGSADGGDFGGDAGGDVGGDVGGDFGGDFGGDFGGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U0</accession>
    <name>A0A7W7T7U0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (DUF885 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="540" mass="59611" checksum="B5D329C4402C3730" modified="2021-06-02" version="1">MTTARELADELLTVLFDFDPVMATLLGVPGWDDRLPDHSADTAAASRREALDIARRASEGDDDPVTRAVVAQQASGFAHRIDAALVEHTHAEGLNAPVVVLLATLPLTRPADDEGRRAYLARLAGLPRYLEVLAGRQRASDRLPVAHLVRAGVDRLDRHLAQDPDPLAQPLAETAFADECRRTLVPVRDAFARYRAFLHDEVLPRGRAEDRPGLCWLPEGGERYVGLVGTYTTTTHTPRELHEIGLALIADLDREYADIGARVFGPITAAEVRRRLLDDPTLRWTSAGQMLDLARRTIARAEAAAPEWFGVVPDAACAVEEVPEADAPTAPLAYYMDPALDGSRPGTYFVNTHHATERERLGAEATAFHEGVPGHHFQIALAQRLTDLPLLRRFASVEAYHEGWALYTERLADEMGLYSDDVARLGMLAADSLRAARLVVDTGLHALGWSRQRAVEYLRDNAVMPDVDIHSEVDRYIENPAQALSYMVGRLEFQRLRGEAERRLGDRFDIRAFHDLVLGGGPLPMAVLADVVDEWCGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U3</accession>
    <name>A0A7W7T7U3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin Q/BCP</fullName>
            <ecNumber evidence="5">1.11.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16600" checksum="8789E0007A9743E2" modified="2021-06-02" version="1">MTNRLAPGDPAPAFTLPNSEGKPVSLADYRGRSVVVYFYPAAATPGCTKQACDFRDNLAVLAEAGYDVLGVSPDKPEKLAKFVAAEGLTFPLLSDVDKTVLTEWGAFGEKQNYGRTVQGVIRSTFLVGPEGEIVKALYNVRATGHVAKLIRELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D1</accession>
    <name>A0A7W7T8D1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AraC family transcriptional regulator of adaptative response / DNA-3-methyladenine glycosylase II</fullName>
            <ecNumber evidence="10">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052822">
        <property type="term" value="F:DNA-3-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052821">
        <property type="term" value="F:DNA-7-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="45467" checksum="498F1CE6FB873FCB" modified="2021-06-02" version="1">MLVDDERAYRAVAARDARFDGCFILAVRTTRIYCRPSCPAVTPKRRNAEFYPTAAAAQSAGYRACRRCLPDAVPGSPEWNLRADLAARAMRLISDGVVEREGVSGLASRLGYSERHLTRVLTAELGAGPLALARAHRAHSARLLIETTDLSFADVAFAAGFASVRQFNDTIRAVFASTPSAMRARRCAVGAPGRIVLRLPYRPPFDFAGLLEVFAVEAIPGVEHVTWSSYARSLRLPHGEGTVLLEPSDGHVRCSLRLTDLRDLGSAVSRVRRLLDLDADPQAVDSFLSADPALRPSVLARPGVRLPGSVDGAETLLRLLGHRRAGEPLRVPDGEVTHLYPEPAAVDSPVARALADGGLVVDVGCDQAELEARLTAFPGVGADIARQVVVRVLGAPDVPSTTDNAAWRPWRSYAALHSRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I1</accession>
    <name>A0A7W7T8I1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme PQQ synthesis protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PqqA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011725">
        <property type="entry name" value="PQQ_synth_PqqA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08042">
        <property type="entry name" value="PqqA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02107">
        <property type="entry name" value="PQQ_syn_pqqA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="38" mass="4263" checksum="1E114A67B878280C" modified="2021-06-02" version="1">MSAQEPKTAPAEQRPTWVKPDFRDVDTPMEITAYAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C7</accession>
    <name>A0A7W7T9C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="14452" checksum="F1160A8A03EF6241" modified="2021-06-02" version="1">MTIPQWVEPCLKTYEEDKMTIPKYPMEKPGSMVEVREVMKVLAVACSNRGYVVVLTTGELNRESGDDRMVGIPEQDAAILRKLIGAGLVIVVPAFRVMRSGPVVTSAAPVVISEHGWELLRQWEDLMGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9E1</accession>
    <name>A0A7W7T9E1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="39812" checksum="10C81146E05BA36C" modified="2021-06-02" version="1">MNASPYLAVLRTPRLPSMLALMLVARVPATAAGMTITMHVLLGLNRGYGEAGLVGALSTAGIGLGAPLLGRLVDRRGLRTMLLVTTLGETAFWFISPELPYPALVVAAFVGGLLVIPMMSLGRQVLTALAGPDLRRPALALDSMAVELAFMAGPACGVFLTTHWSSRTAMWAIGGSLAVLAVLLYAVNPPVRGEDEPAAGTPSGRRWAWIDGRVLGTLLTASAATFTMSGFEVSLVASMRGLGLTDWTGALIIVSCLASLVGGFVYGGLRSAPPAWVLMAGLGALTVPLGLVGDMPWVLALALVPASALCAPAIAATGEAITTLAPVEVRGEAMGLQGSAFTLGAALGQPAAGFAIDHTGPAWGYAVAGSGGVVIALLGALLSRRQPTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J9</accession>
    <name>A0A7W7T9J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16977" checksum="C78E3679AAA89729" modified="2021-06-02" version="1">MDGPSGAGKTTFAATLGGTVVPTDHFATWDNPVDWWPELVEGVLEPLTAGHAAHYRRVVWTDGTPSPGPWLTLPPCDLLVIEGVSSGRRAATPWLSELIWIEGPDEQTRLERAVARDGEYCRPDLKRWQTFERKWFTEDATRSRATKIIHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9S1</accession>
    <name>A0A7W7T9S1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="419" mass="44402" checksum="84B70E9F96435947" modified="2021-06-02" version="1">MDAQAVLGLAPDGKVAGAATKLAGSSGWHGLGRSDLALWGLCKGSGAKPYAVCVDLGDRATKCSCPSRKFPCKHALALQLRDLGTPLEEGEPPDWAREWLDRRKAAAPVDDSPEAVERRARAKERTAAKREASVRVGVAGLTDWLADVAGAGIAALPGREAAWWQGVTARMVDAKAQGLAAAVENVRAAVAAGGSRWAHDAADRLGGLHLLTRLAGTDSAVVRRRLGYSVTEEEVRAAPGMTDRWISLLRRETDEGRFRTLRQWAWGREHGWVLAERHARGDARPVPVLPHGVELHAVLHRYPGSSRVALGEVITEQPLGPVPASASWVEALAGLEPALLADPWERVHPVSCAGVRLSADATHAVDAEGRALRIHAGLALDQVVAITGGTPFDLWALWDGETLRPGAVALAGDAPEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W3</accession>
    <name>A0A7W7T9W3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31376" checksum="C1AA63F4976133A2" modified="2021-06-02" version="1">MGWLSGLWFAATFVPLLWRARYPVAVIAVTGASTWLFYVTGHNGPLVLAPALAVLSLRRTRSRERRARQAEEERLRIAREVHDVVAHSLAMINVQAGVAAHVADRRPEEAVKALRAIKAASGHALDDLRATLGVLRDDGTMPVPSLARLSELVDPVPDVTVVGDPGDLPAPVDAAAYRVVQESLTNAVRHAPGVAVTVTFHRTPTAVEITVDNGPGTGEGTPGAGAGLRGMRERVEALGGRVEAGAHEGGFRVHAALPLEGVGDQSRTRGRPGARAGRVPAAARHGGRFRGRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y0</accession>
    <name>A0A7W7T9Y0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="PTHR43762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="45741" checksum="783295CFB3C206D0" modified="2021-06-02" version="1">MWTNWARTASATPHRVARPTSIDGIAAAVTSAPAVRPRGSGHSFTDIAVAPGVALDLDRWTGVVEVSGTLATVRSGTTLRTLGAALDTVGLALENLGDIDAQTVAGALSTGTHGTGARFGGLATQVVALELVLADGSHVRCSAAENPALFDAARIGLGALGVITTVTLRCVPAFTLHAREYPDRLDAVLDGFDHLTATEDHVEFHWFPHGDRVLVKRNNRVDGPPAPLSAARRFYEYEVVENGAFGLICGIARHLPRTTRPLGRLCGVLLSGRDYRDVSHRVFVTPRRVRFVESEYAVPRESLHDVLRELRTAVDRLDHGVIVPVEVRVAAGDDIWLSTAYGRDTAYVAVHQALGMPYRRYFEAFAKIAGAVGGRPHWGKLHGLTAPDLRERYPRFDDFRRVRAEVDPGGRFGNAYLDRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA43</accession>
    <name>A0A7W7TA43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="21279" checksum="5BCD652B7EFCD93C" modified="2021-06-02" version="1">MLEFAILGLLHEAPMHGYELRKRLHELLGAFRAFSYGSLYPTLRRLQRDGLIVEEVPDDNRSWGRRARKVYKLTAEGKERFADLLANAGPQTWDDDSFGVHLAFFSRTPAEIRMRILEGRRRRVEERREGLRSSLSATSERIDRYTRELHRMGLDSTEREVRWLNELIAHEQAEQRERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA63</accession>
    <name>A0A7W7TA63_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">F4559_006655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="102"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4969296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="33440" checksum="A35745AE05D0F3DF" modified="2021-06-02" version="1">MTNRWVAVLSGGLSHEREVSLRSGRRLSAALRSTGLVVEEWDADAQLLTRLKEHRPDAVVVALHGGEGENGAVQAVLELAGVPFVGTDSHACRRAYDKPTAKSELARVGLATPEWAVLPHATFRELGAKPVLDALVAKLGLPLMLKPDQGGSALGAQVVRDAADLPAAMVGCLAYGDTVLAERYVEGVEVAVTVVDGPDGPYALPAVEIVPENGVYDYTARYTAGLTVFHAPARLDEKAARAVGELAVNAHKLLGLRDVSRTDAIVSADGTVWFLEVTVSPGLTETSLVPMAAEAAGQSLGEIYAGLVERAVTRSAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAE3</accession>
    <name>A0A7W7TAE3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">F4559_006852</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="299"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4969493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="430" mass="46069" checksum="E799477C64D95213" modified="2021-06-02" version="1">MPAVVLIGAQWGDEGKGKATDLLGERVQWVVRYQGGNNAGHTVVLPDGQKFALHLIPSGILTPGVTSVIGNGVVVDPAVLLDELAGLEQQGVDTSTLLISADAHLIMPYHVAIDKVTERYLGKAKIGTTGRGIGPCYQDKIARVGVRAQDLLDEKILRQKVEAALDFKNQVLVKVYNRKALDANQIVDGVLEHGAKFASRIADTRLLLNQALERGETVLLEGSQGTLLDVDHGTYPFVTSSNPTSGGASAGSGIGPTRITTVIGILKAYTTRVGSGPFPTELNDDMGEHLRKTGGEFGVTTGRSRRTGWFDAVIARYAARVNGITDFFLTKLDVLSGLEKVPVCVGYTVDGQRVDDMPMTQTDVHHAVPVYEELPGWFEDISGCRTFEELPANARAYVEYLESISGARVSAIGVGPGRDQTIVRHDMLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG6</accession>
    <name>A0A7W7TAG6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031355163" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="102"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="26866" checksum="C6D437500CF0424C" modified="2021-06-02" version="1">MVKRIVAAVAVVTVAMGLTSCVKFVQETLRDEHTIKDQIATVRVQNGSGDAFVRSSDQATEVRIVRTFNFSKSMDAPPKDTYRTEGSTLVLEGCGNQCSVDYEVVVPAKDVKIVGENSSGDVRFEDLASVEIDLGSGNATLKGISGAVRLENNSGDVNATDVGGDFTGQLGSGNATLTGMRGAVSVDNNSGDLIVKMAQVKPVRAEAGSGNVDVRVPAGAYKVEAGSGSGNTDVSVKSDPAATVDLVLRANSGDVTLHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TC32</accession>
    <name>A0A7W7TC32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TQXA domain-containing protein/LPXTG-motif cell wall-anchored protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030954410" evidence="6">
        <location>
            <begin position="31"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="42879" checksum="9965E7A1E3111C20" modified="2021-06-02" version="1">MAHRLTLKRVGAAVLGASLVLMSGALPALADPVKIVPHPPANEQGMGVHLVGKKDAVNTELIGVKVTSDGKSQTLKTYCVELPTPLEDTTPLHEVPWDQHPNPDTKFKQNAAKVNWVLTHGYPRLTVDEARTKFGLPDLKSSSLIAATQAAVWHYSDGAELTKPDATAEPADVDAHVVKVYDYLTGDDNTGEAEPKPTLDIKPDETVHGKAGERIGPFTVTTTAKQIVLKADLPAGVKLVDKDGKELPYVKAGDAAAKAAPADVTVTDVYIQVEAGTKAGEAEFTVEATATLSQGRLFVSEDRNKKTQSLIVVTPVDVDVRDTAKADWTEVVTTTTTAPSTTPAPTTTQAPSTTPAPTTTTTQAPTTGGQDDDLASTGASIFVPLLIGLGLLGAGAAALIIVRRRKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT85</accession>
    <name>A0A7W7WT85_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11714" checksum="E2608C6656D95398" modified="2021-06-02" version="1">MWLCRESDDLVARRACLTAVVRTVLDLGVVRLSLESAQHQDARDRRTIAAVVGKAADFGYDHFRSSEEPLLWAADALAWCFGAGGEWRRRVEPFVDEVFHLDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTF5</accession>
    <name>A0A7W7WTF5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase / fumarate reductase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000408</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15565" checksum="A6FB82D326682B63" modified="2021-06-02" version="1">MAGTTATERAGTSRGGGTLYRGDLGMWSWVAHRITGVLTFFFLFAHVLDTALVRVSPDAYDKVIETYKNPVVNLFEVGLVGAVLYHALNGIRVMLVDFWSKGPKYQRPMLWVILAIWVAVMIPGTYFMMVRTVTDLFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTK0</accession>
    <name>A0A7W7WTK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000151</name>
        <name evidence="4" type="ORF">F4559_001236</name>
        <name evidence="5" type="ORF">F4559_003619</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15700" checksum="7116E20B21352FC5" modified="2021-06-02" version="1">MLTPGQAGDSPQFRTVLDRIRVPGPVGRPRTRPDAVAADKAYSSKANRAYLRRRRITAVIPEKTDQRANRRNKGSAGGRPVSFDPVRYRRRNTVERLFQKIKTWRGLATRYDKTPQSYEAGLHLRGAIVWLKTLTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU24</accession>
    <name>A0A7W7WU24_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="33631" checksum="850A31C366C21A4E" modified="2021-06-02" version="1">MTFFPTPDEFYRDPLYLGLSAQAIALWTVAGSWSADRLTDGFVPTAALALFPTIDPAAADELVARGIWKRARGGHQYVDWPRTCSREYVLAKREKERDKKRGQRAANPGAGSRTPSSKPVVSPGDTRGDTPGTHVGSPSGSPRPSSKPVQPVQPNKEQPPSGVVAPTRPRASAGTYIPEDFTATDEMIAWARKETPLVGAAETDQFRDYWLAACGPSAKKRNWLAAWRKWMREAQAKAEAAPVRPHPLVRQRQGLGRVPTTDTGTVTGSRRMDKVLAALEPDDPFLADYLDEPPTNDHLLVIEGGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU76</accession>
    <name>A0A7W7WU76_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="10" type="ORF">F4559_001293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="519" mass="55099" checksum="85DFD09DC9B63CF7" modified="2021-06-02" version="1">MFNTLSDRLTSVLQNLRGKGRLSEADVDATAREIRVALLEADVALPVVRAFIAKVKDRAKGTEVSQALNPAQQVVKIVNEELVAILGGETRRLDLAKNPPTVIMLAGLQGAGKTTLAGKLARWLKSQGHTPMLVACDLQRPNAVTQLQVVGERAGVPVFAPEPGNGVGDPVDVSRRGIDEAKRAQHDIVIVDTAGRLGVDEEMMRQAIDIRAAVQPDEVLFVVDAMIGQDAVNTATAFRDGVGFTGVVLTKLDGDARGGAALSVRELTGQPIMFASNGEKLEDFDVFHPDRMASRILGMGDVLTLIEQAEQAFDAEQAEATAQKLGSGQLTLEDFLEQMLAIRKMGPIANLLGMLPGAGQMKDQLAMLDEKHLDRVQAIIRGMTPAERDDPKIINASRRLRIANGSGVKVSDVNELVNRFFEARKMMSQMAGRFGLPGGRSSNRKGKGKKGKKGKGGRGPTPPKMRGGFPGMPGMLPGAMPGGGMPGGTPGGMPELPPGLGGLDQLPPGFDPSKLKFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF2</accession>
    <name>A0A7W7WUF2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbonic anhydrase</fullName>
            <ecNumber evidence="4">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_001548</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="13">
        <location>
            <begin position="25"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4964189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="730" mass="76037" checksum="E99FF150F48A7E8B" modified="2021-06-02" version="1">MNRPRPNKSHAGEHTTPGPPRLWRTDLPASLVVFLIAVPLSLGFAAASGAPLIAGLVSAAVGGIVAGALGGAPLQVSGPAAGMVLIIGSVIATYGWPATAMITVGAGLVQVLAGLSRVGRAALALPPAVVHGLLAGIGVTIAVGQLVVLVGADAAPSTTTNLSLLASATPVPAELLVGTTAVIVLLLWPRLPRVGSVPAPLPAVLAATLVGTTLPVARVDLPGNPLHDLALPRLPHGSVFGIAVAVVTVAAVTAVESLLSAVALDKLHDGPRADLDRELVAQGVANAVSGACGGLPLSGGIARSSAGIAAGARGRATPILHGVWIAVFVIALGGLLESIPLSALAGVLLVIGVKLVSPRRIRTLWRHGEFAGYAVTAIGVTVFGLVSGVLLGVGVAVLRSLYRLTHSSIKVEDDLDGPRVVIRGALVFLAVGRLVRVLRDVPLGLRVTLELHIDFLDHGAFEAIDEWRTGYERLGGHVDVDEVHDTWFSKARGGTPALRRTPPSPPPRWFAPWSHWQHAHTPVTLPRQRNGTDPLIRGMHEFERTTAPLVRPFLTELAERGQRPKQLFITCADSRVVPNLITTSGPGDLFCVRNIGNLVPVDGDDSVAAAVEYAVEVLAVDTIAVCGHSDCGAMKALVDGSVTAKSKLWSWLRAAESSLIRFHLPHGSDLPPVERLAVANVAQQLDNLLSYPCVREAVDANALRLVGMYFDIAAARVYLVDRDRLTPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF5</accession>
    <name>A0A7W7WUF5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 11">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_001500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="12">
        <location>
            <begin position="15"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="13">
        <location>
            <begin position="472"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4964141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="542" mass="54937" checksum="BC2D7C767C8C0D0B" modified="2021-06-02" version="1">MNTPPSGPLWEARADLVVVGTGVAGLTAALRARELGLRVLVVTKAGRGDGNTRWAQGGVAVVLADEHEDGDSVEAHVADTLVAGAGLCDEAAVRAIIADGPAAVARLRARGAVFDTGADGFLARTREGGHSAFRVVHAGGDATGAEVERALLAAAVDGRVPVLEDHVAVDAVRTPLGHVCGLLVLDGNGVPGVLTAPAVLLASGGLGQLYQATSNPEVATGDGLALALRAGAVAADVEFVQFHPTVLYTGRGARGRCPLVTEAVRGEGAVLVDATGARVMRGVHPLEDLAPRDVVAAAITRHMAAGPGGVDDHVFLDATGIADFARRFPTVYAACVTAAVDPSVDPIPVAPAAHFACGGVVADVDGRTGVPGLYAAGEVARTGLHGANRLASNSLLEGLVVGTRAAEAVAADLALGVVVKSVGNPGLPTAPVADRDSLQRVMSRYAAIGRDAEGLAVVGSVLDLSTVDTVLDSKRAVEDAALTLAARALIAAAAERDESRGCHVRTDFTTRDDVRWQRSQLLRLNPSGQPVLADPVAARGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG1</accession>
    <name>A0A7W7WUG1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="9046" checksum="503421532566430D" modified="2021-06-02" version="1">MTAPDPETTAARDLATAWCTLPGWTRAHALIEIGSMGAVALYSTGCERDYRPPDPEVDEPIVAPDDMPRCKRCLRRSEERAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ4</accession>
    <name>A0A7W7WUJ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding Lrp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8038" checksum="8272ADC727F9EC6A" modified="2021-06-02" version="1">MVHAYILIQTEVGKAAAVAGQISGIPGVATAEDVTGPYDVIVRAEAETVDQLGQLVVARIQNVEGITRTLTCPVVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ7</accession>
    <name>A0A7W7WUJ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="20570" checksum="D0997A561B005483" modified="2021-06-02" version="1">MHIAWTSFLLALVVITIVPGPDFVLVTSSAVRGVRMGVLAACGVVTGLLVHAVLATVGLSALVVAFPAALVAVKAIGAAYLAYMGFVALRSARNSVPVADSATGTGSVFVRGLLCDLLNPKVMLTFLSLIPQAMDPTAPPLPQAVLLSAVTVGVFAVFWTIVVPLASRLAALLNRPRVRPVFERVCGTALIGMAASVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN9</accession>
    <name>A0A7W7WUN9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA pseudouridine32 synthase/23S rRNA pseudouridine746 synthase</fullName>
            <ecNumber evidence="2">5.4.99.28</ecNumber>
            <ecNumber evidence="2">5.4.99.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.28" evidence="2"/>
    <dbReference type="EC" id="5.4.99.29" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="101"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="34136" checksum="E09F8C71E2692F69" modified="2021-06-02" version="1">MRRKQRPAALAQRHGLDPARLRLPDEGHWTTLRDHLVDRLPRVEPARIDELLAQGAIHDLHGPLAPDTPFAPGTSVWFHRDLPNEVPVPFDISVVHRDDAILVVDKPHFLATIPRGSHIVETALVRLRRDLDLPTLSPAHRLDRGTAGLVLFVVDPTLRGRYQNLFRDRGVHKEYEAIARYDPGLDLPRTVTSRIVKIKGVITAQEVPGEPNAETRIELVEHDGQWGRYRLLPTTGRTHQLRLHLSSLGIPIRDDDFYPVLTEKPLDDFTNPLRLLAKVLAFTDPVTGEHRRFTSGLRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV00</accession>
    <name>A0A7W7WV00_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent 2,4-dienoyl-CoA reductase/sulfur reductase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="325"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="46034" checksum="82CED4022685E562" modified="2021-06-02" version="1">MNEERIVVAGGGLAGLRAGERVRELGFRGELVIVGAERHLPYHRPALSKEAVLGELRARDLRLAAGRELDAVWRLGTAVTHLEPDRHVVGLPGGEELSYDGLVVATGVEPRHLAGAPRHDPRVHVLRTVDDALAIKRAIGATQGLVVVVGGGLIGCELASTVRALGRDVAIVSRSGMLLGNAVGRDIAETVTRAHRSHGVRLALGVDIRHWVRQRGGVGVHLSDGQVFFAAVVVIAVGASPATAWLRGSGLDVSDGVLCDPTCHVVGASDVVAAGDVARWPNLRFPGPPRRVEHWLNAVEMGRAAAENLLAGRSDARPFTPVPRFWTEQYGMRIQGSGLPATGDDTITLAASRKDHRTVTGFVKGGRLVGMVGLDAPTAMIRLAPELWRQNGVAAPARALPGHRPDPVGTPAHAPVVRARPVGRRLVRIGPRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE7</accession>
    <name>A0A7W7WVE7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="251"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="37049" checksum="478D8D814296CAB0" modified="2021-06-02" version="1">MNSTRIAAAVRLGSALGSGAAVEWEEVFGALRAAMPQMCAVQINGWDPVVRRFVVMAEDGYNRSSSQELAHELPRTRWGGQLFDSAVPLLMTDNMPHDFRDSPHYQERLRPAGFEDGLSAALKVGRRQVVGVLHMNAPVRYSFTEETREFVASVGAALARRVDPLHCPRFDAWFDEHWSASWLLPAVAPVSDRSPAPIAGDPALRALADSFAGLGVRTVPFLWPGREGWYRVRLLRVVDGPRSGVIVACTPFENHAGLTARELDIATGLVAGLSNQAIAESLVVSRRTVETYVERLLTKLDCQSRGEAAGVAARAGYVRPSPTGLGELSRLTRGLDPGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK8</accession>
    <name>A0A7W7WVK8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="8" type="ORF">F4559_001997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="34942" checksum="4EAB81C8E8521A7B" modified="2021-06-02" version="1">MTSSVKDELSRLAVAKTCCRRAEVASLLRFAGGLHIVGGRVVVEAELDLGSTARRLRREVHELYGHQSDVFTITSSGLRKGTRFVVRVVKDGEGLARQTGLLDPRGRPVRGLPAPVVSGGVCDAEAAWRGAFLAHGSLTEPGRSSSMEVTCPGPEAALALVGAARRMGIGSKQREVRGAERVVIRDGDAIGAMLTRLGAHDSVLAWEERRMRREVRATANRLANFDDANLRRSARAAVAAAARVRRALEILGAEAPDHLAAAGELRLAHRQASLEELGQLSDPQMTKDAVAGRIRRLLAMADKRAKELGMPDTESAVTADMLEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR9</accession>
    <name>A0A7W7WVR9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NBD/HSP70 family sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="400" mass="42772" checksum="19BA1D6685B60633" modified="2021-06-02" version="1">MIDARDLLVPASGARDANRKRMIIEIMVKADRQSRIARRSGLSQASVSTAVQELVDQGVLEHDRGRGRGGLVRLTPVRGVAVGVDISHEHVVVVARRVDQGHDHVTVQQRPDGANHGLSRLLPQIKTMLAEVVEETGQTLDDVVSAGLAVPRMIDPRTGRFATPVLLPWHEDDEPAEDIGRFLGLRVAVDNDANLGAMAEQIYGMDEPAETVVYVKATTGVGVGIMIGDLLYRGHRGMAGEIGHLTIDRDGDVCECGGRGCLDTIVGAAALVAEVRTSHRGSGTTDLPVTLRSVIEKAHARDAVCLRVLRDAGRALGFALAQLCNLVNPRLVVLGGELAGGRDLVLEPCGQELQRYALAGAVDPREGFVLRTSQLGHNTEAQGALILGLRSRQFDEGSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY6</accession>
    <name>A0A7W7WVY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="22858" checksum="EFAD62AF718CDCBD" modified="2021-06-02" version="1">MNPDPIRVLVADDQAIVREGLVLVLGLLPGIQVVATAADGREAVRRVAESTPDVVLMDLRMPVLDGVEATRLVLDAHPAAKVLVLTTYADEESVVAALRAGAHGYLTKDAHADTIADAIAAVLRGDTPFDPAVTRHLVTMATSGRQARLTDRETEVLRLIALGLSNAEIARQLYVTEATVKTHVNNLFAKTGVRDRAQAVIYAYRHHLVVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVZ2</accession>
    <name>A0A7W7WVZ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031148115" evidence="6">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="21378" checksum="146921D2DEDBCAB8" modified="2021-06-02" version="1">MTTLTLLAFTAAAALIVVVPGPDQALLLQTSAAAGRPAAMRTACGILLGIVLWGIASVLGLSAVVAGSSTAYRVITVAGASYLIWLGVKALRSALSTAVATSGPHGGHRHRGFFRRGLLTNLLNPKIGLFYLSILPEFLPSATAPGLRDQVVLFSIYVAVSALWLLGFAFAAGSLHPTLNRPRVRRSLDSVLGLVLVGLGVTSLVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW46</accession>
    <name>A0A7W7WW46_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4132 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="1">
        <location>
            <begin position="27"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31169" checksum="788561FD4E045C17" modified="2021-06-02" version="1">MSWLDAASGYQVRLGENGRVQCRNGKGKTLSSVPASIKDDPQVVQLRQLAEWLSRHDEECRSAVDGWMVRSLPVPTAVLIEVWADEAWASALRDLVVTADGETGFLRDVDAERGLGVVTLDGETLRVKPETVDIPHPVLLADLEELREFGAELGVEQKVQQLFRQTFVKPDSFPKGRTSVADFSNGKFEQLNHATGRCRTLGYPVRGGDAVYAAFEGGRIVEARFWIGSDYPEGETWTGDLNWTLEDGTTVPLADVGPVAWSEGMRMAASIHAGRVVEEAKVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW95</accession>
    <name>A0A7W7WW95_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular small neutral protease</fullName>
            <ecNumber evidence="3">3.4.24.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Snapalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.</text>
            <dbReference type="EC" id="3.4.24.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.77" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000013">
        <property type="entry name" value="Peptidase_M7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02031">
        <property type="entry name" value="Peptidase_M7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00787">
        <property type="entry name" value="NEUTRALPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030574016" description="Extracellular small neutral protease" evidence="6">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="20617" checksum="8D8FF508EE3634C1" modified="2021-06-02" version="1">MQLRKVAGVAALAVGLMAPMAAVATAAPAAEANALVRTLYYDTSQAQEFVADWDKAAENWNKSVVNVKLAKKTAGSPTNIRVLADNGWPRAIPSTLGNGTVYMGRQAVQQGHYKPRITTHEIGHILGLPDRRTGLCTDLMSGSSAPATCKNDLPNAAEKAEVDRKFRGSLAAPAQAGFGASLTVKGTKNTECYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWC1</accession>
    <name>A0A7W7WWC1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025495">
        <property type="entry name" value="DUF4386"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14329">
        <property type="entry name" value="DUF4386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23009" checksum="F966D4EC39F849E7" modified="2021-06-02" version="1">MLLLVEGLLLFVPLVILGAAVDWPASLGEPAAAVLPRVAENETALRLGYVLYLAYSALFLPVALWATVTLAPDRQDSRPARLGLAFAALSALARCVGIVRWLTTMPDLAHGWQEGGNREAIEVQYDALNSFAGGVGELLGVSLFAAGWLLCLAGIADLPAWLRGFTVLTAAALALPLVELLGVDAGALISVGSATVQVWFLVAAVYVFRSARGSRRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG1</accession>
    <name>A0A7W7WWG1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="33" mass="3525" checksum="87BD357C3A7B9635" modified="2021-06-02" version="1">MRDGDTTGVVPVHGFEGWPSAGDDAMPWRGPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG8</accession>
    <name>A0A7W7WWG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13521" checksum="F1A6FB10D26B764C" modified="2021-06-02" version="1">MHVHLVFVTKYRRDVLTGEHPDFLREVFGRICADFGAVLTECNGEDDQVHLLVEYPPQVAVSKLVNSLKGVSSRRLRQNYRVRTHRDHLWSPSYFAASCGGAPLSIIKQYVENQRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT3</accession>
    <name>A0A7W7WWT3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11515" checksum="F316337A6628B219" modified="2021-06-02" version="1">MVPHLRRCPRGTGGQDGQRQDVGQRDRSGVRERMARVHDDHPAFPVQQVPRVPSGVQGQPGERDDHLVAHQRGAGAGDRQFRPEVRADVRERGGEGRRDRLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU9</accession>
    <name>A0A7W7WWU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031795">
        <property type="entry name" value="Zf-HC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16827">
        <property type="entry name" value="zf-HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13412" checksum="16AF6BCC4F908734" modified="2021-06-02" version="1">MARRFRWLPHDGGRHAVPVGLAAGADGATLCGLAVTAPSTSPPRHPHGCWPTCTACDTAWRRAEGIPLPSERRRTGGPPEQARGTTAVVVVGRLPDGQVRSSVVAHVPGLLDAALDLHTVAQSEMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE2</accession>
    <name>A0A7W7WXE2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="98"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="38384" checksum="97995A5DE4707500" modified="2021-06-02" version="1">MLAADTPSALSDLDTYREGGFFFASPTGVLVAEDAGTPAPERLAPGSVLVGALPFRPDRPARLTVPALVRRGAALHTVALPASPTPGGRWLDQRTDATAYTDGVARALRHMADGDLNKVVLARALDLTAAEPIDVRQVLAALAARDPHGYTFATDLGGSTLIGTSPELLVRRTGTAVVSNPLAGSRPRSTDPEQDGRNATELLVSTKDQREHALVVQAIADGLAPFCRRLDVPSTPELLPTRTMWHLSTRVTGELRSGETTSLDLASALHPTPAVCGVPVEAARSLIGEVEPFDRGYYTGVVGWTDDRGDGEWVVAIRCGEVADRTLRLYAGAGVVPGSTPAAELAETSAKFRTFLGALGLKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW3</accession>
    <name>A0A7W7WXW3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative repeat protein (TIGR03943 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40047">
        <property type="entry name" value="PTHR40047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24667" checksum="15C9073C79F8269F" modified="2021-06-02" version="1">MRRETQNILLVLLGGALLKLALTDTYLRYVKESLRPWLIATGAIMVVLALVAIVRDIRREREHDHDHRSHSTWLLLLPVLAVFLISPPALGADTVTGKGNTAPKAGAGFEALPDETVVPLTITDFVMRTAWDDSGSLDDRTVRLTGFVARQGTNVYIARLTISCCAADARPVKALLAGQDFATLPTDQWIEATGRVVPGSATQASAFVPTLTVTTITTIPAPPEPYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY5</accession>
    <name>A0A7W7WXY5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="7832" checksum="08120028FB1AE3AF" modified="2021-06-02" version="1">MSDWIVEVDRSRCLGTGMCTNVAPDRFTRQEDGSAVPVDGRVEPGNGVLDAAESCPVEAILVRDSDGSVLAPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY20</accession>
    <name>A0A7W7WY20_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="329" mass="36760" checksum="F3742E9C7E09606D" modified="2021-06-02" version="1">MRETTVLPGTPCDAPREGELPMHRLEVALPNSMPFSIGTFDAIGPLSHAPFPHRHTFHEIVYVTGGSGAHVVDFARWDLKPPHLCVISPGQVHHWDDVRELEGYVVLFTDDFLIDHPADREVLRRLSERPWLTLDDDTRDRTSSLMRELEEEYRESAEGVESVLRSLLHVLVLRAARLPETPSATMPARPGAVADEFARLLGRADLDLWSVRAYAEHIGVTPGYLTEAVKAATGRTPSQLVREARAHEAKRLLVKTDLTVRQVGNRVGFVDPAYFCRFFRRETGVSPGDFRRAGAGRPVVPARVDVHSYYGPGDSPRPAAPVHRPRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE8</accession>
    <name>A0A7W7WYE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14445" checksum="A4709D08CD88BB1D" modified="2021-06-02" version="1">MADPARETTFLPLTMSAAGDAGDDGARTVRHRAEVADRAAADCWLSLVAGCTSGRETLIDSLHDLSEATSGYAGPQWWLSHGSVHRRRVAAAEHRIDDAVREGDGAEFAEAFIGYDQAVATVLVHVRNRLGNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYP6</accession>
    <name>A0A7W7WYP6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">F4559_005282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="8"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21778" checksum="EAC030DB2F9BCB0B" modified="2021-06-02" version="1">MSNRRVGVMGGTFDPVHHGHLVAASEVQARFGLDEVVFVPTGRPWQKTGRDVSPAEDRYLMTVIATASNPRFSVSRVDIDRDGPTYTYDTLSDLRTRHPDADLFFITGADALEQILSWRRADEMFDLAHFIGVTRPGYELDDRHLPEGSVSLVEVPAMAISSTGVRSRTAAGLPVWYLVPDGVVQYISKNGLYSVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ2</accession>
    <name>A0A7W7WYQ2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005297</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="11"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="27890" checksum="C6C76336C3719329" modified="2021-06-02" version="1">MAVVLGPVRAVLVCVEHRLTWYRRNWRASVVSNFLQPVLFLLALGLGFGSQVRPGPATGGLPYVEFLAPALLVVTALQATIQESTYAVLSALKWEKRYVGLVATPVTPAQVLYGHLVWIAAQSALATTAFLVVAALLGAVTSPLAVLAVPAAVLAGMAFSAPTVAFSVTREQPAGFGALHRFLVMPMVLFGGTYFPLDQLPDWLHPVVWLTPVWHGVELCRGLALGGLSPLAALGHVAYLAALVVLGTVPARRFFHRRLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ4</accession>
    <name>A0A7W7WYQ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031390817" evidence="1">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="16625" checksum="A409060F08340E11" modified="2021-06-02" version="1">MTRKIAALSCLLVLGACTSTPEPPSPAPATSATRPNGIGCDKAPADVVGPALSLNLAHTRETIEGTAVLCSYEGGGSTTSVRIETASGPEAFARTKLDYEDKGQDPEPVAGIGDEAYRATLGSGEVVQHTVVGRKGKTEIQVTSAASVESASRLLVRLLEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX6</accession>
    <name>A0A7W7WYX6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="120" mass="13331" checksum="B72C9DDBF0911C1C" modified="2021-06-02" version="1">MADRISLRGLRVRGRHGVFEHEKRDGQDFLVDITAWLDLSRAAATDDLRDTLHYGELAQRAAAIIGGEPYDLIETVAVKIAEEVLTDLRVRGTEVTVHKPSAPIPLTFADVSVTVRRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ98</accession>
    <name>A0A7W7WZ98_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="488" mass="51683" checksum="42B6FDC5962F63DD" modified="2021-06-02" version="1">MNTPLRRVGIAMMAMFLLLLANATYVQVIKADDYRKDPLNRRVLLDQYSRERGRIIAADDTPIAAVEKTTDRLRFLRTYADGPAFAPVTGYFSTTYGTGGLEHAEDDLLNGSDDRLFARRVSDLITGRDPKGGSIQLTIDPKLQKAAFDGLAGVTGSVVAIRPSTGEILAMTSTPSYDPNRLASHDPAVQEEAWEELNAPDSGEPMLNRSVDAIYPPGSTFKLVVASAALADGATKDTQVDGRPTIKPPGTDVPLPNFNDSICGNGVTATLQEALAKSCNTAFATLANDLGKDKLNKQAAKFGFDDKDLEIPLPVATSTLGPMADTPAIYQTGIGQRDVRVTPLLNCMVAATIANRGTRMAPQLVKKIIAPDLSIVDENKPDEVDEALEPEQADTLRDMMVESEKNTAGGGKLNGVTIASKTGTAEHGTNARATKPHAWYVAFAPAEKPEIAVAVLVENGGDAGLQATGGKVAAPIGRAVIGAFLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZD2</accession>
    <name>A0A7W7WZD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg-chelatase subunit ChlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="209"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="42252" checksum="DFB0B4E4F5F42B7D" modified="2021-06-02" version="1">MSTDETERLRRWRLLLGADAGDLSTLGTDDARRDSALTGLYGGGPVEGGGRKRGAGLSGSAPVLHRWLGDIRTYFPTSVVQVMQRDAVDRLGLRQLLLEPELLAGAEPDVNLVGTLLSLSSAIPARTRETARAVVRKVVEEIERRLAERLKAAVHGAVDRSRRTRRPRLSDVDWDATIRANLKHYQPDQGTVVVEQLRGHRRRSRTAALKDVILLVDQSGSMAESVVYSAVMGASLASLRSVDTKLVVFDTEVVDLTDELDDPVDLLFATQLGGGTDINRAVAYGQSLVRRPSDTVLVLISDLYEGGVADELRRRVRELVHSGVTVVVLLALSDGGTPAYDHELAAQLSDLGAPAFACTPDRFPDLLATALRKEDVAAWAEQNDMPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZF8</accession>
    <name>A0A7W7WZF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSer/pThr/pTyr-binding forkhead associated (FHA) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="16846" checksum="3D99494D40C23EB0" modified="2021-06-02" version="1">MPELVMQLTRAGFLILLWLFVLAALRVVRSDLYAASGLRVPTPRFGRRAKNNARGGAKAPRQLVVTHGALTGTRISLDGRPILIGRADDSTLVLDDDFASTRHARLSLRGTDWYVEDLGSTNGTYLDRAKVTAPLRVPLGSPIRIGKTVIELRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZH9</accession>
    <name>A0A7W7WZH9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20967" checksum="0372533AAB98B2F6" modified="2021-06-02" version="1">MTNPRDLRVSDAEREHVVGVLQKAIGRGLLTLDEFTERTDTALAAKTRGQLNAVLLDLPGVTHDSRAVSEPGSPEVFGERTELTSRMSSVRRKGEWVVPPRLVVRSHMGSTDLDFRDAKIPHAVVDVELDVTAGSVRIVVPEGSTVNAHGIEISAGSLKDRVGFGEGGRPHFVVHGAVRMGSVEIKRKKCSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXY3</accession>
    <name>A0A7W7SXY3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">F4559_000313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4962954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="539" mass="56065" checksum="E3C9A9B30041ADBB" modified="2021-06-02" version="1">MPKQISFDEDARRALERGVNKLADTVKVTLGPRGRHVVLDKKFGGPTVTNDGVTIAREIELDDAFENLGAQLAKSVATKTNDVAGDGTTTATVLAQAMVRVGLRNVAAGANPTALGRGIQSAADAVVEALKSKATPVKGRDNIAQVGTVSSRDESIGALLGEAIEKVGEDGVITVEESSTLATELVVTEGVQFDKGYISAHFATDLEAQETVFEDARILLHREKISALADLLPVLEKVAESGKPLVIIAEDVEGEALSTLVVNALRKTLRVVAVKAPYFGDRRKAFLDDLAVVTGGQVIAAEVGLKLSEAGLDVLGSARRIVVSKDNTTIVDGGGTKADVAGRAEQLRREIEATDSDWDREKLQERLAKLSGGIAVIKVGAATETELKERKHRIEDAVAATKAAVEEGIVPGGGSALVHAAKVLDGGLGLTGDEATGVAVLREALGSALFWIAANAGLEGAVVVNKVREGDWGFGLNAATLVYGDLLEAGIIDPVKVTRSAVANAASIARMVLTTESAVVEKKEEEAPAAAGHGHGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYB1</accession>
    <name>A0A7W7SYB1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23486" checksum="EC714B2B056F20B3" modified="2021-06-02" version="1">MASLSDVAHTLRTAADTLPVALLAHTTTGTSDPEVIATTDTFAEAYRRCTELLQTAQALHTHINTLADHLAPLPSKPPGRDVDRIRQEIPAGVRGARAQGRWLGPGTDSTVLRSGSADEWHRPAFEFLAAAFGRRAPELELAKHMEIKLAVRMRTEGRRRETLVIDRMVCGREPHNRRFQATCDKILKYVLPPGATLTVIEHDGTPVTYRGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP6</accession>
    <name>A0A7W7SYP6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23345" checksum="6049115BB84A5CA3" modified="2021-06-02" version="1">MASVTSVVVVDDHPAIVAGIEAWCAAADPPIEVLGSGPTPAAAWTEPGLGADVVVFDLQLTGSTPAYGDLRRLVTARRRVVVYTLREDRESVLTCLDLGAAAYLTKTEGPAHFVPAIRAAAQDLPYTPPVMARAFGTDDRPDRPRLTAREVDVLVNWFACESKEMVARKLNISVRTVNTYIDRARIRYADAGRPAHTKAALVARAIQDGLVRLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW2</accession>
    <name>A0A7W7SYW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="34397" checksum="CF18E602CFC1B2D1" modified="2021-06-02" version="1">MINVQLAFLTACLGDRSLDRIAHWAAGNGYDALEIAAWPGHSREHTANHLDVAHLDQRLVDETRALLALHGLGISAISYYDNNLHPDEAERHRVHEHLRACVRAAAELDVGCVGTFVGRDPGKTVSENQHIAARVLTPLTKYAAEHGVALAVENCPMPGWHPDGYPGNLAYSPELWDWMFELGFHLNYDPSHLVWLGIDPVTAISRYGDRIAHVQAKDTQVHHDRIDRYGVYGRATERVDPWDSGWWTYRVPGLGDIDWTRVVDALHVAGYSGAVAVEHEDPVWSGTEDRVLTGLRIARDTLRPMVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE3</accession>
    <name>A0A7W7SZE3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="31" mass="3423" checksum="47F8C4478988165A" modified="2021-06-02" version="1">MPLASSDVQQEYARADVDIRGRAEDTAERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T004</accession>
    <name>A0A7W7T004_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pre-crRNA processing endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010155">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029950">
        <property type="entry name" value="Cas_CT1134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01876">
        <property type="entry name" value="cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="24532" checksum="FFA27A69A6F996EF" modified="2021-06-02" version="1">MNRERPAASGPPPVVVQVWGDAALFTRPELKVERVSYPVMTPSAAVGVLESIYWKPQFSWRVEAIEVLSEIKQFTQRRNETTDLASLADAASGRRRIDTVANRVQRNAVCLRDVAYRIHAQVVLKPHADQTEAAYRAQFRRRVTRGSCFTQPYLGVREFSAYFGDPDDRKPFLDQDGELGLMLHSVDHGTTPPGFTWFEAKLVKGVLHVPEQGIDPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T042</accession>
    <name>A0A7W7T042_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ORF">F4559_001453</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="16285" checksum="7A5084AA2B0252C1" modified="2021-06-02" version="1">MFLGTHHPKLDDKGRLTLPAKFRDALAGGLMVTKGQDHCLYVFPRGEFEQMARKVADAPFTNEAVRAYQRYLFAGTDEQRPDGQGRVTIAPELRRYAGLTKECVVIGAINRLEIWDAQAWQRYLDEHEDSYAEAREEVLPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T049</accession>
    <name>A0A7W7T049_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell volume regulation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="395"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="493" mass="51521" checksum="31CCC66EFB078299" modified="2021-06-02" version="1">MGGVTAVLGIGAAVLLVSVIAVRMSVRLGLPSLLLYLGIGVVLGESVLGIQFEDADLTRSLGTVALVLILAEGGLTTRWSAVKPALGLGIALSTVSVAVSIGAVGVGLHYLLGLDWRTALLWGAVLSSTDAAAVFSVLRGVGVGKRLIGALELESGLNDAPVYIAVVLLASPDPVTWTAPALMVYELVVGGVIGVALGLLAAVGLRRAALPATGLYPLATVAVCLLAYTVGDLAHASGFLAVYVAALVLGNARLPHRSDTLSFAEGLGWLSQIGLFVLLGLYASPARVLDVLWPALVSGAVLVLVARPLSVLCAALPFRVPWREQVFLSWSGLRGAVPIVFALIPLIQDVPGAQRLVDVVFVLVVVLTLVQGSTLPRLAKWLGLVRSGEAWEMEVDSAALDELGAELLQIRVREGSKLHGVYLSELRLPVGAAVSLVVRADAGFTPQPTTRLQEHDQLLVVCTEAVRIAAERRIRAVDRAGRFARWKGDEGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T069</accession>
    <name>A0A7W7T069_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">F4559_000941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="152"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="382"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4963582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="548" mass="58736" checksum="0DF11C9D09B15C3C" modified="2021-06-02" version="1">MAELTISSDEIRSAIEKYVSTYSPEVSREEVGVVAETYDGIAIVEGLPGTMTNEILEFPGGVLGVALNLEVRTIGAVILGDFDKIEEGQEVKRTGRVLSVPVGDGFLGRVVNPLGQPIDGLGDVVADDVRALELQAATVLQRQPVGEPMQTGIKSIDAMTPIGRGQRQLIIGDRKTGKTAVCIDTIINQKKAWESGDPTQQVRCVYVAVGQKGSTIAGVKAALEEAGALEYTTIVAAPASDSAGFKWLAPYTGSAIGQHWMYQGKHVLIVFDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELGGGSMTGLPIIETKANDVSAYIPTNVISITDGQCFLESDLFNAGVRPAVNVGISVSRVGGAAQIKAMKQVSGSLRLDLSQFRELEAFSAFASDLDAASRAQLDRGARLVELLKQGQYSPFPVEEQVVSIFIGTQGHLDSVPVGDIRRFETEFLDHLRRNHTAILSGIRETKQLSDDARNGLVSAVDDFKQQFTASGGATKVNEAAATALGADEVGHESVKVNRPDPTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C4</accession>
    <name>A0A7W7T0C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046036">
        <property type="entry name" value="DUF5994"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19457">
        <property type="entry name" value="DUF5994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="17969" checksum="A196521E148527E7" modified="2021-06-02" version="1">MKPAGSALKPVAGGWWPWSDDPAAEFPALIAALGAWVGPVNRVSYHLDTWGAVARKAPVDGRMVRFEGFRSIDPHTVVAIGSDRRRVSLLVVPPATPAGMARAVLRSVADRDSTASVADILAANGVLPATHHLSPVIVPRPRPAEPAEEPPGNRRRPHQVTRTLPVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K1</accession>
    <name>A0A7W7T0K1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031030158" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="8409" checksum="D8A73293A8F2343F" modified="2021-06-02" version="1">MKPFLFLLLVLAVLALLALAVWAAHHRTGVRSRTLARYRAAVRDIEAKADLYRDIDSVLATEVRAILRTLREHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U4</accession>
    <name>A0A7W7T0U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="460" mass="50134" checksum="186779E6E4A97C0A" modified="2021-06-02" version="1">MAIDPAELEIALRVLAQVQDLPTEHPDVEAIRRATSSVYKDVRKRRKADRRAAELAADRAVTEATATGSPSRIDDETRGILLREPEPGAKAGTLLRARGCYTCKRRYVEVDAFYHQLCPECAALNRSKRDASADLSGRRALLTGGRAKIGMYIALRLLRDGAHTTITTRFPHDAVRRFASMPDSEDWLHRLRVVGIDLRDPSQVIRLADDVAQAGPLDILINNAAQTVRRSTNAYAPLVAAESAPLPAGPKPELVSFGHTLDRHPLALANTFTEGPDVTALALVAGSKEIDAGGLVPDEAAVNSWVQHVQEVDPVELLEVQLCNSTAPFILVSRLRAAMAAATARRKYVVNVSAMEGQFSRAYKGPGHPHTNMAKAALNMLTRTSAEEMLSDGILMTAVDTGWITDERPQPTKFRLAAEGFHAPLDLVDGAARVYDPIVRGEQGEDLYGCFLKDYAPSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T172</accession>
    <name>A0A7W7T172_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17497" checksum="16DAFD3723469404" modified="2021-06-02" version="1">MGVGRETRLSAWIERFAAHFAEEGIPLIGGRILGYLLVCRPSERTAAELSQELEASSGSISTNLKFLVAEGLVTKRTRRGRQAAQYRIDEKRWADLVQRKLDALVSVRELTESGMRLMSGDPERALRLRAVDDLYTWLATELPALWERRPSSTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M2</accession>
    <name>A0A7W7T1M2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">POT family proton-dependent oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17346">
        <property type="entry name" value="MFS_DtpA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="23"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="491" mass="51769" checksum="F47FE24BA0CF28E1" modified="2021-06-02" version="1">MSATSAVSAPQRGFFGHPRGLATLFFAEAWERFSYYGMKAILAYYLYRSTAEGALGLDKSYALSLVAIYGASVYMSGVAGGWLADRVLGGQRAVFHGGVLIMLGHVALALPIGVAGVYLGLVLIVLGTGLLKPNISTVVGGLYAADDPRRDAGFTIFYMGVNLGSFVAPLVCGALGEEIDWHLGFGAAAVGMALGLIVYRAGLRTLGDSAARPPYPLPEGERGRVLGRIAAIAVLAVGVVAVLVVTGALDGTGVINLISVLSIVLPVTYFTVMLRSGRTTDVERSRLTAYIPLFIAAALFWLLFEQSATVIAAFADERVDTTFLGLDFPPSFIQAINPVMIILCAPLFALLWVKLGKRQPSTPRKFAVSLLLIGVAYVLLMLASRGDAQTKVGFLWIIAMYLVMTCGELLLSPVGLSVTTKLAPRAFASQTMGLWFLASAAGQGIGAIVVRFYDPADPVPYFGVLGGVAIALGLVLVVTTPGIHRLMKGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q9</accession>
    <name>A0A7W7T1Q9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ca-activated chloride channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="90"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34039" checksum="068AE2F63D961D22" modified="2021-06-02" version="1">MSFSGFTAPWWFLLLVVVAALAAVYVVVQRVLRKRMLRFANLSMLERVAPRRQGWYRHVPVAFLMVAFLLLTVALAGPTAEQKVPRNRATVMLVVDVSLSMKATDVQPSRLEAAQVAAKSFADGLTPGINLGLISFAGSATVLVAPTTDRGAVTSNIDGLKLAQSTATGDAIVAALSAIDTFGKVVGGADGPPPARVVLMTDGKETVGTRRAFDAAEDAKKAGIPISTISFGTEDGVVEIEGRRQDVPVDDDSMREIAKLSGGEFFKAASAEELRRVYDTLGEQIGYEKKQADASRPWLILGTLVAMAAVAGALVLGQRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R5</accession>
    <name>A0A7W7T1R5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_002303</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="558" mass="61932" checksum="A52C39013D8AEC52" modified="2021-06-02" version="1">MTALEPEPVITHPGAARPGPKGSVLLGLLRTTDPKRIGLMYLTTSFGFFLVGGFMALLVRGELARPGLQFLSSEQYNQLFTMHGTIMLLLYATPILFGFANFVLPLQIGSPDVAFPRLNAFSYWLYLFGGLTVLLGFVAPGGAADFGWTAYTPLADFAHSPGVGADLWIMGLAVSGLGTILGGVNMVTTVVCLRGPGMTMFRMPIFTWNIFVTSILILLAFPILTAALMGLAADRHLGAHVFDPANGGVILWQHLFWFFGHPEVYIVALPFFGIVSEIFPVFSRKPLFGYRGLVYATFAIAALSVAVWAHHMFATGAVLLPFFSVMTFLIAVPTGIKFFNWIGTMWRGQLTFESPMLFSIGFLVTFLLGGLTGILLASPPLDFHVTDTYFVVAHFHYVLFGTIVFATYAGIYFWFPKMTGRMLSEPLGKLHFWTTFLGFHLTFLVQHWLGDEGMPRRYADYLPSDGFTVLNMVSTVGAFLLGLSVLPFVWNVFRSYRFGDPAPHDDPWGFGNSLEWATSSPPPRHNFTELPRIRSERPAFELHYPHMVDRLRSESGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R8</accession>
    <name>A0A7W7T1R8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisE</name>
        <name evidence="11" type="ORF">F4559_002322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9652" checksum="B7CAB5554110D7A4" modified="2021-06-02" version="1">MKTFDELFAELTDRARTRPAGSATVEALAAGVHAQGKKVLEEAGEVWIAAEHESDDRLAEEVSQLLYRVQVLMLGRGLTLEDVYKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T0</accession>
    <name>A0A7W7T1T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome assembly chaperone (PAC2) family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="32802" checksum="35D02C4DCB8AF513" modified="2021-06-02" version="1">MTDPDQAAQTPYDPEEPLTDPIMVAAFEGWNDAGDAASTAIEHLQLTWDAKPLAEIDPDDYYDFQVTRPTVRMVDGVTRRVEFPTTRLSVCRPPGASTDVVLVHGIEPNMRWRKFAGELLGHIDRLGITTVVTLGALLMDTPHTRPVPVTGTAYDAAAAAKFGLERSRYEGPTGIVGVFQDLCVQRGVPAISFWAAVPHYVSQPPSPKATLALLHRVEEVLDIEVPLGALPEQAEEWERTVSEMADEDEDVRNYVRALEERGDAEIQITESSGDDIAAEFERYLRRRGRGPGRGPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X7</accession>
    <name>A0A7W7T1X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="921"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1101"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1152"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2020" mass="216151" checksum="32201CA2BF062A35" modified="2021-06-02" version="1">MHAEPGSVPALPLQSGMVAAGLRDPEAGTDVVQCVLRWSAEYDRDAYLAAWRAAVDRHPVLRTRLRWRPDGGADQVLTPAADVPVGNDDTVSDVAAFLREDRRRGVDPVSGPALRVVALPGGVVVVTFHHAILDGRSLAMLLAEIDDDYAARLGGPAAVLPDRPDFADYARWHAARPTEADERFWRTELADLPDTGPLPLEHAASGPVRMATAALELSDEETTSVRALAATTGVTVNTVVLAAWSLLLAAHSGDDESAFAVTRAARHGTVEGAADMIGLLIATTPLRLPVDRDASVRTWLGAVRARSVAARDHQLGPVPEAGRVRSLVLFEHREINTVLADRATTPSDRHVEILRTPGYAVTLYAFAEPRLSLRLIHDAARFPDWAPDVLLGHVRDLLTGLARDPDRPVRAVGEPRGLDLAGWNDTAVPYPADATIPDLFAEQVRLRPDADAVLTPSGWLSYAELDRRANRLAHLLVARGARPDRPVGVALPRGADLVVTLLAVLKAGAAYLPLHPGNPAARDAAALRAAGASLVVADRPLDLPATVVLLSEVDDRLPDTAPDVRVHPDGLAYVNHTSGSTGRPKGVAVPHRGVVRLVSDPSFATFGPGRTFLHLSATAFDLTTLEVWGALLTGGRVVPAPEGPPDPAVLGPLLREHDVSVLWLTAGLFHQLDPALLTSVDHLLAGGDVLAPDAVRAALAARDGKPVVNGYGPTENTTFTTCHVMTSPDEVGATVPIGTPIQRTTAYVLDDDMRPAPVGVPGELYTGGAGLARGYQGEPALTAAKFVPDPFGAAGRRLYRTGDRARWRPDGVLEFLGRVDRQVKVRGFLVEPAEVEAVLRRHAGVSAVAVVPAGDDDTRHLVAYVVGSADGLREHAADHLPAYLCPARYVVLDALPLNSSGKVDRAALPAAGGTDVRTGTAPAPGTQTRLAGLWRMLLGVGRVHAEDDFFAVGGNSLLAVRLAFRVREEFGVEVPIAELHRARTLAACAEAVDRAGTTTTPPITRRDRSSYRVPTRAPADTRPGGTAQTRPATAHTRPPVPATAFGSAGGAAPTQAVAERTEAGPATTPTSRTADDSAPTDKKAGAGVIDLNADDLLPTAADKTGVTAPNPTAAGTATGARAGDPVPTRIPPTATASTEVASPGRTAPDAGQSPARSDTRSAAQIGHTDPTGHNRDMVGRLPDHLVSSGGDWAVWRWVELRGTGFGIEPLVALGSPAAARAADDVHAAREALGEARWAAFRALRAVEDAASGDERATLRRVGRLVRKGRFAEARGLVAGPADAVAALTLAARAAERVAEAEADYAGRFEHARVEVAGILRGVAGDARFREAVAWQNPRALVTAVDALRAASPAAARNVDYRRWEHTVVAYLQRYCAKNDTIGFFGPVGWAYVRDDAPAALTSVPGAGLVDRRTVYLENWAVQELAEVLTTDEVRPWAAPRRMPFVDVVGNVLHVPMTAPVVLDDAEARVLAACDGHRRAVDIAAGLSDVDDVFGVLDRLRKARRIAWTFEVAPSALVPERELRRQVERIDDPAVRDRIAATLDEVERGRGEVADAVGDPDRLVHAIGALQEKFTAITGTAAVRRPGLFYAGRTVVHEECRRDLDVTLSPALLDTLSPGLDLVLEAARWFTAAGAALYGKALREVYRRRVEATGDPTVRLADFWLWANDTIFRLDERLIARLVTALQRKWADALGAHDPDESRVHYEVDQVRDAVRKAFATARPGWRGAVQHSPDVLIAAKDAAAVRAGDYHWVLGEVHPGVNTMRAALFVSQHPDPVQLRDSMAADLGGPRVVLSTTREEGGTPQRLADALVLPRDLRIAFGHDACGPDLLGAVPVGECVIVEDGGRLVVRDRSGRVDHDLVELLNEQIMAQLVQHFRLLPAGAHTPRVSLDRLVVARETWRLKSADARFAFGPDEPTRFLDAQAWRIANAMPRYVFVKSPVEHKPFYVDLASPPSVELFAHAVRALDRERPDAPMTVGEMLPDPDHLWLTDAAGNRHTAEFRVVAVDRRGWRHFEEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X8</accession>
    <name>A0A7W7T1X8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031322394" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="9655" checksum="BDBE6A66BDA109F5" modified="2021-06-02" version="1">MMKSLIVAALLATLVPAPPASAAAYTVPRSATASGRGTSEANAEARARYNARVAVLAVGVDCVDWTSQLVVPTERTRQNEWTALVAVDALCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T268</accession>
    <name>A0A7W7T268_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsI/penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030787338" evidence="1">
        <location>
            <begin position="23"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="3">
        <location>
            <begin position="28"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="324"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="598" mass="61982" checksum="BB8CFEB804AD6856" modified="2021-06-02" version="1">MITRRLALVVAPLLVVAGCGLFSSRPGPDEVAGDFLTRLASGDTAGAAALTDDPGAAKDLLDKVRGALKPAGVRGSVEQVRSAGESSTAEATAALEWDFGHDHVWKYQTKFELRREEDDWRVHWVPSVVHPKLAAQQTLAATPVKASLAPVLDRDGAALLAPEQVVSVLLDPTQAGDVTAVATTLATALNPIDPAITRESIVDGAGKTAAGQVYQVAALRDADYQTVKPVIYELPGVRFTTQTSLLAPSRGFASQVLPAVRKFVEEDVEGRAGVRVFTANGSGDEVDSLYEQQPVTAQAVTTGLSRAVQTAAEDAVESSVGATMLVAIQPSTGEILAVAQNAAADEQGAIALTGRFAPGSTFKIVSAAHALAGGTAADVPVPCPGKTTIDGRRVVPNDHEFDKGTIPLHSAFAYSCNTTFAQLAVDYPADGLTKTADSFGLGVDFEIPALTTITGSVPAATDVVERAEDAFGQGKVLASPFGMALVAATVAKGSVPVPSLLRGRDVKADHTPTAPPPAVLEPLRVMMREVVEVGTAQLLNGLGDVRGKTGTAQYGDGTRSHGWFVGYRGDVAFATLVLDGNSSVPALEATGRFLRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2G6</accession>
    <name>A0A7W7T2G6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15758" checksum="4DF58541AD5AE55C" modified="2021-06-02" version="1">MRSLGRFLGGTVAIAAIAGLVLLGVRGCGAYLRAEAVTVIRYLHALGAGDTATVCDLVVEEARVKLLRLARADSCEEAAARLTAALAPEVRAELLRDDPGIYSIVVSGDRTEISLGAGPFDVHDFVLYERDGREKITDWGFEARRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M9</accession>
    <name>A0A7W7T2M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DMSO/TMAO reductase YedYZ heme-binding membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="110" mass="11512" checksum="7ABEC2AAC9046A5B" modified="2021-06-02" version="1">MDTGRQSRPWSTKDFVVEHRVPVGSVGGAVAAGVAVVYLVVVPAEGGTTAGLVGAILEYGHPACWLLLAVACALFASDRAKRTRRVLARSALAVYLVFILTLVLTQSGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W3</accession>
    <name>A0A7W7T2W3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26559" checksum="FA53CB126FD88C98" modified="2021-06-02" version="1">MKSWSLGPRELYLLCEYAERPWPAPLVEPELSVDLAGHRDDGRLAAAGLSRRGLADARGPRGAAAVLTARLRAATGTVHLVVDGAARTIAVALLEPTGASVVTQRQGVDDLAVVDVAVDRVPVVLAGLVPHVPRADTTPLSLPVGALRAAEELVVGAAASADALERLLVEHGVDRATQRRWVACLRPVLGGGQAGAGRETASRWLDTPRGRYRLAERDGWISANPLRPEDLTRDLADAVRRATGSTVDSPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2W4</accession>
    <name>A0A7W7T2W4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="31714" checksum="DB1AF87A27C344BB" modified="2021-06-02" version="1">MSETLTLRIRTTASPERVHQALTTAADLEAWLAEHASAAPFGFWGRYTPEGDAPHQEVVHVDARTLRFTWKVGGETTDVAFSLTPWESGTLITLEQSHFPGWESAVAEDSVLGHLYTYWTLGLANLVDHVEGRQVANRIDFTSAEMRGTVHIAAEPEVVARSLVDAESYERWFGARIDIEAWVGGRVAMGGLDANPHPATVLVYEPGKRMDVDWHGMVSGWELEGTDGGTRLTFVQSGFDPANPPYSAWGGWLAGVVELRRFHELADWRPMWLAPDVPGLPEGILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T365</accession>
    <name>A0A7W7T365_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="14"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="10890" checksum="2E9C54DB016E0F4F" modified="2021-06-02" version="1">MTTPVRFTADEDPEGRTVLAVHGEIDMSNAAEFDQALRAALERGRPLLVDLTATGYLDSAALAVLFEHASSLSLRIDRTLRTLLSICGLSDLVPVEVVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T379</accession>
    <name>A0A7W7T379_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="338"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="607"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1349" mass="144263" checksum="204C8377CEFBF051" modified="2021-06-02" version="1">MNPSEPTFPGTGEMSRRLRAYPWAEADMDEPPRWPSVLRAAVRICLTSRFPMIVWWGPDLRFLYNDAYLPLLGANHPALGKPGRLVWDEIWHIIGPMLDSVVATGEATWSEDLLLPMHRHGYLEETYWTYSYSPLHDDEGVVRGVFTAVSDTTERVVGERRLAVLRDLGALAGRARTVDEACRSVVDTLAHAGMDVPFAAVHLPDPESGGLVPVAAGPAPFTGSPDGWPSAEVVRTGRPAVVDDLAARFGPLPAGGWAAPPTQAVVLPLTGDDGRPIGAVVLGAGPGRMLDEAHTAFLGLVAQQIAALVNATVAYQAQQRRVEQLAELDRAKTTFFSNISHEFRTPLALILGPTEELRSGPAADDPAVREELEVIHRNGLRLGKLVTALLDFSRIEAGRMRARYEPVDLARYTAELAGVFRSAVEKAGLAFEVDCPPLAEPVHVDRGMWEKVVFNLLSNAVKYTFDGSVRVVVRAEDRHAVVTVADTGVGIAAAEIPRLFERFHRIETARSRSNEGSGIGLALVRELVLLHGGGITAESTEDVGTVFTVRLPFGSAHLPAELVHAEAGPVGVSATADPFLQEALRWLPEDVPGAPPVVAHRPDTGVRVLVADDNADMREYLERLLVPFYAVQAVPDGLAALEAVRAAPPDLVVSDVMMPRLDGLHLVAALRADPATAGVPVLLLSARAGQEASIEGLAAGADDYLVKPFAAAELLARVRANVELARLRNRHVRWRTAITQSLQEAFFVCDETGAVVEINAAFTRMLGHGPEGLPYRSPLPWLPDGDADPEARRLAVEAFDRVAGGEGGHCTAPVTDRSGRRRWIALSFSRVEDPDTHRRVVVGTFRDVTAEHHGVRRDTALSAVGVRLAAADDPAEALAGTIAELRLIWQARRVLGIVVGTDDSVTSTDGDVTEADLPSAIADLRTAPLLTPVDRGDEGVGIALDHPEGRLVLWVEPDGRRPFAPEDRMLLALLAGHVGQALHRIHRGEQQRKAALALQHAILGPALPGGFAVRYEPATRPLEVGGDWYDTVGLPDGRLGIVVGDCVGHGLDAAAVMGQLRSACRALLLQDSGPARTLMAMDVFAATLRGARCTTVFCGVLDPETGALTYSSAGHPPGIVVRPDGTRALLDGGRSLPLGVRPGRERPEVTTTVSARSTVLLYTDGLVERRGQDLADGIAEAGRAVAEEHALPTDDLATALMARLAPADGYSDDVALLLYRHPGPLEVGFPAEPGHLARVRARLRDWLARCAVPTEQAQSVLVAVGEACANAVEHGHRDVAGTVVLSAAATAADLLVTVADGGTWKRPDENANPHRGRGLPLIRALTDDVRITSDATGTTVELRTRITTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T385</accession>
    <name>A0A7W7T385_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7751" checksum="DDBB15456EBE4032" modified="2021-06-02" version="1">MVLRFDTFAKAMALAGFRSDAAVARAMRVHRSTVKRIREGELLPGPAFIAGALSALRPMEFTDLFVAVEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3B1</accession>
    <name>A0A7W7T3B1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="5">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28436" checksum="C21C4EEFE8B29B57" modified="2021-06-02" version="1">MLRIALLAVVLLCLAVALGWRLTGGRWLSVDSGSMGETAPVGTLVLTRPTTVAEVAVGDVVSFYPTAASKIAYTHRVVEIRDGKLITRGDINGADDPWRTGDENLVGLVVARWWGVAWLVKSLPFLLVGGFTVWLLTRWTGRWRTPLRLILYPLVVCVAIVVLRPLVGVILLGTFTEGDVTRAQLVSSGVLPVRATTPDGVFTDLRAGQVGELTASASKYGDGGNVPIEVNPHMPWTWWTLCLVLCAIPLLVSFFVRPRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S4</accession>
    <name>A0A7W7T3S4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025851">
        <property type="entry name" value="SUKH-4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14435">
        <property type="entry name" value="SUKH-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23454" checksum="B7D374586FE170EE" modified="2021-06-02" version="1">MKLHDMREVVDRILGQDLDFLSLVDGAPVLPGSVLGEWRIAADEKEVLALYGLPPARADGLMGIVGGFQESGTPTVARDGRRIYILGKLGISTLAVVEGGGDVFSFPQSSEVHPGLKHLYPDGMLPRLVNSSIARFVRCAWLWNALLPLLAEWEKAAGQCELAQARAGKVDLSVDPYESYLALCHHLLGQFREIDSEILEESSFWKDQIIDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T3</accession>
    <name>A0A7W7T3T3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YjbI with pentapeptide repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24336" checksum="B9F9164E984554E9" modified="2021-06-02" version="1">MDAEKSLAIDDRQAAVDAVCATLRGPASPDVREEARAFLLRHLTPGDDFWPDMDVDLTGAALDDFALAGCRLRTGAFSGAGFAGVTHFGFATFDGKVDFTDAVFRSDAGFDNVVFVGEARFDRAKFGADAWFIEAVFHDDAGFDDTDFVGDARFSDATFHRDCGFDRAAFHGFPTFSGTTFAGATRFHDATFDVPPWFHDATFHPDSRPEGALAAWRAEYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T8</accession>
    <name>A0A7W7T3T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12368" checksum="DB1A94C208F0B9C3" modified="2021-06-02" version="1">MGTSTDAAGEADDYFDKALDARHRAKDATGAERADLLAQATLDIGIATFFELRRANLDTEAHTRALTRHGGRLDEHYRALLGHADALTKQALAMDRHGSALEEFERSSRRMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4D5</accession>
    <name>A0A7W7T4D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5423" checksum="6ED9023EA42240B2" modified="2021-06-02" version="1">MIVHGAPDDEELAALTVALLALPRAEEPDETPAASAPLWTARPYRAPGAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T532</accession>
    <name>A0A7W7T532_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031154630" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7272" checksum="034D7F787841B7B2" modified="2021-06-02" version="1">MGALLLLLLSTGTASASYGLVGPFPSREACREALLGYLEAGWSAGGCGYVDEPGTHRDGYYFRTYAPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T540</accession>
    <name>A0A7W7T540_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31422" checksum="A33C3ABD01BADB30" modified="2021-06-02" version="1">MMARGGMIGLLTRRVAQSRRGGTRDSWYTRGHGDGWFEHLQETLARARHATRFEAEVSILKVLAIAHLWHGRTRESIETFGRVLDLYRDHEDWDGVGATLNNLGAAHAELGQDTEARALYQQAVDLHDTRHPRPQHAGILANMALVVARQGDLDTARSLCERALAMVADHPPPATGPVASTAYGHLGIVHRLAGRVDLAVEALGTSLLLARQAGDRLTECFFLNEMGETLRVGGDLPEAVVNFRRAPDLATTMNHSPQASRAHAGITDCGPAHLSHGTPPPRTTHGPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5A1</accession>
    <name>A0A7W7T5A1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized SAM-binding protein YcdF (DUF218 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="44"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="22835" checksum="30E9C63BC05F6408" modified="2021-06-02" version="1">MNGERYTSAQVAAITDYVDVTAPPPGIAAHFIFGTNQATPVDLVVDRYNKGLAPLVIATGGVNRRNGIVEAREFRRLLLENGVNDSGIRQEDRSANTWQNVEFSLPYLREAVDRDLPVAVVCKWYHRRAIHCLRTLFPDAREIYAITYEPIYSDVPITRENWYEHPDGNRRVIREWDEVSRRVADGTLQPLRRSRGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H1</accession>
    <name>A0A7W7T5H1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS_C" evidence="2">
        <location>
            <begin position="79"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="25325" checksum="ED16CAD79327AA75" modified="2021-06-02" version="1">MPPSPAAPVVLSRRRDDADLPPSVAPGSAESGLFLPYRPPHHPLLAEPARRRGAADGLCVTTTGVGLPIGDAQPSAAGRVGDVVLLSGPIGAHGTAILGTREGLGFEAESESDGRPLDGLVAAVVRAVGRDLHVPRDPTRGGLTGALDELAEASRVAVEIVADDVPVPRPVAAACEPLDLDPPHVADEGCLVAFVPPGGADAAPRSVAAGTRACVIGRVTDGPAGRVTARTGIGSTRIVDVLVGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L7</accession>
    <name>A0A7W7T5L7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YkwD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031484653" evidence="1">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17141" checksum="F06B47140F4ACF2F" modified="2021-06-02" version="1">MNAVARRIATVAAATGLAFAAFLTTAGAASAATTPSFETQVLTLTNKERAAAGCAALKANTQLESSAKGHNDEMAKTGKMTHTGVNGSTPGQRIDEAGYYWRMAGENVAYGQRTAEQVVRAWMKSPGHRANILNCGYKDLGVAYTTDSKKRAYWTQNFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M1</accession>
    <name>A0A7W7T5M1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="44934" checksum="9246FDED212AF277" modified="2021-06-02" version="1">MTTEHVPWHDPRRDDTERTVTARIRTHDAANRRHRALDDAFHLLSLPTADPFAPARRLALIARLMARSGRRVGAAHHADLARRALPLGGGREAVRITDVLHRVEDECVARVGPGAPAGSDRPRRPRVTGLSAPTGYALGRAREALLWLDSTVETSRFTTRWPRTVMLREARDSARLDGLPVALVELLHQALYRAHPTHVDSDLSPYLYGVQGPTPPTPAPEPGMPTTLVLTHMRRLVNPQATPAARHAQRLGLVADAVHDGLLTRPVLPITGRLADHAETFRHLADAATTKAGTDGFVRFLAEGIIAACHHEIALVDALPGLYDRLAGRLPHNPGRFQRRVLADLVAHPVTSGPDLVRRHNTTSRTAFNTITAFRDAGILLPHGTTKYGRTVYCPAALELVHHHDTTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N9</accession>
    <name>A0A7W7T5N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type phosphate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031121084" evidence="1">
        <location>
            <begin position="28"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="33391" checksum="9515B6F128260CE6" modified="2021-06-02" version="1">MRSTLTKAAVLVAGLATFVTLGGTAQADPGAGVTPATTDLVGVGSDTTQGLLNTLGNLYNTKTPAPANKVYSWDATGSATITPKSGAPTITRPNGSGAGVAALIADGTTHNLDFARSSSGPKTDGSQANYAFIEFARDTVTYATATTSSVPTTLTTLALNKLYGSAAGSVDCNRNAYLPQAGSGTRSFFLASIGLTTPGTCAKDTFAGAPVQEHSAAPLVGDPNAVAPFSVGRAIGLAGIKVNTIDDSVRPTGKAPAVTARVSPTTGQTVTSGGVVAYDRPLFNVIRKADKTVAKFSGFFGSLGYICTNANAKAAIDAAGFRRAPGCGTDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V1</accession>
    <name>A0A7W7T5V1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045512">
        <property type="entry name" value="DUF6480"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20088">
        <property type="entry name" value="DUF6480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14162" checksum="9EE9BFBCE8732A54" modified="2021-06-02" version="1">MTTPKPGHRATDHRGHRTAVRGSAGTPRLTPPAPRQPAPSRPAAAKPVPEPPYGHVPDLDTSVDPDPVRTPGLEPGGGVAPGDTPPESGQTSGLSHRERTPARRLQTAAIIILFVIVLLSLAFLVSQVMGWTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T678</accession>
    <name>A0A7W7T678_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="35104" checksum="96EF202DD63B41D7" modified="2021-06-02" version="1">MTDPWPRGTMPAVLLTAPGRVERGEVPIPDPVPGEVLVRTRYVGLCGTDLELLHGKATYVRDGRTTFPHVPGHEWWGEVVAADTGFVPGDAVVGHTMVTCGTCARCAVGRRQQCLRMAEVGLYGRAGAAAEYVRVPAHALTRLPGALTVPSAVLVEPAVTVVEALTRAGCRAGERVAVVGTGTIGLLAVQLAAWREAQVVAVGVDPAGLALARRCGAAEAVGVAEAPGRSFDLVVEASGGIDAFGTAVRLTEDGGRIAVVGVSGAAEPVVAGDLVLRGITVYGIQHGLDHYTETVALFAGGVFDGGPLVAAVLPAYDPGRAFDLLEHGRTGPPKVILGAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I8</accession>
    <name>A0A7W7T6I8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDGSH-type Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7499" checksum="D44F86C96208517E" modified="2021-06-02" version="1">MTAERATITSYENGPLLVRGDFELRTHDGEFIDPGRGTVALCRCGKSALKPFCDGTHKAANFRASRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6U4</accession>
    <name>A0A7W7T6U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="66"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30122" checksum="AC186F547851DF1F" modified="2021-06-02" version="1">MSSVLFDVPGPRARVRHRVYGVVGALAVVAVLAFVAYRFAVSGQFSGSKWTWIEYTKIQTDLLAALLNTLKAFGAGAVLALLFGAVFAMARLSDHAVIRVPATVVVEFFRAVPLVVLIFMFHYGLALGAPFFSVVLGLTLYNGAVLAEVFRAGVLSLPRGQSEAAYALGMAKSQVMRLVLLPQALRVMLPAIVSQLVVLLKDTALGFLITYEELLYYARYLGGDFQFGRPLVPITISVAALYIAMCLLLTWLATTLEKRNRRSRKVVAAPQDDPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6V3</accession>
    <name>A0A7W7T6V3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="34181" checksum="F7DFB3C5F64085C9" modified="2021-06-02" version="1">MKLLVTGGAGYVGSVCAARLVEAGHEVVVLDNLSTGHADAVPEGARLVSAAIDDVIEDVLAEGYDGVLHFAAKSLVGESQQDPAKYWQGNVVTSLRLLEAMRRHRTPRLVFSSTAATYGEPEVVPIPETAPTRPTNTYGATKLAIDHAITGYAGAHGIAAVSLRYFNVAGAYGRFGERHTTETHLIPLVLQVALGTRADVKIFGDDWPTDDGTCVRDYIHVVDLADAHALALANAVAGEHRIYNLGNGFGFSVRQVVDACRAVTGHPIPAEVAPRRDGDPATLVASSDKARAELGWTPKRVDLDGIVRDAWEFTQSRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T749</accession>
    <name>A0A7W7T749_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR04222 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026467">
        <property type="entry name" value="Ser/Gly_Cys_C_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04222">
        <property type="entry name" value="near_uncomplex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="31346" checksum="5DAFBEB13F6622CD" modified="2021-06-02" version="1">MERPWGITEQGFFELYWIALAVTIVIAILIRVRLRGQSDDAPAGAPDVHVLAVLVGGARRVAETALAELIAAGDVRLTRDGTVTATQGVPSARDPIARSVLRDVERPPLVLARKTLWGQVHTVRHAEAVRLATGRAVEAGLLADPRRALRSAVLSLLPLALLFAVGLARWASELTVGGPVGWLSVHLVLTGVLLAALPKVIAVGLTARGSRVVARTRTSAGVGGWRATGSAGGVEPVALHGIERHPDPEVRDAYVAGRPLPRTNGGGRSTAAAYGAGAGAACGSGSGCSSSGCGGGSGCGGGGGCGGGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T773</accession>
    <name>A0A7W7T773_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ORF">F4559_004960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="201"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="369"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="48255" checksum="2C6CD295FF086262" modified="2021-06-02" version="1">MAAAKTTQAAKADAEETPKATSARKAPAKKPAAKTGAAKTATRAPRKTAAKAAAGPVKAKKAGEGDEPEDLEAAPDAEDLVDDVELIDEPVEEEPAEEETAKPGEGDFVWDEEESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYAAERVRRAEEESEKLTPQLRRDLRWIVRDGERAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLATLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H9</accession>
    <name>A0A7W7T7H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030747085" evidence="1">
        <location>
            <begin position="29"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33401" checksum="EE585407A116C48F" modified="2021-06-02" version="1">MPLTRRSLFTAGAVAGGTLLLPVPRASAEPRFDGWPDWLGAHRDDVALVVDDGRGGRISHRPHAPQPLAAAAMIEHLAAYREVRPEGRVTVGDWERYLPGQDHGAALAHLGITSGNGVTADDPHALVTLDDLAGVMIRFGDTAAADLLRDRLGRPGLPSFLTERLRLVLRRPVSAQEYLADPRLQLEVIGRSPDVPGYAGRADWARDTWPGTAAAVDRTHRLLAGDALLEAGHAVPPKMAGIGVADIGRLGGALPGIVTLGVTVRWPDGRLGSATLLTRGVDEARYADRGALPDLLTRVLLDAAVLGELRDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T9</accession>
    <name>A0A7W7T7T9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030517840" description="VWFA domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="35"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="39081" checksum="22CC96789C0BDA4D" modified="2021-06-02" version="1">MKSTLSIVALLLLLAPAPAKADVPNPAWPSRCPLKLGLLIDQSYSMSSRFVEVREAASNVIDALRDKKSEITIIGFGGVATTIDSAVDVSDDDDRRALKETVKRIDTGDSGEGTNWEAALTDIAPLDLDVAVVITDGQPNTAAGGDTTDPVAAAVVAADRLKADGTRLVGIGIDLPPEGAVNLAAITGPVPGQDYYADDTVTLLRRLYDIVANSCGVPIDALPRPEPATFPWREVLLGAGALLLLLGLVAFGLHRKRRAPVTVTPTRRKTRIETPTIEHGTVAERLRTQAAEEQTRRDQAARDQADAKQAHEQQPTPDQTQRDQVAEQPGHEAVRQEDTGRPQRRSMSIDFLNREPPTKKDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W6</accession>
    <name>A0A7W7T7W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024787">
        <property type="entry name" value="EcsC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12787">
        <property type="entry name" value="EcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24115" checksum="D99D43450C7EC8D9" modified="2021-06-02" version="1">MVEERGLARVGQGAIENLLRVGIEGFGPFKSAQAMAAEALGRGLSRDEAVRYLIRRHVAAAGVQGFATNLGGLITLPVTLPANIAAAYLVQTHLIASIAAVRGHDLESDEVRTAILVCLLGNAGTELLKKAGIRVGAKLTMNLIERVPAHLIREINKRVGFTLLAKYGTSRASITLAKGVPLVGGVIGGGFDAVTTRAVGAFAHRFFSERADFDQPLVIDGEVVEIIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W9</accession>
    <name>A0A7W7T7W9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplU</name>
        <name evidence="6" type="ORF">F4559_005290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11360" checksum="E005AE92B950ED88" modified="2021-06-02" version="1">MYAIVKTGGKQYKVAVGDVIEVEKLEGEPDTEITFAAPLLVVDGEDVTSAVDALAKITVTGKVVEQTKGPKIRIHKFKNKTGYHKRQGHRQKLTRVEVTGITGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T826</accession>
    <name>A0A7W7T826_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase B (Cyclophilin B)</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10669" checksum="538CF9E787C78EA3" modified="2021-06-02" version="1">MSQSYPPPPPGYHPTQPRGTNSLAIAALICAFVFSPVGIILGIIAKKQIRQTGEEGSGLATAALVISIFFTVVAVIAIILSFVVFAAAVDQINDLPNYVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T890</accession>
    <name>A0A7W7T890_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="2">2.4.1.266</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.266" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="32167" checksum="FB7F3E71892AC534" modified="2021-06-02" version="1">MRDWFAARTWQSPEWTVEELVRAKGGRAVSVVLPALDEERTVGAVVAAVLPLVGGLVDELVVVDSGSRDDTVRVAREAGARVVRRTDVLADLPPWPGKGEVLWRSLAATSGDLVVFLDSDLVDPDPGFVPALLGPLLSTSGVHLVKGFYRRPLHEAAAGGGRVTELAARPLLNALRPELAGVVQPLGGEYAGTREFFESVPFAAGYGVEVGLLLDACDRYGLAGIAQVNLGVRRHRNRSLHDLGPMARQVVGTVLRRCGVPTTSDTLTRFVPVAGEWVPDPVDVLVADRPPLRSVCQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A6</accession>
    <name>A0A7W7T8A6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12221" checksum="1CFEA3C311A6B44C" modified="2021-06-02" version="1">MSLEPVVVVVDDDIDVRARPVLLADVLRTTADTVESGVAWAAAAFARLPGLSLVAVDLPRRRVALVAADRSVRVADERPGLLSEYYAAWAAGRASAGRAERVQPLADGVGRDRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D8</accession>
    <name>A0A7W7T8D8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13345" checksum="540EE5D27695B7D1" modified="2021-06-02" version="1">MESSTADTGVTDSLLWKARFGEVVRGMVVDFAPRLFAVVQEYGDRVDGRVAAWGMAFPDHAEVVSVEGGLRMTLGEVDSVLPAFATREGVSASVVWLPAFNARLTEPVDVVDDVEDETEPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8L4</accession>
    <name>A0A7W7T8L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein YabE (DUF348 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="304"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="469" mass="50244" checksum="2954C283359EFF98" modified="2021-06-02" version="1">MSSFNEDTDWFTPVKSTSVDVLDRPEPSEWDTTVFSITPDDVLEVLGPDADEVLANANVDVDELIRLINAETTLLPPIIFPDEVSQAGPALDEPDAPPAALVESAGKWKRRFLKAAVAAVLVSIGGGTATAYAMNKDVTVDIDGEVRTVSTFDDTVGEILADEGIAVGEHDALSPSPQAEITDGGRITLDRGRLVKATVDGEQREGWVRSVNVGEALDQLKVDDEGAWISQNRDMAVPLAGLSVEVKTLKTITLFDGANEARKLDTTALTVDELLKTENLSLGPDDKLETAADLRITDGAEVHISRTGVSVINATEPIQPPVEEVKDDTLMRGEKQVVEPGEAGEQIVTYRVTVKNGKEVGREKLGVKVTKEPKAKKVKVGTKLPPDGAVWDKLAQCEATGNWAINTGNGYYGGLQFDKGTWDAYGGSAYAAYPHQASREQQIAIATKVRDARGGYSAWPACQAKLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8L8</accession>
    <name>A0A7W7T8L8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">F4559_005952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="137"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="36688" checksum="4D77CEC81EA3B748" modified="2021-06-02" version="1">MTRLRVGIVFGGTSEEHPVSVKSARQVAEHIDTRKYEPFWIGITKDGTWKLCDGPDTDWEDGGGRPAVLSPDRGVGGLLVLDKGQYEEVALDLVLPVLHGRFGEDGAVQGLLELSGIPYVGCDVQSSALCMDKSFTYVVAESAGIATPSFLIVPPGGVPDADALTYPVFVKPARSGSSFGVTKVSAAADLAEAVEIARQFDSKVLIEEAVVASEVGCAVLGNDPDLVTGEVDRIALTHGFFKIHQEADPESGSENSTPIVPADIPAEKRTLVQETAKAVYRALGCRGLARVDMFLKDDGTVVLNEVNTLPGLTPYSRYPRMMAAAGLPLGEVIDRIVAAALAGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8R3</accession>
    <name>A0A7W7T8R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="247"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="486" mass="54866" checksum="EA4708911952B8EE" modified="2021-06-02" version="1">MSGRWVDPAPFEGARPRVPWWMLMPGRLRWLAVLVFLVWSLVVAVVRLVFVVLRYPIAAVVLAGSAWVWWRFGLSPLVLALLSLVAALELWWGLWRRSFLRWFWLRVVTEWRRATVYVPRWRSVVRLSGLVGRDRGREYRPRLRRVRSEGWRDRVRVRMVPGQAPEAWEARREGLAHSFGARSCRVRVLRPRVVELDLVHSDPLARPVAVPPLGGVEVDFRRVVVGVTESGRPWRLRLLGAQVLVVGVPGAGKGSVLWSLIWFLAPAVRAGLVRLVGIDPKGGMELGQCPEAFDRVVYDNGPDAVALLEAVAAEVKERASRYRGVRRLWTRSAGEPFTVLVVDELADLVAYQPDKGLRERAVRAVQTITSQGRAPGFAVVGLVQDPRKEVVGFRHLFSTRVALRLDEPGQVDMVLGDGVRERGAAAHEIGEDTPGVAWVKQDDRREPERARAFHVTDADLVELRDYLTYGQVHELPDDGDQWQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W8</accession>
    <name>A0A7W7T8W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016602">
        <property type="entry name" value="UCP012666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012666">
        <property type="entry name" value="UCP012666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="55603" checksum="F4EA8B9F2E63A364" modified="2021-06-02" version="1">MGRGVSVRTFTREDRRRHRERVQRCLDALGTMLAEDTFSFPRQQMGLEIELNLVDGACRPAMANAEVLEKIGDPSFTLELGQHNLEVNVPPRELAGDETLGLERELRTLLASADDKAHDAGTSIVMIGVLPTLRQEHFHRRWLSDQPRYALLNDQIFAARGECAELVMEGSPLPGSAAERLDTYAESIVAEAACTSVQLHLQVAPGDFAAHWNVAQALAGVQVAIAANSPFLLGRALWHETRIPLFLQATDTRPAELRNQGVRPRVWFGERWITSIFDLFEENVRYFPALLPETGDEDPLDVLGAGGTPTLSELRLHNGTVWRWNRPVYDVVDGVPHLRVENRVLPAGPTVLDMMANAAFFYGAQRALATLDRPLWTQMSFQAAEENLYAGSRHGMGAQLYWPGIGWIPPDELVLRRLLPLAHEGLRACGVSDSARERYLGVIEARCLTRRTGSQWQRETVTLLEERGATREQALSGMLARYVELMHHGEPVHTWPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D7</accession>
    <name>A0A7W7T9D7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="34543" checksum="061A7423B081D02B" modified="2021-06-02" version="1">MKTFGRTLLATTALGTATLAYAAGIERRNWTLRQATVPVLAPGSTPLRVLHLSDLHMLPGQKSKQRWVAALAELEPDLVVNTGDNLSHQQAVPAVLRALGPLLDRPGLFVFGSNDYYAPRPKNPARYLLPSAKTKRIHGVPLPWRDLRAAMIERGWLDLTHVRRELEVAGQKIFTAGLDDPHLKRDRYADIAGPVPEAALRLGVTHSPEPRVLDPFAADGYDLVLAGHTHGGQLRVPGYGALVTNCDLDRSRARGVSRWGAHMWLNVSAGLGTSPYAPVRFACPPEASLLTLVPRAEAAGQTPPTTERDTRFGVGGTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F3</accession>
    <name>A0A7W7T9F3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="108"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="32616" checksum="78874C549AB9027F" modified="2021-06-02" version="1">MVTPTGKKERIDALAESTAKGDSGVSLAASAWKRLRRSPVFLVGLVIIGLFLVTAAIAPFIAPHDPAARDLIDQVVKARNEIPPAQPGHPLGGDLVGRDFLSRLLVGSQQTLLVGVFATLIGLAGGLILGTLAGAFGGIVDSIVMRVVDVMLSIPQLLLAFGIGALFAKPNLFTVILAVSIVQIPVFARLLRGSMLAQRGSDHVLAATALGVKPGPIVFRHMLPNSLGPVIVQSTLVLATSIIDAAALSFLGLGNPDDTVPEWGQMLGNAQTVIDSHPHLAFWPAGCIIVIALGFTLVGESLRDALDPKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I2</accession>
    <name>A0A7W7T9I2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="6">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tilS</name>
        <name evidence="9" type="ORF">F4559_006250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015262">
        <property type="entry name" value="tRNA_Ile_lys_synt_subst-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09179">
        <property type="entry name" value="TilS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TilS" evidence="8">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="31992" checksum="69EEB47441BCF9F3" modified="2021-06-02" version="1">MNGPLADIRTAVRRFLAGHEPERVTVAVSGGPDSLALAAVTARLAPDARAHVVDHGLQPDSAAVAARAAQTLEGLGLPTTVTRVTVDGPGGPEAAARAARYAALRPDRGVVLLGHTRDDQAETVLLGLGRGSGPRSIAGMRAFDPPWGRPLLGVPRSATVAACAELGLDPWTDPHNADPSFTRVRLRTEVLPLLEDVLQGGVAEALARTAAQLREDCDALDDLAAAFEGDCRAVDDVDGLPTALRRRVLRRWLVGEGVPELSDSHLRRVDALVAEWRGQGGVWLPGGFVARRAHGRLQVEQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T9</accession>
    <name>A0A7W7T9T9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="38443" checksum="859672082B2B5B3D" modified="2021-06-02" version="1">MDPARILAASTEITSAALAGDDPDSVLPLVVRHAAEVAGADLGLAMITASDGTLAVEASSGTAGPIGVVLSSRSSAARAARTGVPVTADDFTTDPRTAPFVPRSLRGYGPFAVAPFGTRERRIGALAVYRKKGERPFSSDTVGVLTAFAAQAGLAVVLAEGFTARHRIAVYEERERIARDLHDVIIQRLYATGVQLDLLDRRLKLEGREARRLAECVDQLDATMAEVRATVRALRSADPAGRVDADLRGSILAEARIAGELLDREPDVRIDGDLTGVPAGLADHARAALREALSNVVRHSGALQVSIVVGCVGGRLSVEVSDDGCGIPGGVARRGLRHLEERALAAGGTCEVRSSALSGTTILWSVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA76</accession>
    <name>A0A7W7TA76_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26803" checksum="2EBAF68B5E69B6B9" modified="2021-06-02" version="1">MTTVTALDVRRLFNVTQETRYRFNGRHGDDKIVMPYLMDHVAHVVHRIAVDAAEAACRSAPDPGPPCPVPEVDAWRAPSGVVAHRAVEVLGRLPDWPGFREFCRVDDRARSLLWEPARELAAGGSREVARAVRRRVLTDYTAFLADMYVLAVLRGYGLDVRVHPLADLVFEVDAWVGRLVLDLRGGRRRAEALLVHAMPPFFFGDLKITAHDRIGAVTVPDRAGLDRAVRRLRKVLYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAI6</accession>
    <name>A0A7W7TAI6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="20">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="20">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">lysS</name>
        <name evidence="23" type="ORF">F4559_005609</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="20">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the LPG synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="20"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20 23" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="17" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 20 23" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="22">
        <location>
            <begin position="771"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1002"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="MBB4968250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1090" mass="118724" checksum="7E5B426604F6CC90" modified="2021-06-02" version="1">MFVAVAGWKWRVAGAAATVVQLAALASLVLLVSDEGPLSDAIFLGGFVLGLPVDANLFIVLVLLVLGAALRRRKRAAFLTLLLFESLGLGLVLLLGALLVVAPAETLADPADPVFGEAVVAEIAGLVCLSSFIVVLWLSRDAFPAKLAPGAWRRALAVFVLGLLAWIPAGWGLTCVFPGTLQGTGEKFVWAANQVVGEVLPLERAGVGTGPQWLSVVLGLAGTVVAIVALYVFFRGERSSLLVDDEQELAVRRLLAEHGEQDSLGYFGTRRDKSVVFAPNGRAALTYRVFAGTALAGGDPIGDEDAWPHAVEAWLAETRRYGWLPAVLGAGERGARVYTRAGLKALEIGDEAVLDVRGFSLSGPQHRSVRQAVSRVERAGYTVRVRRHAEIPPDGMAAILELARRWRGTETERGFSMALGRLGDPSDGRCVMVEAYDAGGELRGLLSFVPWGRRGVSLDLMRRDRTAENGLNEFMVNGLVAASGRLGVQRISLNFAMFRAVFEEGDRIGAGPVLRAWRRVLGVASRFFQLESLYRSNAKYDPHWQPRYLCFGRTRNLVRTGIAAGVAEGFVPSLRSLLKRGSGRALRYERAGADFVAAVAAIDAAKVEAKPVRRPEQVRVRLAKLDRLRAAGVDPYPVGFPRDVSLARARERFGDHVHVAGRVVASRELGGLCFARLRDSTGEIQLMLDAGRLPDLALWKYGVDLGDHVGASGEVVRSRRGELSVLVDEWTVTAKCLHPLPDGHKGFADPEARVRKRYLDLVVNRDSARMLRLRSDVVRAIRDFLHDREYLEVETPMLQAVHGGANARPFVTHINAYDTRMFLRIAPELYLKRLCVAGVDRVFELNRNFRNEGADATHNPEFTMLEAYQAYADYRVMLDLMRELVQHAAVAAHGRQVAVRGDGVEVDISGDWPVVPVYSAVSGALGVEVTPDTPVDRLRALLADRGVAADEDADHGALVQEAYDALVEPATVGPTFYTDFPTSVSPLTRRHRVDPRLAERWDLVAFGAEIGTAYSELTDPVEQRGRLEAQSLKAAGGDVEAMELDEDFLLALEHGMPPTGGLGMGVDRVLMMLTGTSIRQTVLFPFVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB43</accession>
    <name>A0A7W7TB43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty-acyl-CoA synthase</fullName>
            <ecNumber evidence="2">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="542" mass="56996" checksum="0E7E34704D06B2F8" modified="2021-06-02" version="1">MSRFVDTMVATATSAEGRKRGMTTGEPHEPAHRTWAQVHEHATRIAGALGVDRGAAVAVLAGDPAEIAPAVQAAWLAGGSITMLHQPTARTDLAEWAADTLRVLAMVEARLVLLGAPFDALAGVLDQHGVAYRRIADLDGPPLTAPVPVGEGDTALLQLTSGSTAHPKAVRITHGNLWSNASAMRVAAKLDPEVDRMVSWLPLFHDMGMVGFLTVPMLFGIDLVKVTPADFLRGPTLWPDLISRYGGTITAAPNFAYAIAARRMANVDDGAYDLSRLRIALNGAEPIDPAAVRAFVDAGARFGMPAECVMCAYGMAETTLGVAFAPAFTGMAVDTVDPEALAAHHRAVPSTSPDARTFPLLGPPLPDLEVCVVDESGAVLGEREVGQLRVRGEAVTPGYLTVDGPVATRDATGWLATGDEGYLVDGQVVVCGRRKDVIIMGGRNIYPTDVERAAASVEGVRAGNAVAVRLDAGTRRERFAVVVESKHADDEEAVRDLSRKIITRVVDAVGLRPFAVVVLGPGSLPKTPSGKLRRSAAAALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBB2</accession>
    <name>A0A7W7TBB2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14643" checksum="61F73B51723BF3C1" modified="2021-06-02" version="1">MEIRRATSVAEVLAAGHLFDDTPREDVTATFLAEDRQHLLIAYVDGEPAGFVSGSELLHPDKGVEMFVNELGVDDAFLRRGIGSALVEALLELSKERGCHGMWTAVDADNEAALALYKGVDGDMDTGVAVVTWDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT13</accession>
    <name>A0A7W7WT13_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="25952" checksum="8744938000092A2E" modified="2021-06-02" version="1">MNRPVAIVTGASAGIGEATARRLAAEGFHVVLGARRLDLLEAIADEIGGTALALDVTDADSVAAFLAAVPDQVRVLVNNAGGARGLERVDQADEDNWRWMWETNVLGTLRITKGLLPALIASGDGHVVTVTSVAAVEAYDNGSGYTSAKHAQSALHRTLRGELLGQPVRFTEVLPGMVETDFSLNRFEGDADRADAVYRGLTPLTADDVADVIAFAVTRPSHVNLDRIDLKPRDQAAAARIHRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTE4</accession>
    <name>A0A7W7WTE4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="20766" checksum="A8AA3819C2C20BAF" modified="2021-06-02" version="1">MSTKLCLAQDQEADELLSSSPLALLFGMLLDQQIPMEKAFKGPKVIADRMGGELSVHKIAEAEEGDFGAVMAEVPAVHRFPGSMGKRLQALARYLIEHYDGDAEAIWTRDEPDGKAVLKRLKELPGYGDQKARIFLALLGKQLGVRPEGWREAAGAYGDEGSRRSVADVVDQATLLEVRDFKKAAKAAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR1</accession>
    <name>A0A7W7WTR1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="96" mass="10567" checksum="7BB859F8FA9EF117" modified="2021-06-02" version="1">MTLGVKLLSVSGNYAVVHLDHRNFPALAIQGDSLKILQEAVEEFAECWDGGDVDDARYALAEVSETIRGMLLVYQEAAREQGFELPYFPGGRPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU19</accession>
    <name>A0A7W7WU19_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ilvC</name>
        <name evidence="12" type="ORF">F4559_001080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="36424" checksum="63C437AE83F41A64" modified="2021-06-02" version="1">MSVEIFYDEHADLSVIQGRKVAVIGYGSQGHAHALSLRDSGVDVRIGLAEGSKSRAKAEEEGLVVGTAAEVSAWADLIMILAPDTAQRHIYANDIAPNLNKGDALFFGHGFNIRYGLIQVPSDVDVAMVAPKGPGHLVRRQFVDGKGVPALIAVEQDASGNAQALALSYAKGIGGTRAGVIKTTFKEETETDLFGEQAVLCGGASALVQAGFEVLTEAGYEPEIAYFECLHELKLIVDLMYEGGIARMRYSISDTAEYGDLTRGPRVITASVKEEMRKILGEIQDGTFARQWVEEDDAGRANYKKLQSEGEQHPIEEVGKKLRGLMSWVDRPITETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU21</accession>
    <name>A0A7W7WU21_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polar amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="27566" checksum="49A270314348E97D" modified="2021-06-02" version="1">MTVAVQVTDLHKSFGGTEVLRGVDLSVRRGEVTCVIGPSGSGKSTLLRCLNHLEKLDHGEIEVDGELIGYRRHNGRLHELRERAVTRQRAGIGMVFQGFHLFGHLTVLQNVVEAPIGVLGVPRAEAEKHARELIARVGLAGREGAYPRQLSGGQQQRVAIARALAMRPKVMLFDEPTSALDPELVGEVLEVMRGLAAEGMTMVVVTHEIGFAREVADTVVFLDQGLVVEQGPPAAVIDAPTHERTREFLARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU42</accession>
    <name>A0A7W7WU42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="12786" checksum="B6DCE493FDBF4056" modified="2021-06-02" version="1">MSQSLITVIPQCLRGCDGRHLETPDLGPGECTATRVFGRTPHETNTNPNAVCVSVTRTADPDDGVHAWINLAHVDGEGWHDLTVTADQARTLIAALTAAVDHLDDTRLPDLLIHSTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU52</accession>
    <name>A0A7W7WU52_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="110" mass="12513" checksum="218AEDD730417008" modified="2021-06-02" version="1">MSEETIQLELNDTGVAVDLPLPAHQRDQVQGVPYRPVEFRDDDLPTALERAASWLRQTQDWLGEPVDVIAVHLDYDDTKGSPYYNLKLLCNDEDLAGVPRVVREHEASRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU96</accession>
    <name>A0A7W7WU96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4351" checksum="7BE7F7E1D22D2CC8" modified="2021-06-02" version="1">MDRSIWIVNVETMSNTLENVRLTIACLVLASAIGVAFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD5</accession>
    <name>A0A7W7WUD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22486" checksum="7F523116BE552008" modified="2021-06-02" version="1">MSTTALVAFAVAALLLTITPGLDTMMLLRMVLGGGRRAGVVGGFGTTLGCVVWGAASIAGLTALLIASRFAYEVVRYAGAAYLLWLGGSALYKSVRRRQLDEPVEVERTTPTRALRIGFITNLLNPKIGVFYLSLLPQFLPTTGGTTSWAVLLVGIHVLIGQVWQLCVVWLAGRAVLVLNRPAVRRFMERATASVLVAFGLKIALESGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV41</accession>
    <name>A0A7W7WV41_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0060 membrane protein F4559_002254</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0060 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00010">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="PTHR36116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="11626" checksum="E742AD85D3E34D24" modified="2021-06-02" version="1">MSVLRSVPLFVAAALLEIGGAWLVWQGVREHRGWLWIGAGVCALGAYGFVATLQPDAHFGRILAAYGGVFVAGSLLWGVVVDGYRPDRWDVVGALVCLVGVAVIMYAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV89</accession>
    <name>A0A7W7WV89_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6691" checksum="F464EF3F124A91B5" modified="2021-06-02" version="1">MASEDSVRWGEGRKPRRSFGANNCVEIAHAPGLVGVWDTKHRAAGPVVVGCRAWAAFLNTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV95</accession>
    <name>A0A7W7WV95_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase (GGDEF)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="423"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="567" mass="60472" checksum="77C381300AB6D803" modified="2021-06-02" version="1">MPALLDDVRFAFQPLFNLHTGGVVAIEALARPHDGSVQDLLRMAFRAGYLANTDVALACRAIRHAADHDVLLPLHVNLLAMTVADKPELMAPLYAALREVGRTPADIVVEVGTPYSRAPRGRLEKGISRLREDGFKIGLDGVGEGDTPLSLLAGVQPEVLKLDREVVAALPEDAARYALVQALQHLGEQTGSLLVAEGVETEAQLAAVRRLGIRLAQGNLLAEPQRRPRVGATIEAVLSEVNDPEAVTKTMTGPLRRKAGPKVTDFLHPATTLPETATSEEVLEILTAQPTVSGVVLVCPAGRPRWTVDRNRFLLSVTGPFGHALHAKREAHRLADKPKIIGADSSALDLLDVVAHAHRERTNDDLVVVDRADRCVGVVRVADVVRGIAELKVEQAAALSPLTRLPGSDAIAREVDRRIMHGEIFAVGWLDVDSFKRVNDTVGFAAGDDLIRSIGRRLTEGAGASSSIQVGHVGGDDFLVVAGLDEVVPFGTGVLDTVYEAEGVRVTLSLATLVCAAGSVGSYREVSRLLAPLKEHAKSLRGTSWVLGRPGSDHVDVLRGGPHLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVK6</accession>
    <name>A0A7W7WVK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tryptophan halogenase</fullName>
            <ecNumber evidence="1">1.14.19.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.9" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="578" mass="64082" checksum="88838023993883A5" modified="2021-06-02" version="1">METNAGRRSELDELVSTFPDDEAAAVRGWLGGAAGTSHLPGISLRSNHEPLVEKLPRPAAYDPNAIRRVAIVGGGTAGYLTAIALRTKRPWLEVSLVESPSIPIIGVGEATVPGIVIFLHHYLGIDVEDFYRQVRPTWKQGIHFRWGPRPEGFMAPFDWDSNSIGTAGAVDSGSGIDGYTLQSLLMRTDRTPVFDAGGEQVSLMKYLPFAYHLDNARFVGFLTDIAKQRGVRHVEARIEDVVLGGEDWVDHLRTTDGRKLDYDLYVDCSGFRSILLGKAFGTPFLSYESSLFTDSAVTGNVGHGGHLKSYTSSITMDSGWCWGIPTPEDDHLGYVYSSNAISDDKAAEELAARFPGVGDPRVVRFRVGRYEKAWRGNVMAIGNAYAFVEPLESTGILMITSSVQALVASLPASWSDPQCRDMINVALANRWDALRWFLSIHYRFNTRLDTPFWREVRSTTDISGAQPMLDMYATGAPLRYRNPLLRTFLQGNTPTFYGLAGVETILLGQEVPTRLLHRAEPPERWRARRDAAMAITRRALPQNEALARFHDNPGLNRQLLFDPDSWASPLRAEPIGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW81</accession>
    <name>A0A7W7WW81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="23436" checksum="8CF498C5808D300C" modified="2021-06-02" version="1">MANRRERLREQTSAEIKAAALAHLREGGGAALSLRAVAVSIGMSPAGLYRYYPSRDALLTDLITEGFAALAEEVARARDAARGDAFVAAALAYREWALTHPHEFALLYGTPIPDYAAPESGPTSDASRKVGAAFVPPIIKAWRRGTLKRREVPPSLTALDRFAAAVDLPPDAAAVAFTAWTAIHGLVVLETFGHLAWLGGDPAPLAESRFQALSADLGIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB6</accession>
    <name>A0A7W7WWB6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPW_gp25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14950" checksum="14FA4E4711043834" modified="2021-06-02" version="1">MNDFIGRGWGFPLRVDPTGGIGMVDRDVEIQQAIRLILATAPGERPMRPEFGCGIHEHVFATADHATAGDIAREVRVALDRWEPRIEVADVVVAFDAVEVGTLYIDVHYTVRTTNDRRNLVFPFYTIPAEEGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH2</accession>
    <name>A0A7W7WWH2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030961640" evidence="1">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="33984" checksum="6DA40979D434E445" modified="2021-06-02" version="1">MRRMLGVVALLCASTLFVTPVASATHDPADAAAGWLARQLVDGERFETVYDGVAYPDQGLTIDAVFAFAAARAADDYADDAIDWLARPEITTGYVGSGGEAYAGPHAKLLLAARVTGRDPAAFGGVDLEAGLLALLTPSGRFSDQSAWGDYSNAFTQSLALLALDRTSAGAPTTAVDFLVGTQCPDGGFPLFFGVTPCVSDVDSTAMVAQALRAVGRPLKAGQGLSWLVSVQRADGGFAVGTNDSNANSTGLAAQALKGHRPVAAVKARQFLKGLQVGCAGPVGNRGAIAYQATGFDPATATRATAQAILGLAGVGLADLHSGGRNDAPVLTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWS4</accession>
    <name>A0A7W7WWS4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiopeptide-type bacteriocin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023809">
        <property type="entry name" value="Thiopep_bacteriocin_synth_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14028">
        <property type="entry name" value="Lant_dehydr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03891">
        <property type="entry name" value="thiopep_ocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_C" evidence="1">
        <location>
            <begin position="10"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33128" checksum="4ADB3B668A11CB91" modified="2021-06-02" version="1">MIRTTTAADWLAAHLFHHGNLDDLLVRLVAPLVRELDRPAFFLRYWDGGNHVRLRVLAPDDRDAVGAVIRDRAEAYFAESPAPDLMSAEHYRSVAPGLALGEGLTDYLPELRPNNSVLFQPYTREHHRYGHGASMEAAEHHFAESSAVVLDLLGTHPSTRQRDTACYALILLAWFAAEPDPVRLTAWRDRLDRGWAERFGPLGVVAEAESAQVFERDRGTLVAIADRLRAGRVGGSVLGRWSASVTALAASLRRPDARAPEGGPLPVLDACAHLLCNRLGVSPAAEVHLRRLAVAAVLEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX0</accession>
    <name>A0A7W7WWX0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16230" checksum="C6213C8E666C90C9" modified="2021-06-02" version="1">MRLSELLDLTSLDVLDHVAREIAVPVVDGPHAQGDLLVLPYDLVSSVVRIAGGLREVPRAGVELVRGAAGGNPHTLTADENSTRWTPGVHDPLGLAVAYLENATPAYLIHPEHGATGLAPGRWLVRRQREYVPLRRRVGSLPFGGGSVLVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX42</accession>
    <name>A0A7W7WX42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5181" checksum="45C6E8E055401DDE" modified="2021-06-02" version="1">MTDPRRRVRATTKSFQDAAGTGRLPAVDDRRAGSLTVAAVLSDSRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA1</accession>
    <name>A0A7W7WXA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="35940" checksum="A5E66E56D13F1DAD" modified="2021-06-02" version="1">MPAPVAGAESRLRDPRRIESGADPFADALRAAIRAKGLSLERLQHKLRARGVAVSIAALSYWQSGRRRPERPDSLTAVGHLEEILDVGEGGLSTLLGPPRPRGKARPRQRPTSPDGWLRSADYESMAELLAEVDTSSDQDLTRLSMRDQVELAMDGSTRRVRSRQVLRAERAGVDRVLLGYDTRLPGDSLPVIGTLRSCRLGRVSADPRQGLMIAELLFDRPLRRGERTAVEYELIHVAPHHPTYDNTHSRRFRHPVREYVLEVRYDSRCRPVRCEQFTTDVNGGEPTDVRETPVDTWGYAYAVALDFGPGVVGLRWDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA3</accession>
    <name>A0A7W7WXA3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15289" checksum="ECBAFBB01010655B" modified="2021-06-02" version="1">MAEPDVPADLQVVWGARVEIERGYRLEAIAVALSADIAELREDGGLPGHIHTRITVLPQHRLLEIRVEGLSVETDPDRTTSREVMNTLFELASDHNIITLDTVSPPLFTQRIVLVDPYGQPFAAKVGAGMGEPEPFTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC8</accession>
    <name>A0A7W7WXC8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="40748" checksum="A03D3CF50A5BF15A" modified="2021-06-02" version="1">MSADRGVEELLSAALGGPDAVTVRAALAGMVAALRSAGHADPAVVAAADRLAGLGSGGLAPGGLAPGGLGAIGQGSVGSGPGGQEAVGPGQGASGSGGPVERVAAGPPVGEFAADPDVATWLGATTLDALTGAPTEAQAWVRLWLAFLRLPPDLAETWRERVRSSRTGDAGAWQAVAGGDESLVDPLPEAGVTGLRESPDAAVHPWAADVLPERFATLRTLVGQVLTMVERDPGLHHALESRRRQDFHSLGDPANLRDFQRDAANRLGYLAAAPPGSVRELRELSLVDELLCSVVHVPPAHPESWWGRLARRSRALVAEAAAALRERGEDVEVRVVPPGPYDAQRPWIGRNNLSCPVPGRPPSQILACLRVYLRAGEEEYPGRVVYVRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ0</accession>
    <name>A0A7W7WXJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031231217" evidence="6">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="131"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="39194" checksum="234F7B8C244B915A" modified="2021-06-02" version="1">MTVLTLAATSMLTPVAQAATGDIRAADAREKVQNSFIVKLKDGSVADATALAQQYGGTVARVFKNAINGFQVRIPETAARKLAANPAVEYVEQDQVLRATATQTSPPSWGLDRIDQRTLPLNYQYQSTATGAGVNVYVIDTGIRTTHSAFGGRARNGYDFVSNDAIAQDGNGHGTHVAATIAGSQYGVAKGATVYGVRVLDDNGSGTTAGVVAGVDWVTKNHIKPAVANMSLGGGASVAIDNAVRRSIAAGVTYVVAAGNSNVDASTTSPARVTEAITVGATDRSDARASYSNYGSYVDIFAPGSSITSAWKTSDTAAASLSGTSMASPHVAGAVARYLQTNKTATPAQVQSYLIAQSTPSKVTNPGTGSPNRLLYLAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ7</accession>
    <name>A0A7W7WXQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (DUF885 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="558" mass="61151" checksum="3B700193BA09EDDC" modified="2021-06-02" version="1">MASPTAGVHGISNQFVSDYAAADPVTATMMGVPGHDERLTDFSADAVDARAELARRALAAVSAAEPADKSEADAKAVFLERVGVDVDLHDADEQLGALNVIASPVQMLREVFDHMPTATADDWAAISRRLAAVPAAVASLRSGLTEAAARGKVAALRQVTKIADQCDTWAGRSGQSYFAGLVAAAPEDGALRADLDARATDASAAFGGLADFLRADLAAKAPAKDAVGADVYRLWSRYFIGSRLDLAEAYEWGWAEFTRVETEMKRVAGRIKPGATLAEAAAALDTDARYLVRGKDGLQSWMQRLSDKALRDLRDVHFELPDELMRLECRIAPPGGGVGAYYSGPNPDFSRPGRMWWSVPADKEEFSTWREVTTVYHEGVPGHHLQVATAVYQADKLNDFQRLLCWVSGHGEGWALYAERLMRELGYLEDDGDLLGMLDAHLFRAARVIVDIGMHLELEIPRGTGFHEGERWTPELGLEFMLTRTITEPSHVYDEIDRYLGWPGQAPSYKLGERLWLAARDDARARHGDAFDLKRFHRDALEMGAMGLDTLRERLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW9</accession>
    <name>A0A7W7WXW9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="17473" checksum="ACD7A9A08F8BE771" modified="2021-06-02" version="1">MPLPRRPQPALVRLSKGVGLPGAIPDVLGLALRTEVRGAPWDVLLSSHAPGSLVWLPFPAARWCGARLSTLGGLEGVGGSGVLTATGAALPHSTRLDALCTASPMTFTLSLHDFGPVGEVSLTAIAKSPAPDFDPVVNAAGLELKPTWLGAIRARAYAGSRSGRGAPRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH8</accession>
    <name>A0A7W7WYH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030781577" evidence="1">
        <location>
            <begin position="34"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="33715" checksum="D48F016C4B0A3F0A" modified="2021-06-02" version="1">MRTLPKRFTLVGAVVALLVTAGCASGPSKVGTAAIVGGTVIPLEQVQQRLDRVLKKEPGAQAALKQHKLDGVARLVAGTAVQHELTLKVAQREGITVDEADIAEAIEDAGGAEAGSEGTVYDSTTFRDRAVDQLLQVALARKYVDRLEVTFDYFYSRDKNEALDKAAKIAKDPGLMAGYVNAAPKGNGNQQLAKRGQVIKSSQEPTAAAAPFFGVKPGTVVAYPPSEESAQWLVVLVTDRRDDAKPSEQSSSEQLTPQILERIGLRLVQYLGADLEIEINPRYGVWDVVGIGLAASEGERGGYVAEVAGPPAKRTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ7</accession>
    <name>A0A7W7WYJ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
            <ecNumber evidence="3">1.6.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="441" mass="48751" checksum="AA75CCE0C894A063" modified="2021-06-02" version="1">MAAVKSQPTRIVIVGGGYVGMYTALGLQKKLRSGEASVTVIDPQPHMTYQPFLPEAAAGSIEPRHVVVPLRKVLNRCHVVTGRATKIEHARKAVTVELADGHVEEYEYDVLVSALGAISRTLPIPGLPEVGIGMKTIGEAIYLRNHVLSRLDQANSTNDPELRKRLMTFVVIGGGFAGIETLAELEDMTRYALRYYDGLKQSDVNWVLVEATTRIMPEVSAKLGVYTVEQLEKRGIKCFLDTRVKSMEHGHVVLDDGTEFDSDTIIWTAGMKANPMLRDTDLPLDERGRVRCTAAMQVVGLPGVWAAGDCSAVPDLSRTEEDPNATCVPNAQHAIRQSKLLSKNIVASLRGRKPKDYFHKYLGSVAGLGLYKGVADVFGLRFRGVIAWFMHRSYHVMFVPTVNRKFRVLVDWTQALFSGREIVALGQIHEPKAEFDRATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ8</accession>
    <name>A0A7W7WYJ8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3152 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3152" evidence="3">
        <location>
            <begin position="129"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="36423" checksum="ED05E99B1415ACF7" modified="2021-06-02" version="1">MNRTSQGGRDTTPSEGVRSSPPEDRYRRGTRRTAAEPLAACWQPGADRRDKSSSGIKRLAKSYGWRVYAIPVLLVLTALVVIDTAVPSRVDRPAAETSAQVVPPPSGPPAATETPPVKVDLVDIPTAVLPEGPRFSEQGAGTWGTVLGTTGQIGQGRLYRYAITIEDGIDPADYGGDRDAFARTVDSFLADPRSWVGTGTVAMQRVDNEIDADFVVSLTTTGTTHGLCGTQIQYESSCWNPATKRVVMNVARWVRGAKAFSNDLSTYRQYAINHEVGHALGNNHEGCKENGQPAPVMMQQTFGVANDYVHQLNQVDASNSGAVPADGKVCTPNAFPVAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL2</accession>
    <name>A0A7W7WYL2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="446" mass="49369" checksum="CFD23283EFB52FFA" modified="2021-06-02" version="1">MTSTLDNRIADRVRRADYREWRDKVEGTGGCAKPIRMTGGWQVQHATTGALLDWHGGDVFIPCGNRRESVCPSCSDRYAADAYHLMHAGLAGGSKGVPVTVAGKPRVFATLTAPSFGPVHGRRTTSRGKALPCGCGTWHHPADPALGTPVDPDAYDYVGAVLWNANAGALWARFTTALRRALARAAGLTVREFTHHARVSFAKVAEYQRRGLVHFHAVIRVDGPDGTAASSPSWATAEMLEHAVIAAARASRVEQKHPDGTTTVMRWGAQVDVRTIRPADADRFEDDGAISESRLAGYVAKYATKGTGKSEAADRPIRSRLDIDHLRVSEHHRRMIRTAWDLGGLPAYQALNLRRWAHMLGFRGHFLTKSKHYSTTFTAMRAERRAFRTAELFDRLGHDADTVLLVSHWEYTGSGHRDDAERELAAAIAERTREHRKARYDKEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ40</accession>
    <name>A0A7W7WZ40_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12674" checksum="A6B0FC4154B89D60" modified="2021-06-02" version="1">MYEVQWSRSAAEDLFVKVTSAAVAEELCEVSRTLLDEPPSKDGGPIPVGFWRRGATRSARPDTGTAGERAWDYVLVYRPVRAVRRTYRVIAVLTNAELAAGLAELEPLDTVPLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB9</accession>
    <name>A0A7W7WZB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathionylspermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSP_synth" evidence="1">
        <location>
            <begin position="12"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="387" mass="43521" checksum="7957BAC921F7B9BB" modified="2021-06-02" version="1">MRRETSAPRPGWQRTVSDQGLVFGAPAKDAAGNPRPYWDESVHYVFDMSDVLSLEADVELLHSMCLDAVDNVVTTERYRDFGLPEWLWPAIAESWKRRDPHVYGRFDLRYDGRGPAKLLEYNADTPTSLLEASVVQWNWKTDVFPDDDQWNSIHEKLVERWAEIGAGLPSSELHFTWSGADPSGEDHVTVAYLQETAAEAGLDTVGLAIEEIGWDPLIKRFVDLEESPMATVVKLYPWEWVVDEQFGRYAVETLPATLWVEPLWKMLLSNKALLAVLWEMYPGHPNLLPSFLDDPGLLTEYVRKPRLGREGANIRIVAPGYETETGGVYGKEGFVYQLFDPLPEFDGYRPALGAWVVGDSAAGLGIRETVGLVTDDGAAFVPHRIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZF2</accession>
    <name>A0A7W7WZF2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltranspeptidase/glutathione hydrolase</fullName>
            <ecNumber evidence="1">2.3.2.2</ecNumber>
            <ecNumber evidence="1">3.4.19.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="1"/>
    <dbReference type="EC" id="3.4.19.13" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102953">
        <property type="term" value="F:hypoglycin A gamma-glutamyl transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="594" mass="62706" checksum="6329FFE62B197E93" modified="2021-06-02" version="1">MFTTRPELAGTRGMVASTHWLASGAGMAVLEGGGNAFDAAVTAGFVLQVVEPHLNGPGGEVPVIFAAAGAAPRVLCGQGVAPAGATVAHYRSLGLDLVPGSGLLAATVPGAWDGWLTLLRDYGTKTLREVLDYAIGYARDGFPLVAGASRTIATVADLFRDRWPTSAALWLPGGVPPRAGGVFRNPRLADTWEWLLAAAEAAGSDREAQIEAARRAWSQGFVAAQVDEFCRQSYFDDSGRAHAGVLTGGDMAGWQATYEDPVTADFGEWTVAKAGAWTQGPVLLQQLRLLEGFADRLSYVDGLPTVDTVHLAVECAKLAFADREAWYGDVPDVPLDVLLSREYAQTRRGLITDEASPDLRPGSPNGIAPRLSGHVLSGPFAASGSNGALGEPTVAADTGTVRGDTVHVDVVDRWGNMVSATPSGGWLQSSPTIPSLGFCLGSRAQMFWLDEDLPNTLAPGKRPRITLSPTLALRDGEAALAFGTPGGDQQDQWQLAFWLAHTAGGLDLQAAIDSPMWHTNAFPSSFFPRDWTPGEVLVESRFPGMDELRARGHVVVDAGPWTLGRLSAVARDRRAGLLRAAANPRGGQGYAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZK6</accession>
    <name>A0A7W7WZK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="12998" checksum="88A45807E2980FB7" modified="2021-06-02" version="1">MGSAIVVVDAANVVGSVPDGWWKDRWGATERLRDSLIPLVANGLPGFASGPLEVVLVVEGRVRDLPSVPGVRVVGAPGSGDDTIVSVVRDLRGRRCAVVTADRELRRRVTGLGAEVLGPHSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXN4</accession>
    <name>A0A7W7SXN4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="46"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="413" mass="43503" checksum="F70B74C6FEBE65B4" modified="2021-06-02" version="1">MATSDTTTGTGTSAHPRISKRIGGIAESATLAVDAKAKALKAAGRPVIGFGAGEPDFPTPEAIVAAAQAACADPRNHRYTPAAGLPELRAAIAEKTRRDSGYEVDASQVLVTNGGKQAVYQAFATIVDPGDEVLLPAPFWTTYPEAITLAGGVPVQVTADESTDYLVTVEQLEAARTPRTKVLLLCSPSNPTGSVYSREQLVAIGEWAVEHGLWVITDEIYEHLVYDGTEAVSLPVAVPAIADRTIVLNGVAKTYAMTGWRVGWLIGPADVVKAAANLQSHLTSNVANVSQRAALEAVSGSLEAVHEMRVAFDRRRRTIVELLSAIPGVECPTPKGAFYVYPSVKALIGKELRGTTITDTVQLAALILEHAEVAVVPGEAFGTPGYLRLSYALGDDDLKTGITRLADLLGEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY33</accession>
    <name>A0A7W7SY33_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA reductase-like NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="23"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="30082" checksum="1596C36C8648A7FD" modified="2021-06-02" version="1">MSERVAVAKTYKLYLGGAFPRSESGRSYPVSDPRGTFLANAAQASRKDARDAVSFARKAFPGWSGATAYNRGQVLFRVAEVLEGRREQFVSEVASAEGVPAKKAQGLVDASIDRVVWYAGWTDKIAAVLGGANPVAGPYFSFSVPEPTGVVGVLAPQQSSLLGLVSAVAPVIASGNTAVVVASQDRPLPAVTLSEVLATSDVPGGVVNVLTGLTGEIAPWLASHGDVNALDLTGAPESSRADLERSAAGTVKRVLRHRDEDFTQTPDLVRLRTFVETKTVWHPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY54</accession>
    <name>A0A7W7SY54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAO/AO transport system kinase</fullName>
            <ecNumber evidence="2">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35162" checksum="6A520D75A0C03044" modified="2021-06-02" version="1">MARPVDVEALAAGVRAGNRGVLARAITLVESTRDDHRAAAQRLLVELLPDAGRAHRIGITGVPGVGKSTFVDAFGSMLTAAGHRVAVLAVDPSSTRTGGSILGDKTRMARLAVDPAAFIRPSPTSGTLGGVTRATRETIVLVEAAGYDVVLVETVGVGQSEVAVANMTDCSLFLTLARTGDQLQGIKKGVLELADVIAVNKADGPHELEARKAARELAGALRLLRSSDDAWTPPVLTCSALEGVGLDEVWRRIQAHRDAVAVDERRRRQQVDWTWAMVEDGLLNRLRTTVRDLVADVERQVAGGELTPALAAERLLDAFTSRTRIASLGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYJ3</accession>
    <name>A0A7W7SYJ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000071</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24181" checksum="43C1B3C428CDD4D6" modified="2021-06-02" version="1">MTALLEAVKLRKAFGPTPALDGAGLRVDAGEIVAIMGPSGSGKSTLLHCLAGILKPDAGTVRYRDVELSSMPDAKRSELRRTDFGFVFQFGQLVPELSCLENVALPLRLSGLKRREAQARATEWLERLEVADVAAKRPGETSGGQGQRVAVARALVTGPRVVFADEPTGALDSLNGERVLRLLVTAARETDAAVVLVTHEARVAAYSDREVVVRDGRSREVEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV5</accession>
    <name>A0A7W7SYV5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22961" checksum="7BD666C1B738FB9E" modified="2021-06-02" version="1">MGRRVVGRPRDPAIDRAILDATVAVLREHGYTGFSLEAVVNRAGTTKPSVSRRWPRRQELIIAALVTVVVTPPVPDSGCTRCDLISGVELLAAALLRRMPPGVLAPLVADCAADPELHRHLVDSLIKPVRGAVAATVQRAVERGHLRAGYDAELVVDLLVSVVFQASVFESRFTVDLAANFVDMILQGIAVDFDELVEISRRTPKPHRHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYY3</accession>
    <name>A0A7W7SYY3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20213" checksum="E5C79E6787749864" modified="2021-06-02" version="1">MTLFEDLSPLDLLSLSRALLSEEFAAAELTPFDWLGIVEMLEGSLVDKCQDLTPREWSVCVLALARSHASAVDSGILDDREVLVRRLNLGAVLTRGVPVSREFEILNPDALIAELFRKLPMTIDEARRMSADWRSLEISQIRVLRSVKNLVTPAVQLARVAPGTAWLPMLRLWADILPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYY6</accession>
    <name>A0A7W7SYY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15170" checksum="AE2B64101A6F2E59" modified="2021-06-02" version="1">MSVIEVDPAVKAAFDERLEAARRANAQVTGALQADRERLAAEAREREARLVADRERLREKAEKVVAEGDKASQRQSQWAPAQQRDGELAFGPEEEDDVPPAPAPAPAPVSAGVPLPPATPRRRSAPVEDDDDLSGQSWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ13</accession>
    <name>A0A7W7SZ13_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phage shock protein PspC (Stress-responsive transcriptional regulator)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2154" evidence="9">
        <location>
            <begin position="296"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="42793" checksum="BC5EC4DE49DE19E7" modified="2021-06-02" version="1">MSGNLSTAGVEETLKDFWASRPRRPQAGRKIAGVAAGIGERYRIDPVIVRIAFVAMALCNGAGFLIYLLGWLWLAQSDDQVSPAEALLGRGRSSTPTPLTILLGLAVFPATGFFVDGGFTMVAGVLLSVGGVYLLHRNRGALNRPAPTPEVTMDQSADGRTDRHATVPPTATPSGPPAWDPLGAAPFAWDLPEPTPAVVYEPPPPPVRRRRSRVGKVTFGLVMLVVAGSAIASDSAAWFTAPHVLGLVVAVLGLGLVVGAFRGGARGLIWLVVPLALAGVGMTSIDGSSFGSERIGDYRDTPTSIEQVQPRYDTNAGEVVVDLRELPTTGSVRTTVEVGVGTAQVFVPENADVTVTCAAELGSFDCLDHKQDGADREQRVVDSGADGPGGLKIELDVRAGVGEVMVTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ56</accession>
    <name>A0A7W7SZ56_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase-like lactoylglutathione lyase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14920" checksum="619A017C932B8B5C" modified="2021-06-02" version="1">MYVPVTGIPVDDQDKALAFYTEVLGFVKKQDVPVGDAKWLTVVSPEAPDGVEILLEPDGNPGIRIGDEPAARVYKKTLYDAGMPYTMLGTKDLQKDYERMTAHGVRFTLEPTKTPFGAQAVFDDTCGNLIVLVQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS1</accession>
    <name>A0A7W7SZS1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="23811" checksum="D3A89FA5AAA4B40E" modified="2021-06-02" version="1">MTDISVRWNDYQVEKRDWLAGEHGTGPGDNPSVVLDVSLFTQNIHYPNGYIPSGTPLAKVTATGLYGPYSVTDEVQTITEGGSGLTSFTLTLSGQTTGSIAAAATADTVKAAIEALSNVGAGNVAVTGNAGGPYTVTFTGALADTNVAQMTATPTGGTGTVTIATTTGGGTEGTGGLETCAGLLFGFATVVRGTTTLAKVGGALFVHGFVRRSRLPFTLDTNGQNDLKLIHFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E6</accession>
    <name>A0A7W7T0E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="20647" checksum="A012FFC6C605BF61" modified="2021-06-02" version="1">MRFDFAQLPAFLVACAVVILTPGVDAFLLLRTSMRSGVRSGLLALAGIHTAAAIQVGLVVSGLGVVIARYPAVLTALRWIGAAYLLYLAVSIARGLVAGGTDGDGGRVAARPFRAGFLTNITNPKMLLFSLAFLPQFIGTGDPAWQLGLLAAVFLAAAALWESVIVLTAARMAGALGRFTTALDVVCAAVFVTMSVGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G1</accession>
    <name>A0A7W7T0G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17583" checksum="917798E865009213" modified="2021-06-02" version="1">MVEDSGVDELLRQWAAERSDDAELREVNRIKDAWLAEAPQSPGIPVQRATGGARGVMRVESADPAYVVAMRKRAPEVPEGLLAAAASYWQLVGDLAEAEAWWDAGISPLDQRALDYRAAGLTPADLGRRLGPMTVLQHLRRGSAAAWCVARLQRQRRDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0J2</accession>
    <name>A0A7W7T0J2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconokinase</fullName>
            <ecNumber evidence="2">2.7.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.45" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008673">
        <property type="term" value="F:2-dehydro-3-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="33600" checksum="49671D84C8A5A355" modified="2021-06-02" version="1">MRFDPAGGVVCLGETMAVLVPAEPGPVRSARTWTRAIGGAESNVAMHLARLGVRSRWVGAVGDDALGGAVLDFVSGAGVDVSAVHVDPDRPTGLYVKEADPTGTRTRYYRRGSAASAMGVDTLDRVKLDDVALIHVTGITAALSDGCLDLLRAVLARPRPVPVSFDLNWRPALWRDRDPAVLRDLADAADIVLVGSDEAHAVWGVDGVDDLRALLPSPTTLVIKHGERGATVVEDGAAVFHQALRVDVVEPVGAGDAFAAGYLAAHLSGETPTRRLRAGHLQAASALLTSEDVGEPLPADVTVPLLDADPATWAAAHLGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N5</accession>
    <name>A0A7W7T0N5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">F4559_001738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5031661074" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031661073" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="186"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="39407" checksum="6692C3002089B266" modified="2021-06-02" version="1">MNRSKGVTGPKGFKAAGVAAGIKESGAPDLTLVVNEGPGQAAAGVFTTNQVKAAPVLWTQQVIKERRLRAVVLNSGGANACTGPEGFQDTHATAEKVADVLGVGAIEIAVCSTGLIGERLPMDRVLTGVEKAAAGLADTDEAGLAAATAVMTTDSHPKQSHAAHAAGWSVGGFAKGAGMLAPNMATMLSVLTTDAVVDGDTLDAALREVTARTYDTLDVDGGTSTNDTVLVLASGASGVTPTKAELVEVLASVAGDLVKQLQGDAEGVTKEVAITVTGARTDADAIVVARTVAEDNLVKTALFGSDPNWGRIAMAVGRAAAEVDQFKLGITVNGVTLFADGHKAADRSEADLSGRDVTVEIALGLGEGTATVLTTDLSHGYVEENSAYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T102</accession>
    <name>A0A7W7T102_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">F4559_001948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="181"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="39918" checksum="C7B6F85CB937C2EA" modified="2021-06-02" version="1">MGDDDRIDDRGVVMGEPVRIRVAAERPYDVIVGRGLLGDLVATLSGTAKAAIIHTATLGETAEAVRAELASAGIDAHRVEVPDAEDGKDLRVAGYCWDVFGQIGLSRTDAVIGLGGGAVTDLAGFVASTWMRGVKLVNVPTTLLGMVDAAVGGKTGINTDAGKNLVGTFYEPTAVLVDLATLETLPRNELVAGMAEVVKGGFIADPVILDLIEADPAAALDPAGDVLGELVRRKIQVKADVVSSDLRESSLREILNYGHTLGHAIERRERYRWRHGAAISVGLVFAAELARLAGRLDDATADRHRGVLTALGLPTSYDPDALPQLLEGMRSDKKNRAGVLRFVVLDGLAKPGRLEGPDPSLIAAAYSAVATEGRAGGSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T152</accession>
    <name>A0A7W7T152_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rieske Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="13187" checksum="178FE79F373B8A69" modified="2021-06-02" version="1">MDRRTLLCGLLALTACGTGTAARRPGLGGARPGDRLAGLADVPVGSGALLDVGTDGQLLFVRPDADVVRAFDPTCPHQGTVVNPPVKGVIVCPTHRSEFDPATGGRLAGLAPRGLTEVPVTVAGDDVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H4</accession>
    <name>A0A7W7T1H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21775" checksum="FDB5F3E964993795" modified="2021-06-02" version="1">MLTTAAAAALALSAIVPVDSPIDSVPDYVTVQVVAVNGSGCPAGTAAVAASDDRTAFTVTYSQFLAQAGDSTSPTDFRKNCQLGLQLNYPQGFTFGVAQADYRGFAHLQSGATGLEQGNYYFQGTSPTARKSHSLRGPFSDNWQFTDSTEWSAIVYAPCGERKLLNVNAELRVNAGSSKGTSFIAMDSTDGRISTRYHFSWKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K4</accession>
    <name>A0A7W7T1K4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="525"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="825" mass="90106" checksum="29F034894B940338" modified="2021-06-02" version="1">MKQKSTTETNYKTIRSRLTGVVVVPSIVLLVMWALFSSYTVFDGIYLRAVAAGVEDASIPALQTFAAIQKERELSMTTLSQPGAVVSDLIAQHQATDRAVEEMRKAFADVASQAPQEIVDKIGALNALLDQLPQKRDQLESNRVSKTDVYDYYNSVLDAGDALFSVQSRVVPDAESMTNAVTAADYFRAADWMSRATSLASGALAAGSFGTEEHVEFATLVGAYHSSFTTLEPYALPKAREHYRFMVEGDAWKRLVELENRLIGNGSRPISSVTLQEWQSVSGPISTELTALVEEQSTSAVSVTMARGESKFRTVLIGSLIALLAVIIGILIAIRTSNRLVNRALITRLTALKKDSLTLAHERLPDIVDRLREGKHVDVEVEVPPLDYGSDEIGQVADAFNAAQYTAVAAAVKESQAREGVNRVFLDIAHRNQGLVHRQLKILDKLEREEENPEQLDALFQLDHLATRARRNAENLIILAGEQPGRQWRKPVRLLDVLRAAVAETEQYVRVKVNPVPDTALVGAAVADTIHLIAELVDNATAFSSPRSQVQVHASEVPQGVVVEIEDHGLGINPEDREQHNAMLADPPEFDAMRLRGESRLGLFVVARLAARRGIHVELRESPYGGTLALVVVPSAIVAGPNAAVEPAETRELPRRTLPDDHPIPEQVDEPVQDARFPDTSRELEGFWAQAEAAANQRPAGVDPHPAPERVSGNVDLSAPPGLELSGELDLSSHSGDLALPQRKRPPAGEPPPATPGAAVDRPELPRRRRQQNLAPQLARNDFHPSPEPLAEVDPVKSAEKSRKGLSAFQRGTRDARGTSDDRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S3</accession>
    <name>A0A7W7T1S3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type multidrug transport system fused ATPase/permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="50"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="377"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="414"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="625" mass="66909" checksum="60F1A230FC7A8AB8" modified="2021-06-02" version="1">MDMETTAWTSLYNTITAQNDRRPFSLAGLRRIWAFTSTRRGRLFRYLGVSVIVAVLAVATPVLAGRVVDAIVSGEPYATVLGLSASIAVLAVLEAGLGLVSRWLSASLGEDLILALRTAVFDHVQRMPVAFFTRTRTGALVSRLNNDVLGAQRAFSDVLSGVVGNLVTLALTFVVMVGLSWQITLLALVLLPLFVVPARLMGARLARLRREAAAHNATMGTQMTERFSAPGATLVKLFGSPDRESDEFAVRARRVRDIGLRTAMVQTVFITSLTLVSSLALALVYGLGGFYALAGSLEPGAVVALALLLTRLYAPLTALAGARVEVMSALVSFERVFEVLDLEPLITYRDDARTVPDGPVSVEFDHVRFGYPAADKVSLASLEEVASLDTRAGVEVLHDVSFTAAPGQVVAVVGSSGAGKSTLASLLPRLYDVDSGAIRLSGVDVRDLSAATLRSTLGMVTQDGHLFHTTVRENLLLARPAAGEDDLWESLRRARLDDLIRTLPDGLDTVVGERGYRLSGGERQRLTIARLLLAGPRVVILDEATAHLDSTSEAAVQEALAEALAGRTAIVIAHRLSTIRAADQILVVEDGHIVERGTHTDLLAADGRYARLYRTQFDEAAVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T7</accession>
    <name>A0A7W7T1T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="27763" checksum="9D20D671B9C3971A" modified="2021-06-02" version="1">MSARTTLDADLPEGGGVRLVVDGPRATITLDRPDVLNAQTPSTWAALREIGAQLDPDVRVVVVRGSGRAFSAGLDRRVLTGEPIPGEPGFADIVRHGPDAGAALIAGFQEGFRWLRDPARVTVAAVRGHAIGAGFQLALACDLRVVADDVRFRMAETALGLVPDLGGTLPLVRLVGYARAVELCLTGREVGAEEASRIGLANAVVSPEGLDAAVDDLVARLLAAPADAVVETVALLASAADGATEQEQLYAERAAQLRRLTDLAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U1</accession>
    <name>A0A7W7T1U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lrp/AsnC family leucine-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16326" checksum="25E3E84FEA48CAD1" modified="2021-06-02" version="1">MTNLEPTDRAILRELAADGRCSFTDLAERVGLSVSAVHQRVRRLEQRGVVKGYAARLDGDEIGLPLTAFISLTPIDPAAPDDYPKRLEHLPQIEACYSVAGDASYVLRVRVASPTGLEELLRQIREAANVSTRTTVVLSTPYEDRPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z9</accession>
    <name>A0A7W7T1Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type branched-subunit amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="521" mass="56008" checksum="E577721ED8B2BEFC" modified="2021-06-02" version="1">MTFTPRDTPRGLRRRRVRLTALLVAVLLVLGVGGWLGSRWLDARGARCHGLDSTEGEGYALSLAGDQCIGWIVEEDHAFGSTDERVNAVITAVVKENQRVHDQAGRTGGTPYVRIAVLMPMTSREGSAMRDNEVLHALQGAYAAQRQANQGRSVLGDPTPQVQLVLANEGRDQEHWAPVVRQLGALRGGDHPLVAVTGMGISIDATKQAADELGRLQIPAVGAVLTADDMTSPLLFKTTPSNAQYTLALKAFLDGSPKRTEPAKRTGYLLFDRNQDKYVQSLRAAFTTTFGEEYGLKGRSGGFNGSASPNGTPLLLSELVQDVCAAKPDVLFFAGRGRDIDDLMQALALRTGCREPDDPLIVATGATGISIEPQALDEANAILLNAAATDTRAWLAGEPGTPKHFGEFRTWFAGLGFAEDDLRDGYAIMHHDAVAATVWAARRAARSIEAVEGQRLKNEDVGQHLYSSTTDLVPGASGEIYFAENPPNDRWPIGKPIPVLKSGPRSDTLTTGPVYLTQPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T254</accession>
    <name>A0A7W7T254_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="71"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23644" checksum="B75AB98677E6E7CF" modified="2021-06-02" version="1">MFSHFDRPQRRHHRDRGFGDPRGGFGGGFGPFRPPMPPQPPEPPEFFGRGGPGRGGRRGGRQRKGNVRVAVLALLAEREMHGYEMIQEIGRRTDGLWRPSPGSVYPTLQLLADEGLVSSSEEAGGKKLFSLTETGRAEAAKFEGAPPWQQVTDDIDDHAMKLHTASGHLASALRQMAHAGTREQKTRAIEIVNEARRQLYAILGEIDVEEDTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T270</accession>
    <name>A0A7W7T270_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030602525" evidence="2">
        <location>
            <begin position="31"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="51974" checksum="8F16E332F5F5A3CC" modified="2021-06-02" version="1">MWNSRIRRASTAVISAALIVLGGLPVAAHASPADETESAEVYVIEDGETARAVASAADPGAAAKAAGIAPLPQVGDEAVRSEVAVSAAEESYVVDSERFDRGAKPEDPYQYADRDQCRSNEKSDRYQGWIKNRYSYCKVELVYVPVVSCSIFPPRCAVRDEYLAWHTVVGEGKIGSYRADSFDRWARFTIHVSPVTIIGRFGTSGARLAVGMECEGRYRDPVPRTPRAACRTGEENGRDDTVPGWRANGEATIELVSEADKPAAERTAQIAIGIFKPRINLSWQPLGRRNWRMPEGGMRFDSAWYASQATAEQLGSVFDRARSGMSYRLGDPKVAGLAAHIDDARRNPDGTLPPASGKRLPGATADDPIRRLARRAGQAQADRYQDNIDLTRNGYCRTGMPPKPPTGSFDCDEYPFASTCEGAGRAKHEGAQYKDAWSVRWVDSGQNQEGGRRLGRWYANDRLLDTDPFFVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T298</accession>
    <name>A0A7W7T298_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ORF">F4559_001394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="36097" checksum="08511316643C278D" modified="2021-06-02" version="1">MNVDIAALRAIERDKDIPFDTVLEAIETALLTAYKHTDGHHSHSRVEIDRKTGVVRVLAQEIGQDGTVLEEWDDTPEGFGRIAATTARQVILQRLRDAEHERTFGEFSAKEGEIVGGVVQRDARANARGMVVVQVGDTEGVLPPAEQVPGESYEHGSRIKCYVVGVSRSARGPQITLSRTHPNLVRRLFALEVPEIADGTVEIPAVAREAGHRSKIAVRSTVSGVNAKGACIGPMGARVRNVMSELAGEKIDIIDHSDDPATFVGNALSPAKVVSVRVLDERAKTARVVVPDFQLSLAIGKEGQNARLAARLTGWRIDIRSDAEAASAGAATSGSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J3</accession>
    <name>A0A7W7T2J3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="74"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="37593" checksum="4F0EFD374BB788C0" modified="2021-06-02" version="1">MFSVPWPTRRPPFGPVGYHWLVLDHAPDLAALFPELSDDTLVVDYDDAEDPVLRRADGSSIDTWRENYPYQERMSREEYDLLKRLLQIELLKLQYWIKDNGGRMVVVFEGRDAAGKGGTIKRFTEHLNPRGARVVALGKPTEREQGEWYFQRYVDHLPTAGEIVLFDRSWYNRAGVERVMGYCTDEQYHRFMHQAPRFEQMLVDDGITLVKLWFSVSQAEQRTRFLIRQVDPVRQWKLSPNDLESLDRWTAYTRAKVAMFRETDTTSAPWTVVKSNDKKRARVEAMRSVLARFDYADKDHEVVGAPDPRVIGPAATLLEEGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J9</accession>
    <name>A0A7W7T2J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-beta hydrolase superfamily lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="29257" checksum="82723646365CF845" modified="2021-06-02" version="1">MTAPDTIVLIHGFWVTPRSWEHWIAHYESKGFRVLAPAYPGLEVEVEALRADPTPIAELTVPRIIDHLSSVIDALDAPPILIGHSAGGAFTQILLDRGRGAVGVALNSAPTEGVRVVPFSQVKSTFAVFKNPANRHRAVPISFAQWNYAFTNTFTEDESRALYERYAIPVNGGIVWGGVLANFQPGHQDTWVDYHNDARAPLLFVAGGEDHIMPPAVQRSNAGHYRSDTVTEIEERPGFAHLLPAQPGWQEIADHVLDWALRHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M4</accession>
    <name>A0A7W7T2M4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative peroxidase-related enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20458" checksum="0B182B55D70D27E4" modified="2021-06-02" version="1">MAFIDLVSDDADKPAEVEAVFAAAREGYGFVPNVLRALAHCPDLLTTFAPFWAQVYRSPTIGGRLRALSALGTAQAQSCTYCVAHMSASARRVGMSEQEVSAVGDPHVEQRVFHDERETLVLEVAAALTRDPDGVTDDLRARLRRHLTDAEIVNVVVAIGLYNLTSRFLKALDVEVEDVFTATPTTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X1</accession>
    <name>A0A7W7T2X1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040547">
        <property type="entry name" value="CdiI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18616">
        <property type="entry name" value="CdiI_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15726" checksum="0DCCE7809837C032" modified="2021-06-02" version="1">MRARRVDDSSSIEQIENDRWGPAPPGATRLVRTIHELRGKSLRALTPEDLRMLLGQHEGVALLVPIALTALEHDPLLEGDLHPGDVVVSVLHAPVSYWRAHPDQLARLERVLAVVEHVPAVDAPSDAVVAARIESFRARLRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I1</accession>
    <name>A0A7W7T3I1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12557" checksum="2F94ADDAF4E1B254" modified="2021-06-02" version="1">MDEADALIGLVRVESPSAAPVLLDVHLSGDPYAQGSDVGITVDRGVIRYSGPEWPHGVVSAGNASTDGEPRSYFYMGHGREFPANSEVPIDVVRQAVKEFMESSGARPTCVRWQDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T424</accession>
    <name>A0A7W7T424_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YjbI with pentapeptide repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23417" checksum="EA472FB3CAA81E41" modified="2021-06-02" version="1">MDFETVAGKTVQRANIDPDDLTEVDAAFRGEFDFDSVHIEKGAQVDTSGEGAIVRSLVGPVDLSGSRLAPVDLSDVRFAGAVLANTELTDTTARRVEFTRCQGIGLRVVFTMAADLIAEDCRFDFASMRFDKIKNAAVFRRCSFREATFGGDLSNIVFDDCDLVDVEFAAIRAVGCDFTSSRLVGGNGLSTLRGARIDPVQAGTLGVQFAREAGLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T425</accession>
    <name>A0A7W7T425_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="13771" checksum="4C8ABEF9DF59C75E" modified="2021-06-02" version="1">MVTAVVGAFLPWLRSGTTTRSSYEVLALRGFAGLEGVAGEVIRLFWVGLIPLAVLCVVLFVLRARRIAAFLTLAFGTITGTVAALACVQGGDESSLVGITTTGPVATLGGAVLGIVGAIAVLTAKTRTAVSSPGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T455</accession>
    <name>A0A7W7T455_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="376" mass="38892" checksum="CD21CF248AD0DE15" modified="2021-06-02" version="1">MAEEKTKAGGVEITVGEKATSQKVAEAVPFYGNYLKTTEALGKAQKDGGAEVTGLASEATGLLGAVGTSAFGIATDPIGWLVGQGLNFLISVVQPLEDAIHFVSGDGPALSQAAENFNNIAKGVAELRKKFDEDLKNSVTGWGGPASEAAGTKLGEFANGIDGVAGQAGELARLLQISSMVMTIIEDFIKAILTELITWLIMIWIPALAAAVPSFGASTAAAGAATGVRVASTGSRVARIVARLKQFLAKILDFLRGLAGRIGNVKAAFQRSMANKQISHVVAAGIQDGKKPGHRSPIVQVWGERGVLGERVRDGFGRSVAGSAFDAAQAQLGIGTGTNAGIDKPIRNFGSGQKAAAYDDTGTDQYKEKTEGHLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A0</accession>
    <name>A0A7W7T4A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="17784" checksum="34A0987CFD0125DF" modified="2021-06-02" version="1">MNGQTEQVDDLRLVALPTAINVADLFVRFSLGEWRLRTMQDEAAQTARRLVGAAVDVADPKKPGLLLIRLRLSGGHLAVEVEGGRVALPPELTGGRAGLVALTAGGHLAWCELPLPSGMNAAAVPLPRREPRRSPAAEAMGDEPAVDPEVIQRILHSLGGSTERRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B1</accession>
    <name>A0A7W7T4B1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="22264" checksum="87DE63F04F72DC7E" modified="2021-06-02" version="1">MRVREVMTREAVTVGADTLVRDAGALLAARGFTMLPVVDGFGALVGVFTEADALAHRLPVDPRGLVHGMPPRQRTAPPHTVGGLVSTPPVVATPHADVDEVARRMVEHGARSVPVVDGTRLVGVITLQDLLRAVTRDDRVVAAEVRRRLRRYGGRDRWRVDAVDGRVSIVDELADVGDRHVAAVLAGAVPGVVAVDFPQAGLADAVDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B4</accession>
    <name>A0A7W7T4B4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15567" checksum="9136C9D07E3E7F55" modified="2021-06-02" version="1">MTAGRRAVGHTRDAGWQIGVSKTVEHPAETVWEFVTSPAGIAIWLGAGVTVLDERGTPYETADGTRGETRSYRTMDRLRLTWQPPDWDHETTLQLTVRATGPGRARLGVHQERLADATEREQQREHWQGVISALAAALAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B7</accession>
    <name>A0A7W7T4B7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="25287" checksum="D82BDFC4646C34D5" modified="2021-06-02" version="1">MTTATLDVSARNTASFWEALAWARGGEVVRRPGFAATSWSGLSRIVVLRPELSPDDRAELERLLAAAEGAVRVQDVYRTLDLSDLGYESRSLPLMVRDPAPLPTPSVEITRVATAADLAVAERVIIEGFPVPERPGLLLPGPLLERPDVDVLIAWRDGEAAGACFVVDDGVAGLYWMTTSPAHRSRGVGRALMYAVLDRPAPVVLTASKAGRPLYESLGFRTVGDAAWWGDEPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W1</accession>
    <name>A0A7W7T4W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="41" mass="4308" checksum="18C6D492DA039E90" modified="2021-06-02" version="1">MGQHEDKTDQDRKDPPHKPQGSGSQGAPDPDKPDGKHGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X0</accession>
    <name>A0A7W7T4X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation-transporting ATPase F</fullName>
            <ecNumber evidence="12">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_003431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4966072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="814" mass="85717" checksum="491AFC157CD3E3F1" modified="2021-06-02" version="1">MDEVVRLARTDAAAGLPARVARQRLADLGPNALPARRGPGAVRRLLGQFTNPLIHVLLGAAVLTFALGEPVDASVVLAVVLVNAIIGHLQEGRAERALDALVAMVTTTAVVVRDGTAARVDSADLVPGDLVVLEEGDRVPADLRLVRTRELRVDESSLTGESDPVAKDPAPVPTTAPTADRTNMAYSSTLVTGGGGRGVVVATGADTEIGRVHRLVGTTGSVRTPLTRKLAKFSRLLTWVILGLAVVAAIVGVLRGEPLGAMVTAAVALAVGAIPEGLPAAVTITLAIGVARMARRHAVVRRLPAVETLGSTTLICTDKTGTLTANAMTVREVVADGVRWRVDGVGYSPLGPHPAAPRAVRECLLAGLACNDADVVERDGRWVAVGDPTEAALVVAARKAGITDVPDRVDELPFTSRRRFMATRHRGGVVYLKGAVERIAGFTGTVDHAEAERLAGQGLRVLAFARAHVPEELELTEDVLRGAEYLGLQAMHDPPRPEALEAVRACREAGIEVRMITGDHPATARAVADRFGLPDDAVHARVSPEEKLRLVERFQAAGHVVAMTGDGVNDAPALRRADIGVAMGRGGTEVAKEAADMVLTDDDFATVRAAVEEGRSVFDNLRRFIVWTLPTNMAEGLVILTAILLGTALPILPVQILWINMTTAVALGLTLAFEPRDPDAMRRPPLPPSLPLLTGALVRRVLLVSLLLVAGSFAAFEFAGGTVEHARTVAVNVFVAAQIAYLVNCRSPRARLRANPWLPAGIALTVVLQLLLTYAPFMNALFHTAPIGLSSWAVVVGLAALAYSVVELAEVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J0</accession>
    <name>A0A7W7T5J0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35987" checksum="9E8B0CA1BF149670" modified="2021-06-02" version="1">MTGALGLTAEEVAEVLGAAVLAPSVHNTQPWRFRLLPDRIELHPDPDRVLPATDPEGRELRLSCGAALFNLRLALLGLGVRPLVTLVPGDDAPGALAVVRRGGRRAPDDDTRRLLDAVPLRRTNRLPFAPGGVPVDQRRALLRAAERERAWLHLVGPTEIDRVRELAVKAHRLQLEDAEVRGELSEWSATRPCGDGVPHASAGLRPAPDDGWPMRDFRGAERAADEAYEPDPLVAVLCSFYEGPAAELQSGQALQRVLLTATALGLAASFLSQVIEVRPVREELRRSLGGTLVPQTVLRLGVGATVPERPRRDVADLVLPVGQRVPKFWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N4</accession>
    <name>A0A7W7T5N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="20798" checksum="541C41B58907A150" modified="2021-06-02" version="1">MEKLGLRERKKAATRQAIHEAAVHLALELGPERVTVDLVADAAQVSRRTFSNYFANKEEAIFHADHTRLRRLVALVAARPAGESARAALAGAARELVAESPHSDPVWVAQRRLLRGHPSLAAHQVAAYAVFERDLTSAVATRLPDPDPLRSRVLAVTFLAALRAAAHVWLDHPDRSFGELVEEALDCLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T636</accession>
    <name>A0A7W7T636_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydroanticapsin dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.385</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.385" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="23527" checksum="DF3806F66364C662" modified="2021-06-02" version="1">MLLSLTDRKVLVTGGASGIGRACVEAFRAEGARVVALDRAGGADVVRADVTDESSLAAGVAEAVALLGGLDVVVGCAGISGPVGTPLVETSAADLAAVIAVNVTGQLLLAKHTYPHLSDGGSIVFLASDSAFVSVPGMVPYCASKGAVVSLTRALAVEFDRVRVNCVCPSIVDTPMARGDLGDEALDDAAFPVQTAEEVARQVLFLATPLSRAVNGQALLADFGYSARSAFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T696</accession>
    <name>A0A7W7T696_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator DesR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21614" checksum="E093068BE90B5617" modified="2021-06-02" version="1">MIKVVLAEDVQMVRGALVALLDLEPDIEVVASVATGDEIVPVVTREKPDVAVLDIDLPGLDGLSAAALIHQTVPQTRTLILTSLGRPGTLRRALTARVNGFILKDAPIDRLADAIRGVAVGRRVIESQLALAAWEGDECPLTPRELEVLRLAADGADAMEIARALFLSVGTIRNYLTTVTMKLEARNRVDAIRIARTAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A9</accession>
    <name>A0A7W7T6A9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13537" checksum="3B2DB8F54BFF8E6C" modified="2021-06-02" version="1">MATVELTAENFDEVIGGSDLVLVDFWASWCGPCRQFAPVFEKSAQKHDDIVFGKVDTEAQQQLAAAFQIRSIPTLMIVRDGVVLYAQPGALPETALEDLIEQARQVDMEKIRKEVAEAERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C8</accession>
    <name>A0A7W7T6C8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="15"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="549" mass="62438" checksum="A8EE7AB5ECDDE6F1" modified="2021-06-02" version="1">MSQADDWFKSAVFYEVLVRAFSDSDGDGFGDLRGLASRLDYLQWLGVDCLWLPPFYDSPLRDGGYDIRDFHTVLPEFGTVEDFVHLLEEAHRRGIRVITDLVLNHTSDAHHWFQESRRDPDGPYGDFYVWSDDDTKYADARIIFVDTETSNWTFDPVRKQFYWHRFFSHQPDLNFDNPAVRDAMLDVMRFWLDLGIDGFRLDAVPYLFEREGTSGENLPETHDFLRLCRKVVDDEYPGRVLLAEANQWPTDVVDYFGDPDVGGDECHMAFHFPLMPRLFMAVRQETREPISEILAATPEIPSGTQWGIFLRNHDELTLEMVSDEERAFMYAEYAKDPRMKANIGIRRRLAPLLDNDRDRQELFTAMLLSLPGSPVLYYGDEIGMGDNIWLPDRDGVRTPMQWTPDRNAGFGTGDPGRLYLPVVSDAVYGYQATNVEAQLGSPGSLLHWTKRMIEVRRGHPAFGLGGFRELRPDNVAVLAYLREHGDDVVLCVNNLSARPQPVDLDLGGFAGRTVTELTGGVDFPVVGAAPYRITVPGHGFFWFAIGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6H4</accession>
    <name>A0A7W7T6H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32766" checksum="6E04DD930FAB2DC4" modified="2021-06-02" version="1">MLKEFVEWFDDQLMRRGVSGIFHAVLGILSLGAVASAVFGGTAVKVAAVLVAVIVLLAAMALLASGRKEQVLGRLRDDLLIGSLVDAVTGRSGNARITMWEDVAQIDSDGNVVETVTVFARAETGDVRFYRLRVGPGWNQPKRQRAKVVCEVVGVRPDGGDGPRYDLRCRRLVDGRLETVVTLPDTVKVGQRFRVRFKYSWPGMCEPLMVWGQPEDFRLRFAHAVEGVRYTIVLPAGREVRFESIGFDGGDSAYAVEVDRDPAGAVSLSLTARNVPAKHTFGTRLDLDRTTRPVGRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K3</accession>
    <name>A0A7W7T6K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM superfamily enzyme YgiQ (UPF0313 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="128"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="376" mass="42583" checksum="545273384B65586B" modified="2021-06-02" version="1">MTAWDAHLFARPEPVGRFDLALVGVGQFEGLARGLDLVRRLRNRASRTIVFGQYAQMNSAAFLDEADGVLFEEPERVARELVSGELANVPALRGSWGMAPRPPHRRLAYTKPARELFPSLVHYHAHHTRYGLMGNIEATRGCHHRCTYCSVYGAYDGGIAPIEAEAVVRDALQLADEGVRHFCFIDAEFFNSRRLGIQVAERIVAEVGPCTFEMTTRVDHILDYTAELERFVELGLRRVTSALEFPSDRILRIFDKGIDLGDTRRAIAEADRLGFALNPTFIPFTPWVSYEELLTFEDFLAETGLERTTDPTALQTRLLLFKGSPLLGSPWLDGVDTVDRGFFVEWTHPDRRVEELWLRRRQDAEDVGKVRCCVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M8</accession>
    <name>A0A7W7T6M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase-like lactoylglutathione lyase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19547" checksum="35F76B0D5A595D1F" modified="2021-06-02" version="1">MGGIPGAQAVHHFACTVPDLDQAVDFFVDVVGAELAYRLGPVHDPGGDWMARKLGVDAAAVAHIAMLRLGPVTNLELFEYSARDQRKALPRNSDWGGHHLAIHVADVDVAAAYLREQPGVTVFGDPETLTDGPIAGDRWVYFTTPWGMQLELINLPAGLPFERDTPARLYAPDAPWRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T732</accession>
    <name>A0A7W7T732_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nicotinamide mononucleotide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36122">
        <property type="entry name" value="PTHR36122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01528">
        <property type="entry name" value="NMN_trans_PnuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23590" checksum="CF47FF2AF46D5BF1" modified="2021-06-02" version="1">MHVLLDQGFTAFGQKVSYAEFIGQVFALLVVFFAQRRSLWTWPVQLVSVTLLFMVYVSAHLGGTAARQVVIAAITLYGWWAWTRRRDPVFGVVVRKGTTRERLVTAAAFVVGTVVFALVLDAFDASWSPWPDAALFVGTVLAFTLQGLGLVEFWVVWLVVDAIGVPLQIGSGLYFSAAVYVVFAALVISGYLNWTRAAARVPRADDAVRIGSADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T740</accession>
    <name>A0A7W7T740_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="45"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23496" checksum="937B9B17620E0807" modified="2021-06-02" version="1">MARKTVLKLMNTLGLVCKVRRPRRHRSWQGQTGTTAGNLLNREFGASSPDTKWVTDVTEFRVGDRKIYLSPVIDLFDRSVIAYSCGLSPSLELTNSSLRAAIATLPAAARPLVHSDQGFHYQHVTWRRLLADAGLTQSMSRRGNCLDNAVAENFFGHLKEELFHHTTFDTVEEFTAALHEYIDWYNTTRISTTLKGLSPVQYRAQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V8</accession>
    <name>A0A7W7T7V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent helicase YprA (DUF1998 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="46" mass="5098" checksum="BFCDEF78439B7872" modified="2021-06-02" version="1">MNALVNDQEDRVKAACEQLGLRHGVYTGGTPQTCGTRCRMLRRTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T849</accession>
    <name>A0A7W7T849_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csrA</name>
        <name evidence="3" type="ORF">F4559_005706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8547" checksum="7BE06237C5F7C58B" modified="2021-06-02" version="1">MLVLTRRSGESVRIGDEVTVTVLDVRGDVVRIGVAAPRSIAVHRDEVYRELKKANEQAVADEAATAALTEALRFRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B6</accession>
    <name>A0A7W7T8B6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18450" checksum="B2F5D83C9C4A8EEA" modified="2021-06-02" version="1">MTDPHRMIEDYESHTSALLERAEEAKARIAELTGSATSSDGAVSVSVSAGGALVSLSFGSKADDMPKERLAALVVSTAKRAQAQAVGRIATIMAPVVGDNSDAMRFVQEQIPPIDVSDEHTGEPQPQFVVNEEQQDAAATRQTPAARPVRRPVKDDDTDYDQRGVFKKDGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G2</accession>
    <name>A0A7W7T8G2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="36546" checksum="0B2638C7F4895988" modified="2021-06-02" version="1">MSLQGRITAGYRTDLMLVLLGTWFSIGLFLDAWAHANVPELETFFTPWHAVFYSGFAATAAWISWVVWRNVQRGHSWRDAVPAGYGPAVLALPLFALSGVGDYLWHTFLGIERGLDILYSPTHLGLITSMIIILNTPLRTAWVKLGDRPSPREFLPAALSLAFTTSLVLLFAGFADATVWTSADVVRAFSFPKGNETLFTLTLAASVAVTNIVLIVPLLVIARRFRPPLGLATLVYTVCMLLSTAIAGYANISTAIGFVLAGVVADVLLWWLKPSGDAPGRLRLFAALSSFATWAIYFAVAGITAGGMPSVTEMWTGAPVLAALHGLLLAALLVPTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I2</accession>
    <name>A0A7W7T8I2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28142" checksum="57BC6C5E0D1150BB" modified="2021-06-02" version="1">MTNATAAPVTAHRAGRVPRQRGGGVDEVKYRLIADHLIAAMNRGEHPVGSTLPTLQQLMERFGVARGTARAAVAVLVAEGLATPRQGYGTVVSATRTRSDQAKPRTLPSGIPHPKVVLSGWTAATPDIASRLGIPAGTLVVHRIRHHHTGTRVTRIEQQWLPESIATAIEERTGHDISDRDDTPQPDLTPLLRHAGFDPVVATVQVGARLPDHAEADTMRLSTDTPLVVVDRITHSSSGSPVEVTSTVSTTGRTAPRFTIPITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W9</accession>
    <name>A0A7W7T8W9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30703" checksum="124692CF85E68D4A" modified="2021-06-02" version="1">MPGPGSDATAPVYIDTTKASIARVYDAFLNGKDNYEIDREVLRRVQQVAPEAATLAIDNRGFLIRATRFVAGQTGITQFLDCGSGLPTAENTHQVAQRIQPDARVVYVDNDPVVLAHGRALLEENDRTHFSAADIFEPRRILEDEVVRRHLDFSEPIALFQIGTLHHYNGTSPTTREIMAEYIDALPSGSYVAISHFFDPETEEHSAIARRMEQTFLHSPMGSGRFATRSELEGLFEGLELVEPGLVILADWWPDGPRLKELDAVSYCIAGAVGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T907</accession>
    <name>A0A7W7T907_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CPA2 family monovalent cation:H+ antiporter-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="14"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="41965" checksum="0A446B4C04F3A0B8" modified="2021-06-02" version="1">MHSTAIALIQLGAVFFGLGLLGRIAWRIGISPIPLYLIGGLAFGHGGFVPLSGIEEFAHIASEIGVILLLLLLGLEYSAAELMTGLKRSWTAGVLDIVLNAAPGAIVGLLLGWGPVGALAMAGVTYISSSGIIAKVLGDLGRLGNRETPVVLSVLVFEDLAMAVYLPILTAVLAGVSFLGGLSAVGISLAAITIVLLIALKYGRFVSAIVDSPDAEVFLLKLLGSALLVAGIASQLQVSAAVGAFLLGIAISGSTAENATRMLEPLRDLFAAMFFVVFGLNTDPASIPPVLGLAVALAVVTTATKVATGWWAAKRQGIAKLGRARAGAALVARGEFSIVIASLTVASGAVDGRLAALATAYVLLMAILGPVAARIVEPLAKLGAVWGWDHVVGVRVFNHMMAPRRCSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T986</accession>
    <name>A0A7W7T986_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="48169" checksum="A7FB8A05CFC20014" modified="2021-06-02" version="1">MPDATIAPNDPRTVALRHEGGEHEMKVVQATEGAPGIDLGKLLATTGLVTLDSGFVNTASCSSEITYIDGDAGILRYRGYPIEQLAEKSNFNEVSYLLIYGELPTAAQLEEFSSKISRHTLLHEDLKRFFDGFPRDAHPMPVLSSAVSALSTFYQDSLSPFDANQVEISTIRLLAKVPTIAAYAYKKSVGQPFLYPDNSLGLVENFLRMTFGFPAEPYDVDPDLVRALDLLFVLHADHEQNCSTSTVRLVGSSEANLFASISAGINALFGPLHGGANSAVLEMLEKIRNDGGDVAAFVKKVKNKEDGVRLMGFGHRVYKNYDPRAAIIKKTADEILGKLGGDDQLLDIAKKLEETALADDYFVSRKLYPNVDFYTGLIYRAMGFPTKFFTVLFALGRLPGWIAHWREMINDPATKIGRPRQIYTGPASRDFVSIDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G4</accession>
    <name>A0A7W7T9G4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">F4559_006396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15916" checksum="B929AEF2D692B950" modified="2021-06-02" version="1">MKPEEMVEAALAIAERAGETGDVPIGAVVYDPDGVELARACNAREALGDPTAHAEVLALREAASRFGDGWRLEGCTLVVTVEPCTMCAGALVLARVARVVFGAWEPRTGAVGSLWDVVRDRRLNHRPEVLGGVLADRCAELMERFFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J6</accession>
    <name>A0A7W7T9J6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5086" checksum="4C02F71368311092" modified="2021-06-02" version="1">MDDRGMTTAEYAVGTLAAAALGGVLFALLGGDWIGGLLRALLQEAFSTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P3</accession>
    <name>A0A7W7T9P3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein YdbS with pleckstrin-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="7765" checksum="7834BBAAC719BB23" modified="2021-06-02" version="1">MSVITACPLPFLLIAIVAAVLCVLLWRLVLSTGTAGFGLWLLAAHGDHTAVASLAVLLLAAALTVFAKPTGRRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P5</accession>
    <name>A0A7W7T9P5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zn-dependent M28 family amino/carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029514">
        <property type="entry name" value="Ape3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="PTHR12147:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030948004" evidence="4">
        <location>
            <begin position="30"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="5">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="6">
        <location>
            <begin position="245"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="505" mass="52166" checksum="E616572BF9F8B578" modified="2021-06-02" version="1">MSARTGIRRAAILAASASLALATAPIADAAPALDGPALAKKLTKAVSAEGVNRHLIAFQRIADRNAGNRSAGTSGYDASVDYVAGKLRAAGFDVDTPTFTYPVQVTDAATAKVGAASYEAIALTLSPQTPVGGITGPLRAVPQDATPGCEADDFAGQDFKGAVAVIRRGACTFDIKHRNAAAAGAIGVIVANNIDGKLSGVTLGTPGVVPTGGVSKADGDKLFAAAGQSVTLDLRYHEEQKVSRNVIATTKTGRRDNLVFAGAHLDSVANGAGINDNGSGSAGLLETALQLGSSPKLNNAVRFGWWGAEELGLIGSTKYVQSLTFEQQLDIALYLNFDMIGSPNAAYFVYDGDNSDAVGEPAGPYGSAQIEKAFVDYLTVEKKVQVEGTDFSGRSDYGEFIKHGIPAGGLFTGAEGIKTPEQVAKWGGTAGVAYDPNYHGKGDNLGNIDRVALDRNADALAWVTASYAISTESVNGVPARAIRAKARAASKSFHVEEHHTHDATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q0</accession>
    <name>A0A7W7T9Q0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030708574" description="Fibronectin type-III domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="413" mass="43525" checksum="DBF0B627912F8B83" modified="2021-06-02" version="1">MRRRALAIASVVAVLVGAVVVLREPAPAPPPEVEYLPDARSLSEPTLLSLTAHDATTARAAWTATGGVTDSGFEVRWGDRTVLVHGTEYDLTDLTPDRPVTVEVRALDAHGRRSAPATATTTPRYVPVTDSFSRESLGTPRWRVIDKGEGCLGVRDGLVEIACPAVDLVSTVPIGPGSRFSITTDGPTEGELVVALTPDDHQDLLPAERLPDSVYVRLTPTGAGVESDLPTGTGTMPAGGAFTPATRGVRHRWDLDVRAGSVIVSRDGVEVAGGAFALPWRSGRMRIAARGAAGTTLFTADIPGTPVAADSRPVWVELPPITALLPVPKVNAVPAGDRVRVVVEVGGRGRVEAVRGVELDLDGTKIADLYAERAAGGRYEWTFAVAPGEHRLTARVLPADGGQPTTTDFTFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9X5</accession>
    <name>A0A7W7T9X5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030836946" evidence="1">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="7764" checksum="38EFD8985EFF8FC1" modified="2021-06-02" version="1">MNLRKTLTVATAALGGALAGLTLTGGTASADAPTDDLEAVVHTPPNADAKLGRVLRVADIADLSGGRAVADGDVTIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA82</accession>
    <name>A0A7W7TA82_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SSS family solute:Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006758</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="546" mass="58551" checksum="0D1A478629580B71" modified="2021-06-02" version="1">MHWTELVVFSSLFLLVTVLGFVAARWQRGSTLDHLDEWGLGGRKFGSWITWFLVGGDIYTAYTFVAVPALVFGAGALGFYALPYTIVLYPIVFLPLVRMWSVSRVHGYVTPADFVRGRYGSHWLALIVALTGIVATMPYIALQLVGLEAVLRTMGLNGSGILGHAPLFIAFVILALYTYQSGLRAPALIAFVKDILIYVVILVAVIYLPAKFGGWGSVVDSAQEKFAATPNPNDGVLLSANNQLQYATLALGSALALFLYPHSLTGILASRGRGVIKRNMVALPAYSLLLGLLALIGFVAIPAGVKAITNQATGQPDTNTIVPVLFAQEFPSWFAGIAFAAIGIGALVPAAIMSIAAANLWTRNIYKEYVNRKATPAQEAKQAKIASLVVKFGAVAFIVLIDPAFSIDLQLMGGVMILQTLPAVAIALYTRWFHVWGLITGWLVGMTWGISLLYSIPGADKVKKPHFGGSALALDKVSLLGWHPFAGSTVQIYVGAVALIANLLVAAAVTVVAKRLRANNGTDRTNPEDYHADEDAKHLKPVAAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAE0</accession>
    <name>A0A7W7TAE0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF427 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10546" checksum="F43CA8C1B3D0C452" modified="2021-06-02" version="1">MVIATWNGQVVARSDDTEIVEGNHYFPADAVDREFLRPSDTTTVCPWKGTASYHSLEVDGAVNPDAAWYYPAPKEAAANIKDRIAFWRGVEVTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WSX7</accession>
    <name>A0A7W7WSX7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="154"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="281" mass="31129" checksum="138016A0D890F909" modified="2021-06-02" version="1">MSREDVLVSAAWSEENLTTPGVVFVEVDEDTTAYEGGHIPGAVRVDWKTELQDQVRRDFVDRAGFEKLLSEKGISNDDLVVLYGGNNNWFAAYAYWYFKLYGHTTVKLLDGGRKKWELDGRPLDKEVPSRAATNYTAQEQDLSIRAFRDEVVAAIGNKNLVDVRSPDEFSGKLLAPAHLPQEQAQRGGHIPSAINVPWSKAANEDGTFKSDEELAAIYGEAGFDGSRKTIAYCRIGERSSHTWFALHELLGHEDVKNYDGSWTEYGSLVGVPVELGDGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WSZ8</accession>
    <name>A0A7W7WSZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase (Regulator of RNase III)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="15892" checksum="2E9226EFCA067DD0" modified="2021-06-02" version="1">MIAEVRGNLLEAEADAIVNAVNTVGVMGKGIALAFKRAYPKNHAEYHAACARGELEVGRLLIHETGLEVPRYVINLPTKRHWRSRSRLADVVAGIAALREALVSLDVRSVAVPALGCGNGGLSWSEVGPAPHAGLADLPDVDIRLYLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT06</accession>
    <name>A0A7W7WT06_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline iminopeptidase</fullName>
            <ecNumber evidence="2">3.4.11.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="23212" checksum="F97AC0EFAEE34E95" modified="2021-06-02" version="1">MIADLDAVRRRYGLARVSLLGHSWGATLALRYAVAHPDRVEKLVYVSGTGLDEGWEEEFRANFTARLGDEWERWRELRSRRRTEDEERELAVLQWSADFADRSKARGYAERMANPWFEINYECNAVLGKETWPSAFTECRQLEVPTLIIDGAQDLRPRWSVDSLFETLPSAKRVVLEDAGHIPWLEVPDEFEAAVGAFLDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT2</accession>
    <name>A0A7W7WTT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="18372" checksum="A1E49DA738BFB336" modified="2021-06-02" version="1">MKLLGVIATAAVVGAVAVGTGNSQPGSVDDAWQGLGLKIVRKASHHDPACPPHTFGEVNQLMATMPCVSLSRTLMTLADDKGTTIVVHIAWVEYGTRAGAREFKRIEDIHGTGDVSPLPGATIGIADVRFTAHHYDSTINGTTTVTAEAEPLTGQPDDRLLEDVTRIAVLEPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT4</accession>
    <name>A0A7W7WTT4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="9948" checksum="5C38D9640E47E1DC" modified="2021-06-02" version="1">MTMWVSQPGPLEPIDITEGRNAPGLAAFESMVNSIAMYVLIGGLAAVVIGVGIAVVGPRLGFQHARGVGIGGVVGGVFLGAVVGLASVMINFAYSMFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU90</accession>
    <name>A0A7W7WU90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13576">
        <property type="entry name" value="Pentapeptide_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33927" checksum="3F368C3C393C8BB0" modified="2021-06-02" version="1">MDHPVLSARTIVVWGVGLAVVAVGSVVVLLVLLGRGEPRDAVRLDVVRTAASVVIGTGGAAALLLTARRQRYVELDLRQKDHDATERRVTELYGRAADQLGNDKAPVRLAGLYALERLGQGNAAHRQTIVNLVCAYLRMPFTPPPAARARVGVRDADRAQELEVRQTAVGVLTAHSRPDDVDAFWPDLDLDLSNATLVKFTFTHASVRSASFVGATFVDAATFRGTTFHRNADFRDARFAGLADFRRVTSGESAFRGAVFAGEVDFGVRTTVRLSGARVRPSSGRRRWPDGWTERQDESDLRFLVYDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ9</accession>
    <name>A0A7W7WUJ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29789" checksum="9253ACEB8A442DB9" modified="2021-06-02" version="1">MCPQRRRHHRVLVTEVRPWLEGSYTETVGRDLFAATAELAHLVGWMSGDAGHQGPAQRYYLHSHRLAAEAGAAETAATALRGLADQALDLGHVATAVRLAEAADRTGGTVPEPKARAYYATTHARAAAADHDPATARARLTAAHTAIGHADPTPGTSWAAHYSPSRWAHETARVHHRLGDLDAAEEHLHHALHLGIDRRRTQAQVTADLGHVLLHRGDLDAALDTWTRFADLATGIRSRRVTDSAADIAARLATLPEPRAHHLLDQLTTTFDHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK7</accession>
    <name>A0A7W7WUK7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23461" checksum="3F359DE210BC2FF2" modified="2021-06-02" version="1">MIRVLLADDDALVRGGLKALLDAEADIVVVGEAADGAEAVHRAAVVRPDVVVMDIRMPVRDGVSATRELMRTDPRPRVLVLTTFDLDEVVDDAIAAGADGFLLKRATPEELIAGIRTVAAGDAVVSPSVTRRLFEGYAARFEPDRDRATRLTEREADVLRALADGCSNAEIARELHLAVETVKTHISSVLMKLDVRDRTQAVVWAYRTGFVHRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUQ5</accession>
    <name>A0A7W7WUQ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21140" checksum="856CD25C9618D94F" modified="2021-06-02" version="1">MTTVVPRADLHPKLDLPLLRDIIHPERDLWTPRELRDLTSTVASELTTPLLDVLRFDSDHRWWLRLGLTEGVELWLLSWLPGQGTEPHDHGGAAGSFTVLTGELTEDYRYPGGPIRTAGRPVGAALGFGSGRAHVVTNKGTIGASSVHAYSPPLVPTREYESLWDIPGDIPPLPAQRLPLDVLRERADQEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX2</accession>
    <name>A0A7W7WUX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="2">2.1.1.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="413" mass="46665" checksum="09ED271637EB609A" modified="2021-06-02" version="1">MSTIDLPRPDRGIWPGLATPPRSPLRARIAESLFRNAVRTLPVRVVLPGGLRWGAGGPDAPEMRVHRPEAFFHRLGVDAKIGFGEAYMVGDWTTDRLADLLTAFAARLTTLIPPRLQALRRWVERRHPASDSNDVTNSRSNIHRHYDLSNDLFSVFLDETMTYSSALFDGPDDPLDVAQLRKIDGVLDYAHVRAGSRVLEIGTGWGALAIRAARRGASVTSLTLSAEQKALAESRVREAGVEDRVEIHLRDYREETGRYDAVVSVEMIEAVGGEYWPAYFAMVDRSLVPGGRFGLQAITMPHDRMLAAASSYTWIHKYIFPGGLIPSVRAIEETVRDHTGMRVVEQREFGPDYAETLRRWRTTFLARWDEVRALGFDETFRRMWEFYLAYSEAGFRVGYLGVRQFAAVKQREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY9</accession>
    <name>A0A7W7WUY9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="10">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alaS</name>
        <name evidence="12" type="ORF">F4559_001935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="1"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="891" mass="96499" checksum="1FF6CAE1CFEB5C63" modified="2021-06-02" version="1">MQTHEIVKRFREHFEKAGHKFVPSASLLLDDPNLLFVNAGMVPFKPYFLGEAPPPAPRMTSVQKCVRTPDIDEVGKTTRHLTFFQMAGNFSIGDYFKEDAIRLAWELVTNPQDQGGYGFDPERIWVTVYLDDDEAIELWQKVAGLPLERIQRRDVEDNFWSMGVPGPCGPCSEIYYDRGPEYGREGGPVVDEDRYLEIWNLVFMQNVRGEGGAKKDYPILGELPAKNIDTGMGVERVAYLLQGVDNVYETDLVRAVITKAEELSGRKYGDNETDDVRFRVIADHARSGVLLVGDGVTPGNEARGYVLRRLLRRIIRSSRLLGVTQPVLPLFAEVVRDSMGPAYPELVGGYARIEQVLKAEEDTFLRTLDSGSRIFETAAGQVKAEGLATLPGDKAFQLHDTYGFPIDLTLEMASEAGLTVDEDGFRKLMAEQRARAKADAAGKKTGHGDQTVYRELLELGATEFTGYTELASEATLRGIVHEGRRVRSAKEGDIVEVVLDRTPLYAESGGQESDAGTIVTANAELEVVDVQKVARKLWVHQVRVLSGEVAEGEHVEARVDPEWRIGARQGHSGTHVVHAALRQVLGPSALQSGSYNKPGYLRLDFAWTGGLSDAARSEIEEVSNLAVRKDLPVGVVYTDMKGAQDLGAVALFGETYDETVRVVEIGGPWSRELCGGTHVEHSSQIGPITLIGESSVGSGVRRIEAYVGIEAFQYLARERALVQNVAALLKVPDAEVPARVEALVERLRVAEKELDKVKSAQLLSGAGALADQALDVRGVAVVALALPGGTAAGDLRTIATEVRNRLGNRPGVVGLFAPDGDKVSFVVGTTAAARDLGLAAGKLVPAFAPAVGGRGGGKPDLAQGGGTNPAGVTEALAALRAEVDRVLEQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV21</accession>
    <name>A0A7W7WV21_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RND superfamily putative drug exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="98"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="441"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="669" mass="69459" checksum="A582F5B6C6DB1314" modified="2021-06-02" version="1">MHASPPSRSRWLLPALIAVAWLALGGLAGPFAGKLSQVAVNDNTAFLPSSAEATEVAEQLRAIDSTRSLPAIVVAERENGLDAADRGYLTGLKLPGKASPLVPSADAKAAQIVVALDAADPAEGVEKIRAAVANPPDGLTVLVAGPAAQVADLKEAFGGIDGLLLVVAGAVVAVILVLVYRSPLLPFVVLLSGVFALALASLVVYLLADNDVLDLNGQSQGILFILVFGAATDYALLLVSRFREELRDTEDRYTAMRTAWRATIEPIGASAGTVVLGVLCLLFSDLNSNKGLGPVAAIGIGAAFVASVTFLPAVLVLLGRSAFWPLRPKLGSPHPEAGGVWAKVAGLVSRRPRLVWVVTTLVLLVGVAFVPQLKASGTAQSDVFLTDVDSVAGQELLSRHFPAGSGAPSVVLVRADRAAAVVEAAKGVPGVSSVVPPRTFGDVARVDVVLADPVDSDAALATVERLRPAVRAVSEDAKVGGPTATQLDTRNTSEHDRLVIIPIVLVVIFLVLASLLRSILAPLLLIATVVLSFGATMGVSALVFNGVFDFPGADPVVPLFGFVFLVALGIDYNIFLMTRVREEAAVRGTREGMLHGLTITGGVITSAGVVLAATFSALAVLPILFLAQIAFIVAFGVLLDTLVVRSLLVPALGVDLGRRIWWPGRVDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA6</accession>
    <name>A0A7W7WVA6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="32100" checksum="7A799665B5616F33" modified="2021-06-02" version="1">MSARLIRVDGRPALRFERDFAASPVRVWRAVSEPDRLDHWFPAAVEIDGDVLRFTFPDSAPEVVTSGAVLEFTPPEVFAFRWNTDVLRFEVAAHGSGTRLVFTNTFEHERTAARTAAGWDSCLRALTARLDGSTVPPVTGWREPVERYVREFGLDRGHATGNEVRFVRDLMWQPVDAAWRVFHDEVGVATPQVPLGTVVARTAHVLVDEGPTGRVRREVRHDPDHGTWVALTHTVAEPGFVPTALASWHVQLDRLFAAAAGGPVPPWPADRFAALLADYTRRESSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW56</accession>
    <name>A0A7W7WW56_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="18155" checksum="A053BDA3DFD47098" modified="2021-06-02" version="1">MSPHELEVWFDAAQDETVPVLVRTDAELDALLDRLVDRDLPHPPNMTLTTRPLVGPHATPDHLVKIDTDRSAGLGAILLLGPLDIVPTTALDHDRIDPEGGIWVTRTDPPAPDTAPPLYIDKATRTRYPHDAALPLATWRIALHELLHTGLRPTTVDWQPSDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW93</accession>
    <name>A0A7W7WW93_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17144" checksum="1CE79977C9EF2025" modified="2021-06-02" version="1">MSQFVTKLAVGDDVRTVAELLNEIDAFYGDEVIESFEERLARVDSTLFGAHPMVYAILARADNGDVVGLATISYLWPAAGSTSSLYLKELFVRPGHRGKGAGKALMQAVFDQADKSGCSRVEWTTDRSNEEAQRFYESLSVAPHDGKIFYRRTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF9</accession>
    <name>A0A7W7WWF9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_003693</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="171"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="300"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4966334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="44508" checksum="FC8488ADBE158EBC" modified="2021-06-02" version="1">MPARYRYRIEPDAARQAMPARTFGCARVVFNDAIRCRTDAHQAGESISPAEVQGRVITAAKATEARAWLGEVASVAPVQSVRDAHRAYRNFFDSIAKRRKGRKVGHPEFKSRKDTRQSFRLTRNGFSLRPNGRLYVAKVGDVKVRWSRDLPSEPGSVTIILEPDGHHYASFVVEVAPTPLPPVEREAGLDLGITRLATVATSDGRRQDVANPKHLAGKLRKLARLEREKARRAKGGKNRARTGRKVAVQHGKVTRARRDYQHKQALNLIRDNQAVHVEDLNTAGMVRNRRLARAIHDAGWARFVRLLEEKAERHGRTVAKVSRWLPSSKTCSACGHLMAEMPLKVRTWTCPSCGTAHDRDHNAALNILAAGRAERLNACGAHVSPSVRVAMGDEAGTTPDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWI4</accession>
    <name>A0A7W7WWI4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-aminopeptidase/D-esterase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="37134" checksum="19D039E58D43A5D9" modified="2021-06-02" version="1">MRARELGLRLPGETGPLNAITDVPGVEVGYTTLIEGDSVRTGVTAILPRGKADVHVPCAAGRYSLNGNGEMTGSALLDEIGALRLPVLITNTHAIGPCHRGVIDWVAREHPAVADQWLLPVVAETWDGYLNDINGPHIRPEHAVAAIDAASSGPVEEGSVGGGTGMNCYAYKGGSGTSSRVVEYGSDTYTVGVFLQANFGSREELTVCGVPLGEALADDNPMADGDWSVPPGAGSVIVVVATDAPLLPGQCSALARRVPLGLARTGTAGSHFSGDIFLAFSTGNALSPSDFPRGEPGYDTLRHIPWNRIDDFFTAVVQAVEEAVLNALVAAGPMTGRNGRRSPGLPVDRVLELVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR3</accession>
    <name>A0A7W7WWR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="39130" checksum="85B7F6E236507952" modified="2021-06-02" version="1">MTGSTTRRDLLRLRAVLLVVTGLVVAASWFVVRDVHDRIGQVLARGAPAVLEATAAHAALAEADAFAIDAFDSGEAKLAGPGDRYQNRIAVASQSLTRVAEHNVAAAEGSRQIQLVEGLLVAYTGWIAQADAHYRQRSTLADVDLWYASRLVHAPGIGVLAELDQLARVQREALDRQLGESLAAPVWIGLLAVAALVLGVRLVLAQRYLRRRFRRRWNVPLLLGCGALLGLCAVVVFGVLAQYRAEVAAGELRGVTDAWAQRAAVAGDRGQRELRGLVTRTCERVCGETVDRFVAGLPAVPRVEAVAEHELTTRVKAVNERIAAADRMAGVEPLVPVAGVLVLVAVWSGFRPRLAEYRYEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR6</accession>
    <name>A0A7W7WWR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="408" mass="45379" checksum="6B8344C3B37A663F" modified="2021-06-02" version="1">MNDSATTSTALKSYDLFAPDVLGDPLPLLHRIRAESPVSWIPELESFLVTRHADVVAALKDKRLVPGNLGQAFDRLSPAELAELEPVRQSIALWMGHTDEKDHVRFQQLLKRYFTPATVEGLRPRIREIAIELIEARREGGFMEVVTELAYPLPANVIAEMLGMPTADREKLQEWSRDLLALFQLADFETLRQSQRSILEMQDYVRALVAQRREEARDDLLSMFVAAEREGLVSEDEIVANCVLLLFAGHETTANLIAMGLGLLLEDQGQFDRLKADHGLIPTAVEEMLRVRGPASTLVRIATEPVEVAGTTYPAGSHFLLAMVSGNHDPEVFENPDTFDIGRKPNRHTAFGMGAFYCLGAALARAETAECLDVVLERMPDIRPAYDEISVVSSPPLSRHLASLPVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU7</accession>
    <name>A0A7W7WWU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Rossmann-fold nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9041" checksum="A7E26AA3B4B67EB4" modified="2021-06-02" version="1">MGAVADAALAAGGEVVGVIPGFLVDLEIAHTGLTELRVVGTLHERKALMLELSDAVVALPGGTGTLFACDRRHDQPNARRPAGTVANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY4</accession>
    <name>A0A7W7WWY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="81" mass="9157" checksum="2A57167846C4B57E" modified="2021-06-02" version="1">MMRAPSWDSASADLVAPGEFGWVRQDGEWLHVRVQPYDEALVRALGGVISVCNRRGIYRNYFPWEIHRNRGASGLGDGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH3</accession>
    <name>A0A7W7WXH3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030774382" evidence="1">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38224" checksum="2089E64286EBAC70" modified="2021-06-02" version="1">MQLALVLAATAALTTSPAAPATVTEILPPAGYRSVSAYALNDAGQIAGTAYPESGPGRAHLWHGGAVTALGVGAAVAIGRNGHVIISEFTGTNGRVTQKVFLYHDGVRRDISPPGEGYAGAGTVSGNGTVPMSYSDSAYSGNVNRVGVRRGGRFAEVTIPDFGPQVGVRAVNDGGEFVGSTYRTSAFRCDAEDVCTRLPVPPGVTDPTPNALNESGVVVGYGFTAAGQVPLRWDHAGVTVLHDGPGAPAGREQAVNERGDVVGWRQVDGVRRATLWRDGAAVDLGRPGEEYSETIAVNDLGQVVGRSRVDGREVAWVWHRGRYTVLPSLGGAWTSPMVINNTGTVVGTAVDAEGRNRAVRWTIRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK6</accession>
    <name>A0A7W7WXK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="327"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="512" mass="54822" checksum="BEC0CF84409EE109" modified="2021-06-02" version="1">MVVLSAIVLVGVVYVVAGAYAYRVQPHNRIGPLMVLIGIGWFLDFTVDQTVSYPLRLSAATWPALLGHVLVAFPSGRLRTTPRRLAVGAGYLEAVLLTGIKSFAPADSPWAHAADVTETPMTLTVGGVMLALLIAQWRVASPAQRRTLTSMLGASAVAITFFGAWEPVGFADDMSSVLIMTVSMIGMPAAYLAGLLRRRMDRGKVADLVVRLSDDRHPATVREALADALHDPGLRIGYWVAEQDRYVDESGADLEPAAPHVRTRVDRAGRPVAVLLHDPVLDPDLVRAACAAVALALENERLTAELRARLRQLADSRHRVLLAAETERRRLERDLHDGVQQRLLSVAMTLGLAESLPPERGPALAAEAKTSVLATIDDLRALCTGLHPPVLTERGLRGAVRELAALARQVEVDFDVDTPLPPQVETTAYYVVAEALANVTKHAEATRTRIGITGRDGVLLVRVDDDGRGGADPTAGSGLRGLGDRVESVGGTMRVVSEPTGTSVRVELPCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL9</accession>
    <name>A0A7W7WXL9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-associated heat shock protein Hsp15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="13189" checksum="947E6AA8DF28F288" modified="2021-06-02" version="1">MESTRVDRWLWAVRLTKTRPDAAAACRAGHVRINDRPAKPASTVVPGDQVRARVGDTTRIVEVVRVIQKRVGAADAVTCFLDRTPKPPPEVPVAKRDRGAGRPTKRERRELDRFRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN1</accession>
    <name>A0A7W7WXN1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(d)CMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="4">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21059" checksum="1E40B5CFDC675900" modified="2021-06-02" version="1">MGTVEWLAAWAAQAGGRVVVGIDGPGAAGKSTLAAALAAELGAVVVHTDDFHLPSAERVGNGYDLARLRVEVFEPAAVGKTTRYRRYDWPDDRLADWVQLPGDVPLVVEGVYSTSSAVRGFCTTTVFCRASPEVRLSRGLARDGEAARSRWVDEWMPAEDRYFAAERVEEAADVVVLGEHGEFRVIQSRRPGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN8</accession>
    <name>A0A7W7WXN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="331"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="44659" checksum="CC3CAC9764B4DCDC" modified="2021-06-02" version="1">MTAGDVRMPRSGVLSTVVREPLSRRAWLATMHLAVGAPLASITALALVVLGVVSAMLALTVVGSLACLAGLVATVDAATTVQRTRFAAFLEIGIQVARRDPPDGSSTRRLIARLREQLTWRRVGYHLLAGLLAPLSAAVVLGSWVAGVVLPLFAVVRLVDGDYERSTGPVGLGLLGLSLLFAAPWAALGLSALDVLLARTLLERSARDVLAEKVESLVESRAGLMEAADAERRRIERDLHDGAQQQLTSLAMNLGIARQTLPDLEEPVRSVIVSAHEDAKSALADLRNLVRGLHPAVLDERGLDAALAGVCARSPVPVRLRVDVDVRPSAGIEAIAYFVVSESLTNIAKHAQAKSVEVSVRTVGGRAVGGRLSVEVVDDGVGGAVERDGSGLRGLRQRVAAVDGALVVDSRPGRGTTIRAELPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXV2</accession>
    <name>A0A7W7WXV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030517868" evidence="3">
        <location>
            <begin position="29"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="4">
        <location>
            <begin position="410"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="510" mass="52652" checksum="20AB32C39B00C39B" modified="2021-06-02" version="1">MRHAALVMAALSALAACSAGPSNRPVIAVQGDGETTGAAVPAGPRETPPLDDMDPTGITWSGCVEATKDRMGGTAPAGDWAYRCARLTVRLDMPSRPGRGSLGMALLGIGTGKSPLVVIGDPDGEPGTLKAARLAATLPPSLLSTFTLIGVDRRGTGNSDGVQCVPEIARLGIVEADPAEQSQEDLLEDIGRASQDCVLDLENRLPAVDSWRAAADLEQLREAMGVDHLNAIGIGDGSKVLTLYASRYPERVGRLVFDGAPDPALDVAGVTEAKAVSAESTFAAFEKDCVVRSCALGADATKRFTALLSTLRTRPIRGYDFDLTPGTATVAVLAGLADRGAWPALADAIVAAEGGNAEPFAAFLRPIVTGDSENPPRLDAGLVTECNDTATRLPPERVAAMATDWQGKHPLFGAYFARQLLRCGPFPVPQNPKPAKIASAPPVLVVTTADDPVTPKSGSERAAQALPAGVRVDWSGGGHGAVGRSSCATSAVEQFLVSAKVPTSGMSCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY47</accession>
    <name>A0A7W7WY47_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12235" checksum="19DF0E9FF67583BB" modified="2021-06-02" version="1">MTGTTTTVGTEHDYREAARDVMRHDGPCHLDLRSAIARTYLDLADVVAYAEKVECGERERFTADVSAACGHLSAALSAENGEGWREREAATVFVRLAVTAPRLRRRAVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYH5</accession>
    <name>A0A7W7WYH5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp</name>
        <name evidence="12" type="ORF">F4559_005072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36264" checksum="95DAB6A24B6EAC92" modified="2021-06-02" version="1">MRIGVLTGGGDCPGLNAVIRGVVRKGIEVHGWEVVGFRNGWQGPLENLTRPLGLPDVEDILTRGGTILGSSRTNPYKVEGGVDKIREVLAANGVDALVAIGGEDTLGVAKRLTDDGIGVVGVPKTIDNDLGSTDYTFGFDTAVHIATEAIDRLRTTAESHHRALVVEVMGRHAGWIALHSGLAGGANGILVPERQFSVEKVVEWVERRFEREYAPIIVVAEGAIPEGGAEVLHSGEKDAFGHVRLGGVGQWLAEEIAERTGKESRAVVLGHVQRGGTPTAYDRVLATRFGLHAVDAVAEGDFGVMVALKGTDIVRVKLSEATAELKTVPTERYSEAEVFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYI7</accession>
    <name>A0A7W7WYI7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045635">
        <property type="entry name" value="DUF6412"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19950">
        <property type="entry name" value="DUF6412"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9702" checksum="659CAC81646D0A5F" modified="2021-06-02" version="1">MARLQLFLALYLPVLFTLTLVDQPAGLIVAATAVLLLLVVAAPVVRSAPAWVRSLSLRGKSLRTAFLRLRDPDAAGRPRPRAPGQRFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ52</accession>
    <name>A0A7W7WZ52_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial proteasome activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bpa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019695">
        <property type="entry name" value="Proteasome_act"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10759">
        <property type="entry name" value="DUF2587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19273" checksum="92029FA777F797E7" modified="2021-06-02" version="1">MSEGREKERHVVVVGPDGTPVTTARVPAGEEDAPGITDLVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRNRLKEIHKRSVLELEDGLAPELREELERLSLPFTEEGTPSDAELRIAQAQLVGWLEGVFHGIQTALFAQQMSARAQLEQMRGRALPAGSSGEHEHGPNPRGTGQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA1</accession>
    <name>A0A7W7WZA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Streptogrisin C</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004236">
        <property type="entry name" value="Pept_S1_alpha_lytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035070">
        <property type="entry name" value="Streptogrisin_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02983">
        <property type="entry name" value="Pro_Al_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001134">
        <property type="entry name" value="Streptogrisin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="8">
        <location>
            <begin position="378"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="43459" checksum="20932A9B4B726E34" modified="2021-06-02" version="1">MAVALTSSATAGPPTQPADSAMIAAMARDFGITTDQARDRLVREDAASRTEGDLKAKLGPAYAGAWLNGDASQLTVAATSDSQIQTIRNAGATPKLVKNNLGTLDALKTKLDNNARKVTKAVPGWYVDVQNNTVVVLTRDTAGAKQFVKSAGVNEADVRFEQSVEDPKPYIDVVGGNAYYIGSGSRCSVGFSVTNGGFVTAGHCGTQGASTTQPSGSFAGSSFPGNDYAWVRVSAGNTMKPEVNRYPGTVQVNGSTEAAVGASVCRSGSTTGWHCGTIQQKNASVSYQEGTVTGLTRTNACAEPGDSGGSWLAGDQAQGVTSGGSGTCSGGTPVMYFQPVNEILQAYGLTLMTSGGGGTTTTNPTGPTGPTGPTNPGNTTWKQGTAYAAGATVTYNGANYRCLQGHTAQPGWEPPSVPALWQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZH1</accession>
    <name>A0A7W7WZH1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025591">
        <property type="entry name" value="RloB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13707">
        <property type="entry name" value="RloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="23595" checksum="4346847E5B127299" modified="2021-06-02" version="1">MARRTTIDRNLRRKTATRPERRTIVVFCEGVASEPDYINGLKRLPEVRSNTAISIEIDPESGVPDPLKLVRLAIARAEDDEVDECWCVFDVEWPQHHANLASAVDLAERNNIRLAISNPCFELWLALHFKDWAAHLNTADAERLSRKLDGRQGKHIDAAKYLPLRQEASRRATTLAARHRRDGTTSPHDNPSSSMVDFLATVESPPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZM4</accession>
    <name>A0A7W7WZM4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prim-Pol domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prim-Pol" evidence="2">
        <location>
            <begin position="12"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35497" checksum="D5B63271D25E3CEE" modified="2021-06-02" version="1">MDRATTTLMRHALDAAAQGFHLFPLRPGEKTTALHGERRCPRTGPCRSGHLKPEQRATTDPAVIERCWSAGPFNIGIATGPSGLVVVDLDTRKSPDDLPPDGWNRRGIVDGHDVFTAVCEDAGHPVPWETRTVRTARGGTHLYFRAPAGVALRNTEGNTGAGLGWKVDTRAWGGHVVGPGSTTPHGDYRVIEDAPVVDLPDWLVGRLTPKLPPVRTSPIVSRSERLPAYVTAAVEGERNRVAAAQPGVHTRTLFVASVALGQLVGAGLLPPATAEAELFNAAMSVIGTPGCRCTDREVLRTIGNGLRAGASRPRQTPQDRPTTTAMFDHRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXG7</accession>
    <name>A0A7W7SXG7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17108" checksum="E1B1E9FB25BC0031" modified="2021-06-02" version="1">MTPPRVLEISRLLWVASALVGMLRFVVQLADRDMLIDELLRQNPGLGQDEIDLTVNGSIVVGLLFGGLLVLVYALLSRRMLSGRNWARVVLTVFGAIGVFVGLGRSLLVVSGAAAAAGVAVTAVDVVAGLVTAALDGTAAVLMYRSASSAYFAAVTRARAVGGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXG9</accession>
    <name>A0A7W7SXG9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein-anchoring transpeptidase ErfK/SrfK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030729354" evidence="4">
        <location>
            <begin position="26"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="48"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="40742" checksum="D258A50E19A2E202" modified="2021-06-02" version="1">MLRKLTALLLGGALLVGCSSGTEQGTPKSEGKDAAPVAKFVAEPASGAADVPVTTPVKVTVSDGTIDQVTLTNPEGAAVAGKLADDKKSWQTTEPLGFGKAYTYAGKATGTDGKSVELTGSFTTSTPTSQVRATLFPGDDQQVGVAVPIMVKLDQEPADRATVEKALIVTNSAGIKGSWAWLSGTEVHYRPEKYWPADTKIHVEAKLYGVDYGNGAVGRADVTSDFTIGRNQVVKIDTPTHQLVVQRDGQTVATYPASFGKDDDAELTTPNGTFVVMQKDPQFSFDNPRYGYTNVLKKWAVRFSNHGEFIHENNDNAANIGKVNSSHGCANLLEADAKAYYDSALVGDPVEVTGSITTLPAQFDWYDWQIPWSQWVTMSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY79</accession>
    <name>A0A7W7SY79_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="9" type="ORF">F4559_000220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15361" checksum="A543E71B33578A73" modified="2021-06-02" version="1">MSEGREQDQPDERESVNRPSTAAARRERRGTARPAGRKDSAARPSEAGEVAKADSVTEDKKGRPTRNRDGQEKRPGLFKRFGRFVREVVSELRKVIWPTRKQMVTYTSVVLVFVAFMVALVYGLDAGFTAVVFQVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYD4</accession>
    <name>A0A7W7SYD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphoglycerate mutase</fullName>
            <ecNumber evidence="1">5.4.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21641" checksum="943E3B60F5011EDF" modified="2021-06-02" version="1">MSAHVYLLRHGQTTWSESGRHTGRTDVPLTDTGVQQARRAGAVLARLRGTDLPPALVLSSPRERARRTAELAGLAADHTEDLAEWDYGAYEGLTTPQIRESTKDWTVWDHPVPEGETHERIHERAQRVLAAVRTALPAGDVVLVGHGHFSRVLIAAWLGLPPRDGVHFGLDPAGITVLGDERGDPQVHRSNVPAWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYD6</accession>
    <name>A0A7W7SYD6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GT2 family glycosyltransferase/glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="829" mass="91889" checksum="1D1987E6A9AF30B5" modified="2021-06-02" version="1">MERAILPEVSVVVVNYRGAEDTITCLRALRDDLAYPADKLQVVVVDNASGDGGADRIRAAFPDVTVVDSPTNQGFAGGCNLGVEHATGAVLAFLNNDARPHRDWLTEAVRVLRREPGVGAVASKVLDWEGRTIDFVDGGLTWFGMGYKRHAGQPDDGSHDVPRDVLFGTGSALVVRTSVFKSLNGFDERFFMFYEDVDLGWRMNLRGWRVRYEPASLTYHRHHASMSTVDISRELYLLERNALAALYKNLSDETLAKVLPAALALVVRRATARGDIDPRQLEITRRPADPADDAAPVPVPRQALAGFLAIDQFVELMPSLAESRKKEQAARRRTDADLVPLMRKAMEPAYPLPRYLAAHEILVDLFGLDEVFGRPRRVLVLTGDAISEKMAGPAIRAWNMADVLSGEHEVRLVTVNPLCTPPDAPFPVLRVRTGDVGEQVAWADVVVLQGHAMEYVPSLKDAANTKIVVCDMYDPMHLELLEQGKDDTDEQREKDLLGVTKVLNNQLRRGDFFLCASERQRHFWLGHLAALGRLTPSLYDNDPTVRSLLAIAPFGLSGKPPQRTGPGLRATLGLAESDKVVLWAGGVYSWFDPLTLVAAIDTLRARRPDVRLVFLGMKHPNPEVPDMDIAGRTRALAKRLELTGTHVFFNETWVPYQDRQNWLLDADCGVTTHYEHVETTFAFRTRVLDYLWSGLPIVTTDGDSFADLVRREGLGVVVGSEDPDALADALEKALYDKEFADACAERIAAVRERFTWEVALAPLVEFCRDPRPATDRLPGSATLVRNRPLALGEKLQRDVKLVKEYLDAGGAGEVARRATGRVLKKLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYY0</accession>
    <name>A0A7W7SYY0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6658" checksum="1FB890D0D174725B" modified="2021-06-02" version="1">MAQPHGWIDCHDPFGRDRSMTVLVADDRVLLVAPPGESAVMSVTQTRRLRALLGQAARRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG9</accession>
    <name>A0A7W7SZG9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="625" mass="59667" checksum="906809413B6A3F74" modified="2021-06-02" version="1">MAAPAYGSAGTYYNPGGTGTSAVVAVPSGVVSGDVVLVALYKENSATVTPPSGFTEVSSTPVTTTSSGVHTLHVFWKRATGADSGTYTFSWTGAVYREGSAQRYTGVVTSGNPFDVQNSAQRSSNGTATPAVTVTTTGADRLLVWAATSWAGGAWTPPTGYTERVDTSADLTVATVVQASSGSSGSVTGTCAGSSAQTAWLGALLPVSGASTVDATATLAASSTLAAAGTVTTPATAALVASSTLSAAATTTTSATATLAADSAFTAAAAIARPAAVTLAADSALTAVGTVDRPATATLPAESTLTAIVDRTAVTTTLLAGTATLTADAVATRTTGATLTASSSLSSGADRTATTTVGLSATSTVTADPTVVRPAAATLTATGTLTAGADRTAVTSAVLAGTSGLTADAAVTRPATAVLTGTSTLTADPGGALPATAGLTGSTTLAATAVRSTHPDAQLAATSTLTTTATRTTTGAAQAVADSQLAATAGLTTTASGTLTASSSLTAAAVVSAGGVGASLTGGSSLTATAVRDAPALAVLVGAATLTTSGAVHAPAVALLAGTSALAASTTSTHTATATLTATSALAATATGESGELDDVFALGRIGTGWTLGRFGSGWRAGRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU0</accession>
    <name>A0A7W7SZU0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-beta hydrolase superfamily lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="34"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="35031" checksum="7C119C18E5C4BE42" modified="2021-06-02" version="1">MTVDVLGDDYETRTLPLGGGDVTATLVRKRAEHPVRGAVLYVHGFADYFFQRHVAEHFTRRSFDFYAVDLRAYGRSLRPGQLANHVTDLTEHFEEIDASVRIVREEDGHRDVVLMGHSTGGLTASLWAHERRRDGLIDALVLNSPWLDLAEPWFLRTVGTAVIRGVGRFAPRLVVRSGLGSVYGQSIHRDHHGEWDFDLGWKPIEAFPVTAGWLRAVRRAHATLHRGLDVRVPVLLLRSAHSHLHARKWSVEAMTSDTVLDVEHMRRWGPKIGRDVTVVTVDNGMHDLFLSAEPVRRRALAEVDEFLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX8</accession>
    <name>A0A7W7SZX8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="19414" checksum="350ED7B3924F812C" modified="2021-06-02" version="1">MADADVRSARSGDVDELARIHRDTWRTAYTDLLPDDVLVALDATPTLSLAVESGQLLVATEGRWLVGYCLAGGATEADTADVSGTPHEDAATTAIVTVLVEPRWGRRGHGSRLLDTAARQLVEAGATRGIAWIPESDRATRNFFERHEWTPDGTVRTLDAGGRPVREIRVSRGLTPLSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T095</accession>
    <name>A0A7W7T095_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein DedA with SNARE-associated domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23021" checksum="B9F53D44D00A4345" modified="2021-06-02" version="1">MALLTDLLEGLADLPQPAVLAVTGGLTLAECTIGVGFIAPGESALLLAATTATTVPRFVVMWLVVSLCAIAGDSIGYFLGRRYGDRLRDSKVVRKLGQEHWDRAGALLRRRGAWAVFFARFMPVVRTLVPASAGASRLEYRRFLPASIAGAMGWSALHIGIGSAAGASAKMIESTFNGAMWVLMGVAAVVGLVVFLRRRNRRRAQVRPRELEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N0</accession>
    <name>A0A7W7T0N0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase (Regulator of RNase III)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="17391" checksum="7210292F5C6B2D09" modified="2021-06-02" version="1">MVDIEVVRGDITEENVDAVVTAANESLMGGGGVDGAIHRAAGARLAEAGARLAPCHAGDAKATPAFDLTPPVRHVIHTVGPVWEGGIADESRILASCYRRGLEVADELGARTVAFPAIATGVYGYPPAEAARIAVDTIRSAATSVRLVRLVAFDEDTYALLVSLVDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S1</accession>
    <name>A0A7W7T0S1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="30849" checksum="BF560C5DE5E92D8D" modified="2021-06-02" version="1">MSLALLVPGGRGQLGHDLVGAAPADGLVHAPSSAELDLTDAAAVVDAVASFAATARDGGLRPVVVNAAAYTAVDAAETDEERAFAVNAVGPGSLAAACAAHNVPLLHVSTDYVFPGDGTEPYAADAPTGPRSAYGRTKLAGERRVLEAWERSWVVRTAWVYGANGANFVKTIARLAGERETLSVVDDQRGSPTWSLDLARGLVELASLVVRTDVPGRVLHATGGGETTWCGFARAVFEELGLDPARVRPCGTEDFPRPAPRPAYSVLSGAEWAAAGLTPLRPWRDALHEAVTSGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V6</accession>
    <name>A0A7W7T0V6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
            <ecNumber evidence="6">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009470">
        <property type="entry name" value="Chi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06483">
        <property type="entry name" value="ChiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="21"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="740" mass="79233" checksum="DC4BB50B35739F1B" modified="2021-06-02" version="1">MPYCSVYDAEGREQLGEGKSRRVIGYFSSWRTGANGTPAYLASDIPWTKVTHLNYAFAHIDGNNKVSVGSDNANNPSTGLNLPGLDPALPYKGHFNLLTKYKKQYPNVKTLISVGGWAETGGYFDDAGKRVASGGFYKLGQQPQATIDAFADSAVDFIKKYGFNGVDIDYEYATSNKYAGNPDDFWISDANRGTLWAGYEKIMKALREKLDRAGAADGKHYMLTAAVPASGWLLRGQEAYQVTKYLDYLNMMTYDLHGAWNHFVGPNASLYDNGKDAELAAGGVYGAGQYEGIGYLNTDWAYHYFRGSMQAGRINAGVPFYTRGWQGVNGGTNGLWGTAPLPDQKKCPPGTGGTVGSTTPCGNGAVGIDNLWHDLDTAGAEVPAGANPMWHAKNLENGITPDYLSAYGLDPANDPADRISGTYTRNYDSSLVAPWLWNSQKKVFLSTEDEQSLATKAKYVADKGLGGIMIWELAGDYKYDSAKKQYVQGDTLITAINQGLNGATPYGAKKANGTQPTDVLDVSVSIGGFALGDSNYPINPKLKFTNNSTVTIPGGAKIEFDYATSAPGSMADQSGFGLKVTSKGHSGPNVGGIKGDFQHVELTLPSWQSLPAKASIDVALSYQLPISSPSNFKFTFGGKSYAITADYPRGTTGGGNPTTTNPTTTTSPTTVTTDPTTTVPTTTTTTPPACSLPPWDAGKVYTGGQQVSHKGKKWQANWWTQNNEPGTGGQWGPWKDLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X4</accession>
    <name>A0A7W7T0X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system LytT family sensor kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="284"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="42305" checksum="8E9C3B560416D6FA" modified="2021-06-02" version="1">MTGFLAAGAILLVGAAVVLTLWRTSRGRNDFLTEAQRITFETLHTAWSAAPPLRAGLVPDAAKKSARHLRTLLGTPALALTDETEVVAWEGGGEHHAADAMRLARDVFETGRTRAFDIACAEPDCPVHTAVFAPLTVEGRVVGVLAAYSREASAGLVRATNEVARWASGQLELAELDRSRTRLVEAEVRALRAQISPHFIYNSLSAIASYVRTNPERARTLLLDFADFTRYSFRRAGDFTTLSEELRSIDQYLALERARFGERLDVTLQIAPEVLPVTIPFLCLQPLVENAVRHGMEGKVGPGRITILAADAGEEAHITVEDDGIGMDPDTVRRTLAGQVDDTAGIGLGNIDERLRRCYGDDYGLVVETAPGLGTKISVRVPKYQAGVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X7</accession>
    <name>A0A7W7T0X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12209" checksum="BE8CC0A59B0ED3FE" modified="2021-06-02" version="1">MAQQTVVQLIDDLDGSEAAETLTFALDGVEYSIDLSKDNADKLRDSLADFVAKARRAGGRKQRKGSGKSTVKAGDKAQAQAIRDWARAQGHQISDRGRIPQGLVVQFQEAHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E9</accession>
    <name>A0A7W7T1E9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="20668" checksum="5195C9839B4A5C51" modified="2021-06-02" version="1">MNTALVLGGTGMLKGCVDDLVDQGWYVVLPCRRPQPGLGQAARTALRRRGHVPHRARSGGQRSVEADWGQPAELAERVADALGGHADLLVAWVHAAYRDEVLRAVGPLLAPRAPVVEVHDSPAISAVRGMPDPVLPDHPTQQVVLGHIRDGGRLRWLTHHETSVGVSEAVLRALAGRAPSVHHVGVVDRYDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X5</accession>
    <name>A0A7W7T1X5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="238"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="436" mass="46363" checksum="CB04B7ACCC668817" modified="2021-06-02" version="1">MDGLAHTLVPAAGDAPVVLLRTPYGRHHHLAEAHAWAERGFSCVIGDVRGRHGSTGEFRPYRHETDDGASVVDHLARLGFGRVLAAGASYAAHCAVTAAIARPDAVVGVLAAVPALGLGETAREPGGAARLACRVGWWGEHVSPPAREVDLGTVPVIDALTGWSDLWHAPERTALWRDLAGLTMPLLAVGGLRDPFAADTERLAAAWGGPTRLVLGPWGHALDVGGTLGGRRIGALYLAWARRLADQRGDRAFVHTAGWRRHVPATLRRELAVRSGEFVADPADPFRSVPPDAAVAPASRSAAELTTPALPAGELRGSARVTLDVVADAPDADWVVRLSLDGVHLVHGIRRVRHEPGVPATVAVDLPPLGRVLAEGARLRVEVAGHHWPRHARNPHTGEDPVTARRLLPGRRRVLAGRVDLPWHPVGADVPLLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y2</accession>
    <name>A0A7W7T1Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein/thioester reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="964"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1431" mass="151219" checksum="F779F94838A1CE10" modified="2021-06-02" version="1">MTDDQRERLLAKLMARQGLRSAGLPRRPGGADVPLSGNQRGLWLAGQLGDDSGAYVMYAAIRVTGTLDVERLRDAVAVVVDRHEALRTRVVEVDGVPAQEIVPATASVTCTDVESLDDAVRSEVDTPFDLGAAPLFRVRVFRSDDVTAVVLSAHHIVCDDVSLAVVAEEIGAAYQGGTSFAPVGQFPDFVHWQAGRLAEGDRARMLDHWASRLADAPPVLDLAGDRPRTPHRSIAGDSHRFTVPAALAARLTEVTREQGATTFAGLLAAFAVVLSRRSGTDDVVIGSPTTDRPFPALERAVGMFVTTTALRVDLSGDPTVAELLARTRTTAVEALDHAGVSFDEVTARVAPRRDPAHHPLFQVMLVLNRGSGGGTWAGLPATTLPVTRGTSRFDLTLHVRETDGDWPVDLDYRTDLFSPDTAARLADQVLVTLSALVRDPAARLSTLDTTPPADHAAAEALHGVPVAPVDDVLTRIAAAVANHPDTTAVLDLGSGAEITFAELDRRADHVANLLRSHGVGPSVPVGLAARAGVEGLSGLLGVLKAGGAYVPLDPAHPPARLAGLLESCGAPVVLAPAEVDLGPYGGVVLTSWSGEAEGFEVTRGDLAYVIHTSGSTGTPKGVEVGHASLAHLTDSFVAVHGFAAGHRILMIPPLSFDASVGDVFPAWSVGAAIVVHPEPAAIDGPGLLRLCADHGITAVDAPAALLKRWVADLDGVVDVSTGPLGLVMFGGEAVPVATVAAFARITGGRVRLVNHYGPTETTVCATTFTTVEASEVDSRSATLPIGRPLPGVRAYVLDARLRPVPLGVPGQLHVGGVAPAWGYRDDPARTAAAYLPDPVVPGGRVYRTGDLVRSLPDGNLEFLGRVDDQVKLRGHRIEPGEVRAALLAHPDVTEAAVTVRGDVLVGYVVGAVDPAGVRAFCADRLPAAMLPGAVVVLDGLPLTRHGKVDFAALPDPTPGVEYEAPRTDVERVLAEVWSEVLGVPVVGRRDTFFGLGGHSLVAAAVLGRVRSLLGVTVPLRALFATADLAELAEVVERAHDDTYTFRSGLPTAEQMHADAEPPADIVPAATTVDAVSRVFLTGSTGFLGAYLLSELLARSSYEVHCLVRAETPDLALDRIVANFRRAGVDVPAGHLARIVPVVGDLSRPLMGLTEDEFDLLARSMDAVYHNGAVMNFVLTYRWMMPSHVGSTIDILRLVTRHRTKPLHLTSTLGVFLGTAYDRRPVTEAVRCDDPTGLDTGYNTTKWVADRMAVLARDRGVPVSIHRIAAIGGDVRTGRAQTASYLSRQIAACAQLGAVPDSGDVLDMLPVDRVGAAVAALSLDSVATDYHYYRSDGFTYADLGGVLTERGYPTRVLPFEQWRTLMLDHPETAFGPLAYGLSGRRRAHPVFDCTRTFTAAAAHGVEFPPADAEMLGRHVDHLITAGAMPERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T299</accession>
    <name>A0A7W7T299_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="85"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="30174" checksum="BC3BB972D7B1C22C" modified="2021-06-02" version="1">MGITTALAALTRGDREEARTAATHADGLLARALARHLSGPAAGHVYDQPAAFGAFIAGGGNVGLYAAVVDVLAATYATRLPDSLLDVGCGDGRALVPALHRGHRPDHISLVEPSAALLAAAERALIGPVVSYNTTVQDFLTATRDRFDLVQSTFALHALPHDERDTVLAALRPRTDVLAVVEFDVPDLAHGTPGHLEFLADAYERGLAEYEHEHEGDLVAQGFLMPVLTGQLLPGAVRATWEQPADSWARQVAKAGFADVTTTRLHDYWWSPAFLLTARGGPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K2</accession>
    <name>A0A7W7T2K2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="SSF49695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28010" checksum="81EBD5C1966B5EE0" modified="2021-06-02" version="1">MKTTRGRETVDSKPGWRLPRSVVRWSAAALPAILGVFVGAGPVPAMAYAPETASAVRDAAAIHHVPTVPLSINGRPVPGETILAYNGYVLHMAYFPGSDGAPGRLHTFTTPDALEKFVHSRGGPEHALAKPSKHANPDTPGVGWRVVGPGARGGDGVSSYGWDTTGSIIFEHMEFSGCGLFLEKNYGYQRLTHVYGCMWPNDWNDETSSVKNSPYGSTATVLYEHTYYNGSTLYIPYSGFNHYLEGVGWNDRTSSFASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T0</accession>
    <name>A0A7W7T2T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FkbO/Hyg5 family chorismatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031038">
        <property type="entry name" value="Chori_FkbO_Hyg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04444">
        <property type="entry name" value="chori_FkbO_Hyg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR631038-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR631038-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="35390" checksum="31D40CBF8BEC16AB" modified="2021-06-02" version="1">MTVDSAVPVRGIGSAFEPVGTDVGDRNVLGRVVFSDLGVQPAIADGVPTVIVPMGGGFQEVFTSERPVRTGVDGRLVYAEDGERLFCAARIDRRGVYRDTVRIAYDSAFELITRLGYPQVLRMWNLVGGIIDDNADGLEIYRDFCIGRAEAFDTWAGRVGRIPAATGIGTRGQDVYLYFLAGTPDAEPVHLENPHQTPAYEYPDEYGPKSPSFARATYVDGTLYVSGTASIIGDETVRHGDVLGQTEVTLANIADLIGAENLDRHGVSGGFTLADLDQVKVYVRDAADIPLVKARCEEAFSPDADVVYLNVDVCRPDLLVEIEGIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T334</accession>
    <name>A0A7W7T334_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31806" checksum="48A85D9742D626BE" modified="2021-06-02" version="1">MVEEMSVEVVISPRGELPAEGSAEEVDWESYGASVVRVFEAVARAAFVTSLEVTWLLLPGPLPERLGWLRLGAEVTVEQATELLVGMLIGKGPYCRLVGARQFTAAVDWDGIVLLLVPDDVAERAGDLGDDEACVEFCTPSLSTWEAPGDLVTAAADSGFWERVRVAGGELVLVREDWADGRYGTRWFRVTAENVDEVAGAVWRRSRVTVVVDPVLFPAAALDDYFTAFPDVLTPGELRHCTYQEGVEDVSEVTDEGLSLMLPEEAMGRWVVVVPDADGVVRGEWLGFMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T370</accession>
    <name>A0A7W7T370_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ORF">F4559_003126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="24193" checksum="FA3735026D880F59" modified="2021-06-02" version="1">MSGDRGRYPFIAIEGTDGSGKSTLRTLLNRALAESGHRCFMVGQHSWLDVAAGRVIQAARNQQLGFGRDELTRAYAVDKFLHLRENIAPALDTVGVLADRFVHSDVVYHDVLYGIPAARTLDHHRELGTRMPDVVLFVDTDPDVALDRIVKRNKAVRPHETQRTLRRLHAKYLEFFATGVPSVARIDNNGSDPTRAVAAALRAIRRHFPAAKEVVPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3D0</accession>
    <name>A0A7W7T3D0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16594" checksum="D18D6B795FCF654F" modified="2021-06-02" version="1">MEWLDEREAAMWRSYLALHRELLGALERRLERDSGLSNADYALLVPLSEAPDGLVRARDLAASAGWERSRLSHQVARMEKRGLVVREVCAEDARGSMVRLTPAGRAAIESAAPGHVTAVRGLLFDALSEDEVETLGRVFTRVLDRLADQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E1</accession>
    <name>A0A7W7T3E1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arsenate reductase</fullName>
            <ecNumber evidence="2">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16330" checksum="289D47BE33CDED20" modified="2021-06-02" version="1">MTPRPSVLFVCVHNAGRSQMAAAWLTLLAGDRVEVRSAGSAPADQVNPAVVEAMREVGVDISAQSPKILTYEAVRESDVCVTMGCGDACPVFPGKRYLDWKLDDPAGQGVEAVRPIRDEIKARVEGLVAELLPADTTVDAVGVRSVPGASGLRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G2</accession>
    <name>A0A7W7T3G2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WXG100 family type VII secretion target</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="10727" checksum="303065FCD70DBF87" modified="2021-06-02" version="1">MADVNIGYDGLQRAAGQLRAGYGEMADRLRALRTMIDQLVSSEFRTRLASGRFQESYQQWTSGAENMISGLEGMSGFLDDVAREYQDLDQRLAGGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I3</accession>
    <name>A0A7W7T3I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="2">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33545" checksum="D2D6633D3CAC86F1" modified="2021-06-02" version="1">MTSYDVLAEVYEWLISDAKSTPPEFAAAFADVTCLLPPNAQVLDCSCGTGQLAVGLAGLGMRVVATDASEAMVRRTEELSEEFKASVRTVRADWQELPDHFDDGTFDMVFCVGNSLHHAAGARGRLAALESMSRLLRRGGRLVLTSRTWELVRARGSRLDISDRLVRRNGRDAMVVYRWEIAPHWEEEHHIEIAVAQVDAAGPVVVRSELLSCWPYRHDELEAELHRVGLRTERSTFNPEAENYLVVASKILTTGSQPLGRAARLLSADFLPSSAMPVRFRPSAHSPSRSTNPDRDTRPLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3K9</accession>
    <name>A0A7W7T3K9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_003277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030909113" description="SSI domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4965918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14845" checksum="4AC40068EF2A9374" modified="2021-06-02" version="1">MSIRSTVVACVTVTACVVLAVPAQAAGVRIGSPTPKAVGPAKYTLMLSGADHTWSRAIKLNCPTDVDGHLHPFGDQACADLASVDGDPGRMHRAQVKCTPEYGRLTASLSGVHAGRTVKWSRTFRDECALYGATNTVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R6</accession>
    <name>A0A7W7T3R6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9047" checksum="477B8473B598B603" modified="2021-06-02" version="1">MFDKAARLAGHPSDYSVSQAMGVNRSTVTRVRAGTLHPGPAFIAGALRAFPPLTFEDLFECFTDAPPARPGPSRRPENGSSAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W1</accession>
    <name>A0A7W7T3W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="34474" checksum="31BAB6B0F14B9023" modified="2021-06-02" version="1">MSPYAKYALRRVLQSVVVVLLAYVFTFVVISVLPGDPVTNTLRNPQNGFTEEEIARIVGYYGLDRPVHEQLWQSLSRFVVGDLGVSLRSDLPVGRLIGDVLGSTLVLASSALAVALVLAFAIGLGTRYLPPRYAGVLRAFPSLFLSVPNFVIGLVLINVFAFQLGLFRVIDAEGGAATFFAAVALGIPVSAQVTEVLVANLDHESGQEYAAVARSRGLGRTRLFLRHLLKPSALPVVTVVALTVGELLGGALITEQIFGRAGVGSLVQRSVTTQDLPVLQAVVTLAAVVFVVVNLVADLVHPLLDPRVRLGEARPRPRAEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T414</accession>
    <name>A0A7W7T414_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="6934" checksum="994199B39350AFF2" modified="2021-06-02" version="1">MDFSRSNSLTIRQAAWLLGCGEAGVWRAVRTGVLPTVAGRGRGGVRVPVCAVARLVESPERGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T473</accession>
    <name>A0A7W7T473_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="34" mass="3586" checksum="A54F02FC4A935B55" modified="2021-06-02" version="1">MRMHCALSTLVRLAATCLLVGFLVGGFFAVAVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T474</accession>
    <name>A0A7W7T474_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32458" checksum="6302DCC7B6A49417" modified="2021-06-02" version="1">MPADRLSHVKDEYLPSEKLDLAVEVARAARRPLLLYGDPGSGKSSLARYVASRDSLRYYDHVVTSRTTARDLLWTFDSVRRLGEAQVSGADIEPARYVHPGALWWAFDRDSAASSANPHEPYAEWNSGRAKAGAVVLIDEVDKADPDVPNSLLVPLGDRRFDVSDLPVGNREIAEPDSCASLVVITSNEERDLPAAFVRRCVVYRVPPHDRQALRQIAAKRFPGSRFPLDHLTDALLSARNSAGDDRRRKPSTAEFLDAVRACVTLGITDTGHPGLGDVVSLAIRKDPGRENEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T497</accession>
    <name>A0A7W7T497_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="407" mass="44727" checksum="002C3B7B0A2A716A" modified="2021-06-02" version="1">MVAPALSPPLFGPDYYQNPYPAFDWLRIHSPVHEFRFPAGDVPTFFVSRFADVKALLADNRFSTAGASWANDAARAAGLVFGEGTVVESIVTVLDPPDHTRVRKLAMGAFTPRRIAQWQETVERITERALDRLAESGEADIMKFAATIPAEVLGEVLGLSLEKFQEVLHAIDRAFSTDPDLEDDRKRAFNEVGEYGRELIADKRRNPGEDLTSTFIAARDGDDRFGEPELLAMISVMIMAGLDTTRGVIGSASLALIDFPDQLKLLQDNPELAPGAVEEFLRYEGALSTTLFRFAKEDAEFNGVFIPKGSPVLASSLSANRDPEQFEAPDRLDITRTGVRHLGFGHGLHNCLGAALARLEVGTSVPALFRRFPQLRLSVPREDVRWVESWLVRSPAALPVELGPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T498</accession>
    <name>A0A7W7T498_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="21801" checksum="2614339CE42CA0E5" modified="2021-06-02" version="1">MNDQAIRHWEAHYAHHVVESPTVNPRLAEIVGPLTPGTVLDLGCGSGGDALWLAARSWRVTAVDLSDTAVHALRLKAERAGVDVTALRVDLAEEFPAGTFDLVSAQFLHTPFDLDRAEVLRAAARALVPGGLLAVVDHGSTAPWSWNQDPDFHYPTPEEVAADLDLGPEWTVERADSPTREATGPGGQRATVTDHVLLVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B3</accession>
    <name>A0A7W7T4B3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein/acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1512"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1668" mass="173773" checksum="ECC0D874F173BE67" modified="2021-06-02" version="1">MADEDKLRDYLKRAIADARDARRRLKEVEDSAHEPVAIVGMACRYPGGVSSPEDLWRLVVDGVDAVSDFPDNRGWAADLYDTDPDSVGKSYSRRGGFLHDADQFDPGFFGMSPREALAVDPQQRLLLETAWEAFERAGVDPRSVRGSRTGLFTGVMYNDYGSRAHLPGRDFEGYLFSGSAGSVASGRIAYALGLEGPAVTVDTACSSSLVALHLAVTALQRGECDLALAGGATIMSTPVAFVEFSRLRGLAPDGRCKSFAASADGTGWSEGVGLLLVERLSDAVRNGHQVLAVVRGSAVNQDGASNGLTAPNGPAQERVIRQALARARLSTSDVDVVEAHGTGTTLGDPIEANALLATYGRDRAGEPLWLGSLKSNIGHSQAAAGVGGVIKMVQAMRHGLLPRTLHADEPSPHVDWESGAVSLLTDARAWPEVDRPRRAAVSSFGFGGTNAHVVLEQAPPAPEREVSAEPEVVPWVLSAASAEALRDLAARLADVAGSPADVGSALATGRAALDHRAVVVGTDRESLLRGVASVAAGTPAAEVASGVAASGGLAFLFTGQGSQRVGMGSELAAAFPLFGEVFEDVCSRFGVGGASLLSVVRSGENLDLTGFAQPALFALEVALFRLVESWGVRPDVVVGHSIGELAAAHVAGVLSLEDACRIVEARGRLMQALPSGGAMVAVRASEDEVLPLLAGRSDVGLAAVNGPESVVLSGAEDTVDEVAGLLAASGRKTRRLVVSHAFHSSLMDPMLEEFREVVRDVRFAEPVIPYVSTVGEGLSWTSPDYWVDQVRQPVRFHDAATRLVGQGVTKALELGPNAVLAALLPEDVTAAPLLRADRPEPTTAVTALARLHAAGVAVDWHAYFGDRHRVELPTYAFQRRRYWLDPATSGHGHPLLGEPVAVARSGEVLFTSRVTADRLPWLPEPFGTPVLPGAALVETVLRAGEELGAPALAELTVHAPVALTGPVRLQVRVGAADGDGRAVTVHARPDEDRAEWTLHASGTLVSQEKTADAVSGPREEYAVDADDAARYGLHPALLAAALDEGDRLAHVWQDVRLHATGASAVWATTTPAGGLELVDAAGAPVASVGSVGFRAVEPTEVKASPPLHEIRWTALPADVAEHTLTWASIDDPAGADVVVADLRSVTDDVVTSVHEATAAALDLVRRWAARDDGSRLVVLTRADDLAGAAVTGLLRSVRSENPGRVSTVALGDGEIPVDVIAHLVAADEPEAEIRSGVAHVPRLERLTGTPTGHDGWTGPVLITGTGALATTVAHHLVTAHGVTDLLLVSRRGIDAPGAAELRDDLVALGATVRVEACDVADRDALAAVLAGTSLSAVVHTAGVLDNGLAPTLTADRLAAVLRPKVDGAWNLHELVGDVKAFVLFSSVVGILGGPGQANYAAANAFLDALAGHRAAAGLPATSIAWGLWAHEAGINAHLDEVARNRFVRDGFRPVAIEEGLALLDATLASGRPAVAATPLAARPRATRRAASTGTVADFPSRLAALDPAARGKVVLDLVRTEAAAVLGFPDAASVPADRPFQELGFDSLTAVDLRNRLGAATGVPLPATAVFDHPTSNGLAAFVLGVVAPAGKSPVLAELDNLEAALADAARQHDDKEHAEIAARLRTLLVRLTGVPDEPDDEPSDVIASATADEIFDFIDNQLGRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F6</accession>
    <name>A0A7W7T4F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Malonate-semialdehyde dehydrogenase (Acetylating)/methylmalonate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.18</ecNumber>
            <ecNumber evidence="4">1.2.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.18" evidence="4"/>
    <dbReference type="EC" id="1.2.1.27" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018478">
        <property type="term" value="F:malonate-semialdehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="17"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="497" mass="51919" checksum="371D135FAA008D0E" modified="2021-06-02" version="1">MSSIVGHWIDGTEVTGDSGRTSDVFDPATGKLARRVALAGPDEVERAVAAASAAFPGWRDTALARRTRVLFAFRQLLDESADALAEIITAEHGKVLSDARGEIARGLEVVEFACGIGHLLKGGHTENASTGVDVHSLRQPLGPVAVISPFNFPVMVPLWFVPVAIAAGDTVVLKPSEKDPSAALFLAELWRKAGLPDGVFTVLQGDKVAVDGLLDHPAIKAVSFVGSTPVAKYVHQRASAAGKRVQALGGAKNHMVVLPDADLDLAADAAINAGFGSAGERCMAISALVAVGPIADPLVAAIADRARALRTGDGRRGCDMGPLVTAEHRDKVAGYIAAGADAGATVVLDGRDVVPDADGSGFFVGPTVLDHVTPDMSVYTDEIFGPVLSVVRVDTYADAVALVNANRYGNGTAIFTRDGGAARRFENEIEVGMVGINVPIPVPVSYYSFGGWKDSLFGDTHAHGAEGVHFFTRGKVVTSRWHDGGPRGVDLGFPRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R9</accession>
    <name>A0A7W7T4R9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">13-deoxydaunorubicin hydroxylase</fullName>
            <ecNumber evidence="3">1.14.13.181</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.181" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="394" mass="42477" checksum="FE0E41C75364B424" modified="2021-06-02" version="1">MTTLPPVVDLPLRRGERDLLGDLTRLPASGPVARVRHAGGLVWIVSAPALVRRVLADARFAKNGRHAPPWFVDESGLIGSRETAPGDIVTSDGPEHLRLRKLHMLGLSPGRVRAWAPTVAAVTEELLDEVGRADGPVDLVSALAYPLPLTIICTLLGLPRAVHPAMRDAAERIFYGGDADVRASGRADLYGTVARLIDEEPDRIADGLITDLLAVTRLDPPQATRTEVKAWIPSLILPGHESTASLISATLYELLAAPDRPGIATAVEETLRVHPPFPLATWRFATADLPLTDDVTVPRGTPVLVNLAAANRDHAVHPDPDRFVPDRDPIEHVSFGLGPHYCVGAALARLEATTAVDAFFHRFPRARLAEPGIPPHRESDLLSHRITTLPVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X5</accession>
    <name>A0A7W7T4X5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="419" mass="45496" checksum="536803AE469AA537" modified="2021-06-02" version="1">MTATTEFGLPTVVVTPGQETSTTMTVRNDSDIVEAYGFEVVGECAPWTVVEPERLSLYPGTSGQVTVRLRPPRSPAVRAGERPLGVRVLPTERPEAVVVGETTVVVEPFAEQQAELVPERRRAWRSARYHVALRNAGNTPVSLTVDAPEADDRLAFSLPRQPTPADPGDRAEAEVRVRVAKLLWFGKPEHWPLRFEARTDEDRHEVEGELIQLPILPRWLLALLGALLALLLLWLFLVRPAVRSAAREAADDRAQEIVQAEHDQPLPGNENQPGQGQNPGQGQQPSQGQQPGQGQQPGQAGHQQWSQTIEVHTAAGGQGTGTYVVPEGKVFRVTDIVLGNHQGDEGVLTFAFGDRTITPIALETFRNQDYHWVTPIDIPQGASVTLTVTCGKPGTPASGQQAPDCFQVANVSGELGDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T531</accession>
    <name>A0A7W7T531_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_003775</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014143">
        <property type="entry name" value="NHEJ_ligase_prk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02776">
        <property type="entry name" value="NHEJ_ligase_prk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="14">
        <location>
            <begin position="103"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4966416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="612" mass="66794" checksum="C8A9609946384FDD" modified="2021-06-02" version="1">MSVPAWVAPMLAVDDGGRLPVGEAWAYEYKFDGYRAALRVGVGGDTVLTSRNGLDFTGEFRALVGAAEVGRDLVLDGEIVVWRDGRADFELLQERRGRFRKGKSVEEFPVRFLAFDLLAFGGTSSLDLPYDERRRLLLDLPLPDDRVAVVPALSGPVEDLLDRAAAEGYEGLVAKRRDSRYLPGKRSDDWRKHPFTRTAEVVVCGWHPGRGSFAGVVGGLVLGAYDPASGDLVHVGDVGTGFDTRERARLRDRLAGLERATPPFPVPPADRGARWVEPVLVGEVRFRHRTRGAGRLRGTSWRGLRDDRTPDEVIMPSKPAETRVTVRVGDRTLKLSNLDKTLYPDGFTKGEVIDYYSRVAPFLLPHLRGRPVTFLRFPEGVGGENFFQRNAGEGAPDWLTTVVLPSDASGTVEHALVDGLPALVWAANLAALELHVPQWTVDDVRLPDRLVFDLDPGPDTTVVECCRVAERLHAELTADGLVPVAKTSGSKGLQVYAGIRTADPMAPTAYAKAIAGKFTAATPRQVTATMAKAQRKGKVFIDWSQNNPAKTTVAPYSLRGRAEPTASTPVTWDEVHACRDPEDLVFTADDVLDRVAEHGDLFAAVAGRTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T534</accession>
    <name>A0A7W7T534_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="757"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="800"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BTAD" evidence="5">
        <location>
            <begin position="99"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="920" mass="100292" checksum="0C7469A9C0E96FB5" modified="2021-06-02" version="1">MTVEFRLLGAIEAYVGGRPLDLGHPRQRGVLAVLLVEANCFVTTGHLLDCVWGEHQPVRGRNTLYSYLSRLRLALESVDGVSLDRRSGGYQLTLDKQCVDVHRFHRLVAEARAADDDRASVLFERALALWRGEPLAGLDTLWAAEVRATFEGEFLAAELDYIDIALRLGRHAEMLPLMSARARRHPLDERGTAQLMLALYRNGRQADALEHYRRLRTRLVDELGAEPGPELRELHRRILRDDAGLEASPRPVTAADPPPERPAPDELDRAAEELATAVFRQWTAEVELRSLQRPEPVQVRWAGTGRPVAASDSAVLGGRRDGVQRLDLRGGLTDLVSGFRRLPARQLVVLGEPGAGKTVLAILLALGLLADAGKGEPVPVVLPLSSWDPVRQHLHTWLAGKLLEEYPGLGNRAVYGRDAATRLVAEGRVVPVLDGLDEIPPALHAVAIDALDQAMAGARPLVVTCRGDEYEDAVRDSGAILARAAVVEIDPVGPDDAIEFLTARQRQGDTRWQPVAEHLRHRPGGPLARALSTPLMVDLARVAHADPAADPGELCDDSRFPDATLVEEHLLDAFLPAVYAQRPAPPDTRPAARHQPEQAQQWLTFLARHLRDGRSRDFAWWHLVSAVSPPTRALLLGLPPGLLCALTSWLAGGVTVGVVSGATYTVAGCLTNALGRRSGPRRVEPRFRGTRKGFLWRFGLGVAIAIGLSFGWSLTPGVVAVLAVVFGLSLGVHVWLDVPVDATRVSSPRTVLRQDRAAVLAYAVSFAVSLGLFFGVVFWFNGEAPANEPDDLFDPVRGTACLLTAALFGYFLFGRLGSVVYALPGAAIGGQVRYEAVLPDLPGAVVCGVLFAVTIGLSVLVSRPWGAFVVVRAWLWCLGRTPARLTRFLDDAHRRGVLRQVGAVYQFRHARLQDRLARDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T564</accession>
    <name>A0A7W7T564_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="481" mass="52261" checksum="A70D2AB7196D3D48" modified="2021-06-02" version="1">MNRENSLIDVIIAGGGPTGLMLAAELRLHGVRVVVLEREPAPTPHVRALGLHVRSIEVMDQRGLLERFLEHGTKHVVGGFFAGLAARWPEGLDTAHSYVLGIPQPVTERLLTEHAVGLGAEIRRGVELVDLAQDDDGVTVDLADGTGLRARYLVGCDGGRSTVRKLLGVAFPGEPTRVETLLGEMELTTPADEVTAKMLEVRKTQLRFGLGSLGDGVFRVVVPADGVSEDRGVAPTLDDFRRQLRAYAGTDFGAHSPRWLSRFGDATRQAERYRVDRVFLAGDAAHVHPPTGGQGLNLGLQDAFNLGWKLAAAVGGQAPEGLLDTYESERHPVAADVLDNTRAQMHLMSTEPGPQAVRRLLSELVAIEEVNHRLIAKITAIDVRYFGDDDSLVGRRLRDVELKHGRLYAHLHAGRGLLLDQTGGLSVAGWADRVDHLVEVSEELDVPAVLLRPDGHVAWVGEDQRDLEAHLPTWFGAPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P9</accession>
    <name>A0A7W7T5P9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DeoR/GlpR family transcriptional regulator of sugar metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26674" checksum="ACFBA2FEC36E7A6D" modified="2021-06-02" version="1">MLELLAERGRIEVEDIAAELDVSGATVRRDLDHLAGQHLLTRTRGGAVAHAVAYDLPLRYKTVRRSGEKQRIGRAAASRVSRGEVVGMNGGTTTTEVARALMTSAEVGGAEGDGLITVVTNALNIANELAVRPQVKLVVTGGVARPQSYELMSPLAGKILSGLSLDVTFLGVDAIDPDAGVSAHHEGDADINRLLAERARRVIVVADSSKIGERAFVSICATAVVDVLVTDTEAPPEAVRRFRERGVEVVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R3</accession>
    <name>A0A7W7T5R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5515" checksum="3BBA887FD6080ECB" modified="2021-06-02" version="1">MSATPIFDELAAMYLAEMPDSRERLAAMAAGLPLPSIPLPSPPIPEPVPSSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S3</accession>
    <name>A0A7W7T5S3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14918" checksum="D9BB8739EF68C8D6" modified="2021-06-02" version="1">MMCSLLPHVENSPALTTFVKAQAGLTPVLPQLTGKVVPRMVGMESRPNWANVATVPMLWLEAITSELIPRSLANLELAGPMTNQRPTPVGELVDARRDDGRRAMEQLAEHAGEESAHRIKTRWAACLPSPPTAPGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y8</accession>
    <name>A0A7W7T5Y8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">F4559_004551</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="17837" checksum="AE4BD9A8BDC14C05" modified="2021-06-02" version="1">MKLDRALALLREVPDFPRPGVVFRDLTPLLADPDALRAAVDALQDTIDPATEVVAAVESRGFLIGAALGYGWHYGVVPLRKPGKLPAVAHRVEYSLEYGSAALELPAGALSPGQHVVIVDDVLATGGTARAACALVESAGAVVTGVAVLVEIAGLGGRAHLSPTPVSALRTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C7</accession>
    <name>A0A7W7T6C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar O-acyltransferase (Sialic acid O-acetyltransferase NeuD family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="21780" checksum="8253462A0D39104C" modified="2021-06-02" version="1">MTPRPLLLVGGGGLAREVLAAARLRPDEWKPVGALDDDPARHGADLDGVPVLGGSELVHERTDAAVLVCIASARRPLGRLAVARRLGLSEDRWATLVHPAASVADGAVLGAGTVLLAGAVVTTPLRLGAHVVAMPHVLITHDDVVGDGVTFAGRASLGGAVTVGESAYFGQGAAVREGVSIGAGAVIGMGSAVLTDVPAGEVWAGVPARRLREGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6H1</accession>
    <name>A0A7W7T6H1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="554" mass="58139" checksum="DA940C6B671B2232" modified="2021-06-02" version="1">MTAPETPLASPPGMDITEENKFKGSMFVEAFDGLIDSIGSDAESETERVLDITFNAIGAASSVAMIVTDPFGSILGAGIGWLIEHITFIREGFDQLMGDPANIQANVEATKRQAAEIRVLAEDHKQGLATFDGWTGTASERFQASMTAMGQELDDLAGAVETKAKVVAVTGMLVTVLRDIVRDMIAQFLGSLIGGALTAAAAMVPTAGASIPAFIGYAVGRGVALASNIASRIAKLVGALGRNLGRVGKLDDIVKMISKGWERFENIADVAEIAWEGVKAVGDVDETIGKAKKQDDDQDVVDKANNDAKAANQQYEDAKEAEKQQAEEAKAANEKLNDSTKKLSDANEKVDDAAEKVNKAAEAGDKEAFDKAKAEYDAAKAEADAARAEAADAADTAAKEARDLSDASKNSKEALDATKPTDDAAKQAYEDYKTKNPGGQEDPARAADESDLSAKNDAAKASNAKYEQANTEYTEANAKAAEANAKALRTGSEADIAAAERASRDAEAAGAKVESAATEAKTSGEAAKKSYDDYKAKYPSGERETKSDAPSVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L5</accession>
    <name>A0A7W7T6L5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA invertase Pin-like site-specific DNA recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="28"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="491" mass="54932" checksum="38E124EF2AC32FF0" modified="2021-06-02" version="1">MTVDEIFPKALQADRRYLIEGNDSRQLCVFYLRKSVGDDFATQVLRCLQFARTAKMRLDIAVGNEGVYYDDDKSGSKAIERPGYNALMTDIITGRLSGRSIIVRDQDRLSRRESSVLEDYHITTEMGKVRTYDSSGREIRDDVVTGIMGVVSRNEAKKTGYRQRIRKELRAIEGLPPNGGQRRTGYTSQYDAIVWEEAKMLRHARRKIVAGMSSYRVVKDLKRMGYTKPNGKLYSVADIGRFLKDPVYAGLRVFSRDIVIEGRTIPKGSVVAKGGWPKIFTESEHYEVAGIIGKNKKWSGEGKVRHLLTGILVCGQCGTKMGYGPKHGGRRKDGSRTMSHIYVCLVGKGGCGNVSRNAKVLEAFFVGLTYEALKRLPVEPVRPEVDTTSIEVERQQKKIADAVQAFKDDRIDIGELADIRQDAQAKIAAQRKIAASKPQRSQLGDADEFLNAETLAKRDVIRRLFPVVGVRSGGKGVRFDPDQLIFPESMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T4</accession>
    <name>A0A7W7T6T4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding Zn ribbon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="1">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19332" checksum="057917611FFEBE99" modified="2021-06-02" version="1">MDVLAFVGTVRFDGQNGFLDDLDTPEGFAAWSGSAPDEDLRQRVVRLRWATRSLLAHLVDAPDRADTPLLLAPDVATAVLNDAAARVPRYARLEWATRPAMRYVDAADPADRFVAGLATAAIEFLTGGERERVRACPAPRCVRFFVKAHPQQQWCAPACGNRARVSRHYHRVHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A2</accession>
    <name>A0A7W7T7A2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="92" mass="10392" checksum="23253FB176771116" modified="2021-06-02" version="1">MTGMVSGFLNTRAIRRYGEFVGALDMVEEAFRAVDEVIDRVDDSESGCACGWTLPTRDDLVALRRRAFEALDSVRLKAKKHEGDLVSREWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G0</accession>
    <name>A0A7W7T7G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="493" mass="52713" checksum="DB5324FC479D5E5D" modified="2021-06-02" version="1">MVAGRGGPEPWRLRLVDGTGSVLGAGVQLGTRHVLTCAHAVFGLAHTLAGRVGAAPVAARVVPGWWVPPGPDGRGDVAVLELDEDLPAAGAVLRRTALSFDRLVHTYGYPDARGDGVWARLHLAGRTGPGAEWLEMRGRTAAEPRLEPGFHGGGVVDDRTGAVLGIVVKRDRTDGSTRSWLSPVETIVAHVPDVARWVTGESAADKVFSDRLDPAVELPDVARALADWLDRAALGDLVITVAGADRHELYRLVSRADRESRRADADRVGGIDLAVDASGRTPEEVARRVVARTGIDVEAGVRSSDLVRAGVPAMTVVVDAVDDATDPEALLADVLRPLAAHGTRLVLGYRRASSPALDAARAWEVDQRLGCLSRWITRGGRFDERTTGLRRRVTAIRGIVREFGVEKARDRLDRLTARVAALPVDPPDERRELRGLLEAYQAKAHRAGLAEDPELTALYRVADHALAATPFDPGAAGNAVREYGLAVGRRADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7J7</accession>
    <name>A0A7W7T7J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7108" checksum="2F68D98F39FB1A8F" modified="2021-06-02" version="1">MNAFDKATKLAGYRSDYALSQAMDVNRSTVTRVRAGELQPGRAFIGGALVALAPMQFDDLFEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7S9</accession>
    <name>A0A7W7T7S9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="4">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mtnC</name>
        <name evidence="5" type="ORF">F4559_005503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043715">
        <property type="term" value="F:2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043716">
        <property type="term" value="F:2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01681">
        <property type="entry name" value="Salvage_MtnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="23796" checksum="F6F0289D96BBF864" modified="2021-06-02" version="1">MTEWVVLDIEGTLSATDQVLVVLYDYARPRLGPWIDEHASDPVVAEAVAQVRELSGVTGGTDELVAVLHGWMDADRKVTPLKTLQGLIWQRGYAVGDLVAEFFPDVVPTLRKWHEDGVKLAVFSSGSVAGQVAFFGHTTDGDLRGLFEHHFDTVNAGPKREADSYHAISAVLGSSDVTFYSDVPAELHAAAAAGWQTVGVARPGEPYGEADFSPHRTVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T7</accession>
    <name>A0A7W7T7T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SARP family transcriptional activator/Flp pilus assembly protein TadD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="756"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="970" mass="107304" checksum="7577B32F706240AB" modified="2021-06-02" version="1">MEFTILGLTSLRIGVIRHHLGARKQRALLALLLLHAKRSVPVETMIGILWPDHDPDRHRGNLQSLVSRIRRVLGNAGVDFALSNEGDAYRLDLDLRLVDYHRFLKMADSGRAEAAAGNHPEAKRVLTEAIGLWRGRPLADLPGEWAAKRRDFMEENDLLHAYHALFQTGIHLREYAEVLRELRPLLDRHPYDDALAGLWMTALDGLGDRHAAIAFYSQFRRRLTGEFGTDPSTELDRLHQRLLTKYTVDPGPTSRPAPDTRTYRFPREVSAFAGRSAQLDRLDSFLAASHAPQGMPLVTLHGMPGVGKTELAVHWAHRRRADFPDGMVLLDMGGHGGGEPVTPDNAISLLLGRLGIPPHRIPAEPDRRAAVLGRVLADRRTLLVLDNVRDAGQVRPLLDSTSAAFMLLTSRDRLRSLAIRDGAHTVAVPELTTDESLDLLRSTIKDERSPRDDAGLLELARLCGGLPLALKITGRHVADRPRETPGQLADQLKAHRDLLFRHEDDESISLRSVFSWSYQALSTDTARVFRTLGLLPGTRLGSEAVAALTGLTSTVATKHLDALAHVNLLDHDVVDRYRMHDLLHDYAATCAAETDPDEERNVAVERLLTWYAVTCSAVSRQLSPQSPPVPELPDVGVSPLSFASDQAAMEWCAQERANLVAATKLASANGFHDQAWRIPAGVQEVFERSGYHDDLLASHEWALESAHAVGDVEARLGTLNNLGVMYLNVQRLDDALRHLRQGLDLARSWGHEEGEAVCLHNVGRAHFGRGEIDVALEYYRQALAINKRLGGGEGEAFGHHGIGLAHLSLGNLAEAKANFAEALRLRVEINHVRGQGTTLTALAELHHDNGELDEALDYCRRALDAHRESGDRKETCHALAVLARIEFDLGDFRGAYERASHAAELAHELNDVHTQARSLHLLGHIDIASGRTRHAVIRWQQALSLYTSIDAPERLAVQEHLEALHYDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U4</accession>
    <name>A0A7W7T7U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="432" mass="45745" checksum="182AA1B251509949" modified="2021-06-02" version="1">MSDEGPKNITELNPLNATEGFKTDDLAGFSNFDSPTQAWDASGIFGSAANTIYDGVKGDWGAVAGDLAGVGMDLLGFVTNPLGSLLSAGIGWLIEHIGFLKEGLDLLAGDPDAVTAMATTWSNIAKRMRETSEKYSDTLDTLSGSQGAAIDGYRKAVQDFSNVVSGGAGHATSAAQAMTVAASAVGIVRGAVRDAIATFVSNAIIKFAAATALAPVTFGASQAAFIADTVAQGAITAGKNAKKIRKVVKQLEKVADDAKNSRNMLKGTTRNLEKTVTNYNRDAAKHANQALNMVKKAQAGKLDAGDAKRLEALGEQGEKLKGDKKDAIDSLAGTRNDNLRERMGTGDPRLDNAGDMLEREISLGPGRPEVGLPNCPKVLGNAAVQEWSDQTHREADAQVKQDVKDEAWRTYWEEQRENAGTPDRFQRMEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U8</accession>
    <name>A0A7W7T7U8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9608" checksum="B6C6888C8717D991" modified="2021-06-02" version="1">MASIAWTVGDGRQSRSDSPIDPSSKTPDLGERMVKSQVDVAHPAMATRCPGDGVRPDRPNQHGYGYPESVVEHGILGFVPFEGRECLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T806</accession>
    <name>A0A7W7T806_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR02677 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013493">
        <property type="entry name" value="CHP02677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09660">
        <property type="entry name" value="DUF2397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="490" mass="53168" checksum="AE0FBFD719163C02" modified="2021-06-02" version="1">MEPARLKLYAYLDAREHQRTYLAIMRLFTSTLLADLSAGEVAGALAGVERRGGVEPGESRIENVINRLRQLVDWGNLVQGRREVVASSIAEFQHGSVRYQVHKLAVRVQRDVDELLRVPEGAREVSRELLPAVERGLGVLGESLSAALVDGSRRPRELVAEQVTTLFLQHAELAATVRDFYAYLGQVVTRHHLAPDEISGFRDLLVEYIGMVVEDVLRHTPAIARALAGLAAARSELLRVLGTAGLDGRVERARGRSAADWRELTDWFVDRPGRPSQVTALREATARAIGSLLAGVKRATSGGALLPGRRAELLKLARWFDEATPDGAHALYAAAFGLYPARHLSPAPEHDSDNERTRWSDGPVQEVSVSVRGRGDRGARGRPARILDDPMTEQSLLAQAREADGRRAASVAELRSAALARDTLSPGALGVLCELLTLAMAQRDSDRDAGHAVDPVRGLRVTVAHSPGVHTKVRSAGGTLTLHDSTVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E6</accession>
    <name>A0A7W7T8E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10030" checksum="9414062168966016" modified="2021-06-02" version="1">MRKSDRWTDALASPTLHEAHVRLGKLAPPPNAAPEDRIAYHERCRDVYSKVSKVDAAHKHEATAWATCELNSATRIRNALKAEQEGAGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T6</accession>
    <name>A0A7W7T8T6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_005979</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="211"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4968620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="39094" checksum="DB7A41CCFFC2D795" modified="2021-06-02" version="1">MVRRGTLADGREIFHYFDVGSTPVPPAPDLRELPPVRVESEIRRDPLTGQWVAIAAHRQARTYRPPADLCPLCPSRPGSATEVPTSYDVVVFENRFPTFAPDVPGEVSPSRAPGRGRCEVVCFTPEHDGSFARLGPVRVRTVMEAWADRTSALGALPDVAQVFPFENRGAEIGVTLSHPHGQIYAYPFVTPRTEQMLSVAEDHLASTGRPLMGDVLAVERNGPRVIAESPYWTAFVPVAARWPVEVHVVPRRHVPDLPALSAEERADFAELYPAVLRRLDALYDKPLPYIAAWHQAPVRVGHDALWLFLEVFSVRRAADKLKYLAGSESGMGVWINDATPEDVARRLREVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W2</accession>
    <name>A0A7W7T8W2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024495">
        <property type="entry name" value="DUF2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10969">
        <property type="entry name" value="DUF2771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031189020" evidence="1">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17080" checksum="096437B0482AD014" modified="2021-06-02" version="1">MRRVTFPLLALSATVLAGCAAPAHPTVTFYADGHAIEVPPTQYCDIASENCAVDPRAAGVLRVRPGKPVQISVPGEIADSAWAVNFTYRNASGVRQEPLRSKVFTAADPRHAYTLTLPSAGDQLESVEIQQYGKRIESSALGIEFVARATWVLSVDDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T913</accession>
    <name>A0A7W7T913_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="15300" checksum="15354F80C9601C51" modified="2021-06-02" version="1">MGNEEEWPVEQTWSLRNTHWHAYVEHTSLDHASPRQERLERTPEEVLTTPTEVAAWLEVNLRSATKPEEAGKKRAKDERDFSDSHRVHTSIASAGESIYTGVKGMLTLAVEAVTPEECRSSHDGADVAPLKAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T950</accession>
    <name>A0A7W7T950_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="19080" checksum="5FF1EF18E7733B1B" modified="2021-06-02" version="1">MTEYLTKSIGDCHDARTTRQEEHAERLCAELAVTPCSPQCPVWLLYGVQPRGARVSMEPGKCKGKAHKRSTLGVAGRRVLVSRKWSGKSLADHKHDRVAFVRQLLADVGIAQDEQPRRVAWHNVRPGDPNVPPRAHLLMRAVAERRRWKAEYTAALLASASPPNHSATPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I7</accession>
    <name>A0A7W7T9I7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="28090" checksum="8B28876397ECA594" modified="2021-06-02" version="1">MTERVFRLSAAEFFLLWQAAHRGGPPVPLGTRHYGFTEADRRSLEEVASRDLYQRGYGTVQRPDEDLYGLLRGLAEFQVGLEVVFNNQAGGLARGLATAAWHGAFAGRLGDVVQLSGFPPSSLAYTTVNTLPRVSPGAGRSLNVRWDDYLAAVRAGETDGPEGFLDTLRRLGMREPEMKTLMRIVTTRQGGGQVGLIARNRNGYLHNVRGAALSWLDTADGRYLLRRDRQWLVVAPVDPPRLVSAVESLIGSVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U9</accession>
    <name>A0A7W7T9U9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate starvation-inducible PhoH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="4">
        <location>
            <begin position="117"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="38229" checksum="43DD0DD9555CC528" modified="2021-06-02" version="1">MAGTADNTPQDAQYKFAVPDSAVLALLGQRDENLRLAEELLEADVHVRGNEITLSGLPADVAFAERVFSELVTLAARGQQVNPDAVRRTVAMLSAGTGESPAEVLSLDIVSRRGRTIRPKTLNQKHYVDAIDKNTIVFGIGPAGTGKTYLAMAKAVQALQAKQVNRIILTRPAVEAGERLGYLPGTLHEKIDPYLRPLYDALHDMVDPESIPRLTQAGTIEVAPLAYMRGRTLNDAFIILDEAQNTTPEQMKMFLTRLGFGSKVVVTGDVTQVDLPGGQRSGLRVVREILEGVEDVHFSVLTSHDVVRHRLVADIVDAYEKWQVAVAETEEHEHHTGPGGRARQQRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W4</accession>
    <name>A0A7W7T9W4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="632" mass="65977" checksum="399882CB58258280" modified="2021-06-02" version="1">MGRYALLVATGAYDDVRLARLRSPASDVERLAAVLEDPDIGGFTSVTVLRDRSAGEIRLAVEDVLDREPGDLVLVFFACHGVMTAGRRLHFAASDTNLDRPAATAVPRSFVHEQLADCAAGARVLVLDCRFGGVVADPVVEAGEGYVVLSATDAFGQDKSVYTDVLIEGLSGGAADLDGDGWVEVAEWAAYAARAVGDRQTPLFFPDGTAGAIRIGRAGTGVVRVAPTATYTPRQLLVARGFRAVADRVCRTLGPYGRRAVLYVDRAPVEAGDASTIVDVFKPDDSRDLLGVEYARDLVREVRSEAGDGGASAVAVTSDAVDGLVDAMRSGAHPIRLLHGIETAARRAVELIITSARDLVLGEVGALAGGVVGSAEAADVIVRVADLIGLNASFLVDVEPGAGVDFVLRMGARFRHAAVIGEVPDQGRVLLLAGRFNGRIAEEPRIGLVVCLDVNRSALKSDGPGVVVVSDPDVLNELRLLVGGQVLPGAKVDRPYGNATRIVVSEQEILVLGNGEGRPVAVVRTGSAAEAGRLERAARVLRGAAEDGVLRGQGIGLRAVGGLVTRSAVGETEEELGIQVFGRALGAVARWVAENSALDVTGLDASSVDSAVVARVVVEASARTLRRFLLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA42</accession>
    <name>A0A7W7TA42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11442" checksum="D285EBDA7E07C6AB" modified="2021-06-02" version="1">MSEPVARHDRLVRFHEEALPLVAGLAGRISDDDLDSLEGLGEAGEWGFFFDELSALLHRSRIGITPAERDVFVDLIGLFTLPTGHDFINDRDEVVASLNVREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA57</accession>
    <name>A0A7W7TA57_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase-3 subunit epsilon</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="30159" checksum="BB5225A3EA887156" modified="2021-06-02" version="1">MGYAVVDVETTGFTRLDRVIEIAVVRLDDAGRVTDEWCTLLNPGRDLGPQHVHRISAADVWDAPTFEQAAGAVAERLEGHVLVAHNLAFDARFLRTEFARLGTDLDVDGLCTMRLASRFLPGARSLEACCAAAGVPLGSAHEALADARATASLLAYYLRRGPLGGVTVPWPRMPSDVAEVRRGQGRLTRESVSVTLTPGDLVVFTGRMREDREVWVDRACAAGLRVNHGYVTRTTSVVVAADPFSLSTKARRARQYGVPIVSEDDFAALLHAAGPEELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAI1</accession>
    <name>A0A7W7TAI1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">F4559_006908</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="67"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="183"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4969549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="37436" checksum="4FB34E7AA35968A8" modified="2021-06-02" version="1">MEQVDVTDSAKATYAAAGVSIEAGEEAVEQFKPWAAKASRPEVLGGIGGFAGLFKLRLDRWKEPVLASSTDGVGTKIAVAQALDKHDTIGIDLVAMIVDDLVVCGAEPLFLQDYIAVGKVVPDRVAAIVKGIAEGCVLAGCALLGGETAEHPGLMGDSHYDVSGTGVGVVEASAMLGPERVRHGDVVIAMGSSGLHSNGYSLARHVLLEIARMPLEGHVEEFGRTLGEELLEPTRIYAKDCLALAAEAEVRTFAHVTGGGLAANLARVLPAGHSARLDRGSWTPAPVFALIAQRGRVERDEMEKAFNMGIGMVAVVSPEDVDRSLAVLTARHVPAWVLGEVTKSDAPTALVGDHPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAR3</accession>
    <name>A0A7W7TAR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="49" mass="5114" checksum="F3B5D8D2A6F26998" modified="2021-06-02" version="1">MRTRLVNSLLVVALLGVGTAGYFVLSAEAAGRGSRRTTRCCGTRAGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCM2</accession>
    <name>A0A7W7TCM2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26140" checksum="09FF5353C60FBF13" modified="2021-06-02" version="1">MAHRGIGRARAAHPDRDFQFDVDGRRDRHPRTASQRGEYLVDLRCRLVATTDHRLDCAVGLYESAVSLSAPSLDERRWQVTPELVDPAGRGSGGTTDGGEVGGEPLVGGRQADGELLGSLSDLGQSDFALDAVGIGCAGERRGQEVDRVGEQVSGLCQRGTDLLGLVQNGMQEGDHRAECGQPHRRSALVGEEGPPLARWESDHRPGRVLRVAHQDAGRRCGHLDTGGTSLTAVTAPLPSDFDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCS7</accession>
    <name>A0A7W7TCS7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10115" checksum="0AFE0D72B3B3001A" modified="2021-06-02" version="1">MPQVDLVNSERDWFVECEKFDGAAAECLITVADGTVEVYGPSGEFCFALDETAIADYRAAFDEALSLAGRDRRERVSVSWAQTGDSGGNSSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT46</accession>
    <name>A0A7W7WT46_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease ATP-binding subunit ClpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19118" checksum="24ADD94DF5B3D448" modified="2021-06-02" version="1">MIGERLTKDARKAVRDALDEARRARASSIEPEHLLLALLDDPVLTSFQVVRADVEAAFAAARRKGGLSAADTEALRGLGIDVDRIVASVEQTMGEGALAVGPPRRRRWPRGSLPFAAGARDVLERALREARDLGQRPLRSEHLLLSLLAGGGLVEEVLAERGVTYGGIRRLVSTRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTQ8</accession>
    <name>A0A7W7WTQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="344" mass="36499" checksum="790A65171FA0B2E8" modified="2021-06-02" version="1">MSPIRLAVALDGAGWHPAAWRLPEARPDELFTAPYWIDQVQAAERGGIDFVTIEDQFGVQSPLTGPDGRTDRVIGRLDALLVAAHVAPHTRHVGLVPTANATHTDPAAIAAAFAALDQVSGGRSGWRPQLSARENDAAHFGRRPAVALTAEDVAGGPLAISLRLRPLFEEAAGFLEAVRGAHDTLVAPLAHAPIPYELAAKGADIVFVTPFSLDDVGHVLGEVREAEAKVRTRSEPLRVYADLLVHLDDTPGAADLRRRHLDGLDGAEADSDAKIVTGTPGELADLLVAWHSAGIAGFRLRPASVPHDLHAIVDGLVPELRRRGVVPEAYGSGSLRERVLSTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUE2</accession>
    <name>A0A7W7WUE2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="12461" checksum="DD5765DA27F9E67E" modified="2021-06-02" version="1">MLAELEGVSPELLDDEKFLRHALGEALTQADATVLEVVSKQFDPQGVTVLALLSESHASIHTYPEVGKVFVDVFTCGTRAKPALAVQLLADALGAVSARSDLITRGARVPALVGEEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU6</accession>
    <name>A0A7W7WUU6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Steroid 5-alpha reductase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="DUF1295"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="PTHR32251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29292" checksum="84F800B3E27B0F3B" modified="2021-06-02" version="1">MSFGWTVLWSAVTVFVLITALFGYAVSKRRFDLIDSFWGPGFAVVAVVAFALSDRAWPGLVVVVLTVVWGVRLGWHIHSRNRHKDEDQRYVDMYRRAKGNPVAKMYRVYLLQGAIMVLVSLPVQFAQSRPASGVLFALGVAVWLVGFVFEAVGDAQLARFKADPATKGQVMDRGLWRYTRHPNYFGDACVWWGLFLLACGSWWALALVVSPVVMTFLLAKGSGKPLLEKDIVHRRPGYAEYVARTSGFFPLPPRRRGPGVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU8</accession>
    <name>A0A7W7WUU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27000" checksum="413489625527D597" modified="2021-06-02" version="1">MSDPYRYPEDDWTRPSPNRSASLVGYDKALVHSILDRAYVASVAFIAPGTTGHPGDHAVALPKLYGRDGDSLYLHGSSESRLNVLARAGGPAGFPVCVTVFHVDALVIGRGAINHGVSYRSVVAYGRVSEVTDPEAKKAALATILDHVVPGSSRTSRPPDDTELGFVAVLRFDVELASAKVRTGGPDTRPEDWHSTNWAGIVPVGEVYGPPISAVDLAPGIVAPDHLHYLTEIRSHGNLGVLPPPPHRSKTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV38</accession>
    <name>A0A7W7WV38_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14953" checksum="044147B780DCA039" modified="2021-06-02" version="1">MLFAVLLSVLAALGLLVPAFTTGQDLWAWLSVGASGLAAVLLVLDRALRRRSGTTRSEVTGPGEEPGEEDTSADDLLIVAGLHDEVRVLDERPRYHLDTCPWVGAHATLPLPVSEARQLGFTPCDVCTPDVTLVARARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV70</accession>
    <name>A0A7W7WV70_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Prokaryotic ubiquitin-like protein Pup</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Bacterial ubiquitin-like modifier</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pup</name>
        <name evidence="7" type="ORF">F4559_002344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic ubiquitin-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02106">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008515">
        <property type="entry name" value="Ubiquitin-like_Pup"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05639">
        <property type="entry name" value="Pup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03687">
        <property type="entry name" value="pupylate_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="ARC ATPase binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="modified residue" description="Deamidated glutamine" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6779" checksum="7E1B32DE528A6B57" modified="2021-06-02" version="1">MAQEQVQRQGGGDGDDNGDGAAAGQERREKLGEDVDAILDEIDDVLEENAEDFVRAYVQKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE4</accession>
    <name>A0A7W7WVE4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030842154" evidence="1">
        <location>
            <begin position="33"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="17411" checksum="3466CD0D7FE488E5" modified="2021-06-02" version="1">MRKAPAVVLTTLLATVGLAAAAAPASASVADATCAGSVSSTFSPGLRANLLPPPPPATTATESAALTGCVSLSVPAITSGTIVPNGNTESGNCVAVNPTVTDVIGINWNNGTSSVVFVTDRVAVNAAAVRTVTLTGVVVAGTFFGQAAVIVFTSPLDPLDCLSASGLTSTTGVVTLAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ3</accession>
    <name>A0A7W7WVQ3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="708" mass="74201" checksum="A288BB60939B500F" modified="2021-06-02" version="1">MGTAGGLLACRYRLDRVSGRGAAGVVWHAVDELIGREVAVKELRPATDGVPGIGGPARALREARALGRISHPGVIGIHDVVTEDDTVYLVVELVRAPALESVLSEGPLSPERVEVPTARLLDVLAAAHGHGVVHRDVKPGNVMLLPGDEVKLVDFGIALTARDERLTREGVLGSTGYLAPELFDGGEPSAASDLWALGVTLYQALTGVTPFERGTEAATLHAILFADPPPLPVTGRLADVITGLLTRPVERRLTASAAVALLRRTEAWDPRATTVSSAPRRPGEARYRVIRPHPALVVSAAALIVALSSVVLVDLVLSGRLPWWTLVSVVLPSAVAGGEAHLRHLRRWWDTVEVSARGVVLSRTGDRRERVLPWPAFSRLEVAKVRTGARLTIGDVRVDVARPAAEVVRDLTGIAPPGVLVKAGVATPVPHAMPTLSAGVVFVALVRLIEVPAQREPLVDSSKRYTALGGAARADVVVGVADDRTVAVLRTRTAGAVAETFRPRGGPVDLIAVSTDGTTFASSGPDGTTIHGTASLRTLVGGARDRAAGLALDEHGRVAVLLTGEPGRRVIKVLGTDRVAEPVTITDRTGDVSAVRVVVPPGADRVEVVGVDTAGGHHTWTFTDPTDLRPGPARHRDPPADWPGGPAALTEDGRTWVVPAGPGSVRLYEPVGFTVPPGDSPSARSRTATASSPRERTEPCAPTASPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV3</accession>
    <name>A0A7W7WVV3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030853489" evidence="2">
        <location>
            <begin position="19"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21280" checksum="E1BCA423FE574E3E" modified="2021-06-02" version="1">MRVPTALVAVTAVVAANAAFVLLGASFDYPDVLGHDSAEALRAFRANPAIAWQFALLALSAALLAPVAVLTARLAGGAREALVVGCAAAVVQVVGLLRWPLIATGLSPDDPADVHLFEQLNRILGGAVGETGGYLLTALWTVLIVRRLRPGRWSTALALVSAAGILGGVVGLDKVNFVGYVLWSAWLLWFAVILLVTPRVEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW4</accession>
    <name>A0A7W7WVW4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="9445" checksum="6061BA1325A5FB2D" modified="2021-06-02" version="1">MAERGVDLAGGTVTVVEGVPQRGQLPAGVRDLLSRVGVVVGVQQVALRVAADLGANVAASSPSAPRRWTSCQVSAHTVVGPGSWSDSPRSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY8</accession>
    <name>A0A7W7WVY8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-aminobutyryl-CoA ammonia-lyase</fullName>
            <ecNumber evidence="2">4.3.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047459">
        <property type="term" value="F:3-aminobutyryl-CoA ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13263" checksum="2CCEAA366EBE1B83" modified="2021-06-02" version="1">MKPGFEVTHRRYVPHAHAHYGGDLVDGAYSLGLFGDVATELLIRTDGDEGLFAGYSSVEFTAPLRAGDVVEATATLVRVGTRSRELAFEARVVCRSAPERGPSAADVLDPPLVVTRARGTVVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA4</accession>
    <name>A0A7W7WWA4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDGSH-type Zn-finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZnF_CDGSH" evidence="3">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7695" checksum="71D55F08ECFAB962" modified="2021-06-02" version="1">MTAERATITSYENGPLLVRGDFELRTHDGELIDPGRGTVALCRCGKSALKPFCDGTHKAANFRASGGDRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF8</accession>
    <name>A0A7W7WWF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="29560" checksum="1C40256B4F51DE1C" modified="2021-06-02" version="1">MRIPQLIAVLVVGLVAAACGPDRDDAVTNGETAADTEALPTGAHELVLRMDYSPGFARVPETAPFPAFSLYGDGRIVTADIDVNAPAAPGGWQRARELRTDSAGIRRLVRAAHATGLQDTTEPSGTASTGTPADATSARFVLLDGKNGRHSRTVAAPEAHGDARGELFRALSDPAAWLGGTVQTAPYRADALAVLRRDEPASDPAARPWPVGALDFPGTRLGSGQRVMTCVVLHGESAAAVTARAADVPQYSPWTDGSHTATLELRPLLPDENDCPDLPGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM5</accession>
    <name>A0A7W7WWM5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan hydrolase-like protein with peptidoglycan-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031171675" evidence="1">
        <location>
            <begin position="31"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_3" evidence="3">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23024" checksum="AF4C5014316488AF" modified="2021-06-02" version="1">MTDTARRTVLLAVAAAPFAALLAPGATARAAGLDTLEIQIRVAGWAADEPRQVGLALTGRLDAPTKDAVRRFQGAHGLRQDGIVDERTREALTALAKPDGSTRHFDWTAFSPDGTFAGGAADEATVREHVRRLMYRLEALRHKVDGREITVTSGFHTHGGAHALGGAADVVIADSTTYAAYRAAQTCGFTELGMYTQSWLHVDILPSAFTWADGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWN8</accession>
    <name>A0A7W7WWN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator YhcF (GntR family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12628" checksum="DBD1BC7140D0FC45" modified="2021-06-02" version="1">MLITIDPTANVPLADQIAASVRGAAVRGELSPGDRLPPAREVAAALGVNLHTVLRGYQRLRDEGLVDLRRGRAAVLTDAADGPRLAVAEHVRALVEAARRAGLGEQELHTAIEDAFNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX23</accession>
    <name>A0A7W7WX23_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="28152" checksum="1337573FE7957F57" modified="2021-06-02" version="1">MDRDARGDREVSRSRVVGTTHLLDGLWHRLGHAHVLREGFARVNLPPHWERYVFAASAYLALDHHDDVSLVEWLAYDVDVPGLEPWVRLDGAATALAGAELRAVLARHSLEQVDGTVYIGRVGTGHGTVDLAMTPDGTPIRHDTNLAALYRSRPGRHRVVVVDHAADGQVADLLVAAVGTAERLYGRTPRRMHPCVGFAQLLVHTAETATGTEWPRIATQLDRVHRVEFDDGTTALTALNRRQRELFTLCAVDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX36</accession>
    <name>A0A7W7WX36_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="30914" checksum="5878C85E7BE3ED4F" modified="2021-06-02" version="1">MGLNFAQLRAFLAVVDEGGFGTAADALGLTQSAVSHAVAALERTLGHPVLTRQGRPQPTAFGQELLAHARSAVNASAAITDLAARLAGRPRGTVKLGAPTTVCQGLLPDLLARWRAEFPDVRVRLFEGEDDEVAEWLDNGTVEAAVLVDPPGARGAWIGEDVFQVVLRQDHPLAGQEVVSVDDLVDDQFLLSGGGCERHVRRISPAWAAEPVHRVRELGTLLAMVRAGVGVSIVPGLAAAMLPSGLVLVPLARRVARRLVLSGPADREWHPAVTALVESVSADFTEGRQRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX55</accession>
    <name>A0A7W7WX55_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette subfamily C protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="577" mass="61719" checksum="C18CB307816D4A85" modified="2021-06-02" version="1">MTERLPVATPRQVRRATRLMLTRGDLSWAVLLNVLAVVASLVAPWLLGRIVDAVERGDVAIVDRLALGVVAAAVAQLVLTRYARYTAHRFGERALAGLRERFVDRVLALPTAVVERTGTGDLLTRSTADVATVGTTLRTAVPEVFTAGLQVAFIVVVVFLLHPVLGLCTLVGLPALWLVTRWYLRRARPAYLAEGEVNSAVAESMAGTAEGARTVEVFGLGARRVREVDDAVDDVYRSRTRTLFLRTVLFPITDLAHALPTFAVLLVGGFGYLRGHLGLGAVVAAGLYVWQLVDPLNRILLWVEQLQSGGAALARLEGVAEAATPPVTPPSPHDDRLRVSAVSYAYVPGRDVLRDVSLEVRPGERLAVVGPSGAGKSTLGKLLAGLDVPREGEVTVGGVAVADLLADGAERHVLLVTQEHHVFTGTLRDNLAMAAPDADDTRMWDALAAVEARWARELPDGLDTSLGADGTRLDAARAQQLALARVLLADPHTLVLDEATAMLDPATARNAERSMAAVLRGRTVIAIAHRLHTAHDADRVAVMEDGRITELGAHDELVAAGGTYAALWRSWQGAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK8</accession>
    <name>A0A7W7WXK8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 14">Catalase</fullName>
            <ecNumber evidence="3 10 14">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">F4559_004849</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>2 H2O2 = 2 H2O + O2</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family. HPII subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="PTHR42821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 14" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="16">
        <location>
            <begin position="80"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4967490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="737" mass="79982" checksum="171B87900595333A" modified="2021-06-02" version="1">MNSRNPVEIVKDAVDKVTERVTPDIPGAPSGDPPSLAEPTGPREPLPPKSDQAAPDTVSPTGAPTGAPTGVNAQQDAFLTTSQGVRLHDTDHSLKAGERGPTLLQDHHLREKIMHFDHERIPERVVHARGAGAHGEFVGYGNAAKICKAGFLREGATTPVFVRFSTVLGSRGSADTVRDTRGFATKFYTDEGTFDLVGNNIPVFFIQDGIKFPDVIHAAKPHPDREIPQAQSAHDTFWDFVSLHTEATHHVLWNMSDRGIPRSYRTMEGFGVHTFRLVNDAGETSLVKFHWKPKLGVHSLVWEEAQLLNGFDPDFHRRDLYDAIESGAHPRWELGLQVFPDTPDQTFEGIDLLDATKIVPEELAPVRPVGLLTLTRNPTNFFAEVEQVAFHTGHLVPGIDVTDDPLLHARLFSYLDTQLTRLGGPNFTQIPINRPHAPVNDMLRDGFHQHAVHAGVAPYKPNSLDGGCPFHADAADKAFIEVPQRIAEATKVRRAAASFDDHFTQPRLFFRSLSPLEQDHVIRAFTFELAKCYEKTIKERELLVLARVDARLCAEVAAGLGLPVPEAQDLRDVPTSPALSQFGHTWPVDGRVVGIVVDADDADGLAGVRAAISALGEAGVTPLIIASRGGDLPHGLAAQRTFATARSVEFDAVLLAAAPSPAPDALPVRAAVDPRVELLVAEAYRHAKVIGAWGGGTALAEAEPGVVVADDPSDVVQDVLTLLAGHRVWARLEPLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP2</accession>
    <name>A0A7W7WXP2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NTP pyrophosphatase (Non-canonical NTP hydrolase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12482" checksum="942BFC9B116134F9" modified="2021-06-02" version="1">MNTLADLKNALRAFAAARDWDRYHTPKNLVMALSGEVGELADLFQWLTPEQAANAMADPELAWNVRDELADVFHYLVRLADKLDVDLVEAAFAKIERNETRFPADSPKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ0</accession>
    <name>A0A7W7WXQ0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="7" type="ORF">F4559_004954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="6">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16029" checksum="559767241097100C" modified="2021-06-02" version="1">MPSVEVLLSRLDPSVPLPSYARPGDAGADLVTTSDVVIDPGERAVVGTGIAIALPEGYAAFVHPRSGLAAKVGLSVVNTPGTIDAGYRGEIRVCLVNHDLRAPVVLARGDRIAQLVVQKVEHAVFREVDGLPDSERGAGGYGSTGGHEVLARTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ8</accession>
    <name>A0A7W7WXZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4344" checksum="FF0345D821D6C2DD" modified="2021-06-02" version="1">MTKLRSLVRCLVTCGLGVLLVLLAVRFGEALWRAVSSVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY76</accession>
    <name>A0A7W7WY76_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="34957" checksum="155A1A4D6D8A493C" modified="2021-06-02" version="1">MTVPTPDRIVDIAIGYMGAKQLFAASRVGLFKALADGPRSAAELAATTGISEKFARILADAMNAKGLLNREEGRYSLAEDAAEYLGGNGATDLAPFLGFLNEISYGHWLQFDNTVDTTTPGDLQMDEGRWAVFMAGVMRYNSLHAEQLSRGFDFSGYRSLLDLGGLSPEFAVGALKANPELTARFVFDPSATQGITDALAANGFTDRATIEPAATDTAAPGGDHDLVMVNHVIHRFDAEQNKVILANARAAAKEGATLLLLDFFLDDDARQRPIDALHAGEYFVIDGTVVYLESEVRDWLTATGWKAREVLSLPGSPRVLVAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB1</accession>
    <name>A0A7W7WYB1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="522" mass="55106" checksum="9C6564A4E5CEA1D1" modified="2021-06-02" version="1">MILDLKLVDAQVLTMDPNTPSARSIGVWQGRIVELDTDLPARRVVGLDGATVLPGFVDPHNHLAWAGRAARTVSVTHCATVAEILDLLRTVPRKAGWLEAAGYDHRTLDRPLTARDLDTVGTKVFVQDLSGHACVVSGDLLVGLPEAVLAQAQRDADGLTGFLAEAGHNAVRALRLPYPLDEVTADIEAGVRECLRQGIVLAAEAGVGGGLIGSTPLEVAAYQRADLPIRVQLMVSATELAVVRAHPSDLVRRALPLGLRTGLGDSRLSIGALKVWTDGGMMARTAALTRPYVGMAGSGMLADTEDDLRDAIVDGHRAGWQLAVHAIGDRAVDFALAALAEAQAVCPRPDARHRIEHAGLTRPDQLVSMAELGVIPVVQPAFLYAYGDDYAAIMGADREDWLYRGRSFLDHGLTLVGSSDRPVADGNPLRGIQFMVDRASSSGRVIGVGEGVSVAEALLSYTTRGAYACHMEGELGSLVSGKLGDFVVLGDDPRTAGRIADVPVLATVVGGRAVFDPHGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU2</accession>
    <name>A0A7W7WYU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CspA family cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_033427733.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7530" checksum="0C1AD867F0048514" modified="2021-06-02" version="1">MAVQGTVKWFNAEKGFGFISPDNGGADVFVHYSEIQTNGYRTLEENQRVEFEIGQGQKGPQAQAVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ51</accession>
    <name>A0A7W7WZ51_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34806" checksum="0ABE4179F928112B" modified="2021-06-02" version="1">MIRLSAITPSGQVQLGNYLGAIRRWAAEGTAEDVYFISDLHAMTSAHNPARLRALTREQLAVLVAAGVAPESVCVQSDLVRELGALTWLLECTCSYGEAARMIQFKEKSEGRASVRLSLLTYPVLMSADILLQGTHEVPVGEDQLQHVELARVLARRFNGTYGEVFVVPRAVVAPTAARVRDLAEPSRKMAKSAPDAAGTVFLLDPPDLVRRKIMRAVTDDRGEVRYDPDGQPGVTNLLEILSACTGKEARELAGSLSDYASLKEATAEAVVAELKPVRERTLALLADPTELDRIRAAGAERARDRSTHRLESALRVSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZH8</accession>
    <name>A0A7W7WZH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="DUF5911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5911" evidence="2">
        <location>
            <begin position="251"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_15" evidence="1">
        <location>
            <begin position="476"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="843" mass="91434" checksum="1F5BD7E0C59938F4" modified="2021-06-02" version="1">MTAEALPAELRRAIVQLARTPRLLVACDYDGTLAPIVANPEDARPSTESVGALRSLAGLHETTAAVISGRALRDLATLSRLPSEVHLVGSHGSEFDVGFVHALDEDARALHRRLEAELEQLVDGHEGVALEVKPASIAVHVRRAEPDVGERVLADVRSGPCTWDGVQVTEGKAVVELAVIQTDKGHALDVLRHRASATAAVFVGDDVTDEKAFARVTGPDLGIKVGDGESLAEFRVGDTTDVATVLAFLLEERRAWLHGDQAVPIERLTMLANERSVALLTPDARLTWLCHPEPDSAAVFADLLGGPAAGHFSIKPEHGSLPLGQRYVPGTMTVETRWSRLLVTDYLDHDLASHRTDLVRRISGSTNAVITFAPRPEFGQVPVRLLRERGGLRVVGTSDPMVLRSPGVDWQISSDGIQETATAIVRPREGASILLELRCGTDDLSEATLGEPERRARAGAYWSDWAATLKLPTVEPDLVLRSALTLKGLVHHDTGAIMAAATTSLPEELGGIRNWDYRYCWLRDAALTAQALVSVGSLGEAEAFLGWVHGVLGTLPGPERLHPLYTLQGTMLGAEAVIDTLPGYAGSRPVRVGNLANQQVQLDVFGPVVDLVVVLAAARGDLTDQDWRMVQAMAEAVARRWHEPDHGIWEERHAPRHHVYSKVMCWVTLDRAVRLAESYGRDIDPAWPVLRDTIANDVLKHGWSDAAQSFTTAYDGDDLDAASLHVGLAGLIDPTDERFQATVTAIEAELRSGSTVYRYRRDDGLPGDEGGFHLCAAWMIESYLLTGRRTEAEELFAQMVDAAGPTGLLPEEYDPIAERSLGNHPQAYSHLGLIRCAQLLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SX75</accession>
    <name>A0A7W7SX75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitinase</fullName>
            <ecNumber evidence="10">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030799445" evidence="6">
        <location>
            <begin position="25"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="8">
        <location>
            <begin position="125"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="241"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="336"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="425"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="853" mass="89687" checksum="9E5D03693422A6E6" modified="2021-06-02" version="1">MRRLATALFALTVLTALAVPAANAATGLTATFSRTGNTGKFVVANTGTTAVSGWSIKFDLPAGVTVSGAQNATTKQNGTKVTLTPAYYISNLPAGRNTDPFSPTFTLSSAVDPTACTINNANCDGSGGPGPAPAPVAAEFELNGNQGKFIVANNTDATLTDWSITFTLPSGVTASNANNGTVAQSGNTVTLNPVHYNKSIGARKTTEPYSPTFQLSSAVEPVTCRINNANCDGTPDVPPTVPANLTSPVKTTKTVSLKWDASKAGSLPVAGYEVYNGTTVAATVTTAAATITGLTPNTAYSFTVKAKDTKGTLSAASTALSVTTNNPADDTQAPTVPANLRSTAKDAGSVTLAWNASTDNKGVANYDVYVGDTVAATVLEPTAVVSGLSPSTEYTFSVKARDLYDNISAASTPVKVTTADIVGGYARVGYFVQWGIYGRQFFVKNLDTSGTAAKLTHLNYAFGNIDPVNLTCLHGVTKGTSPNPQDPNQGDGAGDAEADYSRPFSSAQSVDGVADTGWEPLRGNYNQLKKLKAKHPNLKVLISLGGWTYSKYFSDVAATDASRKKFVSSCIDMYIKGNLPTYNAAGGPGTAAGIFDGFDLDWEWPGAEGHAGNHIGPNDKVNNTLLIEEFRKQLDELTKTSGKRYQITAFTPADRAKIDAGWELGRVAKSMDIFNVQGYDFHGSGSDNSWEPNRTGHQGNLYKDADDPYSFHFSVEDTVNAYLEAGVPPRKITVGLAFYGRGWQGVKDGGKKGEWQSATGAAPGQFQEEAGTRGYSNLIASVPNCTVVHDEPSVATSCFTGDNGQWWTFDDVWSIQKKTAWMKSKGLLGAMIWEMSGDTAGGLLINAVDAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXW9</accession>
    <name>A0A7W7SXW9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA reductase-like NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="22"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="481" mass="51069" checksum="FA95A1770654EA6E" modified="2021-06-02" version="1">MDATTPQPRPCWIAGRPEQGEGSITVTHPFDDTEVATVAVPSPAQVEQAIAAAAAVAKEFRRTPAHVRASALQKVARLLEERVEEIAETITAENGKPLKWAYAEVGRAANTFRFAAEEARRYVGELQRLDTDANGEGRMAIIRRQPRGPVLAVAPFNFPLNLVAHKVAPALAVGTPVIVKPASATPLSALLLGELLAETDLPEGAFSVLPVRGRDMDKLITDPRLPIISFTGSTGVGKAITEAAPGKHVLMELGSNAAAVVLPDWPDLDRAAARIATFGNYQAGQSCIAVQRVVVHRDIADEFIPKLVAAVKALKTGDPHDPEVEVGPLIDEANAKRVEEWVQEAVSLGAVLHTGGQREGATVAPTLLQDVPVQARVWHQEVFGPVLSVSVVDSVQEAFDQVNATDFGLQAGIFTRDVTVAFEAAAELEVGGVIVGDVPSYRADQMPYGGVKGSGTGREGVRSAMDDFTEERTLVLTGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY14</accession>
    <name>A0A7W7SY14_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030660532" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20415" checksum="B419AC7785757247" modified="2021-06-02" version="1">MIKLLSMVAAVGSLAILGATQASAATTDSGPAKATDVKVNGDVSTQACFGPFKIVNPYSNTVVDIDRASLAPGARITTAVRSTSASQLWYRCDSAFGGSVLISAHSGYCIDAALVPGQNLTQESCVGGFDQRFTSVLRFDGYYQTENVGTGLAFDTWQTLAPKYLGQDVRQITSPRQAWYAEYVATPGTLAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY80</accession>
    <name>A0A7W7SY80_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Death-on-curing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="13727" checksum="D8FFF43EF5BFA9D5" modified="2021-06-02" version="1">MVNYLDAGDLLVLATAVTGGDLVVRDLGLLDSAAHRPRATVLGVEAYDTLWLKASALLDSIVRTRPLGEGNWRLGWVAAVTLCDINGWWIDAEEDEALDLVRALGRDQIDVPGLAAHLEAWSLPKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYE3</accession>
    <name>A0A7W7SYE3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="6775" checksum="49A7A01D891F42C1" modified="2021-06-02" version="1">MAEVETNRGVDVVGLVFGVSALVAAAYMLSDGKSWPAFLDVRWLLAGGAMVIGIGLLAGAARRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYE5</accession>
    <name>A0A7W7SYE5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (TIGR01319 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01319">
        <property type="entry name" value="glmL_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="414" mass="43168" checksum="3FDDD100AABE35F2" modified="2021-06-02" version="1">MTVLCLDVGSTWTKGTLVSHDGELLGTAQHPTTTPEVMHGISEVLSGLPAAERVVACSSAGGGLRLAVVGHERLVSAEAGYRVALSAGARVVHVSSGKLRGVKELRATRPDLVLLVGGTDGGDEDVLLHNARRLAVARIACPVVLAGNADARAEAESLLSGRIVVSTGNVLPDVGVLDPEPARRAIRDLFLRHVIGGKGLSRGNRFRRMVRAVTPDAVLSGVSHLAALQTDGAVLVVDVGGATTDVYSAVRASDGAERTVALPPDRRTVEGDLGLRRSAPGVVEAALADRLLTPEEAEFLAREAEFRAAHPSWLPEDPEVDRRLAALAIVVAVRRHLAYVGSLGPHGARLVVLSGGVFRHAPSTEVFEDALREDPALRPVVRAATVVVDRHHVLAPAGLLAGPVAAGLLGSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYF6</accession>
    <name>A0A7W7SYF6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="236"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="303"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="572" mass="61839" checksum="BF72614791913961" modified="2021-06-02" version="1">MTPRLLEPAARQARRIAESGRRRAARFGELWRRSLQVRVVVSTLALSSAVVFVLGMVLQVQITGRLLDTKITAAIRQAEVSAAAIQPDLSGLNPGPDNVRSRFTSALNKISSAAGTDTTISGAGAFEPVLYDPVGRGSDGQPIAVGAWRDVPDGLVRMLEAGGAGYQITTVEHDGVPTTLLVVGKPVNSSARPMHLYLLFPLAGERATAEVVQSTLVVGGLVLLGLLAVIANLVTRQVVRPVRQAAEIAERFADGSLDERMPVIGEDDVARLAESYNEMAASIQRQFHQLEEFGQLQRRFTSDVSHELRTPLTTVRMAADVLHASREQFPAGLARSTELLVDELDRFESLLGDLLEISRLDAGVEELAAELVDVRVLARRAHDAVRAIADSSGTKLVLDMPDHEVTAEVDARRVERILRNLLANAIDHGEGLPVGLTLRADGDALAVAVRDHGVGLRPGEAELVFNRFWRADPSRNRRTGGTGLGLSISLEDARLHGGWLEAWGERGHGAVFRLTLPVRRGHEIVESPLPLEPPDLPPPVAVPEPEPVEEVELTEEEITWQPAQPVTADPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG1</accession>
    <name>A0A7W7SYG1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="524" mass="54239" checksum="B417732A11251F46" modified="2021-06-02" version="1">MHDGTGRIVVQNLTKQFGPVAAVQNLSFTVEPGTVTGFLGPNGAGKTTTLRMLLGLVTPTSGVGLINGRPFHQLGNPARVVGAVLEAQGFHPRRTARNHLRVYAAAIGVPDQQADRVLELVGLGAAADRRAGGFSLGMKQRLALATALLGDPQILVLDEPANGLDPEGIAWLRQFLQSYARSGRTVLISSHLLAEVEQTVDQVVIVSRGQTMFYGPLENLRAGREGRVLVQPSDIPALVKALQEAGITNLEQAPDGRIAVVGGDAKRIADVALQAGVSIYGIQEEKVDLEQLFFQLTNGQYTGQGPYGQQPPPGPHYAAPAGYAPQGQVPPGYAPPPGYAQPGFPAPDQSGYAPPPGGYAPPQPGFPPPDQSGYARQTGYAPPPLPSGNAQPGFPAPDQSGYGAPGPSGYAPTAPDQSGYTRPVTPEQPTQAVEQSGYTRPVTPEQPGFPSSDQAGHPTQVVDRSGAVTPDQSGFPTAEQAGDRPGDPASDRTAPDPVVPPGEAPPPDGQPGGQRNQGGLGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP0</accession>
    <name>A0A7W7SYP0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="26023" checksum="2CE025A44098E880" modified="2021-06-02" version="1">MRLRLTAHPVVGHGTLHRVLVPRFELRNLWVRSPAYGYGMLIGSRADLLRLGALARLAAISPHSAVHVPLRHVPLDDAMLRASFRDGPQCDLLFVRQETGMPASAWPEIRTGMRRRRSSARPLTARLSDEWDDSVRREWHPRPRWSEHADTMIFTGDAGGLHALARCVTEAGDLLADDRSIHRFGLSALLGLTGLFGGDDHEFDVYGRDPIFHKSRWARLRNAQECPSASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ4</accession>
    <name>A0A7W7SYQ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="45093" checksum="1390EDA2CA75FF8F" modified="2021-06-02" version="1">MSGVEACRAVEAVWRIEAARVIAGLARQFGDVGLAEEMAQEALVTALEQWPTTGIPDNPAAWLTTTAKRRAIDHLRRRRNYERKLAEIAEDEQHEPDAAALVGEIDDDLLRLVFTACHPVLPLDAQVALTLRLLGGLTTDEIARAYLTREATIAQRIVRAKKSLAKAQVPFEVPDENERPARLAAVLGVIYLIFNEGYSATAGDDWMRPELCADAVRLARVLATLVPKEPEVHGLVALLELQYSRFKARVDAQGEPVLLLDQDRTRWDRLLITRGLTVLEQAGPTGPYGIQAHIAACHARAARPEDTDWFRIAGLYEALALIAPSPVVELNHAVAIGMAFGPATGLELVDEIVAAGTLVDYHLLPSVRGDLLVKLDRPAEAEAEFTRAASLTRNERERALLLARAAACRPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR4</accession>
    <name>A0A7W7SYR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloramphenicol-sensitive protein RarD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EamA transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004626">
        <property type="entry name" value="RarD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF114">
        <property type="entry name" value="PTHR22911:SF114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00688">
        <property type="entry name" value="rarD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32563" checksum="51661AA1E46E5940" modified="2021-06-02" version="1">MPPLTSSPAVSSTVDQTKRGIAYSAGAYVLWGVVPAFWPLLVPAAPTEILAHRIVWSLVVMAAITTAVRGWRVLRALPAKGWLLVTAASALIAVNWGVYIHAVNTGHVVESALGYFINPLVSVLLGVLVLRERLRLPQYAAIAVAVAAVVVLAVDYGRLPWISLVLAGSFGVYGLIKKTIELDARSSLMAESIVLAPIALGYLVVSPGGTFTGHGFGHAALLASAGVVTAIPLLLFGAGAKLVPLVTMGMLQYLAPILQFSWGVFVMHEPMPPSRWFGFALVWVALAVFTFDAVRRGRRRIVAPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ25</accession>
    <name>A0A7W7SZ25_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">F4559_000957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="24472" checksum="FFC62B5F451266C1" modified="2021-06-02" version="1">MRLVIARCQVDYVGRLTAHLPMAQRLLLVKADGSVSIHSDDRAYKPLNWMSPPCWLIEEPDLWVVQNKAGEKLIISLAEVLHDSKHELGPEPGLVKDGVEADLQKLLAEHVTTLGEGWTLVRREFPTAIGPVDLMCRDSSGSSVAVEIKRRGEIDGVEQLTRYLELLNRDPLLAPVSGVFAAQQIRPQARTLAEDRGIRCVVLDYDALRGIESDEFRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB7</accession>
    <name>A0A7W7SZB7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="4">GMPMT</shortName>
            <ecNumber evidence="4">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glgE</name>
        <name evidence="6" type="ORF">F4559_001018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="199"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="4">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="659" mass="74146" checksum="395AC40A0F962020" modified="2021-06-02" version="1">MSGRLGIDDVSPTVSGGRYPAKAVAGEHVPVRATVWREGHDAVAATVTWRGPGDRVARQTRMVPEGIGLDRWAATIVPDAQGAWTFRVDAWSDPWATWLHTVEVKIAAGQGEGELANDLETGALLLDRVARRPDRRREKPTLVRAAQALRDEELPLVERVASALGTEVRRVMYEHPVRELVTKGRQLRLWVDRERAAFGSWYEFFPRSTGGLDEAGVPVHGTFATATRELDRIAAMEFDVAYLPPIHPIGRVNRKGPNNSLVATEDDPGSPWAIGADEGGHDAIHPELGTLEDFRAFVARAHELGIEVALDLALQAAPDHPWVLKNPEFFTTRPDGTIAYAENPPKKYQDIYPVNFDNDPQGVYNEVLRVVLHWVEHGVRIFRVDNPHTKPPDFWAWLIDTVKKTHPDVLFLSEAFTRPARLYGLAKLGFTQSYTYFTWRTSKEELTRFGTELVEHWDEARPNLFVNTPDILHESLQHGGPGMFALRAALAATLSPTWGVYSGYELFEHEAVRPGSEEYLNSEKYQLRPRDYAAALAQDRSLEPWLRRLNRIRRAHPALRQMRTLRFHHVGNDALIAYSKRDPATGDTVVVVVNLDPQQAQEGILDLDLPVLGVDWHDRLIAHDEVSGQTWDWGAANYVRLEPWRSAAHVVAVQRRFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZH5</accession>
    <name>A0A7W7SZH5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="10259" checksum="FD1257B6FBBA1B21" modified="2021-06-02" version="1">MAGLQPTSGNDVNTQLGVIARNVFAALADVKQAKDWLDTMPDNTLTSPPFNMTSGDVAVLKSAFADLAKLAAVFEGTQPHSPAADLRGFARQTIGINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM8</accession>
    <name>A0A7W7SZM8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate guanylyltransferase</fullName>
            <shortName evidence="1">PEP guanylyltransferase</shortName>
            <ecNumber evidence="1">2.7.7.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbiD</name>
        <name evidence="3" type="ORF">F4559_001237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine</text>
            <dbReference type="Rhea" id="RHEA:30519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="EC" id="2.7.7.105"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CofC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.105" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="PTHR40392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="20703" checksum="385A154A57B575E4" modified="2021-06-02" version="1">MRTDVDLVVPVKSLSRAKSRLVGVTDDRPALALAFALDTIAAAVRVVRSVTAITDDPAVAAALADLGVGSIPGPEGLNEALTFGATLLRSRDPHSVVGALQADLPALRPTELAAALTAAHDARAFCPDRQGTGTTLLLSAPGKPLNPSFGPGSARAHESSGAHRLTGPWPSLRHDVDTADDLDVTATLGLGERTTAALTPVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN4</accession>
    <name>A0A7W7SZN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6871" checksum="3B475452D305DBA2" modified="2021-06-02" version="1">MWKGPIEFSVTPEAGGDVRLRISDAGGQWATISLTNAEASAIGGGLTSVAEQSARQHAESVRDTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX5</accession>
    <name>A0A7W7SZX5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
            <ecNumber evidence="4">2.3.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="39"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="40376" checksum="D81D8061270BBA70" modified="2021-06-02" version="1">MSVSTGESVFDWIDTRAGARAKAGLTRTVRPRAAHSTDLDLASNDYLGLTRDKRVTGAAAAAALRWGAGSTGSRLVTGSTELHTELEYELANFCGAQSALVFSSGYAANLGALMALSGPGTAIVADQHIHASLIDGTRLSKADVVVAGHCEVPRITHALATRGKRRALVVTDSVFSVDGDLAPLADLVATCREHEAALVVDDAHGLGVLGDGGRGAVHAAGLAKAPDVVTTVTLSKSLGAQGGAVLGPSRVIRHLIDTARTFIFDTGLAPASAAAALAALKVLREEPGLPERALTVAQDLAFRLRENGLPASTPSAAVVSVRAPSAESALEWSRACRAQGVLVGCFRPPSVPDQVSRLRLTARADLTEADVERAVRVITETGASAGAVSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K7</accession>
    <name>A0A7W7T0K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-methyladenine DNA glycosylase AlkD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="25074" checksum="875E0CBA16D93F9D" modified="2021-06-02" version="1">MEALTAAVRQALATAASPERAPAMQRYMKSEMPFLGVPKPERTRVLRPVFAAHPLASAEEWAAAVLDLWRTADHREERYAATALLDRYPKWRSPGLLTVLEELIVDGAWWDHVDEVASRHVGPLLLGWPDEIAPIMRAWSRDADRWRRRTSVICQLGAKTATDTDLLAECVEANAADKDFFLRKGIGWALRQYARTDPGWVRVFVDSHTLSPLSVREALKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T8</accession>
    <name>A0A7W7T0T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent protease with MMP-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16294" checksum="CEC60AB952F45137" modified="2021-06-02" version="1">MVMARGSRRPGAPRRRRDRHGRGLRGPLYPATLPAARSRAERFDALVLEALEPIEARWRAELTQLDVAVDDVPDVASTDDGDVVEDGNVPLARLLPAGSDRRARIVLYRRPLEARAKDGADLSDLVHDVLVEQVANYLGLDPDVIDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W3</accession>
    <name>A0A7W7T0W3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="1">PPIase</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031611204" description="Peptidyl-prolyl cis-trans isomerase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="68"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="25336" checksum="F1E766038FF66E26" modified="2021-06-02" version="1">MKILLALSFVAGTLLVGTAQAQAVGEPDVTRGPCAYTKTPDEPPARPVGLPRDPRHTPDRGKVEVVLQTNHGPIPLKLDRAQAPCTVQSFLHLLDRKFYDRTFCHRITAYATLKVLQCGDPSGTGEGGPGYKYKDELPKNLPPAPNDPTGERRIYPRGTLAMANAGPDTNGSQFFLVTADSTLRPNYTVFGTIGESGLRTLDKIAAAGIKPTPENPAPVDGAPAKQVDIRKAKRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0X9</accession>
    <name>A0A7W7T0X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="691" mass="76185" checksum="1FA8ECD26B07956A" modified="2021-06-02" version="1">MFGVPGPGTLMAHHVWLRACTPTDRAHVREALDLPPPLLVVDAHRGLRGPYTGAGALLRAVAPEAFRHAPDLAVRHNTELATAAPELAVHVPTAWSTLEWTVSDERRTRFYSRLHTRGIADGITAFLRTHLDQADGPRTLVVDNVHHADQTDREFLAVLLRRMDPARLTVVVGTDHDDLDDPPGPLSVSLPRVLPEFARVVDGPSVARHHDDRTYVDSDGTTDNPDAIAEYRALPKEERARLHDERCDALYALGEQSLALGAIPFHAERGTRRATLGVNALKHALGHCRKVGLYHAAADLALRGRALVERTREPGLWWHFTEGAAAALATSGRADEAALVYDEARSVTENPEQQLRLAYGTAMLHVRHLPAHRRDPAQARGWMDLAIALADRLTDPREAAFHGVFARNGLALIEVRDGHTDEALRLVDAGLAALDQEHALLHSVLRLNRGLVLAAAGRFEDALDEHFANTVLDPGFPEHHFHVGTLLRRLGRDREAIEAFERVLTLSPPFPEVHYNLADAWSELGDARRALAEFDQVLDLDPEHLRAYVNRAALRFEVGDTHGAREDVEAGLLLAPEDPHLLCVKAKLLAEDGDLRAAAAVLSTAVRHDPSFASAWALRGQLRFETGDFTGALADLDRAVALDDSPEVRFNRAVVFEKVGRYRDAAEDYRAVVDTYEDARSRLDFCLRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T164</accession>
    <name>A0A7W7T164_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="39704" checksum="6228BD93F6ED354D" modified="2021-06-02" version="1">MRSDSGRRFDRRDERSRDRAARFQERAASTDQTETGAEVEPDDVDPVIAKQVAEATGEVPESVGRAGDDVAGEDDLEDDLEDDEDEADSDDDESVVGERDDDVEDDEDETDEDGDRRSADVGAESPAEGGRDGRRDGDGGRTRAPELPEEADISLLDPEIRQELRGLPKGLADIVGRHLAAAGLLIDGEPEVALEHARYARLKAARVGVVREAAGLTAYYAGEWAEALSELRAARRMTHGSGNLAIMADCERALGRPERAIELARDAQGLKLDPEEAVELRIVVAGARRDMGQHDAAVVALQGPDLDEKRRDPWSARLFYAYADNLEAAGRTEEAVRWFLNAAQADDDNETDAAERAFDLSPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1E7</accession>
    <name>A0A7W7T1E7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="342" mass="34513" checksum="2A5D7F1E584A4CA5" modified="2021-06-02" version="1">MKTLRAATLSVRVHERTAFVATALALLVVGVGLLTLVTGDFPLTVGEVVDTFLGRGDGASEFVVFTLRLPRLVTGLLVGAALALSGAVLQSLSRNPLAGPDIIGFTQGSATGAIAVIVLAQGGMTAVAAGSAVTGVLTSIVVYLLALKRGVHGFRLVLIGIGVNAMMLAVNSYLITRATLESALAAQSWLVGGLNNRGWDHAATVAVVLVVLVPLALVLQRRLALLEMGDTTAIGLGVDAGRTRLALLAISVGLAAVATAAAGPIAFVALAAPQVARRLTACPGPGLASSALTGALLLAAGDFAVQRLFPTAQLPVGIATGAVGGLYLVWLLAGEWRKGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1N9</accession>
    <name>A0A7W7T1N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium chelatase subunit I</fullName>
            <ecNumber evidence="2">6.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="50169" checksum="C003B145AC7D01E3" modified="2021-06-02" version="1">MTSDLPTTAGALRAAGYAPRSVKAELRENLLAALREKRDPWPGIVGFDRTVLPQLERAVLAGHDVVLLGERGQGKTRLARTLVGLLDEWTPVIAGAELNEHPLDPITPESVRRAGELGDDLPVAWKHRSERFTEKLATPDTSVGDLVGDIDPVKVAQGRSLGDPETVHYGLLPRSHRGVFTVNELPDLAERIQVSLLNVMEERDIQIRGYTLRLPLDVLLIATANPEDYTNRGRIITPLKDRFGAEIRTHYPLEVEAEVALVRQEADLVAEVGDHLLEAIARFVRHLRESSAVDQRSGVSARFAVAAAETVAAAALRRSALIGESPAVARPVDLESVPDVLRGKLEFEAGEEGREREVLTHLLRRSVADTARSRFAGLDLRPLAALVSDGHPVATGERVHGGDLLAALPELPVLHEIAARLGVGPRDSAGRIASVVELALESLYLTRQLAKDQDDERSVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P6</accession>
    <name>A0A7W7T1P6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="24023" checksum="BD9C2BF795B7CCC6" modified="2021-06-02" version="1">MVIGTGTVPAQSIKDVETRVWRLCHSLAARLQFHGWHHVSFVRDKAVHFARRNGADVALVEVAALVHDVNYMVRRNSLPVDGRALRLSILADAGVADLVAHRVDRVVEEAEMRTRHRDISLEAQALSDADTLFKALPVTPVVLAPKYLAENGITLRELAHKIVGEQRGKHDEGYYFYDPEAAATYARWATANLELWQCIVESLEDPEVAELLSAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T243</accession>
    <name>A0A7W7T243_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="15" type="ORF">F4559_001304</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="14">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4963945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="27678" checksum="F0309328985C459F" modified="2021-06-02" version="1">MIRKPPRVQVRQNAGIWAFQAALDRRGLGPVAGVDEAGRGACAGPLVVASCVLDCRDAARFEGLTDSKLLTANARDRMYDLVLDRAVDYAVIVIPSSEVDQLGVHVANIEGMRRAVARLSAHPGYVLTDGFPVPGLTAPNVPVVKGDRVVASVAAASVLAKVTRDRIMTDLHGELPVYGFAVHKGYSTADHTAALLEHGPSAQHRWSYANVATAAARHGLVAPHRLARGVVTAGVVQNGTPPPDGGGGHATRRGADSMNTRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T244</accession>
    <name>A0A7W7T244_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="575" mass="58982" checksum="0425F1ADE869B523" modified="2021-06-02" version="1">MTVPPVAPAVVADVLDALPPRLRKRVDASLDKVASWTVATESGAARAELDADTVLTWTLHDGVLTSADDLVCGCLLAPKCLHRGIAVAAADVSDAVVTADEPVEAVVAEPEVRVEVREDERAAAGELWDACSTVLRSGASGSGVVVRAELLRAVHVARVAGLHRAAATGLRVASALNAARTGASTFDRRVLTADLVDLMLLCHDLRTGTGDTAVLRGTARREYTPIGSLRLYGLCTEAVVASSGYAGVVTHLVDDSGVLWTVPSIMPGGPELVVAAASGPVAVGESGLSQRALGRGGLLLSGGTGSPDRRLGAGKAVRAVSASGADWTSPPLAGLWETPLADQVARAFAAAGQPESHRPSGDSLLFLEGTVLGAAGPAVRLAVGEGQLDLVGAGERTRANLKVLAGATGRVLRFVARILPERPGTAVALAVAGDLVLPADLRHHVDLGLDVLQRSHAPGDGDVELPEPVAVGERVPAALRPLDNVLHRVTLGGRAVAAVASTGRDVAVLAGHGLTGTAAVLADLTTTSRDRQRDAFGRVVRDAGDSFPMAWLRAGVHVREFGQAVAQRAWLAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C7</accession>
    <name>A0A7W7T2C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acetyltransferase YhbS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="41904" checksum="1FBD86C770D62E77" modified="2021-06-02" version="1">MTDGLVLRTARPDDLDAISALLTDRGAAADAVDHRLVVEDPEVGWDACAVVVDGDRVVSTATLFDETLVLDGVPIPAGQVELVATDRAYEGRGLVRRLMDWAHDRSARRGHLAQLMLGIPYFYRQFGYTYALPIAAVRPVRDKPDANGHTIRVATPADIPAAARLQDAAQAGADLSMPHSPALRRWLLDRDGSTVWVVERAGAVVATGRTTPPEEGNRLAEVAADDEAAAHALLALTGATEVSERPGTVAGDALEPLLHPGPEEIRGYYVRVPDTFALFAHLKPVFDRRLAGLGRADGEALISFFREHLRLPFREGALGTPLKGGRMQGPYDLGGAGVAPDQVASLLFGPHGIRGLARIFPDVYPGPDRELMYALFPPVRADILTFYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D7</accession>
    <name>A0A7W7T2D7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="486" mass="51196" checksum="9EEFE8D0554334AE" modified="2021-06-02" version="1">MWDLRSRRYLAVKLLRAADAAALLRFVREQSLRVDHPHVVAPSGWAAEEDEVLLTMDLVGGGDVERLLGDFGKLPLTFAAALVDQLLDALTVVHGHGIVHRDIKPANLLLEPTGTGRPFLRLADFGIAAVIGEPRLTDDRIAVGTRGYIAPECVLGALPDVRQDLYAVGVLTCRLLTGQPPSTEAFDDLPQSLRPLVSALCAESPDDRPASASAARKDWLAAMDLAGSEPLDPADPHPVEVFEHLDPLPPGYGPDGPVTVAASDEMAADAQPSRARPTRRRVAVTAGCLAVAAGIVTPITMSTMDVSGKAVAPTSGPVATRDGSPPFVAAPPGTNLLPDPGAEAYPPNWTAFGSGVVGQDDIRRTGSKSLRVTTTATGANSAGATTRSDSSRTAEGTTYRAECWVRSSGRIGVFLQVQEYTPDWQRVGEPVPSAKTALDDPGRWFPVSVTYTATRGGNLLPITVFSNNLRAGGDALLVDDCSLTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U6</accession>
    <name>A0A7W7T2U6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23202" checksum="F1E645A6F309D17A" modified="2021-06-02" version="1">MNDSAGGYTAAEALALVQGVLARTHMGAGSPGDLVAALTVLRELREELAGWEPELITAAREQKVSWAALAPALGVTSRQAAERRYLRLRPSDTGEQTGEERVRAQRDKRAGDRAVATWARDNAAVLRQLAGQVSSVQGLSRRAQRHVDLVGQALAEDDPARLLPPLADTHTHLKATHASLAAQVRSLTDQATQIRHTSDMTRSDSAPAAEQRTGNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T314</accession>
    <name>A0A7W7T314_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4185" checksum="B4CD2A12B2FB636E" modified="2021-06-02" version="1">MFHTPVDGRHLPKIDGDPAIITSKGGGIGSETVPPPTMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T320</accession>
    <name>A0A7W7T320_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="153"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="32757" checksum="08F394BB2E69B596" modified="2021-06-02" version="1">MSTTDAFDLVLLAVDDAESAHAARLARELTGEVRRVSVLTAPAVMVEPAPGPVVVHAFSAAGAGRPVPAGPGAVTVVHDHRGDDGPPCPTADHVVVGSHAEATAVVAAGFARGSVSIVARPVDERYWAADGPAADRGDAIRLVATTGLRPGDGTDTAVAALARVPDVELVVTGPVDSPAPAHRAELGRLLDGAAALGVAGRVRFVSGPTPEVIRSADVVLHLPWSAAPVDPVLHAMACGVPVIAGATGGLPETVVDDLTGVLVPPRDPRATARAIRRLCQDKTRLAAFSVAAVDRVAQRHSWTRVAGELLRVYREAAGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T331</accession>
    <name>A0A7W7T331_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cellobiose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="45353" checksum="1B766244221CF429" modified="2021-06-02" version="1">MRACRPLWLLAAVLLVVTGCSGGDGDLRLTVATFGRFGYEPLFEEYERAHPGIEVVGRVADFEAHHKGLITALAAGAGAADVVAVEEQYLPRLRRSADKFVDLSRFGAQDLRERWTPWKWRQGVSEDGKVVLGLGTDMGGLALCYRRDLFERAGLPTDRTAVAALWPTWEDFAAVADRFADRVPDSRFVDSAGTVYTAVLDQSEESYFAKADDSFIADTNPAVRRAFDIAGALAAKGRTAKVSAFTQPWNVAINQGGFATVTCPAWMLSQIEDAGGPANAGRWDVTAIPGGGGNWGGSYLTVPAQGAHQREAYELAKWLTAPEQQKRLFLSDGILPSQPEVYRDPAVLGHRDEYFGDAPVGELFAASSDTVRPHHRGVREADVRPVFGRALGRIEDGSQSVDEAWRQSVGEARDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C6</accession>
    <name>A0A7W7T3C6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26901" checksum="753E40C3B387B3F2" modified="2021-06-02" version="1">MPTSRRDLAESFGVDPARYDRTRAAYPREVIARVVSAAPGPALVDVGCGTGIAARQFLAAGRTVLGVEPDTRMADFARRTGVDVEVATFEAWEPAGRLFDAVVSGTAWHWVDPVAGAAKAARVLRPGGVLAPFGHVYELPAPTAHALADAYRRVAPDSPIGFGDRSILDAYQGLYTRAADGVRAAGGFDEPVVWRHDWERTYSRAELLDLIPTSGGLTGLPPGHLAEVLDAVAATVGESVTLPYATWGLTAIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3H7</accession>
    <name>A0A7W7T3H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="36" mass="4059" checksum="26470043AB23E5FB" modified="2021-06-02" version="1">MLRDDGVWRVVELGDGQVGDRPRTMDAEAFIDMPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M2</accession>
    <name>A0A7W7T3M2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen operon protein</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="105"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="680" mass="76511" checksum="42303EAB6B1B9C2E" modified="2021-06-02" version="1">MAEYVELCLFDDTGRETRVRLPEVDGFVHHGYLLGVGPGQRYGYRVHGPYDPKRGLRCNPNKLLIDPYAKAITGTVDWDESLFGYPFGDPDGRNDADSAGHVPLSLVVNPFFDWANDRPPKTPYNESVVYETHVRGLTMLHPEVPQRLRGTYAGLAHPAVIDHFKALGVTAVELMPVHQFVTDHGLAEKGLRNYWGYNTIGFFAPHEGYAALPETGNQVQEFKGMVRALHEADIEVILDVVYNHTAEGNHLGPTLSMRGIDNQAYYRLVDDDQKHYMDYTGTGNSLNVRSPHTLQLIMDSLRYWVTEMRVDGFRFDLAATLAREFYDVDRLSTFFDLVQQDPVVSQVKLIAEPWDVGPGGYQVGNFPPLWTEWNGKYRDTVRDFWRGEPATLGEFASRFTGSSDLYQDDGRRPYASINFVTAHDGFTLTDLVSYNEKHNQANGEDGRDGADDNRSWNCGVEGPTDDPEVNELRARQRRNLLATLMLSQGVPMLLHGDELGRTQDGNNNAYCQDTELSWVDWTLAEKNRDLVEFTGALGAFRRAHPVLRRRRFFQGKPIRKGDELRDIAWFTPSGAEMTERTWEDDFGRCVVVFLNGEGIPDLDQRGMRVLDDSFLVAFNAHHEDIEATLPNADYGPEWTVVVDTATGVVADPRTGETVSAGGRVTLSARSLVVLQRNGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T428</accession>
    <name>A0A7W7T428_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29674" checksum="4CEFC7705540FEF4" modified="2021-06-02" version="1">MTSTHQDRIAITDLVNRHGHLVDAGDLDELDALFTPDVVYDVTALGFGSLRGTAALREAALALGTANPVGHHVTNIVITDLDENSARVRSKGIGITTDGKADSVVYDDTVVRHSDGWKISHRRVIARREPLSGRTTGPVEILERWRRAVVKQSTKDLADLYAVDAVHEFPFTRPEFPSRLTGRGEILAWTTTIWNSTPLRYARYRTLALHHTGDPGTIVVEQEAVGTHPATGDFVLPNLIVLTTRHGWITHLRDYVDIEAAGAALGSAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4A3</accession>
    <name>A0A7W7T4A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein/short-subunit dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="902"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2591"/>
            <end position="2666"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4254"/>
            <end position="4332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3109"/>
            <end position="3132"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="937"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2626"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="4292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="4406" mass="456221" checksum="3647C0BD643D5351" modified="2021-06-02" version="1">[encoded data, 4406 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4F7</accession>
    <name>A0A7W7T4F7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031272284" evidence="1">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15641" checksum="A50C86ABA24F8CB5" modified="2021-06-02" version="1">MPFTRHLAVLAAAVGTLVALGGPAMAAGDQDGTEGTRVTGVHILSAADATLLPDVHSPEQLAASCPADHFCGYGDAEGYGKAWKGCGRADNPWRGTGWWINNLPGTRDRVAMFDRRTGKKSYVTPHSPSRDLTGDWTNVKFMQLCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S4</accession>
    <name>A0A7W7T4S4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031557502" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="163"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="516" mass="56163" checksum="5B31FABF9B6A4924" modified="2021-06-02" version="1">MKVRHRVASVLVALVVVGGAPVGSASATPLPRLVPEPVSVQVKSGGYTLSASTKIHTSPGARGVGEYLAGILRPSTGYRLPVTSAPHGGISLVLGGVPKAVGDQGYQLTVTRSGVTVRAASTTGLFSGVQTLRQLLPPAVEKRDRQHVRWTVPGVTITDHPRFAHRGAMLDVARHFHPVAAVKRYVDQLALYKINYLHLHLTDDQGWRFQVDSWPRLTTHGGSTQVGGGPGGYYTKAQYREIVAYAAARKITVIPEVDLPGHTNAALSSYAELNCDGVAPPLRTDIEVGYSSLCVSKDVTYRFVEDVIRELAASTPGEYLHIGGDEAQATTDEDYQTFMSKVLPLVGKYGKKVLGWHEFVKTTTDTSAVPQYWGRSTSNAVVQDAAARGHRVLMSPANKTYLDMKYDPTTPIGLKWAGYIEVKDAYEWNPGAHLTGVPESSVLGVEAPLWTETIETSAHIDYMAFPRLAAIAELAWSPWSTHDWEGFRTRLAAQGERWTALGIDFYRSPQIAWPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T566</accession>
    <name>A0A7W7T566_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="38" mass="4139" checksum="5F0D12130A1A243B" modified="2021-06-02" version="1">MITTPGVAPFRKEALKRELADVDAVPHKAGTTTTEETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E5</accession>
    <name>A0A7W7T5E5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Beta-lactamase</fullName>
            <ecNumber evidence="2 4">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="2 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023650">
        <property type="entry name" value="Beta-lactam_class-A_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00118">
        <property type="entry name" value="BLACTAMASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00146">
        <property type="entry name" value="BETA_LACTAMASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030880577" description="Beta-lactamase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="7">
        <location>
            <begin position="56"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="30461" checksum="2DE6B6371948708F" modified="2021-06-02" version="1">MIVPRVVALLVLLSACSTPDDRVTATASAPPPDPAFVELERRFDAQVGVYAVDTGSNREVSYRADQRFAFASTFKALAAGLVLKAHEGGLDRVFRYSPAEIVDHSPVASGKTGLTVLETCDAAVRYSDNTAGNLLLRDLGGPKGFTAALRDLGDETTRSNRTEPTLNDTSPGDFRDTSTPRALATTLRTLLTTDRLPDTPKSILLDLLHRNTTGDKTIRAGTPEGWTVGDKTGTAAYGTRTDIAVVTPPGRAPILLAVLTTHTNKDASSDDALVAEAIRMALEHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F6</accession>
    <name>A0A7W7T5F6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="40161" checksum="6B7AF0FF57693184" modified="2021-06-02" version="1">MPAPVDHLGYDKHDPAGRGTGNSRNGIRSKTVLTDVGPVEIDVPRDRNAEFEPRIVAKRQKRLTGVDEMVISLSAKGLTTGEISAHLAEVCGAEVSRQTISTITDKVVEWQDRPLDVVYPVIFIDAVHVKIRGGQVANRPVYMAMAVTVEGHRDFLGLWAGDGGQGAKYWLHVLTELRNRGVADVLMVVCDGLTGLPDAVTTVWPRTVVQTCVVHLLRNSFRYAARQHWDAVAKALKPVCTAPTEAAARERFAEFVDAWGARYPAIVRLWDNAWAEFVPFLAFDTEIRRIVCSTNAIESVNARIRRAVKARGHFPNEQAALKCVYMAVVSLDPTRTGRKRWTMRWKPALNPLGQTYVRHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H8</accession>
    <name>A0A7W7T5H8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22251" checksum="0B52BFD4C00836F8" modified="2021-06-02" version="1">MTDPLANVQRLVDEWERDAEEKSARYESVRHEVERICITASAAGGAVSVTVGPNGIPSAVTMTDGVSRVRPAQIAAAVMEAMAKARAGYPAPHSGDERLCCAVGARVDAGPVAAARPVVCVPPEQARRGPATTGTEEVVMRWYCGDGYGWGMLPVIGLSVLLVIVIAVVAVVLVRSQRGGSAARIVDERLARGEIDTEEHARLRSALRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I1</accession>
    <name>A0A7W7T5I1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="3 9">2.7.1.180</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ApbE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="3 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="26159" checksum="112037F8E113777D" modified="2021-06-02" version="1">MTGRYVAQVMGMPVSLALRGRHVADGVARAAWDAVVAELRAVDRVFSRFRTDSFLSRLGRGEIGVADCPPEVAEVLELGARAERESYGAFSVRRRVDGESVLDTDGVVKGWAAERAARWLELLPDTDFCLSAGGDLVCRAESVPWRVGVEDPFGPGRVVAVVPVVRGGVATSGTAHRGAHLVDARTGLPARGIASVTVVADSLTWADVDATAAWALGGDAVEWLASRGRGGLVVWADGSIAVVSSGGVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T9</accession>
    <name>A0A7W7T5T9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="18090" checksum="BE3269BC4287350D" modified="2021-06-02" version="1">MTTIEKSADVEVPVTTAYNQWTQFETFPSFMEGVERITQVDDKRTHWVTKIGGVAREFDAEITEQHADERVAWHTVDGPRQAGVVTFHRIDDRTTRVHLQMEYAPETLTEKAGAALGIVEHRVKGDLKRFKEFIENRPNETGSWRGDVNRPPQAGDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V4</accession>
    <name>A0A7W7T5V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="483" mass="51866" checksum="3EC21238BD275FBD" modified="2021-06-02" version="1">MGERSTTDRDRAGKKARSAKDIVLEPDVTKPRQRADGATLVIVYLLALLIIPARLVLSFVPMTLPPALVIALLLGVVWLATQMVDTLNMGKGRNAVRTALALILASQLATYGVATRRFLPMDELTVADSSIIRIVATISLAIFITDAIRTRERLDKVMKVVLGSAAVIAFVGLVQFGAGIDLASYVSIPGLRAQENGYAVMESRSIFRRPTGTTNHPIEYGLICAMAVPLGAHYVFKAKDEGTPYIRWLICLALAGLGAMTALSRTAILGMVTAAVVMIVTLPKKRRITALLVGGGFFLGASLVVPGLFGTLRGMFSNISDDPSVKARTADYEQASEQIDLNPWLGRGFGTFLPTKYTILDNQFLLTLIENGYLGMFALILMFLTAAYAAIRVRMISTDEHLRGLASCLLGGVLAGGIAAVTFDLLGFGVATGTVFVMVGLTGATLRIAREEAGPARKRPTPQLFRKARKPDQRTDKPLSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V8</accession>
    <name>A0A7W7T5V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="39509" checksum="C6BA2B877FD82337" modified="2021-06-02" version="1">MIPITRLYVGQEEADAAAAAVLSGWLSVGPRAAKFEELVAEQVGAKHAVSVNSATTGLHLALAALGIGAGDEVICPSFTFIATPNSIRYTGATPVFADIDERTYNIDPAHVEQLITPRTKAIMPASQIGLPADLHALRAIAEKHGIPIVEDAAPAYGATIDGVRLGTISDITVFSFDARKILTTGEGGVVTTDSDEVAAKLKALRAHAASISTLARHTTTAVIAESYDEVGFNYKMTDIQAAVGVVQLPKLDHVVKTRRALAARYDELLRDNASLVLPYEPEGFGHVYQSYLVRLVGHERIEVMTAMAQRGVATRRITACHLEPVYHAGDKNPSLPVTERVAADHILLPHFVGLTDEEQDEVVAALTAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T651</accession>
    <name>A0A7W7T651_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="501"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="929" mass="97677" checksum="C61E5724F393777A" modified="2021-06-02" version="1">MTRRVLDLVERQVLAAPDAVALVVDGVERTYRELDDLAARYAGLLRANGVRRGDAVGLLLDRGADLPAAMLGVWKAGATYVPLTAATPPARIAKVLATADAKVIVTDAAERVAEVFSGTVVPAADVAGAAPADTVPGDGLDLAYVMFTSGSTGEPKGVQISHGALINLLKSMERLVGSRPEHAWLASTAVSFDISALELYLPLITGGRIVLAGDTQAADGGELLKLVDKHAVSHVQATPSGWKLVLAAGFPPPHVVALVGGEALPETLATRLRPLVARLVNVYGPTETTVWSTSWDVPEAVDRVLVGRPIPNTRLYVLDAKYRRVPVGVTGELYIAGDGVARGYANRPDLTADRFVPEPFGGNPGSRMYRTGDLARFTRDGSVDFLGRADHQVKVRGHRIELGEIEAGLVAHPAVADAVVVARGDEEGGHSLVAYTIPAPGASAEPAELAAHLAQSLPEYMIPAAFVTMTAFPLSAAGKVDRKALPAPDRTALGASKPYQPPATDTERRLAAMWSRVLGVEQVGRDDRFFDLGGDSLRVVRFLAVAKEEGVELSLATLYRHDTIANLGRMLDGDSSSSAEEGFPSPLGMMAEHHVPAVSIAVVADGEVVSAFGYGELTPGGGPTTPDTLFQVGSISKHVTAVAVLALASQGRIDIDTDVNEYLTSWQVPYPPDAEPITAALLMANLSGLSETSNEQYHRDAAMPTVLDLLQGEPPADPPRVHVVSPPGTEFVKHNTHYAVLQQLVVDVTGQPFPEAMRTLVLDPLGMDDSGYAVDHPLTSGRPVALGHDEHGVVLDGGWRNRSTAACGGLWTTASDVARVAAEIRSAYLGRSPRVLTRAIAERMLTVAHEGSLFGLGTSVDPTGADLEFGHIGESPGYRAVTLTGITAGTGLVVLTNSDNGREAHKFVAAHADRLVGDLGTGLSAAHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6R5</accession>
    <name>A0A7W7T6R5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name evidence="3" type="ORF">F4559_004735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36460" checksum="881314EFF63DA096" modified="2021-06-02" version="1">MIRVAVVGAAGYIGGELLRLLVSHPDVELAAATSRSLQGRQIDGVHPNLRSRTTLRFSAEDELDHYDAIFLATPHRETMARMTEFLGLARTVIDLSGDFRLASTAAYEDYYGTPHTAPDLIESFVTGLPELHREALRTADRISVPGCMASAGILALTPLAHAGLIRGEITVDARTGSSGSGAKAGSENLHAERSGALRVFAPTRHRHEAEISQATGLPVRMTATGVEAVRGVQLVSRAHLAPDVDERDIRSAYRAAYGDEPFVRVVAHRRGLHRFPDAKILSGSNFCDVGFALEAGSPQVTVISALDNLVKGGAGNAVQCLNVRYGLSERAGLEFTGLHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S8</accession>
    <name>A0A7W7T6S8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_004972</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="338"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4967613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="555" mass="60455" checksum="C0228D70C864BB80" modified="2021-06-02" version="1">MPAVPTTPFQYRDVLPLAKDTRTEYRLVTSEGVSTVEAAGRTFLTVAPETLTLLAKEAIRDIQHLLRSSHLTQLRAIVDDPEASGNDRFVAMDLLRNACISAGGVLPMCQDTGTAIVLGKRTESVLTGGTDEEALSRGIFDAYQELNLRYSQMAPVTFWDEKNTGTNLPAQIDLFAAPGTEPKYEFLFMAKGGGSANKTFLYQETKALLNPSRLAKFLDEKLRSLGTAACPPYHLAVVVGGLSAEQNLKVAKLASARYLDDLPTEGSPLGNAFRDVDLEQQVLELTRNFGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIAVSCSADRQVKAKITPEGVFLEQLERDPARFLPDVRGEDLSDEVVRIDLTRPMDEIRATLSSLPVKTRVSLTGPLVVARDIAHAKIKERLDAGEPMPQYLKDHPVYYAGPAKTPDGYASGSFGPTTAGRMDSYVEQFQAAGGSLVMLAKGNRSRQVTSACDTHGGFYLGSIGGPAARLAQDCIRKVEVLEYPELGMEAVWRIEVEDFPAFVVVDDKGNDFFAETSAPTLQISFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E2</accession>
    <name>A0A7W7T7E2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">obg</name>
        <name evidence="11" type="ORF">F4559_005288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="160"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="353"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="316"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="485" mass="51053" checksum="EF4A8C48F43A788E" modified="2021-06-02" version="1">MSRFVDRVVIHVAAGDGGNGVASVHREKFKPLGGPDGGNGGRGGDVVLVVDSQVHTLLDFHFRPNATAGNGKGGQGGNRDGANGADLELRVPDGTVVLTESGDLVADLTGEGTRLVAAQGGRGGLGNASLASKARKAPGFALLGEPGEAHNLVLELKSVADVGLLGFPSAGKSSLISVLSAAKPKIADYPFTTLVPNLGVITAGETIFTMADVPGLIPGASEGKGLGLDFLRHIERCAVLVHVVDCATYEPGRDPLSDIDALETELAEYTPSLAGDLAERPRVVVLNKIDLPEARELAELVRADVEARGLPVFEVSTASREGLRELTFALARVVEEYRASRPKQEATRIVLRPTAVDDAGFTVVEDPETPGGFLVHGERPLRWIRQTDFTNDEAVGYLADRLARLGVEDVLVKKGAVPGAQVTIGDLVFDWEPTTPAGIAMTMSGRGTDARLEPMNRVGAAERLAAKKSRRIPGSYADEDFEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T810</accession>
    <name>A0A7W7T810_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_005652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="12">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="13">
        <location>
            <begin position="325"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1054" mass="112840" checksum="56B925E10E9E7556" modified="2021-06-02" version="1">MAVDRAPLLVRPAPQERPERHWDTPARAVLDHGSGPVRVLGGPGTGKTTLLAEVVADRVLRRGVHPENVLVLTANRRAAVAMRAELTRLLARPGEAGVLPTTQEPLVRTVHSYAFAVLRARAVLAGEPAPRLLAGPEQDAVVRELLLGDVAMGAENWPDRLRPALTLPGFAAELRDLLSRATERGLAPEDLLELGRVHGRAEWAAAGSFGQQYEQVNLLSGAGQGLAPTYDAAELVGGALLTFETEPDVLDAERRRVRHLLVDDAQHLDPVQYELVRALGTAAREFVLAGDPDQAVFSFRGADPAVLTSFDGPTVVLRRGYRMAPEIRDAVARVAGRLPGVSPTRDVTPVPAVGAVQVRLFASAAQEAAWVADRLRRAHLIDEVPWSGMAVVARSATRSLPVLQRALLAAGVPVSVSADELPLAQQPAVMPFLALLRCAAVPGTLDEDTAAMLLSSALGGADPLALRRLRRGLRRLDLAAGGDRASGELLVEVIESGDRLAALEAAEAVPARRIAGLLRRARKAMADGLSVEQVLWELWQATGLEQRWVAQSARRGTSGMQADRDLDAIVGLFESAAKYVDRLPGASAEGFADYLAAQQFVGDTLAAAAPTGEAVTVLTAHAAAGREWTVVAVPGVQEGSWPDLRLRGSLLGVERMVDVVSGVDAEHVSPVAPLLAEERRLLLVAASRARRTLLVSAVRGEDEQPSRFLDELEELSGEEGERPTFKPERGLVLAELVGELRRVVCSADESADRRGRAATQLARLAAEGVPGAHPDSWYGLGSVTSESPLWTEEHTVSVSPSTVEVLAKCPLRWVVERHGGQDPAELASITGTLVHALAQAAASGADEKQLREQLDEAWAAVDAGAPWFSRRERIRVERMLDTFLTWLASSRAQLTQVAVEEEISVEVPRKEGGPWLRVRGRVDRLETDRDGRPVVVDVKTGKSPVTRKEAEQHPQLAVYQLASALGGFTHLGLATEPGGARLLYVAKENAKTGATELAQKPLDEQGVRVWLEAVQAAAGSSVGPAYQATENPDCSRCPARTTCPLHESGRQVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T888</accession>
    <name>A0A7W7T888_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="398"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="46410" checksum="B420E0309634A677" modified="2021-06-02" version="1">MSTFAGIGAALSALTTNRRGLEVTGQNIANANTEGYSRQRLNTEPAGTMAPGRWARASNFEGGVNVTSIARLRDSYLESRGHVEHERQASATGRLEVLSEVQTVFNEPGGTGLQAKLGELWAGFADLADNPGDLGARTQLLTRAKDVATALNSGAGELSDQFSAQRAAMTDTTADINTKAARLADLNDAVRRARQSGGTGNELADQRDLLVMNLVEATGAKAVTAADGSVGLSLGGGWLVQGATARAVDPAGATTLSGQSANPVGLVWQDTGTAVSGVGGAMGATLSGLNNTLPDYAAELDKVASALTTSVNTVHTAAFTKAGVAGGAFFSGTTAAGISVAITNPADIAASGSATKALDGSAADKLSELANSATGADVAYRTAVSKIGIEANSAKTVLNTQTAVTDTIDSARASESGVNLDEELTAMLTYQRSYEAAAKVMSAIDSMLDTMINRMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D0</accession>
    <name>A0A7W7T8D0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="29602" checksum="30D8C4A8EBC74E30" modified="2021-06-02" version="1">MHALWVVLLSLLTAGYFALAGFDYGVGLLARFVGRDEAEHRRVLRAMTPFFLGNEVWLIAAAGVLFGAFPRLEGELLHAHHGTVVVLLCGLVAFTAAVQLRGTAPLWDVPLVGGALAVAAGWGVLLGDVVGGSPVLWAAGMVALFTLHGAVFLAWRLQGPLRARAIRYAGWAAVASGVFVVLALALGATVREPVLGVLGAVVAAAVLIGLRFALRAGAFRVAFGCSAAACVLPVLTVFAAQDVVTPEVMAHASTLRALSWVALAVIPVALAFQAFTWRLARAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W4</accession>
    <name>A0A7W7T8W4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase</fullName>
            <shortName evidence="8">DHK-MTPene dioxygenase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="8">ARD'</shortName>
            <shortName evidence="8">Fe-ARD</shortName>
            <ecNumber evidence="8">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="8">ARD</shortName>
            <shortName evidence="8">Ni-ARD</shortName>
            <ecNumber evidence="8">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtnD</name>
        <name evidence="9" type="ORF">F4559_005501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 1 Fe(2+) cation per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="8">Binds 1 nickel ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="8"/>
    <dbReference type="EC" id="1.13.11.53" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01682">
        <property type="entry name" value="Salvage_MtnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023956">
        <property type="entry name" value="ARD_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="PTHR23418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="1 8" id="KW-0533">Nickel</keyword>
    <keyword evidence="5 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in metal incorporation in vivo" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="site" description="May play a role in transmitting local conformational changes" evidence="8">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="site" description="Important to generate the dianion" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="20865" checksum="628C75B88F2E258F" modified="2021-06-02" version="1">MTLLTVWPDTDPATVVVRTEDPDEIAAELEALGVRFEQWPVLPGVTRENALEAYADQVARVTETEGYVLVDAMEMTPSDDPGWLSTAAAARLKFLAEHTHDDDEDRFFARGSGVFYLHVGDRVYAVLCEAGDLLSVPENTTHWFDMGTRPDYVSIRFFHDDDGWIGNFTGSEIAKSFPTFDEITAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y7</accession>
    <name>A0A7W7T8Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="29147" checksum="3CB6E98AA9037F52" modified="2021-06-02" version="1">MLGVVWRQVGAALDRAALVCVELGVVTGALGEANDLLGSLRVEGFARAVVAAWHLQERYLVAERSLESYFGRLGMSRPPRTVEFPGRPAVVGVDPRIYFRPVVIEVPRIAAGVPDLRGAGWAERVRWELPAWDLGDKTEGKIYDESAKCWKLLSGVDRAESLTGEARYRVLKAIRDGLAPGDPKYAKGLGIAATHVETKAAVWARRTGRALVDVVTNRNYVCGQAYRPGISSVTAGCAQAVRLILVKGQTMRVWCDGREVPLIIEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T975</accession>
    <name>A0A7W7T975_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="40039" checksum="6F6094221CED8E20" modified="2021-06-02" version="1">MSHLNEMFAKIAENNDEIISAYAARRAVDDARKQATRRTDQRAFRAQLREMPPFRRTTGPAPQHRLRATLRASLNDAIAQQIITFNRAAHVELDPAKRPKALVWTTERVEQWQRTGEKPSPVMVWTPDQTGDFLDLVHEDRLYARYHLIAFRGLRRGEACGLRWADVDLNAKTATVATQLVLEGWEVEEGDPKTSSGARVIALDGETVKVLRAHKAQQAAEKLKWGEAWIDTGRVFTEADGTLLHSGKVSEAFEKIVRTSDLPPVRLHDLRHGAATLALAGGADLKTVQEMLDHSSITITSDIYTSVLPEVAHRAAEAAAQLVPRRSTGTDGHTSGTHDARDGSALLLVANPGNEKRPGQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H1</accession>
    <name>A0A7W7T9H1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19866" checksum="4A08ACE145679AAE" modified="2021-06-02" version="1">MDSPDAALADRVARGDALAFEQLVLRYSGRVFGVALRMLGDRCDAEDVTQEVFATAWNRLGELEEPAAVRTWLFRVAERRCLGILRARRCAAVGELPDSSTPLCTPAYRDPARVTETFAALTHALSALTEFQRVTWLLAEVHGLTYAQIAIAVGATEESVRGRLCRARSRLSDAMRNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H8</accession>
    <name>A0A7W7T9H8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-subunit dehydrogenase-like oxidoreductase (DUF2520 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="150"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="30227" checksum="DCE464CA2719C72C" modified="2021-06-02" version="1">MDATPRPARLAVGVISAGRVGSVLGAALARSGHLVASVSAVSRDSLCRAEELLPDVPVLPPPDVAASADLVLLAVPDDELAGLVRGLVATDSVRPGQIVVHTSGAHGVEVLAPAARAGALCVALHPVMTFTGRSEDVQRLTACSVGITAADGDEAAWHVGEALVVEMSAEPVRVPETARPLYHAALAHGANHLITLVADCADTLRAAGVQDAERVLGPLLSAALDNVLRHGDRALTGPVARGDAGTVAKHLAVLADSPTLPAYRALARRTADRASAAGLLKADLAADVRSTLDEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9T8</accession>
    <name>A0A7W7T9T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="47470" checksum="A0B47E06C4EB8CB1" modified="2021-06-02" version="1">MTTRAICHIPSGEMLRLQPVSHWLGRFSEFARRSATEIVLPAVGFQGPLFQSEVHSVPAAYRGTNHLTKWVRDSRESLGEGGVVWANVIIDGEFLRNELIWQRNQYGAPLAQVCIQHPVAQATFRKMISEVIALGVDGIVVDVTDAYPNSGSADYSGISAHCFCDYCMDALALKGFHEPKRAFIGDDSFIRLGLRLDDDGAAHIDPPQSWIDERDTDSLIAYALARRFVTGEPAAHQADALRMYSYLAARVAVTAEAVRSLLLPCREENIRTAVVMGTAACDWSQMVTLPAMDTAKAADEYWLPDAPDRDHSPGEWRAVQFLAGRSTYYFNLFFQRVEDVQDRMSTLGVDTFIRRLEAASKRLQANRLSSGAAFTASLLNQFEGFVGIPLGRQDRLELVGRLTREMTDVAPHHEALTRFRNTEPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U4</accession>
    <name>A0A7W7T9U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinol monooxygenase YgiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13369" checksum="896525DEAD9FCAD8" modified="2021-06-02" version="1">MLLACRFTVAEADASAFTDRVAKALALLTAQPGVRAGRLTRSTDQHDLFLLTVEFESVPAYRRALSPFEVREAVVPLLSTAHPEPSAFEPLLDAESGDVRQSESLVAADAFTVRLGEAAGPTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB5</accession>
    <name>A0A7W7TAB5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40888" checksum="798BFF3A2BFE6DE5" modified="2021-06-02" version="1">MSGAIGPIVEAAVAADQERWRKQRSVLVRDLTALERRAVDRYAPAWRVPDTSVLAAPGWIPAEPIPLTEVVLDWRDVPPPVITGTEAELRAVLPLRSPGRAFSRYSAAFRYLAPPRLFENRPSYRLLDVGPGAGRLTFGSTMYFDVLDVSEALGHEFAVEPHGVLPFRSLVGDPFDLGRRAVGTSIGTLTIRRGDPPTFLMLYRDPTRVASGGGQYGVVPAGEFQPAGIASESLRADLDLWRNTVREYSEELLGEPEHDGTTGRPLDYDVWPFHRDLTTARDEGGLSAHLTGVVLNALTLHTTVCTVVVFEPEVFDRLFRDRVVDNSEGRVVEALAFDEPTVRRFLDREPQGATSAACLALAWAHRERLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC4</accession>
    <name>A0A7W7TAC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="446" mass="49205" checksum="C33057774D823D2A" modified="2021-06-02" version="1">MGKRQGLTRARKAAGFTQESFAEAMGVDRSAVVRWEAGSRSPHPHQRSRLSTLLGITMGELDQLLDVPLPAMPVVPAPMPEATVAADQERWREQRSVLIRDRTALAWRARALYDQAWHLPDAPVLALPGWIPVEPIPLTEVVLDWRDAPPPMITGTAAELRPVLPLRSPGRAFTRYSTAVRYLAPPRLFENRPSYRLLDVEPGARRLTFGAMTFFDKYDVSEALTHELAVAPVGEGWSALPFRSRLARPFDLDTRPVGTSIATLTIRRGDPPTFLMLHRDPARVASGGGQYGVVPAGEFQPAGIASESLRADLDLWRNTVREYSEELLGEPEHDGTTGRPLDYEVWPFHRDLTAARDSGGLSAQVLGVVLSAPGLNAAICTAVVFEPEVFDRLFRDRVADNAEGRVVEALAFDEPTVRRFLDREPLGATNAACLALAWAHRERLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAD2</accession>
    <name>A0A7W7TAD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolate oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="455" mass="47519" checksum="CE5206A915AC0FF7" modified="2021-06-02" version="1">MRPLLARLRSAVGDDAVLADEDVTAAYRRDMMPLAPAGKPAAVVLPADAGQVCRVVRTCADAGVPIVVRGAGSGLSGAANAVDGCVVLVTTRMDRIVEIDPDNRLAVVEPGVVNLDLRTAVERHGLFYPPDPSSYDWCTIGGNLATNAGGLCCVKYGVTTDSVLGLDVVLATGELLRTGRRTVKGVAGYDLTRLFVGSEGTLGVITRATLALRPLPQAPMTLVATFTTTRQAGDAVGRVVRAGVVPSLMEIMDRTCVEAVERHLRTDLGGGAALLVCQSDAGGEAALRELAAVAKACEAAGAELVHSTDDPAEGRDLLTARRSVLPALEAYGSWLTDDVCVPRDRIADLIVGCEGIADDTGLRIAVLGHAGDGNMHPTIVYDPATQEAAARLAFDRILDLGLELGGTITGEHGVGKIKQDWLARELGPVGLRVHRDIKHALDPTGLFNPTSMLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAE2</accession>
    <name>A0A7W7TAE2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_006356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="41960" checksum="1AC6EECA56D13E19" modified="2021-06-02" version="1">MSTLKAVPSDVRAGFTWLTGHRAAVLLAPALLYLLVRELGLLVVQAMAARWDKDVTKALTSWDGQWFLGIAERGYGNVPPWLVDAFGRRDPSTALAFFPGYPTLVGWVDALPGVGSVGAGFTVSFVAGVCCAYGLERLGRAVSGGSRRVGLVLVVLFAASPMAIVLSMTYSEALFCAYAAWALVGVVERRWLLAGVCCASAGLVRPTAAALVLAVCLAALLAIRRREGWRPWVGAAIAPLGLVGYLGYVAVRTGRWDGWFALQQRGWDSRFDGGAATWRFAKLILGEPRSVLELATVWFLVGALVLVVVCLRRRVEWPLVVYGVGVLAMDLGSNGLMNSKARLLLPAFTLLVPVAVWLAGRRTGTVVAVLSGVAVFGTWFGAYAITAWQYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH2</accession>
    <name>A0A7W7TAH2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031540938" evidence="2">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20741" checksum="05260287A861520D" modified="2021-06-02" version="1">MRRALPFLAAALVLTACAESTPGTPSAGSAPTTTASGSSQPSGSAKPSTSATPKKRPKTINIKDVDPCTLLAASARQQLGLDAEPKATRNDLYRSPACDVGRRDFKYSVQIVTVTTVGLNWYFDGSFDVEPTAAEIGGFPGVYATNAKNPFHCYAAIDVSDGQMVDVLASSLGQNLKPDQLCELARNAATEVVATLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB03</accession>
    <name>A0A7W7TB03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MocR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="44307" checksum="E3702F3B24A1AE8B" modified="2021-06-02" version="1">MTASEIRALFAVASRPEVVSLAGGMPHLAALPMDSLSGEIGDLIAQDGLVALQYGSAHGVPTLREQICEVMALEGIHGHPDDVVVTVGSQMGLDMVTRIFCDPGDVVLAEGPSYVGALGSFAAYQAEVVHVGMDADGLVPENLRQAIAAVESSGRRIKFLYTIPNFHNPAGVTLAVNRRAEVLEICRRHNILVVEDNPYGLLGFDGVTYPALRSTDPDNVVYLGSFSKTFAAGLRVGWVLAPHAVREKLVLAAESATLCPPTLNQLIVSRYLAKHDWKGQIKVYREAYRDRRDAAISALEQHMPLGSTWNKPNGGFYVWLTLPEGIDTKAMLPRAVTQRVAYASGTGFYADGLGSRQLRISYCYPTPERIREGVRRLANVIKDEMELHETFGATSGRAVTGPQTPAPDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT10</accession>
    <name>A0A7W7WT10_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD superfamily hydrolase (TIGR01490 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="30686" checksum="53FB752256405BBE" modified="2021-06-02" version="1">MEGTAERERLAELAGQASAEAALAVGPGLETAAATDLTAAAFFDVDNTMMMGASIFHFARGLAARKYFKNSDLMGFAWQQIKFRVGGREDPQSVKASREQALSFVAGRSVAELVALGEEIYDELMADKIWTGTQALAKMHLDAGQRVWLVTATPVELARIIARRLGLTGALGTVSESEDGIYTGKLVGDLLHGRAKAHAVRALAAKEGLDLRRCTAYSDSVNDVPMLSVVGTAVAVNPDSGLREVARKRAWEIRDFRTGRKAAKIGVPSVLGAGAVAVAAGLAYRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTG4</accession>
    <name>A0A7W7WTG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12773" checksum="19AACEE5A064B3A8" modified="2021-06-02" version="1">MASISHRVTIEVLGDDPAEVDAEARRLLAELEALDYDPEFAKGPPPPPDTKGWDPVSVTTVVVTVTGPQAFLLLGRTLHAWASRDRHRRLRVDDGGEPVEVSGEDPMRRFFSREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI0</accession>
    <name>A0A7W7WTI0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase (TIGR01509 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14491" checksum="133E1490CB80D17C" modified="2021-06-02" version="1">MRGLVLDFGGVLTDHGDDVDVAEPPLLTASRVAHKHGIRTAILSNADGLWAPPASWHDVFDTVVTSGEVGIAKPDRRIYSLVAGRLGLELGECVFVDDVPMNVWAAVDAGMVGVHHRRVRDTLAELEVLLDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTK3</accession>
    <name>A0A7W7WTK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12758" checksum="4882629DB38F63A8" modified="2021-06-02" version="1">MPPRIRPLPDTWTTPDHDHVAGAQALVKIMVEVLSGHRPLTRLADHTTRTARDTIRENLDTGPIRATRVHLRPVSPTICEATGTVVDNGRLRAMLLRAELTPTGWICTRFRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT9</accession>
    <name>A0A7W7WTT9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6961" checksum="1D8D5D9B65FF7C12" modified="2021-06-02" version="1">MSDTWTWRKSSRSVGNGDCVEVGTSVDAAAIGVRDSKRGDSGPVLLFSHDGIATFFASAKAGKFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX5</accession>
    <name>A0A7W7WTX5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="33538" checksum="62CC7B8157BDE640" modified="2021-06-02" version="1">MTRPDPRKTAALSAALSGAVDLGALKARADAARQRASAPPPTPSDAAPSPWVLEVTEATFQSVVERSLEVPVVVELTASWSPEAGQLSPVLEKAARAAGGAWLLARVDVDESPRIGQLFQVQSVPTVIAVAAGQPVDGFAGPLPEKDFAQWIARILDALRDRLPGIREAEASGDGGAEVVEEPADPRFLAAEDAFEVGDYAAAEAAYEAILSAEPGNEDAKAALAQVRFAARAEAVSADAITVADAAPDDLDAQLAAADFEVATQAVEQAFKRLVDTVRRVYGEDRDRVRGHLIALFDLFPADDPRVAAARRNLASALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUB5</accession>
    <name>A0A7W7WUB5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="22792" checksum="D3D3C91C5D1FBFB5" modified="2021-06-02" version="1">MTADGRRLAGVPTGPGYASHAVLTEPVEVPDTLSDHEAAALLSQGTTALAAARAGRIAPGDRVLVEAATGGVGSLLVQLASRAGAIVVAATRGAHKLAIASQLGAHEVVDYSVPGWSAGLEPIDVALSSVGGATARESFDLLRTGTGRLVLFGYAGGAPLDVDASDVFGRGVSITGLWGTYSTDAVREAFASGLSPILGAALPLSDAARAHYLLESRSTTGKLILVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV81</accession>
    <name>A0A7W7WV81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="17871" checksum="C99B6BBD744D589C" modified="2021-06-02" version="1">MNSFDVNGHYFSPATRTAMTHLTSGDTAPFEAAAAVRVAAHAVDRLRSRGTESRGLSPAALDLLVRLGVAGEPGLTIGDLAASGGISPRNATGLVDTLEREGLARRSPDPADRRAVRVAITPPGRGWVEAFRKPSEVAMAALFRDFTDEEVVLLRHLCLKLVTGAEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV85</accession>
    <name>A0A7W7WV85_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="173"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="490" mass="51397" checksum="47B36376D464294F" modified="2021-06-02" version="1">MTTAIRLVCALLPVLWAGVTSWVDRFSVVEVVGYGTAVAVALVAARRHPAGIVLAAAAWQVGVLSRLGSDNSVPLAALSPALVLTAYVAGRHVGHARAAVVALVGSGLVGAIAGAVVTGTPDTVVLTLAGIAVAGAVPWAFGRHRRLFAAMVEAGWDRAERLERDVVRARDRERARLAAEMHDLVGHELARAALLVGALEVSPTLPDDQRRAAHEARAGVTAAAERLADTVRLLRGPESRSPDESVQAVVDAARATGLDVDADTADLAGVDPVIDRTVHRVLAESLTNAMKHAPGSKVRITLTRDDGITLVVANGPPAAKPTHTGSRLGLVGLTERVSLVGGRFDAGPQGEGFAVHAHLPERPVATEPTRSSAATRVRHSARHVTLVTVAVVGGAAVLALGYMVFDAVTSTLRPAVYDRLRVGAAQADVLPLLPDRTRVDGPPVEAPPPDWTCSYYSTHPNPFDGRRLDLYRVCFADGRLVGKDLLTRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV87</accession>
    <name>A0A7W7WV87_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dyp-type peroxidase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="537" mass="58140" checksum="61724FB7EDD2E87E" modified="2021-06-02" version="1">MTMPGPRRAEQVRPDTEPMLDADEIQGNVVPGFLKPHLAVLAFTIADPAAARRWCRLVADHVTTLRHAMGSRERVRSLIASRTAAKLNALEAGGSFRATGEVGALLVEGGVDDTWTSVAFSHEAMGKLTDDPGVDEFADRGFVLGMTARSGALGDPAGSTDGWVVRDPDVLLVVAADREENLRRHAEDMVALAESHAVRLVYREEGHKLDEVGREHFGFQDGVSQPGVRGRYAPDRFVTPRHVVDDADQRPEAWLYGRPGQHLVWPGEFVFGYPGQGSDPILAGSTASRGPAWSRNGSYLVFRRLRQDVAGFHEFLDHAVTQAGPGVTRDKLAADVVGRWPSGAPVARTPTRDVPELGVDALRNDHFGFGSDSRTLRLTDGSTTNGLYPEAGADPVGLVCPQFAHIRKVNSRTAPNDAGGLTASFTRRILRRGLPYGKPTDEDRGLLFLSVQASIVDQFEFLNTRWMGDRTNPRAPGGHDLFIGQNGQPGEDRVRSATLLRPDGAHPVTAPRDYVTATGGGYFFVPSLSALRDVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV92</accession>
    <name>A0A7W7WV92_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031289868" evidence="1">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="37"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="40127" checksum="FC9D98B251D50A8B" modified="2021-06-02" version="1">MSGARLGRVLAVAAAASLALSACAGSGGGGGTGDASEIKIGFMGDLTGEGAAIVIPPYNGAKLAVDEYNAKNPKIKVNLIKYDTQGKSDQATSLITKAVGQDKIAGLIGPAFSGESKAIGGQLEENKIPSVSPSATGTGLAKNGWTYWHRVVANDDDQGPGIADFLIKAKSPKKAFVISDDQEYSVGLAEAVAKSFTAKGVTVETDKFAKDASDYSSTVTRVKSSAPDVIVYGGYYAQAGKLLKQLRDGGVTAPFTSGDGSLDAQLVAAAGKEAAEGAILACPCNIPYANATGAQKTFFDSYKAAYKTDPAIYSTEGYDAASTFLKAIDAGKTTSTDINEFLKTLTFDGVSKKIKFKSNGEPETSAVFIYQVKGGALKLLGLASEAKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN3</accession>
    <name>A0A7W7WVN3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD/FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="46100" checksum="65B8FAEE0BC2825F" modified="2021-06-02" version="1">MVDHGDRPRVAVIGSGVSGLTAAYLLQRRYDVVLFEQDDRLGGHAHTHEIVGPDGRVTPVDSGFIVHNERTYPHLVRLFGELGVSTQDSEMSMSVRCGGCGLEYAGARKLAGLFARPRNLARPAYLRMLAEVTRFHRHARRLLALGDEHDTTLGAFLAIGGYSAYFVDHFILPLVSAVWSAGPEVGRRYPARYLFEFLANHGMLSIGGSPAWKTVVGGSNAYVQRAVKGLTAVHVSTPVRSVRRTAGGVEVRDDADQRHAVAKVVVATHPDQALRLLADPTDAERAVLGAFRYSRNETWLHRDTSVLPGAPGARASWNVLKPDCHEPGGPVLVSYHMNRLMRLDAAEDYVVTLNAGDRIDAGTVLARMVYEHPVYTPESLAAQRLLPGLDDGTTAYAGAYHGWGFHEDGCASGVRAARGLGVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW2</accession>
    <name>A0A7W7WVW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="39" mass="3944" checksum="88688B6784F7D081" modified="2021-06-02" version="1">MTTTCLPCADPRSPSPTDGGRTIAYLTADGGVGLWHPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW62</accession>
    <name>A0A7W7WW62_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="8">
        <location>
            <begin position="241"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="323" mass="33709" checksum="DAEF4B5ED9EBDB18" modified="2021-06-02" version="1">MGRGDGHGHGHRKGLRWKPHRHTTADRVDPALEGSRKGVRALVLSFAALAVTAVVQAVLVVVTDSVALLGDTIHNFADALTAVPLGIAFVLGRRAATRRFTYGLGRAEDLAGLVIVLLIAGSAALVGYESVLRLVDPRPVAEVVIVAAAGLVGFAGNELVARYRIRVGRGIGSAALVADGLHARTDGFASLAVVLGAVGVAAGFPLADPIVGLGMTAAILLVLRDSAREVFGRLLDAVDPATVDLAERHARDVPGVVRAERLRMRWIGHSLRAELAVLVDPVLDVAAAHRIAHDVEARLKAEVPHLGAVTVHTEPAERSVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK0</accession>
    <name>A0A7W7WWK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="52"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="513" mass="56112" checksum="0C4BBB671CBFB118" modified="2021-06-02" version="1">MTAEPVRGGTIRILRDAGYDHLDPQRTATLQALALGQLLFRTLTAYGPDGQLVGDLATSTGRDVDGDGRRWEFVLRRGVRFEDGTEVTAADVAYGISRSFAAEITDGAAHLRNWLLENGSYAGPYVDGPDVPGLEVKDPWTLVFHFPRPRPELPFAVSTPVTAPVPRDRDTRASYDQAPIASGPYRIKSHEPGISLVLERNPHWDPETDPLRTGLPDGFVVEMGVDQESQHRRAIEGVGDDAYAVGENHAPRALAERYVGDPAYASQVHHDPTPLVWHLAINTQRVTDVDVRRAIAHALDRAAILEVKGGPVLGQVAHTLLSPVTAGYRDYPDPYPYDPARSAALVAGEFPTLRLISRSGREFVEFSSAVRDSLVAAGFTVDLDVVDRPRHNPIVRTRGNEYDLYLVCLPGEWPSASALLATFDGTRIVEAGNDNWAYLDDPGINAEIDRINTLPAAEAVPEWSAVDERLIRDHVPFVPLFTYVYVGFVGPKVRGVYTSPALGTPVYTQAHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM3</accession>
    <name>A0A7W7WWM3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22785" checksum="0FC64C5907666EDD" modified="2021-06-02" version="1">MTVRVVIADDQEIVRTGLAMILRAQPGIDVVGEAADGVEAVRLARELRPDVCLVDIRMPGLDGIEVTRRLAGPRVDDPIAVVVITTFDLDEYVHGALRAGAKGFLLKNAGADMLTQAVHAAADGDALIAPSVTARLLATFAGRGPRPARPLDPLTDREEQILAAVARGRTNNEIAREFHISLSTVKSHVASLMTKLGARNRVEIALWAYETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX9</accession>
    <name>A0A7W7WWX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leader peptidase (Prepilin peptidase)/N-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
            <ecNumber evidence="4">3.4.23.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004218</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EC" id="3.4.23.43" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="70"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="20631" checksum="59F2B9C9A61FEC72" modified="2021-06-02" version="1">MSGGIWPLVGAVAAPLIASSGPRQAIVAVFPPRGRSVWEIAAIGLSLAGALMAVENRFAGSPLADAWCWLVLVGAWLAWSDWVRQRIPTFGTVALAVVGLALLARSGDDQALIRAVVAATVVLIAAIAVATVASLGGGDVKLLAAVSAYTGWWGWSHVLTAVIGALVLAAVTGVVLLILGRITPGTHIAVGPAIIGGALSSVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX39</accession>
    <name>A0A7W7WX39_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="257"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="36906" checksum="DCAB0CD2CBC3F494" modified="2021-06-02" version="1">MRPVPWLPPLLYGVVLLAGGYAGLAGLGDTRPVPFVGGLVALVVLDLLPARRLPETVLFPARCLLFLLVAWGDGAGMARVLFLLLPFTAYFAFGRRVALAVGVACLVFVVATLHLTVPGWAHHVEQVSDLVMFTIGLVLTLAMAAVAVEEQRGVVALAASAERNRVARDIHDGLGHHLTAVAVLLEKAEAFRDRDPDVVDGALRDARESARRALEDVRRSVRTLREPFRLAAALQDLTRGLAVTTTCEGDEDLYGPGEKLALYRAAQEGVTNALRHAEAGSVSVAVYCGASVASLVVSDDGKGFQGPEGYGLLGMRERVAQVGGRLDVTGAPNLGTRLTVTIPRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX40</accession>
    <name>A0A7W7WX40_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="12"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26728" checksum="B09B3EB4958827EE" modified="2021-06-02" version="1">MVAGTVGTAHAVRLEAVRKVYGSGDRAVTALDDVTVGLRRGAFTAVMGPSGSGKSTFLHCAAGLDRPTSGRVLLGDTDLSGLKEDALTALRRRRIGFVFQAYNLLPSLTVRQNITLPLRFAGARPDEAWLFEVVTRVGIADRLDHRPAELSGGQQQRVAIARALVTRPELLLADEPTGALDTRTGRQVLGLLRDLVDTTGQTVLMVTHDPVAASYAHSVLFLADGRLAGEIFEPTPALVVERLTRLGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXI3</accession>
    <name>A0A7W7WXI3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26561" checksum="A82EBFA634A97FB6" modified="2021-06-02" version="1">MTAPHLIWYLTEPTRAVVDLGRFATTRALLRSAPTGDGHTVLVLPGLAGTDLTTTVLRRFLVGLGYDVHGWGLGWNLGPSEPALRGMRELLGRLAARAPVSLVGWSLGGIFARELARERPELVRQVVTLGSPYRLTDLRDTRVNPLYRFLARLSSAVVAPPPAEAGRPPFPVPATSLYSKSDGIVPWRSCREEPGGHGESVEVVCSHLGYAHNPAVLWAVADRLAQPAGGWRPFVPPAGLAGMYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXV3</accession>
    <name>A0A7W7WXV3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding transcriptional regulator AlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6765" checksum="0600D023EB887EF2" modified="2021-06-02" version="1">MNKLWGMKEVAEFLGVPVNTLYQWRTKNYGPPGKRVGKYVRFVPDQVRAWVDSLPNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY01</accession>
    <name>A0A7W7WY01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxylase-like metal-dependent hydrolase (Beta-lactamase superfamily II)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="12"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24282" checksum="1BE4946A54D0AB36" modified="2021-06-02" version="1">MLVLGFPTGSLQANCFLLATGKGGACVIVDPGQDAEEPIADALREHRLSPVAVLLTHGHFDHCFSVAPVCDGNDVAAYVHPADRDLLSDPLKGISAQSRAFFGGNLEMREPREVRPLSDGAVLDLAGLTLTVDHTPGHTGGSVMFRAGTEEGGRLVLSGDTLFAGSIGRTDLPGGDHREMLASLRTKVLTLPDDTVVLPGHGPTTTIGRERGSNPFLLELGDDSPAAPHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY58</accession>
    <name>A0A7W7WY58_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (TIGR02679 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013495">
        <property type="entry name" value="CHP02679"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024466">
        <property type="entry name" value="CHP02679_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024465">
        <property type="entry name" value="DUF2399"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09664">
        <property type="entry name" value="DUF2399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11796">
        <property type="entry name" value="DUF3323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02679">
        <property type="entry name" value="TIGR02679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3323" evidence="2">
        <location>
            <begin position="30"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2399" evidence="1">
        <location>
            <begin position="250"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="42744" checksum="B408C48E3FE0E9E7" modified="2021-06-02" version="1">MRSLNGLDSAALRPLWRAVHDRLSSGRPVSRVKVGPLDEEQRAAVADLLGDERLPGEYTTVSVAALDELLISSVGAGVRDVVAVLSGPLEDRATRRALAGAARTELWEWVTRHPVVVAQPALLEWAGAVRRAGLVGGSVERTRDALDRALRVVAALPATGVPLPVLAESVLGDPHALDEGTRCAGLVLRALAVLYGVDPPGDAQERRALWERAGVVEDELSPVVLVAGLRLGGVGGGVLRVCADAGHVAALTLAQVRATSFVGTPEDVWVFENPSVLAVAVVRFGVSCPPVVCTSGWPNSAVIVLLRGLSTAGATLRYHGDFDGEGVRIAAHVMARTGAVPWRMAADDYLSALGGARVGTSVGRVTEAPWDGGLAGAMREHGSAVPEERVTARLLDELDDRGRDVGGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY82</accession>
    <name>A0A7W7WY82_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type arginine/histidine transport system permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="45" mass="4743" checksum="B5E9E4769F5E134A" modified="2021-06-02" version="1">MTDEIPRSIATGRRVALVLLVVAMVVTVLLAVVLIAADVTKPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA5</accession>
    <name>A0A7W7WYA5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1430"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1507"/>
            <end position="1526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1741" mass="174951" checksum="22787140497DD64C" modified="2021-06-02" version="1">MAARSEAQADVEVSTLVVPAWRLRWQAPELALVLGERAVALASARRDEVDRLRAEALVVFAGNRTGRGVRIADRAMDALKAAEAEGEHETAWRLRVELAECARTVGAPLTGFAAVRPVLEAADVPEGIRAAALVQASECLVTIGRGAVLTAALTEADRLHAADRGTEPDAVVLQRGELRAATAAQHRRWGDLDAAVATCREGLELLAGLADPSSDNGQVRGRLTLELVCALLDADRPAEASEVGTPLLELPVRAPSASTSGWLGLALATRVHLPAGRVDQAREMLRDVVACAERHQLDTLLAETLLALAHVHEVSGDLTEALADLRSAHAAERRRARAVYAVRARLAAEFSGVRRQPVGLHDQLAALLAAPTGGTATAGGATTGTASQDPPTLTPEIKQQLRQWRPVQVHRGEGLRVKRTRRAAEDMTVEGISAARAHAADRWRLVSPFGTDPAPTPPDPAAEAGTPEAATPTPGHPAGTPTPTSPPSTPADQAAALPATQTGTPAEPFGTPAPASVPSTAMPTWAVAPPHTSEESVGTPEPASPPPPARPTAPVDGPFESAGASASGSTPPAAAPSDASRESVGTSPSGSPPPAVLPAWAVAPPGVPTESAGPATGAAASPTAQPAWTAATPYTAAEPIGPSAQAPAPSTAWAAATPHGSSEPAAAAMRVSAPPAMPTDRAAAPPRTRTDSVDLSAHASGPPTARAAVLPHTPVDLVDPSPSAAVLPEASAVRSGESGGPVTNASAASSAHAATPPSVEPTSSAEPVGPSTHAPVLPASPASADPATHVPVHSPSPTASTSPSAEAPVAPTPDFPRATPDPEAPAARQGGRRRAPEPEDGEEPSRPHFAFSSDVRSTNTEPRNRRTRHADTGTANSEALPPPDPEFASTTWPVPVQAEPATSGRSTPALGAHSSEMDVSWREAPSPAFAADPARPRPAGPDRITSDPTTPSTGERSGLHASTASDSTAAGERESGLRGSAGSSSLDLRVPASGLIAAAGAVRSGRRRAAREAAEELAAADRSTEGNSGVLESLKAAGLLAPTRQGGRRRAPDSDPPTQGGESTAPDAAGEPARVGTADPWTPHPPDTATPAGADVHPTAYTAPAVPATDTAVPTPAAPDFEVSTPAVPAPAVPDSVAPFPVAPSPVVPGHAGSTPALPGPAAPTVAVPDLVVPGQVGTHPAEAASVATHSVEGPPAGFPEYGPAVATPDTGQVGAHRAQAHPTGRGVPSTDPVDPFSTASRFDVRPADTGPAGFSPTEAPRVDPGPAWAPSTGQGPATHEPPGFGAATFSDLGGVDFGHSGSPVPDPGTVRFDRSAVTGAGAVNTDQVETGAELPRRPSRTDQSTVDDFGPGGIDLFRSARMVEPSDDDSVPVGLGAAFVKGPVIPTARVPEPPVAPEPPEGSPFGLPVGSADPATRARTGVEVDAGAVARWPEVEPGGPSSGEFEQADGRESTGPVPVDAEPGRTALGGPGVPSTEPRPTDPTPGSPGPADREPGYAAPGRPEPTTPELTNPGPTNPEPTNPEPTSTEPAGLRLGDFTSGGPVPVGPDPASFGSGSPEPAGSESGGPASAGPVPAGRESGDFAPGGPEPAGPGPEGFVPGSPDPVGSEPGNPVSGSPEPGDSEGGDAEPLVTSVVVGGRVVELPPSPTMSPSAARAARRPKSDLSLAELLAEALVAYETGRREDEAAALTGTEAETTGPITAPVPESAVPPPSDAETTAPIQPVAAVRPRVDTWTLPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB7</accession>
    <name>A0A7W7WYB7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046282">
        <property type="entry name" value="DUF6319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19844">
        <property type="entry name" value="DUF6319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24352" checksum="D2671CA237214D5C" modified="2021-06-02" version="1">MAKSLSPEDVDQLRAELAAGRPPAVWFTAAAVGVEAGRSAKVVAFTEPAEGDFIQVRPTGTKDELSFSPAELTVEKPAPRKKVVAEPKPAREESVPAAPAPEEPIYTPVEYPYEPVPPEKPEKPTKQKSAPRKQSRPPGGEVTITLTSTPEGEWTVDLQWGSRRPLRATPVPPAAVGRAARQLLPEVAEAVDAVIETARERHLARVVQLRAELEEAQRALEELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM6</accession>
    <name>A0A7W7WYM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8997" checksum="494C3281AD7FA58B" modified="2021-06-02" version="1">MTTETDRIIKPRGPKREWLLRCEGEEGDIFSVTVSRGAVEIYPPDHLDCVHLERSQIAEFRAVLDEAIDQAESDLQSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ1</accession>
    <name>A0A7W7WYQ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-related sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="14665" checksum="03774EBA30245F66" modified="2021-06-02" version="1">MSHVHPAADPAAAAAFFAAELAFEADPDDVVRDLADGTAAGFRLVETRRPEAFARLRIPGAINLPHWEMDETTTADWDRDLVYVCYCESSECNAATKGALKLARLGFRVKRLAGGITAWHAAGHPTEGTGHGIACDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT3</accession>
    <name>A0A7W7WYT3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette subfamily F protein uup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="287"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="319"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="587" mass="63925" checksum="7C65D565EEDDAE48" modified="2021-06-02" version="1">MANLVNLESVSKSFGVRPLLDGVSLGVGEGDRIGVVGLNGGGKTTLLEVLAGVAEPDEGRVSRNRGLRMAVVTQRTELPEGSTVRNAVIDPLGFAADHEWAADARVRSILDGLGVTGFGLDAPVATMSGGERRRVALAAALVQELDLVVLDEPTNHLDVEGVRWLADHLLARRTALVVVTHDRWFLDTVCSRTWEVVGGRVEQYEGGYADWIFARAERARLADTLEEKRRNLARKELAWLRRGAPARTSKPRYRIEAAEALISDVPAPRDSVELLAFAKRRLGKTVLELEDASVVVGDRKLVDGLTWRIGPGDRVGIVGVNGSGKTSLLRSLAGELPLAGGSLVRGQTVKLAHLSQELHDLDGSMRVLEAVEEIARRVSLGKQELSASQLAERFGFSSQRQWTPVGDLSGGERRRLQLCRLLMAEPNVLLLDEPTNDLDIDTLQQLEDLLDSWPGTLVVISHDRYLVERVCDQVVALFGDGGLTDLPGGIEEYLRRRTEAQPVTTTAAAPKAPSTAADQRAARKELARLERRLEALHKREAVLHEALAQAATDPERLLALDAELRAVLAEAEDVETQWLTTAESTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ20</accession>
    <name>A0A7W7WZ20_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14018" checksum="EF4F4765DAF0BE16" modified="2021-06-02" version="1">MTATTVDGVAVVTDEPTPAPMRDNAGTPVLWKQTRTLTLADGRTVYGCAHCDYTSPNVHSVRPHLNKHRGDRVPAVPNVGALGALTLDDVVARLAEHDQLAAERDEWKIRAQRAEWSLSTLRTALRGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ68</accession>
    <name>A0A7W7WZ68_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein YcnI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08545">
        <property type="entry name" value="YcnI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012533">
        <property type="entry name" value="YcnI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038507">
        <property type="entry name" value="YcnI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07987">
        <property type="entry name" value="DUF1775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030534978" evidence="3">
        <location>
            <begin position="30"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1775" evidence="4">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="237" mass="24764" checksum="609D7F1D82048162" modified="2021-06-02" version="1">MSTKRFARGGAVLAAAGFLVLSSAGMASAHVTANTTKDPVQGGYTKVTLRVPNERPDAGTVKLELSLPAEYPLASVSTKPTPGWKVEAVKAKLDTPVKAHGREVTEAVRTVVWTAEPGVRIEPGQFNEFDISIGPLPDNTEQLLLPTKQTYSSGEVVDWNKPPAAEGAEEPDKPAPVLKLVKKPAGTESDHHEAAATETKAAGTDDTARWLGGVGLAVGALGLGFGVGAVLRSRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE1</accession>
    <name>A0A7W7SXE1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010840">
        <property type="entry name" value="YqiJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07290">
        <property type="entry name" value="DUF1449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20917" checksum="89718B37DD245D92" modified="2021-06-02" version="1">MGEFFSVALGFPTAVLSIPLVVVVGYWVVVAFGALDLDVVDVELGFGLAGTPAALSLSLLTAFSWFFCLGGAVLLDGWELSTALYLVIGFLLLIVAVLVGLILTRIVSVPLRRLLPDDKSDSRSAFVGRTCVIRTSSVTQTFGQAEVTADDGSSALVQVRQPGTDHLTAGSTAVIFDYDATGEFFWVTPLDTTLGGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE7</accession>
    <name>A0A7W7SXE7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12064" checksum="755C4FAE801DB3D3" modified="2021-06-02" version="1">MSDIKERFAEVVDGMVRDTAPRLFAVVQIYGDHADGRIAAWGMAFPGHVEAVSTEGSLHLSLRDTESITRAFTAPEEHLTATVVWLPAVNERLSDIDGFDHPEEGSAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY76</accession>
    <name>A0A7W7SY76_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24520" checksum="48F44D59A0722BEB" modified="2021-06-02" version="1">MSVVLLAEDDPAIAEPLSRALQREGYQVQVVGDGPGALDATAHGGIDLLVLDLGLPGMDGLEVCRRLRAGGRGIPVLMLTARSDEVDFVVGLDAGADDYVAKPFRLAELMARIRALLRRRAPGTLEVNGVRMDLAARRVTVDGQEVQLANKEFELLRVLIQRAGQVVNRDEILSEVWNDPELKSSKTLDMHMSWLRRKLGDVRSVERRIATVRGVGFRFNTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYC6</accession>
    <name>A0A7W7SYC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17521" checksum="23E767F37A411AF2" modified="2021-06-02" version="1">MRVYLPATVALLRDLVDRNEFAPVGGTGFALTPALRESYATGDTEELEYSAMLDAARASLRLIAAEDKPFYRRVVVSVDVDATVRPDLDFSVVKVSGPVPLSSIAAVHVDTGEAEDAVREAAEVIDAADLGDPDAEFVLGTAEDHELAWYVPQEIPFLLELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH8</accession>
    <name>A0A7W7SYH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polar amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031552178" evidence="4">
        <location>
            <begin position="27"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="64"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="32717" checksum="3C375DD8247D8C6F" modified="2021-06-02" version="1">MTAVRTKCLVALTMLLALVVSGCGTGETPLPGAAEKPSENPVAEVVKDDAAAALLPANVRDAGVVKFGVSVGGTGPSSYFSDDNKTPIGLDIDIADAVGKVLGVRVEREIASFENILPGLTSDKYQVGTGNFGVTEARKKTIDFATYINDGQGFAIRKDDTRFTEIKKLDQLCGLKVGTGAGTTFEATLEKEKHVCTDAGKPAYEVLSFSENSAIYLGLQQKHIDVIMSTINGLRFAATKQPNLKFLGEFKRLDVGFAFRKDSPLAPAFQAAVNKLIENGTYSKILAKWGTQDSAIPRSEISPPEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV0</accession>
    <name>A0A7W7SYV0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10222" checksum="47941FECEFA33C62" modified="2021-06-02" version="1">MITVTNVRIYAHGNWGTLLEVFPKGHIDDNRTTLACSDQNNPGRQAQFTAGTSYYISYDLPTGSQERWDGECFYDNGGTAPVEFRELDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ10</accession>
    <name>A0A7W7SZ10_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17508" checksum="B35A018E7978F936" modified="2021-06-02" version="1">MGCGDEQTHAHINRTYHRADAFLFGRYTYELFAGAWGSWTASDVPGWDPVLDALNTRPKYVGSTTLTDPVWSGTTVLSGDLAAAVADLKARPGGELQVHGSGALIRWLPVNELVDELTLLTIPVVVGQGTRLFPESGPDLVLDLVESTTDSKGVTIQVYRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ85</accession>
    <name>A0A7W7SZ85_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Succinate dehydrogenase / fumarate reductase flavoprotein subunit</fullName>
            <ecNumber evidence="7">1.3.5.1</ecNumber>
            <ecNumber evidence="7">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="7"/>
    <dbReference type="EC" id="1.3.5.4" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="42"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="6">
        <location>
            <begin position="496"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="628" mass="69086" checksum="822B6996C7CCA6DE" modified="2021-06-02" version="1">MYTEGDPIADHRAPTGPIETRWDRRRFTARLVNPANRRGRTVIVVGTGLAGGSAAATLAELGYRVLSFCHQDSPRRAHSVAAQGGINAAKNYRNDGDSVWRLFHDTVKGGDFRARESNVYRLAQLSTAIIDQCVAQGVPFAREYGGLLDTRSFGGAQVSRTFYARGQTGQQLLLGAYQALARQIDAGRVESHPRTEMLDLVVADGRARGVVVRDLVTGAVSTHLADAVVLATGGYGNVFHLSTNAKGCNATAIWRAHRRGALFANPCFTQIHPTCIPPAGEHQSKLTLMSESLRNDGRVWVPRDPADRRTPGAIPESGRDYFLERLYPAFGNLVPRDIASRAAKNASDPERGVYLDFADAIARLGADVVKARYGNLFEMYQRITGDDPYTTPMRIWPAVHYTMGGLWVDYDLRSTIPGLFVIGEANFSDHGANRLGASALMQGLADGYFVLPNVIGDYLADAPFGDVDPGGVEDEVRDRVARLLAVDGDRTVESFHRELGRIMWEECGMERTDAGLRTALRRIPELRAEFWSRVKVPGRGESFNQELEKAGRVADFLELAELMCVDALHREESCGGHFRAESTAGGEALRDDHRFSYVAAWEFTGGPPVLHREDLVFDHVRPSIRSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB4</accession>
    <name>A0A7W7SZB4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15380" checksum="119DD1D2C826A2E4" modified="2021-06-02" version="1">MSVRTVFRYLCDAPRCPVSATGESASSTPAGWSRLSSTAHLAGVRETRGTVSPSDRARGSFSLLLCPDHAQAFDGHRPVTDGRPPRPGRGAVAVHVACTCGGLSTYADAATVAGDTGGVPAHLPERAWWLHLPVALRWYTTREMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZH8</accession>
    <name>A0A7W7SZH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="670" mass="72017" checksum="34D862619BC40C96" modified="2021-06-02" version="1">MVNPLIRASKDAGGRVAKHAASRLAVAAAPVAGLAGDFALSCTLWGLATPESLPWMTLGIGATTAGMVVLVHHLDRRRNMLGRVFALGTPILVGAHQIAAVMAGPVSQPLLGVWGWAGASVTGAWIVRRVLRRTQDATEGARRSLWDEVSTKVGGALEGSAYTPKEKSEDRLAGPLSLEGGETVDDAQRSLSKLESVLRLPPGGARITPSPDDSSQAELTLVRRDMLRESTPYTEPSALGGTPAQPYRIGVYEDGRPMMLPLHRPGWGETALLIMGMTGAGKTFGAYVIFAEEFTRRDTYTIYVDTVKGAQSLGPLAEGIRWVIRTEAEAHALMRALRDKVVPARADYLGRRGLKNWEPGCGIPRLRVHIEEGSGLFLGDKAFVQSMERIRSVGVEFTLSMQRPSYVSLDVAARAQFGAVLCFGVAEQEDAAFAMPDEVLEAGADPSRWKNERPACCYLVAPGVDRALWTTPGRTLGISDDQLRMLARWARLHGDDLDAMTTAAFGELYTTRVPVESMVGAAPSAPAAPVVPPTPVPVPVVDDEDDEAPVRDLLGDDFEEPWRPGADDPDPSVQPGIDDPLPIGGTDGDWERPAGPKATPAEAAALFEQRLLELQAQGVEEIRAGDLVDVARKAVRSPAWVYKSLNGRVDTGQLERTDTGFRFVRELVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T013</accession>
    <name>A0A7W7T013_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ORF">F4559_001460</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="114"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="308"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="116"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4964101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="46460" checksum="388E393B32DC40C6" modified="2021-06-02" version="1">MGYLSGRHVLVAGAGVTGRSTADALLAAGATVTVTDRSPERLAELGAHVPGVTLLAAADAPPVDIDLVVTSPGWRPDNPLLAAAAAAGTEVIGEVELAWRMARELADPPTWLAVTGTNGKTTTVGMLESILRAAGIDAVACGNVGLPVVDALLAGRRVLAVELSSFQLYWSPSVRPLAGVILNLAEDHLDWHGSMDAYAQAKARVLTGDVGVANADDPLVSALLADAPARAHVGFTLGTPDEGQLGVVDGMVVDRAFGPDTVLVAVEEIRPVGPPGVADALAAAALARAHGVSPEAVRDGLRAFRPGEHRAVVVAEVDGVRYVNDSKATNPHAAGASLRSHDHVVWIAGGLLKGASVDDLVRAEAHRLRGVVLIGADREIIAAAVRAYAPHVPVHVLDDATMCDAVHTARTLSQAGDVVVLAPAAASMDMFRDYAHRGRAFAEAVETLVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T086</accession>
    <name>A0A7W7T086_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="20869" checksum="508457777491FF2D" modified="2021-06-02" version="1">MSGTGVDAESVTPGSAESETGSAGGAVSGAESSGETASENRAPGVPDPAVLAARRAKRPLWTVVVLLLAGAAALWGAAELTWVPGGTGVARTGAQEVTSLVPVAALSVAAIAAAVALAGWVRVLLGVPVACAGAAVAAAATMTDGPLAGRGLALVGAVLVIAAGVVLFARGRAMPWLLRGHRTPGAAKRVVDPERAFWDALERGDDPTLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0C5</accession>
    <name>A0A7W7T0C5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation-control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009776">
        <property type="entry name" value="Spore_0_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40053">
        <property type="entry name" value="PTHR40053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07070">
        <property type="entry name" value="Spo0M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="33704" checksum="CEDEF466D7541607" modified="2021-06-02" version="1">MFKRMLSAFGVGGPSVDTVLDTPHAVPGQAVSGQVRIQGGSAEARIDRIVLSLVTRVEVEHGDHEYGGNAEFLSVVVAEHVVVAPGQALAVPFRLPLPWETPITAIGGQPLPGVGVGVRTELVIAGAPDKGDLDLLLVGPLPAQDSVLDAFGRLGFQFRKTDVEVGRIHGVHQELGFYQELEFSPPGHHAGRVDEVELTFVTSPHELVVVLEADKRGGAFSSGGDAFGRFHVSHQDAPRTDWATLIDQWLTQVSQRASAFGGHPGQHGHHGYDHGHHGHHGSGVGGVVAGAAAGVVGGMIIGEVLDDAFEDGGEAFGFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0E3</accession>
    <name>A0A7W7T0E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="42113" checksum="5BC55CA99978059B" modified="2021-06-02" version="1">MTADWLARRAEIVAEGNDLLYRAEEMDLASDLSDDVWLVRRLPDPDDAVRWALLRDEYRDLLPDVTVARCPDTGAVVRWAIDTGGLDGWFWDSNYPVRRAPELPPTWLAMTGAVALRGEVAWVPFRCRPGPRVPYVVPRLLREDGVRAVIAQVPIGTHVGWAVSYFGPLPSTVDGIGIWGRMTMSPPLGGGGHEYFFFDVEDNDYDLGPWLESGKLLWIAPDDDTATLREGVAGCPYRGLEGSHLATLIDGYDVWDDSEDDPYVESRDVVHVEFDPGALTPEVLARLCEALDLEPLVDRPREENAVRGVTTGFELPPDTRLRLFRGTGEWRLEADCKGEFPAHEVVDAVRERLLGVLTAFGFGVVRSRVYGPDRMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L6</accession>
    <name>A0A7W7T0L6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="33753" checksum="0FE3E0080A0EEA15" modified="2021-06-02" version="1">MAAPTTTSDFADAVRDEDSLRRFLHGLPGVDQVGVEQRAAGLATRSIKKAAKLWAIDTAISMVDLTTLEGADTPGKVRSLAAKARRPDPERPDVPQVAAVCVYPDMAAVAVEELAGTGIGVASVATAFPSGRSTLKVKLEDTTYAVAAGATEIDMVIDRGAFLSGRYGQVFDEIVQVKHACGDAHLKVILETGELATYDNVRRASWLALLAGGDFIKTSTGKVSPAATLPVTHVMLQAVRDWHARTGQLRGVKPAGGIRTTKDAIKYLVAVNEVAGPEWLTPALFRFGASTLLNDLLMQRRTQLDGHYSGPDYVTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L7</accession>
    <name>A0A7W7T0L7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">F4559_001761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="312"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="198"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="563" mass="60524" checksum="B46E1CC6E94912AE" modified="2021-06-02" version="1">MVLQARTTKHVFVTGGVASSLGKGLTASSLGQLLTSRGLRVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDIGHYERFLARDLSGEANVTTGQVYSEVIAKERRGEYLGDTVQVIPHITDEIKRRIRAMAEPDADGNAPDVVITEVGGTVGDIESLPFLEAARQVRHDVGRDNVFFLHVSLVPYLAPSGELKTKPTQHSVAALRNIGIQPDAIVCRADREIPDALKRKIGLMCDVDTDAVVAAVDAPSIYDIPKVLHGEGLDAYVVRRLGLPFRDVDWTVWGDLLGRVHNPSEKVRVALVGKYVDLPDAYLSVTEALRAGGFAHRAKVEVVWVASDECDTPSGAAHALAGIDAVLVPGGFGVRGIEGKIGAVTHARTRGIPVLGLCLGLQCMVIEAARNLAGIADANSAEFEEVGSPVISTMADQQDVVSGQRDMGGTMRLGAYPAKLVPGSQVALAYGAVEVSERHRHRYEVNNAYRDRLAKSGLVFSGTSPDGRLVEFIELPADVHPFFVATQAHPELKSRPTRPHPLFAAFVKAALDYRLADRLPLPETAGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q8</accession>
    <name>A0A7W7T0Q8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10273" checksum="09EC919272DC268A" modified="2021-06-02" version="1">MAHDDEDTPDDFEGDFEDDFEAEDDFEDEEDTDVEDDLFGVTSDPRTICHLCGGAGFIANPTLAVIGGSPRSVDNGRECPHCLGARKFPGLVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R9</accession>
    <name>A0A7W7T0R9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">F4559_001525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12939" checksum="E2954490D83F0D0A" modified="2021-06-02" version="1">MTLDPSLSARLKRNADGLVCAVAQDRTTGRVLMVAWMDDEALHRTLTTRRATYYSRSRRQLWVKGETSGHTQYVHEVRLDCDGDTLLLTVDQTGGACHTGDDTCFDADVLLSPDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W9</accession>
    <name>A0A7W7T0W9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25737" checksum="A15C1346613D9939" modified="2021-06-02" version="1">MGQLVWDASQRRDHRSAHQYFDQAHAAARRVHDSTAAGLSLLRKSYVALYGQKNPKAGLALTTQAAETTARTSHVINALSTLHAAEAHAMMGEQAECEHALDQAGQRFELVSDDDVALDLFSPTQHGRLAGSCYLFLGEAGKAETILDTTAGRLRDRSKSEAIVLGNLTLARLRQGKVDEAAATLHRAMDVIERTWGGGGLTIMFDACREMRPWRTRTEVQDVHDRMLSLMATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T183</accession>
    <name>A0A7W7T183_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="20857" checksum="45A45A54161D3FAC" modified="2021-06-02" version="1">MSGGAPGRSLSVTSTKIVVAGGFGVGKTTFVGSVSEIVPLTTEAVMTEASVGVDDLSNTPNKMTTTVAMDFGRVSLDQDLILYLFGTPGQHRFWFMWDDLVRGAIGAVVLVDTRRLSDAFASIDFFEDRELPYVIGVNCFDGLLHHRIEDIREALTIDASIPIVPCDARNRQSTKQTLITLVEHALRQPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L4</accession>
    <name>A0A7W7T1L4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22109" checksum="AB74D421655FCA94" modified="2021-06-02" version="1">MEHTAAGEAAVLYRDYVDSVARAGGNPVLVPPAGVWDADAIAFLDALVFTGGPDLDPALYGRCRDARTGPSRPDRDAAELDLARAALKRDLPVLGVCRGMQLLNVVRGGTLRQHVEGHDPEHGHTGIAVAPGTRLSSIVGMATTVHCHHHQAVDVPGDGLRVVARAADGTVEAVELVGARFVVGVQSHPEADSEDDRLFAALVDAAAGSPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L8</accession>
    <name>A0A7W7T1L8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10712" checksum="6D9891FBCB01E1DF" modified="2021-06-02" version="1">MVITREGDPPGIVLSGAIDPDDLAELRALLLADGCGDVRLDLRAVPFLVVGTLRVLVQTAVELHESGRDLVLDLAPQHEWTIGAVGWSAAPGLVLANGTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M4</accession>
    <name>A0A7W7T1M4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="47" mass="5169" checksum="17634AAF43C6F5CA" modified="2021-06-02" version="1">MSDDQFRHDAAVYASDEEFLAMALPFVAAGSNSANPCWSPPPRPTWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V8</accession>
    <name>A0A7W7T1V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein/non-ribosomal peptide synthase protein (TIGR01720 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002378</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="471"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2458"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1090"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2545" mass="275616" checksum="5BAB4E7A694CFA88" modified="2021-06-02" version="1">MTHALDLPALVAERVRRTPGAPAIVSPDETVDYRELDARSNRLAHLLIDRGARRERVIALALPRSVEIVVAQLAVLKTGAAYLPVDPAYPAERIAFMLADAAPLLVVDGPLDTSAYPEHAPEVAIRPDDPAYVIYTSGSTGKPKGVVVTHRGLPAFARAEAEHLDVRPGDRVLQFSSPSFDASVLELCMALPTGAALVVPPPGPLLGEQLADVLEQQRVTHALIPPVALATVPHRPLPDFRTLVVGGDACAPDLVARWAPGRRMVNAYGPTESTVVTSWSGALEPGGTPPIGRPIPGTEVRVLDADLRPCAEGELYVTGVGLARGYLGRPGLTATRFVADPFGTPGARMYRTGDVVRVRDDGDLEFVGRADHQVKIRGFRVEPGEIEALLGTHEGVAQVVVVPRDEPKRLVAYVVGRTDGLREFLAERLPNYMVPAAFVALDRFPSSPNGKLDRSALPAPVVGDVPEGFVAPRTETERRVAAVFADVLGVTVPVGAHDDFFALGGDSIRAVRVLGRLGGLPVRTLFESRTVAALAEHVPDAPPAPIPAVSRDGVLPLSPAQRRLFSLDGTAEQNTAAGLRLTGRLDLDRLAAALDAVADRHDALRTTFDVVDGEPVQVVASTGTIPLNLTTEPEAALAEPFDLRTGPLTRALLVPLGVDDHVLVLNQHHIVTDGWSVGVLVEELADRYAGVAPPEPTVQYPDFAAWDAARPVDGLDHWVARLSGVEALDLPTDRPRPALRTTAGAVLRTPLPADLVDRLTGVGRAHDATLFMTLTAAVQVLLSARSHQRDIAVGTVASGRDRADLDRTVGFFVRTLVLRSWVDPELPFSAFLDDVRTTALDAFAHDRVPFERIVAALRTAPDPSRSPLVQAAVALHEPLVRRTSFGDLALSEYDLPRPNARFDLVVEFWPRGDDLTLTVEYNRDLFDEATIQGLSTDLRALLERVVEHPDRPLRDLAGLDFPPDDAVRVRGLRVDPDEVEEVLRRHDDVTDAAVVAVDGRLVAYVAPAANPAALRGFLEQVLPAHCVPTSYVGVAELDRSALPTPPAETAVRHVAPRTPVEAVLADVFAEVLGARRVGVRDNFLALGGDSILAIQVVTKARAAGLVLTSRDVFAHQTIAALAPHVTRDAPPVTHQGEVTGDAPLTPIQHWFLDRHTVRPGHFDQSLVVEFGHDVDPAALRTALNALVAHHDALRMRFTPHRQHNAPVTDVDLSGVKEFDLSTGPLLRAEVLDARRVRLAAHHLVVDGVSWRVLAEDLKTAYGQAASGKTIHIGRKTTSFRDWARRLHAHTAAGGFDDELAHWRSVRGDADLPVDRHGPDDTASERVVTVRLTAAETTALLRDVPPVYRTQVNDVLLAALGRVLADWTGRSRVLVDLEGHGREELFDDLDTSRTVGWFTTLFPVALDLPDADWGTTLKAVKEQLRAVPRKGIGYGALRHLAGADIAADPRVGFNYLGRFAAGQRDLDLSADPAAPRPHLLDVVGKVQDDRLEFSFHYSDNAHAEATIRVLVEGFADALRGIADHCASPGAGGRTPSDFPLVALTQEQVDRITGEDAYPLTPMQAGMVFHGLARQGLYFQQTSFVVDGVPDSAAFARAWQDVVDRTPVLRSSVLWDDVPQPLQVVHAHARVPFTFLDWSGMGDRERAERWERLLADDRDQGLDLGVAPLMRVAIIRLSPDSVRVLWTFHHVLLDGWSVFHVLSDVLAPDLALERPPFRDYVAWLDRQDDRAAERYWRDVLGTFDSPTPLPLDRQGDLHAASSAHRHGIELDEAESARLYEFARRHRVTPSAIVQGAWALLLGRSSGRRDVCFGATVSGRPADLPGVDAITGIFINTLPVRVGIDGTAPVAEWLRALQAAQVEARAFEHVPLTRLSGWSGVEGGTNLFDSVVVFENYPTDLSDGMGLRELQAVETTSFPLSATVYPENRLGVVLGYEPDLFDAATVRVLGERLRTLLGGLVADPDRPLSRVPWTTEVERARIADWTGRGGEFATGTITARFAGQAARTPDAVAVTCQGSSLTYAELDARANRLAHHLIARGAGPESLVALRFPRSLDLVVAVLGVLKSGAAYLPVDPDYPAERIAVMVADARPVVVLDALPDLAELPATAPEVVLRPEHAAYVIYTSGSTGKPKGVVVPHGNVIRLFTATDARFGFGPDDVWTLFHSYAFDFSVWELWGPLLHGGRLVVVPFEISRSPADFAALVRDEGVTVLNQTPSAFYQLLGERIAVRYVIFGGEALDVRKLASWQGTGELVNMYGITETTVHVTHTTADGTIGVPIADLRVHVLDEDLDPVPPGVVGEMYVAGAGLARGYLDRPGLTASRFVADPFAADGSRMYRTGDLAKWDSGRLRYFGRSDHQVKVRGFRIELGEVEAAMHAHPSLADVVVLVHEHRLVAYYVPEHHVTVSELRDHATGVLPDHMVPAAFVALEALPLNANGKLDRVALPAPERDAVTSAEYVAPRTETEQAIADIWAEVLDVDRVGVEDSFFALGGDSIRSLRITARTKAMFDVDLSPRDVLTARTVTGLADLVEELVLADLEALADREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V9</accession>
    <name>A0A7W7T1V9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein/non-ribosomal peptide synthase protein (TIGR01720 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010060">
        <property type="entry name" value="NRPS_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01720">
        <property type="entry name" value="NRPS-para261"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="941"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2325"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="3305"/>
            <end position="3379"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="4687"/>
            <end position="4760"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="5668"/>
            <end position="5742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1351"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2361"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="3340"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="4722"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="5703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="6155" mass="665484" checksum="17FB5CF9E373F393" modified="2021-06-02" version="1">[encoded data, 6155 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T206</accession>
    <name>A0A7W7T206_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ORF">F4559_001244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="140"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="38540" checksum="F0DF587224E6F240" modified="2021-06-02" version="1">MTERKTKVAVVFGGRSTEHTVSCLSAGSVLPHLDRTRFEVVPVGISPEGMWVIGADDTKALEQRDRELPSVKSLVPASGGALTPVQPGVALADVDVVFPLLHGAWGEDGTIQGLLELADLPYVGPGVLASAVSMDKEFTKRLLRGAGLEVGRFVVLRRDQETLTSEQRDELGLPVFVKPARAGSSVGISKVVDWAHLDSAIALARKTDPKVIIEAATVGREVECGVLEFPDGRVEASLPAELRIVGGTVDWYDFDAKYLDDVCEFDIPARLDPDVTARLREQAVEAFRALDCQGLARVDFFVTEYDELVLNEVNTMPGFTPISMYPRMWAHTGVEFKELLTILIETAAARGTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T250</accession>
    <name>A0A7W7T250_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29370" checksum="3AF44CC35E04E3E6" modified="2021-06-02" version="1">MVTKLRARLHPFDLLPLVVPLLYAVLLGGLVGVAPGLTDQTIHKIYTSAFEIDQVDIDCVSAGTLRVCDTEVAGRTLHIEVDTEIVLVGPCHASYAGEQLACAKQSQYGQSSPTVIVTGLLGFLSEDDIAAMRDRVPWWHPLVEDWESALLPVPLALAALVFLIALFEPSHGGRRLLPPAGLVAVVAIGVWFVTAAIAVFAVPADRPNPVAWVPMLAVHVGSIVAATYLAWAFAEFGPRPGVLNRIWYVAVITLTTGFLASAGLLYVAVFSGFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T259</accession>
    <name>A0A7W7T259_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protocatechuate 3,4-dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="5">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="29005" checksum="E3B951A177C3F02E" modified="2021-06-02" version="1">MHDDDEPVGRVLGRRQALALLGLAGTATLAGVGIATASAGAPDCVVVPEQMEGPYFVDEGLKRSDLRLEPSTGLLCEGTLFTLDLVVSRLEGKDCVPLQGAIVDLWHADAKGKYSDIASEGTQGTKFLRGLQVTDRAGRVRFVTILPGWYKGRTVHYHVKIRTTGATNIPYEFTSQLYLPETFTAQYLATGPYKPNGPQDTTNAADVIYQAGGDQLLLNPRRVGRGHRATFGIALDLTDKVTGNDDNAMTGPFPPGMPSMMPGTFPTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A7</accession>
    <name>A0A7W7T2A7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="35047" checksum="F00E3C7FE6DEBE68" modified="2021-06-02" version="1">MTDPTPLVNVATGFMAAKQLFAASELGVFAALAAGPATSAELAERAGLPERTARILADAMVGLELLAFADGKYTNTAVTAEYLSGGDGLDLRPWLGFWNGMSYPHWLHYTESMRTAQPGPFQLDESNMGEFMNGVQTYNSLHAQQLAEHYDWRLHKNVLDLGGLAISFLTEAAARNPELTGAFVTTPDFIKMLEGSLTGELADRIKFQAADPLTDEIPGHYDAVLLEHVLHRFTPEQNKTFFTAARKVVDPGARLLVVDFLLLADDARRIDPILAGEYLVIDGTVVYPEAEVVSWLGETGWKFLETRPIPGSPRVVIAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K5</accession>
    <name>A0A7W7T2K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15371" checksum="AD6BFEB9465B3417" modified="2021-06-02" version="1">MTDVFASTVFFRLSVAGNDLGAFHTCQGLGAQFEVEQYAEGGNNGFTWQLPSRITWSPVTMTRPVTADSAKVLKWFGEVERRAERKDGEIVALAPDLTPIVRWQVLGVLPLRWQGPSFDPSGSQAAVETLEFSHEGLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L6</accession>
    <name>A0A7W7T2L6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030946969" evidence="2">
        <location>
            <begin position="33"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20677" checksum="75DE2BB5F6914C57" modified="2021-06-02" version="1">MRFKIRIMIAAGLVASLAACANTTTPGTPTPAETGGGSTKGSPTTGAQPSTGDDVDIAKFADKPCDLVKSDQLALLGRVRETKPGTNTLGPMCTWKGTDPTKDNTYELSLVNKGPTFDSMSENFRDYPIFRETTIAGLKAVSVDRTNGTSSCETLVRTSAKNAVFIQTVLPATGKGTVEQSCQASEKVAAIVIGNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R8</accession>
    <name>A0A7W7T2R8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001592</name>
        <name evidence="4" type="ORF">F4559_002858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="109"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="36029" checksum="E40EF6AE38A55243" modified="2021-06-02" version="1">MKKSCTLTGTSRATHYRHANPTGPMHGPRPARTPPPQALDADERARVLEVLTSPAYRDLAIPQVWARELDEGRYWCSISTMYRIARAQGQVRERRRIATHPPRTRPELSARGPGEVWSWDITALKGPVKGVWYKCYVVLDIFSRYVTGWLVAAAEDAVLAKDFLAEAIARNGTEPHTIHADRGGAMVSKPVSELLTDLGVLRSHSRPRTSNDNPYSEAQFKTLKYMPDFPDRFGSLADARLFCEGFFLAYNHEHRHSGIGMHTPASVHFGTAGRIRDQRQATLDRAHARHPERFARRPRPPALPEVAWINQPLDQPQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X7</accession>
    <name>A0A7W7T2X7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21409" checksum="49DAC4300C1697C7" modified="2021-06-02" version="1">MKVTATSVGDQGRGSDRDAADEIAAAWQRERPGTPTESIGVVTRLWRLAKVFGEDRRRVLAASGVDSATLDLLSVLRRSSPPYSLTTRELTRLTLVTAGAISQRVARAERDGLVRRWSDPGDRSVWVQLTPDGHALVESTVDRVLNRELELLAGLDADQRDRLADLLRLLLRDVQERLGDHGISHVGDADGIGSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z8</accession>
    <name>A0A7W7T2Z8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027573">
        <property type="entry name" value="Methyltran_FxLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04364">
        <property type="entry name" value="methyltran_FxLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="44339" checksum="964200CCC9DD43DC" modified="2021-06-02" version="1">MDTATSPEARRADMVAKVRKAGYARRAEVERVLLDTPRHEFVPEADLDAAYNPWQAVITHRFSDGRSLSCASAPFVVAMMLDQLPVNPGDTVLEIGAGTGYNASLLARLTGRADLVTTIDIDPDVTDQAVRNLTAAGHGDAHVVTGDGTAGHADRAPYDRLIATVSPWDIPDRWWRQLAPEARLVAPLRWRGQSRGVGLRHVDGRLVSDSMHLSGFVYLVTEDEGERGAPITPDGTVKLHWDADQAVDPDLLHGVLDLPRAIAWSDSTIAGDEPHDGIWLRLTVTEPRVCRIDAHPDVASEVCDPIQRFRAPALVDGQSLAYLTSRRREEGDDVRWELGAIAHGPDAAELAGRLCAEVRDWSAERDARKPTLLIYPAGTPDGDLADGTVIDKTHSRFVLTYDYVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T304</accession>
    <name>A0A7W7T304_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21004" checksum="FAE2218C4B8D1ABD" modified="2021-06-02" version="1">MNPRHLAVASAGPGRFALVDATDLPYPDESFDAAWALQSVVQIVDQAAALREVRRVLVPGGRFGVGDIVTHDRLPERYAASWTGTGAHTPDSLAALVEDAGFQVLEATDVTRETRCMVSWHVDELFRRLDGLTPRAADECRERYFDEISARHGTAAARLLAAVADYRAHPDYARDEAAMGFVVVVARKGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T325</accession>
    <name>A0A7W7T325_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002975</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="255"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="49030" checksum="B95A7209981C9661" modified="2021-06-02" version="1">MTRLGLRGVVVLTVVLVTVVTTVAMATTAYLIQAGATRTRFAESAQASFDSDAQQAHQFLVRSTEFRSVVAGVAEYMRARLGLTWTIVNRTSTSGPLSVKSDGTYLPVAGSGDPLAESLVDDLESGSVRYEEDSRLVIVGEVEPGVVLAEFYSTRGLDRELAALRGVLALVAVAIVVLGSVSGLFAARGIRRRVRTAALAARRLGDGELDTRLPVDGRDELADLAGSFNAMAERLGESIERLRLKDRQQRRFVADVAHDLRTPLASLIAAADGLHSDDEADRTRSAELLGSQTRRLGALVEDLLEISRFDAGAAEFRPEVVDLEALVADAVELSAPDVEVRTERVGDVAVFGDPRRLHTVVRNLVTNAVRHGGPPITVTIDGGDPDEVRVRVADKGPGLGDLAPVAFDRFVRGDRSRRHTEGSGLGLAIARENALLHGGRLEVHDEDGAVFTLTVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T410</accession>
    <name>A0A7W7T410_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="25637" checksum="336743A068F0D362" modified="2021-06-02" version="1">MTGYDALVARDDVDAVYIPLPPAPHHRWIVEALRAGKHVLAEKPLCVDPAGTTEVVAPARRQGLVFAENFLFPHHSQHRKVEDLVRNGTVGDVRAFSSAFGIPAVDPSSFRHRADLGGGALLDAGVHPLRVARFLLGTTTTQETATVNGVPQLIRPGTYWDKARRARLLADRGAGLVLDRDACTADDVRRSPARLLDEPSFVADAARLRDESREVPSPDEIVPLLEELTAKAAANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T421</accession>
    <name>A0A7W7T421_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9288" checksum="1D8BF1781B8EDE19" modified="2021-06-02" version="1">MPTSPESDPLTVPASREQPTLFVPIVGVLPEVAPALVRPYFTAAERARRFRDTTSGTHTRDGGPPTGGATPTTGKENGSKWKHSTMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4C0</accession>
    <name>A0A7W7T4C0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="7750" checksum="40D54015E870BAF3" modified="2021-06-02" version="1">MPARLVVADPDLAVLDEPAADESLDVALAAAIEGRDRRPPGSARPAAAGRIAEVGRRVRGPVAWVGGRATAILDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N8</accession>
    <name>A0A7W7T4N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="27939" checksum="8419DB3C0C80777B" modified="2021-06-02" version="1">MLLVPIALLYWWQWHTHRKDEREHAEALAAFADEVGGKVVGRDEARAWSADLLSPLRHQTEGFFNKLGTRRRARFDTAIDFRRDGWPVRVSEASIRKSVPTAGTTTIYEYRIEVAVDSVLPPMRISQLVHADFRGRPLPPTPSGYATEPPSGAPQWLPARLPAEVEQDFAAYTTDPVAVARAFTPQVVEWMVGRTDEPSFLSTMPFLLHFEGGLVFATIGKRIDTETLLPRVDAIIGLISRLGDRPALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T9</accession>
    <name>A0A7W7T4T9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF853 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="369"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="971" mass="102819" checksum="BC621D79BC8DC1C0" modified="2021-06-02" version="1">MSLFDGMRLVALRSTPRYADQALVTALTAAHPELLAAGGVLLGLWQRLPGDPRVHVYFGGRPAFPAARPDDRLLYPPGATAAPADPPAMPFTTWVRCTVRTDVPVDPVGGFDEHVAHSGDPFSWLTVARPLTAAAVADELADLDMRIPPLRRDVRLESSRTALRHAEHRYQELTIAQVTGAWAVEVFVAGPTPLDARRTAAALCASADLPYRLIPDGSAPPTGPTTTAPGLAPSGPFLAGHDRTGPTATGPIATGPAVTRPVETGPAVTRPVETGPAVGDSAAAGPLMTDSAAPGPVAGEPVVSGAGVGGPPVSGALVAGLIRPPRRELPGVRLVDHADFDLTPETSGDLVLGDVLDDTDRPVGTFSFPTATLNRHAFVAGATGAGKSQTIRHLLERLHHAGIPWLVVEPAKAEYAAMAGRIGAVTVIRPGDPDAVPVGLNPLEPEPGFPLQTHLDQVRALFLAAFDAHEPFPQVLSHALFRAHTDLGWDPVTGTSRLPGVTPRRPTLADLRRAALEVVRDIGYGREVTDNVRGFVDVRLSALSLGTCGRFLDGGHPLDVADLLARPVVLELEDVGDDQDKAFFIGAVLLRLHQHLRTRRGTGSGLRHVTVVEEAHRLLRRAEPGSPGAHAVELFTALLAEIRAYGEGVVVAEQIPAKIVPDVVKNTALKIVHRLPAADDRAAVGATMNLDEAQSRHVVSLPPGRAVVFADGMDRPVRVAVPLGEDRERTGRGPDVALRSRRTAACGPLCAARPCLSREVNAAGLLAGEPRVVLWIELLTIAHLVGRPAPRPWRSWLASLRGDRRTVECAVAHRVGHAVDVRYRGLAAHYRPESLAAHLTASALSTVDSRSTGCDGTEVTWQAGRHRWADVAAALRTFEGDGPHPDTAAWSARGLTLTGRNAAEQAAELRDHPDSWQPDESVVTGDRAYAAAVDRLSRATPLRARFLAATAFLDLGTTWPLAVLPDPGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X9</accession>
    <name>A0A7W7T4X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1058" mass="111948" checksum="C4E8A26E74A7032B" modified="2021-06-02" version="1">MRVGVLGPLQVTDGDVPVAIGGARLRVLLVRLAMAPGRVVTVEEIVDALWPDGTAQPADAVSAVRSLVSRLRRALPDAGALGSAAAGYRLDVPADDVDSHRFDRLAREARRALGSGDADGARVRLAEALDLWRGPALADAATLPFATGYVAGLDEARLGAVEDLAEADLLSGRTDHLVAGLTDLAARHPLRERTRALLLRTLAAVGRPAEALAAYEDARRALADELGADPGPDLREAYLEVLRAEPARRPRTGGVRAPLTSLVGREREVVAIGEDLAAHRLVTLVGPGGAGKTRLATEIAAKAPSVWLVELASVTDAADLVPAVLGVLALREPTRTVDIPLPSADPLARAVEVLSHAGALLVLDNCEHLLDASARFAAELLGRCPRLRVLCTSREPLGVTGEAVRPVPPLDVAGPDAPVDALSSGAAVVLFAERAAAVRSGFAVTPDNAAVVAEVCRRLDGLPLAIELAAARLRALSVEQLAERLDDRFRLLTGGSRTALPRHRTLHAVVAWSWDLLDDDERDFAERLAVYAGGVEADTAEALVGDRALDLLTALVDKSLLQVVEAPRPRYRMLETIREYGLERLAETGRVAAAHAAHAAFFRDLAESAEPHLRTADQVRWINRLDAERDNLLAALHFTTAGGDVDTTIRLSAALGLFWTMRGSSPDAIGWLRLALGLPGGPRPQRLAVEAFLLLNLIIAGGFEELAAHTASLRVVAEGAVDYPDHPFLPLVGPLIGLITDDYLAANEALAPAEGHPDPWTRAMLDTFRCGLLENIGDMAGAREVAERAIDGFRVVGDRFGLAQLLTEVAPVYQAFGEVDRAVAALEEAVRLRRELDPDDDLPFERMMLAATRAVAGDVDRARAECRASSLPAFEGPTAYAPVVMATLTLGNLARYEGDLAEAGREYRRAADASARTPHVPQFSALVAVGFAHLAAAKGDLETAGEQARTAVAHALAAKDMPVLARSAVAVARLRLLSGDAAGAARVLGVAARLRGAPDPRDPDVIAVADLSRADIGDAAYDLAYAAGLALDREDAVKLVDEDRASGRSNPPVKWGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z3</accession>
    <name>A0A7W7T4Z3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="33009" checksum="8629947D3E9725FB" modified="2021-06-02" version="1">MAIIEVVDLVKRYGAKTAVDGVSFTVDEGEIFGILGPNGAGKTTTVECVGGLRAADSGTIRVAGLDPRRDRVEVRRLLGAQLQESRLPERIRVGEALALYASFYPDPVDWHALLDRLGLADRVDVEYRKLSGGQKQRVSIALALVGGPRVAVLDELTTGLDPAARRETWDLVERVRASGVTVLLVTHFMEEAERLCDRIAVIDQGRVVAVDTPAGLVSRVDARQRVRFRPVGAFDADLLRALPEVTDVEEHGGRVVVTGTGELLHAVTSLLARNQVVAAELRVDQPGLDDAFLHLTGRAFSEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T506</accession>
    <name>A0A7W7T506_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031089193" description="SGNH_hydro domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="37"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35300" checksum="4ED242838ED6AC5F" modified="2021-06-02" version="1">MRVRTRIGTLIAALPMVAATLATPATAAPRADFKWVALGDAYTAGLIDATGPEVIEGTGRDGCGRTAGSYPEVLRPRFADRFELVNVSCAGATVANVMSEWQEPQGRNLPFFGVFDPDHPFGAVPPQIEAVTEDVDLVTVGVGGNTLGFIEFMYACVVIGQWAAPNEDAPCSQHFTTGWDGVPTVDDRLSALGEEYGEMLRTIRAMAPTATVIAVGYPAIIPLDPRGCDHGLTPEGIRDFATVTYPDLAWLRTDVLQRLNQLIADQAALNGSLYVDVQAITEGHDVCQPESRRWVEGIADSVGRWSLVRPNAAAHAAVADVIEALLLAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H4</accession>
    <name>A0A7W7T5H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="27895" checksum="EFBCDBBF3B90B1D0" modified="2021-06-02" version="1">MMAEARELGPIYRMRIFNSEFALVTGADLVAELADGTRFRKNVHAELVMLRDLAGDGLFTAFNDEPTWRKAHDVLLPSFSLGAMRGYHPTMLRVARDLLRKWDDATGPVDVAADLTRLTFDTIGLCGFDFGSFRDPEPHPFVKALAGALAYARHKSESLPGMEFLRRDRARRYREGDEVRARVHVCGDGRRLAPGVKAAFAALYEAKTGGDGGSRVAGMIASGRYAEDVRQGGRAGSCPVRAAASATSPAVTSAMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5N2</accession>
    <name>A0A7W7T5N2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="538" mass="57454" checksum="712F665DC15464D8" modified="2021-06-02" version="1">MEFLAGSPAPTPVAAALLIAATLFLTCVDFTAPGRTRYVGVLVAIPALAFRDELRGLPPGVLVALGLVLGLARLSPVGLVIAVAAASDPVSTAGFVVPLAVGWFLRETVSGRRSPAAWVNRAFGYVGCALGLLPLVLVFAVPLPDASGWQWVARVLGALLMGKLLFDHEVDRWGVLRGRRHGLRAVEIGLVLMGFAVAAGPIGARVVEWWGITTWGLVPLVYFLAAYAAHRVVRKLRVRFLELCTTCASAAIRGALWLPFLLVGLTQPAHFGLGSAVLYLFVGVVVSPLERHELRSKRHLADLKRLLRADEAEREAALGRWAEDMVGRPYFFTYHLPNLAAGVAIGASAGAHPQFAPEEVPGLLAIARDALDAIGRATPPSYQTRGEQFGARGDHARHVAHVCENLGQTQGRLDAAEEAAEWYGELEVPAATTVALVEAAAAALDLDRPDHAADLLDRVPSDLPPPVDRYVTVFRAHLAARGGDLDEARRLVGLLPAYDAKALIRALAAERLPYGPDLSELLPRIVESEVGLRQLGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5W7</accession>
    <name>A0A7W7T5W7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004522</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="250"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="463" mass="48287" checksum="3C5F7622B02C6B45" modified="2021-06-02" version="1">MVGLLAAICVVIGVVASFALRDFMVSKLDEELVRTADRAAGFTGMPRPDGDSSLKPLDFPGFGPGTLLLTFRDGAADSAGRLRPGSGNREELPGDQQRLLDSVPTDGLPRTVDLGTLGAYRVIGVANHRGDKVVAGLPMATVDANTVQLGLILGGVGLAGLIAIGLVGVSVIRRALRPLERVADTATRVAELPLHEGEVALAERVSEQDSNPATEVGRVGLALNRMLGHVGNALAARHASETRVRQFVADASHELRTPLAAIRGYAELTRRANADVPPEIGYAMGRVESEAVRMTSLVEDLLLLARLDAGRPLEFGPVDLTALVVDTVNDARIAGGDHDWKLELPPEPVTVSGDRDRLHQVLANLLSNARVHTPHGTTVTTSLSVGDGGATELTVVDDGPGVPAGLQPEVFERFARGDGSRSRAAGSTGLGLSIVSAVVTAHGGTVALTSHPGHTRFAVRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T617</accession>
    <name>A0A7W7T617_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="949"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1085" mass="114173" checksum="C347ED6841566918" modified="2021-06-02" version="1">MHVADEDGPRPAPVDDHEPIAVLGTACRFPGGVRAPGDLLRLAVDGVDAVSDFPANRGWPDLHDPDPEAVGRTYVRHGGFLHDADQFDPGFFGMSPREALATDPQQRLLLETSWEALEHARLLPETLRGTRTGVFTGVMYGDYGSRARLPLDGVEGYLFAGSSGGMAAGRVAYTFGFEGPALTVDTACSSSLVAVHLAMGALRRGECDWALAGGVTVMATPAPFTGFSRQRGLAPDGRCKPFSADADGTCWSEGAGLVLLARLSDARRRGHRVLAVLRGSAVNSDGASNGLTAPRGPAQERLIRSALADARLDAADVDYVEAHGTGTPLGDLVEARALQATYGRAGTVLVGSVKSNIGHTQAAAGVAGLIKVVEAVRAGVLPRTLRTTPLAPHVDWDAGGVTPLTADRVWPETGRPRRAGVSSFGYGGTNAHVVVEQAEEPRRGAIPPQTSRSPDPARARADRWTPLTDAFAAWVGVPRAECEPGPAVPCASKEEQGGWSHEPVVPWVFSGKTADAVRAQAKAAADVEGSAVDVAWSLATTRTAFGRRAVVVGAGRGELARGLGDLVVEEAAPGRVAFLFTGGGAQRVGMARELRAFPAFARAFDEVCDAFDGHLARPLRDALDGEVHRIDFTLAALFAFEVAVVRLFESWGVRPDLVVGHSIGEFAAGHVAGIFPLADAVRMVAARGRLMHAVSAGGAMLAVEATEDEVVPTLRGRVAVAAVNGPRSVVVSGDEDAVVAVGVLWAKRGRATKRLAVSCASHSPHMDSVVEGLRPVAARTAFQPPRVTMVSTVTGRPDAPVATAEYWAVQVRRPVRFLDAVRTAERLGATTMVEVGPDGVLTALAAAGVDRAVPIAAVRSGGDERRSVVTALGRLHARGVPVDWPAFFAGSGARVVDLPTYPFQRRRFWLESAGADPVTTAVEVPVVADREPVSLADRLGDLGPTERRAVTLEVVRAQAATVLGFGDPGAVEEHRSFRELGFDSLTSVELRNRLSALCGSRLPATAVFDHPTPAALTDHLLGAVLPSRVAAELDRLERVIGDVSEADAAEIANRLRTLLARLPAARGDVAMFDLFDHARGWSCPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T627</accession>
    <name>A0A7W7T627_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NBD/HSP70 family sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="401" mass="41643" checksum="939ED3C668480A1B" modified="2021-06-02" version="1">MSAGNAATGPHVLRRINALAVLNALRAVDDLIATVSGLVQATGLSRPAVTRALTALTEAGLVEFTGATEHQVGRPASRARFRAELGHVAGIDIGPHKVLVMVADLSGKVLSQRQAATPADATGERLVRLLRTTLAKAAAETGVAPADLWSVAVGAPGIVDHASGEIVLAPSIAGWSGLPVTAELRGWLGCPVHIENDVNLAVRAERWRGESSDNLLFVQWGERIGTGMVIDDKPYGGASAAAGELGFIDLVTDLDAEPPAATDGLGAFERLVGAGAILRLAIQRCSGDVRDRLEATGDIAFLFDAAREGDEAALSVVDTIAARFARGLAVQLLLMDPQRVVVGGGVTRAGELLFEAVRKRLRPLLLAPVELRVSALGAAGVALGAVRMALDHVEERLTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B1</accession>
    <name>A0A7W7T6B1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="30" mass="3443" checksum="4F242B7D2005B6BE" modified="2021-06-02" version="1">MPPLAREDSVPRGVYVYVVPPRVDIRFRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J2</accession>
    <name>A0A7W7T6J2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrite reductase/ring-hydroxylating ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="28078" checksum="F2635176E6CA8AB3" modified="2021-06-02" version="1">MGLVGEVSSVAEVRLGQGRLLRQGLSKIGVFRDHEDRLHAASARCTHPGGLVRFNDTERGRDCPCHGARFDVGGAVLEHPVTARPGRLNPTSTHDDDTSTRTSPRRIVGERGNRKVMTEKNPDTPAQLSKRTWWGVLKRTVKEFNDDNLTDWAAALTYYAVLSLFPGLLLLTSLLGLLGPDATKSLVDSLNVLGPGEAKNLIVGAIENLQSSKALAGPLAVIGVVSALWSASGYLGAFMRAANSIYDTEEGRPFWKVIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S6</accession>
    <name>A0A7W7T6S6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-mercaptopyruvate sulfurtransferase SseA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9522" checksum="9DDF159E41F4D930" modified="2021-06-02" version="1">MSADHPVVAYDGGDGSVGARVWWLLRWAGHDEVAVLDGGYAAWTRENRPVSTDEPSPGPGDVIVTPGAMPWWMPLVPPDSPASGRTAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T747</accession>
    <name>A0A7W7T747_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12436" checksum="7497349246B3FA59" modified="2021-06-02" version="1">MRNIPVVLAGWRLRVTEDPELKTYEKDGVQEVATDQDGTSLFVVSLFAKPLPVEGRKAGKGEEIRVTLMMDPGSIGEGDLVELIDATVSPYSFKNDKGETVSGISFRAVGLKPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T776</accession>
    <name>A0A7W7T776_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protocatechuate 3,4-dioxygenase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="SSF49482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTRADIOL_DIOXYGENAS" evidence="4">
        <location>
            <begin position="62"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23848" checksum="AD836FC5E5C89DCD" modified="2021-06-02" version="1">MTEKHEDGTTRRSFMATGATAVAVTAAGVGIAGVAGSGQRAQGATLPLTPQCTDGDDTPPVIEGPYFRRNSPKRTNLRTTGVSGVLLSLTGFVYNIRCQPLGNVLLDFWQADQRGQYDNSTAQYRGRGHQFTNADGSYTLETIVPKDYPGRTPHIHVKVQAPNGPILTTQLYFPGDTKAYGMNVAQLNARDAYYITDTLIALGPLTSNRYAGKFDFVIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K7</accession>
    <name>A0A7W7T7K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10577" checksum="3ACE858A4D5ECE0D" modified="2021-06-02" version="1">MSEGYEVLVEELRGHADRLRGIKDTLDQALDAAGQVGLSGAAYGKICMMLPPMMTLIGSAGVSSIAECANAVDATVTGVRVTATDYEGVEQANRAVFRGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7M7</accession>
    <name>A0A7W7T7M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6538" checksum="8D4A38B5DADEFC2B" modified="2021-06-02" version="1">MSLVVDRAVDEMDAAMVTLRASLRGVPVDTPGFSASYEKARKAVGELLVGLTDVKSKVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z7</accession>
    <name>A0A7W7T7Z7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17716" checksum="2C17E50AEA0526BB" modified="2021-06-02" version="1">MTDPVFGTDEVRTEQEIARWAEGVAKKAERYQDLNRRVADVTIREVSRDGLVRLTVDATGALRELEISDKSREVGGASLAASIMATMRRAQSRISGAVAEAVAEAGIVEPGTAQALVSSYERRFPEPKADVPPWADQVRPSAPPPSRRTAPDDEDWDGPSVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D3</accession>
    <name>A0A7W7T8D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="110" mass="10858" checksum="D2FBDB38C5477905" modified="2021-06-02" version="1">MSDLAAEDQKLITLARASRARTGTAEGAAVRDTDGRTYAATTVALPSLKLTALQAAVAAAVSSGAEGLEAAAVVTDADALDGDSVSAAHDLTPGIPVLRADASGTHVDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8H0</accession>
    <name>A0A7W7T8H0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (TIGR02680 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013496">
        <property type="entry name" value="CHP02680"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02680">
        <property type="entry name" value="TIGR02680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1330" mass="143046" checksum="CCBA8F80F41D9EBD" modified="2021-06-02" version="1">MNRWRLHRGGIVNIWQYGEQVFDFSGGRAIFQGTNGSGKSRTLELLLPLCLDGDLRQVGSKGFDTVSVRRLMLDDHGGASTNRIGYAWVELTRGTDEYLTCGIGVKASKTSQAITDSWRFVTSERIGHDFFLVAEQTPLGPAQLRDLLGADRVLDEAAFREKVAEVVYGVPVARYGDLLHLQRTLRNPDVGLKVLEGQLEQILSDALPPLDPALVERLATSFDDLESIRENIARLSSADTALSTFLETYSSYAFGGLRTAADRSDAAEAAVRDLEKAARDQRNSLAHKEAEAASAEREQERLEAEERQAEESADALKQLPAFTRLQDLRTHERLVAEKRSSAVAALEAANRQRGAEDVAVDGVARALGRLADDLTSAHGSAVSLGEELVRIGLDPTPVTVPVLSTVDFSVREEEVRAKPDAGAPPLTVRRSVPPEVDVPDLAGPGERVAGIAAAARGHAALATALGERAGRVDEDDRRASSAERSASEAQDAAVDAAAERDRAQEDYVEAGRAWSTAVGTWLTTGPEVLDAAVPDAVDLDAARTVTAGARDRARPFTAKAGAEAHACAARCADLRAAVDAADADLAALRSGTERTPERTRFMSADRDPSSGAPFYRLVDFRPEVAESDRAGVEAALEACGLLDAWVTGTPDHACDVLAVPGPPVESSLAALLVPAVEPGSPVDEAVVAALLASVSIDSGTTAVSTSGRWSAGVLTGAWRKDAAEFLGAGARESARERRIAELEATLGQLRLDLGAAERDDAAARAAVVAWERHLDRFPADRDLAAGHALADSARRAAADRERRAADARAKARTLRAHAEATRADLERDAGDAGLPAGAESLRQAGHRATGVAADADRLADLLRHRCATAIGDLAEAAERHRVAVADRAEAEATADRRCADYASSAATVAELVEAVGGEAQEINDQLAKLDTRRRELRAALETERKRGVTTAAQVGRLSESVENTDRRLAAARADRDRAAAHFTDTIHAPGVLIAALPDVEADPAAVREALKTGRRAADEPKVLAKLQELQSTLAGTHEIGTGRHADLLTVTVTGEEGHRPVAVAAQRVTTLLARQRGFLDEQYQRIFADYLIRDLAEWLRGQIAVAEDLCARMNEILGRAKSSQGVHVKLAWKPSAKLDDATREGLALVRTPYAGRDQDQDATLRRVFTERIEAERDRHAGDYADILSSALDYRTWHQFTVTVADTGPDGKPRERRLRQLSSGETRLISYVTLFAAAASFYDAVGEEASPLRLVLLDEAFERLDDPTIARMLGLLVDLDMDWLITWPSGWGVSDRIPRMHIYDILRPKSGRGVACTKTTWDGAALDRVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9G1</accession>
    <name>A0A7W7T9G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041617">
        <property type="entry name" value="TPR_MalT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17874">
        <property type="entry name" value="TPR_MalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="759"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="799"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1081" mass="116940" checksum="FF6859F15BDFF95B" modified="2021-06-02" version="1">MGPRAEFRFLGPLQVLVNGQQVVVRAGRQRSLLVSLLIRAGSSVSVDELAEHIWGAEPPARARGTLQTYVMRLRQVLGPEIPIRTVPDGYLIDVDERTIDVMRFEQLVEEGERERAAGRLDAASSIFSAALDLWRGPAMVDVPSEVLHRDEVPRLGERRLHVEERLVEVELELGRHAGLVPRLSRLTSDHPLRERLWSQLMIALYRSGRQADALGAYRRVSGLLADQLGIDPGDELRRVHQQVLDGASALDLGGSGTAERRDRVVPSQLPADIGDFVGREQAVALIEALLRTAQGVPVVTLAGPPGVGKTALAVHAAHKMRQYFPDGQLYVNLRGYAQVQPLSAVDVLPRFLRAQGVAPELVPLDQDEQEAMFRSRLTGQRVLLVLDNAADAEQIRPLLPGSPGCAVLVTSRDTLRGLAVSHAASNVRLDVLDLDETRALLAGMLGEDVVAAQADAADELARLCAHLPLALRIAAANLLSRPEITIASYVDELRAGNRLAALAVEGDERAAVHAAFDLSYTALKPELAQLFRLLSLAPGDITPDVAAALGGLTTQDARRRLDRLATANLVDNHSPGRYQFHDLLRDYAAERLAVEGGPGEGTSAFHRLLDWSIRSVDNATDAMKATLMRLPRNDVVAGVTPRVFSTPAEALAWLDAERATLVATVEHGAETRPHGDIWQLADALRRYFYAQGLPAEWLATAKSGLAVAQAIGDPVGEVAMLSSLGTLHWGIGQTRVAVDHFRRAIPIQRRTGAAPAAEAAVLANLGGVYIDLGELEQAADYLERALVIVRGIGALQQEGIALVNLGGVYLQLGQLDRAVSSFEGALDVGNRLGVWITQADSLRSLAEVHLFQGRPSKAAELYERAGRLYERAGARGFAHIPHEGLAHTYVMRGHYEAAIESAARALGMAEEFENLKGVCDSQNALGEALLGAGRHEESVARHTEALRIAEETGYSWGICTARKGLARTHRAAGRLDEARYSAHQALDSAVKYRLRLAEADVLALLGRILLDRGEVAQALEYGKRAWKLSRATGQRYVEAKAAHLSGDAQVRLSDHASAAASWRTAKDYFTSIGAPEAATLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K9</accession>
    <name>A0A7W7T9K9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="8" type="ORF">F4559_005921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="20824" checksum="A137C0947D1F8331" modified="2021-06-02" version="1">MSEVRLAAEQRTEFGKGAARRTRRAGKIPAVLYGHGSDPKHLALPALEFARVVREHGHNAVLTLDIDSSSELALTKTVTTHPLKNYIEHVDLLLVKRGEKVTVDIPVVIVGDAGPGTLVTQDLTTVQVEAEALHIPEQIELSVTGIAAGTQIHASDLELPAGSTLVTDAEALVVAVGAAPTAAQLDGGEGDNAAEAGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9L1</accession>
    <name>A0A7W7T9L1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31529" checksum="D0DE4AAA1CE0C503" modified="2021-06-02" version="1">MANPPPLARRIELGALLRTYRERAGLDVSDVAETLGWSYVQKVGLVESGKRKLAPTEVTTLADLYRLDEHERDKVVALGVQARKRDPGPEFVADFALTYVALEAAASHLKVYVEELLPGNLQTEDYARAILTEGGLLAPNEIDLAVTGRVERQRRLVEPGAPRLTIVLSESALRRQVGGAAVMRGQINHIRDLAQRPNVEFHLLPFDAGAHLALGTWFNLIHLGDPAVTFVYVEALTSSEFYDRPPHTEVYTLAFDRAQRAALSPDVSLERLDQLTKIHSSEQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W8</accession>
    <name>A0A7W7T9W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-serine deaminase-like pyridoxal phosphate-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="42028" checksum="B6A3981DE62EE61B" modified="2021-06-02" version="1">MHSRARLDAATGGFDPPFAIVDLDAFDHNADDLVRRAGGLPIRVATKSVRVRALLDRVLRRPGYAGLMCYSLPEALWLSDTDTAEDLLVAYPTVDHAALRALAADATARRRVTLTVDSVAHLDLVDRALGADHPEIRVCLELDVSWRPLPGLHVGARRSPVHTPHQAAILARAIARRPGFRLVGVMAYEGQIAGLGDAPPGRPALGAVVRWMRRRSGAELAARRGAAVAAVRDHADLEFVNGGGTGSLETTRTDAAVTELAAGSGLVGPTLFDGYRAFLPQPAVLFALPVVRRPTRDVATLFSGGYIASGPTGHDRAPTPYLPAGLELMAFEGAGEVQTPVVGPDAAALAVGDRVWLRHAKAGEPAERFTHYHCVRGTAVEETVPTYRGEGRCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA93</accession>
    <name>A0A7W7TA93_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase</fullName>
            <ecNumber evidence="3">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="449"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="554" mass="60848" checksum="8EBCECEA4E10F913" modified="2021-06-02" version="1">MGNTERFRRARDLLLDLGHDHDAAYAEFRWPEFTEFNWALDWFDAIAADNHRTALHVVSGDTGERLSYVELSRRSSVVANGLRALGVERGDALLVMLDNQVAVWETMIAAIKLGAVVIPTFTTVSAADLRDRVTRADVRHLVTTSDLARSLDLPPHVTRIAVGEPVPGWRSYADLDGADEFVPDGPTRADDPLFLYFTSGTTSRPKLVRHTHVSYPVGHLSGMYWNGVRPGDVHLNVSAPGWAKHAWSSFFVPFNAEATLLSASAADPVELLDHLVAYEVTTFCAPPTVWRMLIQHDLRRWSVRLREAGSVGEPLNPEVVDRVRAAWGLTVRDGYGQTETTAQIGNSPASRVKPGSMGKPLPGYEIVLVDPHTGQVGDEGEICVALDPVRPVGVMTGYVDDDEKNARTFADNRYHTGDIGRRDEDGHLHYVGRTDDVFKSYDHRISPFELESVLLAHEAVAEAAVVPAPDPVGLVVPKAFVALAAGFEPSEETARRILDHTRENLAPHQWIRRLEFAGLPKTTSGKIRRAELRTRTGGVEYLADLPAGAAPGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC5</accession>
    <name>A0A7W7TAC5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19226" checksum="A10A202EBD202837" modified="2021-06-02" version="1">MSHTTNRAVDCVLFLRDTLALSVETVPELPGLDPSVPVVVPPGVDRAAAADEWLGWWADVLDHARDASPGRSPIDPDGPSLAGRPASRAALRALLPAFAEYSARRPRRAGALPVAEVVRGVRYRLGRPVKPFRLVITVVAVRGLVWERTTATHVIASEHFLDDPGRGAPALRAIVETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCJ2</accession>
    <name>A0A7W7TCJ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21844" checksum="163F01D99992B836" modified="2021-06-02" version="1">MSSTPARIADTDDARSLAAIEVPVPELPGSAEELAAAAATRLGWHGVVLPEMVLMGRRIVVVAELLADAHAERVCLGAAPEVDRTTVSTWVWPEMDGRVPPAAVRIVGVLAVARHWRTALASAVPFARFGNAAAVLPSSVAFTHDYLTNCLPRVRRYGVSVLLADEELELTTDVAGRNESVPVEDTATTRWVNELVYEQVLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCY9</accession>
    <name>A0A7W7TCY9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031390129" evidence="1">
        <location>
            <begin position="28"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="37"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="39801" checksum="A75EA49ED1471647" modified="2021-06-02" version="1">MLRSKIVGVALAALAVAGVVTLPSASADQGGEKARGPLVIGHRGASGYRPEHTLASYELAARMGADFIEPDLVSTKDGRLVARHENEIGGTTDVAAHPEFAGRRTTKTIDGVAITGWFTEDFTLTELKSLRAKERIPQIRPRNTLYDGRFPVPTLEEVIDLARSLSRDLGRTVGVYPETKHPTYFQDIGLALEPKLVDVLNRKGLNRPGAAVYVQSFEVANLKWLRGKLRVPLVQLIDASGAPYDFVKAGDKRTYADLVTPAGLKEIATYAKGIGVAKDRIIPRDANGFLKQPTTLVADAHARKLIVHAWTFRNENAFLPADYRSSTDQAAYGRAFDEYAKFFATGLDGVFADNPDTAVEARKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTD6</accession>
    <name>A0A7W7WTD6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="519" mass="52510" checksum="8E94EAD3DE5A5952" modified="2021-06-02" version="1">MPVLPTTSHAATEYAVRPPEFSRAERVRVLTLTAAGSVVIGYAAVAALLALVSSTAAHAAFSTTGVLAAAAPGWLAAHHVPLRFDGGQLGVLPLLPTALVMLLVHRAAASAADRLGLFEPLQARAVVLGIAGAHATVGGLIAFLMGDEGEGVRATPAVAFFGCAAVSGVAALSGVAQRCGLVDLLFERVDPVARRGLRAAALGLSALVAAGALMFAVGLLVSWSTTSLLFDGTVGTGLGLFLLCLAYLPNALVGAVSFVVGSGFSIGVVQVGPLSSTGGPVPAVPLLAALPEQHVAVLPLVLILPGAVGVLVGWSLRDAAGRPAARARAVLVAAVASAVVVLVLAAVAGGALGGGVFNPVTIPAGLLALLTFGWVLVPGGIVAWFAGPKAGAEVEPDSGTAAAVVEPDADSDSDEPADEDLPEPVAEEDEPEAEDDADSDSEDDLDDDPEDHPDGDLTGESDDPEDLDDESDPDFVDEEDLDDYFDRDADDEAVTTDPDAHPDTDTDTESEEDLPGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTH9</accession>
    <name>A0A7W7WTH9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="23694" checksum="52D97BF26D8C834D" modified="2021-06-02" version="1">MPATRTQDTSADETTAERARRFERDAMPMLDQLYSAALRMTRNPADAEDLVQETYLKAYAAFASFSEGTNLKAWLYRILTNTYINGYRKKQRQPLQQPTDEITDWQLAQAESHTSTGLRSAEVEAMDRLPDTDVKEALQRLPEEFRIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLREQLADVARDRGFLRAGRQAVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI1</accession>
    <name>A0A7W7WTI1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019639">
        <property type="entry name" value="DUF2505"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10698">
        <property type="entry name" value="DUF2505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17126" checksum="07FF4D1A81E381CA" modified="2021-06-02" version="1">MARRIEHLTSFAHPVGEVYSALVDEGHLRDRLGALGGKGGEVLAFTSDGATTSYRLRQGVDASKLPSVARGVLGGDLVIDRAEAWTAAGRTGTVEVTVGGVPGQVDGTITLSEDGTGTKLALTGQVKVSIPLLGGKLESLIADQVVELLDRETAFTDGWLDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTJ0</accession>
    <name>A0A7W7WTJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Osmoprotectant transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="36212" checksum="604879FE9CD4E440" modified="2021-06-02" version="1">MIEFRDVTKRFDDGTTAVDGLDLVVEAGTITVFVGPSGCGKTTSLRMVNRMIDPTSGTVLVDGRDVLGVDPPKLRRGIGYVIQQAGLFPHRTVLDNVATVPLLSGWDKRKARARAAELLELVGLPAEFGKRYPVQLSGGQQQRVGVARALAADPPVLLMDEPFSAVDPVVREGLQDELLRLQAELDKTIVFVTHDIDEAVRIGEKVAVFREGGVLAQYAPPAELLTHPADDFVANFVGKDRGYRGLSFVESDGVEVAPPPTSGWQVVVDEANRPRGWRAPDGVEVSGGSLYRLGDPVRGALDAALSSPSGLGVVVDADGALAGVVTAHQVVEAIERGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU01</accession>
    <name>A0A7W7WU01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="8"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="403"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="502" mass="55282" checksum="FF7598DB584BDFE8" modified="2021-06-02" version="1">MSEGSFCLVLHSHLPWLAHHGAWPVGEEWLYQAWAHSYLPVVDLVERLAAEGFADLLTLGVTPVLAAQLDDPHCLRGVHDWLGDWQLRAHGAASRLPDLAAREHRAARWALETFETRWRHGFSPVLRRLVDAGVVEPLGGPATHTFQPLLDPRLRAFALETGLRDTALRIGTRPKGIWAPECAYAPGMEEGYAAAGVERFLVDGPALRGDTALARPVGDTDVLAFGRDLEVSYRVWSPKAGYPGDPAYRDFHTYDHASGLKPSRVTGTHIAPHDKKPYEPERALLAVRKHALDFVDTVVTRLRELKARHGRPSLVVAAYDTELYGHWWHEGPLWLEAVLRALPEAGVRVTTLRGAVEAGHVGPAVHLPASSWGSGKDWRVWHGPRVADIVAGNEAVQRALLALPASADRDPVADQAVREGLLALASDWAFMVTKDSAADYARHRAEIHGDRFAELVAAARHGRGRARAADLRRVDGPFGHLDARDLTRRDSAAEDEERRCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU83</accession>
    <name>A0A7W7WU83_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21006" checksum="0199340ADBC619E8" modified="2021-06-02" version="1">MTSLGDVAACLANPENKVEQAAEALHRARELAGEAANLTATATSGSNQADVEDALSVFEEIDNAYDELAGCLAASGESIRRIRAALLGGNPTTSSDRPRLSAPTVAPARPTSEKSWAQQQRDRLPTYITSGVYIDEDGNTELVQSGRETNGEHVDIGAHLIEQGYPLGGRGRVAASERVETKVAGVNAMPESRTWTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD8</accession>
    <name>A0A7W7WUD8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20316" checksum="86A01DA7F4B6C462" modified="2021-06-02" version="1">MTAPARTGGTASTGSNPRERQLRKAAAERSRTRSAAAERAYARRAQRSGPRKNTASAPQSGVTPRAPFVVMVMVVLSVGIAAIMWLSTQATADSYRLQDARAEETRLARQVEQLRQEVAMAESPLKLAEAAQALGLVPAGDPARLRRLPDGTVEVYGKPSAAPEPPRPAPTTTDTPAGNTTTPPAPTTTPPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT8</accession>
    <name>A0A7W7WUT8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12675" checksum="07F2046A9B2032F6" modified="2021-06-02" version="1">MTTPTPPPSPDELIQATVAWLNALLDSASADVLGVAHYWDRAQSALITAATADTVGEAVTTAARKLQIETTQARTDTALLEACAVIAADYPAWQARVEREAVYLVALARVARTARKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW3</accession>
    <name>A0A7W7WUW3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="14" type="ORF">F4559_001232</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031095957" description="Polyphosphate kinase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_N" evidence="11">
        <location>
            <begin position="193"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="10">
        <location>
            <begin position="310"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="13">
        <location>
            <begin position="517"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="12">
        <location>
            <begin position="690"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4963873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="870" mass="95331" checksum="FA5D60B36A4B49F3" modified="2021-06-02" version="1">MSTDNSPEQPRRRTRTARTTRTASTGSATSSAPASTAAKNTTKSTAGTKTATRSAKPKAPAKATRSATAKSSTRSGSRAAAPTADSPSAPAKSTAAPAKAAPAKSTSTRSTPTKSTAAGTTTAGTTTAKTTRTRATATAGTPAAPAKTATTPRRRPRPAVRRAAVEQPVRVFPSSPPAATSTDSPADLPDDRYFNRELSWLDFNARVLALAEDASQPLLERAKFLAIFASNLDEFYMVRVAGLKRRDDTGLTVRSADGLTPREQLAGMTKRSRELVEQHARAFLDHVQPELEKHGISIVSWSQLTDFERLRLSNYFSEQVFPVLTPLAVDAAHPFPYISGLSLNLAVTVRDPDGSAERFARIKVPDNVPRLVRVESDRTSPTATFLPVEELIAAHLGELFAGMAVIECHAFRVTRNADLEVEEDRDEDLLQALERELARRRFGPPVRLEVSGDMTEKMLERLLREMEVDPHDVVQVPGLLDLSCLWQLYSVDRKQLKDPPFVPSTHPAFGERETPKSIFATLREGDVLVHHPYDSFSTSVQRFIEQAAADPRVLAIKQTLYRTSGDSPIVDALIDAAEAGKQVVALVEIKARFDEQANIKWARALEKAGVHVVYGLMGLKTHCKTSLVVRQEGSHIARYCHIGTGNYNPKTARLYEDIGILTAEPTIGADLTDLFNVLTGYARQDNYRSLLVAPHGVRRGIVERIEREIEHARGGERAGVRIKVNSLVDEQVIDSLYRASQAGVPVDVVVRGVCALKPGIPGLSENIHVRSILGRFLEHSRLFHFVGCDEYWIGSADMMHRNLDRRVEVQVRVTDPKLIAQLDEVLDSALEPTTRCWVLGADGEWEASPSDGSRVRDHQTELLRKHDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV79</accession>
    <name>A0A7W7WV79_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="97"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="471" mass="52097" checksum="B250CCC37AAE8259" modified="2021-06-02" version="1">MTVTDSLTPDVENEQPRLSLGTAAARNLATTTKSVPQMQGITSRWLLKVLPWVEASGGAYRVNRRLSYAIGDGRLSFTNVGAEVSVVPQELVELPLLRDFDDVEALTALARRFRQREYEVGQVIVEEGRPKNEVFLIAHGKVDKIGAGEYGDQTVLDVLATGGYFGDQVLAGPQGEWEYTVKAVTPVIVLSLSWDDFEQLNGEAGALRSHIQRAYSRGVKKQNVHGEAEIDIASGHDGEPDLPGTYVDYELAPREFELSVAQTVLRVHSRVADLYNQPMNQVEQQLRLTIEALRERQEYEMVNNREFGLLHQADLKQRIHTRSGPPTPDDLDELLATVWKQPTAFLAHPKVIAAFGRECSKRGIYPSNVDLGGNQVPAWRGVPLLPCSKLEISSKRTSSIMLLRAGEDNQGVIGLHQTGLPDEYQPGLSVRFMNVDEKAIISYLVSAYYSTAVLVPDALGVLENVQLGRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB1</accession>
    <name>A0A7W7WVB1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21244" checksum="C7015200800C7F21" modified="2021-06-02" version="1">MNTGRLFVKTNERTVMPNTGAPLEVIAASLRRERERVGLSLSELAKRAGVAKSTLSQLEAGNGNPSVETLWALGVALDVPFSRLVDPPVRQVTVIRAGEGAAVHSERAPYTATLLSSCPPGARRDIYVLNLEPGAPRESQPHMAGTREHMVVSTGRVRAGLTDDPVDLGPGDYLVYPGDLPHTAVALAPGTSIVLVMEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP2</accession>
    <name>A0A7W7WVP2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="163"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="326" mass="34238" checksum="CB0B0C8DB10D72A0" modified="2021-06-02" version="1">MIDGFEGLDVAVVALGDVDSGYAERVAGELRRFGHRVVLSTTGSGTPGSAGRRGTAGGVDVVHTLSEKSLRAVAALRSAGTPVVHSRRPGDPVESCAVVDHVVVGSRADLDVLIRSGVPRSATSVVVEAVDNARWSVEGPVRSRTKGFRVVCRDSLWRGGGADTAIAALPWVPNTELVLAGRGGPRGSSTPAEVERLSQGARALRVADRVRIVGRADPALVRSADVVVQVPWTAGSTRPVIEAMACGVPVVVSTVGGLPETVLTEVTGLVVPPRDPKLLGLVLRRLLTDKVRLAAFSIAAADRVEQRHTWARFASGITRAYREVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVZ5</accession>
    <name>A0A7W7WVZ5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="32089" checksum="51B8967A89C74A76" modified="2021-06-02" version="1">MDGIDRGVGVTALMVAAARAIEHRRPDALAHDRFAEHFVRAATVSRAWPVHPREVPEGDAHPVWGRLARYFGLRTRVLDDFVAESTQVVLLGAGLDSRAYRLPWPRGTTVYELDQAGVLGFKHHVLDRSGVDPAAGRVPVPVDLRRDWAPALLAAGFDPARPTTWLAEGLLLYLPAVAEQALITAVDRLSAPGSRLAYEIKSVREVPRIRDSPVYRRARQEIGVDLLGLFDDDPRPDSTIALTSYGWRTSTRTPFHFTDVHGRGPRPEPHDALAANRWIFADKITAKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW06</accession>
    <name>A0A7W7WW06_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD superfamily hydrolase (TIGR01490 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="24575" checksum="EE9CB75C7F5FAAFA" modified="2021-06-02" version="1">MSTRNAAAFFDVDDTLIRGNSMAGFLRHHLGSDDAVAAVAARLAGLPRAQANRAYFRLFAGVRADLLAARGREWFDPGLLRPDTLEALRRHANAGEPVFLVSGSFFACLDPIAEAVGATRAFGTRPVVRGGVLTGEVLAPMLDGVKAEVVRLTAAVLGVDLGRCSAYGDHATDLPMLRLVGHPVVVGDDPVLTSWARGRGRAAGGPGGGRVRTPTGARAAIGGTPGPATGAAVRPRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW42</accession>
    <name>A0A7W7WW42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="35592" checksum="E2DADCC74C690CDB" modified="2021-06-02" version="1">MSDESRSLTLPLLVLTVVLLVSIVVGIALGPTTVPLPDVLSFLWKAVTGGTIRPDEVTGYSIVWHVRAPRVLLAAVVGAGLSVVGVAVQALVRNALADPFVLGISSGASVGATAVVVFGVFSGLGVLALSTAAFLGALGATVLVYVTARSRLGLTPLRLVLTGVALAYAFQAVMSVLVFLSPNGQSAQTVLFWLLGSLGAATWSSLPLALVGVLVAVVVLLRNGTALDVLSLGDETSASLGFDATRLRRWLFLLTAVVTGLLVAVSGAIGFVGLVLPHVVRMVVGSGHRRVLAVSPLAGAVFLVWVDVVARTLVAPEELPLGVITALIGVPVFVVVMRRRGYAFGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW72</accession>
    <name>A0A7W7WW72_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="26360" checksum="6CC6A1DA3B2B6FC0" modified="2021-06-02" version="1">MSTAEEPTRVVVVTGAGSGIGRATLDLYLDRGWQTVAVDIDPTGLADLADHPNVATVIGDVASERTNTEAAKAALDRFGRLDAAVLNAGYGGGGPLEAPGALDRLAEVLSVNVIGAAAGIRATAPALRASGGGAIVVTSSVSGLRGDPSTWAYNAAKAAQINLVRAAAIDYAAENIRINAIAPGGTVTAMTRAQVEHPTFGATIARRIPLGRWSQPGEQAEAIHFLTSPAASYITGTVLSVDGGLSANGGILLPPAGPGEPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWD1</accession>
    <name>A0A7W7WWD1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="677" mass="72413" checksum="AA8A18858CB554AB" modified="2021-06-02" version="1">MPRYSSEHHVVLDGLRHEVLRTGTPGAKEESLLTLRSMVSTARRDAAVEGTGTTAAHHAAALVQLAETEFATAEFEASALSFDAAEAVLRRGPDLPPGDRPGRDWADGLAEVRIMRSRVNGMLRRPLSAIADVQRALDHDARAHLAQAAWALTLAGYDPEVVARMADADMRSATGARLVLAARMSAVAHDRLGASDAEQRAWLATLGVDHRRVLAVDVRQSARPAPPVRTIADVPRGAALDEAGFVVSRLGGDALVADLLAHQRKAAGDEVIALGLEVHALCALSDVPTADRVESLILLGDAYADEGDVAQLDDVVRWLRRLARQGEVPRAEAVRLAARLEARVVEPVVPPGPAMEVAVLSLMDIGVDVPDRAADAFGLAAELLAVAVRDRPSEPCFRQYGATLYASAGALIADDDFEAAVRASDEAEKAYSRVSGLDERIADVRLRRARALASLGRPLGVVADTQRCLDHYADRPVPGRVLAHAAFAWWIVGVDPHRTARAADTVLAGRPEDDRASAVIAAQVSYRVHRLLGERPTLAYDALKALGELAWPEAEDGPVFPLSLPRRLSAVLRPEVAGPERFVPARLVGGKADRVCAKLLALARDLPPAEAVAVALEIHAVRSPAGVPTPDWADAVAILARAYGRLGLAPAAAEAEELHARLDRDRPRSFLARLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWE2</accession>
    <name>A0A7W7WWE2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="724" mass="79102" checksum="A6E1003159B3D477" modified="2021-06-02" version="1">MTSPIVSADPVGRSPFAGLDLCRAIGITVAPGARGPNFDQDVWDFNSVTDLAAYMATSHKSWNLAAIRNPLWRVLAKEYLVALMVPTHEAVRELPSAFRVARTVPACVNKHYELIRWLNWLTDNGVTELGQITDHFCESYIAERRTGHDKDGAIIEKRGAVNGAAQVVSGLAQYRDLFTTDRYPAGFRPFGGKAAVAVAGLKTPAENSTPPVPADILQPMLAAALYIVDTLGPQVVSLTRHVTAERERINRLPQPRNPGWGVLLRAINQRVAEGRPLNRVPSRIEPITRYAVDESDPLWGISLRDVAAEAAFGHFRGEWLAVLRPALERAVAQVGIDDPYGRDGPLVARADGQGEVPWTLPLSERHARVLPDVVRTACLLVVAAATGMRSSELFELAMGCRLAPERKAAGLVRYRLAGKVIRHRGYGGEADEWVVVGQVHRAVALAEQLLDADAEPGTLLFGRTVFKNTYGTFRKWVNGPAGQRLGLAPIPEAPEELRMLRRTLAIELAYRPGGLLAAKVALKHTSVVTTEGYAGRPGGAQAKFLVEVGKEEQKRNLGLLVDEIGNYQRGIRPAGPHAHELIEFFAAVDGKLTEEQRAAPKIILNDQELRRMLAKRAKTLHLGVANYCWFTDPGKALCLRLAGTPTADRPLIGMCDSARCPQATHHPCHRPVWDQAVQSTTVFLGNLSRGQTGEKARLETQLARARHVLADLDTATAGTDEERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWI9</accession>
    <name>A0A7W7WWI9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="2"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="36809" checksum="96A1A67BF26061A3" modified="2021-06-02" version="1">MPDPAAFWRLLRTGTDAVTGVPPDRWADGPAWGGFLTGVDRFDAGFFGISAREAAAMDPQQRLALELAWEAVEDAGIPATDLRGTDTSVFMGAISDDYAVPLRESRADSSADSRADSGSVFGAYHHYAGTHRSLIANRVSSVFGLRGPSLTVDCGQSSSLVGVRLAVESPRRGEASVALEGGVHLNLVGNRALTDFGALSPDGRCFTFDARANGYVRGEGGGLVVLKSLARARADGDRVHSLILGGAVNNDGGGAGLTVPVADAQADLPRAAYRDAGVDPAAVHYAELHGRATQPLRPRCGPRPRDCTTTSRRVVGGRRMSPSRSPRHGRRRPVVRRWWPTSGTCSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM4</accession>
    <name>A0A7W7WWM4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Choline dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008812">
        <property type="term" value="F:choline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="478" mass="51355" checksum="C6B8E94117E8EE4A" modified="2021-06-02" version="1">MDADYIVVGAGSAGSALARRLLDRTAGTVLLLEAGDSDTNPAIHDPMRMHELWDSPQDWGLRTVPQADAADRSLHLPRGKVLGGSHALNAMIHVRGNPIDYDDWAARGCTGWSWADVEPVFERLEKGPLTILREPAVDPVQEAILAGAQAAGLPYNPDYNSGDQLGVSRMQFTIDAGVRHTTARAYLGPVLDDPRLTVVTGAHVRRLRIEAGRCVGVEWTVGAESFDARANAEVVLSSGAIGSPLLLLRSGIGPADELRALGIDVVVDLPGVGRNLQDHWLVPVVFGSTRPVEHLPGLPHAQTHLFWHSRPGLPGPDLQPLHFSVPLYDSWMKGPAEGFSLMAGLIRPESTGRITLGGPDPDALPLIDPRVLSEKSDVDALVAAVELCREIGNSTRWESTELYPAYHDVREYVRRTVVTYHHQSGTCAMGSVVDPDLKVRGIEGLRVADASVMPSIVSGNTNSPTIMIAEKAAELIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM9</accession>
    <name>A0A7W7WWM9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylhydroperoxidase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="2">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10411" checksum="1D8F90DF7D1CFAE0" modified="2021-06-02" version="1">MSARFDFPHNEFAAKFTKRFVGLAQVMRQSSLSHTVQELVSLRASQINGCGFHFAQTCTSKVDGSPRKCQVRRAGNELTHRSGKGTRGQTARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ0</accession>
    <name>A0A7W7WWZ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Natural product biosynthesis luciferase-like monooxygenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024011">
        <property type="entry name" value="Biosynth_lucif-like_mOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04020">
        <property type="entry name" value="seco_metab_LLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="37597" checksum="A76A91743A979C56" modified="2021-06-02" version="1">MDYSLFYFADDSASSGGGRYRLLLDGAKFADEHGFTAVWTPERHFHRFGGLYPNPAVTGAAVAAVTSRVGVRAGSVVAPLHHPLRIAEEWSVVDNLSGGRVGLSFASGWNANDFVLAPEKYADRKRELVRTIDQVRSLWRGGSVSLPDGAGSPVSVRVFPPPVRAELPIWTTSAGSTATFRAAGEAGTGVLTHLLGQELDRLTANIAAYRAAHLAHHGTPGHVVLMVHAFLGPDADLVRERVREPLVEYLKSSFHLIAGSVTDLDPARLRPADIDFLIRRSYDRYYETSGLFGTVDHVRPLVERFRAAGVDELACLIDFGLPFDAVLDGLTTLDELRASTVLEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX16</accession>
    <name>A0A7W7WX16_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="38134" checksum="9778C93DFD2ADF3B" modified="2021-06-02" version="1">MPLTFDALVSGVPGEAGVCGHCATAEPVPAAPQVDRSALLDRIFAVYRGAPVEPGEGYESVLRTLPSAGGDIDGVVLYSGGKDSSWMLADLVHRGLKVVAWMLDQGYQSPAAIDNARFLCDRLGVDLVIAKPEREPMDNLFRIGFGIPDQGDPELVRSAMTFGSACWPCFATISARATVFCRENDVPFCFVGTHKGQNRVGDETAMAQTFLPPLSAAADGFVAPLRDHARTRAPESADLLDTAPSRTILVPFYEFVPRPAREDLIADLEAMGWRVPRNTGSCSTNCMINELGCQVMRHQYGFDVYQVFEAHERRLDPEAGPVRPGPLDEAAVRRGARLIGLTPEEERAFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX19</accession>
    <name>A0A7W7WX19_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="19843" checksum="61A46EE44BE9BF41" modified="2021-06-02" version="1">MSEFDKHFWAERYAHPGGHAHGPNAHLVAAASELPPGRALDAGSGHGADARWLAARGWRVTAVDIAAPAVVADGVEWITADLAEWVPDVDGYDLVTSHYVHPMTEELVARLAASVAPGGILLIVGHDPDDRHSAHSSRLTAGQISSTVDGDGWEVLVAEARTVDGPHGHALRDAVFSARKVVGGGWAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE0</accession>
    <name>A0A7W7WXE0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aamy domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="12"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="476" mass="52820" checksum="4A8CDF27E31E3E4E" modified="2021-06-02" version="1">MSGWPDRPVIHQINTAVWLDSLSRQERRVVTLGDVPESTWDALCGPGLDAVWLMGVWERSPLGLELSGRPIGPGAVGSPYCVRRYVVDAAFGGPDGLAAARETLARRGVKLVLDHVPNHVAPDHPWVAERPELFVRGTPADLAEAPSEWLETPGGVLARGRDPYFPPWPDVVQLDAFSPDLRAATAETLTTIADQCDGIRCDMAMLPTNGVFARTWHGRTGPAPAAEFWPSILDTVRARQPGTVFIAEAYWDMEWTLQHQGFDFCYDKRLYDRLIGLNPGAVRDHLDADPDYQARLLRFLENHDEPRAASRLPVDAERAAAVVVATLPGATLWHEGQYEGRRAQAPLFDRRLPDEQVDVGLAAWHRALRAIAAQVRTGTWEQLEPECWPDNHSGRELLAWTWSPPVGDRHLVVVNLSPGPAQARLRLPWRHLAGRTHRLADLLSGTAFDREGDELAEQGLYVALEPWGHHVFAITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP7</accession>
    <name>A0A7W7WXP7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase-3</fullName>
            <ecNumber evidence="5">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="4">
        <location>
            <begin position="113"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="3">
        <location>
            <begin position="245"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="35646" checksum="030DFCD229D81F80" modified="2021-06-02" version="1">MRFEDIWIAGTGGTLGDRVPVEHAIADGSYSADVARGTGMISVAQATQAPPELAVTAGRQAIKAAADHGVVVDRATLHLHSHSNYQGLDMWPVASWVAKELIGTDLEGQPTVVQAASNGSLTSLDLAATALQAGRAETALITLGDRFAEPVDRWYLSPGMVFGDGGAAAVVSRRAGLLRLDSIVSETDAALEGLSRGDEPFGTESVPRPDMRKRTRAFLARSGISLSEVRRRSGDRTVSVVTRALTEAGRTLDDVDWFVTPFVGRALFQDSFLRPLGFTPRNTLLETGLTIGHLGPADQLYALAHLVTEDLLRPGSTVLLLGTAMGFTFSAAVLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY73</accession>
    <name>A0A7W7WY73_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24352" checksum="185EDA823C472F63" modified="2021-06-02" version="1">MTDLLDLIARRDYSTESDVVRAMPMVLRIERADPPSRTDVLEAAAAAAIAVCLDDRAAVDGEWHPALEAWIRGRIRKVSRRARGAHWAAVQELPGVTITVGTASVRAFVPGPVTELPKELSRLQVAGSDLPPDTPGPVPEGARVLWVNPRVEMTAGKAAAQVGHATMILAPRLSAAELKEWAAVEFRTAVRTPSPADWDLLVAGPDPVVVRDAGFTEVAPGTATVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ6</accession>
    <name>A0A7W7WYJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative FmdB family regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="9731" checksum="35FFAF4C5C713EE1" modified="2021-06-02" version="1">MPTYQYACTECDHRFEAVQSFSDAALAECPQCTGRLRKLYGAVGVVFKGSGFYRTDNRSSATGSSSTTTSAKTESTSSASTKSESTSSTAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS8</accession>
    <name>A0A7W7WYS8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tricorn protease homolog</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_005911</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades oligopeptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036421">
        <property type="entry name" value="Tricorn_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="TSPc" evidence="11">
        <location>
            <begin position="811"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="1008"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer; via amide nitrogen" evidence="9">
        <location>
            <position position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036421-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1058" mass="114362" checksum="406A9D5C66F131DC" modified="2021-06-02" version="1">MTESAYLRFPHLHGELVVFVAENDVWLAPVSGGRAWRVTADQVPVSSPRFDPTGTRLAWTSRRDGTPEVHVAPVDGGPSTRLTYWGDTYTGVRGWTPAGDVVAVTTAGQATGNRQWAHAVPVDGGPARRLPYGWVEDVDHGPDGQVVVTSVYGRDPSSWKRYRGGAAGKLWVAGPDHGFHRVLDHLTSSLTSPTWVGGRLVFLSDHDGVGSVYSVAPDGSDLRRHSAQEFYARNATSDGERVVYQHAGELWLLDGLDAEPRRLDVALAGPRTARRRRHVSAHPEDFHPDKSGRASVVEVRGTVHWVTHRDGPVRALAEQPGVRARLPRVVGDSVVWVTDAEGEEGLEFSPVGGVEPGNTPRRVAVGRLGRVLELEVSPDGRRLAVATHDGRLLLVEAESGEVREVLRDAGPWVSDLAFSPDSNWLAWSHPGPWPLRHIRMTNTTDLSVVDVTPLRFADTSPTFTEDGRYLAFLSVRSFDPVYDAYVFDLSFPTGTRPHLVTLAATTPSPFDPLRLGRPVGDDSSDKEKDKDDDNPITVVDLEGLADRVVALPVAAARYSGLTAAKGGLLWLRSAVRGVLGDNQASPTSRPPRAVLERFDLAKTRTDALADGVDAFAVTGDGQRMVVQDGGDLRVVPTDRKVDADDNDSISVDLARVRVEVDRAAEWRQVYAEAGRLMRDHFWRADLGGLDWAGVLDRYRPLLDRIGSYSDLVDLLWEVQGETGTSHAYVYPAGGGGRGRGVGLLGADLERDASGAWRVVRVIPGETSDPAARSPLSAPGVAVRAGDAIVAVDGRQVDPLRGPAPLLVGTADKPVELTVRPGGGGEPRRVVVVPLGDDRALRYHAWVADRRARVRELSGDRVGYLHVPDMVGSGWAQLHRDLRVELRHEAVVLDVRENSGGHTSELVVEKLGRKVIGWETQRGRDTATATSYPNDAPRGPVVTVIDEFAGSDGDIVSAAIKRLGIGPLVGTRTWGGVIGINPRHSLVDGTVVTQPEYGVWIDGVGWGLENHGVDPDVEVVITPQDRAAGRDPQLDTAVRLALEALELRPAAVPPELPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ34</accession>
    <name>A0A7W7WZ34_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="10235" checksum="17398DC20BD6F1EC" modified="2021-06-02" version="1">MFRYGRWKTSWRTLGVMALSGALFALGVFLMVHLWPGYLPGRYSPEFSRILLSFVMILFGGLGCWVGIVDLEWGRPGRHSVERRTAVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ66</accession>
    <name>A0A7W7WZ66_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IMP dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005991">
        <property type="entry name" value="IMP_DH-rel1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01303">
        <property type="entry name" value="IMP_DH_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="95"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="479" mass="49946" checksum="CECBDF16ABD3617C" modified="2021-06-02" version="1">MRFIEGHRPSHDLTYDDVFLVPGRSAVESRFGVDLSTFDGTGATIPVVVANMTAVAGRRMAETVARRGGLVVLPQDMAPDAVAEIVGWVKARHTVWDTPLTLEPGDSVADALNLLHKRAHGAVVVVDGDGRPVGVVDEGALAGVDRFTRLQDVLDERVVTVTLGTPSREVFGLLHGGSQRVALGVDGDGVLRGVLTELGALRAEVYAPAVDADGRLRVAAAIGVNGDVRAKAADLLKAGVDTLVVDTAHGHQEKMITALHAVRSLEPGVPVVAGNVVTAEGVRDLVEAGADVVKVGVGPGAMCTTRMMTGVGRPQFSAVAECATQARALGKHVWADGGVRHPRDVALALAAGASAAMVGSWFAGTYESPGDLHRDEAGRLYKESFGMASKRAVSARTRSDNAFDRARKGLFEEGISASRMRLDPARAGVEDLLDSITAGVRSACTYAGATTLEEFHGRAVLGVQSAAGFAEGRPLPAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA5</accession>
    <name>A0A7W7WZA5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12331" checksum="838B5BAA9DAFE016" modified="2021-06-02" version="1">MADQLALAFADRHAGHEANLAAATAAHRRYRETVETVLADLVAAGAPFTADDVRKAIPDDVAAEAHSPNVLPSVLGTWAARRVIVSCGEYRSRRRSRRASRNRVWIARTAEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X034</accession>
    <name>A0A7W7X034_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="10041" checksum="9BCB3DDE8C410F95" modified="2021-06-02" version="1">MARFVVEWEYFEDGGPRAAARPAHRDYLDTLVEAGKVLGAGPWVDDSGALLVYEVADRAELDALLAADPFTTAGVVAGTRVHEWKTLKGPWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXB8</accession>
    <name>A0A7W7SXB8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19382" checksum="5F0DD3EC09A86887" modified="2021-06-02" version="1">MSIGHTLLGLLEGGPRHGYDLKRAYDARFGQDRPLHYGQVYTTLSRLLRNGLVEEAGVEAGDGPDRKRYSITDAGVTDVEQWLATPEPPEPYLQNTLYTKVVLALLSGRPADDVLDLQRSAHLAAMRELTRRKAAGDLADQLICDHALFHLEADLRWLELTAARLGDLREKVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXP9</accession>
    <name>A0A7W7SXP9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="6" type="ORF">F4559_000157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="390"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="541" mass="56961" checksum="0CDB38383EBEBD95" modified="2021-06-02" version="1">MNPSTAQAEVLVDELIRNGVRHVVLSPGSRNAPLSFALERAASAGRLALHVRIDERSAGFLALGLARGGGEVTAVTCTSGTAVANLHPAVLEARYAGVPLIALTADRPVELYRTGASQTVDQHGLFGLDTLQFPIAERRAGQNGLWRSLVCRAVATARDGGPVHVNVPFREPLVPDGSAWDLEDLDGRPFDQPWTRVAPRTTTSVHSADHLGPRTLVIVGDGADPAVLDLAERAGWPVVAEPTACGLRHGSLLLNADTLPPELTPDAVVVAGRATLSRGVLAVIGLARVVHAVSAHPEWPDPRFAVTHTSTHLVLGEHEVDPEWLTAWQHADKAAADVVSELLAAQPWPTGLHVARDLLRSLPSGTNLFLGSSNPVRDVDLVAVPRPDVTVHANRGVAGIDGSVSTAAGIALSAGPTVALLGDLTFLHDSGGLLVGPLEERPDLTVVVLNDDGGGIFTLLEQGAPEHAAGFERVFGTPHGVDLAHLCAAHHVPHVLVGSPDELRREVSSVRGVKVVEIRAERAELRELHARLKGAVSMGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXW6</accession>
    <name>A0A7W7SXW6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">F4559_000357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="123"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="29240" checksum="DBCC705D42032D2C" modified="2021-06-02" version="1">MTATILNGRATRDSIFDGLRARVAALVERGVTPGLATVLVGDDPGSHSYVKGKHAACAKVGITSIRRDLPADTTQAQLEAVIDELNADPACTAYIVQLPLPRHLDANAILERIDPAKDGDGLHPVNLGKLVLGDEAPLPATPRGVVELLRRYDVPLAGANVTVVGRGVTVGRPIGLLLTRRSENATVTLCHTGTKDLAAEVRRADIVVAGAGSPGLITADMVKPGAAVVDVGITRTEAGLVGDVHPDVAEVAGFLAPIPGGAGPMTIAMLLTNTVEAAERGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY66</accession>
    <name>A0A7W7SY66_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17698" checksum="B5B80090CBCB8249" modified="2021-06-02" version="1">MDPRHWLEDYAGRIEEIRKKSVELQENVANAGARVESKDGSVTVTVNPNGGLQNLQLGHRACDLGPARLTTLIMETVRQAQRQAAANVVAAFEPFGGGTEAMRLIVDSIPTDGDEDAHGDYDAYAEPEPEPVRPPVPQPAPAPSRPVRRPAAADDVDDDNRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY95</accession>
    <name>A0A7W7SY95_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ORF">F4559_000250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15745" checksum="CD8283CE0AE627F5" modified="2021-06-02" version="1">MLIPRRLKHRKQHHPGRSGAAKGGTRVTFGEFGIQALEPAYVTNRQIESARIAITRHIRRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVLFEMSFPNEAVAREALRRAIHKLPMKCRIVTREGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY99</accession>
    <name>A0A7W7SY99_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">F4559_000537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="103" mass="11709" checksum="C0BD89296286829A" modified="2021-06-02" version="1">MREFDGGRIVDGVDVPAPEPVVFTGLFDATEEQDWQERALCAQTDPEAFFPEKGGSTREAKRICLGCEVRSECLEYALQQDERFGIWGGLSERERRKLKKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYJ8</accession>
    <name>A0A7W7SYJ8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14499" checksum="E6F7B33D8453B2D6" modified="2021-06-02" version="1">MPKGDVITVRQILDHTSGLYDYAHEPHLSTNRRRGTARFRSYQPRELLDVAFGHPSNFEPGTDWRYSNTNYVVAGLLIEQSPVGPMARRSPDASSNPWACGTPACPATGRDCPVRTPAATSRSTDAWSTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYM3</accession>
    <name>A0A7W7SYM3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="40242" checksum="FDEE03E92BB642F4" modified="2021-06-02" version="1">MTQSRLAQAMGVSEEHLGKMERGLRTLTQGNAARAAQALGTPLDEVLGRTPVDVRTEADLGELRAVIRRFDLPGERPRVDFRGILTRTKRIGGHVKSADLAALIDELPEFLTIATDHAHATGKPAAWEVVTLGYSAVYYLAARHRWMDLAELAVVRQKAAAERATPFAPVIAARDEAGAFLNSGDFPGGLAVVDRALVRAQAELSGRERTLAEGVLRLRGMTLAGRLRDRAEAERHITGARDAASAITEDVTDSGRMFGPQNTAVHVAATLADLGRYRESADTADELKRTKLSLPPTRVMNLFVDDSRTRLALKDRDGALMSLRLAFEAAPQKAKVHPTSQEVLRVLVELHRRSNPDLRKLANTMGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ2</accession>
    <name>A0A7W7SYQ2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="8280" checksum="34659E9E8FC88771" modified="2021-06-02" version="1">MTYVVTSRCVGTKETSCMTVCPVDCILDIGEQVVIDPVECVDCGACVDVCPVDAILHESEVDDPAVVADAYGRFGLAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ8</accession>
    <name>A0A7W7SYZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="2">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21288" checksum="E2E91E7E9C728CE1" modified="2021-06-02" version="1">MKLTTMTQVTVDGVLQGNGATSDDPRNGFERGGWAIGRGDDETHAFINRTYARADAFLFGRLTYGLFAGAWGSWAEQDVPGWEPVLRALNTRPKYVVSSTLTAPTWSGTTVLSGDVATAIAALKAVPGGELQVHGSGALVRWLLANELVDELTLLTIPVVLGQGTRLFPDEGPDLALDVVESRVDSKGVTIQVYRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE6</accession>
    <name>A0A7W7SZE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="25271" checksum="EF80AF32CFBE9E8E" modified="2021-06-02" version="1">MTSLSDVAHTLRTAADTLPIALLADAADAAEAAATLLAHTTVGTSDPEIIATTDTFAEAYRRCTELLQTAQALHTHINTLADHLAPDTTPSAPRIEKTSQALPRRPRGTEAQGRWVRADGDTVVLRSGKRDEWHDRALDFIRATTGTVKHPVSRLATHVEVKLAMRMRHERLTDETMVIDREVCGRRPEDRDDDYTCDRYLKYFLPRGTRLTVVERTGTRVVYEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL5</accession>
    <name>A0A7W7SZL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-ascorbate metabolism protein UlaG (Beta-lactamase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031450755" evidence="2">
        <location>
            <begin position="26"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="114"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="39647" checksum="3E4F59D7894F7376" modified="2021-06-02" version="1">MRKATAALLGVVAGAVAVTVRDVPAALGATPRDERVLRSPRYRDGRFHNDAPTNSAPSGGGMAKIVRDMLVGKQRRRPSGAVPLVAHRPGDTARGLHLTWYGHASTLVEIDGARILLDPVWSDRCSPSRHVGPRRLHQPPHSLADVGAVDAVVISHDHYDHLDLPTIRRLVQSTTAVFVVPLGIGAHLRRWRIAANRIVELDWDESHTVAGVKLTATAAQHFSGRGFKRDVTLWASWVIAGPEHRVYYSGDTGYFDGYARIGAEHGPFDASLVQIGAYGEGWPDIHMTPEEGVRAHLDLRGGLLVPVHWATFTLALHDWSEPVDRVWREAKAHDVPLAVPRPGERVDVSTPPPVDGWWQTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZP5</accession>
    <name>A0A7W7SZP5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9640" checksum="838E13A615CCF612" modified="2021-06-02" version="1">MRIRLVTAWWLASYHGWLAAVLVLATTRAVLLAAVAVVERAGRWCAGRAQAVHTILAVRDFGRDPHPDDPEFFPPHSPALDTGKDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZV0</accession>
    <name>A0A7W7SZV0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Precorrin-6Y C5,15-methyltransferase (Decarboxylating)</fullName>
            <ecNumber evidence="1">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.132" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="29140" checksum="4BBB030C53E2B7D5" modified="2021-06-02" version="1">MDVLALHGFVAETGRSWDEVAVVDAVRHGTRHALNVCRARSAVVVAGADPAELARGLSGWRRSLVVRDASGVSTVDPADAVVRRWDEPDAVLCLSETAYGAPVDAWALPDDDFAHRSDGLLAVAEVRAFVLSRLGPRPGGLVWDLAAGPGAVAVECARLGAAVVAVEGDAVQCVRIVANAAAHGVDVRVAEQDPAGACDGLPRPDAVHVGGGDPDVVRRAAAVRAQRVVVTTGDLDRVLPARDLLADAGYVVEGTQLSAARLVQGALSASNPVTVLWGTRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T014</accession>
    <name>A0A7W7T014_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="115"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="30252" checksum="E3D5768AEDBD5DA7" modified="2021-06-02" version="1">MSEAGTGQEADVVRRQSFDVETAVEVDVALMSGRVQVHLVDEPGVHVELRHDPAAGQSWAQGLNGLLSWVSDQFGGGQQGGPADAVREARVELVGERIVVHSAKALPLRAVPLSVVVRAPSGSAVAAKAGAADVTVTGAARKLDINTGTGDVTADRAEQSSQVNSGSGKLRLGPMLGGLRAKTGSGDIEVSSIGGNTVLHTGTGDVWLGAVQHDVQVRTGSGDVTLADAASGRVQLGTGSGDVRVGVRPGVAARIDLASGTGRAHSELEVSDTRPTEEPPLSVTGRTGSGNALVTTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V4</accession>
    <name>A0A7W7T0V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-amino-4, 5-dihydroxy-6-oxo-7-(Phosphonooxy)heptanoate synthase</fullName>
            <ecNumber evidence="1">4.1.2.56</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.56" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="27700" checksum="B79483A17D8A54F3" modified="2021-06-02" version="1">MRKALRLRRLSRPRDDRYLFVPLDHSVSDGPVVPADRWSDLIGSVVVGGADAIVVHKGRLRTIDPRLLGECALVVHLSAGTAHAADTNAKVLVGDVEEALRLGADAVSVHVNIGSDTEERQLADLGTVAKACDAWNLPLIAMVYPRGPRIADPHDPRLLAHVVNIAVDLGADLVKTTLALPVERMADVVASCPIPVLAAGGPADTGACLVDTARAVMAAGCAGLAVGRRVFTAPSPLALVAELASVVHGDPDADLVHYTSTMTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y9</accession>
    <name>A0A7W7T0Y9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="24747" checksum="6282933D8D1427D5" modified="2021-06-02" version="1">MDLSPIAVPPTLSRLEELLPAPPARILEAGCGRGALAAALAGRGYEVVGVDRDADMVAAAKERGVHVLHADVRDVTGEYDVVLFTRSLHHADDLDGILAHAASLAPGGLVVLEEFAWERVDRAAAHFLHDTRALLVAAGLLHADVPADDPLDAWVAGHDFLLRGSVLLDGLRRLGAEPTVVDTAVLWRLVDGRGGTWDGPADRIADVLAGVRAAEERRLAAGLLPPVGLLASVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T112</accession>
    <name>A0A7W7T112_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">F4559_001963</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20346" checksum="77A32A63FC7E35B2" modified="2021-06-02" version="1">MRARPRLTVLSGPSGVGKSSVLAELRRMGPDIHFSVSVTTRKPRPGEVDGVHYHFVDLPEFHKMVANGELLEHAEFAGNHYGTPREPVERALAAGTPSLLEIELQGARQVRAAMPEARLVMLAPPSWGVLVDRLTGRGTEDPAVVARRLEIAREELAAEPEFDEVVVNADVRSAATGLLNLVVGPVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T115</accession>
    <name>A0A7W7T115_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031003701" evidence="2">
        <location>
            <begin position="19"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13363" checksum="A4A5F63AFEACA884" modified="2021-06-02" version="1">MRRSTAVAASVALAAALAATSWYDTLSGRATPEPPHRVTPEADPAAVSTPDPTADPVPYPTPPGTAPDPAAGVPSHSPATRADADSALRAAEREARTMAACHEAAKALREATRDDDEAGSAAAFRVLFSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T130</accession>
    <name>A0A7W7T130_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6519" checksum="8BC316D7055FFAC7" modified="2021-06-02" version="1">MTPDFTAASFKTSSYTEANGTCVEVAQVPGFVAVRDTKHRSGGHIAFPDAAFRAFVARVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T175</accession>
    <name>A0A7W7T175_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">xerD</name>
        <name evidence="16" type="ORF">F4559_001765</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="15">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="14">
        <location>
            <begin position="106"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4964406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="32265" checksum="98F1FFB115DDD797" modified="2021-06-02" version="1">MQDVITAFLDHLAVERGTARNTLDSYRRDLRRYAEHLAGLGITSLDDVAESTVTGFLAALREGGLAASSAARTVVAVRGLHRFAHREGRTAHDPAHAVHPPTPPKRLPKALPVDDVLRLLDTPGDTPAALRDRALLELLYSSGARISEAVGLDVDDVDAGERTVLLDGKGGRQRLVPVGRPALAALDAYLVRARPVLAKRGGPALFLNARGGRLSRQTAWHVLKTAAERAGITREVSPHTLRHSFATHLLEGGADVRVVQELLGHASVTTTQVYTLVTVNTLREVYATAHPRARGGTAGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T195</accession>
    <name>A0A7W7T195_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acVLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040783">
        <property type="entry name" value="VLRF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18859">
        <property type="entry name" value="acVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acVLRF1" evidence="1">
        <location>
            <begin position="85"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="23481" checksum="937480A7A2BB275D" modified="2021-06-02" version="1">MRVRPVEGGGRAVEVAPALLAGWFDRFASRHGGVRATAVSPRRFVVTAEDGTTAAVDAVFADFAPTGESAGLDLRPLTGAAGASRRVGLVLVRLGGHSVGVACDGEVLVSTTDNRQVHGRSKAGGWSQRRFARRREGQARVALRAAADDVARVLVPRLPELDAVVLGGDRQALDVLRADPRLAGVFARAVERVFDVPEPRRAVLDEVAERVRAVEIVVRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G7</accession>
    <name>A0A7W7T1G7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="24955" checksum="7FE2DA68386B8287" modified="2021-06-02" version="1">MTSSTDHVDVAAYVLGILDEDEVDAFENHLAQCRRCALDLRDFAVLPDLLDEADANGVLRAHAGERPDGRSVRAMLDVVSADRSRRRRHLASGVAAAAAVLVAVTAFVTLTIAGPVDDLAVPTTVPSPSGVANNLTAAGSQLHRTDPGTGVEGRIAGVPETWGTSVQLEVRGVRGRTRCELLVTSTSGESLVMGSWLAPDARSPITFHAGTFLRWHEIAEFTIRDAAGTTLVSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P1</accession>
    <name>A0A7W7T1P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="21299" checksum="A46484BD4C26D0D6" modified="2021-06-02" version="1">MTALVRYLLADVLRAQRFLAPSLLFGAVLGMLYSSDAGPPLPAYAGACALIYPVAVWLTVVIATAEDPVRRSVTAATAGWARTQAAVTLLSAAGATALAVLATVVPVLTQSRPYPVDVVGLGFAGLLVCGLTGVGVGVVCSRPVIVPPGWSVLAASGLVALAFVVGRVPPFGAVLGVLADGDATSRVAVSAACALIFVTAATVLATHLAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q4</accession>
    <name>A0A7W7T1Q4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="25986" checksum="1D9CB7270FF17C43" modified="2021-06-02" version="1">MITLDRIGKRYGRRGPWVLRDLDLAVEAGEVVVATGGNGSGKSTLLRVAAGVSAPTTGRVRRPASIGYLPERFPSGVRMSARDYLRHMAAVRGVPARWDLVDRLGIVGDLTAPLATLSKGNTQKVALVQALQARDLLVLDEPWSGLDVVAAAALTDLLAGSDAAVLLTDHHGHEVPGARTLELGTSAVGVVIELVRVGEAFDRLGGLAGVVEVDGTGDGARVRVEAAHSDRVLAEVLRLGCSVRSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T220</accession>
    <name>A0A7W7T220_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="621" mass="67269" checksum="8CC0BDC30D8FA067" modified="2021-06-02" version="1">MTRSFAGRMAEVRLVGRLLDRDPGSPTWPPVLVYEGAAAAGKTDLLRDLDERSLGTVPSVRLDLAALEAELDDEPLPRVLAAIAFGLSRQCRLYGSLRFDRLVVGMLARALALDGVDPRAAARQVTEMLKERRGLTTLKQALGEVAQDALAFVPGGAPGAGVVTGAVGFVVDRLSTWTATRGTALGRHVTWYGDQDRGLDRDPVEVLVELNRADRRDAEDLLVDAFVADLRDDFRTGRHSSEWTMNCLLLLDGADTGLGRALVDALHAARRRQVARGVVPDTPLAVVAASRGGLLSALSKVERATVHTLTAHDTPLPEDRRVVWLRRVLPPLSPDEVYETVRGLGIDGQGHRTLASVLHQLTGGHPGGTHLVLDAVAAEGTTVVDPEKLLRSGVEERLGALLLGDVDDAALDVLVTCSAARDHAEAMPLVDRFDDVLPAGMWTADTHTTLLRLLLLRRLARRPDDHPDGRRAVHRGLRLSAEQRGDLAGRLHHALAADDADHVVAVLDDRLDTDRLTDWLALLDAVVTAPRPPGASADPAPGDPVRVLVTALRIVTDPVCGVGRGVLHWRIAGAYRDLARRVGDRAEDQEGLLDLVDRVHHHEQLGRQWRRSGRRTPKEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T241</accession>
    <name>A0A7W7T241_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="490"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="563" mass="59849" checksum="EDF472544766CBA1" modified="2021-06-02" version="1">MSEIVHELVTAQDPDRVAVVGGPVTSTYRDLDRRAGLLAARLVDLGVRVGDGVGVFLPRSVDLVVAVLAVLKAGGGYVPLDPDYPAARVSVMLDAVRAPVVITDATLADRLSAYPGRVVRVEDPLPVVDPPVVAVRPDDVAYTMFTSGSTGVPKGVAVRHRGIVRLVRDPGVVRLGPDEVVLHLSSPSFDASTFDLWGALANGGRLVVAPAGRPSVGEIADLIRSHGITTVFFPTGLFHLMVDERLADLAGVRQVVVGGDVLSSDHAHRFVTALPGVRLVNGYGPTEMTTFTTFHEVGPDQSPDVPVPIGRPLARTRVVVLDESLSPATTGQLYAGGPGLARGYLDPALTASRFVPDPDVPGERLYATGDLVRVREDGVLEFLGRIDRQVKKRGYRVEPAEVELALRADPDVRDAAVVLDGDTADTRRLIAYVVAETAAGVRARIGSVLPDYLVPDVWITVSTLPLTVNGKVDRAALPSPDLGTTPSSSAGLSADEAALAEIWREILALTEVGRHDDFFDLGGHSLLANRIVSRVRRRFGVDVPLSAVFDHPTVAGFAVLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A0</accession>
    <name>A0A7W7T2A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035348">
        <property type="entry name" value="MoaF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024724">
        <property type="entry name" value="MoaF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10703">
        <property type="entry name" value="MoaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17409">
        <property type="entry name" value="MoaF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaF" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="MoaF_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="28373" checksum="95A63C714159B7DB" modified="2021-06-02" version="1">MSDWKTVDDFAKGIDGNRLPRSSALVGTRWVLRHDDGVTTELSFVDESTVNWSVGDASGTDRYDAVEGVPGTFFVERTTDANERVAEVHVVHVANRRVLTVESTIAAEKVDGVPQVSQRFRPGVLDLGDGVEASGEAPAETRELIGFRALYRYSPNHLYEHVYLSSTRYAWQCLVGEQFGHGDVDLATAYKIADNQYVFTFREFRIPVATTWLYDMDALRTTGAFFGLSGAGDIRNAPGGAFIIPLGRVSYPNEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K8</accession>
    <name>A0A7W7T2K8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="16621" checksum="C3C45F9519F6C233" modified="2021-06-02" version="1">MTRTTRHFAVALLLLIATACGTTRPERGRPASPVKSGTGELRTDLDPLTARFPLLAAAVKAEWMSGTLGDDRVPGPSTYWIDAVVTLPEATLAEIDRGTREDTTPPAVVEGLRDRLPGGPYLTGRSLDDAFTTATWSASAYRAKGTDVLVLVARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Q8</accession>
    <name>A0A7W7T2Q8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCLP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045641">
        <property type="entry name" value="MmpI-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19307">
        <property type="entry name" value="PCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCLP" evidence="1">
        <location>
            <begin position="52"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33647" checksum="5E0FCC37BD332545" modified="2021-06-02" version="1">MNAALADGAARQLANATKTAAHLDTITPRWLVRLLTWLPVEAGIYRHNRVRQPEAVEVACPPRDESELPQTFVDYEPTPREYFLNPVSTVVDVHTRVSDLYSSPYSQIEEQIRLTVEIIKERQESELINNPEYGLLTNVAAGQRLSTFTGPPTPDDLDQLITKVWKEPAFFVTHPAGVAAFGRECTRRGVPPATVSLFGSQFITWRGLPIVPSDKVPLVDGKTSVLLLRVGQRRQGVVGLYQPGLTGERDLGLSVRFMGINRNAIASYLISLYCSLAVLTTDALAVLDNVETGRFHDYADTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3F3</accession>
    <name>A0A7W7T3F3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Malate synthase</fullName>
            <ecNumber evidence="2 7">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="PTHR42902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="Malate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="SSF51645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="525" mass="57845" checksum="7D5CADB382247B0D" modified="2021-06-02" version="1">MSREEAAVPDRIVVTGAPGERFEEILTPEALDFVVRLDDRFAGRRAELLAARAERREVFAAGGTPDFLAETAAVRADDSWRVAPPAPGLVDRRVEITGPPDRRMAVNALNSGAKVWMADFEDATAPTWHNVVDGQLTLLDAIERRIDFTADTGKRYALADEVATIVVRPRGWHLVEKHVVVDGRPVSASLFDFGLYLFHGGRRQLAHGLGPYFYLPKLEGHREARLWNDVFGFAQDELGIPRGTIRATVLIETITAAFEMEEILYELREHGAGLNAGRWDYIFSVIKNFGDRPEFVLPDRAGVTMTVPFMRAYTELLVRTCHRRGAYAIGGMAAFIPSRDAETNAIVLDKVREDKKREAEDGFDGSWVAHPGLVGVCAAAFDRPDQLDRLRPDVVVTAADLLAVDRTPGGVTEAGLRGNVSVAVRYFGSWLDGVGAASIGGLMEDAATAEIARCQIWQWLRHITPLAEGGMVTEELVHALLDRELAAVRPERREAVRELFTATALAEDPPRFFTTGAYAGHLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3X6</accession>
    <name>A0A7W7T3X6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17623" checksum="B72EE8EC6B4B0BDD" modified="2021-06-02" version="1">MTAIHQPTTVAHVVAVTDPRAEPLLRELAFEYLTRYGTADELTGTDDAEFTAPNGALVLLEVDQEVVAGGGFRRLDEDTAELKRVWTHSAHRRRGHARQVLGELEELARERGYSRLHLTTGPRQPEANALYLTSGFRALFDVTADAEKIGVLRFEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T448</accession>
    <name>A0A7W7T448_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="46"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="31879" checksum="0583811DADFFAD57" modified="2021-06-02" version="1">MNHTKTTFDSAGVELIGNLYRPEGVESAPGVVVAGTWTSVKELMADRYAQQLAERGFTALSFDFTGYGESGGEPRDVESPALKVRDIHNAVTFLASHSWVDSERVGALGICAAAMYMSANAVDDRRVRSLALVAPWLHDRAIVEASYGGADGVAAKIAAAHRARAHYDETGEVEYVPVVSGTDVSAAMPFEIDFYLNPERGGIPAWPNRYAVQAWEEWLTYDAVALAPDIAQPTLIVHSEDAAIPEGTQRFYAGLPGRKDILWTQGTQFDFYDQAPQVNLAADTVAAHFRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I6</accession>
    <name>A0A7W7T4I6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein YeaQ/YmgE (Transglycosylase-associated protein family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9042" checksum="776F180DDF4874F4" modified="2021-06-02" version="1">MGILGWIILGLIAGAIAKAITPGRDPGGILVTMLLGIVGAVLGGFLGSALLGVGLGGFFSLSTWLLAIVGSVIVLAIYHLVRSRGHRAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W4</accession>
    <name>A0A7W7T4W4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15790" checksum="A58E3E53C128DF02" modified="2021-06-02" version="1">MNDWTTDPISYVDSSVFAPDNGERWAREHWLNVPGPFYPGETDTCRTGRLSAPRHVLYGGEFPNEFVHRQPRTRDEVDRVVEAAACEVGRVRLRRRRAVDAGRLCRLVGRTGRGRGAHRGTDRDVAGGVPRVHAGDGGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F5</accession>
    <name>A0A7W7T5F5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6587" checksum="2E6323A39527EF2A" modified="2021-06-02" version="1">MRLLLWIALTGALAVVGAMTLPLLAGVLLIACSDTHHCARRRRRQSRPGHNPTPAGYPLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I2</accession>
    <name>A0A7W7T5I2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with FMN-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030647397" evidence="1">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13732" checksum="E079526DB30BCC26" modified="2021-06-02" version="1">MRSSRRIVLFVLGTVTALVLLFGYPTSTSGAKDVVVSAPAGGGVTGPVVQTRWGPVQVRVTLEDGRITAVDVLQYPDENSKDEQINARALPILVDATLDAQSADIDMVTGATVTSEGYVESLQGALDEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K8</accession>
    <name>A0A7W7T5K8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">F4559_004325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22503" checksum="C41A488A3B8D6130" modified="2021-06-02" version="1">MAQLLRVDASIRRSASVSRAVADTFQRAWSARHPSGVVTVNDLETDPLPYLTVDDVAVNWTPPEGRTPAQHASAATAAGLVDELTAADVLLLAVPLYNWGTPALFKSWVDHVLNESRVAGRRGAFAGLPTVVVSARGGAYGVGAPREGWDHAVPYLRHVLGEQLGFDLHEVLVEFTLSDVDPGLAPFQEDARRSLAEAHVAAERLAKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M3</accession>
    <name>A0A7W7T5M3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized LabA/DUF88 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN_MARF1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="29713" checksum="A73948223B4720FF" modified="2021-06-02" version="1">MGNDERIGVFYDGTWFAYVSDYYASVHPRAARVSLDGFHDALRWYVHTVTGRPLAECVVSEAHYVRGRIETPAVAFDAVLAAAGVVRHDLPLHGGKEKGVDVHLALEAWVRATSVPLRWVVLVTGDADFTPLAARLVAHGVRVVLPVVDGGLLAPAWMPRTAAPLRAAASATPAFEDLFAPADRADYPLRAPFVRTSGGWASAAGEPRGRRQGTVTGWKPGQAHGFITDIRGASWFVSGDDLPEGSKSLPVGTSVSFSGPSTPPVGHRYPRAYAVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V3</accession>
    <name>A0A7W7T5V3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN family beta-propeller protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030829335" evidence="1">
        <location>
            <begin position="29"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="43232" checksum="C9A6282E06E11588" modified="2021-06-02" version="1">MVGQLRAVTGAVTLGAALLLVPTGTASAAPARVLGYVANNGGGVSVLDTSSNAIGATLTDSGGNSPYGVGVAFDGARGYVTNVRDNTLTIIDTPTNTIDATVQVGDGPAGVVVSPSGGFVYVSNYRAGTVSVVDAATATTTETIAVGANADGVALTPDGKKLYVAHDVAGPGTVTVVDTTTNTVVTDIATGNTPTAVAVTPDGRKLLVVNKFSDNVAVVDTASNAVVGTIPVSFVPHGVAISPDGSRAYVTNSENDSVSVLDVNGLKSLGVVAVGDRPISVALTPDGARAYVTNFTSGSVSIVDTAKLAVVGTVPVGVNPVGIAIHAVPAAPTKVVAGLPSSLVLRVNGMTVRGLNATLTESHTGRPVVGKQVTFLSVKGHPLCTAVTNSAGKAQCDATVRYLVGFSTLLRGYTAGFAGDLLHAAVSTHGFIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T644</accession>
    <name>A0A7W7T644_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2039"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2118"/>
            <end position="2192"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2196"/>
            <end position="2270"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2274"/>
            <end position="2348"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1038"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2074"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2153"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2231"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="2309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2819" mass="305068" checksum="5516A57DC443DEDF" modified="2021-06-02" version="1">MTTSEIEAGRAELLRRRLEQGRSAKRAVIPRADRSGDLPLSYGQQQMWFLGRLDPGSAEYLIPVALRIKGALDVDALRAAWAGIVSRHEVLRTRYALVDDKAVQVVDEPGVIDLPVHDVDGNPVAVLDHVDRAARTGFDLEREWPVRAELIRVADDSHVFVAVFHHIAWDAWSFGVFADELREGYGAAVEKLPPAVAPPAVQFADYASWERERSEVAHRRHLDYWGKQLVDLEPLDLPTDRQRPAARDWRGAVHGQSVPEATAQGVRELAKRYGVTEFVVLLSAFQALLSRYTGRTDVAVGTMVSGRTRPELQRLIGYGINSLVVRTRWTPATTFAELLGDTRTAVYEAFDHQEVPFARLVDELQPQRDMSRTPLFQVAFTLHEAQDDLFALPGLEVSPLDLPSQVSRFDLTALVKQSRDGALRLELEYATALFDRTTVERLAGHYLGLLDAVIAASESRVSELEFVDAAERDLLVRSEVDLSFTVDQGVHALFAARAAAAPTSPAVVFGDEVLSYGELNARANRLARHLVSVGVTPGSLVGICLPRSADVLVSILGVLKAGAAYLPLDPAVPVDRLRFMVEDAGTTVVITDAATRDVVAEFSEGTRVVHGDPAIAAHEESDVDLGTGADDPIYVIYTSGSTGRPKGVCLTHRNVARLLYAGHRHYAFSPDDVWPLFHSYAFDVSVWEMWGALLYGGKLVVVPQSVTRSPEDFLDLLLEHDVTVLNQTPSAFKGLVNLAEADDPRLDALRLRAVVFAGEKLEMGELRPWVDRFGTAGPKLLNMYGITETTVHTTYYEVTAADVADGWRNPVGVPLADLRVHLYDPNGNLVPVGVPGEIHVGGPGVASGYLNRPALTAERFVPDPFVAGQRLYRSGDLARRNPDGSLEFLGRIDDQVKVRGFRIELGEIEAVLTSSPGVLDGAVLLREDVPGDRRIVGYVVPEAGAQPSPREVREFIGARLPEYMVPAAIVVLERLPLTNNGKLDKRALPAPTDDALAKAAYLPPEGPTQERIASLFGDLLNIDRVGAGDSFFDLGGNSMTAVALVGRLRAAGVDVAVRDVFENRSVAALSALVDTREERVFDRRVQPFELISDTDRARLPEGVVDAYPLSKIQTGMVVEMLTSGERAAYHNATSFRVRDDAPFDADALREAARVISSRHQVLRTSIDIDGYSVPMQIVHEDAAMGVEHFDVRGLDDEGVDAAVREFVAHERANPFDLAEKSLVRIGAHEADGNVWWFTITECHAVIEGWTHHTLLMDVLDCYRQIRDTGAPAAVEVPDLRYADFIAAELASLDSPDDRAYWGSVVDTYPRFAVPTGWGDPSVEPHTVTHAVPFVDLEPKLRDLAASAGASLKSVVLAAHFTVLSRLTEQESFLSGLVLHGRPEVLGAERVYGMFLNSLPFHHDRTARTWRDLVGAVFAQEAEVWPHRRFPMPVIQQELGGGERLLDVRFSFHDFTMVDRELVDYAASIDDSPTEFPLAVLARLGHVFLMANSAHFDRANVERIGALYREVFTAMAADPQGDPRVVPLPEAERRSVLAQPDVVVEGFAGSVLDGFEAQAARTPDAVAITYKGESTTYAELDRAANRLAHHLRDQGVGTESVVAVLVDRGPALMTALLATWKAGGAYVPLDPSYPVERVEAVVTDSGAVVAVTESKHTVPGVPTVLLDREAFADRPDTKPDVAVDEENLAYVIFTSGSTGRPKGVQISHRGLANHVRWAADELAGEGGAPVFSSVAFDLVVPNLYAPLVTGHRVAFLPQDLDLADLGALLLEAGPFGFIKLTPGHLDVIASQVPAGTHLADVLVVAGEPLTRTTVRRWQELSPDCRLINEYGPTEASVGTSIHPIHGTPTVDVLPIGKPLPGLTMYVLDARMHPVPIGVVGELYVGGTGVARGYAGQPAMTAERFLPNPFGPGRLYKSGDRVRRAADGTVEFLGRVDDQVKIRGYRVEPGEVRNVLLDHPSVSDAAVIADGTGNDVRLLGYVVSDVDGEELRRFCATRVPEYMVPAAVVRLTAIPLNANGKIDRRALPSVEEAAAEVRSSEPRTALERQIAEVWCKVLERSSVGVHDDFFAVGGHSIRAVAVVGALRAAGVEVGVQEVFRNRTIAELAEAISGVPVQEDAPRTPLETQIAEVWCRVLDLPSVGVHDDFFAVGGHSIRAVAVVGALRAAGVEVGVQDVFRHRTIAELAEAISGVPAVGGPRTPLEAQIAEVWRKVLDLPSVGIHDDFFAVGGHSIRAVAVVGALRAAGVEVGVQDVFRNRTIAELAEAISGAPAVGGPRTALETQIAEVWRKVLELPSVGVHDDFFAVGGHSIRAVAVVGALRAAGITVGVQDVFRHRTIAELAEAISGESAETVPGERLVEPFALLSAEDRAALPGGLADAYPLSRVQLGMVVEMLSDPTVNRYHNCQSFRVNDTTPFDVDALRRAAAKLVARHEVLRSAIHLEDYSTPLQLVHEHAELSVSARDLRDLDQAGKENAMREFVAHERATLFDLRTAPLERITVHVDGDDGWWLSVTVCHAITEGWSQRLVVGELLALYRAERDGGDAGLPALPAVRYADFIAAEQKSLASEETAEYWTSVVTGLPKFTLPEAWAGAPGASYILPVAFADLRTDLERLGAAAGAPFKSVLLGAHLAVLSRLGADGGFHSGLVSDSRPAVEGVERVPGMYLNTVPIAFEGRATTWRELVSGVFETETALWPHRTLPMPAIAALAGPGRLLDVMFSYRDFDAAETDLDGQSGQGGIGVGEGAGEGANEFPLAVSTVPGHLALTVDPSYVAPEHGRWLADLYRRVLEAMAADPDGDATAELAADDVPDWNDTAVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T659</accession>
    <name>A0A7W7T659_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14875" checksum="A97BFC504450B2CE" modified="2021-06-02" version="1">MATWNDVRDLVFALPGTTERPTMDDMTAWRVADKLLVWDRPLRRGDLEALGDDAPDGPVLAARVADFGIKEALLADSPDVYFTTPHFDRSAIVLVRLENIGVDDLEELITDAWVGRAPKKLLRQWESDQAAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T670</accession>
    <name>A0A7W7T670_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="454" mass="48315" checksum="AB11CB241969A7E6" modified="2021-06-02" version="1">MTTRAVVLGGGVAGLLAAAALAHHVDTVTVVERDRVDSGPRPGVPQGRHAHLLLDRGFRAVVDLLPGVDAALKTAGARRLRMPYDVLTRTPSGWLPRVEHDRYLVACRRPTLETVLRHQVLLVGEVKLMTGADAVGLVGDADRVTAALVRDRDTGETRPLPADVVVDATGVSSRADRWLVDLGLPPVREVEVDAGIRYATGEFRAPFGDDFPAVVVQSDPNGPACGGVVLPVDDDRWLVSLAGLRGRVPPTDLDGFTAFAAGMRHPIIADLIAASRPLGTLRGYGAPPARLRHYDRVARWPEGFVVVGDAVATFNPVYGHGMTVAALDAVALRDNLRDHGPDTRTARRAIARVTAPAWALATGQDLRYPGTFAPPRTLGDRVGAWYADRLGAAAVVDPDLALAMLDAYTLNAPLGGLLRPAVLGHVMSAVLTGRPADEPPLTDQERESFSSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6F1</accession>
    <name>A0A7W7T6F1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="225"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="531"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="885"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1452" mass="157847" checksum="90F1D74E9B3AB2CD" modified="2021-06-02" version="1">MVSADRPVPKPGPPPAPQRWFQERTSPYPWEQDGLDHIRRLMPNVEPHRAWATFSFTAASGRINECDLLVAVPGGLYLVELKGHPGRVVNNGETWSFYHEDTRRPRTLSNPLHLTDLKSKELKARLAWAAKQLGLRDRVPRVEPIVFLSAPGLESTLDEVQRTRVYGRDDNSTGLPWIWRDLLGRPPQRESQRIKPEFSRRLPDLLKKIGIRASTAHLRFGDDWTLTPDPLDAGPTWEDRLAERTGIVQEEGRVRIYLTAQQATEEARQSVERAARREYQVLQGITHRGIAQAMEIREHQGGPAIRFRHRATDLRLDAYLALYDATLTPEVRLDLVRQLGEAVRYAHSRSLYHRALAARSVYVSAKDDGSSPVLRIIDWQSAARDFDTTGMSSILTSTGGRHIGDIASGFLAPEFDTPYADPVDLDVFGLGALAYLIVTGQQPATTRGALVERLRSEGGLHPYAVTDSVSDALDELVFRATRADVADRLDSADAFLDGLNLVEQDSPTPEPTGGGVDPLEALPGQPLDGDWVVERVLGTGATAKALLVIRSTEADDDRSRPDKRVVKIALDEEKAERLRAEARALELVGGGVVVRLLDGPRTLGGRTVLDLEFAGDRSLGALLRAEGRVVYHELERFGNDLFTALDQLAAKGVRHRDLKPDNFGVFERADGTRQLVLFDFSLHGVSERDVKAGTRGYLDPFLDTARRPVFDDHAERYAAAVTLHEMASAQRPVWGDGMTDPRTATDETPTIAADLFEPALRDGLVDFFLRAFHSDVDRRFDTLQQTHEAWRSIFAGADAARPVTTPATVDMGTGDAEETRDAHVRAADRDTPLEAAGLTPRAVSVAQTFGASTVGELLDVPLHQIAKARGAGAVIRKELNRRHKQWTAALRRPAERSSSRTPKDSPEEQAGLATPGLLTVDDMADLLTPSADRKRSSKADAVRLTLGLPDASGVPQSWPTQGEVARRLGITQASVSRHQSAAAKEWAAATWLDAVRDELVDAVVAAGRVMTAHELAAALRARHGATGENPELAAAKASAVVRAAVEAEVWAGMNSGDEDAGPRLAVLRRGARVLVACESLVGTDDPSAPELADYAQALGKQADDLASRDPLPGRGVVLRELRAVTPPDGLAPLADTRLVALAAAASGHAAGSPRLELYPRELDLAKAFRIAQAGAGVRRDIGVTVDDVVSRVRARFPELVLPKPLTHVPIGEALRAAGFPLEYDTTAKRFQPPAPEYARVPSSTGTSVSAHARLVATGHDPAVLIRTKLTAAIERGGFVALTLRGGQLPGTAEAIIRDHPVRPVDLDREFLDELRALVAERGQDWEKVLSVDARFAESGEMSPGLASYVRATWTRVADHLLDPANSADAVLFVHNAGLLARYFDEGGHDLLTRLQNAARRPADAPRGLWLLCPGESALDTAQLDGRTVEVLGDSERVALTSTFLVGLRGDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I4</accession>
    <name>A0A7W7T6I4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="140"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="383" mass="42040" checksum="EB6E2682BC879244" modified="2021-06-02" version="1">MTNRRLPAGSWLPVGRLPGIPAALCAEGAYLPRPLPSTLDFPVATYRRAADAMLLLGRLDEAATRSPVRSTLVRATRVRDARSSANLAGIVLGLTEAFAEELLVSQGEGPLPRTGHSRLVTPFLAAYRYGLDRVGAGEPVDDTMIGGVSAIMTGAPGPRRRTGVGWLGRKPERAYLLTASGAHLAASVEQWSTTAREISDQPVILKIGLLHYQLEVLQPFPTANGHVARTYSMLAMVESGLLRDQVLPLSVWLNDSLDEYQRQIRRVVDTGEVHHWLDFYTTAIRDQAYDQLGLIAALDGLIAEFRRLVSGDTVYAKVAEDLVGFPVTNHRAIQERYGVTRKFSTDVTRRLVDLGILSSWEGRGYRQVFVCDPVLDLLTLYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S4</accession>
    <name>A0A7W7T6S4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of protease activity HflC (Stomatin/prohibitin superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22967" checksum="BCC8A59B2471C439" modified="2021-06-02" version="1">MKHTFLPWERGVHFRRGVIVGELGPGEHRLRRDDVVKRVDVRAKNHVGAWQDIPTADGVLVRVTSVLKWMITDAVRYLSVSADPVQDLHLAAQLALRAAVLTRPHDRVEPERAAIGAEVLAALGDPVTGLGLVVEKVDVRDVIMPAELRKAALAEIVARAEGRAALERARGETAAVRSLLNAARLAEEHPALLQLRALQSAGTVVVDGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T3</accession>
    <name>A0A7W7T6T3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="35454" checksum="77717BD6435AB4AE" modified="2021-06-02" version="1">MDHTRLDGPGDVIAAVPHLLGFHPSDSIVLLALEDSRVHATIRTDLGEPRHDPALAHRLVGPVARFGVDSALAVVVGGCGADPPERLPRDSLIGHLTHLLTHVDVTLSHALWTRSTHDDQPWFDYHDRGTAGRVPDPRSSAFAAESAVRGHVTYRARAELATLLAPDPQDALTRRARLLDEYTRLRDPDTRARDHDLVRAEIVRAADRTRPLTDEEVADLAYALSDPYVRDGALAHAVGPHARGAELLWTELTRATPIPERAEPATLLAVSAYLRGEGALANVALDQATTADPTHRLATLVGLALEAGMSPLELRSLAENAGDRHPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X8</accession>
    <name>A0A7W7T6X8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="32198" checksum="FBE85EB543A0BC10" modified="2021-06-02" version="1">MTSVVERLRRDSPGFSVEFFPARDDADEAVLWRAIRELEPLDPSFVSITYGAGGSSRDRTIRTTARIAQETTLVATAHLTAVQHSVAELRNVIGWYAAVGVRNILALRGDPPGDPYGEWTPQPDGLTYAEELVRLCRELGDFCVGVSASTYGHPRSPDLDTDTKHLVSKIRAGADYVIAQLFFRPEDFLRLRDRLDAAGCGDVPLLPGLMPLTTKRTLAKTVELSGADVPDEVSRRLDPYLDDPAAFRSAGIDLATETGARLLAEGVPGLHFYTLNRSKATREVVGRLGLVPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y5</accession>
    <name>A0A7W7T6Y5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13331" checksum="D6EC2EA66A9331F4" modified="2021-06-02" version="1">MAAQRVLVAEDDPDIGLLIDFKLAQAGLDVITVADGAVVLDRARATEPDLFLLDVHLPGRSGLELCADLRQDPITRDKPIMLLSGGAHQWEIDEGLAAGANEYLVKPFSPAKLLEHVQNLLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H1</accession>
    <name>A0A7W7T7H1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="559" mass="57991" checksum="78E185C3B94A1E01" modified="2021-06-02" version="1">MSNPLVVARQDSTTDYTGIGIVEAAVDLDRALNGGTWVEQAIGGAAYGLETLSAALDPLGTLVQYAISWIIEHVAPLRDALNWLAGDADQIAAYAGTWRNVAQAVDRARQDFVTEVANGTAGWTGSTADAYRASASAQAEHLAGAARCSGIVGTIVQTSGALVGMVRGLVRDLIAACVATLVARIPQWLAEEAVTLGFATPHVVASVVAIISSWVAKIADKITLLLRSIAKLRPLLGRLDELWNLIKQGVRNLRRPSSATPHAPPAPVRTPSTTPVTPHGGTTTTPSAAPTGGAPVSTPPTVHGTGTTTPSGATVPSGSPVSTPPVVHGSGTTTPSGTTTPSGTPVTPPPTVHSGTTTPSGATTPPTTPVSSGGSGPKIIRRDDDFPNPISPKGLRKSHLDEHGNLVPANPKGDTKPWQHVLGGKNKVAKENSPYTSFSVQGADAKLYGNKEIHLDHERLQADIDSGKLKGVEILPPAKVEASLQGEVDRIAGRPVEITLPNDATPDQVRAFAEGLGLSKGKLDSFTGRVQGILNSRRDGEWLIKGVVPAEYVHGPYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K8</accession>
    <name>A0A7W7T7K8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="135"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="487" mass="53257" checksum="305199A448C924B7" modified="2021-06-02" version="1">MPAPVTVKPRPGTTFTLGADTTVHTHPGSPEARRVGEYLAGVLRPSTGYRLPVVPGASGRDISLVLTGADPAVGEEGYQLDVTTRGVIIRARTAAGLFAGVQTFRQLLPAKAESGTKQDGPWTVPGGSVVDHPRYAHRGAMLDVARHFFPPDEVKRYIDRIAAYKINKLHLHLTDDQGWRLEIKSRPNLTAAGSTTQVGGGTGGFYTQDEYRDLVEYAAERFITVIPEIDLPGHTNAALVAYPELNEDGIAREPYTGIDVGFSSVAIHKDETYEFLDDVLREVAALTPGEFIHIGGDEALKTTDEDYLAFMGRLLPLVAKYGKKALGWHEFLKATPDASAVAQWWGTEPKAPELVEAAKRGNKVILSPATKSYLDMKYREDTELGLKWAGFVEVEQSYSWDPGAFVADLPADAVLGVEAPLWTETVEDRAALEYLVYPRLAGIAELAWSPASALGWDGYKERLAAQAPRWRAQGIAFYESPQVAWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7M3</accession>
    <name>A0A7W7T7M3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030842998" evidence="7">
        <location>
            <begin position="28"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="8">
        <location>
            <begin position="165"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="576" mass="59903" checksum="06671895077FE495" modified="2021-06-02" version="1">MRTGRTVPAALAVAAALVVATGQPALAVERTDYTVLVEDGASRDAAVAAIAAAGGEVTRENKAVGLLTVTAPKTGFAQRVSASDAVLGAAAVRPLGSAAPGRGKSNRDMRVVERENEATAGVPGTAAKKKPSPTPAAGLDPLDDKLWGLKLVRSDLARDRQPGDKRVSVGILDTGIDGSHPDIAPNFDKARSRNFTVDLPTDEAGNEVDGPCEFRGCVDPADWDDDGHGTHVAGTIGAAANGFGVSGVAPGVTLVNIRGGQDSGYFFLQPVVDALTYGADIGLDVINMSFYVDPWYYNCAANPADSPEAQLTQRTAIAAVTRAINYAHRKGVTLVAAGGNNHEDLGNPRPDATSPNFPTGAAYPRTIDNKSCVHLPTESDHVLAISSLGPSGLKADYSNYGTEQTDLSAPGGYFRDYFGTDRYRTNENSIRSTYPRNVALAAGAIDAAGNVTPAGEAAGVAKYCQGATCGYYQYLQGTSMAAPHASGVAALVVSQYGRKDRAHPGTLTLDPDKVAKVLVKTATQRPCPTPRTVSYENVGRSPEFTATCVGDTRFNGFYGHGIVDAFGAVTRGGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z2</accession>
    <name>A0A7W7T7Z2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="20102" checksum="EF437B67F6FD6788" modified="2021-06-02" version="1">MPEPHVEVRRSARRRRMVSAYREGDKVVVLLPARMTKTEEKHWVAEMLSRLQHSETRRRSPTRTSDAALLARCEDLSARYLDGVEPRSVRWVPPMRTRWASCTPSEGTIRISERLRDVPAWVLDYVLVHELAHLRVPGHGKDFWALVHRYPKAERAIGYLEGLSAAAGLGITEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G9</accession>
    <name>A0A7W7T8G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II/3-oxoacyl-(Acyl-carrier-protein) synthase/NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="480"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1568"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7">
        <location>
            <position position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1647" mass="172092" checksum="421256A897D759D3" modified="2021-06-02" version="1">MPDLSPVAAARRFSGGTAVRCGAVVLGYPELVRRAGRLAARLGEPGGRVAYLGGNSPELLITYLACAWHGSTFVPVNPRLSVAEADAVLRHCGAHAAVVEPGHPHAALDVRRVTGEGEPGKPVACAPDDLAMLLYTSGTTGRPKGVRLTYGNLHANGEGFGSVADTRPDDVNLVVTPLAHIGGLNCFTLRSLRRGGTTVLHRSFDPARVLRDLVAHRVNTMFAVPSMYAAIARVPGFADADLSALRVPIVSGAPVPPALIRLYAEHGVALQQAWGLTETSCYATYLPGADRIGSAGKPLPHNEIRLVDPDTGTPGPRGEVRVRGAGVTAGYWAEDPATGFDAEGWLRTGDVGVLDDDGYLYLVDRLRHLIITGGENVYPAEVEHALADCPGLVEVAVLGVPDAVRGEAVLAVVVGGGLTLAVVRRHASGRIADFKLPTRLRVVAALPRSPTGKVDRAALRDLVVDVRSTPPGFPHPVSAPGAATSPGRVLSADASSILDGFDPHTPFADLGVDSLGAIALRDRLAAATGLDLPSTLVYDHPMAAAVRDFLDGVEVSDGPGPDLVAEPIAIVGLAVRLPGGIDTPEALRDLVLSGGDVISGFPADRCWPGAGFGGFLDGAAEFDAEFFGIPDHEALATDPQQRVLLEVTWEAIERAGIDPRSLRDKDVGVFTGVFANDYAHRVPPDGHRATGGFAAMAAGRVSYVLGTTGPALVVDTACSSSLVALHLAVRSLRDGECSLALAGGVTVMTSPHGFVEFAKLGALAPDGRCRPFGPDAAGTVWSEGVGVLVLRRLSDAVAAGNPVLAVVRGTAVNSDGTSNGLTAPSGRAQRRVIRRALADAGLKPSEVDYVEAHGTGTVLGDRVEAAALADVYGDVAIGSVKAHVGHTQAAAGVVGVVNALLADGPRRVAVSSFGLSGGNAHVLLEHHDPALPGPARTSFRRKRFWLDPPSTGHPMVTAAVDDPETGGVLVAGSWSTAEHPWLLDHVVDGTPVLPGTVWLDVVAYAGALVGCPVVADLTVDRPLSPGGTFRVKVGAEHDGRRPVAVYAGSCRATGHVTSTVASPRPVAWPPDARPVPVDDFYTDREWGPAFRCLRAAWRGDDLFAEVALPAADPRYALHPALVDAALHAALLDDQGPVIPFAWEGVVRHGSASTLRVRLSRVDGGWSLAACDTEGRPVLSVTRMRTASAPVHVLAWRPTSGRADSTGWYVLRPERAEGLPAPERARVVVNRVRRDLLAFLRRHPTGRLVVNTRDAVAVRPDEEVDPVAAAVWGLVRCAQAEYPDRFVLVDGPPGEVADEEQCAVRGDAVFVPRLVPARTESTRTGSSRYGRTALITGGTGALGAVVARYLVSQGVTNLVLCSRRGREAPGAVELCAELREAGAWVDVVPCDVGDREAVRDLLDGLERAPDLVVHAAGVLADGAVDRTTPDRVDAVFRAKVDGAVWLSEFLPDAALVLFSSVAGVLGTPGQAAHAAACAFLDGLATRRPGVTSLAWGDWGGAEPAFAARAGVRPVDTGTALRLLCADAPAVLVPAVFDTGPLDRVPTPLRDLVPARRADLPSRVAALEPRDRSAFLVDVVLREASVLVARVTADRAFHDSGFDSLTAVALRDRLAAATGLALSPALVYEHPTPEALARHLLSRLEGECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J0</accession>
    <name>A0A7W7T8J0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
            <ecNumber evidence="3">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="34307" checksum="2B4CFDD63053C8CE" modified="2021-06-02" version="1">MTSVDTIAADGKAVLDAVGTVVVGRQRSLRLALAAILAGGHVLFEDVPGLGKTLMARSLAQALRLDFKRLQCTPDLLPADVTGSFLYNPGDRDFTFRPGPLFTGLLLADEINRTPPKTQSALLEAMQERQVTVEGRTFPLPRPFHVLATANPVEYEGTYPLPEAQLDRFLLRLDVGYPPADEEVEVLRRRLARQQEDAEVAPVLDADRLLALQRGVETVSVDPDVLRYCVDLASATRSHPAVEVGASPRGALALVLVSRALAVLDGRDFVLPEDVKECAVPALAHRLTLRPETWTSGTTGVEVVDGLLGGVPGPASSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K7</accession>
    <name>A0A7W7T8K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15289" checksum="040A719F4115B5CC" modified="2021-06-02" version="1">MAVQAGPPEGRYGRPRRPLPRWARWSLPVVGVLVGGVVAWVGYRNLGTAPVEAKQTAFQVLDDSSVAVTFEVFRQTPDRPVVCIVRARADDGDEAGRREVLVPAGAETVRPKTVVRTSKRPTTGEVFGCSYQVPPYLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Q1</accession>
    <name>A0A7W7T8Q1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="31288" checksum="5CEA1B2ABD3AA9B5" modified="2021-06-02" version="1">MTGRPWPDFRPGPLGAVGAWFRRRKDRPAPEEFTFVPAQSSHEYPFETPLPSAVHGLDFRASFTVCWRLDMHSNARHNAPRSAAVNDLVRRARALTERAMLVHHAPLRHQLGDELSAERQVEGTHVWARAEDVELTVDPGDLEMARKHVELHQALTVREAERDAERAEIRYLRDEVLTDLSTATIWWLYRNGYQVEQAVALAEQLAALVRIASERRDAHWADTLVTSFESALPTLSDGHRQDLRLHLAKALGVYGGSSVAGEFAEQVGLPHGNGAKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T936</accession>
    <name>A0A7W7T936_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="31"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="478" mass="48620" checksum="FABCD951106109C6" modified="2021-06-02" version="1">MSPHRLAAGVLLPGFHGTTAPDWLLARLADGLGGVVYFGRNVVDDAQVTALSAQLRAVRADVVIGIDEEGGDVTRLDYGRGSEVPGNHALGAAGDPDLTRAVAASVGARLAACGVSLNLAPSADLVLTLDDPVIGVRSFGSDPMAAGVHVAAYVEGMQAVGVAACAKHFPGHGASTVDSHAALPVLPRTVAELAAVEFVPFRSAVAAGVRSIMTGHLVVPEWGAEPATLNPVAVRVLREQLGFTGAIVTDGLDMKAVGGDLAAGAVRSLVAGADALCLGGEPLDDAGLQWLIDSIVAAVESGTLPLERLAEAARRTAALGVPPARVEAHDASLGSEAARRAVEVRGTLALSGPPVVLDLEVEASIAVGDVPWGLGPYLTELIPGTTVVSARTADEVAAVAAGRTVVVVTREAHRFPFTRDLVSSLAKIGLDLVHVETGVPGPDLGTVARVDTHGGSRVCLRAAAERIAASQRLEQGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T974</accession>
    <name>A0A7W7T974_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucosamine--fructose-6-phosphate aminotransferase (Isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="196"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="35844" checksum="C1047372B5F2AD97" modified="2021-06-02" version="1">MTDHQPGGHMAAEIAQQPKIFADLVARRDQIAAVADVIRERKPRFVLFGARGSSDHAALYAKYLTEVLLELPAGLVSPSTTTLYGAQPDLRDVLLVSVSQSGGSPDLLEVTQSARERGALTVAVTNTASSPLNAAAELSVDIGAGVEQAVAATKTYSATLLALYLLVDAIRGGDGRAAAPLGDLAQSTLDGSVDAVSEAVQRYRFVDRVLTTGRGYSLPTALESALKLAETSYLAARAYSGADLLHGPVAAVDGETAVLAVTSKGRGGDALHDVLDVVHGRGADVVAVGSAASAVSAALRIPVPETPEEVAPILEILPVQRLAHGLALARGGDPDNPRGLKKVTQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F1</accession>
    <name>A0A7W7T9F1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconokinase</fullName>
            <ecNumber evidence="4">2.7.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="245"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="466" mass="49062" checksum="EA34790B001C63EA" modified="2021-06-02" version="1">MADVVLAIDQGTTATKVSAVDRHAHVLVSAERSHPVRTTPAGEATHDPGEVVDAALDALREVAAAGHHVHALALTGAMHTLLGVDGAGRPVTPSLSWADNRAKDQAQALRDTDLGRRLHRETGTPVHPFAPLAKLAWAGANKITADRWYGLKDHLFRALTGEVATEHSSASGTGLLESATLDWHPDALDFAGIDPEKLPDLRSPLDSAPLTRHVPGVPRDVPVVLGGGDGPLANLGVGATTPGVAAVSLGTSGALRVARDAPIVDERGRTFCYYVAEGLWVVGGAVSNGGIVTQWAADTFGLPAADLLAEAALVPPGARGITALPYLLGERAPWWTSDARSALVGIRHDHGRAEITRALVEGVAQQLALVLDAVRSTADVRTARVTGGAFRSPLWTEVLASALDLDLEVATGDSAVGAALLAWRALEDRPPTPAHRPGRIFRPDKDIAELYRRGRQDVERLYLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9M5</accession>
    <name>A0A7W7T9M5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 17">Aspartokinase</fullName>
            <ecNumber evidence="7 17">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">F4559_006355</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 18">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7 17"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="12 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="267"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MBB4968996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="421" mass="44540" checksum="0F0B41CE993DA234" modified="2021-06-02" version="1">MALVVQKYGGSSVGDAERIKRVAERIVATRKAGNDVVVAVSAMGDTTDELLDLARQVSPVPPAREMDMLLTSGERISMSLLAMAITSLGAEARSYTGSQAGVITTSVHGKARIIDVTPSRIQDALSEGAIAIVAGFQGVSQDSKEITTLGRGGTDTTAVALAAALKADVCEIYTDVDGVFTADPRIVPNAKRLETITYEEMLEMAASGAKVLMLRCVEYARRYNVPVHVRSSFSNKPGTIVSGSVEDLPVEQAMITGVAHDRSEAKITVTAVPDHPGVAARIFRVVAQAELDIDMVVQNVSQAVSGRTDVTFTLPKDDGPRAVAVLEKAREEIGFDQVLYDEHVGKVSLVGAGMRSHPGVTAQFCEALASAGVNIEIISTSEIRISVICRDTQLDDAVRALHDAFELGGDEEAVVYAGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA41</accession>
    <name>A0A7W7TA41_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5730" checksum="2E58B97DA35AFFD3" modified="2021-06-02" version="1">MYGWIWRHLPGPLPVRILEALVLVAGVVALLMFVVFPWAEPKLPFNNVTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH5</accession>
    <name>A0A7W7TAH5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030802433" evidence="2">
        <location>
            <begin position="28"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="20158" checksum="C67C2B606DB9DCD2" modified="2021-06-02" version="1">MRRALPFLAAALVLTACAESTPGTPSAGSAPTTTASGSSQPSGSAKPSTSATPKKRPKTINIKDVDPCTLLTDAQRAKLGLGGTPTKQTDDEGYQECTVSREDHKYLTGMTVYPDRGVEYYSGGAKTPEPIEIAGFPALKMASSMPLGDSCAVVVDVSDGQVVSSDVMAFGALKGDAVCEPTLKTVTEVVATLVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAP0</accession>
    <name>A0A7W7TAP0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="653" mass="69559" checksum="A717451CC79F0150" modified="2021-06-02" version="1">MAEASPLLTAGTIAVYLAVLFVPGGLVALAAGLRGWLLAAVAPVFTYLIAGLAGPWLSKIGIRFDVLTFVVSTVVIALLFLAARLVAVRLRGRGEPDTSPWAPGGHAAVVLAVVVGAGVGIFVLLKAMDFDLGVVPQDWDAGYHANGIRYIADTGDGSLYGTGKVNWYDVPTGVFYPNAYHLVGALVFKLTGATVPAVVNAHMALLPGLLVFELAAMVRHFRGRAVTAVFTALVAAASTSATYDNLWRGPLLTFTLGLALMPVLVVVVDRYLRRPGLDTGAAFAGVAIGMLCVHSSNLFGGVLFVIPFLVQRWWRAPRVMLRDILWTVPPGLAAVLVTLPHLLGAASIKGTIAIVDWPSTFPVSQSVGSLLTFQHIIDRPQYWLALPLWVGLAFAWRLGNQRWLLGAAALFGAVWVLTASYAQPWVARVTSPWWNDQYRLIALACVPLIVVAGHGFAVLHDRLAGLARDASGRPPVRAASVAVVAAAFIGLSGMYVTLNAGQVARGYGNAPGQDKNDAVVSTGEVLAFHELAKVVQPGERVLNDRNDGTLWMYAIAGVQPIAGHYDGSLESPAIAMLEQHFVEYDENAAVRAAVKRLNVRYVILGQGFVRGWNERAGGLRGLEGKPFLTKIYENDNAVVYRLVPPPGEVVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAY7</accession>
    <name>A0A7W7TAY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator/MocR family aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="478" mass="51423" checksum="4E85E0C4B5EC9009" modified="2021-06-02" version="1">MATNWTTYRELLLPHPTGRRRAVESELRRAVRDGRLAPGTRLPSSRDLAAQLGVARGTVTSAYAQLVGEGYLVARRGSGTAVAAAVTWPDAPPADRPPEDAAPPRRWRYDLRPGLPALNAFPRDEWSQAHRTALAGLPADALGYPDPAGYAGLRAELADYLGRVRAVAARPSDVVVTDGAAEGLALVAKVLRDNGHRTVAVEDPCHFGSTALLSSHGLEAVRVPVDERGIRVDRLAATDCRAVLVTAAHQFPLGVVLHPERRRALLAWAHDRDGLVVEDDYDAEHRYDRPATGAMQALDPNRVVYQGSTSKVLAPALRLGWLVLPPVLHAAVVQRKRMNDLGTATLPQAALAHLMRSGGYDRHLRRTRQLYRARRDALLSALAEELPTWEPIGVAAGLHVVIRLPDGTDDVAVQGRLAGRGVNTLALADFAGTPTFPGLVLGYAATTPDRLRAAVRIMASVGTVGTSVRTPPLDSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB59</accession>
    <name>A0A7W7TB59_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxymethylpyrimidine pyrophosphatase-like HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="27900" checksum="3855D9F7B58D6108" modified="2021-06-02" version="1">MTWKPRLIALDIDGTLTREGTETISPAVRAAVGRAVDHGATVVLSTGRSLIGTTPIADDLGLRGTTAICSNGAVWWDTDSREVVHRDVFDTAPVLDVLRRELPGGVYASEVTGVGNIAVGTFPDGDLWGEVHQVDFAALAAHPTSRLVVRWLDRTPEQLALQLLDLDLPGVTPSIDHGVAWLTLTAPGVTKGSALERLRARLGVSESDTLAIGDGHNDEAMLRWAARGVAMGQAPATVHAVADAVTATVLEDGAALELDRWFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB69</accession>
    <name>A0A7W7TB69_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11093" checksum="D45C3BA645766DC1" modified="2021-06-02" version="1">MDGSDLGLDPVVHPLPRLSLCAALAAGPGWVEFAVVRETTGLSDSAVSKHSRALEGGGYVEIKKGAVGRKPRTWLRLTPMGRARLAGHVAALQRLAAPANVQVETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBU8</accession>
    <name>A0A7W7TBU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secretion/DNA translocation related CpaE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="353" mass="36513" checksum="90C8F8C1DEA8B3DD" modified="2021-06-02" version="1">MERPVVLMAESATTDEVLRLAAAVGCDLDRVADVTELRARWRTAPLVLLDTDAVEACAGEGFAHRSDVLLVANGPPPTPTAALRLGVQLVDLPSDTDELHALLADAADNPSPVRGRVLAVLGGRGGAGASVFAAAVAQEVLSSGGTGLLVDCDPFGGGLDLTLGAEGESGLRWPEVRVTGGRVRATALRAALPRRTAGTGSLTVLSCAREGTPTLTATAVGAVVDAGTRAGDTVVCDVPRHPTPPSTAVLDRADLVILLVPAEIRACAAARQLATHIRTRHPQARIRTVVRGPAPSGLTPHHVAEAVGVPLLTTMRPERHLPESLDQGHFPHRPRGPLSKAARLTLTALLTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTB4</accession>
    <name>A0A7W7WTB4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="12883" checksum="4700131CC18C6198" modified="2021-06-02" version="1">MSGVPELVGRFRADVGAAVTRARRAASEAGVRVAAQRAGNRTRGGGAATSGDVRRVATGFRVERGLPLGPVDLPESEESRKQTDTNANAEPPSRFRSAPGPRGRLPRESGDDEDFSQARILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR4</accession>
    <name>A0A7W7WTR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20947" checksum="6C116627621C4D11" modified="2021-06-02" version="1">MDTDAAEEPWDLVRAAQKGDTDAFGVLYDRYVDIVYRYVLFRVGDRTLAEDVTSETFLRALRGIGSISYQGRDVGAWFVTIARNIVFDHVKSSRYRLEVTTAELADNREVADGPEQEVLTDAANAELHRCVAQLGADQRECITLRFIQGLSVAETAARMGRNEGAIKALQHRAVRRLARMLPSWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX0</accession>
    <name>A0A7W7WTX0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6477" checksum="472FCA73E8338DD5" modified="2021-06-02" version="1">MHDVAVIDDPGAAEVPLDPVRARLPAGAVTALVSKYHDDAGRSHRIVVAVHPTVRREEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX9</accession>
    <name>A0A7W7WTX9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="269" mass="29535" checksum="994E81C1D186811C" modified="2021-06-02" version="1">MENEDLVIHMQGVSVRRGRTTLVGDVDWSVELDERWVILGPNGAGKTTLLRLAGAELHPTKGRLHLLNERVGRTDLMELRPRIGFSSAALANRVPAEEKVSDLVVSAGYAVLGRWREEYDKLDTGRAVELLDALGIAHLADRTYGTLSEGERKRTLIARALMTDPELLLLDEPAAGLDLGGREDLVARLSDLALDPDAPALVLVTHHVEEIPPGFTHALLLREGGVVAQGLLDDVLTEENLSKTFDQPLELQRSGDRWFARRKAAPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU36</accession>
    <name>A0A7W7WU36_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07474">
        <property type="entry name" value="Peptidases_S8_subtilisin_Vpr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034213">
        <property type="entry name" value="S8_Vpr-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031373658" evidence="5">
        <location>
            <begin position="17"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="173"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1094" mass="112670" checksum="6042BD9E0F9320F5" modified="2021-06-02" version="1">MAAILVVGSTAGTALAAEDQPAPSVATATGLDAGMVDTKVVDRLSTATGTVTAFVELEAKPAVDAYEEKADQGGTKQQAKDAAKASKAESGKVADSVVGDLKGKDGATRELYRTANGVPGVVVRADAEKLRELATRSDVKSIRTVVPKQRTNASAVQLTKTLNAWQSYGKLGDDTRMGIIDTGIDYTHADFAGPGTPEAYKAVDPTKVDPSFFPTAKVVGGYDFVGDAYDGESPDPEINTPKPDPNPLDCNDHGTHVAGTAAGFGVNADGSTFKGDYTKLTPEALNAMRIGPGTAPKALLYGLKVFGCTGSTNVTSLALDWSLDPDGDGDFSDHLDVVNLSLGSDYGAPDDPDSLFVRKLNKAGVLTVFSAGNGGDLYDIGGSPGSTPEALTVASTRDAAVLRDAAEVTAPGAVAGSKPGQYSQSYDYAGKDTTKPVVKLTDPANLDGCLPFSAADKAAVAGKFVWLEWDDNDATRRCGSAGRSNNASAAGAVGAVFSSALENFNAGIAGNAAIPVFQFTGSATASLRPALDAGTLVVRLAGDLRTSLPTYNQALTDTPSTFTSRGVRGPVVKPDVAAPGDTIASALVGSGNKTLVISGTSMAAPHTTGIAALVRQAHPDWTTEEVKAAIMNSAGADVKENGKTFAPNRVGAGRIDGKAALDNQVLAYVEDDKGAVSASFGTVEVAKPVALTKTIKVVNKSTKWVDYKVGYEALTTIPGVAYELSAETVRLAPRGVAKVRVTLRITDPKALAKTVDPTIVPTQLGVPRQFLADASGRVVLTPKSGATVALRVPVYSAPKPAADIDTVNTLQFKGKNTQAVLNLTGRGVDQTGYRSLISVLELQATSPKLRDCKRNVTTNCALNETAKGGDLRFVGAASTAPLARQQGKAADSVLGFGIATWGNWYNLGNNTSPFVDIDTDGDGTFDFEVYATKLSDTDLLVAATVNLATGATVSVQPVNGQWGDVDTNVFDTNVVVLPVPLVDLGIDPNGSTARLSYQVGVTGFYKAPGATDGLVDSIGKKLSFDPLKPGLWVQGGGDAALSYQSKPGTALVVNRDAAALAADGADSLLVINHHNATGDKADVVKVRGGAKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU60</accession>
    <name>A0A7W7WU60_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="16279" checksum="A401D0A7926762D0" modified="2021-06-02" version="1">MPLQTNLGAAITALLTGTTDLGPASTPQNLSYARTWTSGTAAGQADLVWGDTNTLAASATTDVDLAGSLTGPLGGTITFARVKAILLTADAGNANNVVLGAAASNAFVGPFGASTHTVAVQPGGSVLLVAPGATAWPVTASTADLLRVANSGAGTAVTYSLLIVGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP9</accession>
    <name>A0A7W7WUP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="37251" checksum="21C71F05C9CFE410" modified="2021-06-02" version="1">MGMFRRKRPAAVAREVVRDHTYDDAILDIAAEEMDAGHLRAATTVLAECRAEPEVRALRVEVLGEHAIGHADELLELAKTNTDPDLWLLAGTAFIREAWAIRGAGRADSVGKDRFKVFFATLRKAVGPLHEAAKLLPEDAVPWAQLQTAGLGLQVDREQKDEVWREIVRRCATLYPAHWTRLQILAAKWGGSAEEMMAFAQGSADHAPPGDPVVAMLPLAHFEIFLEQFEEAVQARSALKIATLKMRYFSRVRDEIAQAADKWTRTPGGPHPRGLQAHNLFAAAFALADDAPRARRHLLGMRDHVHDVPWSYVAYLADDLEKEYSELANKYLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW9</accession>
    <name>A0A7W7WUW9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator NasT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="134"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21686" checksum="0D6153B70BC83086" modified="2021-06-02" version="1">MTQQAAEAGPAPRRVLVAEDEALIRLDLVEMLREEGYEVAGQAADGEEAVALATELRPDLVILDVKMPKVDGIEAAAAIAGGRIAPVVILTAFSQRDLVERARDAGAMAYLVKPFAKRDLVPAIELAMSRFSELQALENEVAGLTERLETRKVVERAKGLLMSKQGLSEPEAFRWVQRTAMDRRTTMKAVAEAVIENFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV19</accession>
    <name>A0A7W7WV19_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16723" checksum="A5AA947061430174" modified="2021-06-02" version="1">MRTRSVAFLITAALAVYFVLLGGRAVVLLGTGDPVGIGLGIGVLVLPVIGVWIAWTNLRFGFVTERMARRLDAEGGLPDVSDLPRRPSGRVERDAADALFERRSAEVEESPEDWRRWFLLAQAYDLAGDRGRARETMRRAIELFQAPSNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL1</accession>
    <name>A0A7W7WVL1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032349">
        <property type="entry name" value="DUF4865"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16157">
        <property type="entry name" value="DUF4865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="20508" checksum="961DCEB0BDB16C94" modified="2021-06-02" version="1">MQYEITLPADYDMGIIRDRVATKGHLLDAFPGLALKAYLVREREAGSPVNAYAPFYLWRTAEGMNSFLWGAGFRGLSADFGRPVVRHWVGAGFDRGPAHDGTPTAATRVVDTLAPDADPAEALDRALARAAEHTPDVHSVAVAVDPSRWELVRFTLYAGEAPDEGVRYRVAHLSRPELADLATGRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL3</accession>
    <name>A0A7W7WVL3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ORF">F4559_002012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="11"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25155" checksum="1F205727EE236822" modified="2021-06-02" version="1">MSRPEVLVHRDGDLLAAAVAARLITALVDAQRVRGVASLVLTGGRTGTAVLERLRGASARDAVDWSRVDVYWGDERFLPAGHPDRNETQARAAFLDHVPVSRVHAVEPSDGRFGDDPDAAAAAYAAVLDPMPEFDVFLLGVGEEGHTASLFPSSPAVLERERTAVAVRDCPKPPPTRVSLTLPAIRRAREVWLMTTGEAKAEAVAAALAGASEVDIPAAGATGTGRTLWLLDTAAAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL4</accession>
    <name>A0A7W7WVL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Superfamily II DNA/RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="500"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="694"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1260" mass="134125" checksum="0F30C672A2B67418" modified="2021-06-02" version="1">MDTSVAGVVEARWGVRPEPAIARYAEPGWQLSPVPLDRSCPTCSGELHGLYRAHPDRGRQQLQAAVVCPTCPASFTLRELKLAQKSVLGDLRPAAVSRRLAEDALLAELAADRRRDSPATTPSTGTDPIRNTPGRTHSTTPDQHEPDHQDRTGTGRTHSRRPDRPVPGRSTPDRPALDRPAHHRPVPDRTGPDPVADSDATADRPTSTVPGTAATPPPRDSGRPTSTDSRARPSTSRRPDHRTTTPHDPGPPDATDPQAGRPASRRPTPTAPDTGHPAPSPHDRRHTTPDTATIAAAAGDTDRTPTSPRDSGPGGSGARPPGRRLSTIAMAARIRSVLGGSEPAAAKAAAPELPPGVAASVDPRPVWWCKSADPDLAVPDLGADVDARVLLPDLPAFDGLRARLDARGVPHRSVRHWVEHETVVAGRAQAALSQLGGVVADDCEPVGGDGAVAARLAFETAWNLHDPVAASVPDPVPVPARWARYLPFPLLNPAQAQAAPHLLDGDSHVVVTAPTGAGKTTMGMLAVLRAVLDEGRKAAWLVPQRSLTDELDRELETWRDQGLRVERLSGEYAVDVEAVKAADLWVATTEKFEAICRASSLQAAIGEVGCLVVDEIHLLGSPGRGALLEALLARVRGADSPVRIVGLSATVSNAAELAEWLEADLVTTTWRPSRVTWQLPTLPASSAFGASGRLREQAVVDLVHRHTAERGSVLVFCGSKRNVRSTAMAVAAERGAAVHTVAADDADGLARVCAEVGVRLHYAGYEHRHAAERAFRSREADVLVATSTVAAGVNLPARAVIVRDTTIGGEPLDTSTVLQMFGRAGRVGAGETEGWSYLLVDETERAAWQTRLVSGYAVYSRIRESLPDHVLAEVLQGRITTVDDAAAWWVETLAHAQGDDDAEPVREAVDFLVDEGHLTADGDRLAITEPGRLTARMMVSTAIGHRLRRTLGLLPVPTDPDSAEDALCLVLSVAVRDLAGLPVPEHVRPAVATVIKAGGRTSRITGTTSVKGLGSQATTAPGDLAWAGLLLAARSPHVFTSRRRVAGGIPLSTLYPVYDQAPRFLAWLAAQGVLGTVHPWIAIVAADLDQRVRWRTLGARRGSGRLLWMCEQLATRATDRVPDLWRSATARGVTSPDWPPGRSPAGSQLDHAGYTALLRERATTASLTTNPDTGTATGLPGASIVAWRGDTFTTPVHGKSHTTTVPYPEGTDPDTGIAVFTRRGDYRATGWLSDYHATNNKEEDETEPPPPRSLGRRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVM3</accession>
    <name>A0A7W7WVM3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="95"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="273" mass="30585" checksum="E1AF2A2BCA8AB6CA" modified="2021-06-02" version="1">MAVPNPLRVELGQRLRTYRERADVSLRRIDEDAQLGWYPGKMSKVETGTRVPATAELHRIADLCRVDQDERANLVALAAGARKRTRMPHVADWAQSYVLLEQAATAIDYHDAELIPAILQTEGYARALLGLGDADHLDERVAERLSRGELLDRPNPPRVRVVLGEAALHRLPPEVHEAHGQLENLIRPRPTAEVRILPFERGLYQMIGVGFTTLHLSALATSRVYLEGATTATYLHEPSEVAVYEAKFEKLWTLAASADESATIVRRLIQRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP5</accession>
    <name>A0A7W7WVP5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unspecific monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="48215" checksum="BA675567FB0B7BD3" modified="2021-06-02" version="1">MTSTEVRPPGPKGRWLVGNTLDYDRDRMGFLRAGHERYGDVFSFDERTIVVRDPDLVHELLIRTNDDFSSASSAVATRFEARTDAETARAWMTARRAGWRGLNRATVIAHTARLRALFERTLDDTGGRAVDVMPLMETYSGRAAADFCLGPDADGIAEVVAENTAAIEPLSGSSQLFPEWFPSRAIRRFRRARDATLDAITTRIHRRRTPHPPDQPRDLLDVLLAAREPEMRELQVQRLIRGILLAAYGVPAASMTWTIHTLVTHPDLWDRVAAESSAWDGDDEPPLSALPQTEAVIREVLRLWPPTWLMGRTAVRPTTLGDWRLSTRDAAMFSPFLLHRDPRWWPDPDRADPDRWLRGETPRKHAYLPFGAGPRVCVGTQLGMIQLTLGAFWLTRNYRVAAPDAAACAPEFHNLLVPQGFRASFTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW48</accession>
    <name>A0A7W7WW48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031570492" evidence="1">
        <location>
            <begin position="25"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="39012" checksum="97135F72108C7C0D" modified="2021-06-02" version="1">MRRGVSTVATAVVLLCGSQVVAVAAGAVAVPLEPPPGNTWTWLAGIDDTGTILGQSRYDPAWPRTVVWPPTGGFRELGEGDPVAVSRDGRVLWQDRAGRALVWQRGTTVEIPKPATARDVGPNAINSAGDVVLAYREPGQDEWENVGVARQGRFRVLEFPSDDALGLADLITDDGTVYGRLAFDGGRDRPVRCGRDGVCRWLPLPPGVGSATVSSANDEYAVGTGDRDGWSVPLRWQGNTVVRLPTGDSPGGVATSVNRAGDVAGSTTRPDGTPHAVLWRHGALVDFDGYDKPSGAVAINERGQVLVSRGRYDEPRRSYVWHAGTFVELPALAPGEGAEAAGFNNTGTAYGVSVAPDGKRRPTRWTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW69</accession>
    <name>A0A7W7WW69_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="3">
        <location>
            <begin position="211"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="34102" checksum="A81A415CB469BEB6" modified="2021-06-02" version="1">MTRYVIIGAGAVGATTAAELHLAGREVVLVARGAHLEALRAEGLRYVRPDGTTTLRLPVVGGPGELELRTDDVLVLATKTQDADTALSAWAWQPVGKGVAATELPVFTLQNGLDSERGALRRFETVFASVVWSPASHVVPGEVVSPAAPAVGVFWTGKYPSGADPRLDAIAADLVAAHHTVHVVPDVVAFKAGKLVSILPNALDALYPATPLRDRAAELLRQEAREVFAAAGIAVADLEPVAEFVIHDIPGHERGGSSTWQSLVRGVTVESEFLNGEIVLLARLHGREAPANAAVQARIARAAADRLPARSLDDDDLRATIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW83</accession>
    <name>A0A7W7WW83_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="25088" checksum="48E5B9F744CB7F6D" modified="2021-06-02" version="1">MASSSPLDHAAWESLHGGHARFAQWHGQVVRYDPEVAPFLALPPESDADVWRDVAEFAGPGGVVSVNLAAFSAPADWEIVEDIEGVQLVDDGVVPEPFPEAVRLGPADVPEIIDLVERTRPGPFRKRTIELGTYLGVRDNGRLVALAGERMNPPGWREISAVCTDPAYRGRGLATRLVLAVAAGIRERGETPLMHALASNVNAIRLYESLGFRLRRRSRIVAVRVPHAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA7</accession>
    <name>A0A7W7WWA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="30859" checksum="948679CDBEA4DD4F" modified="2021-06-02" version="1">MLWVVAVFVGLVVRRHVLVSTVVIGGVLAFTALVGAAAVHPVRAVLVVALGLGAAAGLVLLSKEARRPVVREVVRGGGESARQAGARDDVVATALALSVFASSVALASMTAVVALWDSVSGNPARGTLITAGVLAVLAGAWWTADRRRRDVAAGVGFVAVAGTGLVALVAGGVVVFDRVGRGLAFVGAAVAAHPWRAAAVVLALVAMAATVGSVVLPRRDELGGRLRIMAVFAAGGVSVIAVGGMAVWLFTTTAGLWVLGGVTAATVGVGCVLAVRRGLLDARRVSVVAGVLALIALAWFAVARLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWF6</accession>
    <name>A0A7W7WWF6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylornithine/succinyldiaminopimelate/putresci ne aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="520" mass="55132" checksum="7767F3428E30A8A4" modified="2021-06-02" version="1">MTAVQPMTAAHTDRELAEPTLRGWLGTVGLDVEYVRAEGNTIYRLAEDGSEVAVLDLAGGYGSLLLGHNHPTVVARAQELLAAGTPIHAQFSRHPYANDVANRLNRIIRRELGEDEAFATIFANTGAEAIEAAIKHAELERGFRARDLLAGIEANLATTVTSVAPSAYEKAGSVPEEGLAGLLTAIAAHNAAVAARPPVFVTLEGGFHGKLAGSVQLTHNADYRTPFSALAAQARFVPLDQPGAVKDMVDGERASVLDIVVEGGEVRVVEHDFPLIAAFVVEPIQGEGGIRVVSAELAAEIQEAAASVGAPVVVDEIQSGMGRSGAFLASTLIGLRGDYYTLAKSLGGGVAKASVLLVRESRYRPEFELVHSSTFAKDAFSCHIASTVLELLESEDGRAYRKAAELGERLTAVLEGVRADYPDVVVDVRGKGLMLGLEFAAQDTATSEAIRVNAPFLGYAIAGYLLQAHDIRTFPTASAVTTLRFEPSVLLTEEEIGRLDRALRGAAEILRTQPEHGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWI5</accession>
    <name>A0A7W7WWI5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4721" checksum="186E42456D5D5547" modified="2021-06-02" version="1">MNVNYRWEVSCTGMLTPAHVKTVVVVLILVWLLVSGATLPVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWI6</accession>
    <name>A0A7W7WWI6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014303">
        <property type="entry name" value="RNA_pol_sigma-70_ECF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02957">
        <property type="entry name" value="SigX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="31071" checksum="A0649E06D5DB0587" modified="2021-06-02" version="1">MTSAFVAHRNLLFTVAYEMLGSAADAEDVLQETWLRWAGVDHGEVRDARAYLVRITTRQALTRLRVLGRRKESYVGQWLPEPLLTTPDVAEDVELADSVSMAMLLVLETLTPTERAVFVLREVFAVDYDEIAAAVDRNPAAVRQIAHRARSHVAARRPRETVSPDETRDVLEAFRRAVETGDLQGLLDVLAPDVVLVGDGGGIKQALPKPVVGADRAARVLLKGAVGLVLEPAYVNGHPALVVRVEGVLDSVVAVHVENGLVAGLYAVRNPEKLSHMAEETVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU6</accession>
    <name>A0A7W7WWU6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031065307" evidence="2">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26665" checksum="ED895C465474B29B" modified="2021-06-02" version="1">MTCRKLSAFALAVALTVLSCVPAWAGETVKPPSQSDFDAALAAARTPAAMSYARTNFRQVAGAEPAAVTIADRGVAVYMLNPDFVRDVPDAPVGIVQYIAVTATADTGVRATLRASPEGADNAWTVGSVFSGDDEETLSRDLAPGSVLLNEPQINGWYALTATGVTLLRASFPQSEVGQSVSLDEYGKQVRARYRAHLPEAAPTTEAERGPSTVGLLVAGCVVLLVFVLVFGRSRRHSQRKSTPTSDGARLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX32</accession>
    <name>A0A7W7WX32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="138"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="34085" checksum="DDB684F731E05DCD" modified="2021-06-02" version="1">MPSPTARALRALEILQARPGTTADQLAERLGVTERAARRYVGILREAGIRVDSTRGPHGGYRLRRGTRLSPVVFTQDEVLSLVMAVLDSHPTATDSALTKVLRALPEDIAHHAAVLREHAATAPDRQAARPDPATASALVAAVAARHRVVIAYRGTSGDEWRAKVDPWAVVVRHGRWYLLCHSHRADAVRTYRVDRIRAVVRTAREFQPPADLDPVATLEENLGRGWAHPTRVVFDAPLDAVAHWVRPPMGRLEPLGDGCVLVGSTGNPAMYAQEWLAAMPFPFRVEGGDALRAAVAAVADRFAAALDHRAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD3</accession>
    <name>A0A7W7WXD3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23498" checksum="0497C0D3F7D8A53D" modified="2021-06-02" version="1">MTSSGEDEVRVRVFVVDDHAVVRSGVRAEVGDRVDIVGEADDVASAVQGIRALEPDVVLLDVHLPGGGGRAVLDDVATAYPQVRFLALSVSDVAEDVIAVIRAGARGYLTKAVSGPELVDAIIRVAAGDACFSPRLAGFVLDAFRGGPSTSPDPDFDRLTRRERDVLRLVAAGYTYKEIGTRLSISARTVETHAAAVLRKLQLSDRRELTRWAADRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ6</accession>
    <name>A0A7W7WXJ6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="8">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisS</name>
        <name evidence="10" type="ORF">F4559_004546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="423" mass="45237" checksum="9840F54F03B410DB" modified="2021-06-02" version="1">MTESTAFAGPKGVPDYFPPASDRFLAVRDTLLGATRLAGYGYVELPVFEETGLFARGVGESTDVVSKEMFSFTDRGGRSVTLRPEGTAGVMRTVIEHGLDRGQLPVKLAYAGQFFRAEQPQAGRYRQFHQVGVEAIGVDDPALDAEVIAIADEGFRALGLTGYRLELTSLGDATCRPAYRDKLQAFLATLPLDEATRRRAELNPLRVLDDKRPEVRELVADAPLMVDHLSDDARTHYEQVKAHLGALGVKYVENPRMVRGLDYYTKTCFEFVHDGLGSQSGIGGGGRYDGLMARLGGAELSGVGFGLGVDRALLACQAEGVGPGEPTRCDVYGVPLGEAAKARLVGLSAGLRAAGVRFDLSYGGRGLKGAMKGADRSGARYALVLGERDIEAGVVQLKELATGEQRSVPLDDAVVAVREALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR3</accession>
    <name>A0A7W7WXR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030827750" evidence="1">
        <location>
            <begin position="31"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="84"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="513" mass="54940" checksum="E2E73FD1EF591F35" modified="2021-06-02" version="1">MTRTRAALVAIAAVAATALAACTGTGGGGAAPTDAAGAPQIDELKAGVFLDVTSWDPANADIGFDGPYLSAVYDPLVSLDKDGKPVPGLATSWEWSADRLTLSLKLRTDAQFEDGQKFDSAAAVANIDHLKKGVRSGQAYLNVASAEAKGPDAVDLKLSKRDDALLYQMGLGRSWMASPAAIQANSLVNAPVGSGPYTYDKALSAPQSQYVFNKKDKHWDSATFPFPKVTLFPITDQTAAFNGMLSGQLNMQFANAANLPKAKENNWNVASKAASWVGVQFADRTGGQVKALGDQKVRQAISYAFDSAGILSAVAAGSGTVTNQVFSVDAQVYDKSMNDKYKTDMAKAKALLKEAGYADGFSVKMPMSPIFAAWQPVATQTFTELGIKVEWVDMAMPDYQKNAPTYPMFLAVIALAGNDMATLTDQVTTAQWYNPNPAVDAFPEVKALVEQVEKAEPGDAQTALLKQLNTKLVDLAWWSPWYQADNTYFSVQGIKVTPMTGMMFPTLRFIQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY7</accession>
    <name>A0A7W7WXY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="23940" checksum="EBBCEA470D80D64E" modified="2021-06-02" version="1">MRVLLVEDDDRVAEALVPALTRRGFTVVRQATGRGTLDRLAGIDVVLLDLGLPDMDGVTLCRHIRAASDVAIIVVSARGEIDDRILGLHAGADDYLVKPYDVGELVARVHAVRRRRGDPVSTATAVFEVADVRLDLARHEVTVGGEPVALSRKEFQVFALVVAAGGAVCTRERIIAEVWGRSWAGANRTLDVHVATLRTKLGRPALLETVRGVGYRLNADGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE4</accession>
    <name>A0A7W7WYE4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase (NDP forming)/GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="666"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="863"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="885" mass="93705" checksum="304204DF5DD31D24" modified="2021-06-02" version="1">MDPFDHPRHWEADVVLSDGGTVHVRPITPDDAERLVAFHGRLSERTRYFRYFGPYPRMPRRDVERFTTVDHADRVALIALLGDDIIAVGRYDRIDAGRSAEVAFVVEDAHQGRGLGSILLEHLAAAARERDLSRFTAEVLMENGQMVRVFRDAGYRVSRAFEEGVLHLEFDIDPTEESVEVARAREQAAEARSVHNLLHPRSVAVIGASKDRTKIGHAVLTNLLRADFTGPVYPVNAEHRSVRGVRAYPSVLEIPDDVDLAVVAVPAASVDEVMDACLAKGVKALVVVTSGFGETGPDGRYAERRLTAEARAHGMRVVGPNALGVINTDAAVRLNATLAPVLPARGRTGFFCQSGALGTAILATAAERGLGLSTFVSAGNRADVSGNDLLQYWETDPSTDVVLLYLESFGNPRKFARLARRLGRTKPIVAVKSGRHAVTPALAATSVPVDESSVQALFEQAGVIRVESLAQLFDTALLLAHQPLPAGPRVAVVGNSTAIGLLAADTALAQGLELVGVPVDVGAQADPEVFAGAVRDALRDTDADALVVVFVPPLAVPGAEFARALRAAVAGADKPIVSTFLAAEGVPDELAVPGPGGAPGRGSVPSYPSPERAVLALARASRYARWRSAPQGRFVRPEGVDADAAHTLVASLDVTEVRRLDDSTAVRLLACYGVEVVPFRVVATADEAVVAAADLGYPVAVKSTDERLRHRTDLVGVRLDLHGADAVRSAHAMLAEVAGDGEVYVQRMAPKGLSCVLGLQDDPSFGTLVSFGLSGVVSDLLGDRAYRAVPLTDADAAALVRAPKAAPLLAGYGGAERADLRALEDLVLRLAALAEDVPEIRGLALEPVLASAAGAYVGSARLTIGPPPSRHDTGPRRLRQPGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYI1</accession>
    <name>A0A7W7WYI1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="9" type="ORF">F4559_005611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="30336" checksum="ED3BA67FEAFE26EE" modified="2021-06-02" version="1">MTSSAEVAAPYGGGADRPLKRVRVHHLRELKQRGEPWPMLTSYDMYTAALFDEAGIPVLLVGDSASNNVYGNETSLPVTVDELIPLVRAVTRATKHALVVADLPFGSYQVSVEQAVATAVRFMKEGQAHAVKLEGGRHFAPHIRAIVAAGIPVMAHIGFTPQSEHQLGGYRVQGRDAAFDDVVADALAVQEAGAFAVVLEMVTAEVAKRITHDLEIPTVGIGAGPDTDAQVLVWQDMMGLNRGKGPRFVKRYADLAGVMSAAAREFAAEVRGHAFPGPEHTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ4</accession>
    <name>A0A7W7WYJ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease ATP-binding subunit ClpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17352" checksum="B1FF6094EB3E4C09" modified="2021-06-02" version="1">MQLQWDERFSSRLTTALAFALTSARDHGGAEVELGHLWLGLLAEGEGSAYRTLVSLGVDLEQVRLDIGASLPEARRPTDGLSVEAVVREWRTLLARPLSAAAQTVLSHARAEAFDRIGTGHLLLGLLRLDPRGLDLVRVRAEVDQQLAACAALGEHDQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ06</accession>
    <name>A0A7W7WZ06_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15402" checksum="A6284727BFA94C65" modified="2021-06-02" version="1">MGRIPDFLDRHRYPGAEDSIEVAKQRREPLNIRRVLVKAAGISAAGMLVFVPVASADVHALGAVYQGDDYAWSNGSDVEVCDREADGHGVYGEFNLSGGSKATVRDTNGSASGCGTNRFNGVRTFRVCEVLNNLPDPCSSWGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ33</accession>
    <name>A0A7W7WZ33_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_005732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="11">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34034" checksum="E32843316FA11F42" modified="2021-06-02" version="1">MSATPLTPGTPRSRSAKTAGLVTDGRASSTYDFLRPANLPREHLRILQIAYETFAHRLSVLLTSNLRVVCRVAMTGIEQVSTRTVLTEQTDDLIAVSIGLSPLSGAGVLVFPRELAMVWIDHMLGGTGGGEQPRRTLSDIETPLVRELLTDALAELGAAYAEFAAVDLVLGVLEYDPQLVAVGGPADALVKASFEIAVGTAASELTFSVPVQAVQPSLQRRLDSTAISAGEQAARAAARDLLTESLSDVPVEVAVRFSPARMRSEDLLDLRVGDVVSLDHPVDRPLVITTAGGIFGRAVPTARGTRLTCQVVATESEESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXF2</accession>
    <name>A0A7W7SXF2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="25557" checksum="734266774CB6CA1E" modified="2021-06-02" version="1">MGPKPHGGFLLAVLARAAVHAVGSRVASDELAPLVVSGQFLRSPEVGPVLVRTDVRRVGRTASVVNAVLEQRGRSCVEVSVTVGVLPSSVPEYSALPEMEGEPPADAVDLASSTPRGVFNLSSVCDVRLDPRTAGFLFGRVGDPLELTLWARPRGERPDPYFALVVGDISMPVTFNLGRFGWSPTVQLTALVRGVPAVGWLRARFSCSSVAGRWFDEDAVILDSSGALVCQARQLALTPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY34</accession>
    <name>A0A7W7SY34_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6681" checksum="744C9DE5ADAA651D" modified="2021-06-02" version="1">MANLSIVEPFTENPEPPVGPPTPVLGGGGGLFVFVLVFVFELEFVLVFLAMTGSLRLRKDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK0</accession>
    <name>A0A7W7SYK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10455" checksum="A9D6D18704418735" modified="2021-06-02" version="1">MSGFKVQAQQLRTFASGQAERQGQVEQAASDVAGVDLGGETFGVLLQFFADAAQDFAAQTTEGIKQLAAAYGDASADTVATAVEYEQVEDGNQQTFDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYL5</accession>
    <name>A0A7W7SYL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6560" checksum="BD678220EB79DA96" modified="2021-06-02" version="1">MVSFVSRTFTTPIPTFHHALPRCWATPSPFREGVPMRAAVVLFAVLVFAVVAPLGGMPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYM1</accession>
    <name>A0A7W7SYM1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15524" checksum="C80D872FF54C05FC" modified="2021-06-02" version="1">MTDGLVRAAAHLTERWRAHPDERPALRAPLARLAGRFRAEADACRERGDLRVAVAQRRRELALRRRLDDPHETTGTLLALVDDYRGLGARRQVLDCADEVLAIARVHRDEPAIVEAHRRLHALLAEFGRPEAVRHDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR0</accession>
    <name>A0A7W7SYR0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative intracellular protease/amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032633">
        <property type="entry name" value="ThiJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17124">
        <property type="entry name" value="ThiJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="30157" checksum="B8614EFCA0FB0BCB" modified="2021-06-02" version="1">MTKRMLVVLSEFGYWGEELVGPVEAFDAAGYRVTFITPNGRRPQALPPSLDAGYVDPPLGRSVTTPDMARRARELDASPRLDNPLSLADLVPERPYYSAVNHLREVEEYNRRLDGAVADLVGSFDALTIVGGSGPIVDLANNERLHELVLGFVAADKPILAECYGVAVLAFARDLESRTSIIQNKHVTGHPKEYDYKDGTGFVGVEFNMGPPPYPLEYILRDATGPVGRFHGNVGRETSVIVDYPFVTARSTPDSTPAGELLVQVLENGLRRFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYV1</accession>
    <name>A0A7W7SYV1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="398" mass="43267" checksum="70087BE7DECFF1C0" modified="2021-06-02" version="1">MPVDPPGLTFPFRGDHPTAPPPEYAKLREHGPARATLPNGHRVWLITRHDDVRAVFADPRFSRAAITAPDAPKLLPVSTGSKSLFVLDPPEHTRVRKLVAAAFTTRRLEHLRPRVAELADGMADRLVAEGPGADLIAHLAEPLPITVICELLGVPSQDRTVFRDWTEIMLSFTAHTPAEIGAAVRSLRGYLSALVEAKREEPDDGLLTVLIRARDEDDLLSTDELLSFGQTMLVAGYHATAAEIVHAVLNLAARPDEVERLRQDPASIPTAVEELLRYSQAGGGVGPVRIATEDVDVGGVRIAAGDAVLPSINAANRDELVFTDAEELDLTRAHNPHVAFGHGIHHCLGAHLGRVELQVVLETLLRRLGAFRPALPAEDLVWRTGTAFARPQTLPLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX1</accession>
    <name>A0A7W7SYX1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18738" checksum="C817253CA00CCE2F" modified="2021-06-02" version="1">MTTTDTTCLQFLWAEDEIDEATHRHPTKADLLHHSFALLTPTHPLMATEFVHRSHCRDLLDRVAAGTDTRPATAAELCCASCEASQIAPLTRAATGLYFRMWAQAFPHLPHASDLLPHLEAVDGDRIDDLETHHRRTLSIPTRTLGPVECSGLHHGKPTKCRYATDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ37</accession>
    <name>A0A7W7SZ37_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031097961" evidence="1">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="13768" checksum="BE4BFC756C7C5298" modified="2021-06-02" version="1">MRRPWLPAVFVVVLSGCSVEAASTPLPVRQADPAFVAPVTTTRLATGARLSALPMAGKAGDKVKLTGQGFPPNARVVLSFHDTKVGEVTADAVGGFADAEVVVPDSFGGSGPGTQFFLRAGAGPYQAEAPFVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ54</accession>
    <name>A0A7W7SZ54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031400706" evidence="5">
        <location>
            <begin position="36"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="48735" checksum="CE630E84EBA97D59" modified="2021-06-02" version="1">MRQAATRLVKTTVLVVAALGVAGCTQVVPGRPVAGASVAKGSVDPSFIKGTDGGPIDRLAATAITDVETFWKQSFPETFGKQWTPLSGGIYSVDTADKQAKPPPCTEKASDVEGNAFYCPSADAIAWDRAALLPVLQDRFGDAAVVIVLAHEMGHAVQRRMGITPEAERRDPARYPTILTEAMADCFAGSFVKWVNDGKSENLDIGSDTLDSALGALITFRDPVGTSAGDRSAHGNAFDRVSAFQDGYQRGTKFCADMSVENRAFTQKAFTSVEDRDNGGNLPFQEMLRLITPDLDAYFKSVVEAGGKTWTTPQTKATEQEPECSGDQGPIAFCPTGRTIEIDTAEELPELHAEIGDYATGVLLAGRFGLVAMSVLGVETKGEKAATSALCLAGAYTREVFTRGRGFGLSPGDLDEAVQVLLAYDYAARDGVGGATVGPGFKRVDVFRSGVFEGIGACGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE8</accession>
    <name>A0A7W7SZE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="33056" checksum="5ECF98C9470A556B" modified="2021-06-02" version="1">MPHPVIAWDGQPVGDRYPAMDVVPGVLPWSTLDQDSRPWQDRKKHWHDLGVRDTTPRDHAAGMMTTGRHGALSGGVSRFDPVLAEVLYRWYCPPGGRVLDPCAGGPVRGLVASHLGLEYVGVDLDADQVDANTAVAAGSPYPSPAWFAGDALTYAWPVSDGDADMVLTCPPYHDRERYSDDPRDLSTMDWPAFLDAHRAVVGRAAAALREDRFLAWVISDVRDRHGHLRGLPRHAWQHLEDAGLHVVNEHVLRAPVGTAHKRMRPPWQACRTATRRHQIVLVAVKGDRRAATRAVSGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZF7</accession>
    <name>A0A7W7SZF7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="191"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="390"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="579" mass="61799" checksum="E9DC9BE62BDF85E2" modified="2021-06-02" version="1">MTGAQSLVRSLEAVGCEIVFGIPGGTILPAYDPLLDSTKVRHVLVRHEQGAGHAATGYAQATGKVGVCMATSGPGATNLVTPLADANMDSVPVVAITGQQSRPLIGTDAFQEADICGITMPITKHNFLVTDPADIPRAIAEAFHLAATGRPGPVLVDIPKDVLQETTSFSWPPELRLPGYRPTTRPHGKQVREAAKLIAGARRPVLYVGGGVIKSDSSAELLTLAELTDIPVVTTLMARGAFPDSHRQHLGMPGMHGTVAAVAAMQKADLLVALGARFDDRVTGQLASFAPEAAIVHADIDPAEISKNRRADVPIVGDCKEIIGDLVEAVRAERENGEVVDLAPWWSQLDALRDTFPLGYDWPDDGTLSPQYVIERIGALTPADTLYTAGVGQHQMWAAQFVKYETPRTWINSGGLGTMGFAVPAAMGAKAGVPDVQVWAIDGDGCFQMTNQELATCAIEGIPIKVAVINNGNLGMVRQWQTLFYGERYSNTDLGTHKHRIPDFVLLAEALGCAGFRAESKEEVDKVIEQAMEINDRPVVIDFVVGKDAQVWPMVAAGTGNSEIMAARGIRPLFDEDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZR5</accession>
    <name>A0A7W7SZR5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="5" type="ORF">F4559_001297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15840" checksum="38C62B089089B1EE" modified="2021-06-02" version="1">MAVKIKLQRLGKIRQPYYRIVVADSRTRRNGKAIETIGKYHPKEEPSFIQVDTDRAQYWLGVGAQPTEPVQRLLEITGDWQKFKGLPGAEGTLKVREPKPSKADLFAAALAAAGEEPTTEATTPKKRAAKKADAEPAAEAKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T008</accession>
    <name>A0A7W7T008_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="7" type="ORF">F4559_001408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="10349" checksum="1417488055E36C71" modified="2021-06-02" version="1">MALTTEQKKTILAEYGVHDTDTGSAEAQVALLSKRIADLTEHLKKHKHDHHSRRGLLLLVGRRRRLLNYLQKVDIQRYRTLIGRLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T028</accession>
    <name>A0A7W7T028_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="74" mass="7485" checksum="28821783EF7379A6" modified="2021-06-02" version="1">MDLHAAIDIALAELRRSARATGTVSGTSGTKVVVAVSGGTLTLPRLASYTPTVGDVVVIDTLQPGAWLVLGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0F7</accession>
    <name>A0A7W7T0F7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="258" mass="28122" checksum="390613F93C77FAE5" modified="2021-06-02" version="1">MSTPVLKLDQVVMQFGGVRALGGADFHIDQGEIFGLIGPNGAGKTTVFNVVTGVYQPTEGQVLFNGARIDGKKRFRITKLGIARTFQNIRLFHNMSALENVMVGADAHHRTGAIGATLNLPWHRKEEKRGRELARELLDFVGISARMTETAKNLAYGDQRRLEIARALATDPKLLLLDEPAAGMNPAEKEALQALIRKIRDSGRTVLLIEHDMSLVMGVSDRVAVLDFGQLIAEGLPADVQNDPKVIEAYLGVSEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L9</accession>
    <name>A0A7W7T0L9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">F4559_001730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="127"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="39025" checksum="8595B7FAD140A14D" modified="2021-06-02" version="1">MSGANDPYDPKQVAALSPEALDAAVEQAREAFAKAADLDGLAAVKPAHLGDRGPVQLARREIGALPPQAKADAGKRVNEAQNAVKLAFEERRAVLQTERDERVLREESVDVTLPWDRVRRGARHPISTLAERIGDVFVAMGWEVAEGPELETEWFNFDALNFGKDHPARSMQDTFYVAPADSGLVLRTHTSPVQAHTLLDREPPVYVVCPGRTFRTDELDATHTPVFHQVEGLAVDKGLTLAHLKGTLDAFARAMFGADSKTRLRPSFFPFTEPSAEVDVWFPERKGGAGWVEWGGCGMVNPNVLRNCGVDPDVYSGFAFGMGLERTLQFRNGLPDMRDMVEGDVRFTQPFGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0U7</accession>
    <name>A0A7W7T0U7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="29744" checksum="2B0216C4B742E365" modified="2021-06-02" version="1">MSAGGEQGAAESAPKGASRAGRDLRAAITVGVGLGAVILVSLFTIRQLFVPVVAVAVAVSMYELAGALRRGAGINVTMVPALLGGQAVVWLAWPYERGGMLTAFVVTLLVCLIWRLKDGSEGYLRDVTASVFTVAYVAMFASFAVMLVAPEDGVYRVLAFLIGVVLSDTGGYAAGVFFGRHPMAPKISPKKSWEGFAGSLAAGMIGGALTVGLMLDGQWWQGVLFGAALVVTATTGDLVESLIKRDLGIKDMGTLLPGHGGLMDRMDSLLPSAVVAWLLLDLFVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z2</accession>
    <name>A0A7W7T0Z2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16287" checksum="C01740B9D9BE699F" modified="2021-06-02" version="1">MTSTPEQRLADLARLRRVRDRIDREYAQPLDVEALARGEHMSAGHLSREFKSAYGESPYSYLMTRRIERAMALLRRGDLSVTEVCFEVGCSSLGTFSTRFTELVGVSPSAYRKNPDATPAGMPSCMSKQVTRPVRNREAGSRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T136</accession>
    <name>A0A7W7T136_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative DNA-binding transcriptional regulator YafY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="319" mass="35104" checksum="8C33E2D40DD682D2" modified="2021-06-02" version="1">MLETSARLLRLLSLLQVRKDWSGPDLARRLDVDVRTIRRDVDKLRSLGYPVDSVPGVAGGYRLGAGAELPPLLLDDDEAVAVAVGLRTAANGTVAGIEETSVRALAKLEQVLPARLRRRVNALQTHTIALTPSVATVSPDVLTTIAGACRDHQRLRFAYTARVGDATRRHVEPLGLAHTGRRWYLVAWDVDRDDWRTFRIDRIEGEPALGARFTPREPPAADLADYVARQLTVAPHARQARLIMHAPYEEVAARTSVTAVHLERIDDHRTRLTVGAPSLPEVGLWIGTLGLEFEVEGPPELAGHFRELAARLLRAAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T138</accession>
    <name>A0A7W7T138_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="92" mass="10699" checksum="BF325D06F66F5B46" modified="2021-06-02" version="1">MRVISQREFRNNSAAVMDAVEAGETYHVTRNGVEIAEVRPLPRRRRLTAEELVARHRKLPRVDYDHMRREADDLFGGEDRIGADDPWERGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T147</accession>
    <name>A0A7W7T147_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031300214" evidence="1">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12993" checksum="B6062631D5AF14F4" modified="2021-06-02" version="1">MSFIRNALVTVAAAASVFALATPAQAATGWDRCNPGYICLFDYDNGQGPMAWFQIGSPDLRQQDFDNRTQSVWNRTSSRFCLYVNYNYANDQGAGTSFSGIQYNTNEVNSYSSLKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B3</accession>
    <name>A0A7W7T1B3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="30983" checksum="3F84A4EB3CDC4F17" modified="2021-06-02" version="1">MDLTMYQLRTFSDVARTGSITRSARNLGYSQSSVTAHVRALELRVGATLFQRLPHGVRLTRAGEMFRGYVDQILAVVDKMSTALQRKGEAAGRVAVGATAPLVDTLVPRLVADVQGRHPRVRVSPRVLAATDLVAQVGDGVDLAFTLDDRTVGTVPRDRGVSTAELFAVELVAVAAPGGHEDRLVAADSGCVSHRALVRAAKDGRVGDRAVVETGSVAGARDLVLAGAGVAMLPLAAVTRHLASGALVEAAGIGRVTPVVTAVWPDQDWTSPAVAATLEIVRRQGARILRPEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W8</accession>
    <name>A0A7W7T1W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12407" checksum="40BE0F3EBD0A5DA2" modified="2021-06-02" version="1">MRWSVDHSSREALPLQIAACVRQGVASGELVVGEQLPPAAELAEALSVDRNTVLAAYRKLRDDGVLEFRRGRGARVASAATEPAPVVEAARTLVALARDHGLGRRDLVRLVDKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X0</accession>
    <name>A0A7W7T1X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030993064" evidence="6">
        <location>
            <begin position="31"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="146"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="39809" checksum="CE5902FB503003C4" modified="2021-06-02" version="1">MGTRKYAVAAIVVTALAAGAAPASAGPAQADFVPATRPVPGSFLVSLEGGDARVASAGLADRYGGTVERVFTVAMNGFLVHGLSDRQARRLAADPAVRSVHQDGTSRLADTQTNPTYGIDRVDQRALPLDRRYSYNTTAATVTTYVLDTGIRKTHTDFEGRVSDGYDFVDDDKVAQDCHGHGTHVAGTIGGKRWGVAKKTKLVALRTFDCAGTGPDSDGVAAIEWVAKNAVKPAVVNGSFTFDTPGIGDEAIGRLTAAGIAFVVAAGNDSSDACGVGPSRHPDVVSVGATDSGDNRAYFSNYGTCVDVFAPGDGVTSASYASDTASTSMSGTSMASPHVAGGAALYLATNPTATPAQVRAALTGAATPNVVKNRGTGSPNRLLYTAGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T204</accession>
    <name>A0A7W7T204_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">F4559_001946</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="318"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="42066" checksum="26523AD6A8C216AD" modified="2021-06-02" version="1">MLRWITAGESHGPALVAVLEGMVAGVEVTTADLTAQLERRRLGFGRSPRMGFEADEVEILGGVRHGLTQGGPVAVRIGNTEWPKWQTVMSADPVDPALLKPTGRNEALTRPRPGHADLPGMQKFGFDEARPVLERASARETAARTALGTVARHFLKQVFDADVLSHVVSIGKAKTPADAAQPGPGDLAAIDASPVRAFDARGTEAMVAEVEAVKEAGDTVGGVIEVIVYGLPPGLGSHVHWDRRLDARLAGALMGVQAMKGVEIGDGFTTAERWGSEAHDEIDRGTGPKGVTRRSNRAGGLEGGITNGEPLRVRVAMKPISTVPRALSTVDVRTGEPAVAIHQRSDVCAVPRAGVVLESVVALVVAEAALEKFGGDSIDETRRNVAAYLAGLEARWEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T272</accession>
    <name>A0A7W7T272_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="683" mass="71723" checksum="9DA37812F2AA0579" modified="2021-06-02" version="1">MGSKTDNNPPAGAVAVDDPAKVRNVVLVGPSGAGKTTLTEALLATTGVLSRAGTVTEGNTVCDHDPAAVRQQRSVGLAVAPVRHGDVKINLIDTPGYADFVGELRAGLRAADAALFVISAAEGVDASTVALWNECAAVGMPRAVVLARTDHHRADVATQVLACQDAFGAGVVPLYLPGADGLVNLLVTDDPAYEVDRAALIEGIIAESEDETLMDRYLAGEGIDQATLVADLETAVARGSFHPVLPVCALTGIGLTELLDGIARAFPSPLEHPLPEVTGVDGIPHPRLSPDPSGPLVAEVVRTAVDSYVGRVSLVRVFSGTLRPERPVHVSGHGMADRGHEDHDVDERVAHVYSPLGATLREVPYCVAGDLCAVTKLGSAETGDTVSAPERPLLVAPWEMPEPLLPVAVVPRSRSDEDTLARNLGRLVAGDPTLRLERNAETHQLVLWCMGEAHADVVLARLRAGGAEVDTEPVRVAFRETFAASAKGHGRHVKQSGGHGQYAVCDIEVEPLPRGAGFEFVDRIVGGAIPNQFIPSVEKGVRAQLARGLQGGNPLVDVRVTLVDGKAHSVDSSDAAFQTAGSLALKDAAGHSGTAMLEPLDEVAIRLPDDHLGTVLGDLSSRRGRVLGTETDGTGTTVIRAEVPATELLRYPVELRSLTSGTGTFTRRFSRYDPLPHNLAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T290</accession>
    <name>A0A7W7T290_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031114549" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="19872" checksum="2D69F134C7188D64" modified="2021-06-02" version="1">MQRSHGAAVAAVLLCGLTACAQPSDDRASTASSSEVAAGPVRASLCDRLKLADLTSWMKIGGSPVDQATCAAQGSGEARAYGRWTFPSGSVEYIEIVVQDDKRADGSRLFDELRTAYPAHEQRTVAGHYARVANTRGKTLINFPDLAEPVDIVIVTKSTSGTGAEETYAGIRTSHFGAFEQLVPALVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2L5</accession>
    <name>A0A7W7T2L5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21428" checksum="D14AF2EACA8CEF44" modified="2021-06-02" version="1">MESERPGGELLVPTPVKIVVAGGFGTGKTTMVNSVSEIPPLHTEELLTEAGVGVDDVVGLETKETTTVALDFGRITINPEVVLYLFGTPGQNRFWFMWDELAYGAIGAVILVDTRRLDSSFPSIDFFERRGIPFIIAVNCFEGAHRYRAEEVRRALDLDEGIPMVLCDVRDRESAKNVLVSLIQHTMDRLDAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Q7</accession>
    <name>A0A7W7T2Q7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013207">
        <property type="entry name" value="LGFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08310">
        <property type="entry name" value="LGFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031407485" evidence="1">
        <location>
            <begin position="26"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21778" checksum="7C0D3D51ED2B0DEF" modified="2021-06-02" version="1">MIRKTVLTVVVAMLLITIVAVPAEGAARGVLVDNGCVGVSGIFDPRWKMHPHTYGCAISPLWVTYDGRYQNFERGQMVWSPGKGDYMVISGWWSSFAYGGTTSFKLDLEWGTSAPFAYERWHIRLDRDNQLGLAEGTCFVVAGSRCHPTSGSASFTDTVLWPGAIAPGHSYQLKVRGCHSHYDCPEGWTIPVWLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T359</accession>
    <name>A0A7W7T359_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34797" checksum="DFB834AB122A51FA" modified="2021-06-02" version="1">MGEASRVPVRQLGPGGPQVPLFGLGSWNTWDRMEFDDAVALLRRAVEAGATLFDVAHYNFGPHAEQARTDIIFGEVVRAAGLARADYHLCGKLWLWEYPTTTFESQMTTSLERIGVEKADSVVVGDYMSPPDIPAVVTDVNDQIAKGRFDVWGVNNWVAKDLEAALAFADKEGLTPPSFAQLKYSIARRTMAEGEYYGEYFKSGKLALQASDVFEGGILAGRKFPERKIGADPGGIRDAIREAADKVAEIAARHDATAAQVAIAFCLANPAVANVLFGVSRIGQLEDNLGAIELAAAHGEELRTELEPLWTDRGVNADGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3C5</accession>
    <name>A0A7W7T3C5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroQ</name>
        <name evidence="11" type="ORF">F4559_001949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15596" checksum="25F60F204CE0A839" modified="2021-06-02" version="1">MKVLVLNGPNLGRLGLREPDVYGRTTYADLVALCESAGRDLGIEVEVRQTDFEGELVGWLHEAADQAVPVVLNPAAWTHYSIAVRDACAQLVAPLVEVHISNVHKREEFRHTSVISAVADGVIAGLGVRGYVLALNWVADRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R2</accession>
    <name>A0A7W7T3R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like negative regulator of GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="27210" checksum="5F54021A3C97D076" modified="2021-06-02" version="1">MAEPPDRTEARLRAAAREHGPGRPATVATRLELGYLLLDRGRPAEAAAELADLPELLDDVGLAFAVRCDVALLELDRTGSTRALGRVYEAAGEELGRRHPVTLRARAVCSLAMGDGEAVRQVLAEDGSLADVRLRYARLLHELGRRVPAERECLRLIDTLPDDAPDALRARALLAASAHDHGQLAAVVRAQVVLRGPDHPEVAESRLLLGLVLLGLDLPGEHELRAALDIRTRRLGPTHAATLEIARFLPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Y3</accession>
    <name>A0A7W7T3Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="32153" checksum="24309AC36529C957" modified="2021-06-02" version="1">MTTGDTRKTPLEHWRGASVTTKLYWLLRIGVAIEYLGHGWAGLSRSRAWLPYYDLFGISADTAVDYLMYVTGAVDITVGLVVLFWPLRIVLLHATVWGVFTALLRPAVGEGWWEFLERGGNYGMPLALLILVGGGGYSLRRWFTRADPPADVTDRAQVGVHTAARVGLGLLLIGHGGFGAFENKRHWYDFFALFGVGRGTVDDANLMVVFGTFEILLGLAVLIRPVVPLLWFVLGWKLATELLRPLVGQEWFQFVERDGDYVLPVVLIVGAGVYATAYRRLHGTRSSTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T449</accession>
    <name>A0A7W7T449_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030826812" evidence="1">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="18927" checksum="0C0E8989ABCB32FC" modified="2021-06-02" version="1">MKSLLTLATLGVLLTGAAVASASPADGDADRGRPASVTGSAQVRYHYVPTEEIKFEFDAQAAPFTRITPDSPNGRPTDARGTVRISHVIRGTTYTAEAEVDCLLTGGPSATLTALVTATSHGQVPNGERLGFSVLDGHPDRMGFSWGLVDGTDVRPCMAAAPFTTVVKGGFKVHHVDAPKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J6</accession>
    <name>A0A7W7T4J6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2510 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2510" evidence="1">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="20244" checksum="C564761371DA2ABB" modified="2021-06-02" version="1">MTRPAAWLPDPLDDTLVRYWDGQGWTFYTAVREQPARPQPAAQPVAPPQPAPRADIARAVDEARGTLIGAMKEIGLLAEYLRPEERVVALAAAQGEGRGVLTCTNQRLLFVFVGMLRRQVLEVGWNQADSVGYDPRTGIFAVYRGKVTRRSVPVFAVTVPNRADVERLYAAARASSAVPRLEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X3</accession>
    <name>A0A7W7T4X3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="281" mass="30257" checksum="9A3D370F49A57E2A" modified="2021-06-02" version="1">MIDEYDEPAVEDWTPVWTAGEVAARLGTTESTLRGWHRRYGLEPRSGRAGTHRRYSNDDVAVLGRMCELVNGGMRPSAAAGLLNGTPMPRDVRKAVVESARRLDTASCVDLLSRTFPRWGVVRTWDEVCRPALTSIERAQVDDPDCVDDEHALSWSVATALHRVPHPPAGASVLLACAPGEQHSLPVEALSAALAEHDVPTRMLGAAMPEPALVRAVTSTTPKAVLLWSHRIEPAHHRAAEAVAALGPRLVVAGPGWRAPGLSWERPTTLAGAVSVLREVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z1</accession>
    <name>A0A7W7T4Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="18967" checksum="261D440F38496F0F" modified="2021-06-02" version="1">MTWLSTERLTLHRWTGADRNDLAALAALPEVVRHVGDGTPWSAELVSGKHDAALAHWAEHGFGRLAVRDRAGAFVGLVSANRRTAEESHVDGPAVEIGYWVAPSAWGRGYATEMTSAVVAELFARDRADRLMARHFAANTVSGRLLDKLGFTRHHVVDGLVWSVLDRPARAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T521</accession>
    <name>A0A7W7T521_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl diphosphate synthase type I</fullName>
            <ecNumber evidence="3">2.5.1.1</ecNumber>
            <ecNumber evidence="3">2.5.1.10</ecNumber>
            <ecNumber evidence="3">2.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.10" evidence="3"/>
    <dbReference type="EC" id="2.5.1.29" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="37066" checksum="F65932BA488093FA" modified="2021-06-02" version="1">MSVLVRDDHELAADRAAVEAALAAFLGDRTDELAALGVPEFATVGHGFLKGGKRLRPTLCCRGWRAAGGEGPLPHRVAAVAASLELFHAFALVQDDVMDDSDTRRGEPTAHRAFAGVLAGRSRARELGADAAILLGDLLLSWSYDLLYEAECPPPVWRLLRAMHAETLTGQYLDLTGTLTDGVERALRVGELKTAAYTTRRPLQAGALLAGADQNVVAVLGEVGALLGEAFQLRDDLLGTFGDPSTTGKPVLDDLREGRNTTLLAVARHHATSEHRAALDRMVADKTPDPVLLHAILTATSARDRVERMIATRHDQAKALLAGPPLSPARTSLLGRLITTIVYRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T592</accession>
    <name>A0A7W7T592_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9240" checksum="BADC4B0385BEB874" modified="2021-06-02" version="1">MSYTVRLRRDLFAKARNLAGLKSDCALARAMKLNRSTVTRVRSGQLQPGRAFIGGALVALAPFDFHDLFEIRPDDEQPTEPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5D1</accession>
    <name>A0A7W7T5D1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="23465" checksum="B36731A35DB47815" modified="2021-06-02" version="1">MNTNTARPETGRPSTAADNLWIGNDRKQPASRLRASNHRSLPYLLLGVLLVLVCAGGFVLISLDSGDRRAVLALARGVPVGHVLTTQDLRQVNVAVDPGVAVVGADQAAIVVGKPMATSLSAGALLTPDAVGGAALPENGQAIAALALKPGQFPAEVGPGARVSVVFVPGQAGTVTSPPADGGTVWPAVVTSVTTPANDQNTVVSVQLSEAAARQVAAVPAGQLSIVMLSAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H6</accession>
    <name>A0A7W7T5H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4337" checksum="EF51490335891F0A" modified="2021-06-02" version="1">MVDRVVPVRPEQVRGLVGWPASAELLMAWQGPPATPDRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K7</accession>
    <name>A0A7W7T5K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Quercetin dioxygenase-like cupin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12998" checksum="811B4D5CE6C44E8C" modified="2021-06-02" version="1">MTANWQAGNAAEDTTETRGWLVGHFIDPSEGVRSQQDVEVKWFTHPAGDKRVEWTSDDQRTTLVLLVQGNFRVDTTEGNTTMSRPGDYVMWGAGIDHSWEALAESTVMTVRWPSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L8</accession>
    <name>A0A7W7T5L8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10241" checksum="44E56995C18D6C99" modified="2021-06-02" version="1">MRYTVRLRSGDFTKAATLAGLRSDYARSKAMGVHRSTVTRVLAGELRPGAAFIAGALTALHPLDFTDLFEIVEQSPAPKPSVRATVVNLPENSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5V9</accession>
    <name>A0A7W7T5V9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15937" checksum="5B8F994D49BFB3E6" modified="2021-06-02" version="1">MTWTSLAADAPSDWWHNTPTPGPDIDDPARFLSPVTERLLQRVATILAAPPTTRTISPHLHGAISALLATSYGYDAEHRIDPDEITWAYTHGGALHIIEHPDGSVTFTKHHREDCPFITSRGAQECDEDCYFPDPADVERAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6F8</accession>
    <name>A0A7W7T6F8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent Lhr-like helicase</fullName>
            <ecNumber evidence="3">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="243"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="703" mass="77562" checksum="6A25DF2DF1B82A61" modified="2021-06-02" version="1">MTDGSDDLHPTLAHHIVNTLGWRSMRPLQSAAVRPLVTGDDALLLAPTAGGKTEAACFPLLSAMERHRWTGLSVVYVCPLKALLNNLLPRLESYASWLGRRAALWHGDTTSSARRGILREPPDILLTTPESLEAMLVSANVDHKRVFADLRAVVVDEVHAFAGDDRGWHLLAVLERLTRIAGRPVQRVGLSATVGNPHDLLTWLQGSGRGSRPAQVVAPEADSPPTAPASVDIEVDYVGSVSNAATIIATLHQGRKRLVFCDSRQLVEELGAALRSRGVTTFLSHASLSADERHRAEQAFAEARDCVIVSTSTLELGIDVGDLDRVIQINTPRSVASFLQRLGRTGRRPGTTRNCLFLAIRRDEVVWTSALLLLWSRGYVEPVTAPPEPRHIVAQQLLALCLQENRIGARLWDREWNGLTPFDRSAEPVLGHLTDNGFLDRDGELLFIGPTAEQRFGRRHFMDMTAVFTAPPQFTVFHGRREIGRTDPALLTEKVEGPRLLLLAGRSWQVGWIDWKRRRCFVEEADRGGKARWHTSGIGGASFDLTRAAREVLLGERPPVTLTRRAERALADEREDAGSRVYPGGTVITSDGVDTRWWTWAGYRANATLAATLSDLLDERQRVDDASIRLRNDLSREMWRVATTGASGRLVLPEVDEQALTGLKFGEALPTRLAVATLATRIADVQGATRTLAEPVRHHVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J0</accession>
    <name>A0A7W7T6J0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6292 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046259">
        <property type="entry name" value="DUF6292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19809">
        <property type="entry name" value="DUF6292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6292" evidence="2">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18444" checksum="DEB5274D69BA6D00" modified="2021-06-02" version="1">MRRRWCAVGLDFDDTLTRASRRYARSATAALGLSGDCWCVQGERPAGLYLALEGRWGSFPDYDVALLWNEHRGWSAVVETGDGADLVVDRLDGPVVPRSASVAKWIDEIFRRSAAGDPVDDELPRVVGGGPAAVRDLENPTAPRAASRVVGAPRSAGASRGLSRAPRWSGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J3</accession>
    <name>A0A7W7T6J3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YndB with AHSA1/START domain/DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="29451" checksum="F3A6F6BDBF894987" modified="2021-06-02" version="1">MERITAALGDEARWRLVVLLADRPRSVGELAELTGSRQPQTTKHLQTLARAGIVSVHPVGRRRVYALEPGPLTELERALATLIAKTRAHQGEVDVITRYHAAIEAETAIAEKGWADGRTFRFERHLDAPVDIVWQYWADADRLASWWVPPSLTVVECVLEPKKGGRAVLEYRDAEGRYRSEGRVHTAKTPKHLAFDLSVLDAAGAVSFTGHYDLALAPERTGTSLHLDLRITDTDTKAAHFIAGITTGWNQVLDNLTRTIDRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N4</accession>
    <name>A0A7W7T6N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="8608" checksum="85EFCDF7CBF50001" modified="2021-06-02" version="1">MAPVLAAGTRVPGTDNTPRELSAREVEVLQLVADGQSNKEIGEALSLSALTVKSHLSRIGRKLGTGDRAQMVALAMRAGVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X0</accession>
    <name>A0A7W7T6X0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="11093" checksum="32A5C5BADB9EFB52" modified="2021-06-02" version="1">MHALYTEDAVAVWEPGQPLTGEAHRRNVEEAITRGASMEAKTRHAFVTGDTALLIVDWTMEATNEEGVVEHLEGVGVDVLRLGEDGKWRYAIDDPFGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T714</accession>
    <name>A0A7W7T714_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014276">
        <property type="entry name" value="2-oxoglutarate_DH_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02927">
        <property type="entry name" value="SucB_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="565" mass="58600" checksum="024B30C47D0C7984" modified="2021-06-02" version="1">MAFSVQMPALGESVTEGTVTRWLKQEGDRVEVDEPLLEVSTDKVDTEIPSPAAGVLQKIVAQEDETVEVGAELAVIGDGDADSGSASTPVEEAAPEPQAAPAPQAAPEPEPQAAPAGGAAEGTPVTMPALGESVTEGTVTRWLKQVGDPVEVDEPLLEVSTDKVDTEIPSPVAGTLLEITAGEDETVEVGGQLAVVGSGAPAPKAPEAPKPAPVQEAPKPAPVQEAPKPTPAPEAPKPAPVQKAPKADDNNTDGGTPYVTPLVRKLAAEHGIDLATLKGSGVGGRIRKQDVQAAVEAKKAPAPAAAPASAAPAQRVAAPAADTSGKRGTVQKLPRLRQIVAQRTRESLQVSAQLTQVFEVDVTKIARLRNQAKKAFEQREGTKLTFLPFFAKAAVEALKQHPVLNASIDEEKKEVVYHGAEHLGIAIDTERGLLNAVIANAGDLNLAGLSHKIADLAARARGNKLTPDELTGGTFSLTNLGSNGALFDTPIIQQPQVGILGVGVVKKRAVVITDASGDDTIAIRSMAYLALTYDHRLVDGADAGRFLTTVKNRLEEGAFEADLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T723</accession>
    <name>A0A7W7T723_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_005120</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="7"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="337"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="175"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4967761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="456" mass="47772" checksum="0975CC00A00AC2F8" modified="2021-06-02" version="1">MTDTSADLVILGGGSGGYACAFRAAELGLSVVLVEKDKLGGTCLHRGCIPTKALLHAAEVADNAREGDQFGVKSSLEGIDIAGVNSYKDGVISRLYKGLQGLAKANKVTLVEGTGTFVGPNTVEVDGQRYTGKNVVLATGSYARSLPGLEIGGRIITSDQALNLDFVPEKVVVLGGGVIGVEFASVWASFGAEVTIVEALPRLVPAEDEYASKQLERAFRRRGIKFKTGVRFTGATQTDSGVSVTLESGDVLEADLLLVAVGRGPNSAGHGFEEAGVKIERGFVITDERLRTNIPNVYAVGDIVPGLQLAHRGFQQGIFVAEEIAGQNPKVIDEAGIPRVTYCKPEVASVGLSEAAAQEKYGKVETFVYDLAGNGKSQILKTAGGVKLVKAPDGPVVGITLVGERVGELIGEAQLIYSWEAYPEDVAPLIHAHPTQTEALGEAFLALAGKPLHVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7A9</accession>
    <name>A0A7W7T7A9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="441" mass="47016" checksum="D50C3ABFE7467F4E" modified="2021-06-02" version="1">MSDLLRLATAGSVDDGKSTLVGRLLYDTKSVLADTLDAVHRASADRGLTTPDLSLLVDGLRSEREQGITIDVAYRYFATPRRSFVLADTPGHVQYTRNTVTGASTAQLGVLLVDARKGVVEQTRRHAAVLALLGVPRLVLAVNKIDLVDYDPVVFSRIAKEFTAHALALGFTEDAVVEIPVSALAGDNVVERSARTPWYTGPTLLEHLETVPVEPDPHDAPFRFPVQYVIRPRTAQFPDYRGYAGQVAAGTVRVGDEIVVLPSGLRSRVEGIDTADGPLEEAFAGQSVTLLLADDVDISRGDLIAPADSRPAVVDEFDATVCWLSDKALTPGARVLVKHGTRTVQAIVTELRTRFDEQRLASTAGPDSLNLNEIGQVALRTAEPVPVDDYARSRRTGAFLVIDAADGSTLAAGLVGAPLPELDGVAGDARADNHALVSPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7M8</accession>
    <name>A0A7W7T7M8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="48"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="227"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="33996" checksum="F56ABE9248CFA9D8" modified="2021-06-02" version="1">MLRSTLLAASRSGAVRGLVERTPLTRPVVKRFISGDDTAAAVATTGEVLADGRYVTLDHLGEDTRDAEQASGTVEAYEVLLRRLAEVGYADRAEVSVKLSAVGQFLPKDGEKIALENARRICVAADAAGTTVTLDMEDHTTTDSTLDILRELRVDFPRVGAVLQAYLKRTEQDCRDLAHAGSRVRLCKGAYKEPAAVAFQDKTEVDRSYVRCLKVLMAGAGYPMVASHDPRLIAIAHDLAAHRAPDTYEYQMLFGIRPEEQRRLAAEGNRMRVYVPYGDEWYGYFMRRLAERPANVAFFLRALITRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z1</accession>
    <name>A0A7W7T7Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6751" checksum="5A947CA41C6A3883" modified="2021-06-02" version="1">MLSHVLVHDDGWAKIAEPDSADSFVMAVRAVTLIADHRFSADGDHGWVAGWLRCIADMVISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T800</accession>
    <name>A0A7W7T800_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="26503" checksum="FA65EADFD4B0BBB5" modified="2021-06-02" version="1">MAGKQDKAAAKEAAKARRAASKARRSQIFEAFKMQRREDKALVPLMLLCLLGTAAVAFLVGLIWDMQWVLLPLGLAVGALLAVILFGRRVQRNVFAKAEGQTGAAAWALDNLRGRWRVTQAVAGTTSGDMVHRVIGRPGVILVAEGAPHRVKALLAQEKKRVARVIGETPIYDVIVGNEEGQIPLRRLQGHLMKLPRNITNPQVDSLENRLNALANRGGAALPKGPLPQGAKMRNVQRAMRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T886</accession>
    <name>A0A7W7T886_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system sensor histidine kinase DesK</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="189"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="39983" checksum="CF30FE652089B217" modified="2021-06-02" version="1">MGSGTVGVRRMTWGMVVGAPVLVGVVSAIDLLTGRYGPVMTAVLTVVLLVVFGQYLRYTPHVMRGMDHRVGPDLEHVATFAVAVLGWALVVRVQPISAVWSVLPALVVSYVVTVRPGWSRWLLVFGGTAIVVAAGGVLGRPSLFDGVLMPGLSMLVYTGSLLTQLWFWDVVLRLEKARETERALAVAEERLRFAADLHDIQGHHLQAIALKAELAERLAGRDDEQARRHARDAADLARTALRETRDVVQGYRRASLGTEITNAVGVLRAAGIDAEVTGDAAAVPPPLQPLFGALVREGTTNVLRHSRARRCRLEIVVVDGRVDVRLGNDGAGAPGEPGAGIAGLRERFAAVGGRIEVEADGEDFTLIGQAGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M5</accession>
    <name>A0A7W7T8M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="25"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26669" checksum="10B17A8B54E1A945" modified="2021-06-02" version="1">MTTRDTFEQWTAAEDFDALLSLGNEVTYESGRHLMWQGDVADCVMVLRSGYVQVLDRGDDGLRRVLGFRKRGELLGELAYFGDGRRTASVIAYGLVTVVKIPGRRFQAFLDRHPRVYQAIVRMLALRLHTVERRRAGKAVARVLRELVDLAQAFSDDRDRKVVLPVTQEVLGQLADMSYPSAQRAVRALRRRNLLDPGSRKLTVPCQGCLRRAAQAPPDYGNPINGCGGSPTCPQRVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V6</accession>
    <name>A0A7W7T9V6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="222" mass="24025" checksum="A74D8A07EE90AE93" modified="2021-06-02" version="1">MSVIRVVLADDQVLVRAGFRLLLDTEDGFEVVGEAGDGGQAVARAVELRPDVVVMDIRMPGVDGLEATRRIAAEAPDVKVLVLTTFDVDEYVFEALRGGASGFLLKDTEPVELLHALRVVAAGDALLAPRVTRRLIEEFAARPEHRRPEPGALAVLTVREREILALVAGGLSNEEIAAHLVISPATSRTHVSRVMTKLGARDRAQLVVLAYESGLVNPRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA04</accession>
    <name>A0A7W7TA04_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13890" checksum="20754E7F50D36AEB" modified="2021-06-02" version="1">MVELEAWYDVEADDPAILTTAAEVDALLDRMVSDSLAFDVPPLVELSFADVVAYVGVDAKRQRGFITYNDTISATDDPDSTPVEYDYMGNVREIPAYAEIPLSDVRTATLDLLTGRPSEAITWRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA25</accession>
    <name>A0A7W7TA25_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EndoU_bacteria domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029501">
        <property type="entry name" value="EndoU_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14436">
        <property type="entry name" value="EndoU_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EndoU_bacteria" evidence="1">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23197" checksum="9F635A5184BE0084" modified="2021-06-02" version="1">MTSLGEVGKSLRRALDLVAQAIAHHEQAATLVDEAHALLMTTLGDARHTAFATTAKAIRATVDDLRAITALVENYLTSLGLTSTPTAWDAIQEGRTPPTFHVTEARRVHILDGDGDDENGGHAPGTGMPFKKEFPAHWSDEKIISAILDVARNPDSPPRARWNPDSWQVRGEREGVVMDVILGPDGAVWTGYPRRGRGVIHNDRYGNPTDPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA74</accession>
    <name>A0A7W7TA74_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polar amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030518411" evidence="4">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="5">
        <location>
            <begin position="47"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="6">
        <location>
            <begin position="47"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="29257" checksum="85BCD8E534EA6A2F" modified="2021-06-02" version="1">MARRTRHTAFALIPVLALTASLAACATKLDTAPVDPAAGIKLVEAGKLTTCTHLSYKPFQYSEGDKTVGFDVDLVNLVAKELGVTQKIFDTPFETITSGTTFSTNKCDVAAAGMTITAERAAVIDFSEPYFDASQALLVKKGSGITDLSGLKGKKIGVQQDTTGEKYANDNAATHGYTVIQFEDLPLMEAAVRTGAVDAAINDNGVLFDYAKEFPETEVTKEFDTGEEYGIAVRKGNTALLTKVNDVLKKAKTSGEYDKLYEKWFGKKPANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAK9</accession>
    <name>A0A7W7TAK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="86"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="203"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="462" mass="48796" checksum="B9DD0E352B810590" modified="2021-06-02" version="1">MNAVTTHRSAEEIGRTEVGPRPLPELGEQRAAADLSSVDTVLDNGLRVIAVRRSSVPVVELRLRIPFADPADTSVGSAHAARAEVLANTVLTGTATRTRVDIDTELALVGGELDAVVDPERLALSGNALVSGFDTLLDVLRDVLTGATHPADEVERERARLVERIRLARSQPNVIAREALQRHLYGDHPYAKEMPEADEVEVVTRDEVVALHAAAVLPRGSVLVVVGDVEPADAVRAVDGALGSWTGEGEAVALRPLPAVEGGDVAFVHRAGAVQSQIRLAGRGLDRTDPRYSALQIANLIFGGFFSSRLVENIREDKGYTYSARSHPEFTPGGAALMIDADTASEVTAAALLETRYELGRLSLVSPTEAEVDTARRYAIGSLLTATSSQGGLASFLVNLAGLGLGIEWFTGHPERLAGVTVEQVAEVALEFFAPSAFTGVVVGDADVLAPRLRALGGVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAZ0</accession>
    <name>A0A7W7TAZ0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_006641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="132"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="251"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4969282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="39581" checksum="4F184BC707B020E0" modified="2021-06-02" version="1">MKIRVERDGLADAVAWVARSLPSRPSIPVLGGVLLDAGAEDGSGDALTVSGFDYEVSAQCGVPATIADGGRALVSGRLLADITKALPNHPVEISVDGARMSITCGSAKFSLPTMPVEDYPQLPNMPQLAGELPGEVFGEAVAQVAVAAGRDDTLPMLTGVRLEIGDGKLTLVATDRFRLAMREFPWEPNSELGDVAVLVPAKTLNDSAKTLGASGAKVELSLAAGDGLLGLSGSGRRTTARLLDADFPKYRQLLPSEHSAAAVIEVDALVQAIKRVSLVAERGTQVRLEFGDTGLKLSAGGDDEGSAEEELPVDYEGDPVTIAFNPTYLHEGLQAVKTPKAHLSFTTPSRPALLKPVDEDGNVAPGYLYLLMPVRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTF9</accession>
    <name>A0A7W7WTF9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4395 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025508">
        <property type="entry name" value="DUF4395"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14340">
        <property type="entry name" value="DUF4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4395" evidence="2">
        <location>
            <begin position="7"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15015" checksum="0AD02C9774D42D06" modified="2021-06-02" version="1">MPKDSPVDPRGPRFTAWTTAVVLVVVLLTGAWPVLAAQAVLFGLGAFVSLNANPWTAVFRSFVAPRLKPTAEREETAPLRFAQGVGFVFAAVGTIGYASGLTALGVVATSGALVAALLNAALGLCLGCEMFLLLRRFTPALVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTJ7</accession>
    <name>A0A7W7WTJ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bact-PGI_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bact-PGI_C" evidence="2">
        <location>
            <begin position="200"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="37303" checksum="585CDDB135BD5EA9" modified="2021-06-02" version="1">MLDDSLLDDQSRLTDADHGGLLRAAARAGAQVRATTEAADELGVPRVFRERPRALVLVTRPGVAPGVAGLVSALLGPDCPVPVVVTDDVPTWVGALDVVLAHTEDPGDHVLAEAVDRAARRGARVLLTAEPDGPVAASAARHALLIPPRVPVPQGFGFARAFTAWAVVLKALRLLDVDLGLLADELDREAERAHPMHESFVNPAKTLALRVAERTPVFWGLDTVATAVAGHGAHVLATYAGVVSDVVGYPQASTRSVLHRRAVGATSGADIFADPDDEVDQPLRVVLLAVRKGRQAEYARRVAADALAGADVLEPAEEVTGDDAVCAAVLALRFELAALYLGLAAGTLGGPGRYAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTV2</accession>
    <name>A0A7W7WTV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA threonylcarbamoyl adenosine modification protein (Sua5/YciO/YrdC/YwlC family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="19759" checksum="4CD713BDB0D32A71" modified="2021-06-02" version="1">MVVLPTDTVYGIGCDAFDAKAVRYLLEAKGRGPDMPVPVLVGSWTTIDGLVLSVPRDARALIEAFWPGGLSLVLQHAPSLTWDLGHTRGTVMLRMPLHPVALELLRDVGPMAVSSANKSGFPPATTAAQAQQQLGEEVGVYLDGGTSGENIPSTIVDLTGPEPLVLREGAVAVSQVREVLGREVEVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU82</accession>
    <name>A0A7W7WU82_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011102">
        <property type="entry name" value="Sig_transdc_His_kinase_HWE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00911">
        <property type="entry name" value="HWE_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="299"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="495" mass="54163" checksum="AFC5DF5B3D09D4E7" modified="2021-06-02" version="1">MAHLSTLTDLLAEHTGLSGRGVDHLQLLVAEWQLLGDLSFADFLLWVPLDDTTFLCVAQARPTTAPTAHPEDVVGSMVVVDEHPQLRRAVAERRICREEDPRWHLGVPVRREAIPVTHDGDVIAVLSRNTNLAVPRVPSPLEISYLGSAADLCQMIADGTFPTTEPSPDVHTSPRVGDGLIRLDASGAVVFASPNALSAYHRMGHASDLIGVHLAPLTRSLIGDPFDATEVAQRIRQALDGQPSMRIEAESRRGAAVLFRALPLRPRGSAAGALVLCRDVTEVRRRDRALMSKDATIREIHHRVKNNLQTVAALLRLQSRRTSSEEAREALAESVRRVTSIALVHETLSMSVDERVDLDDVVDKVIPMMSDVAAADSQVSVRREGPFGIVPAELATPLVMVLTELVQNAFEHAYSPGQRGEVVVFAERSAKWLDVVISDDGRGLPPGFSLERTDRLGLQIVRTLVESELRGSLSLRRRPEGGTEAVLRVPLRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUB6</accession>
    <name>A0A7W7WUB6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="16" type="ORF">F4559_001489</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="58"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4964130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="36813" checksum="6E8EC94132DCA2C2" modified="2021-06-02" version="1">MTAAPEQVDVLGTAREQVLERGVGLSEEQVLAVLRLSDDRIPELLALAHEVRMRWCGPEVEVEGIVSLKTGGCPEDCHFCSQSGQFPSPVRSAWLDIPGLVRAARQTADTGATEFCIVAAVRGPDKRLLSQVRDGIKAIRADGNDIQIACSLGMLTQEQVDELVAMGCHRYNHNLETARSHFPNVVTTHSWEERWETLTMVREAGMEVCCGGIIGMGETLEQRAEFAVQLASLEPDEVPMNFLIPNPGTPYENYPVVEGPDALRTIGAFRLALPRTILRFAGGRELTLGDLGAKQGMLGGINAIIVGNYLTNLGRPAQQDLDMLGELSMPIKELSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG4</accession>
    <name>A0A7W7WUG4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="6" type="ORF">F4559_001578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="31245" checksum="2E6BBCF6B6E81A92" modified="2021-06-02" version="1">MIREPLGAGLNRTWDVDEVVVDTNTAFQHLVIARTAQGLSLFCDDDRQSTEFSQLTYHEALMVPALLLADQVDRVLVIGSSEGVVCQMAVAAGASVVDHIDIDEQAVKLCAEHLPYGYTNDELAAAERGDGAVRVRYIDGWEYIRTTSERYDIVLVDLPDEREEEAQHNRLYGEEFLGMCKALLNPGGVVVTQAGCQTMWRNNTLVRSWQRFHSVFDTVAYYGSDEHEWAYLFGRADKVEDPTALMVERLPKGGYQPETIDELALRGNSIAPYLVRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUK4</accession>
    <name>A0A7W7WUK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidyl-tRNA synthetase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="1">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="438" mass="47854" checksum="8FABB8E3119C28A1" modified="2021-06-02" version="1">MVDLFGRELRKRQLVVAVLAKVVRLHGYEQVEVPLVERATSFSEEVVGRSPWPEWDSRGCFHLRAPDYPSSYEDAPDHTDVLLVPEGTISVTRWIGCRLAESPDMIFPVKLFYDMPCFRNEVVAELTGTKRRQFTQFGLEILGAEPGNSDVEAVYLITRCLEELGVAAGGTRVRVGDVGVFNRLVELSGLGPDAAIQVKEVLDAMAECKAGKAPERASGLLGRLAGVLDAGGVSRLPHDVWMGLAHAGDSVSFLRALHDSVIDERLDDLARLVHVLEALGVRVETDLCVVRSHEYYTGIVFEIDVVTEEYSHVEVGGGGRYDKLVGHFVPDGGVDRIPATGFAFGVERLVELLDHLDLLPAHRVLRSSIGLSESSAEKLVASGPGAQEYLSAVRIAAADRAAGHPVDIYLGVPDQVERYAESRKIPQTVSCEPQRADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL6</accession>
    <name>A0A7W7WUL6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein F4559_001306</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="13134" checksum="7DCBC1485F47334E" modified="2021-06-02" version="1">MNMALGKRGEDVACEWLEREGLVVLSRNWRCKEGELDIVATDGTELVVCEVKCRSGTDRGSPLEAVTPEKLDRIRRLAMRWLSDYRVGWVRIRFDVIAVEWPPDGPVSLRHVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM9</accession>
    <name>A0A7W7WUM9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_000932</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="342"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4963573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="49623" checksum="0A2031421FB4B7F3" modified="2021-06-02" version="1">MSAHFDVVVLGAGPGGYVAAIRAAQLGLRTAVIEERYWGGVCLNVGCIPSKALLRNAELAHIFQHERKVYGIEVDGEVRFDYGVAFERSRKVADGRVKGVHFLMKKNGITEFHGRGTFVDANSIRVGDETVTFDSVIIAAGATTRLLPGTKLSDRVVTYEEQILERDLPGSIVIAGAGAIGVEFAYVLHNYGVKVTIVEFLDRVVPLEDEEVSAELLKRYRKLGIDVRTGTKVESIDDSGAKVRVTVSKNGVEEVLEADKVLQAIGFQPRTEGYGLENTGVALTARGAIEVDGRGRTNVPHIFAIGDVTAKLMLAHAAEAMGIIAAETIAGAETQEVEFVMIPRATYCQPQIASFGYTEKQAREQGFDVKVAKFPFTANAKAHGIGDPGGFVKLISDATHGELLGGHLIGPDVTELLPQLTLAQQWDLTVHEVARNVHAHPTLGEAVKEAVHGLAGHMINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB3</accession>
    <name>A0A7W7WVB3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="197"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28080" checksum="5CA4C849AC75C452" modified="2021-06-02" version="1">MGIAVRGSSAAPADVDRFRRLLTAVRGAGVTVVGATGTGREEVVDACTAAARELGVPVLRGRVVAGTPYSGFAEAFGQCDVGPLTDFGRHAALLLRGLFRAMATPGWATEALGLADTEHTRLHRAVGAVLDAATGPDGLVLVLRDAHLLDDDALALLDHLTAESRRSRVLVLLSHAPDERLAGLTGPPRPTAEVVRLPVDRATPTRRERTVLAALAEGLTADAIARRLDISPRTVHRHLQHLYRKLGTTDRLATVLRAQELGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ7</accession>
    <name>A0A7W7WVQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="87"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34992" checksum="2EE4F52028F26E8D" modified="2021-06-02" version="1">MGNAEADPDPSLPMSRRTLLRGTGLALGGTALANGTADAHPPGVPVPGPGSPVRPIPVPGQVPATEGLFEVPGARLWYWDTGGPGQPVVLLHALSGSGESWPYQQPYLARAGYRVIGYSRRGYAHSPVRDPDDPRTGIEDLHDLVDFLGVGKFHVVGVAGGGWYAMDYALNHPDRLRSLVIGACVLQVQERDYQDMVGRLRSPEVDALPVHFRELGPSYRAIDPEGVAGWLDIHHRAGPDGIVQPRATTLSWAVIERLTVPTLLLWGDGDPFTAPPVQRLLAGHFRRVRTVVANECGHNVHWERSDVFNPVLRNFFRANRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX7</accession>
    <name>A0A7W7WVX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAE1 family hydrophobic/amphiphilic exporter-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="947"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1031" mass="106663" checksum="99AB61280381F0DE" modified="2021-06-02" version="1">MSVLARLSLANRSLVGLLSLVVIGFGVLTLPSIKQQLFPSIELPAAAIVAPYPGAAPDLVDRQVAEPIQSAVRGIDGVEEVLTTSAESLATIQVMFTYGTDIDAAVNQLQQAVNRLQPRLPEGVEPTVAQGSTDDIPVVALAATSGDDDIATAARLRAEVVPGIEEIKGVREASVSGEREREVTVTVDYGKLGARGLDPQALTAALRGAGAAVPAGAVERGTQSLTVQIGGPVTSVDALRDLVLTSPNGPVKLREVATVESAPAALAVLNRTDGKPTLGVVVTMNADGNAVEISKAVRAKLDEWGKAADSTLTVAFDQGPEVEKAISGLTTEGLLGLLFAVVVILLFLMSLRSTLVTAVSIPLSVVVALIALWTGDLSLNLLTLGALTIAVGRVVDDSIVVLENIKRHLGYGEEKQRAVLDGTREVAGAVTASTLTTVAVFLPIAFVDGIAGELFGPFSITVTVALLASLLVSLTIVPVLAFWFLKRPVVSDDPAAAAEAKRLAVEKERRGLLQRIYVPVLRFATRRRLVTVLIAVLIFIGTVGLAGQLKTDFIGDSGGTALQGTQTLPPGTGLKARDDAARKLEAVLADTDEIETYQVTVGSDTSMAAFGFGGDGNTRVQATVREGTDLEALGTRLSDKMKGVEGAGEVKFGAGASGFGSDGIEVLVTADDEKSLREAADQVQKAVEGTPGVAEVDNDLAVSAPRVQVVVNEDAAAARGLNGQVIGQFAAQALRGSPVGELPIGEGSQRIVLRTGTAPADVDALKALALPGGVTLGQVAEVSVVDGPVQVKRTDGERSTTVRAKVTGADLGAVTADLAKRLDALDLPGGADQEIGGVSQDQADTFADLGLAMLAAIAIVFLIMVATFRSIVQPLILLVSIPFAATGALGLLLVTGTALGLPSLIGMLMLVGIVVTNAIVLIDLVNQYRAQGMGVTEAVIEGGRSRLRPILMTAAATIFALLPMALGVTGEGAFIGKPLALVVIGGLVSSTLLTLVLVPTLYTMVEGRKERRRARREAKREQAPRREPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW63</accession>
    <name>A0A7W7WW63_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26957" checksum="E7DA07E5270C127E" modified="2021-06-02" version="1">MYDLVTPLLNAVAGGPCAIHHGYWADGGASSWEDAADRLTDLVARRTPLGPGTRLLDIGCGTGQPVLRIARDHDIHVTGITVSRVQVELAVEGAHGLRAEFALADAMSLPYADNAFDAAWAVQSLVEMAEPDRAAREAFRVLEPGGVLVVTDVVTRGATPAPDERWPTGLRKCAAGEVVGWLTGAGFEVSSCEDASAGTRYFLPKFASALAGYRRTIEDLYGPHVAEWAAAVGDHENYADEMGYVVVTARKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW70</accession>
    <name>A0A7W7WW70_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic divalent cation tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11589" checksum="EAA0E41132890F35" modified="2021-06-02" version="1">MTEFVQVTTAAGSREAAFVLARSAVGARLAAGAQVVGPVGSVFWHLGELGEGEEWAVVLKTTTDRFPGLRDHLVANHPWTNPEVTATAVVDGTPEYFEWLRRTVAPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ6</accession>
    <name>A0A7W7WWJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="44494" checksum="F8E33C7C6538C78D" modified="2021-06-02" version="1">MTSAAAFDRQIPDTAARKVEFISLSHLNPSTELDPIPTRGIDLAYFRTYVRALEEGGYDYTLLPYGAGGADSFVVASAVGQLTERIKPIVALRPNTTFPLVGAQKLATLDQLTEGRAVVHLISGGSDAEQARQGDYLPKDRRYARTSEYIDLLRRAWTEPAPFGHEGEFYRFDDFGPGFAPYDAPIPISLGGQSDEAFRVGGEKADIFSFWGEPLDDLTAEIDRVHAIARAAGRTTLPRIWVTFRPIIAKTDELAWKKAHEYVARIADTFGKSAYGRQSFLKGTPQNVGSQRALSFADKADLYDRALWTRTAAVTNAAGASTALVGSPETVAAAILDYVDRGADLVSIRGYDTLADAVDYGRHILPLVRQEIAHREATGRRGTLQADHLGNYTEDYRRHATADHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK6</accession>
    <name>A0A7W7WWK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27565" checksum="97425463E613CB4B" modified="2021-06-02" version="1">MPRAAELTRLLENGPFPAALRAAIDASGLSLGRVRHRLVLRGVTVSVPTLSLWQSGRRRPERPESLRALRHLEHVLDLPAGSLGALLGPPKPRGRTADSAGQVSLYDHVRVSREGVVAHSRLVLRGPAARWSARWSLATDAAPTIRVVRGGRVGRVEHDLDDGRLTAELVLTTPVTADSSAVIEYEAAFAPAQSDHVRLLDRPIRDYQVEVDFTDPPAECVRVDDGRPLLPDQDGAVHIVLADAVGRVGVRWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ7</accession>
    <name>A0A7W7WWQ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="2">
        <location>
            <begin position="151"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Lant_dehydr_N" evidence="2">
        <location>
            <begin position="728"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="949" mass="101733" checksum="CF6488D7DB415F1C" modified="2021-06-02" version="1">MVTPPEGRSPAGPWRVADAPVVRLAGLPAALLTTLRCGVTAAAVDLLDAETAWLAREGAGLADVLHDLIGARDDGPRDRPALIGLRRAVHRGRVPGRREADVLDTLPAAFAARVRAWCERTAAHRVAVAGLDDLLTADRERVVGVLRDTAADPLVRRALVLASPELLAELDRWVADPRRVPQAQKLVRLVRFLVRATAKTSPFSTFLDTGLGVWDGTDPTPSRRCAVLELDGSLLHRLRTAVAALPAVTTVEADPSAVVDGDRVVLLGASPAEPTGTLPASPAVLRCLDTARSGVRVPELVRDLAAGTGGDHDAAARFVARLLDTGLLRPRSPVPDLEPDQLGRLSEALTGHPDLGRLVDAVRVPLVADIPPAEVARHRARLDDLGTAWSALADRLDLPGEVRVHETVVATGPSRALDPTTWTPHLDDLDVVRRWLVVFDWKVPIRLAVAEFVRTRFGAGARVPLPVLHREIRLAVAHDRSPLGDVLRALLGPTARPWFADLDSAAVPRFAELRALRAAAGAPADREPDVEGPKSGGPDHRITSASDPGTAGSGSARLDREHPAPEDRHRRADVPDRTCPRPAGTHPDPAGGRWTAADPTAEESVGTEPVGAERIARGRNGPEWTVAESAGPGGTNAPQPDIVRIDPAEVAAQIRSWPAWLTGPASVGCYLQRADDRLVLNAVHAGHGRQTARVRHLLDRAGAPVPARAPDPRVAEFTGLFGSTLNARVPTARYEIGYPGTTGAPGGERLPVADLVVRHDPDLDLVGLWHADTPVVPVHPGMMADFHLPPLARFADRAFNPAYQVHPSAPPLVPHDATPDAVVRLPRVEIGSVVVRRARWTFPIDRVPPRTAAGSDADHLLRLAAWRREHGVPARCFARSWGEETAVSVAKARKPSYVDFGDWFLVAAFDRRLSGRSTVLLEEALPEPGADGTHVAEYFVELDDREEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT6</accession>
    <name>A0A7W7WWT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="671" mass="72516" checksum="037A8F7686070C79" modified="2021-06-02" version="1">MKRSTVNRVDGVVNGQLVQAGTVVQNTVNAPRTPDDILADTADRLAHAVRTRWRREEEQRRVRDPFPLPVRWRVADDELTDHWANIRHKPHGVRAGPLALADRLDRVVDAYRRIPSGRLVVLGRAGSGKTVVALRLVLDLLDARTADEPVPVLVGLGSWNPTTTPLHEWLARRLVRDHPGLAAAGPFGRTLADALVEAGRVLPVLDGFDEIAPGLHRAALEALNDTTGPLVLTGRHAEYSRAVTDGDVLTCAAAVELADLEPTDLDDYLPRTTRRTGQSSTAWDPVLDAVRRDPDAPLARVLTTPLMVGLARAAYSDTPDRDPAALLAFDTTQAVEDHLLDEFLPAVYRRSGRDLDRVRHWLRHLAGRGRRDLAWWEAEACLSRACRAVIVGLVVAATTGLVMALVDLVLYGLVANGEAEPGIGSGLVNGAVNGLLVGMAFAAVAAVRADRVEPARTRFGGCGRGPGRLALSRAVLGVGIGALFGLVDGMSFGVLERWVLGVPDGLRIGLDTACASALVFGPAVGICYGLLTWSESPLDVATAVTPTDLLRTSRANVLVPLLTIGPLFGLLVMLGFRLIVVYLYRLPVAEEFSDVRSGLISGLAGGIGYALTLTAWGRWLVFGRLWLPLTGRLPWTPIAFLDDAYGRGVLRRAGAVHQFRHERLREHLARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU4</accession>
    <name>A0A7W7WWU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="33625" checksum="5377144668FCB187" modified="2021-06-02" version="1">MDTLGAVAHRGGLLVRRPELTVGVKLAVARTTGMDWELIARRPPDRRSATRRQQDVRLVPPLEPAPRRLLPTADEGLDLRFGTLDDAGRAHWHFPVHSSAGTGDHHEGPSHDVVFRLPPAFDRITLVFAWPEIGFPETTITLPLPDRTAVDRATRSVWDAPVTATTPVPHLARRTAAHLRANAEEGIGIAPPQVLHRGEHAAIVLTHLAAVDRVLSFGLSGHAHGDTARTIARTAFGPPHGTDPSPTVAFVADGEAFQVQAYSGTSFGSGAVHTDRQDFFVPRPHDDVLDLLVAWPIVGLAEAHARITPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX34</accession>
    <name>A0A7W7WX34_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="33776" checksum="A9598756C72C5ED9" modified="2021-06-02" version="1">MLTGLRVTGLVLCTGVLVLFALLSIAVGARSVPLSTVVDVLFDPDGSYDALVVVGQRVPRTILGILVGAALGLAGALMQSLTRNPLADPGLLGVNSGAAAAVVSAISFLGLTSPLEYVWFAFVGAAVAAVVVYLLGSSGRAAGPVRLALAGTAISAVLVAYTYAVQLADDKALDQFRFWIVGGLAGRDLDILTRVGPFLAVGLVVGLLLARPLNVVALGDETGRALGANLGRVRLTAAASITLLCGAATAAAGPFSFIGLTVPHIARSLVGADQRWVLPYSALLAPCLLLGADVLGRVVVPPSELEAGLVTAFLGAPVFIMLVRRRRVVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX63</accession>
    <name>A0A7W7WX63_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031795">
        <property type="entry name" value="Zf-HC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16827">
        <property type="entry name" value="zf-HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="10315" checksum="B8AC2759786A7CC8" modified="2021-06-02" version="1">MKREFRWLPYEGRRHAVRAVLVAHEVGETLCGVPLVVPATSPYERWCWPTCPGCDSAWRSHEGIPAFPRDGRAPGRYTPRRRQARDQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX82</accession>
    <name>A0A7W7WX82_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="15905" checksum="4BA581B20CE12362" modified="2021-06-02" version="1">MIDIWTIVRFLHVLGAIIWVGGQLTITIVVLPPVRRMLSADDRAGMLRTVGKRFAIITMAVFLPNQVTTGVLLAWQHGVTWATLLQPGYGRILAAKLLLFTLVMVAAALHGIAQARHQPGKARAASITALVGSLGVILLATALAESTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA4</accession>
    <name>A0A7W7WXA4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="516" mass="54074" checksum="7D37358C376D8418" modified="2021-06-02" version="1">MSTVRAAGAALPRGLLIAQAWGGLGDAVAPLSGAAGRPLARTVKLILDPLVLRPVLNPGFAAGAVAMDHVDALRDRIVAAGPVLAATAAWFLVVKKERRRRGITEGNPQDLYFQRCFELATAHGDPADEPDLASTRAAGVLAEVHDRAGPTVGRLRDFVADHVAELDRLLEAAWTTVPVRPGPEPETGSSATALSTGTRHVDRTASTSGDPAEPEDARGSEATGSQGLRLQGTDVCHSGSGHVESAAVSRSGGRTAVLVPGRTASLQVPTPPPGDSRAGSLDEVLAARIGAFLDGCATRPDAGLFGGLLADRVGSSAAVGHRGDGVAREQGLTDLPRPVRPVVGDTASKKSLPKPFDRSIVERLFGALSGSGDRDGLADVPDLVRAEISRSASPWQLGTEAARVTIALGRAAAGGLTGDAASTDAAARLRSRWEREAYVHRVLRMPDKVPGEVRADVLGVCQAYLRRLWVRVHGRELRGEDVGAADVWDLLDGVLRSVVLDQRDRLRSALERRDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE5</accession>
    <name>A0A7W7WXE5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="172"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38775" checksum="9EA0189A22D9E644" modified="2021-06-02" version="1">MVDVLRSLWREPRPGPGPGPVWWDWVLVAVLVPVALVEGLTRHGVWSAVVAAGLVFVLPWRRRAPFPVVVIAFGGCFVLSLVFRREFPDQGVLAYLLLLPFSLFRWGSGRDAVSGAVVMVGKVGLSASLGYLAWGDALAGVGILAAAMALGAAVRYRVRARARELDQAKSWERERLARDLHDTVAHHVSAMAVRAQAGIALAATDPGAAVDALRVIDVEAGKALDEMRGIVRILRAVDPVEGTPRFDDLGTLASRGTPVVDIEVVGDATGLPAPVGTAVFRLAQEAVTNARRHARDATRVHVRVDVDAAVVRLRVSDDGRASSSATPGYGLVGMVERATLLGGTCVAGPDDGRGWLVAAELPKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG8</accession>
    <name>A0A7W7WXG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7659" checksum="CE123619838D7898" modified="2021-06-02" version="1">MAIVVRIDVELAKRKMSVGEFAERVGLTPANVAVLKNGRAKAVRFSTLEAMCRVLGCQPGDLLEWVEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK1</accession>
    <name>A0A7W7WXK1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="18011" checksum="FD07C97E13EC7706" modified="2021-06-02" version="1">MSEKTDLIAMLARQRGFLRHTAQALTDEQAASRPTVSQLCIGGLIKHVRGVEESWLRFAVGGAELMNAGWEGQNWEDQHRMLPGETLDGLLEDYEETATKTEAIIATLDLDDEHPLPEAPWFPPGAKWSNRFVLQHVIAETSQHAGHADIIRESIDGQKTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXS1</accession>
    <name>A0A7W7WXS1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phosphonate catabolism associated alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017743">
        <property type="entry name" value="ADH_phosphonate_catab-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03366">
        <property type="entry name" value="HpnZ_proposed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="192"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="35351" checksum="2C12A3B11292B414" modified="2021-06-02" version="1">MLREHARYARWDGVGTPFALVTTPLSEPGPGEVLVRVDLATVCGSDLHTVHGRRPSPVPGVLGHEQVGTVLAVGDDVPACVDGTPVTTGLRVVWSVTASCGSCDRCARGMAQKCRVLRKYGHERWDADAPLTGGFASHCVLVPGTAVMPVPAHVPDEVAAPASCATATVAAVVAAAGPLAGRRVLVTGAGMLGVTAAAMASRSGAHVVVLDPDPGRRAQAIRFGAAETPEAAPVEDVDVALELSGRTEAAQACLGAVTIGGTVVLAGTVSPGAAIGLDPERVVRGLHTIVGVHNYRAADLRTAVDFLAAHDDLPFAGLVSGRFALDRLDDAIAAARTSTAPRQAVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY8</accession>
    <name>A0A7W7WXY8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35446" checksum="D8C16DBE84974344" modified="2021-06-02" version="1">MTITGEIRGRRPRPSPPRWRITSLEVLCAVLVLALVGQDWLASLLLDAPRVRTASTTFVAVCVQALPFLVLGVLISGAIAAFVPASALRRLLPRKEALAVPVAGVAGVALPGCECASVPVARRLMGQGVAPAAALTFLLAAPAVNPIVLVSTAVAFKDAPLMVPARFVGSLLTAVVVGWLWTRFGRTEWIAERALARVRDHDGTSRWAVFAETARHDLVEAGGYLVLGGVFAAAFKVLVPTEWLETLAGQVALGVFVMALLAVVLALCSEADAFVAVSMSTLLSPRLLLVFLVVGPAVDVKLVALQAGAFGRSFAWRFAPAVFLVAIGCAVLSGVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY00</accession>
    <name>A0A7W7WY00_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033437">
        <property type="entry name" value="DUF5130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17174">
        <property type="entry name" value="DUF5130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="16327" checksum="BF48482A2FA0CEAC" modified="2021-06-02" version="1">MASGELVKPVDPATLGVGEVVTNSGRVSAARMYTPSAPSLPFTAVQLATLDEVLTVAGRTTGLDFSVYLGALGPDSRAKAKELHAATARPAHAVVIAVSPGERAVEIVTGEESHRRLPDRGAKLAVMSMVASFKEGDLVGGLVGALRMLTDQAGHAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY56</accession>
    <name>A0A7W7WY56_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="29086" checksum="DF1B70DAE3CDED3B" modified="2021-06-02" version="1">MQIKVLGPLEARLAGVPVTPTASKPRQLLALLGLHAGRVVTMADLIEELWGAEPPRSAVTTLQTYVLRVRRRIDAAAGATSAKDLLVTRYGGYLLDLDPAAVDVTTFERLATAGRDAVDAGLPEEASALLGQALAVWRGPVLADVRIGPRLAEEVARLEEARLGVQETRIDLDLSLGRHRGVLADLSLLTAQHPMNENFHAQHMIALYRAGRPWRALESYRALHERMVDRLGLVPSERLRRLHEAVLHADSTLDVPDVNVLHTFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY59</accession>
    <name>A0A7W7WY59_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="26230" checksum="7DE5845506834E4E" modified="2021-06-02" version="1">MYPLHLPQSRLLFFFAGLVLAFVFIRISVRLIRAGVRWWPGNFTPGGTHIHHVVFGTVLLVLGAVTGIAAPDDLHELRVSAAALLGVGTALVLDEFALLLHLRDVYWSKDGRLSVDAVFLAIGLTGLLLLGARPLGYDELYGEGVGVRIAVVLVNLGFAIVALLKGKVWTGLLGLLVPVLPEIGALRLARPGSPWARWRYAEGSRKLRLAYRREARVRQPLIRVKIRVQEFISGRHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY71</accession>
    <name>A0A7W7WY71_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16541" checksum="2C9F022DFC66F092" modified="2021-06-02" version="1">MRHDPPAGTDPHRYLADFEQQLQQARQRIEAVNAAFRAARTTSTSRDGAVTVTVASGGRIESLRLTPKAIELGYATLAATITDTIRTAQVGAARMIEDAVRPVLGDGEGMDFLREQVERGITAIDSTAAPTDRPARKTSRNDDDYYDGPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYC4</accession>
    <name>A0A7W7WYC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="29919" checksum="87DF2E9E90872B8A" modified="2021-06-02" version="1">MHTLIGAPVLGFDLTRLPGGSATAGILTALLGFDTAGMAALASWVRTAPARLAHARHRAEAGEANRPPVSRLVGLDPEALERAPIGNLSTLLHCVRTDVLVPDYGNGEDGPVDGDLVEVVCDAIRASYLSELVSAQDRRTLSARWVSLRRLLPEPGGTRPWSPSVEALLTRVRGVTRTESAALLAAAERMRSERRDWASAMHSATWAVHLSDRVRSTAAAQFELVQAVDVAGIPVGDRAAGVWNVLSGAVQALSVRDMVDGSTAHELLVPCLAALGPGWLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYF5</accession>
    <name>A0A7W7WYF5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">F4559_005310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="26"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="609"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="809"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="814"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="527"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4967951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="876" mass="97394" checksum="932D764B4CD4FC5B" modified="2021-06-02" version="1">MTETPTAAQRPELPSAWNPAEVEAGLYERWVERGYFTADPGSDKPPFAIMLPPPNVNGSLHMGHALNHSVMDALSRRRRMQGYEVLWLPGTDHAGIATQTAVERALASEGQSRHDLGREKFVERVWQWREEVGGRILGQMRRLGDGVDWSRLRFTMDEGLSEAVQTIFKKLYDDGLIYRAERIINWCPRCRTALSDIEVDHSDDDGELVSIRYGEGDRSIVVATTRAETMLGDTAVAVHPEDERYRHLIGTTVEVPLTGRFVPIVGDGHVDPKFGTGAVKVTPAHDPNDFEIGRRHDLPALTVMDGLGNITVKGPFEGLDRFEARPAVVAALREQGRIVAEKRPYTHSVGHCSRCDTVIEPRLSLQWWVKVEPLARAAGEAVRDGRTTIHPPELAKRYFDWVDNLNDWCISRQLWWGHRIPVWYGPDGEVRCVGPDEQPPGEGWTRDEDVLDTWFSSGLWPFSTLGWPESADDLARFYPTAVLSTGYDILFFWVVRMMMFGLYALDGKQPFDHVFLHGLIRDQHGKKMSKSRGNGIDPIDWMDAYGADATRFTLLRGANPGSDLALAEEWAAGSRNFTTKLWNATRFALSNGATVEGGLPDRDALTDADRWILDLLDRLVSDVDGQFEAFQFAKLAEGLYHFVWDEFCDWYLELAKVQLAEGGARADATRSVLGHVLDVVLRLLHPLTPFVTETLWTTLTGGESLVVADWPKPSGVARDEVAATRIEGVKKLVTEVRRFRSDQGLKPAQKVAGKVRGACCVDLLDHVPAVRSLTRMTEPEDGFAASVSLEVGLPAGAVKVELDLSGAIDVVAERKRLAKDLAVAEKERAQCEGKLNNAAFTAKAPADVVEKIKARLAAADAEIDRIHARLETLPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT7</accession>
    <name>A0A7W7WYT7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="369"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="648" mass="69500" checksum="91D781C9AD4C7675" modified="2021-06-02" version="1">MALAESLLAWLHGWAGVPLCFGDWAWTTTAMGALIGVLPTVAALLSIGVRRIVGNSYGPITGGLFAVLGVVSTLVLPWVLFSNTFHALDDRTLPGIGSLDESPCVAFTQQEYLVDAPSIYRAITNQEGALFLGAACVTALLALLCLLFVMTQAGSAFRLGPSWPRRVFWPPFAFLLVAVSALPVTMVGHLLLGFFPIALIGSLVVRVFGLTTAMLNRPGRDRGTPPAPQGQPHQPSRPQQQPQQQPRQSNQPPPAPLGPGQKPPPYQPAQIPPYQPVPPYRPTPPQRHYPPTRVAEVPPVNRPQQTPPPTRVDQPSQQPAPTRVEQPSQQPAPLANTPGPLPFGPESGNHEAPSSPVSGKVWNPAGGRFRRVRQLGSGGFGTVWLAVDTQLDRTVAVKLAHAPDNDTEQRMLREARALAAVRHPNCVRVFDIVQDPDGLAIVMEYIDGAALSDVVVKNGLLQDAFAARLWVTMADALAAAHDRGVLHRDVKPSNVIVDGEGNAHLIDFGIARAKGDTTLTATGMMVGTPDFLAPETARGENATPASDAWQLAATVSYALTGHPPRGSRENPISSLMAAAKGEPCVKLPQLSAHHRLLTNALDQDPKRRPTLAQIRGELTSYLSRTGVSKEGPVTRMIDRPEPPTRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ93</accession>
    <name>A0A7W7WZ93_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CopC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030835757" description="CopC domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="5">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="18199" checksum="F001F35F8186FD3F" modified="2021-06-02" version="1">MRHAVSLLLAFLVAGGVALATAAPASAHNVLISSDPKDGATLESGPKEITLTFDQPVQGGEGFNTITVKAPDGTQWQGDGQPTVKDNSVRFPIRTLGDAAEYTVTYRILSADGHSVPGSLKFTTTKAGGGTPAPVETATGAESSGGIPIWVWIVGAVVLLGGGVFFALRGGTPEDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXA7</accession>
    <name>A0A7W7SXA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF2236 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="1">
        <location>
            <begin position="15"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="31557" checksum="9C9328810B7B21ED" modified="2021-06-02" version="1">MRPDAGLLGPGSVTWQLHADPAMWIAGVTSLYLQSLHPYAARAVVGNSTFREDPVGRLLRTADFVGVTSYGTTAEAEAAGARVRAVHRSLRARDEHGRTFRVDEPELLLWVHCAEVYSFVTVVRRAGFRLADAQVDRYYAEQRRIAALVGLHAEDVPGSAREMAAYFAAIRPSLRCGADSEVVYRFLRRPPLTGAVRFGLGAYEPLVGRLAYALLPSWAVALHGRRPYSAATATVALRSLRALALAVPAHVRWRYPGGHVNRAVARLGKAATPSRALLSDRSMIGKPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE0</accession>
    <name>A0A7W7SXE0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="412"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="53487" checksum="66C87310698E7203" modified="2021-06-02" version="1">MVFRSPFPDVAVPDVTLHDFLFRDRTSTRVALVDGVGGRSLTYAELAEAVERLAFLLVSRGIGRGDVVGILAPNDPYYAVVFHGILRAGATATTINTLYTDADVAFQLRDAGVKLLFSARPVDFPDTIPFSDLPELLMPGAAPEVPVSPDDVAVLPYSSGTTGRAKGVMLTHRNLVANIVQCGPLLKVESDSRILAVLPFFHIYGMQVLMNLGLHMGATVVTLPKFDLAEFLRVIQDHRTDRVYIAPPVAVALAKHPLVDQYDLSAVDTVFSGAAPLDVELAEAVARRLDCHVRQGYGMTEMSPVSHAIPDGRDDIPVGTVGFIAPNMECRFVDPASGADVGVGERGELWCRGPNVMKGYLNDPEATAVTLDSEGWLHTGDVAVIDSAGAVTIVDRVKELIKYKGYQVPPAELEALLLTHPAVVDAAVVGVQVADVGEVPKAFVVRADNSLTEADVIAFVAEHVAPYKKVRQVEFISAIPKSASGKILRKDLRGRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXF5</accession>
    <name>A0A7W7SXF5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031093966" evidence="3">
        <location>
            <begin position="34"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="30795" checksum="5CAFF9929C7E29FA" modified="2021-06-02" version="1">MRRLVAAGFLVMATLVAGCSTDLQSASAPAVDAASPPEPNAGQAKGEGQPEPAQQPAERQVVRTAEIDLRTSDVPGTLGRVKEVATRSEGFVATETSRESSGSLTLRVPAAKLDAVLKAFGDLPDVKVGRREVRSEDVTGQLIDVDTRTANQRASVERLRALLDRAGTTAEIAQIEGELTRRQTDLESSLRRQEALRDQVALSTVQVGVTRSDSSVPVAEEDAGFLDGLAGGWGALRDTVAWLLMALGAALPWLAALGIVLFLGARIRRWWRNLGQTPAPAGAVVETEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXI1</accession>
    <name>A0A7W7SXI1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ORF">F4559_000156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="92"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="146"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33670" checksum="A3BB86A03487F847" modified="2021-06-02" version="1">MADQSVSELFDPTRWKRVEGFDFTDITYHRAVDQGTVRIAFDRPEVRNAFRPHTVDELYRALDHARMSSDVGTVLITGNGPSARDGGWAFCSGGDQRIRGRSGYQYAEGETADTVDPARAGRLHILEVQRLIRFMPKVVIAVVPGWAAGGGHSLHVTCDLTLASAEHAKFKQTDADVGSFDAGYGSAYLARQVGQKFAREIFFLGRTYSADDMFRMGAVNAVVPHAELEATALEWAREINGKSPTAQRMLKYAFNLIDDGLVGQQLFAGETTRLAYMTDEAVEGRDAFLEKRAPDWSDYPYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXN0</accession>
    <name>A0A7W7SXN0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045629">
        <property type="entry name" value="DUF6232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19744">
        <property type="entry name" value="DUF6232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18488" checksum="945BD7D14975C26E" modified="2021-06-02" version="1">MARDVIDIAVRNRILWIGSRAYPLPNITMADLKEVRYRRSTALWEWSKAVAWCAAFVLVMGFIGASTTIGVGNGSYSLGELGGLVAVVIGLGVTVRLLVKLLSRPLYRLVLQTAAGSADALASRDGAAMRELTTSIVDAINDPHASFQRTINNVINQYGAGAVATQNNLGGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXX4</accession>
    <name>A0A7W7SXX4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">F4559_000298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="293"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="465"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4962939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="620" mass="66562" checksum="EF50DC11137FB05C" modified="2021-06-02" version="1">MCGIVGYVGHRSALDVVLDGLRRLEYRGYDSAGVAVLDGAGGLAVERKAGRLANLEAVLDEVGRGVFAGTVGMGHTRWATHGAPVDRNSHPHRDTTGRVAVVHNGIIENFAVLRAELEALGIEMASDTDTETTAHLVALAYAAGDTAGDLVASVRTVVRRLEGAFTLVVTHADQPDVVVAARRSSPLVVGVGVGETFLASDVSAFIEHTREAVELGQDQVVVIDRAGYTVTDFAGEPVEVKPFTVDWDLSAAEKGGHEYFMLKEIEEQPEALANTLRGHFRDGRIVLDEQRLSDQDLRDVDKVFVVACGSAYHSGLVAKYAIEHWTRLPVEVELASEFRYRDPVLDRDTLVVAVSQSGETADTLEAVRHARAQKARVLAVCNTNGAQIPRESDAVLYTHAGPEIGVASTKAFLAQIAANYLVGLALAQARGTKYPDEVAREFHELEAMPDAVARVLEKVEDVRALARSLADSKAVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEPGLPVVVVMPSPRGRAVLHSKLVSNISEIQARGARTIVIAEEGDETVRPFADHLIEVPAVPTLLQPLISTVPLQVLAAEIAKSRGYDVDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYD0</accession>
    <name>A0A7W7SYD0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21558" checksum="2469C9936EB81422" modified="2021-06-02" version="1">MQARELKISGAFEFTPSVFPDDRGFFVAPFQESAFLKAVGHPLRVAQTNHSQSRRGVIRGVHYADTPPGQSKYVHCPRGRLLDVVVDIRVGSPTFGEWDAVVLEASRFNAVYVPEGLGHALMALEDDTVTSYLCSEGFNPVAERGLDPLSLGLPWPADVEPVLSGKDASAPTLADALAQGLLPTYEACTDWYASLRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYR1</accession>
    <name>A0A7W7SYR1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SDR family mycofactocin-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031395337" evidence="3">
        <location>
            <begin position="30"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="31933" checksum="3EBD01876299F449" modified="2021-06-02" version="1">MTDEGRVSRRSLLAGAAAGVAATAATAGAAAAEPEAAGTGDLHGQVALVTGAARGIGRATCLALARAGADVVAVDIAAPKAIRLDYPLGSAAELEETVRAVRGLGRRATAVKADVRDADRLREVARQAVREFGRLDIVVPNAGITTYAPLADMSPQQFADVIDVNLTGVANTMRATIPHLVARKAGAIIVVTSSEARHGAPLLAHYQAAKWGAIGLVKAVATEVGPAGVRVSGVAPTGVRTPMVLNEATYRWAGGTGPEDLEKALRGYNTQPVGLIEPADVAEAIAFLASPKARYVSGTVLDVTAGASTRWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW7</accession>
    <name>A0A7W7SYW7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23049" checksum="59BFDA7B4AAF503C" modified="2021-06-02" version="1">MPVTRVVLAEDAGLLRESLVTLLTHFGHRVVAAVGSADELLAAVRADPPDVVVTDVRMPPTFRDEGLRAAITLRGERPGLPVLVLSQHVDAPSLGELLDTGTAGTGYLLKDRVTDGTEFVAAVTEVAAGGTVVDQEVVRRLLTRKRDPLTRLSSREREVLGLMAEGRSNAAIGTELVLADVTVSKHIGSIFTKLGLHADGGEHRRVRAVLAYLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ01</accession>
    <name>A0A7W7SZ01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="464" mass="50037" checksum="DCFB55C7B337D73D" modified="2021-06-02" version="1">MNDVRVRFSKRRSDGVLWGKSASQLVCLVVALFTAVAGAWVVAGVLVAVALVPVCGRPLVDFAPILLAQVVTRVTGEHEYRGGPFRLLPGEPGLDGPRLPGDLARLRFGAYSVGDRELGVVYEGDGGVTAAVEVRAETFALLDAADRARLVIGLGAVLNAVCRADSPIVRVQLLHRVVPDAGGDIRRDWEMHGNRDNPTASAVYEELLDDGGVRHESFLVLRLDPRRAGARITAAGGGDDGAAAVLFTEVVRVARGLRSAGLTVLGWVPPRGLGYLVRSAFDPSAKDVDPGLCHPMATSTSRSHYATDGAVHRTWWIDEWPRTEAGVPAGFLEPVLLGSTAPRTVSLVLEPLPARKAQTRIAVEAGADDARETLNRRIDRRTTRADRREAEDVHRREAELVDGFGHFRFLGFVSVTAPTTAELEVRAGLVEAALDEAAVEPRVLYWEQDQGFWAAALPFARGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ32</accession>
    <name>A0A7W7SZ32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031013056" evidence="2">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="29654" checksum="0ED19F4AF8A02C2F" modified="2021-06-02" version="1">MRIRLVVLALLLTGCASGNALPPAGSNPTTTPVEPSAAPGTSTPPGFAPVDTGFPVTATPRPIVMPGGRLGLLGDFSEAQREAARRHAFKLSTTVQAPQTPGPQEIFLPTGEKVTTRVIDAAEAYQAMTSLPDDPTAIEIVEIERIKATVTTDRGRIDIPAWSFHLAGGGEVTWPAIDPSLFWNPDNLKATTLGNGAIAQGSTLTVVLPDAPAPCPGHQPATNEAVAVESDLSVTLSVKTVGDPGECVRTQEVKTKKYKIELSKPVGNRLVLDTGGGVFDVATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ82</accession>
    <name>A0A7W7SZ82_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="5922" checksum="AB1A39B25A708A0B" modified="2021-06-02" version="1">MHWRDALTKADETLVALTAATVDVEAALRRVKHGPVFGFDRWLGVVVIDCRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM6</accession>
    <name>A0A7W7SZM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="72" mass="7475" checksum="1200FE09282B633B" modified="2021-06-02" version="1">MSGLSDLRVVIAALFGVYGVVLVVVGLWFTAADDLAAADGFNVNLWAGGGMVALALVFTAWALLRPLRVPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZP4</accession>
    <name>A0A7W7SZP4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system KDP operon response regulator KdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24816" checksum="06B698A7910F9A1D" modified="2021-06-02" version="1">MTKVLVVDDEPQIVRALRINLSARGYRVLTASDGASALAVAAEGRPDVVVLDLGLPDLDGTEVISGLRGWTTVPIIVLSARTDSTDKVEALDAGADDYVTKPFGMDELLARLRAAVRRSAVSHDVGDPVVRTASFVVDLAAKKVHREGVEVHLTPTEWGVLELLARNQGRLVAQKQLLQEVWGPAYAKETHYLRVYLAQLRRKLEPEPARPRHLVTEPGMGYRFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZZ8</accession>
    <name>A0A7W7SZZ8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="5" type="ORF">F4559_001393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="19087" checksum="B6B64F13F5452B38" modified="2021-06-02" version="1">MSSPPRGELAAQLTPVVREAVEAIGFDLESLDVNQAGRRRLVKVVVDGDDGIGLDEVAQASRAVSAALDANEHLIAGPYTLEVTSPGADRPLTRPHHWRRNRLRLVKVKPVDAVEFFGRVGDVDETGVVLLVKGGLRRVEFRTVERAVVEVEFKQPPVEELALLEGKHVEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T066</accession>
    <name>A0A7W7T066_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate synthase (NADPH/NADH) large chain</fullName>
            <ecNumber evidence="16">1.4.1.13</ecNumber>
            <ecNumber evidence="16">1.4.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_001535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="16"/>
    <dbReference type="EC" id="1.4.1.14" evidence="16"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4964176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1510" mass="163025" checksum="47703B218CE48E93" modified="2021-06-02" version="1">MIFSAIPSPQGLYDPRAERDACGVAMVADIKGRRSHGIVVDALTALANLEHRGAAGAEPTSGDGAGILLQLPDAFLRATAGFDLPLEGAYAAGIAFLPEDVDERARAVTIVERVAGEEGLDVLGWRDVPVDPDHAGVGPTARSVMPHFAMLFVAADDRTGVDLDRVVYALRKRAEHETAAAGVGVYFPSLSARTIVYKGMLTTGQLPAFFPDLRDERLTAAIALVHSRFSTNTFPSWPLAHPFRFVAHNGEINTVRGNRNRMRAREALLDSDLIPGDLTRLFPICDPEGSDSASFDEVLELLHLGGRGLPHAVLMMIPEAWENHASMDPKRRAFYEFHASLMEPWDGPACVTFTDGTVVGAVLDRNGLRPARWWRTADDRVVLASETGVLDVPADQIVAKGRLQPGRMFLVDTAQGRLVEDDEIKAGLADDLPYEEWLHAGLLDLRDLADREHVVQSHESVVRRQLTFGYTEEELRILLAPMALSGQEPLGSMGTDTPVAALSQRSRLLYDYFVQSFAQVTNPPLDAIREEIVTSVSRVMGPEHNLLDPTPASCRHIKLQYPVIDNDELAKLIHVNDDGDLPGFACTVLSGLYEVDGGGDALASAIERVRREASEAIAGGARTLVLSDRDSDHRLAPIPSLLLVSAVHHHLVRTKERLRVALVVETGDAREVHHIAALLGYGAAAVNPYLAFETIEDLINQGAITGTESRKAVRNYVTALVKGTLKIMSKMGVSTVGAYTAAQVFEAVGLSGDLLDEYFTGTVSKLGGAGLDVLAEEVALRHRRAHPENPTDRVHRRLEVGGEYSYRREGELHLFSPETVFLLQHATKTGREDVYRKYTDEVERLARQGGTLRGLFALDSDREPVPVDEVEPVSSIVKRFNTGAMSYGSISAEAHETLAIAMNLLGGRSNSGEGGEDPDRLHDPRRRSAVKQVASGRFGVTSEYLVNATDIQIKMAQGAKPGEGGQLPGYKVYPWIARTRHSTPGVGLISPPPHHDIYSIEDLAQLIHDLKNANEQARVHVKLVSEVGVGTVAAGVAKAHADVVLISGHDGGTGASPLNSLKHAGTPWEIGLAETQQTLLLNGLRDRITVQVDGALRTGRDVVVAALLGAEEFGFATAPLIVAGCVMMRVCHLDTCPVGVATQNPDLRARYTGQAEHVVNFFEFVAREVRELLAGLGFRSIDEAVGHAEVLRTDEAVDHWKAAGLDLTPVFAVPETTYHTAKRRVRDQDHGLDQALDRTLLQLAEAALEDAHPVRLELPLRNVNRTVGTLLGAEVTRRFGGDGLPDDTIHVTFTGSAGQSLGAFLPRGVTLEMVGDANDFVGKGLSGGRVVVRPHPDAPFAAEQQVIAGNVIGYGATSGEIFLRGRVGERFCVRNSGALVVAEGVGDHAFEYMTGGCAVVLGPTGRNLAAGMSGGIAFVLDLDPASVNRALVELQRPGGEDLRRLREIVERHHRFTGSAVAASLLGDWPRRSASFTKVMPGDYQRVLEAMTLARAEGRDVDQAIMEASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T084</accession>
    <name>A0A7W7T084_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="14265" checksum="6FFE3D5B66B8B012" modified="2021-06-02" version="1">MPLSEHEQRLLDQIERALYAEDPKFASTVRGAKLRKPSRRRRIQGIALFAVGVALLVTGVMLPKLAGIPVVSVVGFLLMFFGVLLTVTTLRRGDQSAEESSGQGSRPSRSSFSQKMEERFRRRFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T124</accession>
    <name>A0A7W7T124_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28162" checksum="F31FEB67F9886434" modified="2021-06-02" version="1">MEPRHRVAGEIERLISGQIQGQVADQVKRRLAAWNDPRAKLDRRYRRSSRVLTFWFIVLALLAAVGTLAVFGVLSVGAGVTAALGFAGTGVLAVRTGTRMRALNTQRQQLAVTAPPVRPPLPARASAARLPMERLVEAEDTLHDLLNQLDSHALTSVPAESVAHSRETGVEAAQAIRAVAQQLQGVERARDTAPPLDRGPLVEGVRRLRVQLDEGVDGYCALVAAAGRVLAESTASDPRRVLGEATDHLAGLASGLREISHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T165</accession>
    <name>A0A7W7T165_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36975" checksum="4250640343A6487F" modified="2021-06-02" version="1">MSADGVRANLLRELFWTRTGLLLLVLVVTSATCMAVSSGMDPGPVRTFLGSLATGTLISAVVGFGQTLITSSAAQRALVTPVVEESRKALRDLAAEYRALDREFFPSHVFEPTTRPDPAFNQLMMQDLERTRLYGFRGFAGRYAACRVMLAQSECELRAVLADPTDNDAISGRARYLLRHEGADGDYDTIVARLREQITVGLVGLYLARSRCARIDVTIVPDPPLDRLELFDDSAWLALYSNTNAGVVRLYPRTLRFTEGSFLYGMERAEFLRISNSKAGRHLVITPSTGREEFLDRFRLVTGTALTDRGFAELQEKFHAFRREFSASAQLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T171</accession>
    <name>A0A7W7T171_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Act minimal PKS acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9669" checksum="4A98248EC574961A" modified="2021-06-02" version="1">MTEFALRDLTRILKSCAGVDDAVDLDGPVADTAFEDLGYDSLALFELVGRVRREYGVELPDEAVAEMATPRAAVDYIARHLEPVGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B9</accession>
    <name>A0A7W7T1B9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031473064" evidence="2">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="45" mass="4468" checksum="D9184540E62FDA8B" modified="2021-06-02" version="1">MTDRAACRSRLAHSSAGASPCAARPVHPTAADPAPPDPGGGRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U2</accession>
    <name>A0A7W7T1U2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7051" checksum="1750C6886D7FDFE1" modified="2021-06-02" version="1">MTNTTCPGSTGHGADSDWRVHNKDAVRYCNTCNGIASIQYDKAGQVHALNAQLTAALAAQHARRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U5</accession>
    <name>A0A7W7T1U5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="42858" checksum="57E8437AE381134A" modified="2021-06-02" version="1">MSDVAAKKDSLARNRDYTLLWSGQALAEAGFGATLFVLPLLALALTGSPGVSGLVLSVDAAAQLLVGLPAGALVDRWNRKRIMLACEAAQVVALASLVFVLWTDTASVVHLVAVAAVLGAARALFEPAEDASLPRIVPEHQLATAVAMNTARSSLGQMGGSALGGLLYSLGRALPFLFDLVTHCVAFVALAFLRLPPREKPETAEKTHLVREIGEGLRWVWSRPEIRVTTLCAVVLNLFFSAYYLVVIVLATGRGVPSTETGVMASMLGVGGVVGALIAPRLHRVLGPYRSIAIVFWVATALTPVALLIDDGYLMGVLFAGMTLLVPTANTTIGTHQLLLTPDELRGRLSGVLAVAVGTAGAVGPVLGGLLTELLDPVPAVVVCTVGIALVTAYVTVSPTLRHYPEKGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X4</accession>
    <name>A0A7W7T1X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="7227" checksum="EE21B12C33F9EB91" modified="2021-06-02" version="1">MRDDIRYQVLVNDEGQYSLWPAEHEVPAGWRPDGKTGTKDECAAHVDEVWTDMRPKSLRDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T295</accession>
    <name>A0A7W7T295_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14579" checksum="98DA5F13DD5BA1AD" modified="2021-06-02" version="1">MASRLNPYINFAGQAREALEFYKGVFGGTTTLSTFGEFGDKDAPGADQIMHGQLETPAGYTLMVSDTPPGMPYNPGTTITVSVSGDDADELRGYWERLAQDGQVTVPLAKQMWGDEFGSVVDRFGIAWMVDITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M0</accession>
    <name>A0A7W7T2M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkylation response protein AidB-like acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="44118" checksum="BD42440C7F1D0EA8" modified="2021-06-02" version="1">MTTSAPHTWTTAPATADGWIDRAREVATLLATDAVERDRAGATPHAEVALLKDSGLVVLLGPVEHGGGGQDWTTAYRVIREVAAGDGSVGQLLGYHYLWFWAARLVATPEQIAAVEEQATRDRWFFGGAVNPRDNDLVITEDGDDLVFTGRKSFSTGSKVSDVTVLEGVIEGTDKHVFAIVPSAQDAIVFNDDWDNLGQRLTESGSVEVRGVRVPWAQAAGYVDREFTPRVYNTLNVPLIQLVFANFYLGIAKGALTTAATYTRDRTRPWPYAVEVKDAAVAEFHVLETYGDLQAKLWAAEALADRAATLIEAINTHPDSVTPRERGEAAVVIAAAKQRAVDVGLEIGSRVFEVTGARATTNSVGLDLYWRNIRTHSLHDPIAHKRAEVGRYALLGEVPEPTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T8</accession>
    <name>A0A7W7T2T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046274">
        <property type="entry name" value="DUF6307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19826">
        <property type="entry name" value="DUF6307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5829" checksum="EEAF4D302CC4F823" modified="2021-06-02" version="1">MKTPIHLSAYERRVALVQETLSANSELTRKNARVLAVRVLDALDRIPEKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T322</accession>
    <name>A0A7W7T322_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7002" checksum="2A1E08206571F8AC" modified="2021-06-02" version="1">MSKTEDLTGNDLETLRRSAKAALLRNITKQAPITNTAAGVHLLAEAYAWVVSPEQSHGAKVKVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T324</accession>
    <name>A0A7W7T324_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="24504" checksum="57740B2E470D189C" modified="2021-06-02" version="1">MTTNHDPRLLGAYVLGVLDEREARAVEHHLSDCAHCRSELDDLRAAEAALGDLPPEALLDGPPEDGDLLLRRTLRQVRKERVGRVRARGLGAAAAAVVVAVVVLGGGFAVGRGTAPTPDASSSTTVAPPDNAERKLATGVDPATGARMTVEIRRAVGWVRVNASVSGVAQGRECRLVVVGKDGTTREAGSWLVSKLGEREGTNLDGSALVEFSDVTAVEVRDFTGERIVSVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T336</accession>
    <name>A0A7W7T336_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="30826" checksum="E23A9C0BCBEE0436" modified="2021-06-02" version="1">MFELFTDRSRQVIARAQDQARALDHPAIGTEHLLLALVAEDGGPAARALTSIGLTHRDLVHRLGGTGPRPDGGPVASHIPFTPRMKRVLELSLRESKRLADRYIGTEHLLLGLIREGEGRAVGLIGDSGVDLGALAELVVRSSTSEEPDAAATRVHVVRHAGLDDHVAGRIADRLDLRDRPTAVVADLDAAEAVIVVVGKDWTTAADADGRTRLARVDDPVHVAIDTALRRGLRTVVALVDDQRAPAADDLPEPLRGLVSAPVVELRYETFHDNLDALIDVLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L2</accession>
    <name>A0A7W7T3L2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">F4559_003298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="26753" checksum="44A6C6A08DF85BC6" modified="2021-06-02" version="1">MIELKSSGELDAMRAAGLVVADMLAAVRAHAAVGVSLLELDDVAHEVLRAAGAGSSFLDYHPAFAPTPYPGVICASVNDAVVHGIPGGYRLKEGDLLGVDCGAHVDGWHGDSAVSFVVGQARSGDEELIATAERALAAGIAAAVPGARLGDVSHAVGTVIRGAGYGTPRDFGGHGIGREMHEAPGVPNTGKPGRGLTLRAGMTLAIEPMVHAGGRDGYYAAADGWTLLTTDGSRAAHVEHSVAVTDDGPVVLTAPRRPAGPPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3L5</accession>
    <name>A0A7W7T3L5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHA2 family multidrug resistance protein-like MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="505" mass="50425" checksum="769EC0F407C899CA" modified="2021-06-02" version="1">MTTVAPVGAARRWGSAAVLSASLLVVTMDLTILNIALPDLAGDLRPSSEGLLWVVDAYSLVLAGLLVSMSALGDRIGRRRLLLAGYALFGLASAGALFASTTGEVIAVRALLGVGGAMIMPTTLSLIRAVFTDPRERATALGLWAAVSGIGAGVGPIVGGVLLESFSWRAAFLVNVPLMVVASVAAAAVLPESRVPSPGRWDAAGTVQTLVGMAALMWAVKRFAKEQSPAVPEAVVAVVVGVGLLAWFVVRCLRRPDPLLDVRLFARRPFTAGVVAALGSTFAMAAAFLLLAQWIQVVDGAGPVRTGLRLLPAAVAGTVASLLGTWLAARVGARIVLAGGLAVAGLGMVALVVTPSGPAAGHVTVALSLIGAGVGSLAVASAMIMSGTPDDRAGSAAAIEETAYDLGNVLGVAVLGSVAAILYTNGLRSALPDLDPAVASAAEGSVGAATALAVERGLPDLAAAAGAAFTDALRATGLIGGVVMLAIAVVVHAVTPKGTDITAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P8</accession>
    <name>A0A7W7T3P8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014305">
        <property type="entry name" value="RNA_pol_sigma-G_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02960">
        <property type="entry name" value="SigX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="8">
        <location>
            <begin position="204"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="35073" checksum="93ABB67D27CAA53D" modified="2021-06-02" version="1">MTEVFPPADVDLARAGDPAAFTRLVRPLRNELHAHCYRMLGSTHDADDALQDALLRAWRGIGGYEGRSSLRAWLYAVATRTCLDAVSARGRRALPVDLRPSSEHAVVGDPPVTEVAWLGPYPAEKYEQREAVELAFVAAVQHLPGNQRAALLLFEVLGFAVAEIAGMLGTTTTSVNSALSRARRVLVGKEPPTRPDDHRVRDVVARYSRALEEGDAPALVALLTADVTWSMPPMAHWYRGLDAVMDFATRLPLGSCGSWRHVPTSANGQPAVAGYLWDDDAGTHLPWSIDVLTLRDDRIAEVTSFVGAEHFPHFDLPESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3S7</accession>
    <name>A0A7W7T3S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5928" checksum="4BDB0DE3614F6C51" modified="2021-06-02" version="1">MSEQVDFGEFLAALRDFRRDDTVARPTAHTSSVSTRDWQRVEEALNSTGSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z7</accession>
    <name>A0A7W7T3Z7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine (FGAM) synthase PurS component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="39" mass="4151" checksum="9E4DAA9B0B9181F2" modified="2021-06-02" version="1">MSSGVQEGAQVGDAEGTVVDRTLGIMKADKVDDTQYKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T408</accession>
    <name>A0A7W7T408_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20611" checksum="AAF9940A84073F7D" modified="2021-06-02" version="1">MTAGETSIARFVSRLGRSQAKVEVLDLVRLMGQGRQLELDERKATSVAVYEPMSVPPALRTPEYSAALGVEHRDVEVLRDRLCVFYLHEAALHARVGDDEVMAGQLRALVDSPWPVRLVTFAVGGGACLLRPFEYLEFVDEPPVAYVGEHPDVAGGHREALAELDRLALSELASRLFLLERAGVFAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T429</accession>
    <name>A0A7W7T429_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23174" checksum="64C6B6A4436AC14F" modified="2021-06-02" version="1">MDILLVGGLWLDGSVWDDVAAALRSLGHRPVPVTLPAHAGATLDDQVAAVLAAVDAASGEPVVVGHSAAATLAWLAADARPPAVSRVVLVGGFPAADGRPYADFFPLRDGAMPFPGWAAFEGPDSADLDEATRRSIEDAAIPVPEGVATGVVRLTDERRYDVPVVVVCPEFGPEQARKWVEAGEVPELAKAGRVEFVDIDSGHWPMYTKPVELARLIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q1</accession>
    <name>A0A7W7T4Q1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35326" checksum="81D7687A47550E66" modified="2021-06-02" version="1">MARRLPQRTSTTASDGPPRRPETFPARRQPDRVLPPAPQGPRPPCPRARQAPRPVGRRLPPEPAQGPRCAPGMHRGVRPAVRADGRLAHRTTGRDRSASVAHEGSGGTGPRRSHSPALRRVLPGQGRIRRPRRTGTAPRTGGPSRGSPYRIRPRDGVGSTRRRPGPPGDRPRRGHRHQSPCPGLRTRERPPAALHRAHRHRGPRPVSRRERGPHRLQPPARPTSAVEQGVYDSGGSMLRDFLDGLAVHLEPGGEGWLILSDLAERLGLRTRSELLAGVKAAGLHVVDRTDTRPRHPRARDTADPLHSARVAEVTSLWRLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T504</accession>
    <name>A0A7W7T504_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative flippase GtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="27"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="19676" checksum="9705534F286C9C75" modified="2021-06-02" version="1">MSVVRRVLSVFPGPVQALALKHREVLKFLFVGGASFLVTSALNYTLKFTVLKAKPVTALVVATIVATIVSYILNREWSFSTRGGRERHHEAALFFLISGVGVALNSVPYALSRYVLQLQVPHVGLLAQEIADFVSGMVVGTLIASIFRFWAFRRWVFPVEGARVPRKEYGQEGVDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T575</accession>
    <name>A0A7W7T575_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="680" mass="72915" checksum="73CB4C48A7BF7E72" modified="2021-06-02" version="1">MPLLPAVVPTATGKRSDRVPARLARNVAPLFGIASPTNPFAPTTWLCDFNLITISEIARGAPLPTRVQARRLREAPPGDADWVLDERAVFGAALPNEIVSATTNRYGPDTKSAMLLTATNVLLDPVASAIEQVVPLLRAADGGELPLRLRIVAWATLAVEAFRSQPALLIAAFKARAIQRQSLDSPVLAFSSAVRSRPPARCEIGADTATADDRVTHPRDLHVFDRTVDCLRLPETAPAPEDATVDPEPDHERSGAIDLGDEMVDHLVKLLLDASHPAGVGYVWAGEDEPGQAVAEAMLPSAGIVSDLLDHWFSLHVDGRDRENRPVPVALPDPDGLAPLAGTALVLAALGVARSLRKDVGVPGFTARDFLDLVEGIGALADRCLGDDDPLRAVVDGRLAVLRIVVLKTDRTNPVDGHCATAIAAAGRAVELGRAGLLDRGVVADLLGAVCVELNSLRTINATDPASGLPAPAELAELTRRFWHAYGDALDVDVTALDAEHDQSVAFHLHNYASFLGSLPERGDQRRAAALYRDHVVPARKRLYRRLGHFGPLGASYYVATATTCRLAAWERAHGSHAEAVRWAELGYQWITRVLEHSHYAGMVDRSDESAAQFALRAAPALLFAVELGVTPAAKEVDRVRRLLDVLDRWSDRVTGGVAANSSRYAEIASIRSRIDAISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T585</accession>
    <name>A0A7W7T585_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11568" checksum="0BBADFC5073F1DAA" modified="2021-06-02" version="1">MINSPFTRWEGDDVHGRRPVLTAVWVNLDILFPRPADAPRHVIVTGLDLTGVVPGRLHGRFPSVEGDWYGIVNYEVGYADGRRDKLHLVDQFVPFTALCERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T693</accession>
    <name>A0A7W7T693_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="405"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="736" mass="82516" checksum="95BF7B8C36C20EC6" modified="2021-06-02" version="1">MLPYESAGHLEDLRSRLRESHVVVRDRNDVVCVPLAEGVEQVGERRVIASAVRDVLLQTRLLEECLRRILTLEWKYLLRLERPVRFVSRLGGKDLVERALGRGIDGLHVYPEYSLDVRRSGPREYPGVVIGRKTRYEIDLPVEVLLRRGVPMVGVYVLAESESARAWPSQDSHARRKLVGRVADVVDGKLLVQSREGEVKLDAARTWIESSLANFQTVLRKACGRSFERDLAALDDTIAAFNNAERRIADTDRIATALLERGPLDVAAGMTAYLARPLRLKGNQHPHVRTLSEPTFVFDQSGDKTDRYPEAGLNRFGPFDTESFTPKAPTIAVVVPRRFQGRVETFLTRFRDGVRGSSAFPEGFVRKFRLTDCTFTLTAFDGDVQDASAYKRACLNALDTKEKIDLAFVFTSAAQEHLTGNESPYLVSKSTFMSQSIAVQEFQVENITDSPGIAYPLSTMALAVYAKLGGTPFAIKDNGRPTRRELIFGIGSAQVFEDRLGKGERVVGITTVFNADGTYLVSNATREAPYEQYPKALQDALRACLNEIKGRQGWKSNDFIRLVFHVFKLLKDEEAQAIKELVEGLTADFAGVEFAFVTVVDDHPWMILDENARGISAGKGSKGKYVARRGFAVSISRSEMLVTVKGPREMKSELQGAPKPLQLKLHRESTFTDIDYLAGQLFRLTAMSWRRPYPSTKPVTILYSDLIAGLLGKLRHVTNWNSDVIFGKLRYSRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B0</accession>
    <name>A0A7W7T6B0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclohexanecarboxylate-CoA ligase</fullName>
            <ecNumber evidence="3">6.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="535" mass="57957" checksum="E3FA443A918BD9DD" modified="2021-06-02" version="1">MNDYRLRGWWRDGTILDDLRRATAATPDKTAVVCYQEDADGGHGPVALTYRELTAKVERIAGNLHRLGVRHGDVVTLQLPNTWQLVATILACARIGAVAGPVVPIMRRREVEFATRLTASPVYVGAATFRGFDYAAMSARVAETVPTLRHRVLLGGGADGSLDFEAELLAPESSLDGSVEAGPDDVAQVMFTSGTTGEPKGVVHSHNTLYSMNRAQADVLHLSGDEVTAMGSPTTHQAGYTWNLVMPLLLGATSVHVDHWDAALMQEILEKRRVTFFMGAPTFLSDLIARQADAPRDLSALHTFATGSAPIPPLLVERCRDVLGCRLYALWGMTENGCVTITRPEDPAMRAAESDGTAVPGMEVRVVDRDTGTPATGGRPGLLQVRGSAQCLGYYRRPQVYAACVTPDGWFDTGDLARDDGHGGIRITGRVKDLIMRGAENIPAIEVEAALLRHEAVRDVAVVGYPDDRLGERACAVLVTGGVPLTLADVRHHLDGLGMVKHYWPERLEFLPELPRTPSGKIQKFVLRERLRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L7</accession>
    <name>A0A7W7T6L7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050155">
        <property type="term" value="F:ornithine(lysine) transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="PTHR11986:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="405" mass="42570" checksum="D4F3A86833643531" modified="2021-06-02" version="1">MTAIAAPTTGQFIALDDEWSTHNYHPLPVVIAHGEGAWVTDVEGRRYLDFLSGYSSLNFGHRHPALVAAAVEQLGRVTLTSRAFHHDQFGLFCRELAELTGTEMVLTMNSGAEAVESAIKVARKWAYRVKGVPEGAARIVVAGSNFHGRTTTIVSFSTDESARADFGPFTPGFTVVEYGSLDALRAAITPDTAAVLLEPIQGEAGVVVPPPGYLSAVRQLCDEHDVLLIADEIQSGLGRTGDLFALDHEGVRADLYTLGKALGGGILPVSAVVGSRAVLGVLRPGEHGSTFGGNPLACAVGRAVVRLLATGEFQQRSRELGAHLHARLGELVGHGVAEVRGRGLWAGVVIAPGGPGGRAASEALAAKGVLCKETQESTLRVAPPLVISRADLDHGLDAIEAVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P6</accession>
    <name>A0A7W7T6P6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="8204" checksum="D9C8C4C12E07038B" modified="2021-06-02" version="1">MLPQALAQGLDLPEHDFWLFDDERLAILRFTPTGLDGAEIVTDPATVARYRHHRDRAWRHSVAFERYVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P7</accession>
    <name>A0A7W7T6P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="6324" checksum="7FB269BCBEC37968" modified="2021-06-02" version="1">MSSQQWSWEVSVPWRWHGRRGRHARDRPGQSQWTPVVLAAILLATLILLLLTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6S7</accession>
    <name>A0A7W7T6S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="166" mass="19063" checksum="9E7FFDA29A9C9ACF" modified="2021-06-02" version="1">MTERQETRPLTTEDLVRDEHDRVETHDVPGDGRHDHETAYDRTPYDHEPLDEADGGDVADTHHIDVDEPAPDRSVDADAPLFTDTDADSYREQWRSLQADFVDNPREAVQRADELVAGVIQSLATTFADHKRSLEGQWQRGDQVETEELRLALHKYRSFFDRLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T775</accession>
    <name>A0A7W7T775_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="PTHR32419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="161"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="35466" checksum="8B51BABC0115F3B7" modified="2021-06-02" version="1">MTAASPVDFETHGPYAPKPKPGATARPGPAFPHRIAADRVEPGRYHLYAATPCPFCQRSLIVRALKGLEDAVTVTMLDPMRDGRGWAFREGPGHGLDEVNGFALLSDAYKATDPEFDGHWSAPVLWDRHEGRIATNDFRTLDVDLATAFDGVAKNEIDLYPENLRADIDELNDFLYERVHNGPYRCGFAPTQEAHEKEVRALFEALAVVEERLGAHRYLFGDRITLSDIRLWVTLARFDSVYVTHFKANLRRLVDHPNLWRYARDLYRRPEFRSTTDFGQTKRHYFLTHPWINPSGLVPVGPEVDWDEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T785</accession>
    <name>A0A7W7T785_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="2">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6010" checksum="259BC159E917B863" modified="2021-06-02" version="1">MATWRKSSYSGSGGTGGGNCVEVAHDGRRLRVRDSKNPEAGTLTVSRAWLESLKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7D9</accession>
    <name>A0A7W7T7D9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM-linked protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="2">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28654" checksum="DDAED10CCA5E9AF6" modified="2021-06-02" version="1">MPEYPEGAALNRQHQPNPSAAPVQRLRVRYAKRGRLRFTSHRDIARTFERALRRAGVPMAYSQGFNPHPKVSWANAAPTGVASEAEYVEVQVVEEVEPEALRAALDAALPPGLDILEIVQSGGGNLPERIDASRWRIELPGVSPDRLEFAVAALLSATSVEVERLTKDGKRLLDVRPALVSAQVDGHSSDAGHDAPGLSQPCGILMTVVRQTTPTVRPDDVLSALRVVADLVPPVPAKATRMAQGRLEDDGNLVDPLSPDRVTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N5</accession>
    <name>A0A7W7T7N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="44034" checksum="DC8E9C8B6D7A542F" modified="2021-06-02" version="1">MTKNRQNWAWAVAAVAFVALIGAAGFRATPGALIDPLRAEFGWSTGTIGLAVSVNLLLFGLTAPFAAALMERFGVRRVVSVALTLVSVGSGLTVFMTASWQLVLLWGVLVGLGTGSMALAFVATITGRWFVRHRGLVTGVLTAGGATGQLVFLPVMTSLAEDSGWRSAALLVSASALAVVPLVLLFLREHPADLGVPPYGGDEVVPRPVSTGAARRAVTALTSAARTGPFWYLAAGFAICGVTTNGLVGTHFIPAAHDHGMPTTTAAGLLALVGVFDIVGTVLSGWLTDRVDSRVLLAVYYALRGVSLLLLPQLFHDSVHPSMLVFIVFYGLDWVATVPPTVALCRQVFGLSAPVVFGWVFAAHQLGAAFAATAAGLTRDHFGAYTPAWYVAGVLSIVAAFLSMRVVRRSAQAPVVGDLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N7</accession>
    <name>A0A7W7T7N7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ORF">F4559_005200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013173">
        <property type="entry name" value="DNA_primase_DnaG_DnaB-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08278">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00766">
        <property type="entry name" value="DnaG_DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4967841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="626" mass="68809" checksum="DAAE262F67EE3F1F" modified="2021-06-02" version="1">MAGRIRESDIAVVRDRSRIDEVVGDHVSLRRAGGGALKGLCPFHDEKSPSFNVRPTHGTYHCFGCGEGGDVIAFVMKIEHLGFVEAVERLADRAGIQLTYEGGGATIQRDRGTRSRLIEAHRFAAEFYAEQLSTPDAMAAREFLAQRGFDQAAARQFGCGFAPAGWDKLTKHLLHQGFELTELIKAQLTKEGRQGPIDRFHRRLLWPIRDLGGDVVGFGARRIFDDDQIQAKYLNTSESPIYKKSHVLFGLDLAKREIAKRRQAVVVEGYTDVMAMHLAGVPTAVASCGTAFGADHMNVLRRLLIDDDLNGEVIFTFDGDAAGQKAALKAFEGEQQFSAQTYIAVAPDGMDPCELRQEKGDNAVRDLVARRTPLFEFAIKAQLRGYNLDSVDGRVEALKKMVPFVAQIKDRAKRDGYATQLAWWVGWEDEATVVRRVRETATGKVSPSRPRRVDPDQGTLVEVGARPNPADPALWHQREALKAALQVPEMAGPQYDVLPDDAFTHPAYLALHQAIRTAGGASSGLSGPALVDAVSQACAGQTERSVLTELAVEPLRTKADDEYRYVQSVLTRLQQILVGGQIAEIKSRLRRVSPIDEADEYRALFGDLIALEAYHKELGEQAAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P6</accession>
    <name>A0A7W7T7P6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="18586" checksum="E2D6C8ABD0FBAAE3" modified="2021-06-02" version="1">MALADDLVKISGIPAHPLLVHAVVVLLPLACLAAAAIAVRPVWRRRYAWPVLGLTLVGVAAVPVAQETGEQLYEGRFDRLGNPLIDHHASLGNDLLPFALGFGVAVVALLIAGRLADREHAAAEDGGGKDDGGTTTVTRTWRRIAVVIAVVVVASGAAAVVQTVRIGDSGSRAVWEGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W8</accession>
    <name>A0A7W7T7W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="13570" checksum="3059C64E15F11485" modified="2021-06-02" version="1">MITRTSHRDGPSHCGCPPRSPWPGAEVSLLADAGLRGGDAPGPTASAPRSGGEGERALVVGLGAYWFAMTLTVVSRLHRHASLESTHKVETVHPLVWVPLRHIITPRAADIIPNKVVGLSPPPGRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8D4</accession>
    <name>A0A7W7T8D4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="35519" checksum="7A4A8040B4945AF8" modified="2021-06-02" version="1">MTASTSAWVGAAPADPTPVLAARTRGLRKVYGRTVAVDRVDLDVPEGAVLGMLGPNGSGKTTTIRMLLGLVRPTEGEVELLGRRLPDGAAQALPHVGALVEGPGFHPFLSGRENLRRVAAFEPLLATGSIRQAVEDALERVGLGGAAHRRYRGYSLGMKQRLGLAAALLVRRKLIVLDEPTNGLDPAGTREVRKVIADLHADGSTVVVSSHLLSEIEAICTHVAVLHRGTVVAQGGLTELLQADSSALLIETPDVDAALTALRAGRISARPLGEGIRVELIGTTAPVVVRTLVEAGVEVHEARRHRAGLEDLFARLTDAEESEHSLSAVDTIEEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S0</accession>
    <name>A0A7W7T8S0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine/adenosine deaminase-related metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="398" mass="42241" checksum="66D96A2E2040A60F" modified="2021-06-02" version="1">MTGDLLIRSVRPWPGDPAEPVVDVLCRDGLVAATGVGLEVPDGVPAVDGKGGVLLPSFTDAHAHLDSTRLGLPFRPHSAGTGLAELIDNDRRNWRSAEQGVAERATHTLGRTIAGGATHVRSHAQVDVDSGLAKLEGVLAAREAHADRAHVEVVAFPQCGILRERGTAELLDAALRAGADVVGGLDPAGYDRDPVRHLDVVFELAERHQCGVDVHLHDVGSLGAFQVELVCERVAALDMRGRVTISHAFALSTVDSERQRELVDLLAEHDVAVTTVSPGAREPLPLRQLRWAGVRLGLGQDGIRDYWSPYGNGDMLDRAWMLAHRNGFRQDALVEMCVDIATRGGAAVLGRTLGLTEGAPADLVVVPGDTVTAAVMDRAPRTLVVHAGRVVAAEGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z3</accession>
    <name>A0A7W7T8Z3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">F4559_005905</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="139"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4968546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="45423" checksum="002F61FDC517FA8F" modified="2021-06-02" version="1">MAVIEQVGAREILDSRGNPTVEVEVALDDGTLERAAVPSGASTGEHEAVELRDGDAKRYLGKGVERAVTAVLDEIGPELVGLEAVEQRVVDQKLVDLDGTPDKSRLGANAILGVSLAVAKAAAASSGLELFRYVGGPNAHVLPVPMLNILNGGAHADTDVDIQEFMIAPIGADSFREALRWGTEVYHSLKSVLKGKGLGTGLGDEGGFAPSLSSNRDALDLILQAIEKAGYTPGRDIALALDVAATEFHSDGSYTFEKQQRSSADLIRYYAELLDAYPLVSIEDPLSEDDWDGWVQLTAEVGDRVQIVGDDLFVTNAERLEEGISRKAANALLVKVNQIGTLSETLDAVSLATSYGYKSMMSHRSGETEDTTIADLAVAVGAGQIKTGAPARGERTAKYNQLLRIEEALGDAARYAGDLAFPRFTPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T906</accession>
    <name>A0A7W7T906_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12147" checksum="3D87184B2C14D45B" modified="2021-06-02" version="1">MAHSVVVSADGLLLAGSQGLPRDRAEQLSAVASGLVSLTAGAARCFEAGSVNQTVVEMERGYLFLMSISDGSCLAVLAAPNCDIGLVAYEMTLLVERVGQQLTPELRAQLQGVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T977</accession>
    <name>A0A7W7T977_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031316782" evidence="3">
        <location>
            <begin position="39"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="739"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="945"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1299" mass="136327" checksum="3EF7B2198D51BAC5" modified="2021-06-02" version="1">MTRRSATWREPARLSRLLCATVSSAALLAGMTALPAHAQPAPTPTAPTTPEQQAKATGKPVELADQGTERTKVFVNPDGTRTLEARPGAVRVRRDDGWEPVDTSLKTRPDGALTPKAVTAPIVFSGGGTAPLVEFGAGERKVSLSWPSALPKPTVDGDSATYAEVFPGVDLVLNARAEGFTQVLVVKNAEAADNPDLREVALKTSTTGVSLKEGDFETPKVVDKAGVEVLSGAKPMMWDSSGADPQRGEASSADGPSIGAKRAALGLDVTGDSLEVTTDEKLLTGEDTVYPVYIDPPFNASRLGGTELWKNFSNDPNWNNWYTGVARVGYEAQTGQTVRSVWTFDIGALQGKIVKTAWFQATQTHAWNCNDSYVNLWRTTEAGPGTNWNNIGWLQWLDSRLDKGGAGCPTVGVDLNAVNGVVGALNEGKQYVSLGISAGDENTVNGWRKFDPNPALNITYNSRPNTPTELSTDGTGCATGANRPYLRNPNPQFTARVSDSDGAENPLLNARFYWGHVNGGDLGSGGIDGIPNGEIARYNFPTGTFTDGGQYAWTVGVGDYIDPSARSTFCEFVLDLSQPAAAPGVSSTDFPADDEFHGIAGTAGQFTFAAGGVSDVAGYRYGYENPPVNYVAASSLGGTASVNLTAKHLGRNVVYVQSVDRAGNVSAGQPAAYAFHTDQQTVSTGRWQLDGDGSDVADVPHPLTASPTGVSWVAGRDGQAAQLNGGVLTTAGPVVATNQSFSVAAWVKLGANADPNGWYNALSQDGNRNSAFVLQYSGSTKGWVFDTPNADADGSGEAWVTSNQPAEKNVWTRLIGVYDAASGEIKLYVNGVYQGSAKRNTPWNAGGSLVVGRGKQTGASTGAFAGAVDDVVVYDRVLVAEDISELSNRPAVMEGHWAFNDPAPTGPASTITLGAKWDVGYGGTGQSLRLAGGTLSTPAPMRTDQSFTVSARVFLRNKGNWFDAVSQDGNRNSGFVLQYSSSSDKWAFDMPDADADGSAETWVNSTATAATETWTHLTGVYDATAGKMRLYVNGVLQGETTKSSSWNAAGSLVVGRGKQNGASLGYFPGTVDDVFVYGSALTAAQITALHQSTPPAGWAWQLDPAGTSAVDSSTRDRTATVFGGAAITGGKLQLADGDDFAATVGSALRTDQSFSVTARVTPSQLDGRRPIVSQSGTRVGGYYLQYSDSRWTFAMGNADQDNPVEDVVKSSNAPTNGQQVNLAAVYDAAAGELRLYVNGVPQGDPTKHVSTWNAAGSVGIGRALFNGSAMTPFLGGVDSVRVYQGVLTPREIKLISTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N3</accession>
    <name>A0A7W7T9N3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">F4559_006370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="21390" checksum="D9A4055970079030" modified="2021-06-02" version="1">MYEGPVQDLIDELGRLPGVGPKSAQRIAFHLLAAESADIGRLQDALQKVKDGVVFCDVCGNVSAEATCRICRDPRRDLTLICVVEEPKDVLAVERTREFKGRYHVLGGALDPLSGVGPDQLRIRQLLTRIGTDVSEIIIATDPNTEGEATATYLVRMLRDFPGLTVTRLASGLPMGGDLEFADELTLGRALSGRRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P2</accession>
    <name>A0A7W7T9P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13389" checksum="A9B47E6F5E98ABC4" modified="2021-06-02" version="1">MKALDDGRMWAWLEESLLEPVIVAPAEAAQALNSWRAIRDRIRRGAASDQQFAIIFTGEHSRRRTVLVFGQTRQGHMTYWRDGELLEPVPLDLNAVDELIDTWEAVACVAAGNPRQTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z4</accession>
    <name>A0A7W7T9Z4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA gyrase subunit A</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_006636</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003586">
        <property type="entry name" value="Hint_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00305">
        <property type="entry name" value="HintC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01443">
        <property type="entry name" value="intein_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01445">
        <property type="entry name" value="intein_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="13">
        <location>
            <begin position="254"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="12">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1154"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4969277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1173" mass="129672" checksum="4D03CFC507495ABA" modified="2021-06-02" version="1">MSETTLPPTGGDRTEPVDIQHEMQNSYIDYAMSVIVGRALPDVRDGLKPVHVRVLYSMFDSGFRPERSYNKCARVVGDVMGNYHPHGDSAIYDALVRLAQPWALRYPLIDGQGNFGSQGNDPAAAMRYCVTPDTRVRLADGSSPRIGDIVPGALPNSDNPIDLKVLDRNGDPVRADMLFHSGEHPTLTLRTRNGFELTGTHNHPVLCLVSVGGVPTLLWKLLEEIHPGDRVVLQRTPQEELAPLSRREHAEALLAGAFVSEGFVSAGRAGFDGGQSDAGKRVPEFVWQSGAAIKRTFLSYLFSAVGSVSSSDSVDIRCSTRSRVLAREVQQLLLEFGVVASLVDGEHGEIELVVASHRDVRLFAERIGRLDHEQDKLSAILSANPVQSPHACSDHVPFVDEFIRVHGTNQLTDREVLDVVEPLVDGRFHYAEVASVTDAGVQPVFSLRVDTDDHAFVTDGFVSHNTECRLTPLAMHMLADIEEDTVDFRDNYDGRIQEPTVLPSRVPNLLINGSSGIAVGMATNIPPHNLREVADGVVWALDNPEASDEETLEAMIERVKGPDFPTYGLILGTAGIEDAYRTGRGSVKMRAVVEVDEDAKGRTILVVTELPYQVNPDNLVENIAALVRDQKLTGIANIADESNRRSGMRIVVTLKRDAVAKVVLNNLYKHTQLQYSFGVNMLSLVDGVPRTLRLEQMIRHYVKHQIEVIVRRTRFRLRKAEERAHIWRGLVKALDQLDEVIALIRRSDTPDTARAGLVELLAIDEIQANAILEMQLRRLAALERQKIIDQLAEIELEIADLKDILDRPERQRAIVREELLAIVEKHGDDRRTKIVPFDGDVSMEDLIAVEDVVVTITRTGYAKRTKTDLYRSQKRGGKGVQGAQLKQDDIVQHFFVCSTHDWILFFTNKGRVYRTKAYELPEANRNARGQHVANLLAFQPEEEIAQVIQIKNYEVAPYLVLATRKGLVKKSRLSDFDSNRAGGLIGINLREDDELVGAVLCAADDDLLLVSKDGQSIRFHADDDVLRPMGRATSGVQGMRFNTDDELLSIGVVQEGLFVLVATDGGYAKRTPIEDYPVQGRGGKGVLTIQHDRRRGRLVGALIVDVEDELYAITSVGGVIRTSAEEIRKAGRQTKGVRLMNLGEGSTLIAVARNADEPTDVTTGDEDQAEPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z8</accession>
    <name>A0A7W7T9Z8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11397" checksum="1D26B5ADE73B20F3" modified="2021-06-02" version="1">MDVIERTVTTPGGPVRGTDSSAPAPATLSIRESTDLDPGWRGSTGRRRTWRIGCGDVVDRERCLTVMVDRGRVVLVGPPGETAVLSADQLVQLRAALREAAEQAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAT9</accession>
    <name>A0A7W7TAT9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="42999" checksum="CD4EFA50A8030E99" modified="2021-06-02" version="1">MADEGVIGIGDRMRAARRLAGLTQAQMARETNYSLSYVQKAERGSEPASPALVTAWARATKVSPDDLTGAPYKEVIQKDGPLDGLTDLQAILAEGRYVRAEEPLSLGELGRELTRINSLYRGDRGRQALALLPRLIRQLHGALEVARSDEARGDLYSLLASAYVTAERIARRFGYMQLSTPSLDRLDMYAERAGDPLFTSQALIKRARVLMYHGAYEVGLDLVERGLDRIEGSGEGSLAVRGYGHLAGAIVAARGRKIEVARAHLEEARVIAGHVRGESDAYGTLFGAGNVGIHAVAVELEAGDPGKAAEAGFALTLPAEIAPPRAGHHWQDTARACLMAGDSARALEALNRARRVAPQQTRLHPMVRETVRGIATMESRRSGNLANFATWLGSNSASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTJ6</accession>
    <name>A0A7W7WTJ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10853" checksum="0D3C945F888B1BE3" modified="2021-06-02" version="1">MTTVEPALHQPKRTLIAGAEVIVVVLLGFAVVWCWQRGVRHLSFPVADHAPLESTRYLGNWIGAAIALSTVAGVLVLDAVRQTVLGVRTRGRRKAEPADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU0</accession>
    <name>A0A7W7WTU0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidyl-tRNA synthetase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="43012" checksum="6A2999A9E7CCBAA0" modified="2021-06-02" version="1">MYRRFGYHRIETPALEDIRRLQGGEGGENEKLIFQVLKRGLDDETAAGTRTRDLVDLGLRFDLTVPLVRFYAHHHAALPTPFRAFQFAPVWRAERPQKGRYRQFHQCDIDLIGDASVLAEVELIEATTEALDAVGITDTTVRLSDRRFLSALAAHVGLEEPAWPGFFIGLDKLDKIGWDGVRAELVDKRGLPAAAVDQSRTIIEGLIGLDADKVADRLADAVPALPEAVVADMATTVECLAELGRTRAVGWEFDPTLVRGMGYYTGQIFEISHPKSSSSVAGGGRYDKLVGRSLGKDIPACGFSLGFERIVDLITEAPARSALAVLFEPDVPISHALERARQSRAEGRETTVVRRSGKLPAQLTRLEGQGFTGVVHLRDAAAVEAERPLGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU14</accession>
    <name>A0A7W7WU14_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26349" checksum="79DBE04B3B5C5494" modified="2021-06-02" version="1">MNSKPLPQWEPIGGIGSGVFEAPDPEGSMWRLWAVDDPDPGAPFPRGYRLARCDDLDDSDFISGEHGLYYVLDTAGMRITGQRGPDPRGGQMTDTRPHAPGDIVAELSALLVDPEVVDLAALAAVVGDDPDRARYALGVEYGAEFHPRTAVVDLLRAVIDRAGQCWAAWSDTHRCTANADGVHRCTDADLRSSVHDHWCPCYHLRISEAEVPWELAGLVGRTYAPRRPYRDGFAPDPAHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU43</accession>
    <name>A0A7W7WU43_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 10">Uracil-DNA glycosylase</fullName>
            <shortName evidence="8">UDG</shortName>
            <ecNumber evidence="4 8 10">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ung</name>
        <name evidence="12" type="ORF">F4559_001249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8 10">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 8 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="52"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4963890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="224" mass="24448" checksum="4A71AF5ECC78DADF" modified="2021-06-02" version="1">MARPLEEIMEAGWAEALAPVADQIARMGEFLREEVAAGHTYLPAGENVLRAFQQPFHEVRALIVGQDPYPTPGHAVGLSFSVSPETKPIPKSLNNIYREYQEDLGHPKPANGDLTPWTEQGVLLLNRALTVRPGKSNAHQGKGWEPITEQAIKALAARDVPLVAILWGRNARNLKPLLAPYPCVESAHPSPMSADGGFFGSRPFSRANALLVEQGAEPIDWKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA2</accession>
    <name>A0A7W7WUA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7418" checksum="75A2A5CC08E6F024" modified="2021-06-02" version="1">MSTHIGFSTSSFARIEGEAPISCHVVGDEAHLTIGGGALDLVITKTALVDLTGHLVRARDELTADEQLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC6</accession>
    <name>A0A7W7WUC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease ATP-binding subunit ClpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="159"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25509" checksum="47DAC11E3E959FCB" modified="2021-06-02" version="1">MVMTPVQLTDLIVAVAQEHVDPLTRLTSAVELSGQLDELGDHLIGHFVDEARRSGASWTDIGASIGVTKQAAQKRFVPRESVEPARTPRYTDRAHRVVVLARHHARFSERIGTGHVLLGLLDESGGQAAKTIAHLEASDGTTRMVVLAELRDTGPRPDPQPFSAHCTKALELGVRASLRLGQPFVGTEHLLLGLLAETEGTAAKALAATGVTLEDAESHIVAEFRRAISGVQPPAPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUI9</accession>
    <name>A0A7W7WUI9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030585343" evidence="1">
        <location>
            <begin position="21"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21365" checksum="17D6EEAC6B377567" modified="2021-06-02" version="1">MGRRMLVPAVLSVVLGTACATTAPSVPKTPQIPTILPPTTVVRTPAMVDRAPPDECELIVPVEVLNQKLGREIGGETRGIVGVPEPTLGRTAKMDCYYGVGERQPLAAAPVVVGLATYADDATAKDRVTDSVDAERREGATVGETDVGKLKAAVVTTSTERLLLGSLGKTTFVVRIKTGFLPDDQSTPFLAAVAQQAMTPVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL8</accession>
    <name>A0A7W7WUL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="20497" checksum="754C24AC4A4FF241" modified="2021-06-02" version="1">MTGRVVLVGVVLLWCGVVLTVVGSFLPLYGVAMAPTPEFEGYRFGLTSWGDFHEPPLPAEAAPGVPRTAEYGYGLLAGAALAGFGAVRARHVSGRAGAVAGAGVLAGTVWAAWQGSLLLYPGDVPEGTGMEKFVGPGVWLLAAACACTAVGAFLVHGLPRRASKPEGPSVIRVDDDHDATPPFGFPAPAVRLPGDEGHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP8</accession>
    <name>A0A7W7WUP8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">F4559_001411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="117"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="26744" checksum="B642E9E7C4DE7B61" modified="2021-06-02" version="1">MTKRSADDPIRVGVIGARGRMGAEVVRAVEAAPDTAVVAAVDADDPLSALTDARAEVVVDFTHPGVVMANVRFCVDNGIHAVVGTSGFDTARLDEVAGWLRSEPGVGVLVAPNFAIGAVLAMRFAEVAAKYYESAEVIELHHPRKLDAPSGTAAHTARLIARARAEAGLGAQPDATTQEDAGARGALVDGVRVHSLRISGLVAHQEVVFGTTGETLTLRHDSLDRTSFMPGVLLAVRSIFDHPGLSVGLDRYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUY0</accession>
    <name>A0A7W7WUY0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein YjbJ (UPF0337 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6839" checksum="1D53E30A26F3CC17" modified="2021-06-02" version="1">MGAEDKIRNMAEELKGRAKEGFGRTTGDRRTEAEGRGERTKASLKQAAEKVKDALRPKNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV33</accession>
    <name>A0A7W7WV33_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="13" type="ORF">F4559_001457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="51"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="132"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="348"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="423"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="423"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="134"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4964098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="510" mass="53454" checksum="7EB1821A46FAE437" modified="2021-06-02" version="1">MPSKLEGKVAIAPPRPSRTTPVPVSDLATMADAHLTAPDRNHVPVCGATLRAQHVVPGDLFAALPGARAHGADFVDQAIACGAVAVLTDPVGAAKITHDVPVLIHPDPRSVLGALAAKVYGEPSTKVDVWGVTGTSGKTTTTYMVESVLRAAGRTTGLIGTVETRVGDHRLDSAMTTPEAPDLQALLAVMVERGTSDAVMEVSSHALRLGRVDGIGFAVGAFTNLSRDHLDFHPDMEDYFRAKAGLFDGRARTEVVCTDSEWGLRLVRPDTVTVSTTRDANWTATDRRTTATGTQTFIVHGPVPAPFAVELGLPGDFNVANALLAIGCLHAKGVTVDAIRTGLRTVRVPGRMQRVDEGQDFTAVVDYSHKPAAVALALDAVRAKTAGRVITVLGCGGDRDTAKRPLMGAEAARRSDLLVVTDDNPRGEDPGAIREAMLHGALEVPRAQRGDVVEIGDRAAAIRHAVSAARAGDVVVVAGKGHETGQEIAGVVHPFSDVDTLAAAIRETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV34</accession>
    <name>A0A7W7WV34_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative glutamate--cysteine ligase 2</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthetase 2</fullName>
            <shortName evidence="2">GCS 2</shortName>
            <shortName evidence="2">Gamma-GCS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:cellular modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01609">
        <property type="entry name" value="Glu_cys_ligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011793">
        <property type="entry name" value="YbdK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02050">
        <property type="entry name" value="gshA_cyan_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="39963" checksum="97A665656613865C" modified="2021-06-02" version="1">MSVGVSELPYPRTEFDAALSVGVEEEFLLVDAATGMLTPVAPAVLAAPETGLDLQAEMTRFQVESATPVCRTMSEVRRQLALARATLSRLARGQDARIVATGTPVLGGVRPPPLTDRPRYHRIRSEFGGLVDGLIICGCHVHVGIPDEETGVHVSNHLRQWLPVLLAISANSPFFDGRDTGYASWRYLAWSPWPSAGAPPWFASAEDYHRGVGVLRRSGAALDEGMVYWDVRLSARHPTVELRVCDVAATVDEAVLLAALVRAIAVMAMSGRPAYRVPDLSLRTALWRAARDGVEGAGVEPLSGRLVAAADLVRGLVEWTLPALRAAGDDDLVVDGVSRLLADGSGAVRQRRAFTRRGELRDVVDLLVAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD2</accession>
    <name>A0A7W7WVD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8733" checksum="5545FEC01577FD62" modified="2021-06-02" version="1">MPGHDDQDVNFPRASQLAPNPDVRIGANAGASHPVGNTAGVGTVVADAAHPRAGSPRNDYRPTALYSEPTSWRLSTRIDPGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT6</accession>
    <name>A0A7W7WVT6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="4">3.2.1.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="76"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="391" mass="40149" checksum="4EC4AE0487A9A383" modified="2021-06-02" version="1">MIRWGTSAWLGSLAVGAILAATVTFAGVEDRADAGRALPAPTLSTPPTSSPRPTTTTTTAPPDPCGAVAAGMSSRARLAQLVMVGVDPRGADDAVDQVRAEQIGGIFIGGDAVGLLSGGALGSVHATASLPLTVAVDDEGGRVQRVDQLDGELPSAREMVARYSPDEVRALAHKRGAALRARGVTMDLAPVVDTSDQPGRTVIGDRSFSPDPRVATAYALAFSDGLRAAGVAPVLKHFPGHGNTTGDSHLGSVRSPALDALRGTDLVPYRSLPEFGDVTVMVGHIDVPGLTDGRPASVSPAAYALLRGEFAFAGPVMTDDLGAMRAVTDLYDLPDAVLHALAAGADVALWSSGGRTGEVLTRLENAVASGELPQARVDEALRRVLHAKQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG5</accession>
    <name>A0A7W7WWG5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="16003" checksum="510BFF9D4D7C3A71" modified="2021-06-02" version="1">MERTDLHWLALQLYRRLGTRELPTVREQGLSLWGYEVLTLLVDAPVRGQLELVDALELDKTKVMRIVDELEAAGHVTREQVSGDRRRRAVTITPGGRRAWRHTRRALAAIEDDLYARLPVEARDATRNGLLRLVEVLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWK7</accession>
    <name>A0A7W7WWK7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="8219" checksum="89205D77D76333B3" modified="2021-06-02" version="1">MVTRAQDDPDTLRVISRYLAITADGTVHNGDYLDEFRKTEQGWRMARRISVPRFPTGPGVPHEDRSHWLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWN4</accession>
    <name>A0A7W7WWN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018750">
        <property type="entry name" value="DUF2306_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10067">
        <property type="entry name" value="DUF2306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22502" checksum="13F6713A5248F3B1" modified="2021-06-02" version="1">MTTFARRQWPVPAGLLLLAAVPVLAGGIRVAELGGGADVTAANARFFADPVPVVLHIVGATVFCVLGAFQFAPSLRGRRWHRLAGRAVLPCGLIAAVSGLYMTLFYPLPPSDGPLLGGFRIVVGTLMVVALVLAFQAIRRGDVPTHRAWMLRAYAVGIGAGTQAVVSAVWYLAVGAPDVTTRAWLLGAAWAINLTVAEWSVRRREKRLPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU1</accession>
    <name>A0A7W7WWU1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17415" checksum="7B31BD72AA28AAC4" modified="2021-06-02" version="1">MATLTVWKFDDTTAADETVATLEGLAAQQLITLHDAATVSWRTDAKKPKTRQLHNLTGKGALGGTLWGVLFGLIFLVPFLGAAIGAATGALAGSLSDVGIDDDFIKEVRKEVTPGTSALFLLSSDAVVEKVQAVLREHGHRPRLIRSNLNAEQEARLRELISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWX7</accession>
    <name>A0A7W7WWX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTMP kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="25421" checksum="189BC67A07FB14EC" modified="2021-06-02" version="1">MTNTAPLFNPARGREITVVGIDGAGKSTLATRLHHALNEAGHETILIGKHSTEVPMDPELSAYVDQLNALVYRRDARVAQACGDHYWLLALAAWYTLQDKLVIQPALAAGTHVILDNAHHKILARYAVNPDVSTSLAEQVFAHLTEPDLVFFLRISARDALARKGEFSSLETGHSGGADEDFIRYQDTVLAKLREHEQRGGWLSMDVTDMDRDAVFKTAAEALADRLQLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY9</accession>
    <name>A0A7W7WWY9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030854511" evidence="1">
        <location>
            <begin position="26"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="19006" checksum="545FBBC14561E2B3" modified="2021-06-02" version="1">MPRFQALATVIVVAIVLASCGPAMPTDTPHPTTTTETIDATTAEHGDTTAGQAALTAYRGMWKAFASAGTTADWTSPELARYAGGTALSTLTTGLRDDRQRGVVYRGEPTLHPEVVAAAPTSVIVEDCGDSTNWTSHDAATGDEVDREERGRRRIDAVVELQGDGQWRVTDFGVQAVGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX14</accession>
    <name>A0A7W7WX14_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040884">
        <property type="entry name" value="SLATT_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041116">
        <property type="entry name" value="SLATT_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18181">
        <property type="entry name" value="SLATT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18184">
        <property type="entry name" value="SLATT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_3" evidence="3">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_1" evidence="2">
        <location>
            <begin position="156"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="284" mass="31415" checksum="0EC1371F112495A5" modified="2021-06-02" version="1">MTEDALPGFFHDAEREAARAQYQTLWWSRIRLGGALLAALGGALTWKVDGFEVWAAVAVAGFCLALVTELLLAFKRPERQWYSARAVAESLKSLSWRFAVAGFPFDGADARALLRERARGIVTRYEGLHLTAENPYVTERMLTLRAAPFAERKSAYLQCRVLDQKDWYSRNARKNEDRVNQWRAVLIAGEMVAIVLAGCRAFGVWDADWSGVLAALVAGGAAWIGLKRHSSLATTYSLAARDLALIHASLVEAGEETWPAAVAEVEETIGREHALWLATRPADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX46</accession>
    <name>A0A7W7WX46_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="26716" checksum="805D168A6CBA199C" modified="2021-06-02" version="1">MWRYTDGRGVELTLPRRPERVAVVDLLATSTLWAAGVRPVAAALGDDPSDECLTAVGLRPDTVTRLDTPDDPTPDPALLRDVDLVVDRTHGRDLMLLGDTALPAVGLTLKAPGQSLEDVFAEAGALASALGCPPVPADAVARFEDAKRLVRTASGDRTVGFAFARRGWLTVVDPRLYPWLVTLGRLGVRLAPPRRVPLGTRPDVDLLLVFDEGVDVPGSHPWTDRWHAFDHAVCAELFTEFAELSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX52</accession>
    <name>A0A7W7WX52_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031369127" evidence="2">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="18923" checksum="2D9B5B72D9B7DD30" modified="2021-06-02" version="1">MTFLRHFGAVCGALSGLLIAVPGAVEAFTSETAPTSLLLGHSAAFAAPLITALYLTQPRTTFTRVAYAVNVIGLALFGAAAYTLNVVIFFLPPDVVAGTTRIALSTAAFTFIAGTILFGVAMLRARTHPRPAVWLYLTALPVFTLAARLPDTVWTSGLHVVVGASLVWLAFSAYRTPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE1</accession>
    <name>A0A7W7WXE1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17143" checksum="A5FC578B7CE510EC" modified="2021-06-02" version="1">MSDRLARGVLWLAAALTALIAGFFYAYACSVMPGLATVDDATFIASMRGINAVVRNVAFAPSFFGALVVTAVAVALHRRRLRVLPWVVAALVLYAAAFALTMGLNVPLNEWLATVDTTDAAGVRAAYEGPWVTWNIVRTVLSVGALACLLVAVAVRGGPPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH8</accession>
    <name>A0A7W7WXH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21498" checksum="53FCC9CC11C9F5B5" modified="2021-06-02" version="1">MTELTLDPATTALVLIEYQNDFAGAGGVLNAAVGPVMESTGMLAKTATLVEAARAAGVTIMHAPIAFAEGYHEITAHPYGVLKGVVDGKAFVKGSWGAAIVDVLAPREGDIVVEGKRGLDTFASTNLDFILRSKGIRTIVLGGFLTNCCVESTMRTGYENGYRVITLTDCAAATSWEEHENAIRFDFPLFSLPLTAADVLAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY10</accession>
    <name>A0A7W7WY10_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="42315" checksum="00F5C9B5F308DD12" modified="2021-06-02" version="1">MRVLVSGASIAGPVVAYWLDHWGFDVTVVERAPAPRRTGGHAVDLFAPALDVVDRMGLRSAVLDHRTGTDRITLHTPGVPPVDAHLAKVFGMLSEDHVEVMRDELSEVLLGASSDRIEYRYGDSIAELGDDVVFDSGTRERFDLVVGADGLHSNVRRLAFGEVPERFVGAYLAVASIPDDPDLAGRSIGYVDAGRVATGYRAGEDARAVFLFRGPRLDYHHRDVERQKALLRKAFAGMPGKVPGWLADLDGTFYFDGITQVELDRWTSGRVALVGDAGYCPGPAVGGSTSLAVVGAYSFAAELARASGDTTRAFPAYEAAIGDYVRASRGMAVKAARRIIPATHRGVRTMRTVLRVLPKLPVSWGKALASLESDGFRPHDAYVPRPAPEPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD6</accession>
    <name>A0A7W7WYD6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ORF">F4559_005265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="614" mass="68186" checksum="DFA13F2E0546A822" modified="2021-06-02" version="1">MTTFADQTFTPPELIRNFCIIAHIDHGKSTLADRMLQLTGVVEARAMRAQYLDRMDIERERGITIKAQNVRLPWQVQGQDHVLHMIDTPGHVDFTYEVSRALEACEGTVLLVDAAQGIEAQTLANLYLAMENDLTIIPVLNKIDLPAADPDKYAKELAHIVGCEPEEVLRVSAKTGLGVEALLDEVVRRVPAPVGEAEAPARAMIFDSVYDTYRGVVTYIRVVDGRITPRERIKMMSTGATHELLEVGIISPEPKPSRGLGVGEVGYLITGVKDVRQSKVGDTVTWEKKGATQPLAGYREPKPMVYSGLYPVDGSDYPELREALEKLQLNDAALTFEPETSAALGFGFRCGFLGLLHLEITRDRLEREFGLDLISTAPNVVYRVVMEDGAEHVVTNPSDWPDGKRAEVYEPVTKCTIIAPSDYIGAIMELCQAKRGQLGGMDYLSEDRVELRYTMPLGEIIFDFFDALKSRTRGYASLDYEEAGEQDAELVKVDILLQGEAVDAFSAIVHKDHAYGYGTKMATKLRELIPRQQFEVPIQAAIGSRVIARETIRAIRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKMVGRVEVPQEAFVAALSTEDSGKDKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYU1</accession>
    <name>A0A7W7WYU1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012783412.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021465">
        <property type="entry name" value="DUF3117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11314">
        <property type="entry name" value="DUF3117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="5565" checksum="83F98B041CE97677" modified="2021-06-02" version="1">MAAMKPRTGDGPLEVTKEGRGIVMRVPLEGGGRLVVEMSADEANALGDALKAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYZ0</accession>
    <name>A0A7W7WYZ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="132"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32212" checksum="59A34B7FB0B8F13F" modified="2021-06-02" version="1">MSTENTDASPLVRIRSLLPGLARAEQRVAKVVLENPATVAHRSITEVAEAAGTSETTVTRFCKAIGVGGYPELRIALAAETARTAARTDRDLGGDIGPADDLRQVVGKVAFADARAVEETAEQLNVDTLQAVVELVAGARRVDVYGFGASAFVAFDLQQKLHRIGRTCFAWNDTHIALTSAAVLTEADVAVGISHTGSTAETVEALRVARERGAATVVLTNFPRSPITEVADHVLTTAARETTFRSGAMASRIAQLTVIDCLFIGVAQKHADSAKAALESTYEAVSGHRLGARPDGRRRRESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ46</accession>
    <name>A0A7W7WZ46_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="2">3.5.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="168"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="37448" checksum="B50BBB4A772C3855" modified="2021-06-02" version="1">MADTLDLAADPVELTIALVDTPSVSGDEKHIADLVERALREQTGLEVVRTGNVVLARTNLGLPSRVVLAGHLDTVPINDNLPSRLADGILHGCGSVDMKGGDAVMLNVAATVTAPRHDLTFVFYDCEEIEASRNGLGRVERELPEWLRGDLAIVCEASQGVIEAGCQGTIRVEVRAVGERAHTARGWMGRNAIHALGDALATLGAYESRIVEIDGCTYREGLQAVKITGGVAGNVVPDEAVLTVNHRFAPDKSGADAEKYLRELFAGYEVTVTDLSPGALPGLSAPAARELVAASGAAPVAKLGWTDVARFAALGLPAVNFGPGDPSLAHTKQEHVPVEQIRHCRDVLARFLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC7</accession>
    <name>A0A7W7WZC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003795</name>
        <name evidence="3" type="ORF">F4559_005070</name>
        <name evidence="4" type="ORF">F4559_006798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="12194" checksum="648C3D564F815A82" modified="2021-06-02" version="1">MAKQGRRSFTFEFKLEVVRRFVDGGASALELAREHDLASPKQVETWARLYRRDGEDALRPKPKGRPAKPAGTTGLSELERLRQENLELSAKVAYLEKLRALKEQGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZF5</accession>
    <name>A0A7W7WZF5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="23325" checksum="8993EADBA653682C" modified="2021-06-02" version="1">MSTDPEKPAGDASAPSAPDAEPAAQAAAEPAGDQAPPAAEPAKPYTYVSGEDEPETPARAGGGGGTLKKVLIAVVALIVVVGAVFAVRQLSGPGRAEAGDCVSVGEVNDDNVAKVDVLGCDDQKAAYKVGKALAGAEASCPEEGLGSYHEVVADASDAADRAKLCLLPNVSAGNCYKANDLGDYVKSECTGMETFRVTKVVEGSTTTETCEDGSGMSFPEPAVTFCLEPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZS9</accession>
    <name>A0A7W7WZS9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="38518" checksum="FD74A43C739EF42E" modified="2021-06-02" version="1">MNILAEADSGAAEVVAAVLGATITGLITWAVTRKTATAQLHRENESLADSLRKKRAALTEKTKALGAATKEADDLRAVAKKYAAVRKALSASSVVRDYHQPVLVLGPRHVGKTSLVTQWHAPWDHTAFGSTQKHRFCTIPVYDFSRPDALPHFADSEVMTTEHLHLKLRVHDFPGELDAQKSAVVTARTETDQLRRETKKDLGIVLICMFDAGEAVSGANSQTTSYYNGELFANLKTMMGSGQIRIERLIIVFNKYDILAAKLPGRTTRELLKLCIDRFAPILEPLSGACNQERICETFTNLDRDKPLDNQGGSIVLGEAARGLVEKMAGRDEAERVIGEDLTTTFISPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X001</accession>
    <name>A0A7W7X001_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="8">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="8">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pckG</name>
        <name evidence="11" type="ORF">F4559_006750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="10">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="9">
        <location>
            <begin position="243"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="384"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="270"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="512"/>
            <end position="515"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4969391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="603" mass="66845" checksum="D861C1D56D7B2A66" modified="2021-06-02" version="1">MTAVTIPGLDQAPTNHATLLAWVREVAELTCPDEVVWADGSQDEWDRLTAKLVEAGTFVPLKKKPNSFWAASDPTDVARVEERTYICSVDEADAGPTNNWMAPAEMKATLTELYRGSMRGRTMYVIPFCMGPLDAEKPMLGVEITDSEYVVVSMHIMTRMGTKALNRFGTDADFVKALHSIGAPLEPGQADVPWPCNDTKYITHFPEERTIWSFGSGYGGNALLGKKCYSLRIASVMARDEGWLAEHMLILKLTSPEAKVYYIAAAFPSACGKTNLAMLEPTIPGWKVETLGDDIAWMRFGKDGRLYAVNPENGFFGVAPGTDYHTNPNAMRTIEKGNSLFTNVALTDDGDVWWEGMGEPPAHLTSWKKQDWTPDSTELSSHPNSRYCTPIAQCDIKAPEWEDPNGVPISAIFFGGRRATTVPLITESRDWQHGVFMGATLSSETTAAAVGQVGVVRRDPMAMLPFIGYNAGDYFQHWIDTGKSADADKLPKIFYVNWFRRGDDKRFLWPGFGENSRVLKWAIERIEGKAAAQETPIGHVPTADELDLSELDASRADIEAALDFDADEWRAEIPLIEEWFAKIGEKVPTSLRDELAALKQRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X055</accession>
    <name>A0A7W7X055_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13440" checksum="FF10BFFC507DE68F" modified="2021-06-02" version="1">MPAVDPQEMRDAVALVLPWLTGEAEKPDRKVLAAAVRLSLRTLEQSAPGRSVEVRVPPFAAVQCVPGPRHTRGTPPNVIETDPRTWLELATGRLDWAAALDDFRVTASGSRADLSTYLPVVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXG2</accession>
    <name>A0A7W7SXG2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">F4559_000129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="5"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="223"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="31955" checksum="334D28C42F7CDD6E" modified="2021-06-02" version="1">MNRTLRIGTRGSALALAQTGHVADALRAAGAEIEIVTVSTPGDRSSAPIAEIGIGVFTSALRDALADGEVDIAVHSYKDLPTAPDPRLSLAAVPPREDPRDALVARDGLTLGELPAGAKVGTGSPRRAAQLEALGLGLDVVPLRGNVDSRIRRVADGELDAVVLARAGIFRLGRTAEITETLEPIQMLPAPAQGALAVECRVDDVDTEHLLQSTLDDSASRAAVAAERAMLAALEAGCSAPVGALADVVEDLDDNGAVVLRLSLRGVVAAADGDLFRASATGDLTAAEELGRALAAELLDLSGSAAVRPAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXH3</accession>
    <name>A0A7W7SXH3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper chaperone CopZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000428">
        <property type="entry name" value="Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00944">
        <property type="entry name" value="CUEXPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7107" checksum="711B0304735236EB" modified="2021-06-02" version="1">MSVTTTYTVNGMTCGHCAASVTEELTGVEGVTAVDVKVDTGAVTVTSERELSRDEVHAAVTEAGYELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXQ3</accession>
    <name>A0A7W7SXQ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26288" checksum="E7241BBC1194D6C0" modified="2021-06-02" version="1">MTQTQEPVIFDQGTVDRANALVARYPVPRSALLPMLHLVQSVEGYVSQAGIAFCAERLDLTTAEVSAVATFYTMYKRRPCGEHLVSVCTNTLCAALGGDAIYAKLREHLGSEGRPLGHEETSGEPGTPGSITLEHAECLAACDLGPVLQVNYEFYDNQTPEKALELVQRLQTGEKPAPTRGAALTDFRQAELQLAGFFEGRDAADLDGPSAAPETVRGAKIAADRGFTAPAMPDNAEFPPLPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY64</accession>
    <name>A0A7W7SY64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidine phosphorylase</fullName>
            <ecNumber evidence="6">2.4.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.4" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="43761" checksum="24F36EF80D01A055" modified="2021-06-02" version="1">MTHTAVDVIRAKRDRHELDDDQIDWVVDAYTRGVVADEQMSALAMAVFLNGMTARETARWTQAMIKSGTTLRLDVGRPTVDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKLESVPGWRAALSEAEIEAQLRSVGAVVCAATSGLAPADKKLYALRDVTGTVESIPLIAASIMSKKIAEGADALVLDVKVGSGAFMKTEADARALAAALVGIGVDHGVRTTALLTDMSVPLGRAVGNAVEVAESVEVLRGGGPADVVELTVALAREMLASAGIDRDPAAVLASGEAYEVWARMIRAQGGDPDAPLPVGTHTHVVEASEDGYLTTLDAYAVGVGAWRLGAGRARKEDPVQFGAGILCHAKPGDRVVKGQPVLELRTDTPDAIPVVLAGLADAWSVGAGPPAARPLVLDTIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYA1</accession>
    <name>A0A7W7SYA1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20953" checksum="F9065ECA78FF79F5" modified="2021-06-02" version="1">MRFVLASQSPARLAVLKAAGISPDVLVSGVDEDALVASLVDPTPQRIVEVLARAKAEAVDVVEGVVVGCDSMLLTADGRVHGKPKTREVAERRWREQAGTTATLLTGHAVIRKDADGVRTAVAHEATLVRFGTPTEAELQAYLDSGEPLEVAGAFTLDGRGGWFVDGIDGDHTSVIGISLPLTRRLLHSVGITLSDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYD7</accession>
    <name>A0A7W7SYD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase-like beta-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="30200" checksum="AAC5950D66F85EDD" modified="2021-06-02" version="1">MTDSRTPLTLIGLGPMGQGMVKLWLAAGHAVTVWNRTRSRADDVLAAGAVWAERADAVAANRLIVLSLTDYRAADAVLDGLDLTGKVVVNLSSDTPDRTREAAEAVAARGGTLLVGGLMVPAPLLGTEAAYAFYSGPEDVFAEYRDTLALLGRTDYLGADPVPAQLHYQAQLDLFLTVLAGMLHAFALVGTAGVSAKDFAPYMRETLDTMSFYLDETVTSVDSGQHPGDLANITMMGATTDHIVAASEDAGLDAGLPKAVQDLYHRAIAAGRGGENWTALVDLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYF3</accession>
    <name>A0A7W7SYF3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_000562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="305"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4963203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="456" mass="49523" checksum="9EDD0AAFC3B29358" modified="2021-06-02" version="1">MPDRLSALDASFLYLEDSTTPMHVGGVAVFRRPRSGFDYDRLVHLIERRLSFVPRYRRKVVHVPGRLARPVWVDDQDFDVTYHVRRSALPKPGTDRQLHDLVARLMSRPLDHARPLWEVYLVEGLARNRTAVITKTHQAMVDGLAAPEIGQVMLDVSPTPREPAESLWMPEPAPSPAQLVVDALAEVVQRPGELVENVRSATLDTVATVRKVGNAVGGLASAVWSAATPAPGSPLNVRISPQRRFAVARTRLDDFRAIRGAHGGSVNDGVLAVLSGALRDWLLSRGEVVGSRTTIRAMAPMSVRGDEVAAYLVDLPVGEPNPVVRLHHVSHAMRAHRESGQSVAAQTLVRFSGFAPPTLHALGARAASSFSKRLFNVVVTNVPGPQVPLYAAGARMIEMFPVVPLAKNQALSIGVTSYDGDVYFGLNADRDAMPDVDVLAAMVEESVEELMGTVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYN5</accession>
    <name>A0A7W7SYN5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="276" mass="30265" checksum="289D2D128C9A8F1D" modified="2021-06-02" version="1">MRLGVNVPNFGPGTNPEVLRAWARTVEGLGFDLLMVSDHVVITDDVKAFYPAPFYEPFTTLSWLAGVTERITLGTTVLVLPLRHPLLVARMAANLDRLSGGRFVLGVGAGWARQEHDALGVPHDRRGRLTDEALVTIKDAWRDHDDYRAGHIPIWVGGDSAPALRRAVAHGDAWHPLRQTPEQFEEALARLKTAAQDAGKPVPALAPRILLNLTDDPPAERRLGEGTVAQVVADLHRLRDLGAGTVVLDPYLGDPRETLEPEAAWHALAAVRKEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYT7</accession>
    <name>A0A7W7SYT7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="10959" checksum="D23038205ADF4BF2" modified="2021-06-02" version="1">MTGLTRIEVDQVVASAEKLGHVGEDMVERAEALTRALQAQGACWGGDESGQAFAKDYVPASGNMEEAMHKIAEALQAIAKNLVDQAESMRTLDGGNAAALDGLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ07</accession>
    <name>A0A7W7SZ07_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="8" type="ORF">F4559_000923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="7">
        <location>
            <begin position="74"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="6">
        <location>
            <begin position="340"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="326"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="50820" checksum="D34A49A195251BD2" modified="2021-06-02" version="1">MRAHPAGPRHADVLVPANTAGTRPSTPDALDDLHPRVWPRNAARGEDGVVRLAGVDVRDLAERHGTPLFVLDEADFRSRCRDHAEAFGDPTRVHYASKAFLSVAVARFVAEEGLSIDVCSGGELAIALRADFPPERIALHGNNKSVAELTRAVEAGVGVVVLDSFHEIARLDQITREHGRVQQVMIRVTVGVEAHTHEFIATAHEDQKFGFSLSSGDAAEAARRVLKAEGLKLIGLHSHIGSQIFDASGFEVAARRVVGLVAQLRDEHGDDVLSDLSTVDLGGGLGIAYTPDDDPPPPAELARQLANIVAKECEHNDLPTPHIAVEPGRAIVGPGTVTLYEVGTIKDVQLDAGAIRRYVSVDGGMSDNIRTALYDAVYDCKLVSRAAGPDANAVLCRVVGKHCESGDVVVRDCWLPDDLAPGDLLAVAATGAYCYSMASGYNRLPRPALVAVADGQDRTLLRRETEEDLFRLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZD7</accession>
    <name>A0A7W7SZD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoadenosine phosphosulfate reductase</fullName>
            <ecNumber evidence="2">1.8.4.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="29371" checksum="DDA979F02C9650D1" modified="2021-06-02" version="1">MLIDSTRITDRDRDHWDALERYDRMLAADPALDRKAESAVAEVRAFLDAGEAYVSVSWGKDSVVVAHLAALAELTVRVVWVRSVLFETPECDAVRDAFLDAHPQVRYEEIAVEMRNPKRGEPGYDTRHADPHADHQDVLRETLTGRWISGLRGEESRMRRMSIAHRGLSTKNTCRPIGRWDATHVFAYLWREKLPVHPVYAMTAGGHYDRRWLRVHPLGSAPPARSAVHGRDMDSWEDAYYGDVLAAARQARAHLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZP6</accession>
    <name>A0A7W7SZP6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recG</name>
        <name evidence="9" type="ORF">F4559_001253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="279"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="476"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="720" mass="77489" checksum="F042F391BE072286" modified="2021-06-02" version="1">MTTFDEKLESVLGKKSADALATGLGLATVGDLLRHYPRRYDERGKLTEIRGLELGEHVTVQARVKSARQRRMKSRSGELLEAVITDGTSDLHLVFFGRGSRTVERELLPNREALFAGKVGMFNGKLQLAHPDYKILDGSADGADFAGAFIPVYPAAQGIQSWIVANCVEQVLSLWDGVDVDPLPDDLRAEHGLVPLEKALRDIHRPDGWAAVTIAQQRLKWDEALAVQLALAQRRSSATARPASACPPVPGRVRDAFDARLPFELTAGQREVGERLAADLSGEQPMNRLLQGEVGSGKTMVALRAMLQVVDAGRQAAMLAPTEVLAAQHARSLRELLGDLAQAGELGGAEHATRVTLLTGSMPAAQRKKALLEIVSGEAGIVVGTHALIQDKVEFADLGFVVVDEQHRFGVEQRAALSGRSGGSTPHVLVMTATPIPRTVAMTVYGDLEVSALRELPGGRSPIKTSVVPVADKPAWLDRAWQRIREEVGKGHQAYVVCPRIGDDEDDEPPKGDSDRRPPLAVLDVAARLAAGPLRGLRVGILHGRMAPEDKDVSMRAFAANDAQVLVATTVVEVGVNVPNATVMAIMDADRFGVSQLHQLRGRVGRGSAPGLCLLVTEMPDGTATMERLRAVESTLDGFELAQLDLELRREGDILGAAQSGKRSGLKMLSLLRDEDVIVQARDVARRVVADDPGLDRHPGLFSLVAGLLDGDRAEYLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T018</accession>
    <name>A0A7W7T018_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005564">
        <property type="entry name" value="Major_capsid_GpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03864">
        <property type="entry name" value="Phage_cap_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="37901" checksum="3F996DB634EE8EE6" modified="2021-06-02" version="1">MAIVFDGPVSPDAVTSFIRLVPATTGFILNELLPDKEFQDIEVDFEELVLTNRVARFRSYDGRVHVSQRDGMRSGKVRLPPVSSSLNMGEYERLLLEFERIGGTRTDALKQAIYNDALRLVREVRNRMELARGDVLTDFKLSMLAGGNEPAGLEADYGAPAGHLVAPSTLWSNTTTATPLSDLVAWCDRWKTDNGGAGAGALWTSNRVLRLAQRNKEIIDAVYGATQGRTRVTVEELNNLLESEGIPTIRTYDASVDVDGVTTPIIPDDRLLIAPANGEELGFTAWGISATALELVRSNEAEMNFAIAPGVVGLVVKEGPPFREFTYVDAVGMPVISNPRALIVADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T096</accession>
    <name>A0A7W7T096_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aromatic-L-amino-acid decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.28" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004058">
        <property type="term" value="F:aromatic-L-amino-acid decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="459" mass="50099" checksum="F54FCAC780078433" modified="2021-06-02" version="1">MQPDEFRRIGHQVVDWIADYRERVDRLPVLSPVEPGWVRSRLPELNERGEGFDGLLADLDATIVPGTTHWQHPSFFAYFPSNASLPSVLGDLLSTGLGAQGMLWATSPAATELEQHLLDELVGAMGLPDRFRGGGVIQDTASSAALVALLAALHRSGTWRQSGVDGTETVYVSTQTHSSLAKAARIAGLGEDAVRAIAVDPVTQGLDVDALVRQLKSDVENGRKPVLVCATIGTTSTGAIDPVDAIADVCAEHDMWLHVDAAWAGPAALCPELRHFFAGVDRADSFCANAHKWLLTAFDLSLFWTAHPATLVDALTILPEYLRNAATESGAVVDYRDWQIPLGRRFRALKLWSVLRWYGLEGLRAHLRRHIDLAEGLEARVEADENWSLVTPRSLALLVIAHRDGDETTRRAMDAVNASGRAYLTHTVVNGRFAIRIALGAEATEERHVTAVWEALRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A9</accession>
    <name>A0A7W7T0A9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">F4559_001573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="421" mass="44653" checksum="35579981A2C30B8B" modified="2021-06-02" version="1">MSEHFNTSLAEFDPEVAQAVAAELGRQRSTLEMIASENFTPVSVLQAQGSVLTNKYAEGYPGRRYYGGCEHVDVVERLAIARVKELFGAGFANVQPHSGAQANAAAMFALLKPGDTILGLSLAHGGHLTHGMKINFSGKLYNVVPYHVGDSDGVVDMAEVEALALEHRPKLIVAGWSAYPRQLDFAGFRRIADAVDAYLMVDMAHFAGLVAAGLHPSPVPHAHVVTTTTHKTLGGPRGGVILSNDADIAKKINSAVFPGQQGGPLEHVIAGKAVAFKHAASPEFADRQRRTLEGARILADRLAREDVAAVGVKVLTGGTDVHLVLVDLVDSELDGQQAEDRLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGADDFAEVADIIANALLPTADLDGLRGRVEVLAAKFPLYSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q3</accession>
    <name>A0A7W7T0Q3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysozyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="52" mass="5231" checksum="3E28E7236572E27E" modified="2021-06-02" version="1">MTKTLVVIGLLALAGFLAGGVYATWKTTRGLAIALAVLVVVALGGAVAWYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Z9</accession>
    <name>A0A7W7T0Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="28228" checksum="90B05BD6FAC1B01C" modified="2021-06-02" version="1">MSRTEIVDGPRPKHVQLRDILRRLAEQELPPGAAIPSERDLARQYGVSRITVRAAVGQLVAEGLLTRAKGRGTFTARRRMDVQLYLESFTDDMRRRGLLPATDVVECVEEVPPTEVSVALGLTPHEPAYRLVRLRRADGVPLAVERGWYNPRLVPDLTAHDLSESLYTLLADTYGVQLDHAGQTVWAEGSDVDTARLLGVRTGSPLLVFRRLTGSQGRPVEDMTSWYRGDLYQVTMQLDRTVPESGPTSAKGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B5</accession>
    <name>A0A7W7T1B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14319" checksum="B22ACF87814E5A9B" modified="2021-06-02" version="1">MKGTKRMLALSVEAHRTGCAVVVATGELDLAGARRVLDRLDRLVTEGRDRIVLDMSGVAFCGAQAMSALVRTRARAQRAGGWLRLAAVPPHVRRVFGKTDLDRLFPHFPDVAAATSGRPALPEQRRNPPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G9</accession>
    <name>A0A7W7T1G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glyoxalase superfamily protein PhnB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14799" checksum="E645EE0F86BD9BC3" modified="2021-06-02" version="1">MDLAIHTTFLAHTDPEASLAFYRDSLGFEVRNDVGQGQMRWITVGPAGQAGTSIVLHPPAVDPGITDTERQTIAEMMAKGTFATIVLSTPDVDAIFEQVQKTGAEVVQEPIDQPYGVRDCAFRDPAGNQVRINQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z5</accession>
    <name>A0A7W7T1Z5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030775344" evidence="5">
        <location>
            <begin position="26"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="7">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="191"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="408" mass="41192" checksum="AA4AC85700DA0407" modified="2021-06-02" version="1">MRYRIAAVTAALAATVVAVPGSAQAAGTVLGVGHPAAIAGSYIVVLKQKRDLTAADSLLGRDAKVTYTYGRALSGFAVRTDLSGARRLARDPRVAYVVQDHQVDLGGRDAEAAPAPAVTAQGLGVQTDPPNWGLDRIDQRSRPLDKKYFHANTASSVRAYVLGTGIRYTHQEFDGAAVPGTDLVGGVTPPGDDCHGLGTHVAGVIGGRTTGVAKDVTLVSVRVANCQGSASYSQVIGGIDWLTEDALASGKKAVAVAVIGGPTNKAFNDAVTASIAAGVHYSVIAGASNTNACNSSPGGVADATTVGAVDINDVKTSFSNYGPCIDVWAPGANITSAWNTSDTAYSTISGSSAAAHAAGVAALWRHRFPGDSAVEVAAALKANATPGVVTGTNTGPADLLLHSGSIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T218</accession>
    <name>A0A7W7T218_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HSNSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:[heparan sulfate]-glucosamine N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031171648" description="HSNSD domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="HSNSD" evidence="2">
        <location>
            <begin position="299"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="701" mass="75623" checksum="515707B69E15B384" modified="2021-06-02" version="1">MRMSEFGRRGRMPVLVVVALALAAFTVASPSGPAGTDVVEPGSGAAAAPFPVARKHQVPVRPARPPAGGAVLGDRVALRQLVLATGPDDFGLTAWKSVLDVIGTPYDVLYAGTEPVTPDRLVRADGTGRYSAVLLSNGALLHDDGTGVYNSALDGAQWEALWDYERRYRVRQVALNTAPGSTPEDYCLRQRDELDVGPMAVPLTITGPGVDLFDDLRTEPGVPLTHSYLYRADLAPDCAAEPILSTPDGVVAVRSRAPDGRERVALTFSTGAETASTTMIGYGLVRWANRGVFLGERRHWFVVDVDDWFNATLRRRADGTAGQYRMTGRDVLAAVEAQRRLRADHPVAAQFTLNLPFNGSKLKPSAEATCDDDAPDTLSSCSKAMVNEFRWINHTATHPQMNRTAYDVNRTEISRNLDFAAAAGLPVPSCVLKTPEYSGLGVYNPTPNSLDPPTDFGLTGSNQDLLDAARDVGIKYLQGNMSFASHRPTCANCGTYHPLRPELLVVPDWPVSVAFEATEPDEQVSQYNAEYGRNGTAADHADHDVTYDEFVEEEARVASGHLLGGSVYAHTLHQGNFREYAPGHSLGFDWITATVAKYAKYYRVPLKSPDWLSLAGYVRDRTAHFAELASGHDAVWDRSTGAITYSPGSGGSLFLTGVELRDADDADQVSGDDGETYGTDTVAKLGLTGSEPAVVMARPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T222</accession>
    <name>A0A7W7T222_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="13115" checksum="07F249DB3FCB2726" modified="2021-06-02" version="1">MTDTDYRDGSVLCRDDALVIRRYYFPTLTAKRVPYDRVVRVLRYPLTARTGRLRLWGTANPTRWFNLDGGRSGRTTAYVVDTGRTVKPVVTPDDPRAFERALAAHGVEITDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2G1</accession>
    <name>A0A7W7T2G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
            <ecNumber evidence="4">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030619004" evidence="2">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="57"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="532" mass="56076" checksum="6111EF69C55C0EA2" modified="2021-06-02" version="1">MRGAAVGLVAACAFTALPARASTDVVPAALLGAVLDRVTVLDLQQGMDARVFTSEQVTRAYLRRIDTLNPRLNAVLGVNPDAVELARQSDARRREHRSRGPLEGIPVLIKGNTDTADRQPTTAGSTALSEAKPAKDAFLVSRLREAGAVILGKANLSIWSNFRGSDALAGWSATGGQTRNPYVLDRSPCGSSSGSAAAAAANLAAITIGTDTDGSIVCPAAMTSTVGVKPSLGLVSRTGVVPITSRHDSPGPITRSVTDAAVTLWALHGTDPADPDSAAAAGALPADYTRVLRTDALRGKRIGVWRKGHQGIDPDADRVFDASVAKLRDLGATVVEGADLPDFQEVVVPHLLPAVLTEFKHDLDAYLAKTPGSHPKNLTGLIEYNRRHADVELATFGQDLFEMADKTDGDITDPEYRSHREAATTAGRQGIDDVLAAHRLDAIVTPTELPAPPVDYQGGDPVRDSFAGTSRHTSAAGYPHLSVPAGFSREGLPLGLSFLGTRFSDAKLLSFAYAYEQATHARKAPRYLPTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U5</accession>
    <name>A0A7W7T2U5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11800" checksum="70EEEAE7EA9E5C6D" modified="2021-06-02" version="1">MRIDTPGGGLDVDVDALIASSRDFSGLSDMLGQLRRHADALREVLRLGTSPQAHDLNRKFADRHAALVERLEIMDTQLVGIQDAVRDSAESYLRHEDDNRARFGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2V5</accession>
    <name>A0A7W7T2V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase A subunit family amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="477" mass="51648" checksum="D0244CA7EE49D4AB" modified="2021-06-02" version="1">MTATRIPDPTPPATARSIPRPAEAMIRYARHADVAYPDHRPEPPPLLEVPLAERLRRVDAGEWDDDEWTAQTEAWTAAADPRYRALVARRRPDPHTPTIRVGVKDTVDVAGFPTGLGLRHYRHHPKASAPALAPVERAGDLVIAKVVSTELNIGIGSGCLNPYFPHIDPAGSSTGSGVAVAANLCDLSMGTDVLGSVRWPAGQCGTVGLRMTHDSRSLGGIFPLSPAMDAVGWVARTADDLALLWRRLGLGALVEPTGAGIGERYRIGVVDNVRDGSCDPEMLGAVDQVCDWLSDDGHLVDPVRLDDLWRSRGDAWQLCARQAWDGYRHCRQWITVPLHESTERALRIGARVDDRHCAAILADLEETRREVPARFGDHCHAWVLPLDPSTPPDLRVRGPMASTIPAPGDPDYDRAIGYTPIASFAGLPAIAVPVRLSTVNGAPLGVQLVGPPGGEERLIDLARRVQRHSGDLGLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Y3</accession>
    <name>A0A7W7T2Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="37959" checksum="C21AE78A0EE90A38" modified="2021-06-02" version="1">MTHANAPLTELGRLRLARCVVDEGWPLRRAAERFQVSPTTAARWASRYRELGEAGLVDRSSRPHRSPRRLPTRRERRIVKVRLARRWGPARIAHLLGLNPSTVHRVLRRFGLARLAHLDRATATPVRRYEHAAPGDLVHVDIKKLGNIPDGGGHKVHGRRAGGRNSSAHRDPTRPRKVHGRPNLGYAYLHNAVDDHSRLAYTEILPDETKDTAAAFWTRAQAFFREAGVTVRRVLTDNGSCYRSRLWRDTLANAGITHKRTRAYRPQTNGKVERFNRTLLDEWAYAQAYRSETERRETLPRWLHTYNHHRGHTALKGQPPASRVPNLTGQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z2</accession>
    <name>A0A7W7T2Z2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">F4559_001754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="31772" checksum="586AF213B01C141B" modified="2021-06-02" version="1">MSGNVVVDREILLVVHTGRRSNVSLAREVAVRFAAAGIALRVLADEAAALDPAFFAAVVKADEQAAEGTELVFVLGGDGTLLRAAELARPAGVPVLGVNLGRVGFLAEADSDALYEAIATVVDRGYRVEERMTLDIVATLDGDVLERTWALNEASVEKSMRERILDVVVEVDGRPVSAFGCDGVLVATPTGSTAYAFSAGGPVVWPDVQALLVVPSNAHALFARPLVVSPASVVALEVDAGGHPAVLCADGRRTVELPPGARVEVVGSPTPLRLIRLRDGVFTDRLVEKFSLPVQGWRGPAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J4</accession>
    <name>A0A7W7T3J4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="38743" checksum="59006F3268422A1A" modified="2021-06-02" version="1">MNSTVLVVGAGIAGLTLAAALHRRGHTPVVVERAPGPRPGGQALDVRGPALDVLDRLGLLAGARAARTRMRGMSMHDAAGTELWRSTEMTYSAGMLDSADIEVPRDDLTTLLHDLVRDDVEIVFGDTPVAIAPDGEVTFAGGTRRTFDLVVGADGLRSAVRRLVFGADEEFVRHLGAQVAVFGADNFLELADWQTWTQDEAGTWCAYPVHGNARLRITVGVPTSADERREPDQWRAHLSERLAHLAGDTPRVLEAMRAAPDFYSAAMAQVVMDRWHDGRVVLLGDAAHCPSPLSGQGTSLALVGAHVLAEEFDRDPAHAPAAYEARMRPFVAVNQALATENPGQGASPESLERAKNAFSLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q4</accession>
    <name>A0A7W7T3Q4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8316" checksum="58E2EFCDF494BEF1" modified="2021-06-02" version="1">MSNPLSHRARALLRAVEAGRAEVTLSREPDLKVDGLLCSDQSSARELSRAGLLRPARDTPGHWVPCELTAEGRALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T2</accession>
    <name>A0A7W7T3T2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15461" checksum="4D2794A780DE33D6" modified="2021-06-02" version="1">MVNVLSVGWSPADPGLADWYVDNSPLARWLSRFGHEVPAPRAHGVFATRHPDDLRALLGRPAPSGRVPLYRCARCGDPDCGVLAVRVTRDENAVQATVTWTDFAWEADGDPERFAAPTITFDLARYEAVFRHLPHRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T7</accession>
    <name>A0A7W7T3T7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_002174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030635931" description="Histidine kinase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="224"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="45402" checksum="0D965C4933FAC90F" modified="2021-06-02" version="1">MRKSLALVSLAVTSMVALAFLIPLATVVAALAEDRALGEADKQAAALVPVLVITSERAAVEQALASAGGHVVVHLPDGTRIGPEAKATDDQLRRAREGRSFRDTVSDGRVILQPVLLRGSTVVVEAFVPEGELSRGVLPAWFALSGVAVSLVLASVLVADRLGARVVKASRELAEGARRMEEGDLSARVAPTGPPELADAGGAFNRMADRIGQLMANEREMLGDLSHRLRTPLTALRLDSELLGTDANANRVRQAVVALEREVNEVIRAARRELTDPDGNRCDAAQVVHDRLVFWSALADDQRRLWNLRGTERPAFVPLTRTDLAAVMDVLLGNIFRHTPEGVGFVVALFHQPDRVVIVIEDAGPGIEDLETALRRGGSSAGSTGLGLDIARRAAESTGGSLVVDRGPLGGTRVQLRLSRLAEPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U3</accession>
    <name>A0A7W7T3U3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="803"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1800"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="838"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1899" mass="202567" checksum="20BDF0A7F2A78E6E" modified="2021-06-02" version="1">MSSESESSRLLIGGALDLDRLRHAVGTLVARDTRSAADPEAAALDIARRALRTAGDALVAVRIADDATVLAGTVPTLRDASRRYLPDDPLPLLDPPADLPRPAVADERKNRVRGVLPAGATDPAVLLAAFGVVLGRHAGPRRFAVAVDDEAAVVDLTGTFRDVVGSVRHDRFPLAAARTRFVVTESPTTLFGHAAVPLDAPPPDSPHDLVLRVRPDRGTADLDHSVRITGERATDFLAQYRLLLEQVLADPDRPVDAYPLHTGTPAAHTRPVDAPGPPVSVGHDGRPPTPATSTRPVDVPGPDTPAEDDNPPTTPVGADPRPARPPVGVPTLLDRIAGHDPGRTAVEWGAFHWTYAEITGQAGAIAGRLAAAGVVEGDVVALHAARLPVLLPAILGILRAGAAFAVLDAAHPVERNAGLARSAGLTTWIDAAPGRAAPFGTEPVLRLVGLHAAETAEPVDVPYDPDRTAYLTFTSGTTGVPRVVAGTGGPLDHFLHHYTREFGLGPDTRGTVLSGLGHDPFLRDLFAPLWAGGTTVFPDFDIRDTERLAEWLRTATLVHITPGLAAAVARVGVEYPRLRVLGFGGEPLRTPVARRWAALAPAARHLNLYGTTETPQAVSIVDVTTSAAGVAPIGPGFGGLAVRVVDTAGRPAAVGELGEVVVHGHRLARYVDGRGTGGFGDGHYRTGDLGRVRPDGSIDLAGRSDDQVKIRGHRLSPTEVEGVLLAVPDVTGAHVAARPDRLVAWITADRALDAEQVRDHLARVLPDYAVPAVVVLDEFPLTPRGKIDRAALPEPAAGGTHVAPTTPAELRVARLWQEVLGVERVGLDDDFFALGGHSLLLGRLRAALGVDLGSLFEHRTVRAQAALAPAHEVRAIARAATDALSATQERLWFEQRLDPASTAYHMAPVVHLRGDLDPDLLERALQAVVDRHPVLRTAFPAGPTPTQVVVADVRVPFTRHDLRTTPDEVDRHLAEVVREPFDLTRAPLLRARLLRIADDEHLLAVVVHHIVFDGWSIGVLLTDLADAYIGRGKPEPLAFADFTAWEKSEVDTGPPLDRWADRLAGAPTVLDLPTDRPRPAVRRARGARHRLTVPAERLHELARTHDVTLFTVLITAYAVVLARWSGRRDLLVAAPVANRARPEFEDVIGPFLNTLVLRVTLDPDAAFGDAVRRVHREIADDLAHQEVPFGRLVTRLDPDRDLSRTPLAQVLFALQNTPLDPPAVPGLTLGLRYTDEATAQADLALRITDTGTALEGRLDYDTDLFDAATAARFADHYATVLALVAEDPGTRVDDLDPITPAERRAVLETWNDTTLPADDATLRDLLTEHAGTALWWRGEEISYADLHTRAGRLATALRAHGVGPDVVVAVHLHRSPELIVALLAVLKAGGAYLPLDPDYPVDRLRYMLADSGARVLIGDFAADVPTVPVDVPDPVLTGDPGTGPDHLAYVIYTSGSTGRPKGVQVAHRSIVNRLRWMRDDHAVTAADRILQKTPTSFDVSVWELFLPLVTGAVLVIAEPGGHRDPAYLSDVISRAGVTITHFVPPLLATFLAAGGTAASLRLVVCSGEALPPETVHRFADAFPGVRLENLYGPTEAAVDVTAYRADPAERTVPIGRPVANTRVYVLDDRYRVLPVGVAGELYLGGVQVARGYGGRPGLTADRFVPDPYGVPGDRLYRTGDLARWRADGVLEYLGRTDDQVKLRGFRIELGEVAAALGALPGVAHAVAVVREDRPGDRRLVGYVTPAAHDPAALRAALARDLPDHLVPAVIVPLDALPLSPSGKVDRAALPAPVRATGGEPPRAGTETVLADLWRQVLDLPGVGRDDDFFAVGGDSLHAVRVVGLARDHGLDLTLQDLFRGRTLAAVAGSLTTTSHPAPTTDRTAAFGLLDPADLARLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T407</accession>
    <name>A0A7W7T407_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28850" checksum="7F37636583E4C57C" modified="2021-06-02" version="1">MSQTVDYTRYAHHPGRGETAMRSNPDAIARDLDTLDVRPGHRVLEIGTGSGYSGALLAALVGERGTVTSLDVDAFLVDWARLIHHEHGVRTVSCVTADGVAGHPPDAPYDRIVAWCTPPRLPAAWTDQLADDGLIVTPLPVAPVPHVTVVARIRVTGGVPTAEAIADGGYMPTTATPGDSDTPPRHVDWEYRRPDRTGWISTAWRDHDDPLHTHARRLLDRLLDHPHTPPTQPDRAPSGFDWSSWRSWIAAHHPDGLTVAARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E3</accession>
    <name>A0A7W7T4E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="484" mass="50201" checksum="66CE17B2C4AF476E" modified="2021-06-02" version="1">MPTDNPTTSTLDPRRWKALALLCTAYFMIIVDSQIVILALPSIESELTFGVNGSQWVMSAYLLSFGGLLLFGGRTADLLGGRKMFMVGTALFLIASVVCGFAWTGGVLIIARVVQGIAAAIMAPTAMAVLMATFPEGKERNRAIGIWTGVGAFGATAALLVGGSITQGLGWEWIFFINIPLAGVVLLVGPKLLRETAIREGKKSYDPFGAITVTGALILLAYGIVEAPVVGWGSGQTLGILAGAVVLFVLFIIAERSAKAPLVPLRVFRLRSLVSGNLMTLLVSMTIYGGALMMSIYAQQVLGYSAVLFGLSTAIYAFMSVVGSNLAGPLTTKFGYKKVAVFGATALALGAYLLSRVTADGNYWADLFPAMVVFGFGIGTTVVASAIAALSNVPADESGLASGINNSVFQIGAAFGIALCTTVSVAYTDTGAAVAKVGLNAGVQAAFLTAFVFAATCLVIALILNLIRDRQPAAQPTTPVVAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T524</accession>
    <name>A0A7W7T524_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11843" checksum="2BA48D596A114882" modified="2021-06-02" version="1">MDYLADCRARLAFDLMSNTWNPVVLWALRTGPHRPSALRRHIGGIRPKVLTETLRRLENHGLVTRTPHPDRVEYTLTALGTTLLPPIAAFGEWAHDHGDEVTIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T537</accession>
    <name>A0A7W7T537_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030930487" evidence="2">
        <location>
            <begin position="32"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="30721" checksum="D39F5C8F7290CB63" modified="2021-06-02" version="1">MEQPALAARISSRARLTSLHSRTTSTSSAPAAATSDSRPRLPPPITPSMSCPPRRTAAMCSSNGSTGRPAASKWPSCPGNRRTSVGRLIKVPDGTPVTVRVLGDEVDFGGTLRVPTAAIVGDLPDPSVVRSPRLDDTGPVIVAPDAWHAAFYPDAIPTPVDDPLTGGLALLDRERPAAGADVRRVVSQVAPVRESYGTVSAFRGLVLCRPGTPEEIARTLCVGAARTRFDTITDLFAIPDAYGDLFVAINELHLTGGNRAEATRSLDVLRHDTTTAHADRLLAGLADALANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T554</accession>
    <name>A0A7W7T554_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="695" mass="76718" checksum="7E360025B0E06D32" modified="2021-06-02" version="1">MNVDNTNSASDQAWVGQQIGANFGTTVFHQGHATYRLSGDDRQERIDVAIKQVKAGMPRLAEEALRRVMRDGPVTARVAFYYALSLLGDRAYTELDSSVDREFRMACESARKAPSDPWTGALAVVEELMDVVSAHPGERPVEAAAVEQVLDRLKSLDGEIRLEIMLNVDRIVSGALQDALYEANARLVVETRMDGGRGQRAWKFFEPDPTEPRLLDWGVDRVPGGWRPVVAVVAALLGLVAMAVASDDWTTWLALPLLAGGGYLAFGAALERGMCNARMKRADREHGVPAAPAPPMSPGHWVSTAFVVEVHRLVEEAFQAERPHVVGDWISATYGVCEELKRRFVHLYGNAQRTPAEFRWLIRWHVRQVAERWRSGDFYAYRQALAVPRTVGLRFGSGVATVAVGLVVLLCGDGAIAAPMLGLAGFLGGTWFVARSVAPKDAAIARDEALRLHRAEHEEFERWRAVLADRPEDVEMGRWLELDAAYFRAVALRRFLLSPKDLVEHVVLTEGAPGADRARVRGGPTRYSAYQVLIFLLTKGGVRELEVRLDFLDGVAHDEQRKSFRYEALASARVEEVGARTAADGEDARAGVPVAFDRHRLHRRRFVLSLLDGHPISMLAEYFRGPSATGVESEFELSRLALGSSGIEGALYVLESVAAEGPAWIGREEDRRRRRQDVWRQGRPSGATPGISAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T559</accession>
    <name>A0A7W7T559_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6680" checksum="1CE63B823C5F889C" modified="2021-06-02" version="1">MLHAGYRERRRLERDLHDGAQQRLVSLGVALRVAQRHLDDGTVDGPLDQSVAESECRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5D7</accession>
    <name>A0A7W7T5D7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase A subunit family amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031348058" evidence="2">
        <location>
            <begin position="28"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="72"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="534" mass="56075" checksum="62F036A245E3E359" modified="2021-06-02" version="1">MARRSRRTAALVVGAVLLVTTAAPVEAAPGGREAADWVVDLDATALGELLAQGRVTSVGLVKAYRARIDAYEEAYADQPGVNAVIREDPQALAVAARLDAERRHGHVRGPLHGIPILLKDNYDTADLPTSNGSLALRHWRTADDAEQVERLRDAGAIVVAKTNLHEFASGVETISSLGGQTRNPYDQTRNPGGSSGGTGAGLAAAFGAVGLGSDTCGSVRSPAAHNSLVGLRPSLGLSSRFGIAPLSYTQDVGGPMAKSVRDVALVLDATVGYDPDDPSTAASIGRTPRTYTTSLRDNALAGARIGVFTDFMGATEPERPTTSLVRAATGDMAGQGATIVDVPPQPALLAAVEASWVINDEHERDLNRYLARPGSRFPHSLARLEPPRDVVTLADIVTSGQVTPTVLVRLKDRLGRSTGPQDAYHERLARRAEAQRLLATLMAEHDLDALVYPTVPQQAALIGQPQPSGRSCALAANTGFPALTVPAGFTPDGMPVGVELLGTPFSEPTLLGLGFDYEQATRHRRPPTSTPPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F2</accession>
    <name>A0A7W7T5F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Magnesium-transporting ATPase (P-type)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="843" mass="87191" checksum="50011E945102FD0F" modified="2021-06-02" version="1">MPATTKSTTGGLTSAEAARRLRENGPNLLPAAGGTHPVVLLLKQFGHFFAILLWVAAALASVAGMPALSVAIALVVVLNGVFAFAQEYRADRAAQRLRDLMPTRATVRRDGEPRVVDAADLVVGDEVLLQGGDRVCADARVFQVAALAVDESMLSGESVPVHPAADDVVRAGTYVTEGEATVVVTATGAHTRLAGIASLTRDAVRPKSPLALRLHRVVTVVGLIAVAVGVAFYGVAMLLGLDPAEGFLFAVGVTVALVPEGLLPTVTLSLARAAQEMAHRKALVRRLDAVETLGATTFVCTDKTGTLTRNEMAAVRVWTPAGEVSVEGEGYAPTGRVTGGPDALAAVRRAAAGAVRCSPGARAEHRDGRWSPVGDPMEVALHVLAARVGADTSTPEATRFPFDPRRRRSSVADGDGVHVIGAPDAVLPLCAPTPGAREAVAELGARGLRVLAVAWRPGAAVDQADAERDLVLLGVVALQDPPRDDVADSIALCREAGIKLAMITGDHPATARAIAVQTGLLGPDGLVVEGGDLPADDHALGELLDRDGVVVARVTPEDKLRIARALQGRGHVVAMTGDGVNDGPALRAADIGVAMGASGTDVAREAADLVLLDDHFGTIVAAVELGRATFANIRRFLTYHLTDNVAELTPFVFWALSGGSYPLALSVLQVLALDIGTDLLPALALGAEKPNPRTMTGPARTGSLIDRSVLVRAFGVLGPAEALAAMAAFTLVLLAGDWDLGDPVLAATASGTAFTAIVLGQLANAFACRSATTPVKTLRGNRLLVGAVLFELVLLAVFLFVPPLPGLLGGSAPTPLGWALAATTIPVVLLVDAVQKWVRRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F7</accession>
    <name>A0A7W7T5F7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretory pathway VirB4 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="249"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="640" mass="68606" checksum="C831E836326BF94B" modified="2021-06-02" version="1">MASRTRKTNGNPAAPTAASSAAAAFTPDALSVAARHLEVGGEWVASFAVVGFPREVHPGWLAPLLTYPGRLDVSVHIEPIDPATAASRLKKQLAKLEAGRRHTAEHGRLFDPQVEAVTEDAYDLSSRVARGEGKLFRVGLYLTIHAASEKTLTDEVAALRSLCASLLLDAKHTTYRSLQGWVSTLPMGLDLIGMRRTFDTSALAAAFPFTSPDLPAPDPTSVAAPSGVLYGYNVGSQGLVHWDRFGEGMHNHNSVILGRSGAGKSYLVKLELLRSLYRGIEIAVVDPEDEYARLAAAVGGTYVHLGARGVRLNPFDLPIHTRADGRRTAPKDALVRRSLFLHTVIAVLVGGELEAAERAALDRAIAATYQSVGITADARTWTRPSPTLRVLRDQLAGAGQASDRAAGELAARLHPFVEGAFKQLFDGPSSVNPEGHLVVFSLRDLPDELKGIGTLLTLDAVWRRVSNPAIRRPRLVVVDEAWLLMKEKSGAEFLFRMAKASRKHWAGLTVATQDTADVLGSDLGKAVVANAATQILLRQASQAIDEITQTFDLSAGERAFLLSADRGQGLLSAGTQRVAFQSIASPTEHYLVTSNPAEIAAYADTAEPVDEADTAFVDLGFDEDEFDSDSGDDQIHLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T630</accession>
    <name>A0A7W7T630_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable inorganic carbon transporter subunit DabA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dabA</name>
        <name evidence="7" type="ORF">F4559_004610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of an energy-coupled inorganic carbon pump.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with DabB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01871">
        <property type="entry name" value="DabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018752">
        <property type="entry name" value="DabA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38344">
        <property type="entry name" value="PTHR38344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10070">
        <property type="entry name" value="MpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="904" mass="98797" checksum="BFB251E9DE8A56D8" modified="2021-06-02" version="1">MNPVAELVDRAATLLPEQGPLQAFVHHNTLHAFEHLPFADAVARAAEVFGTQPYLSEATFHGFLADGRITPADIAAVVAAEVPDDGEPVVPGGPTARRFHELRLGALVEVPRGAALRWLLDETDAVDVTDPRWARLLTAEPPTGAAGTPAVRPRDRVLTETGIDADLLTHPLLIRLTAAFLDQGVAYWPMPDREHGLFAAFRSLYAGPGAVLDPFLRGLPAFLRDRSDWTAEHAVEWALDELDVAWSDREAVVTATLLSLRGWAGMVRQFEHRPDRAPVDPHPARLVDFLAVQLVLDVFALRYVRADVEPEPLAQHHHGTLERAYEAYVLARRMDVDLPDHAHAATWLAVVDRCDDLERRRLLHLAYERRHRVGVLDGLIAHQNVVEPTGKPAFQAVFCLDEREESVRRHLEESCPEVETFGFAGFFGVAMNYQGLDDVRARPLCPVVVTPTHHVTERAVDDVVPGRRLRAGWTNLLSVGSRTLARGGLLSIAMGAAGLASLVGRCLFPRAAHRWEHRSGHGGPKTRLETDFSVPEMADIVGTVARTAGFHRDQSPLVLIIGHGSSSMNNPHESAHDCGATGGGRGGPNARAFAMMANDPRVREVLAERGIPIPDGTWFVGGYHNTCDDTMRYYDEDLVPESHGEPLRQAKDSIAHACVLAAHERCRRFESTPTDLALEDALAHAEEHAVDLGQPRPEYGHATNAVAIVGRRARTRGLYLDRRAFLASYDVAGDNDDALLTALLGAVGPVCAGINLEYYFSFVDPAGYGCGTKLPHNITGLLGVMDGHASDLRTGLPWQMVEIHEPVRLLLVVEAAPDRLNAILNGHAVLNRLVGNGWIQFVSWCPDTNAVHVFQDGSFQPYAPERTEFPVVTRSAQVYAGERDHLGCAHVLTGAEVPVPVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T643</accession>
    <name>A0A7W7T643_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ORF">F4559_004628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21628" checksum="348E0BDD242F1CBD" modified="2021-06-02" version="1">MFVKLCGLRTEADVATAVDAGADAVGFVFSRSPRQVDPDTARRLAAAVPAHVLTVGVFRETPTDEVRRLTVESDIRAVQLHGDYPRSAFENLASLDVPLVRAVTLTPETDVRVGAFGERMLLLDSPEAGSGHRWDLSSLTTRPAGDWLLAGGLTAANVAEAVAEARPWGVDVSSGIESSRGVKDHALMHAFVKAARESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J1</accession>
    <name>A0A7W7T6J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="Purple_acid_Pase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="SSF49363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030832540" evidence="2">
        <location>
            <begin position="24"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Pur_ac_phosph_N" evidence="4">
        <location>
            <begin position="29"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="155"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="635" mass="66808" checksum="7995C586BC5EDFB9" modified="2021-06-02" version="1">MLAVALAGTVVAAALALPGSASADTANVSRVILTPTATPTESQSFTWRSTDVGGGTVQLRPVGGSAVDIAAAAVDTSTLNGVDYTHYSATATGLTADTAYEYRVGTGTEWSRWRQFRSAAKSAKPFEFLYYGDAQIGLESTWPAVVAAANAKAPNSAGSVHAGDLIDSSTQIQWTNWFAGMGESAATTQVLAAPGNHEYKNDGALRNWKMNFEYPANHPGLTTIGALADRAKGDTDAARQTAAYFAHWDDVAKETVYFSDFQGVRFITLNATQSTGYLTPASLPACAVDCPEPDALWIEFQAAWLDHVLATNPNKWSVVTFHQPVYSSAEGRDEPLLRDNWVPVFEKHSIDLVLMGHDHTYARGYKNSDATATPGITTGPVYAVSNSGAKHYTLAPANDNVWTRNAATQVRRGQGVTTYQVISVNGDTVTYRSYVAEKTANSPEPHKVGDLFDSFTITKRNGTKFVTEAGIEAPVGDDEQRVKVTVPERAPGELVWSIDGGNGVVDLGTAKESGDHFAARGTLNPVRVTDTRITSAPWSLSGQVGDFTSAGRAVGGKYLGWSPFLGDNAGGAVAGAAVASGFLSGDGLARSATLGSAPAGHAAGSSVLRADLDLRLPITVADGTYRATLTLTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J7</accession>
    <name>A0A7W7T6J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="232"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="248"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="53066" checksum="F863B5A68AEA3E77" modified="2021-06-02" version="1">MSRWVDPAPFEGVRPRLPWWMLLPGKLKCLAVVVALAWLVVVALGRFVLTAVRYPVTFVAPLVAAWCVWRHGWWPVGLTCTGLAGVLALWAKVAPHSFRRLCWYRLVTEWRRAVVYAPRWRTVMRLAELTKDVRGREYRPSLRHVRSEGWRDRVRVRMIPAQSSDAWELRRDGLAHSFGARSCRIRVLRPRVVELDFMHSDPLSRSIPAPALVDVSSGVDLKRVTVGCTESGSSWRIRLQGNQVLGVGVQGSGKASVLWSIVWHLAPAIRDGLVRLVGVDPKGGMELGQCPEAFDRVVYDNGVQAVELLEDLAVQVKDRADRYRGVRRLWTRVDDEPFTVLVVDELADLVAYQSDQNLRERASRALQTIVSQGRAPGFCVLALVQDPRKEVVGFRHLFGTRIALRLDEPVQVDMVLGDGVRAKGAAAHEIDENTPGVAWVKTDGRGLPERVRAFHVTDTDLLALAAYLTDGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L9</accession>
    <name>A0A7W7T6L9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23257" checksum="EF44B4E4F9808141" modified="2021-06-02" version="1">MTSPLHLSLAAQAVEILRELVLTGELPPGSRVNEVGIAQRLGISRGPLREAIRHLASEGLLVLVPHRGAHVPSADVSEVRALFELRTALECAAAELAASRRTDTDVIRLKAVCESSRQAHTAGDKFPYRLDLAFHQALLDAARSPRIAEQVRLVQQRVVLLRSGLRDDPPHQHASLDDHDSLVVAVEAGDPTRAADVMRRHLARVCAQMLTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6R1</accession>
    <name>A0A7W7T6R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="41876" checksum="1EF62D3C75534C82" modified="2021-06-02" version="1">MYLSTVERPRKLGWKGLSGNVFALGTVSLITDVSSEMVTAVLPLYLVVGLGLSPAAYGVIDGVYTGATTLLRLVGGYLADKTDRRKAVAGTGYALSAVAKLGLLIAGTSTALLGAAITIDRAGKGLRTAPRDALITLSTPSGDLGRAFGVHRAMDGVGAFLGPLVALAVLAAAADSFDAVFVASFCVAAMGVVVLAMFVRDHRSTLPAREPVRVKEIGTLLRDSRVRRLVIAAAVLGLATIGDGFVYLLLQKREGLTIGWFPLLAVGTSLVYLLLAAPLGALADKIGRLPVMLAGYVALATAYLLIHSPLDGIPLHLAVLALYGTFYATTDGVLMALAGPALPERLRTTGIALIQSGQALAYLGSSVLFGLAWKYFGPETATRLAAAGVATALVTTAYLLGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X9</accession>
    <name>A0A7W7T6X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-demethylubiquinone-9 3-methyltransferase (Glyoxalase superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14709" checksum="24CD09AA286BBCA5" modified="2021-06-02" version="1">MNAPKVTALLMFQGRAEEAMTFYTSLFDDGEVLSVTRYGPEQPGVEGSVVHATFRMGGQFYMCMDSSMPHDFTFTPSVSLFVECDTEAEIDRVYEALADGGMPLMPLDDYGFSAKFGWLNDRFGVSWQLNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T707</accession>
    <name>A0A7W7T707_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21941" checksum="D9530D759EABA101" modified="2021-06-02" version="1">MTTAAPSIGQRVHSLNRPNMVSVGTIVWLSSELMFFAGLFAMYFTVKAQNEGHWPPEPTELNVPYALFFTVILVASSFTCQLGVFAAERGDVFGLRRWYVVTLIMGAIFVAGQAGEYINLVHEGTTIPGSAYGTVFYLTTGFHGLHVIGGLIAFVYLLVRTKLSKFTPAQATSAIVVSYYWHFVDVVWIGLFAIIYIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7S7</accession>
    <name>A0A7W7T7S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="35998" checksum="479B23D359DA3E5D" modified="2021-06-02" version="1">MHVLIAPDSYKGSIPAHDAATALARGWSRTRPRDTVARLPVADGSDGTVDVLARAVPGAIRVPVPDVTGPDGRPLDAEWLHLPDGTAVVELARVGGLPLTAEPDPLGAHTIGLGELMAAALAESPSRLVVAVGDAAATDGGTGALRALGARFLDAFGTELPPGAAHLTRLHRVELDDLPEFPRIDVLVDVDHTLKEAPTTGNHATPHEAKLLSTALTRLAEALPHPQIPGTGAAGGTAYGLAAALDARLTPGADFVGTLLDLPAHLAQADLVITGEGAYDATSQRGKAVGHILTLARTTPKALVAGRLDIPPPPVPTVTLVSLATRRAAAFTHPVPHLHTAAAILARTLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G1</accession>
    <name>A0A7W7T8G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11368" checksum="8509333807F0D675" modified="2021-06-02" version="1">MGDQQKASAQWEGAYRRFTEASERSRYSGPDDPDAACRLASAYRSVAWSWRQLASIKTIPWWAKAAALHAADTFDQEASLCERVADSSATRERSSERGGNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K9</accession>
    <name>A0A7W7T8K9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">F4559_005931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="45"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="30700" checksum="99C10AC0EB3CBB21" modified="2021-06-02" version="1">MTETSSSAGPGSSLLGPADVRRLAAELDIRPTKKLGQNFVHDPNTVRKIVAAAELSPDDVVLEVGPGLGSLTLALLPACRSVVAVEIDPVLAAKLPETAADRAPDLARRLHVVPADAMKVTAADLPVQPTALVANLPYNVAVPVVLHLLAELPSLRSGLVMVQAEVADRMAAGPGSRVYGVPSVKLAWYADARRAGPVSRSVFWPVPNVDSALVAFTVRDTLPSTVDRRALFTLIDAAFAQRRKTLRGALAGWAGSAAEAERLLTVAGVDPGVRGEQLAVSEFVRIAEASALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M9</accession>
    <name>A0A7W7T8M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook-length control protein FliK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="682"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="795" mass="77409" checksum="190BE1F80AFFA1AA" modified="2021-06-02" version="1">MTTPLIQSTPSRPQQASTRSRGEGEPGFHAAFAASLSTSAEESTKDHGGVAGAPADRTPIPVGGVPLPAPQPEPAADPTVTEAAVAVLRHGTVVATAATATAVEADAKTDPNTDVKIDVDVEAEVGTGAPGLDAQVALGLQAGLAQLAVPAPVVRTTTVPVADVPTTKVAVVGTGVVDAAVVDAAVVNTAVMNTAVADAAVMNAVKANVAVVTPVPPMATPDVAVPGTPPTTGAVADSAVADSAVAASAVVSDTVVAGPARPEPVAVDARAAGEGFAGPGLPVESVVPTATATPSAVAVAAGTPQVAAIAVPLTRTTPTAPEVVVPQAVGTPDAPVGLGARIGLLAGLALQADTSVSVATPQPAVPSQAPTGRVVGIDALAAALPGDVRIAFTQALGTPAATPVVDAPVTQTPKPVATPVAVATPVTVAQVAGAQVATATATVAQATPETGQTATTPADGTTPTAQQTTAPAGIARTGDTRTGGDAQGDSRNSGSKGQETPASAAAGHTTGGSPVDGSQVTAPRTDGALVSRTSADAEAPTPVTRPSTADAVGITTVTTAVTTSATTSATTSATTAADPVTTTASTAATPAATVGDPTAQATAEVAPETVRPGNSPTPGPDTTPAVVEPRHADAGLPVVPQQVPAPTTPTAPAAIAHAPAPHHPVHPVATQVGSALVALGVGEHELTIHLHPADLGPVAVTAQIANGEIRIELGGGTEAGREAIRDALPDLRREMERAGFASCRFDLGTAGGDQGRRTWADPRPAWAAGREATDTATEATPVIRRPSRGVLDLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T3</accession>
    <name>A0A7W7T8T3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">F4559_005456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="66"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="308"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="44498" checksum="BED83292277B4BA3" modified="2021-06-02" version="1">MPNTPGTDPGRLPLRTAAAVRLGNISSKLSQKMGLGAGGMIGGRVALKLDPQALAHLTSGREVALVTGTNGKTTSTMMLSRAVSFLGEVATNHGGANMPDGHVTALSKQPDAPYAVLEVDEGYFPEVVRAAAPAVAVLLNLSRDQLDRVGEVRTIEKSLRTALSTVRGVVVANCDDIMVTSAARDCANVVWVATGTGWHNDAASCPRCGDPIQWRGEHWNCTHCDLARPRPNWITGDGFLIGPHGEKVQLALRLPGKFNQANAVMATAAAAALGVPVEEAVQRLRGVSNVAGRYRTIQRSGHRARLLLSKNPAGWSETLTVVREADHPAVLVINAHEADGRDLSWLWDVPFEKLRGRQVIASGERATDLAVRLTYAEVEHTIVPDPLKAIDALPTGPVEVIANYTAFRDLNARSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8U3</accession>
    <name>A0A7W7T8U3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ORF">F4559_005471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="26915" checksum="D699560567BE93B1" modified="2021-06-02" version="1">MLRTDGRNDDVLRDIRITRGYQQWPAGSVLIEFGNTRVLCAASVTEGVPRWRSGSGLGWVTAEYAMLPSATHTRGDRESVKGRVGGRTHEISRLIGRSLRACIDLAALGENTIVIDCDVIQADGGTRTAAITGAYVALADAVTWLGAAGRLADPQPLSCAVSAVSVGVVDGRVRLDLPYEEDSRAEVDMNVVATDAGTLIEIQGTGEGATFARSTLDRMLDVALAGCAELNRLQAEALAAPYPGVLPEPKGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T984</accession>
    <name>A0A7W7T984_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="36924" checksum="76A6FE9EE84A3830" modified="2021-06-02" version="1">MPREPMSVVDRGAACLLGGALGDALGAPVQYLGWTDIQRDHGPDGVLEPPRPALVTDDTQLTLFTADGYLRAWVRGRTTGEWEPVDMVWQSYRRWLVTQQVAAPELGVTGLAGDERLYSSRSPGLTCLRALAADDPPTPEAPHNESSGCNGVTRTAPAGFAPSAEIAYDLGCRFAALTHGGTGGWVAGGAFALLIHLIAVRGRPLREAVDQVVGRVLRDDPYTANTLNRAVVFAEEHVAQNFESVRVDRLGSGWTGPEALAIAVHTVLVHPRRAEVATALRAAANHSGGSDATAALTGNILGALHGTAGLPREWLANLELVDLLTRLGSDLGRSVVGLEFDEHRYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T998</accession>
    <name>A0A7W7T998_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="5" type="ORF">F4559_006290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="63"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="32413" checksum="E7C4450F4A691347" modified="2021-06-02" version="1">MTPGRDDVAIRVESPTEARNPRTGDIDRLSTLDLLHLINDEDRHVPDAVSAALPDLARAADLAVRALLAGGRVHYVGAGTSGRLATLDAAELVPTYNIPADWFLAHQAGGPDAMVRAVEGAEDRGDEGAARMRDHAAPGDLVVGVTASGRTPFVLEALAQARRLGAGTVLVSNNPSAPAPEVDVLITVDTGPEAIAGSTRMKAGSSQKLVLTSFSTAIMVRLGRTYSNLMVSMRATNAKLRGRTVRILREATGSSENECVNALSDANGDLKIALVHLLADVPISRATEALIHAHGHVRQALTLLSADATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y4</accession>
    <name>A0A7W7T9Y4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="30382" checksum="0A2002202601C4CF" modified="2021-06-02" version="1">MSSAFELRAPGPRGTPPLLARLVDDAALFPPGNATMPDAVRGHLDARVGPWAGAVGLFLCPASRLAELITELIKVKPVKPIALSLVIDTGLGGVPKAVSIVESRSELLALRMVEMPAPSDVDEVWLERVSEFVPEDVIRVVEPRRGGAEWLDGVRRVIEHGSWPKIRCGGLSRENFPSIDEVADFLAVVSGGGVAFKATAGLHHAVRYTDEKTGFTHHGFLNLLVATVRALSGGDVRAALDSTDSAALGEEAGSLSDQAAHAVRGVFASYGSCSLEEPITDLEGLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA89</accession>
    <name>A0A7W7TA89_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="30194" checksum="DDAE8648F4A308AB" modified="2021-06-02" version="1">MTGEVVLALDVGGTKIAGALVDGAGATRRFVRRSTPAVDVWPVVAEVVEETLDGTSVSGVGIACAGPVDTTAGTASPINVTAWQRFPLRDQVRALVPDVPVELAGDGACMALGEHRFGAGDSRFLLGLVVSTGVGGGLVLDGRPYGGRTGNAGHVGHVVVEPDGEPCACGGRGCVETVAGGPRMVDWARRKGWQAPENADAALLAAAALAGEELPKAAFDRAGRAVGLAIVATAAVCDLDLAVVGGGVAQAGDLLLDPVRAAVADHAGLSYLDSLRVAPARLGNRAGLVGAAALVLSAAPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAA1</accession>
    <name>A0A7W7TAA1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20669" checksum="BB1A83CBD5BC7227" modified="2021-06-02" version="1">MLIPYRLADLLLRLAEANTYRPLWSDEVLDEVERNLPRVGHRTPESARKFVDTIRWVFPDALVTGYESLTQVMTNDPKDRHVLAAAAYGGAAVIVTANIDDFPVAALTPYDLSAVHPDDFLLDQFDLYPDRTVECINDQICAYNKPTVTPEEFLDRLAKVVPDFVKEVRTPVLQARWRQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC2</accession>
    <name>A0A7W7TAC2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="31492" checksum="434EB0B8D13B11C2" modified="2021-06-02" version="1">MTTYADVEDPAVGLRAAAEDRPGRQTTRELIEKAGWKIQGVNWIYEQVTGENLIEALISPLLGDHEKIDANANAWDQVAKALDSVRHNVGAGVEQLSPHWDGDAAQSFERRLSTMWVVAIEADSQIARIIGNKFQSVAKTCRTATGLALSLLDKLVTKLMEAAMTAWIPVVGWGRAVWMVYDAVQIADAIRKIIIAIQTLIEGVKGMVDGIKAMGTALMKLKDVRDVNGLLDVLDGYQDGKQKFDNGVSAVKSGAIGTVWNGYKLGKAGSAANGRYQPAPAPAPAPEPSSGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT54</accession>
    <name>A0A7W7WT54_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000078</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="367" mass="39279" checksum="85ECE5E2C5B37EE9" modified="2021-06-02" version="1">MDRATRLRHELVDHLVSVGALRTPRWVDAFRQVPRHVFLRAFFVRHDDGSWSAVTDEHPDHLDLVYADNVLVTQLGGTTTAWQAHRARGTPTSSSSMPVIMAIMLEALAPEPGARVLEIGTGTGYNAALLAQALDDKAVTSVDVDPEVLTHATESLALAGHAPRCVLGDGEQGHPPDAPYTHILGTCAVDRVPPAWLAQAAPGGVVVTTLNRSLGAGLVRLAVHDGVGTGPVLADDGRFMPLRAHTPTWADALLAEAREGGDVRLTELPGSTVVDPTAGFEFFAGVCLPGVVAGLDPVRLVAPDGSWARQNGAGVAQSGDRRLWDEVEAAYRTWLSYRRPRRAAFTYTATPTEAYFTHPPTGRTWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTH2</accession>
    <name>A0A7W7WTH2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="449" mass="45693" checksum="AA16F608BE8EE68E" modified="2021-06-02" version="1">MPEGHRWSGYSHQELYEKIHAGPGPQASFASIERWAGIADALTDIDADLHEGILRSGAHWEGTAADQARHTMNPLASWAGNAREGADTMKLSAELQADYIAKARAEMPAPVKVTAPEAGGLETFLTHLIGGQTDNEIQEKARDAAEERAREVMATYASSTSGNTATLGTFHQPPQMSVQAPAVVRNENQHVFHHGWGWGGPRGGWNGGWRGGRPGSRQGSGWTRRPVPTWTGGDTRPSWTPPSGGATTRPATGPLVPHHGPTGGPGAVIGGGTTRRGDDQDRDRDKRSSTVTTGHNDTVSSGTSSGSGSGGSGSGSGGSGSGGFGSGAGGAAAAGAGLPLPSGTTTASSAEFGAFAAANAQQSTLGPGSASGSMLGATGAQGGGDTVHKRSTPAPAQPAFDPFGVGPQAAEDEEDEVHEAADYLRETDDVYGVGGMISPAVIGESPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTJ4</accession>
    <name>A0A7W7WTJ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenical pump membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_000604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="10"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4963245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="39485" checksum="02A8DBD662E663BA" modified="2021-06-02" version="1">MDFLRFGLLVAGVVCVATGLLPVDEAGASLSRIAPLLLFLTAVIVLAELAREARVFDVVAVRLAVLGRGFTWALFLLCVAFAATTTVVLNLDTTAVLLTPVFLALSVRIGISALPLAMTTLWLANTASLLLPVSNLTNLLAAERVAADPFAFAGRMWLPQVVAVAVTTVVLWVCHWRRESVRYTVPAPVVLVGRERALFRWNAGACVLFVVAIPVLRSEVEWAALGAASVAVGAFLVHDRRRLGFGLFPWRLLVFVSGLFLVVPTVSRYGLSDALAVIGSGDPLRTAAVSAGLANLINNLPAYAAVEAVVPAADLPAVLIGTNVGAVVTPWASLATLLCLEFCRAHGVRVRVWRLVGEGLVLASVAVTACALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTL5</accession>
    <name>A0A7W7WTL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN reductase</fullName>
            <ecNumber evidence="2">1.5.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.38" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="17260" checksum="5006F9893F9AD7DF" modified="2021-06-02" version="1">MTHVVGTLVGNPRPGSRTLNAALALSDAVRTASGGSAGPVVDAAEIATELFAPGSTAVRDALESLSAADILVVASPTYKATYTGLLKAVLDQAPGGWLRGKTVVPLLVAASDRHALAVELHLRPVLVELGGSVPGRGLFLNESALAEPAGLTAGFAELLTEAGWFTTPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU45</accession>
    <name>A0A7W7WU45_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28323" checksum="D99ED68A04F16C35" modified="2021-06-02" version="1">MTTFGVDLGLDDVREPVSVSVLEFDVLWEHLRLESMPLVLKVPSPGKTTSERSRLEREAWSGLDGRGLGSPAGVDPLLEDLLHLLNRPEREVDGRLWLGRSVRVLAAAKGGSGVLAVLADGRLTLRPASAEGLPREALSALPPLPAGPGHSITLPSADLDAAAAAATTPDTLVAALTSRGLRADDAKTLATMFADADHRGQFGAAHRDKWGKRHRPDHVIGFFDTPHGRYLQQRRATPGHPPWSTISPTDHRRLLSHLTPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU65</accession>
    <name>A0A7W7WU65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="13409" checksum="3124FE63EBFAD70D" modified="2021-06-02" version="1">MRVLGREPAYWMSLCAALLALAGAFGLPLTVEQQGLLNALLAAVFGAITAALVAAEKSVPALVGVFKAAIAVGLAFGLRLAPEVQASALVVVELVLTGLLVRPNVVASVPPSERLAMVGPDGVQHATFGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUC4</accession>
    <name>A0A7W7WUC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030863654" evidence="2">
        <location>
            <begin position="29"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21143" checksum="E28989EEE24A48EF" modified="2021-06-02" version="1">MRRLVIPFLVAALAVVGGCSYKVNGAPVSTAPLEVEPPFGGEDPSSTEETDPSSTDSPDPSGSAEPSAVGDVCSLIGWKDLPYDVPDKNAKPTDTGYDSSFDQSCKWQTHVDDLDVGVTLRFRESRTITLKDATGEVEVGGRKVAYSDRTTDTEVQPSCVLAMDYAGGGIGIIVIDGSARFGAICDQGKRVAELLLGKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH7</accession>
    <name>A0A7W7WUH7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16796" checksum="7FAE16B455ABAFE1" modified="2021-06-02" version="1">MSDLPRNLVIRDPGEEFTFRIGDHDLTDLPIAQHGPIIENLTPGHANPLYRAWVPFMVEGTIEDPQGLCRLVHDGEAELVGLPSGEQELTLRLPAEPPEGWHAIPRGGPHARRTFTRAGSRWAHTTDGDKPTWPELLASAGSAGVAVISPLVPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU2</accession>
    <name>A0A7W7WUU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH2:quinone reductase</fullName>
            <ecNumber evidence="2">1.6.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:NADPH:quinone reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="29662" checksum="A7193ABDDA6BF506" modified="2021-06-02" version="1">MTVGAAGVHLLDTSLRRGERGGPFPLPDLPLVPGREVAGVVSALGPDVPDNWLGRRVVAHLGQAHGGYAEQAAANVASLHEVPDHVSDERAVAMIGTGRTAFGVLRIAAPTADDVVLVTAAAGGLGSLFVQELKALGATVVGVASTAKLDLVRELGADHVVDYTAPGWDDEVRAEVGEVSLVLDGVGGDAGKAGLDLLGVGGRTVLFGWSSGTPTPVGTADLYRLGIGADVAVGPRIVKGTNLRELETLALDALASGRLTPRTTAFPLADAGRAHTALENRETVGKVVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUW6</accession>
    <name>A0A7W7WUW6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7120" checksum="77C04CE102C24A35" modified="2021-06-02" version="1">MSNAAHDEPAIWSEDRDGEHPAGEMSVSGRSRTGARARALAGLTLAVGAYAVVAAGVVESTSVSAPTLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV50</accession>
    <name>A0A7W7WV50_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan 1-alpha-D-glucosylmutase</fullName>
            <ecNumber evidence="3">5.4.99.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.15" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047470">
        <property type="term" value="F:(1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013797">
        <property type="entry name" value="Maltooligo_trehalose_synth_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="18"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="714" mass="77270" checksum="FCC22038177613F8" modified="2021-06-02" version="1">MNAPSSTYRLQFTPAFTFADAEAVVDYLDALGVGALYASPLLEAVPGSTHGYDVVDPTRARTDFGGEPGRVSLCAAVRRAGLGFVVDIVPNHMAVDLETANAWWLDLLAHGRESRYAKYFDVDWDAGLVLPFAADASGEVDRGTYRVIDWRRGDAELTYRRFFDITTLAAVRVEDPEVFAATHDEVLRWVAAGDVTGLRVDHPDGLSDPGGYARALRARTDAWLVVEKILGPDERLPASWPVDGTTGYDALREVCGLFVDPAGEAGFTALAAAYGVPTDFARVEHEARERIAAANLRAEVRRIAALVPHPDAERGVARLLADFPVYRSYLPEGRAAWDAAVAASTSPAVRVIDEMVRADPLGELATRVQQTSGMVVAKGTEDTAFYRYTRFVALNEVGGTPDRFGVSPAEFHRRAAEREAGSPHTMTALSTHDTKRAEDVRARLAVLSEIPDEFAAAVRRWTAAHPIDEPSLNLLAWQSLVGAWPITPARMAAYLDKAAKEAKIRTSWTDHDEEFEAAVAAWPAAVLDGPLAGDVAEFVAGIMAAGWSNSLGQKLVQLTAPGVPDVYQGTELWDLSLVDPDNRRPVDYGVRRRLLARIEAGDLPAVDDSGAAKLLVVHKALRLRRDMPESFRGYRPLAASGPAAEHVLAYERRGLVAVATRLPVGLAAGGGWRDTVLPLPPGAWTDVLTSRPASAALADLLDRYPVALLVRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV80</accession>
    <name>A0A7W7WV80_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron complex transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031362044" evidence="8">
        <location>
            <begin position="28"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="30034" checksum="90EC3F5A89DCF1FA" modified="2021-06-02" version="1">MVFARVSGILVAVAVLAFLQLSVGSTAVPLFGGDDHARAVLWELRAPRVLVGLCAGACLGLAGTLLQAAVRNPLASPEITGVGSGAVLGAVAASVSGFTQPLAVAFAALLGGVVGGGVLWVVAGRSGDVAVRGVIVSAVLVGTTLVLLTARPQLAGAVSRWLLGSLVGRTWEHVAPLWPVVVLVVVVGTLLGGVLDVLAVDDDHAHGVGLAVVPWRSTVLVLAAVATSASVAAIGATAFVGLLAPHLARWLVGPVHRVAVPVSALAGAGTVAAADAVGQLVHVPAGAITAVIGSGVLIAVARRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH5</accession>
    <name>A0A7W7WVH5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19823" checksum="9C819B3CBE4DF761" modified="2021-06-02" version="1">MNSPNADDRVRAVFDRMVADGLRRDSFQGASDERIDRMAAEQGVARVPEAVREVLRLIGIRSGLWLAGTAFGVEEMTGERKRHAIASLGGLDHDLVDAEGLLALTAHQGYAYHVVDGADLDRDDPPVWSVVEGESVTKAWDSVSRWFAATAPDVADLRDVLDVMAEMGKNLPAWARDVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ0</accession>
    <name>A0A7W7WVQ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate/phosphite/phosphonate binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005770">
        <property type="entry name" value="PhnD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01098">
        <property type="entry name" value="3A0109s03R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030607481" evidence="3">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32017" checksum="35E3D2818F1B82C5" modified="2021-06-02" version="1">MRRVVLLFVLLAACQAHTPPPPTVEDPLVFSGIPTGSSMTVLQAFQPIIDMLRRETGREIRIQDTTSYDALIEGVRDGDIDIAAFGPLSYVLAKERGAPITAVAAQTKEKGKTPGFRAHGFTRAGSEVHTMADLRGRKVCFVDQGSTSGYLYPAAELQGLGISPTTDVEPVFVGSHEASVLAVANGDCAAGFAFDEMVDRHLVERGQIKAGQIVTIWRSDLIPGAPIGISDRLPDTLRDTMSRAIREKANADYLRANGFCQGECPLGDADAYGYTPVDDHFYDKVREVCKRTTCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR0</accession>
    <name>A0A7W7WVR0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6292 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046259">
        <property type="entry name" value="DUF6292"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19809">
        <property type="entry name" value="DUF6292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6292" evidence="2">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14246" checksum="64E8D2B0551F45B5" modified="2021-06-02" version="1">MRVKQSARSGEPDEGGDGVAEWDFDDSGIRALRQYARAVGVALSLGGDCWCVEEEPRGGIYLPLDGRVAAFPEHDVALLWDEKAGWSASLETTGGADVVLERFTGPAKASPADVAAWAADLLRTEAVDDLTRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU1</accession>
    <name>A0A7W7WVU1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13490" checksum="CA49367B2529D769" modified="2021-06-02" version="1">MNIDTALKEAMSIAGAVGVALVDYDSGMSLGTSGGGDWLDLDLAAAGNTEVVRSKLRVMSTLGLNDNIEDILITLHRQYHLIRLLSGVKFRSSLFLYLVLERDHANLALARHQLKRIEVDLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU2</accession>
    <name>A0A7W7WVU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylamine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="PTHR11786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="19238" checksum="6E6B189AAA328C01" modified="2021-06-02" version="1">MSPDVRPDLAGLRVLQRAMTGSVSYENIDIQLRVPLSLAADDLVDKIVTRRRGGFRYEKHALFFLLLRALGFDVTAVRGAIERESRGDSAWRNPMPLLVALDGARWIVDGGLGDGFVEPVPLRTGAHARSRQHYRVERLGDDLWRPHHHPGGSTPPGDVRFGDHAPGPRPPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX6</accession>
    <name>A0A7W7WVX6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27131" checksum="BC83E21EA0817085" modified="2021-06-02" version="1">MHSLVKCTRRNFITNMAVFRQSSADHDRGVNPRTNIRRQKPDMTTHHETNISRLVGDDHSACPNRPHRAPSSPLPTPRAPPANGNTGSRAGRHPCTAAHLRIARQQNSGARETPVRQGRPPARPRKRLGRIHTAQCGRSGAPVSRSSPERVVTRPPRVGGTHRETCRPAAPRGMARLRRAPRTPRRRVDHHRGTAARQPRRSTLGLRAKRYSRLGSRSAHPRRAFGGDAATVRCLVGRDAYSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW03</accession>
    <name>A0A7W7WW03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031094001" evidence="2">
        <location>
            <begin position="31"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="11836" checksum="CFDC211210903CAA" modified="2021-06-02" version="1">MPPTTSRALVLLLGVLLALDAFGTHEHAFQAHHPAVEALDGQRAPGHEGDPHRSPVRVEAAPAKAVSDRGPAPSATPATCASPRIATRPTHPPAPVPGIAPVTDLLTLFCVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWE9</accession>
    <name>A0A7W7WWE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="515" mass="54703" checksum="99B06A68D15D3E7D" modified="2021-06-02" version="1">MDAIGDRLRGRLASPPDEPPAGLPDRDSLDRALSGAGSGDFDAARELWSLLSPIGRHADADLVVRRLAEAGPRLWLTVDAAARSLPWGILTSTDVAAHRLVAGRAGPLDLIAAACHPDGFVREAAVTVLGSRDNVSGVPVLALRAADWVPEVRAAARRACARQLDRAPTEAIALAAPVARAVHARRDGDWLLDAVADVLRDGPPEALEAALAAEDRGVRRLAHTIGLAAGRLHLDRLVRTAETGPDPSIRVLCAEAAIRAAGDRDVPRRLLAAGTAMVRAEAVRALAAAGEMAAVDAALVDTGAVVRATAQALLRRAGTDPAARYRALLDRRPPLPTVIAGLGETGAHVDVEPLREWLGHPSSRGRAVTVRALRRLGETTPGLLLPLLTDPVSSVTRQVVLSLLRHADGLDEDFLRPLLRPERPPHVQRAAYRLLRAHGLWTRIGVDLDLLADPGHPLHATARADLSHWLAHEAATAYAVPPASRVAELSALLADVEEIFGTDTRLLRFHIGLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWJ9</accession>
    <name>A0A7W7WWJ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031461856" evidence="1">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15515" checksum="12394FE7D4820F5E" modified="2021-06-02" version="1">MNRPRIVAAVLLVVAVGATQASCAKPALTVTATSTSASMSAITPALDLFGTAVAQDLTGLPDDVQAENVRVLIYRATAVVRELRRRPDADRVQEGIALGDAVSELSSLDRLDPANRQRIIDAARALDRWLRETVPGYPPTITPTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWP8</accession>
    <name>A0A7W7WWP8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
            <ecNumber evidence="2">1.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.193" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="3">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26011" checksum="2D3431C9FB0139B2" modified="2021-06-02" version="1">MGALSVDDLVGRDEWEAVNRQQQRPFVVYKFAATLDGRIAAEDGTSQWITSPESRAEVHLLRAGCQATVVGSGTQQADNPNLAVRGDDDPRLDLSIVTNPDRQPLRVVIDSNAKTPVDAKVCDDAAPTLIVVADDADSSHLDDVVDVLRVKRTGRGLDLDAVLQGLFARGIQGVFLEGGPTLAGSFIARGLVDRVVNYIAPALLGSGKSGLEDAGIRSMSGILRLALIDVARSGPDVRVVARPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWS5</accession>
    <name>A0A7W7WWS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent dihydropyrimidine dehydrogenase PreA subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="11651" checksum="505D390F78CB62F3" modified="2021-06-02" version="1">MIELVSAQRCIACDKCVKVCPTNVFDLGADGIPVIARQDDCQTCFQCEANCPVDALFVAPTTAPLPVPPTVDDLGGLLGGYRAQIGWGRGRTPGAARAVGPPLGPTGRSSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX00</accession>
    <name>A0A7W7WX00_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031434202" evidence="1">
        <location>
            <begin position="35"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="38375" checksum="7684377CDF57D834" modified="2021-06-02" version="1">MRRLSLRVVAAPVVLAVVLTGCGTTVEGRGVASAPAVTTTVPPTTTTSSVAPTTTTTAVTTTVPAAPPDRPGNPAGTAAVPAQAAAVDTSRPTTVIGDGTPAGCTSEAVVAAVAKGGVITFSCGPAPVRIALTATAKVRNDAPDVVLDGGGRVTLTGSGQRRVLYLNTCDQAQVVTTSHCQQQDEPSLTVQNIAIADGNSSGDTTEGGGGGGLFAHGGRLRIVNARFTGNRCDKVGPDLGGGAVRVLGQSNPVYVVGSTFSDGSCSNGGALSGLGVSFVVLNSVLDGNTAVGTGANPARDGTPGGGSGGAIYTDGNKFDVRIAGSVVEGNTANEGGGAVFFVSNDRSGTLSVEGSTLNRNTSKGFETEGFPGIFFLGAAEPKVANSTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX58</accession>
    <name>A0A7W7WX58_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="148"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="38268" checksum="16E1F5590452B3C5" modified="2021-06-02" version="1">MTMVAEPEVTAPPAVEEVRRRVGGRTLDDVLAALGSAFGSLALVWVLYQNLLPTSGRLGFVVCWYLAFLLLYAAVTALRHPRTVIADRLAAAVVHGLAALLGLGLLLVVGYTFWRGAEALGYGNFFVQDMRTAGPLDPLGRGGVLHALVGTLVQITIAVVITLPLGVGCAVFLNEVKGPLARPVRTVVEAMTALPSIVAGLFIYVTVLVFAGFDRSGLAASLAIGVMMLPIIARAAEVVLRVVPNGLREASLALGASQWSTVWRVVLPTARPSLATALILGIARGIGETSPVLLTAGYTTYLNVDPTSGPMVSLPLVTYSLARSSEKVDQVRAFGAASILLALVLLLFVIARVVAQRSTKGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG4</accession>
    <name>A0A7W7WXG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="24726" checksum="D86C77369234F9B4" modified="2021-06-02" version="1">MRVRLDPRQWPGRVVPETEDEIDTAVEAVCLRANWADADRTALRALVRPWFEAGWSVDALLTAADRRPDGTRQGSPKTHDQVAHDFLRARLRSWWEGGARRSRPPVAGMTLGQWWRVNRRNARLNEPRPRRVLGAPGESAREASLDRVRARLRDPVERARERGRRYTEVLDSLLVPGLSPPTFDDSRRLLAEIQVRVPRHPVCSRCGCRPNVLSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXT8</accession>
    <name>A0A7W7WXT8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="436" mass="48150" checksum="662F805F49B43771" modified="2021-06-02" version="1">MSDAPLHDEEFWSQPELRQALRERHIGRVMRAYRQAQSPEVKQVDLGRWINLSQGQLSRVERSSVAVTDLAKLIPWAEAMRIPRHLLWFTWPDMEHDEAEEGPEVRRRDVLKAAGIAAASVELITNSPWQRLQDSLDQERPVDDATVRLMRDRTADLFQTEETVPASQLLDSLEGHGNTLQSLIKNARSDRTRRDLVVALGETKALTGWVLFDTGRGNEAANAWRETLKIAKAVDDGALAACALGYWSYLAASRNDTGPASKLLHQAHDMVPGSSAPATRSWIAARQAEELARLGDETGALRSIERAITAYDFAQPRTERSWTGFFSASRLGSMTVSTYTIMRHRDADAVAGSLLDSLSPRDNKVRALILADLATSAASTKDYDKAGELATQAGRLAVRTEASLAKTRLLTLASTLPTTRTGPETALRDRIAVALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA2</accession>
    <name>A0A7W7WYA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33457" checksum="3E54C3FCC02CB230" modified="2021-06-02" version="1">MTVLIIDVRDLRMRYGTNDVLHGVAFGADRGEVVALLGPNGAGKTTTIEILEGFRTPSSGTVRVLGVDPATGDEHWRAKLGVVLQSWRDHARWKVRELLHHLGRYYTPYGTTEHPRPFDTDELIATVGLTEHAGKKIGSLSGGQRRRLDVAIGIVGKPELLFLDEPTAGFDPHARRDFHDLVHRLSDIDGMTILLTTHDLAEAEKLADRILILAGGRIIADGSPDQLSRRVKATSEVRWTQDGRRHVHPAEDATAFVRDLLGQHPTDISELEVRRSTLEDTYMALVQRFESGHADEAEVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE1</accession>
    <name>A0A7W7WYE1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14880" checksum="C6CB22EF140AA4B7" modified="2021-06-02" version="1">MTRLELAVDVAAPAATTWAAATDWVRQGEWMLGTRVRVTGGDGTSTGSTLSAFTGIGRFGFVDTMRVTVWEPPVRCVVEHTGRLVRGTGGFRVSGHGDRSEFVWYEDVPWPLAAAFAPGVAWSLRRFARFAERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG3</accession>
    <name>A0A7W7WYG3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="362" mass="37609" checksum="9E6640D390C70DB3" modified="2021-06-02" version="1">MTSRTLPDFPWDSLTDHAATARAHPGGVVDLSVGTPVDPVPEIVQRALASVAEVPGYPTVHGTPALRDAVVAALTRRFGTPDCDPAAVMPTIGSKELVAWLPTLLGIGPGDVVAIPALAYPTYEVGATLAGATTVRLEDGEAPPPGTRLVWLNSPSNPTGRVLDADALAKAVAAARAVGAVVASDECYLALPWTGEPASVLRDDVSGGDLTGLLAVHSLSKSSSLAGYRAAFVAGDGRIVGDLVQTRKHAGMIVPRPVQAAMIAALDDDEHVAVQRERYRARRDVLLPALTGAGFRVDHSEAGLYLWATRGEDAWDTVAWLAARGILAAPGTFYGPTGGRHVRIALTATDERIAAAVERLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN9</accession>
    <name>A0A7W7WYN9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone/menaquinone biosynthesis C-methylase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="20848" checksum="D8CB66398B28AE47" modified="2021-06-02" version="1">MAANLAKAFDLAFGHPRGKVGELGGRVMAKTGAKAEAHAVEVAAPAPQEVVLVVGHGPGVGLRLVGEQAIKAIGVDPSSIMLDEARTRCADLIATGRVELREGTAARTGQPPASVDVVVSVDNLQLWENRAASFHELARVLRPGGRLVVSVRRWRLPVSEFDLMVEAETAGFVDVRTSLQHYGGLQPPVVLLLASTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYS2</accession>
    <name>A0A7W7WYS2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylyltransferase/sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="298"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="41972" checksum="E3904EA83D0826AA" modified="2021-06-02" version="1">MALPPLVAPAAELTKEEVARYSRHLIIPDVGVDGQKRLKNAKVLVVGAGGLGSPALLYLAAAGVGTLGVIDFDVVDESNLQRQVIHGQSDIGKPKALSAKESVAEINPFVHVNLHQEQLTSANALDVFRDYDLILDGTDNFATRYLVNDAAVLLGKPYVWGSIFRFEGQVSVFWEDAPNGQGLNYRDLYPEPPPPGMVPSCAEGGVLGVLCASIGSIMVTEAIKLLTGIGDPLLGRLMVYDALEMSYRTIKIRKDPASPKITGLIDYDAFCGVVSDEAQRAAADSTITPRELKDKQDRGDDFLLVDVREPHEFEIVRIPGSVLIPKDRILSGEAFAELPQDKQIVLHCKSGVRSAEALASLHAAGFKDAVHVGGGVLAWARQIDTSLPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ24</accession>
    <name>A0A7W7WZ24_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc/manganese transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="28738" checksum="78BD6A4B73B6C6FC" modified="2021-06-02" version="1">MTAGIAERSVTSAVALRGARLAYGDRVLWDGLDLDVAPGEFVAVLGPNGSGKTSLMRVLLGLQPLSTGTVEVAGGPRRIGYIPQQRAISSLGLRGRDLVGFGLDGHAWGLGFRRRAERRIKVDAALAAVGAAAYADAPVGVLSGGEQQRLRVAQALVGDPAVLLCDEPLLSLDLAHQRVVSDLIDARRRAAGTAVLFVTHEINPILPLVDRVLYLVDGRFEVGTPAEVMTSATLSRLYRTNVEVVRVRDQIHVVGAQHVCEDEPHHAEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ42</accession>
    <name>A0A7W7WZ42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="85" mass="9338" checksum="73D241D08C68F99E" modified="2021-06-02" version="1">MTAEQVRAARAEGYAAGYALTPSRPNPYAPRHLPIWHDRRTATEKANAEKAEQPARILAGVWLRAHSEGLAAHARERELTLPSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ96</accession>
    <name>A0A7W7WZ96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045975">
        <property type="entry name" value="DUF5931"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19354">
        <property type="entry name" value="DUF5931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5931" evidence="3">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="256"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="36889" checksum="1BD7DB423ABD5FDF" modified="2021-06-02" version="1">MFALGNAVIQYDDYRRQWLAGAVIATMAVWSVFTIQAYSRRRGRRPWVVVADLVVTCALMSMSPLIMSDVQFLLNIPLITTIWACGPAVAAGALGGQVAGAVGGFAIGLSTYLNRGMISVDLVRDVVLLTGAGFVVGMASTTAKRASVRLAQALRTEAATAERERLARSIHDGVLQVLARVRKRGSELGGEAAELAELAGEQEIALRSLVAAAPTESTMDGDADLRPALQLLATPRFQVSTPATQVMLPTATAFELTAVVREALSNVDKHVGPAAKAWVLLEDLGAEVVISVRDDGPGIPEGRLASAEAEGRMGVAKSIRGRVEALRGTLELVTGPGEGTEWEMRVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC4</accession>
    <name>A0A7W7WZC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="357" mass="40172" checksum="EB1761002DDF0CCE" modified="2021-06-02" version="1">MLTHKDSVGVHPAASNAEYDYYAPSECGAFDPRQDEQEVRRKNHFAFCLVSRPRYRFYRYIGRFPVLVGEATFRIMLIGYGERGVRRMRFELDVDDWDGWGFQRDEAPLEIKTTCLNLPQAECDTVGGGRASTIRDWKVRGYDYATFVTARSPGGGDGANYDQDKVNYHQMRLEIVAPTGSGRFDQSFRCDSATYAGGGACIFHEVEAVMQYRLSGDGVDEIAAHIKKAQEDPGSMYPGGAGTAIPGGYTSGRPLTRLYSGMDDESRRYYDANNRIARNTCEKFDPNYGKPGLQCDEYPFRSTWEGAYSTAVDPQSRWKYSARMVDGDQNGKAGSDLGVWYTQDHILAKDAFWVSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZC6</accession>
    <name>A0A7W7WZC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="348" mass="37833" checksum="92F338B4562B8F1C" modified="2021-06-02" version="1">MRHIVRVNTVGEGYGLHVVDAGVVRRLPLDVPSPDLPPGFRTLASRADDFLGDVPGRAFFGATGTPAATTVLLGLRLDLPDEFGRRGLTLLHALVGDHTDLLDHVRAVGRLVSPGHVEPLAEAVARTATEEGDLARIVAVVEGATAGVRERARSGPPPRPLAEIVHDTSGAAVAWLGMVTANRRADAEWTVHDRRRADGTVATVSDVAGARLTLSDYLDLAVHAFDGDRPRAATPVPRPASTAPEPRPRSTARPPDHRVGVVDPRRTRGRRLAVLTTRHRYAITPRRVVTVTVYTDWYELWVFSPYDALFGRPVVPLYVANDGDPRFRAWLRDNHARFGSVRGQPTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZZ7</accession>
    <name>A0A7W7WZZ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15201" checksum="C42A55B2AE806CBE" modified="2021-06-02" version="1">MATWQRFEDEAGGLATEVRRIFLASRGHVLATLRRDGSPRVSGVEVAFQGADLTFGSMLGARKAQDLARDGRFALHSTPAEGGDAKISGVAVELLAEGDSHLFRFDLAEVVHTALGEDGKHLLIRLWRPGLAVEEFRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY05</accession>
    <name>A0A7W7SY05_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Murein DD-endopeptidase MepM/ murein hydrolase activator NlpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="144"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="25785" checksum="04E2816EAD34A012" modified="2021-06-02" version="1">MLDEAVDRAATRTVSSHRLPPPPSALRGRIVVAAVAVGAFAAAGAGQTLHALGSSSSGDEVTPLANSAPDGAAAFGVGGTAPSAPQIVPVAKTVDAQAEAQKLTKSQKITADREAADAEAKRPKYARPANAEFTSGYGGRWGEMHYGIDLAGPIGTPIYSAADGVVIEAGPASGFGLWVRVQHADGTITVYGHVNDYSVQQGQRVKAGEQIARMGNRGFSTGPHLHFEVWNPGGKKINPLTWLNENGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY58</accession>
    <name>A0A7W7SY58_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">F4559_000397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="202"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="37291" checksum="DF397E0A6144A30C" modified="2021-06-02" version="1">MSAPTEAPRPRVLSGIQPTAASFHLGNYLGALRQWVALQETHDAFYFIADLHAITVEQDPKVLRHNTRVSAAQLLALGLDPDRSTLFVQSQVPEHAQLSWLMQCLTGFGEASRMTQFKDKSARQESQVGVGLFTYPIMQAADILLYQAHYVPVGEDQRQHLELTRDLATRFNSRYGKTFRLPEPYIVKDTAKIFDLQDPTSKMSKSVPAGVVELLEDPKRSAKKIRSAVTDTGREIVYDPADKAGVSNLLVIYSALTGRTVDALVEDYAGKGYGDLKKDLGEVFTEFVTPVQESVAAYLADPAELDKILARSAERAREVAGKTLARAYDKMGFLPTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH0</accession>
    <name>A0A7W7SYH0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-acetylhomoserine (Thiol)-lyase</fullName>
            <ecNumber evidence="6">2.5.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.49" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="429" mass="45600" checksum="AC458057FFF53135" modified="2021-06-02" version="1">MSWSFETKQVHSGASPDPVTGARATPIYQTTSFVFRDTAHGAALFSLAEPGNIYTRIGNPTQDVLEQRVAALEGGVAAVAFASGQAAETATILNLARSGDHVVSSASLYGGTYNLFRYTLPKLGIEVSFVEDPDDFDAWRAAVRPNTKLFFAETLGNPRGNVLDIEAVAEIAHTAGVPLVIDNTVTTPYLLRPLEHGADIVVHSATKYLGGHGTAIAGIVVDGGKFEFSDPEKFPDFNEPDPSYGGLQYWPALGHGAFAAKLRVQGLRDTGAAIAPLTSFLILQGIETLSLRIEKHVANARAIAAWLEQRDEVEKVHYAGLPSSRWHSLASKYLPHGEGAIVSFELRGGVDAGRAFVDGVELFSLLVNIGDVRSLIVHPASTTHAQLSAGEQLIAGVTPGLVRLSIGIEGVEDLKADLEAGFRAAKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYM8</accession>
    <name>A0A7W7SYM8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polar amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17703" checksum="6D48EB671172858C" modified="2021-06-02" version="1">MSRSLGALDVRRVTLADPLVTPMLDELLFEYTTRYGPGAVDEMTRYPADAFEPPHGTLLLLLEEGVPVAGGAFKRYDARTAEAKRIWTAAAHRRRGLARRVMAELEREAASYGYRRMYLTTGPRQPEARDLYLATGYTALFDVANPPTVGPLPFEKDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ27</accession>
    <name>A0A7W7SZ27_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019139">
        <property type="term" value="F:cytokinin dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009690">
        <property type="term" value="P:cytokinin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015345">
        <property type="entry name" value="Cytokinin_DH_FAD/cytokin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09265">
        <property type="entry name" value="Cytokin-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="49"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="43925" checksum="4CD065FA8B23686A" modified="2021-06-02" version="1">MPVDHHHFDPTRRAVTTAPTPGSIPIPVATLSTAEDALTWAATDFGHTVHNRPHAVLRPTTEDEIADLLRFATRHDLRVVAKAEGHSTAGQAQSLDGIVVDTRALDTVHALDGDRIIVGAGARWSQVLAAMLPHGLTPPVLTDYLETSVGGTLSVGGLGGATHRHGAQTDNVLALDVLTPDGDRHTCSPGDPLFDAVRAGRGRHGIILRATLPLVPARSHALVRKTTHTKLADFLATQREQIGGRFDYVEGQAKLDDTGHWTYVCETATWTDTSTDTPYGAFLDRLSPDVALLRELGHWDAPHPWLNLLLPDHQAEPFIAHALTQLTRADIGQAGVVLIYPIVTTRITTPNLRLPDTPIAFLFAILRSAPHATPEHLDRMTAHNRDLTRHAESLGGTAYLGELPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ46</accession>
    <name>A0A7W7SZ46_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="182"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="426"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="521" mass="56067" checksum="BD50044BF7A0E338" modified="2021-06-02" version="1">MGGSPETNAMRLDGLLRELTDRTAQVLMSQERLHRLLGAVMSLASDLSLPDVLRRIVESSCGLVGARYGALAVMGPHRQLLEFTYGDDDHRAAFAGTTFDPAAPGFLGVPVHVRGEVFGNLYLTDKEDGADFTRADQEVVTAIAAAAGIAIENARLYEQSRQREVWLRASNEVTNALLTGTPDRDALRLVAVRARLAADGACAVLALPDEQGELQIRVNDGELRGFTMSREGSASREVFTTGRTMVLDGLPGHFDRIGPVVIVPLAAGDRQLGVLMVARARDRAGFGSSDVMLVEAFARQAALILEFTRASGVGRRLAVLEDRDRIARDLHDLVVQRLFGLGLGLQSLNGLVEQPLVADRLAEFVAEVDQTIREIRQTIFSLQEPPDGPNSLRGQLVRAVQDASRLLGYEPTLAIEGPVDSVVPDHVRPDLLATLREALANAARHASARMVEVAMRVDRDATEATLIVRDDGAGLPEGGPRHTGGLANMTARARRWNGTCVVDSAEGHGVTVTWSVPLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZI4</accession>
    <name>A0A7W7SZI4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13168" checksum="9901D82D811C7F42" modified="2021-06-02" version="1">MATYALPSDVATRLGLGGSGFDEDEESQALALLEDVSAVMRSRLPLLDTWITAGLVGADTAKAVACWLAMECITVATTGVGKSGETHPEHAVTIRSAAGLDLSDAQVAQLTPAGARGSGRPFSIRPGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZK4</accession>
    <name>A0A7W7SZK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="19788" checksum="AA59BF34160BBC4F" modified="2021-06-02" version="1">MSRRAVYLVVSVVCVFVMLGSGLFVNGSKAVVGVAIVLGIVYIFVQGTLRKKAWVLAGGLVVVVGVMYASVMFAMPLWLSFTGRTVDCEVVSKQEVRTSKYGRETRSELRCGDRDLTFTPYREPVGAAVGGRTSVVVDSAGLVSAVRPGEVHRLGLIGLPATAVLAIGFTLVVGRRPRIAQDGETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS0</accession>
    <name>A0A7W7SZS0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine/putrescine transport system permease protein/putrescine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="28852" checksum="02C2BC795B595BF0" modified="2021-06-02" version="1">MTRRPWVLGAVTALVFLFLYLPIGWLALVSFTESRSISRLGGFSTRWYAELFDDDRVLDALALTVRLAASSAVIATVVGTLAALGLRRAFPGRGVWTVLLGLPLVVPEVVLGVAMLGFCVKLVGIPLGFGALLAAHVAFSLSFVVVVVRSRLAGADPRLEEAAADLGAGPFTAFRTVTFPFLAPAVVSGGAFAFLLSFDDVVTSSYLTGVGSTTLPVHVYAQASKRGVSPEVVALSTLMVGVSAALLVAGVAVAAWRARQLSSASVATNDRRVTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T012</accession>
    <name>A0A7W7T012_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001461</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="479" mass="51070" checksum="07DC102F40DBB8D9" modified="2021-06-02" version="1">MTTETEPPRPRRRAAKAVGVRGSLTAWLGRPLADFHLLLAVFGVLTVLGLIMVLSASAPGEVADGASAYSVFQKQLLYVGVGAVMFLIVLRIPLRRIRNYSMMAMLVCVVLLGLVLTPLGTVAGGAQSWFTVGPVSFQPIEAAKLALALWGAHVLVTKRALLDQYRHLLVPVVPVALVVFTLVMLQPDLGGTITLGIVLISLLWFVSAPMRVFGVLATAAVSAAVVLAIGSPYRLKRVASYLNPEADPTGAGMQARQALFALAEGGFLGKGLTNGSSKWRYLPNVHSDFIFAVIGEELGFIGGMLVLGLFGLLALVGLRIAARNTDPWIRMVAATLTVWLVAQAAINIGYVVLLLPVTGITLPMISSGGTSIVTTMIVFGILASCARHEPDAVAALRSIGPGRVGGILRLPPPEAYKPPPKRKAVRPTPPPRSRRAATPPPPDERRVAGRSAPPSDYRRRETRRTPPTTGRRTGRDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T065</accession>
    <name>A0A7W7T065_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (DUF1778 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="18631" checksum="9E78831DE8D0AFD7" modified="2021-06-02" version="1">MDLSPYIAALREDLATAASAGDEDTRRTAAVLSAALEPAARLAIMNALSDLAAEVTVALDGPVVDVRLDGRDVQVVVTGTDSREEDEPRTQEVPRPSAGDATRITLRLLDELKAKAEQAAQSQGMSLNTFVAQAVQGAVGKRRGGHHGGHHDGHRGHQKHHRPDDGPSSVRGWVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T081</accession>
    <name>A0A7W7T081_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">F4559_000239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_073885923.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17492" checksum="7ECC2F70A47F8501" modified="2021-06-02" version="1">MPRKGPAPKRPLISDPVYSSPLVTQLINKVLVDGKRSVAERIVYGALEGAREKTGTDPVVTLKRALDNVKPALEVKSRRVGGATYQVPVEVKPGRSTTLALRWLITFSRQRREKTMIERLMNELLDASNGLGASVKRREDTHKMAESNKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q7</accession>
    <name>A0A7W7T0Q7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-dependent enzyme (Double-stranded beta helix superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17225" checksum="72F1009294BCBA4C" modified="2021-06-02" version="1">MFAVPENTIALPQTRAALHPVRIALDVAARRERWAHLLRYDPETRFSALVERTDDHEVWLLSWLPGQHTDLHDHGPANGAFTVVNGALTEVVASGRHQVLHHLTAGQSRVFGPSYVHQVRNEGPDPAVTIHVYRDGTRTLRPYHFDPLTGPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H0</accession>
    <name>A0A7W7T1H0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="6" type="ORF">F4559_002184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="30868" checksum="AF7347FF54EB4A7D" modified="2021-06-02" version="1">MRTKPTLTWTPTGPPRPRTTSLDEVVGVVGAGNVLVLSGAGLSTESGIPDYRGATGSLRTHTPMTYQDFVADADNRRRYWARSHVGWRLLAGATPNAGHHAVTALHDRGLLTGVITQNVDGLHRAAGTPDVVELHGGIDRVVCLDCRVVTGRLDLDRRLRDLNGEFSADASRVNPDGDVELPDDVVRGFRVAACADCGGVLKPDVVFFGENVPKDRVDRCYALVGAADALLVLGSSLTVRSGLRFVERAARTGRTVVIVNRGETRGDAHASVLVDLPLGRALTDLLTALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1M0</accession>
    <name>A0A7W7T1M0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="49"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35364" checksum="8B97EBD4D5427B2E" modified="2021-06-02" version="1">MKRTLVILAAFLVAATGWIVVAQDYDLREERVEIGDLRGVLAKPPGDGPFGLVVFVHGDGPIDATHDGHYRPLWEEFGRAGYASLSWDKPGVADAPGNWLHQSMRDRADETAGAITWARGRPDVDPRRIGLWGASQAGWVLPRLAATNTDVRFVIAVSPAVNWLRQGEYDLVTSLRGRPEAEVRAALDRRGRRLALLARDASYAEYREVDPDMTEDRWRFVTLNHRSDASADLAASRVPVFLALGDHDVHVDADETARVYADLVPDLEVHRYRDATHGLAEPAVEDSAVWGTLVALFAPRSVYADGVLDDQRRFLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R1</accession>
    <name>A0A7W7T1R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="30244" checksum="8816F7C3CC0706B2" modified="2021-06-02" version="1">MSVPPQQPGPYGGQPGQYGNQPDPYGSPQGPYDQQPPGQYGGRPGYGQQPGGYPPPPQGVPQGGQQPGYGQQSGGYPPPGQQGYGQPGYGPPPGGPGQPGQPGQFGQQPYGHPGGFGGPYGPPRKKSPLPWVLGGVGVLAVVVVLVVVFVFNGGGNSSPKEAADTFVAAFNAKDWDKLKSVTCAEDHSKIDDLKSKADPASMAAELEKAIQEAPPEMREQFKKIAEAAKNIKTTATVTKIEETDSTHAKATVKIKLENVPDEIKGSVKSDLEEDVKFVKKDDGWVTCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X2</accession>
    <name>A0A7W7T1X2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4333 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025637">
        <property type="entry name" value="DUF4333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14230">
        <property type="entry name" value="DUF4333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="3">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24699" checksum="5C21D08B678EA152" modified="2021-06-02" version="1">MTSPYGPSGGNDPQQQWGQQPYPGGYPGTPSGGFPAQQPGYGQPDPNAQQQAQWGQQQPGYPQPQQFPGGYDPNQQQNPYGQPDPNAQQQWGQQPGQYGQQQNPYGQQNPYGQQGYGQQPPRKKSGAVVWVIVALVVLVVAAFGITGFVTPGFLKTKVFDNVSVQNGVVQILKDDYKLSDVEGATCPADREVKPNTTFECTVKVGGTQKKVKITVKTEDGEYEVGQPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H6</accession>
    <name>A0A7W7T2H6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22133" checksum="23DDEB96E3A5AE8B" modified="2021-06-02" version="1">MADTRQRLIDGAIATIRTHGYAGTSARTIAASAGVNQALVFYHFDGVHDLIRAACLAATRARVAPFAERLDRITDLRGLLALGRTLHTAERAEGNVTVLAQILAGAQADSDLAEAAAAALNLWITPIEQALDRLLADSPVAEWIDTAGLARAVSAGFVGLELYEGVDPAGALAALDALDRLAVLVEVVDDLGPVARRALRARLRKAERPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U4</accession>
    <name>A0A7W7T2U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25242" checksum="F94579FA2667076C" modified="2021-06-02" version="1">MEPKTPGTFVEGLTPDDRSALLALGVEKAYRQGDVMLREGERTDHVVLLLRAIVKVTRTLDNGRFALLNIKIGGDLVGEMAALSGDPRSATVTACAESRVRIVTAADFRRYLADSPGAHLALDRMIMRTLMWADKRRVDFSCFTAQVRLARVLSELAEGYGRTVPQGVMIDLGLTQKEVGALIGVEEDTARKELRALRDRGVVRMGYRTQTIVDARALGRIAEGSWETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T309</accession>
    <name>A0A7W7T309_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kmo</name>
        <name evidence="6" type="ORF">F4559_002426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD biosynthetic process from tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="5">
        <location>
            <begin position="5"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="443" mass="48615" checksum="B89E7BE96B66E8D8" modified="2021-06-02" version="1">MSRTAVVVGAGLSGSLMSVYLARRGFAVRVLERRGDPRTPGVREEGRSINLGLSQRGIVALREVGLLDRLKPATVPMRGRVVHAPDGTLRFQPYGTEEDQVLHSVLRHDLNVALIDEAERLGVDFRWGHRVTAVDRTVPSVIAGEEHAADLVVGADGAFSAVRAQLARGLRMDLHQEYLEWGYRELLIPLDDGGKPRTDPYALHVWPGDDGLIVAHPNADGTLTATIFLPFEGPAGFAGLDTPERVRAFFADRFPDVPALIPDVVEQFLDHPPASLVTIRASPWHTATDDGRGTVLLGDAAHAVYPFYGQGMNAAFEDCSVLDRCLAAHPDDLPAALAAFERFRRPHTDVLAELSKRNFVELRDRVRSPLFLARRKADLLLHRWFPRAWVPLYTLVSHTTTPYGEALARVRRQDRLLGGVTAALTGAVLAGLAHRSRAGRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T354</accession>
    <name>A0A7W7T354_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26087" checksum="4280D25D2D7B0AFF" modified="2021-06-02" version="1">MSWSDAQYDELGERYERVKHIPSGLAERATLLQALPDLAGRTVLDVGCGTGFYPRLFRTLGATRIVGVDSSTEMLACARRAGDDIDYHHLDATDLPVLGEFDVVTAIWLLAYADDDAHLDRMIANLAANLTPDGTLALLIPNPDVDWDVVADYTRYGYRIVRTGPPARRQPVAVQVSGEPPFDFASYFWAPGAVEAAVARVGLAEPVRHPTVVPAGDPAFWADLRRSPAFAVLTTRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J1</accession>
    <name>A0A7W7T3J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5652" checksum="AE912DCC2A0A8923" modified="2021-06-02" version="1">MSYARITNPTGTVTLCPDGCDVPTVEVDLGDGRTCRVHCGTYRPACPTRPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V3</accession>
    <name>A0A7W7T3V3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl transferase domain-containing protein/NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_003456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033068">
        <property type="term" value="P:macrolide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041618">
        <property type="entry name" value="PKS_DE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015083">
        <property type="entry name" value="Polyketide_synth_docking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036299">
        <property type="entry name" value="Polyketide_synth_docking_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08990">
        <property type="entry name" value="Docking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18369">
        <property type="entry name" value="PKS_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101173">
        <property type="entry name" value="SSF101173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="907"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4456"/>
            <end position="4533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2757"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2761"/>
            <end position="2789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2854"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2932"/>
            <end position="2951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2958"/>
            <end position="2978"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="942"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="4493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="4604" mass="475735" checksum="65590C127D9DD72A" modified="2021-06-02" version="1">[encoded data, 4604 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T420</accession>
    <name>A0A7W7T420_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="36366" checksum="CA1EC162EEADF2EA" modified="2021-06-02" version="1">MLYLRSFKEDPHRGTPETHRALPLLDLTPPGVIHTLLTAGKSAEDHLASCFRDMGPVIAVGQPGERLPPAVGARRLYLEQGPWKNQVRDLISRARFVVLVADDTEGTLWEFAEATRLVPPERFLLVVPASEKAYEAFRRKATVLPRGDAARTGRDRTVPRLPVDPRIDSDRIGMALPHGFPFGGVVSYSPDREPVFTPLRVTPPALGMGLVGPTLWRTVRPAVERALDAEAVILKAHHDELYRTRKDLVFARRMHAVMLAGPFAFLAYLLIRWKWAAGEGLDGLSPEWWVSLISAVVLCGYRTYRHGVMRRTGVLPMPPSDGPGTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G2</accession>
    <name>A0A7W7T4G2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="36961" checksum="72789741E4974DE4" modified="2021-06-02" version="1">MADDVDRLIADGDRITAALLAMDDHPGHRLLRGASLTGASRTRWEETAAAMVVLWEWYDVHRALLARCRDADPDLLRVLLATPVTEVDGTPLTSAGLLARMTGRHAEITAVLDEAHARCADRVALLTTPADRLRALPDTAVVAALRVRVAAARERALSDPLTPDPEVAGLVDEVAAVHRLHEGFADRMAALDGVVEEVVATRERARVVRARVVERIAGDHPDVPGDDLARTVAAVRARFPDVLENDVAQVERTAATSRDRARAVLEQLAGTLERRAELRGRLSAYQAKATRTGHAEDAELSDLHRRARSVLYSAPCDLRAATVAVGRYQRAVLDRTEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4I9</accession>
    <name>A0A7W7T4I9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19073" checksum="0B805DF34B765BB5" modified="2021-06-02" version="1">MPHSDPVSVDAVVDSALKIQFEAFVDQHRAALRDSLDGLTEKQARRSLVASRTTLLGLVKHAAFVERVWFDEAVTGRSRAEIGIPATVDESFELTEDDTIASVRAAHEAACAASRRATEALDLDSVLPGNRRGPLPLRWVYLHVLRELAQHCGHADILREQILDGPGGATGTMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4L9</accession>
    <name>A0A7W7T4L9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="56" mass="6376" checksum="23C1B3A369F41995" modified="2021-06-02" version="1">METFDRIRQTVKAQAGDASVERVMLRRAGISLRFGTLDHCAFDECDPAGRPVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q0</accession>
    <name>A0A7W7T4Q0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="25076" checksum="B3AAE16569BD6896" modified="2021-06-02" version="1">MSVLSLADVTVERSGLAVVRDVSLRADQGAVTVLLGANGAGKTTLLEGVSGATPIASGTITLDGRRLDGLRAWRRARAGIAHVEQDRAVFRDLTLRENLLAACRRGTTPDRALDLFPELRKQLHVPAGLLSGGEQQMLVVGRALLGEPRFLLVDEMSLGLAPIVVERLAAAVRALADDGVGVLLVEQFAALALRIADRAYVMSRGRIVYEGDGATLRADHDLLRGLYLGEPVESGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T523</accession>
    <name>A0A7W7T523_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031307374" description="Peptidase C51 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="352"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="500" mass="52146" checksum="83F40D44DABA8B51" modified="2021-06-02" version="1">MFRKGLATLAVGAAALAGVSGTAPTASAADPTGDVYVSLSDGGRFVQDSWKWHEFFGIGNEIPLTGDFNGDNRDDVATFTQGTSGDVYVALSTGNGFSGTSVKWHDNFAFGTETPLVGDFNGDNKDDIVTFTRSGTGDVFVALSTGSGFAGTSVKWHDFFSIGNETPLVGDFNGDGKDDIATFTRGDTSDVYVALSTGSGFSPSSVWHNHFGIGGEIVDSGDFNGDGKDDIVTFTRGEAGDVYVSLSDGTKFVQDSWRWHEFFAIRTELPEVGDFNGDGKADIATFTRGAAADVFVASSTGSAFVGTSIKWHDHFATNTEVPRVGDFDGDRKADIATFLLGGTTSLRTAIVDVARGELGVKYPGCLKYGDCARYNWCAYFATWVWDRAGIKGVPRGKGVATDLGSWGAERGLFKRRPAGQVGNPAVGDWVIYGEPGSGMGGHVAIVASVNSNGTISTIDGNAAGGSPTTSKVALSTINPITARAGGNNVLISGYVSPPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T527</accession>
    <name>A0A7W7T527_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamide riboside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="28969" checksum="C92ADE81CB2D95E4" modified="2021-06-02" version="1">MQQKPLRLAISGTYSTGKSTTTEALSVATGIPRTHAKTSREILMDIVPGKQVQELSAMELVKLGLRRFEERVQNESVDGSFISDGSVVHEWVYGEARMRVGINPGASLPLRLVKTVVGAPVRRFYQQYMDVYGQLTKDRAKRLYDAYVHLPVEFDMESDGHRPVSEKFRRLSDDLLLASLEEMGLPYHVVGGSVAERLEKIVALFDLRLVMPLDEAIGIARSRVKAAIDVLHDDDRFHEARRRKSLRTRVAYALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T547</accession>
    <name>A0A7W7T547_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22008" checksum="E516201E557C0105" modified="2021-06-02" version="1">MVGVTMATVLVGGVGNATPVDEFADLDATAALVDDFEATEGLEDTELDEVTLAKAPKFQLPFKCGQVWLGTTYNGHWPSKESARDFWRDGGKTKGQPILAAAGGKVISAKYGSRQGWGVSLNNGDGYRTYYFHMTSKPKVKNGQKVKQGDLLGYVGDTGQAKGNPHMHYSVTKVTGGKEKGIKPYFDGKFHKPGTKAKSKNKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T549</accession>
    <name>A0A7W7T549_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030728513" description="Fibronectin type-III domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="666"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1064" mass="112039" checksum="915CA29C77733BF3" modified="2021-06-02" version="1">MRTTAFRATVVALTAAALAVPVAHADPTAVAEVGAHGWDTYRQLDRLPTLTPPGGQTRQFSSFGRDGSNDHDGFSGRYSCLRTDAQGCVIAEDAGAGEIASMWFTQGTAGRPTGDMTAVGKIRIELDGRTVVDRSLQSLVSGGQGAPFVHPLVTTADQSSGGVQVKVPMPYRTSMKITVERNPNFYHVDYRHFPTADGVVAFNPADRADDVLATLRASGTRDPKPAAAGATTASRTVSLAPGARTTLAQPTGPGAISALRLRGDLSALRLRITFDGKTTVDSPAREFFGAGLGTARTLGSLMFASDPAGWSSSWWPMPYRTGATVELVNTGTAAVSGIGTEVTSAPDARWTTALGPGGDAGYFTTQSKVGATTPGQDWAMVSAAGRGKLVGVTQNVRGATVGRGYLEGDERVHVDSSPSPQWHGTGTEDFYEGGWYFDRGEFGNPFNGNTRHLVARDGCATECDSVYRLMLADSIGYGSALDFGIEHGPQNDVPAEYSTTAYLYARPETATRRTDVLDAGDPASRSAHSWTETGGAQAALESRFEGDEDEVVVRDDVRSSTGQTSFRLAVASTNTGVLLRRLGDQTRAGQRADVLVDGVSVGTWAQPLGNDISRWLDDTYALPSSATAGKSSIAVTLRPVGGAWTAAKYAADSLVPPFLDTAAPSVPTGLAFSGTRAHSLRLNWQPASDDVAVDTYRVLGSTSASGPFTVVGTTASTSFAHKVLRANQNWYYKVVAVDAAGNAGTPSAVATARTAHPLSSDVDGDSRDDIVTFTRGTAADVFAAKSDGSRFVGDAVKWHDRFAIDGEIPVTGDFDGDGRYDVATFTRGAAADVFVSLSDGTKFAQDGWKWHDYFAADAEVPLVGDFDGDGRDDIATFTRGDNADVFVSLSTGRGFAQAGWKWHDHFAVGTERPAVGDVDGDGRDDIVTFTGGAAYVSLSDGTKFVQNAWSWHAALPGRSTLGDVDGDGRDDVVSFVDETVSVALSTGSSFGASTRWHDHFAVGEELPGVGDFDGDGRDDVVTFTRGTTADVYVATSNGSRFVGDGVRWHDGFAVGQEVPRPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T565</accession>
    <name>A0A7W7T565_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="8031" checksum="6F60F51047B53A54" modified="2021-06-02" version="1">MNLDKPWNDVADQLRPAQPDLDTPDDEVLDDLDTEPGTEPIDVIEADPADVADQRWIVPLPDDRVDDQPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B0</accession>
    <name>A0A7W7T5B0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24610" checksum="FA6EAE830349C6D7" modified="2021-06-02" version="1">MKAAEEKREADGQTTISQSFDFSASHELRLLPTSHKCSRNHGHNYTVTVSALVHDDAPGDLSPLGEYLTATFDHRLLNEQVTFHPTSELLAAHLAKWFRDNVEPATSITLVAMVVSETATTSARCDGVTGEVTISKTFTTSHGDVTLVLGADGLDEFGFITDFGDLKPFGAYLQSPAADAGLRAAGPALVAHLAGWFVDNVEPEIRGRLVSVRVDSRATTGLWERGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5D2</accession>
    <name>A0A7W7T5D2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA (Cytosine-5)-methyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9198" checksum="49433BEE1DFE02BD" modified="2021-06-02" version="1">MLPTPRASDTGTAGRKAGAGFRPPLSQQVLPLVDPEAFLPTPRATDGTKGCPAQRGSKGDLMLPSAVIRLLTPPAHHRTDGNETDDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5I4</accession>
    <name>A0A7W7T5I4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="688" mass="74019" checksum="DBD153D285E4E63A" modified="2021-06-02" version="1">MSAGDEERRARAVRGAVITSVHDVLSECDDLTDERVPRVVVRTRVSLDGEAQADIRAAVREVRSTFGDGDGRVRVSFELSADAADPCDVECTVPGVERPEPEAEPEPEVLDASARLLVLGFDGVEFHFLLEPGRDWLPLLRPAAGYDGTGLLLPQALSDVPHGHLVDLSFAGGVLRARRASERPDYAVSVNGTNLVPEGAAIPESGEVLFASLTGSGSRALTYELLAWSDEVPSPGTGADVLDGAPHPTESADPANPGALLVQPPAAGTKSAARRFPLPTGRTDAPVHDLHVQVLYTTATHPGSSDRSHVKIYRCATPQHAAYLRRHLATQAGLVRQANAVAGRPGERTWSVAPIHLVAVTPAPQVLTARADPSSVTTNAENRLSAWFGVPDQPQPDCFVIVASPLLEPVGWAGHEQLGTAPSGGQLSALAALAAGVDHLHFLGVAHCDIKPQNVCHHLDAQGRGVYVLVDGDAITRTGGPVAALRFTPEYASAEVIRAAQRVRAPGREVIDVREHDRFGFVLVVLTALVGIDKVDALLRGAYGKRPVDSISMVEEAVADLWSTRWDRFTEELIRPLRPGTLLDDEWSAKAWLDRLSALWSPEQEQRVVEADRVAVGTYGREVTAIRTGVQDERAPAWAEWRAELVNRIRAHQQLVARRVYRNWLWAGRVAFGVCVLLLVATIAGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J8</accession>
    <name>A0A7W7T5J8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">F4559_004342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4966983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25696" checksum="E11600CAB0E4E6EC" modified="2021-06-02" version="1">MTKPILLVVLSSVIIAGVLLVGTRNLKLVPGRFQFSLEYIYGVARDGIAKEQIGAEYRKYVPFIMALFSFVLVNNIFGIVPLVQFPTMAHIGFPAALALLLVYPTYHWVGIRRHGLRGYLRNQFIVPDVPKPVLWGLLIPTEVILKFFFDPVTLALRVFAAMFAGHLLVAVFALGGEFLLFEAAPLLKPISAVSFAFAVAITLLEAFIQVLQAYIFATLSAHFIGRSLAEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L5</accession>
    <name>A0A7W7T5L5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="111" mass="12381" checksum="5AC470187C8C73CB" modified="2021-06-02" version="1">MRRPGAYHCGLDAAVEVIGGKWKVLILWALGERPHRFGELRRELAGVTEKVLASHLRELEDDGIVHREVFDEVPPRVEYSLTGSGEALVRALEPLGEWGRAHVPGVPVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q9</accession>
    <name>A0A7W7T5Q9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23297" checksum="5EBDDA9C7C96B675" modified="2021-06-02" version="1">MAFSAVTDEHRLGGFWRRLAATERVAVAAVARYRRYRSGARLLSAGEQGGWAAVLHRGRVRIVDDGRVLGTRCAGDIIGEHALVDDGKRPRTVVAHTPIQALVIGREDFNRVVDRHPHVLWVVSSIALERLPDPGTATDDAFTKVVRFLVREAEGARTAAVRFSSQEELARMLAVSRASVVRAMSSLRAAGIVETGKGGVTVRDVAALRARCGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5X4</accession>
    <name>A0A7W7T5X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GT2 family glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="681" mass="76307" checksum="1F923D304EE1E47C" modified="2021-06-02" version="1">MPLAVVVVTFHSADVVADCLRSVAVALESVPDGRVVVVDNASTDDTLDVVRRTAPDARIVARVSNDGFAAGVNAGFAAAPDCDILVLNPDVRLAPDAITLLLAALDQERTGIVVPRLRDADGGHQLSLRRAPTPLRALGEALLGGTRAGRVAALGELVVDPRRYEGAGTTEWATGAAWLISRECREALGTVEERYFLYSEETEYMLRAGREGYAIRYEPRARAVHLGGEQSTSPLLWSMATTNRVRMVRERNGRATALLMWLVVVLNELLRAPRHTKHRRALADLLRWRRWPARPDGPREDGWICFSAQDWWYHNRAHSDFQLMLSMAERRKVLVVNSIGMRMPTRGNSTHVSRRILRKLRSVAKFVRRPHKNFYVMSPLPLPFYGSPLLRKINAVLVRAQVKLVATALGIHLPVIMVTIPTAWDVVQPMRRHRLVFNRSDRHSDFPEADRTAIETLEHRLLENSDHVVYVSHALMDEEAPRTGERAHFLDHGVDVDHFTARPDFDWPDDIRSIDGPRIGFFGALDDFVVDFDLLERVAAELPQASLVLIGDANHPMERFDKYGNVHWLGFRPYDTIPAYGSAFDVAIMPWLDNNWIKHSNPIKLKEYLALGLPVVSTDFAELASYTDRVRATTDHASFVAAIRTTLTSGGLRPAATLRASVLQYSWRSRAAELLTLTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y3</accession>
    <name>A0A7W7T5Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ni,Fe-hydrogenase maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5224" checksum="29337D4763D213EF" modified="2021-06-02" version="1">MIFAVEVADTDVGRGLSQMVRMAVPRVVQAVLDELHDVDTAPSSGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y6</accession>
    <name>A0A7W7T5Y6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="435" mass="44750" checksum="27DADADEDE6A59FB" modified="2021-06-02" version="1">MHAKTGHGHGHGHGPVGPSSAPVRRLLLVLLVPLVLATVVGALVLYPWGHEQKTGADVGLTQTPVLGEVTAVARGGCGPGGQDTGCVLVTVRMTDGAAAGRDVRVPVPDQPTSPTFEVGDEIVLSFAGGDPAESTSYQLADFQRGTPMLVLAVLFAAAVLLLGRRQGLAALGSLVVSLLLIALFVLPAILAGESPVAVAVVGAGLIMFVVLYLTHGISARTTTAVLGTLTSLVLIGVLGVAFSAFSRLTGLDQDSANLIAVLGHGIDARGLLLAGTIIGALGVLDDVTVTQTSAVWELRRANPALGFRELYAAGSRIGRDHLSSVVNTLVMAYAGAALPLLLTFALSGRTLAEILTTQQVAQEVVRTLVGSIGLVAAVPITTALAAWVAGREAVEEPVRKIWTPPPVPESLRPRRLTGDLGTGHDRAQGTRRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B4</accession>
    <name>A0A7W7T6B4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="12">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">APS kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cysC</name>
        <name evidence="14" type="ORF">F4559_004745</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">APS kinase catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="444"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4967386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="607" mass="66424" checksum="851EBF265568077F" modified="2021-06-02" version="1">MGPLLRIATAGSVDDGKSTLIGRLLYDSKAFFVDQLAAIERTSRERGEDVPNLALLTDGLRAEREQGITIDVAHRYFATPRRKFVIADTPGHVQYTRNMVTGASTADVALILVDARKGVLEQSRRHAFIAALLGIPHFVVCVNKMDLVGWSQERYDEIREEFRRFAMRLDVPDLSFVPMSALNGDNVVNRGTEAPWYEGTSLLHHLEEVHVASDHNLIDARLPVQYVIRPHQDFRGYAGTVSGGVFRPGDEVVVLPSGFTTVVERLWGPGGEPVAEAFPPQAVTVELADHVDVSRGDLLCRPNNRPHVGQDVDAMVCWLTERSTLKPGAKYLVKHTSQLVKASVRTLDYRLDVNTLHRDETATGLSLNEIGRISLHTQTPLLFDSYRRNRGTGSFVLVDEATNDTVAAGMITGPRVSSSNVVWHAPTVTREQRPTRGLTVWLTGLSGSGKSTVAAELERRLVASGRPAYLLDGDNLRHDLNADLGFAADDRAENVRRTGAVARLFADAGTVAIVSLISPYQADRDAVRAAHEAAGLEFVEVFVDTPLEICERRDPKGMYARARAGEIRGFTGVDDPYEAPVDPELVLRPADGDPADGAAAVLALLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6C5</accession>
    <name>A0A7W7T6C5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mak_N_cap" evidence="9">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="APH" evidence="8">
        <location>
            <begin position="208"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="45537" checksum="A2B81969DE4E20DC" modified="2021-06-02" version="1">MIPGLADWLPRQRWFPGEDAGEVRVVRAEPFADGGVLAIVDTALGRFHVPVGIRTSADVPAGAVIGTADGLVHFDALADPELVVGLYEAVAAGRPGAVAFRPEPGAELPLPVSVRAMGVEQSNTSVVIGGHSVLKVFRRVWPGENPDVTLHRVLRESPYVPDLLGTFALDGTDTLGLVESFVADAVEGWSAALDDLGHVLAGRSRDLDLVGGLGRLGVAVAGVHGRLGRALGFSRLSPDTTADRFLGRLDDTLAVAPELAPHASALRVLLDERVRSAEPAVAHRVHGDLHLGQVLLSSGQWTLLDFEGEPSASPTERARADSPLRDVAGMLRSFDYVAGHHRLDASTWSADHERRSRDWVRDARRAFLTGYSGHSAVDLKASKALLRAYELDKALYEVRYESANRPEWRTVPLRAVRDLIGPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D3</accession>
    <name>A0A7W7T6D3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21607" checksum="6411455AFF83725E" modified="2021-06-02" version="1">MEKATPSHVKVTRRLAIGVIIVGELILVLGPLLAKPLDWLARQSADWWGAAGQWAGALGSFAAVVVALAIAGSGTREARARERRRQQATATLVRGEFELSGNPYRVALINDSPLPVFDVQIKEVRGWRLPEVRRPFRGWQPTAVLPPGKRVFVEAVVMAGAKEGISEWLGYTVVIEFSTEEYRWRREGDGLPGLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6F2</accession>
    <name>A0A7W7T6F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1193" mass="135090" checksum="ADBA96298692860C" modified="2021-06-02" version="1">MKDLRKQVVALENDLRVRGAEEEFETSLRAEYDQAWEAKRTAATFDAWREDRITQVAAAWVLGTVFVRFCEDNGLIEWPFLAGPGERLADAEERHEAFFRENPRLNDRDWLVAAFDHLSDAHPTVAGLFDKRHNPLWEITPSFEAATALIGFWRRRGDDGGIRHDFTDPEWNTRFLGDLYQNLSEQARKTYALLQTPEFVEEFILDLTLEPAVEEFGLKGLRTIDPTCGSGHFLLGLFRRLLAKWQAKESGTEPWVLIRRSLESVHGCDKNPFAASIARFRLLVAALHAAEATRLDRISADFPINVAVGDSLLHGRGTPGVQVDLFEPVNAHTYRPEDVEEYSTCDLLGISSYHVVVGNPPYITVKDKRENENYRSIYDACSGTYALSVPFAQRFFQLAVRANGSDENSGHVGQITANSFMKREFGKKLIENFFPSIHLTHIIDTSGAFIPGHGTPTTILVGRNHHARMAQPVRGVLGVRGEPSQPEDPSQGLVWSAIVDHVHNPGANSDWISVEEIERGHFGTHPWSLSGGGAGSLQIFLERACSNRLGAKEPTIGFGAVTRADDAYAIGGRSLDRHRIPSRFQRPTVDGESIRDWSTNSLLGFLWPYDTESPTLSARTTPAIERLLWANRATLQARIAYGSNQTERGLEWFEYSMFFWRRYLGPTLSFAFVATHNHFVLDHGSKVFKQSAPMIKLPATATEDDHLALLGVLNSSTACFWLKQVCHDKGSQSGTGGFMHDEWERFYEFTGTKLQEFPLPAALPLEFGQALDGLAQELARLEPSAVADREVPAREILKDAQAEQEHIRARMIALQEELDWQVYGSYGLLTDAEVARLTAPDLDSVPEIKLGERAFEIVLARKVAAGNAETVWFDRHGSTPITEIPDHWPDWYREIVQERIDTITRRRDLALIERPECKRRWSLVPWEKREAEALRDWLLDRCENPDLWYALRDTIKQPRALTVNQLADKLGSDADLVAVAQLYATDHLGKRDLTLAETLERIVADQHVPYLAALRYKDSGLRKRAEWENVWELQREEDRTGRQLDIPVPSKYGSGDFRRASYWSQRGKLDVPKERFVSYPDANPDSDPTLLLGWAGWDHRDQAQAIVNVVNDRVDQSGWDSDRITPLLAGLLELLPWVRQWHGEYDDEWGGIPAEEYSAYLTTKQTTHQLTEDDLRTWRPAAPTRGRRAAGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6H7</accession>
    <name>A0A7W7T6H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="68"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="243" mass="25379" checksum="CD4C0D005E8985E1" modified="2021-06-02" version="1">MTVEREDLVEQVRAHYAAKATTCCGPSDVTVFGVARYADVNPDEVPGQALLASLGCGNPTAVAALGPGDRVLDLGCGAGLDVILSARRVGTTGKVYGLDFLDEMLSRARENVALAGVHNVELLKGTIEAIPLPSDSVDVAISNCVINLSVDKQEVFRELFRVLRAGGRLGVSDVVADDRLSPAERARRGGHADCIAGALSFTEYREGLLQAGFVEPTIEATHPVADGMHGAIVRAVKPAGCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P3</accession>
    <name>A0A7W7T6P3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="13132" checksum="0703FEE5F2EA9D7D" modified="2021-06-02" version="1">MTAPQRAELARRQAELLRALLADGDVPAGFDPDRVAVEARALLSKRRGIVAMLRPDLVDSLGERFRPLFDTYGRGRPRTDGSRMREDAAAFAEWLADRGELPTRTKRRWWQRADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6U8</accession>
    <name>A0A7W7T6U8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="442" mass="49168" checksum="7019CD6E700BE2F8" modified="2021-06-02" version="1">MTEHETTPGTTGGSGAGAVVEETRAEGAAAPAPVPVASDHPDRWGRVDADGTVYVKTADGERAVGSWQAGEPAEGLAHFARRFDDLRTEVELLVTRLSSGAGDPKHASTSAKHVQEQLAEAAVVGDLAALTARVEFVLAKAEEGIEAAKVAKDEARAAASARKLELVEEAEVLANESTQWKAAGDRLRAILDEWKTIRGVDRKTDEQLWRRFSKARDAFNRRRGSHFADLDRQRGVAKARKQELVEEAESLVSSDDWGVTAGRYKDLMVEWKAAGRAPKEADDSLWQRFRAAQDAFFARRSEAFSERDAEFSTNAKLKEELLAEAEHIDPSHDLETARQQLYRIQERWDAIGKVPRERVRELEGKLRSIEEKVRGAVDAQWRRSDPEAEARVAQFRERVEQFEAQAEKARSAGDKRRAEQAEAQAKQWREWLAAAEQAVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I5</accession>
    <name>A0A7W7T7I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21456" checksum="B7B59823E5B7629A" modified="2021-06-02" version="1">MPRISADTLAEHRANRLRTLLDAGRAIVAEEGAEALTLAALARRVGLSRPSLYEYFRSREELVAAIVGDELPEWGRRLAAAVRAADDVPAKIEAYLRTELEIIADGSHSAVVALSAHALPEASRDLIRTEHGKLLEPLVDVLAQADVPRPGLRALLVHGAVEAAARTLRPGDAAQYEEVVAALLDQVLHGLGGGRPDQPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7R3</accession>
    <name>A0A7W7T7R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8833" checksum="A94BFA258B378CD6" modified="2021-06-02" version="1">MGSLDVHYLYEHGDTPGTVSTVDEVDALIDRVRAESPPAAPILMEVHRSGDPYAQGLDVGIEVDRGASHLCAMAGCPVGKGCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z4</accession>
    <name>A0A7W7T7Z4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ParB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040851">
        <property type="entry name" value="ParB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18064">
        <property type="entry name" value="ParB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB_C" evidence="1">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12102" checksum="2F574102ACBECDB6" modified="2021-06-02" version="1">MAQSPEAAPEPVSAVNEITVAVTVSGEDQATGEASAGGRRVQRTVNFDQDVLDRARAAATYLAAYEPTAGVRSLADIVNPAVAAYVAELERRFNGGEGFRPVFRMPPGRPSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T828</accession>
    <name>A0A7W7T828_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31285" checksum="77FCAC3B66A39ADF" modified="2021-06-02" version="1">MGNLDGKAVVITGAGRGLGEAYAMHAAQAGASVVVNDVDGDLAERVAEHIRAYGGQAVASAHTVADPAQAEKIVATCVAEFGRIDGLVNNAGLNYEAVPWADDPEQIRTTVEVNLLGVIYTGMAAMRAMRDQGGGGSIVNVSSGAFFGQRKLGTYSATKGAVASLSLSWALDLESDGIRVNAVCPVAHTRMVWQSERSLRAIPADRTPGKVAPLVLFLLSDAAEGITGQIVRCNGRQLHLIGQPYFKQPVLESDAWDAVSVKRAFDGVLQAHLEPFGLEKRMPPRLRELVEPSQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T838</accession>
    <name>A0A7W7T838_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="281" mass="30262" checksum="64F4045E16DA8E06" modified="2021-06-02" version="1">MAGIGGAQTPARKARWTVLNVLVVAYALFPVLWIVSLSFKTTATMGDGNFIPREWTLDNYSSIFGTAEFVRALVNSIGIALIATAIAVVFGTMAAYAIARLDFPGKRALVGVSLLVSMFPQISLVSPLFEIERTLGLFDTWPGLILPYITFALPLAIYTLSAFFREIPWELEKAAKMDGATPGQAFRRVIAPLAAPGVFTTAILVFIFCWNDFLFAISLTSTESSRTVPVALSFFTGSSQFEDPTGSIAAAAVVITIPIVLFVLFFQRRIVAGLTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T862</accession>
    <name>A0A7W7T862_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S1-C subfamily serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="310"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="44193" checksum="5E672F3F91FF3002" modified="2021-06-02" version="1">MTTAFGRPDTTTRLQRPPLDASGEPEVEPVFWEGEPAGDAWRDPGASAVIGPPAVSEKAAEDGEAAQVGRGPLLSVPELLFGRRVKPTALALLLVVALAVGAAGGVVGWLFGRAGNELTDAGVTLAEVKPGKERPVGSVADIAKRVTPSVVSIEFKGANVAGVGSGVVIDGAGYILTNDHVVAPAVQDSSAKLTVVFIDGKRAIARVVGRDSKTDLAVIKVEADNPTVLQFGDSDELAVGDTVLAIGSPLSLSNTVTEGIVSALHRPVTAAGENGGPQVTYDAIQTDAAINPGNSGGALVDSSGALVGINSSIRTETGGSVGLGFAISGNYARKISQDLIQKGEVKHADMNVNVRSASAETAEGAQVQNVPDGGAAAQAGIVEGDVIVKVGDRLVRNAAELTVAVRDHEIGETVPVTLARQGRELTVQVTLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T899</accession>
    <name>A0A7W7T899_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron complex transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030551512" evidence="1">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="33433" checksum="D484DB0BE5617A05" modified="2021-06-02" version="1">MRIAAIVAGAALLLTACGTTEDTTTPTGAAGDAPVTVTDSRGKEVRLDAPAKRVVALEWAEAEMVVSLGVTPVGVADTKGYRTWDTAAPLGDEVEDVGKRNEPSVDSIVALDPDVVVMAAGREATLAPRLEKYVPVVVTKASDASRNLDRLREDFTLVAKTLGKTAEADRILSEMDGKLDGATTALKAKAGTPFLMADGWLKGSTVDIRPFGKGSLVSDIAERLGLRNAWTGQVDARWGLGQTDVEGLTAVTDPATVLFYSASEDDVFTTGLAQNPVWQRLPFVSSGKVYKFKPGTWTFGGPRSAVAVADQIVAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8B1</accession>
    <name>A0A7W7T8B1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine-binding chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15748" checksum="7380B58C10C84D30" modified="2021-06-02" version="1">MSTVQYATFEVADRLFGLEVERVQEVLSFSEYTPVPLAPGYVGGLFNLRGQVIAALDMRVRLGLPPTDLSAGAMNVIIRTEDESVSLLVDHIGDVVELDDRHAEPLPDTLMGPVRSLITATFPLTDRLMLVLDAERAVDSANHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8F6</accession>
    <name>A0A7W7T8F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.16" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="35339" checksum="AE93852B631F735A" modified="2021-06-02" version="1">MLDRLDVPVIAAPMAGGASTPALVAAVTEAGGFGFLPAGYLSVEAVAALLTETAALTAKPFGLNLFVPGSRSTTDLHGYRDRVRDATGVEPGEPRWDDDAYAAKVELAIAMRVPVVSFTFGLPEAGDVRRLHAAKSAVVVTVTTPAEAVQAARVGADALCVQGGEAGGHRGTFVDDGVSPGGGELYGVLAALRLVQARVDLPLIAAGGLVHGADVAAVITGGAVAAQLGTAFLNCPEAGTSSAHREALAAGARRTALTRAFSGRPARGLVNRFLTDHSAAAPAAYPQVHHLTKPVRATGDPELMSLWAGQTYPLGRSLPAAEVVRRLEAEARQAISGAARRFPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8L0</accession>
    <name>A0A7W7T8L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="26293" checksum="B2F6610C6C688E4F" modified="2021-06-02" version="1">MANDGLARPVALVSGGARGIGRAVVVRLAQAGYDVAFCYRRDVSAAELTIKEAGLHGGRVIAEQVDVADKAQVDEYVERTVAELGVPSALVSCAGVVRDKPLALLTTDDWNDVLRTNLDGAFHLCRAALRPMIGLRGGSIITVSSIAGVEGNATQTNYSASKAGLIGFTKALSKEVGRYRIRANVVAPGLIDTDMTAGLDEKTIKGYLQRVPLNRFGKSAEVADTIAFLASEQASYITGQVFRVDGGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N2</accession>
    <name>A0A7W7T8N2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein YeiH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="90"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="20634" checksum="15311663E090532A" modified="2021-06-02" version="1">MLTALELIGIAVFAASGALAAVRARLDVFGVIVLALTTALGGGLTRDVLLGVHPPTALVTWPYLAVAGGTGLVVFWYHPTVAKLRRSVLLLDAIGLGLFVTAGTTTALLLGTPEYTACLIGVVTGIGGGVLRDVLLREIPLVLRQEIYAVAALGGALVVVLGHVAGLPAGPVSILASALIAGVRLLALWRRWNAPTAPKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8U4</accession>
    <name>A0A7W7T8U4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="6022" checksum="2A1E58512C899DDC" modified="2021-06-02" version="1">MVLWRKSSRSNSSANCVEVACSGRRVLARDSKNPAPELAFPAEAWRRFLDKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9M9</accession>
    <name>A0A7W7T9M9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_38 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_38" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17740" checksum="30E23ACC091F7C83" modified="2021-06-02" version="1">MPRNLITDADRTRVRELHAEGKTRNDIARAINRSPSTVTGIARTLGLSFDRSKTAAATQARQIDNRSRRTQIVGRLYGRAEHLLARLEAERYVFTATTIHGIESKPLDHVPAPDEKALATALSTHLSAASRLEQVDADKGSEGAKSMLGGLAVALGIQTRFGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q4</accession>
    <name>A0A7W7T9Q4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylglucosamine acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="24489" checksum="01A79E3B11361073" modified="2021-06-02" version="1">MANRIHPTAIIGDGVELGDDNVIGPYSVIVGPCRIGNGNWIGPHVTIGTPAEDRGGPHPVAWEGELEGHGVVVGDRNKIREYVTVHQGTHRPSAVGDDCYLLVRSHVGHDVTLGDNVVLACSAQLGGHTEVWSHTNIGMSTVVHQHGRIGPGAMVGMGSAVRKEVDAFTVTVGNPARATGLNVVGLSRRGCDEQTIAALEPFLKGKGDLPADGLPEELSTLLKAWADRAPLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W7</accession>
    <name>A0A7W7T9W7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16334" checksum="C671C59CE11CA33D" modified="2021-06-02" version="1">MLTNGEDPRPVKGAVREVHSAARAARLEYSPDLDGLADPGEVVWAWVPYEEDPSRGKDRPLLVVGRHRRALLALMLTSRDPDPYEADDFLDLGSGAWDRGGRRSYLRLDRVFELAEDDIRREGSVLGADRFGRVAEALRGRHGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA24</accession>
    <name>A0A7W7TA24_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
            <shortName evidence="1">AKB ligase</shortName>
            <ecNumber evidence="1">2.3.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kbl</name>
        <name evidence="4" type="ORF">F4559_006688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + glycine = (2S)-2-amino-3-oxobutanoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:20736"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="2.3.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="1">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00985">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011282">
        <property type="entry name" value="2am3keto_CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01822">
        <property type="entry name" value="2am3keto_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="43"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="1">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding; shared with dimeric partner" evidence="1">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="392" mass="42488" checksum="B6A1900AFC7F48F9" modified="2021-06-02" version="1">MYGALRDHLRASLDEIRDAGLYKAERVIGTPQNAAVRVGSGDEVLNFCANNYLGLADHPKLIDAAKDALDRWGFGMASVRFICGTQEPHKELEAALSRFLGTDDTILYGSCFDANGGLFETLLGPEDAVISDELNHASIIDGVRLCKARRYRYRNRDLEDLEKQLEAAADARYRLIATDGVFSMDGYLAPLDGICELAEKYDALVMVDDSHAAGFIGPTGRGTPELFGVRDRVDVVTGTLGKALGGASGGYTSGRREIVEMLRQRSRPYLFSNSLAPSITAASIAALDLLSSSGALLTRLRDNTRLFRERMTAEGFDLLPGEHPIIPVMIGDAAVASRLADLLLEQGVYVIGFSYPVVPHGKARIRTQLSAAHSADDVHRAVDAFVAARSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAS3</accession>
    <name>A0A7W7TAS3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chemotaxis protein MotA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="100"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27052" checksum="DD2F59C709537A36" modified="2021-06-02" version="1">MDPASIAGIVLALVAIIVSMLMEGGDPMSILLLPPIILVIGGTFGVAMAGGMMSDSMGIGALFKRALMTKKIENGPLVDVIVKLSDRARREGLLALEEEAKSVEDPFLRRGLELAIDGTDSREVREILEGEIDSKRRADKAGAKIFTDMGGFAPTIGIIGTVLGLVHVLENLSDPSSLGHLIAGAFVATLFGVMTANVFWLPLANRLKRISELEIEGMELALEGVLSIQAGANPRIVARKLRGLVSTGGEKQQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBG1</accession>
    <name>A0A7W7TBG1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF)-like protein/PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="276"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="419"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="676" mass="75676" checksum="61E6E5B26263D365" modified="2021-06-02" version="1">MTRTEVAEHLRSLTEVLVHALHASPFRTAPGYEIGARLVEAHFTGTDTLGRTVQLLGDDLLSELGIPQDELMRSRLAALQGALSAGYARALRERTLAEQEAIRAAVLDARDQAEAALRASEARFRAMFTDAAIGIGIADIEGRILDVNQALQEMLGFGVEEMRQYNIRDLMHPEDGTAVWRLYDQLTAGELDHYRAEKRFRRADGEQVWTHLTLSLVRDDHGEPQYQVAMIEDVTERHLLQNRLRYQALHDPLTGLPNRALFLERLSRVFHNGESARAGLCYLDLDGFKVINDSLGHDVGDQLLVEVGRRLDHSVSGPGKLVARMGGDEFVILVEGSRDTRDIVDVADRVLRELESPIRIAGHELTVSASIGIVERELPGTTAADLMRDADITLYWAKADGKSRWALYDPERNAREVARFTLSATMPAALERDEFYVDYQPLVRLEDSVVVGVEALVRWQHPEFGRLAPDRFIELAEETGLIVPLGRWVLRRACEQAKRWREEFGEAAPFVSVNLAVRQSRDPELVRDVKRILDECVLPPNQLQLELTESAIMGTADEPLEALRVLSDMGVRIAIDDFGTGYSNLAYLKHLPVHELKIAGSFMEGLRAEDEEDAVDMAIVSTLVRLAHALELGVTAEGVETPAQAKRLHRLGCDTGQGWFFAKPMKPHEIDELLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBY2</accession>
    <name>A0A7W7TBY2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="203"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="410" mass="46658" checksum="DD218B2A200B0C15" modified="2021-06-02" version="1">MAAKKRDNGEGSIYPHRNGFAAYAWVTTPVGKRTRKYVYGKTRDEVHDKWIKLLAQAKEHPIPTSTPKLGTFLRYWLEEVIKPNAAPLTHATNETFVRLHLVPALGDLRLPKLTVSRTQRWMNELARTCQCCFQGKDARRDAKRQRCCARGACCKALLSRRSLSDIRACLRNALSQAIREELVTRNVAALIKIPKVVGQRRARKRKRWTNAEAKAFLASAREDGDPLYAVYVLVVLLAMRKGEALGVPVDAPNFRTEELEVDHQLQRVGRQLLHRETKTEASEDTLPLPPMAAVALKQRAERRKQDRVRAGDEWQETGLLFTTRFGGPIEPRNLNRSWNARCVKAGVPRITVHDGRRSCGSLLVELDVHPRVIMRILRHAQMEVTMEIYSEVSTEVARQALRKLNDSLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCR6</accession>
    <name>A0A7W7TCR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="218" mass="23562" checksum="9AA115C3411892CF" modified="2021-06-02" version="1">MIRVLLVDDQELMRMGFRMVLGAQDDIDVVGEAGDGLDAVHLADSLRPDVVLMDVRMPVLDGVEATKRITEAGTARVLVMTTFDMDEYALSALRNGASGFLLKDTPPGDLVSALRAVASGDAVVSPSVTKRLLSRFLGDHGGELRDASVLDVLTEREREVLVLIAKGLSNTEIARKLFLSEATVKTHVGRILAKLELRDRVQAVVLAYETGLVRPGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTB1</accession>
    <name>A0A7W7WTB1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061810">
        <property type="term" value="F:NAD glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036170">
        <property type="entry name" value="Prob_YezG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160424">
        <property type="entry name" value="SSF160424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="1348"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1442" mass="156652" checksum="3E87ED6F1F4FEC46" modified="2021-06-02" version="1">MSEPKPLNPTEQDALVKQIGLTLMRAAPADWAHVTAEYRATGRYFELSAEVRAADGVVRAWTPPQEVAGLFARLRTGMYRQGRGSWSNARYRLDHPSSYNLDFDRAEPSWQNPPPPQAYVDEMRFFPRTDENVPEWLRHRLSSVPRGHRTARVFDGAGPGGRPSVNRPVVPEPERERLLAYLDGAPVIVAGRGYDADVLADGNPSVVPVAFQTDGQWIWPAAVGYYLRTYGIPPEAELVERARSADFVPPEVSEEARVAAAAHLGAPVAARDTPLPRPPAASVDPGEEVTRSLGEFVPQRIEFDQDGPPYRVTFAEDGTVVDERYRRESYVDGMDLFAPAQYDQDAGDTQAWDPFADDTATPAEQPPADPVPFAETAAFEVGRDYADPVPHDERRVNGHDPLTHTAPFDPLADDEDELADVPTTSAPTEFFEAPAGPDHADEGRSFDDHPDSTPGGADRPPLPEADHPHGFDPRADQGPFDEPAGADTGRVDGVEQHAAFDDHGDQAHGFTDHAAFDDPAADRGRFDGPPTTERAHGFDGPTEAGQALGFADHTTPDRNDGFDRDHGFDRAAGSEAHRADGFQDRPEPGSGFTDHPAPDADRPHGFDTDHGSGTAFDGRPVADGFEVRPESGEDDGFGDPENAHGFDDRDRRYTTDESPVDETGRFDDHPADADHGHPAHPGGFEDHLVSRAEQARRFEEHLEAQAARFDDHPESTVEQTAPIDDRRRFADPDHVPTFADDETGPFDQIRPDSPDPRTHPEQADDRRRPQPFEQHHAEAHPRVFDEPGFASRTDFGHQAPDHDARTPEGTDPTHRTRPDHFAESDHHPTFAPADTTPESGHDTPPDHAAPDHYAAPGHLADPDHRMRPDHGLTADHLAAPADPGRTPDQAPPAYGSDQGLRSRDTGQDPHGQDSGQDPHRHATAQNGRVQHDSGTATPDLHGPGPDQTQVDLSVPPAFRSRSGRGQGTDARVQDGPGIGPDPHRQHGLDTPPSHFTHAGPDRPAQSGHDAPPAHFAQTGPDHPARSGHGVDHLGQAGHRTGPEYQAGQGIGSDHAATHHTGSHPAVDTPPGPDPVVADHLGANSFGVDQAGPTAVGADHTDTDPVVQAAPRDGRPQSDHTTPRPGIPAAPAVPMPAAAPSIPGQSDRRPATDQGRPDTPTAPEPEQARQNQAEEPAEPRQVTPEEEREIAGLRRALDDLGVPHAAYRIGGDPVDRTWLLRVAGRSWEVCRVEAGQVDPVRFDRVEDAASYLIGRLVLAGRRLPRPQYAPQRPPNGFRESRPMPPRPAEQPQQQPVQQQPVQQQTVQVPPPVPQQAQVADNKPAVRTWPINPLTGEPPLTLFRQKKMVELAAGTEIDRFGDGAGNLVYAAGTPFEERSLVPSWISRPYRVYRLRRQVEVLTGVAVPWFEQPGGGTAYLMPKSIDDMLADGILVEVANQEAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU59</accession>
    <name>A0A7W7WU59_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ORF">F4559_001309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="108"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4963950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="32266" checksum="4C2F2EDECBDC275F" modified="2021-06-02" version="1">MAAVVDDFERHLALERALSPHTVRAYLGDVVALLVHLAAGTAADATVESIDLAGLRSWLGAQHAAGAERTTLARRTAAARTFTAWATRTGILTEDPGLRLVAPKAHRTLPAVLRADQAEAAMSAAELGAREGDPVALRDQAVVELLYATGVRVAELCGLDLDDVDYSQRVIRVLGKGSRERVVPFGVPAERAVRRWVEQGRTTLVGDRSHRALFLGARGGRLDTRTARRVVHDVVGAVPGAVDTGPHGLRHSAATHLLEGGADLRTVQELLGHATLATTQLYTHVTVERLKAIHDRTHPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG5</accession>
    <name>A0A7W7WUG5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monoamine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Amino_oxidase" evidence="2">
        <location>
            <begin position="523"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="692" mass="77281" checksum="44FB5B424E8A7CB8" modified="2021-06-02" version="1">MTESRDENRHARWRTCRQLARHLLLVGSDDSDEKLRQLDVLLGAGLDPTDRPKDVLVVGAGIAGLVAAGLLVDAGHRVTVLEANGNRVGGRIKTFHTADPGHPAFRDPLQYGEAGAMRLPDFHPLVLGLVDKLGLGRRLFYNVDVDPATEPPSVEPPPVFYRSFTGQTWPADGQPPVVAQPVKRNRAWIRANGTQVRRADYARDPSMLNEGFHLTADEVRVTTTRMLDDALEQVRDYYSEIVDGVRVNKPFEEWLDGWARVIRDFDGCSMGDFLRDHAGLSDEAIEAIGTVENMTSRLHLSFFHSFLGRSDINPNVTYWEIPGGSRRLPDALHERLVDQVRLGHRAVRIEYWDPRRDHAPSRHVGPDGPFVAVHTVAESDQTGPPTVWTGDVAIVTVPLSGLRFVEVHPPMSYKKRRAVIETHYDQATKVLLEFSKRWWEFTEEDWRRELGAIDGGVHEFYQRVDEAAESAAFSVPQRWETTTTGLLGAHPSVDETAIPDRQLEFNRSVRLIGPAVRPATNVFGGGSATDNPNRFMYYPSHRVPGSEGGVVLASYSWSDDAARWDSLDDDERYIYALRNLQAVHGRRIEVFYTGAGRTQSWLRDPYAYGEAAVYTPHQMTSFHLDVGKPEGPLYFAGEHVSLKHAWIEGALETAIQAAIAVHEAPLELSGPEVLPTRRTPEGTPEHAGSPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL4</accession>
    <name>A0A7W7WUL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13793" checksum="3ADE2EBCA3BD9930" modified="2021-06-02" version="1">MTAQARTASGTEFGEEAAQDAEVRVHLRDSRTALRWRLGCSRLRTRTTPVRGSEDHTTASGVFQRRIHRLDPDSRTIRHQGLIFHLSACGAVAIATDHSVPEWEWCPTCWPTDPSLRDGTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN0</accession>
    <name>A0A7W7WUN0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="28698" checksum="638005AB2623EF6E" modified="2021-06-02" version="1">MEQASWVPSSVDLDRPSAARMYDYYLGGSHNFAVDREAAQAVEKIYPGMAGAARANRSFLRRAVRYLLAQGIDQFLDLGSGIPTVGNVHEIAQAANPEARVVYADLEPVAVAHGSALLADNPRAISVQGDLRDPDSVLSSDEVRALLDFDRPIGVLMVAVLHFVPDSDRPHEAIARFRDALAPGGYIAISHGSADGVPQDGLEDTDRVKAIYRRTDSPLVLRSGTEIASLFDGLDVVEPGVVRLSEWRPDSDDAYISAYVGVGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU5</accession>
    <name>A0A7W7WUU5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28536" checksum="A5692B52D537D588" modified="2021-06-02" version="1">MTLGHAAQRAGLSKGVMSKLENGLRFIRSDEVRALCTLYGVPSDVQEQLVKEASDESSAHLEKSLPGVPKESNTLASYEGDACRMTSWQPLLVPGLLQTFRYTEAFMAADGIPADEIEARAVARLRRQEVLKSRVRYTAYIGEFALGVPVGGPAVMAQQLRELIIAGQRPNVTIRVVPSDAVHSGLLGQWLLLEFPHARPVAHVEQLRSALFLAGPDAQPYADAAARLVDVSMNATDSVRIIEQMAETMEGRAGGGTATVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU7</accession>
    <name>A0A7W7WUU7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein (DUF485 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15305" checksum="93B62F57D7662182" modified="2021-06-02" version="1">MTKAILPPTESRHARSGGRAFATFDEPAAPLLVDAEGNPDFAAIRDSDDFRELRRRILIFVLPATCGFLAWYLGYVVLSAYAPDFMGAELFGSVNVGITFGLLQFVTTITLTVAYSRYSRNRLDPQVDAVRALTSEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV5</accession>
    <name>A0A7W7WUV5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15210" checksum="7B4897D1A0A00817" modified="2021-06-02" version="1">MESVLPWIPPAIRRLLLADPLFAAAVPGGRVSTRAPGDVTTPFVTIQLPTPLGAMGGGGYKPLVQVDAWSATVGGDDPEGVVWRIAMTAKNTLERARNVPYQSMHYSCRVLDAGPLPPDTSRGTSSPLYRAMVRVEMTVHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV68</accession>
    <name>A0A7W7WV68_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">F4559_001981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16150" checksum="DF51F044DA03A7A3" modified="2021-06-02" version="1">MSGEGRPEAVVPDASGLSLGVVATKWHAAITDTLLARALEAAGKASARVTVARVAGAVELPVVAQELARTHDAVVALGVVIRGGTPHFEYVCDAVTAGLTRVALDTSTPVGNGVLTCDTEEQADARAGFPHSVEDKGFEAVVAALDAAVTLRVLRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ1</accession>
    <name>A0A7W7WVQ1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="163"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="31593" checksum="F1E18E2C6D75C41C" modified="2021-06-02" version="1">MVDYHRGERAVQDRAGLAEVAGRSGRSIRTAVPDVAAAFLAGQPVLFLGAEDGAGRLWTTMLAGEPGFLGVPDPHTVTVAARPVDVDPLGAALAGVARVGMIAIEPSSRRRMRVNGVSRPDGDGLVVAVEEVVANCPKYIQRRDPVAGGPGTARVVARGTALDGRWRERVTAADTFFVTTAAEDGRADTSHRGGGPGFVRVLSPTVLEWPDYVGNAMFLTLGNLAVRPDAGLLFPDWVEGAALHLSGTAVTDWSPEAAARHPGARRVVRFTVSDVVEVGGHSPYRWSAPEYSRFNPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVQ6</accession>
    <name>A0A7W7WVQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="479" mass="49893" checksum="B00D396D4889E9D8" modified="2021-06-02" version="1">MDHSESRDDTALARDVLGVPGVVFLVLAAVAPLTGIVVIAAIGIALGNGGGMVVAFVAATVVLLLFAVGYAQMSKSLTNAGGFYAFVVRGLGRTFGLVAGFVAMLGYNCFVAGAIGTSGFFTSTGIAEVFGPDLDWAVWSALSVVLVFLLGRRGLDVSAKVLAVCLVLEVSILLVLDFSVLFRHGFSWSVFAPTIVMQGAGGLALLFAANAFIGFEATALFGEEAKDPHRTIPRATYLAIGFIGIFAAFTTWAVVSAIGVAQAQDVALAHLPTGDLVFTVAREYLGDTLTKVMTMLLIVSLFAALLALHNSATRYLYALGRVGVLPRALGRTHAGTGVPRRAAIVQLLFASLVALAFRLAGLDPVTALTASMTGLGTLGILVLQFLAAVAIVVHFRRVGDGRVVRTVVAPGLGALGLAVIVGLAVTNFSTLAGSDNPVIARLPWLLPLVAAAGLVMAFWLRRHRPSVFESLSTDLERVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU0</accession>
    <name>A0A7W7WVU0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7268" checksum="CC8FF5184E8BC7A3" modified="2021-06-02" version="1">MYVQDGVRMSSYIKIFADASVVVKPSGDEVELGYNGELDLVFTRGAAERLHGALADYLVRDGGSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW8</accession>
    <name>A0A7W7WVW8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="37969" checksum="EF68369F02E7E695" modified="2021-06-02" version="1">MEYRPLGRTGIKVSKLTIGAQNFGVTGTTDHDEAARLLGAALDAGINTIDTADIYGESESVIGDYLSRSGRRDEVVLATKFGTKGLTADPNGKGGSRRWVLRCVERSLRRLNTDHIDLFQLHRFDKHTDFEETLSVLTDLVRAGKVLAVGVSTFPPELIVESQWVSEKRGLVRFRSEQPPYSIFARGVEGHLLPTCQRYGMGVLTWGSLNGGWLSGGYRAGRPFPAGSRAAKSGIDPADPGVLRKLDLVEKLADLAKSAGLTMVQLALGFVTEHPAVSSAIVGLRDRAQLDEALAAADIRLGPDVLERIDEIVAPGTYVDEGQGSAMSSNRGDSGFTAEPFRNPGQRRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY1</accession>
    <name>A0A7W7WVY1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030508563" description="DUF6286 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="3">
        <location>
            <begin position="68"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19456" checksum="A1AFF23923A6011D" modified="2021-06-02" version="1">MKRFSRRSVPAVLVALVVLAACVVVTVVAVRQILGLTPWIDTHAVFRALHGTRWTDPVVVFAAAACVVLGVVLLLCALLPGEPTVLPLRDDDPDTDRAVDSGVTRRSLRRVLRTAASSVDGVTAARLVLTRRAIIATVTTDRTSTTGLADAVRVAVGKRLDGLGPMTRPPLDVRVRDRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV5</accession>
    <name>A0A7W7WWV5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SET family sugar efflux transporter-like MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Set transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004750">
        <property type="entry name" value="Sugar_efflux"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23535:SF2">
        <property type="entry name" value="PTHR23535:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="9">
        <location>
            <begin position="211"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4965988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="388" mass="40430" checksum="0E1DD4532AA24C0F" modified="2021-06-02" version="1">MSAPTVVPARSGRFAPLLAVSFLIGTGYALAMPFLSLFLVRELDSGPVEVGAFLLSTAVVSLVVGTVVGHWSDRRPARRLLLGTATLVGAVGYVLYAVLRNYWGLLAVQLTLISFSGVVLPQIYAYAREMLLGSPRAPLATSTVRMMVSVAWVGGPPLAALLIQTVGFDGLYLAGAAVYLASSLVVWTMLPEPRPIVVTTPADEGGGGRRELYFAMAAMVLLQAGTGVTSSAMPLFVTEDLHGSTSDVGLVFGVCAALEIPLMVGLGALAMRFKPRTIVLVGGAFALAYHAVGLGATSMWQIIAAQALHAVMISAVMGVGISYFQDLVPDRPGYASTMVASSFKISAMVGGPLFAVAQQLGYRSSFGMGLGMATVGLVLLMAGAKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX45</accession>
    <name>A0A7W7WX45_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031512600" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18804" checksum="EE6E61D29E23E3E4" modified="2021-06-02" version="1">MVKTVRRLATALAATVLVLGFTPAVSEATPAYASRIVSRHSGKCMEVDHGSLDSGRRVLQWHCHGGQHQLWRAVDMKTGYVQLRVEHSDKCLEVDHGYLHAGAAVLQWDCHGGTHQQWQQIPLGDGSYAYRARHSGRCLEIEGAGLDAGAWLLQWECHYHQHQRWAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX51</accession>
    <name>A0A7W7WX51_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="125"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="299" mass="32800" checksum="77C6D73BAAB55352" modified="2021-06-02" version="1">MNRFQFVDDHQRHHGVKRLCHVIGVARSSYHHWKATAPYRAARAADDVRLAARIRVIHRESAGTYGVPRITAELHDTGQVVNHKRVARVMREVGPAGVRLRRRHRTTLADPTTAKAPDLLGRDFAAQTPNTRHVGDITYLPIVDGTFLYLATVMDLCSRRLVGWAVADHMRTDLVVGALHAAERTRGSLAGAIFHGDHGAQYGAGSFVDACREAGVTRSMGAVGSSADNAAAESLNASFKRETLQGAQSWGTAMEARLAVFGWAHRYNTRRRHSHLGRTSPIDYENSLLPTPATLTHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF0</accession>
    <name>A0A7W7WXF0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031595041" description="Carboxylic ester hydrolase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="COesterase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="495" mass="51929" checksum="B2FA6AFDF96426A9" modified="2021-06-02" version="1">MRLLLVLAILTATVAPARPGPEVTTDGGTVRGSRTGQVESYRGIPYAQAPVGALRWHPPLPARPWSGVRDATASGSPCAQTILPTGSAEDCLYLDVTTPRGTGRPVLVWLHGGGNTMGSGADIDPARLAARGVVVVTINYRLGVFGFFGHPGLAGSGTFGLQDQQAALRWVRANAAAFGGDPRVVTLAGQSAGAVDVCGQLTSPGAAGLFHRVIMQSGSCRTGQPTYGADGEVRVGVGGFWAPVADRERSGAAVAAELGCGDVDCLRGRSTEELLRHEAGFGPAYGTPTLPENPVTAVAAGRVHRVPVLSGNTRDEARLTTMYAELPLGRTLTAQEYAEALRVAFGADRAAAVLREYPAGADAGAALSALDTDRVFACPQLRTGRDLARFTPVHAYEFADPDAPTSSMYFGQRPAGASHGSELAYVFDLRVGPYAGLTPTSLTPRQRALSDTMIDNWAGFVRTGTVPWRSVRSYAPDRIGSVDGWTAHRCSFWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG5</accession>
    <name>A0A7W7WXG5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="10"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="482" mass="49446" checksum="DEC4131CE7A22A07" modified="2021-06-02" version="1">MSTQERKRPPLLLLCLAQFMLTLDFAIVNVALPWIKTDLSFTSGALPWVVGAYALFYGGFLLLGGRVGDIIGRKRMFVWGLAIFTAASVLGGVATTPIVLIISRALQGLSAAAVAPAVLAMIGAGYPEGPERAKAMGVFGAVSSVGFAGGVLAGGVLTEVFGWRAVMLVNIPVGIYMVVRAAIRLDDDRSRTRKVKIDIPGAILVTASMCSLAYALTLASDLGWGDSSVLTPLIGGGVLLLVFLFVQTKVSAPLVPLSVFRNRGVTGGNLVAFLSGGVMSISTFFVTLYLQHVLGFSAIITGLAFFPQALVVVLASLPVAKATAKHGARPLLTFGALFLIAGSAYLALAPTDGGFLVNVLPGGVLLGLGITVMMISTAVAATSGVPVQHMGLASGLYNSNRQLGVGLCLSVAVTVATLTSGAGAGISVEGIQAAFWLSAALAVLVAVISAIVVPAKKNLPVPPQAPAPRQERDTKLSPVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH0</accession>
    <name>A0A7W7WXH0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="25467" checksum="80071FC4DF01A0C6" modified="2021-06-02" version="1">MSDADARLAARLAREAGDLLLKIRESGGDDLMRRGDAESNAFLLAELAACRPDDAVLSEEAADDPARLGASRVWIVDPLDGTREYGRPGRVDWAVHVALWQRGRGIMAAAVAVPGLNLVHASDDVVRKSAPAPAVPRILVSDSRPPSFAAAVADDLGAVLTPMGSAGAKATAVLRGEAEAFVHAGGQWEWDSAAPVGVALAAGLHASRVDGSPLVYNRPHPYLPDLLICRADAAPRVLAAIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXR4</accession>
    <name>A0A7W7WXR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="36280" checksum="A6EF13D5C3C80260" modified="2021-06-02" version="1">MKAMVFRGPNRRSWEDVPDPVVVAPTDAVVRVTAATICGTDLHILNGDVPEVEPGRVLGHEAVGVVESVGAAVTSIKPGDRVLVSCISGCGRCEYCRTGASGQCRGGGGWLLGHLVDGTHAEYVRVPFADFSTHRLPDEVTDGDAVMLSDILPTAYEVGVLNGRVRPGQAVVVVGAGPIGLAAIETARLFSPGLIVAVDLAKPRLEAAKRFGADVTVHADEDVDDLVADLTGGLGADLAIEAVGVPETFELCARLIRPGGRVANVGVHGRPATLHLERLWIRNATITTGLVDTYSTPMLLRMLAAGRLEATGFATHHFALDEMDLAYDVFTRAGETGALKVVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX4</accession>
    <name>A0A7W7WXX4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic divalent cation tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13773" checksum="1D5519310A672297" modified="2021-06-02" version="1">MSGQLATLGSAIRSERDDVTDEHVVVISTTDSAESAAELAKAIVDARLAACVQVSSPIRSVYRWDGVVQDDQEWQLWIKSARDRLDELTAFIKANHSYDTPEVVALPIVGGNPDYLKWITDETRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY2</accession>
    <name>A0A7W7WXY2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="643"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="783" mass="85190" checksum="B47B36E86F84579C" modified="2021-06-02" version="1">MTTAIHQRIAGELGVRDGQVAAAVDLLDGGATVPFIARYRKEATGALDDAQLRTLEERLGYLRELEDRRAAVLESIRSQGKLDDALEASILAADSKARLEDLYLPYKPKRRTKAQIAREQGLEPLADALLADPSLNPQDAAAAYVTEEVADVAAALQGARAILVERFGEDGDLIGDLRERMWTQGRVASKVREGKEEDGAKFSDYFDFSEPFTKLPSHRILALLRGEKEEVLDLQFDPADENEPTAYEARIASRFGVDDQGRPADRWLTDTVRWAWRTRILVHLGIDLRSRLRQFAEDEAVKVFASNLRDLLLAAPAGTRATMGLDPGFRTGVKVAVVDDTGKVVATDTIHPHVPANRWDESLAKLGKLCKAHAVDLIAIGNGTASRETDKLAADLLKLNPDLRLTKVVVSEAGASVYSASAFASAELPDLDVSLRGAVSIARRLQDPLAELVKIDPKSIGVGQYQHDLAEAKLSRSLDAVVEDCVNAVGVDLNTASVPLLARVSGITTGLAENIVSHRDANGPFRSRRSLKDVPRLGPKAFEQCAGFLRIPHGDDPLDASSVHPEAYPVVRRMQDRAGVELIGNTTALKTLRAQDFVDDKFGVPTITDILRELEKPGRDPRPAFKTATFAEGVEKIGDLKPGMVLEGVVTNVAAFGAFVDVGVHQDGLVHISALSDTFVKDPRDVVKSGDVVRVKVLEVDTTRKRIGLTLRLNDEPGQGQGKKEQSRGPRQDRGGQPDRGRQQDRGRQDRGRRQDDRGARREAPPANNAMAEALRRAGLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY3</accession>
    <name>A0A7W7WXY3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021398">
        <property type="entry name" value="DUF3037"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11236">
        <property type="entry name" value="DUF3037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14087" checksum="15F4E3CB530EB70C" modified="2021-06-02" version="1">MSHVFEYAVVRAVPRQERGEFVNVGVLVYCAPLGFLGARVHVDEDRVRALDPFLDVEILRSSLSHLTASCDGLSAAGPVSRTTVGQRFRWLTAPRSTIVQTSPAHTGLTADPEAELDRLLDALVRPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY13</accession>
    <name>A0A7W7WY13_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine-5'-phosphate glycosidase</fullName>
            <shortName evidence="6">PsiMP glycosidase</shortName>
            <ecNumber evidence="6">4.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psuG</name>
        <name evidence="7" type="ORF">F4559_004965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribose 5-phosphate + uracil = H2O + psi-UMP</text>
            <dbReference type="Rhea" id="RHEA:18337"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="4.2.1.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the pseudouridine-5'-phosphate glycosidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.70" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046113">
        <property type="term" value="P:nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01876">
        <property type="entry name" value="PsiMP_glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="PTHR42909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="SSF110581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="30661" checksum="41CB2191F1D66EEB" modified="2021-06-02" version="1">MSAPSTTGEVRDALAEGRPVVALESTILAHGLPPGRNREVAGRIEDAVRAAGATPATIAVLDGVPRIGLTPAQLDRVCDPDAGLAKLSRRDLGVAQALGLDGATTVAATATLAHEAGIGVFATGGLGGVHRGGSWDVSADLDVLARAPVLVVCSGVKSILDIGATLEVLETRSVPVLGWRTDRFPAFYLRESEFDVPWRVDDARTVARVVHARRTGILLVNPVPAAFEMPRGLHDRLLDEGLRLTADVHGKDVTPRLLRHFHEHSDGASLDANEALVLGNARLAAEVAVALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY65</accession>
    <name>A0A7W7WY65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="24258" checksum="197757A8E4AF0FB2" modified="2021-06-02" version="1">MTALVAVAHGSRDPRSAATVHALLDVVRAVRPDLDVRASFLDLSAPRLGDVLHAVHGDGHASAVVVPLLLGQAYHARVDVPGAVAEARLAALDVTIADVLGPDDRLEDAALRRLGAVVDLDDPGLGVVVAGAGSSHAPANAAVAAVARRWASTRPWAGAEAAFASTASPDVPTAIARLRVRGAERIAVASWFLAPGLLPDRVADLAAGAAVAAPLGADAAVASLILSRYAEALGDVVALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN6</accession>
    <name>A0A7W7WYN6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine cyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="PTHR31270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27281" checksum="40C8B9C5F00BC5DB" modified="2021-06-02" version="1">MRWFPAVVLVLLLAACAEDPHEQPPPVAVLAAIPHDTSAFTQGLELVDGVLYEGTGLEGESTVRRVDPATGEVRRRVDLPAPLFGEGITVVDDRLWQITWQDGVAIERDRSTLAEVRRVTYEGEGWGLCRDGDRLVMSDGSARLTFRDPRTFAATGSVSVAEGGRPVARLNELECVRGQVWANVWQTDRIVRIDPTDGRVTASFDLGPVRPADVPRSDVLNGIAAVPGTDEFLVTGKNWPVMLRVRFGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR0</accession>
    <name>A0A7W7WYR0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine dehydratase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="32225" checksum="EAC5B6BA40034B64" modified="2021-06-02" version="1">MDLVTLDDIRAAAALLDGIAVRTPLLRFDDHLRLKPENLQPIGAFKIRGAYNAIARLSDDARERGVVAYSSGNHAQAVAHAARVFGVPAVIVLPDSAPAVKIDATRALGAEVVLVPVEERESRAHALVEERGATLVPPYDHPNVIAGQGTVGLEIVADAPDLAIVLTPVSGGGLLSGVATAVKALRPDVKVVGVEPELAADTAASLRAGRLVRWPTADRSRTIADGLRAEPSELTFAHLRAHVDEVVTVTEAEIEAAVALIARRARIVAEPSGAVAVAAHLRSPTPGSVAVVSGGNIDPALFTRLTEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT8</accession>
    <name>A0A7W7WYT8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="162" mass="17358" checksum="259ADE0CA26FCB5F" modified="2021-06-02" version="1">MTRAVLSIGSNMGDRQGFLRQAVAGFADVLVAVSPVYETAAWGVTDQDDFLNAVLVVSAPDVDERGWLARGQALENASGRVRTVRWGPRTLDVDVVTVDGVRSDDPELLLPHPGAFERATVLVPWLDVEPDAVLPGHGRVADLVAGLDLSGVHRRDDLALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZH0</accession>
    <name>A0A7W7WZH0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="111"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="20579" checksum="06A4867A186CBA9E" modified="2021-06-02" version="1">MTNPEPTGSAHPARAAGIVLLGVAAVALVIGVASLFVDSDDSTVAGQSRAASTAESTSSATTAAPPVTTAVPAPRTTTSAVPSSAPPAATSAAPTSAAPTTSGQASAKPLVRVYNNSTIVGLGARAAEDVKRAGWEVADTANYSQGQIPTTTVYFRPGTDEEASARQLAEVLHARAEPRFEGIVGAHAGIIVIVTNDYKGTTGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SX73</accession>
    <name>A0A7W7SX73_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GCV_T domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="4">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="38961" checksum="69ABBAAAB945AFE9" modified="2021-06-02" version="1">MNSPLLALPGAVAPFEGAPDQGVPWHFGDPFAEQRAAARAAVVVDRSHRAVLAVSGADRLTWLHSLTSQHFTALGEVGTEALILDVQGRVEHHVVVAHVDGVVYLDTESARAGDLLAYLTKMIFWSKVEVRDATPELAILSVTGPALAEVFDKLDLTLPDAPHGAAALPTGFVRRTPWPGPLSADLAVPRADLAAWWTRLTDAGARPAGTWAFEALRVESLRPRLGVDTDEKTIPHEVNWIGAAVHLDKGCYRGQETVSKVHNVGRPPRRMLLLHLDGSREVQPETGDPVTSGDRVVGRVGTVALHHELGTVALALVKRSVDPSTELLVGAEDRVVQATVDPDSVPADTPGLGRQAAQGFTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXD1</accession>
    <name>A0A7W7SXD1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019662">
        <property type="entry name" value="DUF2516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10724">
        <property type="entry name" value="DUF2516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11826" checksum="FDF2F9D2EB2DAFDD" modified="2021-06-02" version="1">MLSIHLPPFSPLYLDLWVLLILQSVALVMGLFAFGHALTQRAEAFQAAERMTKPAWLGITGGGTFALILFELLGAGSIFWVAGFVAVSVYLVDVRPRLIEIQRGPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXS5</accession>
    <name>A0A7W7SXS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type VII secretion protein EccE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EccE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021368">
        <property type="entry name" value="T7SS_EccE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11203">
        <property type="entry name" value="EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03923">
        <property type="entry name" value="T7SS_EccE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="444" mass="46007" checksum="7C495C696CA084A5" modified="2021-06-02" version="1">MSVSTPHPGTPNPAARAQAAGGAVRAAVLRARRRTAGASLGSLPVANLVVLEVGVAIGLILLAVGTTGDRIAPALLYTAGGIVLVALILAFTRSRGRWLTQWIGLVTRYTFRGHGRTVRRDGPVEQKAPSEEETSVIGPDDPRVALLRLAVPDLVVAKGVDHERRPLGMAWHQGAWTAVLLVDPAPGLITAVGSAPALPLGALAPCLEDRGVVLDAISVIWHCYPGSALLPVNSPALHSYLEVLGPLPAAARRTTWIAVRLDPKRCAAAIRERGGGVVGAHRALIGALSRIRNALESTGVTIRPLDSDELLRAGISAAELNSVAGSDKSVSLREKWSGVTAGGVGHASYAITGWPAKGMRNNLNALTGVRALSSTLTMSISPSSEQGKVGLRGIVRVSARTPSELDKADDRLKALAGKLDIKLTPLNGLQVSGLASTLPLGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXV0</accession>
    <name>A0A7W7SXV0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane biosynthesis protein TonB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031350850" evidence="2">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="3">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="372" mass="39228" checksum="660D407E24AC1574" modified="2021-06-02" version="1">MIAAVVCALLTAAPGSVATVPTAAPPRVEPVRAVEYRTSAKPRAADDTPNDVIRDVGPPPAPPEPEESALPLPAPADHGIPSNVLAAYRTAEKALAESHPGCHLRWYHLAGVGQVESGHARGGRATPDGEARPHILGPVLDGGAYAAIHDTDGGEHDDDPTWDRAVGPMQFIPGTWRRYGVDGNGDGVTSPHNIVDSAVAAGRYLCSGDFDLERQSDLDAALYRYNHSKTYVELVESWMRTYSDGTVEVTPLAPGEEEKPPTETPEPTPTTEPTTTAEPTDPTTVDPSAATTPPTTTDPSTTEPVGPTPTPTEPPPPPSESQAPTTTEPAEQAASLITAEDCAHRDYAELVAKLEHSPFAATIIARLCGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY45</accession>
    <name>A0A7W7SY45_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30486" checksum="236404DF4269F361" modified="2021-06-02" version="1">MTIDLRASTEYEVLRAAKVLARIDEAARQAWVHYLVVGATARSLISFDLSGRSPGRQTRDIDIAAMVDSWEEFDSLVRTLARCGNSVHKFVVEGTEVDVVPYGGIERRDRTIVWPDDHAMNVLGFREAVETARTVFLPDGAIVKIPSIPALALLKIFAWRDRHRDDTRDALDLATMIEWYSSGKYFDALYGENVHALEKFDYDPLPAGAWLLGAHISALLDDDGVAALLLILDDRELTGRLAADMRSPRSRIVVEAVGRGVHDAVDDARKLQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ73</accession>
    <name>A0A7W7SZ73_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="33067" checksum="ED60D815505D7830" modified="2021-06-02" version="1">MRRLLGANTLWIGLVLLVLIAVFGALRPDAVLTVFTLQTTLVETAVLLVLSVGMTYVVITAGIDLSVGSVLVFSGVTAAMTMNALSGGDATDAGWGVVVVGLLVAVVSGAAWGLLNGVLVARAGIPPLIVTLGSFGAALGAGQLLSNGSNVGGVPEVLADSLGTGTWFGVPDLVLLAAVVTALGALVLGTTRFGRHTYAIGSNAEAARRAGIRVTRHLVRVYLLAGTLAGLAGFMALAYFRVASITGHDTDNLNAIAAVVLGGTSLFGGAGSVIGTVLGVFVPAVLRKGFVIVGVNVYWQPIAVAVVLVAAVWFDQSRRKARDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG2</accession>
    <name>A0A7W7SZG2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="23168" checksum="7BCCF49CE1AEA65B" modified="2021-06-02" version="1">MRWFRRPPRVAAAHVPNPAEAAEAFWRGWFELLPAVSAALGDREPQRFENDLCELVAAVHPDLHFTVERGQRAIYALVLSGQEDPRLRPYTDAWRAAAPPEDMIWEYHDSVPPVPDPTAVTVNLGAHRVGLADVRVAARIVAGVVDVAVYHPGFAALDDEARRTMTYLPLDVTLGERLAAERLGRVETALTDPADSIDLLALRTLVTSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T076</accession>
    <name>A0A7W7T076_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="16745" checksum="5E93AC39600AB35B" modified="2021-06-02" version="1">MTVLLREAIGDRLRHARTTQRRTLREVSRTARVSLGYLSEVERGRKEASSELLAAICDALELPLHELLHLVASDIGAVRQSVPTTADLTADLVSADLVAGDLGSTERVEVTTSGSVETGSLLPAVIGNDLSDLRLQPMLTHRLSTPLGETRGAVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D4</accession>
    <name>A0A7W7T0D4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR03083 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="26252" checksum="EB53A637A6CFA4D3" modified="2021-06-02" version="1">MDTARLATTLRTQTTRFAAAVTAADPTLVVPTCPDWRVRDLAAHVGQADRWAAGIVRTGVPAPIPDPADADPGDQAAWAKWLAEGAEELIDAVRTTGPDTAVWTLFGSLPAVFWLRRMVSDTTVHRIDASLAAGIVASIDDDLARDVVDEGLELLTAPTAADLLPALANLRGDGQTLAFVSPTAHPWHLTRTPDGVTRAHDRTDADVVVTASTPLLLSVITRRTPPTRATVTGDAALLDHWLAHTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K9</accession>
    <name>A0A7W7T0K9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045592">
        <property type="entry name" value="DUF6461"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20062">
        <property type="entry name" value="DUF6461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="525" mass="56480" checksum="EF0BC37FA5725DEA" modified="2021-06-02" version="1">MGDYDTFATTVATLIRPLADSLPAAVAADLARLPATRRRSLDDVLRLPSLADKRVLDGVDPPLLVPPVDPPPPLRGSFMTMGWVGESPLATESRLADTLRPGTGDLAEDLVVRLADHPDVASALAVPELDDLDVLDGRHGARHIALALLVTKSILGEDATRPAVLGIALDVVARVLPGRPKPARHADAVLARRRADYRFPAYGSRHVPTPDHWFALTPGPVEAVPDFSANGLVAVLPEGIAVRVASDEVVLVGVDVTATPPEADLSGWEEIVEVSFHTDTGDLGVAGWPVTPPWPGDLRFRVHASGRDGDHREYFRVQVWEAPLAPEKVVKRTDRLGHVLRGETPPDTPSAEHRPYLWVEESVLSVAATITVVTGASVDHVVASFDGRREDHSARDALEGYGGAILLDIGDTVFIVEINGYWGSWERYLGPASAHGRAASAFWNVNGSRRLSFAERGRLLGSFEPPFDDVPAAVAEWCDGLDLADYRSADAKMLAALARFTGHGFVRADYEALTKHGVAYILGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M2</accession>
    <name>A0A7W7T0M2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="11819" checksum="D7353D455A2C6346" modified="2021-06-02" version="1">MARLNTHVSVNGDWYGPDDDVPDEVADRITNPDVWSEPPSRRVQESEPDAEGEGEGPADMPVPPPRRGPGSGGPAWIEYARQVGVTGEFDSKDALIGELERRGLLPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M5</accession>
    <name>A0A7W7T0M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-hydroxybenzoate 3-monooxygenase</fullName>
            <ecNumber evidence="2">1.14.13.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018659">
        <property type="term" value="F:4-hydroxybenzoate 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="38"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="47155" checksum="B741444B73C36EA8" modified="2021-06-02" version="1">MKVDPLPSVSIFAQAVQRQGYAVSDLHTESAVQTNQRPVGIVGAGPAGLTLANLLHQADIPCVVLEKGTREYIETRPRAGVIEHRAVRMLDDHGLADRLLAEADRHGACEFRVNGEAHEVDYSSLYGGQTHYVYPQQEVVKDLVRHFLDAGGDLRFAVRDVRPHGIDTTEPALTWVDADGHEQRLDCSFIAGADGFHGVTRQSIPAGALQEYSHQHGIEWLSILAEAPPSTHKVIYALHPDGFAGHMLRSSTVSRYYLQVPVDDSVDNWPDERVWSELHKRLALRDSDWRLTQGRITEKRILDMRSHVVEPMNHGRLYLLGDAAHIITPVGAKGMNLALHDAEVLAAALIGYHRSGDDRGLREYSDVCLRRVWRAQEFSQWMVFMIHRSPEPFLSRLGEARLQHLIGSRSSAGYFAQNYVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R8</accession>
    <name>A0A7W7T0R8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="293" mass="32150" checksum="B077E78086CA4E3C" modified="2021-06-02" version="1">MSIVEVQGLRKAYGSVKAVDGVDFTVAEGEIFGILGPNGAGKTTAVECVEGLRAPDSGTVRVGGYDPVRDRDRVTRILGVQLQHSELQPKLTVREALELYGSFHREPADWRPLVERLGLEDLLDRRFGALSGGRKQRLFIALALIGNPKVVVFDELTAALDPRARRETWRLVRDLNDSGVTIVLVTHFMDEARHLCDRVAVFDRGRIAALDTPENLIKGSPVVISFRPVTPLPDLAGLPGVVSVTGEGAKVVIEGTDDTVGALLVRHRHEVRELRITDATLDDAYLRITREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T129</accession>
    <name>A0A7W7T129_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (DUF58 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="199"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="419" mass="44259" checksum="E8C1AF1180600521" modified="2021-06-02" version="1">MRGALSGLTTRGRCLLAAGVAAGLCAVLLNERDLLRVSVFVIALPLLAAWLAGRARVGLHATRFLYPGRVQVGAAAEARVELRSTGRLPTGGLLMEDGVPYALGARPRFVVERLPRNTVTALRYPLKPVMRGIQQVGPLMARITDPFGLAEFDRELAGRSRLVVVPRVTGLTGLPGGSGMGAGDDGSIRLRAGQGEDDAVVRPYRHGDDLRKVHWRSTARRDELMVRVEERPWRGGTTVLLDHRLTAHRGSGPGASLEWAVSFTASVCLHLHRFGQQVRLIGDDGHVLAGGSSEGGHSDAVVLDVLAGLQASHRAAPALGLDAGAGQELIAVLGACSPGVVDTLIRNRPRGVRSLAVVIDVRGWALPNEDPAPDASEALALLRAAGWGAVVATPAVSMNQVWQELCHSAGSRPTRAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T133</accession>
    <name>A0A7W7T133_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030557450" description="Peptidase_M28 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="223"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="442" mass="46769" checksum="AA8C82DFFD1361FF" modified="2021-06-02" version="1">MRRRDMLTGAVVTTGAAVLGLAPTARADGWGDRLVAERVRSQRALHHLRVLSEGIGQRIGGTESEHRAKDYLVSVLRELRYDVAVQPFSVPDKYLSTLKVSGQRWNAAAARLGALDVTRSGRVVDLGDGATLPDDLTGRIALLVNVPAPYTPVVEAARRGAVAVLLGRITTPGKSGTFSPALTEAVAVPVLGIAQVHVERLRARPAREITVSTSLHAGLTSHNVIAERPPTFGSDEGVVMVTAHYDSVPGSPGANDDGSGTSLVLEVARVLRRLPTYRTLRFALWGSEEQGLLGSRHYVGGLSDVEAKRIVGTFQNDMVATSNPGSTVYWLLSVDGAANATTSAVADAAGRLGHAGHVRGPVARGSSDHVPFHERGIAAANFSWRGPAGPGDLEPLYHTPEDTLAGNVDARRLQISLELVGTAAYRLAATRSQGRESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T134</accession>
    <name>A0A7W7T134_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.28" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008667">
        <property type="term" value="F:2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003560">
        <property type="entry name" value="DHB_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01397">
        <property type="entry name" value="DHBDHDRGNASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="20598" checksum="E2E020070E229129" modified="2021-06-02" version="1">MTAKIVLVTGACTPLGGEVAEALARQGAVVAAVDSDGRTLSAMVERLRAEGLRIAGRQIDVTSSAAVDALVDQLERELGPIDALVTVAAAIRPGPVLALSDADWAHSFAVNTDGVFNTSRAVAGRMVARRRGVIVTVAGHGATTRSAAYTASRAAAIAYTECLAQEVAPRGVHCAAVAPTDPTRVAQEVLFLLTTPTRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T148</accession>
    <name>A0A7W7T148_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_002004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8047" checksum="2C089287BA768A3D" modified="2021-06-02" version="1">MILFLQILLIVSSLLLILLVLLHRGRGGGLSSLFGGGMQSSLSGSSVVEKNLDRLTLFVGAVWLIAILGIGLMLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T8</accession>
    <name>A0A7W7T1T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="241"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="480" mass="50905" checksum="7138C474A637C366" modified="2021-06-02" version="1">MLRRVNRLDQALMRRSAAIRPTGLDEGMKRLSKAANHSVLWFAVAALLAARKGRPRRAALRGVAAIAGASAGANLVGKTLFPRRRPAAELLDLPRRLAKRPTSSSFPSGHAASAAAFTTAIALESPATALVIAPIAAAVAYSRVHTGVHWPSDVAVGALAGVGAGLLTRRWWPAGREDAASAREHAHLEALEEGEGLVVVVNPGSGLGGPLPGGASPADRIREELPKAVVVDIADLDTVMTDHSPRALGVAGGDGSVAAVSALAAEHRLPLVLIPAGTLNHFARDVGILDLADTAHAVGEGNGVLVDLSTVSVDGADPRWFVNTASLGGYPDMVRLRERLRNRWGKWPAAAIALGRVLRSAKPLRVELNDEPHLVWMLFVGNGPYRPKGFAPTVRPALDAGVMDVRFIRADTRLSRLRFFVGAALGSLHRSRTYRHMEVRRLRVRVLGRPVAIATDGEVGPIGTSFDFVSRPAALAIYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y1</accession>
    <name>A0A7W7T1Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoadipate enol-lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042952">
        <property type="term" value="P:beta-ketoadipate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026968">
        <property type="entry name" value="PcaD/CatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02427">
        <property type="entry name" value="protocat_pcaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26327" checksum="9B2DE3B8F95B6461" modified="2021-06-02" version="1">MRPHHTLDGPPDAPVVVLGPSLGTTTALWEPQLDALTGHFRVLRYDHRGHGGSPAATGPFRIDDLAEDVLELLDGLGIAKASYCGVSLGGMVGMWLAGHAPERVDRLALLCTTAAFATSRPWTDRAAAVRSNGTGSIASAVVSRWFTPEFRDRAPETVRAFETALSTVDDESYAGCCEALAALDLRPVLPAIEAPTVVVSGASDEATPPAWQRAIADAVPDAKLVGVPGAHLAGVESAAEVTAVLLDHLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T200</accession>
    <name>A0A7W7T200_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MocR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="469" mass="48922" checksum="630A7E031BB623D8" modified="2021-06-02" version="1">MDDDNAEAGVIRLLRAAAHTTPPGGRLPSVRAVMGELHVSPVTVQNALRRLVAEGIVEVRPGKGTFAASTPTAVHPTPDLQWQSVALGAKPPGDEALPELLAVPRPEAVPLSGGYLDPGLQPTAALGAALARAARRPDAWARGPVEGRDDLRAWFAREAGGAFRAGDMVVCPGGQAALSTALRALTVPGDTLLVEAPTYLGAIATARAAGLRVVGVPTDADGVRPELLAAAFARTGARLFYCQPLFANPHGATLAVHRRAEVLSVLSGAGAFLLEDDYARDLAIDGTPPSPLAADDVHGHVIHLRSLTKSAAPGLRLAGIGARGAAGARLRTARVMDDFFVAGPLQEAALDVLSSPAWRRHLAALRIALRTRRDTLLAALATHLPEVVPVTVPKGGLHVWVRLPEDWDDLEVTSAAIANGVVVSPGRPWHAGDPPGPHLRLTYGAAGPEILAEGVRRLAEAAHAIRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T211</accession>
    <name>A0A7W7T211_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ORF">F4559_001961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="27359" checksum="1E0BA01998081968" modified="2021-06-02" version="1">MRFGARLHRAIAERGPLCVGIDPHPGLLDAWGLPRDVSGLERFALTAAEALGDTVAVVKPQSAFFEAYGSKGVAVLERAIAELRAAGALVLLDVKRGDIGSTMAAYAAAYLTDGSPLAADAVTVSPYLGFGSLAPAVEAATASGRGVFALALTSNPEGASVQRATAADGRSVAQAVVDEAAALNAGVEPLGDVGLVVGATLAELGVDLSDLRGPVLAPGFGAQGATVADLRRLFGADLSGVLPTTSRDVLKHGPGAATLRSAVARVRDSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T255</accession>
    <name>A0A7W7T255_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002548</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001919">
        <property type="entry name" value="CBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012291">
        <property type="entry name" value="CBM2_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00553">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00637">
        <property type="entry name" value="CBD_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51173">
        <property type="entry name" value="CBM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031575372" evidence="3">
        <location>
            <begin position="24"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="CBM2" evidence="5">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="140"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="545" mass="56088" checksum="0104F7970D7EF9E8" modified="2021-06-02" version="1">MRKRLAVLATAGICVAAVTTSGASTPAAPTAEFERKSVWSTGYGGQYTLVNSGDTDLADWVVEFDLPPGTTVLRAWSSTFTTDGRHYRFTGTGYNDTVRAGTSTTFGFTSQGLGLPLNCRVDGVACDSSAPLPDTRPPEAPAGLVVTGASIGSVSLSWNPATDDVGVVDYRVSVGDVEVTTTSTTGVVVDGLSPGTGYRISVRARDAAGHTSEPGVLAVATAPALSTVDVRTADGLRAALAGAEPGTAIRLAPGVYRGPFAITRPGRAEAPITLSGPPTAVLVGAVEAAQGDCPSPDRDAGYGVWVYEAPWWNLSGFTVRDAKKGVVVDRSPHTVLDGLSVHHIAEEGVHFRGSSADGVLRSSTITDTGLGQPGYGEGVYVGSAASNWGCHGTVDGVDRSDRVRVLGNRVGPRVAAEAVDVKEGTSGGVIRGNVFDGTGISGQNSADSWVDVKGYDYLVEENTGSFASPGTFANGYETHNPVTVPAFPNGCGIVWRGNRSDLGGVGRYAIKITSVSKCAERANVVHASNTVERAVTGLTNVGVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R9</accession>
    <name>A0A7W7T2R9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13533" checksum="816F3CB3DBE3DF4C" modified="2021-06-02" version="1">MLDETHTQDGATPATGAPAHSALADTLADARRLLADAATALHTATPDARDVAAVITETRAVTTTLAGVVAAVMDHTTILADRHAPEIRTEILADLRALHGCLTTGALLLAPALDDLRATAADTTHEREGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T372</accession>
    <name>A0A7W7T372_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="32296" checksum="AC16573A26CA653F" modified="2021-06-02" version="1">MRSEGKPGRWRIDAPPLTSTQAERWSAAWPNQGCPPLVAWVVAVVAVLVAGGSTNPLVWAAPALLVWRPTAGAVAVLIAAVWAFDDPVSRIGFGVYALVCLVMSALRPWWARRQRRALGDLPVVVVGVPADGKSTPGSGSRPIMLGLFAIAAGLLWWPWGPAGAAVPAFLVAVLAGRAVAVRIHGRRLLSKPHRAVGVLVRLDPGGHAILFTADRAVRRVGRFTVATMVHRPDDPLPADFLGTSARTPRTMVEATAVGDFRHNGYIAVVADDFVLLPDSPLHADHDGEITVPPALVDGRRSSGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T378</accession>
    <name>A0A7W7T378_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="29"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="44955" checksum="DD1F425B9F29A558" modified="2021-06-02" version="1">MCAACGVPTHDPQAAPVTGSAAPPRKFAALRNKDCRPYLIGTGLAMMADNIEHVITYWVLWEKFRSPALTGFQVISHWVPFLLFSLWFGALADRYDCRRVIQAAQVLFMAVSAAWGVLFLTDSLTVEWACVLLVLHGLAGSLWTPAEQLMLHDFVGPEELPSAVRLNATFRSLGILFGPVVGSALLLGLGPTWGIFANIVFYLPLTVFLFRTKFTGHTRDSAPRTRIGALESLRVLREVGSNRTLVSMIILAGLGSFFVGASIQSAMPTFANDLGAGSEGTAYGVLLFANGIGGVIGGILLEATNRVKPGVTAAVIATVIYGVSTLGFALTGSYLLAVVLLVVGGVANLASMSICQTVVQLQSPPDKRGRVLGVYGMSSGGLRAGSGFTVGVFGAFVGLHTSLAISSAALCVGTAAAGVHALRGRRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T381</accession>
    <name>A0A7W7T381_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="541" mass="58142" checksum="15E4FF0DA26ED7C7" modified="2021-06-02" version="1">MFDERWAEVPARPVATPWATRRAARSVLGVVHNVTSATRLFDVLPLLAADPRVQVVFSCTGSSPFTPGTVEHLTGLGALTVPWDQAVRTRFDLAVSASHGALESLDVPLVVLPHGIGYNKYLARGEGDRLPVFGLSPEWLVHDGRVIPTSLVLSHTEQLDRLAVGCPPAVARAVVAGDPCFDRMLVSRPLRATYRSALGVRRGQKLVVVSSTWGRDSLFDHAADVVRRLRFDLPVDEYRVVLALHPNTWFGHSSWQVRTWLDECTRAGVVVLPPEEGWRAALVAADVLVGDHGSVTYYGAALGIPVLLATRAVDAVDPASAVGRFLAVAPHLDPTRPVGPQIDRAATTPETRAAAGLVTSAPGGSAALLRAELYRLLDLPEPPGRAEVRTVPTPRVAEVPVVQHWVRVADDRVTRFPADPSRATPAGCHLVVGTDTPRADLLEAADVVVNAEPGDAHVWTAETFDALPGALVATMPLEPGRWLVAIRGDEPLVCTGPDRFGPVWASILLDHWTRELPPPSRITARLGAEHADAEVTAFARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T397</accession>
    <name>A0A7W7T397_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="105"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="32311" checksum="3B5E3CFB462CC0AB" modified="2021-06-02" version="1">MTQANIPPAVYKQLAAELKALRGKRRQDDVIATLLAMPDPGAWSVSKLSRAENALIRLQPDEVEDLCAVYEVSAEDVARLKRWARASRSKNHWQRRMPGLIEDLTELLEYESSAAVQRIWDPTLVPAICQTPGYAAAVISGIKRDIDSADLERRVDARLKRAEILPESQELHLLLDERVIRGRIGTIPVQIEQLRHLAVIAQHPKTTLQVVPEYAGAHPGLIGWFMLFEFSDATPDIGYTDGPGGCVYLRDAEDIRACTLRFGQLSGLALTSGESIALINRVIEEISSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G1</accession>
    <name>A0A7W7T3G1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CspA family cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7821" checksum="C730EEC16DEC2A1B" modified="2021-06-02" version="1">MAERQNGTVKWFNDEKGYGFVTPESGPDLFVHFRAIETSGFKSLQEGQRVSFEAVQGQKGLQADKVRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T3</accession>
    <name>A0A7W7T4T3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031256614" evidence="1">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="33461" checksum="35341E818E03A18E" modified="2021-06-02" version="1">MTVVLSLALGSAAVTGASAATAAAPYCYEETSTPTAGIADLKSSFTSANWMQTLQAMYKRRWPSGEALAKAQVNDKYWNQFVRKENFEAFAESMMVAIHEETHMWDLDGSRTRWNVHTAAWIDATRQATTVPLHDGFARKEIIPLIKDKFSDSMDGIYLRDRTQGEYHLQGILAELNAGLTGLPAVTVVQEYIKGVGASNARDIAATNLRYLLLYLRVAKDRHADYWAKIKNEPKLRELVLTQFLRTAYWLEKSAPYTGRIGGPNADKITATNYAPENIAIVEEFTGRKIDTGTRKNCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T4</accession>
    <name>A0A7W7T4T4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="691" mass="76531" checksum="33F816F5D71D80AA" modified="2021-06-02" version="1">MTTVEDEQPEDDKKPNEAAQDKANDPGTSGRWRNFSAATDVAFAALLGGGTANLFLGDATVGQVGDRATASGHLGAVVRSGPVPRAELDRIRSSFVAPSRYHDLRAALDDRFLVLVHARPGSGRTTAALRLLDHLCPGGVRKLDPDADLKTLRDKDFEDDHGYLLDSLDPAQARELRLFQLDRLARLMEERGCRLVVIVDETTVLPVRDVGHLVVADLGTVGHEALVRKYLDGDAAVLDRDDVREVLAELSPDLPCRAVVDLAGLLRDVAAGRADVAAVRERYSRAGEDAFVEWFESGHDTDQRAFAIALAVFNDQPVQLVSEAGALLADMIKSVETARRSDRTRPVFGVRLDRRVADARAVLVRGTEDTEFGRVPVTKIRFTDDRYAYRLLRHLCDQYDQAYDIVREWLLRLGEIPGDQVRIRAGMAAGLLSLHDFIGIHDRVVDEWARSGDENARWAAVAALRIPGQDAGLGRVVYKMLRAWSRPAQPQALRLTAAQALGSATAMSPAACLRLLRQAARFADWDIAFAIGESMCELYCRVEDPAQVLGALVRWTHDDEHPKRRETALLAVLIMSSSVVRPDEGGGRWPALIWDAEHVPERRAQVVLLYARMLQAAEFMLRGYLALKGWVRSAQRDATLRTPLARLLHEVGAASDETDSVRHYLETWRDEHDGPADAVRDVLRHFDRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T587</accession>
    <name>A0A7W7T587_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="161"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27849" checksum="E86A62A387E543B6" modified="2021-06-02" version="1">MPIVAVEASVSEHGGQPEQPLIPTDLLQFPDAARLELDHAIEVLVHHAQTVRNAQDRLRALLRANHLVASHVDLPDVLRHVVDAAKDQQHRLFTVVRKLDQIVRDIRGTIFDLHSQPAPGETAAPSLRRTLTEIVRTTTDSLGFTPALRLDGPLDTFVPPTIATDLSAVVREALSNTARHARAATATVQITATPTTLIARIEDDGRGIGDTTRRSGLANLRARAEKHSGTLTIDSAPEHGTTLTWTVPLPQNDQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L9</accession>
    <name>A0A7W7T5L9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10100" checksum="1BCE01CB456CCE21" modified="2021-06-02" version="1">MTTTEMPAVHECTVTGCSYNHDGCHAFAITVSGTNGAADCGTFVPLQTKGGLPKVIAQVGACSRADCTHNTNLECTASGVRVGPGSGDHAANCLTYDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U9</accession>
    <name>A0A7W7T5U9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17046" checksum="F6CC80ABD1EB6403" modified="2021-06-02" version="1">MIDYDYWSASMPCDEDLLPALGRVVWASLRLHHAVRDALNDVEGAPSDAPFDLPLGHAVARLRDAAARVAEPARTDLLEWCDGPGARAASSRDGVLGSITFTAPDGRQALGSRLPGRPTRYGPADLLRVVGDLVYADTQLPRGPYPRADHPLGPYPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T610</accession>
    <name>A0A7W7T610_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLA2c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="3">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="700" mass="75767" checksum="90D1D1E58CF3B329" modified="2021-06-02" version="1">MPIAPRPRGDAPGVAAEYVAEPPEGLRIGIALSGGGVRSAAFNLGAVQALRERGVLDNAEYLAAVSGGNYVASALAISAARSDPVLENGKPLWGRGSPEERYLRRHTDYLAPGLVGKLWLVAGVVYGFVLNYLPFVLSAVVLGRVAGWGLAALGVRLSDLRLNGLSMPASPVLVGLLLVGAAAFVGALLLVLYRRWFKNDNPGDYGESLSEKAASALLITTGVVVTALALPPAAQLYGVASRTVLAWVFGEPAERFGTLTGRLVVAFVWLVVSLLSASVALVLSRRFRARRSMLVLSSAAGAGLLFVPLLSSLEHSTRTGLRSPSDAVGVGVMLAVLLAMAVFVHNRRYSMHLFYRERLNSAFALERRVDDRGRVVAAPIAFHERLYFSDLEPVTKVPKLVVCCAVNLASDVPVGRFAESFTFERDVSGGPLFGYRSTAEVEQRGGLPGTQLTLPSIMAVSGAALSPMMGRFTYPPLRFLMALTNVRLGVWIRNPLHPAWREPRTPPRTALGRLVAMVRNGWLEPGAWYVLREAIGAARAKHRYIHLTDGGHWENLGLVELLRRRCTHVLCFDASGNGGLDIGRAMALARSELGVDIDLDPGPVLSDEDGVSREMTAAGEVRYPSSGEERGQIVYAKAVLTPSATWDLHAFKEREPRFPNHSTGRQMFTDEQFEAYRTLGYRAGLEACERLNIPHRVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T684</accession>
    <name>A0A7W7T684_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Virginiamycin B lyase</fullName>
            <ecNumber evidence="2">4.2.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030854493" evidence="1">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="35634" checksum="5D46C3728DAB5520" modified="2021-06-02" version="1">MAHRLGKVVGGAGLIAVVAALVTTTTATGAPPDAVKQFPLPTPDAAPGDITTGPDGNLWLTEAGTSPGRIAKVTPDGRVTEYPLPAADAIPTSITAGPDGKVWFTQSIGETSTGKIGTITPTGQITEYTLPTADTTPIDLVTGRDRNVWFIESIGESGDHRIGKITKDGRVTEYALPSASTFVGDIALGPDGNVWFTESVGTEESTGRIAKITPAGQITEYALPAGADAAGLAPGADGNVWFAESFLDAGTKLAKITPAGQITEYALPSADVFVNQVASGPDSAVWFSEVTGENPVTKLAKITKDGKVTEYALPSADSDVAGLTAGPDRKVWFTDPTTNTVGTVVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B6</accession>
    <name>A0A7W7T6B6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-aminoadipate carrier protein LysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01206">
        <property type="entry name" value="lysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="60" mass="6492" checksum="81789E866FF35BAB" modified="2021-06-02" version="1">MSKTVLAAECPECAADVGLDADARVSEIVECVECRSELEIESVDPPTLVRAPEVEEDWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J9</accession>
    <name>A0A7W7T6J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="542" mass="59917" checksum="5BF517857620B04B" modified="2021-06-02" version="1">MTDLVPAVTSDVAAMTSAERARLPLTLDVVKAAAEQHGVCVRPVLREVVDLDSGEVRIVGVRCNSTRTSRCPACADRNRRSRMAQCREGWHLATEPVAERHAPTADQVALITYRADLTAEYRRAKHEDAHDQVDDLREALREADADIRAEGVRGGLPAVERTAKPPARSTRRRQDSPNLPRRAVSKRTVGREFAGRYRPSTFITLTLDTYGKVGPTGAPVDPDTYDYRRAARDAVHFASLVDRWWQNLRRVVGFDVQYFGTVEPQRRVTPHAHFAVRGSIPHRIVRQVTAATYLQVWWPPHDHPVYGGDRLPVWNADARTFTDPDTGKALTTWADAVADLDKPAHLATFGPQVHSKGILGGTEEAGRHVGYLTKYLTKSITEVVDADSSPRLADHADRLAAELAVTPCSQRCAVWLLYGVQPQGTTSRTTPGHCKGKAHRRDTLGLPGRRVLVSRRWSGKTLAEHKADRTAFVREALAAAGIETPTTDTARLRWAPVRPGDPHVPSRTELLLHMIAQRLAWKADYERARAVPDVSAVPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z8</accession>
    <name>A0A7W7T6Z8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenite-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031246781" evidence="2">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_ATPase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA_HSP20" evidence="4">
        <location>
            <begin position="327"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="41490" checksum="852A2D64176ED1E2" modified="2021-06-02" version="1">MSARLLLFTGKGGVGKTTLAAATAVALAAAGRKTLVVSTDPAHSLGDALGVPAGADPVEVEPGLHAAQVDPRALVDEAWRDLRGHLRTLLAGAGVDELAAEELTVLPGVEELLALAEVRRFVAEGPWDAVVVDCGPTAETLRLLALPEALASYLERLFPTHRRVVRGLLAGVAGSAQVDRWDATADALGRLAERLERLRDLLTSPDTAVRLVLTPERVVAAETRRTATALALQGIAVDGVVANRLVPDPGAETGAAASWLRTRRAEQEAVLAGLDGLGVVRTVGHRAQEPVGVAELLAVAESLYGGADPLDGVRSGSAAAEMSRDGDDYVLRIAVRVGDSDLGLARVGDELAVTVDGRRRLVALPSLLKRCVVTGAELDAESLVVRFRPDPDLWMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T794</accession>
    <name>A0A7W7T794_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">F4559_005233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19510" checksum="3EE07EDCC273B362" modified="2021-06-02" version="1">MSIEIANESGVGVDETSIVAAARFALDRMGVSPLAELSVLLVELDVMADLHQRWMDLPGPTDVMAFPMDELDSARRPDAAGLGPALLGDIVLCPDFAQDQAEKAGHELLDELHLLTVHGVLHLLGYDHAEPAEEREMFTLQNRILADFRSAAAEAVRQSAQREADSKLLGAAGLEDSGGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7B4</accession>
    <name>A0A7W7T7B4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="8" type="ORF">F4559_005240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="104"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="37004" checksum="92DD99F6FE13DB1C" modified="2021-06-02" version="1">MNADERRFDVLRAIVADYVSNQEPVGSKALVERHNLGVSSATVRNDMAALEEDGYITQPHTSAGRVPTDKGYRLFVDRLSEVKPLSSPERKAIRHFLEGAYDLDDVLRRSVRLLAQLTRQVAVVQYPTLSRSTVRHLEVLAITPARLMLVLITDSGRVDQRSVDLGDVIVEDNVARLRSLLNAAMVGKRLSDASAEVAALPDQSPPELRDAVTRVATVLIESLVEHPEERLVLGGTANLTRNVADFPGSLRQVLEALEEQVVVLKLLAAARDPGTILVHIGEENEAAEMRSTSIVSIGYGSRDNLLGGMGVVGPTRMDYPGTMAAVRAVATYVGEILTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7D4</accession>
    <name>A0A7W7T7D4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="52" mass="6131" checksum="4637925B031E890B" modified="2021-06-02" version="1">MSDRATPFYCPYCGDEDLRPQEEPAYSWLCNSCRRVFTVKFIGLNLPQEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7F2</accession>
    <name>A0A7W7T7F2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10753" checksum="5437A84434EF64EF" modified="2021-06-02" version="1">MNGYDVLPYELRAHAAKLEALAERLGEAVHAARTVSMADGAYGQLCQFLPSVVRGIEDQASDALTAGTKGMADIATQVKYTADEYEQREDDAAVTFGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U7</accession>
    <name>A0A7W7T7U7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_005495</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4968136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="42615" checksum="7EB04BCFBC5770D7" modified="2021-06-02" version="1">MAIPVLITVTGPDKPGVSSVLFAVLTRHGVDVLDVEQVVIRGRLVLGVLVSAEHDPEGLQENVEQAMATVSMHVEVEIGADSKRTARLESSHVLILLGRPVTARAFTGVARRLAALGVNIDAIRGVADYPVTGLELRVSVADDTAVADAQLREALAEVSVRGGLDIAVERAGLTRRAKRLVVFDVDSTLIQGEVIEMLAAHVGCEPQVKEITDAAMRGELDFAESLRRRVALLEGLDEKVLDEVAGSLELTAGARTTVRTLKRLGFKCGVVSGGFTRVIAGLVDDLGLDFCAANELEVVDGRLTGRVLGDIVDRPGKAVALRRFAERQGIPLAQTVAVGDGANDIDMLGAAGLGIAFNAKPALREVADTALSHPYLDAILFVLGVTRAEVEAADAADGLELTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y9</accession>
    <name>A0A7W7T7Y9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent 3-hydroxy acid dehydrogenase YdfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="26430" checksum="0DCEC2E8B33FDFCD" modified="2021-06-02" version="1">MTYDLTDRTAVVTGASSGIGAETARTLARAGARVALLARRAERVAELADEITAEGGQAVAVAADVTDDLAVAVDRVHDAFGRVDLVVANAGVMLPNPIADGRVDQWRRMLDTNVLGLLATVRAFTDDLVAAGAEGRRSDLVTVSSIGSYLVLPDYAVYCATKAAVTHLAANLRTEFGPRGVRVTNVEPGLVETELGDHMDNPRIKADLAAWREAAPPLSPVAIADVIAYTTSRCREFNVRQVVVLPTAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T820</accession>
    <name>A0A7W7T820_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="18669" checksum="19AB8DEC80C738C4" modified="2021-06-02" version="1">MYTPDPVQRPVGPPASGTPARDYLNTRPPGVDQTYAVLPRNLVESMPLAWQQQMTHLLAEFHRTYAHLGWPVYRVVPSRVERLVDLDEDQLAEVGVIMEIDGDGDLVYRDRAGKRIENPDGQTALVSVLDPIPAAYANATQRTPPNGFPQPQFPPSGPLQVQAPPSWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T898</accession>
    <name>A0A7W7T898_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="50"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="30844" checksum="5B004668BB6E6D82" modified="2021-06-02" version="1">MTVTGIDGIAARIQQLESLISGGVRTSQTSSTGFADALSSAMGAGTTSSGTTGADVVADAKKYLGVPYVWGGTDPSVGLDCSGLVQKVYGDLGVSLPRVSQDQAKVGTEVPSLDQAKPGDLIAFGDPAHHIGIYVGDGKMIHAPEPGANVRIQDVWETPSTIRRILPDSGTSSVSSASSGAGRYQALFDAATKKYNLPEGLLSAVAKAESNYDPNAVSSAGAQGLMQIMPATAAGLGVNPLDPTQAVDGAARLLSSNLQSFGSVPLALAAYNAGPGAVRQYGGIPPYAETQNYVSKIMASLGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C9</accession>
    <name>A0A7W7T8C9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030635937" evidence="1">
        <location>
            <begin position="27"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="38"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="255" mass="25468" checksum="0FAC8CA3D74107E7" modified="2021-06-02" version="1">MKVRTLFTAVAVAVGAALATMGSAAAAPAADGGVTPYIVGGGNATQTYSFMVSLQSTSGSHFCGGSLIKANWVVTAKHCVQGRSASSIRARIGTTNRTSGGTVATGAQIITHSSYDIALLRLSTSVTQTPIKVSDSSGATGTATRIIGWGQTCAASGCGGAPVTLQELNTSIVADGSCRGINGAYEICTNNPGGRAGACYGDSGGPQIKQVGGTWELIGATSRAGNNSSTCATGPSIYMDVPSFRSWISQNAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8F4</accession>
    <name>A0A7W7T8F4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="36990" checksum="0F67593A26B4694B" modified="2021-06-02" version="1">MVSGSNPSERRREAPDRNLALELVRVTEAAAMAAGRWVGRGDKNGGDGAAVDAMRKLIGTVSMRGVVVIGEGEKDEAPMLFNGEEVGDGNGPECDVAVDPIDGTTLMSKGMPNALAVLAVAERGAMFDPSAVFYMEKLAVGPEAADVVDITAPVAENIRRVAKAKHSDVSDVTVCILDRPRHESIVREVRAAGARIRFISDGDVAGAISAARPGTGVDLLLGIGGTPEGIIAAAALKCMGGEIQGRLWPKDDEEREKAIGAGHDLSRVLTTTDLVRGDNVFFCATGVTDGDLVRGVHYRAGGCTTQSIVMRSKSGTVRMIDGFHRLTKLREYASVDFDFPPGDEEALPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G5</accession>
    <name>A0A7W7T8G5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Coenzyme PQQ synthesis protein B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Pyrroloquinoline quinone biosynthesis protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pqqB</name>
        <name evidence="8" type="ORF">F4559_005877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the transport of PQQ or its precursor to the periplasm.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PqqB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00539"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018189">
        <property type="term" value="P:pyrroloquinoline quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00653">
        <property type="entry name" value="PQQ_syn_PqqB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011842">
        <property type="entry name" value="PQQ_synth_PqqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0884">PQQ biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="49"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="30734" checksum="38E44181666A0A92" modified="2021-06-02" version="1">MKTVVLGTAAGGGVPQWNCACPTCAEVRAGRLSPRTQDCLAVSGNGVDWWLVNASPDIRSQLVSTPAVAPGPGPRDTPVRGALLTDAEIDHMSGLLTLRGAADLRVYAPATVLHALAGTRATLDRYAGWSWRQVEPEQTFTLTGGLEVTAFPISGKRPKYTDSDVDGHWVVAYRFFDPATGGILLYAPCLAAWPHGFDALVAEADVALLDGTFYSPAEMGVTTGRSGGQAAMGHLPITHTLPELRRHPGVRRVYTHLNNTNPVLDPSSAEHAKLVEAGVEIVPDGTVIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V7</accession>
    <name>A0A7W7T8V7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="33920" checksum="6D4425FFAB581FF0" modified="2021-06-02" version="1">MDDFSATRNLAALGVVLLGAVWFALRPPVLYLPVLLVLFVGAEWLNPWTTFTLFAVLPQVYARLPELRAFLVMTLFAATPWATWYAKTGDPRGMLPTTLSIVLFSQLFSWVLTVIAERNRAIAELSRNAGVAAERERLSAEIHDTLAQGFTSIVTLVQAARSDPEGGARHLDLALRTAKENLAEARALVAALAPAALDGSLAQALDRLVARLEEDGISGAFSVSGTKSLPTTVEVVLLRAAQEALTNVRKHSGAALVVVDLTVTDDRAVLTVHDDGAGFGENPEGFGLRGMRNRVEQVGGTVSATDSDGAVVVVEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X4</accession>
    <name>A0A7W7T8X4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28658" checksum="FECDA3C4E54EBA5F" modified="2021-06-02" version="1">MERPLFVVGDVHGHLAELTRALHASALVDPEGSWTGGDAELWFLGDFVDRGPDGIGVIEFVMRLSAQAAEAGGHVDALVGNHEVLLLGMHRFGDENVPNAPTPRSFARSWLLNGGLRSDQDRLTPAHIDWLTSRDVLKLVDGHLLMHSDTLAYLEWGGTIDAVNKAVRAVLTGDDLEHWWECWRKMTTRYAFRGPDGADTAAEVLASLGGFEVVHGHSVIADQLGVTPDRIDGPLRYADGKVLAIDAGLYSGGPCLVVRLDEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T983</accession>
    <name>A0A7W7T983_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="10" type="ORF">F4559_006233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5031658055" description="Aspartate 1-decarboxylase beta chain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031658054" description="Aspartate 1-decarboxylase alpha chain" evidence="9">
        <location>
            <begin position="25"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16141" checksum="30CE23FA05651629" modified="2021-06-02" version="1">MFRTMLKSKIHRATVTQADLHYVGSVTVDEDLMAAADLLPGEQVAIVDVTNGARLETYVIPGERGSGVIGINGAAAHLVKPGDLVILISYGQMDDLEARVYEPKVVFVDADNRVVDLGVDAAHAPAGSGLLSGAVTASSETEDAAALDALIQAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T985</accession>
    <name>A0A7W7T985_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="18748" checksum="4427E277DB2EBD69" modified="2021-06-02" version="1">MTGSFSPGPQNARPGMTPRLPTPPTGWPIGSYGTYEEAQRAVDFLADGDFPVQEVTIVGVDLMLVERVTGRLTWARVLGTGAASGAWFGFFVGILLSLFNSAPGAGIGPIIAGLVAGIAFGVIFAAVGYGSTRGKRDFQSASQLVAGRYDVLCQPRSAERGRDLLAKLAMRPSDVRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J1</accession>
    <name>A0A7W7T9J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding Lrp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17759" checksum="A69A2053EA5A4233" modified="2021-06-02" version="1">MTSDRQIEHSDQALDALDARLLLLLTDEPRLGVLECSRRLGVARGTVQARLDRLVARGVLTGFPPALDLAAMGYSLTAFAVLEIAQGRRREVSRGLASINEVCEVHATTGQGDLFVRLVARSNADLQRVIDSIVDVPGVQRLSTSIALSTPVPPRVRPLLEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K6</accession>
    <name>A0A7W7T9K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="407" mass="41498" checksum="83C68E79758FB06A" modified="2021-06-02" version="1">MSHSARLTDYRTALTTPGMRGPVVASVLARLPIAMVGLSMLFYVRSVSGSFATAGLVSAASLIGVAVGSIVQGRLMDRYGPTRPLLRVTGLFAVFVTLAVLAVESGAHLAVLMPLTFGVGLTEPMVGSASRALWQQVLPPGNARHAGFAYEAISMEVFFILGPGLAGLLVTAPWAGTGVVLGATSMVIGALWFALNPTVRGVRPEHESRDLLGALASPGMRTVALAALGFGVTIGFIEVAVPAAAAEAGHVGMGGLLLSLWSVSSVLFGVLYAMKPFPRAMHLRLPVLLGGFALLSFLLAVPTTLIGLGVALFVVGTLITPQATTHSAALEQVAPAGTATEAFGWVITAVTVGLALGQSVSGQLVESYGTQAAFVAAGVAGLVVAAAVWAFRGTVAASADVPRLIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R9</accession>
    <name>A0A7W7T9R9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="25168" checksum="A0C99A582932C272" modified="2021-06-02" version="1">MIDLSSKVAVVTGGTRGIGLATVRALAEAGASVVLTGRDEAVAKEKAAAVAAEFDADVSGLALDVTDSKAVAGLIRGVAKERGRLDVVVANAGVLEDALIGMIRDDLVDRMLTTNVAGTIYTVQAAARAMMKHKTGAIVVLASIVGEKGSAGQTAYAASKAAVGNIARSTAKELGRYGIRVNGVAPGVIETSMTSHLGEEVLDKRAADTPLGRLGKADEVARVIRFLASDDASFVTGQIVGVDGGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W9</accession>
    <name>A0A7W7T9W9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="25292" checksum="EA0FEA9EEE5552B7" modified="2021-06-02" version="1">MEISGTAAIVTGGASGLGLATAKALAARGASVFALDISVENAPEVEGVTFVAADVTSEDDVQAAVDRAASGAPLRIAVSCAGIGPSARTVGKSGPHPLDLYRRVIDVNLVGTFNVLRLASAAIGRTEPLADGQRGVVVNTASIAAYDGQIGQVAYAASKAGVVGMTLPAARDLSSVGVRVMTIAPGIVDTPMLATVSEEFRAGLAAGVPFPKRLALPEEYAQLAVSIVEHDYLNGEVIRMDGALRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA36</accession>
    <name>A0A7W7TA36_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative peptidoglycan lipid II flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="544" mass="57518" checksum="2C586B8DD866ABE1" modified="2021-06-02" version="1">MSETVTQENRSDAAPSVARASGSMAIATVVSRASGLLSKLLLVTLLGATALNDSYQVATTLPTMINELLLGGVLTSVAIPLLVRAEKEDGDGGESYAQWMVTMSAVLLGIGTVVAIIAAPLLTSLFVSSSDKANPELVTAFAYLVLPGIVFYGLSALLGAILNTRDIFGLPTWAPVLNNVVMIVVLGVYWVLPGEISLDPVRMGEPKLLVLGLGTMLGVAVQAAVMIPAMRRTGFRFRWRFGWDRRLAEFGGLALWVLLYVGLGFVSMVVLTRVATNDVGAITVYNYQWLVTQVPYGVLGVSLLTALMPKMSRAAAANDIGSLVGDLSFGNRMSSILLMPFAALLTVAGLPIGLAVFSHGESGIAGGTEIGVAMALSAFGLVPYAITLLQLRVFYAMKDARTPTLIQGVIVVIRIALLLLFLKISPTDKLAVAVSIAMSLSFVAGAVVGQVWLRLRLGRLRTGYTAWTICLTVVASAIGFAMAAGLAWLVTAALGLESVRTEAWIDLVVLTVVGLPLSFGLLAVFRVPEVKPAMDKVLRLVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA84</accession>
    <name>A0A7W7TA84_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="16791" checksum="9306E8A52C4DED78" modified="2021-06-02" version="1">MDEGERALAKVGRQRKAMAARIRMPVWFRVVFALAWSGFLAAPALMLEHERLGLGDFPYLPVSFLGLAVAVMGFRHMSALGQSSLVPDYPSLRRLGPQTAALFLGGAAFAWVPAVAGLPYVAIVIALVVGGLASAQACRLNAAIRHDVANGFPVPEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBP9</accession>
    <name>A0A7W7TBP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme-degrading monooxygenase HmoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10941" checksum="1B4D202161B78F4F" modified="2021-06-02" version="1">MAVVKINAIHVPEGSGEELEKRFAARLGAVDSSPGFLGFQLLRPVAGDTRYFVVTQWEDDASFQAWREGSGQAAHAGERAKPVATGADLLEFEVVLSSTPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCE9</accession>
    <name>A0A7W7TCE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="25821" checksum="83B88ABB1E3A16B0" modified="2021-06-02" version="1">MWPEVVAHRGASTAFAEHTLAAYERAIADGADGLECDVRLTRDDHLVCVHDRTIDRTSDGRGAVSSLTFDQLNTHDFGSWHGESADVLELDTLLGLAADHGKQVFVETKHPVRYGDRVEQRLAAVLRRYRVQAVMMSFSVTAVRRFKTLRPDVPTVLLFGHRWPERLPTFADFAGPGVHLLHRYPERGRGAYCWTADSAPDVAMCVERGVRFLATNNPAGTRGMLADNLSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT42</accession>
    <name>A0A7W7WT42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="28386" checksum="5FD0F3F1EE8CECFC" modified="2021-06-02" version="1">MGSDTRTTVTEQVLFGRADLIPDRTRPTGWTVAVDGVSQSYVDTLDPTFLRVPYTRWMGALIDHHWPAGPVDAVHVGGGALTLPRYVGATRPGSRQTVFELDGPLVEFVSRHLPVPDVEVVVGDGAAGLLTVEGADLVVLDVFRGGAVTTELLTVPYLHEAAPRVAPSGLLLANLWDGPDLTFTGHAVAALDAAFAHVTLFAEAAVFLGSRPGSVVVAASHGPLAAQTWTTTPKAFGLTAPQLTGLRGPKTPLTTTNPVQPSATVQPWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTH6</accession>
    <name>A0A7W7WTH6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="124"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="638" mass="68646" checksum="034A11E9870A39A9" modified="2021-06-02" version="1">MRQRAVLVGCVLAALLTAAGLFVTDYGIDPDLWLVAVAAGFLLLLAALDPWVHRRRAAGLSTGDQLAAAARDLVVALKAQWIEESRSRGLDDAPLDLHWSSPDGSAPPGRGDAVVGAFERQPDHRLVLLGEPGAGKSTTALMLTLGLLDRHTAGPVPILLPLSTWDPDVEDVRTWLTRRLYEDHPALRNTELYGSYAAELLVEQRLVLPILDGFDQVARHPGALERINRAFPPSTPLVLTSRTDGFAGCHVPGAGVVELHPLDHEEIAGYLRAHADPVIAARWEPIFLHLRAEPDDRLADALSTPLAVWLAGTVYADGEPSELLDRARFPDRASVEDHLVDMLVTTAFGDRAVAHHARASQVWSRADAHRWLTFLARELHGRGVRELAWWELRRSVGRQWLAVLGALVLGTIGGFGVAWLMAYASTPKLAPITGLAAGIAVAVAALRASGRRSPKPKPGIWRSLVVVSGVLGLAVGLVFGALYGPSAGLVVGLGLAVASALRFALADNAELTHPSSPKWTMARDRIAVLTGSLVLSVTFGTAGGLVFGAHQSGMVGLGLACGLLLGFALSVLHLRWWWFTVARVWLALRRKVPWELMVFLDDARKLGVLRQSGACYQFRHALVQDRLAGPRTSAGQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTS8</accession>
    <name>A0A7W7WTS8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="47" mass="5011" checksum="E24162825619C0B8" modified="2021-06-02" version="1">MDLVVNSVVCQGRYSCATVIPDILLPGQTLTIHDPVGSETLTGRNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUA6</accession>
    <name>A0A7W7WUA6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6950" checksum="2A4FE4EA0D7096FE" modified="2021-06-02" version="1">MSTFTAWRKSSYSGPPDNDCVEVGFGGDGVGLRDSKAPDEGVLVLSRRGWAGFLSTIKSGDAQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUE9</accession>
    <name>A0A7W7WUE9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031355173" evidence="1">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="18882" checksum="B6097ECFB49A2C28" modified="2021-06-02" version="1">MKRRIALLLAAVLGITLVAPVAASATPGYCGIAWGSGVKSTWPTVSGALTNIRSGRQECYDRLVFDFRGENDGYHVRYVDQVTHDGSGEPVPLRGGAFLQVAVHSPAYDPETGTPTYPVGDPAELVDVTGYSTFRQVAWAGSFEGTTTVGLGVRARLPFRVFTLPGRVVVDVAHFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG2</accession>
    <name>A0A7W7WUG2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sarcosine oxidase</fullName>
            <ecNumber evidence="3">1.5.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PTHR10961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="2">
        <location>
            <begin position="5"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="38145" checksum="396625782EF2A4EE" modified="2021-06-02" version="1">MTDVDVVVVGGGAMGSAAAWQLAVRGFEVVLLERFSPGHAFGASHGASRIFRLVYGDPLYVGLALEASALWRELGGDVLTETGGVDHGDLTGLAESLEAAGSPGRLITADEARARWPGLRFDTDVFFHPRTGRLHADNAVTKLQEAATYHGAVVRHQEPALSIKLGDKVEVRTAQDVYRARRVVVAVGAWTTRLLGDLVPLPPLRVTQEQPAHFRPLHPGDWPAFIHRVPDGVYGMATPGEGIKVGHHGSGPEVDPDRRDFTAEPGRFRALRDYVRQWLPGVDADAATPISCTYTSTPNSDFVLDRYGPLVVAAGFSGHGFKFVPAIGRVLADLATSDALADPRFRLSIPAGQGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH8</accession>
    <name>A0A7W7WUH8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14125" checksum="A8ABB760E635D879" modified="2021-06-02" version="1">MAEALLKIGELAARAGVSIRTVDYYTTLGLISPAQRTASNYRLYLPGDVDRIHLVRRLEVQGLPLEEISAALTTTRADVTAILDRITTDLQTLQAAVDGASPQTQGLLAAIATRAHSLITVALQIPPDLLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUV3</accession>
    <name>A0A7W7WUV3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitinase</fullName>
            <ecNumber evidence="5">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030725306" evidence="3">
        <location>
            <begin position="25"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-3" evidence="4">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="372" mass="39454" checksum="8AF9436B90B3BD8D" modified="2021-06-02" version="1">MAAIATVVVGAGTAIAIAGTSASAADCAAAWSASSVYTGGQTASYNGRNWTAKWWTQNEKPGGTQVWTDQGTCGSGPGTGTTTTTRTTTVPTSPTQPAKCTETWVRGKAYVTGDVVRYTDNKYYVAEHDNPGYDPVVSTWYWDPYTGCGDTPTTVTSTSTTQNPNPGQFVVSEAQFNQMFPSRSSFYTYAGLVAALSSYPGFANTGGDVVRKQEAAAFLANVNHETGGLYYVVEQNQANYPHYCDTSKSYGCPAGNAAYYGRGPIQLSWNFNYKAAGDALGLPLLTNPYLVERDPAVAWQTGLWYWNTQNGPGTMTAHNAMVTGAGFGETIRSINGTLECNGGNPAQVQSRINAYQKFVGILGVPAGNNLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUX7</accession>
    <name>A0A7W7WUX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="24993" checksum="F9B5FAFDDC213A19" modified="2021-06-02" version="1">MEKAQLGGRVAFVTGGSRGIGAAVALRLARAGADVAVTCRAQADDVAAAVTASGRRVLVHKADSADVDSVARAVRETVDVLGRVDVVVNNAAEFTTGPVTGLSADDFDRTMATNVRAAWEAVRAAVPHLGEGGRIVTIGSLVAHRVPVPGFSLYATSKAALVGLTKALSRELGPRGITVNVVHPGPVDTDMNPADAPAADGFRAYTALGRYGKPDEVAAVVEFLASPDAAYVTGSEVFVDGGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD8</accession>
    <name>A0A7W7WVD8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional regulator GbsR (MarR family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="18235" checksum="8FFCF509929F3058" modified="2021-06-02" version="1">MTERDPQAVLRFIERFSALLTEAGMPRMPSRVFVALLCTDAGALTAAELAELLRISPAAVSGAIRYLTQVNLVARERETGSRRDVYRVYDSLWHEAIFRREQMLHRWEGPIRDGIGMLGADTPAGQRINETFEFFRFMSEQMSDLLARWRAQRADLRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI8</accession>
    <name>A0A7W7WVI8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="24639" checksum="DE4640A444A55D32" modified="2021-06-02" version="1">MRFEDRVVLVTGAGSGIGRAVAVGFGAEGAHVVLAGRDVERLAEVADAVGEAGGTALPVPTDVSDSHSVDALFREVDAEYGILHSAANCAGVWETGCAADMSDIVWDRVIGTNLTGLWRCLRGEVRLMVEGGAIVNVASVVGRHHSVPGAAAYAASKAGVEALSRTAAREYIGRGIRINTVSPGRIDTLHLAGADHGFGSCPPIGRVGGLAEAANAVLFACSDESSYFVGHDFVLDGGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN2</accession>
    <name>A0A7W7WVN2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amine oxidase</fullName>
            <ecNumber evidence="10">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_002625</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58001"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9 10">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052595">
        <property type="term" value="F:aliphatic-amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052594">
        <property type="term" value="F:aminoacetone:oxygen oxidoreductase(deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052596">
        <property type="term" value="F:phenethylamine:oxygen oxidoreductase (deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052593">
        <property type="term" value="F:tryptamine:oxygen oxidoreductase (deaminating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="PTHR10638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="SSF49998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="SSF54416"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0186">Copper</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Cu_amine_oxidN2" evidence="12">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxidN3" evidence="13">
        <location>
            <begin position="100"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Cu_amine_oxid" evidence="11">
        <location>
            <begin position="220"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="9">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4965266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="635" mass="69976" checksum="2C7DBAC12FB99CFC" modified="2021-06-02" version="1">MTTSSAHPLDPLTEAEIARVREVLVAEGKVGPTTRFPSVLPVEPDKALVRSFTPGSTAPRRVRAVLLDVKTGVTQEAVVDAASGTLESFVDLDPADGRAPILFEEYDRCADLVRADPRWQAAMKRRGVDDWSLAFVAPLSPGSFEENFDNNRRYLRALTFLRDHVDDSPWAHPVEGLLAEVDLITGEVLQVVDEGDVPVPTEHGNYTGVAEPRTTLKPISITQPEGVSFTVEGSEVTWEGWKLRVGFNAREGLTLHRISFNGEPVLYRASMAEMVVPYGDPAPWRNWISYFDAGEYLLGKNANSLKLGCDCLGVIHYFDAAVADDHGNPITIPQVVCMHEEDYGVLWKHTNILTGASDVRRSRRLVVSFFSTIGNYDYGFFWYFYLDGTIELEAKATGVVFCGAGEESPYGAEIAPGLMAPVHQHLFCARLDTEVAGERNTVDEVDFARIPIGPANPRGNAFTSTTKVLETETDGARLADPLVGRTWVVRSADGTNRLGKPKAYQLVPKPGPTLLAQPEATVHGRAEFATKHLWVTKFDENERYPAGDYPNQHPGGAGLPGWVKQDESIVDEDIVLWHVFGPTHLPRPEDWPVMPVDYSGFMFRPLGFLDRNPALDLPDFSADKHCPPGQCGCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR3</accession>
    <name>A0A7W7WVR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="6972" checksum="5CCD7EBF358DE752" modified="2021-06-02" version="1">MEADTPRARQWSIPLVILSAVFLGVATWNGILVVHEPVAWRGVAAGACFLAAISLLSAAVSERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR8</accession>
    <name>A0A7W7WVR8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22834" checksum="69A524B7FB9B0F3B" modified="2021-06-02" version="1">MTTRIPVAVYAEDPVLRTGTTHQLRPRPEVEVLGADEAHRAVVSLVVVDAVDEPTTRLLRRLRRSSATRTGVVVSRFDHDSLQITVDCGVSAVVRRAEADQDRLVTTILALAKGEAVLPGDLVGRLLDHVGRLQRSVLDPDAPTLATLTPREADMLRLVAEGFDTSEIATKTSFSERTVKNVLHEVNTRLNLRNRAHAVGYAMRHGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY3</accession>
    <name>A0A7W7WVY3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="159"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="403" mass="41587" checksum="41880DB230368751" modified="2021-06-02" version="1">MRSSSLGPDFTRLITARTISSLGDGITLAAGPLLLASVTDSPTLVAGGLTALLLPWLLFSLVSGVIVDRVDRRRLVVVVDLARGAVIGALALAVLTDHVSVPLIYVCLFLLGTGETLSDNAARALVPAVVADDALPRANSRLAAVNLVVNQLGAPPLGAALFVLAAALPFGIDAVTFVVAAMIVAGVRGVPKPAPKARATVRRDIATGLRWLWRHDVLRTLCLCLALMNLTLTGGFAIMVLYTRERLGLDPSAYGLMLAASAVGGLPGTALAPALIRRFGAPALLRLGLVVEAATHLGLALTTTAWVAFATMAAFGLHAVVWNVICQTISQRAVPDELRGRVGSTMFLLTAGGSAIGALTAGLLAERFGVTAPFWLGVVAVSALVVAAWRPFGRADATATIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW23</accession>
    <name>A0A7W7WW23_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="48307" checksum="31B1B39D30CD985A" modified="2021-06-02" version="1">MGFGRRTFLQLAGVGAVGLTGHDWSRLRLDGRLVLPGDADYDRVRLPFNLVYSGNKPAAVALCAGEADVARCLEFAARNRIPVAARGGKHSYAGYSTPADGLVVDLSALNRAQVSGDRVVVGGGMRLRELYEELGAAGRLLPAGTCATVGIGGLALGGGISVVGRRHGLTCDRLRAARVVTPDGVVRRVAADADEDLFWALRGGGGGNFGVVTSFEFETSPAGDLVVFSLSFPAGSAVDVLGAWQEWFASAPDELWTACEVRAGSPTPVSIAGTWSGPETGLTPWLNRLAARVRPTRRQVRVLSHLVAMRYFAGCEVSCPPVRGASFVASSRFLAKPADPAKVVALLTGKRAGWAQFDSFGGTIGRVPVTATAFPHRDAFASMQAYVDVGLVDQAEARRTVAALRDGIGGGTGYVNYIDPDMPDWATSYYGPNLPRLREVAARYDPDRVLAFAQGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW64</accession>
    <name>A0A7W7WW64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16314" checksum="D0BCCA99E373DFA8" modified="2021-06-02" version="1">MTTLREATALASTESGLAVVATLRADHTIQASLVNVGLLAHPDSGEDVLAFVTYGRVKLGNLRARPQLSVTFRAGWKWATVEGQAEIAGPDDARPWLRDAEQLRLLLREVFTSAGGTHDDWAEYDRVMAADRRAVVLVRPTRAYSNRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW91</accession>
    <name>A0A7W7WW91_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="20956" checksum="6C42EC06CA806D16" modified="2021-06-02" version="1">MGKIYERIDGRLKAFVEAQPVFFTATAPLAADGHVNVSPKGRSGTWRVLDERRVAYLDFGGSHAETISHLRENGRITLMWCAFDGPPTIVRVHGTGVPVFRDSPGFAELAAGFGEADGPGVRAVVVVTAKLISDTCGFAVPFMDYREERTLHADFFGRKSDEEFRGYCESKEHNQHSIDGLPAVPLPLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWA0</accession>
    <name>A0A7W7WWA0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17328" checksum="AEA24EC40E04C927" modified="2021-06-02" version="1">MLTAALDYLRPGDLLTVQEFDPPGRNLLEGLLALDSHHVRPRDPVTVGHRHHVPRGIAHGCTPPPRTGPAVAMPDDATADGGASRALRPPERRGVGTHDHKTRRVVDSPRSDSTTRPNHLDRDSPGHANGGRDGRSPPIVHYRTIGYHHTPFAVPGSPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWE5</accession>
    <name>A0A7W7WWE5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045428">
        <property type="entry name" value="EACC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19953">
        <property type="entry name" value="EACC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15641" checksum="19A9C2CAAEB45A09" modified="2021-06-02" version="1">MTTATASLRTEGPEDDLGALVKWLRDEDGLRGRVSLAASSPGQGEMGAALDAVVVVLTGGTASVLVRSLFDYLKHRRTTSKVTLRVRGEHGRELDSFSPQSPCLDRTVSWSGGFASDSPETRLDGHVSRFLTLHCVVDHTGGRCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ5</accession>
    <name>A0A7W7WWQ5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4132 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025406">
        <property type="entry name" value="DUF4132"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13569">
        <property type="entry name" value="DUF4132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4132" evidence="2">
        <location>
            <begin position="885"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1156" mass="126374" checksum="89DFF6DC3B6A16DA" modified="2021-06-02" version="1">MRRWESGGRGTVVFREVVRAGTAVTVRSGRGDGRGRASTSEHGSVEAALAHVAELAAGLAAEGFREVPPEELEDVFVPPRRWAALVHPRHDGPVRPKFVLDGGAPAFLHAATEPLSDQAEAVLADPHTEPALAEAVRGHLAGVPDPLGAACVATLVEADRRRERYEGVERIADAWIAEHGLVFAARATVDTGLVDLPWRMGPGGASPRELRFRPPATRYHDLPRHVPPRMRRAIAAASDEEYAAVVEALGAHRIDPITSLIAAYLVPERDDWVDEVVRRIVEDEPGGSDPTMVLCSLNRGDQLRDLVGRSEFAWRLRDAEVLYTVALAVGTGAAEPLLTVVEGDFNNAEFTKRVFDVIAAQPADEAFDVLVSRIDDRYGQAALLEAVRRFPRRAVRRLAAAAPSSEPARALLHAHLREFPELARVDPANAEADRVPDVPVEELPAVLVTPPWTLPRKAGKPAVVTGLVSTGRKAVRWLPGENAEWTTAHRADRRGSPDWMTVVRRFLSGDLRDYEKRVAFLEGPAFALRGMLADWRPTDPWGADTWGRALVAKYGYDALPMALHLARLNPAGAGHLLLPYADHDVAHLMADWLVRLRTAGRTASTWLRRHAEEAARFLLPTALGKPGAARRAAESALVLVPEEARRAAKEHGAQAVAALETLLGTDPLDAVPVKIPVPGPWAAPGLLPQILLRDKLRALPVPSAQHVITMLAFSRPDDEYAGIGVVRDLCDPTSLADFAWAAFERWQAAGSPPKDNWALTALGTFGTDDTARALAPLIRSWPGEGAHAKAVAGLDVLAAMGSDVALARLNGIALRSKFRKLKELAEAKIDEIAGLQGFTTDELADRLVPDLDLADPATTRVDYGPRHFTIGFDERLRPHLTTPNGTHRKDLPKPTASDDPTLAATERKRFTALKKDLRTTAAEQLPRLERAMTTTREWTTEEFTTLLVDHPLLWHVVRRLVWRTTEGTTFHLADDRTPHTITDTPYALAENTKVGIAHPLTVPGPDLAAWTALFKAQRKLPQPFRQLDRPVHHFTPEDKSRRTLPRFEGRSAPVGAVLGLTKENWQRGRPQDGGLECWITRPLPTGGALVATLEPGIIVGLVEEHPTQTLAHIWISRHQEGTWNPEGTRTLAELDDITLSEIAAELTYLTTATTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWT5</accession>
    <name>A0A7W7WWT5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="25672" checksum="E064875D37E4D338" modified="2021-06-02" version="1">MSVFAEWVRDFEDAADRRRDTGDPDFARRAVMAPEVVASVRRFQVGESGDGANLIAKAGDAGDDDYARAVRMFVAEERDHARMLALLLGAAGRDTIAGHWSDAVFVRLRRVLGLRMELMVLLIAEVVALGYYRALRDGADDPLVAEVAGRILDDERRHVPFHCLRLRGDLPRTVRGPWRVLLLGALAVVCLDHGPALRRLGVTRRAFAAEVIGHFDAAVAAVHDPAHDLLPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWW2</accession>
    <name>A0A7W7WWW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NNP family nitrate/nitrite transporter-like MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="3"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="40231" checksum="32A811D59DE277DD" modified="2021-06-02" version="1">MVMLSLATVGFAINFWAWALLSPLGPLFKDSLGLSAFQQALLVAVPVVVGSVGRIPVGALTDRFGGRVMFPLISAVTIVPVLFLGLLGHSSLVALLVGGFFLGLGGTAFAVGVPFVNAWFPPERRGLAIGVFGAGMGGTAISALTTVRLVDTGGVATPFVVTAVVLAVYAVAAAVLLRDAPGRSVPTEPVARRLADTVRLPVTWQASWLYAVAFGGYVAFSVYLPAYLKTAYGLAQADAANRMAGFVLLAVVLRPVGGWLSDRFGPIRVLVAVFAVVTAGAAVQAFTPPLMPVGTIAFLSMAAALGAGSGAVFALVALLAPGNKVGSVTGVVGAAGGLGGFIPPLVMGALYGAFSSYALGLAALAVVAAITLAFTMTTVRRSLHAHQPGESAGARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ1</accession>
    <name>A0A7W7WWZ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="586" mass="63707" checksum="7A456183527B33B8" modified="2021-06-02" version="1">MCGITGRVAFDRDLTRSPEVIEAMTATLSRRGPDDSGVWVDGPVALGHTRLAVIDLPGGRQPMVARTPDGPVVLVYSGEVYNHRELRARLRDHPFRTASDTEVVLRGYLEWGEEIAERLDGMYAFAVWDGRRDALVLIRDRMGVKPLYYHPTPAGLVFGSEPKALHADPAVDRVLDTDGLREAVARVKTPGHAFWSGMRELLPGTVLTATRAGLRTRTYWTLSAREHRDDLPTTVATVRRLLGEAVARQSVADVPHCALLSGGLDSSAITVLSPAGTRTMSVEFAGQEHVADVNRPDADAPFVRDVVAHVGTEHRAVVLDAARLADPAVRATAVAAWDLPISMGDLSTSLHLLFTAVRETATVALSGESADELFGGYSWCHDGRPKTTFPWRAALAPLMTDRMYHPDLVASLDVGTYVADRYREALAEVPPGADVTTHLNLTRMNRMLLDRKDRMSMATGLEVRVPFCDTALVEYVYSVPSALTTFDGREKSLLRAAVAPLLPPSVVGRRKAMYPTTNQSAYVSAIQGQAADLLSSDHAVTPLFDTAFLRAAASAEVVSPVERTGLETYLDMAAWVDATSPKLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX11</accession>
    <name>A0A7W7WX11_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11554" checksum="582191721AF26BDF" modified="2021-06-02" version="1">MGTFSVNSFSRPSGPVNAGLSDKRLWPVVDGDGGYPSGQGMRWRKGRSTGERGPGRGGLHRTKPFTAGSYTYSGLAIALRSTCAATSPAPTRTAVFRDRQLTTRLLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXE8</accession>
    <name>A0A7W7WXE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030748082" evidence="1">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="18184" checksum="D2E56357C1685C57" modified="2021-06-02" version="1">MRVVKVVVAVVLAMVGLAPVAVARSGEPVGLPVIIAEAVALAAGEHPGSEVYGAYGTFAAPTSDPGEATEWLIGFGTDGEGGDFAYAYAPDGTFVEARAWERPASGVGPLGQLDLTQWDAVVRLRDAGIDGAFDAVAVRHPAVFEGEPTYYFCLVDGRETVSVGAWTGGVETGVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH2</accession>
    <name>A0A7W7WXH2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Precorrin-3B synthase</fullName>
            <ecNumber evidence="2">1.14.13.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.83" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043818">
        <property type="term" value="F:precorrin-3B synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="1">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="34767" checksum="E18174A3140D22B3" modified="2021-06-02" version="1">MPQDRVRPDACPGAVDVHHAADGGLARVRVPGGVLDADRFAVLRTAALDLGDGTLELTSRANVQVRGLAPGTEHELGARLRAAGLLPSATHERMRNIVAAPLDDNVDLVAAIDRGLCATPQLADLPGRFLITVGAAVAGLGGDIGLVDDVLLLAGQDTGVRVADPVAAVLTAARLFADIRGTAWRLSEVDGGVARITAVLGTSDAERLTPTVTPVAPGPVGDRVVAGVPLGRLDARLLAGVPVRLTPWRSVVVPAGTDTTGLFTDAASPWHGVTACTGRPGCAKSLADVRADAARWIDRRPHQGRVHWSGCARRCGRPSGAVVEYVATGDGYEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXL3</accession>
    <name>A0A7W7WXL3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="254"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="354" mass="38840" checksum="074247E80C461451" modified="2021-06-02" version="1">MLRLQHSGIWYRNRTATVTPPATICAALIGNTVASLSAAGADPAAIERTLGFGLERLADPDEQLPLGHQARLERESPRLTGDPAIALHLAARCRGNGGDVGIVGHLAAHSPTVGDGFHQVIRYANLLGTGIVLTLRRRDPTAELFYVRTDPTTATVQGAERALAETVMTLRQLAGDALDPVIARFRHPSPAYAAEYRAVFGDAVRFGQTDDSVTFPSAVLDLPSPQAQPYINRVLTEHANALLERADATRPYRRRVEESILLQLPHGPAGIDRTARALGMSRQTLYRRLKDEGTSFQALLDDIRRRSAARYLAEPDRALGDVAFLLGFNDYSAFHRAVRRWFGVSPHAYRQQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ7</accession>
    <name>A0A7W7WXZ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase-like HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="23680" checksum="EAC3342C94DB7F1F" modified="2021-06-02" version="1">MGMETRHVVWDWNGTLFDDNHAVLAAVNRVCRHYGSPEITIDRWRETFSRPLLQCYEGLLGRSLSDDDWAFIDVIFHEEYHAFVDACGLAEGVEALRERTSHTQSLLSMYHHDNLVPLITRHGIHDLFTRVDGLRAVGYGSKAEHLVRHLDAQGLDPAAVVLVGDVVDDAEAAEHAGTRVVLVTTGVTDRRRLEATGAPVADSIAGVLRYLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY75</accession>
    <name>A0A7W7WY75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7497" checksum="19B15E63341B9CEC" modified="2021-06-02" version="1">MTIRVHLDRLLVERGMTLTELADRVGVTVVNLSVLKNGRARAIRFSTLTALCRELDCQPGDLLSDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYJ0</accession>
    <name>A0A7W7WYJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19905" checksum="AAF550DE7CD0F926" modified="2021-06-02" version="1">MRRGGQQVDQPPADDAAAWFAGRLPDDWFTGPVDVSVDREEIVVVGELPALAEDYPDAADRSAAESGRIARFREQTREERIGIARQAERRYARKVAWGVRQGGTEELFTTLSVPVMTRLRQPERKVLDTLVAAGVARSRSEALAWAVRLVGDHADRWLADLREAMTKVDDLRAQGPDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT4</accession>
    <name>A0A7W7WYT4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="190"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="399"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="553" mass="61698" checksum="D2963A81E1FB0702" modified="2021-06-02" version="1">MTDGPLIVQSDKTLLLEVEHPLSDEARTAIAPFAELERAPEHVHTYRVTPLALWNARAAGHDAEQVVDALVRYSRYPVPQPLLVDVVDTMGRYGRLRLANHPAHGLVLSTSDRAVLEEVLRHKKIKPMFGERIDDDTVIVHPSERGRLKQLLLKVGWPAEDLAGYVDGEAHPIALREDGWQLRDYQRRAAEAFHAGGSGVVVLPCGAGKTLVGAAAMAEAEATTLILVTNTVAGRQWKRELVARTSLTEDEIGEYSGERKEIRPVTIATYQVVTRKSKGEYRHLDLFDSRDWGLIIYDEVHLLPAPVFRMTADLQSRRRLGLTATLVREDGQEGDVFSLIGPKRYDVPWRDIEAQGWIAPAECTEVRVTLTDAERLEYATAEPEERYKLCSTARTKLPVVRAVLDRHPDEPALVIGAYLDQLETLGEALDAPVVQGSTRNKEREELFDAFRRGELRILVVSKVANFSIDLPEASVAVQVSGTFGSRQEEAQRLGRLLRPKADGRQAHFYSVVARDTLDTDYAAHRQRFLAEQGYAYRIVDADDLLGPPLPEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV7</accession>
    <name>A0A7W7WYV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="589" mass="66127" checksum="71AC3912AF65E5B9" modified="2021-06-02" version="1">MILVSHSPQDREIAEKLVDALVGSEVSARLSTEGEPVFAMTQLLMVLGRGIDSRLLVQAQRVQRAGGEVIAVETGRGPESRSAPRELRTWPTVRVDPDSALSILRFVSQVRYAFVDREAVSPGSHRVGSPVEVERVAEVFAAAGRPLREVGRQLLRPGPVWVSVVSEAEYSEVEEFSKHLANYQRMAYFVHVGELPDDVRLGLDRLRVQGTPVITVRERSLRAALADQRTAAFLHELERDYGNSDNLFDTRNALVDERALFGRDVLLNTIGSALKRHENVLITGLRKIGKTSLLNILRQHLADRPVCRVDLQRFDPHTEDWPRELFALMVEAFDNWARLNDHDWPFKPSRPATVTGLERELDARQDHLGKHTQLVVILDELERVFPAPGEQEAARRWITATGGLRALAQGDRRHVVVVGADLRPEVNRVNGLDAGTNPFFAFFQEMPVSPLDHDAVKDLVHDVSRAMGIELVTVDFIENLFGHTGGHPSLVRMLAAEAYRQRAEPNALRGPDLAKGLEHLDDLDAVDSFLRNNIWQLMTPAEREVAAARIHDRPTPDFLSRRQEKEASAALKTQGLEKIGLFRRWVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ47</accession>
    <name>A0A7W7WZ47_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="11" type="ORF">F4559_006271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="819"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="906" mass="98533" checksum="90FCC027559C7700" modified="2021-06-02" version="1">MAGTTRTKKSSGGTGSRRLVIVESPAKARKIASYLGTGFVVESSKGHIRDLPRGAADVPAKYKGQSWARLGVDVDHDFEPLYVVTPDKKSTVAELKELLKDVDELYLATDGDREGEAIAWHLLDTLKPKVPVRRMVFHEITEPAILAAAANPRDLDQSLVDAQETRRILDRLYGYEVSPVLWKKVMPKLSAGRVQSVATRIVVERERERMRFVSANYWDVSATLDAGEQATPRTFGARLVAVDGTRLATGRDFGSDGRLKAGAEVRVLDEDHARAIATGLVDATLTVVSVEEKPYTRKPYAPFMTSTLQQEAGRKLRFSADRTMRTAQKLYENGYITYMRTDSTTLSETAITAARAQATELYGAQYVAKEPRQYTRKVKNAQEAHEAIRPAGEVFRTPGAVARELESDEFKLYELIWQRTIASQMADARGNTTSVRIVGTTTAGEEATFAASGRTITFAGFLKAYVETVDSEAGGESDDAESRLPQLVKDQSVLAAELSADGHSTSPPPRFTEASLIKTMEELGIGRPSTYASIISTVQDRGYVWKKGSALVPSWVAFAVVGLLENHFGRLVDYDFTAALEDELDGIAAGRQERTTWLSGFYFGGNVGPESSVGRSGGLKKLVGSSVEAIDAREVNSIPLFADADGRTVVVRVGRYGPYLEREVDGASQRANLPDDLPPDELDREIAEKLFATPQEGRSLGNDPVTGHEIVAKEGRFGPYVTEVLPDPPEGKKSPKPRTGSLFKSMSLDTVTLDDALKLLSLPRVVGTDPESGAEITAQNGRYGPYLKRGTDSRSLTGEDQLFTVTLEEALKIYAEPKKRGRAAAAPPLKEMGADPVSGKPMVVKEGRFGPYVTDGEVNASLRKTDSVEGLTDERAAELLAEKRAKGPAPKKKAPARKKAPAKSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ60</accession>
    <name>A0A7W7WZ60_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Zn-dependent protease with MMP-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13020" checksum="2D046BD6C949FD2F" modified="2021-06-02" version="1">MPVDMTRQRFEELVGEALDELPPEFAAAMDNVVVLVEDRHPDEPSLLGLYHGIALTSRNSDYGGVLPDRVTIYREAILDICADEDEVVDEVVITVVHEIAHHFGIDDERLHELGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB5</accession>
    <name>A0A7W7WZB5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="19977" checksum="E7994FA5BC798C48" modified="2021-06-02" version="1">MVAAIAVVALAGVGGGAAVGGGAGGGGPVDSLSARKADSKKSAREGNGDAAWSRLGRRVTRKVDRRDLECLTASFGQVREFFVRTPCRSLDRTVFALDDGAGNVAVVSVVWVGFANRGQVRDFQRVMDVHGSGDIRPLGSALLGLADIAFTGDHYSADPKADNITIAETESVSGVVDVGTLELIAEVAAQLPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZI8</accession>
    <name>A0A7W7WZI8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="15653" checksum="8EFE37CFAF9E684C" modified="2021-06-02" version="1">MRFTRPRDLLAVALLAGLVAHALLNWVYDTLPPLPTFAGFTLLVIAATDLALAFPLRARIRRVPGTRPVAPLTAARAVVLAKASSVLGAMMGGAWAGALLYVLPVREEFDAAGHDVVSALVGLGCAAALVGAGLWLEHCCKTPDDSRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZJ0</accession>
    <name>A0A7W7WZJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-S-isoprenylcysteine O-methyltransferase Ste14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16576" checksum="B0E6599F46DCFED0" modified="2021-06-02" version="1">MDDGYAVFLLLGVVLVLIDGQLIYRSGRGYMNRAYGDPEAAKSMTGLATVLFHLVVLGLLSIVSTFDVETGDPVKNVVVKLGVVLLLLALVHAVTMVILGRIRDRQIQQQLADEMAEEHRQFETQRAVPTQEVRAEPVVTRPEPVDPKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZV4</accession>
    <name>A0A7W7WZV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030743466" evidence="2">
        <location>
            <begin position="27"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="18153" checksum="A94709FE7DE336CD" modified="2021-06-02" version="1">MTRRPATTRFARGALLAVTSLGLTVAAHGLAGGEVVDAVPALPLTLLIAFGGTALSERLGPRSLLGALGLAQFAQHTLLSLGYHQPMTAVVDPVAMTAAHAVAAVLTGLLLTRADAALSALASAFPRLVPVLPTHPPVVGRLFVPVRSPAPDPLVGVLLRRVHGRRGPPLLPITQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXG0</accession>
    <name>A0A7W7SXG0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="90"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="31698" checksum="EA2C046BBAD9B752" modified="2021-06-02" version="1">MIAEMVRQARQSKGISTGQMVDRMGWFRSELSGVENGTRRCEVDELVLYLAMCDADRETMARVVGVHRQWGDTMLVHGHDSGLPDTMWALLNCEKAATAVAAYDPVLIPGLLQTQAYVHALLLGADVDPEKIDDRVRDRMARQQVMFEASPPRFEFFVPEAGLRAVVGSREVMSEQLMYMVLLSNRDGIDIRVLPSGISGSAWLRGQFEFMNHDEYPAVVHVELDTASVLVDDRGSVDCYRDRIRRLREAALDKARSRALMLDMAHEYKTRTVKVERLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYA6</accession>
    <name>A0A7W7SYA6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19398" checksum="ED92B8C58D54970D" modified="2021-06-02" version="1">MSLHSSAVSTLSEWVAPSAAQEALRHAYLGFLAAREDACARSCAPGHLTASSLVLDATGTRALLTLHPRIGRWVQLGGHCEPGDASLEDAALREAREESGIADLVISPTPIHLDVHPITCSLGVPTRHFDVRFLVRSLTDAPPVRSAESTDLAWWPLSAPPPDSPDLVPLFASARESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYF4</accession>
    <name>A0A7W7SYF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17531" checksum="B5884B092148801E" modified="2021-06-02" version="1">MSETTIEAGKDTPTIVIEREFAAPRAAVFRAHVDVELVKRWLGPRRLEMKVDEWNAVTGGSYRYTHVEENGEYAFYGSFHEVREDTRIVQTFTFCGMPEGVSLETLTFEDLGDGRTRLRGVSVFDSFEVRDLALSSGMEHGVVEGYERLDEVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG4</accession>
    <name>A0A7W7SYG4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="439" mass="47714" checksum="92F6AC3AB922795D" modified="2021-06-02" version="1">MTRDPFVDAVRAVGIVGVVVGHWLVTSVVATGDGFVVDSPLRWMPWLAPFTWLFQTLGLLFFAGGFAAARSRRSRLRRLVVPVGVLTGTWALVLLGMAARGVPQQTVLTVGYLVVTPLWFLAVYVVFSLVTPLSRWWWVLPVAAVGLAFEWTAVLAVWVVPWWIGVLVARHGQRRRWGSALFVSGGLAFAVCLCLGYPVSAVGVPGAAVSNLFPPTPAALALAVAQIGLVLLIRPTFRARWLTARALPVFLTHQSALLVVTLVGSAFGVLPGLHDLPDDPLWLVSRVLWLPLVAGALFVGNRGQQRRGHRDDVQRDHRRRGAQDEQRGHARQRGQQPGPAPVARAGLGGVQQVPAQQQVDQVLQRVDVQHDQGRGGAGEPGDDETQHAQHSVPDAERGREPRPVGFPGVAGGRQEPALEPVEGQQQRHEHEHQHGRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG6</accession>
    <name>A0A7W7SYG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21148" checksum="44F42C800846AEBE" modified="2021-06-02" version="1">MTARVLDTPHGPARAELHCAPEGRAGLLLGHGAGGGIDAADLVVATRAAVDVGVHVALVEQPYRVAGRRAPAPAKQLDAAWLAVAEDLGSTWFADLPLVFGGRSSGARVACRTASVGQAVAVLCLAFPVHPPGKPEKSRMPELDAVEVATLVVQGENDPFGRPETAHHRELVVLSGDHNLKADLDGLGRAVGEWLDRVLRPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX2</accession>
    <name>A0A7W7SYX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="174" mass="18981" checksum="62CEF8D15C7271D7" modified="2021-06-02" version="1">MSPVVRVVVVLVALVVGVLIGQMWPDAEPCEREEAVAAAHLSVLLARRVDGAHAVRDAVRELGAEDGVVEEFGRWAERETFRHALFGPVAVRVARRDGERVLVEVAGVWLRSADSAAGPGEVADALWSYWLVRRDGRWRPSSVPEVVTSGSVLHPASAFLRARDGFREVPRVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ09</accession>
    <name>A0A7W7SZ09_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10603" checksum="05460B47ED963DD0" modified="2021-06-02" version="1">MTGGFEAVTGEIGALAGRVEGLADRLRTAADAARTVAMDDSAYGVVCQPFAMLLQPFEDMGVQALAKAAETVSDNAAKLRETSRAYDARESGESARFGGVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC5</accession>
    <name>A0A7W7SZC5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="34364" checksum="BC5DBCC9F4BEBDF1" modified="2021-06-02" version="1">MDAVAVGANQPRQFYRGGAAIARFRGTADAAGPEDWVASTTSRFGDADAGLSRLPDGRLLRDAIAADPVPWLGPGHVAAFGDDTALLVKLLDAGQRLPVHHHPSDAFAAAHLDCRHGKTEAWVVIGTEGPDPVVYLGFREDVPPGVVERWVSEQDSAAMLAALNRFPVSPGDTVFVPAGTPHAIGAGVFIVELQQPTDFSITLEWRGFLPDADAGHLGLGYAAALRGLDRSARDVAPLVRATRGSVRTSVALFDAVADPYFRADRLHVSGHVDLDPSFAVLIVLEGTGSLGPVALRRGSTVVVPHGADAPVLTGDLVAVRCRPPVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0B0</accession>
    <name>A0A7W7T0B0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="32017" checksum="693A036251284C97" modified="2021-06-02" version="1">MNEHELRNALRNTMATSSPPPSMDPAAVVESGRKAERTRRTTVGAGVVGLVVVAIAVGTTLLPGRGADGSQVQVAASRTSDSASVTVPATPETTITEIPTTAIPSTGSSTTGRSTKPSWPDGQTDRTATSGPRADKAVGLLNELSGALPTGVRDVDKPSPDPRFPLRRPQAQFEDYVGDLQVWEYQGVTPVEKDGVAGVGRVLVQVETKGNTRLDGATGCAGATRFPYPVAAGTCEFVTVDGKQVAVVTGPAGDDQYEQAAFHWHADGTLVVVAQSRAFPHVGLTALADLPLSGTQLAALATRDGFHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G5</accession>
    <name>A0A7W7T0G5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18100" checksum="7B71D97AEFCF1AB6" modified="2021-06-02" version="1">MTDPSGRRAELEARNAAMREQVDTLLGELREKTAQLRETQERALAVTASAVSKDGTVKASVDASGALTSLEFAPSAFDRHQTPDKLARLATETVRQAIAKARTEVEETLADARTGPSLDLSELLPGVPPLSELVPKPPVVADPPATTRRPAPRDDDQEGESFMDRSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L1</accession>
    <name>A0A7W7T0L1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="120" mass="13006" checksum="03D760AE752DDCDA" modified="2021-06-02" version="1">MTNGSTSGLVVTEDELPAPGESVEINRGKFVVTVENTDQADVVDAAGFGAVVFYTPVETVHPSTKRHAAAVRQRNVRTRVESATLCSRAGTRRVKRRLHEPLTNVTCVQCRSILAEEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S3</accession>
    <name>A0A7W7T0S3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="14918" checksum="4726062B7D9E075B" modified="2021-06-02" version="1">MTTPAVEGLDNFSWLVDDFVSRVAGVAHAIVVSADGLLLASSTRLPLDRAEQLAAVASGLVSLNLGAARCFEAGDVRQTVVEMERGYLFLMSISDGSCLAVLAAPNCDIGLIGYAMTRLVERVGVQLTPEIRSQLHVAMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y1</accession>
    <name>A0A7W7T0Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="20198" checksum="78070D99C96FB45D" modified="2021-06-02" version="1">MPFFDVPERKQGFEELTAWDPSSRSAPREWVLPATVPWTARLGEGRSAVVVLDQVRCWREGVEFTLLAFRRRVPFSGNRLSIEATLRFGVGFADGRRATTVDPWDLPDDRPALVPQGGGGSQFHQRKDYYLTPMPPAGPLTLVVAWPDGDIPETATVFDAAELRDASDRAVAIWPDLVPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T113</accession>
    <name>A0A7W7T113_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15296" checksum="27FE4F016B120894" modified="2021-06-02" version="1">MGIPSRGAPLAVRLGGLIGEFSGREVPVGTLDITLYRDDLRRGPTRPLAATKVPDGGIDDRLVVLVDDVLFSGRTIRAALDALRDLGRPRAVQLAVLVDRGHRELPIRADYVGKNVPTARSEEVHVLLREFDDRDGVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T114</accession>
    <name>A0A7W7T114_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">F4559_001957</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="47"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="319"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="427" mass="44387" checksum="A1B5001FC880C15D" modified="2021-06-02" version="1">MTTLVLKGVRPYGEGDPVDVLVRDGVIAAIGTVDGADAEIVDGAGAILLPGFVDLHTHLREPGREDTETIATGSAAAALGGYTAVFAMANTDPVADNAVVVGHVARRGREVGLVDVHPVGAVTVGLKGERLAELGTMARTGVRVFSDDGHCVHDPLIMRRALEYSKALGVVIAQHAEEPRLTVGAQAHEGEHAARLGLAGWPAAAEESIVARDCLLALHAGAKLHVCHVSTAGTADVLAWAKARGTTVSAEVTPHHLLLTDERLDSYDPVNKVNPPLRTAADVEKLRLALADGTIDCVATDHAPHAVQDKDCEWSAARPGMLGLQTALSIVVETMVATGLLDWRGVARVLSERPAAIAGLADQGRPIAVGEPANLALVDPDARWTVRGAELASIAANTPFEGMELPARVVATVLRGKVTARDGQVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B0</accession>
    <name>A0A7W7T1B0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="52" mass="5618" checksum="166D960BBEB7A402" modified="2021-06-02" version="1">MTGSPREPTLDELIDDEDAKIAALGEADGVRPALDPEDPLEEEYGHRPVDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T208</accession>
    <name>A0A7W7T208_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system Cascade subunit CasD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010147">
        <property type="entry name" value="CRISPR-assoc_prot_CasD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01868">
        <property type="entry name" value="casD_Cas5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26449" checksum="4D7CBFE5BBC631B8" modified="2021-06-02" version="1">MTTLLLRLGAPLQSWGTGSRFVRRNTDRAPSRSGVLGLLAAAKGLRRTDPLEELLGLRIGVRVDQVGSLERDFQTARTRDGKNAMPLSYRFYLADAVFAVAIEGDEALLVGLRDALRAPVFPLYLGRRSCPPAGKLLHDLADGTVAERLAGTPWMASPWVQERHRHADVTLDTVVDCTEDEPGVELVQDEPISFDPRHRRYGWRSVRHRPVTIANPAYKPALPDPASDPHCPMAAFEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T219</accession>
    <name>A0A7W7T219_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system Cascade subunit CasA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013381">
        <property type="entry name" value="CRISPR-assoc_prot_Cse1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09481">
        <property type="entry name" value="CRISPR_Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02547">
        <property type="entry name" value="casA_cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="547" mass="59740" checksum="B72C34C06C5329BD" modified="2021-06-02" version="1">MSAGDRVAFDLVDQPWLIARTLDGEPVELSLTEVFARAHDLAVLAGDVPTQVFASTRLLLAVLHDALRGPEDMDAWEELWTAPRLPIDTIADYLAEHRGRFDLFHPETPFLQVAGLRTAKDETTDLSRLIADVPNNAPFFSTRMGRPLVLSFAEAARWVVHCHAFDPSGIKSGAVGDPRVKGGRGYPIGTGWSGNLGAVLPEGRTLRETLLLNLMPYEHGLMQQRDPDQDVPAWRRPPAGPAEDMEGGRPPTGPLDLYTWQSRRVRLVHDDAHVTSVLICNGDRITPQNKNIFESHTAWRRSKAQEAKLRSGVVYMPKTHEPQRAVWRGLQSLLPGAAKPQSNEAAAYLTPDILEWVAEVRGVIGEAYPVRLRTIGMTYGSNNSVTDEVVDDALSMKAVLLGRGVAELPDMAVRCVQAAEKAAWAVGKLAERLADAAGCGKDELEGPRTRATESAYALLDPLFRAWLETLGADTVATDAETAWHDRARAGLLPLVRNLLAAAPAKALKGRVGNEKRFVNSPLAQGWFFGDLGKALHRTSEQEGEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T234</accession>
    <name>A0A7W7T234_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030775116" evidence="1">
        <location>
            <begin position="27"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="25534" checksum="3D51CA5FD484E16C" modified="2021-06-02" version="1">MPFRRSVVVAAVFATTFAGVATPAFAATPYPSTLTATVAPASIDGGQTSTLSGRLTITTPSGERPLANQTIRARFDAWNGFGGTEFPKTDANGYYTVAAKPVSSGSWRVGYDGWPHEPGFPGADPAAAYPEYVNVQQLTDTFLVDTGRTTTGNVYVRGGLSVPSKYLPYDHTVYVRIEYSPDGVAWTTKATVGATPFHNGSYIYNTGAAEPAAGHWRAVHDGIVGRTKASTSGSRFVDALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2J4</accession>
    <name>A0A7W7T2J4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043764">
        <property type="entry name" value="DUF5710"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18974">
        <property type="entry name" value="DUF5710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="972" mass="106291" checksum="6C93111BD9DB8C7A" modified="2021-06-02" version="1">MSAEAVGDQPEVAELLRAVRAEIDATLGAETGFDKVVLTEGRVVGGGGDRHEYSFAARGWKDSSAARPLLIRARPRTAWESAELVVAERGRLRLRTSAVLGAKAELREDDTSGLVALAEQLDRTISGAGGLNLTAAGWLVGRDLPAAGRCPHPERYVRGWRSLQLNDRQRDAVARALGSDLTFVWGPPGTGKTEVVGHVVEGNHRQGHRVLFLAPTNVAVDQAVERLCELLSAEDGFAGGLVQRAGDIAPGSLKEKYGDRIEQRKIVARLSAGLTAEIGELRERLDVVDSRLALHREHAELLGSLEQLRGDARRATRDVATAAAECERARQEAARLRAELIAIGVPTGPSAARKARQQEELLSRLQVVDQDVADLVARHLLATAEQRRHAARVQAAERKASALRTTLVGSADQLATTAKNLRERLEDRQDKLRAVEVEVRGNCRVLATTVAKAVQSRYLIDRFDTVVLDEAGMVALPAAWYAAALARKRVVVAGDFRQLPAVTRASGDHDADPATRAHSAHWMDRDAFHAAGLVDGRGRVRPHGCLIGLDTQYRMRPAICAVVNTIAYPDAPLTTGRADGSRLPPSPLLESPLVLVDTATRRSAAQGGPRSNPVHEAVIHELVRGLQYDGVLPARKEDGGPGDRMAVIAPYRDQVGALKGSLAYRFGADYDGVVDTVHRFQGSQRPLVVIDTVAGAGDRVGRFYEGTGLSSATCRLLNVAVSRAQDHLVVVADVDFLSRNLKPHGEAARLVDHLRRHAHHLDVGDLVPFRAADDLAGLDPHELTRPAFFPADEVPRAVAWDFAHARRGIDIYCAFLDADPVERWLAKLTPRIEDGLTVTVHTRPARRSDDERQIARLEAAGCTVVRRERMHEKVVIVDDEVLWHGSLNLLARTGPTDLMMRITDPGACERVRRIVERARAEPGPKAGGRLYLNVPFAENDLARQTAKARWDPKSRRWYVPHDTPRHLVERWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2R2</accession>
    <name>A0A7W7T2R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="228" mass="24713" checksum="A7CBACDB2EFC719C" modified="2021-06-02" version="1">MRRTWSVVGPVVKALLVVAVCVGPQYGAALLLALEWGLRWAHTLVALSLMVGGVVVIGPITRSAVRAAGVEDAMDFSAGIAARSVSGVLLFVCALQSLDAAPAPVRTLETCTSVRSYIVVEEIDRPEEAKYFDLVRPSGRTLAARGKLHYEVGRTWVVEFDPNDPEPYTDPVFLWSARTSWTIMAVCAALIGVDVLWLGLCARRVARPRDTPPSAEFRLQDFRPPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2T9</accession>
    <name>A0A7W7T2T9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35069" checksum="1F7BFD669B1933D9" modified="2021-06-02" version="1">MDDVVLGSVTCPSGHLVLVDGGYLGLWSGERSPDETGEPAAVDFEVVGPDADAAARSFDRQTGRRLYDIPERTAGGFAAKFDEHCRAHGLDASSHRFPRRVPHRERVRHAVETGDTHFLISGVRVVPIGGVPTDRPLRVVATRGHWGWARIRIEVGDGTAVERRPLTRLGVDHARFAFADADALGSWVHEASLDGLADVMFWGRDEEEIAAEFGARRTGTPGDDVYAWLDIPIREAYRRAVALQELRSAEPERGFAFDFRPHSHHWQVMAAVRAADHEAATITIGGADIMMAMTSIGDGHFPVDLDLDATGAPVAVDITVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2V8</accession>
    <name>A0A7W7T2V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="519" mass="56230" checksum="74A83457FAFE79CB" modified="2021-06-02" version="1">MTKKSRHGGTEAPPRPESLLPVGTVYDGELPDRLRRAYGTTDIGVWSVAFDAYNNVVDIGTGKPWADGDVDDLAIGALEQTAAQCQKWAADRTEDQDREALRTYEEAAASAAGALDWIEHTDTVLDEVVDGTEGATTARRLISDHERDQVLATQREADGDTRHRKHRIEHVWVVIAAFVLALLDVFLLWKPLLGLGFQGSSDMLLKWVIGTAFAVGQALFIERALHVYTQAERDDVDRRDAVRDYNRELRRGALNPQDPGLDGVAEADRKLRTACRWLLAAALCTAVVAAVRVALLAGATGLPAVEGAVFASVVGLVLGGLVVLLGMAGARGNLLGDRLRWGRSVVAEVDGRVQEGRDKVAERREEARRHLLRADLIAAEATGRRHDIIAGYHQAMLLACSWSGADRKVLRRLEIEPRSLPVADHSKTLCRTVNGKLEAVDAWLANRPSPLPMAHSQAPLALPSGKFRLPAVRPGAGVVRYGAQHELPEEPGISPWLLAGSALVVVVAAVVAAYFAPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3A8</accession>
    <name>A0A7W7T3A8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Decarbamoylnovobiocin carbamoyltransferase/7-O-carbamoyltransferase</fullName>
            <ecNumber evidence="4">2.1.3.-</ecNumber>
            <ecNumber evidence="4">2.1.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NodU/CmcH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.-" evidence="4"/>
    <dbReference type="EC" id="2.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031730">
        <property type="entry name" value="Carbam_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038152">
        <property type="entry name" value="Carbam_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003696">
        <property type="entry name" value="Carbtransf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16861">
        <property type="entry name" value="Carbam_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02543">
        <property type="entry name" value="Carbam_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_N" evidence="2">
        <location>
            <begin position="120"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Carbam_trans_C" evidence="3">
        <location>
            <begin position="386"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="646" mass="70290" checksum="4AF6734934162A18" modified="2021-06-02" version="1">MLTLGISGHFDLLPALHRAYMHDAAACLVADGELVAAVEEERFNRIKKTNRFPTGAIRACLDVVGARPSDVDAVGYYFNRDMVELGLRTFQLTAPATPVRTGADLIRDRLRADFDWAPDHLVFTEHHEAHAWSSFARSGMSDALVVVADGRGEHVSTTVYLAGGGGLRELRSYPVRKSLGLFYQDAIGHVGYGFGDEYKVMGLAPYGDPARYRDVFGSLFTLLPDGDYDLTASMPDMNPVAAAFLDFPARRTGSPVTQEHRDFAAGLQETLEVIALHVLTHWARATGAQRLCFTGGVAHNSSLNGLILRSGLFEEVFVHPSSHDAGAAEGAAIIAARDLGTPHTRVEPLRSASLGPSLGTDVERELLAWQGIVDVERPADVVAATAELLASGAVVGWARGRSEFGPRSLGNRSILADARPVENRDRINAMVKKREGFRPFAPAVPAEAAATYFDLTATSANHAFMSFVVHVHEDRRAELGAVTHVDGTARVQVVSRDANPDFHRLITAFGDLTGTPVLLNTSFNNNAEPIVQSVDDALTCFLTTDIDVLVVADFLVRRRTFAVDDLVPAFRPDTRLRRDWRPGEDVPAEIYLDHSHGPSAPLSPALFDLLNAVDGKSTLAELGEVTDEVRDGVLDLWQRRLITLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E9</accession>
    <name>A0A7W7T3E9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11847" checksum="04B8A590EADE1252" modified="2021-06-02" version="1">MKAMSEQTFLILTALADESRHGYAIVRAVEELSDGRTTLRVGTLYGVLDRLVADGWADRGREEVHQGRLRRYYKLTDAGVRALSAEVARLSANVRAASAVLNRKGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I8</accession>
    <name>A0A7W7T3I8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15011" checksum="2C0AE4AC791FBE8D" modified="2021-06-02" version="1">MTTPVRASDTERDQVAARLRDAVGEGRLTLTEADERLSAAYAAVHRDDLDTLVADLPGPPPAPPRRRPPIGAVAAFAVAFAVVGWVAGPPFPLLVVLAFVLVRRRAGKPGSALGFGHGPHRRVLRGRRAPGRTGALGHRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J6</accession>
    <name>A0A7W7T3J6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-L-isoaspartate O-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027573">
        <property type="entry name" value="Methyltran_FxLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04364">
        <property type="entry name" value="methyltran_FxLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="45608" checksum="5E31D0CDE663AEF1" modified="2021-06-02" version="1">MNTLRHDEANVSEARDALVDKLLTRRMITSPAVERAFRTVPRHLFVAEGTPLDLTYNVDNPVAIKRDPDGVIISSTSAAYIQARMIEQAELGPGMSVLEIGSGGYNAALLAEIVGPDGRVVSVDIDQEVTDRAGELLDATGYGSRVAVVQADAENPLPGLHEPFDAILVTVGAWDLAPAWLEHLSADGRIVVPLRMNGITRAIGFRREGDHLVSTSAEVAGFVAMQGEGARDERVFLLPDRHGRHVKLRFEGDVPQGMSLLDGVLATDRGEVWSGVTINHGVSFADLHLWLAAFLPGFCKLAVDEGTDMAAERKSWFPFGVVRGDSFAYLAVRPLSAGGGVEFGARAYGPHGGEAAVTAMVEQIQAWDRKARTVEPAFAYWPAGSQPPESGEYTAVLVKAHGLVTISWPPTADAAAGQVAPHNPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q3</accession>
    <name>A0A7W7T3Q3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="226"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="953" mass="107309" checksum="B9AE3A981FDB616D" modified="2021-06-02" version="1">MARVYVSSTYSDLQEHREAVRTAIRRMGHEDVAMEYYVAEDTRPLNRCLEDVRASDVYVVIMAWRYGFIPEGHSESITELEYRAAIDAKIPVLAFVLSEDQPWLPKLVEHSKQVDRFRTELMNSHLVGLFTTTDDLARRVAESLHVRPADATVDWDVYRQAVVDRYEFVRLSVIAGTRDRKPARIPLTEVFVPQQLLPGRPEYDVPEDEEVEAVPADAVRVVGATPRQVLLGGPGSGKSTLLHATMLTLCHPSAPPPGQGLADLPVPFLVELRRYALSGADDFVAYLENTVQDELGVRLGSEAIVDLLSSGGAVVLFDGLDEIVEPTARARAVDRFRTFTTRFPDARVIVSSRIVGYDDTELGLAGFDHHTLLDFGLREITEFVPRWYRHYTVENDDRDAAGLIRRITENPRLRELAGNPLLLTMMAIIYKHQDLPEKRWQLYARCTAVLLEDWDVKRKKIDTRETLRLDFPIGADQKAEMLQRVAVRMLADAHSGEVNAIPYGPLRATIADYLTSQYAKAPAEARALSTEIINHLRERTHILAETGDGVFGFVHRTFMEYFAAGHVLGEFNHRKADYDWLKVDVFGARRNDDGWREPLLLLIGMLSGQGSPVREIVESLLRHNDALLFAADCLAETGQVAAADQRWASGLLDKLVETVRDRPKRMPASFIKDIVASFCRLATFVPMSHRTPFLTEELSQSRSTNSQAAGWEMSLAFSTNDERRHEAIESLHSGSSAVRRSAVAMLARDWPGDEEVYDHLIGTLETDGSATVCENVLNVVAKNWPMRRESLLPIHLAVSILGIYRIAEHLSVEWKGNIEALMVLVYTTEHGIHLGDFDFYLTIARRLRSGWGHLDDANSFLNDIAKNSKNINSALASAIALYLADHQLHDTSEQLHKLSEDALEIELSRRSELISAFIAWIEDFPFSNRSIRTQIKLVASHDIQTARLRLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U4</accession>
    <name>A0A7W7T3U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="43896" checksum="2B3E5298CF1B4884" modified="2021-06-02" version="1">MNVEDNHIGRRLREVRSWRRLSLTAVAGLAGITPAYLSMIERGLRPVTKRAVLEALATALQVAPTELTGSPFAPTDANGAEAHATLHEVETVLSAVELGVDPGVRVASWPELRDRVIHLNTVLRPEADYAEQGRVVPGLLLQLHAAYVHHPAHRRDVLVGLLHTYHAAAVLTKNSGVRGLPVLAARLARECAQELNSPEWLGFSVWLRGHAAGSQGRAHQLTASVREIDRLAGVGGPNVLQARGMLHLNAALAAATLRDAETARVHLDEAAVLAVHLPEGRDNFAFLHFGRPNVGVWRVSLATELGERGKVAELARRVNPDVLPAKARRAMYWTDLGRSLLTERSTVDKGIQALVTAESIAPQRVRNNVFVREAVADLLRRAQRDSAGRELRGLAWRMGVAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W4</accession>
    <name>A0A7W7T3W4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32910" checksum="D562AB4BB68766D9" modified="2021-06-02" version="1">MNAAEHESDPAADAVTVFHRAVARLFTVHDVATRPEVLQALESGRLARFATYAEWLFDLPLTTDESQRIRSLYDHCLISERPRRHDGRRPASKQEATADHDAVVDRRARDRAPTRTDHVPRPSLVIQAYTEESLYVRVKQPLDVDVHKASTALDSGTALEPMLDTELQATNAAEFADLLGLIQLRSGLTPPRIARASGIARSQVYSMLRRGTLPTRQDQVVQFLRVCGLPHHQIMRIVRLWLELRGHARQPSPKADSPADRTLAELTRVLSDMIDKACAGESADLGLVITEPSDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3X1</accession>
    <name>A0A7W7T3X1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="292"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="38464" checksum="67856BEBEC90547D" modified="2021-06-02" version="1">MAVDAYQREIPDFRRIATRPDVRESLLDFAVYLRRRTIELIADDEPFSRADIGLITAMGRARGAKGVSPASQRQVLVLHTSLLLREVHEIAGPDDGDAVMSALHWLPELGAASHSAYTTGYLGGLADARPLVDRVLLLAEALVTDDPLAHDLAAHLAMPVPRRCLVVVVRLPRSDVPRSAVADLLARHWVPCGWTAADELTAVVDGRDRGLAFVRDFVAAVDVPCSIGAAHGEVGALSEVAAGAREVSRVAPPRTAIHLRDDLFAELGVSRVPAVDAWLRDVADRLARGPRLVGTLDAFYRNDMARSRTAAALGVHPRTLDYRLRRVEELTGIDPVTVRGVRILSTAVNRVLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T446</accession>
    <name>A0A7W7T446_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="809"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="871" mass="92652" checksum="F6DC66F24D840007" modified="2021-06-02" version="1">MDTLRHNRLVDRETHLARIAELAAYARAGSGGLLRLVGGSGVGRSALLAEAARRAALGGLTVLRARCAVDETATSYAAARQLFGLDPNGDGTEAELWSLLRLHCAHDTLLLAVDDVGLADPESQRWLVRVARRVDRLPVLLLVTERREPGLGQTPSAFARDLPVELAATCRVAPLDRRAAATLAPLADACFPATAGNPALLTALLADLEPGAAELPTVPGETFTDAVGRWLRGCGARAETAAGIVALLQDRPVADPDDPAALIAAYCAADVDHVTGWFADLAARGLLVHDRPGHWPRFAHPLLTRAVLAGLAPGQRAEIHRAAARFRHRNGEPDDRVAAHLLHTAAPGPAWAAHTLVSAARTASPADAVVLLRRALDEPLGEHRRGLVLGELGGLEVVTDDAERGIRHLVEAVHLQQSVDGLFRAANTLGTVLAARGETPAALDVMADLAERFADRPDLVHAVEAAAALIASHDGRSWLEVVRGLRRIAVGTPHDLAPPAFALLTEFDATNGVLSAAEVADRVHALVAGPLDPAVRPYVLVSAATLAQWADLLGDAERLVERGLAAFREPTLEPAYQCLLSVRAETRIMRGEYAELLAESSGRNPHLVAQTVIALIETGRPERAHELVAGVDDDRDSWEWNEFLYARGLLRLASGSPAEALADLRECGRRQAEREVHSPVVTPWRSAAAECHVLLGEPGPAVALAEEELRLARIWGTPRAVGRALRALASATGGRRGLSLAADAVDLLREPAVPELVPALITHGRLLADNGRRITARRVLRDAATRAGRAGAVRLRGVAEAALRDLGARGARPETLTDSEERICRLAAAGHSNTEIAELLHLAVRTVETHLTNSYRKLGVRRRSGLAAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T485</accession>
    <name>A0A7W7T485_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="43554" checksum="14F1E30BA0A5D61C" modified="2021-06-02" version="1">MTVPLFDVADWPPARLADPYPVYRRYREHDPVHRGVADTWYLFRHDDVVRVLTDDGFGRSAHAVRAPDGGTVPPIPPDYDRLRRVVANWLVFLDPPRHRRLRALVSRAFTADTVHALRPRIAEIARGLVRAMRDRPVVDLVEEFAAPLPILVIAELLGVPAHDAPWFRERAVALQEAGGTRTSRRADAYALAEEAAGQLADYFLRGHDRGLVALLARAGLTEDEFTGTCVHLLTAGHETTTNLIGKSVLALLANPSALDGRRAPTTGEVDELIRYDAPVQMVTRWAYRDTVLRGRGIHRGDKVVAVLGSANRDPCRFPDPDVLRLDRTGPAHRGFGMGIHYCLGAALARAEAEIGLGALLAGNLLAGSAFDVRYGADLVFHGPTRLMLRTTPQEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4B8</accession>
    <name>A0A7W7T4B8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent protease with chaperone function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="136"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="640" mass="66677" checksum="54B168507F7AA0D8" modified="2021-06-02" version="1">MNRPRPDAAWGRYALLILVPVLAACAAGELVYFVLCEEEYGAALKACMAQARAAAPDDVFERSRFFAHCRIPVELGKAGFVVAAGAVAVVGGVVLLRLLPRRLYRRAGRMRVAGERWQSAAAGAVRSLGGSVLPVVMIAADCREAFTVRTGGRVRIVLPRAVVTLPDDQALALLRHECAHVVAGDVRRVWLTRGVWWAAPVLFAAPVAVRVLEDDDPTPDSGDWVLRVVCSALLLTLLWVVARSVLRSREHAADLRAAGGAAERAALCGLLARGAGEDRTSGARRWAALHPSIDRRLAVVEAGVAVPTRWIDGLAIGALATCMMATTTWFLRPVLPGLELGGWGSLVAALVPGVVLGVAWGALSWETPAFLPWWRRMAAVLGLAAGVLVGLLLAPTALTMLVGDLPYFLNTWWLTALMVAGAGALTGTLGALIGNAPPAARWWASVTAAAVWVGAIAPIDVIATVIGEGGPLVGLAVAADMPSWAMLVGQGSIAVVAIWRCPGRPVAAVVTVGLAAAVVVTSLLSTDPLVGELTTERIVTDCTIAAGAGVAAAVLALVLRVDFGLAMAAAWGVTVLVAAGLAVVLGFAVDDALRFSLLPALNLLMIGLLALAAVTVPVSRPDPRVRVVPRSVLEPVEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q3</accession>
    <name>A0A7W7T4Q3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13231" checksum="430394CF5A1C8CD7" modified="2021-06-02" version="1">MKVTKDLVAASATPMVLGILAVEDSYGYAILKRINELSGGELEWTEGLLYPLLHRLERLGHVESDWRSVAGERRRKYYRITPDGLAELAEQRRQWETVVDTLKGIWPGPITIPLGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R7</accession>
    <name>A0A7W7T4R7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YbjT (DUF2867 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="281" mass="29975" checksum="F2E657C65DBBFBB0" modified="2021-06-02" version="1">MTTGEATTVLVCGATGNVGRPLVERLLAEGHRVRALTRDPARAGLPVGAEVARGDLTDTASLVEVFAGVTAAHLIGFGGDHAPLRNGPELVALATKAGVRKVTVLKGEAETTGLDRAVAAADWDHTFLSPVEFMSNSLEWATQIRETGQIVDGFADVKSAMVHEADIASVAATVLTTDGHAGKEYWLTGPEALTARDRLAAIAAVLGRDIPFVELGRDEIVARWRAQGHGDEDIEFFLAMRTTPPEVAYTPLPTVEQVTGHPPRTYDQWVRAHETLFSPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U9</accession>
    <name>A0A7W7T4U9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma regulatory factor (Ser/Thr protein kinase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14293" checksum="8E4488FCB8092872" modified="2021-06-02" version="1">MLLEEPPDTGETGTTALDLAVDGANLAGMRRHVAARLDGLAEDLVQDVELVCTELAANACDHAEGPHRLVLHRQDTQILVEVHDGSPHREPTVGSSTLGPHRGHGMRMVESLCRAWGVRRGAAGKTVWAVVPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4W6</accession>
    <name>A0A7W7T4W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18347" checksum="A092F422B553890F" modified="2021-06-02" version="1">MSPSPIGRLLRVGGGADLILTRTFRAHAEDVWASVTESERTARWFGPWEGEAGPGRVIRVRMAYEEQEPWCEVRIEVCEPPLRLVLSVVDGDSTWPLELRLSEVDGLTTLELVHHLPDTTGIGEIGPGWEYYLDMLVASRTGSARPVFDDYYPARKEYFEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T557</accession>
    <name>A0A7W7T557_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="47354" checksum="2E47BC240D46DDD6" modified="2021-06-02" version="1">MTVPDDATTGQLLFSSQLGVFHRRIDTENTPGSLHGMFARQVLGDGTSIRWRVEPDLDAWLRTNVSRLEDAPALAVLGYVATAQPTRLPVFADVLVHGLEGLAGRDPYPGDRVTPLYSAGIVLGLHLAARAVQDRVPQFLTWLRKALSHPMREPNDPWLDLMHQHVLAELTGEPASLPVLAGLADHALVAAFYLLASGTGVARDTPEELRAAQHRAMHVFLRTDPAHLEVRHAALWLNFAEAVATASADQLVISVPQVSQVLRRFPPAMKRWVWDSAERKDPKWWRVDAEREVQAILWIMLRAVFDDVVDEENLPKLGHSAYRADFALPSLGLFIEVKFVRSKSDFKDVEQEVIIDSIGYLKDNERYREIIVFIYDDSCSTEHHDETRRALIDLPGIADVIIVSRPGVLPPADERKAVLSPGAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G6</accession>
    <name>A0A7W7T5G6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004265</name>
        <name evidence="3" type="ORF">F4559_004840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15910" checksum="6780A365019A00DA" modified="2021-06-02" version="1">MSSPSDKQSRPSRDDQADPAPRPSRRVFTPDYKLAVVTEYENAPAGEKGAILRREGLYSSHIIEWTRARDAGRLTGQAAEPGAQTKPARKSAEQVELERLRRQNEKLASDLAKTRMALDIMGKAHALLEELSGSAEDDTPPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J7</accession>
    <name>A0A7W7T5J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="23139" checksum="AD4BE92419381545" modified="2021-06-02" version="1">MDERFRSWAADEDEVRHRRRHAERLTGQHIVAVRYYDIDYRREEFAPDASGPRTVDDETEWANPTWRYPGFDAVDFAVELETAAGEVYTLTWDLPGHWESLGIHNAPAIGEVVSTEASVAIWNVGDRTKTWAPMTRTPLTGIDLHYHPWPAPVGGFWCSRITLHTATTTLHIVLGDAGRDGLTSSADNLAILHPTTPIPNWPTALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K1</accession>
    <name>A0A7W7T5K1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="353" mass="38156" checksum="AD8C38A48E253FFC" modified="2021-06-02" version="1">MPDLPARPNLTQLRHQAKDLLHAAQRGERDALARIRTVSDRVILASAQLATAREHGFSSWAKLKLEVDRRDILNYRDLSRLAALLAEHPESAATKMEHWSDHPEGADLLGYLATLRFDHRRLGLPHDLSGTGAVARTLIDAGAPVDGRPGDKETPLITAASYGDAEVAKVLIEAGADIDAVSAPDSGGVPGSTALKHAAVFGMTEVLDLLVAAGTRIDSLEMAAAAGDIGDWPLHRSPLQSRLRALVFAADHQRLEVIDQLVAAGTPVNQADAEWQRLPLHIAARNGRPASVRRLLAHGADPDLRDPRHHRTPLQWCRPENRDLDSPGHEEVDALLRPLTRHQAAPTSPSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R4</accession>
    <name>A0A7W7T5R4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="31026" checksum="0F55601307A8BA47" modified="2021-06-02" version="1">MSTSGPGRGRDDLGRALLAQHPRGEQWRQLDVTIANLTFDQITRMGSLGEEHASDRQAVRDRIIAGITDPELAGRLASRWIRWKDTFGLPMPAELDDPIAVLHHPYVLARQAAPNHSGWHKVVLPVFDAGLAIAAAGHDDEGVADYELLTAPWRQTCLPSRYTATSAYGPRSQAALRVLRHAEVTSATVVRRMGRACAAIDEQHWEAACAAVTEASIAWGFPLRARCLYWETVPAAEDAVGESPTDTSIVNALWGAAISQAFAGRLDSDTSALLASPWRTAGLPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Y0</accession>
    <name>A0A7W7T5Y0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030859938" evidence="2">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="375" mass="38784" checksum="D2F9850B43E06215" modified="2021-06-02" version="1">MSVPTRRAGLAMVVLLGVSACGGEPTVGTPVSSSGVSPAAPSSAASSAWKRQPEIKVDDARFGFGDRVGDEIWVSGTAKGAAVVFVFDAETRELKETVTKSKNSLAAADNVNAIAVTASAVFLDTGAGNLHGIDRATHEVAVYRQLPAAKDGAKPGKPVSTRDGKAAYVAVGETVYELDKADGTPVRTFTLSNPGVTVPSGSTTDYRLLGVAGGLVWYGAVVKTTPLSGPPVYDRLLTLDPASGAVKPFQVKADGTILGPETVGDKVVFSYLNTLWVVDPRSGEARELPKTRLAARAEASSLKDVDGLSTYGDEVALIDEGLIELVDLGGGASTLVPSECDVPKPEFGACVYGDVVMADDSLWAITPSALVVFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T686</accession>
    <name>A0A7W7T686_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YdeI (YjbR/CyaY-like superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21263" checksum="3C4AF9D85E083C88" modified="2021-06-02" version="1">MADTALRCETIEEFTDWMEANHESSTEVWVALPKKGTPVPSITRSEALDVALCYGWIDGKAYSGDVPDGWWAQRFSPRRKRSPWSKINCGRVEELIAEGRMRPPGLAQVDQAKEDGRWGAAYAPQSTAEVPADLRAALDASPVAAERFDALSRSNRYQILLNVEKAVKPETRARRIANYVLKLASDGPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6A6</accession>
    <name>A0A7W7T6A6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="32" mass="3363" checksum="3AAA8E5E7611CA2E" modified="2021-06-02" version="1">MTAGPGVRMSLLANDPPTSGREAHDRGVRPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X3</accession>
    <name>A0A7W7T6X3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025141">
        <property type="entry name" value="DUF4082"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13313">
        <property type="entry name" value="DUF4082"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031281805" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="5">
        <location>
            <begin position="630"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="785"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="5">
        <location>
            <begin position="901"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="5">
        <location>
            <begin position="1173"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="4">
        <location>
            <begin position="1326"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4082" evidence="5">
        <location>
            <begin position="1441"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1592" mass="169145" checksum="357B9D3DF617BA38" modified="2021-06-02" version="1">MLLVTGVVTPLVVLSAATAEAAPCDTPVVNKVACENTKPGTPDWQVSSRDDSIVGYTTDISTTPGGQVAFKMNTDATAYTIDIFRLGWYAGVGARFMGSVTRNGAQNQPQCLRDVPTALIDCGNWSTSVTWNVPADAVSGIYYARVTRADNGLKNEIVFVVRDDTSHAKVFFQTSDATWVAYNRYGGNSLYFGDGPGQGGQAYKVSYNRPYTGGDGDENFIFNAEYPMLRFLEANGYDLSYTTDADSARRGHLIKNHQVFMAVGHDEYWSNEQRANVEAARDAGVHLAFLTGNEIFWKTRWEKSIDSSQTDWRTVACFKETKGTQDDNLNDWTGTWRDPRKSPPEDGGRPENALLGNIFTVNGRRDDRLAVPAEYGKMRLWRHTSLQNMAAGTTYQFEPGTLGYEWNTVEDNGFQPAGVGQFSRTTVAMLDGPYVLQNYGDYYTPDTKTHAITYYRHPSGSLVFGAGTVQWAWGVDDEHAFLTNTPTSDIRIKQATVNFLADMGVSATTLQAGLVQATATTDHTAPVVTYNSVPALSTVGAPYTFSGTVNDAAGRVTGVEVSTDGGNRWHPAVWQAGQANWSYTYTPSASGNAQLRVRAVDDSLNLSSPVSATPGVSARTCPCGLFTTNDTPKTPEIVDSGALELGVKWRAATDGYVRGIRFYKGPGNTGTHTGTLWNRDGLLLATGTFVNESTSGWQTLTFPIPVAVTANTTYIASYLSPTGHFSVDTEYFSRSSRYLEPLTGLQTGVDGPNGVFRAGAGFPDRSSQDSNYWVDVVWASDPGPDTRAPELVSTDPLASGGSVGLTPTLTAKYDETLNPGSAVFTLTGPGGPVTGTTSLAESNKVVKFVPGSTLAPNTTYTAAVKAKDAAGNEATLYNWTFKTGANRPATCPCTVWDDFKTPETAGAADDSAVEVGTKFRFNGKGEVLGIRFYKGPGNTGTHTGTLWSAAGLPLATGTFVNESASGWQTLTFSSPVIVQANTTYVVSYYAPKGHYAVTPGYFDTNGTVTYGAIRALGNGVDGGNGVYRYGTGGQMPTASYNGGNYWVDVVYRNGLNGDTTPPALVSRTPGDDATNVSLNGTVTFTFNEPMDPAATQIAVTDQGGAQLTGNAALSADQKTVTWTPSAPLKPNTKYSVDALLADANGNAMSAPAKWSFTTTTTAACPCTLFSAATVPTTTAADDGGAYELGVRFVPKQSGQITGIRFYKGTTNIGTHTGTLWTANGTPIATGTFVNESASGWQTLTFASPVTVAPNTTYVASYYAPNGHYAIDHEYFYKTAVTAEPLTAPKTSDLTLNGVFQPGGGFPQMSHQGNNYWVDVVYTPSADTTPPVSSGHTPLTDATDVSRTTQVTATFDEAVDPVNTQFTVTDRGGARIGGSVARSADKMTLTWTSNAPLTAATQYNVRVLAADLGGNLMTSALEWKFTTVTTQTCPCSLFSAATVPTVEAADDSGSYELGVRFTPSVSGFVTGVKFHKGTGNSGTHTGTIWNLDGQALKTGTFSGESATGWQTLTFATPLAVTANTTYVASYTAPNGHYSVNHGYFANNTVTSPPLTSPAAVEGAGNGLYSVGPGYPTNSYQGNHYWVDVVFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6X6</accession>
    <name>A0A7W7T6X6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001807</name>
        <name evidence="4" type="ORF">F4559_003273</name>
        <name evidence="5" type="ORF">F4559_004526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="37945" checksum="C60AE78A0EE90A38" modified="2021-06-02" version="1">MTHANAPLTELGRLRLARCVVDEGWPLRRAAERFQVSPTTAARWASRYRELGEAGLVDRSSRPHRSPRRLPTRRERRIVKVRLARRWGPARIAHLLGLNPSTVHRVLRRFGLARLAHLDRATATPVRRYEHAAPGDLVHVDIKKLGNIPDGGGHKVHGRRAGGRNSSAHRDPTRPRKVHGRPNLGYAYLHNAVDDHSRLAYTEILPDETKDTAAAFWTRAQAFFREAGVTVRRVLTDNGSCYRSRLWRDTLANAGITHKRTRAYRPQTNGKVERFNRTLLDEWAYAQAYRSETERRETLPRWLHTYNHHRGHTALKGQPPASRVPNLTGQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T750</accession>
    <name>A0A7W7T750_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase (GGDEF)-like protein/PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="280"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="419"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="655" mass="71071" checksum="E2AEF54E9A283B65" modified="2021-06-02" version="1">MRAVHPTAYVPLSPAEIEEFLLDQVDELLAICTDEPFRADDADEVGKRLVRTDFTDSEAIRVTVELLAKALADAGVPADRLVSVLAAVGAGYAAGLRQHVFDQQEAVKNSLWTAKRRVERVLAASEARFREVFESSAIGIAITDLHGECVEANEALAGMVDRTLAELTGLRLTKLFHADDADPLTDAYRAARSGRVDRFREQRRLVRGDGEPLWVHLAVSLLRDGDGTPAYFVTMVEDVSELHLLQKNLDHQLLHDSLTGLSNRQHFVSRLESMHGARRGAITLYQLDLDSFAVVNNGLGHAVGDELLKEVGRRLEHVVAPDRAFVARIGADEFAIVAPSADTARVPAMIERINEALDRPLPSGAALSATVGVLHRPDARWDVAEVLRAANSTLRRAKAKGKRQWLTYDRHHDAVARPSLEAAARMPGALRDGAIDVEYQPVVAPGSDVVGYVARLRWDGFGHDRCVEMADANGLALTLGQWALHEATGTAAGWAHGVLHVELSAMQSRDADLVATVQRTLADTGLAASSLKLWLDTRAMLDGAGEDNAQVLRDNGIAVGLTRYNGGQAELALARELGVDSLLVAPTVVRRLAREDESVLHTAMSVMTGVVRRTGLAVAVPEVDTPTQARWWTGIGVDLVFGSYYGDPVPSWELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K9</accession>
    <name>A0A7W7T7K9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="368"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="48956" checksum="A76C44580FDF1845" modified="2021-06-02" version="1">MTVQRTAEPRVAAVSNLRDARLALDEGRLGDALEYAEKAVSAFSWLDDAEGVAHGLLVQSVALGKRGLLPGALDTIDRIQVIAAANRHLGLEAWCTYSRAVVELRLDSRERSMHSLARALGLAELTGDPELLGAILYEQARVMRDQYHEHCMIRGETGRCSPDGEPCQRKLRRAEALCAQVRDKWKQLDEPVRLARLNLLLAHVRLDLGEIDRAQRSCQRVDRLLAGVHRPVLHAELLIARARISGARDRVAEQIGQLTRAAELAMTYLAREVAVRAHGDLSLAHERAGNLEPALRHARAQLDQYRIWELQQGRDLLRMREHDLSARLVEQLADRRFEPRREDSVARPLRTHQLRSSTTAEEINRRIARAVQAGLTRRGIEVLRRVANGMTTGAVAEELGLSPKTVQNHLQRVYATIGVRDRAGAAVWWVDLDSPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Q0</accession>
    <name>A0A7W7T7Q0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="81" mass="8585" checksum="F413AD83A8C500AA" modified="2021-06-02" version="1">MAITANYHRSGDDWAVSVNHGTTTLEAVAPGLIAARVQADQLVDEIANGRKDRAVVHLLDGDALAFSVAYLHLRHGLALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7R2</accession>
    <name>A0A7W7T7R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-xylose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030970896" evidence="1">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="32"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="38176" checksum="5D30D48ABB6B8047" modified="2021-06-02" version="1">MRTAVVGCLLVLLATACGSGAEQSAPATPLVGVILPDNSPTARWESQDRPMLEQAFEFAGIEPVIENAEGDEAKFSAIADRMIEKKVKVLMITPLTTEGGANIERKAKSAGITVINYDRISLGGQADYYVSFDNLNIGELQAEGLLGCLGTKRNAQIIEIQGSPTDNSATLIADGQRRRLGPLYDDGTLKLVRSQAIEKWDAGLGSTSFEQILDANNGKVDGVVAANDDLAGGVIDVLRERGLAKKVAVTGQDATLPGLRALLLGEQCVTIYKPIRDEANAAARLAITLAKGDVTGADDLATGNTRDLVARRDVKSVLLGADLITRDNVRQLVVTENVVKPAELCAGEVAPICEQMGILVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U1</accession>
    <name>A0A7W7T7U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="164" mass="17735" checksum="DA3595AF174F41A3" modified="2021-06-02" version="1">MTALTADVVLFTRRRGVLSVLTITRGKPPYEGALALPGGFVEQDERPLEAAVRELAEETGLHLPKSRLRRVGSYDTPGRDPRGAVASTAFHAYVIGAPDVRGGSDAATATWTPLATLLSPTTPTAFDHRRIVRDAVHRRFGRAKALPCRAIRGHRPAQGGLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y3</accession>
    <name>A0A7W7T7Y3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041413">
        <property type="entry name" value="MLTR_LBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17765">
        <property type="entry name" value="MLTR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="30600" checksum="4D0E8F4B113512B1" modified="2021-06-02" version="1">MNHDLGEFLRSRRARVRPDDVGLPGGGRRRVPGLRREELALLAGVSVDYYMRLEQGRTPAVSDAVLDAVSRVLRLDETERAHLRNLVRPARSRRSAPRRVRTGVLRLLESMADVPAFVLGRRTEVLAWNSLAGALYGFDDAAPEMRDSARHTFLDPDARSFYREWDTVAADQVAFLRLDAGRHPDDPLLAALVGELSVKDATFRELWARHAVLEKTHGTKLLRHPVVGDLDLDYETFRLPGEPDLALCVYTAPVGSPTQERLRLLASWSAPIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T834</accession>
    <name>A0A7W7T834_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="953" mass="106068" checksum="4766A1A4EABA154D" modified="2021-06-02" version="1">MFGRRRDRDRRSAAHVAQHAAAASNDRSAYSKRGRRLPGEQSVPSYTPSIAARSIDGHLLRTGQEVYAWYRLAPQRWSFRSDSQRQDLIAAIAGQYAELQGRWMHLRVTTRPYPIRMWAEAHVHNAVRRLPDTHGTLSFDDYMVGEQQQLMGRSMAEKEVYLGVQVQTRNMMDRAVERAAPVLRKVFPDAVDAELVAIESEVDHLDQVIGSAGLEGRPATAEEMSWLMHRSCSLGLPAPRNLPAVPGAPWEPEDLASFTDAADFHQEPYSPTVTVRGRTGSNAGVRRHVAVLTVGLMHGLQIPEVDDPWVQRADRLPAAVEWSARIYVRRPEEVSGELQRQMNKVRSQVRHYTDEHELEPPQSLARQAGRVLEIDDEMTSGFTALGTRVRSWWRLAVSGPTEREALRLAQALLDLYKPKVAIEHPEAQYAIAREFIPGEALSSSAYLRRGSVLWAASAVPTATAEVGDRRGILLGETVTATRRPVAWDPWMAQELRDASGLTAMVAGLGAGKSFLGGGIVYKTLRAGAHWTLLDPSGPLAALCELPELKPYARPINLLNAQPGILNPYRVVAEPQLEHFVDEEDAERAWRRERALAAATRRRLVLDVLTGLLPYEVARLPQTRIVLLRAVRTVGGRPDAHPGQVFEALRRDASEHHEHAVVVADFLDEMRERMSLLIPEEDADPYNEQRDDRLTVLTMAGLNLPKDGVGREHWTDAEALGVEMLNLAAWLTQRSIYERPKDLRKGVWIDEAFFLSEVPTGRVLMNRFARDSRKWNVRVLLSSQIPADFLKIQGFVALLDSVFVGRLDDDQAQADALRLLKVPVGAGYEQVVASLGRRPGGVRTNVERDRAPRQFIFGDGAGGVERIRIDFSGPHLEHLRNALDTTPDALRESGAQTEVEVSSPPQDPFAYAEDYADDIDDELAADLEVGLTDELVDSAHGEGGNRRNGREGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T868</accession>
    <name>A0A7W7T868_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="32825" checksum="CF1A1E7FC1067914" modified="2021-06-02" version="1">MAKVPNRVGVADIEHLERSTAFLRELDYREGGESCRDRASAVLAWSEQLSRARCTTTIRTRLSVALGDLANLVAWTCFDTGLTVAAQRYWDLALEYGADSPDLVANVHYRVGRMRLHAGERHSALRAFDAGLASALSSHTAAILQANCAWVHAGLGDHASAMTCLGAAMSEFSKTRGPVPGWARFFDETDLSAMTGMVHSELARTVSPSSTGRAIQALSIAVRGYGPGATRSRVFSLIALAGNHLREGDADEALRCGTAAMASRVGSGRVLDRLIPLRLLAERNRGDADARELATRLREFTTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T874</accession>
    <name>A0A7W7T874_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] synthase II</fullName>
            <ecNumber evidence="6">2.3.1.179</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="7"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="42619" checksum="A086142D8CF7D57E" modified="2021-06-02" version="1">MTTAGDVVVTGLGATTPLGGDVASTWEALLAGRSGVRPLTDDFVTRFELPVRIGARLAVEPTEILPRVEARRLDRCEQVAVVAARQAWEDAGIAEGDVDLERLGVVVGTGIGGAMTLLDQDDLIEASGLRKVSPLTVPMLMPNGPAAHVGLALKARAGVSAPVSACASGSEALAWAWRMLRSGEADVVVAGGAEACITTITMAGFIQARTMSTRNDDPARASRPFDVDRDGFVLGEGAAIMVLEREEFARARGARIYGRLAGIGISSDGHHITAADPEGLGQSRAIATAIRTSGFATSDIGMVNCHATSTPVGDVIEPQAVRRAIGDHPLLTAPKGHHGHLLGASGALEAIQTLLSVRDGIVPPTLNLENQDPKVPLEVVTGEPRKVELTAAVNNSFGFGGHNVSLVFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E2</accession>
    <name>A0A7W7T8E2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA recombination protein RmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="33874" checksum="C82AB570C55AE04A" modified="2021-06-02" version="1">MIGGVAAVLSTAAVVVALLLAGALVFLWRLYQDGVRRADAALAAIQVERQRADAHREALQRYEVAFSSVSGRGELGEQVLVQTARLLGLREGVHFEVQVDVAGGGSVRPDLVLNVGGGRQVPVDAKMSMATWAEAVETDDPGERADALRVHVRNIRARAGELAGKGYQRFADAIYGTIMFVPNDGAVVAALDTDPELLRWLLDRRIFLCGPTGFAVIASAAMFAVTDRALADDVERVRTQATGAHRAADAAIDAVNLTSTHLQRFLSARRRELDALEGFRAAVEPLSDASASPTPLPVVRRADERNGHGSPLDAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N8</accession>
    <name>A0A7W7T8N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1236" mass="123383" checksum="27815F27A244910B" modified="2021-06-02" version="1">MSADRLRRGGIGGFFSKQWFEIGIEVPDEEQATAEAKPPRPRREADSVDALIDLADNADRARMRGGTRPDPFTTPRHARRDPSTATWREPESTPTLPRTRRESPVEPRTLREPPVEPRTLREPSPVDELVDAVVDEPEERPRASVIRSGEAEVRPAFQDLLAAHGVPAQEDTEDDETVLATRRETPKTSDQATLEGVIPEPDTPVRADPSANGASRTVPTPDPVATSPQEPVVETVRAESPVYEVYDFTSTSDVQAPVDEDSPVEAGSEPMSAGGPESPVGTTSEPDSMPEAPSAVGPVAAESGLSGGVAEPGATGLVAEVDAVEPAAGWSAAVGPTAVEPTAIEPTAVEPTAVEPAVSESTASEPVAAVSVDTEAATGALSAPGPGAPESMAAEPVAEFTVDDSATSGSSPTRPGAGEPAAGPTAAVEPAATAYSPPESITAGQTGVGPAAVGSTAADPIAAGQITADPAAAGSIAAGSVEAVGSGAMGRIDVETSAIGAAEPVADGPAAGPVVIRPVAAESGAVGITGVGPTGVESVGTESIATGVAGGGPEAVGSAATGVVGSAVVDTAAESGPVVPAATGHTAVPPAAESGAVESGAAGPVGADPGAASVVGGEFSESYESAGWPGTSSASDPRPAVGGQGAEPAAASVGEPIFQGYEWEPGSASAAGPIVGEPAPETVAASWLAEVEAGIAGGAMWSESTPVEPAAWGVTESGVFEPAAGGPGQWEPAGGPSVPRPWSGLAAGVPDPIVTEREFGVPSGTRAASGQEFAGQEFVEREPVAGPWSDVESTALSVGYPAGEPEVSDVGESVVRQQFYGAPAPRSAEATGGVPPVVRQPADVSRYADARYADAQYAEAQYAEPQYVGALGDRAGFVPSSGMTASSQHGGPQMAVPSPYIGERTYSPEHGGEPYDPAAAYRLAGEAMAASAGIGGPGTAQAGAGAVGSVARPAPEAASYVAAGPAPQWAAGSQTGAASAPEQMSSGGSGMGFAGMPGLRPSAPGAQEYAAGMPYGGEPQQAEPAVGLGMTAGAMGGAATAPGGESYIPEARVREPLVADIPQDAGGRLRRAPRVALGQLVRAMPGQVVVIIGTSGHTVDVAHWAARKLRVGTDRVFVAGPVALTAGQSRICGPEHAAMLATELHRSPLPAVVAIEIAGSEPDDAEWARDITQALRVDASIAVVDPTRSLVALRRHIAELGKVDAVAVRGPHVDDETIDELALPVLLVEGKPAENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y1</accession>
    <name>A0A7W7T8Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="18536" checksum="2091E8090227E342" modified="2021-06-02" version="1">MDVQVEFLEHIAGRYYGLGEWVASTPEEVRTAVEAMFARQGDRVRTKAAIGRVGESTGLGVLVDPATGYVALHWCLEEHSLNPEPFPDAPLIPDDGDDDPLHFWMRDAYVSEVVARRAIGEYLATGGRPTSVGWQPWGWEVHELPEWLDDEEREKSVGRYRIIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T903</accession>
    <name>A0A7W7T903_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="30150" checksum="752EFFE1F73F1A39" modified="2021-06-02" version="1">MADHRPSPPAARRTARPGAVPACPSCGDLAGRGYPACRFCAELVDQHRLVDWQELLAAEQLTEGGAGERELAELVLADDTGAHPWTCIDWAMTLTLCSHCGEELGTGPVDCVRCAVADERRRHWDHTGFPKEMSALDHRLRVARVVLRAPHRHRTAIVDTWRLLLPFLLDGRLPATGDVRRLRAQVLAGGYADLAAVTSYDDLVAFPELPWRRSAPVEHQADTQRDQHATRKPFERPADTLPRQQAPQAVEHRDDDQVPAGVDGHPHQGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T941</accession>
    <name>A0A7W7T941_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilisin family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030969849" evidence="6">
        <location>
            <begin position="33"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="210"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1072" mass="111063" checksum="CF297FB5CA79BEA2" modified="2021-06-02" version="1">MLGSRSTGRGVAWGATTLAIGLVVGVTTPATAAPPEVPATGIPLAGKRIATPDATVTLLTGDRVSLVGGAVSVRPAAGREKAEFHRFERDGHLHVVPRDAYGALARGKLDPRLFDVTGLIDARYDDAHRDSVPLILQAASTGAAGVSVTHALPGALAAKASKSAAATAYAALVADPGVEKVWLDGLRQPTLDQSTRQIGAPAAWERGLTGKGVKVGVVDTGVDGAHPDLSGRELAQADFTEDNDNVDRVGHGTHVAATIASHDPKYRGVAPDAQILDAKVCVLSGCAESWIISGLTWVVEQGADVVNVSLGGPDGPETDPIEALVDSLSARTGTLFVVAAGNSGRPGTIGSPGSADSALTVGAVERDDDIAVFSSRGPRSDGGVKPDVTAPGVGIVAAKSAEGQIGDPVDATHVALSGTSMATPHVAGAAALLAQQHPDWTGSRIKAALTATAAYNPKLGAYDQGSGRIDLTKAVDSTLTSEPTGLAFGVQAWPHQDDKPVTKEVEYRNTGTTPISLRLTIDAAGPADLFSVSPKELTVPAGGTATATVTADTRGTADGGAFGGAVVATGGPTPVRTPVGVDSEVESYDVTFEVVDQDGSPATGHATDVFGLTNQTVKFLPGDKGTFTTRVPKGDYLVNSSVTDQGRTKGAFLVAPKVQVSGPTTVRIDARKAKPVRITPPDPAAKQGPGELTYRRTHGQYGLLMGVLFIGGYDGTIAIGHLGEAVPAAEFETVIGTTATSDRATYRLSYSDVGRLPDGFVRTPSIRDLAEVRTSLDAAPAGRTFLLGANPTTKNGTGGWGSLDPVPASGKPLDYVTPELRWGWRLEQNSAPDRSDASWSSPDRDYRKGRVYQQRFLRPPFGPAVPANRYLPSIARYQDLLLVSPSLLVDGEGNQGRTAGKGTVALYRDGKLLSKVEAPGVGQFPVPAGPAEYRVDIDLTTAADVLAYASRVTASWTFRSDTATGTTPVALPAGFVRFTPKLDDSGTLRGRSARVPFVVEFDKDSGAGKVRKVGVDVSYDDGKTWSPAPVTGDSVLLKPPAGSGYVSLRAKGSDSKGNRFEHAVVRTFKFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C6</accession>
    <name>A0A7W7T9C6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flhA</name>
        <name evidence="8" type="ORF">F4559_005741</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="679" mass="71394" checksum="0350B212F16C779F" modified="2021-06-02" version="1">MSGKRLSQFAVPGGVLMIIVVMILPMPTFLLDVLIVFDIAIALLIVMISMFVRKPLEFSVFPSVLLLATLFRLALNISATRLVLLDGDAGAVIGAFGHFVVGGSLVVGLVVFLILIVIQFVVITNGAGRVAEVGARFTLDAMPGKQMAIDADLNAGLIDEPEARKRRAEVTAEADFYGAMDGASKFVKGDAIAAVVITLINLIGGFTVGVVQQGMDPLDAVNTYSLLTVGDGLVSQIPALLLSVSTGLIVTRSATDEDMGTQVAGQFSNNRQVLRIGGGALVLLSLLPGLPMLPFLLVGVPLLMLAQRVGGPKTEVEQVDETAAEPARDATETLLAEMAVDPLELALAPDLVDLVDSAGGDLLDRVRALRRKIALELGIVLPPVRTHDDLELPPGSYAIRISGSTVATGTALPGTVLAIGDGLDALPGTPGVEPVFGLSGKWVPAELRHQAELAGATVVDRASVVVTHLAEVTRQNASRLLGREDVRALTDLVRRSHPVVVEELTPGLLSLGEIQRVLHRLLDEGVPVRDLVRIYESLSLTAKSGTDIERLVEASRLALGPAVADPHVQDGTLAVLTLDPRLEQALLTSVHNTDSGTRLALEPQHLETIIGDVTRLVGQAEDRGVSPVLVCAPALRSALRRVVGTAVPRLAVLSYSELSGGSHRIETVGVVNSGYAIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H0</accession>
    <name>A0A7W7T9H0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="224" mass="24727" checksum="190AF11DA5F1EF34" modified="2021-06-02" version="1">MDETLARAGIFQGVEAGAAEALAQTLESVEFPRGHVIFAEGEPGDRLYIIQSGKVKIGRKSPDGRENLLGIFGPSDMFGELSIFDPGPRTSTATTVTEVRAVSMDRPALRQWITNRPEIAEQLLRALARRLRRTNSMLADLIFTDVPGRVAKALLQLAQRFGSQEAGLLRVTHDLTQEEIAQFVGASRETVNKALADFAHRGWLRLEGKSVLILDPERLARRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9P1</accession>
    <name>A0A7W7T9P1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009319">
        <property type="entry name" value="Phage_A118_VSP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06152">
        <property type="entry name" value="Phage_min_cap2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="634" mass="69786" checksum="E3F73D13286A8077" modified="2021-06-02" version="1">MAWEPPPDSDPAEVVEQLARDLLAVFTEAEARLLADIARRARAGVEIPEWAAQKAAAAREVRLAVERMLTQLRTEVGTGAAEAVLAAWQAGSAAALAQLADLGALDESQLGALREVIPGMDAAALLAADLTSRLDALYLRVLRWGQDAYQVAVAAAAPAQLLGTGTTRSAQRAAWDRLVADGVTGFVDRAGRGWNLASYVEMATRTATARAWNEGHLARLDSLGVDLVTVSNTTDGCALCSVWQGRILARTGAAGERTVENELTGDPMRVDVAATVDEARAAGLMHPNCRHTFLPFIPGVTRLDEPVEHDQAAENEREDLRELERKVRREKRKEAGALDVTARRAAQQRIRALQAEIREHVDATGLNRKRHREQLNLGHGTATAARARRAAVADQVAEGTAEQARLDAVAAEQAARRERERLAAEQAERQRLAVMTDDELAAHLAEVADDDAAVEAVLAEMDRRDAEAEQDQGEQLDEHQDAEDDDPHAEQWAQVDRLVAEGYDYQQAYAEAFEVDLERLRRDDAIARLRADGFTGRGFDELARAAYAKALDEQYLAAEAATNGYMVTNEGRRAQIDPRNLWRQNETYARKWASDELKEWWDANGRLTFDQFREELLNGGNGERHRTGGETWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q6</accession>
    <name>A0A7W7T9Q6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone reductase-like Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="33841" checksum="24F42965858DE957" modified="2021-06-02" version="1">MRAIVHERYGDPVEVFRYLEVDKPAAGPGEVLVRVHAVPITGTDWHLARGLPYAARPGIGLRRPRNRVFGLELSGTVEGIGHGVRTLAVGDQVFGWAAGTFAEYVAVPETQLVTKPVNLSLDDAAGGPIAAFTAFQAVKVGNVDGKHVLVSGASGGVGTYAVQFAKAAGAEVTALCSPRKADLVRGLGADHVLDYREFAYAGRGFDVLLDVFGVPSVRQCRDVLKPRGTAVLVGGVGGRWFMGTDRWLRAAIAAPFLGVTMKPLVHKDSLDDLGAIKALIESGAVRPVVGEVMSFDLVPEAIESVRLGLPHGQIVVRIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U1</accession>
    <name>A0A7W7T9U1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15981" checksum="0AEA244AD4C23907" modified="2021-06-02" version="1">MTTPPGRPDQPLPGEREAHLSVSAPKSRRRRVVLADPKGRGRVLRTIGELEEQTSVGEKLIRDLIRTQLRSAFSLGLGLLGFFALLPVVFYALPQLAEVELVGVRLPWLVLGLLPFPLCYTVGYAYRRLAETNEQDFVNSVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA18</accession>
    <name>A0A7W7TA18_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="506" mass="52608" checksum="D0BECB422C0EE409" modified="2021-06-02" version="1">MSGGPIQNTSLTPGGVIGDGRYRLLARSGVDHRCAAELWRGRDGQLNRDVALTVMVGHPGEQQQLARAKRVAERAMHSSSFTHPGVARVIDVLTPGSGIRWDEGILAMVVAEWTQGTDLADLLTDGPLPAGAASRLLEPLGAAIEGAHHAGLVLGADHPHRIRVASDGRLRLAFPGPRPDAIARDDVKGLGAVLYLLLTGKWALPGGPPEVPVAPTAPDGKVVAPSALQPYVPHELSSVAVRSLEDTSVGGIRTSAAILQVLDRMSASEAQTALLSPVPGESDDGAVWTTERPKAGREHRRKLLISVAVLAIATLAVVVWLGIQIVGFFSDDGGPGGGPTVVVGQSNAPGDSAAPAPPAPAGPVQAASVGVYDVTNQPDNANRANRAVDNNPTTVWQTDNYYQPFPALKPGIGLMAGFAEPVKLASITITSPSAGTVVEIRTASADGVPLQETKVIATATLSAGPTQIQLNAHEPTQHVLIWITKLAGSGRDNKTEIAELVYTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT20</accession>
    <name>A0A7W7WT20_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage shock protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14705" checksum="6A3FC595552956E8" modified="2021-06-02" version="1">MGHAWRTPEVRTAEEVLGRTIAEADRSMREAAKVRPGREPSAEDVRRVMAYAKSPDASPELQAVQRRVARGDLSWRQILLGEASGDRGVRAALEAERTTLAALCRGEDPRPAPRRPVRTEDDEPTSFTEDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI6</accession>
    <name>A0A7W7WTI6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030542818" evidence="1">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="6456" checksum="C9E7314B72CF0C68" modified="2021-06-02" version="1">MRILGKVALALGMPAVALLAASPAASAADESAHGGAGLLFRDVVEVHDSLIKAEVLPIHTGGALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTQ9</accession>
    <name>A0A7W7WTQ9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">F4559_000107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="27321" checksum="E2311FA732D0CC2E" modified="2021-06-02" version="1">MAVGTLVLLRHGESVWNAENLFTGWVDVALSEKGVGEAKRGGVLLRDAGLLPDVLHTSLLRRAIHTANLALDAADRHWIPVKRDWRLNERHYGALQGKNKKQTLAEFGEEQFQLWRRSYDTPPPVIERGSEFSQDADPRYAGLGDDLPLTECLLDVVKRILPYWDEEIVPDLRAGKTVLVAAHGNSLRALVKHLDGISDTDIAGLNIPTGIPLRYDLDDDLKPTNPGGTYLDPDAAADAIKAVANQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU1</accession>
    <name>A0A7W7WTU1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2154 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024425">
        <property type="entry name" value="DUF2154"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09922">
        <property type="entry name" value="DUF2154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2154" evidence="1">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="213" mass="22408" checksum="30CB2FEC8B7C2510" modified="2021-06-02" version="1">MSDELVPEPSQMRASDADRQKVAELLQRAHGDGRLDLVELDERLAAAYAAKTYGELVPLTADLGGPGLPVPAPIGGNHPSQRVGGTPGSASSVAIFSGVERKGEWVVPATHTAVAIMGGVVLDLSKARFAQQETVINILAFWGGVEIYVPEDVTVRVDGSGIMGAFDDSTYKTPTVPGGPSVRITGLAVMAGVEVKRPKKKKLKGRKNPELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU31</accession>
    <name>A0A7W7WU31_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031004035" description="P/Homo B domain-containing protein" evidence="4">
        <location>
            <begin position="39"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="5">
        <location>
            <begin position="466"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="584" mass="61849" checksum="000C43A71CCC7945" modified="2021-06-02" version="1">MKSRRTLVTLAVTALAAAAVAVGGVPGNAGPTPDTAVAQPGPTYVYKVHAPLGTSTKALFAKGFDVLEDRDGDYLFVLGGANTGQDLKQAGYTAVVDEVLPAPTWEPPSAKAQARTSAEETYYGGYRTINAQWAHLDQVASQYPNLTSLVDYGDSWKKTQGSGGYDLRAICITKKNAGDCALNTNAPKPRFFVMGQLHAREITTGDVAYRWIDHLTQGYGTDPEVTALLDTTEFWVVPIANPDGVNIVQQGGNSPRYQRKNANTTNGASCSGTSGSHVGIDLNRNTDSHWGGEGTSSSPCAETYKGPSANSEVETRALQALWKNLYKDRRGTGPTDAAPADTTGIVLSMHSYSNLVLFPWGWTTQYKSGNDAPLRSMAKDLATMAGGWRYGQPGEVLYNAAGATDDWVYDALGVASFVWEIGPSSGTCSGFLPAYSCQAGTFWPKVKPMLLYSAKKAASPYGGGTPNPGTCAKQTNDADVQIPDGGASVTSTITVAGCTGTASASSQVEVHIKHTYRGDLVLDLVAPDGTAHRLKSQGNDSADDIDTTYTVDLGGKARNGAWQLRVQDVYVTDSGFLDSWSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU48</accession>
    <name>A0A7W7WU48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19616" checksum="D7F0DFE749BBB1DE" modified="2021-06-02" version="1">MSTYADPSKAVVWLDGDAFRAPAGTALPADIFAASLSGWEAFGGIKAGFTVQRTQEITKFTIFNANGTYLSVKGDEDGTIKMRPVDMSKATALTLLTGGSIVAAAGGYEWVKGDDEKFAYICRVSAGTRRKAYFLKKSELANIPDDVLNDEDLAGWDMEISPLIPDDGSRFIRVFTESNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF8</accession>
    <name>A0A7W7WVF8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1012" mass="107084" checksum="82EB2B7420123641" modified="2021-06-02" version="1">MDLGAPHGIRFRFESGLLRAVLLDVHGKPPLALGEHLSASGGARDLVVSPGEPVPGDGGVHAVLTLRFDLPEPARWLLTADAPAERAGDGVAFTAPDAVRLSVSATRPCEVVENGVAVELPAGVSEVDITVASAPVYPIADTAVVCRPDQVLEAAVVLSCLPGDRFTPLLTTDDREAGDLAVAMGVRRVVHLTGGPDLVGTERLDLRCDDLSVLTKAARDLLDVDGPTLDVAPDADPATALLLARRTGAVLRVVEGAAPVPAVPDAGTDEAVLVEDTGTTDVLVAALYAHHRGARLVVTPVPDLTVLHDLLAHDHAAYDDAYQRHLVDAVADAVTAQVPAHVVDAVGDRALTAFTTGLPYPFVRTWDSDWARKPVGHVLDRAALVVLTEFHAAAGPRPAATFAVVVDADCEPAADPGTAHHFTHPLVLTPDEATPEALRWLTTALPVELVHLGPDADEPGPLGHRPLVITRAARPWAGTGRRRLRAGARGAVVALWPVSDDLADAFARVVVDRLTAGEQPAARAVVGTGTPGDVERAHVCVGTVDTRLDPWRDRSTTADEAAAAHGGLLAAALPDCPDGLVPVLRRELTVVRVAAEAGDVTGSVAYVDLLLAESAHSDDVPALIARLDAVLPDLDLPDDALDRRLARRHELLGAYYESRGDDVAAADEYERCTARGGGPHVLVRAARTLARSGESDRARHAAARARAEGDRATVLEATEVLGGLSERADDHDEWLRYTSEGRELAAEDGDRAALARFTFDRCRALHRGGDLDAAIATGVEAAELFRELRDEHAELGVLRVLGLCHQDRGDLDTAGYYASAALAQAERLGAHVDVAELHGDLGRLSTARGEHPQALEHYRHAVEKTVAHGAWEPAARLLPDLAVGAVRAADTHALWTTALCGGLICETAERDVWQSLVPLVVDSLKRAIETGPVELTQRGMTDFAGAVTTGERADMPVQVGMLADVVVVLLAWLMDRVDDHILGFAHELDRDTGGVLDLVGYVSVPYRQRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVI6</accession>
    <name>A0A7W7WVI6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="47" mass="5172" checksum="5B8A6163F2187432" modified="2021-06-02" version="1">MSGDPPEPVVPPPPRCGRRTFPDRDRLDALEARMAELLDDEPEGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVL8</accession>
    <name>A0A7W7WVL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="18996" checksum="43A26371336E3F5A" modified="2021-06-02" version="1">MPPTGRADARRNRELLLEAAHSLFTEVGVTDAAMNDVARRAGVGPGTLWRHFPNKDALLAEVIGADLDRLADLADATSGDRLRDWVGALVAHIARYRGVAEALARAVVDGPLAGRCHGLERAAAGLVDRARSAGVVRDDLTWVEVVDLAKAVAWVGESTPAAARYVDLVFEGLVTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV4</accession>
    <name>A0A7W7WVV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRP-like cAMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23461" checksum="78FE6FD548CE367F" modified="2021-06-02" version="1">MRIRGFRGLLGEDGWRLLLRQGVERRYPARTVLMRQGDRGTDVVVLVTGRVKVLGVERDGGQALITLRGAGDLVGEVAARSAGGRTATVETLDRCTTRVIPAAAFGAFLDEHGGTSALLDYMAAKLSQTVRHQLDTVHHGPERRIARLLLEVVALADEAADPPTRVPFSQRDLALSLGLARSTVADHLRRLKEVGALRPGPRLDVVDMAALRHVAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW26</accession>
    <name>A0A7W7WW26_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SSI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_002477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the protease inhibitor I16 (SSI) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000691">
        <property type="entry name" value="Prot_inh_I16_SSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023549">
        <property type="entry name" value="Subtilisin_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036819">
        <property type="entry name" value="Subtilisin_inhibitor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00720">
        <property type="entry name" value="SSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00294">
        <property type="entry name" value="SSBTLNINHBTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55399">
        <property type="entry name" value="SSF55399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031539803" description="SSI domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SSI" evidence="10">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4965118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13015" checksum="2C9868D67F8D0CED" modified="2021-06-02" version="1">MRIIGTALSAAALVVATAAPAGATEQTGLYLVISDPDGTWGRGVSLDCPPNRALHPHAESACADLDMAGGDFDNLPGDQHPCTLEYDPVEATAEGTYQGNSVRWTAEFSNACTLDADTGWVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR1</accession>
    <name>A0A7W7WWR1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20472" checksum="C2286AAE6B53A7B8" modified="2021-06-02" version="1">MSISPGDDGAVTAWALAAGAGDRRALERFVRATQRDVWRLVAHLTDPGRADDLAQEVYLRALRSLPAFEGRSSARTWLLSIARRTVVDHLRAAGARPAIAWSADYHQAADAASAAGRDRAGFEDVVEVTVLLADLSPERREALLLTQVLGLSYAEVAEICGCPVGTIRSRVARAREDLLRDKGNRDAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU0</accession>
    <name>A0A7W7WWU0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOSC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="117"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="28764" checksum="41E98304BCE141DC" modified="2021-06-02" version="1">MPRITRLTTYPVKGCAGVDLTTTTLTTAGLRHDRDYMVTSPDGTFRTQRTDPTLALITPTADDTGLTLTAPDAGETRIPHDPTAPRRTVTLFGVHYEALDQGDEAADWLTHVLRTPSRLVRVPPDHHRITAGLTPGTCGFADSGAVHILSTATLDHLNSRLDTPLGMDRFRPNIVIDWTEPHTEDTTRRLVIADTELAYAKPAVRCAVTLVDQHTGTRAGPEPLRTLARYRRDPDGGVTFGTKFSVLRTGNLTVGDTVHVPAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB0</accession>
    <name>A0A7W7WXB0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="25270" checksum="E4D1F6670F7138D4" modified="2021-06-02" version="1">MIGPLRVGAATHVGLVRTSNEDCLLVGRRVFAVADGMGGHAAGEVASAMAVDALRGLDEVDEPRPEHIRAVLVAANDAIRDAADADPDRAGMGTTATGLVLTGFNGSPHWAVFNIGDSRVYRHVGGGLVPLTADHTEAAALVASGAMTAEQARTARQRNVITRALGARVAPEPDQWVFPPEPGERFLVCSDGLTNELPDQEIADILDALPDAKEAATTLVRRAVLAGGRDNVTVVVVDHDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN2</accession>
    <name>A0A7W7WXN2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hygromycin-B 7''-O-kinase</fullName>
            <ecNumber evidence="2">2.7.1.119</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.119" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008904">
        <property type="term" value="F:hygromycin-B 7''-O-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016259">
        <property type="entry name" value="Hygromycin-B_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000707">
        <property type="entry name" value="Hygromycin-B_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="53"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="34858" checksum="61BF8433D7A0E990" modified="2021-06-02" version="1">MTFPLADTEERFEAVVDDESALRPGVDRLLGRLDLRGEPVRYPDGSLPVYRVGEHVLKLFPAVHLEELPTERDVLRAVHGRLPVPTPAVREAGEVDGWGYVLMERLRGTGLVEVWPTLDAAGRESVARQVGEALAVLHDLPSPVDHPADWSSFVAARRVAPRRPVDPAWADRVDEFLDRVDLGADEPVLAHTEVMSAHLLVEGTRLTGLIDFEPAMRAAREYEFVATGIFLTRGDQAANRALYTGYGRPVDPLRVMAYTLLHVYSNLAWYLREVPPPADVDTLDALARHWFGSAPVRPSSRTMDADAEAREARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX2</accession>
    <name>A0A7W7WXX2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="37706" checksum="4683DB21A4C404DB" modified="2021-06-02" version="1">MTHANAPLTPVGRLRLARCVVEEGWPLRRAAERFQVSPTTAARWASRYRESGEVGMADRSSRPHHSPGRLPTRRERRIVKVRLARRWGPARIAHLLGLNPSTVHRVLRRFGLARLAHLDRATAAPVRRYEHAAPGDLVHVDIKKLGNIPDGGGHKVHGRQAGGRNSSAHRDPARPRRVHGRPNLGYAYLHNAVDDHSRLAYTEILPDETKHTAVAFWHRAQAFFQAAGVAVKRVLTDNGSCYRSNLWRDTLAQAGITHKRTRAYRPQTNGKVERYNRTLLDEWAYAQAYRSETERRETLPRWLHTYNHHRGHTALKGQPPASRVPNLTGQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXX8</accession>
    <name>A0A7W7WXX8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="156" mass="17622" checksum="F091F0845E7B196C" modified="2021-06-02" version="1">MGTITVRTAEHADLDTVVDIHIRSRRGYYEGHVPESVLRDWEGRVRAAGYRLDPGPTRRWLCAELDGLLVGFALVTATGRLWQLHVDPDRRGNGVGTALHDACVAALVGLGARRGELDVFVDNHRGREFHRSRGWREVGTTQEEYVHVLMERDLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY6</accession>
    <name>A0A7W7WXY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PST family polysaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="49772" checksum="7F17792D33A00CB5" modified="2021-06-02" version="1">MTTLEGKVTSAIRWSAINSLLQRVGQVGVGVLLARLIAPEQFGVFAVALVVLNIVLSVSEMGVSVALVRTERPVAELAPTVTTLSIASGVLLTAVCVIGAPFFADFMDTPQATGVIQLMSTALIIAGVSAVPGALLQREFRQDHKFAADTTAFVLGTATVIVLALLGFGAWSLAWSRIVTNLAAAVVMFAYTKERYRPGFSPRLAREALSFGLPLAGASLLVLGVMNVDYIVVGSILGTVPLAFYAQAFNLANWPVGAFSQPVRSVSLATFSQVRDDQELFQRTFARALGLLALVTVPACVLLAALADPIVRVVYGERWAPAAAALALLVLLGAFRVALELGYDLLASVGRSKAILVIHVIWLVALVPLLALGAHLDGIRGVAAAQSVVVLVFIVPAYLIAFRPYGLRAGALGLAVARPAVGGVVMVAVAVGVQWLVADSLMRLILGGALSLAAYAAVVFPLRHEVLGLLRRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY35</accession>
    <name>A0A7W7WY35_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-oxoacyl-(Acyl-carrier-protein) synthase/NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="7">
        <location>
            <begin position="329"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1005" mass="104733" checksum="B1DF272CD67B5FB1" modified="2021-06-02" version="1">MTGPLGGRVALVTGGAGSVGERIVRGLAEAGATVLINCFHSYDAGRRLADDLVSAGHHAEVMRASVAKPAQVERMVAEVDRTHGSLDILVNNAAAGTFASWDELTEEHLDQAFATNVKGALWCARAARPLLARGTDPCIVNVSSIGASHAPANYLPVGIAKAALESLTRYLAAEFAEDGIRVNTASAALLDNEVGRRFPGADSVRANTVAATPAGRLGDPDDLADVVLLLASPGSRFVTGQTLLADGGLSLMRHAMAPTPSTPSTTASSTLHGDERHPVRHSRPTSTDPATDGESPSRVTTPDPVGSDHTTASVPTTDRPSLPTDPDPVVVVGMGLAVPGASDPDGFWRLLERGGEQFVEVPPDRWPAHAFHDDDPDAPDKTYQSRSGFITDFTPHPRLEPDFAADPTAKWLRHSAIQALEHVTTRPGDRFSVCVGYTPDGSPHLQEALVRGELEALADPEHAAEVAAFADRVLPGSRTGHLPLSHRIGQDALRGLVPDDARLVMVDTACSSSLYAIDLGIRDLVAGRADVAVCGGAFALAPPGSVLFAKVRGLSRTGAVRALDRDADGVLFSDGAGVVVAKRLSRALADGDAILGVLAGSGLSADGRGKAIYAPSSGGQSLAISRALARTGIGPADVDWVIAHATGTPAGDEAEFTALRDAYSSGTVQVTSNKSLIGHTGWAAGVVSVIQALLALRHGRIPAQHRFTAVPERFGIEGTGLTVPTESVPWPARADRPRTVAVSGFGFGGTNAHLLVQEYRPGRANRSGYGTRAARPAVVVGWSTHLADGGTFGDAYPHPPFHLLRMPAAAVRATDRTQLAILECVDRLPAEVRAVCEAHHARVGVVVGHTGPTRSASLYGLRAYLDALDEAADTESVKVLLKRARHHATGLIGAPTEDSFPGGMPNVIAARPCNRFDLRGLNVAVDGGDESLSQAFATARRYLEFGDVDLVLVAGVHGNTLPSWRALTDSATPPTEGAALFAVATGDLAEATGLPVLAELTEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY89</accession>
    <name>A0A7W7WY89_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="154" mass="17215" checksum="B5FDB6B431760272" modified="2021-06-02" version="1">MKRLFRRRSKVLPTIGPYDDVRELCESLGARRGRVIELVAMPLSPLGMSGLWLAAADVDIVCYESGTSRPHQDHIILHELGHILYGHAQATEVADALAPMFTALDPGVLRVMLARRHHTFGENEEREAEDFAYATLALRRDPNDTTPLMRALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY99</accession>
    <name>A0A7W7WY99_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7604" checksum="182E3DACD1FBAF24" modified="2021-06-02" version="1">MSDTTTADRLRIALSDVTYPADRDRLADHASRNNADEDTVHAVRSIPDGEYPSFDAVLEATAVDETREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK0</accession>
    <name>A0A7W7WYK0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="66"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="530" mass="58246" checksum="89B558CF6211D4BB" modified="2021-06-02" version="1">MAALAATACATPAEPEATVDTDAGITIFNTEPENPLVPGNTTEVGGGNVLDPLFTGLIEYDPKDAKPVNAMAESFETKDSKLFTVKLKSGWTFHDGSPVTAKSFVDAWNWTAYGPNAAQGASFFSQIEGYSAVNPKDPDGPDGPQPAPTPTANTLSGLKVVDDTTFTITLSEAFSVFPVTVGYEVFSPLPESFFKDKAAFEQHPIGNGPFRFVSRVVGQEIKLTRWDDYKGGEKPKFKDLTLKAYQSREAAYGDLVTNSLDFMEELPPNALAGQKYEQDLGDRVVQRETLNNQTIAFPFYLKPYDDVNVRKALSLAINREEITQRIFEGSRKPADGWVHPLTEGYKPGQCEFCKFDPTKAKEYWAKANYTGPIILQSNTDGGHQEWAEAVVNSIKNTLGIDIKFVPTTSFGEFRQKVNAHEMTGMYRAGWIADYPSIENWLTPILRTGASSNDGLYSNPAFDAKLAEADKAPSKDEANKLYQDAEKIAAQDMPTIPLWTQNTIGGKSNRLKTATLDPFRSLDLFSVEVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYN0</accession>
    <name>A0A7W7WYN0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="842" mass="91613" checksum="F638E57CBE1F1D61" modified="2021-06-02" version="1">MTGQFDTARFIDEVLKPIQDGWRPDEDLFRVYLLRTDVTDDRTISAALEEVARQLTKQQYRMFRRATEILRGLQKTGGEVLLDPARREKHRKQVEAARGRLASTVKLRLNGAPALPPAEVAAQARTLKVPRSAILAALRDARGDVREPAELPPTAEPRQWAEARGHLTQLRQSSLWDYVTDLGGVDTTVAHLSARREKLRVARNADSAAETTLLQLIRGWIENGGLAPVLRYELLTDLADRSAYGYDEALSAAKAASGRLRKVGVTADPAAIAYAVWCGRAFTAAEPTPSWQEPYQQAIGELRLRAALTVLRQQPNLPETWVAQRTELEGRLAALDAELERCEALERADVEAAVTGYLKVRQELVDDRIDAALERCRPAPPASATATIHNGQITVAWPPSPARAGRITYRVSRAGTVLDEGGGREYTDREPPSGTPLVYAVHALRDGTPSAEPARTAPVVVLGEVLDLDVRGGPDAVTGRWRLPPGAAGAEVTRSGRPVADAHSTTFTDPDLPPGRTEDYLVRVRYRLPDGTIALSTGLHRSASRQETPVAVTDLSARFEDRDLVAEWTPPPRGEVEVLELPDGRTPPEPDVVPVDRARRYGTVIPARGASGRGRLRATLSSVGRRQVLLPITVLGELAAIGTAFTLDARQSPVSGLRADRLGTAVQLTWEWPPGSTSARVVWRPGVKPTGPEDPKASAVDLTRVSYDGRGFSVTVPEGDHWFGVCTSVSTDDVRAFGPLSLTRESTVGTVSYQVVPGPWYARKRRKLIVGGTVPVVLVARSGVRPMNPSDGEVLVRAESGGSTEFEVPAGLRRPVHLRAFSRDDRVVLVPTRPDQLIVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ16</accession>
    <name>A0A7W7WZ16_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Deferrochelatase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peroxidase EfeB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22585"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="6">Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033212">
        <property type="term" value="P:iron import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006313">
        <property type="entry name" value="EfeB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01412">
        <property type="entry name" value="tat_substr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031611599" description="Deferrochelatase" evidence="6">
        <location>
            <begin position="31"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="415" mass="44364" checksum="8B18B642D5058662" modified="2021-06-02" version="1">MSGIPRRRLFGYAGAGVALAGAGAAVGALAAAPPAVRPAASLADAVPFDGEHQAGIVTPAQDRMHFVALDVKTTKRDELVGLLKDWTVAARRMTEGREAAELGAVGGRPEAPPKDTGEALGLAASALTLTIGFGPSLFDDRFGLKDLRPAGLIDLPRFPRDDLDERRSGGDLCVQACANDPQVAVHAIRNLVRIGFGRVAVRWSQLGFGRTSSTTRDQATPRNLFGFKDGTNNIKAEDADALRDHVWVTADDGPRWLVGGTYLVARRIRMHVEIWDRTSLAEQEDLVGRTKGSGAPLGQVDEFDPVDLHVRGAGGAPRIAADAHVRLASAESLGGARILRRGYNFTDGTDGLGHLDAGLFFIAFNRDTARQFVPMQQALSTKDRMMEYLEHTGSGHFAVPPGVREGGYWGDTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ73</accession>
    <name>A0A7W7WZ73_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17706" checksum="AFD5DA110545200F" modified="2021-06-02" version="1">MIGEDWARRCLDRADRRAVGFLLLAVAAVLALWLVSELIGSRWVFVLLPLCVEFAVPGLRHFLCRRAVRRLLEAHDWHPMSVSFVAGRARVGRQAYLETEGSDRTFLRLPEMPERVREYVRRTGQVWLAGPDARGRTVVVTRGTPFLTLGRVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ78</accession>
    <name>A0A7W7WZ78_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="91" mass="10369" checksum="2AF7D7464F78E59F" modified="2021-06-02" version="1">MDASLFSLVSEDAPSLVFAWGMEIIDEDGTKAIIYRPATRTERSLIGKHDSAEAALRRWRRHFPLKLVWDYEDVDLPDEADESEESSETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ90</accession>
    <name>A0A7W7WZ90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N,N'-diacetylchitobiose transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031330015" evidence="1">
        <location>
            <begin position="27"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="44545" checksum="A856662E4639821E" modified="2021-06-02" version="1">MRFVLAAVAVSAAVLAGCAPVQSGPAASSGTDEQTGTLRIWLFDEVNRAPKEAVVKEAVEEFQKANQGVTVDVQYIQTSSRAERFKAAFSDPKSAPDVAEFGNTDLAGYVAGGGFAELDLSSWADSKDLLPAVLDTAKVDGKTYGVPWFVGVRALYYRTDVFTELNLKPPTKLDEIAPLARQIRAAKPDLLGISAGGKYTYAAMPFVWANGGDIATKSGDKYVAKIDSAESKAGLEQYTDLIADDICPAAQCAGNGGDASVEAFRAGKAAMVIGGDFNRKSVDASQAAGKYAVVPLPGKDAGSIAPAFAGGNLLGVLKGSERKTLANKFVQLLAGKQYQRKMFDAMGNMPTFGDVQDEVAKSTPAIGPFVKTLAAGTKFVPVSANWAKIDAQAVLPTLIQEVATKTADLDTASKKAADSMNAAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA6</accession>
    <name>A0A7W7WZA6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaK</name>
        <name evidence="9" type="ORF">F4559_005957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="623" mass="66829" checksum="78432629EF997CC0" modified="2021-06-02" version="1">MAKAVGIDLGTTNSVIAVWEGGEPTVIANSEGARTTPSVVAFTESGERLVGQLARRQAILNPKGTIYSAKRFIGRKYDEVGEEAKAVGFDVVEGPGGVVRFKVRDKLHSPEEISAQVLRKLADDAGKFLGERVTEAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAAIAYGLDSKAHETVLVFDLGGGTFDVSLLDVGDGVVEVRSTAGDTHLGGDDFDRRIVDHLADRFQQENGIDLRSDPQALQRLFEAAEKAKVELSSVSQTSVSLPFITADKDGPKHLTTTLMRSVFEQISADLVERCLGPVKQAMADAKVTANDIDEVILVGGSTRIPAVQSLVRRLTGGKDPNMSVNPDEVVALGAAVQAGVLKGEVKDVLLLDVTPLSLGVETRGGVMTKIIERNTTIPARRTEVFSTAEDNQPAVDVVVLQGERERAADNRVLGRFQLTDIRPAPRGEPQIEVTFDVDANGILDVTAKDKDTGAQQGITISESSNLDQAEVDRMVTEAERNRSEDQRLREEIDARNLLDSAAYQVERTITDTTAPHEKARAEMLIQEAREAVKDAAPLDRVRSLTSELQQMLAGLNAPRASGGGNGSGGGPQQAADEDDVIDADFDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB0</accession>
    <name>A0A7W7WZB0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="19209" checksum="F03E6FC8778FF82B" modified="2021-06-02" version="1">MTSDERDRKTTERARLRAARRSAPAAPMSAEGLAAVEAFGVVPGGTVCAYWAVGSEPGSRAMLDALSAFRVLLPVVAGDGPLDWAVYAPDALRAGPYGLLEPSGPLLGVSAVASAAVVLVPALAVDHAGVRLGKGGGYYDRTLAAATGALVAVVRDEEFVEVLPAEPHDVRMDAVVTPGRGVVRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZL9</accession>
    <name>A0A7W7WZL9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="659" mass="68295" checksum="2148AA176CA38B78" modified="2021-06-02" version="1">MNDPEVLYGQLASGDAGRVAAAADPISGAMSAVSRAETSVSSGGRTATSAWTGESATKFGARAELSSRAAVVAGERLGVGVDVVQAASRAYAQMRGSADSIIAVWRGRPPTLDAAQTMDLAGRVNEALNNVKSGYEGVLRSYASALSSVRPGFEETAGKDAGWATSVQAMRTSTTVPAPGTDPKQVAEWWKSLTQDQRDELLRTKFQELGQLRGLPSDVLDKANRARIDDDLQRFGAQRDLLDAQMADRARELGLDPDTSDGQTKLMNDPQYASLMEQRQEAATKADNAAAVQDSIKKAEDIATERGWFNAEGRADVRVMAWDPYGPRGDGATAIAYGNPDTAKNLAVCVPGTGSTLGDFGVDQAANLRQAMGAEGNATIQWLGYDAPGWALGEVDNPAQAREGGANLVADVAGYRAAGAPGQHLTVIGHSYGSTTVGYAGMNGLAADDIAFVGSPGVGASNVDQLSVGPGHVYVGATEHDPVVQGTSSSWFTEDGSSTGPYDPKFGARTFGTPEDASLLGAHSQYYREGSESVQNLARIATGDGASVTEQKWYDSPLGPSGPFSDVPGVGPVVDVVTGTVAGAADLVGDAATGVYDAGRNAWNGNWSEAGTGLVNTGRELLNDAGDIVVGGVGDVVEFGRDVVEGAGSLWDKTVGSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZW9</accession>
    <name>A0A7W7WZW9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_006647</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4969288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="39023" checksum="706B242A4E2037F6" modified="2021-06-02" version="1">MLNFIYYPVSFILWCWHWVFGHIFGESSGFAWALSVVFLVFTLRALLFKPFVGQVRSMRKMQEFAPELKKIKEKYANDRQRQAQEMQKLQAEHGVSPLGGCLPMLVQIPVFIGLFHVLRSFKPGWGEVYFFDAQGVESFVNAKLFGANLSTFITMPAEELAKYATERPAVLAVSIPLMIVASIATHFTARHSVARQTQAQTDNPQTAIMNKLTLYIFPLGVLVGGLFFPIAILLYWLSNNGWTLMQQRLVYTRIDREEETKKTEALAQRAALAPKPGSKPQPGAKPQPGAKPKPGAKRTTPVRLPPGKKPAAPAAEKAMPAADADDTPSTEIPGLEPGRSASRKQGSKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXE6</accession>
    <name>A0A7W7SXE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4962724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="28869" checksum="6B3AD5227D8598C1" modified="2021-06-02" version="1">MAWSIAQVARMSKVTSRTLRHYDSIGLLTPAWTGDNGYRYYEREQVLRLQQILLLRDLGLALDTVAEVLAGRHRAVDVLRHHERQIRAERERLATLARSVAKTIAELEGGPEVKMEELFEGFDAERQARYEADLVERYGEGVTEHIEDSKARMKGWSKADAADFMAEWEEIGKAFAAAFDAGVAPDDQRVQDVTDRHYRWILRSWTPNRESYTGLGQLYVDAEDFKVQFDAHAEGFAEYVRDAIAVYAQTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXP2</accession>
    <name>A0A7W7SXP2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ring-1,2-phenylacetyl-CoA epoxidase subunit PaaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009359">
        <property type="entry name" value="PaaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038693">
        <property type="entry name" value="PaaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06243">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030200">
        <property type="entry name" value="PaaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02157">
        <property type="entry name" value="PA_CoA_Oxy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="94" mass="10554" checksum="3751BF6BC3BBBB35" modified="2021-06-02" version="1">MSASWPLWEVFVRGKRGLNHVHVGSLHAPDAEMAVRNARDVYTRRNEGVSIWVVPAAAITASSPDEKDPFFAPSGDKVYRHPTFYEIPEDVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY24</accession>
    <name>A0A7W7SY24_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005274">
        <property type="entry name" value="IM_pro_YhjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00766">
        <property type="entry name" value="TIGR00766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="35814" checksum="3D3C4467B0E626E8" modified="2021-06-02" version="1">MAESKPESKIDRLRRERPWLDHLVRAAQRFSERYGTHYAAAVTYFSVLSLVPMLMIAFAVAGIVLSNQPGLLRELQSSITEAVPGALGDTINDIVGEAIESKGTVGVFGLLGAAYSGLGWMSNLRDALTAQWGHAKEDLPLLKTALKDFVALLSLALALVVSFGLTAAGTGFAELVLEKVGLTGVGWAEAGLKAGSIVLSLLANWLVFVWVLAKLPRRPVGWRSAVKGALAASFGFELLKQAGTIYLTIVTSSPAGAAFGPVIGVLVFANLVAQYLLFITAWTATARENLLRDPPKPPPPAVIRPVVEVRSKPNARTAAGLVGVGFVLGALLLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY35</accession>
    <name>A0A7W7SY35_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myo-inositol-1(Or 4)-monophosphatase</fullName>
            <ecNumber evidence="1">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="28728" checksum="4900CB13C76E6891" modified="2021-06-02" version="1">MTKNPWPVPEPQVSHDVHPALAATARAAARAYQEARQLHARSELREEVAQGADGTPTMRVDAIVEEAVATAARRVGVNLLSEEAGFLDHGSAVTLVVDPVDGSANAALGVPLSCFSGAVVVDDRPVEALTVWFDTGRSWWAKAGEPTPFRTSRRTSLDGAAVCLMRPKRGSTDAWLRVADRADRIRVLCTTCLETMLVAEGAVDAFADTGSDTHRLMDLIAASVIVPAAGGALVDLDGRPLVFDVDLSRRWSGIAAATPQLADELITTILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYG3</accession>
    <name>A0A7W7SYG3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="24153" checksum="F394AA5AE913A6E3" modified="2021-06-02" version="1">MREAYHDQLGQLAEQLADMCAMAGDAMERATAALLGADLGLAERVIGDDLKIDDVRSSIEEQAYALLALQAPVATDLRVVLAVIHAAESVERMGDLALHVAKAARRRHPNPVLSETVQPYFAEMGRIAVELAREATEIIRSRDVERARSLEDADDAMDDLHRHLFTVIMDKEWSHGVASAVDTTLLGRFYERFADHAVSVAKRTVFVVTGRMPGYGGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL3</accession>
    <name>A0A7W7SZL3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="26133" checksum="7982B34475080AE1" modified="2021-06-02" version="1">MPTYRAPKDYLFGQLSASATNSTTTLTSNDFTNLPTTYSSTYVLPLALSDDTLKVYEVVWVTGHASSSNQVTVVRGKEGSTAQTWSSGTRWQCAPMQYDGLGVTSRAGLNADPHVGQRRMLNDEGFVVQSTYAQGWQADVGLANPSEYGKTIAGGAIPTWASVIARGNIVNGTTNGSGQIPVTYTTPFPTATLTVVTTWITGSASCDTRLYPGSQTASGFSVYVVAMATGSTVGSGITATFNYIAHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZV9</accession>
    <name>A0A7W7SZV9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="35999" checksum="BC40CDB6CDB67BBB" modified="2021-06-02" version="1">MTHPGDGPSGWGGQPGQGDWNQQRYGHPQQPAPGGQQGYGQPGYGPAYDQPTYGYDQQGNPGYTQPGYGGQQGYGGYGGLGVFSGGEEPPRKNRTGLWITLGVVVVLLIGGGITAVILTKGDDSQKTAGPDTSQSAPATTTGSAAKPTTSAPPSGTTGTPTTCKAAKADWNCLPVPALSYSYDVPKDWSPKNGTAAVDGIDAKLTGLTVHAVYDCGGNGYNRGGTGGVVVPQTDLNTVAKDFAQKLTKQYYASAPNLEVKVGEPKQVKIPFKKADGSAGEVQGVQVDGTAITSGSECLATKGMVKILVLVGDKGFHVFMANGDLEGGPASPAPVREADLQAMIDSVKPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZW9</accession>
    <name>A0A7W7SZW9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="45994" checksum="420E64888471B6F2" modified="2021-06-02" version="1">MAEVPEETARVAPAVFPKGCLAMRMRDVHGPVFADADFEELFPVRGRPAVSPARLALVSVLQFAEGLTDRQAAHAVRSRLDWKYALSLELTDTGFDFSVLSGFRARLAEADAGRAVFDAVLRAGGAAGLVKSGGRQRTDATHVPAATRDLSRLEFVVGTLRTALDRIAEVAGDWLVTVAAPEWFDRYTAQPEDSRFPSRWAARVRHDDQCGADGMVLLEAAWSAAAPPGLRHLPAVEFLRRTWVQQFRHVEGVVRCRHPQDNPPGLIRLRTPHEPEARTGAKRDLGWSGYKVHLSETCEPDAPYLITHVHTTPAPVTDLAALEDVDAEQIHHARRDHDIDLVGPVGKITNPEQATGGFFDNTRFTVDWERRRAVCPGGHAGVQWRDAQSHCGTPVTRVRFAERHCGPCAPAAPMPGPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZX4</accession>
    <name>A0A7W7SZX4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8037" checksum="FAAAB32763A5D936" modified="2021-06-02" version="1">MTEPDPPVRSGDDQGPPEPTIEGLSLSAIEADLDALMAAKMTELDDMLAGLEDLVVRLEGEITELERPDDDTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T003</accession>
    <name>A0A7W7T003_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36448" checksum="2DCDBF1BF31AEADF" modified="2021-06-02" version="1">MPRIRSRCGECPFGERSRSPTRPTTSTTSARSRRRASSPCVARVGIDSSERTGRPPPAGASNAPISRLTDHHASSLSLRSIDLLHTAHETVRVGRGLGVPMHSPAAATRVRTDRHSHRCEGAELNRPGRARRALVMRPHRPRGTRHHGETIVNRHGKVIDARTRAKHAATADLSQPSPPSTDSRSGSVRSNPRAHMPPAVRVHAMPPAPPGKADSPPTRGPATCGYGAHESDPPCLSPAHRPLEGGADHHCGPANVTHIVVAALICTQSNTAGLHRTSLRSLHLSAGATPGVNFLPNADGVRLRGFLAVRCARLRSGRLGPNADRRLVVDHLIYLDSPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0G7</accession>
    <name>A0A7W7T0G7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030735331" evidence="3">
        <location>
            <begin position="47"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="28636" checksum="2AFF1DED8A02C382" modified="2021-06-02" version="1">MDTTSTRKNTEEGMIMAETLRRLRSWLGLVVAAVLLPVAGVSAAAADPGATIVGGTRASTAQYPWVVYLATTSGYQYCGGTLVAPNKVLTAAHCTEDDVASSVLVVAGRDDKNSSAGTAARVTRIWIHPSFSSVTRGYDVSVLTLDRNLTQATLPVATAADANLYTAGTSTTILGWGTTRAGGQPSRYLLRASVPVTGDQTCSAGYGSQYKPQHMVCAGLPQGGVDTCQGDSGGPLVAGGKLIGVTSFGEGCASARYPGVYARVSSYETEIRQQLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H0</accession>
    <name>A0A7W7T0H0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035930">
        <property type="entry name" value="FomD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159234">
        <property type="entry name" value="SSF159234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="18946" checksum="31F6BFD37AF1996C" modified="2021-06-02" version="1">MGAVITPRLVDVVDTVNAVRSFSPGASRALSECRVEHWGLRLECPTPEDPSVDAEITWLLPDVGVRLTHQRPRSRHARSGPTVITAVRVEVDGRTWRTTDLLLGLAVPGRTTPRIVCAEEFAAAVAGRVLGPEDADQALRTVHRTLEDLSLHRHDIGSWLVHRGIYDTWPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M6</accession>
    <name>A0A7W7T0M6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NitT/TauT family transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031568082" evidence="2">
        <location>
            <begin position="40"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="66"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="342" mass="36063" checksum="30512FC14B262D42" modified="2021-06-02" version="1">MTPRVGRTARTIVGALSALTMLVAVSGCGLLGGSDETPAASGAPTPGKLEKTKIKLGLIPVVDVASVHVAIKKGYFQEEGLEIEPVKVQGGAFAIPSLLKGELDITFGNWVSFFAAESKGAARDVDGLKLINDGYQAKPDMFLIVAKADSPIKAPKDLVGKTIAINTFKNIAELTAKATLEANDVDPSKVNFKELPFGDMEAAVQNGSVDAAFMVEPFISKAQRSIGAVTVLDAASGPTDSIPVAGYGTTGKFAKENPNTIAAFQRAMAKGQRDAADRLTVEPLLVEYVKVDKETASLVHFGEFPVTLDPTRLQRVANLMRTYGLLDKDFDVKPMLLPGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N8</accession>
    <name>A0A7W7T0N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydrolipoamide dehydrogenase</fullName>
            <ecNumber evidence="6">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="349"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="185"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="467" mass="48930" checksum="FC4223942EC81F7B" modified="2021-06-02" version="1">MTRIVIMGGGPAGYEAALVAAQHGAEVTIVEREGLGGACVLYDCVPSKTFIASAGGRSNFRNAGDLGIRTNDTEAAVELPVVHGRVKGLALAQSADVRARLQREGVRIVNGTAKFCDSERGLAQHQVVAETVEGTTEVLPADVVLIATGATPRVLPGAEPDGKRVLTWRDIYDLPELPEHLAVVGSGVTGVEFASAYTELGVKVTLVSSRDRVLPHEDADAAAVLEEVFAERGTAVTKHARAERVDNVGDGVVIHLEDGRTIEASHALMTVGSIPNTADLGLDKIGVELGRGGYLPVDRVSRTNVSGVYAAGDCTGVLLLASVAAMQGRIAMWHALGEGVSPIKLKTVAANVFTNPEIATVGISQQAIDAGEVPARTIMLPLNTNPRAKMQAVRRGFVKLFCRPATGVVIGGVVVAPNASELILPIALSVQNQLTVEDLATTFSVYPSLTGSITEAARQLMRHDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0P0</accession>
    <name>A0A7W7T0P0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="62"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="27728" checksum="BF17300B9BFF824B" modified="2021-06-02" version="1">MSQSLDRALTLVGQLATGPKTLDELSVVIEVHKSTTLRLLRTLESHRFVQRDGVHHYRLGTALFDLANRALEERDVRRTVEPALRDLNARFGYTVHLASYEGGEVIYIDKYDSTHPMRMYSRIGRRAPLHCTGVAKVLLADLPHARRVEIAESIEYTPLTANTITDPRAFLAELDRVREQGYAVDNAEHEDFIHCVAAPIRGPRGEVVAAVSMSVPKVLLDYAGLLAHLPDLLATARAASVECGWTPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R0</accession>
    <name>A0A7W7T0R0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sirohydrochlorin ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="27729" checksum="0B702D554075133E" modified="2021-06-02" version="1">MGVREAVARRSGADRARALRTKWRAASLAAGWVYPADWHLEEVDEVCAAVLADGDPGGALYRLGGARAEAGAGLAETLLDLAALQGVLADGESDVDAVPARLLHATALGWGDVLSRQAADRSSDNPLTGLATGAYLRTRLREVYAEARAGGSLDHVLVLVGLDLTRTSGWSRVVAMTLLADALRTVFDSGETIATVNRSLAAVLLRRDVHLARRLANLKVVIESRLKVDPHVAPTGPAQVWLESLPDTWEEATELLDGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S7</accession>
    <name>A0A7W7T0S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS30 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="158"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="325" mass="35633" checksum="E2BE6CB873D776BC" modified="2021-06-02" version="1">MRRMLTLADREEISRGLVELLEFRDIAARVGRDASVVSREVARHGGRDGYRAVAADAAAGVGRSRPKVMAVEPSARTRSRVWSLLRRGWSPASIAGRLARGHAAGNSGRVSHEAIYQWVYAQPVATLRRELIALRTGRTKRTGPRPAPAPRIREPRYIDDRPEEVEGRAVPGHWEGDPVIGKGGESAVATLVERTSRFLILVPLTGRDSLSVTQAVVAAVGDLPTTVKRSLTWDCGSEMALHRDVTATGLPVFFAHPHSPWERGSNENLSRIVREYLPKGVGITSDPTYLAAIAAEINDRPRKLHDWKKPSEVFTELLEADASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F7</accession>
    <name>A0A7W7T1F7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="24961" checksum="FBBAD3B0C274A36D" modified="2021-06-02" version="1">MVSVLLVEDDPVVRSAVSRALTGMGHAVLPVGTALEALREITSSAFDLVVLDLGLPDMDGADALRMMRGVCDVPVIVATARDDESEIVRLLNAGADDYLVKPFSSEHLAARLSAVLRRARREDSGPEPLRIGELTVDLDRREARLAGRELNLTRKEFDLLAYLAARAGKVVPRAELLANLWNMPGRHDDQTLDVHLSWLRRKLGERAAQPRYLHTVRGVGFKLTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1N6</accession>
    <name>A0A7W7T1N6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR03086 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19287" checksum="057A0C874E2A4967" modified="2021-06-02" version="1">MTEFDARVRRVRTDQWTAPTPCAEWTVHDLVNHLVHEQLWAPELLAGCTVDQVGDRFDGDQLGDDPVHSWVLAAAAAREAWISPTALLRTVHLSAGKAPAPEYGWQMTLDLAVHAWDLARAIGVDERLDPDLAGTVLDYVDGHTGELADSGLFDDPVPVADDVDPQGRLLALLGRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Q3</accession>
    <name>A0A7W7T1Q3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="442" mass="46280" checksum="DD2A69BAFECA3EB5" modified="2021-06-02" version="1">MPVWLPLVSVGLLGSQWEYTPLVGVPILFAYALYTRGARLALATLAYLVAALVGQPGYADLVAILAGFLLAAHDLHARRPGRWFVLLALGLGVLAVSAYDTGSGSFDYAPAVSFAEAGPHVVHPGVALLWALGLALAIWGGWHRDVVVVVTAALYLVVTIAHSATTSFTEDWSERAVHAAFHYDGAGLPFGAGRFPELVLLAGAVLAYTRPGRRRAPRPWALVAVAGLLGSLWEYGPLVALAVLLVAAGYLYSLPLGLAAAAYGIAVFVAPPGVDVMVAVAVAGLLVAREVNARRPGDWLPLAVVGATLFLSMTYTGVHRGWLTDGLPEVLPGESGGPALVIVGTLFLLGWAMYDRLALVGVVAVAYLTAGLYRFGDRQAGLQFLSQEQLRMLPAHGPLWVLGPELLILAGAAVAFARTGRTRPDVRTVGRPVGTPGPPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1W1</accession>
    <name>A0A7W7T1W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine catabolism regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="21"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="365"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="45140" checksum="5BC283D0FC3FAFF0" modified="2021-06-02" version="1">MPLTLATLVRETGLTIRVAFGLDRVVSWVHSTELADPTPFLEGGELLLTTGLAAGPYDAYVRRLVDADAVGLGFGTGLSHDRVPDGLVRAAAEIGFPLLEVPRAVPFIAITKAVSAAVAADEYAAVERISVARHRLTRAAVGPRGAVAVVRRLAALLDAGVALLDEAGHALHVVGHVPPVDAEVRRISGGRASAVWQADGTDVALQVLGRGGFLAVATGRPLDLADRDIVDTAASLLTLALVRTDEVDAVRAELRTARFRLLLAGIAVDGVPEPPFRVFVLRHDVADPPGFWARIDGRTVVVAKDCALPAAASSECDDVARGYREASRAWQEGVDRFEDVAGSGLLAPDADAFAEALLAPLDAVLRDSLRVWLGCHGQWDPAAARLGVHRHTMRNRMRRVEELLGRSLDSAGLRAELWLALHAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Y8</accession>
    <name>A0A7W7T1Y8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteinyl-tRNA synthetase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016062">
        <property type="entry name" value="TM1410-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35882:SF1">
        <property type="entry name" value="PTHR35882:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01545">
        <property type="entry name" value="THEMAYE10DUF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_114" evidence="1">
        <location>
            <begin position="27"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="288" mass="32118" checksum="24766CBF3E258E58" modified="2021-06-02" version="1">MVVFLLISLSGLAGCSRESPPVVPGGFVYQLQGYQDERLGELAGTSARYAVVDLARDAGESYFSAEEIGALKGSGKIVLAYFEIGSIEDFRPDFASTGAGLTLNEWETWPGEFFVRYWEERWWELGIKPRLDRALQAGFDGVYLDTPLAYEEIDLALVPGLDREVLGRRMVDLIMRISSYAKGARSDFRVYPQNSPELVRYSGFLDAVDGIGIEELFFEATDEPCTADYCATNLAATREVRRAGKTVLAVDYAVRPDNMAEACRRYREEGFEGYVAVRALDRISAQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T203</accession>
    <name>A0A7W7T203_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20941" checksum="2BE41FA679DD1A89" modified="2021-06-02" version="1">MVRRSVALDAYAPACRKHMTAAEREEDDTNPLWSDEGQVRWLLARRPEGGELLTTAAIAEQLKLQPGTVSRALERLRARGAVVAGSEGERDAWADPVLFERWRERVHREDARVRAELEVVRARVEKRNDALGSIASRLREVVAGRDVGVSLVGGTPQLSEVPAEHALVLSVDDPEVAEWLVDRLAGKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T269</accession>
    <name>A0A7W7T269_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21515" checksum="9D11AC80F3D09FCB" modified="2021-06-02" version="1">MIRYLGSTKNLVGCVGGLVGLVLHLTGVVGALWPVVVAALYAVGALLAPPEKVRLVREDAATEASRVRTGLAELVGQVEAHASRLPESTMDSVRRVAGVLDDLLGRADRLAADPDLRHTVVRLAGTDLPLSVQTYLNLPWWLAVKRRADGEPSPAEELVGQLALLDAQAHDVAERLFAADRDRQSDHTRYLRDRDGYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T285</accession>
    <name>A0A7W7T285_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="509" mass="53697" checksum="2CC2A8F9D611E180" modified="2021-06-02" version="1">MTAADAARILVVDDTEASRYIRASWLRRGGHAVTEAVTGGEALALLAEREFDLVVLDVDLPDMSGFDVAERIKSEPRTAAVPVVHVSAAFRQAEDRITGLNRGADAYLTEPVEPGELLATVEAALRYYRARALAERLADRLAKLTTATLRINAATTFDDLVSAAAAGTATVLDTEATVLVTTPTGTSRLGTVTGAGATPTVRRGDPALLDALPPDGTTVLDPPWRPGVPVVVAGGSPRRTPIGIAVDPAAVVTDEDRNLLLQLAQATALAAEGLRAYAEEHTLALTLQRSLLPRRLPAIPSLPMTARYAPASAHAEIGGDFYEVTALGDRLLIAIGDVCGHSLAAATIMGEVRHALRAYAVEEHDPATILRKLDAMLQRFHSTKGLTTMCLLLVDPADGTALVANAGHVPPLVVDDEGARYLAVRGPILGIGLPRPPATPVTLAPGALVLLTTDGLVEHSGADLDDGMDLLLAAVSRDEDMDLLCDRLLETFGRDKKDDIALLVFRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T292</accession>
    <name>A0A7W7T292_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1092" mass="116553" checksum="0F7E03349EFC4BED" modified="2021-06-02" version="1">MTTAGNTDPVDRVPARIAWTASPSITLTYLADDDALLVDVLPGTSRAEVDRHGGLSIGLDGGDPLALPVCVCLVGFASTRGPAARLAREYLGEEIWRHATGLPTDADSDTWFVLTESAKTDALARWAAFAHREFGDVAGLRTLALPAAGKVRDVFISHAQEDRAVMTAFAEQLAEAGLDVFMDDTSRPRPDALASAKVFLAYSSATHPRLPAGLWSLLAAHRAAGAHGHRVLTVDPDTAPRGEVDLLHRVRESVALVDAPFGPTGDDVGADGFVGRLAELVRVHEALRDDGSVVLVRGADGIGKTSLVERYAALFRAVFPGGVHWTGPLGAGRDDAETLARYHAEVRRVAVALRIAVEGVERRRLRRLVADHFDALGRRVLWVVDDVPPDLAPETLDQLVIPSRHVCTVLTGRGVPGRWTWSTVDLDPLSTVDAELLAVHALPLPRAALDRSRHTARSRHAAIGTDTGSHDTGPAGHATGNPMSASTVHRAVPVRPRTTTTPRRKPFAGPTPHHPRFTPAPTVFDLAGGHALALTVAAAAVRVDPDAAAVAPAGDPRSLVDFLVAHVLARVGDGARTVLRLAALLDAAPLPEPLIVAVVDVVAPGTDVPDALDGLAVLRLARQSDGGWCVHPMVGAAVVRVDSPADLAAVARAAAAVLSRLLTTPDVVELWYHARALAAVDLVPDTGRAGLLRLVSRWHERIGEPGVAAAMLDDASAVVPHDPRDLVDAARVKIAAGAFEAAGADARRAVALAVDDRTRYVARALAARALDHLGHHPDAEPSAPGGPPTCLSTVDSFLAALAAAVSRRLRGRPVEGIALLAPVLERAPGEPAWRDRRAELRLELARLHLQAGQPATAHRLTEEVLADHAAAGLDLHDRCLEAKGLRAEATLALDLADVDPRPDHWEHRLDELHARYRRTLGEEDPLTLTAAVHRDRALVTLGKPGQALDTLIRTEELVARHLGEDHALRYRTRLVIGLACGRLRQFPRQRAILDGLLRRQVAALGAAHPDTLEAKVDLGIALAHTGDPTRARALVDDALSHLRDVLDLATDRRASFGQMLLQLFPKRVALFDQVLDRHRGETGWGHDSRHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z1</accession>
    <name>A0A7W7T2Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="15156" checksum="C83D02E76F05B294" modified="2021-06-02" version="1">MLADWSQRWIDRNFPLDYTLKSLEKILDGPGYHAVRDLRRVLKNAAYLVFGAMLHTLNATDPDTAARHPLHERCAAIVESMIRELHAALDPVVARVQADLPDDHRDLLHHEYDRWNDIHTWDLINAGDPCGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z7</accession>
    <name>A0A7W7T2Z7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4865" checksum="7154E4C6F0704762" modified="2021-06-02" version="1">MISGATLNAGRCPQRIGQRNVSWYYPIADSLAYYGPRYGVVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T335</accession>
    <name>A0A7W7T335_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="191" mass="21367" checksum="31C38C07BF33D2F0" modified="2021-06-02" version="1">MSRTGLAADLHRYLQESRDRLLAALDGLSEYDIRRPATPSGTNLLGLVKHLAGIEFGYLGDSVGRPAPVRLPWVEDGSIWDSADMWATAEETREDLVALYRRAWRHTDESLDLLGLDAPAEVSWWAEDKRRTTLGSLLVRTTAETAQHAGHADIVREMIDGRGGADHDDLGDADWWTGYVDRIQRAADHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T353</accession>
    <name>A0A7W7T353_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16526" checksum="2A0EF26FD354F843" modified="2021-06-02" version="1">MRRRTIALDQLDELVDESPKRERVELRTEFAFELPRGYVDQSGTVHRHGRMRLATARDELRPQIDLRVKENPGYLGVVLLSQVITELGTVTEIHPGVVELMYATDIAFLQDFYRRINSEGHTRAGVSCPACGTAFEVDLAGGRLGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M9</accession>
    <name>A0A7W7T3M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030808830" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="7212" checksum="D7FCEEE388F02A19" modified="2021-06-02" version="1">MRIRGAHVLTLAMKTVRAILAPDTPLGAALTATAIPVLATARHLTRTATELLRRCPPKRRTRDTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T489</accession>
    <name>A0A7W7T489_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like" evidence="2">
        <location>
            <begin position="628"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1031" mass="112868" checksum="903853EC3995ECCC" modified="2021-06-02" version="1">MSVFDLPRLHFAGTATTRLPTGPKSGLVDLATNTALTASGPADMSTSEYHAYLDGHSPRFDADGRPCDDGPFTTTKGWNFAGNGHFAVDARIVGVELAPGDLDVSDPVVGRSVDLWGHYNPYLATTVNRARVFDVDPASDWTTTLMVGQFCFGRAGRSHDAGYLFSGGVSGFAPPRWHHLRYVRDVGDHPFAPHLRRSVVHQFVTSRDDPLWRWPAAEPRSPAVAALRELTDSTADGLVVQFTLGSMATPRAPGVPNHWELRGTIAPWHADESRTYPAGRLLVPTRTGALHTLTVDVTPTHATFNLVNAVPLTTRAPRPGPGPTHAPGPRLDLGDLELRGADGRLVAVLPRDAYREPRPDGGLVVVPVVDAGAADQALRIVGGGTVLLAEREVNVQADDACLFLEHSGDEDVEVRTYLRGRPSAHEVHIGQYVNAKATPFDRTSDVVHAKSVLHTDERGRGTLTLHGARAGTARILLSPTAEVPDLDYDHDDALGFWPGAGWLAVRVLPDDRRLDDIADEDVTFDVLHREVFAYYEHLYSFMRDEVFSLDDAFRVHTYARLIWQMSDPANKAKTYYMPPTRDLTAPQARLLLAFLRKQHEADATAPVVGSVAATGPRIVNRGDLLRALHDAATIELAVMLQYLYAAFSLPTYGAARDLVRRGEWRPEHLGLVCGDGGETRDGGIRGTLLAVAREEMIHFLLVNNVIMAIGEPFHVPDLDFGTVNSRLPIPLDFALEPLGIGSVQRFIAIERPDDGTTHPYGDDRPYGSLSELYADIREGLCRVPDLFLVEKGRGGGEHHLFLRESINAVHPDYQLEVDDLASALFAIDVVTEQGEGNVLTAADGGQSHFATFLRISDLLMTETLGAERRGKVPWTPAYPVVRNPTLRPGNPATEPVSDPDARTVLTLFNKSYFMMFQLMLHHFGHQPDASLRRSDLMNMAIEIMTGVLRPTAEVLVRLPSGRRGRTAGPSFELIGTPGLIPRPDVAWRSLALRFDHLAAATRRCGLIPDSAVDTLGFLAAHFHSRPRRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G7</accession>
    <name>A0A7W7T4G7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASC-1-like (ASCH) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="379"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="488" mass="54767" checksum="BC54B2E9B8369CF2" modified="2021-06-02" version="1">MSRNGKPALLVSPNSILANALLRSIDLLRPRVLAARPKRIEFVVGTQINGAPHLGTNLVQIAAFLLAKIARREFSIDTVVRFGALDNAPHTVDLDPETHHAYQQTYFHALGKDQIGELIEGYYQAFFRSLSEATDTEYAVETYTDQQATPGFRAEFLRTLERLEDIRWWMAPSHGLVHIRVPCPDCGWAEKRAERTKLAHLDEDGATFTAVCMDHGGYEVHIDPEDDVPYLDLATLYRNLVKERAFGRDTDVLHVMLKGGDWTFGCQLVDGALGALGTPAAQMPIRVFTPQVLAPTGAKLSKSLLREQGRAALPPDVEPWMLDTTAWPGTVDDYVDALVWLVGELLKDPKHFFRSFTVKELGRLMIQRPTEPGVRAHEMGIYKRYFDLIATGRKTTEIRVNDSSRRNIKPGSLIRFNCQGDNVLTRVTKVNRYTSFEEMFDREPVASVNPTATREDQLANIRQIYPPEREALGVVAIGIELVEPPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S9</accession>
    <name>A0A7W7T4S9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002669</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="515" mass="53510" checksum="492FBC64C933527F" modified="2021-06-02" version="1">MTVIPARGQGIALAALCLSALMFGLEISSVPVILSTIGEVLHGDFTDLQWTMNAYTIACTTVLMASGALADRFGRKRLLVIAVATFGATSLLCGLAQDVTVLIAGRALQGMSGGTMLICQVAILSQQFPAGRQRTRAFGTWGIVFGTGLGFGPVIGGGLVALSNWRWVFLVHTVLAAVTLALTMRGVRESRDPTGNRLDIGGIVTLSLAVFGLVFFITQGPGLGLDSVLTLGSLVLAAAFGVAFVVIERSGSHPMVDFSVFRIRAFSGALLGSAAMNFSYWPLMIYLPIHLQRGLGYGTAATGVCLLAYTIPTLALPPVAERLAVKYRPGVIIPVGLYLIGLGFLLLYLGSGVADANWVTILPGSVLAGVGLGLANTPVTNTTTGSVPAERSGMASGIDMSARMISLAVNIALMGLILTLGISARLNDHPQLSGAQARALAEHVANGADLAALTHALPALPDPESTEALVRSALTHGFGLITLYGGIAASALATAGLVVFRVRRRTRVKDRHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V2</accession>
    <name>A0A7W7T4V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="137"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="708" mass="77688" checksum="4B471C0F97E5CAFA" modified="2021-06-02" version="1">MTHQHAVAVAGSMVVQAGGDVHLAVRAETFVPRQLPARPPHFVGRADDLHALDDALLPTSAGTVVVTSVGGAGGIGKTSLVLHWAHSRSDEFPDGQLYVDLRGFSPDSEPLAAATAARGFLCALGVAPATIPVDEHAQTAQFRTLAARRRMLVVLDNAADSDQVAPLLPASSTCLVVITSRRRPGGLINSVGARHLVLDALPDREALALLAARLGSARLAREPEAVQALLRGCGGMPLALSVVAGRAAAHSRLPLSTVVDELREAGLDGLEDGEPGTDVKTVLSWSYRALDPRHAQMFALLGLAPGPDVTVEAAAALAGIPVRDARAVLRGLEQSSLLTRGDADRYRAHDLVHALAWDRAQHDVPEQVRDAARDRLADFYTRTAHAARRLLEPHDIHIELPARLRSCGPKPLSDRTDALAWFAAEHRCLWHLLVVPRSSAAWHRWQLAWAMSAYHRLSGLLGDDVRAWVHAEAAADMWPDPVVDALVHRHLGHAYVQVGEFEQARHHLVRALHEAERTDDAGSQGFVHRIASVMCEYQGLLEPAYDHAREAVALFRRTGEPLWEADAVNAAGWCAALLGRMNEAERLSREAYPVLSRYDPRGAADTLDTLGFIAHRNHRDHDALDLFRSALALYRELGDVYHVPDTLDRTGRVLHALGRTDDADRMWRQALALYRDQLRVTDARRVRRQLEGRKSDRLSEHTWPYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V3</accession>
    <name>A0A7W7T4V3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA ligase D-like protein (Predicted polymerase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="33230" checksum="36DD4570853786EC" modified="2021-06-02" version="1">MEFSNLDQALFDGSGATKGDLVAYLDAVHARLVPALAGRALSVVRVRPGQEPFMQKNLPKYTPARVPSVTLWAESSRRDIRYALCDDRETLLWFANQRAVEYHVTLSRAAAPDRPTHLVLDLDPPEGAGFDVVVRAAAPVRRALADAGLSGLVKTSGSKGVHVFVPVDASDDDAAAATRALAVRAERLDPDVATTAFIREDRGGRVFLDSTRAYGATVAAVYSPRIRPGVPVSFPVDWDDLGTVSPADFTIRTVPGLLGDGDPWADRMPTPQRLPEDLVAEGHTIPVARVQAMHEGKRRARARRADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y1</accession>
    <name>A0A7W7T4Y1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GrpB-like predicted nucleotidyltransferase (UPF0157 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="PTHR34822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="22238" checksum="B8AC247A9E3E6003" modified="2021-06-02" version="1">MPAFEEITRHHDENPDENPWVLGPPAPETVALVPYDPEWPRRYEALAADIRSALGDVVLDLDHIGSTSVEGLAAKDVVDIDLTVADPRDEDAYVPALERLGYLLVIREPSFHEHRALRLDRPRANLHVFGPDCPESIRHRMFRDWLRTHPDDRGRYEEAKRAAIPGGGTVMAYNLRKETVIREIYDRLFRAAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T511</accession>
    <name>A0A7W7T511_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_004029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4966670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="45546" checksum="E1C2596347FF14DB" modified="2021-06-02" version="1">MDGIWWDLALVGVLVLVNAVFSGSEMALVSLREGQVRALEREDGHRARTLVRLARDPNRFLATIQIGITLAGFLASAAAAVSLAAPLVPLLSFLGGAANPVAVALVTMVLTFFTLVLGELAPKRLAMQYALPWALLAARPLDVLSTVSRPVVWLLSTSTDVVVRVFGGNPEADGDQLSPEELRDLVDTQRHLNQEQREIITGALEIHERRLREVLVPRREVFTLAADLPVARARAELAASGFSRAPVVRTGHLDDVIGVVHLRDLLADDTTLERASRDALVLPDSVRVADALRHFKSEREQLGLVVDEHGAVGGIVTFEDLLEEVVGEIYDESDRDVAAVRSEADGSLVLPGTFPMHDLPDVGVDLPDAPDGDYTTIAGLVLVELGRIPEGPGDEVTVSAWRVEVLDVAHHAITSVRLTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L1</accession>
    <name>A0A7W7T5L1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13800" checksum="CAFF114285C0AD8F" modified="2021-06-02" version="1">MPYLGGTFGLLMLGLWLFCVVDVITTDDGDTRHLPKVAWLLIVLFFPLVGSIAWLVAGRPPRVGVRSRAYEREARSFPEYDRPGRFAAADRESDEEFLRRCRERAEEQRRKARESRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S7</accession>
    <name>A0A7W7T5S7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031321947" evidence="1">
        <location>
            <begin position="39"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="20884" checksum="837055174ED81E7E" modified="2021-06-02" version="1">MSAVPASRRSRRRFAFVAVLSGLAGSVLLALSLTGTLAAFTAAITNSTDTVSTGSLIMRETDGSNTCTSNSSSTNSATCATINKYTGSVLAPGGSATKTVTLANDGTGTPATFTLTPGTCSQSGSVSGITPANDFCTQVTLKVYVGATATGSPIYNGTLAAFTTPLSLTPLAASATQPYTFQVSLPSSLGNSYQGLTASQALTWTFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T7</accession>
    <name>A0A7W7T5T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2'-5' RNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22798" checksum="266904EAC58F61C4" modified="2021-06-02" version="1">MTGLEPMRDHWWWRPGWCVGRSFYTWHVTFADQPGAGRLVADYAPVLAGLPQLDPVPARWLHLTLQGVGFTDETDRAEVDRVVEAARGRCAGLEPFTVTIGSAHVDPETIQMPVRPLEPLAALRRAIRAAIGDVRGPENVPEPEAGFRAHVSLGYCNTAGPAEPIAEALEVHSRHSAEVVVSSVSSIDFNRDRKAYEWTDVATVRLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T655</accession>
    <name>A0A7W7T655_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA A-37 threonylcarbamoyl transferase component Bud32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="69"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="34012" checksum="257C3DBA12B50A98" modified="2021-06-02" version="1">MLSGTVFQDRRTTGVERLRGGSKKGVYRVALDGPGPSSVIVYRWTAEENYWPDAGDVDDTDPLGPASGPELFLAAWRRLDRLGVRVPRVLDTDGAEWAVVEDVTGGTLEALLARDPGRGAAAVAELGRALDAMHADHAPRCGRVDRLDRTPDIACEQRVYDRALDDLAEAARRDDRIAAARDRFAHRLAELRDRVAPRSQVGLIHGELGPDHVLLDADDRPVLIDIEGLMHFDVEWEHVFLRLRFRDHYPPLARPGLDPDRLALYSLSLHLNLVAGPLRLLDGDFPDRAAMLFIAERNLEAALALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T666</accession>
    <name>A0A7W7T666_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="22812" checksum="B1B510BD922A4BA8" modified="2021-06-02" version="1">MTTTVTDTHSRTLHVPYITAWSAEQTEPHDLVALPGNTGIGYRDERPRDRDRDGVLWRRVPLARGQGKPLFGVVHSPRQRRAMRKLLCQVCAHPADTDPDGTLFALPDNRTDWADWPEGMACTEPPVCADCLTLSTRLCPALRRGHAVVRVRNAPIVGVHGALHVASPNGMRAWKPTIATFDDPALSWVLASHLVRELRDVTLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D1</accession>
    <name>A0A7W7T6D1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22814" checksum="1512085CB65276D5" modified="2021-06-02" version="1">MTLRLVVVDDHPVVRDGLRGMLGTQPDFEIVGEAAGGLEALTVVEAVVPDVVLTDLRMPEPSGGTLIRLLRERVPSVRVLVLTTHDTDSDVLPAVEAGAIGYLLKDAPREELFRAVRAAARGETVLAPSVAALLLERVRPKPTLTRARLSARELDVLALIAEGRTNREAAAELFISEATVKTHLLHIYAKLEVPDRASAVAAAYRRGILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6G0</accession>
    <name>A0A7W7T6G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="217" mass="23158" checksum="C80307804289CBC3" modified="2021-06-02" version="1">MGAMGQSGNGPGAIAPDGSPVGFFARSPARREPEVVHRAVAEGAAILELGCGAGRVTHPLLALGHPVVGVDESPEMLAHVRTEVVCAPIEELRLDRRFDAVVLGSFLINSAGPALGRRFLDTARAHVRDDGVVLVERAVPSHGDSDGGEVSVGEIRRVGDDLIVATLEYRLDGQVWTHRITNHLLDDDALAACLRAADLELESFLTEDRSWVRARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6G3</accession>
    <name>A0A7W7T6G3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="92"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="43613" checksum="B7F4C5C10803D29D" modified="2021-06-02" version="1">MNTAPDSAPNDDFAHPGPLRQEGTPVTHDATHQPAAESSAASSELTAAAVGDEPTQRIPRALIAALDTPPTAVDNPVDSGEQNGSAEPRAVSVWTTAQSSPAAQRKNKYTPESTAHPAKMLPEVVRHAVTHYTKPGELVLDPMCGIGTTLVEAVRLGRRAVGVEYEPHWVEVANANLDVAREQGVGGEKGIDARVFHGDARQLVTLLPPEYVGQAALVVTSPPYGPSTHGQVSVAPGAGVQKYHHLYGNTLDRGNLANIGHHRLLAGFTRILAALRTFLRPGGHIAITIRPWREHAELIDLPSQILACGRAAGLIPVERNVALLARAAETDLVARGSFFQRDFIRKQREAGLPLHLIAHEDVLVFRTTLHKSAGSTAAGTSAEDVVDLAQYRSRRSATAASSSAGERGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6T6</accession>
    <name>A0A7W7T6T6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyphosphate glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.63" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047330">
        <property type="term" value="F:polyphosphate-glucose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="253" mass="26149" checksum="299AEAF5942258EF" modified="2021-06-02" version="1">MGSSRGFGVDIGGSGIKGGLVDLETGTLDGERLRVTTPQPSTPDAVADVVAEIVAKFDWTGPVGVTLPCVVKHGVAHTAANVDKGWIGTDAAALFARRLGRPTEDVVVLNDADAAGLAEMRFGSGVGRAGTVVLLTFGTGIGSALFLDGRLVPNTEFGHLEVDGHDAEKRAAASVKEDRNLSWAEWTPLVSRYLSVLENLIWPDLVIAGGGVSKKAEKWLPLLEARTEVVAAALKNDAGIVGAAVAAAHGTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z5</accession>
    <name>A0A7W7T6Z5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SARP family transcriptional activator/Tfp pilus assembly protein PilF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="682"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="980" mass="104126" checksum="85C86B9B7FE2EB10" modified="2021-06-02" version="1">MASGPWFGLLGPLQVRLDDRLVPVRAGKHRALLAALLLRAGRVVPVGDLVAFLWGQAPPARTRGTLQTYVMRLRQLLGDPSLIRTTADGYRMVVPPERVDVHRFTTTAARASAAARAGDLGTAADLFAEALGLWRGQALADVPSSALRDDEVPRLAERLMIAHEERNDVELALGRHERLVPVLRGLTADHPLRERFWAQLMLALHRGSRQAEALEAFRRADHVLGEQLGVEPGDELRGLHQKILVGDPGLALPRRGRDPDVPRGLPPDVPGFVGRAAAVDRITRLIAPDGSRTAVPIVVVAGVAGVGKTALVTHVAHRLRDRFPDGLLYADLRGYTAGPPAETIDVLSRFLRALGVPPERIPGDVDECGSLFRSLLAQRRMLIVLDNAAAPDRVRPLLPGVAACPVLVTSRSDLRGLIAVDGARPVPLDVLTPAEAQTLLGRSGPAAAELARRCGHLPLTLGIAAASIGDEPVGHYLAALGDRTPARLAHERQSPATRRLFGLLGVVPGGDFDAQAAANLADVPVHEAAESLDRLAAVRLLVRHGDRYGFHDELARFARESEVADGAAARVRLLEYYAATVDRCAEVLYPDLVRLPAPERRHPRVPAVDTPAHARAWLDAELHNLTSAIRSAAEHGPAALSWRLADGLRGYLWIGRHVAEWLCSAHYGLVAAHDQRDRAGEAAMHRNLGTLHRRLGDFGTSISHYTRAVELHRLDGDRDAEAGVRAGLGLVRLEAGDLAAARDELEACLALQRETGGARSGEAGVLVGLGALAVETGEPAEAVVLLTEALSISTAHGLRVAGISARTLLGLALHLTGGNGDEHLAEALRSSVASGFTDAAARVLETTAYVRLRAGDHGAALSLADRALTELRDGADQRITTDVLTVMAAANRGLGALDLADAQYQQASTKARAIGYRAGLARALSGLAGLRRVQGELAESLMLADQAAALTAELGLCLPAELASPPLGHPETHTQAPPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z9</accession>
    <name>A0A7W7T6Z9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">F4559_005091</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="264"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4967732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="41554" checksum="141A924F84731795" modified="2021-06-02" version="1">MSGGKPDGLPSEAELADMDRDELVKLGTAIDGVELVHYEERWPVKGTRAERRAERTVALWFTIAALAGLAFLGAFLFWPWKYEAPHTDEHILYSLYTPLIGFTLGLSILALGVGALLYTKKFIPEELAVQQRHDGGSPEIDKATVLAELADAGVRSTIGRRSLIKRTAGLGAGVFGLGVLAVPLGALVKNPWQDSETKNSLWHTGWKAENGEKVYLRRHTGRFHDVELIRPEDLAAGGFETVFPFRESERDDEEALVAALKRADNPVMLIRLRPGQEVVKRDGQEEFNYGDFYAYSKICTHLGCPTSLYEQQTGLLLCPCHQSQFDVFHYGKPRFGPATRALPQLPITVDEDGYLIARGDFIEAVGPAFWERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T762</accession>
    <name>A0A7W7T762_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="8961" checksum="25379AAC0327C655" modified="2021-06-02" version="1">MKAILFGAAVGYVLGARAGRRRYEQIVRLYRAVADHPAVRGATDAVRAKVGEKTGFGRPPRRESFTVPDSNGRPDPVIPRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E7</accession>
    <name>A0A7W7T7E7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APA family basic amino acid/polyamine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="480" mass="50630" checksum="CD0CA561751767C0" modified="2021-06-02" version="1">MTTHPGLGGGRGVFRRKPIDEIVSDAPSGSAGLTRTLGLWQLTAIGVGGIIGAGIFSLAGAVANKTAGPAVLISFLVAGIASAAAAFSYAEFAGLIPRAGSAYTYGYAVLGEIVGWFIGWDLLLEYTAIVAVVAIGISGYFTELLDLVGVRLPLWLQGAPGTEGSDVAAGSYQVNLFAVVLCLAIAFVLNLGMKNAARFETVLVYLKVAVVLLVIVVGVFHIDTGNYDPFLPFGLSGAFAGAATVFFAVFGYDAMSTAAEESTESRRHMPKAIVYSLAISMVLYVLACLVLTGMVDYRAIDAESAFATAFADIGLPALGIVISVGAVLGITTVLFTFMMGAARVGYSMSRDGLLPAWFGRTHPVRHVPTRTTWVLGIASAVIAGFLPIAEAAELTNIGILLAFVVVCVAVIVLRYRRPDLPRTFRTPGMPVVPVIGIVFSLWLITFLTAHTWLRFAVWFAVGLVVYLLYGRRHSTLSSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7R0</accession>
    <name>A0A7W7T7R0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="131" mass="13753" checksum="69D7D0F8F02B9BD0" modified="2021-06-02" version="1">MANVEVQRVGEHEFEATNGRGARVRIGRRDAADAFSPVELLLAAAAGCAVITAESLVTRRVDGGISARADDVRPGGSGDLTSVPVTLDYDVSVLDDEQRQALAAAVHRAVEKLCTVSRALHSPVDASLHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7T0</accession>
    <name>A0A7W7T7T0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="3">APS reductase</shortName>
            <ecNumber evidence="3">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysH</name>
        <name evidence="6" type="ORF">F4559_005245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="3">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="5">
        <location>
            <begin position="44"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="233" mass="25234" checksum="A8C033465005A83A" modified="2021-06-02" version="1">MTAPSRVEELKVIAEAASVELADASADEALAWTARTFGESWIVASNMQDAVLIDLATKVKSDIDVLFLETGYHFAETIGTRDAVDLVYPDVHIVNAAAEQSVAEQEAEFGLLNQTDPGRCCRLRKVIPLQATLRNYDAWVTGVRRVDAPTRATTPIVQWDERNGLVKINPIAAWSDDEFNAYIADRGILENPLVQAGYPSIGCAPCTAKPLPGADPRSGRWAGQAKTECGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z6</accession>
    <name>A0A7W7T7Z6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="7"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="501" mass="52029" checksum="560306F1FEB9825E" modified="2021-06-02" version="1">MRSRRLAVGAGAGAVLLGALDAYVVVGVLIDMVRDLGIPVNHLERATPVVTGYLLGYVAGMPLLGRLSDRFGRRVVLHVGLLGFALGSVVTALAPGLEVLVVGRVVQGLAGGALLPVTMALVADLWEERRRAAALGVVGAAQELGSVLGTLYGVGVAGLFNAWAFFSALEPQSWRWVFWVNLPLALIASVVVQVSVPGGGGRRVRLDLVGGGLLAASLALLVVGLYNPDPEHSVLPSWGPYVLLAGVAVFGAFLWWERRASVRLLDPVGVAFRPFVACLAVSFAAGAALLVTLVDVELFAQTVLLESAGDAVLVLARFLIALPVGAVLGGWVASRVGDRWPAVVGLLVACGAYVLIARWPADVASGVVDRDLAIAGFGLGLVIAPVSAAVLRVVPAAEHGVASAFVVVARMTGMLVGVAGVTAWGLHRFRELTAGLATPLPFGVAEAEFKAQVEVYRRQLTEALLTEYHEMFLITAGICLVGAVLALGLPGRSRESSTQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8H9</accession>
    <name>A0A7W7T8H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025828">
        <property type="entry name" value="Put_sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13796">
        <property type="entry name" value="Sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Sensor" evidence="3">
        <location>
            <begin position="33"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="45099" checksum="A4B4E3CA9670C351" modified="2021-06-02" version="1">MNDTEIVRGVKARLRTAILAPTRIPLALLGLPLVPLQLLPFPLVLITIGVVLLPLITKVVRAYANRYRRLAGKVLGEEIPVPYRTPTSTGPVARVRAIATDPATWRDLAFLPVNAIVTVVCSLMPLVLWTSGVLGFLMPFLWAAGADGLEYSAIDETTPGNILLAPLLGTLYLSLAWWLTPVFGRLHAQVTRRLLGPTANSALAARVRVLADSRADTVDAQAAELRRIERDLHDGAQARLVALGMSLGMAEDLITRDPEAAARLLTEARQSSSQALSELRDLVRGIHPPVLADRGLDGALRALALASPLPVEVDIVLDGRPEAPVESAAYFAVAETLTNAAKHSGAAGAWLRVRHEDDRLTLMIGDDGRGGAVATENGGLRGIERRLAAFDGTLGIASPAGGPTIVTMELPCVLSSGKTSSSSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8J2</accession>
    <name>A0A7W7T8J2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cys_rich_CPCC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025983">
        <property type="entry name" value="Cys_rich_CPCC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14206">
        <property type="entry name" value="Cys_rich_CPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cys_rich_CPCC" evidence="2">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12506" checksum="CAED08991CC45772" modified="2021-06-02" version="1">MRYEDLPYPGVHVPRTESENSPPDKSRYYASYLDMRDVKAPKGGGPYTCPCCGHPTLDARAEYDICNECGWEDDGQDDHDSAMVRGGPNGSLSLDDARADYIASGGVRGNHVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T929</accession>
    <name>A0A7W7T929_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="27897" checksum="D89382B8C0633747" modified="2021-06-02" version="1">MDSFVALGDSFTEGLDDPGADGAYVGWADRLAEVMAATRPGFRYANLAVRGKMLQEIVREQVPLATSLKPALATFCGGGNDLLVPGSDPDALAEVYEIAVAELRAAGAEVVIFTGFDPRHTPLLRSLRGKIAIYNSHLWSVAERYHCRVVDLWSMAVLHDRRAWSEDRLHLSTEGHRRVAARTAEVLGLQPVEPWDTPWPPAGVEDWISQRRQDLKWAREHVMPWIARRLRGESMGDGVAPKRPELLPLCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9H3</accession>
    <name>A0A7W7T9H3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease SbcC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="519"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="955" mass="105265" checksum="37DBF019524F92D8" modified="2021-06-02" version="1">MKLHRLVVSGFGPYAGREEVDFDLLGADGLFLLHGDTGAGKTTLLDAVAFALFGRVPGARNDVKRLRCDYADRDTRTVVELELTVRGRRFRLVRSPEYERPKKRGDGFTRQQAQVSLTWLAGWSGEGHTRIDEVAREVESLLGMTADQFFQVVLLPQGEFARFLRADTGEREKVLEKLFGTDRFQAVENWFVERRKERGRAVKALAQEARELGVRLAETAGEEPPEDSGDEEWLSSVLKRLVEERDAAGLWARQVAAARGSAQKAWQEARVAAERSARVRAASATVARCDEQEPQRLEWVRERNVARRALAVVPAYEVERRFARDLERTRASEAAAAVIGYEGTDPRADGERYREVAGGLAALAEEADRQRADRERVERLTARLTGLSGQLAVVVRALDEAPDRVTAAQALVEESVVAQARSAETTARAQAARELPDALERGRQVDEERRAAVDAHQLARDRWQAVRARRLEQMAVELAEALRPDEACPVCGSAQHPAPAQPVLDAVTAADEEAAAGREQRAQERRTAVERAAQQAEARVAALREVVGDREVEDILAEHREVETLARQRAERENSLRVLEQRVAELVRQRSEGEREVARTTEQRDGLIEVVRERQSRLEAARDGFPDVVARRDHLIGQAEALSTWDQRRTEAAESAVRLAEQRVAVAEAAAAAGFADVADALSAARTPDALAGIERRVREIEDARIAAQAVLDELADVSPETEVDVSGAEQRFHEATAGAEKAAENLAVATGKVERTERLATHLREVWTRLEPVAAEFEELDALTDAINGRGQNTRAMTLRTYVLAARLEEVAMAASTRLEHMSHGRYRFVHSVEPGKYGTRGGLGLDVLDDYSGRRRPAKTLSGGESFLASLALALGLSDVVSAGAVLDTLFIDEGFGTLDAETLDLVMTTLDDLRAGGRVVGLVSHVEELRQRIPTRLRVTKSRTGSTLNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA51</accession>
    <name>A0A7W7TA51_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ORF">F4559_006726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="235" mass="26699" checksum="787CCA5D310519F8" modified="2021-06-02" version="1">MTSSRQTPPFHRSVVSYVQRGERMTVGQERAWDRHWERLGREVKALPDGPVDFAAWFGREAPVLLEIGSGMGETTSRLVAAAPELNYVAVEVYKPGLAQLLMRAEALEATNLRVLRGDAVDLLTEHVEPGTLDGVRIFFPDPWPKKKHHKRRLVQPGFVRLLAGRLRVGGTLHLATDWEHYADQMLAVCSAEPLLRNLHDGWAPRPDWRPVTKFEQRAVEEDRVSHDLMFTRVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA69</accession>
    <name>A0A7W7TA69_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4207" checksum="CD8FFE6277E24A80" modified="2021-06-02" version="1">MPESSVREAAQRLGVNQARVRALSSTGKLAGRRIGSHTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA73</accession>
    <name>A0A7W7TA73_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046112">
        <property type="entry name" value="DUF6049"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19516">
        <property type="entry name" value="DUF6049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030970291" evidence="2">
        <location>
            <begin position="25"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="756" mass="79062" checksum="2E7D72EE7E4A19D7" modified="2021-06-02" version="1">MKRLLSALAVAGVLVVTGGPAAGAAPSEPGPLPIKPAPATQVWSTLDALTAQPGDQSQTWLRLDVEQLTPRVVTAGGPAEVTVSGKITNVGDRKISDIEFRLERGEPLKSEDEVRKALREPADAEFVQPEFTRIADELARDETREFSLTIPLRGTADTALRIDQPGIYPILANINGRPDFGGRARLAALSTLLPVVSVPGGQDAGPPATPAKITVLWPVADRPRLIRVGSDGQSLLTDDQLASSFAPGGRLYGLLKAYESAVTGPLAPAMCLAVDPDLLRTAIAMAGGYQVRGLGEGKGRTDADLWLRALRAAVAGRCVIALPDADADLVALTRAGLGDLTGLALGGGELVREALQVQPLPDLVWPEDGVVDEQTFTDLTTRGVRRLVLDQSAVGDAPGTNPVRLGEQGGGDAAAPTTAVRIDAMVSDALRGTAQTFGGDRPTPVSVQNALAALAYRTGFQGDGRNLVIAPPRRWSAPTGEITTFLDVTENLVASGFATPTGLATVLDGPAPEQIATLGYPVDAGVREVSPTITAAVGDSYREVVGMADAMRQVDAADTPVADLVDPLRLDLLRVVSGAWRGDESGARATLVSGMAEVDALRGQVTVTEPNSPILLGSGDSPIPVTIRNNLGVRVVVRIVLEDAPGIRAKEFPDQVLPAHGERFISVPVEVLRSGRFSLHLRLTTPGGVELGERARLEVSSSAYGTITLVITCLAAGLLVLLVSRRIYRRVRAVRAAAVLVPDDAEGVTPEKSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA86</accession>
    <name>A0A7W7TA86_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="21977" checksum="D158CD99DD98ECB2" modified="2021-06-02" version="1">MATPVYDGAARSPQRGRPRDASRDDALRQAALEVMADVGYRALTMDAVAARARAGKATIYRRWESKLDLVIDTCTQLAQRNLTEPDTGSLGGDLREFLSTFAGFLSGPIGKAAQALVGELPHEPELATAFRDTFLIAQRDVLRGILDRAAERGELKPDAPRGTVVELAGAALIYRLMLTGEALDGAFVDRMVDQVLLPLVGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA87</accession>
    <name>A0A7W7TA87_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum_form domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026004">
        <property type="entry name" value="Septum_form"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13845">
        <property type="entry name" value="Septum_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031406430" description="Septum_form domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Septum_form" evidence="2">
        <location>
            <begin position="50"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29100" checksum="41C2C143DA7B642B" modified="2021-06-02" version="1">MRNRVITVVVMVALTAAACTSHVPGTPDAEVVSPVLTPAADALPAPGQCTDSGVEVIACTEPHDAEVTEVGTLDLTAAEPTERDLRRAALPACRTALTRHLGSTDHDATRLQVRAFWPSAEGLARGDRWRLCAVTELAPDGTPKKRTSPTKDLLKAAGFATVQLCAEGSPAKEERPRFTACDGPHLAEAVPGVLELGKPTDPSPSRDFVDEKARQHCVTAVKGYVGADRGDVFASWRTYGSQGWSEGFTTAICYAEATRPFTGTLWGIGTKPLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBN7</accession>
    <name>A0A7W7TBN7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase (GGDEF)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="310"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="483" mass="52267" checksum="D13AED8C0E754EAB" modified="2021-06-02" version="1">MKNSLTDQKASGAVGRLRFRDWDVWSLRPAALAYFLIVEAVVGTAAVWLLTTLGSVDRADWMRFGAVMFALTVHLTIVRRAEEARRDESSGPHIDLTSVWTFAAAIALPGALVVLVTVWMRILVQPIARRQPHRFVFSSASILGGTMLAWAVVHLSGLSLLATGDVVTDLGLVLVLIVAAVLNWSVQGMNIAAALKIVTPHTRMVEFLGSRADNMLELSTLGAGAMLGMLMTTHWVGPLLLVFPVILVNSLLNKASERRAHLERLVREQERLQARLTEDAHTDFRTGLLNTAGLVEYAGRLTDRCARDGQPVTVLAVDLDHFKRINDTWGHPAGNAVLAEVGRILRGKLRPGDVAGRDGGEEFVVVLANTGLSEGVLIAERIRGAIGGMTVVTTDKHRNNVALRGRDLPYAEGPELRAISASIGVAVLPENGDSLASGQHSADTALYAAKENGRNQVRVAGLDIRPRRLPVPRVDEPEITRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WSZ0</accession>
    <name>A0A7W7WSZ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21157" checksum="196FC03B60C36CDF" modified="2021-06-02" version="1">MIEVRPGGRRRIDRVLAPDYAEGIDRLPLGEVRALRDEAAQEETDLSYLRRLLHARIDIVRAEMRRRTEGGAAVVDRLASILAGNAVGPASGLGRYQTREPSRADAHQRHVEALLADVDLSDVSALSDDKLALALRTFAGEESSVSTRRREVQAVVDHLNAEIASRYQSGSASVDELLAAERGWPVNPGRSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTB3</accession>
    <name>A0A7W7WTB3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">F4559_000273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19414" checksum="773BC54D84CEE09B" modified="2021-06-02" version="1">MPTPTKGRRLGGSPAHERLLLANLATSLFTHGRITTTEAKAKRLRPYAEKLITKAKIGDLHNRREILKVIRDKDIVHKLFAEIGPQFADRAGGYTRITKTLPRKGDNAPMAVIELVQEKTVTSEAERARKTKFAKDEAPKAAVVEENEVEATEAESTEAEAEAVEVKDEDKKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTE8</accession>
    <name>A0A7W7WTE8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="13739" checksum="EAB355C65282363E" modified="2021-06-02" version="1">MEFRIDRSSGLPAYLQLVRQVREALRLGWIGPGDRLPTVREVVASSGVNANTVLKAYRELELSGLVEARQGSGTFVKATLGSTDPAVLAELRGRFAAWVREARDAGLDNEDVDALVRSVLSDEGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTI2</accession>
    <name>A0A7W7WTI2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13017">
        <property type="entry name" value="PTHR13017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="26314" checksum="7CBB4787021264EF" modified="2021-06-02" version="1">MTTVDQAKQQARNRVWDLLERERAAPPGVHGRIPAFHGAEQAAERLAGLPQWRDAEVVKAVPDTAQQPVRAQALRDGKLLYMATSKLAHQYPFILLDPAALDPDDAADRHTATRIGRPVEVDTMRPVDLIVCGSVAVNRHGTRLGKGAGYSDIEVALLQEAGLIGRHTTIATTVHDLQVVDDDLPETHHDFSVDLIVTPTTVIACPDPRRPHGLHWDDLPPDKIAAIPALNARHNTDKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTK1</accession>
    <name>A0A7W7WTK1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17368" checksum="6921E4F83B5115F5" modified="2021-06-02" version="1">MSIHDIPVATLSGEPSSLGSLRGKALLVVNVASRCGLTPQYSGLERLQREYGERGFSVVGFPCNQFAGQEPGTAGQIAEFCSTTYGVSFPLFEKIEVNGPGRHPLYAELTTHADEEGTAGDVQWNFEKFLVSPDGEIVGRFRPRTDPEAPEVIKAIESALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTQ2</accession>
    <name>A0A7W7WTQ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkanesulfonate monooxygenase SsuD/methylene tetrahydromethanopterin reductase-like flavin-dependent oxidoreductase (Luciferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="39038" checksum="6E3C4B99D597B5BA" modified="2021-06-02" version="1">MGTGLHLAVALEGSGWHPAAPHDGDARFTAGYWADLVREAERGLLDFVTFEDEFGPVGRLDSVQVAARVAPLTRNIGLVPTAIVTHTEPFHLSKALATLDYVSKGRAGVRLRGSWKEVDYAHVGRRTFSEPVTREVDDDLLAETADYAEVLRRLWDSWEDDAEIRDAATGRFIDRDKLHYIDFEGKWFSVKGPSITPRPPQGNLPVAVLSHEQVAHDLAKAAADIVFVTPQDFDDAREIATQTEGVLRFADFVVHFDADRKARLDAVATEDSDAYIFTGDPGALADLLLEWRTLGYEGFRLRPGSLPDDLNVITKQLVPELQRRGVFRTAYEADTFRGLLGLPRPANRYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU5</accession>
    <name>A0A7W7WTU5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7211" checksum="ABA9EC5806422105" modified="2021-06-02" version="1">MNDTTTAAIAAMLMAFVLGLVGLLSTRRSTTARPRPRPRARRVNWGTVIVGLATIISTVLAAAAYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTW9</accession>
    <name>A0A7W7WTW9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoA</name>
        <name evidence="14" type="ORF">F4559_000272</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="13">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="244"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4962913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="350" mass="37704" checksum="8415846A0E3C4E26" modified="2021-06-02" version="1">MLISQRPSLSEDAVNETRSRFVIEPLEPGFGYTLGNSIRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTDIILNLKELVVSSEEDEPVTMYLRKQGPGAVTAGDIVPPAGVTVHNPDLHIATLNGKGKLEIELVVERGRGYVPAVQNKQAGAEIGRIPVDSIYSPVMKVTYKVEATRVEQRTDFDKLILDVETKPSITPRDAVASAGKTLVELFGLARELNVDAEGIEIGPSPAEADTIAAFAMPIEDLDLTVRSYNCLKREGIHTVGELVSRSEADLLDIRNFGAKSIDEVKMKLVGLGLALKDSPPGFDPSAAASDYPTEGWGVDTSVDTHDDGQDYAETEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU12</accession>
    <name>A0A7W7WU12_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9545" checksum="D1476120923853F7" modified="2021-06-02" version="1">MTTDRDSGGVQLWNILANMLHRRANLPADTLITDTIVISRTVRYDADGHPRYRVHLTHPHGPMDPHLEQGILEAALRQSHERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU46</accession>
    <name>A0A7W7WU46_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative blue pigment (Indigoidine) exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="140"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="289" mass="30262" checksum="BFE1D61C01133E74" modified="2021-06-02" version="1">MLSNLLTAFAPMVWGTTYYVTTEFLPADRPLLAGLLRALPAGLLLVAITRRLPRGDWWWRSAVLGALNIGAFFPLLFLAAYRLPGGVAATVTSIQPLLVAGLSTALLGQRLSLRVALAGVAGMAGVALLVLRAEARLDLLGVLAALGGAGVMACGVVLSKRWVAPAPPLVTTGWQLIAGGLMLLPVTLVVEGLPATLTWTNVGGYAYLTIIGAAVAYSLWFRGVAVLPVTTVSFLGQLSPVVAVVTGWALLDQRLTGWQLLGAAVVITVILLMQSRPATRPALVDTKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM2</accession>
    <name>A0A7W7WUM2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20878" checksum="D951A8AD570314BB" modified="2021-06-02" version="1">MGKLTYGMNVSLDGYIADANGDLGWSEPDEELHQYWNDRTGDVALSLYGRKLYELMSAHWPTAAQVPDVPPVEAEYARLWLAMPKVVFSRTLESVDWNSSLERGDAVETTQRLKAETDGLMEVAGATLAAPLIRAGLVDEFHVLLTPVAIGSGTPFFPALHRWLKLDLVENRTFKSGAVLLRYRTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUZ2</accession>
    <name>A0A7W7WUZ2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">F4559_001726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14521" checksum="0B407BE3516602F2" modified="2021-06-02" version="1">MARVKRAVNAQKKRRTTLELASGYRGQRSRLYRKAKEQVLHSLNYAYRDRRARKGDFRKLWIQRINAGVRANGLTYNRFIQGLRLAEIEVDRKILAELAVSDPGAFAALVQLAKAALPSDVNAPAGDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV07</accession>
    <name>A0A7W7WV07_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="3">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="26980" checksum="D919B066AC4840B1" modified="2021-06-02" version="1">MSDQEPEGIRLQKVLAKAGIASRRVAEELIELGRVQVDGEVVREQGRRIDPETAVVHVDGVRVVLKDDVITLVLNKPRGVLSTMHDETHRPCVGDYLKHRKERLFHVGRLDADTEGLLLLTNDGDLAHRLMHPSFGVSKTYLAEVPGPVPKGIGKELRAGVELEDGPASVDSFKVVSSMPGRALVKVVVHEGRKHIVRRLLDHVGLPVQSLVRTAVGEVLLGQQRPGSMRVLNRQEVGSLYKAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVF1</accession>
    <name>A0A7W7WVF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15179" checksum="AE52081D6EF35B35" modified="2021-06-02" version="1">MSRGRRIAAAWSSLSARELTDQIRQAVKSRDADVREAWEVVRADQVLAARVRGALAGLRAEFRGHRDEAMWLLWISQAQQRLNRPVEPAAPEPEPEVADVVEEVVEVRPPDRPEPAPRADRPSVPTMVFQEPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVW1</accession>
    <name>A0A7W7WVW1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14847" checksum="AE411A494CD190DB" modified="2021-06-02" version="1">MVAFVVHDGRVAVFTQDDEDSGLQVPAGTLRDGERPEEGALREAVEETGLAGLRLVGFLGRYRWDISPIREEVQDRHVFQFAVDVPPPARWDSAELHDGQRAPTPLHFRWLPLDDPGLAELVVGQGTLLDRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH7</accession>
    <name>A0A7W7WWH7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="29912" checksum="FEEF41A6B1C0EFAC" modified="2021-06-02" version="1">MAQEDLAVDLLWGDGGGPGLNVGRIVRAAVEVADESGLDGLSMRKVAERLGYTAMSLYRHVPGRDHLVDLMRDAVLAESAGPLPEGDWRAGLTACARRMWEVHRRHPWLAQVRGPRRLPGPNGIVAYERMLAVLAGTALAPAEVVAAAGLVGRFVEAEALVLLETVEAERASGVDHERWWGARHSLYAHLDRYPTLSALWRDGGFDDPLDTFGFGLARVLDGIELLIKQRDEKRDETCRTCGGPVEQPASGRPRAYCSRACQQRAYRRRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWW3</accession>
    <name>A0A7W7WWW3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">pPIWI_RE_REase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040828">
        <property type="entry name" value="pPIWI_RE_REase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18154">
        <property type="entry name" value="pPIWI_RE_REase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="pPIWI_RE_REase" evidence="1">
        <location>
            <begin position="299"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="414" mass="44911" checksum="A936A92B969F1968" modified="2021-06-02" version="1">MIETGVGNDTRDDAAVRHKVMKAAAIAAHALTDTEQEPVARLRSLWDAHGAVLAARGVGVTLPFDEFRRMLSGDLAELLPDGVAPAEMAGWRLITADGEFDDDVWDLEQEQRAVLRALASTTRRGKSTSSEILQGELDQDTVYTALRKRQNQGAYERGRRALIDTPAGSDAEVRELNLPSTVTDHYRAIPTPSSFGQWWFACPLCKWPMRITVRGAGKAATGTARCHHRPHVEFGASYNFRIPDTGKPPVLVPAPPPTAPTGVERVLFPDVTGRVPEALPVAGHKALTRGVWRSTTIPGLVEVALYDALTARGLACKLWPDLDSYDLLVKVPVSNGTDTSYRIDVKDFTSALLLADKIRADEGDAGGAQWLVVPDYRRATVSMLSAVCGQFGLRVAHASDLGARICEEAGTSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWZ8</accession>
    <name>A0A7W7WWZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="26939" checksum="23FC3A5EE4AB422A" modified="2021-06-02" version="1">MIQTAAAVADRDLAHLPEPARRHLRFAGVVGRPIDTFFEMRAHGWFRRRPTDRWTSCHLRQRNTAPEISRDFHLHLTAGHLLPIHAVDGYDHGHGRMHATTLGVFTVADARGAEMDQAELVTYLDDAILFAPSTLLRLPVAWTAVDDHAYEVTLTDHDTTVTARVTVDDRGAPREVSTDDRWADLPTGLTKVPWSTPVDGWVLVADRMRPRRACAVWHLPEGRFTYAQFEFTGAEITYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX30</accession>
    <name>A0A7W7WX30_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyisobutyrate dehydrogenase-like beta-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="29938" checksum="0CEC3B3384C6622B" modified="2021-06-02" version="1">MTLTVLGLGAMGTALTRAWLAAGHHVTVWNRTPARAERLAAEGATVAATPAEAVAANRLVVTCLLDHASVVDVLDGTDLAGRDLVDLTTGTPAQARDRAEWAAGRGARYVDGGIMAVPPMIGVPDSGAYVFYSGSVDLFAEHERTLAVPAGAKWVGDDPGHAALHDVALLGGMTGLFAGVTHAFALVHGEKDIDTGEFATLLVDWLAACLPFTQRMAQRIVTGDYTSDVTSNLAMQVTANRTMVDTAVDQGVRPDLITPYLDLSARGVAEGQGAEDGARLIELLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA7</accession>
    <name>A0A7W7WXA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030660574" evidence="2">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11000" checksum="E7EFB5477DF6C743" modified="2021-06-02" version="1">MRVLRLLIAAVVEFSVLFGAPVVADPHPHRETTEHQLLIQALTCALDRCETGPADLGPEPKALVTPPPIDHGTDAGDHPVLPAALVDPTAARGPPPTGFHPESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXB8</accession>
    <name>A0A7W7WXB8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="2">1.6.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="170" mass="17640" checksum="5146191AA5502B5D" modified="2021-06-02" version="1">MARALVVFESMFGNTKAVAEAVRAGLAEGGQVDVVEVGEAPDVLPGDVDLLVVGAPTHAFDLSRAATRKSAADQATGELVSRGRGVREWLDALAPAGRAVSALAFDTRVKSGWLPGSAAKTITKRLRRLRFAVAGAPTSFHVGGTPGPLLAGEVDRATTWARAIRPASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC9</accession>
    <name>A0A7W7WXC9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16383" checksum="ADEC18BFF7B94038" modified="2021-06-02" version="1">MQEFDQGDGQAVQSCGIAGLADHHGARPPCGEVNKIRPVSGARARLNGERRAAHGLPRIDADTLAATVNRAGNAVDEGAVRDVLAVFGSDDRLWTEDLLSRLAEHDGRYAGWTGEALAGVLAPLGVRPVQVKINGRNRNGYRREFFTIRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD1</accession>
    <name>A0A7W7WXD1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein OmpA-like peptidoglycan-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="249"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="373" mass="39012" checksum="1842088B0FF88C92" modified="2021-06-02" version="1">MRAVTGPVVAVTLGLSAVACGGTEERPTGGSVAYVLGVHANAPAAASTSVLDDAVSGQAKLTVVLADGEPKILVARDLTAKAANDDAKRKEREDRKKELRGTLSQARPAKPEVDLLAAIDLGARSLDREPRRMVVESSGLSTTGSLSFLAPGMVLAEPEEIADDLQRKKLLPALGGVTVRLRGIGDTEPPQPRPGIHERSNLVAIWREVLTRAGATVEVDDQPRTGKAPDDAPAVSLVPLTPVTVAAPKAEETVPLPASAFFVADKAELLDRAAAVDALRPFAEHVKQAGGRIDLVGTTARVGDKEGQVALSGQRAEALRVVLVDDLGVPADRVTSSGVGSYHADYVADHDAEGNLLPDKAALNRTVRITIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG7</accession>
    <name>A0A7W7WXG7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="SSF140376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14841" checksum="BBB2A28D0867A5CA" modified="2021-06-02" version="1">MPGRQELPSTVARSSKKAQRTWIKAHDSAVESYGEGERSHRTAFSALKHSFEKVGDHWEAKDHKGSSEKQAARHAPRTGRTHGGVDANATKQHLYDVAKRLAVPGRSTMTKKELVEAIDKANRRETAQRAGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH7</accession>
    <name>A0A7W7WXH7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NBD/HSP70 family sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="38655" checksum="D3D5F4423757E5D8" modified="2021-06-02" version="1">MLDNGPVARSTIARLTGLSAAAVTRQYAELADLGLLREVAEPRVPRATVGRPHVPVDIDIDRFVCYGLHIAYTHVTLALVDLRGRVLRQECVPHEGTSPEAVLGGVLRRFPLFRERCADGRTPLGFGVATGGRVDPERGVVVRHSQLDWRDVPVRDALRPLGLPVHVENHTRALARAERLFGDHGDRSSLVHLFVGNVVDASIVTGGSVHQGPGSAAGELAHLRLDGSTAECPCGRRGCLQATVSDRAVAERAVRAGLIPEPSLPTLIDLAIAGDPRAVDLLLDRARHVGRAAGLLLDLINPEVLVLTEAGSIVLPDECLAEVRRQVGDRAGSVVATSFGPDVLAVAGGSVVLDAVYGSPHELCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ2</accession>
    <name>A0A7W7WXJ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14711" checksum="7FC8E9E500CB025F" modified="2021-06-02" version="1">MAIAGGHRFPITFDELFPEGFFVLSVERASEYVEGKSPRPAVDKVTGLPVWLAQGTDPSAKGRNTGQVVKIASEYQPVPPETLAGTPFRPAVFEGLKVTPYVRDGWIAYTVWADRMLSPNTATRGSRKADNGTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ6</accession>
    <name>A0A7W7WXQ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quercetin dioxygenase-like cupin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="24277" checksum="91C3EAE78D886D84" modified="2021-06-02" version="1">MNSGVFHLGEPGELDPRQVLTGPLRALRRVRLAAGESAVLDAPDAEFSLFVLSGDGTVTTGDAQVPLREGVSVTAPLHTRPRITAGAGLDYFLVELAVPDPAPVPGAGPVADEGATVEADRKSGPVSGRAVDEAAGSPTGPDSGRVRGREAGSVSDPEADTAFGHPSGSAGRVAGTHAARAAGGVVEPVSGRPAVRGSGGAPGLSADPDSGQVRGEGAGPVRGDGVGSVSGRVVGWAADRGAGPGGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXS5</accession>
    <name>A0A7W7WXS5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="14666" checksum="6CC2CD54C261C4ED" modified="2021-06-02" version="1">MSGGTLVLDSEGLVKIAAGDSRARAYLETARTRGARVVVSAVTLAEVLRGGHRDTAVHRVLSRIVVTPVTPELGRAAGELLGSTGLSGHRCAIDAMVAATALRQGRPVVLLTSDPDDWERLVEEPERAKEQRVVVVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXS9</accession>
    <name>A0A7W7WXS9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recA</name>
        <name evidence="12" type="ORF">F4559_005044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4967685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="37054" checksum="AF182E89C90105B0" modified="2021-06-02" version="1">MAPQAPDRDKALELALAQIDKQFGKGSVMRLGEEGRAPIEVIPTGAIALDVALGIGGLPRGRVVEIYGPESSGKTTVALHAVANAQRNGGIAAFIDAEHALDPEYARKLGVDTDALLVSQPDTGEQALEIADMLVRSGALDILVIDSVAALVPRAEIEGEMGDNHVGLQARLMSQALRKITGALNSSGTTAIFINQLREKIGVMFGSPETTTGGKALKFYASVRLDVRRIETLKDGGEPVGNRTRVKVVKNKVAPPFKQAEFDILYGQGISREGSLIDMGVDQGILRKSGAWYTYEGDQLGQGKENARKFLRENPDVGNEIEKRIKEKLGIGATLESEETAAAPVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXV7</accession>
    <name>A0A7W7WXV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chlorite dismutase</fullName>
            <ecNumber evidence="4">1.13.11.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.49" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050587">
        <property type="term" value="F:chlorite O2-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="PTHR36843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="26504" checksum="8E06B02B09AC0B5B" modified="2021-06-02" version="1">MARLNYTELNDTIRYTMWSVFRVDAGRLPDERGPAAAEAQEYLDGLEGKGVVVRGVYDVAGLRADADYMIWWHAEEIEQVQQAYTGFRRTAVGRVSTPVWSQVALHRPAEFNRSHVPAFLAGEEPRKYVCVYPFVRSYEWYLLPEDERRKMLADHGKEARDYPDVRANTVASFALGDYEWLLAFEADELHRIVDLMRHLRGTEARLHVREEIPFYTGTRVPAAELVANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW4</accession>
    <name>A0A7W7WXW4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11631" checksum="4259992E3B450DA6" modified="2021-06-02" version="1">MNEVPAVDQETAEVYASWFRALSDPSRIRILNLLARQEAPMSVGEVVDAVDIGQSTVSHHLKILREVGFVVGTREGTSTRYEVNRACVTKFPTAADVVMGVRPDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY27</accession>
    <name>A0A7W7WY27_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24702" checksum="5D522D600CF58567" modified="2021-06-02" version="1">MSRKIQYRTRRPIAVADRPQGTPLSPAQRLFVDRCRELPQLADPLDVELTVGAAVADLDVDEEFWAGVVAHVASWPSRRNVALLRALAVLLTGRPRDWAVEAAGPVGSTLRVTGAWTCDRSLDAGYLVLLCRYAFSAREHAMVFLIDEVEGGLVRGAFVTRQVEVARERLARQAPLDAIGAEAAHWLLAKSYDRLDRRPDLRVGDDVRSTRLPAKRRIALAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY42</accession>
    <name>A0A7W7WY42_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="398" mass="44254" checksum="0476DC25022C5EB8" modified="2021-06-02" version="1">MTETIHRELPVARGVFDPDPLLGALRETEPVSRVAFPDGHLGWLITSYELNREVLADNRFSNRAELQRMPIRIGGEVVGQQPAAKPGMFINMDPPDHTKYRKQLTGQFTVRRMNLLMPRIDEIVADHLRGLRAHGSPVDLVKHFALPVPSLVICELLGVPYEERHGFQESTRRMVNLESSFEDIMAAFTEVEEYLAGLVARKHDDPGDDMLTGLIQGGQLTDEEVANIGVLLLVAGHETTANMLALGTLTLLRHPEQLAALKADPSLVDNAVEELMRYLTIIQFGTQRVALEDVELHGHTIRAGDAVIVSVPAANRDPRRFERPDEFDIRRPASGHLSFGHGVHQCLGQQLARIEMRAGFAALFREFPDLELAVAPEEVPMKTGMSIYGVHSLPVKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY6</accession>
    <name>A0A7W7WYY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="940" mass="99235" checksum="1F612AB2404BF30E" modified="2021-06-02" version="1">MNRDPFGTEALRDSVLAAWRGSPTRFREDANAEEDLRLGGYRDRLLVELAQNAADAAGDRPGVLRLSVVDGELRAANTGAPLTAAGVEALASLRASAKSGDTVGRFGVGFAAVLAVTDAPRVVSSSGGVLFSASRTRAAVPELASARGGDVPVLRLVWPTDEADLPAGFDTEVRLPLGLDAAGLLDEFAGQAPDLLLALPGLRRIEVDDRVWERTTVDGVVVLAGPEGERRWLVHRVGGELPADLVQGVEARPHWSACWAYPLDAPLAGDVLHAPTPTDEKLSLPARLIATLPVEPSRRRVLVGPAASYVLDQACTAYPDLVTGLPAIDRMDLVPLPGFPLSEVDGLLRAGVLAALRRATWLPMATGDWASPVGATVLDAASEALVDLLEDVVPGLLDGELTLPKYAKALAALEVPRLSVAGVVTALTGVGGDPTWWHDVYAALAPLADVDSAAREALGSLPVPLADGRLVGSPREVYLLDTPFEVPGLRIAHPDAAHPLLLRLGAVEAGPAELLDSPAVREAVEHSLDDPALEGRDLLDAVLRLVSRAGGRPWLGALALPDAAGEWRRADELVLPDSPLLEVLEDDAPVGVLSADVAAAWDRPTLTGVGVLDGFTVVVDDAPTEPDHDLADEGYWWDAAEEPPARVLGIRDLDLVADDKWPAALAMMAGSPETWRAVVEPDGYTGWWLARYAQFAGTPPREWRTADAESLTGLYDVVPEVGLPPHVLAACGVRTELAVLDEDDVTDLLARLGDPARTLSDALVLRVHAALAEVADAVSVEPPDRVRVLTGAAEPADEVVVMDRPWLLGVLPPEAVLTADTDPEALAELLALPLASEEVTGTVLTTGEEVGWAELAAVRLACDLLGVALPAGTVTVHDRLEVSAEGDTHDVLWWLDEDVLHTADTPEGLARALAWATSRWPDRHTFAALITDPTPTILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA2</accession>
    <name>A0A7W7WZA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6512" checksum="1B4BF248CE615059" modified="2021-06-02" version="1">MGELFSLVDLLGEPAIQLSIDDALAEVAEQNTAAATVENDVMPSTWELIPRETITGQGVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZE6</accession>
    <name>A0A7W7WZE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EmrB/QacA subfamily drug resistance transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="546" mass="58043" checksum="4F53FDC5FF68BCE5" modified="2021-06-02" version="1">MSETTAAPTGAALLTHRQILTILSGLLLGLFLAALDQMIVATAMKTIADQLNGQTLQAWATTAYLITGTISTPLYGKLSDIYGRKPMYLTAITLFLAGSLLSGIAGSMYELAAFRAVQGLGAGGLMSLAMAILADITSPRERSKYTGYFMAVFGISSVAGPVVGGLFAGMDTFLGTDGWRWVFLINVPIAAVALFVVARVLNIPHKRVNHRIDYVGALLLTVGLVPLLIVAEQGREWGWDSGRSIAMYVVGVLGLVGFVFTERRMGDEALLPLRLFRKSTFSLGNTLNFLLGVGMFGGMASLPLYLQIVKGFSATEAGLMMLPLTLGIMTAAGTSGNITSKTGRYRVFPIIGFGLLSVAMFVLSTIGTDSPSWQPLTLMFFVGAGLGLCMQTLLVAIQNDSEPRDMGVATASATFFRQIGGTVGTAVFLSILFSTVVDKIGDGLRNALATPAYQQALAGNPEFAAMLKNQQLDLNNTEFLSKIDPVLARPFLDGFSDSIGLVFLVGGMVTTIGFLVVWFLKEIPLSNRSGLERAKDAAEPAPVAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXC9</accession>
    <name>A0A7W7SXC9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="120" mass="12942" checksum="B60B60D4217976EC" modified="2021-06-02" version="1">MTAKKHLRPDDARELALLSGVDGSADLSEVSLLVAWAKVARLVRAFKGRLVPVKSAVGLVDQMDGLRERMWERDLPAVLAAPEALGAVEPADPTHVRATPPGLWGARRMLRAEGFDVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXP4</accession>
    <name>A0A7W7SXP4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20476" checksum="3BAA79D39CBB45FF" modified="2021-06-02" version="1">MISIRLEAAYLRPEKALFRRDPREPDDVFANGFPAHGPIPPVDEDFPGVEGDDDFVLFHTAIEVALLGTPAPGCPQVAQDSKSRTVVEHLYEGHHRHGLHVDITRHRNGLRSLPPERRGLLLFDEGFPAAHVLRAFPMLITLRLDEYGRYRVHGTRFLPPVENPGFEFRAEMDALNEGTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXT2</accession>
    <name>A0A7W7SXT2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">F4559_000238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_030473471.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="13793" checksum="4B73F11E4A115502" modified="2021-06-02" version="1">MPTIQQLVRKGRQDKVAKQKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSGIEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY51</accession>
    <name>A0A7W7SY51_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="30903" checksum="9AF752472BFD5266" modified="2021-06-02" version="1">MTSKGASFRQRRVSTELRALRRARGLSCAEVAKAIGCSESKISRMETGQRGLQVDEVAAILGYLQAPAALRHELVALVRDGEGRNWHAVHGKLPGHWKDLITIEAEASALYNFEPMVMPGLTQTPDYARAIIAGGTYNLTVGELDNLVATRMGRQFVLGRAHVHLIIDEIALRRPLGDRQMMHAQLRHLMALTSRPNMEILIVPFDSIAHPGLSGAFVRLEFNDQPGLVYVEGRGTSAFLEEEVHLEHARLAWHKLRDLALSPEQSVGLIAKIAGEMSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY71</accession>
    <name>A0A7W7SY71_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="38098" checksum="C20F4DA855A8AC03" modified="2021-06-02" version="1">MSTSARLLLPAGNQLSRLLHASPVLMDTTFDQLRTLITVYETRSALRAARALGREQSSVQKQLDTLNRNFKQLCGEPLVVKQGRGKDVLITPTGEALVELARTTLGSWLDSIHECRRKLGTTLTVGTTRFMLDSLAKAWHHVAEDFRRRDVELKVVHIRTKDIWSSLESKEVDIVCGSVVTPADGAGAGFDEFDVIEWRRGGLALLTNLPEHRLGASVGTGDLPGLPLVVPGDGLIAEFLRGWFGPDYRNELDIAAEIDEIQYGMSLLRSGLVSGCMIVTSGLGVVAANNELREGSGLRVVELTNDRKPRLERLVGVFARTDERAKFPADHPLNLLWAAFQREVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYD5</accession>
    <name>A0A7W7SYD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031301397" evidence="2">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="19851" checksum="D20A67229591A6EC" modified="2021-06-02" version="1">MKRKVFVVLAFLGVVLAPVGGLFGKADHAGWVGAVGMAVGGIAFPFAVTLVSRRLWPLFAGLLAGLFAVLAGMFFAPSLWLKVDAETLTGCEVVDERTVTSTKSPSTTVSTVDCAGERFEIVPFTSSSEFVGKVGSETTLLVDRTGLLKPVRPSDVESAAVWVVPLAVLLQLALVVVVLRLPPPKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC3</accession>
    <name>A0A7W7SZC3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="81" mass="8849" checksum="95826C8AE7F9B832" modified="2021-06-02" version="1">MANDDTWIYPAPAWRTGDRVAIDDSSRLDYDEAGTVIGPDPYDNGAWLVELDDGTETSAYSDELTGLIEPHSASSPERTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZH2</accession>
    <name>A0A7W7SZH2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24620" checksum="82F4C4697739A33C" modified="2021-06-02" version="1">MATHDDRTTGYSDEGPYPASGGVHHFDDGTTAFDKKTNAFDTSAYTPVDQFPTAAAHLDEEDTRRPFGWTAGPDIGLLVLRLALGGAFVLHGLQKVFGLFGGPGVDKFAQALQDMGFREAKVLAWVTGVTELAGGGLLVLGLFTPLAAAGLLGVMANVLVLRWRSGFFAPGGVELEAAYAAMAFGLLFAGPGRVALDRGRTWFRRPLLWGFLCLVLAAGATAATLYVFRNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU4</accession>
    <name>A0A7W7SZU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4/cobalt-precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
            <ecNumber evidence="8">2.1.1.271</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EC" id="2.1.1.271" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="331" mass="35187" checksum="6431541C44AC46FE" modified="2021-06-02" version="1">MTGRVSFVGAGPGAADLITLRGAKRIAEADVVLWSPAVVEVECVRDHARPDARLVDFSRVNAEEVADVYRHASAAKLAVVRLHAGDPTLWGGVREQHELCRKLGLDVEIVPGVSPVSAVGASIGRELTASDVASSLVLTGPETAEHVEEFAAHGSTLVVQASGSRTGQLVEKLLAGGYSDETPVVVAYKVSLPDETIAHTTVGGLEACVKEHKLYRTTLFLIGDVLKPNAARAPRDGVVARPRKWARRASASDAAWSAVHDWQEAARARRAAPKPVVEEEPQPMLELVTDLADEPEAKPVVAAAKRKSAAVRADSTARKPARAKKTTKRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T075</accession>
    <name>A0A7W7T075_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="8">
        <location>
            <begin position="278"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="401" mass="41675" checksum="B975CCE1040BBDD5" modified="2021-06-02" version="1">MSGALIFDAVRTPRGRGKRGSLHGVKPITLAAGVLDALARRTGLDTAAVDDVVFGVVSPVGEQGGDIARGAVLAAGWDPVVAGVQLNRFCASGLEAVNLAAAKVASGFEDLVVAGGVESMSRVPMGSDGGAWTTDPETMLATSFVPQGVSADLIATLEGITREDVDAYALRSQRLAAHAREHGYFARSLVPVVDRNGVTVLDHDEAIRPETTAEGLAGLKPAFRFHGDLGFDAVAIDRYPTVERIEHVHTPGNSSQIVDGAAAVLIGDDRAGRALGLTPRARIVSTAVVGTDPTIMLTGPAPAARKALERAGLGVDDIDLFEVNEAFAAVVLRFQRDLDVPDDKINVNGGAIALGHPLGATGCMILGTLLDELERRDLHRGLVTLCVGGGMGIATIVERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0I0</accession>
    <name>A0A7W7T0I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29857" checksum="1EC7C4982FB2FC37" modified="2021-06-02" version="1">MDDVADEIVEHYRSIDESTRITEGFGRLELERTREIVRRHLPPGGLRVLDVGGATGAHAAWLAADGHRVALFDVVAEHVARARRLAEDTPGLTADLGDARDLPVPDDSFDAALVFGPLYHLTEHEDRLAALREVRRAVRPGGWIFVAAVSRFASLFDGLARGFLFDPEFRRIVAADLATGRHRNDGHHPGWFTTAYFHRPEELRQECVAAGLEVVEVVGVEGLAVWLSHLADRWSDPADREVVPRSARLVESEPALLGLSAHLVAVTRTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0L8</accession>
    <name>A0A7W7T0L8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA-binding protein (MmcQ/YjbR family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12436" checksum="2079B94601C0C924" modified="2021-06-02" version="1">MRLDEVIGHCLGKPGAEETYPWGESELVVKVGGKAFAFIALEAATVGVKCGVDAEAASPWRERFPDAITVSAYIGRYGWNRIDLDKGVPEDEVLELLDLSYDSVVAKLPKSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T128</accession>
    <name>A0A7W7T128_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="59" mass="5857" checksum="C8124EF314FAC152" modified="2021-06-02" version="1">MLAIVAAVLFGLALLLDLAGASLGVVTGGLLVTAGLLCVALHLAGVGAGARTLSFRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T163</accession>
    <name>A0A7W7T163_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="5">
        <location>
            <begin position="295"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="4">
        <location>
            <begin position="479"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="670" mass="70656" checksum="647ADC9968CBAB22" modified="2021-06-02" version="1">MTWLAVALAAGGAVFFALAARLQHAAVHASEGSLKVLDLLRRPRWLLGLVLLVVGSVVHAVALGMAPLSVVQPVGVLAIGVTAVLDGRRRDLPVVVLTTFGVGAFVFLAAGSATATTVAPEAELHAGLVALGLVAVPGLLGVLSTRPTPRALGFGAAGGVAYGYVSVLMRSVSQDVQQGTAGLTTAISATGIVVALLVGGWFIQHAYAAGPPHLAVACLTVVDPLVAVGLGAALLGEAARTGGFTALAETVCAAVAVGGVVVLARNSSSSHETENPVTTDALRIVIAAETFPPDVNGAARFAHRLATGLAGRDHDVHVICLSEDGRARTEQVDGLTVHRLRSHRTPFHRTFRIGVPWEVSGEVRSLLKRLRPNLVHVQAHFVVGRYVLKHARELGIPSVATNHFMPENLFGHAKVPAWFQGAASRWAWRDLGRVFGRANVVTAPTPRAVELLHDNGFPRRAVPVSCGIDIDRYRSRPSVRTNEEPTVLFVGRLDEEKRVDELVRAVALVPTLKADIVGDGSCRAEWEMLARDLGIADRVRFRGFVSEEELLDAYAGCDVFCMPGIAELQSLATMEAMAAGKPVVVADAMALPHLCNQGRNGWLFTPGDVSGLADRLHAVTVDRAVTARMGAASLDLIATHAIDSTLEKFEALYARAMGLPTPTREIALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A0</accession>
    <name>A0A7W7T1A0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Subtilisin-like proprotein convertase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030652759" evidence="5">
        <location>
            <begin position="31"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="6">
        <location>
            <begin position="750"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="915" mass="93263" checksum="765B5EAF5233F355" modified="2021-06-02" version="1">MRTPLRGHPLVVLVAVVALGAVVPVPSATAAPAGGLPARAAAQIAALQEIKRSITGTDTKVDSALIVEQRRRKGSAAFGRLPSYRTGVEVRPDGTVSVDVRAVAVTPGLVASLGDRVRSVSVDGATIRAEVPLSAVGAIAARPDVRRVQVADAAPVDARSKEEQAGKVEADTLAAVDRTTANRATADPTTADPTTAESDRAHGADTARATHKVTGTGVKICVLANGITDLAAAQAAGELPEVEVLPGEEGGGYDGVPLLEIVHDIAPGASLGFATAGLGDARFADNIRALRSRLRCDILVDNGRAQDEPQFQDGVVARAVDAVAADGALYFAAAGDEGNVTDGTSGHWEGDFVDSGVGVGKFAGTAHDFDPSPTAKQVLDPLAVGSGGAPVTLSWADPLGAAGDDYDLYLVNAQGNVVGASQNVQDGAQDPVERLHVPDSQVDRLRLAVVKFRGEHRYLGLTVHGGRFANSFDGLKGYTTAGAIRGHAAAKGAIAVGAAPVGDPYPGDPAHPRGPYPGVFDVGQRPERFTSDGPRRVFFAADGTPRTEVRPKPDVTAGDGVKVGGSVRYGTSVSAPAAAAIAGLVLSGNPGLPAAQVREALATTALDLVEPGVDGRTGAGVLRADLALDFTGASPQPLVKARRPTPVNEVDGTPYFKPGTTAAVTVPVHNSGDGLAASTNVVLTSPTPGVTIAPRARSYGTIEQGRTGSGEFKVTVAAGVPLGTEVKLDVRVAYSGATSPTTASFGYVVGEPSAETRDFSYTGPAIAIPDDNATGVTATFPVSGLGRASKITFSVDGEQCTATEGATTVGVDHTFVGDLTGTLTSPSGRTATLFQRSGGTGANLCQVVFADDAARPFSSVTSVNAPFTGTWRPVGRLSTLLDDPVDGVWTFKLVDGLPGDRGSLRAVSLHLNGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1J7</accession>
    <name>A0A7W7T1J7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar lactone lactonase YvrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031227995" evidence="1">
        <location>
            <begin position="27"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="32426" checksum="D202AB2C9D14D622" modified="2021-06-02" version="1">MARTNAVLAVVATAISLVVVVVPAAAAPIPPVPSRSYDLPAGFRPEGIAIGTAPVAYLGSLADGDLYRLDLLSGRGQVFSQGPGTSSVGLKIDRRQRLFVAGGQTGEGRVVDAKTGEPLKTYRLWDQPGAFVNDVVVTDAAVFFTDSFNARLYKIALGPHGRLPDASTTVPLSGDFHNTPGAFNANGIAETPDGKALLVVQSSTGQLHNVDANGVSRVVDLGGERVPGGDGLLLRGRTLYVVRGSANEVVEIRLDRAGTSGKIVKRHANPKFDVPTTVAAFGDTLYLPNARFGTTPTPETTYTVESVHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1N8</accession>
    <name>A0A7W7T1N8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="3" type="ORF">F4559_002005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="11131" checksum="EF1BA429808C8896" modified="2021-06-02" version="1">MGESERGESAPRRRVSYWCANGHESRPSFAVEAEIPENWDCPRCGLPAGRDEQAPPAPPRNEPYKTHLAYVKERRSDADGEAILEEALTKLRKQREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S6</accession>
    <name>A0A7W7T1S6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18219" checksum="4C71EA71AB499EA1" modified="2021-06-02" version="1">MTAGTTAALVFVALYTAHHLADHWVQTDHQAIHKGLPGWRGRLACARHVATYTLTTLAAVLAVLWLPLGLHATWTGIAVGQAVSAVTHYVIDRRTPLARLAHATGKGDYHDRGTPRPHRVFAYRPDVEDDPTADLPLDQAPVVRGAYFLDQSLHIAVLFAAALITALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T217</accession>
    <name>A0A7W7T217_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="900"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1014" mass="107585" checksum="26086CA7F65CF210" modified="2021-06-02" version="1">MSVPEVFRFPASSGQRRLWLLDQLLPGSPVYNIGWRVAVDGPLDVDRLRSALADVVDRHEALRTTLVAPDGVPEQVVASTVPVELPVVDVAATEVAARVRDQVRVAFDLETGPLFRAVLLRLTADRHVLVLVLHHAIADGWSCAVLFDELARRYAGEDLPEPPIGYPDYALWQQEQSFDDGYWRERLRDVPTVLALPTDRPRPERPTGRGAELRARIRVGDGSFARLLALFGCVLHRVTGQADLLVATPVAARTRPETEGLVGFVANTVPLRATFDEDTTVRDAVTAAERETVAAVAHQDLPFERIVELADVPRSLAHSPLVQVLFAVEPVPGVRTAGDVRFGPEPVHNGGAKFDLSLTVERAGEDWFARWQYDAELFDRASVVALHDAFTAVLDADADTPVAELPLVRSTSDTAAGLVLDAVAAHPDAVALAGELTCGELDRAANRLAHALLAAGARPDEPVALCLDRGAATLVGVLAAWKAGAGYLPLDPSWPVHRLTSMATDAGTPVLVTDGSVAVGGPWTTVDSRAVHEFPDTPPQAVPQHPGMLAYVLYTSGSTGTPKGVRVTQGGLGALLSAMDDVLDLGSDDLLASITTPAFDVSTVEMFVPLLRGVPLTVLDADEVADGALLRARIDESGATVVQGGPASWRMVVAAGGVPDRVRLRISGGEAMTRDLADELQSGGATVIDGYGPTETTVYSAVGVVARAPHPVRLGPAIAGTTLHVLDRALRPVPPGVIGELHIGGAGVARGYHGRPDLTAAKFVPDPFGTGGRLYATGDLVRRRVDGGLEFLGRADRQLKIRGYRIEPGEVEAVLRAHPDVADAVVVAWSANASDVRLVAYVVPAAPADVREHLAAHLPEYMLPASVVDLESVPRTGTGKVDRSALPEPTWHTASADRVEPRDETEASMAVIWRAVLSIPEDVPLGVHDNFFALGGHSLTATQMLARVRTTLSAQVPLAALFAAPTIAGLSVAVRGADDHLARGPVPLLDQLDDLSDAEIDRLLGTLSDGEDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T229</accession>
    <name>A0A7W7T229_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="847"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4965124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="923" mass="96807" checksum="7FEA581B5C08D821" modified="2021-06-02" version="1">MSDTRIAVVGMAGRFPGASDVDGFWRLLADGVDPLTRDRGPAHGLVADGDLFDAAFFGYAPGEALLIDPQQRVFLQCAWEALEHAGCDPATYPGVVGVYAGSGDTGYAELLRQHRHRFPEVSELQIRIAAGFDFLTSRVAYKLGLTGPAVTVQTACSTSLVAVHTAVQSLLAGECDLALAGGITLHVPFPVDETEDGIIAPDGFCRAFDADARGTVPSDGAGIVALKRLEDALADGDTVHAVILGSAVTNDGFGKVGFTAPSVDGQAAAIRAAHLVSDVDARSIGYVEAHGTGTPVGDPIEVAALTKAFGADETGYCVLGSVKSSIGHTDAAAGVIGLIKTVLALREESIPATAHFRAPNPLIDFGSSPFVVRGTATPWPRGTEPRRAGVNSLGIGGTNAHVVLEEAPVQATTPGRPYQVLPVSARTPEALAAAVARLDTRAHDADTAWTLQTGRRVFEHRAFGVVHDGEPITWSSGPVAPTGGVAFLFPGQGGQHVGMARGLYRDEPVFRAEFDRCAELARPELDVDLRTVVFEGDPADLLSTMDIGQPAVFGVEYALAKLLISWGITPKVVAGHSLGAYAAAAIAGVLSLPDAMALVLERGRLLGAVPDGAMLAVSLPERDVLGLLGDELSLAALNSFDQCVVSGPAPAVDAVRRRLLADGVEARPLRISTAAHSKLVDPVLADYEKRVAKVHLRPPAIPWISDRTGRFVGADEAIDPAFWSAHLREAVRFADTLDTLLRHDDSVLVEIGPGRTLTGLARRHPTRVGDRAVVPTMPHPADETPGPAVLMSALGTLWQAGVPVDWAAVHGTPRRRVPVPTYPFQGRRFRLDVDDEPEHVVEVGSTTTATPTESAVAAAFGTILGLRTVDLEDDFFDLGGDSMLAARVVGLIRRDLGAEIGVRQVFRASTAAALARLIDGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F6</accession>
    <name>A0A7W7T2F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8999" checksum="1E95F162E5EEB6EB" modified="2021-06-02" version="1">MRPEWHDGVDPVFMGDLLLCAALEGRLVMSRAQADPVIADLRHTLADLRDRAEPLDDTWAQALVELPKYIEALRIAAGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T323</accession>
    <name>A0A7W7T323_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase RsbU (Regulator of sigma subunit)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="24"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="400" mass="42634" checksum="C0DA40A89D398DE0" modified="2021-06-02" version="1">MDDGRESRLRVLEAVTDRSLRDHDPETLFEVLLRRVRDLFSVDTATVLLSDAGGGHLVARAASGIEEEVFHGFRVPVGAGFAGRVALTREPVAIDRVDESTVLNPLLWQRGLRALLGVPMLAHGDLVGVLHVGSTVDRRFTDEEAVLLQLVADRLATAVHEHRSRSTRVAAALLQDSLLPERLPTSDDWELAARYVPGADSGVGGDWYDVFDLPGGRIGLVIGDVVGSGLPAAIVMGRLRSALRAYALEFADPAEVLGKLDRKAGHFEHNTMATVGYAVLDTTTHRVRLALAGHLPPVLAVPGEPTRFVDVPVGPPIGYDLAPTGRVGTSVALPPGALVVLYTDGLVERRGQDLDARLDALREAVCASAPEAACVRIMGALVGHEPGTDDIALLALRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T393</accession>
    <name>A0A7W7T393_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="647" mass="71172" checksum="AB1F9614587374D9" modified="2021-06-02" version="1">MGLRRAVGIGALVAMIAVLVAAYGGLVPWDEDARKPVVDVANIGSPLLAALAILTALPVRRPRRALDSTPDQVRSAREVVARDVRRWVEREVRHQELDASALVNLRVPGRHDEAPTVDDLVGLVTGGRLLITGAPGTGKSSAALLVVDRLLRDADHAGPVPVVFDIPVWDPELHALEDWLVGRLAFDHRLADDTHYGSRAARYLVVDGHVLPVLDGIDELAPAAEKAVHAFLEHWPHPVLVTRRWAAGVNQLARDLDLRLVKVVEIAPETALAHLAAKDRRWQAVLDLPVKARSRSGLVNALRTPLMVFLAREVTRVGAEPVGLVDRFRTRVEAEDYLLAHFVPAVFEACHRRRGRLSKAEAALVPRRTRSWSPRRAERWLRFLASRATHDEGRSVRWWRLWETTSSLRFAFFLVGFVAPLATGSLINLVRSGSPLPGTTALLIAYTLSATLAFMPVRRLRSELRKEPALDLGTSIGSLVAVLVGLGLTRALGPVVGVVGALVAFGLVFKVSHVADLRTRDGEVVMDPSALMRRLRTTALTGACCYAVAMVVVVSWWYRFVPELLLVGLAIALAALRMSLWGVFVAVRVRSAVAGRLPWRLMRFLRDADALGVLRRTGPTFLFRHERLRVALADKDDADKDDADKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3J0</accession>
    <name>A0A7W7T3J0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cellobiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="30919" checksum="D986762BCA98722F" modified="2021-06-02" version="1">MAPFFVLFAVFGVYPSARTAWMSLHRWDLLAGPVRFTGLDNYARLVSDPDFYNALGNTASIFVLATVPQLLAALGIAALLDRSGRGWQAVVLLPNAVPVVAVALVFTQLFGRDQGFVAWVLSWFGADPVDWQTRAWSAHLGVAIMVIWRWTGYNALLYLAAMRSVPRQLYEAAALDGASRLRMFRSITLPGIRPTLVFTVVVAAIGGLQLFAEPRLFGSGVSTAIYGGDDRQFQTLVMYLYENGFERFDAGYAATVSWVLFVLCAVLASVNALLVRGLVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T1</accession>
    <name>A0A7W7T3T1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="268" mass="28855" checksum="BAAA54B7B6BE9979" modified="2021-06-02" version="1">MTTTAAILDVPGAHLYHEVRGSGPLVVLVGAPMDANPFTPLAELLAVDHTVVTTDPRGINRSTVDDPDADATLDLRASDLAALIRHVDAGPAVVLGSSGGAVSTLALAQAYPDLVRVAIAHEPPLTEVLDDREELHRRTDDIIATHQGGDVLGAWRKFFVLANIDLPEPVFLQMFGGERTPQEIADDDFQHNHMMRPTTRWQPDVAVLRSIATRIVIGIGAESGGQFCERTSIALGRLLDVEPTIFPGGHIGFAEQPEAFEKVFRSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U8</accession>
    <name>A0A7W7T3U8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="21811" checksum="B3BDB25B58563457" modified="2021-06-02" version="1">MAHIALFGATGTIGARILDEALARGHRVTALLRDPAKLEKEHEALTKETVADVFQVTSAQVTGYDVVVSSVNGDVAGATRALVSALRGVEPTPRLIVVNGAGSLETAPGVKVWDTPGLPDFLLEIMHAHGDALDFLRTVEDVSWTAFSPAKTIAPGERTGTYRTGTDQVVSDEAGESKISAEDYAVALVDEIEKPAFLNQRFTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V2</accession>
    <name>A0A7W7T3V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="208" mass="22255" checksum="27BCE270F5A0DFF4" modified="2021-06-02" version="1">MNPKTITWSEAVELFERRGLPKSTWENLYEGEYVLYSGDAVVTGDFPLNSGEPQPWDLDYDIGYIVDGSLTVSGALYDFDDGAAALVVLGDLRATGFHTTCDTKLVVTGNTSADVVYGRYTDKYLVFGGDLRATVQVWWDECAPDQVDGTLAGSLVLPSYASDDDLGAAIVENAGSGTDLLVAEVLGEDGVDGEALLDRLVAGEPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3X4</accession>
    <name>A0A7W7T3X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase PknG</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031634">
        <property type="entry name" value="PknG_rubred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031636">
        <property type="entry name" value="PknG_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16919">
        <property type="entry name" value="PknG_rubred"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16918">
        <property type="entry name" value="PknG_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="799" mass="83479" checksum="A4397E11E324B416" modified="2021-06-02" version="1">MTALTCARSGCDGTIDGDGFCDRCGMEAPPPAAAGTGPLGSGAGGSAGTGSAGGGPSAVSGAGSTGPGPVGTGSAANGAGTAGPDGSTSSGTGTGPAATGSAARPGVGAATGPSGTAPGTSAWSAPTPVPEPRTGSGSAGSRSRRSSTRSAGRGRLGAGLVEVPLVPYRDPKDAVLTDPEVPEAKRYCSGCGRQVGRSRDGRPGRAEGFCAECGHRYSFTPKLVPGEVLHDQYEVLGCLAHGGLGWIYLAADHAVSDRWVVLKGLLDSGDEDAMAAAMAERRFLAEVEHPNIVKIHNFVRHADRATGELVDYIVMEYAGGTSVKDMINRLRLAGTGHESLPPAQAIAYALEVLPALGYLHDVGLLYCDFKPDNVIQTEEQLKLIDLGAVRRVDDRQSPIYGTIGYQAPEIGKAGPSVSSDLYTVGRALAVMTFRFDFRTTYKESLPEDVPLLDRHDSLRRFLVRATHREPRRRFSSAEEMAEQLTGVLREVLAQEDDVPRPGLSRRFTPERRAFGTDGVPDARAVAAALPVPNVDPADAAATFLMTASGDPDELRAAPAVTTEVRLRLARVLAEAGRTEEAAEELDHVPADWRGRWYRGVVALVAGRPDRARKLFDGVCDLLPGEAAPKLALAACAELAGEDAAPFHRVVWRTDRSYVSAGFGLARALLAVDDRDGAVAVLHSVPATSSHHLAAQLAAVRAQAGGGLSDVLAAGTRLAGLDLDAQRRAEITVELLAAALAAVRSTPPPPGRLLGFPLDEPGLRTGLERCYRQLARHADTPEERIALVDRANAVRPRTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z9</accession>
    <name>A0A7W7T3Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS domain S-box-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="293"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="4">
        <location>
            <begin position="784"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="874" mass="94417" checksum="F03FEBBCE9DFAF54" modified="2021-06-02" version="1">MDDSAEGGGRHLDRRLPERGLPGHRESACRELVDGVPVVVWEAEARTGELRYVSAAARRRFGQVVTRWRDFVHPDDLDEVTRTRRARIEDSTEYELTYRAVTASGDVVWLHERAAVTGSRLRGVLVDTTGQRVVEERERFLASLDRALQRLDDAEDVLATATRMLAEHLGVDRCVYARADEDDDLPAVDGFVLADFGAGAVKAMRAGRPWVVEDSESDPGLTRTDLVAYRRTGIRAVICLPLSRAGRFVGAMAASQATGRRWTDAEVALVSLVVNRCWESAQRADADRASREGERRLRLLVERATDVIWVLDRELRLVEVNPAACALLGYGRTELLDRHVGELVVSGPHADLRQRDTTEVWELRRADGGVVAVEMSVQDTPTGYQAIGRDVTERRRADAERDRRLHREHEIAETLQRSLLPHEPPALERLASAARYLPASSHSRIGGDWYDVLPVGATAVAMSVGDVVGKGPAAAAVMGQLRSALSGYLLDGHSPAAALERLDTFAARIDGAAGSTCACLVFDWDTGELRLAIAGHPAPLVVDAHGGRFRGTPAGPVLGSRGRAPYRDDVTTLPPGATVVLYTDGLVERRGEPIDFGLDRLLRVAAAGHARPPGELADAITDDLLAGGREDDVALVVARHLPEPLRRRVPAVPGELALMRRRVGRWAAQAGLAEDLAYDLQLALGEAAANAVDHAYPDGPGDFDYSVSVTTSGVRVRVSDQGRWRPSPVDPGHRGRGLGMIRMLSDEVLLDHDEHGTTVVFHLPTVSAAPRPVAHTGPFERVDVVVRLTGALDRTTIERTRADLLGRVAAGGVEIDLTAVEHLSSSGVALLLEAASAAGRRPVVTVRAGSAPARVLTLSGLTGPGGPLDVRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T471</accession>
    <name>A0A7W7T471_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ca2+-binding EF-hand superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="173" mass="18630" checksum="0B0947DE251E6431" modified="2021-06-02" version="1">MASDLQKRKTSVVFTAMDVNGDGFLERADFEALTDRWVAIRGEAGSDRLREIMTGWWAALSAASDGNRDGRVTLDEVLAVVDDLGTMLDLVTATAEAMFEAVDEDGDGLVSAAEYARMIHAWTGADAPTDVAFARLDLDGDGSLSRSEFVGHWVEFWAGNDGNAPGTYVFGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E9</accession>
    <name>A0A7W7T4E9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="618" mass="66580" checksum="14325016BE6127FC" modified="2021-06-02" version="1">MEVLIDGKPTPLGGAKQRATLAFLLMNPNRVVATSKLLKALWTDDMPKSARKILQNAVWGLRSLLTTDREGSAAALVTQPPGYLLQLDPEKIDMHVFLRLAKQGRAALATDPEAASRLLREALTLWQGPPLADLVETGVSWPELTSLQNTRLDAMEDYFEAELARGRHQAAIDELELMVESEPLRERSCGQLMLALYRSGRQADALRVYGRVRAALVGELGLEPGRELQKLQSAILSHDPGLAAVAPAPTAPEPRAATTVRRHAGGTGVAMIKVQPTGTHRDHPLLDLVARVTGEEVERFGGRVTASIGSVSLALFDQDGTGETGELRAVRAAAAITGRLPDDDRHALTFQAAVSAGSASAGQSGVRPVGTVAVSRATLADCENLLAHVPDGEIWVSERVHRSTGSAVAYQRVTEAWVPAWRVLDADPFHRHGDLSCDRRGHELGLLTGLLDLVRVRDQPHLVTLVGAPDTGKSRLVADFERLIAENRTADLLRTPIPADVAGDGIRAVQSRIVDVHCGAELGRPLVILIDDLHRASDALLDRVDDLVDCRRDLPLLVIGTTRPSLLDRRPEWGLGKHNATTITLSPPRVGGLPGRTAACVGHDRRLVRPDQAVPCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J4</accession>
    <name>A0A7W7T4J4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="162"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="364" mass="38936" checksum="4E72D2780E0546D6" modified="2021-06-02" version="1">MRFHSTLVDVSLAGAFAALTITTLVTRGVTDPKAYVLAALASLPLALRQRAPVLTMCVTVAASMAFALDTEGRFPDWGIAILVSLFTVATLRPRWVAAAMFTLATLSTALMFLYLRAVLVVPEVLQSSMVLLGAWALGESTRRWGLRMESLAERAARAADDERGRIARELHDVVAHHMSVVSLQAGVARYVLDSDPDTARTAITTVADTSREALSELRRLLVVLRIDDRGELAPQPGLADLDRLVDRTRQAGVPVAVEVLGTARTLPPGQDLCAYRVTQEALTNVLKHGGRATARITLDYRRDGVLTLHVVNDGSPPPPPPPGHTPHGIQGMRERAGLYGGVVEAGPVEGGFGVVLRLPTEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K7</accession>
    <name>A0A7W7T4K7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15227" checksum="199F924A31193A7C" modified="2021-06-02" version="1">MATLMAYYEAGEDPLPVDTTADLDALVKRMASEFAAQGGPVPPVAELFRPDPWAEGWVVVRLGIGADRGFIAHADADGSYITTNSRAPDGEPLIYDYQGHVREFPADAEIPLDQVVKAAHDLVTTDGRRSAAVTWRSWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M4</accession>
    <name>A0A7W7T4M4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="15102" checksum="77EC11D159DA4ABA" modified="2021-06-02" version="1">MSADLVTVWLFRNALGAADALDPLPGSWGVRDAAVVSWPLGAPSPLVERPGRIVGDTALGGAFWGLLCGLPLAAPMLCAGVGAGVGALVAWTTRPRLPRAIVDTVRGHVGPGRSALVLSTRGLSDDLLSRLRSSGGTQLPPTHAVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T2</accession>
    <name>A0A7W7T4T2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="40"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26559" checksum="B4BA742E8CA9EE30" modified="2021-06-02" version="1">MPDEIFDHPRLARIYDDFDGERDDLAAYLALADELGAKTVLDVGCGTGNLAILLAARGRAVTGVDPSSASLEIARAKPGAGDVTWLDGDATTLPAMAVDLATMTGNVAQVFLTDDEWLRTLRGIHAALRPGGHFVFETRRPRRRAWEDWGGGRRDFALDIPGVGRVEQFVEVTDVSLPLVSFTHTYRFAEDGFEITSPSTLRFRDRPELEESLATEGFLVLDVRDAPDRPGREFVFVARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T574</accession>
    <name>A0A7W7T574_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4775" checksum="7C8547426EA78AA6" modified="2021-06-02" version="1">MTVRLRLTAQQARDRLAEADDPVDGTPDEPVVDEDRPEDLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E8</accession>
    <name>A0A7W7T5E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="406" mass="42653" checksum="9589C1BB2B37B13E" modified="2021-06-02" version="1">MTAPVRIPADVDMHDRVLGPLTARQLAILAAAGAVLYLTWAATRAFMPIPVFLAFAVPVGAASAMLALGKRDGVPMDKLLVAAIRQRVAPRHRVAAPEGVRPAPAWLTPDTDQAAGRRKGGKSRTGQPEQVSPSALRLPAEAVTETGVVDLGTDGLAVIAVASTVNFALRTPNEQEALVASFGRYLHSLTAPVQVLVRTERLDLSTQIAELRERAGGLPHPALEAAAVEHADYLVQLGQQSDLLRRQVLLVLREPLGVAAPTDGLGGPGPMAVLSSMAGKRRKQAGEQVDAGTRRAAESRLVRRLGEAIELLSPAGIVVTPLDAGQATAVLASACNPDSLLPPSAGLAGADEVITTSGADLTEDDIDGGSYFAHRATMPSRAPSGRSEDRDEYGDDWDYEDERGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5F4</accession>
    <name>A0A7W7T5F4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_004287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="62"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="295"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="12">
        <location>
            <begin position="418"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="14">
        <location>
            <begin position="534"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="883"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="845"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4966928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="909" mass="97694" checksum="993EBB3A8FF0790F" modified="2021-06-02" version="1">MPKYVYDFAEGDLSMADLLGGKGANLAEMTVMGLPVPPGFTITTEACRAFLATGAVPEGLDGEVDEHLHALERAMGRKLGQADGPLLVAVRSGARFSMPGMMDTVLDIGLTDDSVAGLAAWAGDERLAWDSYRRLVQMFGTTVLGVEAEYFAAALRDAKRAKGATGDLGLDTDDLRVLTATFKDIVRDRTGRDFPQDPRAQLGMAITSVFASWHTDRARIYRRAEHIPEDLGTAVNVCAMVFGNLGDDSGTGVAFTRDPATGAPGVYGDYLPDAQGEDVVAGIRNTLPLHRLADLQPRAHERLMEIMAALEGRYRDLCDIEFTVERGKLWMLQTRVGKRTAAAAFRIADALREEGLIDADEALRRVTGAQLGRLMFPRFADTDRTPLATGVAASPGAAVGAVVFDSATAVRRGEEGTAVILVRRETDPDDLDGMIHARGVLTSRGGKTSHAAVVARGLGRTCVCGAESLTVDAEARRFTTADGTVVAEGDVISVDGTSGAVYAGGLPVVPSPVADYFEGRRPAEGDELLRAVDRIITHADRRRRLEVRANADTPEDAARARRLGATGIGLCRTEHMFLGDRRVLVERLILAADDNARAVALAALLPLQRNDFTRIFEEMDGLPVTIRLLDPPLHEFLPDRVGLTARVAVAKALGDTGAPEDLLRAVDRLHERNPMLGTRGVRLGLLIPELYDLQLRAIAEAVSARILVGGRPHVEIMVPLVGDARELEVVAAQARRTVADVARESGVDIRYRIGTMIELPRAAVTAGRIAATAGFFSFGTNDLTQTVWGFSRDDVEGSFFPTYLAKGVFTVSPFETLDREGVGRLIEIAVREGRDARPDLTVGVCGEHGGDPASIRFFHEAGLDYVSCSPFRVPVARLEAGRAAVGDADPTTAGKPPRQRRNPSPGHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G9</accession>
    <name>A0A7W7T5G9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ferric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="219"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="48871" checksum="4281009D0209B4BD" modified="2021-06-02" version="1">MTAARNPDAAVRLTAAGALYGVLTLVVFWWAARGGVQQLGTWESALASVGRLTGLVSSVLLLAQVVLMARLPVLERAFGQDRLAAVHRVVGFTSFDLMLAHLVLITWGYAAGDLTRTPATFWELVTEYPGMLLALAGTVCLVLAVVTSVKAARRAIRYESWHLLHLYAYLGVGLALPHQLWTGTDFRSSTAVTVAWWAAWGATVGAVLVWRVGVPVRRNMRHRLRVSHVVREGDGVHSVHLTGRALDRLAVDAGQFFGWRFLDRAGWTRGNPYSLSAAPDGRGLRITVKESGDNSARVAELRAGTRVVFEGPYGRLTGRARTRSKVVLIGAGVGIAPLRALAEGLAYAPGEVVVLHRFTGQPLFDAEFDELVRTRGLRLVRLPGRRRASGSWLGAGTPDVDDVAALRVLVPDLVDRDVYVCGPSGWTATVRRCAENAGAPADRVHVENFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M7</accession>
    <name>A0A7W7T5M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biotin transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="21933" checksum="548E95B2608B1D15" modified="2021-06-02" version="1">MLSLYHDVRSPVHAVPAGAKLAVLFVVGATVFFVRSVGALAGVLAVVVLLYALARVPVRVAWRQLAPVLPFAAAVVVAQTLVTDWWTALMVGERLLVVVGLAVLVTLTTRTSAMVDAVEAALRPLRPLGVRPERVGLLVAITLRFVPVIKAQVDQVRAAQKARGVERGISFLTPLLIKTLRLADALGEALDARGFDDPRPDANDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q2</accession>
    <name>A0A7W7T5Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14920" checksum="FABB04B0BED5082C" modified="2021-06-02" version="1">MSNHEPGRVFRQAWIDGVRRHHPGEPKPGYVTGWDDTPEWERSSAAAVYDQVRAFLTATEGRAVRLSRTQKGQFVASCWTGQIHRHFPDPKPSYVAEWNDLPTWQQETDADIFERIEQDHADSTSGDFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z4</accession>
    <name>A0A7W7T5Z4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan/xylan/chitin deacetylase (PgdA/CDA1 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM_fam5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="SSF51055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031461815" evidence="2">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="43"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="30625" checksum="7967A8C46F8C6410" modified="2021-06-02" version="1">MSRLGIGMAVLGAMAVLATVVTPASAAGGPTGEIVYSTRGDGRALALTFDDGPSPTWTPPLLDLLRERKVRAVFCVLGGEAQRHPDLVRRIAAEGHALCNHSMWHEDLAAKTPDEVAADLVATSDAIRKAAGDPNLPIPYYRAPFGSWGTTATVAASLGMSAAAWSVDPRDWDGSPADVLVDRLTAQLHPTAVILSHDGGDRGPTLTAYRTLIPRWQADGWRFDLPRLTGGPYPSLCTAPTWERDRSYPGGSRVSHEGHVYQANWWARVERPTTAPWVWSDLGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T642</accession>
    <name>A0A7W7T642_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_004046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017205">
        <property type="entry name" value="Sig_transdc_His_kinase_ChrS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037434">
        <property type="entry name" value="STHK_ChrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="307"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4966687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="42424" checksum="26DF1EA623AA4B39" modified="2021-06-02" version="1">MSDSLDAWERRLYVSGHAIPYAVLAMPTVVYLVLTQDPVGKRLLLTGVAIATALWMLWWFTLHPGWRARHGLMRVFVLGVLVAYAVLGISDEMFGFFSFAGYIYVTEVLPGREKVVGILVNAVLAATSLFGGLPAPEPGPIALYAALCVLFAAVATTFSLLGYVTSRQSQRRKEMVAELAAIVEENAGLHAQLLVQAREAGVLDERQRMAREIHDTLAQGFAGIVTQLQAVDSPSRHVETAIALARENLAEARRSVHALRPAALEGSDLPGALSDVVDGWAGRTGVSASVSCTGHARALHPEVEVTLLRTAQEALSNVAKHAGAARVGLTLSYMEDVVTLDVRDDGRGFDPAADAAGFGLVGMRQRASRLAGALVVESEAGMGTVVSVSVPAIPAEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T676</accession>
    <name>A0A7W7T676_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030741765" evidence="1">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="142" mass="15403" checksum="3ABDB023F328511B" modified="2021-06-02" version="1">MSIKRVLTTLGVVVAAVLAMVTVSTGTGFAEPTSAQAPVAVPGGGMSALVTYHWDCPGLVCERAIPPFPGGTMSIDVDANGQGKGTWLIFNKWNDQLCRTEFDLVAPAQSWTCGYLEPGNYRLFLVINNYQHTTYSWMAARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I9</accession>
    <name>A0A7W7T6I9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="36331" checksum="02B4FD2CACFE016E" modified="2021-06-02" version="1">MRLPHPRGPMSSVLIAALRTGRFDFLGSGRVTTSDVVGDEDLQLSLWMCYELHYRGFDDVDDTCEWSPEVIVFRGLLEKTFLAGLRAIAPVEDVTPEEVPDALADLVAADDGPPLAGYLQREATLDQFREFVALRSVYHLKEADPHSWAIPRLDGGAKAALVEIQADEYGGGRVERMHSELFRDLMRFLDLDDTYGHYVDQASAATLAVTNTISLFGLNRRLTGALVGHLAAFEMTSSLPNRRYGTGLRRLGGDARATRFYDEHVEADAVHEQIAAHDLCGSYAKAHPEAAGDVLFGAAACLSVEARFGGQLLHRWARGLPALLVPALGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M7</accession>
    <name>A0A7W7T6M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="21186" checksum="316EF5FDF9873653" modified="2021-06-02" version="1">MTSIDTITLDVADTAAAERFYAKAFDLDSLRFREAQEPTSGFRGFTLSLTVAQPGTVDSLIGSAVEAGATTIKPATKSFWGYGGVVQAPDGTIWKVATSAKKDTGPATRRIDGIVLLLGVADVPASKRFYVERGLTVDKSFGRMYAQFEPGTGPVSLGLYRRRALAKDAGVAPEGTGSHRLTIGGATFTDPDGFAWAEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6U6</accession>
    <name>A0A7W7T6U6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15556" checksum="EC86BB9D2E00A9DF" modified="2021-06-02" version="1">MIRRASNDDLSTLLPLVREFYAIDGHDYDEPVVTAALGPLLADDRHGQVWLFDRGYAVLTWGWSLESGGRDALLDEFYVADRGRGTGATVLTGLVDQARAAGARKIFLETEEPNDAARRFYRRHGFEPERSTWLSRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z0</accession>
    <name>A0A7W7T6Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
            <ecNumber evidence="1">2.7.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="32334" checksum="949DC4EAA6D16346" modified="2021-06-02" version="1">MLTIGLDVGGTSVRAGVVTGDGEVLDTVRAATPGGVAALEDAICGAIADLAARHPVTAVGLAVAGFVAADRRTVLFAPHLAWRRAPVAERVARRVGLPVVLEHDANAAAFAEYRFGAARGARVAVLVALGTGIGGALLVDGVLFRGAHGVAPELGHLRLVPDGRPCPCGRAGCWERYCSGTALATTAVELLARYPGSSTVLAREVVGNGRVVTGRRVAGAARDGDPVARRALADLARWLGDGLALVADVYDPEVVVVGGGVSESAPLFLDDARERYASVMTGAGHRPPARIRTAQLGDDAGLVGAAVLARESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7C8</accession>
    <name>A0A7W7T7C8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">[lysine-biosynthesis-protein LysW]--L-2-aminoadipate ligase</fullName>
            <ecNumber evidence="6">6.3.2.43</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004736</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.43" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="96"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="286" mass="29956" checksum="8CE7D5B8E3897558" modified="2021-06-02" version="1">MNPVGPRLGVLASRVRVEEKAIMAALDRRGVAFEHLDPRTLSVTGGAAWAGPEFVVNREVGHYRALYAASALEAAGATVLNSAAATHVSGDKWHTSAALLAAGLPTPATTLALTSEAALKALEEIGYPAVIKPLVGSWGRLVTKVADRDSAAAVLEHVEALPSPQSHVVYLQELVGRADRDIRVIVVGGEVVGATHRRGDEWRTNVARGAASEPCPLTDEITDLAVRAAAAVGADIAGVDLIEAEEGRLTVLEVNDRVEFKGFQSAHPGLDVADRIVDLLLSRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7M0</accession>
    <name>A0A7W7T7M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="248"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="35354" checksum="5AF0B70A399D18FF" modified="2021-06-02" version="1">MRRLPRYADLSLPPTLGLLTAGVAATHPAAPPLALAAALTLYYRRNHPIAVTAATLFLGAGIQLLAPRTALPYAALIAVATLTARKPPWVSLPALAATEAVIALNRLTMTTEETVFLMVVAVLPWTFGEVARNRRTAMEEAAKRAVSEEQARIARDLHDVIAHSLAVVVVQALAADDVFDHDPARAREALRAIDSAARATLDDLRTLLADVRPDPRGLSRLTDLVDPLRTAGLRVSVTARHPHLPADVDATAYRIVQEALTNTLRHADATAVDVTVSGDAAELVIEVRDDGRGGVGLGRGITGMKERAGLLGGTVTAGPGTSGGFHVTARLPLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T897</accession>
    <name>A0A7W7T897_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding LacI/PurR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="29836" checksum="171F0A87428784B2" modified="2021-06-02" version="1">MTRLEEVALEAGVSKSTVSRVVNGGPYVSARARSAVLAAIDRLGYRPNQAARSLAGNRTDCVGLVVGDRSFDAGLADLLRGVDTVLSGLGLRLVVSTGASVDGVDGVLRVGGGGVPAGVPVVSFGHAVGVPYVAVDDFSGGVAAVRHLVGRGRRRIAAIAGGGDVDRLNGWYRGMGRAGLSADLVVRAEADPASGARAMSVLLSSEPGLDGVFVGSDVLAYGALEVLRTRGLGVPSDVAVVGFGDLPSSSVVGLTAVRPDHESLGRSAAHLMATVLSGSPVPPFTLVPPSLVLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A4</accession>
    <name>A0A7W7T8A4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="108"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="34735" checksum="59957B618D3747A6" modified="2021-06-02" version="1">MTEIGSPVAQAPTPASAEAISQFDSTQARKQWQVILRRFLRHRAAVAGVIIFVVLVLFAFFGGLFWKYSFSELSLGRYKPPSGQHPFGTDRLGGDMVAQTIRGTQFSLQIAMIVAFLSTLIGVVLGALAGYLRGWVDTLISRFIDLILVIPSFVIAAVLARNSFAVGVNGSNNSNWIIVALYLGLISWLSIARVIRGMVLSLREKEFVEAARALGASTGRIVFRHILPNTIDVIIVNATLAVAQAVLLEAALSFIGLGVQTPDTSLGLMINQNKNELQLHPWLFFIPFTLIVLISLSVNFIGDGLRDAFDPRQKRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8H7</accession>
    <name>A0A7W7T8H7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YjeT (DUF2065 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031415013" evidence="2">
        <location>
            <begin position="29"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="471" mass="49300" checksum="346C57C697DCA564" modified="2021-06-02" version="1">MRWRRLGAAAVAVGVVLLVAPGVSDAAAEEGIGYTTPAQGYIAKPGNTDWVGSYIWRGKHVWCVQYALLAPDSDVEYSDGDELRTKAGADLPDDVASYISYLLLRYSTTTSADESAALAHLLHSWTAAPQPGLELDPDVATYLTVAYDEQFHYDGLPPTAQQAVNTLRQDAIANRGPWTVTATEPEDSQTIGTPGAWRIDVTKADDSPVRGAPLTVEVVGGELENGGTTGEFTTPTDGTALEVQVTPTEEEVSLVVKLDSPADRPVVHVPDQGQGAAMQRIVTTGGEKKLTAQAETVARTAPAEVRTVKTDSETGRPIGGVALRFTAGDGVSPAIGQDDRPLVGADDKPVVIQTADDGSITVPEVRTPQEVCVVEVAAPRGYEEDFDPNAPPKVCTTAQPGQKVDLALRNKPNKPIVPLKIPAGVDGSGVVATGASTTRTDAGALIGYGGGVLVAGVLLGAWVRRRATART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Q7</accession>
    <name>A0A7W7T8Q7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="9">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metG</name>
        <name evidence="13" type="ORF">F4559_005934</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="6"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="12">
        <location>
            <begin position="421"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="347"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4968575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="596" mass="66131" checksum="5F6BBDEE79A0D767" modified="2021-06-02" version="1">MSAPVLTAVAWPYANGPRHIGHVSGIGVPSDLFSRYLRMSGHRVLMVSGSDEHGTPTSVQADKEGVTPRQLVDKYHRVIAEDMRGLGVTYDLFTRTTTGNHYQVTQDVFTALWRNGYILPKTTTGAISPSTGRTLPDRYIEGTCPICGYDGARGDQCDNCGNQLDPAELRNPRSKINGETPKFVETEHLFLDLPAFTQVMGEYLGSRVDWRPNVIKFSSNLLGDLRPRAITRDLDWGVPIPLDGWRDQPLKRFYVWFDAVIGYLSASVEWARRSGNPDAWQEFWGKDAQSYYFMGKDNIVFHSLIWPSILYGQNGQGDKGGTPGRFGTLDVPTEVVSSEFLTMSGSKFSTSRGQVIYVNDFLREFGPDALRYFIAVAGPENQDTDFTWDEFVRRTNFELANEWGNLVNRSVSLAHKNNGAVPKPGTPTAADEELKALARGAFDVVGGHLRRSRFKAAVGEAMRVVGAANRYLSDQEPWKMKDDPDRRDTVLHTALQVVQDANTLLTPVMPHAAQKVHELLGGTGVWAAQPEIREVEDLDEAGREYPVITGDYTVEQAKWGSTPIEVGRPLDKPSPLFAKLDPELGETGPAWAPIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8U2</accession>
    <name>A0A7W7T8U2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="32467" checksum="B834011311E3DDAB" modified="2021-06-02" version="1">MAQGVLEIDRISKRYGEVVALADMTFDVRAGELFGFVGSNGAGKTTTMRIALGVLAADAGEVRWNGAPVTLDTRRRIGYMPEERGLYPKMKVHEQLVYLAELHGMTTDDAHRGADAWITRLGLRDRAGDEVQKLSLGNQQRVQLAAALVHDPDVLVLDEPFSGLDPVAVDVMSQVLREKAAQGVPVVFSSHQLDLVERLCDRVGIVRSGSLVACGTVDELRSGGTARLVVDAPDAGAGWASALPGVTSASYEGTRALLELAPDADDQVMLHAALATGPVREFSRQRPALTDLFRSVVAEEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T945</accession>
    <name>A0A7W7T945_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinogalactan oligomer/maltooligosaccharide transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="33305" checksum="91A45C2324F6FEB6" modified="2021-06-02" version="1">MRAFLSRHWYAYAMVLPVVLVVAVLVLFPLGQGVLFTFTDVDEGTIANPVLGRPATYEWVGLRNYAGILSGDPGYGAFWGTLGRTMVWTFGCVLCHYALGLGLALLLNRQVRGRAVYRALLILPWAVPAFVSAFAWRHLLNARYGIVNQVLRALGLPDPVWLGQSDWALVAVMVVNVWLGTPFMMVALLGGLQSIPTTLYEAAEVDGASPWQRFRHVTLPGLRAVSGTVVLLGVIWTFNMFAVVYLITGANPNTRLLVTYAFERFFSAASRDYAVASTYGVLILSVLLVFAAAYRRALREEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T946</accession>
    <name>A0A7W7T946_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="27225" checksum="0262420AC6EB7673" modified="2021-06-02" version="1">MTSDDLRARRAGSFGAHAHAYAEHRPDYPAAAVRWALAPLGAGRHEVLDLGAGTGKLAGGILAEGHRVTAVEPDEAMLSELVRRHGGVRALPGTAERIPLPAATVDAVLVGQAFHWFDPDRALAEIARVLRPGGVLAALWNDWDEDVDWVARFPRHTEGLPAGTTPTEDVPEHELFHDGAQRRFRHVLRRTADTLVAMLGTHSKLLVSPPEVRQAYEERVRAFLAAEPATASGEFDVPHVSDVWRLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T953</accession>
    <name>A0A7W7T953_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding SARP family transcriptional activator/tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="929" mass="101307" checksum="0626F6EDD914A683" modified="2021-06-02" version="1">MAEGRSGLEFGVLGPLQVLADGKPLPIGRKGMRGLLAMLVLDANRVVPIDGIVDCLWADDPPATARTIVHGYVSRLRRMLEEADPAGSARILTTPPGYQLLVDPWRLDFHRARQLVSSARGKPAPIRAQLLRESLGLWRGPVLGDVPGRPATTDLEELRLAALEERVEAELELGRHLELVGELRRLVDEYPFRERLVAHSMRALYRSGQRADALDAYQRFHRRVVDELGIDPGPELRVLHEQVLRDDPALGGEGDIAPVALVPPRAGVVVPALLPAAASGFIGRDDELARLDLLCAQRDLQATTIAVVAGAPGIGKSELVVTWGHRRAEWFPDGLLYASLNGFVPDRDPVEPGEVLGRFLHALGVPADGLPRDLDDRVGLYRSVLAKRRVLVVLDDAWDPEHVRLLLPPGAGSVVLVTSRRRLESLVVSNGARMLTLDTLREEESVRLVDSVVGKPVSEQEPTAVRMLVELCGNLPLALRIAAAKLVLSPEWTVEDLVVRLSHDDHRLRTLDLPETGVGVARALAVSYRNLPPELAETFRAAGLVPGRWVSPHAIAAVCGTDLGTAQNRLADLADAHLVVEQWRGGYVLHDLVRLYAREVVGPAGPDLRRLVDHYLAACDHARRLIRPVADGLDFSGGDTPAARPATAGQALSWFDKEWPNLIALVHAGAEAGLHRQVWQLVRLVHTYCVTRPAGREWQAIAEFGLASARIAADRRGEMLVLHAMHEVDKRAGSSRGRLADARRAYAIAADLGEPRYLVMALDQLACALTAEDRDKEALACYREAVEVARGDGDALGEATVLDDLAQAERKLGRLEKAARHQFEAMEVHHRNGDERAFVVAVNNLAGLYADLGLLAEAEENARQGVELARGGAMRFEEAFGRLVLGGVLARRGEVVAAQAELAESLRLFERLGSARARQVRSALEALDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C3</accession>
    <name>A0A7W7T9C3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphogluconate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">edd</name>
        <name evidence="7" type="ORF">F4559_005039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="4.2.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; Entner-Doudoroff pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.12" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00226"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004456">
        <property type="term" value="F:phosphogluconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046177">
        <property type="term" value="P:D-gluconate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009255">
        <property type="term" value="P:Entner-Doudoroff pathway through 6-phosphogluconate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02094">
        <property type="entry name" value="Edd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004786">
        <property type="entry name" value="6-phosphgluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43661:SF1">
        <property type="entry name" value="PTHR43661:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01196">
        <property type="entry name" value="edd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="618" mass="64829" checksum="6F94851C1171F36A" modified="2021-06-02" version="1">MTTHPVVAEVTARIAARSAASRTAYLDRVTLAAQDGPTRRDLACSNLAHGFAGITGGDKDLLRANRRPNVAIVSAYNDMLSAHQPMHEYPDWIKGAARLAGGVAQFAGGVPAMCDGITQGRAGMELSLFSRDVIAMATAVALSHDMFDAGLLLGVCDKIVPGLLIGALSFGHLPAILVPAGPMHSGLPNKEKARVRQLYAEGKATREDLLDAEAASYHSPGTCTFYGTANSNQLVVEVMGLHLPGASFVPPGTRLRRALTEEAARRAVEISRGDEYTPIAHVVDEKAVVNGVVALLATGGSTNHTMHLVAIASAAGIELTWDDFDDLSSVVPLLTRVYPNGSADINHFQAAGGVQFLVDTLLDAGLLHEDVRTVAGPGLGRYRREPVLVEGALTWRDGPGRSLDTYVLRPATDPFARDGGLRTLSGNLGRAVIKVSAVAAEHRVVEAPARVFTSQEAFGVAFKAGELDRDVVVVVRQQGPRANGMPELHKLVPALGVLMDRGFKVALVTDGRMSGASGKIPAAIQVTPEAAVGGPLALVRDGDPVRLDAVTGTLEVLADLAVREPVDFPPGADAWVGTGRELFGALRHAVGPADRGASVFGPIAASHFAGRTTQEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I8</accession>
    <name>A0A7W7T9I8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol alpha-1,6-mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="176"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="369" mass="39297" checksum="D0475F538C4C888A" modified="2021-06-02" version="1">MRRTLLVTNDFPPRHGGIQAYLHAFARRLPELVVYAPAWEGAAEFDANQPFEVVRHGGTLMLPTPDVIRKAADLRRATDCSTVWFGAAAPLALMAPALGADRVVASTHGHEVGWSMLPGARQALRAIGSTSDVVTYVSRYTRSRFAAAFGPMAALEHLPSGVDTGVFAPDPAARAEIRARYGLGDRPVVVCVSRLVARKGQDVLVRALPQIRDSAPDAALLIVGDGGYRSTLERLAAAADVTDHVVFTGPVPWEELPAHYNAGDVFAMPCRTRGKGLDVEGLGLVYLEASATGLPVVAGRSGGAPETVRDGVTGNVVDGRSVDDVAKAVGTLLADRDTARLMGAAGRDWVSREWRWDTLANRLSHLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAB7</accession>
    <name>A0A7W7TAB7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">clpB</name>
        <name evidence="13" type="ORF">F4559_006816</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4969457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="860" mass="93057" checksum="CF2F7A98EA97C11B" modified="2021-06-02" version="1">MDAFNPTTKTQQAVSAAVQAATVAGNPDVSSVHLLGALLAQGDGIASPLLTAVGADPSRVHADLDRLARALPAASGSSVSAPQLSRDALRVLTKAQELATGMGDEYVSTEHLLVGLAEHGGQVADLLRGHGATPDALREAFGRVRGSARVTSPDPEGTYKALEKYGVDLTERARKGELDPVIGRDTEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVAGDVPESLKGKRVVALDLGAMVAGAKYRGEFEERLKAVLKEITDSAGQVITFIDELHTIVGAGATGDSAMDAGNMIKPMLARGELRMVGATTLDEYREHVEKDPALERRFQQVVVGEPSVADTVGILRGLKDRYEVHHGVRITDAALVAAATLSDRYITARFLPDKAIDLVDESASRLRMEIDSRPVEIDEVERAVRRLEIEEMALAKESDAASVERLAALRAELAEKRETLSGLTARWQNEKGSIEKVRELKEQLETLRGESERAERDGDLGRAAELRYGRIPALEKELDEAARTTQDAAVMLKEEVGPDDIADVVAAWTGIPAGRLLEGETAKLLRMEEELGHRVVGQAEAVRVVSDAVRRTRAGVADPDRPTGSFLFLGPTGVGKTELAKALAGFLFDDERAMIRIDMSEYSEKHSVARLVGAPPGYVGYDQGGQLTESVRRRPYSVVLLDEVEKAHPDVFDVLLQVLDDGRLTDGQGRTVDFRNTILVLTSNLGSQVIADAALDERGRRDAVMTVVRSHFKPEFLNRLDDVVVFRALETEELTSIVDIQVDRLGGRLAQRRLTLEVTPAAREWLALNGFDPVYGARPLRRLVQSSIGDQLAKELLAGEVRDGDTVKVDVIPDQSGLIVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH9</accession>
    <name>A0A7W7TAH9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="300" mass="33197" checksum="A3ECE8A7FCC554F8" modified="2021-06-02" version="1">MGQLWIAGCVVIVTAVVLASLSLRRRGSMLPATLLGSIGLFLLVTGWLFAVDPNAPKNEAIKTGGLAGGAVVALYALWLNDRRRRTDEERQAIETRRHELENARAEHDRSRVADERFARAIELLGHETEQVRSGALHALAGLARNRDEYRQTVLDVLCAYLRRPFRRGKSDDPELQVRHTAQLLINNLLPGLRDADAQHHVLNLTGAYLEYFDISERQVGTLLVRGATFSHSTSFRGLVVHGDAYFTESKCKGRLRLDNAVFHGKAWFSKVDASEGEVVLTGARFLGETKFAGSTGLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCE0</accession>
    <name>A0A7W7TCE0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="79"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="360" mass="38607" checksum="FB61F6C115284D26" modified="2021-06-02" version="1">MTETVLRPAAEQQYAAELTALAATDDRPRPPRWRMSPQAVVRYLLGGTLSDGTVITPKYIGDRRLVEVAVGTLVTDRALLLVGVPGTAKSWLSEHVAAAVSGDSTLVVQGTAGTGEDQVRYGWNYARLIAEGPSEAAVVASPVLKAMRTGAVARIEELTRMPAEVQDSFITILSEKTLPIPELGTQVQAVPGFTVIATANDRDRGVNQMSSALARRFNTVVLPPPATEDDEVRIVSSRAEQLGRALDLPARPPALDEVRRIVRIFRELRNGSTVDGRTQLKKPSGSLSTAEAISVVAGGMALAGHFGDGTITADEVASGLLGAVVKDRVSDTAAWQEYLETVVKERADWRDLYRACRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCM6</accession>
    <name>A0A7W7TCM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="245"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="439" mass="44952" checksum="E9AC4967C1FE4E30" modified="2021-06-02" version="1">MTRGVTTEKHHLGVRRLLRIADFRRLLLSRLAAQWGDGLFQAGLAGAVLFNPERQSDPLDIAAGFAVLLLPYSIVGPFAGALLDRWDRRRVLVVANLVRGVFVLLTAMAVGAGLEGVPLYAAALIVTGVSRFVGSGSSASLPHVVTEDHLVEANAFVSTLGALTAVFGAGCAIGLRVALGAGDGGSSWTTATAVVGSLLAAAIASRFARGVLGPDEVDEPSGAFAAIARGLLDGARAAARTPSVVAALFALLAHRVGFGISLLLTLLLMRNTLQDFGPLKAGIAGLGEVAVSGGLGVLLAGIFTDRVVDRLGARRTVLCALGLAAAAQGLAAVIELVLGLPVLLPTVLCAAFFLTLGGQVVKLCVDAAVQSDIGDETRGRVFALYDTLFNTTQVVAIAIAAALVPLDGRSPGLVLAATATYLVGAAGYLLLSRQSVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT61</accession>
    <name>A0A7W7WT61_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="328" mass="34528" checksum="CA41E71F341649F0" modified="2021-06-02" version="1">MDHLDIVRAAVRPVKKLVEGDFLARPGVVGVDIGHKVVRGRRTGRLAIVVYVRRKRPSGHLTIPSDVLGVLTDVVQDTFVPHHTVARPEGVSGAERHELLQGGIGVGPCRAVRLVPPDVPSIGDYLVAGTMGAFVTPRDKRSVMGLTAFHVACVDDAWAIGDPMVHPSRVDGGHPVRDRFGTLARCALSGRVDAAAIQLTTPHWRAEVVGAGPIDGHAAAHEHQRVRKRGRTTALTAGEVASTDAVITLDFGQGLGVRTLRDQIRVEGPFGDHGDSGAVLLDDANRVVGLYCGGSALRAFANPIGPVLDQLDVSLLGGSVPPQPGHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTA8</accession>
    <name>A0A7W7WTA8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">F4559_000258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="179" mass="19637" checksum="8C5441513289FCEB" modified="2021-06-02" version="1">MSRIGKLPITVPSGVDVKIEGQEVSIKGPKGTLELTIAEPIFLERAEDGTLEVKRPNDERRSRSLHGLSRTLVQNMVVGVTQGYEKKMEIHGVGYRVALKGSDLEFALGYSHPVKVEAPEGITFAVETPTRFSVSGIDKQLVGEIAANIRKLRKPDPYKGKGVRYAGEKIRRKVGKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP9</accession>
    <name>A0A7W7WTP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015805222.1">
        <property type="nucleotide sequence ID" value="NZ_JACHJS010000001.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21226" checksum="7B662A489D3B49C7" modified="2021-06-02" version="1">MTTVLICDDRRSVREGLTRVMSAVPGVSRIDCVAHGDELLARFSRQPVDVVLVGTQRAVPTGVEATRRLVSANPQANVIVFGAPDDAGSIAAAIAGGARGYLRWDASRPELVAALAHTLASTSVPAPRQPSDPGVQLTERELQVLRGMSQGKSNGQIGRELYLSEDTVKTHARRLFRKLGVRDRAQAVAHGFRRGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTS2</accession>
    <name>A0A7W7WTS2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="10645" checksum="5356B1DEBBF35268" modified="2021-06-02" version="1">MTFEAYLGFTGQTATVFASGELGAETAPVLRSLVERAAAGPVARLVLDLTGLSAMSSAGVRVLAFAQQSLPSGVPIIVVGARPEVVEIIRLAGFDQAVSLSPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTW0</accession>
    <name>A0A7W7WTW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7933" checksum="681EB59BCFD0B071" modified="2021-06-02" version="1">MTDNNTEPSFYTVAEAAHLLRVSPMTLYRAIHDNELPATRIRTRLLISAHTIHNLTAHTKEAPDARTPATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTX7</accession>
    <name>A0A7W7WTX7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="220" mass="23478" checksum="6CA358BCFC4CB378" modified="2021-06-02" version="1">MAAEAEQAKAVLHQVVDGAARLCAVVEKIISDATTLLTTLTGSARSPTIPQLARTPENPHPTPFSASPSVDDTSSVVPPERIERLRGELPDDVPPADRRPPGAPRPKTHGRWIGPDGRTHAVQSGEDGMYPESATALADLGFRRKLTRASDVEMKLAAHMRNHGIHSATLVINNTPCVGEFGCDRLVPVLLPAGATLTVHGANGFEKTYRGGAKPPWRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU23</accession>
    <name>A0A7W7WU23_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031077149" evidence="1">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="12549" checksum="E19A39A1073498DC" modified="2021-06-02" version="1">MPALVTTEANRLLDASLGVATYTAPTGSMKVALATSASSASAAGTEVSGGSYARQNVTFGSASAGSTSNTGAVTFTSMPAATVTHVDIYDSNGTPRRAWYGALTASKTTASGDTLSFAIGALTISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU97</accession>
    <name>A0A7W7WU97_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017186">
        <property type="term" value="P:peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031235004" evidence="1">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="27082" checksum="00566C0111AA3E80" modified="2021-06-02" version="1">MKSTVNVVVSVGVLVLVVSCGTPERTGTALPVSVSTRVSAAAVGPVSVRTVVVEAVPSDGADVRGLGVVGDFLVEAVETGAGAVVRVVDAAGTVVRGVDVARAGAVAGVHGGLWQLDSAGRAAIARDPETLVETRRVGVDDARGGLCFTGRHLVHASTADRLVLRDPVTFDEVGAVVLGGHWSAGRLVASVACAGSRAWVLLAGSDWVVEVDLDRSAVVAVASLTRVRADDPEVAGVFGAITAVGDGLWVAGSFRHRFRVRLEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG8</accession>
    <name>A0A7W7WUG8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="40036" checksum="25107159C1F4B68B" modified="2021-06-02" version="1">MRRVGALADGLRDWWEHAKTWQRYLVYLAAIGLSLVLPAPWIGSFMSPGADWTTVLIYPIGTYILLAVGLNVVVGQAGLLDLGFVAFFAIGGYSVAYYGTHYGWNYWATVAFGIILAAVSGVILGAPTLRLRGDYLAIVTLGFGEIVRITANNTDEIGGARGIANIPHPPPVFGTKFLLDPAPYYYLIVAAIVLVIIFSVRLQKSRVGRAWAAIREDEDAAELMGVPTFKFKLLAFAIGAMIGGLAGGIYAGKAVFIEPNTFPFILSATILAAVVLGGSGNLPGVILGAFVIGWLPERFREVEWLKEALGRDPAEYRILLFGGVLVLMMALRPEGLLPSRRRKAELHEGTGGMGTLGAEVPGPDTDVATSEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV86</accession>
    <name>A0A7W7WV86_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fused isobutyryl-CoA mutase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Isobutyryl-CoA mutase</fullName>
                <shortName evidence="9">ICM</shortName>
                <ecNumber evidence="9">5.4.99.13</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">P-loop GTPase</fullName>
                <ecNumber evidence="9">3.6.5.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">G-protein chaperone</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">icmF</name>
        <name evidence="11" type="ORF">F4559_002389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2-methylpropanoyl-CoA = butanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:13141"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="EC" id="5.4.99.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; propanoyl-CoA degradation; succinyl-CoA from propanoyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the IcmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.13" evidence="9"/>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00945">
        <property type="reaction ID" value="UER00910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047727">
        <property type="term" value="F:isobutyryl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034784">
        <property type="term" value="F:pivalyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02050">
        <property type="entry name" value="IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033669">
        <property type="entry name" value="IcmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="8 9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="10">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="9">
        <location>
            <begin position="405"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="960"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1079"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4965030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118417" checksum="0F93F3089D3C761F" modified="2021-06-02" version="1">MSAPSTLHKPVHPVRFVTAASLFDGHDAAINIMRRILQTQGVEVVHLGHNRSVREVVAAAVQEDVQGIAISAYQGGHVEYFSYLVELLNERGAGHIRVYGGGGGVIVPEEIELLHSRGVARIFSPADGQKLGLARMINTMVEECDVDLAERLPDSWDGLLAGGEDDLSRAITLIEAGRLPDDVRARLVKAADARAVPVLGITGTGGSGKSSLTDELVRRFRLDQQDKLRIAVLAIDPTRRRGGGALLGDRIRMNCLEGDRVFFRSLATRRAGTEVPDGLSDAILACKAAGFDLVVVETPGIGQGDAAIVPYVDHSLYVMTPEFGAASQLEKIDMLDYADAVAINKFERRGAEDARRDVARQLVRNREAFGSSWEDMPVFGTSAATFNDDGVTALYQHLRDALGARGLGLAEGTLPVVEGRVSTAAATVVPASKARYLAEIAETVRGYHRATETHVDAVRRVAHLAAAREELERAGLDTADLTTVLESARRHVDGIAAELLAAWPRVVEDYSGDELVVRVRDKEIHTRLTRETLSGNKIRRVSLPGFDDDGTLLRFLRKENLPGYFPYTAGVFPFKRDGEDPARMFAGEGDAFRTNRRFKYLSSGSEATRLSTAFDSVTLYGRDPDTPPDVYGKVGTSGVSIATLDDMKALYDGFDLTAPTTSVSMTINGPAPTILAFFLNTVIDQRVDRFRADEGREPTAEEAADLAAWALANVRGTVQADILKEDQGQNTCIFSTEFSLRMMADIQEWFIGRKVRNFYSVSISGYHIAEAGANPISQLAFTLANGFTYVESYLARGMSIDDFAPNLSFFFSNGMDAEYSVIGRVARRIWAVAMRERYGANDRSQKFKYHVQTSGRSLHAQEMDFNDIRTTLQALCALYDNCNSLHTNAYDEAITTPTESSVRRAMAIQLIINKEWGLSMNENPLQGSFVVDELTDLVEEAVLLEFDRLSERGGVLGAMETGYQRGRIQDESMLYEQRKHDGTLPLIGVNTFLPADGSREQVTIELARATEDEKRSQVERTRAFAAAHATEAEPALRRLKEAAQAGENVFAVLMDAARVCTLGQVTEAFFEVGGQYRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV90</accession>
    <name>A0A7W7WV90_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23574" checksum="27707D615E7E88FF" modified="2021-06-02" version="1">MARVFLVDDHEVVRIGVRELLNSGDDLEVVGEAGSVAEALARVPGSGADVAVLDVRLPDGNGIELCRELRSLMPELHCLMLTSFTDDEALFDAIMAGASGFVLKRILGNDLHNAVRTVAAGGSLLDARSTAALLDRIRREREQGDPLRVLTDQERVVLDHIGQGLTNRQIAEKMFLAEKTVKNYVSHLLAKLGLERRTQAAVLSNKLRKPAIHPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA0</accession>
    <name>A0A7W7WVA0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide-binding universal stress UspA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="146"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="285" mass="28800" checksum="C0CDBC7CF236B32C" modified="2021-06-02" version="1">MGAPILVGVDGSESALDAVRWAAAEAARRGVGLDLVHVYPTPVRGYPQVVLTGGEVRRALEEAGREHLERARALVADVPVTVEVVPGDAAATLVGRSAAASCVVVGSRGLGGFTGLLIGSVAVALAAHARCPVVVVRGTEAVDGPVVVGVDGSPTAEAAVAYAFEEASLRGVGLVAVLAWTDALVDGPLGERFGADWAAVEAGEHRVLAERLAGWGAKYPDVAVTRAVVRELPVRALLDHAAGASLLVAGTRGRGGFAGLLLGSTSQALIHHAPCPLAVVRPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC8</accession>
    <name>A0A7W7WVC8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall-associated NlpC family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031481724" evidence="3">
        <location>
            <begin position="25"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="291"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="429" mass="45181" checksum="0EC96B702F127E75" modified="2021-06-02" version="1">MNRWPVSVLAALFAVFVLIGSAGAVPPPPPNPGDDEISEGRRQADEKAARVGELTGQLTEATARLRALDDEVAAKMEFANKARVDLEIAQGEADRARRDADAAAVEAKAAGQAVEDTRLLLDEFAAASYQQGSVVGSVSAFFGSKSPEELLARAQLLSAVGGSSLNAMEEYERDRADKANKDSAARAALDAADRKQAAADDAKHTADAAQADAVRARSEQSEKAAALEQQRATVQGELDEALGAVGGLEAQREQYEQWSEQKRREEEAAAQQAASYTPPPVPAGGGPAPVGGDVETVVARATMHLGVRYSWGGGNYDGPTTGIRDGGVADSYGDYYSVGFDCSGLMMFAFAGVGVYLPHYSGYQYTAGRQVPLAQARRGDMLFWGPGGGTHVALYLGDGMMIEAPFSGASVRIAPVRYGGIMPYVTRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD6</accession>
    <name>A0A7W7WVD6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041356">
        <property type="entry name" value="PGM1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040754">
        <property type="entry name" value="PreAtp-grasp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18105">
        <property type="entry name" value="PGM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18604">
        <property type="entry name" value="PreAtp-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="155"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="442" mass="46812" checksum="BE58FAFB37B7DB08" modified="2021-06-02" version="1">MAKLIIANSRTEEMVGDLSLLTPDERVAGGWGAQRLFWFASDGDVLVLPWVAQDRYVDYVLGLTGTDRASLTLVVPPTGYLGEELLTPDRLADEGFRARLREALAGKGIDRIVTAYDDAYVVDLAKHLGIEHALPGFAFSEQGGDALVNSKAAFRAVAAGVGVAIAPGTIAGRPELAESTIGAILGRGDSVIVKKEFAGGGFGNEILATDATVRPAGARNVVLLADADAIKAYVAEKWSWLTGGRDDRLVIEQYFTGSATVYAEFVVADDASHLLGTGEILMEPVAIGEIVPPRSITPEQHVELVDAGRRLCDAFRGLGYRGNISADAIRTGDGRIVFSETNGRLTGSTHLHAVLRDRMLRPDFRGERVMVERAVWSVPSFEGAVDALVAAGLAFDPETGTGVVLTGNYVPVNGKVMYCVVGKDFESAEAVAASLAGLAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD9</accession>
    <name>A0A7W7WVD9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030618749" evidence="1">
        <location>
            <begin position="28"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="358" mass="38482" checksum="4EE8E61DC9F76474" modified="2021-06-02" version="1">MNVVKRRLSIGLAVVLLLAVVAVVVWGRPGGGESDATATTTVRGVVGSEKLAFFADRRVVEVFARNGLKVEVDPAGSRQIATTVDLGRYEFAFPSSSPAAQKIQRDRNVTAVYTPFQSPMAVATFEPIAALLESAGVVRKGAGDYRVVDVAKYLEITGTRWDQLPGNTAFPARKNVLLTTTDPAESNSAAMYLAIASFVANGNAVVGTPDQEEKVAPVVGKLFQDQGYKQNSTEGPFEDYLAAGMGKAPLVLVYESQYVDRLVRGDGSIRPDMRLLYPAPTVYSKHTLVPLSGNGDRVGKLLATDPELGRLAATFGFRTADPRHFAEVVGDKVPADLVDVVEPPSFDTLERLLDRIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVH1</accession>
    <name>A0A7W7WVH1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031365986" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="73"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19060" checksum="F3FBCB676CF7378C" modified="2021-06-02" version="1">MSMRVIVAAAAGSLAVLLSAAPAQAQIASPTDAVVTSVAVLGSSDRADSGEQGSVGVATLSQLHNRGLPGNWCLANRHPKVFMWECNSSYKDQRWTLNGKGQLVNAASGKCLAMHANGHVFTHTCTASYTDQRWYKHVKTGGYQYENKSHHGNCLAAHNDREVFGWRCDNAYPDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVP1</accession>
    <name>A0A7W7WVP1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="8995" checksum="9AE839357254BF99" modified="2021-06-02" version="1">MDVPDRSTGKGALWTALRWVVLGAFACTAAVIALLVGRAVLSAFGSVFDPHGYGMFAGILFSVVLTPVAVALWALYRSLRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVT1</accession>
    <name>A0A7W7WVT1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP:flavonoid glycosyltransferase YjiC (YdhE family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="383" mass="40236" checksum="C90DB43E1DA2D4EE" modified="2021-06-02" version="1">MRILFSSLGTHGHTYPLIPLAIAARAQGDEVVFATDKAFTDALAPYDVEVVQAGADLRSAFALALGGDATELRPTEVDMEVILRMFGSTLPRRFAADLEPVLADFQPDLVVHEVGNPGAAFAAERAGISRLCHGFGRAWVPTEQNDDLGRHLRETAADLGVSFDEAHPMVAGSPYVDIAPPSFQIKEFLASGVEIVPLRPTPFAERGEVPDWVVAHERPLVYLTLGTAFGDIGVLRTAIAGLAALDVRVLVATGPTVDVAALGEVPDNVELSAWVPQADLLPHTDLVVHHGGSGTTIGAFAAGRPQLVLPQGADQFANAEAVVEGGLGDQLLGDALTAEAITAAARRLLADQAVRAAASAIQGEVEAMPAPAEVARRLPEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV8</accession>
    <name>A0A7W7WVV8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA invertase Pin-like site-specific DNA recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="1">
        <location>
            <begin position="198"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="470" mass="52659" checksum="2D97E7275A5B4B20" modified="2021-06-02" version="1">MAAKTDDDQALFDEWLRSERDKAERGKSQDPYVHLGLRFAFYGRTSTTRHQDARSSRAWQLDVAWRVVDGHGTIVESFFDEGCSRLRSWDRRPEAARLLAALADPARRIEAVVLGEFERGFAGRQIWQVAKVLTEHDVRLWLPETDGPVDFDDPEHRNLMRTLAAQSQREAIRSRTRSLEAMRAQTREQGRYLGGRAPYGYRLVDGGPHPNRAHAKWGRRLQRLEPDPATAPHVTWIFEQRVAGRSLAGIARALNERGVPSPSQVDRDRNRHRVGSVWAVPTVAAILGNPRYTGRQVWNRVTNDRENTPLTSKRAAQRPNAIDRWAVSASLAHTPLVGTRVFTAAQKVRAARPTGDGGGRTYLLSGLAVCGICGRRMDSHWVHGRAGYRCRHGRTSASAPDPAADRMLYWREDVLLTRLATALASHRGDEVAARDVPGLLRESGRSVVCHRETAEWDARPVGKSPVQTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW01</accession>
    <name>A0A7W7WW01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030885960" evidence="1">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="14124" checksum="B6E3AD4A56D4C1D2" modified="2021-06-02" version="1">MACVLGVSVPLLQATTAVPAHADDRCTAGVICSATTNLSAFRVLAVEKWNCKEPCKGRQEWLAPGKSTPLLEDWDGFRVDSGWCYSYVMSPPNLLVRTYGRKNGTWIRVHNGVRATIVGQARVPSFLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW14</accession>
    <name>A0A7W7WW14_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="481" mass="53107" checksum="09EDF3133D93A741" modified="2021-06-02" version="1">MVAALDRDASVLTPEVRALVAGRHFNPQRRRDKRPSVPYTEGEWQRLQQACRTIIRATFAEHRAALAAAERGRDPRAQGWSFDNLGWLLRRQGPVTWTAFGREHGSAAGKACVELLPKACAALFVDTNAALAYRLLLGTYIGIVPDGIEALGVEDLDWAGDATILLGYLKGRTTQESVTLNRRSVRLLEQWLEHSSPTRNLVAPDARAMLWTRYAPGRYDDVVTVPFTSGQVAEWAERGHQALTAANLALVADDGSPLRLDRRRIRTTFTSLRDRNSWFGSSRSTVDPNHTPAIEGDSYLTATTPAQRDAVETIIENSQADLLRKAQPPMVLSTEATTELAQRFPDAIRAMGLDNATVTELVGTANRDVFVAACADQLSGLHGPVGKPCPARPWVCLLCPLAIFTPRHAVNLLWMQAFFARQWQQLPSAQFMVLFGPYAQRIDTVLAAFRDRDPALLARAARDVADTDAELPLLPEERTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW54</accession>
    <name>A0A7W7WW54_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SdrD_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030635190" description="SdrD_B domain-containing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2062"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="5">
        <location>
            <begin position="1839"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2091" mass="207200" checksum="D7240A21DA729316" modified="2021-06-02" version="1">MLRRVVGGLLAVLLVFTDLAAGSPVARATPVARCGESGTPSVVALQNTHFHVDTSTTPKFLSGYAGYRINAGPAARRRLWLQLGGFTGGVLGLAADQPATLPLPDLAAGANAVRYALLTATGATTAAQSHTITLHDGPPGTGTPVCSRTFTYADVVDTIKALANKVDSVTSTASPTAKLGDAVTVTVNGHTGTLGAGPANDPGVLEYTPTTIGDFPASAWRLERTELRISPDGTAPQVTYVDGLYLSGASGPDRPYTATYTFRAIGPAATAARVRPIQYIASGTQVKHTDAGGTGFGDLPTVSPLAPLTLGKTRTAPADGVLAAGGGTASYAVRVANTGTASAVDAVVDTIPDDAAYVAGSLKIDGRTAADPVVSGRTLTVPGPIPVPAAGATTLTYSLALGATAGVRVNSAVARFGQTVVDTTADVTDSAPATASVTVLGSGALGVTDDSVSTPAGTAVVVNVLANDTSSSGLPLRVTSVSTPASGTAVLDPAGTVTYTPASGASGTRTFTYTATDGYSSRTATVTVAVLPAAITDTYATGKNTQLSGSSVLSNDACTSCTAAVLTAPSSGTVTVASNGTFTYTPASNFSGTATFTYRATDNAGRTADGQVRINVADLAPDYATTPYNTAVVVPVKANDPGCSGGCKPQAGTGAGRGTVTYSSGGTVIVTYTPTTGLWGLDGFTYGITGSSGSATTPATLLVGPPTNSAQTTYGVPVTVPLPAGGSCPNCVYSPGSAPANGSVTVDPATGAAVYTPAAGFAGTDSFTYVVADPASGLRISGTVNTTVGPLAADDSATVLQGQSVSGTVAANDSCPTTCTRTKLSNPSSGSVSFVGDGSYTYTPGSAIGQVSFTYRITSSVSGSAGSDGTVRITVRGAVDDTASTTPGTPVTVPVLTNDPCTTCTLSSVTTPASGTAEIVGGAVKYTPAAGFSGQVRFTYTLTKNSATTTADVVVTVAPIAAGDTATTVEGTPVDVLPLANDLCANCALTGLGTPSSGSVTRVDDVVTFTPAGVGTATFTYSAVDGSGNTFGGTVTVDVVAVPGVQADSATTPSGTPVVIPVLGNDSCGGCAVGIGSDPAHGTVSVDVRSRVVYRAAPGFSGADAFTYSVVDPTTGAYASASVGVTVTPVAVDDSTFTSVGVPVVVDVLANDACTDCVVSVDGSDPRVSLVPGGIRVAPVAGWTGTVTVGYTATDPATDASSSATLVVEVGDARPDSTTVAHGGAVTGLDVLANDDCPGCAVVAVGAASYGTATVRDGLVDWQPPADFAGLATFTYTTSSGAVSSVRILAAPPVLDLDVVVDQPKPVVVPSSATCAGCVVTVVTAADNGDVDGLVYTPRTGFTGTDTFDYLVTDPVSGRAVRGTVAVTVAAPAPRPELTVTATPPDAGVRPVAGQLITWTWTVTNSGNVALTALTPGTGACGASSLAVGASTTCTTSRTLVQSEVDGGSAVGAISVTAGSTAGPATGSGSDTVALARVPGLTVTGTATAPDDAGEGDVITVSYVVANTGNTTLSGVGVTVGGEALSCTATTVLPGASVTCTGTHTATADDVSAGSWSSTGVGSATSPGVAQPLTGQDSTSTPLTAPVPTTTTTPIVTTATTTTTTEPTTPTTTEPTTTTTESTTTTTTTTTTTTEPEPTTTTEVTTTTEPTTTTTTETTTETTSASVTTATTPTTATTTETAEPTTTITTATTPTTTETTEPTSTTVTTTTTTTEEPSTTTAPTPTTPTTEPTTTEPTTTTTTEPTVTTATTPPTTTEPTTTTTEPTTTTTTTTTTTTTEPTTTTGPTTTTTEPTTTTTTTEPTTTTSSTTTTSSSTTVSTTVPTTTTTPESPPVGVVSGTVWFDRNLNGVRDGNEWPLPGVQVTLMTTARAATRADEPPSQITGPDGGYAFTGVTPGDYQVRASITAAGFSYTSDSDGQADWTVDVSVAGGLTSGASFAGIGKGSVSGVIVDSRTGDPIPAAAVKCRWAGFDDVLDTTDDVLMDIVASTAGGFTLEQLPYGHYSCVGTDPATGTTSGVVDVDVVSAAPVDTRFPIVLDQPVTVPPATEPRRAPLAQTGVPAPWLTLLALGLLAFGWGLWFAATRSRRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWD4</accession>
    <name>A0A7W7WWD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="18169" checksum="C0A76EC0DA26072F" modified="2021-06-02" version="1">MSPSTSRPPATDVATDVATDVATDVATDVTEELRALVYELSRRLDEHSRQCVTELGLTLSQANALRDLGTPLTTRELAERMCCEPSNVTFVIDRLEAAGLVRRQPHPHDRRARHLVLTPAGVELRHRLLDQVSRQSPLAHLSGSERDRLRDHLLRALDRAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWR7</accession>
    <name>A0A7W7WWR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031004956" evidence="5">
        <location>
            <begin position="28"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="40"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="345" mass="36441" checksum="70BC1A5D2EFE01E3" modified="2021-06-02" version="1">MKGFTARLTAVCLAVAFAVTPTGTASAADTCALKPRPAGKVLQGYWENWDGAVNGVHPPFGWVPIDDARIARAGYNVINAAFPVIRNDGTVLWEDGMDNTVKVSTPAQMCAAKEQGATILMSIGGAAAGIDLNSSAVADKFVATVVPILKKYNFDGIDIDIETGLTGTGNIKTLSASQSNLIRIIDGVLAQMPAGFGLTMAPETAYVTGGSVVYGSIWGAYLPIIKKYADNGRLWWLNMQYYNGSMYGCSGDSYQAGTVQGFTKQTECLNKGLNIQGTTIQLPYDKQVPGLPAQPGAGGGHMSTSLVGQAYRSIPGLKGLMTWSINWDGSRSFSFGNNVKSLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV4</accession>
    <name>A0A7W7WWV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin component YwqK of YwqJK toxin-antitoxin module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13122" checksum="6CB261D322A02D08" modified="2021-06-02" version="1">MITMRVGFDEVDIQDDLRVTHQGVPFTGEVVEHAPDGRIVALTTYFDGMEDGPYAEWYPTGEPKAAGTVRYGTAVGVHESWHRDGGLAGRDEFDDAGRLLRRLRWAADGTVIDDRDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX09</accession>
    <name>A0A7W7WX09_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP:flavonoid glycosyltransferase YjiC (YdhE family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006326">
        <property type="entry name" value="UDPGT_MGT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01426">
        <property type="entry name" value="MGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="41125" checksum="BE6B1B0E29F83AC7" modified="2021-06-02" version="1">MRMLFTFVGGSGHFRPLVPLAEAVAAAGHVVAFAASPARRAEIEAAGFAAFPVGPESGPPERRPLLVPDREREDHDLREGFVRRMAARNVPEYLELFGRWRPDVVVCEEVDFGGVLAAEKLGLPYANVQVIASGSFIRPEVVGEALGELRAAHGLPADPDLVMRHRHLLLSPFPPSLRDPAFPLPDNAFPIRPPVGATARSDKPTVYFTLGTVFNSESGDLFARVLDGLEDLPVDVIATVGHHVDPAEFGVRRPGVRIERYVPQDEILPRCDLVISHGGSGSVVGTLAHGLPMVLVPLGADQPHNADQCVRLGVAGKLDPVTATPEDVRAVVHEVLTNPDHRRAAERVRAEILGLPEPARAVPLLERLAGPRDHPLSAPDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX91</accession>
    <name>A0A7W7WX91_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030517865" evidence="1">
        <location>
            <begin position="26"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="411" mass="44846" checksum="CF34EAAB818F624A" modified="2021-06-02" version="1">MHRRFPALALVAALAACAPAPPDDTASIPLPGGPGAEYYQRWPHGPNPTGDPFVFPVTVWMQDPVSLDTGTPDGRAYRDIGVPATLGLWDDERWHERQAGLYATGWKAYVSAGKVDAVLADPGRAAHYLGYLVADEPDMQKSAGHRYHPELQPSAVLRRADEVRAQDPTRPTFVNFGMWMGTPDGRHDYAYVEETYEQDMRTYCQAADIASADFYGWTHPDPDKVGAFRYGQVVDTMRKWCGTGKPVYGFVETGHPYEGGGLITADQVESAVWNAIVHGADGINYFAHSFYPEGDDDFVSALTRPEIAARLKDVNARLQRLAPVLNAGGGAAFTMRGDGDVPITVRLEKGHVLAQADGTPARPDSGRTRAAIPVPVTEGTAEVVDENRTVPITGGRIVDDFAPYGFHVYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXF7</accession>
    <name>A0A7W7WXF7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10984" checksum="97F35B81F4D33B4A" modified="2021-06-02" version="1">MTGFGTSADNLDEHADYIEDVLAPDVREAVEAAGRVKLGDDSMGLLCQVYSFVFDEELDTARDLLRKLPDALDATAGDLHATATGYRTVDSGESTNLDGMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYC8</accession>
    <name>A0A7W7WYC8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13217" checksum="5F0AA8E638002EC3" modified="2021-06-02" version="1">MSPKKGDPVAPPAIGDEWRIRYCTTEAIKGWQDLETRASGNLRQAWDTMREDPGPGPGKPTNRHHQLKGSLAHGTHNGKTLPRWQIEVTGGDRIWYLLDADKHTVWVQYAGAHPKATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYK4</accession>
    <name>A0A7W7WYK4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1601" mass="172503" checksum="948C251A9EBE4744" modified="2021-06-02" version="1">MVELAALAGEVAGQLRCAADAVESGVTPPDPLADRLDDYLERRRSTLSAVAFETGREVPADFSGAHAEISSERNRRTDLERAARDSAVVRLRGEVADLDRMIGTATPAVRDHLRAARDAALDRLTELGVQTEAKATTGPLTDDGTRAPAATGPTDAAAPGTGAPEALPATAGNLDAEPEAEPTAIRPAEPEPVTHHENADDLAFPWEVGDPPAVVRLVRTGALAEAYWLTSCSGEPDRRTAALKFATDAFSHQDGTAVLTTLGLAPDDLVDDHDAATLVLVALLRAGLVAGWGHQTSGRLRPAVTLPAAWAELLDAAVDATRRGVRVDPVLGMKGVAVDGDAVRAEIGAKARTLLAELPRRKTIYQRASKVLRWFLRTDQPLHGALVAVTGWAAGEVDAATLSAALAAVADRDALIDAADLATRAPKQRDAIIADARRMLVRNIDEVVAVVTEALLVDDRLGVDGRTSEAEASLSKAFQAVADVPVPDGVAGAAVALLRRWLDRPAAVPAGPPDADVLLLLPDLPRTTDGRPDADDPRTLPLLATLAGPLDHAAAGTAYFERGDLRRAARLLDLLDARGERVDHLRTGLEHWTEVWTGRHAAAVRAAADLLARVRTQNLLEADERLVNNRLHGLGTVSDGRFDVARADLAELTDELRRREHRRTEALRAEVRRAELSDADRTRITGLLDEGDCVTATEFVAFARAGRPLPDHLPEAVGDLQNFVSLLGKGAEEGLPRPESAKTWARLAVGDNGLLTSAETALDAWDSLSVGRNFSADRFQGSVRTVLRLLGLVCEGGTKERGPRGGVRTVRVRAHPNDGSYVAELGSAATEYTVVVLTEESRGRSVLDGLDALTSGRANVVLCLHPLDLAARRALAARARRGTPHAIVIDASVVGYVAATAPGSWRTTQRITLPWAAFNPYQPFVAGLVPPEVFVGREEELSEVVDPNGGLFVYGGRQLGKSALLHRARKDFDDGEAHHAIYLDLKGRGVGESEPAARIWRELTIELKARGVLGQRVSNDAGASVVVDQVRAWLRVNPARRILLLADEADAFLTADSRATTQSGGIAYFPNVLRLKDLMESTDRRFKVVFAGLHQVQRFRELPNVPVAHGGPDIPIGPLRPADARRLVVEPMAALGYQFERPELVWRLLAATNYQASLVQIFCEELVRTLQSRGLAPTTPPTYVTEADVDGVAASDLVRGRIAERLRITINLEDRYRVLALVIACRSVDDAFAVAYPADELLRGARETWPAGFDRMTVSEVGVYLDEMVGLGLLIRLTDPVRYAVRSPNVVTMLGTRAELERELAEMDFDMPYEYNPRAARRLLEEHQGAELRSPLTDGRLAAVTTAHHLAVITGTRALGVDRVPQAVRDYAEVRGSTVTKVAPAGVVGALTTISRRTEPSVLVTDVTGIDRVEAEQVVRRLVKQVAVQNLAVVVLAPPELATGLAELAGAEPEHPRRWTVDTIRSWPECPFDVPRARQALIDATGGWPELVEDVVLRVRRGAAQAQALAQWVKRTAQPEQARRLLAERGVDAALVRRLGDWHRYVEPGDRLFPADIAVAVGVDLDTVNALVDDLDLIGLLDTGPDGIALDRVVHRCLLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYW4</accession>
    <name>A0A7W7WYW4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="39" mass="4244" checksum="6F1DB474BD390CD2" modified="2021-06-02" version="1">MALPCPADTIRWQGGEAVAAADRRAQPTLAGRPRDRPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ55</accession>
    <name>A0A7W7WZ55_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15643" checksum="C0661046C37DD456" modified="2021-06-02" version="1">MIREGTSALPAQRAAGADEDRVGAVERYKEIIGLAGEAVERMRTADRARVADLVGRLIETQELMARAIAQERDVRVGVSVVWEQAVEALWNERWFAITPVPPPNEKVPARPQNDYVQAMDAAYRNLVESLQKRSLFGRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA7</accession>
    <name>A0A7W7WZA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribose pyrophosphatase YjhB (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16802" checksum="14C9CFB93B16BC3E" modified="2021-06-02" version="1">MTDKLRKMRVAAYAVIIDEGRILLSRWLGPDKPMWILPGGGVDHGEDPYDAVVREVFEETGYRAAVDALLGIQSLHGPLNRDGVDLDYHRLRILYEAHVTGGELTFEVGGSTDQAAWFPLDKIPEDHVESVDVALELHRLRPADGRAPSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZQ4</accession>
    <name>A0A7W7WZQ4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8700" checksum="A740B8FF370BD918" modified="2021-06-02" version="1">MTDNTTSATNPPDAVHRLDALVVEAALRGRRPFRELPAPEAAEVLRILARRGDRLGRVAALLDVELHLIAEQYAAASGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZY6</accession>
    <name>A0A7W7WZY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="23144" checksum="B55B0C4732C68F99" modified="2021-06-02" version="1">MSVSVMVVDDHPLWRDGVARDLAERGFDVVATAGDAASAVRIARAVRPDVVLMDLNLGEQTGVEATTMITGSLSRTRVLVLSASGEHSDVLEAVKAGASGYLVKSASAEELVEAVNRTAAGDAVFTAGLAGLVLGEYRRMAATPDEDKPQLTDRETEVLRLVAKGLTARQIATRLVISHRTVENHVQSTLRKLQLHNRVELARYAIEHGLDVEPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X043</accession>
    <name>A0A7W7X043_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (Sigma-E family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="172" mass="19341" checksum="394EA72A6775E46A" modified="2021-06-02" version="1">MDQRDEQEFAEYFVARREAVRRTAFLLCGDWHRADDLAQTAFVALHRRWRKVRDKGALDAYVRRTLVRAVIDESRRPWRRERFVDEVPDVPADDGALADAVVTREALVAGLRRVPPRQRAVLVLRFLEGLDVAGVAVALNCSEGTVKSQTSRGLAALREALGDSLDDLKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXQ4</accession>
    <name>A0A7W7SXQ4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">F4559_000249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4962890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="272" mass="30134" checksum="5FF6A8B51D355847" modified="2021-06-02" version="1">MGQKINPHGFRLGITTDWKSRWYADKQYAEYVAEDVKIRKLLSRGMERAGISKVEIERTRDRVRVDIHTARPGIVIGRRGAEADRIRGELEKLTKKQVQLNILEVKSPESDAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRSPQVKGIRVQCGGRLGGAEMSRSEHYRDGRVPLHTLRADIDYGFFEARTTFGRIGVKVWIYKGDIVGGLSAKRERDAAPAADRAPRRDRGDRPNRARRSGASGTTATSTEAGRAAADAQADAPAAEKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXX5</accession>
    <name>A0A7W7SXX5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplO</name>
        <name evidence="8" type="ORF">F4559_000262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15771" checksum="B9DC05A8E47D546F" modified="2021-06-02" version="1">MTIKIHDLRPAPGAKRAKIRVGRGEGSKGKTAGRGTKGTGARKNVSPRFEGGQMPLHMRLPKLKGFRNPFRTEYQVVNVSDIARVFPEGGRVDVDALVDAGLVRKNELVKVLGDGDLDGVKLDVVAHKFSRSAVEKITAASGTTTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXY4</accession>
    <name>A0A7W7SXY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="31691" checksum="5BAD0F1E6DF27E94" modified="2021-06-02" version="1">MSNDDKRRRLDGSTDRLSVADLIARREAETQPIPRIEDDEPGTVRIASPRTDLPGRELPGRELPGRELPGRGLSGRELHVTELLRREGRAGEEERGGGMSVPKLVALASGGVVLCGTVAFAASQWLSSPDERPAAEVRYDTRPAARGTNTIGNDLAAEVRQSTTTEETTAETTTGTTVEDQPRQTVDRPRSQQPQPTTTQPPTTGTPTTTTPGSTTAPTTTTPTTTDPPANPTTTASSTPASAPDAPTGGPSSAPSTEPSVPSAAPSSEPSSAPSAEPSATPLIPTSVLGVSLDPIGAFDFFAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXZ7</accession>
    <name>A0A7W7SXZ7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="8" type="ORF">F4559_000292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="215" mass="23066" checksum="91AED0429BFA1DAE" modified="2021-06-02" version="1">MTEQQTEDTDVTTPEAAEFDEAVEAVEAGTAVEAEAVVEADADAEAVVEADAVEADAADEADDAAVEGDAEEESAAAPVVRHQLNGAHHLAQTVGRRKEAIVRVRLLPGTGKFTLNGKSLEAYFPNKVHQQLIREPLVTTEKPETFDVVANLRGGGTTGQAGALRLAIARALIAVDSEDRPVLKKAGFLTRDPRVKERKKYGLKKARKAPQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY00</accession>
    <name>A0A7W7SY00_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="114" mass="12216" checksum="070D5318A59577BE" modified="2021-06-02" version="1">MEFVRLLLVFLHLLGMGMLVAMFFVQKRAGADAPLNKGWLHGAALQLLTGVALVGLAPLTDKDYDHFKIGVKLLVLVVIAGLVATNLNKKPASWLTPALAGLVVVNVGVAVFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY93</accession>
    <name>A0A7W7SY93_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15245" checksum="1288BC10179BADA2" modified="2021-06-02" version="1">MSFTAYWGIHDGSIDNGEIRTITTDAEVDALVTELTKEISGFARIHHEGRPTMPVPFTGEPGPDHIVHAGVHRAYGYLGHLDPDHDFGHPVGDPASPVYHSDSEEFPAGSGIPVETLATALKEFLATGQRPTCVDWTPAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYD8</accession>
    <name>A0A7W7SYD8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
            <ecNumber evidence="6">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="168"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="39994" checksum="24E753A7789589E1" modified="2021-06-02" version="1">MTALNDPMTAGLTDDEIFRAHEGGKLGVDVTASLADPRALSIAYTPGVARVSRAIADDASLAARYTWAHRLVAVVSDGTAVLGLGDIGASASLPVMEGKAALFKTFGGLDSIPLVLDTTDVDEIVETLVRLRPSFGAVNLEDVAAPRCFELEARLIEALDVPVMHDDQHGTAVVVLAALRGANTVLGKKAADQRVVISGAGAAGVACAKILLAAGVGEVTVVDSRGIVHAGRDGLNPVKAQLAEVTNGSGLRGGIAEALRGADVFVGVSSATVPEELIASMADDAIVFALSNPDPEVHPDVARKHAAIVATGRSDFPNQINNVLAFPGIFRGALDAGARRITEGMKLAAADAIAAVAADDLAADRIVPSALDPRVGPEVAAAVALAAREDGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYE4</accession>
    <name>A0A7W7SYE4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GT2 family glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1019" mass="104517" checksum="D70D97A5E643D4CE" modified="2021-06-02" version="1">MTAPVLAVVVCHDGEQWLGTALSALRRQRTAPRYVVAVDTGSVDGTAMLLSRATDGLVDRVLTLPRGTGFAEAVHAALDAAPGPVEWLWVLHDDCAPEPECLTGLLAVASAVPRAAVLGPLSLDWADPELVVEAGVSTDASGHRQTGLGGAEPVAAFERITEALAVPSAGSLILRSAWDRVGGYDRRLPLLREDVDFGWRVNRDGGLVLCVPTARMRHARAATRGVRRLDAVAARPGPSPRGVDRAHGLRTFLVNCGTASFVLGIPRVFLLVLLRALGFLALRRFGDAHAEVGALRYLASGRAGLVAARACRPAKGVVPGLFTSRFTRLRNAFRGFVGYLVRRRVEADAALGRLPPATRPVWTLPSEVEGPPVRLPGGLRHVAATVRVDRPSPVPRFVGVDRWRVLRSVVFGPPCALVVGLVAFALVAHAGRFGLDLAGGRVLPVPDGLWEQYLATWHPVSGGTMAPAPAASAVLAAAGVLTGGPAALVSLLFLFDAPLAGLAAYAATRRAPVRRPVRALVAAAYAVLPGAVVAVAEGRLDVVVVHLSVPVVFAGLAAVLRGGSSWLPVASGTSLVLACLGAFAPLLHAFAVVAALVGFVVVPGPGNGVRRRVVGLFMVVLLPVALLLPWPAAVVGNPSILLHGVGAVVPTPAPSVGELAVLSPGGGSVVGVLVVVFALVLALVRPSVAMVPGVVVAVVAVGAVWLVRTVAVVPPAGGPAFAGFVGGPLLVVGWGLLGVVLAAFRQDARPVPAVRVVAVAGALSVLGLAGSGVAGLAASVLTSTTVPEFATGRSVLVLGTPTRQVVGRLPAFGDDDLVPTLSSPGRLARWHRALTEGSVPEARSALAAASAAGVGYVVVADRAVERRVRERVGELVAPSGLLPDGRPVLRVQLAGGTAVVLSPDLARQARTGASPPASLDVAGLTPVEAAAPYAAVRVSEGAPGRLVVIAAEEEPGWRVTVDGRVVAPTRAWGHLVAVPVPPAGAEVRVEASPTLRSWLLLVQAAATLFTLATALPTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYW6</accession>
    <name>A0A7W7SYW6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="118"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="744" mass="81577" checksum="2AAE4E9FDA9F3D3C" modified="2021-06-02" version="1">MGGRADDGTTRKPNPEIAELLRSLRGRMTLQALAERSHYSISHISNVERGWKVATENYLRTMDGVLDAGGRLLALLDDTTRPDTTRHRPSQLPPAPHVVGRDELLHNLDRFLDSHSTRTSAQVVALDGTAGVGKTAVAVAWAHHIAHRFTDGVLYLDMHGHSPNPKPVDAEQALFDLLQVLGTPQSSMPVGLDARSALLRTLLDGTRTLLVVDNVARTEQIRPLIPASTHCLVLTTSRQRLPGLTVHHDAHCVTVPPLDEPDAVNLIAEIAGADRVHAEPDAAVRIAHSCSSLPLAIRVAAERVAASRHLTLTALAAELSDDTRRLSVLSVGEPADAVRSVFSWSYDRLDASAARLFRLLSLHPGHEFGIDATAALTALSPADAEFGVDALVRAHLLVETAYRRYGFHDLLRAYAAERATTDEPEATSAQRRLLDWYLDSATTACTTLHPKNHDTPTMSRTEALDWLESEMDNLAAATACASRTGHNRVAFGLPKVLVDHLYWRNPWTTWFDALTTALHEARRVGNQDAAGWILRNLGNAYFASNRPGDARRRYAEALESHEDTGNLDEQKWCRIGLGKCASRTGDHTMADLHFATAQRLCEQTGDDKTKATATAYRGDVQRALGNHNAALTLLHQALDTFTTTNDTDSIVCTWAHIAAIHHDKGDLTTALARLQQAHTASLTAANPWTQADILHRLGELRLKTHDHPGCHEAWTQAIALFDHLDDPRAATIRTQLAALTEYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZA4</accession>
    <name>A0A7W7SZA4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="36722" checksum="F4758777891DD31C" modified="2021-06-02" version="1">MTSFRSLSVAILKGLVRDRTALFFTFLFPLMFLVVFGLIFSSGGASKTKIAVAGDGPVVTALGDTGVLELLRTDAASARRQVDDGDVPAAVLVDGDDVRVFYAASDQVKGQTVVGVVASVVDRANVAATGQPPRFTLDVASVEDASLKPIQYLTPGILSWAVSISGVIGAALTLVSWRRKQVLRRIRLAPVSPFTVLSSRLLISVGTALAQGVLFVGIASTKPFGLVLSGQWWLAIPLLMLGSVAFFSIGMFVGSFSKTEEAANGVANIIVMPMAFLSGSFFPLDDAPGWLKAVSAVFPLRHMNDGMLDVLVRGKGIEALLVPASVLIGFTLVMSFLAVRLFRWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG7</accession>
    <name>A0A7W7SZG7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8410" checksum="CEB4199B08B70497" modified="2021-06-02" version="1">MANLVTLCGSATTKCHGEVESGQRALATAEGWVVPSGIRLEDWPVLRFRETWSLPGEHGWDDDVDPHPLQTDPRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZJ3</accession>
    <name>A0A7W7SZJ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7064" checksum="83BA419ED1E62FC5" modified="2021-06-02" version="1">MTTPTPHATTALITTTDDVYNLHAEIASILDRRLATITTRTRTDIADDLDAAGYTEAAAYLRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T033</accession>
    <name>A0A7W7T033_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33595" checksum="158427C01D5C1D4F" modified="2021-06-02" version="1">MTKTWHRPTLWLAAVMAVLALGTAIGLLVDDRVLQGSPLWLKPFKFSVSLAIYSVTLSWMLSLPHRGRRITTALATLVVGIMAVEIAFIVASTWHGAFTHFNQSEDALNNALQFAFGFVMVMFAANIVLALVFTFQRAVDRPTMWAVRTGTWLAIAGMGIAYLMIFQFDQGTMATDAAGRTVELSSGHSVGVPDGGPGMPITGWSTMGGDLRVPHFVGLHGLQVMVLLLFGLTALKLTDRAKLRLVFIAAASYAGFLALLTWQALRGEPLVHPGFTTLAVAAGIAVATAAATVRVVKTGKAVPLPDRRPALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T071</accession>
    <name>A0A7W7T071_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6587" checksum="76F1372A43ED37E9" modified="2021-06-02" version="1">MQQEWRKSTHSSGGGPECVEIALAGTGAAVRDSKNRAGGQLAFGTAEWSRFLGTVKHSVLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T098</accession>
    <name>A0A7W7T098_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="11" type="ORF">F4559_001572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="9">
        <location>
            <begin position="35"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="10">
        <location>
            <begin position="310"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="41482" checksum="D2B78F8D7E6E8F4D" modified="2021-06-02" version="1">MDRVILRTGKPTDPVGATAVPATREDPVDSRRTPLHAEHEALGAHFTDFAGWRMPLRYDSELAEHHAVRTTAGLFDLTHMGEITLTGPQAGAALDHALVGHSSAIGVGRARYTMICRADGGVLDDLIVYRLGDLEYLVVANASNVAVVHEALVERAKGFDVEVADRSTDYALLAVQGPASVRVLAGLTDTDLDTVKYYASYPSTVAGRSVLLARTGYTGEDGFELFVAPDDAPHVWRALLEAGKAHDLKPAGLGCRDTLRLEAGMPLYGNELGTGRTPFHANLGRVVKLDKPGDFVGREALADVEADTTLVGLKTASRRAPRHGYPVVDASGAVVGEVTSGALSPTLGYSIAMAYVAKEHATPGTGLAVDVRGRREPVEVVALPFYKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R4</accession>
    <name>A0A7W7T0R4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TM2 domain-containing membrane protein YozV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="7">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21529" checksum="1C523A3C93BC778F" modified="2021-06-02" version="1">MSEAERIRIGNQQREEAITSLNDHFAAGRLDIGEYEVRVGQAAEAQYAEQLAGLFTDLPHPRPDFLPPPTYAGPPPMDVPPPPPPFAQPQTGTYYPPPPAGFPPTGPYYAAPSPYGPHGHPAPYGYDQFTGQPLSNRSKVVAGLLQIFLSFGIGRFYTGHYGIAIAQLLTCGGLGVWTLVDGIILLVSGGTDPYGRKLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T125</accession>
    <name>A0A7W7T125_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="32369" checksum="5694E733A389D581" modified="2021-06-02" version="1">MSTNGVHTDPHAVADLAEAAEHEHGAVAPDGSIVGYKAGRTLPLRVELARQLRRRRTQLLLGFLVLLPVILVVAFELGESSPNRRAGGFVDLATAGGVNFVVLTLFVSAGFLLPMIVALFFGDTIASEASWSSLKYLLAAPVPRHRLLRQKALASGLLSLLALVLLPTVALAVGVVWYGAGEVVSPTGEAAPFGQGVAGVALSVVYIAIQLFWVAGLALFLSVSTDAPLGAVGGAVLAAILSQILDQITALEDLRNYLPTHYSLAWADLLSTDIDWSQPAKGVFSSLAYGAFFTLLAARGFARKDITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T126</accession>
    <name>A0A7W7T126_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21523" checksum="2DFDD3ACA7621739" modified="2021-06-02" version="1">MIAATTRLPGIEVVPETDALLWTRGDRASFAVLFDRHAEAVWNHAYRLTASWSLAEDLTSATFLAAWHRRSDITLVHDSALPWLYTVAGNLARTEFRRVGRFRRAVLRLPLPDAVPDHAEGVASSVDGGRRLSRVLAVVRTMPKAEREAVELCLLGELSTAAAAEVLGIAEVTVRSRISRARSRLRDELTEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T199</accession>
    <name>A0A7W7T199_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_001571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10595" checksum="709A7B63DB4E64DA" modified="2021-06-02" version="1">MSGALSRFRVMAYVVGVGLLGLVFAMLVKYLGDNPGMMAVVGPVHGFLYAVYLVAAVDLALKGRWSLKGTALVLVAGTIPFVSFYAERKVVDSVRAGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1I7</accession>
    <name>A0A7W7T1I7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="97"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="450" mass="47600" checksum="D3345B4D162736DE" modified="2021-06-02" version="1">MPRRLPPPPALFTARRHELARLDAWLATDRTPLVVLTGPGGIGKSALAAQWLDGVRDRFPDAALHTDLGDPASDPVEDFLRASGVPAHRMPDDPVLLYRALVARRRVAVLLDDAKSAEQVRPLLPDAGVAVVTSRSPLGLDGARVVEVPPLGPDSSLELLERLVGSRVVAERPAAEELVRRCGGSPLALGIVGARLAAGSARTLAAELCALRAEGVAVDPTDAGTTEPLFDLVRSGLPARHARALRLCALLPGPSFDAVGAAVATGEPECRVAALLADLTEWNLLTDAPDGRHRYHALVRAQARQVRVAEHEAARRRIAEWYVVLGRSAPAGELRAAARMAIRSGWPDLVWRLGEALAGRCRADARVPVLEAAADAARRADDRAAQARLTVALADARTRSGRFAAAVRAATEAVLLADRAGDTVTVARAMRRVGRIAVAARRASGHPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1J9</accession>
    <name>A0A7W7T1J9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031506232" evidence="2">
        <location>
            <begin position="25"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_4" evidence="3">
        <location>
            <begin position="375"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="51599" checksum="FC53C38C2ACAB302" modified="2021-06-02" version="1">MRKTITVLSTAALVAAFLPAPAHAAGFGIQQLVWAPCTDIPDPGALECATFDVPRDWNRPDDGKRFTISVSRLKPKGPGKGVLFTNPGGPGDLGRELPLELTHRARLVDNLEIVGIDVRGTSPAHGISCGGHDFADHPDPRDRSPRGIRAVHDKARDHARLCRQRSGEAGRYITTEQTVKDLDLLRRLMKVDKVDWLGYSGGTWLGAYYTAYFPRSVGRFVLDSTFDVTGTFQGGFAEIPRATERRFRADLLPWIARNDATYHLGTTPEQVRGRYETTRASLAADPVELPDGTLFTAMSLDRALTAATRHKEAFPQAAAVLAGEFAAFDPGSPDASRATAYMIMCNDTPFRGGPDFLAEESARLGGRYPLNGYYQPLAPCAFWDRPSLTLKTPTGQGVPPVLFVQTERDPATPVEGARRTHARFAGSRMLTVDDGDHTVYGYDNACVNDAVEDFLVDGTLPTRDTTCPGTPIGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T2</accession>
    <name>A0A7W7T1T2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="115" mass="12587" checksum="4E296BAB9A002DC2" modified="2021-06-02" version="1">MMTETIARRAGDYLGDGGRYLIWEILDGRGVAAELYVFVDTHEIANIETRSDRRGEGLARALYRAADTQVGVFHAPAGHRTEEGDAFARAVGGPVADYPCDCFACDTIDDEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U0</accession>
    <name>A0A7W7T1U0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pup--protein ligase</fullName>
            <ecNumber evidence="2">6.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proteasome accessory factor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pup-conjugating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pafA</name>
        <name evidence="4" type="ORF">F4559_002348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N(6)-([prokaryotic ubiquitin-like protein]-gamma-L-glutamyl)-[protein]-L-lysine.</text>
            <dbReference type="EC" id="6.3.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein degradation; proteasomal Pup-dependent pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein pupylation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00997"/>
    <dbReference type="UniPathway" id="UPA00998"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070490">
        <property type="term" value="P:protein pupylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02111">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022279">
        <property type="entry name" value="Pup_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03686">
        <property type="entry name" value="pupylate_PafA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="439" mass="49655" checksum="3A88EF598DABC140" modified="2021-06-02" version="1">MTCTFHGQRRLSPDEVARYLFRRVVSWGRSSNVFLRNGSRLYLDVGSHPEYATAECDDLAQLVTHDKAGERILEDLLVDAERRLADEGIGGDIFLFKNNTDSAGNSYGCHENYLVARAGEFSRIADVLLPFLVTRQLICGAGKVLQTPRGAVYCLSQRAEHIWEGVSSATTRSRPIINTRDEPHADAERYRRLHVIVGDSNMSEVTTLLKVGSANLVLEMIEQGVQFRDFSLDNPIRAIREISHDLTGRRTVRLAGGKEASALDIQREYYERAVEHVAKRTPDPMADRVLELWGRTLDAVAAEDLSKIDREIDWAIKHRLIERYQAKHDMDLSNPRIAQLDLAYHDIRRGRGIFDLLQRKGQVDRVTDDGEIEAAKDTPPQTTRAKLRGDFIAAAQAAGRDFTVDWVHLKLNDQAQRTVLCKDPFRAVDERVERLISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2B8</accession>
    <name>A0A7W7T2B8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20979" checksum="95EA3336C47C41C7" modified="2021-06-02" version="1">MTDLRRRNRERARERIVAAAFALFAERGFADVTVADIAERAEVGRTTFFRHFGDKQEVAFSNEHAMSALWGGWLDELPPLTTLAEALAEMRRIAVAMCRTYTADAAHYLAHQRLLRDNPELLDRSNRKFDRMAQAARHSLERRGAEPEVAALAAHTAFACYRAGLDLAGGDPAALPAAVDAAFARLAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C1</accession>
    <name>A0A7W7T2C1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-binding_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="25769" checksum="758B62DD6422F3DD" modified="2021-06-02" version="1">MGYEDVESELRRHPKVSQCAVTKIRTGHRKDTLVAYVVTTGRVHPSEIKAFLSGARVRPSRVPQSVIPVDSLPRTREGAVDRDGLPLPVVPARSRGTKGPSDEPVSVAFPALTLVFGVAAFVLTDRFWPGSTDLSLVPQPWAGLFTGLYVAESLAFGLGIAVLFLGRERLSDPHRPGLTTAAHLSVVWLLAAWWPQDNFYRLAAKNDWATQAVLVYGFNVSLMIAAAIVVLFVTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E2</accession>
    <name>A0A7W7T2E2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">F4559_001454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="34491" checksum="67DD72E6C142D0A9" modified="2021-06-02" version="1">MGERARHVPVLLDRVLDLLAPAIEDRDAVFVDCTLGLGGHSEAVLHRFPQVKLVGLDRDPQAIGLARERLTPFADRVEFVQTTYDRIADVVVGTKVDGILMDLGVSSLQLDAEERGFAYSKDAPLDMRMSAGTGETAADVLNTYEVDDLTRVLRDYGEERFARKIAGAVARERAREPFTTSGRLVQLLYDVVPAATRRTGGHPAKRTFQALRIEVNRELESLRLALPAALSVLAVGGRIVVESYQSLEDRMVKRAFADLAVSRTPPGLPVELPGHGPELKLVTRGGEPAGELEIEDNPRAASVRLRAAERIREAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E8</accession>
    <name>A0A7W7T2E8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="7928" checksum="0EECEF67C97F9708" modified="2021-06-02" version="1">MITSIAEQTSLLLLNASIEAARAAGRTDARPAPGTEDVAAVVARVKAVHPVMAMAIDEQFENAAEKSADKSDHPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X3</accession>
    <name>A0A7W7T2X3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prenyltransferase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002953</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="PTHR11774"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="582" mass="62316" checksum="79FF7C10DF555751" modified="2021-06-02" version="1">MTAVDTTPRAPGGLAVSGGEADLWCTYAATRTLAWLGRVGDAPGVAETAAFLAGKQNADGGYAWSKGMASDAWATFYCAQALADLGADVPRLERTARWLRGTWTGDAYAMMPGQAADVWATHFSVRTVVELCRADVPDRRRLLDWLRLLQTPDGGLGWSPEHARYGRSDVRACFYGVMAWRALRTAEPDLAPPWDVPALLWWLRDQQGPDGGFRFGADARTPCMWATYRATAALDALGAGPRDRAGCLRWIEDRRTADGAFVRWAGYDVADVWASFCAVGSLRALGADTGVHADPVVARVRELACPDGGFTYREPEHAGDALSTAAAVLGAEPDDPRRAPWRQWLAGCRLPNEGGVMYMPARGSEVRCTLWALAAGACADDPAARGEIADWLRTLQNTDGGFGYWEGRASDLVSTSAAVEILRLLDIPVARALDTRRLVGFVEACRSTVDSAGFGHVPGSTPTLRAGLQAQRVLDGLGRGVRRDVVTLLDRHRVAGGGFANEGARMPDLLSGYEAVATADRFDVEVDTGHLATFLDRVRTPTGTAWTPLAPVGGGPLADCLARLLRRRAAGGPTDLPALTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Z9</accession>
    <name>A0A7W7T2Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative MFS family arabinose efflux permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="416" mass="42694" checksum="143F5E8A957E6C81" modified="2021-06-02" version="1">MTPPPAALERYLAARLLSVTGGLVSLVALPVLVYRLTGSAGWTSAVAMAEALPYLLFGLVAGALADRVDRRTLMVGADLVVAVALLTLPLAWWLDVLTAPHVVAVAFAAQTAFVFFDAANFGALPTLVGRDRITDAYAKLFGRTTLAELVVPPAAGLLVAVVAPAGLIAVNAVTALGSALLIRGVAGALSGPRPAQASLIRDIGGGLRFVWGHPVIRTLTLVGALPSAAAGAYVAVLVPWADQVLHVSAGGDLRLAVLFSCWGVGALLSSRLVPTLTRRWGGARLALGALPVSLACALLTVGTTQWVVAGLAAAAWGAAHSTVVINAVTYRQRLCPEDMQSRVNTTARMVSWGLGQPAGAALAGTVAVAAGPRVGLAAGVGVLLVGVVLAWATPTLRRAAREQDHQTQDHLQRNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T363</accession>
    <name>A0A7W7T363_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="212" mass="22710" checksum="F6BE89E6796BFE7A" modified="2021-06-02" version="1">MITVLVADDQAAVRDALRTVLSAEPDIEVVGEAADGAAAIVESDRLRPDVAVVDLRMPRVDGIAAIHALTGRTRVLALTTFDLDDYLFGALRAGASGFLLKDSDPDLLIAAVHAVHRGHGLVDPRVTGRLIGRFARLSPLPPSPELDLLTDREHEVLRHVARGLGNAAIARALSIGEGTVKTHVARILAKLDVPGRVQLVIYAYEHGLVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3A7</accession>
    <name>A0A7W7T3A7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003142</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030926412" evidence="7">
        <location>
            <begin position="41"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="266"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="713"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4965783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="807" mass="82877" checksum="AC39A4C0B389BBA7" modified="2021-06-02" version="1">MLSIARDTLKARWTSLVATFIGLAVGVAVLSSMAVVFASALAPQSPAPSRYAEAAVVVRSPETRTVDDGAVLDNAEPEPLTKEVLAAVPGVHDRSFYAQVADRPAAAPYGRPWSAAKFAGYRLESGKAPALADEVVVAASTGAKAGDRVTVLTASGPRPYAVSGVTADVDFETAVFFTDTEAARLSPDVIAVVADGSAEQVRQAVGDRADVLTGDARVKAEPGSSRNRGALLGIVSMTATSIGVAVSVVAFVVAATFAFSITQRTREFGLLRAVGATARQVRRMVFAEALLVSVSASLLGCGLGFAGAPALASALKSAKVGPKWYELTVWVVPMLSAFVLGVGVALLAVWSAARKAGGTSPVEVLREATADTKAIGRGRLVVGLSTVVFGALVVLFVVAKASWLSMVPVLYTPIAAVPLIGVALLTPVVVKPLARLLTWPLGRSKGATGMLVRASIVTAVRRTATTAGPVLLLVGLSVTMLGVTYTVGSAEVNAERATVTADHVVTPAGTPGLNEAALARLRGIAGVTVAPITPLRVNHRKFDDDPEINDMRAVAVDPATVGSTLKPVVAEGSTADFGDDTMMVDENVRLPLGVTVAVWFPDGSRAELKVVALLRNSETYISSKHASGVLPTRAYLTTPPGTSTEAVNAAVAGLGARAVPADDYFVVADPFQSPSLRFGVILGLGIIAAYAAMSIVNTSILGHADRRGATTALRLTGATSKQVVRVAAYEAVIVAAVGIVAAVVISAVSLFGLRLAVSQEVGPMPVILPWWALIGVVLGCVVVTVASAVLPTRLALRSPPATADPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E5</accession>
    <name>A0A7W7T3E5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding CsgD family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="747"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="815" mass="85401" checksum="C9A684CF93818D0E" modified="2021-06-02" version="1">MSHSHGREREWTSVLRLLSAPGGVLTLDGPPCSGKTRLLHDAVDAARDRGLPVVLVGGDHLAASADVAAVLDSRALVAVDQAHVDPAALLDLLDRVHGRPVAVLLTLTLPLAGAEVRRAVSTQGDVVSLGPVDAAAVRRLVVDLLGVPPGPDLLALVATAGGNPRLVADLVTGLREEGQLEVDATGARLRGGWLPRRVGTLVRARCDRLSARANQVLRVAAVLGRTFPLHDVATLMGETAAALLPAVDEVLASGLVESVDDRLEFSCDLVWRAVVESIPESVARALRHDAAVLRPAQPPVAVTGERGQAAVDGVRALAANGRLGSAIALARAGLSGRLPGPEAAELHVVLGGILLADGRPADAVAEMEHALAEGDVPEPVRRLASAGRLLALYFAAGDPAGAHALSVLTVRDREASDADVVMAATVHSCLEWTAGNLAEAMYWGRESTRWDLDGPTAWWQSHAAVAYALKLAALGEFDAAERLVRGDGPDTDSAVRSGAPAARLVARARVLTQAGDLVRADEAARAGLALARDRGLRLLVPLASTVLATVALHRGDLTGAAEHVRCYRGDLAAGEALLHSGQYDWVELLLTHARGGPGAAAESARALLDDPDGARRMLVEEPGAAAWLVRVALDVGDSALAEVAAHTAEDLAAANPGFGRLGAAAGHARALLDRDVDGLRSVVDRHRHPWASAHANGDVARLLAELGREDRAHGYRERAARIFERMGAEAELARLPGAAPPADSGTESADWRRLSEPERDIARLVGAGLTNRQVGKQLFLSPHTVNYHLRGIFRKLGISSRVELARLAHSQESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M7</accession>
    <name>A0A7W7T3M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043758">
        <property type="entry name" value="DUF5703"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18963">
        <property type="entry name" value="DUF5703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7984" checksum="3E1B6995BE1330D9" modified="2021-06-02" version="1">MTEEVVDGDWEYRPLRLPAGISRRTATTQLAIHAEFSGWELSRTLLFGDGSRKVWLRRRRTALGMPGPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T403</accession>
    <name>A0A7W7T403_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="22807" checksum="5F7A788D78F37BBB" modified="2021-06-02" version="1">MIESTLVSVDVLALRFDTGARAVLLGISERPQEPFAGALALPGVLLRRGERLRDAAVRAAADKLGVKVRATGQLITFDEPSRDPRGPTLSVALWAAVDPSAAGRTWVPLDDVPHLAFDHDRIVADCRPLLRDRLWRDPAFTAGLLGTEFTTAQALDLTEALTGERPYPANLGRTMERVPGLRRTTQHAASLPKGGRPPSVWRWEQPAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T417</accession>
    <name>A0A7W7T417_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22087" checksum="B8B8ABB13F6AEAF7" modified="2021-06-02" version="1">MADESRPGRPLRADARRNRGLLVEQAKIAFAEAGVDASLDEIARRAGVASGTLYRHFPTRLDLIEAVLAERIAGLVDLGGRLLTAEDAVDGLTAWLRAVVEHGLTYRGLAAAVLNSVTSDSGADRMSTWHAQLFETGGALLAKAREAGVVAADVRDADVLKLVGAIAWAAQDSPDRHAQADRLLALVLTGLRVRPEPIRPQQHRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G8</accession>
    <name>A0A7W7T4G8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="106" mass="11943" checksum="46C6D18060C1277E" modified="2021-06-02" version="1">MRRLREGVHPALTDEGGVLLDEHTGTWTLLTPTAASAFTTLLAAPDLDTAATRFACLHRIDPDVAGRDLRAVDRRLREDGLLTTGPDRPPTTTDRLRKWWRRRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T551</accession>
    <name>A0A7W7T551_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21943" checksum="9958878CE2218F7A" modified="2021-06-02" version="1">MSPLRKDARRNRELLVEAARRLFAGRGLGVPLEEIARAAGVSIGTLYNRFPQRADLVDAVFADRVETVERIAEHALTMPDPWEGFVHFLERICELQAADRGFNDLASRRPPGDGLELMTRIVDRAKDSGALRADFTLGDVAFLTWSTARTVEVVGAVRPDLWRRHLGIMLDGLRASAAHPLAEPPISPEHLGQAMAGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T568</accession>
    <name>A0A7W7T568_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14982" checksum="4C9921F2DF8AC53E" modified="2021-06-02" version="1">MSDITALWSSARLPIEDGLYFADGRSYAVEVDERGLRLVESFDLGDLLAEDPERLTSIDITGEIRVPDGYACAGEGAHGSEGFFARLDEDHSLIWVCYLSASNPFGELTVKASTLTAISTSGLSITLPLDDPDKALPAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5A5</accession>
    <name>A0A7W7T5A5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate reductase beta subunit</fullName>
            <ecNumber evidence="3">1.7.99.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10557">
        <property type="entry name" value="NarH_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="173"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="564" mass="63102" checksum="70C4D6407B1E73FD" modified="2021-06-02" version="1">MRVMAQMAMVMNLDKCIGCHTCSVTCKQAWTNRSGVEYVWFNNVETRPGQGYPRTYEDQERWRGGWTLGKRGRLKLKGGGRLRKLLTIFSNPKLPSINDYYEPWTYDYDNLTSAPLQEHTPVARPRSLISGEPTKITWSANWDDNLGGSPDHGHKDPLLKGIADKVKFEFEQTFMFYLPRICEHCLNPSCAASCPSGAIYKRSEDGIVLVDQDRCRGWRMCVSGCPYKKVYFNHRTGKAEKCTFCFPRIEVGIPTVCAETCVGRLRYIGLVLYDADKVLEAASTPDEKDLYEAQRQVFLDPHDPVVAREAERAGIPRDWIDAAQRSPIYSLINTFKVALPLHPEYRTMPMVWYIPPLSPVVDIVRDTGHDAEDHGNLFAAIEALRIPVEYLAQLFTAGDVEPVNAVLRRLAAMRSYMRDINLGREPREAIATKVGMTGEQVYDMYRLLALAKYDERYVIPPAHAEQAHGLEELATECSLDYEGGPGMGGSGPFGESSGGVSPIAVENFRMLRDRQTSDTMAAPVDKGARVNLLNWDGKGRPDGLFPPKEQPGGGDPAGEVDPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J1</accession>
    <name>A0A7W7T5J1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="PTHR31891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="337" mass="36087" checksum="39A758545A9EE060" modified="2021-06-02" version="1">MSIEVVGLTADPERLGYVFGGREPVLTVKPGTVVELATEDCFGGAVRGVDDLPSRVCTFPYLNPVTGPIAVEGAEPGDTVAVHFVDIRPVRDWAISTTFPHFGALTATHTTAMLHDALPERVWRYEVDVDRWVCRFQARSSEFSVELPLDPMHGTVGVAPAANEVIMSITPGAHGGNMDTPEMRAGTTAYFGVNVPGALISIGDGHCRQGEGEVCGTAVEAAMATVVVVDLIKGATTPWPRLESADHIMSTGTARPLEDAFRVSQHDLVGWTADLLSLDILDAYQLVSQAGLAPAGNVVDTNYTMLAKFPKNLLTTTPYADIHTRLRATATTYLSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R0</accession>
    <name>A0A7W7T5R0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple sugar transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031495695" evidence="4">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="42239" checksum="07D412BD7811C510" modified="2021-06-02" version="1">MRWRAVLVVSLTVVVGACGGGGPEPAPDTGPKTVIGWWDGLGGTPEVSAAVDAVIKRYEDEHRTVDVERKVFAADEFEQAVDQAAASGSLPDVLVLDHLDLPHRQAALADVTDGFGKLPFKDTLVDSARDAVTVAGRVRAVPFRLGTVGLVVNRDLVPTVPTTWDEVRDKARQAATTGKHGLCFAGTEAASTYLPLLWRDNGDLRDADASATALSYLDDLVTTGAAPKDLAGWSRADLEREFGAGRCAMMIDGPWSVPVLNQTGMTWQSGPLPQDSPSPLVGEVAAVSDRSAHRDVAWALLAWISGTRDNITQLGGVLGALPYQRDMIEDFAWQWDPNALGFSRQMPHTRAGTRYSDTFRDVTDILSATARQVLTGEAEPAGAAAQAVGAITPHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T649</accession>
    <name>A0A7W7T649_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="149"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="33511" checksum="4F33BC9233B3EA0A" modified="2021-06-02" version="1">MNSTGGTLISVTDLTDGDLRHIVDQGVRFGQADAPGRPLHGRVVGVYFSKTSTRTRTAFTSGALRLGADVIAYGPNDLQLNTGESIADTGRVFAGMLDLLVARTAGAERDLRELAASGLPVVNAMSELEHPTQALADLTTLTARFGTLDGLRLLYVGEGNNTCTALALALSRFPGVHFEARTPPGYGMPASIVETAVAQAASSGAVVVERHDMDDLPADVRVVYTTRWQTTGTSKPDPDWRTVFAPFQVHDGLFAGSPDALFMHDLPAHRGEEVTAEVLDGPRSIAFEQARYKMFSAMAVVQWSLLGVPSQTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T679</accession>
    <name>A0A7W7T679_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-polyprenyl-6-methoxyphenol hydroxylase-like FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="478" mass="51631" checksum="BD3FA9C3CC37A4CB" modified="2021-06-02" version="1">MDSSPTSADFDVIIAGCGPTGAMLAAELRLHDVRVLVLEQETEPVSFVRIVGLHIRSIELMAMRGLLDRLLDHGRRRPAAGLFAAIPAPEPAGLDSAHAYLLGIPQPVLVRLLEEHAVDLGARVRRGRAVTGIEQDDDGVTVTTADGERLRARYLVGCDGGRSTVRKLLGVGFPGEPSRTDTLMGEMAVDAPPDEIAAAVAEARKTDRSFSLTPFGDGMHRVVVSLKGLGDRTEPPTLDDFARRLRAVAGTDFGVHSPRWLSRFGDATRLADRYRVGRVLLAGDAAHVHPPAGGQGLNLGVQDAVNLGWKLAAHVRGRAPEGLLDTYESERRPVAQDVLDNTRAQVEIQSDGPGARAVRRLLTELMAVEEVNRLLIGKIIAIDLRYDFGAGPDLVGRRLRDVDVASGRLYDLLRRGRGLLLDRIGGLGVGDWSDRVDHLADATAAVDVPALLLRPDGHVAWVGDDQRELDGHLTRWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T681</accession>
    <name>A0A7W7T681_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="14832" checksum="D67036CA28598794" modified="2021-06-02" version="1">MREPLTSALTRAVRAVTGRVEEVLRPEGLTLDQWLVVAALADRRGLTMSELTACTPASGPTLTRVVDKLVGRALVYREVDPEDRRRVRVYLGQRGRALYRRVSVKVDEVERDLLGRSGPRALDVLNRLADDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T683</accession>
    <name>A0A7W7T683_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="39461" checksum="F2C5A89B5B19E1C1" modified="2021-06-02" version="1">MTPETRLQLAAHPVAYPLLRGIALLGPAVRVPRVGVVVSDAALAKEVLTDTAKFTKTGPGSPADLWTPVVGPSVLLNMDGAAHVALRRKLSGLFTPRAVAGLCARAGEGPLSRLRDDLASGHEVDLVAVVRDLVGAVICGLVGLDAAQARQAADAGSAITGMVRLGRPRLGPAQVARARAALGTLTTPAAKAYAEGDPSTVPGRMRELGLGEDEALGAVAAFVLTGTETLVSYIPRLVALLHDSGWLTRLLAEPERTGDVVAEALRVTVPSPVMLRSVAVDTWVGPVAVRRGDRVVIATISACALGPFDPDRPHPHAVRQLWFGAGPHFCLGMPLADAEIRAFLDAVLSAAPVSIVERKAARRVLVPHYERLVVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T725</accession>
    <name>A0A7W7T725_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">F4559_004870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="32"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="207"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="468" mass="51099" checksum="26624771F59905A9" modified="2021-06-02" version="1">MTDLDGTWADESDWAAFDDADFADDQAAAPQPVLAVVGRPNVGKSTLVNRIIGRREAVVQDVPGVTRDRVAYDALWNGRKFTVVDTGGWEPDATGMMASVAAQAELAMNTADAILFVVDATVGATTTEEAAVKVLRRSKRPVLLVANKVDDERLLAEVASLWSLGLGEPLPVSGLHGRGSGDVLDKILDVLPETPRDTFESARGGPRRVALVGRPNVGKSSLLNRLTGEERAVVDSVAGTTVDPVDSLVELDDEVWRFVDTAGLRKRVNFASGAEYYASLRTKAAIESAEVAIVLLDAAEPLSEQDLRVLSMVVDSGRACVLAFNKWDLVDEDRRHAMVRELERGLVRVPWAERVNISALTGRSVRKLAPALRTALTSWDTRVPTGRLNSWLTELIAATPPPVRSGKQPKVLFATQAATRPPTFVLFTTGFLEAGYRRFIERRLREEFGFEGSPVRISVRVREKRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T793</accession>
    <name>A0A7W7T793_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recO</name>
        <name evidence="10" type="ORF">F4559_005228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RecO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27084" checksum="5E52DE8A8D1C5D92" modified="2021-06-02" version="1">MANLYRDTGVVLRVQKLGEADRIITLLTQRHGKVRAVAKGVRRTSSRFGARLEPFGHVDVQFYPGRSLDVVTQVETVDAFGVALVDDYQRYTAACAVLETADRLTAEEGEPVLRLYLLVTGALRALAAGERDASLVLDAFLLRAMAFAGWAPAVTECARCGTPGPHRAFNIQAGGMVCPDCRPPGSAQPHADTLRLLIALLHGDWSGVDGVPAVHRREASGLVAAHLQWHLERQLRSLPLVERRPPAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G5</accession>
    <name>A0A7W7T7G5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8331" checksum="795E10D3317A6E1A" modified="2021-06-02" version="1">MIHEWPFPDGLVDYPADVKALGPVVNIVVRSRWVVSAKEDASGGRRARSSGGGCPAAAEWHSSGHRHLVWSAVKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I2</accession>
    <name>A0A7W7T7I2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="6847" checksum="77CD0C5BB9B09E20" modified="2021-06-02" version="1">MCTHHRDQAGSVTRLSHSTDSVRITAVSPRATADESVRITLHDDSVRITAHGWNPAVHAGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I9</accession>
    <name>A0A7W7T7I9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="4" type="ORF">F4559_005140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="80" mass="8467" checksum="0AD007CAB899C1DA" modified="2021-06-02" version="1">MSNEDIQVGLAEIVEEVAGVAADDVTPDKSFVDDLDIDSLSMVEIAVQAEDRFGVKIPDDQLAGLKTVGDAVDYITANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T817</accession>
    <name>A0A7W7T817_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24159" checksum="A1949E65D26BB098" modified="2021-06-02" version="1">MNDSNAGRPGASDPVAEGVVDLLGALAYGELSAFERMAEDARSAPTLSGRAALARMAAAEIGHYGAIERYLADRGHTVEEAMNPFVAGFDAFHTSTAPKSWLESLVKAYVGDGLAADFYREVAEWLAEPTRSLVLEVLADSGHSAFAEREVRAACEVDPTLRDRLTLWGRRLLGEALTQAQYVVAERDGLAELIVRGSGDLAGIAALFRRLQQSHTRRMTALGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T818</accession>
    <name>A0A7W7T818_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043864">
        <property type="term" value="F:indoleacetamide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031497522" evidence="1">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="493" mass="51691" checksum="0038A08571C3B91F" modified="2021-06-02" version="1">MRPLLAAVLAVVLIAPPAAAHPVGLGFDLDAATIPDLVRRLDAGTLTSVRLTREYLRRIETVDPKVNAVLAVDPRALEQAAASDRRRRAGQARGLMDGIPVLLKDNIDTAGYASTAGSRALSTPPSVDAELVTRLRRAGAVVLGKTNLSEWANFRSTRSTSGWSGVGGQTNNPYVLHRNPCGSSSGSGAAVAASLAQVAVGTETDGSIVCPSGQNGVVGLKPTLGVVSGEGIVPLSTRQDTAGPMARHVVDAAILMSVLGGVDHRAALRPGVLKGARIGLWRLAGNAGVDRVVARSVEVLRRAGATVVEVDLPYQDRIGEAEFPALTVEFKHDLEKYLRTRPGAPRTIASLVGFNRADPVELSKFGQELFEAAVDAPGVDDPGYREQRATATSLARRSVDEVLAANDLDVIMAPTNSPAWKTDYAAGDAYELGSSTPAAVAGYPNVSVPAGFVGELPVGVSFFAGYRADVKVLRFAAAFESEARARRAPRYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T823</accession>
    <name>A0A7W7T823_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031004678" evidence="1">
        <location>
            <begin position="25"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="520" mass="55035" checksum="80490F97E0ADC8CC" modified="2021-06-02" version="1">MRRLLLLTLAVPFLASCTVVVAGAPSPGVKFEKNAPSAAPPGLERFYSQQLGWEDCGPYATTATAQSQFKNRKSLECTRIEVPLDYAKPDGKVIKLGLLRQKASGERIGSLILNPGGPGASGMEAAASLSTSVRRTPVSEHFDLVGFDPRGVGASEPAVKCLSDTERDTDRLDNDVDTSSAGIAQTEAENKAFADKCAAKMGADVLANLGTRDVVKDLDVMRSVLGDTKLTYLGYSYGTAIGTAYAEAFPDNVRALVLDGAVDPTQTEAESLVAQGAGFQKAFEEFAAWCARRDDCALGKDVASASKTFRELTLPLVQNPIAVGDRKLSYGDAITGAIQAMYSNDLWTPLNTGLAELRGGKGDMLLTLADAYFGRDEDGRYSSITDAFTAIKCVDEPRLTDRTVLDDIARKYKAAAPFLDDGNPAVGALDACAFWPVPPTVTPHPPSVKGLPPVLVISTTGDPATPYDAGVNLAQALGGSLLTFEGNQHTVYLQGNSCVDPIGHAYLVDLTLPDKGKRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T824</accession>
    <name>A0A7W7T824_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="34724" checksum="7DF89A01DF626ECB" modified="2021-06-02" version="1">MVSPGVVILGEVRTSLLHTSLPLPRKSVVDLLSLRPGRQVVATDRPINRTVSPDSVVGVDCALATEPQARARGIGTVASHAVVVGGMVLQASARTSCEWVEYRERRAWSHYARRRGVLDVLGNSVPEQVVRGSKRAVRVPETLDLGSVCQRLLAAVQGRPQLDHRTRLRARPTRLRWNAVVEPDVRPSVHLHIDDDVQRTVDLVVPPEAASAAVVFCEDLALHDWLYTTLGAVVEEAERDVDVGADPMRVLGAALSLLVRLWLPGKHVDPVLRPLWDDLEREPGFSTAWHQNVAWMRDQVSITTLSAWQESRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T866</accession>
    <name>A0A7W7T866_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="32079" checksum="D96E0B64E43700F0" modified="2021-06-02" version="1">MSALSAGRKAERRLGLLLCLPAILVMAAVAGWPIVYSVWLSLRRYDLKFPDRTEFVGLDNYVTVLSSPYWWNALWITVVITVVSVAVELVLGMALALVMHRTLVGRGIVRTSTLIPYGIVTVVAAFSWRYAWTPGTGYLAELAGGDPVLTEKVPAILTVILAEIWKTTPFMALLLMAGLALVPEDLLKAAAVDGASAWQRFTRIIVPVMKPAILVALLFRTLDAFRIFDNLFVLTAGSQGTSSVSMVTYNNLIKGLNLGIGSTMSVLIFLAVALIAFVFIKLFGTSAPGSDSEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M4</accession>
    <name>A0A7W7T8M4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_005938</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="14">
        <location>
            <begin position="127"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="15">
        <location>
            <begin position="341"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4968579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="524" mass="57872" checksum="A8B1EBE43165B925" modified="2021-06-02" version="1">MSLIAPQSADDDVVGVGEVPPTSPPPGNDRAARADQLEPGPTSSALRGWLVTLAVALIGGVVRFWNLGFPTDKGTPMFDEKHYVPQAAQVLRNGGYEDNPGYELIVHPPLGKQLIAIGEWLFGYDGVGWRFASALAGTVVILLVIRIARRLTRSDLLAAIAGVLMIAEGLSHVQSRMGMLDSFITLFVVVSFACLVADREQIRARLAIAVREGWVGNSPFGPWLGFRWWRFAAGISLGLACGVKWSGAWFILFFGVLSMFWSATARRAAGVERPWLGSFAKDLLPSLLALALLPILAYVATWWAWFGSETGIDRHIVGVKVTGDSWIPDPLRALWYNSSNVLEFHTKLLTTETNKHPWESKPWTWPMGLRPMLYYYEGTTTGCGAATCVGAIMLVGTPAMWWLAFPVLAWALWKSIAQLDWRYAAVLVGYGAGFLPWFTNVDRQMYYFYAMPMAPFLVLGITLALGDILGAKKAGKERRGTGLLVVALYVGLVVANFVWLWPILNGIPITPEMWDAQRWLPSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T2</accession>
    <name>A0A7W7T8T2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase (GGCT)/AIG2-like uncharacterized protein YtfP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGACT" evidence="2">
        <location>
            <begin position="240"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="38318" checksum="08DD1028C24F6DA7" modified="2021-06-02" version="1">MTQPFTDDSHPAEPYPGARPGHCFVHLDGEGWPVTPDPATDSGWRVAPDGRDLDDWLADHGEPPLAHRMPVLAYGSNANPSKVTWLREELGLTGPAVVLRAKCRDLSAVWAAGHRKSDGQRPATLAHAPGVEEEHAVWFATAEQLRVLDRCEGRGLRYRLVRVHSGQVTLFDGAVVDSVLAYTGAGKRRMPLLYGDRPIRCADVPQHRARYQPGRPAASDGLDVTPVHGDPSPDDWPDLIFVYGTLRPGMSGWHLVADHVVEATPVTVTGTLHDTGRGYPALRPGAGSVPGHVLRLDAPEDVLPALDEYEGDEYRRVRVTLPDGRVCWTYLWTGGVEGMAVLPDGWVDNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z5</accession>
    <name>A0A7W7T8Z5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17440" checksum="B172EFE9D7BFAFB8" modified="2021-06-02" version="1">MTDIDPRDDRRGPEDTAVLTELNRLVYELDAPPLGLVERIQFAVALENLDVEVARWERAGSFAGVRGGNPGTITFTVDNLTLMVNFTSTGARHRIDGWLVPAGEHTVEVRVAEHESSTTKADDGGRFVLADVPAGTTQIVVHLVNSRGEPGRTVVTPTIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T994</accession>
    <name>A0A7W7T994_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29517" checksum="6534D987D0AAC0D2" modified="2021-06-02" version="1">MNAIRVRGLRKSYDGKPAVAGIDLEVAEGEVFALLGPNGAGKSTTVEILEGLRRRDGGEVSVLGQDPAKAPRSWYEDIGVVQQAATDLADTTVAEAVRHFARYYRRARAVDEVIDLVGLTEKAGDRAGKLSGGQRRRLDVALGIVGRPKLLFLDEPTTGFDPEARRRFWSLIRLLAREGTTIVLTTHYLDEVEALANRLAVVARGRVVAEGTPLTVGGRHTADALVSWIDNRGPQSYRTPRPDEFVRSLPAAPGLTVTRPTLEDVYLELIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F9</accession>
    <name>A0A7W7T9F9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="31181" checksum="D54C7AE8F2D11AD7" modified="2021-06-02" version="1">MTVDTSEADARFKKWMRENLTRAAEHFGLVVSGEPVLGWVDRSISAPVRKDGSDYWLRVVSEDKQWIGGNFWTGNLDANVFDGLAKPRVLDVFEWEEWRQQRAEVMTRMPGTPCSLTDALRVAVDLSDQWWAELRRTVDTVAATSTTRVNSGPDKLAERLVQRFGDVVDVTAAEWETVHGDLHWANLFGPRFGLLDWEMWGRGLKGSDAATLLCYSLLVPDVAERVRAVFADVLDTSAGRVAQLYVVARLRRRVDGGEYPDLAGPLDRLTSSLLVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J0</accession>
    <name>A0A7W7T9J0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="28485" checksum="C1FBE2B652EF369A" modified="2021-06-02" version="1">MESLRVVSSWPVDHVAGAVVDADGRVLGTVGDVDRRFALASVTKLLTSYAVLVAVEEGAVEWDRPAGPEGSTVRHLIAHTSGYGFDSLQVQAAPGTKRIYSNSGFAVLAETVATAADIPFADYLREAVFAPLGMTSSSLDGPAGSGATAAVADLVRFAAEVQNPKLVSPELVAEATSVVFPGLRGVLPGYGSQRENDWGLGFEIRAAKSPHWTGTTSSPRTAGHFGQSGTFLWIDPDVRAACVVLTDRPFGQWAVEAWTPFTDGVLAELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V4</accession>
    <name>A0A7W7T9V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructokinase</fullName>
            <ecNumber evidence="4">2.7.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.4" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="32716" checksum="8444DFBC3133C6C7" modified="2021-06-02" version="1">MIVVAGEALVDLVPTPDGALAPRLGGGPYNVAVATGRLGTPTSFLSRVSTDLFGDRLIRRLHASGVRTDLVRRGTEPTTLAVVGLAEDGSARYSFYVEGTADRLVVDPGPLPDGTDAVSFGTLSLVLEPGASTYERVLWREAERGALTVLDPNIRTGLIDDPLAYRDRYDSWLSHVGLLKLSIEDARWLADLDDDAGLPDVLDVARDWQRTGPAAIVLTLGGDGLVVLSGTGEVIHVPPVPVTVVDTIGAGDTVHGALLAWLHAHDALSTEAVRGLDRTNWAKALGYAGAAAALTCSRAGAEPPFSAELGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Y8</accession>
    <name>A0A7W7T9Y8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine deiminase</fullName>
            <shortName evidence="3">ADI</shortName>
            <ecNumber evidence="3">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arginine dihydrolase</fullName>
            <shortName evidence="3">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arcA</name>
        <name evidence="6" type="ORF">F4559_006550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3 4">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="415" mass="44581" checksum="01B0173BE0E65C68" modified="2021-06-02" version="1">MTAHIAPTETADAVPHPAPRVDSEVGPLRTVLLHRPGAELKRLTPRNNDQLLFDGVPWVDRAQEEHDAFAEVLRVRGVEVLLLSDVLVAALHDDRARIAGLHSAVDERRLGIDLADALRSHLASLPPDQLATVLTTGMTFEELPAAEGASLVRKMHHPNDFAVNPLPNLLFTRDSSVWVGDRVAITSLALPARDRETALTDLIYAYHPRFRRTRRAYGAHSAPLEGGDVLLLAPGVLAIGVGERTTPAGAESFARSALADGLAHTVLAVPITQERATMHLDTVCTMVDRDAVVMYPAVRDSLEAYAVRADGSGGVTVADRKPFLEAAADAMGIERLRVIDTGLDPVTAEREQWDDGNNTLAVGPGLVVAYERNVETNARLEDAGVEVLRISGSELGSGRGGPRCMSCPIERAPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z1</accession>
    <name>A0A7W7T9Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin--NADP+ reductase</fullName>
            <ecNumber evidence="10">1.18.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006623</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="363"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="445" mass="48812" checksum="9E2AF396968A2077" modified="2021-06-02" version="1">MTRSLRVAVVGAGPAGIYAADILTKSDVEVSVDLFERMPAPYGLIRYGVAPDHPRIKGIVNALQKILDRDGVRFFGNVEYGVDLKLDDLRHFYDAIVFSTGAEKDRPLDLPGIDLPGSYGAADFVSWYDGHPDVPRTWPLDARQVAVLGVGNVALDVARVLAKTADELLTTEIPDNVHAGLKASPVTDVHVFGRRGPAQAKFTPLELRELDHSPNVEVIVHPEGIDFDAASMAAIRSNKQVEMVVKTLQEWAIRDPGSRPRRLHLHFLEAPVAIEGENKVELLRTERMELTGDGNVRGTGEFTDWPVQAVYRAVGYLSTHLSDLPFDHVSGTVPHQAGRVLDLDEQHIPGVYVTGWIKRGPIGLIGHTKGDALETVTSLLADAEHRATDATPEAVVRFLEQRAIPFTTNEGWLKLDAHEKALGTAQGRDRIKVVDRDEMTGISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAD9</accession>
    <name>A0A7W7TAD9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate monooxygenase</fullName>
            <ecNumber evidence="2">1.14.14.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="363" mass="39358" checksum="EDC81BAB0531DC20" modified="2021-06-02" version="1">MSVVTHWFLPTSGDGRTIVERFHANPTQGTPASRGPDIDYLAAVASAAEVNGFTGVLTPTGTWCEDAWLSTAALLARTSRLKFLVAFRPGAVSPTLAAQMAATYQRISRGRLLLNVVTGGDAIEQRRFGDWLDHDQRYARTDEFLRVVRSVWGGEPVDFTGEHYRIAGATLPAPPDPIPPVYFGGSSDAALPVAARHADVYLTWGEPPADVAAKIARVRALTDRPVRFGVRLHTISRDTSEEAWREAGRLLAALDPRRVREAQERLAASESVGQQRMVALHGGAFDGDPRGLEVHPALWAGIGLVRGGAGTALVGSHAEVADLIAEYHAHGVDEFVLSGYPHLEEAYWFGEGVHPELRRRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAK3</accession>
    <name>A0A7W7TAK3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EspG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025734">
        <property type="entry name" value="EspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14011">
        <property type="entry name" value="ESX-1_EspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="18278" checksum="49E9600C60704985" modified="2021-06-02" version="1">MTNATLSAAQFRTAWEHLDLGALPIVLHVPDDPAPWSELVENDLVRDGDLDPWLGSALELVARPPRAVDLRLGIGSVAVRALAVSGERGAVLAVLSGGRLSVRDPDADLPAAVVSVLPADGDLVGAQDLHGRIGAAVLDATGRRCRSRDVVDFHGPVPADGLRERVASLLARLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAL4</accession>
    <name>A0A7W7TAL4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR02569 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013402">
        <property type="entry name" value="CHP02569"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02569">
        <property type="entry name" value="TIGR02569_actnb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28836" checksum="5DB3AA0D09246842" modified="2021-06-02" version="1">MTTPPDPPPSHVRAAFGQRDAEPEPIDGGPAWRCGDAAIRPAGNPAEATWVARTLDTLEVENLRIARPLRSTDGRYVVGGWSATRHLTGRAEPRHDEVAAVATRLHTATADLPRPRFLDARTDVFAVADRAAWGDDTPDLRPELGGRLFELLADRRKPVTAKNQVVHGDLFGNVLFAGDAPPAIIDFTAYWRPAPYGAAVVVVDSLAWGGADAGLLKRWSHLDDWPQIVLRATLFRLAVHALHPLSTTRSLTGIERAATRVLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTK6</accession>
    <name>A0A7W7WTK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031398579" evidence="1">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="34"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="27515" checksum="B2477EDEC6180F90" modified="2021-06-02" version="1">MRPIRTLATLVAAAAVAVLTALPAQAAAAENYVALGDSYSAGTGTGSYYGDSGSCKRGQYAYPALWAATHAPASFKFVACSGAKTSDVLNNQIGALSATTSLVTVSVGGNDAGFVDVITTCTLGSDATCVNRVNQAKNYTNNTLPGLLDNVYAQIRNRAPSARVVVLGYPRMYQVPGSCSVGLSDTKRAAINSAADTLHTVVSGRAAARSFTYRDLRGSFSGHEICSSAWWLNSLSWPVEESYHPNRDGQRLGYLAQLNAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTS1</accession>
    <name>A0A7W7WTS1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YbjT (DUF2867 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="280" mass="29480" checksum="5DD6497B9916250A" modified="2021-06-02" version="1">MILVIGGTGTTGRAVLRSLSVPTRALVRRPGGLPPGVEQVVGDAADPGPLRAALTGVSGVFLAMGNGPRQEAIELGVVAEAARAGVDHLVKLSAPSAAADSPVAIARLHHRVEEAVRASGIAHTFLRPYAFFQNLLFHAERVRAVGWFPAATGDTPLNMVDARDVADVAVAALTRRITGTHLLTGAEAVSYPEVAARLTAAGRPTRCVTVTPDELRADLRGAPDWLVEHVVEIQRLATTHPERPNDTVARLLGRPPRRLDDFMAEHAGAFGGPIRTDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTT3</accession>
    <name>A0A7W7WTT3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ORF">F4559_000840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019856">
        <property type="entry name" value="CRISPR-assoc_Cas1_DVULG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03640">
        <property type="entry name" value="cas1_DVULG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="37171" checksum="A5FD73FE6C727BC1" modified="2021-06-02" version="1">MTELLRTLYATTPGSSLHLDGDALRIVHPDKPGRHLLPLVRLDHIVAWNGVSVTDDLVHRCAADGRSVTWITRNGRFLARTGGPQHGNPFLRLAQVRAYDDEDRRLALAQSFVAGKLHNYRQLVLRAARDASGSRQARLRGIADHHADALVQLGGASGLSEVLGIEGRAARSYFEALDQLSPGVATGRSRRPPTDPVNCLLSFGYGMLRVAVHGALEQVGLDPYIGYLHGVRPAKPSLALDVMEELRPLLVDRLVLTLINRGQVTAKHTETLPGGAVQLTEDGRRHFLERWTQSRERLWPHAGLGREVPAGLLPLVQARLLAKHLRGDVDAYQPWTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTU8</accession>
    <name>A0A7W7WTU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NBD/HSP70 family sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="397" mass="40806" checksum="52044F4794CCE225" modified="2021-06-02" version="1">MTVRPSPQVGTPAGMRVLNQRAVLDRLRAGGPATRPQIAKDTGLSKPTVGQALLDLERRDLVRPIGRTTAGPGRSAMVYETNPAAGHVLGVDIGRRRIRAAVADLAGSVIARVDERNRCRTATTLVRTVKELAARTVADAGLVAEDVVVTVVGTPGVPDRSDRTLRHAPNLPGWERRGLLDDLEAELGPGLVVVENDANLAAVGEYAHGAARGVGVFVCLTVGTGLGMGIMVEGHLFRGANGAAGEVGYLPYGAEESVVDDLGRGRIEAAVSGDAVVALARDRGLAVKSAREVFALAKSGDERARAVVAAEADRLAHVVASVAAVVDPELVVLGGGVGGSADLLPGPIEEALCRITPLRPRVVAGALGDGAVLGGAIARALVSANDLVFDRKDAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ0</accession>
    <name>A0A7W7WTZ0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="226"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="344" mass="37835" checksum="252D51DF739C011E" modified="2021-06-02" version="1">MRRIRALVTVGGEFVGAAPDFDVESFWLNATEDVVAHLEAVLGVPVSVLRLERTTEARRSGDLVVYQVEAEAMPRVPLDRSVDHDFPDHPLRVPWARPGGPRSLVEWADRHVTRTGPAVQVKTWHLSCVYRLPTDRGPVWAKAFPGFVADEAAVIALVREVDPTLVPEVIASEPGRVLLADVPGEDCWNPTPEVIADVVPRLVAVQHALAGPARSRVRGIDVPDFGLPDTLLHGDFHPGNWRSSGVVLDWADAHWGNPALDVGRLLGFVDPASHPLIERTWADAWLAHRPDSDPHQAIRHGRHASHLLGALVYQDFLDHIEPSERVYHEGDPAAERAKAQASLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF1</accession>
    <name>A0A7W7WUF1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme exporter protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="3">
        <location>
            <begin position="292"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="529" mass="55323" checksum="0E0BF872B80349B0" modified="2021-06-02" version="1">MPSKPAGNSAAVGGGAEIGSGDRAGTAAATGTDADTVGEPGTGSPGGCTDSATDESNSAARTGPVVVVPPPSPPGRRDPEAGEPGYRSPGQVLALAAIGGVAAAVAVPLDRPGIGWVLTSLVLFALVRKVNYVWATLCVSLLAIGALHDASWLFVLCVIGAFAAGSLAVARGTSGFSLLVGALAVPISSFRALPWLARRGPRDATSRFVRPVLLTALLLAIFVPLFASADPDFAALLDAVVPDVGGGTIFVFLTAAAIVIGSCFVLVRPIVPLETPSRRRALPRDWAIPVGALVLVFAAFVGVQIGTFFGGTAHVMTTADLTFADYARGGFWQLLAVTVLTLVVITVTAQAARIDTATDRLWFRGLLGTLSVLTLVVVASALTRMWAYQQAYGFTVLRVLVTTIELWLGGVYLLVLAAGIRLSGAWLARAVTVTAMVALLGLAALDPERYVADRNVDRWQATGVIDLRYLADLSDDAVPAFARLPTVFRACLSERRPETPADGWREWNLSRHRARVMPHDEPPCIHPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUU0</accession>
    <name>A0A7W7WUU0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="26895" checksum="B28DF0DCAF5C32EF" modified="2021-06-02" version="1">MRILRSDYETTVVEALKETVDALVETINRGSVKRSSDCTDKIGQTTFGVDLIQYVAGRVWVEEPPVTDPNTDTVLSRRGHAEQVVRWAVRTMDNNGTHYADTDDRTEADARYEYEVRQLADCAEQGTVWWHRTDVDGVPQCKFAYTIETHEIDGDWQRVESDRDMLGENEYGGQEDHEDAALRLAGRYVDEWDLDDTAAYDAVRVTVRRDGDDPILVVTVTTEGHDTVHAARPTGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV36</accession>
    <name>A0A7W7WV36_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine N-alpha-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Histidine trimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">egtD</name>
        <name evidence="5" type="ORF">F4559_002268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:38471"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15781"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. EgtD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.44" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030745">
        <property type="term" value="F:dimethylhistidine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02037">
        <property type="entry name" value="EgtD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035094">
        <property type="entry name" value="EgtD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032888">
        <property type="entry name" value="EgtD_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03438">
        <property type="entry name" value="egtD_ergothio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_33" evidence="4">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-histidine binding" evidence="3">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="35473" checksum="0BE7C2A2DABED745" modified="2021-06-02" version="1">MTEPVLDVHLTPEDAALALRAEALAGLTAPAKWVSPKWFYDAVGSDLFEDITRLPEYYPTRAEREILEARSTEIATVTGARALVELGSGSSEKTRLLLDALRAHGTLAEFVPLDVSSSALVDAARSILESYPGLRVHGVVGDFTEHLGLLPGASPRLVAFLGGTIGNLVPDERAKFLTSLRDVLAPGEWLLLGTDLVKDPDVLVRAYDDAQGVTAEFNRNVLHVINRELDADFDTSAFRHVALWNPDAEWIEMRLRAAHPTRAHVGALGIDVEFARDEDLRTEVSAKFRRDGVARELASAGFTLHSWWTDTQSRFALSLSQATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV62</accession>
    <name>A0A7W7WV62_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding Zn ribbon-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010852">
        <property type="entry name" value="ABATE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023286">
        <property type="entry name" value="ABATE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021005">
        <property type="entry name" value="Znf_CGNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35525">
        <property type="entry name" value="PTHR35525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07336">
        <property type="entry name" value="ABATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11706">
        <property type="entry name" value="zf-CGNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160904">
        <property type="entry name" value="SSF160904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-CGNR" evidence="2">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="20180" checksum="A4CBF8F7A3A9A6DB" modified="2021-06-02" version="1">MSTDRNRSAPADPRPLTGEPPALDLLNTRWRGASGLEDLLSDLHGLAIWLSSAGLDSRAEADQDTLDALLRTREALTSAVTSPVDATALNDVLAKGRLRLSLVAGVPTEEIDLDDPAWLPGWLAARDYLDLVTRGADRIKPCANTNCVLHFFDTSKNGSRRWCSMAGCGNRAKAGRHYARTRTRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA4</accession>
    <name>A0A7W7WVA4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="2">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="301"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="487" mass="53944" checksum="174269088C81B230" modified="2021-06-02" version="1">MTTPRQKAVAPVTATTDGKPLRIALISEGTYPFHSGGVSLWSDQLVRGMPEHEFTAVALTVDGRERPTWTYPDNLVEVVSIPLWGRPPRRARRTPPGFAATHEALLRSFIPHTDDSPAAFLAALRRLFDDAQSWDVSTALSSNEAVDRLIDVVEEGYGMRLSLRDAITATDLLEHMLRPLSHPPVKADVCHLAMNGLSALVAFAGKWAYGTPVIMSEHGVYLRERYLGMINETMSRPVRRVLMGFHRALACAAYRLCDMLTPHSSYNRRWQLRNGADEKRMSTMYNGIDPEDFPLAEGEPDVPTIVFVGRIDPLKDIHTLVRSFQLVHKELPEARLRMFGPVPAANKAYHAGCVQLVEELGLTGAAVFEGRVPNQVDAYHAGHIVALTSVSEGFPFTVVEAMSTGRTTVCTNVGGVSEAVEDAGIVVPPRDHEAVARACLRLLKDDSLRRELGKLARQRVMEYFTLQRWNDSYQARYAELVLLGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA8</accession>
    <name>A0A7W7WVA8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010152">
        <property type="entry name" value="CRISPR-assoc_prot_Cas2_sub"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09707">
        <property type="entry name" value="Cas_Cas2CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01873">
        <property type="entry name" value="cas_CT1978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="13481" checksum="DC4817E0CAD62C63" modified="2021-06-02" version="1">MTVIVVAACPVGLRGHLTRWLLEISPGVFVGNVTARVRDLMWSRVVELVRTGRAIMVHRADNEQGLDFKVHHHDWHPVDFDGIQLMLRPSTPPSDSETTTTPSTSWSTAGRRRRFGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVC4</accession>
    <name>A0A7W7WVC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="13269" checksum="94B08B35231131CC" modified="2021-06-02" version="1">MNRAASGVAALAAGAVLGAVGTALPLYGVVRPGGRTEVLVTAWHGLGSGSARLALPAVVGVGVLVVAVALSVLRPGVLGRFLAAVGAALSVGVAAVVATVVAGVLAADPSAYLGSGAVLLAVASVIALVGAALVQDWTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVE2</accession>
    <name>A0A7W7WVE2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme related to lactoylglutathione lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="13020" checksum="B7FD814C32096997" modified="2021-06-02" version="1">MPTTGPDFISLQARDLAASQAFYERYLGLVRSPAGPPHAVVFETKPIAFALRDIVPGTDPDAVAQPGIGVAIWLHATDVQDIHDALAADGHTIVSAPIDGPFGRTFTFADPDGYRITLHDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVN7</accession>
    <name>A0A7W7WVN7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031364442" evidence="1">
        <location>
            <begin position="27"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="334" mass="34327" checksum="5C30888647687389" modified="2021-06-02" version="1">MRFPLAAGIAALLVASTLTSATAAQAATCRDVDARVNVLATTHVVHGTLCTPEGGSGTVQVLIPGATYNSTYWDFPDGTHSFRTAQNAAGFATFTLDRLGTGGSSRPLSVLLTSFVQADAVHQVIDGLRAGAYGPSFSRVVVGGHSLGAAIGVLVAATYPDSVDGVLVTGITHRINTVGFALAFANFVPANLDPKFGLLYPVGYLTTAPGTRYASFTAPAVRIPTVQTIEESTKDVFSPTEAADALGFGMLLPYSLQITAPVLVVVGGQDSCLCGLLATDCSSSAGLRASEAPYYNADLETLIVPGAGHSLNLASSVGEYHATVSSWVTRKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVV5</accession>
    <name>A0A7W7WVV5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase</fullName>
            <ecNumber evidence="1">3.5.1.118</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl hercynylcysteine S-oxide hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">egtC</name>
        <name evidence="3" type="ORF">F4559_002267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide</text>
            <dbReference type="Rhea" id="RHEA:42684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:82703"/>
            <dbReference type="ChEBI" id="CHEBI:82706"/>
            <dbReference type="EC" id="3.5.1.118"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.118" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02036">
        <property type="entry name" value="EgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017808">
        <property type="entry name" value="EgtC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032889">
        <property type="entry name" value="EgtC_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03442">
        <property type="entry name" value="TIGR03442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26346" checksum="992D792F5510CB6F" modified="2021-06-02" version="1">MCRHLGYLGPAVPLSGALVDAPHSLVHQAYAPRDMRGGGTVNVDGYGVGWYPAPGAAPLRYRRAGQVWADANLLALSRVTVSGAFLAAVRSATVGMPVVDTACAPFTDGRWLFSHNGRVIGWPDAVAPLASRLPVTDLLTLDAPTDAALLWAVVRRRLAEGADPTSALETVVSEVEEAAPGSRLNLMLTDGTVLVATTWWHALWVRSGAGAVTVSSEPLDDDPAWKEVPDRHVVTARVSEVDVRPMGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW21</accession>
    <name>A0A7W7WW21_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="15454" checksum="4D2F02A8921CA9A8" modified="2021-06-02" version="1">MPRAASAATPWPWPRTPGGPSPAAHAGWAVTGLARAADRDFVLGAGARALVTDLSGRSFDAVLDAAVLHGPVLAAVRDGGAYTGVPGPVPAEPERGITVGIGSVVPDGAGLARLLDLAASGVLEARVAGRVALADAVIAYDKVAGGQRGRWLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWN6</accession>
    <name>A0A7W7WWN6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="SSF49468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="539" mass="57492" checksum="2048B56E504E6F5B" modified="2021-06-02" version="1">MSEQFGPYRIEALLGRGGMGEVHRAFDTVNGRYVALKRLPVAMANDEDFRARFRREARLLSRLSAPHVVPINDFGEIDGRMYLDMALIEGRDLDKVLAEGRLSAARSVTVISQLAAALDAAHAAGLVHRDVKPSNVLLASVAGGDFVHLLDFGIARSTTGTTGLTATGAAIGTLDYMAPERFVTGEADVRSDVYALACLLYECLTGAKPFPGGSMPSLIHAHLNVPPPAPTLKAADLPPAFDHVVATGMAKEPEARYQTPGALAAAAREALEATRVTTPRPTRLDTPPTPTRVEPPQPPTRVETPQPPTRVEPPQHPPTLFDVAPRPNPTTAPPFRHQPPPYTPNTSTPPFPVPTMPPADTGGSRKLAVVAAVTGVVAVGLAVALVVNLTGAPADTATSGTKTITTTTTTSETTTETTTTTSDEPTTTTSTTTTTTTTTTPALPDPEVKGTVDWYSCSEADVPSEPSDIPAVFTVTNDYEGNGLPILVFWIDQYGEWQHWFDVEPGQTMRQETYIGHRWALKYDSCIAVFSGPGEIYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV1</accession>
    <name>A0A7W7WWV1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 6'-N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.82</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.82" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047663">
        <property type="term" value="F:aminoglycoside 6'-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21007" checksum="047A76CD507B194B" modified="2021-06-02" version="1">MVEGEVTWRRLTEADFPLLRDWLLSPHVARWWHHETTPEAVARDFGPAARGEEPSEDLLVSLSGAPVGLVQRSRYGDYPEYIEELAPILAVHPETVSVDYLIGEVSLTGKGLGARVIRAVVDETWTSHPAAPAVVVPVSAANRASWRALEKAGFTRVAEGELEPDNPIDDRDHVIYRFDRPVADPVPTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX02</accession>
    <name>A0A7W7WX02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="350" mass="37243" checksum="21DB3E5CFED6FD01" modified="2021-06-02" version="1">MLDRLDEVPWSSLDHAYGPADDVPGQLRALRSPDADERGRAVSALYGNVFHQGTRFPASAHAVPFLLELVAAPDTPDREVLLGLLTAIAIGYDESHLPGTVPIAEYRRAAAGGAALLPDADFFEHRESLPEDDQDRLFAHVTVAAYDAVKAGVPLFRTLLADPDPGVRCQAAYALAWFPEEAEGSVAALTGPLDPDEIAAATAVVATGLLGGTPVADDRRLVRWGRAIATRDVPELLRWAGSADQGDDRIPFLGGDLAGLAASALPERAEVLDALLARVPHVSGVEALPVVGEALRRTEDDPDGRRRLLEVLAATPAVWLLGGRRFGNFVTLLAGHGVPHDIEALREYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX67</accession>
    <name>A0A7W7WX67_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16379" checksum="C4539F531D2889E2" modified="2021-06-02" version="1">MNPAPNDDDRERDRIRAAMERILAGTAENSNGALTIVALAHEAGVSRNALTQRHTDLKNEFYTRVRERGGPSEVEDRLRKTTARLKNTIANKNTELEQLRADVPALVRTINVLTLENQQLRQAREHNLPTVIPLRDRPRAPRTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD4</accession>
    <name>A0A7W7WXD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="16"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="414" mass="43504" checksum="94170E415BA71F16" modified="2021-06-02" version="1">MTTVETQLPPLRRNRDFLLLWLGAGGTLLGTRVTITVYPMLALWATGSATMAGLVGAAALLPQLLVQLPAGVLVDRVDRRRLMILADVGCVLSTLSVAVAVFLGHTWIAHLVVVAFVQGALAICYDLAERSAVRHVVPKEQLSAALGQNEARSRAAGTLGQPLGSSLFAFLHWTPFVFTAFAHLVSLVSMLLIRKDFQDERSSAKRDFKAEVVEGFRWIWAQNLLRTAMILISVSNIVFAGLGITVIFLIKQSGGTGLLVGVITAIGGVGGMLGALTATRWLKWLTMRALLVGGFAVWALTVVPVAFTSDPFVLGGAFAAFGYVGGVFNVAGGIYLVSVAPDAMMGRAVSVMTLLGSGLAFLGALLTGPLLDGPGVLPTVLGMAAVMGLLSLVALGTPIVRAARYTVMNAPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXJ3</accession>
    <name>A0A7W7WXJ3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphonate transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24137" checksum="42ABEF386A6CDB8C" modified="2021-06-02" version="1">MLALSGMTVRYGDRTVLHGVDVTVAGGELLAVLGANGSGKSTLLRAAASLVPVAAGRVTVDGRPCGRLDLALVFQRIHLVQRRSVLDNVCAGALGRLPLGASLFGFPRDVREEAMACLDRVGLADRAHDRAGSLSGGQQQRVAVARALCQRPRVVLADEPVSALDPAASEQVLALLAELAHVEGLAVLAVLHQPALAARHADRVVGLRDGRVVLDGPPDQPVDALYPTLEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXK2</accession>
    <name>A0A7W7WXK2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="PTHR37981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031160636" evidence="1">
        <location>
            <begin position="27"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="24933" checksum="C69D9F247670525D" modified="2021-06-02" version="1">MAAVLMLALVPAPIAPELVALGDSYAAGTGASRDSCDRSSNAYGALYAKQIHASFVMAACSGATAKSVESQLKSITPAATLVTLTVGGNDIGFADVMTTCTLQSEKSCLKAVDKANKLTAETLPGRLDRLYSKLRATTPAKVVVLGYPHLFEPTGACSLSKAERAALNSAADRLNAVIEARSLAAGFTFGDVRTTFAGHGLCGPSPWINGVKFPVISSYHPNAKGQRLGYLPVLAAARSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXP3</accession>
    <name>A0A7W7WXP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031339264" evidence="1">
        <location>
            <begin position="26"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="317" mass="33571" checksum="CC1905DF644B45C3" modified="2021-06-02" version="1">MSGLLRARVLGIALALVVLSATACSVDFSTVRLTIAAGGTAGEYYALGKALATEWERSPGVARPAVDVTDGAVDNLGRLRTNRAQVGFAQADAAAAIGTAQVMAGEHRLYALARMHDDYFQLVVRADLPVHKLADLRGLRVSTGAAVSGTRFIAELLLDVAGIDPDTDLQVRHLDLESGKNAMVAGTLDAFFWSGGVPTKTITDLAGVVGLRLVDLADVVPRMVERHPVYGWATLPASSYPIPGGAIKTLVVRNFLMVNDTVSDDLAEALTRGLFAAQRTLAEVSPAARSLDTRSAIETTPIPLHPGATRYYRDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ1</accession>
    <name>A0A7W7WXQ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18509" checksum="C40236CADAEE891D" modified="2021-06-02" version="1">MTERDDRVLRGLYDLKNLFGDKWVPAILVALRDGPLRRVEILSTVNSYSIDENWTDKHAVLHDSILARTLKKMREQGLIVRESFDKSFPPEVAYSLTPAVAEVLTLAEPLIEWTRAHPELLSQAQAHSRQSGAETAILDDVVDLDSPAGAGRFHSADRRPRAGGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY03</accession>
    <name>A0A7W7WY03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11768" checksum="7E9135BB7ABEB3FD" modified="2021-06-02" version="1">MFPIIVLALSALLPVRTDACERGEFCAWAAPAYRGTPDRFDLETANPGECVPLPHDARSFANRLSREVTVHQSATCSTEADFTTYPGHGTYVPEAPFVVRALQVWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY32</accession>
    <name>A0A7W7WY32_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="112" mass="11850" checksum="DDC1038C79FCC054" modified="2021-06-02" version="1">MSEPVPEAIAAAVASRGVSRLYELVRARFSGDAAATAALTAAEPADVGSPQVRTLSVLLTQAERADPEFGRELRREFERATSGTTWTVRNRVSGVATNSVQAGHVEGGINFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD5</accession>
    <name>A0A7W7WYD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G3E family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="Cbl_biosynth_CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="209"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="314" mass="33487" checksum="0987D67E49ED8F2D" modified="2021-06-02" version="1">MERVPVVVVAGFLGAGKTTLLNHLLTASRGTRIGVVVNDFGSIGIDAMSVAGQVDSLASLSNGCLCCAVDVSGLDDMLARLDSRVDVIVIEASGLAEPAAMVRMVLASENPRLRYGGLVLLVDAAEFPDDLRRHVPVADLVVLNKVDRVPDVGPALARISALKPGVPAVAVDHGRIDPALLFDRRPRVTHGQLSFDDLADEGEHAHHAYESVEFTAGGMNPTRLMAFLDDRPAGLYRIKGYVAFEVPGHRRRLSVHTVGAFLRFAPAPPGRTELVLIGTGVDAAALRERLAACVEPDPASVDPQSMLEVLRYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ84</accession>
    <name>A0A7W7WZ84_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="457" mass="47974" checksum="A9BC043E45607C91" modified="2021-06-02" version="1">MAGEVEVDRELLARVRSGDDAAFGELFSRHADAVRRFASRHVRDHVEADDLTAEAFFRVLQAIRRGTGPTDHVRTYLLTVARRVAWEWSGRRRDVPVEDEELDRRVEPFPDLTAARAEHTLISRAFTSLPERWRSVLWQVEVEGARPAAVATNFGLSPNAMAALARRAREGLRAAYLQAHLSDDVGPRSCSSVLAKLGTYTAGGVQGAELRKIRTHLRACAKCNALHAELVEVCSTLRAHAAHLAVPVVAASFAAPVLFGKAAWLSGRVKLVLAGAASAVAVGLFGMLAGQYTGAPGPGLVQIGPDGGHLEDVVAVADPSTIGTPETAAEPVPAATGRPGGPVRPAVATTTTAARKPRSEVAAAPATATTPRRDDRHGRVLADPGQTTTTTSDRRDIAAAPGTTVVTSGASSEEPSTPPSAIAPTETGTPTGTPPEPEPEVSVPETPTPTAPPMSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZD9</accession>
    <name>A0A7W7WZD9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="14"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="308" mass="32774" checksum="1BF4AB7C20766127" modified="2021-06-02" version="1">MTKLGTSGLDVSRLSLGGNVFGWTADESDSFAVLDAYTAAGGNFVDTADAYSHWIDGHSGGESEAVVGRWLARRGRRDDVVIATKVGMLPGLDNLKADTIERAAEASLRRLGVDHVDLYYAHRDDPDTPQEESLAAFDRLVRAGKVRYVAASNYTADRLTSALEVSAREGFASFVALQQHYNLVERDYEGELESAVRGGGLSSVPYFGLARGFLTGKYRPGATVDSPRAAAASQYLDDERGPRVLAALDRIAAERNTTVAAVALAWLAARSTVAAPIASARNVAQLTDLLPVLDLELTAAEVDALAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZL1</accession>
    <name>A0A7W7WZL1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein DedA with SNARE-associated domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031168010" evidence="2">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="19923" checksum="50795565667081B1" modified="2021-06-02" version="1">MTTLVVLFVVSVVPLAPTEAVLIACGVLAASGEVPLAAVIAVASVGCFLSDLVNFAVGRGAGMRALRRFSRRTGPRAVVEWTAGRLATRGEPILVAARFVPGGGLIGALLAGSLRLPRRRFAPVALVGATLWSAYTALLGYFGGHLVPDTLTAIVVSFAVATLLGIPVSLLIRKRASPPLKHPELRAQAPSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZR3</accession>
    <name>A0A7W7WZR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IS30 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005331</name>
        <name evidence="6" type="ORF">F4559_006495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase IS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001598">
        <property type="entry name" value="Transposase_IS30_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01043">
        <property type="entry name" value="TRANSPOSASE_IS30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="217"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="375" mass="41800" checksum="CE3BBD29DC7B8BEE" modified="2021-06-02" version="1">MTNKQACGLVGVNPKTGRRWRNGRNASGKNKAASPIQSVASPSAPSRYPCEDDRIHIADRLRERATIRQIAAEPGRSPSTVSREIRRNRHPGNGQYRPHAAQARADARRPRPKERKLAANAELHRAVRDHLGRRLSPEQIAAVLRRDFPDRPEMHVTHETIYQALYVQGRGELRRELARALRTGRTVRKPRRRPGQRQPRFINPMIMISGRPAEAEDRAVPGHWEGDLIIGKDNASAIGTLVERATRYVMLVHLPHGRSAEAVHDALIDTLQALPAHLTRSLTWDQGAEMANHAAFSLATDIPVYFCDPASPWQRGSNENTNGLLRQYFPKGSDLSGHTPEDLVAVAAELNGRPRKTLGWDTPAERLAKLLAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X038</accession>
    <name>A0A7W7X038_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">F4559_006857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="417" mass="42198" checksum="5C6EA451BF70EF96" modified="2021-06-02" version="1">MRVLVIGSGAREHALVLALSRDPAVVALACAPGNAGIAGLAEIRGVDVTDAAAVTSLAVEWRADLVVVGPETPLVAGAADAVRAAGIPCFGPSAAAARIEGSKAFAKDVMAAAGVPTATSEVVDNPARLDAALTHFGPTWVVKDDGLAAGKGVVVTADRATARAHAMTLLDNGHPVLLESFLSGPEVSLFCLVDGANVVPLLPAQDFKRVGDGDSGPNTGGMGAYAPLPWAPDGLVETIVATCVQPVVDELARRDTPFTGLLYAGLALTPTGPQVIEFNCRFGDPETQAVLALLETPLAGLLLAASTGGLGGIADLDWAPGYAVTVVVAAEGYPGRPRTGDVVGGTEADGVLHAGTRRRDDGAVVSTGGRVLAVVGTGDTLADARTSAYDRVKTVHLTGSHHRSDIALRAANGEIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SX81</accession>
    <name>A0A7W7SX81_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxynitrite isomerase</fullName>
            <ecNumber evidence="1">5.99.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ferric nitrobindin</fullName>
            <shortName evidence="1">Nb(III)</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="1">Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.99.-.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="3">
        <location>
            <begin position="56"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="1">
        <location>
            <begin position="63"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22950" checksum="0421B9CBB5C73145" modified="2021-06-02" version="1">MTSDAPVPGSGDAAVQAAASRAATTGSRNLPQFDDLPIPADTANLREGPSLHDACLALLPLVGVWRGEGEVVYPTIDGPYRFGQQVTFAHDGRPFLYYEARSWLLDEQGAVIRPAARETGFWRPQPDDTIEVLLTHNTGIVELYYGKPRTQTSWELGTDAVIRTATAKDVVAAQRLYGIVNNGDLAYVEERAMVGQPLQPHTSAHLRRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXM1</accession>
    <name>A0A7W7SXM1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate isomerase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="28207" checksum="692932C149CACB9A" modified="2021-06-02" version="1">MIPVGLSTAAVWPQPAGAAFEAAAELGYDGVEVMVWADPISQDVRALQRLSNRSGMPVLAVHAPCLLISQRIWSPDPVERLRRSVRAAGELGARTVVLHPPFIWQRRYAEGFAELVAGLEDESGIAIAVENMFPVRRGLGRGRAVQVTAFRPSIDPTDVGHRNYTLDLSHASAAGMDALELYKRMGDGLTHVHLADGSGLPKDEHLVPGRGSQPCAALCESLAGSGFAGQVVLEVNTRRARTAAARRELLAESLRFARRHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXR2</accession>
    <name>A0A7W7SXR2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">F4559_000172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043333">
        <property type="term" value="F:2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25405" checksum="DCDABFD77CD08A5F" modified="2021-06-02" version="1">MARAGLDKNPREVAEMFDGVAQGYDRTNSVMTLGFDRRWREWSRRVLDARAGEKVLDLAAGTAVSTVEFAAQGAWCVAADFSLGMLRGGGHRPVPKVAADALNLPFADDAFDAVTVSFGLRNFNDTEAALKEMSRVVRPGGRLMICEASTPVFGPFRWVYKKHLLKILPFVAKFVSSNPEAYHYLAESMREWPDQRTLAEKIARSGWEDVAWFNLTGGLVALHRATKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXS2</accession>
    <name>A0A7W7SXS2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative repeat protein (TIGR01451 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030936536" evidence="4">
        <location>
            <begin position="34"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2459"/>
            <end position="2485"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="5">
        <location>
            <begin position="500"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="601"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="714"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="929"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1142"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1354"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1566"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1779"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="1997"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="2106"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="6">
        <location>
            <begin position="2202"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="5">
        <location>
            <begin position="2321"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="670"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1947"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2492" mass="250127" checksum="B91B498BCF433B08" modified="2021-06-02" version="1">MARSRFSRRIAAALVSAGVVACSVVVSAPTANAAVVRPFTLNFNEEVYGDFIEVGNTVTTCPSGADPIDPLTAEPHENCDTAQGGTLPNANAGNDAYYMRWYDVDGQGNTVNSTRASITIPPGARVDYARLNWAGDTGTIRLADGTVSPTPGCSTRQFLGGAGTSNLPSGTPESTSVRVTIGGGTQTSYAPQVISRDALANVPNSQPQFYSAYANVTSQFAAAPTGSAQTITVGNIWTPEGFGCFGGWSLVLVYAYDQPDATYAPTKREIFLYDGHVRQSSADPATTTTVSGFRVAANGVRAGLTAFEGDANITGDQFSINGTAVTEPLPGGSDTNYFVSNSNGDTTPSTVNNLSVDAKEFPTTLLPVGSTSATLTFSTSGDTYMATNLVLSVPIPSVSLKKVVTSATTVRPGDTVNYEITVVAPGSSNAVGVSVADPLASGCNRAIGNLTAGTPYVYTCSGPAPDDDFTNVATASGLSDFGDPVTGSGQAAVTVINPELTITKVPDQSTYTTGQTITFTITVTNTGNSALTNVSVADPGVPSCASLPQPLAEGGSFTYTCTATAPLASDTNTATVTGTDALNGPVTASATASAPTPSVVTGRVFSDRNNNGVFESGQGDTGILGVPVRLLGSTTAGVPVDTTVNTIANGTYTFTNVVAGTYSIIESTQPVDFDDGIDTPGTSSSPSSNDRFTLVKAGGVDSTGNNFAERPTSSLSGSVYEDTNGNGSRDGGEPGLYGVAVSLFGTDSAGNSVSFATSTVSDGLYSFQGLRPGSYLLAEETQPASYADGAEEAGTAGGVPNGGDAIININLDPRTDGTGYTFGEYVGATLTGRVFDDGGNGIPNVQINIAGPGAFTTTTGPDGTYSFSNLPPGTYTVTEVQPVGYGDGAETAGTAGGIPGPIATDQITNIVLPSRATASGYTFAEDRGSLAGTVYEDIDNDGVKDIGENGLSGVFVTLTGTDYLGRGVNINTLTAANGTYSFANLVGGSYTLTEVQPGAFADGKETIGNSGGVLSPPNSITTIPLAGGFDATGYLFGEFVAATLSGRVVDDAGTGIAGVVISATNGDGTVTATTIADGTYSFPSLPPGTYTITEAQPTGYGDSTDTVGSAGGTYSAPDSFVGVVLPSATTATGYEFTEDRASLAGTVYEDLNGNGTKQPLEPGIAGVTVALTGLDALSAPVSLTTTTGSDGTFLFEGLLGGTYTLTETTPATYADGIDVPGSAGGTANPPDSIVTIPLGGGVEGDGYLFAEYKGVGLSGSVVNDQGNGIAGVTLTLTGPGGPYTQVTANDGTYAFTNLPPGTYTLVETQPLGYADGTETVGTAGGTATDNQIAGIVIPSGGSATGYQFAEDRGSLSGTVYEDADGSGTKQPLEPGIAGVTVTLTGLDAASNSVSLTTTTGSDGTYTFTGLLGGTYTVTETTPATYTDGIDVVGSAGGTLEPPDSIVSIGLDPGEDATGYLFGDYKGASLAGSVLDDGGNGISGVTVTLTGPGGPFTATTDSSGTFSFTGLAPGTYALSEAQPTGYGDGAETAGTAGGTTSDNLISAIVLTSGTAATGYSFAEDRGSLAGSVFEDQNGNGSRQIGEPGIENVTVTLTGTAVGGASVSLTTTTAVDGGYVFENLVGGTYTVAEPTQPTGYLDGVDTAGTSGGTATPPDSIVNLTLAGGADATGYLFSEYVGTSISGYVLDDAEDGVAGVTITLTGPGGPFTVQTGSDGLWAFLGLAPGTYTVTETQPLGYLDGPDTAGTAGGTPGSDAFTGIVLVSGQVATGYTFTEDRGSIAGIVFDDLDGDGVLDLGEVGIPGVTLTLTGTDDASGAVTLTAVTDSGGNYTFDVIGGTYAITETQPTAFVDGTETAGTAGGEIEPPDSIVAIDLDPGEDATGYLFADLKGASVSGYVLDQNGDGIAGVTITLVGPTAGASVPPPSQTTVTNSEGFFQFLGLKPGSYSLIESQPPGYQDGGDQAGDGGGSAGNDTITDIELSPGQEAQDYEFAEVSGSIAGTVFVDKDDDGVLDPGEVGIEGVQLALLPDGNPPVTLTTTDQDGNFVFTNLAAGEYTIAENQPTGYGQGQVVVGTGGGTVEGDVIEGIVVPTGQAVTEYLFAELAGTISGVVWEDDNGDGELAGEPGRLAGVTIVLQDDEGTEIATTVTDVNGGYSFPNLIAGDYTVVEEQPDGYGSTTPNSVDVTITDDTGATVDFGDQQGSIGDFVWDDTDRDGVQDAGEPGIPDITVELLSQTDEVLKTAITDENGHYRFVGIEAGLYGIHVVAPAGWTFTTPGVGDDATNSDVGRETGLAEPIQITLTGDDITQNANVDAGLVPVAVDLAVELTVDPETSWVGGWVTFAGRVGNAGTVTIAGSRTVITVPVQLGIVEITGDGWTCGVAGQVVTCTNDAVLEPGHVTPFVLVKTAVMSTFTDVAATAAVTLINGEADENPLNDTATVTVSATEEQPPPPPVQPGPPLAWTGVSGVLPLLFLGLGILVVGAVTVRMTTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY17</accession>
    <name>A0A7W7SY17_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="127" mass="13368" checksum="BBBEFDE885CBA37F" modified="2021-06-02" version="1">MADWDHLRRKAQEAASLAYAPYSGLHVGAAALCSDGRVVTGCNVENASYGLGLCAECTMAGQLRLTGGGRFVAVACRSGDGELLMPCGRCRQLLYELGGPECLVDTPHGIRPMTEVLPDAFGPEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU2</accession>
    <name>A0A7W7SYU2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="13309" checksum="6735C6A8BA6ADAE7" modified="2021-06-02" version="1">MLSSAPHDLDKQTEQNRHERIAAIKKAIADLDARKKRLIRTLEVTGDDDEVPDQEFIQDNKNRHTEIKAERAKPATELETLEEQVNDQQNPYLLRLLPVGACDGTVKRAALAHFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ22</accession>
    <name>A0A7W7SZ22_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="307"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="764" mass="84519" checksum="F4EF162D8DDA4CCA" modified="2021-06-02" version="1">MSALFDLPSSPPASRSARLLDDLNPAQRRAVEHAGAPLLVVAGAGSGKTRVLTRRIAHLLAERDVHPGEIMAITFTNKAAAEMKERVADLVGARARAMWVSTFHSMCVRVMRREAKTLGMSSNFSIYDSDDTRRLITLVARDLDLDPKRYPARTLAIHISNLKNELVDFETAADRAANDLERRVAEVYASYQRRLTESNSLDFDDLIMRTVELLQNHPDVAEHYHRRFRHVLVDEYQDTNHAQYTLVRELVGTGVDGVPPAELCVVGDADQSIYAFRGATIRNIEEFERDYPQATTILLEQNYRSTQNILTAANAVISRNPGRRDKRLWSDLGEGEKIVGYVADNEHDEAAFVANEIDRLVDSGDATNGEIAVFYRTNNQSRVFEEIFIRLGLPYRVVGGVRFYERREVRDALAYLRTLANPEDTVSLRRILNVPKRGIGDRAEACVSTYAERERISFASALRAAVEGRVPLLNPRSQRAIAGFVELLDELGALVERGDDVADVLEAVLDRTAYRAELEASEDPQDHTRVENLNELVTVAREFGDLGAATEDGPAEGTLAAFLERVALVADADSVPDAESDGVVTLMTLHTAKGLEYPVVFSTGWEDGVFPHLRALGDPTELAEERRLAYVGITRAQQRLYLSRALVRSAWGQPAANPGSRFLDEIPAELLDWRRVEPRRTAPSAPTSWGRRSESPRPAPSNANWKDTPALSLEVGDRVSHDKYGLGRVVAVDGSGPRATATIDFGGAGTVRLMLIGGVPLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ69</accession>
    <name>A0A7W7SZ69_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Maltose alpha-D-glucosyltransferase</fullName>
            <ecNumber evidence="3">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="7">
        <location>
            <begin position="57"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="602" mass="68850" checksum="4CDA1F0D8856BA90" modified="2021-06-02" version="1">MHEDPRPDAALGLAGVPHTGEAVGADGLLVEPQAEDFRSATSAPADKDWFKGAVFYEVLVRAFSDSNGDGTGDLRGLASRLDYLEWLGVDCLWLPPFYASPLRDGGYDISDFRAVLPEFGTVEDFVYLLDEAHRRGIRVITDLVLNHTSDAHPWFQASRQDPTGPYGDYYVWSDDDQRYADARIIFVDTETSNWTYDPVRGQFYWHRFFSHQPDLNYESADVQEAMLDVLRFWLDLGIDGFRLDAVPYLFEQEGTNCENLPRTHDFLKRCRKVVDDEYPGRILLAEANQWPSDVVEYFGDPAVGGDECHMAFHFPLMPRIFMAVRRESRFPISEILAQTPEIPADTQWGIFLRNHDELTLEMVTDEERDYMYAEYAKDPRMKANIGIRRRLAPLLENDRNQQELFTAMLLSLPGSPVLYYGDEIGMGDNIWLGDRDAVRTPMQWTPDRNAGFSACDPGRIYLPVIMDPVYGYQGLNVEAQLNNQSSLLQWTRRMIEVRKQHHAFAEGDFTDLGGSNPSVLAYRRRWRRPDGHEDVVLCVNNLSRFPQPVELDLSEHRECRPYELTGGVRFPAIGELSYLLTLPGHGFYWFQLVAAGDDGEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ81</accession>
    <name>A0A7W7SZ81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="93"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="30743" checksum="6CF88C71BC5ABFCF" modified="2021-06-02" version="1">MSAHPWMPTSPCGDGCVDHTTATVGGVRAGLRALAGVLVLLCGIPLLPVLLLTRGRVRRTVLRSWFRTLLRGFGVRLEVVGPALFQATPGRGVLVVANHVSWLDELALDAVQPIRIVAKRDIRSWPVLGPLITACGTVYLDRERLSLLPGTVAELAATLRDGAAVGIHAEGTTWCGHASGRYRPALFQSALDAGVPVRPVVLRYRQDGATSTRPAFIGSDTLVDSMRRVLRARGLVVEVHVLDEIAPGRAADRRGLAALVQQESERAVAGVLPLPVHPRLDFERTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG0</accession>
    <name>A0A7W7SZG0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_000536</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031155505" evidence="15">
        <location>
            <begin position="33"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4963177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26517" checksum="828740507AA50AD1" modified="2021-06-02" version="1">MKRSAVRPSPLFLGLLAATVAGALLTLPDSTAARTGGTVLFVLAGWAVSLCLHEFGHALTAYRGGDYAVRAKGYLTLDIRHYTDPVLSIVMPLVLLAIGGIPLPGGAVWINHHALRSKRVESMVSLAGPLSNLALGTLLTVSVAVFDPPAGLAGALSYLALLQILAFVLNILPIPGLDGWGVFEPYMSYSARQFGAKARQWAPFVLFAVLIGLPGIARLFFDLADTVFELVGGDQWAAGDGQRTFMFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM4</accession>
    <name>A0A7W7SZM4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15619" checksum="17744E79F27D31E2" modified="2021-06-02" version="1">MTASVTNQDALQLVVAVHRLIRSLRQAAPVKRLQPTQLLVLSELSTQGPMRIGEIAVRALCSQPTATTVVTGLESGGLVRREPDPADGRATIVELTGAGRETIASLAHGEAELLSDRLSRLTEAELESLRLATSLLRRLADPHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN1</accession>
    <name>A0A7W7SZN1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase in catechol pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="27301" checksum="2405C389D6791761" modified="2021-06-02" version="1">MRIARIAQPDGLAFAAIEGEGDDLTAVEIADDPFSDPKFTGRKWPLADVRLLAPFLPPKIVCVGRNYAAHAAELGNEVPDNPLIFLKPNTAVVGPNADVKLPAVSERVDFEGELAVVIGVGGRDIPAARAWQSVLGYTIANDVTARDLQKTDGQWTRAKGFDTFCPLGPWVETSFDPRDVAIRTIVDGEVKQDSRTSLLVHDIPTLIEYISGIMTLRPLDVILTGTPAGVGPLSPGQSVSVTIEGLGTLTNPVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZU9</accession>
    <name>A0A7W7SZU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016672">
        <property type="entry name" value="Polyketide_Synth_CurC_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016602">
        <property type="entry name" value="CurC_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="14969" checksum="D8D4EDFB9C9BB1F8" modified="2021-06-02" version="1">MNAPRKINATAVEPNVRRGGEIRVTLSPRTVGACSGFGGVLDLAPGDHVTEHYHPYSEEFLHVVTGELRLWLDGDPVDLGADDSLLVPIGVRHRLVNVGTAPAHVVFHLSPLAPRPELGHVDTEAPRDESRPNVDVGGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A2</accession>
    <name>A0A7W7T0A2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">trmD</name>
        <name evidence="17" type="ORF">F4559_001300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4963941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="246" mass="27003" checksum="35B1D9751C534DC5" modified="2021-06-02" version="1">MRIDVVTIFPEYLQPLRAALLGKAIDKGLLDVAVHDLRDWTHDVHKAVDDSPYGGGPGMVMKPQVWGEALDEVCAGDVPPRLIVPTPAGRPFTQELAHEYAAESRLVFACGRYEGIDQRVVDDASRRMRVDEVSIGDYVLVGGEVAVLVMVEAVVRLLPGVLGNPDSAAQDSFSDGLLEGPSYTRPEVWRDLAVPDVLRSGNHRAIDRWRRDEALRRTAARRPDLLGALPAEAFDKHDRALLEGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D6</accession>
    <name>A0A7W7T0D6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">F4559_000314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4962955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="11119" checksum="3F38AF5677E803A1" modified="2021-06-02" version="1">MADTRRLPGPNADLWDWQMRGSCRGMDSAFFFHPDGERGPARARREARAKAVCLSCPVLEMCRRHALAVQEPYGIWGGLSESERDTIIKARKRQLTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V3</accession>
    <name>A0A7W7T0V3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11089" checksum="3C0C1C1BF9FA1DB0" modified="2021-06-02" version="1">MTFQVDVEQLRAHAANVAEIQARFAAVKAASAHITQDGQAYGVLCEWISGVLEGRHAEQDELIAYQEETLDIVVTTLLVGSDDYETVDADNASLVRAAGEGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T169</accession>
    <name>A0A7W7T169_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15438" checksum="D6AD7ED4DE7030EF" modified="2021-06-02" version="1">MSAQRSRQVDQFGWLVSNFADRVPGVAHAVVISVDGLLLTASNGLPDDRAEQLSAIAAGVASLTESASRCFDGGGVLRSVVEMQYGIMLLMSIRDGSCLAVLAAPDSDVGQVAYEMTVVVDQVGQLLTPELRAQLSGAKRMMARPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1B1</accession>
    <name>A0A7W7T1B1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthase</fullName>
            <ecNumber evidence="14">2.7.8.41</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_001810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.41" evidence="14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4964451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="21310" checksum="9AFC986DBEF4A4B7" modified="2021-06-02" version="1">MPHDPADRWLTIPNALSVLRLLGVPLFLYLLLGPRADGWALVVLVAAGLSDWLDGKIARWLDQMSRLGALLDPAADRLYILATLVAFVVRDIVPLWVAVVLVAREIVVGACLPLLRVRGYGPFEVSYLGKGATFNLLYAFPLLLLAQGGSTAALIARPVAYAFMTWGGALYLWSGLLYVYQAVLALRRRPGVAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F1</accession>
    <name>A0A7W7T1F1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030810209" evidence="1">
        <location>
            <begin position="25"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22573" checksum="D093119FAEE17FA8" modified="2021-06-02" version="1">MLNFAAAAALALSTIVFPPGGAPGSVPPPDHITIDVVTVNGSGCPAGTAAIAVSPDNKAFTVSYSAFLAQVGVGSQPTDFRKNCQINLRVNVPQGFTYGIAQADYRGFAHLEKGATGIERANYYFQGMSPTTYRTHSYSGAFSEDWQATDTTELAAIVYHPCGEKRNFNINTELRVNAGTSNTATTTSFMSMDSTDGSFDTKYHFAWKRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1L7</accession>
    <name>A0A7W7T1L7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="30316" checksum="20650532AE4DDED9" modified="2021-06-02" version="1">MSDIRRVGVVGAGLMGSGIAEVCARAGLDVVVADVSAEATEAGRGRIAASLGKAVRGGKLGTEDRDAALERLRFTTDLTDLRDRDLVVEAVAENEQVKIEVFRTLDAVVADPRAILASNTSSIPIAKLATATGRPGQVVGVHFFNPVPVLKLVELVPSLLTDERTVTRAEEFATGTLGKQVIRSQDRAGFVVNALLIPYLLAAVRMLESGFASAADIDAGMVLGCAHPMGPLRLADLIGLDTTRAIAESLYAEFKEPLYAPPPLLLRMVDAGLLGRKSGRGFHDYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R9</accession>
    <name>A0A7W7T1R9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein YeaQ/YmgE (Transglycosylase-associated protein family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="247" mass="24951" checksum="2878F75D46761767" modified="2021-06-02" version="1">MSDYKNLLLRGVGAGGVSGLLAGLVGFFVVEVPIKAALAVEEARSAAEPVEEGGHEHGELVSRGVQEYGGVLAAVIVGIAIGALFATAYAASRRWLPAASPYARSVALSAAAFGAAALLPAVKYPANPPGVGDPETVGVRTLTYLLLIAAGLLVAYGAGYLATRLGHLAAPVRSAAVAVAVVVAVVVILVAFPATPDSVPADIPAGLLWEFRLKSLAETATLWLGLGVVFGLLVDPAVRRAKVASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z4</accession>
    <name>A0A7W7T1Z4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Siderophore synthetase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="3">
        <location>
            <begin position="200"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="4">
        <location>
            <begin position="441"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="628" mass="67292" checksum="7577C5062E1BBC7C" modified="2021-06-02" version="1">MTPDPRDHPPATGFPGRPPLPAGHDVGRPPTAPGTDGTDASGHDAGRGLGDPTSGGPGAHDHHEGRVRPRDRAPGRPLLDAGDPLCGPPGQAAAHAHLEALLRCWTRERDVPVHDRVRVEVRGGVLAADVRYASPTGRHRFGVVTLDGRPVDPVLAAALVAARLGGDVADLVERVAESVRRVEVFVEHRRREPVGPADRFLEAEQRLLLGHLHHPAPKSRDGISAADNARFSPELRGSFPLFWFSAAEEVVSHGAVDGPDTPSLLAALAGRTPEPGRVLVPAHPWQARDLVHRPRIASLISRGLLEPLGESGPAWSATSSLRTVYRTGSPVMLKLSLGLRITNSRRESTATELRRGSEIHRLLDTGFAAGTLAAHPAFDVVRDPAWLAVDEGGDVTGLDVALRKVPSDIGDSRCLAGLVAPRPGIGRTLLGELVLRLDAARWVADYTDHVLVPMLRLYAETGIGLEAHQQNTLVRVDRAGRVVGGRYRDNQGYYLAASHLPRVLGHLGVHESTLAVVDDAIVDDRLTYYLLRNQALAVIGCLGEEGLADERDLLAVMAARLEHAVPALARAGPDGDRLAKRWLSAESLPCKANLLTRLAGIDEVLAPLDNQSVYFAAPNPLREGRCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T212</accession>
    <name>A0A7W7T212_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="219"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="43084" checksum="0B4367D9BE51622E" modified="2021-06-02" version="1">MTSLWRQGNFRNLWLAQTLSLVGTQVTVLAFPLVALLLLDASALEVSLLYAIEFVPVLLLGLPAGALVERLSKRLVLLVSDAARAVALLLVPVAWVWDFLSLPLVFAVAFVVGLGTLFFDVAQGSYLPGLVDERQLADANAKIEVSRSASQLAGPTAGGVLVQFLTAPVAVLLDAVSYVVSFVLLLFVKGRDVVTPPEERQGLRQEIGEGLRFVLSHRLLRPLAWCDALANLAFAAVLALQVVYAADDLKLGATAIGVVLAVGNAGGLVGALVCGKLGERFPPGPLLLGSIALFTIGAAILPLSTGAVSFGVGLFVVYLGVVVYNVVGTTLRQLATPERLLGRMNATLRFIEWGTLPLGAAVGGLLVAPLGLRGVLWLAAGVCALSILPPLLSPVRALMENPSADEPEAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T265</accession>
    <name>A0A7W7T265_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16697" checksum="73529642769EA7BE" modified="2021-06-02" version="1">MDSSDDLTLLFTALSAACDVDVRRRMAAAGHHEVRTIHGYVFRHLLDGPIRITDLADLLGMTAQGASKVVADMERAGYASRSPDPHDSRVRLVSLTRRGHEAVRISRRARADVTGELLATLGPEGDKLITALRRLSDHTDALPDLLARRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2B3</accession>
    <name>A0A7W7T2B3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0225 protein F4559_002290</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0225 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00612">
        <property type="entry name" value="UPF0225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023006">
        <property type="entry name" value="UPF0225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13916" checksum="0D02F0FA47D5A050" modified="2021-06-02" version="1">MSPRACPCGTGEPYAECCGLYHSGTRTAPTAEALMRSRFSAFAVGDVPYLLASWHPSTRPRDLDLDPRQRFTTLEIVGRSGGTALHTAGTVEFRAHYRVAGTSDVLHENSRFVREDGRWLYVSPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C4</accession>
    <name>A0A7W7T2C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017393">
        <property type="entry name" value="MTase_SAV2177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30949" checksum="6849BAF616397E0B" modified="2021-06-02" version="1">MSYYPDWLPDGTDPNVPSVARTYDYMLGGAHNLAADRAMAEQIIKVMPTIKQLVRLNRAFLRRAVTHLVDSGVRQFLDIGSGIPTVGNVHEIVQRLDPECRVVYVDKDPVAIAQSKLILHGNERTAAVQADLREPDDLLARPEVTGLLDFDRPIGLLLLLVVHFVPRDHDVLAMMARYRERLVPDSYLVISHATDDERPETMRRTAEAVRDARSRDNLVYRTHDEVTELFAGFDIVEPGVTGFGLWRPDGVGSIADNPDDNMQIRVGVARKPPGPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2F8</accession>
    <name>A0A7W7T2F8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-methylcytosine-specific restriction endonuclease McrBC regulatory subunit McrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019292">
        <property type="entry name" value="McrC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10117">
        <property type="entry name" value="McrBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17809" checksum="20148A9B9DBCCA4D" modified="2021-06-02" version="1">MLATDDTGAVLDAEFEIEQDGDSSVCEDFVTVALTEAWRSRPGRTRPKPPTLLDAERGIAMAPDVVHLVDEIPRIVVDAKYKLATGTGRYPNADHYQALAYATALEVAHTWLVYAGTAELARTHHVLNSPVTITTYALDLDVEPPELLAQVQRLADSAWDAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H0</accession>
    <name>A0A7W7T2H0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Quinolinate synthase</fullName>
            <ecNumber evidence="3">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="339" mass="36293" checksum="43470355B034B501" modified="2021-06-02" version="1">MVATAYVERTTDGAYDGIAPDAAWRDEVLELARRRDAVILAHNYQLPEIQDIAHHTGDSLALSRIAAASDASTIVFCGVHFMAETAKILAPHKTVLIPDERAGCSLADSITGEQLRAWKAEHPGAVVVSYVNTTAEVKAETDICCTSSNAVDVVASIPADREVLFLPDQFLGAHVKRETGRENLHIWAGECHVHAGINGPELAERAAANPDADLFIHPECGCATSALYLAGEGTVPAEKVKILSTGDMITAARATSATSVLVATEIGMLHQLRRAAPEIDFRAVNDRASCRYMKMITPTALLRCLRDGLDEVHVDADTARRAKGAVQRMIEIGKPGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2P4</accession>
    <name>A0A7W7T2P4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="29" mass="3198" checksum="96BBF9B6391A0201" modified="2021-06-02" version="1">MGAVPRPIVLTKRRHVDLVRVAAQGCPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2V2</accession>
    <name>A0A7W7T2V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter (DMT)-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="29344" checksum="EE858EFC954E14FC" modified="2021-06-02" version="1">MDVKAVGAVVVTMVLWASAFVGIRYAGAHYEPGSLALGRLLVGAIALAAIAFAKGVKVPPRAAWPGIVGSGVFWFALYMVALNWGERHTDAGTAALIIGIGPILAAIIAGVVLKERLAARLVLGLAIAFGGAAAVGLSGGTGSSTTSGVLLCLVAAAGYAVGVVLQKPALAHASALQATTFGCVIGAVACLPFAGQLLDDVADAPASATISVVYLGLLPTALAFYTWAYALSRTTTGKLGATTYAVPAIVVLLSWLLLDEVPGLIAVLGGALCLVGVAVSRTKPARTRQERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2V3</accession>
    <name>A0A7W7T2V3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choice-of-anchor A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026588">
        <property type="entry name" value="Choice_anch_A"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04215">
        <property type="entry name" value="choice_anch_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031406275" evidence="3">
        <location>
            <begin position="26"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="413" mass="41146" checksum="1E317B905C3B8847" modified="2021-06-02" version="1">MIRTFALAGASALLVLAATPGTGVAAPLPGGLGPCVGDDCPDTYPPVNNGAFTGRDDGVTVFVGGDFDAGVGAVESEGRIVVGGDFSLEKTTGGTIYNIGIAGVGSRVPPSDGADFLVTGGDVTIATGQTLLADGGVVRHAGTLTGTTTGTAVQDDDAFLPYAPLAAELQAASTCYAAATPTGTVVNEGFRTLFTGDDTSSLQVFTVDADVTGPAGAQQEIVFEDVPAGATVLVNVLGTDRSIVTSSGDLADVDPLNGLRERLLWNFPTATSVLIGGLGQFQGSTLVGDPTSLTTVTAPGHAGRFFTTGDLAHGGGTNSGQEFHAYAFDGDLPGCAAQPTTTTTTTQPAPTTAEQTTTTTCATTGPCGPDSGGGGRRPDLAVTGPDRVAWLVPIGALLVLVGATSLLVARRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T339</accession>
    <name>A0A7W7T339_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="75" mass="8614" checksum="FB25516956C6DF08" modified="2021-06-02" version="1">MTFDPDRWLKDPTFDNVPFGWAPTTCLGVGIGIAQLILWFRLLTTRYRVTTNRPSRMTMLASPTPHDFRGTITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G8</accession>
    <name>A0A7W7T3G8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="2">
        <location>
            <begin position="221"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="419" mass="45317" checksum="998D8C4539397BBA" modified="2021-06-02" version="1">MPSVTAAQYGDNRRMAEAGGRTLTGDAVEMLPGAGYTDVPAQRATSAARGLTFTRRRQWIFDVAAVVVAALDVSLRVVPESQPYQWVLSIIAVAAVAFRRRFPFLVVLVTFPGFFAGWAQLAAMIALGTLARRKLLTTPTYVGAAMVWMSRFFLWPVDEFLKLDWRTHVHDAIYGCIVAGMPIAIGLLAHAREQLSARIAELAESRERERMLHAHAVRADERARLAREMHDVVSHQVSLIAMQAGALRMAAADPNAKQVAGTIRTLSTRTLEELRQLVSVLRTTNGDDSPQPRIEDLPQLVAGAGFPVRLAVEVDSLPAPVSGAVYRTVQEALTNVRKHADGAATSVRIAAVGEELRVEVHNEPSAHPDRRRLPGGGHGLVGLRERAALLNGVFEAGPSEDGGFSVRVTFPLGCAAHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N2</accession>
    <name>A0A7W7T3N2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="32348" checksum="7F3A3464993242F5" modified="2021-06-02" version="1">MRRLAAVVLTGAVVLTGCSTEENPADPLQIAASLEPARPAASPEVSGVPAGTVVPVGAARDVVVLDGVAAVAVTDPPSVTFLGTTPRAVPLPGPAERLVVVTGAIEAAVPSAGVVVTVRADGSTSSREVAGGPVDVAVVEGRTLVARRDARQVDVDGRSVGGFSSPDRVVAAGSHAVVLDRPRSALFDLDLSATGPGAGLRAGEGATNAVVDRFGRVFVVDTRGGELLAFSTAPLIMRLRYPVPGAPYGLAYDGARDLLWVTLTDRNEVVGYDVSGAEPVEKHRYPTVRQPDAVAVDGKTGHVHVVSGTGQGMQVIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U2</accession>
    <name>A0A7W7T3U2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="50013" checksum="399DE1A10CEF964A" modified="2021-06-02" version="1">MGDVIGTKIPGRLDRLPWSRWHWRILLGLGTVWVLDGLEVTIVGAMAARLVEPDAGAGLTAATVGVAAACYVAGACVGALVFGRLTDTFGRKKLFLVTLGVYVVATVATAFSFAPWFFFLARFVTGAGIGGEYAAINSAVDELIPARLRGRIDLVVNGTYWAGAAAGSALALVLLDTDLLPTGLGWRIAFALGAVLGLLILVVRRHVPESPRWLFIHGRAAEAERLVDDVEREVRAETGAELSEVDKKIEIRQRGSVPLREIAVTAFRDYPKRSVLGLALFVGQAFLYNGITFNLGTLFADYYHVASGVIPLFLVVYAVGNLLGPLVLGHFFDTVGRKPMIAATYLGSALATIPLTWAFVTGTGGAGLFLALLVVTFFLASAGASSAYLTVSEIFPMETRALAIAFFYAVGTALGGIVGPLLFGSLIESGDVGRVAFGFGLSAVVMALGGVAALLFGVKAERASLEDVARPLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W3</accession>
    <name>A0A7W7T3W3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031556318" evidence="4">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="256" mass="26004" checksum="D7C7E7DEF6CECCDC" modified="2021-06-02" version="1">MTVRHLFAALLAALTVTACSTPTTPPATTADKPTGEITVFAAASLTEVFTALGKEFEAANPGTTVRFSFAGSSALAKQLKDGAPADVFASAAPATLAEVRDAGVITAAPTTFARNRLRIAVPKGNPGRVTGLADFADESRRIALCAAQVPCGAAAGKAFAAAGVTPKPDTLEQDVKAVLTKVRLGEVDAALVYRTDVAATTEVEGVDFPEADASVTEYPIAPVATAPNARGADAFIGFVRSDRGRAALTGAGFDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z3</accession>
    <name>A0A7W7T3Z3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl transferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_003455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1631"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2639"/>
            <end position="2714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="1665"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4966096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="2790" mass="288530" checksum="744987EBF93389EE" modified="2021-06-02" version="1">MSSDDRIRQLLLKVTAELTDTRERLDAVRHEPIAIIGTACRFPGGVSSPEDLWRLVAAGGDAVGPFPADRGWDLDALYDADPDRPGTSYTRHGAFLDDIAGFDAGFFGISPREALATDPQHRLLLETTWEALERAGIDPHSVRGKDVGVFAGVNGQDYAARLPATPASVDGYLAVGTAASVASGRISYTFGFSGPAVTIDTACSSSLVALHLAAKSLRSGESSLAVVGGVTVMASPSSFVEFSRQRGLSGDGRCRAFSDEADGTGWGEGVGVLLLERLSDARANGHRVLAVVRGSAVNQDGASNGLTAPNGPAQESVIRAALADARLDPSDVDVVEAHGTGTRLGDPIEANALITAYGRGRAADRPLWLGSVKSNIGHTQAAAGAAGIIKIVEALRHGVLPRTLHVDRPTTHVDWSDGVLRLLEHELPWPGGETPRRAGVSAFGVSGTNAHVIIEEAPAEEAVPGRVPGVEPAVGAQRPVGVPVERSPEAVAAGTERPSIGERFPDRAAEAADVPDGVPVVPWVLSGYSPEAVVAQAERLSGVVGDPADVGWSLATRRATLGERAVVLGVDRAALDDGLRALASGAASASVVRGVAGGSVAFLFTGQGAQRVGMGRGLYAAYPVFAGAFDAAVAELDRESGVSVADVVFGTGDGSLDDTLYTQAGVFAVEVALFRLFESWGVRPDFVTGHSIGELAAAHVAGVWSLADAARIVAARGRLMRALPTGGAMAALAAPEAEVRDLLAGLSDVDIAAVNGPNAVVVSGAEESVLAVAAHVAGSGRRTKRLTVSHAFHSPLVEPVLAEFRAVVAGVRASAPTIPVVSAVTGRPVSAELADPDYWVRHARHAVRFADAVTHLVAAGVDTFVEIGPDAVLTALAADSAPDAVLVPALRKDRPESLAVVTALATAHVRGRPVDWTAVFPGARAVDLPTYAFQRERFWLDVERAPADAAGFGLVDADHPLLGATVALAEDGGLVLTGRLSRHTHPWLADHVVGSTVLLPGTAFVELAVRAGDEVGADVLEDLVVEAPLVLGDRAVRVQVAVGPPDGTGRSVSVHSRAEDEDGWTRHASGRLGSSSATGPDRLDVWPPAAVPVDVDSLYPVLADAGLAYGPAFQGVQALWKDGNTLYAEVSTEDTQGFAVHPALLDAALHPAAYDTLATTPSGRNRLPFAWRGVRVHATGATSLRVRLTVTGDDELSLLAADAQGEPVVTVDSLRSRLVEVGAAGPRDALFTVDWVPSGPAEAGTDRVVLLDAPEPTGDPVADAHTATAAVLAGLRAHLASDDERTLVVRVRDGLAYAPVVGLVRAAQTERPGRVVLLDTDSGLVPALGDEPQLRVRDGQVSVPRLVRAAPRAPGRAWDPDGTVVITGGLGALGAEFAHHVVTRHGARNLLLLGRRGAATPGVDALVTTLTALGARVEVAAVDVADRAVLAAVLAGRTLTAVLHTAGVVDDGVIDSLTPERAAAVLRPKVNAAWHLHELTLDQDLAAFVLFSSVAGVLGSGGQGAYAAANTFLDALAAHRVALGLPARSLAWGMWERASGISGHLTAADHARNARAGIRRIDTAGGLALFDLALRVDDPLVVPAPLDLAAVRRAGTVPSLLRGLVRPARRVATAGQPAGRFAGLDREGRSAGLLELVRAEVAAVLGTTPAAIGPARAFRDLGLDSLTSVELRNRLDAATGLRLPATLAFDHPTPAALVEHLLAELFPTAETTPDVVAPVARVDEPIAIVGMACRLPGGVDSPDALWELVRDGRDAVTPFPDNRGWDLDGLYDPDPDHAGTSYTRHGGFLHDADGFDAEFFGISPREALATDPQQRLLLETAWEAVEGAGIDPTTLRGSRTGVFAGVMYHDYAPRVGEAPAQLEGFVANGSAGSVASGRVAYTFGFEGPAVTVDTACSSSLVALHLAVQSLRTGESDLALAGGVAIMSTPAVFVEFSRQRGLAADGRCKAYAGAADGTGWAEGVGLLLVERLSDARRNGHRVLGIVRGTAVNQDGASNGLTAPNGPAQQRVIRQALANAGLRPSEVDLVEGHGTGTTLGDPIEAQALLATYGRDRTGVPLYLGSLKSNIGHTQAAAGAAGIIKVVQALRHDLLPRTLHVDEPTPHVDWSSGGVELLTEARPWPETGRPRRAGVSSFGVSGTNAHVIVEQGDPEPAPAPADPALPWVLSARTPDALAAWGERLTGLDGSAAAALPGRTAFAERAVVLGDHAAGLAALTAGRSAPNLVTGTAGTPGRTVFVFPGQGSQWAGMGVELLDTAPAFAARFAECAAALHPLVDWSPQDVLRGASGAPGLDRVDVVQPVLWAVLVSLAALWEAHGVSPDAVVGHSQGEIAAATVAGALSLVDGARVVVLRSRAITALSGRGGMASLALPVDVVTERIAPYADRVSVAAVNGPAAVVVAGEPDALAAIVAGATEDGHRARTIAVDYASHSAHVEPIRDEILAALAGIEPRESAVPLFSTVTADWIDTTGLDAEYWYTNLRRTVRLAEAVRGLADQGHDVFVEISPHPVLTASVQDTLEAAGVDRPVVAGSLRREEGGLDRFRASVAELWVRGVPVDWTAVTGGEEAASGPVDREPVTGGRIVGVRPGLPTYPFQRSRYWLEQAAGDGRARADLPTADPEAGTRLVRSLAGLDPDERAAAVLDLVRGETATVLGHGDPSAVDDTRPLRELGLDSLTAVDLRNRLGAATGLDLPATLVFDHPTPADLAAFLVSELGGGDVDRFPNADASVDYLEAVFAAGDHPDLAARLRALLDRLGTPAGGDGLDFGAASDDELFAFMDNNFEEPAGHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P9</accession>
    <name>A0A7W7T4P9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="35162" checksum="7BF594D184DB598F" modified="2021-06-02" version="1">MTTRVLYTPDDRELDLDRLSDADHDLITSLHDLIGPDDRVLRCLAAAEEHDALYVHRVADKYFLAHFAAGGHAPHPVVRIGDEHKRQTEYWYRAGEDAGYPSDTGYATGGRVVDVAIHGPRRTAVEVQRSRITVRTARRRTTGSHRAGWSSLWFTAADRVPSWFHHVPSVGCNHLPWDDLPPRGRATATGLRRVTVARCDVHSFDRCPAGHRRHCGDDHAKLEVWRGLTLDRVAGLVPSGQVVPLRTPDGLVYFVPQEDVRVYRDLTGYAADYRPEDEPVPARECVTCGNPLFWLRPGRTRCERCDPVMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R0</accession>
    <name>A0A7W7T4R0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_003928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4966569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1219" mass="134996" checksum="1DC174FEF72D8E5F" modified="2021-06-02" version="1">MSTGLSEALVNTRRFFTRAEVSSDLRTLHIKGGREADAFYRDRWSHDKVVRSTHGVNCTGSCSWKVYVKDGIITWESQQTDYPSVGPDRPEYEPRGCPRGAAFSWYTYSPTRVRYPYVRGVLLEMFREAKARTGDPVRAWAEIVEDPDKARRYKAARGKGGLVRATWDEAAELVAAAHVHTIRAYGPDRVAGFSPIPAMSMVSHASGARFVSLLGGTMLSFYDWYADLPVASPQMFGDQTDVPESGDWWDAGYLIMWGSNIPVTRTPDAHWMTEARYRGQKVVAVAPDYADNVKFADEWLPARPGTDGALAMAMGHVVLREFFVDRQVPYFTDYVKRYTDLPFLVRLDEHGDVYRPGKFLTAEDLGHDEENAAFKTVLIDAETGQPVVPNGSLGHRYGERGEGRWNLDLGDVDPLLSADGSGEPVTVALARFDAADGSQGELRRGVPVRRVGGHLVTTVFDLMLAQYGVHRPGLPGEWPTGYDDASQPGTPAWQEPITGVPAQAAARIGREFADNAERTRGRSMIIMGAGTNHWFHSDTIYRAFLALTTLTGCQGVNGGGWAHYVGQEKCRPITGWAQLAFGLDWSRPPRQMIQTAFWYLHTDQFRYDRFGAGALAGAVTGGKLAGSTTADLIAQSARLGWMPSYPTFDRNPLDLADEATEAGLPVADHVVAELKSGRLRFACEDPDDPRNFPRVLSVWRANLLGSSAKGNEYFLRHLLGTDDSLRAEETPPSLRPKDVVWHEKAPVGKLDLLLSLDFRMTGTTLFSDVVLPAATWYEKHDLNTTDMHPFVHSFNPAIAPPWQTRTDWVAFRTIAEAFSRLAATHLGVRTDVVATPLLHDTPDELATPHGRVRDWKRGECEPIPGVTMPRLTAVERDYGAIAAKMGALGPLADSLGATTKGITFRVEKEIEYLARKNGTVRGGPADGRPSLARDLDACETILALSGTTNGHLAVQGFETLEKRTGTKLADLAAEHEGKRITFADTQAAPVPVITSPEWSGSESGGRRYSPFTINVERLKPWHTLTGRQHFYLDHDWMAELGERLPVFRPPLDMTALFDEPRVGEHGPRGLSVRYLTPHSKWSIHSEYQDNLFMLSLSRGGQTIWMSTVDAEKIGVADNDWIEAVNRNGVVVARAIVSHRMPEGTVYMHHAQDRLIDVPRAETSGKRGGIHNSLTRLLVKPSHLIGGYAQLSFAFNYLGPTGNQRDEVTVIRRRSQEVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4S1</accession>
    <name>A0A7W7T4S1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008900">
        <property type="entry name" value="Zot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05707">
        <property type="entry name" value="Zot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="56"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="742"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1128" mass="120886" checksum="F265935F750FD787" modified="2021-06-02" version="1">MNEEERHALASVQFNWAVTPDDIWSPLDHHVDGLHQRAAEDITHAVAAAARKADANPTGIVLRGERGVGKTHLLGWLRQRVQQEGGAFFLLKLLDEHSFWAGAVHGVVGGLLTNDQLGRMLDKLAERTGHNHESRLRLRGTIPVARADVDGLIDRLYDIDPRVAVECQDTLRALVLYRAKGQPSEVGHGFLVLADGIDEADREAWGFRSRTRPAQLVLNDLSRIFALTGPVVMAVDQIDSVLTRPATGVDEVELADRLADGLMRLREETRRTILVVACIPGSWDLIANRGVNSAADRFRVLDLRTAMPSASVATAIVERHLAGLYGEIGFTPPYPTWPVLRSAFGADGIAHYTPRRLLQRVDDHVRRCLARDEVAELADFDAGEVDAAPTPVVPVDLGVLDERFARLCAAADVTAPLDHEWEDKLVPALLNAALRCYVVEQGDHGHDLSIDALPGGKPALHARLRRTLDEATEDEVHWSFRAIAHTHPNAVLTRLRSAYLEAGLRDGGNRHLVVLREAPFSGGPRTAQAVGEFQAAGGVVLPFADEDLRVFAALRTLIDESPAGLRAWLRARRPAGSSDLFTRVFPASTRRPSKARADLFQPEVPPAPKLSATSTGTNLRPVAVESADAHPEPAHPEPAHPAESTGFHPVPAEATGTGFRPVDPGAPLPRREPAKPMGFAPIPAESTGTRLTPVTPEPTAVEPAGSDGHRVDLADAGAPEPVLTFGASVATGTPFTVPLSALRKHVAVFAGSGSGKTVLLRRLIEEAALAGVSSIVIDTNNDLARLGDEWPAEPAGWGPGDADRAARYHADTEVVVWTPCRAAGRPLVLNPFPDFGGVLDDPDEFRMSVDASVSGLMPRTGLVGRRIDTGRAVLTQALTWYARRGGTDLAGFVEALTDLPDGVGTVRDATRLAADMADGLHAAMINDPVFGGVGDHVDPGVLLTPTPGRRARVSVISCVGLATDDQRRTFVNHLQLALFAWIRRHPAGDRPLGGLLVLDEAQTFVPSRGVTASTESSLRLATQARKYGLGLVYATQAPKALHNMVTGNAATQLFGRLNAAIQIQTALDLARAKGGRIDDISRLPAGVFHASTEGTGFVKVRAPMCLSHHPAGALTESEVVDRAATLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V9</accession>
    <name>A0A7W7T4V9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_003982</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="9">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4966623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="270" mass="28931" checksum="9BDED188168B7DAA" modified="2021-06-02" version="1">MTAVAERVTAPTRRHTARPFAIVRHSLALAKRSLIKTMRTPEQLLDVTLQPLIFVVMFVYLLGGAVAGDTHAYLQLLLPAIMVQTTAFGGMATGVNLNTDIEKGVFDRFRSLPIARSAPLIGSVLGDLIRYVVAIASLLVFGTLLGFRVETGFVAAVAACLLTILFAFSLSWAFVMIGMLMRNPGGVQGVAFIVLFPLTFGTSMIAPAASMPGWLRAWVDVNPVTHAMNAARGLMVGGPVATSVLWTLAWSAIFLAVFAPLAVAAYRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y4</accession>
    <name>A0A7W7T4Y4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4097 and DUF4098 domain-containing protein YvlB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="50"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="281" mass="29781" checksum="C9911FA9186FD9B3" modified="2021-06-02" version="1">MPIFDSPDPISVNLELVQADIRLVASDRVDTLVEVRPFDPDLALDVTAAEQTRVEFTGGTLTVRSARTWTFVSRVGTIEVTLEVPTGSRVQATGAVCEFRSGGRLGECRIKAASGAISVEDTGPLTAVSANGAVSAGFVDGDLHVDAGSGDVRVRRAGGEVRIKAGNGDVSLGEAERDVRVRSSNGDVFVDRAHAGVDAKTSNGDVRIAEVIRGDVVVETASGELEVGFRDGTAAWLDLHTYSGRVRNTLTDTEGPTGTDEKARVRARTYSGDIVIRRSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T570</accession>
    <name>A0A7W7T570_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="561" mass="62130" checksum="7271D0E68C8995E7" modified="2021-06-02" version="1">MHHHNSAGRVKEYDFSTLPVAEPMQRSLATLFAARCIPRRWTVHASSTMYWRQLEMFTAFLSRQMRPPRDVDELTASLIERWREHALATVGGYTTFTAVTSLLRGDLRLQTAPVADTLSRRAPRPRSGIQSYSEAEFDRIKLAARRMFRAALLRIEHNAAHLHRWQAGEFVEDSRDWALGEALDVLARTGDLIRHPGHRTRGGQGIVYKYRKAFGGMAAAVTWQRLFLSSMEATALGVLLLAEFGWNLSVIDRAAIPRALPDPGEDGRPTYRIPIEKRRCGAGHFYETRNVTDDGAASPGRLITHALAATRFARAIVADRSPETDLLVVWRTHVAGRERADGDRQPPVGPFHFGVHRDAGARWARTVGLRGSPFQRGRQTVNALDRREPGQNSQDTHDRHYVLVDKRVRAEAVAIVAAGAEEATEHARRAVLVAELQDVPDPGDVETATADCADIEHSPYPAPGGGSGGRCGASFLMCLGCVNARIHPGHHPRLAHLHDAVGNLRSVLAPTVWEVDWGATHARLDDLKTKLGTTGWTRAKAQLTDTDRELIDLMLTGDLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5D6</accession>
    <name>A0A7W7T5D6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylacetate-CoA ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="437" mass="47983" checksum="94B25B493659400F" modified="2021-06-02" version="1">MLINSLDRLHTLQLARAEIRAGHRATSSHSFYQQKLQSVWARARNTDAYRRLGEFSPENFARLPATGKDRLKSDPGAFLAAAIGEAVKYYETTGTTGSPTPTPRLAEDIIWNTTSVAEAWRGLFTPDERVLVMMPSDIVPVADLIVGVVEYLGFPHTRAYPFATGISDWDRVIGLWRTLRPTTVFVAPGVALQFSRLLKQRGLLDELGASVDRLMLLGEVSTAPFRRRLGHWWGARAFDASYGSTETGTLAASCARDRLHLLTTTNYFELATDDGVVPLPASGSGRLVVTPLNLHARVLLRLDTGDEVEVGGECGCGDGSPVIRVSGRSSDALRVRGATLTVRGVEEVVYGATEATGYLMETDTTGDFARLILERDVRWDRSGERGMAGQLQDASRDLLGLQWDEVLFVNQLPATTKSGASQKSWKRSNFRVVESVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Q7</accession>
    <name>A0A7W7T5Q7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="28128" checksum="4FCD1AA94C98DF35" modified="2021-06-02" version="1">MLWNPGAVARMLDVSPTTLRTWDRRYGLGPSTRSAGNHRRYSADDVARLRRMIALTRDGVSPAVAAAAVKEVLSAPEFAEAASRLDVPLMTSTAARLIAERGVVAAWEDVLAPFLAALGERIAEQGAGVEIEHLASGAILAALATRPEVTGRPCALLACAPDEQHSLPLHALAAALTELGHATRNLGARVPARALLDTVNLLTPPVIVLWAHDRTRAEAVPLPDLLRSGHRVLLGGAGWAMEPTGTRKPASLNEAVTTIVELNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R1</accession>
    <name>A0A7W7T5R1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S12 methylthiotransferase accessory factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="52"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="352" mass="36802" checksum="D85EC74FF4167C59" modified="2021-06-02" version="1">MIPHDETLNRIGPVLTAVGVTRLADVTWLDEVGIPCWQAVRPTARTLSVSQGKGLTPEAAAVSAAMEAIEVWHAENLPAGPEVGSVRSMRDRLGYPVTALRTTGRTCVNDDLVLDWVPATRLSDGGTGFVPTAALRLDGTVVEEWAPPLFEVTSNGLASGPTRVDAVLHGLYEVIERDALAGAESDRVGLDLGGVDEVAAGLVERFERAGVAVAAYLVPSPVAVPCVEVRVSSEEFPVDFRGSAAHLDGSVALHRALTEAAQSRVAAIAGTREDLLGDLFGDSWTPAGPAVAGTAALPAPTHHATATAVEVLAARVTAHTGHSPLVVEHTRDEFAIPVVRVVCPGLDCPHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T8</accession>
    <name>A0A7W7T5T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13601" checksum="4F192432A8706A03" modified="2021-06-02" version="1">MLSSKGEDFATFWAERHLCTLTTLRPDGTPHVVPVGVTLDVAAGVARVITSRGSRKARNVVATGRAVVCQVDGARWSTLEGTAVLRTDAASVADAEERYARRYRTPRPNPERAVIEIVVTRALGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T641</accession>
    <name>A0A7W7T641_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="153" mass="17140" checksum="DD560D9BDE0FC2A4" modified="2021-06-02" version="1">MRTERLTLDPVTMADLAEFVALDRVLRPDADPTRSAGYLAAFVETWRTGDLGYWTIRLRREVIGFGGVQPKKRSGPPAWNLYYRLHPDHRGHGYATEMAWAAVAAARETRPEWPVLIETRPDNAPSIALAGRLGMTREPDHEGYAVFVLPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T646</accession>
    <name>A0A7W7T646_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="86" mass="9450" checksum="9801BCD7BC102328" modified="2021-06-02" version="1">MVRQPLTQADHDRGEHLGRLLRQARGDRSMTDTAHAAGISVETLRKIERGRIPTPAFFTVAALAAAVGLSLDDLNRHLNDRRQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T667</accession>
    <name>A0A7W7T667_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14085" checksum="0F2BF103066F5CB0" modified="2021-06-02" version="1">MGNPFDSSLRHLKPARPSAVRRHGLSAVAGAALAAFHWAYFELPRSWFADETGFGWAMLGVMIAPLTWIATWYGLYKAGVARPGWTVLLGLALTWCVVWFLARNDAMPYWAVIPVTAVAFLVAALFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T675</accession>
    <name>A0A7W7T675_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MbtH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005153">
        <property type="entry name" value="MbtH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038020">
        <property type="entry name" value="MbtH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037407">
        <property type="entry name" value="MLP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38444">
        <property type="entry name" value="PTHR38444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03621">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00923">
        <property type="entry name" value="MbtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160582">
        <property type="entry name" value="SSF160582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MbtH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7740" checksum="56AFDAFD6BDABB88" modified="2021-06-02" version="1">MSEQERYLVVVNEEEQYSIWPADRELPAGWTAEGFGGEKQACLDHIAQVWTDMRPASLRRRMADARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6E3</accession>
    <name>A0A7W7T6E3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC-like DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035418">
        <property type="entry name" value="AraC-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14525">
        <property type="entry name" value="AraC_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="213"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="38061" checksum="850A9829228B94D0" modified="2021-06-02" version="1">MFDSAEFPADQRVDAWREAVESALVTADVRVLDPAVFTARLHVTSLGIAQIAASSYASLAARRTARMIRKSDPECYQLVLVESGRQRIRQLDRCEHLRPGELVLYDSSTSSEVFVGDQPTLAGAVVLQFPKRLLPIPEARVARLVAVPLPAATGVGDLFAGFLRGLAVGRHDRTERDTLRLGHIAVDLASAVLAHHLDDATAPPHSPGHVLYLNVASFIDRNLHRVDLVPATIAAAHGISVRYLHRIFQQHHETAVAAHVRARRLDHCRRDLADPGLRHLTIAAIATRWGFGRPSDFGRAFRNDVGMSPGDYRAWAGVHGKRSTGRGTGVNRPTDRSTSGVRTPGGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6H9</accession>
    <name>A0A7W7T6H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="29507" checksum="07727CE6C4E4E1B8" modified="2021-06-02" version="1">MKEQREVISALRGVGVLAGVRWAYVSATTRTLEQYSEADGHDAAWLGNTRFTLFRDRLDRVFACERYAVHSGNDDADLDVLYDQLSSQDIFSMPQLDSGLVRRSNLNGSPGWVCGERRFLLASCDYGKLDSLPWPRRGPTKQWVAGQRNPEPQQPSLFDDEEIGGLEALLAAQRDLDLDTYVVSHTLDRLGGQIELVFGRPRLNTGGGQAWYWYENLLTDPPAGGGRRTDDTPLPTGPNTTPDAPVRLRRSAEERRDDRRSGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J8</accession>
    <name>A0A7W7T6J8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding IclR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IclR-ED" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="58" mass="6030" checksum="FF0F9CA386360DDD" modified="2021-06-02" version="1">MEKAVLRVRVAAPVRGPNGDVVAAVSVVVPIETRTDTVLPAVRAGGRAISRALGRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M3</accession>
    <name>A0A7W7T6M3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Broad specificity phosphatase PhoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="25486" checksum="01F5041149D64EAF" modified="2021-06-02" version="1">MRVDFGWIGLIRHAESTANVVGARAEADGSETIDLPERDADVPLSDRGLEQASALGRWFGAQPRAQWPDVVVCSPYRRAIDTARLALPEHPLTIVDERVRDRELGVLDLLTRHGVARRFPDEVVRERRLGKFYHRPPGGESWADVALRLRSLLGDLDRRFPGRRLLLVGHEVTALLLRYLLECVPERDLLAYARNRIVPNASLTSWTPAGDRYALEHEHATAHLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7C7</accession>
    <name>A0A7W7T7C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 6'-N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.82</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.82" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047663">
        <property type="term" value="F:aminoglycoside 6'-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="175" mass="19724" checksum="95251CCDBD264CD7" modified="2021-06-02" version="1">MRLTTDRLVVRHFTPEDAAAFAAWRSDPEVARYQSWDAPYPEAKAVEFVRELLASDPDAPGWYQYAVEADGLVVGDVGVCLHENGMQAEIGYSVARAHQRRGYATEAVHGVLGFLFEERGLHRVSAECDAHNTPSAKLLTRLGFRLEGRRPENTWTKGAWRDDLLFGLLARDWHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7N3</accession>
    <name>A0A7W7T7N3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="73"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="181"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="389" mass="43254" checksum="E96413E7E881E337" modified="2021-06-02" version="1">MGRPSLPVGTHGRIKVTAKSNGGYVARTKFRDFDGVTRPVERTGQTRTSATNALMEALRDRTSAAGGLVTADTKFRDVADLWLEDVRSSVDAGEMSPNSLDLYERQLRNYVRPALGELSIREVNTPRVDALLRGVRKRRGASTTKTVRSVVSGIMGLAARHGATSVNPTRETKRITADRKRSVRALTREERQRWLAQLESDRQAVRKDLPDLTRWMMATGVRIGEALAVSWDETDLDAGTVDIDWTIVRVRGVGLRRMPPKTESGERTLRLPPFAVAMLRRRRRLAALDREIGPGTAVPVFPDALGGWRDPNNTRRDLRSARGTEGFAWVTSHVFRKTCATILDEAKLTPREIADQLGHSRPSMTQDVYLGRKVVNPATAEALERELGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Q5</accession>
    <name>A0A7W7T7Q5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_005496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="24"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="595" mass="65903" checksum="E42DC87C82D60624" modified="2021-06-02" version="1">MTAVAPQPIATRPFGTRQAVKGSFLLRMFRTTDHKQIGILYLVTSFAFFMVGGAMAMLMRTELARPGMQFLSQEQFNQLFTMHGTVMLLLYATPIVFGFANFVLPLQIGSPDVAFPRLNAFSYWLYLFGGLITLSGFLTPGGAADFGWFAYTPLSNAIHSPGVGADLWIAGLAVGGLGTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSVLVLLAFPILTAALFGLLADRHLGAHVFDPANGGVILWQHLFWFFGHPEVYIVALPFFGIVSEIFPVFSRKPIFGYNGLVYATLGIAALSVAVWAHHMYATGAVLLPFFAFMTFLIAVPTGIKFFNWIGTMWKGQLTFETPMLFSLGFIVTFLFGGLSGVLLAAPAIDFHVSDTYFVVAHFHYVLYGTIVFATFAGIYFWFPKITGRMLDEPLGKLHFWTTFLGFHGTFLVQHWLGNEGMPRRYADYLPSDGFTTLNTISTIGAYVLGASTLPFIWNVFKSYRYGETVHVDDPWGFGNSLEWATSCPPPRHNFTELPRIRSARPAFELHYPHMIERIHAEAHVTFTGKAIPHEQAHSTPFEAAAHAVQSGTASEKTEGDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7S3</accession>
    <name>A0A7W7T7S3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smoa_sbd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041654">
        <property type="entry name" value="StyA_sbd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17885">
        <property type="entry name" value="Smoa_sbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smoa_sbd" evidence="1">
        <location>
            <begin position="132"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="420" mass="45926" checksum="EF11C961258B9752" modified="2021-06-02" version="1">MVLSAALLRAGWQVSLYSDRTAEDHLADRGRPTACLFGDQVEYEAELGLPTWSQASPFTRIHLDLYTPAGPVAFSVDAPLDKPALAVDQRLKFSSGLAELAARGAEVVIGAVSLEDLDDLAASHDLVVVTVGHKAFQGLFPRDDARSTHTEPQRKLFMVNVAGYDLDAHPVHRQGVFSFLPGTVEVFWIPFWDKDVGESRSIVVEITPGGKADRFDDVTTADEGLAVFKEVVAELLPGELPFVAPTRATSPVTFIKGAIVPVVRHPVAELPSGRHVLGLGDAVVLNDPLSGQGANNATRMAKFFAERLTAHDGAITAPWLREQFDAFWEKGRYATEFTNGLLAPLRDHQKNVLLAASHDEEIGARLWSGFNDPSSLFPWFFDETEAHRYLAERQVGRGTLLRYKLGVAARVIGGRLSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T801</accession>
    <name>A0A7W7T801_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="214" mass="23182" checksum="DCB07C9D8EABF72F" modified="2021-06-02" version="1">MRVVIAEDSVLLRVGVERLLADEGIETVAAVEDGEALLAAVDEHRPDLALVDVRMPPTFTDEGLRAAIEARRRHPDLTVLVLSQYVEERYAVELLAGGANGVGYLLKERVADVAEFVAAVRRVADGGTSIDHEVITQLMVRSKRNPVDSLTQREREVLGLMAQGLSNTAIAASLVVSDGAVEKHVGNIFAKLGLEPSTSEHRRVRAVLAYLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T831</accession>
    <name>A0A7W7T831_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="144"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="355" mass="37384" checksum="4E3FB90DD0A5F82E" modified="2021-06-02" version="1">MIRRFTQGEPLSERPGHSLVGVIRMPDSVQSPVRAIMKRVIGALAALCAAVLIVYLDRDGYRDVNGDGLSLLDSIYYATVSLSTTGYGDITPASSSARLVNVLVITPLRVLFLIVLVGTTLEVLTERSRQALRIQKWRSKVRDHVVVVGYGTKGRSAVSALLGDGVDPGSIVVVDTSQESLDAASAIGLVTVHGSGTSNDVLQVAGAPRARAIVVAANRDDTAVLVTLTARELAKKAQIVASVRERENEHLLRQSGADSVVVSSETAGRLLGMATATPSVVAMVEDLLTPDAGLAIAERDVEASEIGGSPRHLPDIVLGVVRGGKLYRVDAAEADAVEAGDRLLYVKKVTPPDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T871</accession>
    <name>A0A7W7T871_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliW</name>
        <name evidence="4" type="ORF">F4559_005707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="13954" checksum="0F7DFDBA082F378D" modified="2021-06-02" version="1">MSDADTAPVIEFSVPMPGFPEHRRFLLVRTTEDGLLFSLRSVDDPELRFLVVPPAPFFPDYAPEIGAQAVEQLGTVDVSDLLVLLVVTVGESASSATANLLAPIVVDQRTRRAVQVVLTAGDLRAPLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A3</accession>
    <name>A0A7W7T8A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="453" mass="49384" checksum="E5D2C87DA09F8FE9" modified="2021-06-02" version="1">MSGFSSRRVGVEWRAALWAVRHPVVVGVPGAVAASAVEFGPTVTGLALGGLAAGVGAWWRAHPDSFDAVAAPRLRAVRRRWLSRYMGGLWRDVLLDCDLAPTHRRTGLPRVPRVLRVRSFSPSVDTVFVRMVPGQTARQWEDAAERLASALDAERVGVERVKPQVLGVIVQHRETFSGVLEAPEMPWDSEAVDLGAVGFGETEYGDAWCEPVAGQHVFGVGATGAGKASLVWSPLRAMAPLIRDGLVRLWVCDPKRMELVRSEPIAYRYAAEPGDCVELVRGYVADLEDTERRLASAGRRKFAVSRETPLNVLVLDELGALLGFGDYALVKEMRRLLSYVGTQGRATGHSMWGFTQEPTKDVVPVRDLFTVRVCLRVTSAGHVDMALGDGARLRGALADEIPNDPATAGIGYVLRQRSRLPMRVRASYVDDSEIDEFVRFVTAGRPGGLRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8V8</accession>
    <name>A0A7W7T8V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="247"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="486" mass="54972" checksum="CD52D0B3A12A8CB5" modified="2021-06-02" version="1">MSGRWVDPAPFEGARPRVPWWMLMPGRLRWLAVLVFLVWSLVVAVVRLVFVVLRYPIAVVVLAGSAWVWWRFGLSPLVLALLSLVAALELWWGLWRRSFLRWFWLRVVTEWRRATVYVPRWRSVVRLSGLVGRDRGREYRPRLRRVRSEGWRDRVRVRMVPGQAPDAWEARREGLAHSFGARSCRVRVLRPRVVELDFVHSDPLARPVPVPALGGVEVDFRRVVVGVTESGRPWRLRLLGAQVLVVGVPGAGKGSVLWSLVWFLAPAVRAGLVRLVGIDPKGGMELGQCPEAFDRVVYDNGPDAVALLEAVAAQVRERASRYRGVRRLWTRSAGEPFTVLVVDELADLVAYQPDKGLRERAVRAVQTITSQGRAPGYAVVGLVQDPRKEVVGFRHLFSTRVALRLDEPGQVDMVLGDGVRERGAAAHEIGEDTPGVAWVKQDDRREPERARAFHVTDGDLVELRDYLTYGRVHEQPDDGDQWQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F0</accession>
    <name>A0A7W7T9F0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030781211" evidence="3">
        <location>
            <begin position="30"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="89"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="561" mass="61102" checksum="3BBDFE145904EC17" modified="2021-06-02" version="1">MVHSRTARRRWTAAIGLTGVAALALSACAQSERGTDSSSGSGKTGGTFTFGAAGAPKLFDPFYATDGETFRVARQMFDGLTTFKPGTAEPVGQLAEKWSSSSDGLTWTFNLRKGVKFHDGTEFNAAAVCANFERWYNQKGAGQSDAVSQYYGDNFGGFSDGAKPSLYKSCSAKDAATAEIVLTSSTSKFPDILGLPAFSMQSPDALKKYDADNVQAQGESFVFPAYATEHPTGSGPFKFSKYDKANGTVELVRNDDYWGEKAKVDKLVFKIIPDETARKQALQSGDIDGFDFPNAADWDSLKKDGFNVQIRPAFNVLYLGINQKNNPKLRDLKVRQALIYGINREQLVKSQLPEGAKVATQFIPETVGGYAKDVTEYKYDEAKAKALLAEAGASDLTLKFYWPSEVTRPYMPNPKDIFGAISADLQKLGIKIEVTTKPWNGGYLTDVDQGVPDLFLLGWTGDTGSADNWIGTFFGNPANRFNTGANTWGTDLATALKKADAEPDRDKRFKLYEDLNKKIMTEYLPAIPVSHSPPALVTKSSVKGIVPSPLTDERFYSVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB54</accession>
    <name>A0A7W7TB54_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding Lrp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16924" checksum="5D5617A37B215044" modified="2021-06-02" version="1">MDEVDSAILRELQTDARITNRDLAARVGIAPSTCLERVRVLRNRGVLKGFHAEVDLKALNRSVEALVAVRVRPLSRAEVAEFERTLIALPEVLTVYTTSGVDDFVVHVAVRDMEHMHTFVVDRLGGRREVVGYRSSMIYLSTKTPAITELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBI5</accession>
    <name>A0A7W7TBI5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N,N'-diacetylchitobiose transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="31495" checksum="6A8C051D861EEBF2" modified="2021-06-02" version="1">MNARKGDGRIAYALLAPALLVLVGLMGYPIYQLVLISLFDYGQEQVSGGAPLIFLGVGNYATLLSDAKFWSVLGQTLGFAAVCVVGTLLVGATLAVLATRVRTWARTVLFLAALGAWATPAVAGSTIWLFLFDANFGFVNELLGTTGFSWTFDKWTAFGLVAAQVIWCSFPFVMVTLYAGIKAIPGEVIEAAALDGASTFRTARSVILPLLRPILIVVTIQSIIWDFKVFTQIYVMTNGGGIAGRNLVLNVYAYQQAFAASEYGLGAAIGVVMTALLLVVTLGYLRALRKSGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TC76</accession>
    <name>A0A7W7TC76_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024659">
        <property type="entry name" value="Phage_coat_Gp5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11651">
        <property type="entry name" value="P22_CoatProtein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="292" mass="31821" checksum="1745B315E6FD67C8" modified="2021-06-02" version="1">MPNQLLTVDVIAREAIATLYEQTVMSGLVHRDYEGDFTGNSGDTITIRKPATFVVNEFNRTNGIQLQNATEGSTSLVLNKIPDVSFAVTSEDWSMRITDFSEQFLTPAMEAINQYTDRLVLGLRADITQSVTYDPAAAHVSDVLIDAGKVLNDANVPTSQRRAVHSTTLAALLQKDPLFVEADKVGDDGTALREASLGRKRGFDNVLTQNVKDDVSVAFRREAFALVTRTLPLPRGIGAGQGAVVTYKGLGLRVIYGYDMTRKEDVVSIDCLMGVKTLDPKRAVLIKRKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCV7</accession>
    <name>A0A7W7TCV7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator/heat shock protein HspR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="141" mass="15506" checksum="B4DF7FB0512D194C" modified="2021-06-02" version="1">MTFPFPPGTDEDTPFFVISVAAQLSGLHAQTLRSYDRMGLVSPGRTSGGGRRYSMRDIVVLREVQRLSQEEGVNLAGIKRIIELENEVGALRAHVQELTEQLASALAAADAAAASVHASYRRDLVPVRHETALVVWKPRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT90</accession>
    <name>A0A7W7WT90_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="28845" checksum="229B3A38B65298DB" modified="2021-06-02" version="1">MIGALLAQIEEPVQQAVDTVTTGEAVAFWVLGPLALAGALGMLFARNAVHSALWLVLTMLSLGVLYMVQQAPFLGFVQIIVYTGAIMMLFLFVLMLVGRDSSDSVVEVLRGQRFAATVLGIGFAGLVVGSLARALTDVKPVGLAQPNAEGGNVASIGEQLFTTYLFPFELTSALLITAAVGAMVLAFTSKSGETKKTQRELVEERFRGDRVGSLPGPGVFATANSVATPALLPDGSVAQESLSALIETTAKETLADDVAEVAGTGHQPDAHALKGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM6</accession>
    <name>A0A7W7WTM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="423" mass="44141" checksum="BFFDE276A827E1BC" modified="2021-06-02" version="1">MGSPGVRNGVRRVALAASAGNAVELYDFLLYGTASALVFDKLFFPSVDPLLGTFLALATFGAGFLARPLGGVVIGHFGDRVGRRSMLVLTLTVTGLCTAAIGLLPTYDSIGVAAPILLLCLRLVQGFFLGGEQGGAALMVVEHAPPNRTGWYGGWTFLGSPLGLLLANAAVAGAVVVSGDAFGDWGWRLPFLFSLVLVGVGLYVRLGVAESPQFRRMRAERGTERLPVVVVLRDSWRRVLLGAGVNAGFNAFIFVVATFVISYGTKQLALPRSVMLDASLLGAFAQVLAILGFARLSDRVGRLPVMLGGAVFLALYAFPLFWLLETRVTGLVVLAVVIGFAGAAAVFGPMPAYYSELFGTGVRYTGVSLSYQLGAVLGGGLSPAAAQWLLAAGGSWSVSLYLVVGAAVSTACLLVVGETRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTP6</accession>
    <name>A0A7W7WTP6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed RNA polymerase specialized sigma24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="70" mass="7561" checksum="A2B1ECEC46B76649" modified="2021-06-02" version="1">MTEATALASAAGDRDPRVGLRAVSALRRLLEQLEAVQVRNARLSGWSWQEIAAELGVSRQAVHKKHGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU35</accession>
    <name>A0A7W7WU35_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="59" mass="6630" checksum="7A2D099B0FFC919A" modified="2021-06-02" version="1">MSKDEAPDWRVSSWSASESNCVEIHRDLGAVRDSKNRMGPELRFRPGALAAFVQGVRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUB0</accession>
    <name>A0A7W7WUB0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="199"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="586" mass="64358" checksum="31ED2AB387A9FBEF" modified="2021-06-02" version="1">MARPPGRTRGSVDTLPSGALRVRVNAGSHPTTGKPVVLTETVPPGPDAEVLAEAARLRLLDRATRPIPTATVDHLVEHYLARTRLEQTTRESYEGNHTKHIHPLIGRLPADKVDALTLDTFYAELERCRDHCTGPVLHHTPDKHTCDLRCRPHTCKPLAAWTVRKIHYLLRGAYRLAIRHRLADHNPVTEADPPAPPAPDPQPPTPDELAAILDEATRHDPDFATLIWLAAVTGDRRGENCGLRLHHYDRARRRLTVRRAIAEGRTGTWEKDTKTHQRRHIALDADTCAVLDQHIDRARTRALAGGVDLSSDAFLFTTTPDGSRPLTPSSVTQKYRRLVTKLGLDTSLHKLRHYSATELITSGVDIRTVAGRLGHGGGGTTTLKTYAAWVNEADQRAAQTLLDRMPTRIPTTPPTTPIPTPPAESPYEVVAAREHIRITTTENLPTGTPAPTVKQIATRYGVSVGTAHRALTLLNQQGLVTGARRGVRATILRTPDDTTEPPPPAVPTPPDPTPPTAPRPLRLVITHNNTEIATLVTITDPTDYTELRRLLLQALHRRGHPPTTSGEFELTVQDPDTATTIVTFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUG0</accession>
    <name>A0A7W7WUG0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="31524" checksum="8B9034424EE94F90" modified="2021-06-02" version="1">MREVFVSTVQDAMRTDPRIAVVLAEISRDVFAPHERVINVGIREQALVGVGSGLALSGLRPVVHTYAPFLVERPFEQIKLDFGHQDVGGLLVSIGASYDAPVWGRTHQAPGDVALFDTLPGWTVVVPGHPDEVGPLVSDALSRDDRIYIRLSLRSNTRTVPVTPAATRIRSGRRGVIVSVGTTLDTVLAATADLDVTVLYATTVRPFDAAGLRAAVSGVDHADVLLVEPYLEGTSAHEVTVALSDVPHRLRSLGVRRDAELRAYGTADDHDAAHELDVVGIAAAAHRLFDHPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUN5</accession>
    <name>A0A7W7WUN5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="22039" checksum="92F7778FBAF379FB" modified="2021-06-02" version="1">MAERRDAARNRAAIRSAAARLIRERGPDGFVIEDVAAAAGVGKGTVFRHFTDRAGLVRAVVELASREWRTESDALFDDADMAPDEKLVTFVGRLFDHVVDSLPLVRALELSEFDQSGCDDNTVLVHRRISDLIAQVNPDADARYIAHALLALLRGDVLHHQLVRSGLDLGRVRAGVIALARSVLVGDLERAGRDATMPGLSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUT2</accession>
    <name>A0A7W7WUT2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10729" checksum="AAD54439F725B23D" modified="2021-06-02" version="1">MSPSRFGDPDDEAVTADELLVDEPAVEVPEQRDQPPVPHVCDGGWVDPDADRPVPCPVCQPWLAVTVRVGICPPRVRPARQESPAVPSSVPVDARGDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV30</accession>
    <name>A0A7W7WV30_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DMATS type aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="Aro_prenylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="Aro_prenylTrfase_DMATS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="33273" checksum="97574B0268174D5A" modified="2021-06-02" version="1">MEFSAAFAAGEAPVVRTIVETTAIAPSRRTNTAAALECLDRLRDRPELGLDLRRFDSVRDLFLPERPEQDFTLWYSLVFRGGTAPGVKVYLNPEVRGVDAAEDLVREGLARTGFGDAFRILRERAVTRPGLDRYSFFALDLTDPARARVKVYISHHAAGVDEVTRAAEAARGVDVDRLPDFCLLTGGHTARFDGRPLISSYTFLEGDTDRPSGYSLYVPIRDYVEDDAEARERVLAVMAKYDMDPAPFDDALAAVARRRLADGVGLIAHVSLRMGRPRPGITVYLSAEAHAVAPPRPVRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV64</accession>
    <name>A0A7W7WV64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome accessory factor A</fullName>
            <ecNumber evidence="3">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019941">
        <property type="term" value="P:modification-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022366">
        <property type="entry name" value="Pup_deamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004347">
        <property type="entry name" value="Pup_ligase/deamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42307">
        <property type="entry name" value="PTHR42307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03136">
        <property type="entry name" value="Pup_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018077">
        <property type="entry name" value="UCP018077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03688">
        <property type="entry name" value="pupylate_PafA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR018077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="498" mass="54835" checksum="5A8DBCC12F829CCD" modified="2021-06-02" version="1">MRRIMGTEVEYGIAVPGDATANPVLTSTQVVLAYAAAADIPRARRARWDYEVESPLRDARGFDLGHPGGHPGGDGDVEDLGAANVILTNGARLYVDHAHPEYSAPEVTNARDAVIWDKAGERVMEEAALRAATVPGQPRLQLYKNNVDGKGASYGTHENYLMKRATPFTAVIAGLTPFFVSRQVVTGSGRVGIGPAGEEAGFQLSQRSDYIEVEVGLETTLKRGIINTRDEPHADADKYRRLHVIIGDANLAEYSTYLKVGTTSLVLDMIEAGLRFDDLRLLEPVRSVHRISHDPTLKTRVELAGGRKFTGLDLQYAYYERAAEFVDREGVGDREVLRVWGEVLDALSRDPQECADRLDWVAKLRLLEGYRARDGLAWGSPRLSLVDLQYSDVRLDKGLYNRLVARGSMKRLVSEEEVRAAILAPPEDTRAYFRGRCLERYPAAVAAASWDSVIFDLGRESLVRIPTLEPLRGTKAHVGALLEASDTAEQLVEALTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVD7</accession>
    <name>A0A7W7WVD7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040701">
        <property type="entry name" value="Bact_RF_family2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18844">
        <property type="entry name" value="baeRF_family2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="32397" checksum="C0BB7F9D5FA5F388" modified="2021-06-02" version="1">MRTAGLRHVIGAEGPFASVYYDIGEHGDLRWTAIRDQLAGAGAERALLVLADATIGHDVVAPREHAGRALVVTPGRVLVDRFLPRAPAGYVARYGDLPYLLPLVDLAEPVVPHVVVRVDPHGADLCGIDPTGRPVAVGACRPGRELDARELADVAREAATLVDRLRASLLVLSGPAEMRRGLRIALPPPYHRLVVETDEPAERVAGKPADRDEVVRRFRDESTALSGRAVHGLDDVVAALAADRVDTVLLGDALVGGRLVDGVRADEWLPLLAVEQGVDVVLAGDSLRLHEDVGALVASRAADSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVY7</accession>
    <name>A0A7W7WVY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="27158" checksum="16B20406C532959D" modified="2021-06-02" version="1">MATEHSGTGDPARTLALLWRTAEPVARKGRPDLGVDRITAVAVEIADTDGLAALSMRRVAERLGVGTMSLYTYVPGKGELVDVMVDLVNGGTPRPDDVPGGWRGRLTRIAHDNWDLHLRHPWLLQVAGHRAVLGPNVAAKYDYELRALDGIGLTDVEMDAVLSLVLGHVRTAARQHVETALTAQRTGLTDGQWWEAAAPILARVLDPARFPTAARVGQAAGEAHDAPYDASHALGFGLDRILDGVAALIASRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW17</accession>
    <name>A0A7W7WW17_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP:flavonoid glycosyltransferase YjiC (YdhE family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="DUF1205"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="DUF1205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1205" evidence="2">
        <location>
            <begin position="167"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="373" mass="39488" checksum="E680EBBFA581490F" modified="2021-06-02" version="1">MRVLVIPLPYPTHLMAMVPLCWALRTSGHEVLIACPPEVRATAHAAGLTTVDVPGHEEAPATTIRLRFPLPAFGERYTDAGRDLWRATADSVVRDSLDRLADYRAVAESWRPSLLLVDVCALVGRVLGGLLDVPVAAHRWGVDPTAGPFTERARELLDLPEPTLVLDPCPPGLQAVDAPPGRPVQFVPYNGSGTVPGWSTPPPGVRRICVCMGRMVLDTTGPAPLRRAVAAATAVPGTQTVVAVSREHRRWLADLPADVLVAESVPLNLFLDTCAAVVCAGGSGTALTATRFGVPQLVLPQYFDQFDYARNLAAAGAGLALPDGDSQSDHDLLTGSLAALLDDSGFASAAAKLGDEIAEMPRPTEVVRALEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW85</accession>
    <name>A0A7W7WW85_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="31699" checksum="FA849244235413D1" modified="2021-06-02" version="1">MAAVDPARPWVAVRGDESTDGRWRAIGPSPPASAAKGRAQAVDRRMADGMSSEVGTEVAWPAGPDSGRGRGRGRGRRSTTGPDASGAAHRSRCRPLDGIPTVSAARVRVVAEAGRGVPVDSGIVPARRRSPTAAHTGMVGSCGGHGEPGDSAIVRPKGRLTNEIHPVRDGHGRLRSLVPTPAAISTTAPRSPPSWLNGVPTAGPAHAVADKASRPRHSAPTCATRGIPATIPEHGAGRPANGAAAEPSNTHRPSIASHCLQRSASKAGGRPPREPSVARRAIRPLRSRQVKVTRRVRRACPADLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW94</accession>
    <name>A0A7W7WW94_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10164" checksum="1E3AC4CFF98D3161" modified="2021-06-02" version="1">MAPGFGANTAAVKETAHELARIGVDVGDAVRGMGQPEVAEEVRESLRRFLERTSMASTRAGRQVVLAARRFRAVADELADLDASLAGDVPTENQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW96</accession>
    <name>A0A7W7WW96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046264">
        <property type="entry name" value="DUF6297"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19814">
        <property type="entry name" value="DUF6297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="441" mass="46660" checksum="06A5F7E004FBEBC9" modified="2021-06-02" version="1">MTTSAALSRRLRRSRRRDPWRFRLSRAVDRITYTAMFTGIALGAVAELLAFTPAPDTLWNPIAVLVGVLAATAQIGVLLAFGPVVARGAARFWVLSTPVDRRGLLVPRFLAVLAVSATVGTVVFALPFVLMRVSGPWSVAGALGGVVAASVTVIVQPHVSRAPRRVVNGVAVTAWMSILALLLVRPTMSGIGGVTVPLVPVALAAVVSTGVAVWTLGRLNRIALAAGTELASALAVSVTFLDSALFTSLMTSRRTRALGRVRSARLHGRRFAVLLRADCRRVLRLRHVPLVWLGLIPVPYAIGLGYDARTQAVLHLLCAFLAAGQLSGGLRAVCGSGALRRSIGGTDRVIRTAHLVVPTVGTLVWCAATTPALPWTGTAVLSAFGAVLAVYRIATKPPLDYSAPLFDFGGYGAVPLTFILRLARGPALLLVFAYAQILLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWB2</accession>
    <name>A0A7W7WWB2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23494" checksum="A8F323D520CB9A0C" modified="2021-06-02" version="1">MVREVGLRERKKRATRAALAESALRLCVENGFDAVTAERIAGAAGVSLRTFFNYFPSKEEAVVAAEVARAEAIVREFAGRPAHEPVLVALRNTLHRLLAGRLDRDDAARLRALRATPALLPYQTAAYAAKERQLAEAVARRVGADPDADLYPTLFAAAVMATLRVVVGRWLDSPTTPLSELVDALVHRLGSGFGDHVQASRTAAVPAQASQVTGSECTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH9</accession>
    <name>A0A7W7WWH9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III epsilon subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="16"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="199" mass="21765" checksum="957BB638700F795E" modified="2021-06-02" version="1">MNGPEEELPEVLRDRRLVVLDLEGDGGSPPGIVEIAVLPVDGPVAAKDVRSWLVNPGRPIGVHARRVHGITDVQVAGKPLWHGVGPEVLGWVRDRVVVAHNAPVDRKVLAAHLPAWRPTLVLDTLRLARRVWPDLSSHSLEALTAHAGIEPEGRAHRAGADVWSTWRVFLLLVQGLSWERVVELAAVPLPVEESEVGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL7</accession>
    <name>A0A7W7WWL7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030910865" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="22944" checksum="6A41EDBE6A4F36A4" modified="2021-06-02" version="1">MRTAIALAALTLVAGCGLGAPPGGGVADGRVPDGTPDAAAARTLLAGLVVAEPGTLKGYERDCDKGAACVFGRAWKDVDGDGCDQRSQVLARDLTDVKRKDGRCGVESGTLADPYTGETITSVSKIQIDHVVPLAEMWRSGAAAWPADRRVAAANDLRNLVAVQGKANQSKSDHTPDEWMPPNAAYACSYGRMYVGVKANYALTISAPERAALESALAKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM1</accession>
    <name>A0A7W7WWM1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheY-like chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="137" mass="15070" checksum="63CBECFB668AAF2E" modified="2021-06-02" version="1">MTDDTLVLVVEDNEVDREAVARALSRSHPELTLEFVPDGDAAVTRLHDPSRPRPGLLLLDLNMPGTDGHRVLSDLRADGAFDDTTIIVFTSSTTTEDIDRCYAAGADSYVYKPVNFALFRTVLQGAVDYWLENRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY6</accession>
    <name>A0A7W7WWY6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formate-dependent nitrite reductase membrane component NrfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="58" mass="6492" checksum="B7C8D91D291566AB" modified="2021-06-02" version="1">MDWRVPVVYAAGLVVALLLLGRRKKVRPVAVRVLLAVVWPAVALWWLVFTLSKPPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWY8</accession>
    <name>A0A7W7WWY8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025855">
        <property type="entry name" value="Replic_Relax"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13814">
        <property type="entry name" value="Replic_Relax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="39400" checksum="E539390830641AFB" modified="2021-06-02" version="1">MITNPTRQRALRGHKPTRPTPRVANTAEHQAVLAWRLTPRDKWIARMLWEHKVLTAHQITALAFPSFRSGRMRLRELYLWGVVDRFQPFVTLGTAPMHYVLAPAGAAVLAAEDGLDVKELGYRHDRVFGVAHSLRLAHTVGVNEWFTALVDRARNPHPGEQVELAAWWSETRCARHFGDLIKPDGYGRWRSGERQVEWFLEYDFGTEPLSKLAGKLAGYAALAQATGITTPLLVWLPTSRREAAARRLLAKAWRELDDRRSVPIATAAAELLNPEATHPSPADEVWLPLNAPAGASRRPLSGLPDAWPHVPPPVTPNEEAPAGADSPQPMSPPPSPMPPTSTSSRASRGAGRPGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX04</accession>
    <name>A0A7W7WX04_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Formate acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="5 7 8" id="KW-0556">Organic radical</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="10">
        <location>
            <begin position="1"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="7">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="748" mass="82890" checksum="F983744A08A62FFA" modified="2021-06-02" version="1">MTAVEERLDAWAGFRGSDWRHDIDVRGFIQANYTPYEGDAGFLAGPTERTATLWRNLSGLFAEERRRGILDVDVHTPSTITSHRPGHLDREHELIVGLQTDAPLKRAIMPNGGLRMVEAGLAAYGYEPDPTVREIFTKYRKTHNDGVFDAYTEQIKRARRAGVITGLPDSYGRGRIIGDYRRVALYGVDRLIDAKLAERAAIDDVPSTEEVIRDREELAEQIRALGELKEMAASYGDDISRPAATAREAVQWLYYAYLAAVKEQNGAAMSLGRTSTFLDVYLQRDLDAGLLTESRAQELVDDLVIKLRIVRFLRTPAYDELFSGDPTWVTESIGGIGEDGRPLVTRTGFRFLQTLYNLGPAPEPNLTVLWSPALPEGFKRFCARVSVDTSSIQYENDELIRPRFGDDTAIACCVSAMRIGRQMQFFGARVNLAKALLYAINGGRDELTGDQVAPHRPPIAGDYLDYDEVRAAFDRMLAWLARTYVDALNIIHYMHDKYAYERIEMALHDHPAQRLLGCGIAGLSVVADSLSAIKHAKVRVVRDDTGLAVDFVVEGDFPRYGNNDDRADALAVGLVEDFMALVRGYPTYRDAVHTQSVLTITSNVVYGRHTGNTPDGRRAGEPFAPGANPMNGRDRHGLVAAALSVAKLPYDQALDGISLTASITPDGLGRDTEERVTNLVGVLDGYTDAGGFHLNANVLDRDVLLDAMAHPDRYPQLTIRVSGYAVNFVRLTPEQQRDVVNRTFHGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX08</accession>
    <name>A0A7W7WX08_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="32"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22412" checksum="9AF2F229AF3195F9" modified="2021-06-02" version="1">MGWWSAFGRNRGRDGKKTGPPVHDDLVQRDFTAAAPNRVWPADITGHRTTAGKLYLRAVKDVHSNRIVGYSIDSRMKSRLAVTALANALARRGDVADCVVHTDRGSQFRSRKSVRALARHGLAGSMGRVGAAGDNAAMESFFALPRNNVLDRRTWSTREELRIAIVTWIERTYHRRRRQAALGRLAPVEHEAIMTTSASQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXG1</accession>
    <name>A0A7W7WXG1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030629872" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="20790" checksum="31FFAA6E1A7730EE" modified="2021-06-02" version="1">MRWWGVVVAVSGMLLAACAQAEPGVARPTGGVWSDVQGRWWGWASVPEARNPVADRTGEFCGEGQPDDVWFVAGTFGGAVERTCEVPAGRPLVGPVVNRIGTSGECALFMADAKGQVSLDGVPVVPHEVGAVKTVVRAGADNSWDLRAGESRVTACGLWLWVPPLSPGRHELRFEGSTGKFHVAAVYRLKVVGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXU8</accession>
    <name>A0A7W7WXU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose synthase/poly-beta-1,6-N-acetylglucosamine synthase-like glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="244" mass="27244" checksum="1F2CBDDD029C2C1E" modified="2021-06-02" version="1">MSGNVKVAGRAGLLGRWQHLEYTAGSGLDRQILDAFECLPTIPGAVGAFRRDALVEVGGIGTDTLAEDTDATIAITRAGWRVVYEPRARAWTEVPRDVRALYRQRCRWSYGTFQSMWKHRAALREPGRMGRFGLLYLFLFHLVLPLGPAMDVFVLYGAFVADAPMAIVVWLVFLAVRTVSAGYALRLDGESLHPLWTYPLRQVLYRRLTYLVVVESLVNAARGTPRGWSWARRQGVVGPVPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYC2</accession>
    <name>A0A7W7WYC2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="14469" checksum="734E3BB269954427" modified="2021-06-02" version="1">MAVRLGSVQVPAAAVVGFVAVVIALVVFLPGDDAAEGTTTTAATVVESASCGGADAYDKVRVEIGGQPRDVRFDGCGHSVGEVFDVTVPPGADGDVMVGRAMSGPVRSQGGGPLGILLTCLSAAAGGFYAHLLRTRPQATSAADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ71</accession>
    <name>A0A7W7WZ71_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1(Or 4)-monophosphatase</fullName>
            <ecNumber evidence="3">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="28683" checksum="89E89414CC18F142" modified="2021-06-02" version="1">MKRSYAQLTEIAQKAVRIGGDVMKHARPTTVTEKSDRDSYTDVDLRIEQEVREYLAEATPEIGFIGEEQGRGGQAAQSAYVWLLDPIDGTANFVHGIPLCATQIALVHEGKPLVAAMSFPYLEADYWASQGHGAFMNGKKLAVSDTARLDKAIIAIGDYATGPESGDKNKVRLELTRLLAEQAERVRMFGSAAHDFAWLAEGRIDAAIVLSNDLVDIFPGVLIAQEAGASLRDALGNDHTANSSSTVGACPGISEQLAELLRGLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZJ7</accession>
    <name>A0A7W7WZJ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YbbC (DUF1343 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030998212" evidence="1">
        <location>
            <begin position="28"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="44565" checksum="D56996A5AE12A89A" modified="2021-06-02" version="1">MIGRREVLFAAVTVPAAGLAPASTAGAEAAAVVATGRRVVTGADVLAADHWRGLEGRVAVLGNPTAVLRDGVHVVDSMVAAGVPPVVVLGPEHGFRGTAQAGGSEGDHADPRTGIKVRDVYRADAAKFAGVLREERVDVLVFDIADVGARFYTYIWTMLTAMTAAASVGARFVVLDRPNPLGGKAKGPQLLPGFASGVGVKPVVQQHGLTVGELAGLFAGEFLDTPLDLDVVEVRHWRRDDLDTGLAWVPPSPNMPTRDTALVYPGTCLFEGTSFTEGRGTTKPFETVGSPDVDWRWAEDLNGERLPGVRFRETYFAPAFGRYAGRTCGGVQLQVTNAREFDAVRTGVAMIVTAARRYPFAWREDNWVDLLFGSDRLRRMVDARAGIDDIVGSWRQELDEFDRTRKPYSRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXG6</accession>
    <name>A0A7W7SXG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="198" mass="21594" checksum="BB1295E5DE1D3764" modified="2021-06-02" version="1">MHPLAAAVRRLTLPVVRRFTAGRTVSDAVDAAETLVDQGFRVTLAGGGVDGESYLRLVEELAAGGLLEDTDLEPEVDADRVRALGARVVRRVPASDRLAVESDRVHLAERGPSHAAKLDYVRCVNALLAAPGEPVFSTGDRRLVEIIGERARWYDRPPGSFEYEVPLGARGRHALSALGHTVRVRVPFGPRWYAVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXI7</accession>
    <name>A0A7W7SXI7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ring-1,2-phenylacetyl-CoA epoxidase subunit PaaA</fullName>
            <ecNumber evidence="1">1.14.13.149</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.149" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097266">
        <property type="term" value="F:phenylacetyl-CoA 1,2-epoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011881">
        <property type="entry name" value="PaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007814">
        <property type="entry name" value="PaaA_PaaC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05138">
        <property type="entry name" value="PaaA_PaaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02156">
        <property type="entry name" value="PA_CoA_Oxy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="35134" checksum="8C3EF290B1026730" modified="2021-06-02" version="1">MDLEARFERTIASEQRVEPRDWMPEGYRKTLVRQIAQHAHSEIIGMQPEGNWITRAPSLRRKAILLAKVQDEAGHGLYLYAATETLGADRADLTEKLITGRQKYSSIFNYPTPSYADVGVIGWLVDGAAICNQVPLCRTSYGPYARAMIRICKEESFHQRQGYELLLTMMAGTDAQRAMVQESVDRFWWPALMMFGPPDAESTNSEQSLAWRIKRDTNDELRQKFVDMTVPQAEKLGVTLPDPELRWNAERGHHDFGQPDWDEFWQVVKGNGPAGAQRLAHRRKAHEDGEWVREAARVHSEKKRGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXY7</accession>
    <name>A0A7W7SXY7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CspA family cold shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4962696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="68" mass="7485" checksum="CFADF3F8626F9EDB" modified="2021-06-02" version="1">MAIGTVKWFNAEKGYGFIAQENGGPDVFVHYSEIDGAGYRSLEENQRVEFEIGQGTKGPQAQGVRVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXZ1</accession>
    <name>A0A7W7SXZ1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ORF">F4559_000350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4962991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="526" mass="54445" checksum="7446BA36A0E7ED61" modified="2021-06-02" version="1">MTTPAQRRPVRRALIGVSDKAGLLELAGGLHAAGVEIVSTGGTAKALAQAGIPVTPVESVTGFPEALDGRVKTLHPGVHAGLLADLRKPSHVEQLADLGIAPFDLLVVNLYPFARTVASGAGPDECVEQIDIGGPAMVRASAKNHASVAVVVDPSRYTWVLEQVTAGGFTLADRQALAVDAFRHTASYDVAVASWLGSVVAPDDDGSGFPGWVGATWDRGQVLRYGENPHQKAAIYRADGRSGLASATQLHGKEMSYNNYVDADAAWRAAWDHVDPCVAIIKHANPCGIAVSTLKGDAAIADAHRKAHACDPVSAFGGVIAVNREVTVELAEQVAEIFTEVVVAPSYADGAVDVLARKKNVRLLVAEPPVRGGTELRPVSGGLLVQTVDTIEAPGDDPAAWTLACGEALDEAGLADLAFVWRAVRAVKSNAILLASDGATVGAGMGQVNRVDAARLAVARAGDRARGSVAASDAFFPFPDGLEVLVQAGVRAIVQPGGSVRDAEVLAAAEATGATVYLTGTRHFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY67</accession>
    <name>A0A7W7SY67_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase (TIGR01509 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="28835" checksum="F54059FE231EFBF2" modified="2021-06-02" version="1">MTPKVLLLDLDGVLRRFGSDDAIEDAHGLPRGRLAEVAFGLAGPALVGADTDAAWRALVRGRLVADGLSADVARSAVAAWSRVGELVPEAIALVRRVRCRVAVLTNATDRLPVDLARLGLDREVDAVVSSAVIGAVKPAPEAYLRALDLLGVEAADVVFCDDKAENAAGARAVGIDGVHTPDYPALEAAVADRGLLGPLLLVLHDRDEAVAAARELADGGWAPALVHKDLLAGEDDVEDADWVVELATGPDGRSAHRHRDLLETVADRVDGFVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYC7</accession>
    <name>A0A7W7SYC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein YdbS with pleckstrin-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14015" checksum="351470D85BC535BE" modified="2021-06-02" version="1">MSESKQVPVAVRVAGVFTAVEGLLGLGFAVALVVRAFAVDEPGKVLGEAAYFVVLCAGVLACGIGLVLGRRWARSPAIVVQLLLLGVAWYMYGPSARQLWGALLALYVVLVIGSLFTNPVRRWALGVDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYC8</accession>
    <name>A0A7W7SYC8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031098520" evidence="1">
        <location>
            <begin position="33"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="24831" checksum="1CF927E1CF424DD5" modified="2021-06-02" version="1">MRFTRTVQAVVGTTAAFLSAIALTTIAPSASAAEGGVTPYIIGGGTASNAPWAARLFANGQQTCTATIIAPTWILTAQHCVAGGGTMTFRVGSLDQQSGGTMATAKRVIQHPSVDLALAELTTSVQATYAPLGTTASTRNGQTVQIYGWGATSRCGSEINCQSRYLKVADTRVTNTNGRDYRGGVAITVTRGNGIAAGGDSGGPMFASGVQVGVASTSDRQSTSNYTSVGTYRSWIKQYAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYH7</accession>
    <name>A0A7W7SYH7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21459" checksum="08885EC2E4CB1936" modified="2021-06-02" version="1">MRIDAVRNRAKLVAVADICFARHGVTVSTDLIAKEAGVGIGTVFRHFPTKDDLLAEVNAARLRRLAEQAGTFSTERSPGEAFFAFVRAVAGQDDFKNTTVEALIAAGVDLADAEEEIAGQLRTNLTRLLDDAQHVDAVRDDLGFAELRALLVGIGNALGHAGPDAHERVLSVFLDGMRPQRQSGRNGIRDDDPSSLTPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYN8</accession>
    <name>A0A7W7SYN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_000673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022446">
        <property type="entry name" value="CHP03704_MeTrfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03704">
        <property type="entry name" value="PrmC_rel_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="5">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="27768" checksum="61777A99422C8039" modified="2021-06-02" version="1">MTDEDPIVAALRAAGCVFAEDEARLLREAASGDELTTLVRRRVDGQPLEHVLGWAGFRGLRVAVDPGVFVPRHRTGLLVDQAIPLLSPGDVVLDLCCGTGALGAAVAAKIPVELHAADIDPASVACARRNVPRVYEGDLFEPVPTALRGRIAVILANVPYVPTEEIALMPPEAREYEVRVALDGGDDGLTVLRRVAAEAPGWLAPGGHVLSETSGRQAPVALAVFRSHLSDARIVEDDDSIVVIGTKQGRPGPKSGAAPGVKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP2</accession>
    <name>A0A7W7SYP2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031364411" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10176" checksum="9A4D55E095E011F1" modified="2021-06-02" version="1">MATKVLVTLPMRKCPSTRAAPAACVEVVVPSSTRIRADEAWRSTIQESGCPAGTATRDATSAKVLIITGSTPGTSAGTDHEDDHPVRWGKPHPRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYQ5</accession>
    <name>A0A7W7SYQ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="143" mass="15138" checksum="7B0785C98C396923" modified="2021-06-02" version="1">MSFTARWSIRDVDGGPDKGAIRTVTTDAEVDDLVGLLSDDVAETARIHHADRPLVPAPFTGKPGADHVLTAAVHAGYGYLGYLDPDHDFGHPVGDPASPVYHSDSEEFDAGSGIPVETLTSALKEFLATAQRPTCVDWTPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYY4</accession>
    <name>A0A7W7SYY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="343" mass="36075" checksum="3F1F3C734EC63A8E" modified="2021-06-02" version="1">MSDAVRTLLLNAVRRDDLPAVRGLLRGGVDLNARGSDGLTALMVAAGKGNAELVGVLLDAGADVHTADSVAGGTALHKAVQGGDLDTVKLLVAAGAFVDAVAVSTGHTPLLDAFWYKRPDLVGYLLDRNAGLNLGTHYGFSMRDHFEYALNVNTLGREKLLAAEALLRRRIAADERAVADQRLMAATIEGDLIAVQVLLADGAEVDARYPVLNGFNDLHTPLLVASRDGHAEIVRALIAAGADVNATEPTFGAVPLHKAVYNGHADITAILVRTPGVDIDFQGATNGYTPLHDALWHGFEDCARILVDAGARLDLVGHDGLTAAELAADVFGRDHALTRELAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ6</accession>
    <name>A0A7W7SYZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17442" checksum="1395431BD5FA1120" modified="2021-06-02" version="1">MADRHIIDVHLLLIRDNHILLTRRRDTDPRFDGRWHLPSGKLDAGESVLYAACREAHEEVGVHIDPAHLRLVHTLHVNGSGLEPRLGLFFEALRWTGEPTNREPDKCSAVDWFPLDALPDDLIDYPAAGIDAYRTGIAFSAHGWPATRADQQTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ48</accession>
    <name>A0A7W7SZ48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA/ethylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="3">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15409" checksum="59A47683FF59B332" modified="2021-06-02" version="1">MRAELGGYVTAIDHVGIAVPDLDAAIAFHREHFGLEVAHEEVNEEQGVREAMLRAPGDPSGAAVQLLAPLTPESTIAKFLDRSGPGLQQLAYQVSDVDAATAALRAKGLRVLYPEARRGTAGSRVNFVHPKDAGGVLVELVEPGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ96</accession>
    <name>A0A7W7SZ96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="428" mass="45357" checksum="2CA88725881C5128" modified="2021-06-02" version="1">MEAKGFRGARYIAVVLLVISVAALVLFGAVQAKPVQAVALGLIIALGSTITGALLGFVFGIPRRVQGESGTTGYAVNTNFEQISDWLTKIIIGLGLVELGSIVGHFGRLSTTLGAALGPGTATTVAAGATIVFFVPLGFLVGYLLTRTFLTDAFRSFDDLPANAVTDAVDRVGTLAQRRYRSIHADYENQSHLPADNRNRETVERAAEATSPVSDVVTLCGEIENLLAELLAPYPSQDLASDELVDLLAARGVVDAELADALKGLFEFARKVALGRPLAPVDAVAVRNQGTAVLAEVGRLRRIAGVAFEKHVVDTLLDAAGGRGWRVVTDALVSEVPRVHVDALVVNGAGSVMVEARSLRDPVAVADLQGWLDHVPEQPLVLVVPGDQRQRARVEGLGRRGDVRVVMWDLEPGALVPLVEELLGRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZB2</accession>
    <name>A0A7W7SZB2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase / fumarate reductase iron-sulfur subunit</fullName>
            <ecNumber evidence="8">1.3.5.1</ecNumber>
            <ecNumber evidence="8">1.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_001057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="8"/>
    <dbReference type="EC" id="1.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4963698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26727" checksum="F32B4591921302C5" modified="2021-06-02" version="1">MNLTMRIWRQNGATGRLVTYDVPDLSPDMSFLEALDVLNERLVLAGEEPVAFDHDCREGICGMCGLMIDGVAHGPERATTACQLHLRHFSDGDTVTVEPWRATPFPVIRDLVVDRSAFDRIVEAGGYVSVSTGSAPDAHALPVPKPDADAAFEAAACIGCGACVAACPNGSAMLFTAAKVTHLGLLPQGRPERGTRASDMLAAHDDLGFGGCTNTGECTAVCPKGIPLSTITRFNADVLRAARSFSQGDKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC0</accession>
    <name>A0A7W7SZC0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030819699" evidence="1">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="23373" checksum="CE103484E596665A" modified="2021-06-02" version="1">MPIVTRPPLAALFVACVAVAVTAAGMAYAFSLRPPATSTTQVTTTTPKDDLRCGKAPCTPLTSREVGTDTVELLAGGDVGRIRISGPAGRDIFESISAQQGAKLSTDSLQCVVGEVALCLVRGTAPGAVVGEVLLRRAGAWTRAEVPYLASGDYLGLHDVNGDGVADVVAVQSACGQAPCPRRFTQVFSVVGESDLGCSAVVDQPQDLPGWPTVTPDPASLRSECAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZD2</accession>
    <name>A0A7W7SZD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="22451" checksum="EBED05563D073819" modified="2021-06-02" version="1">MRFDTTRPAAASPQHYHATPPERPLPEYAELTDDEFTALYRDTLGQGEAPAEYFAAELLRRFPGLQFAHRQYKDSFRRDMDETTATEKAAGTWNVMKVVPVEPSEQTQRLAEAFAALVRATAYDDDTSLRARPTITLDEILERAQIKRDTWHGYISRGQVGGRIGHDWHTGEPVWDRDVVEYWMRRRRTPARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZH3</accession>
    <name>A0A7W7SZH3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19318" checksum="0A347DEE4518786A" modified="2021-06-02" version="1">MTAPDETRCMPGSTVPELRDRIAQLTAGADPTPYDPGVWPTPAQYVHRWNLMTGPERLAEADRTISLLKELGPPNWLDIRGRVVDPESAPLGTTLLFPEQQDEHHWPEIAIRWSPPGASDEPYPWLIVGSEGPQKLSHDVVVGCTVLTGRLTTLCQAVEAETQARASRHGDRGTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZK6</accession>
    <name>A0A7W7SZK6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9722" checksum="DEAF6A1A19C57F5A" modified="2021-06-02" version="1">MAAAVVSLVLAVAALVVVQRNWLTLADTERILGDNARTLASVTGDRETWMASAVRHYARARAFERRAWPFRPKRRGVRESDPSTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZR3</accession>
    <name>A0A7W7SZR3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="126" mass="13815" checksum="C088AF34A3A6C81D" modified="2021-06-02" version="1">MTAAITPTDSNLVAHARRELQRLGEDPDTIDGIVAVVQAFADCGHSGGSAPHAIAYLERLLRFEPLSPITDDPDEWIDRSEMSGMPCWQNLRHSRAMSHDGGKTYWLVEDNVPVDGVTPTYVSEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZY9</accession>
    <name>A0A7W7SZY9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-coenzyme A thioesterase PaaI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027961">
        <property type="entry name" value="DUF4442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14539">
        <property type="entry name" value="DUF4442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="17959" checksum="9832D4FF2CD97846" modified="2021-06-02" version="1">MKASTLRRGMNLWPPFLFSGIRVVEISDDYRYARVRMRLRPWNRNFVGTHFGGSLFAMTDPFWMLLVLHNLGRDYVVWDRAGEIEFLRPGRGTVAAEFRLTDEHVDEIRARTGDGDKALLWFPVDVVTPDGQVVARVRKQVYARRKNRDHVPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A8</accession>
    <name>A0A7W7T0A8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="25687" checksum="65866288B275793F" modified="2021-06-02" version="1">MTGVGTNRHLDLLVVINEIARADQVPVRVRHVCLACKVRLNAAGVAVYLVGSAQPLEVAGATGEEMAELQATVGEGPMSEASRQNHPVFVSDLADGWSASRWPAFAAAAAAAGVAAVFVIPLTLGAIALGALEICRDVAGPLSQDELADALLFADTATTLLLGGPATPATPDGADLWGTEPERRWGVVHQATGMVSVQLDTDLGEAFLRLRAHAFLTGNRLSEAAADVVARRLRFTPDTNHEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0I3</accession>
    <name>A0A7W7T0I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036170">
        <property type="entry name" value="Prob_YezG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160424">
        <property type="entry name" value="SSF160424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="273" mass="30934" checksum="00ED6F18FA62D65F" modified="2021-06-02" version="1">MSRPDAPPNEQDQEQLVRRLGRAMLPALPPDWRRVRAEYRAAGRHIEVDLAFAGPDGQWRPIRPPMDVVRLFGELRVVMHTPDRGTWLSAVYEIEAPSAFAVDFNAEDEPRWRNAPPVIGFQDELRTFPRADDRIPDWLRERLGLPPLRAVELRMANVYDGRDGEGRPVVNRTVLDPEVLEPLLVYLESAPVVVVADEAPGVDEFVPDERDVPPTFQTDGTWVWAGAVPHYLRKYGLPPDPELVGHVVALGFDLSDVDERTLRHAAEWVRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0I9</accession>
    <name>A0A7W7T0I9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="19510" checksum="76DE582B5EEB4DA6" modified="2021-06-02" version="1">MADDLRPDIQAAKDRMRTRMGAGREIKRLVEYPREGERVELMAAGTYGPGQGLVVLSDRRLLFLKDGIGRQASEDFPLEKISSIQWSAGLTPGSLTVFASGNKAEIKNMNKKDGRQIADTVRDRLSSSPMPVTQPNPASAEPDVFERLREPGELRDAGIVTTDEFEAKKRELLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K8</accession>
    <name>A0A7W7T0K8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntP family gluconate:H+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="463" mass="47389" checksum="E74E13E777C778CE" modified="2021-06-02" version="1">MIDWLQHSTGGLLTLSGVGIAVLLVLIIRLRVEPFIALLVVGLLVALAAGLPVEALVGSAQKASDSLVEKGFGGILGHVAVIVGLGTLLGSILEASGGAQVLTRTLLRAFGERRAPLAMGLAGLVFGVPVFFDIGIFVLAPLVYVAAKRGGRSIVLYALPLLAGLSVMHAFMPPHPGPVAAAGLLHVGLGWIIVMALAVAIPSWFVGGVLFSAWIGKRVVVPVPEEMLAAAEKARGDRDEPPLSLVLGIIAVPLVLILSGTFGSVLLAKGSTPLGVFAFLGTPAVALTISVLLAFWLLGFRRGMDRAQVAELSAASLRPVAMILLVVGAGGFFGAVLAATGVGKALAGSLADLGLPVIALSYVISCGLRIAQGSATVAIVTTTGIVAPVVADLDYSQPRLALVVMAIAAGSIIASHVNDGGFWIVSRYFGLSVKETLRTWTVLETILSVVGFVVTALLSLVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M1</accession>
    <name>A0A7W7T0M1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014995">
        <property type="entry name" value="DUF1844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08899">
        <property type="entry name" value="DUF1844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="113" mass="12070" checksum="41EDC38434B9F6D0" modified="2021-06-02" version="1">MTDQPQHPVRELSDVPSVEVISKAAVMLLSAAAERLGLADEDPDTSPHRDLDEARRLITALAGLITASVEYLGPHAGPLREGLQSVQRAFRETSAVPDEPGQGPGEKFTGPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0W8</accession>
    <name>A0A7W7T0W8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase-like predicted oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="278" mass="30458" checksum="74AE28C854BB582C" modified="2021-06-02" version="1">MSETYALGGDLTVGRLGYGAMRITGPGIWGYPDDPENAIAVLRRAVELGVTFIDTADSYGPHVSEDLIRRALHPYADDLVIATKAGLVRPSRTDWVPLGRPEYLRHALEQSLVRLGVERIDLFQLHRIDPSVPLADQIGELKKFVDEGKVRHVGLSEVDVDELAAAREITEIASVQNLYNLADRKHEKVLDYTIEHEIAFIPWYPVATGDLARPGGVLDQASRDHGATPAQLALAWLLRRAPNILPIPGTSSLAHLAENVAAAKIELTDEEFAQLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y2</accession>
    <name>A0A7W7T0Y2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Siderophore synthetase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IucA/IucC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="FhuF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="PTHR34384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IucA_IucC" evidence="2">
        <location>
            <begin position="131"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="FhuF" evidence="3">
        <location>
            <begin position="395"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="581" mass="63970" checksum="248682D9BAEB6D15" modified="2021-06-02" version="1">MTDLWHECSAALLAKAIGELCFEGLLTPGPGYALRFPDAVYTFTAERTAFGGWVVDPASVHRTATGVLGDDVVQPCADVQRFLADALVALDVDPATTAGFLAEVTATLAADVALAATARPSAELASMGRAELDGHLTGHPWLIANKGRIGFGAEDVARYAPESRTPLRLPWLAVHRGLAEFRGTSELSEEAVLRHELDPMTVERFTEVVQELGVDPRAYVWLPVHPWQLDHVVRTLWAPELATGRIVELGEGPDWYLPTQAIRTMSNVDDPGRFQVKLPLRVLNTSVYRGIPPHCTAAAPVVTQWLRGLWDADKLIGEWGTALLGEVASVTVRHPVLSRAGAVPYQWLETLGCIWREPVVERAGERSWSLAAVLHVDRDGRPLVRSFVGSADPEVWFSTLLRVLLRPLLHLLYTYGITVNPHGENVVVITDGQGMPVRVALLDLVDDVNLSVDRVPERGPEPDAHDHVLPRKPWRVLRQYIVDALLIGVFRPLARLLDVPGERFWGLVRGEVDAYRTRFPSLGARMDAGSLTEAEFLRFPLNSYRLTLGYRDLAARPPVPTTGTVPNPLHHVTAVPPHDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y4</accession>
    <name>A0A7W7T0Y4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LSDAT_prok domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041482">
        <property type="entry name" value="LSDAT_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18171">
        <property type="entry name" value="LSDAT_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="LSDAT_prok" evidence="3">
        <location>
            <begin position="165"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="521" mass="52946" checksum="79B38F8AD684D458" modified="2021-06-02" version="1">MPTPGPRVRRLTHPDAEVRARALGLPRNRPALVVLGVHATVPAPGPPAAGSPGLSPGSPAAGPADPSSGPAGPPGDPSARLARGSDGPTGSPGRTSARVGEGDDPSARAGSADDRPGGDTSAGSGGGPSAPGGGARGGSGEPSFWSAPLTDSLSAGSGRAAAHAATGLDRDTAASTLTVLRAVLGYAGTAGVVVVTAGADTGITHLLGLAADAVATLPRLVGVAPSGRVAEEGEPSAGEVRLEPHHDAVVLVPGSRWGEELPALPRVVDAVVRSRRTATALLIGGDAATREALADHLGRDRPVVVLAGTGGLADDLAHGRVDDDLMVLARAGQVSVIHVDEGPDRVVAALSRVFADEPHVPAPVPAVWPRLRFHPPQRRPIVDPGFLLDYPLLADAVHEADRIVAPVLHECEVEAARERERVKLRTVLALGAGFATTTFGAVQVWLADTAWPGVVLAASGAVAAILVVLIRDGEDPVHRTRADRLRTLYFDHLATPPPAAEDRENRLRVLTASVAATATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y7</accession>
    <name>A0A7W7T0Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25835" checksum="709D0E5C00F92251" modified="2021-06-02" version="1">MTDVPANGHALLDFNAPLSDARSYDLISGLRALAGKDVVDYGCGWAELLLRIAAHEPGVRAVGVDDDEYAIGRGRAAVAERGLTNVTLHQADATTWPGRADVAISIGASHAWGGTQATLTALRERVTPGGLLLLGDGFWEHPPTPAATAVFAQDEFADLAGLVDLALAGGYRLLGLTTATLDEWDAFESRWCASREHWLLDHPDHPEHAAVQAIVDDHRDGWLKGYRTHLGFAYLTLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T191</accession>
    <name>A0A7W7T191_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17320" checksum="EDECAFEAB03E1678" modified="2021-06-02" version="1">MGGFDRPVDVGAVRGLVRDWFAALDRHDDADVLLALLAPIGLVLHLPGATVRDREGLRAWHADRVSTYFDETHRAHDVRVRVVSPRHAEVLVRVDWRASVWVPPAAGSTRVGGESTQRWSVVPWHDGKPRLRTCVLGGPTPVPGSVAPRAARPTGLGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T198</accession>
    <name>A0A7W7T198_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar/nucleoside kinase (Ribokinase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="38"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="36611" checksum="0118B2B7267B34BB" modified="2021-06-02" version="1">MTPEFDVLLSGTVFLDIIFTGLPRPPAPGTEVWAEGLGSCPGGIANLAVASSRLNLRTGLAAAFGEDVYGDFCWEVLSEQEGVDLSYCRRFYGWHSPVTVSMAMDRDRSMVTHGHRAPVGADEMLAPPPRTRAAFVHLQPEEERWVCAARERGALLFADVGWDRTGVWAPELVRRLDGYHAFLPNHVEAMRYTRCDTAEAAARALADHVPVAVVTRGSAGAVAVDAGTGEVVDVPGLDVAALDPTGAGDVFGAAFVLGTLSGWPLGDRVRFANLCAALSVQHFGGSLSAPGWGDIATWWRTVSRRPNPEVLEYGFLEDLLPHHAAGEVRRASATIKLSTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A1</accession>
    <name>A0A7W7T1A1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="549" mass="58208" checksum="F0EE6E0A47175E5F" modified="2021-06-02" version="1">MSEREHTGRILDGRFELLGRLGSGGMGTVWRALDLGLHREVAIKEVRPADADQIESNPAMAAQLRERVLRESRALARLQHPNVVSIYQIIESPDSPYPWIVMELVRGTSLDARLREGVLTPAEAARLGRDVLAALRSAHSAGVMHRDVKPGNVLLRTDGSAVLTDFGIAALHGSTQLTATGDVIGSPEYIAPERLRGDETQTASDLWSLAMLLYVAVEGIHPMRRATTMATLAAVMTEPVPPPRRAGALAPALNAALRADPAGRPTGDVLDQMFAAAERDQAPPLGPPTPAGFPFPGPPSGPQQPQYAQWPSGPTSRPSIHPPSYPTPVPQTPKRRTGSVVFSLIGVIAVVAATLLVIKLVEGKGTDNGANPSTGSTAAPQNGGRTDVALPTGPKTTAATPAKDDLLTPAGARKVVEALSKVMGGTKVTDLTLWSERASAVAPTAAVENGYDNFAYSNGKATRQGPKGVDADEVTLDLNDVNWDALPALFDQANKELNVPNPTMRYVIIDTGLIDKIATVRVYLANEYGGGYLRANLKGEVEKVYPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1I0</accession>
    <name>A0A7W7T1I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15749" checksum="05E19DD6B2DB5FC8" modified="2021-06-02" version="1">MAQGLKVYYDAGHADDPVVVTTPQQVRELLATVRDKHPAGNAVLLTIVHAEDPWSSELNAGLDGDVGVLHYSGEDHPDGAYSHSRMPSNSEPVIYYYVTADTEFPPDSEVTAADVEDAVVAYLATNQRPETVPWQTGHRPPQGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1N5</accession>
    <name>A0A7W7T1N5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18527" checksum="13A62AD343048757" modified="2021-06-02" version="1">MPVEHTLRKAAEEVDRGDLASVLRARQRLVGLVTTYPDRLDLRARLAGVYRLLGDPVQAGRWSYLGEDRYDAEVAAFERAYRTPKARLAALNWATGANGIPSETARVRLAALQSEVSAQLRREIAVADDRDSSWTVNVLVLLGLVLALLCFVVGAVTLVLWAYHWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R6</accession>
    <name>A0A7W7T1R6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferric iron reductase protein FhuF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024726">
        <property type="entry name" value="FhuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11575">
        <property type="entry name" value="FhuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FhuF_C" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24240" checksum="9D38579FC21F5118" modified="2021-06-02" version="1">MSDFLQVLSTLRQVRVLGGHFALDVGRPDDEWSSGADILSGDALPVTLDKIFARYRTDERRVAGSLFLIGFAARVLSPVVAAHAVKGAVPDIRPENLWWHYGPQGLRVRLYEPVEAEHDIADSLAPVVEAVHRETRVARGLLWGNVGSTIAGALRMLARNGTAPVDRCHRLGERLLEKSPLSGTGEFTPLPDDLAFRRRSCCLYYRLEGGGTCGDCPIEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S1</accession>
    <name>A0A7W7T1S1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="207"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="462" mass="48958" checksum="5CB4C45D69D57280" modified="2021-06-02" version="1">MSDVIASEQLDLAKVVHDLVPALQEDLKTLVAIPSINAPGHEGDLENARTKIIEFFQGAGIHTQAITVSHGGKTTTPLVYARHDGPVGARTVLLYAHYDVQPADDNEWKITAPFQPKQIGEPPNTRLYGRGTADDKSGVCMHLGVVRALAGKIPVNLKIVIEGEEEIGRGVLEDYILHNDDERFHADLIVVADTGNVRLGVPTITTSLRGLAGATVSVDTLRQPVHSGMYGGPAPDAFMALTRILATLHDDNGDVAVKGLVQDSLGWPAVDESQFRRDAGLLDGVPLIGTRSIAERLYGKPSINVVGLDGPPSYAQATNVLVAHAKAKISMRIAPHQDPAKAVELLTAHIKAHAPWGVAVTVDPIDPGYGFAANTGGPYFVAAEQALKATYSTDSVVHGGQGGSIPLVHAFAHANPEADIVLWGCEEPLCSIHGPDESVAYRELEAMTTAEAVLLSRVGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T5</accession>
    <name>A0A7W7T1T5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16126" checksum="0790E5E2DCDE64F6" modified="2021-06-02" version="1">MAGGILDPDGARDRLEAWKGRIDKLAADTQAMSERFQNVRVTVNDQNGLAQVTVDSTGAMVDLRLTDRIHRVPPDEVARAILTTLGQARGELADRSREIITDTVGDSPAARAIAERVGNRLRGNESARVVSQDEDDGNDSRTYLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1X3</accession>
    <name>A0A7W7T1X3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease UvrABC ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">F4559_001901</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="479"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="513"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4964542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="785" mass="83871" checksum="46A8AA60FD198F65" modified="2021-06-02" version="1">MTHAADSHDLIRVHGARVNNLKDVSVELPKRRLTVFTGVSGSGKSSLVFDTIAAESQRMINETYSAFLQGFMPTLARPEVDVLDGLTTAIIVDQQRIGSDPRSTVGTATDANAMLRILFSRLGKPHIGSPQAFSFNVASISGAGAVTIEKAGQKVKERRSFSITGGMCAHCEGRGTVNDIDLTQLYDDTKSIAEGAFTIPGWKSDSFWTVKVYAESGLLDPDKPIRKFTKKEMHDFLYGEPTKVKVEGVNLTYEGLIPKIQKSFLSKDKESLQPHIRAFVERAVTFTVCPECEGTRLSALARSSKIKKISIADACAMQISDLADWVRGLKEPSVAPLLTTLGRTLDSFVEIGLGYLSLDRATGTLSGGEAQRTKMIRHLGSSLTDVTYVFDEPTIGMHPHDIQRMNKLLCRLRDKGNTVLVVEHKPEAIVIADHVVDLGPRAGSEGGQVVFEGTVDGLRKSGTLTGRHLDDRAAVKSSVRSPSGHLEVRGADTHNLRNVDVDIPLGVLCVVTGVAGSGKSSLVHGSVAKRDDVVVVDQTPIKGSRRSNPATYTGLLEPIRKAFAKVNGVKPALFSANSEGACPNCNGAGVIYTDLGIVAGTSAPCDVCEGRRFDASVLDYHLGGKDISEVLAMSVTEAEEFFGAGEGRIPAAHAILRRLVDVGLGYLGIGQPLTTLSGGERQRLKLATHMGDKGGTYVLDEPTTGLHLADVDQLLGLLDRLVDAGKSVIVVEHHQAVMAHADWIVDLGPGAGHEGGRVVFEGTPAELVKSRATVTGEHLASYVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T205</accession>
    <name>A0A7W7T205_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkylation response protein AidB-like acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="158"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="282"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="572" mass="61740" checksum="79FD1159489A0EEA" modified="2021-06-02" version="1">MTSSVSSPRTSTRSVLDDLYAGRVRWDLLSPFPEQDPDDRAIGDQAVAAITELLVDRVDPTVLDDTARLPDGLTDALQDGGFYRLLLDPSLGGLALSPLNALRVVSTAASWSPAVAWSLAIANGFGSGSYLPIVPAGPLRELIVDKVRAGIVSGSADTEVNGAANHRRHTTATPVEGGAAYLINGEKIFTGNGPLAELLDVSAVVTTDGVEQIRLFFVDTSTPGFSVVGTNEFLGLRGAPIGVLRFDNVRVPAENLLPASTDEWRYAPEIARLATLARTLIIASPSLAIAKLCLEWSREFVNRRVMDDKPLASYEEIQRTVARTAADVFTIEAVIEWGLLARDRVDTGADLTSAKNLTSVTCWHVIDRTMALLGGEGFETARSKARRGTTALPVERFLRDARGLRIAGGVDFLLDFWSAEGGLSAFYAEEGPIASAERVDDASLPPRCREHLTFLHAEAARFGDLCRRLTSTYTQEDLLAREHTVVLVGGIGNELLRIAIVLARAASRRDAFDLADIACTDARLRLNALWDQVESSDEPPYARVSDAWLSGTGYGFLVTDVITALPPVEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2I4</accession>
    <name>A0A7W7T2I4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase (APT) family kinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="27052" checksum="BCEAD9DAC2998E8F" modified="2021-06-02" version="1">MDVRAVLAANLPDLAVTSVVPLGEGLDNVAFEVDGSLVVRFRKDGDVAAEAAVLRAVAAVSPVAVPVPVFASGDRMAYRKLPGVPPAEVDVPPPGVLDTLIGFLRVIQALEVDVPVDVDDPAELLAEAAGRLGYVPAAYRADVTAFLAAPPPGRDHPVAFSHNDIGHEHVLVADGAVSGVIDWTDAAVVDPAYDHGLLFRDLGPAALAATPADLRERAVFHARCALLEDLAYGTEHGIDLYVRKSLASLRWVFSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U0</accession>
    <name>A0A7W7T2U0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031506596" evidence="1">
        <location>
            <begin position="33"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="12271" checksum="A8C886AE84A06927" modified="2021-06-02" version="1">MRGKIRRRKSGGVAAVIAALVLLLMAVGTAAAAPLSGGVDGVSRYSTGVVPSVVGWDVAPARGRPSRGFRGVDHRGLRGLRAALRAGAEPGRRGFGAAGFAGHLEDQPAAGARAALPVIRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E8</accession>
    <name>A0A7W7T3E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="8759" checksum="FE8CA185BE1047E9" modified="2021-06-02" version="1">MRAAPVTRRLCLATGFPVAEHDLPGALGEVRDEAARQVEEVGPAVSGTASNRRTGILRNLPAGRGTQRDITAAPLPDGCRTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G3</accession>
    <name>A0A7W7T3G3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NUDIX family NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16568" checksum="CCB57860DDA5F90C" modified="2021-06-02" version="1">MSAKHSAGIVLHRLHDGRREVLLGHMGGPFWARKDAGAWSIPKGETEGDEDPEVTARREFVEELGLPVPEGDLVPLGQVRQSGGKVVTAFALEGDLDPEDVVPGTFSLEWPPRSGTVREFPEVDRVAWFDLAEARVRLVKGQVPLLDLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W6</accession>
    <name>A0A7W7T3W6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="32390" checksum="8D67C690E338FEAC" modified="2021-06-02" version="1">MIDFEALRADGSWRLTWVDGRLDEAVFRAVPETADGRRALVEALGADASDPERWEAALVEALLVDPVSVGLRRLELHLTDFHHSARRAASAVATYRREQLSELYFGHDFEFLYENAQTSTGGWIDPEKHLADGFVGEAGAGFWAALPALRELTVEGAALFDDIDGAVLGNLTDLRLRGAVLAGGEVLPGRAPSVVTLVLDLESDVHGVACPVELLDELDPARFPGLRHLDLGRVEFDAGDVEILAALAGSAIVPRLESLTIRQLVVADHDVEAVGRSVDAFAHLRLSAAGAGAVEPDGVLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K3</accession>
    <name>A0A7W7T4K3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="16225" checksum="F9E4FEAEEADC4B9B" modified="2021-06-02" version="1">MDTLAVAGRFDLTDAQWAALEPLLPVPSRSGRPSLWSRRRLIEGIRWRVRTGAPWRDVPAAYGSWAATYALFRRRQRAGVWQRVLTALQALADEGGRITWDVGVDSTIARAHQHAAGARKRGICRPSRRAGSSPSPTTTRWAARAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M3</accession>
    <name>A0A7W7T4M3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031398552" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10668" checksum="7872B4A6EA3BE6B5" modified="2021-06-02" version="1">MTVLAAVATTVVAMTGTASAHTTTIYHGSDWASNDHSHLNVHDIECDNHGVWAEAYDNIGFFTVYDNTGCGGTGVHGDGVNIYLYRLCETGEGCTAWRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4N2</accession>
    <name>A0A7W7T4N2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="313" mass="33991" checksum="8F236D4CF0796C41" modified="2021-06-02" version="1">MPQHHTAAVNGIDVHYVEEGEGPLVLLLHGFPESWYSWRHQFGPLAAAGYRVVAPDQRGYGGTDRPAAVDAYTMPHLVGDVVGLIGALGERQAVVVGHDWGAPVAWHTALFRPDLVRGVVGLSVAPSHHMPVPPLSLMRQRFGDDFYQLYFQEPGVADAELAADPRATFRKVLVGGSATGTLTGRTAGTGFIGDLPEPATLPSWFTEADVEEYATQYGAAGFTGGLNWYRNIDRNWELTAPWRTARITPPAALIAGDHDLVRTFYPPGFLDQLAAIVPDLRAVVDVPDCGHWTQQEQPERVNAALLEFLAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P2</accession>
    <name>A0A7W7T4P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13586">
        <property type="entry name" value="DDE_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="132" mass="14815" checksum="F5D5D5DCE1ECFE01" modified="2021-06-02" version="1">MLTAGQRGDSPQFIPVLRGIRVPRPAGGRARTRPDRVLADKAYSSRANRAHLRRRGIRAIIPSKADQDANRKAKGSKGGRPPAFDPETYKQRHAVECGIDRLKRHRAVATRYDKLAVRYEATVHIAAINEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E9</accession>
    <name>A0A7W7T5E9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside 6'-N-acetyltransferase I</fullName>
            <ecNumber evidence="2">2.3.1.82</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.82" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047663">
        <property type="term" value="F:aminoglycoside 6'-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16116" checksum="20607A5F7AFDBB5A" modified="2021-06-02" version="1">MTIAPVVLGGAGPADLAAVLPLAVAFYAEHGFGTGEHALRDNLTVLLESPAARVAVVRSDTRPLGFAVTTTGFGLENGLIAELEDLYVLPSARRRGLGGRLVADSAAWARERGCRSLELVVAPNGRDIGPLVDYYLAHGFRDEGRRLISRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M5</accession>
    <name>A0A7W7T5M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Drug/metabolite transporter (DMT)-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="151"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
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    <name>A0A7W7T5X6_9PSEU</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
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            <taxon>Actinobacteria</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        </location>
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            <end position="121"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="25387" checksum="D268805A3B344E43" modified="2021-06-02" version="1">MTPLERRYRRLLRVLPADYRADREEEMVATLLDDRTDELDREHGWPGWGEFAATVALSVRVRFAAGTRIGGVARTVALVGLLGQVVLAAQSLTVASLVEGARPLPWFDIAAVVAFAALVTGRRTTARVAATLGAAVSLVPVVTALVRAEPGWLAVVFAVPSLITAVAMHVGHHREAPLPEPVRWWWAAATAVVLAVAATVPDPGAAWQFPAAWLLTLVAVAVVRPRVTLSPVPGSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T604</accession>
    <name>A0A7W7T604_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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            <taxon>Pseudonocardiaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
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            <end position="257"/>
        </location>
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            <end position="127"/>
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            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="26489" checksum="C427DC76B9576A32" modified="2021-06-02" version="1">MRIVLLVLGFLLLAAPPASAHAGGLRPSDRVARVVAVEPPLPGVAVDMVNHGTQIEVRNHGTGAVTVADRVVEIGAVVRFADERTTRVAWEMAIGPSVIKGVAEPAPGPNPLWWAVIPALTLGGWLLGRSRALLAIGVVVVASAHVWHAIGSTLVVVGQSFVPLLISASGVGLVCWPLAAVAVVTAVRRRPATAFVAAIVGAMLVVAGIPDLDSFRFAYLPFAGPADLDRLLVALTLGGGLGLAVGGFARMRRETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K1</accession>
    <name>A0A7W7T6K1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
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        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
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        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="616" mass="66761" checksum="EF7D0A6DE9D5C9F2" modified="2021-06-02" version="1">MSGSRSERRGVRFTLLGTVDVTVAGERIDLRAAKLRTVLALLLLGRGSLVSDSRIAEMLWGHTPPVTADAQIQTYVSRLRKILGETCTITRLRPGYVLDVGPARLDLVEFERVAAAGRQAAAAGRTAEAADLFARALGEWTGPALAGVTDCLEAVAAPDLEERRLVVLEERVAADIELDRHGGLVAELTGLVGANPLRERLRGQLMTVLDRTGRQAEALSCYHEHRRRLAVEMGIDPGAELREIYRRVLASTPAKPARPLPRTQHQVPAQLPPDIADFTGRTDHLATLEALLRPDPDRSSAAAAVISGMAGVGKTALAVHAGHRLRAGFPDGQCYLDLRGTSAPVRPHDALAKLLTGLGVPARDVPSDVDERVRLYRSRLADRRVLVVLDNAVGEQQIRPLLPGNPQCGVLVTGRARLSALPGVPVVDLGVLSQAESLELLSRIVSKQRIQPDPRSAERIARLCGGLPLAVRIAGARLVAKPHLRPVELAGRLADRGRRLDELQLADLDVRASVGLSYRSLGTGARRAFRLLALLERATFSVWNAAVVLDVTVGEARELTEQLVDARLLEVPDQDRYAYHDLVRAVAMELVAEEDLAVDRFAALHRAHASMEYSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6M1</accession>
    <name>A0A7W7T6M1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="41767" checksum="576A4EAD02FC773A" modified="2021-06-02" version="1">MDVGVIVDGKENGSDGSGRNSWQVRYFRDDGTIGSKSGFRSEDEAKAEARRIDDIHHGSTSTDNPPAKSGAAPVVVNDWIDLWFDGIDVAPTTLAQYERLAQYESLTRNHIRPRWGSGHLVDIGNLAAHTWAAELRSGGLADSTVKTIMKPLAMILADAADENLLDHNPIRPRRRRRHHRTREIVWDQPHQALRVALQAASLVGPWAGVLDITAAWTGARWGELTGLRRGNLHLDDGRFVIDPDVGALHEIDRTLQLGPPKTAESARTVTLPPFLVELLRLHLDTHDHPHVFVTEHHALLRRSNFSRRAMRPAADGNLHSSSPRVRVHPVAPEIERRILDTLQQRWIDALAGLGATSQPDLLAALPSVSRPMTEGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W7</accession>
    <name>A0A7W7T6W7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="110"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="28570" checksum="DAEA96AA6A78FC8C" modified="2021-06-02" version="1">MGNDEVPLHGGNMSAGVVRVGRTVRRPSGPWTPAVHALLDHLHAVGFTAAPKPLGIDDQGREVLSFVPGDVAWPEHFGLLDPDDRLARVARIVRDFHDAVADFVPPPDAHWQVLIPADGADIIAHHDLAPWNLVVGDPHWAFIDWDTAAPGTRLWDVAYALHGFVPLSADPEWNRADAGRRMRVFVDAYGLDETRRRELVLLLAARTRSMSTFLAAQAAVGRQPWTRLWHEGHGEAWQADADYIDQRTREWENALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7H3</accession>
    <name>A0A7W7T7H3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">F4559_005289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9191" checksum="29059F9029575C6F" modified="2021-06-02" version="1">MAHKKGASSSRNGRDSNPQYLGVKRFGGQVVKAGEILIRQRGTKFHPGVNVGRGKDDTLFALAAGAVEFGSKRGRKTVNIVPVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T859</accession>
    <name>A0A7W7T859_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar assembly protein FliH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="2">
        <location>
            <begin position="87"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="22845" checksum="B8D35BED089265EB" modified="2021-06-02" version="1">MSSSTEHLSTGTVLRDVETAVPYRVGPRGVPTIGTVRAGAHAEGYAVGWAQGIREAREATSAARARATSDLTTLLADRDARIGRAVAAVAAAADQVRAITVQRAEEIAEPLVAAAVDLAESLLGATLAVDAPAAARAAVRRALANVPERKPVVVRLNPADLAELAEAETPTLSGAPVSLAADPSVGRGDAVAETDTTTVYAVLAEALAAVRAELGALTTSLREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8G4</accession>
    <name>A0A7W7T8G4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033850">
        <property type="term" value="F:Z-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="83"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="29397" checksum="B660391F87D6F36F" modified="2021-06-02" version="1">MGVREHVKHVLLKGYEFRLNRWLAGKQRPRHVGVVLDGNRRWAREAGFEDVAHGHRAGARKILELLAWCREAEVEVVTLWMLSTDNLDRPAAELLPLLDIIADIVDEIAEPGNPWRVRHVGALDMLPTETAARLSAAALRTADRTGLVVNVAVGYGGRQEIADAVRKLLQKHAESGGTIEELAEVLDVDHIAEHLYTSGQPDPDLLIRTSGEQRLSGFMLWQSAHSEFWFCEAYWPEFRRTDFLRALRDYAIRHRRFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K6</accession>
    <name>A0A7W7T8K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity iron transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="29014" checksum="63BD05280FD9A5EA" modified="2021-06-02" version="1">MLVSNGLIGLREGLEAALVVSILVAFLVKTDRRDRLPFVWLGVGIAVVLSVGFGALVTFTTATMTFEQQEAFGGGMSLVAVAFVTGMIFWMRSTARTIAAELRGKMDQALKVGPAAVVVLSFLAVGREGLETAVFFYSSVQSAGVGTTQPLIGFVVGIAAAVALAYGLYRGAIRFDLGKFFTWTGALLVFVAAGVLAYGLHDLQEAAILPGLNTLAFDLSDTLPEGEWLGALLKGIFNYSQRTSVLQAVAWVAYVAIVLPLFLIKPRSRAAGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8M8</accession>
    <name>A0A7W7T8M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="384" mass="41676" checksum="6A2CC1EAE8B30D2D" modified="2021-06-02" version="1">MNAPHQVAVGVLTGGGRPERVITTIADELPELFATQVNGQTWWRAEHEVDQLPLDENGDIPMRTLSQRHRQDRGWDLLVLVTDLPRRAGTDPVVAGVDVEHGVAMISLPALGAVLVRRRARALLVRVVRQLVSRRSGVDGGHGGHGTAARLREVPAPTPRMPGERQSSATHLTLVGLRGRLRLLAGMVRDNRPWRLVPHLAGATAAAAGTAAYGIVTSSFRQLADALSPLRLAAITVVTILVMTAWLTAYNHLWDRPSESAGRRKALLYNGSTATTLALGVACMYAILYVLSLLAAAVLIDSGYFAQSLGHSVGVGSYLNLVWLCSSVGIVAGSLGSSLEDEETVRNATYGRRERERQERNRRRRDDRISGERENPTQAARSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X8</accession>
    <name>A0A7W7T8X8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21569" checksum="859D7E384F275E65" modified="2021-06-02" version="1">MIPKTIKVLLVDDHPVVRQGVRGMLAAAEDITVVGEAGSGADAVARVPELSPDVVLMDLRMPGMDGVEATARIADRCRVVVLTTYDTDADILRAVEAGAVGYLLKDAAPEDLLDAVRAAARGETVLAPAMVRKLVVRTPALSPREIEVLRLVARGLSNAEIGRELFIGEATVKTHLLRVFNKLGVSDRTAAVTTAMERGVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9F7</accession>
    <name>A0A7W7T9F7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="4">
        <location>
            <begin position="345"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="722" mass="77918" checksum="0B08158DD5A4973F" modified="2021-06-02" version="1">MSAPEFDASGDLPDNVRPLRATDDTPHAQVEPVADVLDAELVEDDQNRPVVLVDSDDVADDSTWLTRLRHQTRQAIIPAYLSDLDQIRQTATWVTRHYAHATAYHAVRAPMYAVRLAVRSPRGALLLLAATGRWATDAEGRPLRRQMVVQNDADKYLRLVAERNARVRARGLLLAVGVAVGVPLVVLLPSLAPAWVMGLCWALTVGVLGAVGSPADKPVATRAVVGAQVAKLTSDLVVRALTSLGISGISKNPDAIGFTSPIHRDGPGWRADVELPGGVVAADVVERRDRLASGLGRALGCVWPEQTPGGHPGQLTLWVGDRDMAKAKQPAWPLRTGRKVDLFEPQPFGTDVRGRWVEVTLMYVAALIGAIPRMGKTFTLRQLLLTAALDPRVELHVYDLKGTGDLSPLGPVAHRYRAGDDPEDIGYAVAALRALREEMRRRTKVIRELPKDLCPENKVTSPLASKRSLRLHPIVIGVDECQVWFEHPEHGAEIEEICTDLVKRGPATGIVLILATQRPDSKSIPTQISDNAVLRFCLKVTGQMANDMVLGTSSYRNGERATQFSFSDKGIGLLKGVTDETTTVKGVYIDGPGAEALAARARVTRTDAGLLTGYAAEADVQVEEGDVTSTLLPDVLTALGGADKAWSESIVDKLVELRPSVYSAWASQDGADKAKQLTAALKPYGVGTVQVWGTDPVTGKGANRRGVHRDDVTAIITESDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9I9</accession>
    <name>A0A7W7T9I9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">F4559_006354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4968995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="353" mass="37316" checksum="A77AF71262AE7571" modified="2021-06-02" version="1">MSPVLALVGATGAVGTVMIDIINGRSSVPWGEIRLIASARSAGKKISVRGQELTVIALSPEAFDGVDVAMFDVPDEVSAEWAPIAASRGAVAVDNSGAFRMDPDVPLVVPEVNADKIGERPKGIIANPNCTTLSMMAALGALHREFGLRELVVASYQAASGGGQSAIDRLYGEIEALAGKQVGVRAGDVREVLEAAGLPVSDSPFPAPLALNVVPWAGSLKEEGWTSEELKVRNESRKILGIDDLKVSATCVRVPVVTTHSLAVHATFEREVTVEAAHKIFAAQPSIVLVDDPTTKTFPTPVDVVGQDPTYVGRVRQALDFPNTLDFFVCGDNLRKGAALNTYEIAEELANRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9L0</accession>
    <name>A0A7W7T9L0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="517" mass="55654" checksum="EF467D89464CD5F6" modified="2021-06-02" version="1">MGNQWPPAPFDQAAAKMREWNAWYVGRAEQLAALYGSGPVVHTRPGQYRGGLVGAVSRFFWGRPVSPRGQQRTRVHVPLAADIATASADLLFAEPPRVLTEDTAAQARLDQVVNTAETHSALLEAAEVAAALGGAYLRVVWDGDVRPHAMLDAVDADAAVPDWRWKRLVGVTFWQTVGTDGPTVLRHLERHEPGRIVHTLHQGSDDELGRAIPLAEHPSTAWAAELVDAEGAIGTGTQRLTAAYAPNIRPSREWRSIPALRPLGRSDLDGVEPLLDVLDEVYSSWVRDIRLAKARLIVPTGYLTPNGPGQGATFDDDQEVFHELNMLTGRGDGSPPITPSQFAIRVAEHQATAQQITHDVLRSAGYSTSTFGEINGRATGITATEVTDRRELSETTRDKKSRYWSAALGPLVGSLLDVDAHVFGTRGVTGAEPVVEFGDQAQPDTGELARTAHALLTAEAASTEVRVRLVHPEWTGDQVDAEVGRIFAETGRAVPDPATWRGTQDGGTNDGVGAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Q2</accession>
    <name>A0A7W7T9Q2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator MprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="26123" checksum="D3DD137FDA810E3D" modified="2021-06-02" version="1">MRILVVDDDRAVRESLRRSLQFNGYQVDLAGDGLQALESVVDQRPDAMVLDVMMPRLDGLEVCRRLRSTGDDLPILVLTARDAVSDRVSGLDAGADDYLPKPFALEELLARLRALLRRAGPDDQDDERKRSVLRFADLELDPGTRDVRRGERPISLTRTEFALLELFLGHPKQVLTRSRILEDVWGYDFPTSGNALEVYVGYLRRKTEAEGEPRLLHTVRGVGYVLRETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA16</accession>
    <name>A0A7W7TA16_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recF</name>
        <name evidence="10" type="ORF">F4559_006639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4969280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40555" checksum="ACA6B1C0E594076B" modified="2021-06-02" version="1">MYVRHLQVADFRSWEHADLAFEPGVSVLVGRNGQGKTNLVEALGYVATLGSHRVATDAPLIRHGAPRAVVRTAVVNDGRELLVELEITAGKANRARVNRGPVPRPRDVLGILRTVLFAPEDLALVRGDPGERRRFLDELLTSRAPRYAGVRADYERVLKQRGALLKSVRSTRSSDIGTLDVWDGHLARHGAELLAARLDLVADIAPHVTAAYAEVAPESRPALISYRSSLGEAYPDSHDREVLEDALLAELHRLRGQEIERGVCLIGPHRDDLDLALGELPAKGYASHGESWSFALALRLGGYELLRSEGTEPVLVLDDVFAELDRGRRAQLAKVAAAAEQVFITAAVAEDVPEELVGARFVVDDGEVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA28</accession>
    <name>A0A7W7TA28_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="15075" checksum="688150FF6B6B9791" modified="2021-06-02" version="1">MAKYLLLKHYRGAPEAVNCVPMDQWTPEEISAHIRYMEDFADRLRETGEYVDSQALAPEGLFVRYDGEGRPPVTDGPFAETKDLIAGWMVIDVDTRDRAIELAGELSAAPGAGGKPIHEWLELRPFYGVPPTITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA61</accession>
    <name>A0A7W7TA61_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase_M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="119"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="827" mass="88775" checksum="307399450C57EA10" modified="2021-06-02" version="1">MPTGTTLRFTTFALLAAATTLYVFGIYASVWPTTAGQEGLRCQVRSGLYLTASSSVDPDEGKWSRYRECMSAMLGARAAWLLGGLLLLFVVALVIYLVRPAWRIRRSRLVPLEGALADELRDTLAALVAEAGLRTAPEFVLDPARFRAGGVAFGNHRRKVVCLDAGLVALHRRDPESFRALVLHELAHVRSDVTTTYATLAVWRSFLAVTLVPFVLISLDPMLLSRTPWRLALDFSLPSGAVGARLAALVLLVFLSRIAVLRSREKYADAMVARWTGTDDPYRNLRPTRSIRRWLAVHPTRAGRLAAMRDPDSLSRPGFLETFTSALAVQIAWWHTVSGLQDLTWYHADNASMPVMRIVWAIGAAVLVGTVAWRGAAYLRTAGQSRRGVFALPGLALGLGFACGRFASAWGVGPVKPAGVVASIPLVCVALLVCCWVGHCATLARTRVHGVLIGIAAVVVCFVTLGWFSELQAADKFWRGYMVPYLDLLHGYATSDVETVVLDVVVVPFLLNHNRVPTVAALVLVWLVPLALRRELPRPAVGLGLVGAVVASTAILLLGSSDDPPQALVLTAWGVLLVVGVQLAVAIVVARRSGRVAALLATWLIGLVATVALWFAHLDGTVVDSVVAARPHQVLPVLGTIAGLVGGLAAGGGGRRTGQARPVRVALIAVVSVGLASWWPHSDGKAPLEASPAVWEIDYDFAVAVWAQGGGWDQFTSVVQGNSRFATALDSGNDTAVADTCEAQSAVLRDAREFPPPPEDHVRDEWIDALDTLANATQACLRVLREGDTDVDGMLAQFLRGLDRLKAAQELILAARERALANPPDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAC7</accession>
    <name>A0A7W7TAC7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12449" checksum="88110377CE5A3AED" modified="2021-06-02" version="1">MGEQFKVEPGELRGYAELLDRNAQHFLTIKQHAVTKGGDTAGFTGVLSLLQPVVTGVANLYGETLDFANSMMKREAGSLNQAADYYEQVEALAGSILDRVFAQLAAASDAPTLGDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAJ2</accession>
    <name>A0A7W7TAJ2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1524 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031449671" description="DUF1524 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1524" evidence="2">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22124" checksum="5B0A94C1EB100EEE" modified="2021-06-02" version="1">MRKTVTSLLLVGALGLATAAPASATPPNIPSTATAKSELAALTVAAEGSLTGYSREKFPHWITVSGACNTRETVLKRDGSNVVTDSSCAATSGSWYSPYDGATWTQASDVDIDHVVPLAEAWRSGASSWTTDRRQSFANDLGNPQLIAVTDNVNQSKGDQDPARWKPPLTSYWCTYGKIWVHSKYRWGLKVDSAEKSALTGLLDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAM8</accession>
    <name>A0A7W7TAM8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="211" mass="22467" checksum="BBC35515FE2886CE" modified="2021-06-02" version="1">MTEPEYLTLARTAYDTVAEDYAAMLRDELARNPHDRAVLGLFAELVSGKVVDAGCGPGRISGHLAGLGVDVHGVDLSPAMVGVARREFPALEFAVGSLLELDEPDGALGGVVAWYSVIHVPRELHATVFAGFHRVLAPGGLLQLAFQVGDISRRLEQGYGHEIALDVHRLRPDVVAGQLVDAGFTVVSTVERAAVAPEKAPQAYVLARRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT07</accession>
    <name>A0A7W7WT07_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein YczE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="21945" checksum="9B7F7C2165A885EF" modified="2021-06-02" version="1">MLAALTQVPVTVRPVRRLPQLIAGLWLYGACMALQIRATLGLDPWDVLHEGLTKLTGLSFGTITALVGVVVLLCWIPLRQRPGVGTVANVLVIGVAVDVTLMVLPTPEGIVLRAVFLVTGIVLNGLAAAVYIGARLGPGPRDGLTTGFCRRTGISLRLVRTVVEVTVLAIGWLLGGTIGLGTVLYAVTIGPLTQAFLPLVTWVESTPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT52</accession>
    <name>A0A7W7WT52_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="28192" checksum="88D8F83D07E132F4" modified="2021-06-02" version="1">MAARSDRYGYREIADALRARIDSDGPDRLGPGDRVPGENEITAEYGVEQPTARRALDLLKNEGLIVARRGSGTYVRDFKRIRRVTPDRLRSSVWGGGESIWGTDVSQRPYVSEPTVAAERPVTPIADALGLTADGLAVVRRRRYLVEGKPVQLATSYYPEHLVKDSAITREDTGEGGAYARLAELGHPPVRFREELRARMPREEERVDLELAQGTPVVEIVRYAHAADDVPVEVTVMVLDGASYVLEYKFDSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT95</accession>
    <name>A0A7W7WT95_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="118" mass="13142" checksum="08EFB6517590ED1E" modified="2021-06-02" version="1">MTDVLDLEKIFSRDGFAEVVDGMVTDFAPRLFAVVQVRGDRLDGRVAAWGMAFPEHAEVVTTDGGMRMRVRDADSTVPAFTAQHEDLSASVVWLPAFNSRLDEPAVDQPEEDENGTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTK9</accession>
    <name>A0A7W7WTK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="25582" checksum="B13A4818E876DD8A" modified="2021-06-02" version="1">MARSTAPSPRTHQVQVPHRPTPGPVAGGTAVATQPAVPPPPNPDPPLSTTTSDRSRYRRSNSTQPPLHPDGRRTQTSRHRGSAAALSGLRRLLPTLTAASCHRCPQSRGTAQPPGKAARRATHIRPRRLLPLHHATTGIRCRHNRCRCRHNRCRCRCRHNRCRCRHNAAAVVAALPSQRRLTRGRATTAEHPACLRTGPHRAVPRNISVSSVVTATSGPPTSRHRLLSGTSTATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM2</accession>
    <name>A0A7W7WTM2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="29669" checksum="24870669C68FE466" modified="2021-06-02" version="1">MEDVPVMSIGEFARRSRLSPKALRLYERQGLLVPTAVDPVTGYRSYAEDQLDAARLIGRLRRLDMPLAVVGAVLAAPADARADLVAEYWAAVVRRIAVQSDLAAYLRSMLSEGKGLSAMYEVSSRAVPDQVVLTEQRHIRQPELSGWIGAAMSRLFTTALTDGGPSGSPFVIYHGEVTEDSDGPVEVCVPVAREVAGTPSRVEPAHTEAFVRLRKREVRYPQILGAFDAVATWVTDQGHPLTEAPREVYFADWEKIGPDDPACDIALPFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTM3</accession>
    <name>A0A7W7WTM3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="24704" checksum="9A5F4B0052201B80" modified="2021-06-02" version="1">MTTRRVLVVEDDLTIAESVAARLRAEGFEVAVAHDGPAAVKAADDFVPDLVVLDVMLPGFDGLEVCRRLHAVRPVPVLMLTARGDETDLLVGLAVGADDYLTKPFSIRELAARVHALLRRVDRVSAARRITLADLEIDLTERRVQRGGIEARLTPTEFQLLVHLAERPRAVQSRERLLSEVWGWQDGMGTRTVDSHVKALRRKLGTDLIRTVHGVGYALEVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN8</accession>
    <name>A0A7W7WTN8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="37" mass="3902" checksum="EA0071233E3B44A8" modified="2021-06-02" version="1">MSEQLVLVPPLSVVPAVVLPEPAVVPVSIAVPFTHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU70</accession>
    <name>A0A7W7WU70_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannose/cellobiose epimerase-like protein (N-acyl-D-glucosamine 2-epimerase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="594" mass="67753" checksum="23C191DD563E3B9D" modified="2021-06-02" version="1">MHSYSDTAFGRLESAWDGHFRLRLADGTSVDLHLTDTTSAQVVRNLGEPYHDVTGRLAELLATPGRLVFAHGPVYPDGRRQATQVTFVGEGADEHVFERPDWWIDQVRELARFYRRAQFGTGEVDYADYRTQIRLGGDKNGRHVQETDTISRLVYGMASAYMLTGDEDFLTVADRGSRYLRDHMRFVDTDEDVTYWYHGVDVDGGRERKLFTSEFDDDYHAIPAYEQIYALAGLVQNYRVTGDPAIKADIDGTMRLFERFFADPVLGGYYSHIDPVTLSPHHDSLGANRSRKNWNSVGDHAPAYLFNLYLATGDERHLRMLEHTFDMIVSHFPDRDTPFVQERFHADWAPDRSWGWQQDRAVVGHNLKIAWNLTRMGAALPKYDYARLADRLADTMPDVGRDPLRGGWYDLVRRQAPHDFVWHDRKAWWQQEQAILAYLVLAGHRGDAGRLAHAREAQSFYNAFFLDHDEGGVYFNVLADGIPYLMGTERLKGSHSMSMYHSAELCYLATVYNGLLVRGEPLDLWFRPRADADFPDRSLRVAPDVLPAGRVRLEGVLVDGEPYRDFDADAMAVRLPDSAGPVTVRARLVPVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF0</accession>
    <name>A0A7W7WUF0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PurR-regulated permease PerM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15544" checksum="5705A1855A2C5041" modified="2021-06-02" version="1">MFLVVFLTFGGVLTLFALPLAEQGTQPATRLPDMIADLRGGRSPVGTPLERTNALEFARDNEERIRQFATGLGTPALNLLRSAVTGVVATISIFVPAYLAVPQGHKVINGTLVLFPPQRARRIHRVGRERGRPSPATSPATCSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUH0</accession>
    <name>A0A7W7WUH0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11704" checksum="19B53561477237DE" modified="2021-06-02" version="1">MADDLTPEALAEWLADVPDLDLLATQGPWKWFPLRIAYEDGKCGFSGMRVWPGTAVVDVMATRGPDDATAHRRDGEHATWHHDGTLADAVAGLLALPEPQPEPDHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUL3</accession>
    <name>A0A7W7WUL3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnD</name>
        <name evidence="10" type="ORF">F4559_001291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="421"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="604"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="710"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="776" mass="83743" checksum="1F04F4D22B631392" modified="2021-06-02" version="1">MEHIEPAVVTADDLVRARDRLLGPGRRRLTGEALREALVDLHEFWLAAHAAQSGVDGPGVALVAVGGLGRCELVPYSDLDLVLVHTGRKDVKAISERLWYPLWNSGIGLDHSVRTVGEALRVASTDLRTATGLLDLRYLAGDTEVARRLADSARQAWRAGVRTRLDEMTESARRRWVRSGEIAHRVEPDIKHGRGGLRDLTLLDGLAIAQLIDRPGVDVTDARALLLDVRTELRRVAGRPRDVLRAQDGDEVAAALDLPDRFALARALSSAARTVAYSVDVALRTARAAVPKRGLFALRRTPTRRPLDEGVVLHGNEVALARDAHPARDPALLLRVAGAAARTNHPVAPGTLARLADSAPELRKPWPREAREELLSLLGAGTGLIDVVEALDRTGLWGRLFPEWGAVRDLPPRDAAHMWTVDRHLVVATAHASRLATRVSRPDLLLLGTLVHDIGKGRQADHSEVGAALATQIGERLGLWPHDIRLLTAMVRHHLLLPHTATRRDVEDEATVHRVVETLDGDPVLLELLHALAEADALATGPGTWTDWKASLMADLVHRCRTAMAGDPLPGPEPLDDISRTLATTVVTTGRPDVVITTTDGTTTVTVAAPDRPGTLSRAAGVLALNSLEVHAATLRSYEGAAVDAFTVSPRFGSLPDVALLREQLSRALDGSLSLPEKLAAKERDYGGPPADAPPAKILWFDDESTGAVVLELRAPDRIGLLHHVADALERCGADIRWARVATLGSTVVDSFALTAPTLDPDHRARIEHAVLQAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUM5</accession>
    <name>A0A7W7WUM5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24393" checksum="C189D819AF9BE323" modified="2021-06-02" version="1">MVDAPATAVLVHSPYLGPASLRPLAGALAALGHPVLLLDLRVTVNAAPVHQRLIGSFADAVEDSLVEGELVLVGHSGAGPLLPAFADALETPVTGLVYLDADLPTPGRSWRDDASVAEMNRLKSISRDGLMPRWDLWFAPEVLAAMVPDVRQLEEIAGEAPEVALAFLKEQRPSVEWSGPSTYVRLSAAYADAAAKARAAGWPVVELDTHHLAAATAPDEVAAALVRVLRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUZ1</accession>
    <name>A0A7W7WUZ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024341">
        <property type="entry name" value="DUF2631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10939">
        <property type="entry name" value="DUF2631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9375" checksum="055EE383DF6B1A17" modified="2021-06-02" version="1">MSSSSEPRPAVDTHDEPSAAWGWHGTFPKGIRIAGWLSVLATFSLLIGNHHGRTEDLYIVAFGGGMAILLIWEQVRSRTSWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVZ9</accession>
    <name>A0A7W7WVZ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase</fullName>
            <ecNumber evidence="4">6.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="50"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="455"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="559" mass="61241" checksum="C1B74ADAEDC4FC45" modified="2021-06-02" version="1">MADEPDATAVFRAARDLLLATSDDHDAACAAFEWPLLERFNWALDWFDVIARDNDRTALWIVAEDGTEGRWSFAELARRSDRLANHLRAHGVRRGDRVLLMLGNRVELWETLLAALKLGAVVIPATTLLGTADLVDRVTRGRVRHVVTSEPAKFADVPGGYTRIVVGDPVPGWVDHAAAADAPDLFVPDGETRADDTVLLYFTSGTTARPKLVEHTHASYPVGHLSTMYWIGLEPGDVHLNVSSPGWAKHAWSNVFAPWNAEATVFVVDYARFDAERLLAEIDRCGITSFCAPPTVWRMLIQADLGTVRTPPRKVVGAGEPLNPEVIERVGRAWGVTIRDGFGQTETTVQIANTPGLPVKPGSMGRPVPGYPVVLLDPVTGEPAREGEICLDLSRRPLGLMVGYHGDEERTAEVMRAGHYHTGDVGSVDDDGYITYVGRTDDVFKASDYRISPFELESVLLEHEAVAEAAVVPAPDPVRSAVPKAFVVLARGFAADAGTAFAILRHAREHLAPYQRVRRLEFAELPKTVSGKIRRVDLRGRPTGGPGEFREEDFPDLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW65</accession>
    <name>A0A7W7WW65_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YndB with AHSA1/START domain/DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="260" mass="29135" checksum="7D8D183A7FF7A221" modified="2021-06-02" version="1">MDEVFRALADPSRRALLDRLNARSGLTLRQLCDGLDMTRQSVSKHLAVLAAANLVTTRWRGREKLHHLNAEPINAIADRWIGRYDRARVHALADLKLALEQEPMGANRFVYTTYITTTPERLWQALTDPAFTGRYWGATFTTDWTPGASMTWHENGVAIKDPEQVVLESDPFHRLSYTWHALTDEWTASHGFDPDVVARMSAEPRSKVTFELEELGARVKLTVVHDGFEPGSEILAGISEGWPMIVSALKTLLETGDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWL2</accession>
    <name>A0A7W7WWL2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-4-amino-4,6-dideoxygalactose transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="38477" checksum="F64B46ECFB2B15FB" modified="2021-06-02" version="1">MHNVPFHAQSDTFSQLWPITRQHVADVLELEPGRKVAELEKALVAYTGRRHAIGVNSGTDALVLLLRAAGLRPGDGVVVPAFSFVASASAVVLAGGRPVFADVEPGGYGLSPTSVRAVVTADTRFVLPVHLFHRPADLGGLLDVANRLRLMVVEDCAEAIGMRWAGRHVGAAGVGGALSFSPTTTLGALGDAGAVLTDDPVVAETAATVRHRGLGDQPGLDSRMDDVQAAILLAKLGRLESDVRRRIALARHYSRRLADVPGLTLPVSPRRAGLRGVPCQYVVETDDRAELAAHLASAGIGAEPRHPVPLHLQPCFADTGHRPGDFPHAERAARRTLALPLHPDLTAADADRVCDAIAAFGRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD8</accession>
    <name>A0A7W7WXD8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA reductase-like NAD-dependent aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="66"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="526" mass="56489" checksum="5838BD41146DC44B" modified="2021-06-02" version="1">MRFGLYPAYIGGRDVFGDNVRYVHTISARALLTDTFPALRAKQDLDRGLVTPDEVGDIAVGACVVADDLLADAALEAAAGAQPAWARVPVGERVEIGLRIARRILEHLDPLVEILVEEGVPRSAALGMVGGIPHTSWSAETIRWCAEQLEVRRSDGNRDMILRRLADGVVCINPPQNAATPNALNGLIALLSGNTVVVRAPRGVALSCMYAMREVVAPVLEEFGAPPGTLNAFCGAPSLDKWLASEHVDDVLYFGGSRKGLEFERDAIAAGKKPILELAGNDCCVVWHDADLDAAVETITQFFLNSGQICNVPNQVVAHPAIADELIRRLVEATRVITPGFPEDPDVVLTPVLGADWFTGCLAEALTKGARLVHGGRRLEVDGTPSDTGYFVEPTIVRIDGLRDARSLSVVRDETFFPLLPVIVPEAASDEDLLEEVLEFVDGNAYGLRNSFWSTGQAAIDRFLAATRNGGNLRVNDSHSGFLPFLPNQGGPGLTGGVFGEASHPMLRTTHYQAVSVLRPSSEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXI5</accession>
    <name>A0A7W7WXI5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_004516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="300"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4967157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="493" mass="53939" checksum="D2239F627CD0462E" modified="2021-06-02" version="1">MSEQVQPTRRRPVVGAVPTKRMTSPTVNGWEPAYRYGVIAADVLCTVVVVALSGVLLSANHLTFGPLPLLALQAVTILVVIASLYVNRVWNTSVLGQGAEEFRRLGRGLVGAVVVLGLGGLAAGLPGARLWVFLVGPAIALVAFPVRYLLRRPLHRARGEGRCLLPVLAAGNVDTVKDLIGRTRRAPHLGWRVDAVCTVDGRAEIGVELDGIPVVGRFNELAEQVRRGGYRIVAVTPDAYWTPRRLQQLAWELEGTGTEMVVAPALMDFAGPRLHVTGVLGMPLLRVSEPTFTGIRRMIKLMVDKFGSLLLLALLAPVLLTVAVAIMIDTRGPVLYKQRRVGKDGRQFTILKFRTMVTDADKLRAELEAVNEGAGVLFKMKRDPRVTSVGRVLRRYSMDELPQLFNVFGGSMSLVGPRPPLPEESAKYGPDMRRRLLVKPGMTGLWQVSGRSDLSWDESVRLDLRYVEDWSLALDALILWKTIRAVTGGAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXN4</accession>
    <name>A0A7W7WXN4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized SAM-binding protein YcdF (DUF218 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="24371" checksum="CB7D8776B1B0EC11" modified="2021-06-02" version="1">MPSSAIPAEHRADVLTLWDYHDMKHQVHPADIVIALGSHDIGVAVRAVELYHHGTAPRLLFTGANAPTTIKRFPRGEAVHYRERALDNGVPDDAILIETKATNTAENFTLSREVLRDNAIEVRSAVIVSRPYQERRSYATCRKLWPELEITCTSHRPPIDEYAAGIGDVDFVISMLVGDTQRVTVFADAGYAISQEVPAEVHEAFERLVTAGYTSRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXV9</accession>
    <name>A0A7W7WXV9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005065">
        <property type="entry name" value="PAF_acetylhydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PTHR10272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="472" mass="49954" checksum="C9637574DF9385FB" modified="2021-06-02" version="1">MTELITGLHMSPLELLVLLSAAVLVAARWLPLPARPRVTVVTAAVFLLSAITLVVAGPRWQLVPALAGAALALPFALSPVLRRGPARRARWWLALPGTLACAGLVVTAPVAAWAFPVPEFPVPSGDHAVGTRVLEWTDPDRPETFTEDPGDHRTIVAQLWYPAEDVAADAPRAQYLGRTEAEAHTVAEAIAGGVGLPGFLVDGVPRARTHAVPDARVADGRFPVVLFSPGAGGVRTQNTAWAEELASRGYVVAALDHLYDSAAVVLADGRMITTKTISSGDRDQDEKLAADWTAIRAADLVSTLTHLAGPTPLSDHLDLTRTAVTGHSMGGAAALQAARQDRRFAAVIDLDGYPHGPTTPDLTQPALALTQTVTPDTDPRYLSRLTEALTHSTGKSYRLTIPDTAHLTFMDGPLYLPPVPSIVGSLGRTESPRVVAATTLAFLDAVLRDKSTDLNATLSTYGDLTVHEPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXW2</accession>
    <name>A0A7W7WXW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YxjI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="22140" checksum="81D1CDA7B243DCDB" modified="2021-06-02" version="1">MQPPAAIHLHQKITMMVNRYEAFADDGNGQPGVPIAFVEQKRMKLKEHVTIYTDSSKSRVLAEFRARKVIDLGSGYDVTTPEGQAIGLFRKDFGKSLVNSTWHVEQPGLAPFTGRERDQGIAVLRRVWGFIPFVNNIPFPFRYHFDFARENGPVFSVDKKTWVRDHYLIRILDPNVDFRLVIAQAVAVDALQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYA6</accession>
    <name>A0A7W7WYA6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="22158" checksum="80E5EDAE7B712D0B" modified="2021-06-02" version="1">MRIAELSRRTGMPMPTIKYYLREGLAHPGERLSVNQTSYDETHVRRLTLVRALIEVGGLSIAAAREVLRSLDSREALFTVLATMQNHLVTPVEQSAETVADKARDRVRTLVAGRGWHVDLDSPPATVLVDALATLDRLGHHDYATILDTLADAGQRVAEAEVGAVVGREDQDVVEAAVVGTALGGVVLNSLRLLAHQHASATAFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL0</accession>
    <name>A0A7W7WYL0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-methionine transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="227" mass="24164" checksum="9450D7FE4334472A" modified="2021-06-02" version="1">MRKSTPWSTVFDDLLVATGDTLYMVAVSTLIATLLGIPVGVWLQLTAPGGLKPRPVVHRLLGFVVDLGRSMPFLVLLILLMSLTRLLLGNTIGASAAIVPLSIGAIPFVGRLVQNVLSEVHVSVVEAAVTTGASTLRIVRSVLLRESLPALINAIGVTAIALLGYSAMAGVVGGGGLGDLAVRYGYQRFDDRYLWSTVIVLAIFATIMQYGFNRAARAVDRRRHASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYP1</accession>
    <name>A0A7W7WYP1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030752780" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="42"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="174"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="223" mass="23263" checksum="B9E8AD80F388FEFF" modified="2021-06-02" version="1">MASNRGKHRPTSGTTRTIARFAVAGVIVGAPLALAAGTAQAQGSGVNWDAVAACESGGNWSINTGNGYYGGLQFSPGTWAANGGSGQPHLASREEQIRVAENVMQTQGIGAWPVCGPRGLGGGASAPVQQRPAPAPQQPRTPTAQQQQQQQQYQPPVQQSAPVVVALPTTNPEGDYEIKAGDSLSKIAGELKIEGGWQKLVELNKEFIPNPDLIMPGHKIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV4</accession>
    <name>A0A7W7WYV4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chemotaxis protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="155"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="31242" checksum="A3C089BE267DBC41" modified="2021-06-02" version="1">MSGKKKGHDEEHENHERWLLTYSDMITLLMVLFIVMFAMSTVDAQKFDQLKQSLAGAFGGSEIVVVGEISSKGTNDESLLPSAVDLSTGGVANDKPISEDQAAAAVREADRAKASQDEQKARDEVDSLRGIQQRMTEELTKQGLADQVAFSIDDRGLVVTVITSSIVFGGDSAVLLPDGRRVVMALEPTLVDLPNKLEIGGHTNQLNVPTVNYPSAWELSTARASSVVRVLAEAGVSPSRMTATGHADQKPLYPPSDPLAVTRNRRVEIVVMSGQSPEVRSLLPVIATHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYZ6</accession>
    <name>A0A7W7WYZ6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S1-C subfamily serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="41344" checksum="60E003101FE86267" modified="2021-06-02" version="1">MNWVDVLVLALAAFAAVSGARQGMVVALPAFVGVLVGLVLGTQLAPLVVSRFDNVVTKVVFAVGIVVLLVALGETLGVYVGRIIKARVNASPLRGADNALGAVVQGAVVFVVAWMIALPLTAVAGLPSLSKSLNQSVILSTVDDAMPQAARTLSQDLEALFDVSGFPSPTNPFDDTPLRNVDPPDAALAANPIVQKLRPSVVKVRGRAPSCSRALEGTGFVIAPHRVMTNAHVVAGTNEVSIEVGVGQFDAVVVHYDPRTDVAILAVNDFDATPLAFRTDEINQGEDGIVLGYPLDGPYTPSVARVRERIPVLRGPDIYDGQTVERDVYTIRAKVRSGNSGGPLVDPQGRVMGVVFGAAVDDQETGFVLTAQEVADEVAKAPELTRQVSTEGCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X053</accession>
    <name>A0A7W7X053_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="44826" checksum="24C681F78C2F5FEC" modified="2021-06-02" version="1">MGDHRWRGYTHPELHTMINAGPGVAASRPIEDGWKALSETLADIDESIKIGLDKLGATWEGSTADAATAALSPLAQWAADAKQGSDVMKTSAQLQGDYIADARKEMPEPVPVTTAAPSTGDKILGFLGGPSGIAHVVQQQQDHERQEAAQDNAEAKAVQVMNTYQSSSEWNSGTLGEFVPPPKVVIDTPPPATAGEYNSSSANYNTPKTWSAPTDNSGTTNTSWAPPPTGPTVSPVYTPPGNGGGVTNPVWAPPAPTPGPPVTPLPPPVGGPNPTPTPPPVWQPPTPGPNPTPPPGTGPKPPPVGGPGLKPGPAPTPGGPRPLQPSLRPMGPGGGPNPFGPNGQGGLRGGPGGFPGGPGGFAGQGGPGQQLGRGGMAGAGAFGMNAPGAGGPGGASGGRGGAAGAGGMAGGGHGGNGDEDIEHKSADYLVETTDVFGDDRLVAPPVIGEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXR6</accession>
    <name>A0A7W7SXR6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="151" mass="16771" checksum="A0B33C94AD77EEFC" modified="2021-06-02" version="1">MSVATEAALIRDLFAQVEDIEEVAFTLSADDERRSKLTDVVERVLSSAPPVRPVVAGELLDLTEKTVKAWAREGVLAVHSESPRMLLDAVRLHEVMHVVAELRRAGKTRGLLDEVHRRLSDAALVERPDLVESIAQMNRGEGRVVRTGWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYE2</accession>
    <name>A0A7W7SYE2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein YbaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="17912" checksum="A5FCC5A8FD16E715" modified="2021-06-02" version="1">MEPERMIADLEARARDLAQRSQEMQEQIRQVTATVRSPDGAVTVTVAPNGAVQGIDFSPRAVEFSHVQLGQVVMATLRRAQAQAAQQVAAVVEPQFGGTAAMDFLTSFIPQVEEPPPAQGDDGSFLRSDSWDARPPQRPTPPQRPTPPRPGRSDDGDDDFGPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYL2</accession>
    <name>A0A7W7SYL2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (DUF433 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007367">
        <property type="entry name" value="DUF433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04255">
        <property type="entry name" value="DUF433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="216" mass="24432" checksum="F1FD3C02C88197F1" modified="2021-06-02" version="1">MVDRFTDPLMTPKEAARHLQIPHTTMYYWLHEQANGSPLVHQVNEAKRGRPSVPFVAVVEAYVLRSLRALGLTKAKIRDTAAAVRREFGTPYGLATRRIATDGIDIFIHYADDQLARAGDGQRPIREVIDDYLKFITWENGDDFPARLRLRQYPDVAPVIIDPQFGWGTPVVESTKVPVHAVVDLWRAGESLDDVAYEYDMTREQVESICRVANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYL8</accession>
    <name>A0A7W7SYL8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="SSF48619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="703" mass="76194" checksum="F601ACCD944AF546" modified="2021-06-02" version="1">MGVGAVDRHGRVGLRVLDRLPAWFRFVLVTLAVFVCGVIASRPAGAADDRPLTGDVADAARAVGRMTAPDRTTDPLAAFPADFDEVTGRDPRTITAPDGTLRAVDPGGGCSGPAGDTEWDFGTACRAHDLGYDLLRYAEHKGRPLPANARRSLDARLAADMHGQCDLNPRGAATRCHLVARIYAGGLAFNSWRQRWGPPGHEPVVAWGLGSAVVVFLLLARLPRRRGPAHGPVVPPEDDRYATFLRLGSLGTVVVAQSVLTVLHWAGLDADRLWPLTWVLQATSVFYFAGGHANLVGWHAVRAHGGGYGRYLTGRITWLLRPILGFVLAWLVLPLPLELLDADKSRVETFGRLIAHPLWFLGLYLVAIAATPVMARLHRAFRHATPLVLLGVMTVVDLVRVIFGWRTGGYLNLVLGALFLQQLGFHYADGSLRNIPRRVLALVASASVPVLLVLITVGGYPRAMMALPDERVSNLSPPTICLLVLGVGQLCLVLLLRDRITAWLGGRRAWRVVAYARTAPMTLYLGYLTALAGVVGVLGLLDAPSTFALPRWPAVLVLMLVPLLLAFHRFERRFLPSPCHTRETHRTRLAATLGVGYGVLGVLGFVVTGFSGTTATLVVLDVDPLQNLIHLLLGWYLLHTAKSGACHRRRPWLLTALACVPPLLVLRPTTPMVALHVVTMAAALLAAIPNEQSARDQRQPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ03</accession>
    <name>A0A7W7SZ03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative serine protease PepD</fullName>
            <ecNumber evidence="2">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="27290" checksum="546F0ED04D54A7C5" modified="2021-06-02" version="1">MADDIPAPRGPLETRSPFWRRTGTVVTSAALAAALFGGIAGGVVGYSSAEAPVTPTATGTTVARQTSTSTGFDVSAIAAKALPSVVQINVTTTQGEGLGSGVVLNADGRILTNNHVVSGARQVTVTLADGRTVDAEVVGTDPNSDLAVVQATDAGNLTPATFADSDQVHIGDQVVAIGSPEGLQGTVTTGIVSALDRTVTVPGTGRRTVSYQAIQTDASINPGNSGGPLINAAGEVVGINSAIYSPATDGGEAGSVGIGFAIPSNQVTQILSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ53</accession>
    <name>A0A7W7SZ53_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="123"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="49908" checksum="1AECAD5AE69C355E" modified="2021-06-02" version="1">MESAAARLTEELRDLHLRAGAPSMRTLASSADMSHTSAHDALNGKRLPSWSVVANLVRALDGDVDYFRDLWNRANAPSDDLVPLYLRQEANRLRRLLGVDLMPLRVDGPYGPEVLDDFDEQLRRALFIGEPGSGNFTLLLVFARGLMKRTVDHVPFVVSLARFGDEYPPHRSIAGFVEHHVRTVNQLDVPDGWVSGLFASGRALVLFDGLSKVPDERRARIAEVVENFVLRYPDLRVALTLRPRDVGLIDEKMFAHYRMLPPETRDVDRYCDRERVPVPAPDELLITPGLVVEAVRDARRGQPWGHCATVEAYLRTVLADMITDDTVLALAALASARTEFRRAPAVAMLREVLGDYAVAQDLFDACVQYLLLGDGEGTYWFTTPAVHSYLVAVRLVAHAADVEDLVVSGPQVRRFVFELADRRWPDGAELLREALTRTDASQGKRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZD4</accession>
    <name>A0A7W7SZD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="65" mass="7484" checksum="E1870B9D8081D4FF" modified="2021-06-02" version="1">MSSDNLFIPSVHARVHAWDRDDQDGYLQDQRHAARLTVARHAHDRDDCVVLLDMLGLLPDTNPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN5</accession>
    <name>A0A7W7SZN5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="32884" checksum="9F44B8ADF47A3D27" modified="2021-06-02" version="1">MYATRFATPDDLAGLPDLLVRLQADPAHHIGYLGETLADVAGPLTPDWPARTVVATDDSGRVCALLTVETSGTRAFVHGPFVDVPVNHPAGSRIWDQTADALYALAEPLFDGIADREVFGHTRHRNLEQFAVRHGFASGRACGIHVLDGDALRDLMLREAGCPRTGPAREMRVLPTDRAVHEAVAVLHERCFPSSYLTGAKLVEDSGERTVVVAMDGDVVLGYAAGKAEPGEYYIDFLAVEPGVRGQGVGAALATELVWKLAERHGARPQAAASILVGNTSSQRMFDRLGFRLHLELIAYRSTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS4</accession>
    <name>A0A7W7SZS4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyrimidine-specific ribonucleoside hydrolase</fullName>
            <ecNumber evidence="4">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="5"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="306" mass="31983" checksum="B722ED53E482EEA8" modified="2021-06-02" version="1">MTTPLIVDTDPGIDDAFALALAAHSPEVDLIGVTTVFGNVSLEHTTRNALGLLAALGRPDVPVAAGAARPLVHPQPHVSRAHGDDGLSGLAHTLPVGTADPRDAVTLLRDLLLAAERPVTIVPIGPLTNIALLLAAHPGLKEKIDRLVVMGGGLAGGNITAAAEFNLWSDPEAARRVLVDEDVPVTLVPMDLTQRCAVTAQWLDLLSASSPTGALLTSFTPAYLATYRRFLGWDGMVLHDAVAVAEAIRPGLLTTARHPVEVDCAHGPGRGALIADRRLEAQGGIDVAVDTDLDGLRAFLLERLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T019</accession>
    <name>A0A7W7T019_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein (TIGR03085 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="204" mass="22689" checksum="4812290BBC754322" modified="2021-06-02" version="1">MGVARDERQSLVELFREVGPDAPTLCGEWRTRDLAAHLVLRERRPDAAVGVLVKPLAGHTAKVQERLAAQPWGRLVELVRTGPPAILRPLDELLNASEYFVHHEDVRRAADGWSPRPPEPVRDEALWKRVGSIARITFRKSAFGVVLRQPDGAEITARPGPRPVVLTGQVQELLLYACGRERVEIGFDGDEDAVESVRGLDRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A7</accession>
    <name>A0A7W7T0A7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="133" mass="13656" checksum="F85CB47974176229" modified="2021-06-02" version="1">MFDAGGGGGKVEFLAETVTGGAAGSALVGSQTKFSVDPAQARKLIDGLRAALDKLISLYDESGRLESTQPPGKDIYSGFAALAIRRAAGTEVGGYAWANMQAREALTKTIANIEAALAQYEATDGVAEQGMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q1</accession>
    <name>A0A7W7T0Q1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional ArsR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="33375" checksum="F8E2FF950B62280B" modified="2021-06-02" version="1">MTILRFAVSPLWETVAALRVLAEPGYHPVHRRWADWAGRKLRDLGEDPSLLTVLASRPVVPEFLIPTPGGRTISFDEEVSFLPTVAKPPRIAAAVAAEPLARPLLDNREEALGAVLDRFRAVHDAIVAPFWHRLEGVLQGDIERRGRRMVDAGAPAMLAELHQDVGYDHPDVVVHGRRVVPGDRDLVLVPSAFVWPDVYLRDSPVRLALVYPAHGFGSLWERPDVPTGHSLARLLGATRARLLLELERPGTVTELARRLGVTVGAVSQHLAVLRGAGLVVSRREGREVVSLRTSLGLALVVGEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R6</accession>
    <name>A0A7W7T0R6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma factor (Sigma-70 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001783</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="22330" checksum="70E3B3AD23DA42F7" modified="2021-06-02" version="1">MTPASPIAVLVGAAAQGDQCAWNEIVDRYTPLVLSVIYRHRLRPADAADVNQTLWLRLVEQIGRLRDPEALPGWIATTTRNECLRMLRLQQRTRPFDPLADDEPAGDEEDLAEDLLAAERRQALRDGFAELSDQCRELLARLMADPPPSYAAVSEDLDIPVGSIGPTRIRCLNKLRRTPPLMRFLDQVDEGGVLGGPVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y0</accession>
    <name>A0A7W7T0Y0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosome-associated translation inhibitor RaiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15574" checksum="F0B7656FFC96CC11" modified="2021-06-02" version="1">MPDTREGTAIVAQRLNLATGFLASERGWVSERLSKLGSRLRSFRHDEIDLEISMKDRRGAGQRVTLECWINCRPRLHLVATSSARDLPAALGEVRNELIRQVDVAETRTDPRGNRVLRLVPRLPDGEQNSIPVRDPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T149</accession>
    <name>A0A7W7T149_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="90"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="309" mass="32949" checksum="48B2153C190908A8" modified="2021-06-02" version="1">MSGYRTLPVPDGLDGMRVDAGLAKLLGLSRTVVAALTESGDVVLDGRPAGKSDRLVAGAWLEVTLPEPERPVVVQAVPVEGLVVLHEDDDVIVVDKPVGVAVHPSPGWTGPTVVGGLAAAGVRIATSGAAERQGVVHRLDVGTTGVMVVAKSESAYSALKHAFKERTVDKLYHALVQGHPDPIKGTIDAPIDRHPKHDYKFAVMADGKPSITHYEVTEAFRAASLLDVHLETGRTHQIRVHFSALRHPCVGDLTYGADPVLAKRLGVTRQWLHARALGFRHPAGGSWVEYTSDYPADLQAALDLLRAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T157</accession>
    <name>A0A7W7T157_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRSO17 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039365">
        <property type="entry name" value="IS701-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33627">
        <property type="entry name" value="PTHR33627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="28"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="426" mass="47201" checksum="6CD1F634B5E1D017" modified="2021-06-02" version="1">MVWSPAAVTPEEMAEVRPVIEEFAAGVFGGFARRDQRGTGELYLRGLLLDGKRKSMQPMAERLGVDHQQLQQFVTTSTWDHVEVRRRLAVWAAGFVDPDALAVDDTGFPKDGTSSPGVARMYCGALGKRGNCQVGVSVHAVTDWTSAAVDWRLFLPESWDDAKADDESAAAEIARKRARCSIPDQVRHREKWRLALDMIDELLGWGMPRRPVVADSAYGDSTAFRQGLTDRGLTYAVAVSASTSLHPATSAPVPPSWSGTGRPPTKTTYPDKPVTAGTLVTEAGRSAGRFVLWRHGSRTSAGNPAATMRSRFLALRVRPANRNIPRAADGSLPECWLLAEWPTGEPRPTDYWLSTLPPDIRLRDLVKLAKIRWRIEHDYRELKDGLGLDHFEGRSWLGWHRHVTLASVAQAICTRLRRTPKAPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T185</accession>
    <name>A0A7W7T185_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="146"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="481" mass="53584" checksum="EAD0E1278C2BF186" modified="2021-06-02" version="1">MTAAAEQRTTTNPLSQEETLASIGNYEFGWSDSDVAGASARRGLNEDVVRGISALKNEPEWMLDFRLKALRLFDRKPMPTWGSDLSSIDFDNIKYFVRSTEKQAASWEDLPEDIKNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHKIREDLEEQGVIFLDTDTGLKEHPELFKEYFGSVIPSGDNKFSALNSAVWSGGSFIYVPKGVHVEIPLQAYFRINTENMGQFERTLIIVDEDAYVHYVEGCTAPIYSSDSLHSAVVEIVVKKGGRCRYTTIQNWSNNVYNLVTKRAKAEAGATMEWIDGNIGSKVTMKYPAVFLMGEHAKGEVLSIAFAGEGQHQDAGAKMVHMAPYTSSTIVSKSVARGGGRTSYRGLVQVNKRAHHSKSTVKCDALLVDTISRSDTYPYVDVREDDVSMGHEATVSKVSEDQLFYLMSRGLDEDEAMAMIVRGFVEPIARELPMEYALELNRLIELQMEGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1I3</accession>
    <name>A0A7W7T1I3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14424" checksum="3833577476406BDD" modified="2021-06-02" version="1">MTGPQRPHRQRVVVTSPRTRAPRAPRPYPASREIDEGSSLGTVYMRSLIRTQRRLGMLLCVVVCGSITALPLVFAVAPHVATQRLFGLSLPWLLLGVLVFPVLVLAGWFYVRQSERNEREFAELVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1J0</accession>
    <name>A0A7W7T1J0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AlcB" evidence="5">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="21043" checksum="C2C57424A9EF559B" modified="2021-06-02" version="1">MTHLDAYRATDDLSGVPAPPVPTPDGWWLRAVDPDGPDVDLLHRWMQAPHVAAFWHQAWPRERWERELRDQLAGAHSRPCLVGRGDPVLYVEIYRAARDVVASVYPARPHDVGLHVAIGELAMTGRGLVRELLPALCEALFDADPLCTRVVLEPDVRNRRAIASFTAGGFAPVGEVLLPDKVALLMVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V6</accession>
    <name>A0A7W7T1V6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="158" mass="17150" checksum="FD32C7C6FF180AC3" modified="2021-06-02" version="1">MSGTALTVLTPYTAERVEPIVVAAMTAEGMAPDAGCPEYWRPADGLPYGYTLYPPDFENDPAEVEVVERAAGRTMLCDVGLHIFVSDVAGRPLLGRLAQRVAREAEGWVLVEFRTPPAADLIGYLEGKGRCVRVEGHVHLDASAMAAWYAHPAFHVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T257</accession>
    <name>A0A7W7T257_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="283" mass="29756" checksum="CB703977BDE6E752" modified="2021-06-02" version="1">MATPARLDHSIVITRRPEDAWALFTRLGFTLSPVSRHRVTTTPDGPPVLGCTANRCAYLDGGFVELIGIIDEAAPDPWRVLPLIAGGDGGLRGVSFGLGDSDRVLDRLRDTGLAGSGVLSLERPVGSGVLRARSVHVDRARTPEGIVHSAEHLTPELVRAVPHANGARALTGVLLFADGSEVDSIRDRYATLLDRESRKVDHGRVFDLDGGRLELVVDLDAALPGETPPSSPGFVAQEVGVADVDAARALVEGAGVPTRDVPGGFLVSARETFGAAVLFRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T282</accession>
    <name>A0A7W7T282_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_002051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009000">
        <property type="term" value="F:selenocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="31"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4964692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="45143" checksum="6F847447DA7ADD73" modified="2021-06-02" version="1">MTTTATPLDVTAIRADFPILGRTVREGKRLVYLDSGATSQRPRQVLDAERAFLETANAAVHRGAHQLAEEATDAYEVARRKIAAFVGVDEGEIVFTKNATEGVNLVAYAMGNAATAGPEAHRFRIGPGDEIVVTEMEHHANLVPWQQLAQRTGATLRWFGVTDEGRLDLSDVDGVITARTKVVAFTQQSNVLGTVNPVAPLVAAAKAVGALVVLDACQSVPHSAVDFHALDVDFAVFSGHKMLGPTGIGVLYGRRELLEALPPFLTGGSMIETVRMEGSTFAPPPARFEAGTPVTSQAVALGAAVDYLSAIGMDRIAEHEHVLTEAALRGLAEIPGVRIVGPTEAVDRGGAVSFVLEGVHAHDAGQVLDSLGVEVRVGHHCAWPLHRRLDAAATVRASFYLYNTLDEVAALLDGVREAQKFFGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2A3</accession>
    <name>A0A7W7T2A3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="297" mass="31672" checksum="2FBD23956902CA9B" modified="2021-06-02" version="1">MDVTLMTGATRGLGRVAAEHLLRTRRDRHLVVFARSGDPAAELAKATGNRNVSTIRCDLKSFDSIRAAVADLRERDLGPITGFLANAGVQEASTDTATADGLETTFAVNVLANHLLLTLLRDDFAQPCRIVVVGSDVHDPAHNSMGVVPPPVWTDARDLATPRPGGARDGRRAYATSKLGVLYLVHAHRRRLPEDVDIYTYNPGHVPNTGLLRNVPPVGRAVAQGVGVVLAMVSPRSTMPGPAGRLMAAALDGPRPGESGVYVNKGVVVPSSDESYDREREERLITVADALCGIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E4</accession>
    <name>A0A7W7T2E4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="44" mass="4541" checksum="9CE7780AC5767EB9" modified="2021-06-02" version="1">MTEPATVVYAALKALALARDRDHVAPARRPPAAAPAGLMTRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2E5</accession>
    <name>A0A7W7T2E5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="11453" checksum="AAC6917D051E00F7" modified="2021-06-02" version="1">MPKPYSREFRDDVVRVARDREPGVTVEQVAKDFGVHPMTLFKSLRQADTDEGVKPGVGGNDSAELREARKRIRLLEQENEVLRRATAYLSQANLPGKGSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2H3</accession>
    <name>A0A7W7T2H3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_002156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="296"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="486"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="747"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4964797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="845" mass="87657" checksum="8C362FBF44A52BE2" modified="2021-06-02" version="1">MFKATLKSLLSRKVRLLLSGLSVVLGVMFVSGSFVLTDTLDRSFKDLFSSAYSDVDVQVSVPSKVDGDSPDAALSGTLAPADLAKVQAVDGVDKAYGDVVGSARPIGSDGKVLTTSGAPRMGTAWRDGGREEFREGHAPRADDEVAVSAYVAKVGGYKVGQRIDVLTLEPRRSFTVSGIFGYPGGRDSLGGEMITAFTTPTAQKLLLGRKDAYSGITAEAKAGVAQDALRDRVQSALGDGVRVKTGTQLAKESADQVGEGLKFFNYILLGFAGIALFVGIFIILNTFSILVAQRTRELALLRAMGAGRGQMIGTVVLEAVVIGLVASVVGLGAGIGVGAALAQFFATFGGSSLTLAGLSVPSSAIISAFSVGLVVTVLAALLPALRASRIPPVAAMREAATPDRPLTRPTIAGAVLGALGGTGLVIGFDQGQLTLIMGGLVVSFVGVALLTPLISRPVVSVIGRLLSWSVPGLLGRRNSARNPRRTAITAAALMVGIALITGVSVVLTSATASLTKIADTQIKADLIISGENENSGGGGSFTAADMDRVAKTEGVRQSFGWYGDQVLLDGKPRFAGAMTDVPAMHTIFGMTAKEGTLGDVRAGQIGLTEEIATEQNLKVGSTARLQTTKGEERTYTVAFVYAKSTLLSGTVVVPTAVAAEFGRDRITDAFVRVADGADAGAVRKRIEPLFADNPEISVQDLSSYVKQQASQLDTVLVMIQILLALAILIAVLGVINTLALSVIERTRELGLLRAIGMRRAQVMRMITVESVVISVFGALLGLVVGTGLGFAAVRALKDQGVTDLSIPWSQLGGYLALAAVVGVVAAILPAIRAARLNVLQAISYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X4</accession>
    <name>A0A7W7T2X4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator GlxA family with amidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="21441" checksum="BE7BD840D1D0FAC2" modified="2021-06-02" version="1">MDLAFVLYPRMTALDLVGPYEVLAHQPGVTAHFVAETTEPVVTDAGLVIVPTTTFAALDRADVIVVPGSSDYEGVLAAGVVARWLREVHPKATWTTSVCTGSTLLADAGVLTGRPATTHWAVRELLGRLGAEVRSERVVRDGDVITAAGVSAGIDMALTLVGLIWGDRVAMASQLAIEYDPEPPYDAGSPESAPPEVVAAVLGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T361</accession>
    <name>A0A7W7T361_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="34" mass="3967" checksum="F5C6499CEE87FDAD" modified="2021-06-02" version="1">MKNETGRHRERPYGFVGCVAAEALRDKEFRDAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3B0</accession>
    <name>A0A7W7T3B0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arsenate reductase</fullName>
            <ecNumber evidence="7">1.20.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008794">
        <property type="term" value="F:arsenate reductase (glutaredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="PTHR45724"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4965827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="23925" checksum="C3EC46625A195080" modified="2021-06-02" version="1">MRPLSRPLVAEFLGSLLLAALVIGSGIAARRLSPDDVGLQLLENAAATAAGLYALILVFGPVSGAHLNPVVSIVDAAFGGLPWRHVALYVPVQIAGCVTGAIVANVLFDAAPVSVATTDRATWPHAASEVVATLGLLLVIFSLTRTGRATRVPAAVGAYIGAAYWFTSSTAFANPAVTIGRAFSDSFAGIAPASVPAYVAAQLVAAAAAILLLRVLYPVAPDPWPVGRPVKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E6</accession>
    <name>A0A7W7T3E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="346" mass="37988" checksum="4A7494F035125690" modified="2021-06-02" version="1">MDAPRTRACAYCGLPVTARKPTGRPPRYCPAEQRDCQARARAERITARAAGMTGGPGALRETVLELAGQLDEVWEPLQDLVGVVQGSRDLLGAVRDELIARAEQAERAAEEAHTARQQAEDRARVAEAARDEALHQAQEARTQRTEALRARDAADRARQDSLLAQERLRAERDAAREQADKAKTDASAAVAQAEAVADARVREAVESTARAREAAAVLRGELATARERLDERATRVRDLEAEVDRVRDRLAVDLARITAEITADADGRVERAHAENRAQDARSREDLHRLGVQTERADRFERAHARLLDRVAGVLREATAPAEEHDAGRERKALDTLAALLSVETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3G0</accession>
    <name>A0A7W7T3G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="45362" checksum="C4710BE3BD5E44F5" modified="2021-06-02" version="1">MLVGTGQRDAVRRVTGLARSTPGRLTLVALLLIAVSLTAGALSVRSVERRSADLETLAERSEPLAYAAQEVYRAMADADATAASAFLSGGVESPALRARYQDDIAKAAVALSFATTETVRSPDLSAALTTLAGQLPVYTGLVETARTHNRQGNPVGAAYLREASALMRDRLLPAAEAVYRAESASVVHGLRSAGLFPYVELVLGLAALLVLVFAQRFLTRRTNRVFNVGLVAATLATTVSLLWVVTASVVVMIRVTDAEDHGAYRVDTLAQARIAMLTARGDEMLTLVSRGSGAGYEKRFTQYDTRLEGLLDNSDSWPTVRPELLDQHERWRTAHKAVRDADDRGEYTQAVAVALSDGPDGAARAFDALDASLVEGLHRTRTAENDMIASARGALTGAAPVAALMAVLAAVMSAAGLWQRLKEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R8</accession>
    <name>A0A7W7T3R8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="277"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="313"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="535" mass="57620" checksum="A434213FA4B11DF5" modified="2021-06-02" version="1">MAPQDRLTLLRVEGLSVAYGDHRVVSDVGFTLARGESLALIGESGSGKSTIARAVLRLLPRGVGRAHGVVEFEGRDVLSLPERRFRPLRGRRIGFVPQDPANALNPVRTVGSQALEAAALTGSADRRDLVLDTFAQVGLDDPRRVFDSYPHQLSGGMLQRVLIGLTVLPRPALIVADEPTSALDVTIQKRILDLLSRLRAELDIGLLLITHDLAIAAERADTLVVLKDGVVQESGRTETVFASPAADYTRRLHADVPALNPDRYRDLRTGRVGTPRIEVSGVTKTFTVEGRTSTAVDDVSFVVDSGTTHALVGESGSGKTTTIRLLLGLEEPDRGGITVAGEEVTGRSHASLRSLRRHLQLVYQNPFTSLDPTWTVRRLVAEPLDRFGVGTRAERADRVRAALASVGLAEGLLSRTPTALSGGQRQRVALARSLVLRPDVIVLDEPTSALDVSVQAGIVEVLLTLQAELGLTYVFVSHDLSLVRQLAHTVSVMHRGRIVEGGPVDVVFDNPVEPYTRALVSSIPSGRPGVVEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Y8</accession>
    <name>A0A7W7T3Y8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="396" mass="43478" checksum="38F81318C6447D9F" modified="2021-06-02" version="1">MDQLVHGSGGDVAPTVGQVGLIAAWPDPVVRNLRITYCYHELSRSVAAWTGGSSNWCTYAVWASKQIGQTIRQEDLTRAVERLMAASPETAALVAAVREGLRRAVPGHRLEDTEKLVRDVVLAVARLDAASAAGAAGNLKVFAEIAHEFARFLAEFADDTALDEDRLAAFVAGLRPGEPPDGQDHLCRAFGHYLRARFDPEHRAELLFLANIEVGVHEQTRLQPEITAAMEAPFVDPAELERRLLDLVLPHNPALRFLRLALVTVLRRRDHVRAPGKRLAENVRALARRAVTAHLMTLTLPDGTYLELGKDLTLPFPPSLATLTDPALLELLARLDPTPDSPLDTAARDWSDLADRLHYIVDMFRCTAERADLLDCPFTADQVDAFTAGRLPGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z2</accession>
    <name>A0A7W7T3Z2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor (Sigma-E family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_003472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4966113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="20387" checksum="A9984D6B7018C2FF" modified="2021-06-02" version="1">MRGSRSADEEQFRAFAARSSGPLTRLAYLLCGDGHLADDLVQTCLIRLYPVWPRLRDPDTADAYARKVLLRCWLNERRRPWRRSESGDGVVPDLPDDRADPAEAVGPEHDKQVLRRALAAIPPRQRAAVVLRYWAQYSVAETAAIMRCSEGTVKSQTARGLAALRVAVTSSDPIKEKAWTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T468</accession>
    <name>A0A7W7T468_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="107" mass="11339" checksum="70F80F040C89C2B4" modified="2021-06-02" version="1">MSGGFDVSPQELRDFTSKLDGHRATAGEIAGLVAKADVTDKSWGVVGLLVKSNYTGMLGDLKDLFTAMQDGLRSGSDKFTGAAQGYDDQEAAVKELLNGLQVELDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4G5</accession>
    <name>A0A7W7T4G5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="29720" checksum="3B0CBFB8018EDB86" modified="2021-06-02" version="1">MDSRSLHTAARRHLAACHDDVVRHGESMGVRSPHGRYRVEHERAFPLDVLAAEIPHEVERLDPDDLPEPRALAAALTAAAFRAPTHGTDRVAVAAEEAERLLFREAVRDWSTSDEPVAPLPYRRVLSVEEFSLWTDRLVSRWGLRDQVWYPIVDDPPADVLVLRVEAMWDGPGEELVLRALRGLGSGRVVELDEGNRSDGRVIDLDLFVPWYEGVEKVWCDETLDWICFASHESTVAFGGTLADALIASWPDIDRWRCTGWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4J2</accession>
    <name>A0A7W7T4J2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031294871" evidence="1">
        <location>
            <begin position="31"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="83"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="526" mass="56385" checksum="E1E1D04309EED21A" modified="2021-06-02" version="1">MQSRRFTGIAAFVAAGLVLTACATPATKSADEAGPPVRGGNLTVRLAQDPGSLDTVRNTNAGTTYVGHEVFEQLVTIDAGYQPQPVLAESYKKSDDGLGFTFTLRKGIVFSDGTPLRAADAAASLRYWVENGSYAGSLKPVLKEISAPDEQTVQVDLTAPFNLVALVATSHGTGIRKEADIKAAGPTGIGRDNAIGTGPYKVKSWTPGQEIVLERNDKYQAPPGKSSGYAGAKNAYLDTITYKIVADSDAVLNGLQTGLFDVAEPSHDQYDQVKRDSTLKIGVEGAANIQYVALNHNAGSIFSKPEAREAMNLIVDKKAVMASQGVPDLVSASNGAFAAQSNKAMYSDAAKSQWDQSDPQRAKELFAAAGLKPDQTVRMITTDEFPQFKDALVIIQDALKKIGVNATIDSYDFATLMGRKNTQPDSWDVLALMDDANPPVPSYSDNVQGLDNMGYPRDKLAPLLTKYNAARTPEEQKAAIDDIQKFTAANLPTITLYSAKSYVAFSAKVRGYDGWGMEFADVWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K4</accession>
    <name>A0A7W7T4K4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="121" mass="12845" checksum="A5129F671603A0F9" modified="2021-06-02" version="1">MDESRPLTATEKAVLDLLLSKEFPGAAELRAQVAVAAVTGRCGCGCPSVDLSVPDDVPRSPYRGRLAPTEARTEPDADGLPLEVILFLDDGALSYLELIHYGEPPEDWPAAASLSVVRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M5</accession>
    <name>A0A7W7T4M5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29381" checksum="61AD5C8813918CEB" modified="2021-06-02" version="1">MTGRRNRKLLVVGGLLGLITLLVLVLPLLLPDPDAPDPVNRLLSPSFEHPMGTDKYGRDLFARWASAGRVSIGMTLLITVCAATLGTFIGLVAGYFTRAGTVIMRVVDAWMAFPSIILAIVFAVVVGPGMLSELLAVTIIFTPYTARVIRSRVLGLTTRAYVKAARVAGMGPWKTLAVHVLPNTLPLAVVQCVLLSAGAMLIDGSLSFLGLGISPPTATWGNMVSDGRTYLHDHPTMVLFPGLTIALFVFLLNLAGSGLRTLVDPRARQLADRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4P7</accession>
    <name>A0A7W7T4P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative house-cleaning noncanonical NTP pyrophosphatase (MazG superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4789" checksum="6F6D5EFAAB275D52" modified="2021-06-02" version="1">MLEVVHAIAARLGLPFEHIEELRVRKAAERGGFTDGVVWSGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4R6</accession>
    <name>A0A7W7T4R6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-uridine nucleoside N-ribohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="29557" checksum="270582B8091936A1" modified="2021-06-02" version="1">MRGPLIVDTDVGGDPDDAVALVVAAAEPDLALVTTVDELGGRRARFARHLLDLLGRADVPVVAGADLGNTRMDCVPEPEPVDDRPTDVLGAVAAVCASTTGPVRWTGLGPATNLARILDTDLADRLVVTQMGGALRYRDPTRAEHNFRVDPEAAVVLLDRATRPTLVLSDTTFTPAIGIARDSPTHRRLTAPSAPAWAGLLADHLDRWFTRFHPVTLQHDALTLSLVLGLPFVETAPHRIAIDGIGRTTTAPDGHKVLLSVGADHRAFMAWLADRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T539</accession>
    <name>A0A7W7T539_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10784" checksum="D9107577703494B2" modified="2021-06-02" version="1">MASGGVLTAVAGSVAVLVLVVVWRRRSVRRSRAGGVRVFSLAGRTVVGASVIVAGQWLALTHPDTTTVVRVAALGLPALVASWSLVRALTVTVLDDRRRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J3</accession>
    <name>A0A7W7T5J3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030528646" description="IPT/TIG domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="3">
        <location>
            <begin position="246"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="338" mass="35022" checksum="81F6D0AD76B954A6" modified="2021-06-02" version="1">MRSHKVLIAAAIALVAVSGILAIWPPRQPGTRTGDPRLPAAAGTAVVGTRPPPPARPAPTTTTTPPPTTALRSTTTRPTPPPRALQPTTTTEPPAAPRRQAPPPDEGFPWLPPGPADPGDPAPYRWYAAYAQGKCDAEPPKGPLWEAVDALCDAAVDGETNEWAHAKSAAASAPAPSNCLETAATALLRRALAWHEKHPGDTKPVIRLSALDDTPACALAVLDLTTAPDNLTCAEALAPQAAAIPAGPVTGGTRLLLTTTGTDRNSTKVTVGGLQAKIDCLSPTRVIIRTPPSPRSGRVTITVTTSTATANAPAQFEYLRSRSDTTTTPMPRYAPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R7</accession>
    <name>A0A7W7T5R7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_004415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="74"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4967056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="34780" checksum="8DA86541C5D3F54A" modified="2021-06-02" version="1">MDEPRVLAPAVPVADRVFRAVVRSCGVLVLLIMGGIGLFLAYQAIPTLDVLGWSFFTENRWRPESNQLGILSIALGTLQVALVAILIAVPVALGTALYISEYAPLKVRRTLVALLDLMAAVPSVIYGLWGFFFLQGEIIYLSRWLSRNLSFLPFFKVETDTTAAVWEKSQYTSSIFICGVVVSMMVIPITASVMREVFSSAPVGEREAALALGSTRWGVVRSVVLPFGRGGIIGGTMLGLGRALGETIAVALIISPAFDVKFRPLEKGGNTISQLIALRFGESSPFQLSALLAAGLVLFLFTLLINVLASTVVARSRSGAATEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T5</accession>
    <name>A0A7W7T5T5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="700"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="789"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="901" mass="98585" checksum="93A888688CAF45FC" modified="2021-06-02" version="1">MPRGERPLDVGDSPLLRFAADLRSLRDRSGGQSYRQLGARAHYSATTLSDAAGGRRLPTLAVTLAYVRACEGDVDEWEDRWHQVAAEVLPTPEPVPGEGNPPYAGLAAFQTEDADWFFGRDRVLDDLDKRMAGHRFVALFGASGAGKSSLLRAGLVPRFDGRAIVTTPSSSGVRVSELDLAADLVIVDQFEEVFTLCPDVDQRTAYIDALLDAPCRVVLGVRADFYGHFAQHPRLVAEVTDGQLLLGPMGPEELRQAIMQPAVKASCTVETALVSRLVADATGQSGVLPLLSHALLETWRRRRGTTLTLAGYEAAGGVQHAIAQTAERTYTSLEKQQRVLARQVFLRLTALGDGTEDTKRRLPRAELDNDVDVDVVLDRLAHARLLTLDRDGVEISHEALIRSWPRLRGWLAEDRDGLRTMRQLTEAAATWDSLGRDPDALYRGTRLDTAVEWTRRDGVRTSSRERQFLAESEQARDRERRLAHRHTRRLRQLVALLLVLLLCAGTAVVLAIRAQKTAAEERNRAIAWSLNSDAQGVRASDPQLANQLVLVAHRLSPNDDLRESVLSANAATTPDMVTRSAFPSDSTLRPDGRSLPDVRVPEKADGRYHRLGDMTQPPNTVTSMAVNGVQQAFATTLGEGIGRIWDQTDVLKPTVTYRFPMPLAQIVYSPSGRIVATATADGAVTLWDVVDPTQPMQHGTTAKERPLSGLTFSADSRMLITWDDSGRIRFWDVTRLEEPQRKGGFLAGRNVTAVTMSEDGRRLAIGAADGTVEVRDLTTLSMPRRIAVVDGHQSGVRALAFRGGANDELVSVGSDDTVRQWAVTGQSLTSKARVSGRTSGVITVSFAGTTAVTSNADGTTRPWEFDFGKAVAAICAEVDAPITREQWDRYVKALEFRPPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U7</accession>
    <name>A0A7W7T5U7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="27407" checksum="A86C24F927962D79" modified="2021-06-02" version="1">MSEGQVRVERDVAGLAILTFDAPPLNLYTADLHELLDGALGDLEDRPARALLVRAEGRVVSGGVDVNLFAVQHTVTGAKLLFDRMIDLPDRVAALPFPTVFAAHGVCLTWAFELALGCDLILAARGATFGLVEKVIGLTPAMGGTQRLAARAGVGRAKEVVMTGDRFDAATLERWGVVNRVLPDEGFDDAVVAFAQDLAAGPTLAHAATKRVLAHYESGGVAEADEHVPAIAAGLFDTEDLRGAVRSFLADGPGRATFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5X1</accession>
    <name>A0A7W7T5X1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28625" checksum="8CBA34D552989FBA" modified="2021-06-02" version="1">MASIEVQGAYVDFPIFDAKSRSLKKQVLGKVGGKIGTDARVPIVEALRDITLSLKEGDRVALVGHNGAGKSTLLRLLSGIYEPTRGSARIVGRVSPVFDLGIGLDPEVSGYENVMIRGLFLGMSRRQMRQRIDDIAEFTELGDYLELPLRTYSAGMRVRLAIGVVTTIDPEILILDEGLGAVDASFIAKARRRLVDLARRSGLLVFASHVDDLLRELCTTGIWMDEGRMIMHGALDEVLAAYKGRSRSDDDRKPVEATVVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5X5</accession>
    <name>A0A7W7T5X5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="120"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="540"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="627" mass="65813" checksum="773F7179336EE78E" modified="2021-06-02" version="1">MIGRLLVANRGEIARRIIRTCRDLGVSPVAVCSDPDADAPHVREADAAVLLPGAAPADTYLRADLLVSAALASGADAVHPGYGFLAEHAGFARAVREAGLTWVGPDPDTIAALGSKTAAKRLMRDAGVPVLPDLDLASVTEFPVLVKADAGGGGRGLRIVRSAADLAAAVASAGREAASAFGDGTVFCEPLLENARHVEVQILADAFGTVWALGERECSIQRRHQKIVEETPSPAVSPESRSWLCAAAVSAARAVGYVGVGTVEFLLADDFRFLEVNTRLQVEHPVTELVYGLDLVAWQLAVAEGARLPEEPPAPRGHAVEARLCAEDPAHDWRPSSGTLHRFRIPGDVRVDSGVEDGSVVGVHYDPLLAKVVAWGPDRASAVRKLATALARADIHGLVTNRDLLVRTLRHPEFGRGATHTGFLAEHDLVTPPEVDPRPYALAAALAAAERGRVGRHAPTPPAWRNLPSQPQKAVFDRDGEIVAVEYGFGRTGVTTNVEVNVVCTAPDEVVLERDGVRTRFPVAFHGDRVEVGSVTLRVVPRFPLPTPDLAEGAATAPLPGTVVRVAVAPGQRVAAGAELLVLEAMKLEHRVLAGAAGTVVEVRVAAGHQVGAGDVLVVLAAGGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5Z9</accession>
    <name>A0A7W7T5Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="20642" checksum="D29B95B66051785F" modified="2021-06-02" version="1">MVDPLALSRAEVEFLLRVRPPALDSLRTELHLAPADADAGGRSLTARGLCRFAGGRVVFAAAVAAVADGLSRADRLIRLLGWDGDRPVVAHLLTGPGVHIGLVSARPDRFTAHRPGRAESLRDQVARFLDRHLTGKRRSTLLVRTAGATGSVDLAVAVDDDGTWSMSDTLASPTRTSPSSRDLAVARIAELVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T600</accession>
    <name>A0A7W7T600_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative flippase GtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_004524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GtrA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="8">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="9">
        <location>
            <begin position="277"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="404" mass="43174" checksum="6DEE657960B48F9E" modified="2021-06-02" version="1">MTTATLTTTTVLDVVVPVYNEERDLAPCVRKLHADLARTFPYPFRITIADNASTDGTAAVAEALAGELPHVAAVHLAEKGRGRALKAVWSASDAAVLAYMDVDLSTDLAALGPLVAPLISGHSDVAIGSRLARGARVVRGPKREFLSRCYNLILRGALAARFTDAQCGFKAIRADVARRLLPHVEDTGWFFDTELLVLAERAGARIHEVPVDWIDDPDSRVDIVSTAVADLKGVARVARGLMTGRIPIGDLRAQLGRRPLEPTTPGVPPGLFKQLVRFGAVGVASTLAYLLLFVLLRGGIGAQGANLVALLLTAIANTAANRRFTFGVRGRDGAGRHQFEGLLVFALGLALTSGSLFLLHRFAQPGGTAELVTVIGANLMATVLRFLLLRNWVFRTRPSTVENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Q0</accession>
    <name>A0A7W7T6Q0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="225" mass="24201" checksum="2F274660C3F2A69A" modified="2021-06-02" version="1">MRILIVEDEVPLADAIARGLRREGMAVDVAYDGESGHEKSTVTRYDVVVLDRDLPGMSGDELCKEILGSGALTRVMMLTASAGLDDRVAGLSLGADDYLAKPFAFPELVARVRALARRATPATPPLLTARDVELDPARRTVRRAGQPVELTRKEFGVLEVLLAAKGSVVSSEELLERVWDENADPFTTTVRVTVMTLRKKLGEPGIIDTVVGSGYRVPTAGSAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Z4</accession>
    <name>A0A7W7T6Z4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="214"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="400" mass="43451" checksum="0F5E62395650D30A" modified="2021-06-02" version="1">MSGSHRVVVESGTTLPDGDWPWEQGDLKEAWPYLGPTWLRATEKALPEAGPWHTVARRGRGEIAYLPGFVFDGPPAVDFDPRTYLGWQAASGQEVCCGTSVCSDTVAEIDALGLAPFFPVLVLGSPLGYRTEAAFTFWTRSLFPTLLGNAVESALAQGVRSVIAPWIPDRLGNEHLAGSFGAVGGSTTFWGYEDFLRLDATDYESHLEALPLKRRRRITEDFDRVSAARVDLSRVTGEEIRPFVGRIAELTCLNREKNGAGEEPSHIETILTALLDAGADVRCHLARKDGAVVGVCVAIRKGDRLFLKWAGFDYAVLGDRSGVYFGLVLDAPVREAYDEGLRFVEYGAGAHQAKALRGCAPRAVTTGLVVADTGLRERVAGRLAEFGRTRHEVFGGGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T712</accession>
    <name>A0A7W7T712_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosome-associated toxin RatA of RatAB toxin-antitoxin module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="16223" checksum="AA40A9A64FF7EDA2" modified="2021-06-02" version="1">MADESTQSIVIDAAADRIVDVIADFATYPEWANGVKATEVLETRADGRAAQVRFNIDQGPIKDEYVLAYDEWSPGLISWHLVKGQMQKFQEGTYRLTPKGGGTEVTYTLSVQLVVPMIGLFRRKAEKMIMDTALKELKRRVEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T770</accession>
    <name>A0A7W7T770_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="88" mass="9935" checksum="0C2127D11BB57A90" modified="2021-06-02" version="1">MTFDRKEYEEFVAAMIEDERPRMFAVLREYGECEDAEVVAWGFAWTGHATALLPGGNVLRSGSADRAARVLERGHHGPTRLVWMDHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7B9</accession>
    <name>A0A7W7T7B9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031268341" evidence="6">
        <location>
            <begin position="33"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="7">
        <location>
            <begin position="205"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="496" mass="51183" checksum="36CE8E4CDDC88841" modified="2021-06-02" version="1">MAGKTRRALAALAAGAVAVVGLTLVVQGSASAANLVYNSGFEAGNLTGWTCTGGTSAQTATKRTGSYALQGTPAGHDTAKCSQSVSVKPNTNVKVTAWVQGSYVYLNSGGKSTWTSSASSFTQLSLDVTAPASGVVEVSVNGWYGQPSFYVDDVVVDGQPNGTTTTNPTTTTSGPSTSTSTSTTTTTTTTTTTTNPNPGTGLPKHVLTGYWHNFDNNSRVLKLADVPTTYDIVAVSFADATSTPGAVAFNLDPVLSSKLGGYTDAQFKADVKTLQGRGQKVILSVGGEKGTISVGSSTAATNFANSVKTLIQNYGFDGVDIDLENGVNSTYMAQALRSIYAAGGQIITMAPQTIDMQSTGAEYFKLALAVKDILTVVNMQYYNSGAMLGCDGKVYSQGSIDFITALACIQLQNGLRPDQVGIGVPASPSGAGGGYVSPTVVNNALNCLAKGTNCGSFKPTQTWPSIRGAMTWSINWDAVSNWGFANTVAPHLDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7E6</accession>
    <name>A0A7W7T7E6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Icc-related predicted phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="263" mass="28960" checksum="B85072CF6F84D531" modified="2021-06-02" version="1">MRVHVVSDVHGNAEALARAGDGADALVVLGDLLDFVDYYDHGNGILGRIFGAEKVRVFAEMRTGRMPVEAALYLRSLWAQVDDAAEVVREAVLEQYERLFAAMPAPTYATPGNVDSPELWPRFAGRGVHVLDGEVAEIGGLRFGFVGGALLPPAFAPRRRGGPWHAYLRTEEDFGAAAVGLTDVDVLCTHIPPAVADLTYDVVARRPEFGSHALLKVIERDRPRWSVFGHVHQPLSRRVRIGRTECVNVGHFQRTGTPHVLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7F1</accession>
    <name>A0A7W7T7F1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13364" checksum="CF55792E915297C1" modified="2021-06-02" version="1">MSTPPRKDPMKSFRGIMAGTLILEAIVVALALPIVAKLGDGIGTGTGYFVLGLIVVLIGTCGLLKRPWAVGVVAVVHVAMIASWWLLTALGGIGVVFTLVWVYLLWLRRDVARRMAEGRLPGQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7F3</accession>
    <name>A0A7W7T7F3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="381"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="610" mass="65703" checksum="B7B955DE89947877" modified="2021-06-02" version="1">MGAQRPDSADATLTVPSLAELRRTTRSVRSAEHGPAVRRALRPRGLEGRGPLTLQLLVADREARLLWHSPDRVLMVCPPRSARTRRDVVTACLHVVNVLWPLVSWFTAPLAIGLTAVALALVRAPDVLVLLLVVVTMLWATGVMVLMAIREGADLVRMVSPRPVHRRRRMDDGLRVDHWSIALCHADPDTVGALLRDATALVDHLGDRYETVPDRLLLCRPDAVTTTAALEAVRRSATVRRVSGREVLVVHDVGRPVPRPAADPGPNGILVLLAAACSLLPMIAGMVAAAEREACATACTGGPVGYGDAVFWLLRHFVVLGIPGVAPSTGQSKALGLAMALLGLVIAARVVRVVRTRQREDDEEREGFVDDVARPYSTALVLVANDIERAAVLTAVATGEVTRLRSEHHTALDLGVVGRTRVVLGWTEQGIDTQGAATLTTDALIRWLAPDYVLIVGVGYGLREHAQEPGDLVVSSRVRSMNWRKEAPGRTIVRGELAVAPQRLLDRCRDAARDWSGPRPDFGLTLSLGVLVDSAEFRAGLLDLEPDAVCGDMELAGVQAACSKHKVDWIGIKGISDYGMGKTDGHQPLAARNAAEFLAHLVRTGNLDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P0</accession>
    <name>A0A7W7T7P0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator GlxA family with amidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="218"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="34940" checksum="B656B826B217F05F" modified="2021-06-02" version="1">MHEVAVIALDHVVAFDLGTVPQILNAARVSDEERLYRVRVCTRGGRPVRSSSGITVTPDHDLGLVGHADTVVVAGMHANAPLLEDGVLADDVREALVSAHARGARVMSICTGAFALAAAGLLDGLRATTHWMYTDAFRRLFPRVDLDPDVLFVDEGRVLTSAGVGAGVDLCLHLVRRDHGSEAANRAARRCVVPPWRPGGQSQFIERPVPHETDTSTAVAREWALAHLDEPVDLRELASRARMSVRTFTRRFREETGVSPGQWLARQRVERARHLLETTDLAVDQVARHAGFGTGAALRQRMTASLGVSPSTYRTTFRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P7</accession>
    <name>A0A7W7T7P7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031104293" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="176" mass="17743" checksum="58B14274BE5A05D0" modified="2021-06-02" version="1">MKFAGLAVGGCLVLILAGCANRPENPADDGRTTVSAPAEAGAPDTTFAAFGGQRVWANGLSVTVSQPRSLEPSDASFPTTPRLAVFTVTLANGTDAAYRTSQLAVHAVVNGVPVAEVRDTLQGLNGIASAVAEVAPGGDATLTLAYAVPEDAVRLQLVVEPNGTGKEPSATFEGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7P9</accession>
    <name>A0A7W7T7P9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein ZapE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="PTHR12169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35896" checksum="2DF6F06EC8A8878D" modified="2021-06-02" version="1">MSAPRLSDRTPHVEADEMIDAMVPPPRFDRVRFDTYVPNPDEPSQAAAVRAGEKFAGAVGTAGAGGWFGSLFRRSVEHKPGLYLDGGFGVGKTHLLASLWHAVPGPKAYGTFVEVTNLVGALGFGETVRRLSGHRLLAIDEFELDDPGDTMLVTRLIKELTTAGVSVAATSNTLPDKLGEGRFAAADFLREIQSMSARFDVVRVDGPDYRHRGLPDAPDPMSDQDLAAKAESTPGSTLDDFDDLCAHLAHVHPSRYGRLLDGVTAVHLRGVRPAPDQAVALRLVALGDRLYDRDIPVAVSGAALSGLFTDEMLRGGYRKKYLRAVSRLVALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W0</accession>
    <name>A0A7W7T7W0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molecular chaperone GrpE (Heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="161" mass="17837" checksum="884423C1796A5E95" modified="2021-06-02" version="1">MDDIIGKALGEIKDELAGLHEQNRFLNGVMDRLHAENERLRNAEAQRVLQPALRELVKLADDWRARGTALADKDPAQARLCEEVVEDVTLLLDRQGVEEFTAAEGTAFDRHEQRAVGTTPTDDAALDGLVAAVRKPGYRVDARVVRFAEVLVRKFTPPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T827</accession>
    <name>A0A7W7T827_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="27230" checksum="BD832856AA639035" modified="2021-06-02" version="1">MPRTKHELPAAITLPTTLVLGAPKGGQLRRFLESLVAELGPGVLLPSERVLAQRYGVARMTVRQELDRLAAEGVVVRRPRHGTFVAEPARAAVDLVASFTDHARGLGLTPGARVLCARVEPADEPVAGRLGLAPGSPVLLLVRLRTADDVPMALERTCLSVERFPGIEAVDWTDRSLYAELTRRWDVRVAGSDTRISAVLPAPDEAATLGIGCTQPCFVIEGVPRDTTGFAVESGRSVYRADRYEVVTRVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T843</accession>
    <name>A0A7W7T843_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="29635" checksum="F51F6931E7B7CE7F" modified="2021-06-02" version="1">MAETPVGITINGNPVHDGPRVTPEEQPLKPPNLQNTSTNPQEFPGISNHLPTLTPPGPRGLEQIGHTTRRHLITDPGRKTITGRAHTAERPSSGPKVPRARVFTSRTCTNPCPEVPTWTKMTERRNSIVSLCHHRGAVVTVEGSSAVYEADGGGGKVDFVAETVTGGAGGSSLVGSQTKFSVDPTQAHKLIDGLRKALDKLTQLDAHREQLETTNAPGKDIYSGFAAMAIRKAAGTDVGGYAWANAQARAALTKTIENIEAALKQYQGTEENAEQGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8A1</accession>
    <name>A0A7W7T8A1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d ubiquinol oxidase subunit I</fullName>
            <ecNumber evidence="13">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">F4559_005768</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="13"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4968409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="42521" checksum="F8D4C35EA42A1CC3" modified="2021-06-02" version="1">MDALGLARLQFAVTTSFHFLFVLLTLGLVTLVAVTQTRATVTKNPVQWRMTRFWGRLYVVNYALGIATGIVMEFQFGLNWSGLAEVAGDVFGAPLATETLVAFFLESTFLGLWIFGWDRLNRWAHLALIWLTALTAYASVLWIMVANGFLQHPVGHVDDGGVLRLVDFGALLTNPTFRVAFAHVFSAALTVGGVFVTGVSAYHLIKRTKENEFFRSSLRLGVVTTALATPFLIGAGFGQFPVIGEFQPDKSAAAGTLGGIGLGLMILTGFTLFLASWLGLPLLLRDWVIRLRFPLYLMVLSIPLPFLAAIGGWLYRELGRQPWLVYGVLRTEDAMSPVSESGMLTSFIAFTALFAVLAVADWVLIARLARRGPEPVDAPATPVSPLVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C0</accession>
    <name>A0A7W7T8C0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response OmpR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="231" mass="25633" checksum="3F31641A89A45C2A" modified="2021-06-02" version="1">MSAVLVVEDEPDIAMVLRVLLTRAGHEVLLAGDGKSGLRLVHETRPELVLLDIGLPAMDGWTVLERIRDVSDVPVMLLTAHGQETDKVRGLRGGADDYMTKPFSNGELLARIEALLRRAGQQQAPAEPADQVYDDGTVRVDHMSRRVYLEGAEVTLNATDYGLLTMFTRHRGSVLSAGQLLATVWKDHSGLGTERVKFAILRLRRRLGWTADTSPIKAIPKMGYRYDPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8I6</accession>
    <name>A0A7W7T8I6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="10676" checksum="601AC05DD22CC323" modified="2021-06-02" version="1">MTTVEIRKPETRLARVWRGVGGVVTAGVVLLALAVGAVQVYAGVHDLPGPGLSSVLCHVLAAVVAVVAQVLADRRTGRVVPWCTVVVLVSAALVLWFFWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K5</accession>
    <name>A0A7W7T8K5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase YrrM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="21859" checksum="86A07E3340470FBD" modified="2021-06-02" version="1">MDVALREYVERYPPEDAVIAAARARGVELGCVPIGSGGGAALRFLAAATRARTVVEVGTGAGVGALYLLGGMTPDGILTSIDVSAEYQRAARRAFADAGVAVSRTRLITGAALDVLPRLTDGGYDLVFVDAAKTEYPRYLAEAVRLLRPGGVVAFDNVLWQGRVLDRTVRDPATTALRDVTRAVREDDRLVPVILPLGDGLLVAART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B4</accession>
    <name>A0A7W7T9B4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16568" checksum="D915C5E68D07D62C" modified="2021-06-02" version="1">MAELKARLQADLTTAIKARETVRAGALRMTLAAIQTEQVAGKTARELSDDEVLKVLAREVKKRREAAEAFAGAGRTEQAELERAESAVLEDYLPTPLSDDELATLVDAVIADLTTQLGEKPTLRQMGQVIKEANAKAAGRAEGGRIATTVKAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9R7</accession>
    <name>A0A7W7T9R7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uma2 family endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19558" checksum="D4BFD3C76A8FAC8B" modified="2021-06-02" version="1">MFTVEEYVGLGEFEFGYSELQEGRLHISPSPSKRHMIGSGELFVQLRSQVPADLIAIQDLDVDLGLASEAEPGFSRRPDLVVARRSALKREGMLRASDVVVIVEIVSPGSKRTDRVVKRSEYSDVGIPHYWIVDLDEPVSLIACRLVDGGYVDDGEVVDEFRADAPFPVRVDLNALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9U7</accession>
    <name>A0A7W7T9U7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="159" mass="17265" checksum="C4E025132782A651" modified="2021-06-02" version="1">MIRRVGGPSGRGAALEDEWTRYCLEIAGRRAFGWVLVGVVAFVVHLVVVSQGWGGGTVGWGLLVFAVVVLGLGMVRRPAPSVMAEGAPWKFVRVHWRGGRLVVHGDGKDVVLDVTAGPLARGRINRHRRAWVLEPGRRGETVVTFRGVPRLFAARVLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTE6</accession>
    <name>A0A7W7WTE6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="119" mass="12753" checksum="A657B3C411CEECC3" modified="2021-06-02" version="1">MPSEDHGRGVPAMAHTLNVDPTAIPSLKSAFAGALARLDQQIELAVTEVRVRPWAGDPVSSEAAEKFNERSLESGDSGLAALLGYQRQLKSAMDALILVERQYQTIESDNTGLMQQGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN3</accession>
    <name>A0A7W7WTN3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-dependent oxidoreductase (Nitrilotriacetate monooxygenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="46892" checksum="49E00F804210329C" modified="2021-06-02" version="1">MPKQIHLAAHFPGVNNTTVWSHPQAGSHIEFSSFEHFARTAERAKFDFFFLAEGLRLREQGGEIYDLDVVGRPDTFTVLAALAAVTDRLGLAGTINSTFNEPFDVARQFITLDHLSGGRAAWNVVTSWDAFTGENFRRGGFLPADQRYARAKKFLDAAGVLFDSWRDNGKFAIKDDQFDISGTFDLPRSPQERPVILQAGDSEEGREFAAAKADAIFSRHSTLVEGKAFYADVKGRLANYGRTFDQLKILPAATFVLGDNDSDAQEKAHEVRRQQVSGQTAIKLLEQLWNRDLSSYDPDGPLPESDPLISDEHIARGRASVRMHRDPLAEAAKLRALAEAKNLSIREVIIETRADQTFIGSAASVAKQIDDLVQADAADGFILVPHVTPGGFDEFADTVVPILQDKGVFRTEYTGTTLRDHLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU05</accession>
    <name>A0A7W7WU05_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="14170" checksum="6D2C1A2A9EDC4D9B" modified="2021-06-02" version="1">MPRLMSVAMTEDAVRSRIKTVTRRKGWVDLQPGTRLTLCRKIMGRKPGEPLVRIVDVEVVSVRRERLDTITADDVAREGCPGMTPDEFVDRFFVRAQRIDPAAEITRIEWRYLPDTTEETVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU63</accession>
    <name>A0A7W7WU63_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine/putrescine transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40555" checksum="CE6FD6631B8E7B85" modified="2021-06-02" version="1">MTEPVRIARLWDGGVTRRNLFRSTAFFALAAAGACGVGQAPSATTTADAPAKATNARDEKKLNFYNWTDYIAPDTLSGFTAVTGIEVTYDNFSTNDEMEAKIASGAAGYDLVVPSDNFLRRFLRAGLLQPLDHDLIPNLKNLGRRFTEADYDPGNRYSVPWAWGTTGLAYSKAALGTDVTGFSAYDLAAAQGRSTILDEARDGLAVGLLKAGHDPNTTSAAEIDEAVRVLLDLKKKLGQITSDVIEPLTGGQVPLAQAYSGDAFQARATNPDLAYVIPAEGGLSYVDLLVVPKDAPHAENAHRFVDHVLKPEVGAALANAVRYGSPNEAAKPFIDRGLLDDPLVYPPPERLAKLPFTKDLGVEVEARYADAWTRVKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU64</accession>
    <name>A0A7W7WU64_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16550" checksum="CACA798BD84380D1" modified="2021-06-02" version="1">MRPYDHPDSVKLIAELQQLFVVRYGEADATVVDPAQFAAPAGHFLVGYVDGVPVACGGWRAREEARPPLLAGDAEIKRMYVVDSARGKGYARLLLAALEQAARDAGRTRLVLETGDRQPEAIALYESSGYTPMAGFGHYKDEPGAHYFAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP1</accession>
    <name>A0A7W7WUP1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="19722" checksum="98BCD09F8C67FE95" modified="2021-06-02" version="1">MIIWLNGSFAAGKTTLAGELLRRLPQAVVFDPEELGITLWKWVPPNDDFQNLAAWRELVVATAISLRRHHTDTLIIPMTLTNTAYQAEILGGLATAGEEVLHVFLEADPTVLIARLDARGPVTDTPVTGQTAREWALERMTAAITAAAHQPSGTLKLRSDHLTTTELADEVLAAAELHSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP5</accession>
    <name>A0A7W7WUP5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031195866" evidence="2">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="201" mass="20644" checksum="9A1B6AA2F36796F0" modified="2021-06-02" version="1">MNRMPAIAVIAIASVVGLAACANPTTTGSPSAESTRGSVSSGATPTSTGGRPSTGDDLDIAKFADKPCELVTPEQLASLGKLRPAKPESDPFGVKCVWPGNDPRDDTSYIVTLLSKGGTFEVRRDNAKDLPVFAEVTVGGRDAFSYDTTDGKSSCSTGVKVSAEHLIMAQSTLGRQDAANAGKPCQASEKLAAIVVSNLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV44</accession>
    <name>A0A7W7WV44_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="19780" checksum="3E32D52379301BAE" modified="2021-06-02" version="1">MRSESRRAVLDAALELVSGGLDAVTISALTARSGVSNGSVYHHFGSRAGVFAVLYEESFRHSVDAMAPALRAASVEAVVRGLVGHYLDWVVANPERARFLYAAPMTVEPVVKAAAFAPIAEWFAGRAAAGELRDVPVWSLDPVVMGPAHECARRFLLGVLDLAVVRAHVMDAVWSSVAPVGIVGTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV58</accession>
    <name>A0A7W7WV58_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_002299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.22" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004398">
        <property type="term" value="F:histidine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="582" mass="64805" checksum="1B0DC1B65D007116" modified="2021-06-02" version="1">MTRIESDTQTFPEVDLPSQDVWSAVPPAPPHPDQFKLGPEALDPAARMRALDGLNAYLDYRRDHLLGYQVNEDMNAYRQDLSRFLTKHVNNIGDPFQDGGLKVNSKIAEQAVLNYFSTLWHGAAYDPRNRESIWGYVLSMGSTEGNMYALWNARDYLAGRRLLGEDGTDRPVLYQEPMIANVNPNAYKPIAFYSQDTHYSFAKAVRVLDLPTFSRYGREHYRDENPLGGPWPDEVPSEGGPEGKPSTYGPGSIDVAALAKLVEFFAGKGHPIIVSLNLGSTFKGAYDDVRQVADTLLPIFERHGLVDRVVEYEKGQSDRRRGFWIHVDGALGGSYLPFLRMAAENPKYDYHPPVPVPEFDFGLRSATPTVPSMDMVSSIVCSGHKWMGSPMLCGVVATKVKYQMQPPDNPEYIGSQDTTFAGSRNGFTPIVMWDHIAKNSYDRQVSLTTNAQRMAEYLEQKLLGLQAQKESTGKPAGWMWIDRTPLALTVRFRRPNSAIVAKWSLSTVSMLMEPGDPMSRRDLAHIFLMASATPEKIDAFISDLHADNAFDDHVAPTIAAPSQTFGGRALSATTHFADRGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV75</accession>
    <name>A0A7W7WV75_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent RNA helicase HelY</fullName>
            <ecNumber evidence="4">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="43"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="280"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="920" mass="101409" checksum="91C6D9CA024A0186" modified="2021-06-02" version="1">MSSASRSPADAYSDARRRQSRPHLAEFLSVLSFELDPFQQRACEALADGHGVLVCAPTGAGKTIVGEFAVHLALSEGRKCFYTTPIKALSNQKFTDLVARYGADKVGLLTGDTSVNGGAPVVVMTTEVLRNMLYAGSSTLDSLAYVVMDEIHYLADRFRGPVWEEVILHLPESVRLVGLSATVSNAEEFGEWLVEVRGDTTVVVDEHRPVPLWQHMLAGNRLLDLFAGETPDGSTRINPQLLRHTDDLQRYHVPWSRGRGPRNGGRPPRGSGFKPPSRVDIVQRLDQAGLLPAIDFVFSRAGCDAAVAQCVRSGLRLNSADEVEEIREVIESKTRDLPQADLMVLGYWEWREALERGIASHHAGLLPAFKETVEELFVRGLVKVVFATETLALGINMPARTVVLEKLVKYNGEAHVDLTPGEYTQLTGRAGRRGIDVEGHAVVLWQPGVDPKAVGGLASTRTYPLRSSFRPGYNMAVNLVHRLGAAAARDLLEQSFAQFQADRSVVGVARRIERNREALGGYAEAMSCHLGDFPEYASLRRRIGDREKALSRQNTSATRAETASSLEKLRKGDLIAVPSGRRTGLAVVIDPGLTPLGEARPLVVTEDRWSGRLSAADFPVPVEVLGRLRLPRQVDVRSPRSRRDLASAVRDSGVVAPRTVRRRSNPDDDAELATLRRALRAHPCHGCEKREDHARWGERYHRLLGETEQLERKVAATTHSLAREFDRIRGLLRERGYLHAAESGPGGEVTEHGLRLTRLYSESDLLAAECLRHGVWQGLDPAELAAVVSALVYEARRDGPVESRLPPGRVADAMTATARLWAELEEDERRHRLDRTRQPDPGFAWPVFRWARGESLEKVLSSAEEYGTELGAGDFVRWCRQVIDFLDQIRDVGGSGDPVGAVARKAVEALRRGVVAMATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW19</accession>
    <name>A0A7W7WW19_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Curved DNA-binding protein CbpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12124" checksum="E0DF9D89254D3B7A" modified="2021-06-02" version="1">MPQPRDPYQVLGIARAATPAEIATAYRALVRALHPDAQHQPADPARLAEVLAAYTLLRDPRRRATYDRQHPVTAPPPDPGSTSIPIRVHPAHPRRQPDLRVGPVRHHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW29</accession>
    <name>A0A7W7WW29_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031146802" evidence="2">
        <location>
            <begin position="25"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="805" mass="85689" checksum="126C2A1E40523849" modified="2021-06-02" version="1">MRQGLVLAAAVVLGLSGTTVTEAAATPGPRHREPATHQAPRCGLTPSTDSRGPDRVASCLQAGVTVAGAVAVGQTTDVAFTVKAQGDQQDVAITAELPAGLAWARVPAGFTVTGSADAAPASGGTWNRITARRDIADGRTLDFSAQVKGVRAGPASINVRARGTGSGTPGGDADTWLTVGGEGFDASLTVAAARESGTAALPEGVTPQPLYPHLRHQSVGTRGLPQPHSDDPDGTPGVRATSCVRGTWNYADHNGNFRQSANFQVQVWDSDPIGDDLLGTVMTGASGDYNVCFDNDDGIGGGGNDVFVRFVAESPLWNVQRDDEEPYLFRTETRDDVADGSTTDFGAQRPVTQNLMPVVELYDQVNAASDWTPGDCWDRLDRECRRIPVNWTPTSNLGDHYCSEEGGPDCPRENEIYLRGNANTSTTTAIHEVGHGVMDDVYDDQYPRTNCPNPHAIQGQSEPGCAWSEGFAEWYPAQVTGAPTYVFPGGGADAGRTLNLEDPTWGTTGWDTGDDTEGRVAGAMIDLVDGGARDERYWDRHGEPATAIWNTFLRHRSANFRDFFVVHRAADGGDVSDARGKASLFQNTIDFDFRDPLGDYAELERPRAIVPHNFGFTTTVAFWQVVAVRPDGGEQNLELFDDRNQTRSLGTGNQPGADTEFIAVDSNRRALGDYYPRVTQAGGAGGYRIELAQGTTQLIDRETFRMAAGDVVVVRDVLLHQGREVTIAVDPATTGQNPELYLVGSVPGQPDTYVRNRAQAVAQSTGGGAGATETITFTAPSTGFYGVVVINRSGGGSYELSRQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG6</accession>
    <name>A0A7W7WWG6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030730601" evidence="3">
        <location>
            <begin position="30"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="85"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="551" mass="59343" checksum="884B5C132D716709" modified="2021-06-02" version="1">MSPSLPLRAAALVSGLALVLTACGGGTSAGPTTSATSPVPGGELTVAVDSEPVSFDVHVSPQDVTGEILRHVFDSLVSIDAEGRFKPWLATSWEVAPNLKSYTFHLRDNVKFTDGTPFDAAAVKTNFDRIANPATKSQLAASLLGPYAGTEVVDPRTVKVSFTTPFAPFLQGASTPYLGFYSPKTLAENADKLGGGGPVAVGTGPFAFTGYTKGQNLVLTKNPDYNWGPEGAAHTGPAYLDKLTVRFLSEDSVRVGALTSGQVHVARAVAPVDAKALEANKDVTLLKSDVPGGNYNIYLNASKAPFDDPVVRKAVQRGINIDQAVKTVYFGQYKRAWSPLSPSTTGYESKLENSWPYDQAEADKLLDQAGWTTKDADGYRTKNGARLVVKWPVMPPPYLREQRDVLGQAIQADLKKIGVEVVRDQPDIGTYIKQVYGGQTDFTDYSWNRFEPDVLWLFFNSASQPGKGGQNATFTKDDELDKLTETGRTTADPAARATAYGKVQQRAVTDLALVIPVYTPVNSAAVGKSVHGLAYTRDSRLSFYDVWLDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWN3</accession>
    <name>A0A7W7WWN3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR system Cascade subunit CasE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01101">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01907">
        <property type="entry name" value="casE_Cse3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24121" checksum="B11AB5784F2CF8DE" modified="2021-06-02" version="1">MFLTKLTVNVRSREFRRDFADVHDMHRTVMSGFPDTDGDIPARQAHGVLWRLEPTHAGYTALVQSHTRPDWAGLPADYLAGPAETRPLRPVLDAVVPGRTLSFRLLANPTRDSRPAELKGRGRRVAHRTADEQVTWLVRKAGQHGFVIPTAVDGRPDVAPSPMPRRTGGKADATITVDTVRFDGHLVITDAEAFTHAIVAGVGRAKAYGCGLLTIAPPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWQ9</accession>
    <name>A0A7W7WWQ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide/nickel transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030802145" evidence="1">
        <location>
            <begin position="32"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="90"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="522" mass="56404" checksum="2F20DD912BF70353" modified="2021-06-02" version="1">MNSLTRRSTFKALAGVALLLSATACQSAVDAQTSAGGTSVTPKPGGVAEVGVNVDLVPGNVFTNSNASITTLVGLVYDTLVEYPREGLDPKPKLATEWKAADEGRTLTLKLRSGVKFHSGRAFTSADVKFSLQSYADPKWNGQLASTAKIVTSVDTPAPDQVVLHLEHPVSNLFDLLQTVPIVDSETVAEIGTGKKFVGTGAFAFESWRPNTDLKFVRNADYWDGTPYLEGVHVRVIPDAQSLLAAVKSGQVQLARGIGYRDAETAATTQGLRTVNLDGAELQAYVGLNATAAGLDDPKVRQAVQYGLDRERILKEVFRDKGYPASLPWTKSSPAFDEGLNNTYKRDVEKAKKLLAESGKQLGEIPLTYVGNDQVFTAIAQIVQNNLADVGIKVKLEPVDSTQFIKQLIGAQFPGLWTTNHSWAQLSPSTLTVSAYPFNARRNASKYSSEAYTKAADAAWKLPSPTGGESKAAYQELSKQLLDGAFLAEIGVVFEQFVIADKLQDVDWSRRRELDLGKAFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX88</accession>
    <name>A0A7W7WX88_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="73" mass="7718" checksum="A824E8F2C7742318" modified="2021-06-02" version="1">MNSVLAIPTSVCAAIGDTTPIRHEVVGDEVRIAFGRNEIDLVLSPRAAHELATRCTIALDILAAPEPDQDVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXC5</accession>
    <name>A0A7W7WXC5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="684" mass="73601" checksum="E161007A39FAD414" modified="2021-06-02" version="1">MTEFVLVEYGDLEGGGFVPYVAEGRPAPPAPYTAVATKLLTNVPQPPEPADDGFRYPMWSLRRVDVDGEPHWCFAVQGRGGAFGQAGMCQFLFAPAAFNPATLWYGAVRLVRADGRLVHPEAGEPSDTWLRPVSAERLSGALTALFAGDSKVVVDGGPVDVAATIGALLSVVPLSVVDGYVWTTCLVRRPVQDSRPLVTGRWPEELPGGNAGLRSWLDRAPEKPGTPVAHPKTPEVVAWLTDLGARDLSLPEEYAAAPTLADLAELIATKQLDIDPADVPHLLAKDDPRLAIGRGRELVSRWAADDPAGAITRLVGSPKLSPQLTEILFDSLLDAHVHAAPGTNPALFPPAAKAVAGWEAVLTRLLRDRFEDRPRMVEFVRDYVIAEGRPLHDGDAQLAHGRWLTALGVSPDDPASGIYPVPTARIVAEIRERRSLGSVGRAFLAAAADPVAQVRVVLDGLDSVPPVVAAEFVALCPDDRQAGEVLTYALDRGQARAGVAWAEKWLLEVHDRVEAGRRGVVLDTGVGHFGRIDHELPASLLVLALRSELAGLGAADALRRKVLTDAVAKLEAGSRRGHAKAKAPAPHLIVHQPVQPAVAQPPARPQTQPQQQPRPTPYPTEPTESLDTRAPWNVDVEEAATKRKRRRLPDLSAHWPLIGKVLIAVLVVALIVALYLLARHMLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXQ5</accession>
    <name>A0A7W7WXQ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase of polypeptide subunit release factors</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="146"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="495" mass="52994" checksum="311DC214E08FFA80" modified="2021-06-02" version="1">MLSDLSGELATRLREAFQAARYDADGVVDVLGPQAHAALGRGEPEAARRASLDSGALGTLIRLFLLGDAEDADAVAKALPGVDLDVALGAEVVRGDGDRLRAGLDIRPYGDDEGSWWVIADLDADQRGGPVPADHVLGVGHASISLARATSRRPVGSLLDLGTGCGVQALHASRHAESITATDVSERALALAAGTFRLNGLDVELRRGEWFAPLRNRRFDQVVCNPPFVVGPPRVDYVYRDSGLAGDDASALVVRQLPAFLTEGGVGQLLVSWVHRRGEDWADRVTGWLPRGVDAWFVQRDVADPALYVGTWLRDAGVDPRSAEGRAKAGAWLDWFAENDVEGIGFGFVTLRRTGAAHGDVVCEDLRHAYDDPLGPESAAWLDRVAWLRAHGDAESLLATRFTVPDTVVLEEVSAPTDEGWESVVRRLHRTDGPGWQQEVDAATAALVAGFRGVLPLADLVALLAYAHDLPLDALTEAAVPIVRDMVRRGMVVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXY4</accession>
    <name>A0A7W7WXY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="90" mass="9978" checksum="C6E2ABE72697DFF3" modified="2021-06-02" version="1">MRNYRLKDLLRQVLGEADGIASVERLKDDKRNNPLRVHFTTGGYKDLSVRNTAPPSGDNHDNPEVVVHRDGSTRQGPTGPEWKRQAGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXZ1</accession>
    <name>A0A7W7WXZ1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="13"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8174" checksum="48F1300EFC3AACE2" modified="2021-06-02" version="1">MRIPEVVISDDMIRLGQFLKLAGLAEHGAHARELVEADEVTVNGRVENRRGAQLHHGDVVAVGGEKARVVANGQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB4</accession>
    <name>A0A7W7WYB4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="182"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="824" mass="92844" checksum="C1392A352E1B558E" modified="2021-06-02" version="1">MAAGESTDSLIRHLYKSNVPAPSALTGFEENVDLVGLWAEPLTPAVERFLDRDLHATPVKVAVGDRYRSYFTELAATVPEFRVWSDLGEHAATRSALRRLEELLTVTTTESPRDLRAVIRDVNHSELTRRVVDVNTEGYGIDAVFPTVEDIFVMPRFRAVGRSSPDDLELVLARHFSTPNATRRPLLLLGHPGAGKSLITKIIAARLPSERFTAVRVPLRHVDANTTITNQVRQALTAATHGRVPWPDLVDQSADVIRVLLLDGLDELLQATTDDRSGYLHDIVEFQRVEAAMGHPVAVVVTSRTLVADRLRIPGATPVLNLEEFDADRIRDWVRRWNAVNFDLPFSAELALRHEDLAGHPLLLLMLALYYADPTVSRDEELSTTELYERLFVTYARREVTKQAGRVLSEGQLAESARDQVTRLSTAALGMFNRGRQDITEADLSADLKALDRIDTSGERVLAEFFFVHAPEAQVGETRRGYEFVHATFGEYLVAARVVDVLRDVAEGAYGRRKVHDPEDDLLRAMLSHQPLCIREPVLEFARDLLSVLDEDELDRIRRTLETLLRCYRTRPPARAHTDYSPQEPDLLREMATYAANLVLLRVHGPFEPPRADKLGITWPDLVNLWRAALTSDNYLAMLDALSLKGGNLVRFSPLQHAGSLFTDVKHARLTGDRSRESLLRTGLALNFAASYLVIDTDDGEAAFEWTQHFLSWLDAAKIRPWDEIPNLITCPPPPTMTVEEIRQHADRALAVVENRKSSWPPDYSEQLSTWSKNLKKAEPIRYTGLYFTFQMTRTFGRIPEDTFEFTRVIGPQRAQEDIPSADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYC6</accession>
    <name>A0A7W7WYC6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="395" mass="42252" checksum="050D370C7599CBCD" modified="2021-06-02" version="1">MPARDVNPAELPGTRAHLDRVSADLDAGFTCLWLVPDALVASGTAEDLLSRLAARSDSARVDPPGALERRVVAAPPPDAGEPPDWAVGHPAFEDPVVTPEPVLVPAIRLVDRVSRVVDDEGFPLAVVCAWEEDDPDAVGALLSRMSAAGGPARALVAARPRDVRSTAPDPLTTRTHWWWGVVGRLDTAVAVAAHRPPGPGLRDLVAHEVLVEVAGPDLDLAADLAVAWDGEPESLADVVKAVDGPPVPDRRRDGARRPPADLLDAWECGLVDLWEGRVRVSPRAVGDRREAVLRSLVWRAQHRALTPVLDVGRAEVEAVFRTRASTAVLAEVSPDPQAALELGPMHWAATTGRRVTLPAAERELLCRLRAARNALAHLTPLSGADLDRLDGVWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYE0</accession>
    <name>A0A7W7WYE0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="135"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="28892" checksum="028529E7EA2827FE" modified="2021-06-02" version="1">MSVVRATALVDVPVATVAGAVVDVGTLGVRVDGGGLLYEGAEFSLVGRSGRVVVTRAGLGGVGVRVVADRSPEFWLGTDVRVTGAGVLVVHEVGWRQPRTVWERVVDVAFWRRIALRLLEDRAARVAKRIEELVEARVVVGAAVVRGDRLLVQQRGFPAEVAGKWELPGGRVEVGEDDRAAVVRECREELGVEVKARQQVGLDVPLKADLLLRVYAADLINGEPVAEEHQGVRWVRVDELADLDWLPADRVLVPALRELLSAQAGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYG7</accession>
    <name>A0A7W7WYG7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein F4559_005566</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="871"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="973" mass="105313" checksum="D3F3E3DDEC421561" modified="2021-06-02" version="1">MLLVGLITGSRLLGTYVNWLWFGEVGFRSVYGTVLATRFGLFFAVGLLVGGLAALNLVIAYRTRPVFVPVSGPDDPIARYRAAVTRRMRLFAIGLPVLVGVIAGTSAQGHWQEFQLFLNAVDFGQVDAQFGHDIGFYAFKLPFYTWLLGWLFIATAISFVGAVVAHYLFGGIRLAGRGGQLSGPARTHLSVVAGLFVLLKAIAYFFDRYQLLFAEHEKFGGASYTDINAVLPAKLILLFIAVFCAIAFFAGAVLRNLQLPAIATVLLVLSSILVGAAWPAVLEQFSVKPNAINKEAESISRNIKATKEAYGVTDDVVETKPYEGKQNVSLEELKSDQATLGNIRLLDPAVVAKTFTQFQQLRPFYAFPEKLDVDRYKVDGQLQDYIVAVRELRTAGIPQGQSDWINQHLIYTHGNGMVFAEASKVNTPAGSGDGGGYPVFEVAEIDQNANLKEGPFGVKQPRIYFGELGSANDYAIVGGRGTGAPGEYDTDESSFTYDGKGGVRIGGLFNKLVFAAAYSQRNILFNSAIGDDSRIIFNRNPRDRVSAVAPWLTVDGDPYPAVVDGRITWIVDGYTTLDEYPYARKTSLGEVTSDSLKGVAAQPDRQIAYIRNSVKATVDAYDGTVKLYAMDEKDPVLKAWMGVFPDTVKPGSEMSPSLREHLRYPEDLFKVQREMLSQYHVDDPSQFFSGVSFWDVPSDPTVDNPTTVEAAQQTNSKAPGDQQPPFYVLAGDPTGDVKKVSFQLTSSLVRQNREFMASYVTVRSDPDNYGKISVLTLNNEAKGPQQIQTQFLTSAQVSSELNLLTQQKTKVVYGNLLTLPVGGGLLYVEPVYIERASQNTSFPQLSKVLVSFGDKVGYAPTLSAALEQVLSGASSQVPDPGNGNQPPSTTTPPTSTTPPPNGTGQSTELQQAVKDIQTALNAIKAAQSSGDFAALGQAYKDLDVATKKFEAASAAAATQTPQSSVAPSPTPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ9</accession>
    <name>A0A7W7WYQ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025359">
        <property type="entry name" value="DUF4263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14082">
        <property type="entry name" value="DUF4263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="402" mass="45615" checksum="6859520F24AD97E9" modified="2021-06-02" version="1">MTRFSSAYRLLGTEFSVADGDFSNLEIRRSENDDNFHFFFDTRANRLITDFVLDDRPRVATLCQVTLIKKDGTYSPRLRFWKKDKSSPQRRALEYTVTEDEVTKIIKATVDTSDGHQNVWKLIHFLQSFTEVDIPDDNFRAVTEDSTQLAGLLESSDRQTVLEAVRIALGGGLTEEDLLIVSNRKAQLAVFKRLLNDPDFFEAERVRREKRGPEAVWQDFFEENTWIFGYGLKLVACEPLDPEKLERITTGANIFTGAGKRADAVMRSKGYVSSLLFCEIKTHLKPLLEKIPYRQPDVYQVSTEVSGGVSQVQKTASKALMGISQVLHDLYEDDGTPTGIQFSAIRPRQALVIGSLDEFKTGGGVNPEKLSSFDLFRHSVQDVEIITFDELYERASFIVHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZN5</accession>
    <name>A0A7W7WZN5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3631 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022081">
        <property type="entry name" value="DUF3631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12307">
        <property type="entry name" value="DUF3631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3631" evidence="1">
        <location>
            <begin position="173"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="40785" checksum="55877053E0D4CF22" modified="2021-06-02" version="1">MSTHNGAEVLDQVRTFVARFNAFPDEHCAPMLALWYAHTWGAEHFYITPRVVLSSAEPGSGKTRVLEVARHLVRTPEMTFSATPAALFRMVGAGPLTILFDEVDAIFDNKGGGNEDLRALVNAGYKRSATVARCKGDAGNMVIERFPVYAPAALAGIAGNMPDTITTRAITIHMRRRRPDERVEAFRERKVEEQSAPVREALATWMEVVGERVGAAYPDMPEGVTDRAAEIWEPLLAIADMAGGHWPETARAACLHFVKAAQTNPTSDRIRLLSDLRTVFADRGVTRMSTVEILAVLHSMEEAPWGDFYGRPINARQLAMELSAYGVKVTAFKNGAKTFKGYVIDGAHGLGDAWARYLPEPKTDENSEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZP6</accession>
    <name>A0A7W7WZP6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="25635" checksum="AC331B561FC426B8" modified="2021-06-02" version="1">MSTVEAVFVVLAGVFAGGINTIVGSGTLVTFPVLLAVGLPPITANVSNSLGLVPGSLSGAWGYRRELAGQKPRIARLLPASLLGGVVGAVLLVNLPDDAFAAIVPVLIAIALVLVVVQPWLNRRLAEVHRPANGGLVLWAGIFFAGIYGGYFGAAQGVLVMGLMGVLMNEHLQRMNALKNLLTAFVNLVAGLVFVFIADVDWLAVALLAAGSVVGGQLGARVGRRLPPAALRAVIVVVGVVAIVQMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZR8</accession>
    <name>A0A7W7WZR8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative O-methyltransferase YrrM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="22452" checksum="8580DD2C6AFC7892" modified="2021-06-02" version="1">MERELADLAALVRLAPLMTEYLPTTADELGPAALVALVDEVLLGSRTVAVECGCGASSVLLARLLARRGYGHLLSIEHDERTAAFVASQLRREGLGHVARVVHAPLARHPAAIADTPWYHPGLVHEEVSTYVERFGLVDLLLVDGPRPGTARYPALPVFRGVLAPGAAVLADDMDEPGGPEVLVRWAEEFDLRFTPHERTSLSTATALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZW5</accession>
    <name>A0A7W7WZW5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2020 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_006632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018567">
        <property type="entry name" value="DUF2020"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09449">
        <property type="entry name" value="DUF2020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="SSF55724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030658437" description="DUF2020 domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2020" evidence="3">
        <location>
            <begin position="54"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4969273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="18632" checksum="1FF061FA6C0038E4" modified="2021-06-02" version="1">MPMNRVPLLALSAVLSLGVLVACTGTSAPGAQAPQSATKTAETTSATPTGPPPTPEPSADGECPYLPSTDVAQANGQLVRKVRLSEGAPTPACFFYADATDVQLSVWVFQGEPTTAKAVVDRAAPIASSNPASSPEGWNGGSVSNDQGAVYAVAKGGAAVVVSSNQQQTIKAKRIAETVVANLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXA2</accession>
    <name>A0A7W7SXA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="78" mass="8843" checksum="A9FE9A47172DAA74" modified="2021-06-02" version="1">MQYTIRLRREMFRKAKRLAGFPSDSAVAKAIGVHRSTVKRILDGEIYPGPAFIAGMIMAFSPLRFDDLFEIVRVKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXM0</accession>
    <name>A0A7W7SXM0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol alpha 1,6-mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_000170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="189"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="367" mass="39663" checksum="65DBFF997A191B8C" modified="2021-06-02" version="1">MRVAIVTESFLPQVNGVTNSVLRVLEHLAARGHKALVVAPGAGDDRHGDTPVVRVPAVDLPRFSSLPVGVPTRRVLTALEMWRPDVVHLASPFIVGAKGLSAARRLGVPTVAVYQTDVAGFAGHYGLGLTARAAWRWTRRLHSQADRTLAPSSWAVDALRDHGVPRVHRWGRGVDVELFHPGRRDDALRRSLAPDGELLVGYVGRLSPEKQVHRLAVLRDIPGVKLVVVGEGPEEGALRRELPDAAFLGFRAGRDLAAAYASLDVFVHTGPHETFCQAVQEAMASGLPVVAPDAGGPRDLVHPDTGHLVTTDAGLRAAVTGLKDPLHRRRLGQAARRRVRGRTWSAVCDELLDHYAAVLDLPERRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXN9</accession>
    <name>A0A7W7SXN9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16075" checksum="EBB74D61D4C595FD" modified="2021-06-02" version="1">MTTFDCGTPALNGWLATQAVDAAKRGTAKTFVWTPIGSDTVVAYYAITPHLVAGEGLTSAQAGGLSAPVPAYLLAKLALDRSLHGQGHGAELLHDALTRIVEAAELASGRLIVVDAIDDRAVEFYRKYDFKSVAGNPRRLVIKVSTVRQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXQ0</accession>
    <name>A0A7W7SXQ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036170">
        <property type="entry name" value="Prob_YezG_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160424">
        <property type="entry name" value="SSF160424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="531" mass="58613" checksum="07932D9377B9E3B5" modified="2021-06-02" version="1">MKAIFPERTDPTGYVVWADRLYPVAEYLVGPFGEVVVVADEDATTLLHNGAESSFQLRPGVRVGNRFATLVEVRDDGTAAVVPGGWRHAGDTYAPDAVEVVPVTECASLFQVRYEVLPAPDYQPAPFLYLPPAYPVPDVSEAEGRYLDEITRALAEDAPEGWTRIDVEVWALGAWQLLTASATTTAGVVHWSPRPMVGQGFTRLRTATYGPSGAWYRADYVVERDGTPRVAYDRKTEPPWRPFYFRPHDEPDFGYARQELLRFPRALGDTPDWLVRAAAELLDLEVGAGTGRLDPWQPALSSDLTSARTFDAVVEGDTPVFHRQPVNADEKQLLLGFLRGGVVVLAGRGHAPDLMHPEREQRVPMTYLTDGRWVWSESVTHYLEHYDIAPDNNFLAHIRHVRYSGTTRLPTALLARATSLVTRQYQGGTAEDVEPGLAAEVEQAYGSAASVARFLGLAPSAYSIGSEVDGALCLVREGDYFVVFWSFRGERRFSGSFDNPGDAATYLIGFFYSYSEALREPVETGGPGDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXU9</accession>
    <name>A0A7W7SXU9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="7">
        <location>
            <begin position="311"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="409" mass="43823" checksum="36BC09F14CC093CC" modified="2021-06-02" version="1">MSSQVETTRQYTPVRRRRTGRVVSGVAGGIADHIGVEVFWVRAVFAALTALNGVGVVAYGLLWLFVPQPPVGTPESTPEPKERQQALGLVALGIGAAVLTGLLTGPVNGWITGPLAVALVGAAVVWREADEAQRRRWRDGARSGLLGSGRSAIIRVGAGVALVAIGIGVLLINNYGLDQLQFALVAVVATLGGVGVLTVPLWLKLINDLGEERRVRIRTEERAEIAAHLHDSVLQTLALIQKQAENSREVKRLARGQERQLRDWLYGRDAVEGDSRPTTVSAAVAKAAGEVEDAFALSVQQVVVGDCELDHNLVALMNAAREAMVNAAKHAGVGEISVYAEVEPEKVAVFVRDRGKGFDPDTVSEDRHGLADSIRGRMDRHGGEVRLRTAPGEGTEVQLMMPRRAEART</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYK5</accession>
    <name>A0A7W7SYK5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045592">
        <property type="entry name" value="DUF6461"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20062">
        <property type="entry name" value="DUF6461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="310" mass="33289" checksum="C9740A7C9C9A1485" modified="2021-06-02" version="1">MDDATDHYADLLDNGPLPDEALCLTAVRGFSVDEALRRFDGFPSARTETLADAGRTSVDAFPDLLPLVVADEVDGWVLLAEDNGWHGSSAEMLARLSKGTVAASAYWNVDFDSSLTLAIDGRVHECDFISEHESDDPALAPFLAGLPFDDAERMCAASLAFVERVSGVRVTDEWVRAPHPVSVVASAHRFVASAGWIEANAPELVGLDIGPGIAARVAGEGSRVEWHRQALETLWARCLPVDPDGDRVARLQAHVRQRDADRGPEQRLSALAHAAAAREALDAGDLDSALFNACCADPGGWEGLRESLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYN2</accession>
    <name>A0A7W7SYN2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA(Arg) A34 adenosine deaminase TadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14259" checksum="17CA91C2A9038AA6" modified="2021-06-02" version="1">MTHLHRAIALAAEARASGNPPFGSLLVGPDGEVLREERNTSLSDNDITAHPELKLARWAARELAPEIAAGTTMYTSCQPCGMCTGAIERSGLGRVVFALSEGQLLTLKPGGGFPPVPQDGPDLFDEARVPVAGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ14</accession>
    <name>A0A7W7SZ14_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="544" mass="58513" checksum="EB6B1ABB64FAEDD1" modified="2021-06-02" version="1">MDADAIVVGAGLAGLVATAELVDAGRKVILLDQEPEASLGGQAWWSFGGLFLVDSPEQRRLRVRDSAELALQDWLGSAGFDRDTDHWPRQWARAYVEFASGEKRAWLHDMGVRWFPLVQWAERGGYLADGHGNSVPRFHVTWGTGPGLVEPFERRVRAGVERGLVDLRFRHRVTGLGTGTVTGEILRADPVGRGEPSSRDVVGEFELTAQAVIVTSGGIGGNPELVRKNWPARMGTPPARLLSGVPDHVDGRMLQVTREAGGSVINEDRMWHYPEGIANYAPVWSAHGIRILPGPSSLWLDATGRRLPVPLFPGFDALGALEHIVKTGHDHSWFVLNRRIIGKEFALSGSEQNPDLTGKDARQVLKRALPGAVAPVEAFAKRSSEFVFAATPAELAAGMNALTGTDAIDPAALDRLIRERDRQVLSGLGKDMQINAMREARRFLTDKLIRVVEPHALLDPKAGPLIAVRLSVLTRKTLGGLHTDLSARVLKDDGTVLDGVYAAGEAAGFGGGGVHGYRALEGTFLGGCLFSGRIAGRAAAAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZC4</accession>
    <name>A0A7W7SZC4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="55" mass="5593" checksum="757E88D680515F26" modified="2021-06-02" version="1">MTIPTVRTDDQALTGLASGDPGTVTAGDPGLDARLAAWAATERAALDAQGREALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZM1</accession>
    <name>A0A7W7SZM1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Streptogrisin C</fullName>
            <ecNumber evidence="3">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001316">
        <property type="entry name" value="Pept_S1A_streptogrisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00861">
        <property type="entry name" value="ALYTICPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030741763" evidence="2">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="19095" checksum="0A1239C7D46A02C8" modified="2021-06-02" version="1">MRTLLALLLSLTTAAPPIAAGATLTTSTGARCTNGFNVRGHLILSPRCGPVGTTLHAGGVLVGTIKAVRTTYAVADLAPGQTQSPTVVGSTGTVAGATETAIGGQVCYFSQRGGKRCGTVQRKNATVNYPEGTITGLTKASLCPLPGDEWAPVLGGTQAQGHLLGGSGCTAYFLPLRPVLSAEGFTLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZR7</accession>
    <name>A0A7W7SZR7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="131"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="28803" checksum="359D7C998E106ED6" modified="2021-06-02" version="1">MSIVPHSPAPAAPVHGAPCWVDLATADPQATLDFYAGLFGWLYVVSEGRTLALVDGLPVAELVQAEAQSAWTLYLNTPHTRATADKALSLGGTILTEPTDLTTVIGDPSGAITGFRHVTPDWEFGTDGHGAFAYAELNTRDGDAADAFFHELCGFEVTQIGDGQAVDYTTWAIEGDTVLGRQRMGAAFAPETPPHWMVYFTAAPEIGTDSVARRALELGGRVTIEPYDTPFGRVTVVADHAGAVFSVLDPTRVTPLADDEIGAEVDDPFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZS2</accession>
    <name>A0A7W7SZS2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031562391" evidence="1">
        <location>
            <begin position="28"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="489" mass="53337" checksum="7191BB5B51D34131" modified="2021-06-02" version="1">MRSVIRALGGLTAVTALVVGTAVTATAAPESRPAAVEWAACPETTEVECGTLRLPIDWNSPRGAKFDLAVARRKAADPAKRIGVLLINPGGPGVSGVNFAFDAAWWFGPDVLDRFDIIGFDPRGVARSSGVTCDPALLAARPGRPTTAAEFDALGRYNRRLAADCRARTGPLYDHLDTSAVIDDMDALRKSLGEKKINFWGASFGTSLGQQYAERYGDKVRAMSLDSVMDRSLTTSRFNETQAAAAEDSFGEFVKWCDRDERCALHGQDVRKYWSGLLAKADRGEVVDPREPTRRITAAELVHFAFDMLYYPDWAPLAEQMISLELTRPQPVPVAFQPAFCQDWQFRVRSYPEYAALVRRANQVAPSLRGGMLGLYAISGCVGLPDATNPQRRVDLSDSPKILLSNSLHDPSTSYEWAVGANRQNRNKTVLLTYEGWGHVTYYHSTCMSGASDKYLVDLTLPAAGTRCAAVDPTVFAAKASTTARLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZW0</accession>
    <name>A0A7W7SZW0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycolate phosphatase-like HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="24530" checksum="7F21CF473EA75491" modified="2021-06-02" version="1">MSGHTLVLWDIDLTLLDARGLGHQWYRTALREAAGLDLRVVPSFPGRTERAITMELLTAHDLEPTDELIEALHAELVGVAAREYHALSGLGRVLPGALAALEALSGRDDVVQSLVTGNLVEIARFKMEAFGLHPHVDFEIGGYGHVSEHRPALVLEAKRLAAAKHGREFRAVVVGDTPHDVDAALHHDAIAIGVATGRSTVDELREAGAHVVLTDLADTAAVLAAVLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T011</accession>
    <name>A0A7W7T011_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">F4559_001462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="185"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4964103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="356" mass="36780" checksum="0B9633609F016B36" modified="2021-06-02" version="1">MVVAGGGTAGHIEPALALADAVKRLRPDARVVALGTERGLENKLVPARGYPLELIPPVPMPRKPSPELLKLPLKVRESVKRTREILERVGADIVVGFGGYVSLPAYLAARGRVPIVVHEANAKTGLANKVGAKFAERVVAAVPDSGLSDAEVIGIPLRHSITTLDRAALRAQARAHFGLHPTAPTLLVFGGSQGARSINNAVSGAAPAFARAGIGVLHAHGPKHTVAVQAVPGAAPYVPVPYLERMDLAYAAADAVLCRSGAMTVAEVSAVGLPAVFVPLPHGNGEQALNARPVVAAGGGLLVPDEELTPQWVADNVVPLVADRARLAAMTAATLGSGHREADEVLARIVLEVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0K2</accession>
    <name>A0A7W7T0K2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030785881" evidence="1">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="48359" checksum="0D0EF144E97C66E5" modified="2021-06-02" version="1">MRRLGILVLTIVAMTTTVLPARADTVTRYEGEIDGAKYRVMVPSSWNGTLVLWSHGAYGVEPPTIALTDQPATEEYLLSRGYALAASKFRQPVGWSVEDGPRDQLALLDWFRRTVGPPRRTISAGESAGGATATVLAERNAHRFSGVLTLCGAMAGSGAYWNSGLDVMFAVKTLLGADFALVKAIDPAANEQAAYDAVDRAVDPAGAARVALAAALGDVPAAFDPTVPAPTELADRLYWARVWVQYFRTAAVGTARADLERRAGGNPSGNLLVDYRRVLDRSGAKGLVVEAYRTAGLDLDADLDRLAAAPRVTPDLRAVAYLGVPLGFDPWPVVTVHNRYDGVLPLSNETVYARRALRPDNLRQYAVDRAGHCRFTASEEITAFESLFHRLDTGTWRADDPATQNTRAAAHGPERQTIRNPLTGQTVVVGPAFTTVPRTPYPREFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0M9</accession>
    <name>A0A7W7T0M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14608" checksum="D8965C6B91BE1818" modified="2021-06-02" version="1">MTYSIAQAAERSGLSIDTLRYYERIGLVEPPARTTGGRRSYTDEDLNWLAFLTRMRTTGMPIRMLSEYAQLRNRGPAAAGRRMQILCEHRASVRERIAELQVSLSVLDYKIAHYEQIEQSLVQEGITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0V9</accession>
    <name>A0A7W7T0V9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polar amino acid transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030597485" evidence="2">
        <location>
            <begin position="25"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="73"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="33546" checksum="B2878574D11624F5" modified="2021-06-02" version="1">MSKIKITGLVAAAALSLAACGAGAEAGPAGGAEDKVVASGKTINLAPEQNRITADKVDAIAAKVPEAIRKSGKLIVGGSSGTQPPLRFYATDDKTPIGVETDIAVLIAGVLGLEAQLEVASWENLFVGLDSGQFPLGVSNITVTEARKEKYDFATYRLDTLAFEAKKGSGFKFEKAEDVAGKIIAVGSGTNQEKILVEWSKQAEAKGLKPVDIKYFQNASDYYLALESGRIDAYLGPNPTSSYHVVTSGKTEIVGTLSGGGAIIGKIAATTKKGSGLIEPVAEAIDHLIKTGKYQEVLDRWGLKNEAVEKAEINPPGLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T179</accession>
    <name>A0A7W7T179_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen fixation NifU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15959" checksum="5BCD31B60D14793E" modified="2021-06-02" version="1">MQLNQMYQEIILDHYKNPHGRGLRDPYDAESHQVNPTCGDEVTLRVRLDAGTVADVSYDGQGCSISQASTSVLTDLVVGKPVDEAFVKLDAFVELMQGRGQVEPDEDVLEDGIAFAGVAKYPARVKCALLGWMAFKDAVARSEGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1A5</accession>
    <name>A0A7W7T1A5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_002077</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="68"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="370"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="704" mass="74668" checksum="03D833E601C2EBD5" modified="2021-06-02" version="1">MFAARATSLVKLVGLCLMAGVLVAALLFPVIGGMGLASNRAADTVDKTSGELTNAELPLVTTVLDMNGQPIAYLYDQYRIPVASKDISDTMKAAIIAIEDKRFFLHKGVDWQGIARAAAKAGVDGGASQGASTLTQQYVKNYLAFVVGKGEDEAYEKATEATLGRKISEARIATQLEQKMTKDEILTAYLNLVPFGNGTYGVGAAARAYFDTTPDKLTVPQAAMLAGLVNEPSRLNPGADPEPAIKRRNTVIDKMRENGAFGSDDKVAKEKADEYKATDIGVVADLRLLPNGCVGAGDGPIYGFFCRYLIDYLERSGLPFEELRRGGYTVHTTMDPVATRATKEAAESQVPKTAPGIANAMAVVQPGQDKHRVRALAANRDFGNNADAGQSAFSIPAEVTKFGAGSIYKVFTAASALERNVTGIDRPIEVPNTYTSKVYKNGSQPYTVKNAGTYKDRMSLTEALATSPNTGFIILEEKTGLDNVVDMAYRLGLRDSMQGVNEAGDPLKQDGSNGPSQGDSYKRNNSGSFTLGAGPTSVLELANVSATLVSGGKWCPPTPVEKIVDRDGQDVALKEAPCDQAVAPEIANAMVTAMSQDVKGVGTAAGAARDWDRPMLGKTGTTENHWSVAFMGATMQFAGAVMTFTDGVRPQVICNGTPPRLCGNNDAGGVFGGQVAAPTWFRAMRVIHGTSPVQPLPAVEARYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V2</accession>
    <name>A0A7W7T1V2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxylase-like metal-dependent hydrolase (Beta-lactamase superfamily II)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26032" checksum="C989FFD7248EC4F2" modified="2021-06-02" version="1">MLNQVADGVWVRQSEWVWSNAVVVRGDDGLVVVDPGIGGADLAELADDVDRLGIPVVAGFCTHPHWDHLLWHSRFGDVPRYATAACAQSAGEVRERARAMAEQSASGVPLDLVGLLTPLPAAGGVLPGEVVEHDAHAVGHAALLLADRGVLIAGDMLSDVLIPLFDPRRTGQPAAYATALDRLGEAARHVDVVIPGHGAVAVGPEVAARLEADRAYLDAVLAGGDPADARLEQDWLAGPHQANLAQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z2</accession>
    <name>A0A7W7T1Z2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="432" mass="44183" checksum="FB7B734C40C4C601" modified="2021-06-02" version="1">MTGLRRFAVVWAGQLVSVIGSALSTFVLGVWVYLETGSVTKFALIQFCAILPGILLAPWAGVLADRVDRRVIMLVADGGAGLVTSLLFTAVSLDSLATWQIYLAAALTATLNSFHVIAYSALVPALVPKDQLGRVNGLMQLTQGVQIAAPLVAGALLGLVGLRGVLLIDVVSMVFAVGSLLLARLPEEAVRPAGAAGRDRGVGAGLRWLRSAPGLLALCAVFGVWNFLFAVAGGLVQPLILSFATPATLGVLMAAGGSGLFLGGLAMGAWGGPKRRVHGIYLGLGLGGVFLVLHSLAPSPWLIGFVAPAFLATLPLMNTCCVTLVQTKVDPAVLGRVLAGVRTLSTAAMPVAYLLIGPLSDGIAEPLMTGDGALAGTVGALIGTGPGRGIALVFLVVGVLMLALAAVAWSRPRLRAVDDLPDAASPLERTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2K1</accession>
    <name>A0A7W7T2K1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding Lrp family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="18732" checksum="DB555439D8F49CB2" modified="2021-06-02" version="1">MTDVAELDSVDWRILEALQNDATLQNKALADLVGLAPSTCLQRVRRLRELGVITGFHAVVDPRTAGLPLEAVVSVNVRPHTRPVVNAFRQFVMAQPETRSLFHVSGTADFLVHIAVVDSTHLQAFLMDKIASRTEVRNLTSSVVLERVETRALTPPGDRRPSHRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2N4</accession>
    <name>A0A7W7T2N4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tol biopolymer transport system component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF11" evidence="2">
        <location>
            <begin position="463"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="807" mass="85438" checksum="7BFFA8FB29E54364" modified="2021-06-02" version="1">MTDEPTGAAEEPAWNPLNGRIAYTLRSYGQSFLRVLDDSVVGSPVLGGGQAGWQGRWPSWKPDGSGLLFLSFDQTCSCTADPAVEKVYQADLGGGVPVETVPGLLLAEDRSVSSPAWSDVGRPRLLVSRTSASTRNTADLQDIRPDGVDPRDLGLSVLREDPGIAQDPNRLFHPRPGYDPWTQRQGYSPDGRRLVVTRFEDVDGVRAQRLWVVDADGSDARRLPVADRRTADWEFDPAWSPDGKFLAFARRSPGGVRPDAGGLSRVAVVDVENGAVVGNLRPSVDIPDLEDTQPAWSPDGDTLAFTRGVVSRDGNGVEVRRNHIWTARARTLDQQRDLSAAVCGFACEVTDDSAAFRPDSRSLVFNREFDGLVEVSLSDNGCRVLLPGNGTCSAPVTAPPTGPFQPRDAAYSPDGGRLVLTTRREGPAASPEELVVLDNGRLDRITRGLPGRQKEPTWQPSVDLKVEAPQDVPEVVVGTKTTIDVTVTNRGPAASPDTALTFAVPEGVRIDAIRPDQGTCEARCDLGTLSEGQDVRVSVDVVGTVPGRWRLTWTVTGGVLDVKPQDNSTGTGVPVREPEKPPPPPPPPPPPPPVAGPGLTVVVQPNPSYVGGRAAATFTTRNGGDGFATGLRLDFVLPQGVPVAALPPGCTAAGCALPDLAPGASMITQVLFAPDAPLETTVRGVLRTTGTDADPNDNAAQAPMRVLLPRIVAVPPIGEPGFVTSVRGLDFPPGTPVRLAWSPGITAAAAPTIPRPDGRFTAQLLILHKDATGPRTITATGVGFRPATTPFLVVPGTVGPPDMVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2P8</accession>
    <name>A0A7W7T2P8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase (DIM6/NTAB) family NADH-FMN oxidoreductase RutF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="16332" checksum="45C7286D5B3C473D" modified="2021-06-02" version="1">MAGFPTGVAVVTAVDADGTPHGMTCSSLCSVTLLPPTLAVCLRRGSPTLAAIQRRNFFVVNLMHDEARITAELFASGEADRFDRVRWQAGAAGPHLPDDAHAIADCSVRRTEPVGDHEVVFGEVLGAGVSEMPKPLLYGMRRYARLWTEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2X2</accession>
    <name>A0A7W7T2X2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymethylenebutenolidase</fullName>
            <ecNumber evidence="2">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DLH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="238" mass="25739" checksum="73C1EAE9E8019461" modified="2021-06-02" version="1">MTAHDHLSDAGEFRLVSADGARVLAYRAVPRRPTGAGVVVLPDVRGAHEFYRGLARRFAGQGIAALVVDHWARLAWNDDRSDDFDGLSYVSRLDWAAARDDIRAGVDLLLSGSLGPVSTVFALGFSLGGAMALGQAALEPRLRGAIGCYARPAECRELIPRMSGPLLVIGAGDDFFTTVEDNLAFDRELTLAGVEHEFHLYPDAPHSFVDGAIPEQADNAADAWQRVVAFVREHSRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T308</accession>
    <name>A0A7W7T308_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fermentation-respiration switch protein FrsA (DUF1100 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="entry name" value="PTHR34853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="343" mass="36226" checksum="CF2F24FFB7FB4328" modified="2021-06-02" version="1">MTTTESPGTIVGSEPVTVPRCPKAWRIHYRSTSAGGTPNVVSATVLLPDLPWNGVQPVVGFAVGTHGFADHCAPSHLLRTGNEPEIELIVAGLDQGWAVVVTDYEGLGTPGTHTYTVGKAQGHAMLDAVRAAPGLDARSPVALWGYAQGGQAAAFAAELQPTYAPDLPVRAVAAGAVASDLPAIIRRNDGVYTGPALGSLVGHATAYPDLPFDELLTDRGRAAAALIPGLDAPDLVARFLGTRLDDFLTVDVLDHPLWRERLAESTAGVTGPVVPTLLYHSADDEIVPVAFGERLHERYRAAGTPVHWHLLSDLAHFPAALDSAPTVVRWLDERFAEPPPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T356</accession>
    <name>A0A7W7T356_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L1-like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="2"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26556" checksum="B1E47F369DE3B17F" modified="2021-06-02" version="1">MAIGDSFTEGIGDERVDGSPRGWADLVAAGLAAGGPPVEYANLAVRGRLLEPIVTGQLEAALALTPAPTLITFNGGGNDMMRQGVDGRRLVDLTEHVIRSCAAAGVRLVLLSGADPSDGLPFGGTVRRRGKALTAAVAGLARRHDFVFVDVFNDAEIRRAPYWSPDRLHLGPDGHRRVASLVLAALGHDVAAHAVAPTPADPRRLSTEVRYYREHVLPWLARRARGRSSGDNRLGKHVAWTTVETPHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T366</accession>
    <name>A0A7W7T366_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biotin transport system ATP-binding protein</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="226" mass="24805" checksum="44C4C10D242B6781" modified="2021-06-02" version="1">MIELAGVGHRFGDWVVLADVDLRLTGHRIGVIGANGSGKSTFARLLNGLLVPTSGRVLVDGLDTRKRGREVRRRVGFVFQDPDVQIVMPTVAEDLAFGLRHRDLDRAEIGRRVDAALDAYGLTAFRDHPAHLLSGGQKQLLAIAAVLVLEPDCVVFDEPTTLLDLRNRHRIAKLIHGLDRRVVVVTHDLDLVSDFERVLVFDRGRVVFDGPAADAVAEYVAMNPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3D8</accession>
    <name>A0A7W7T3D8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HAF family extracellular repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030657543" evidence="1">
        <location>
            <begin position="25"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="375" mass="38152" checksum="330FE2C05DD26291" modified="2021-06-02" version="1">MRRPPTLAAAVVLVLTAFPVPASASATVVDLGVLPGGDASRANAIDPAGTVVGHSTTTGGAVHAASWAADGRIADLGTLPGDTSSTADGISDTGIVFGHSYTDDGPTHAVRWVGGVIEELRPLPGHVKTVANAINARGTVVGVSVGTDYTDQHAVAWDRSGRTIALPALPGDPASAAISVNDAGVIVGHSGPYTAINDQHPLVWAPDGRVTRLSHEGADHGIAVGVNNAGTVAATIVDRDNHLNVVRFAPDGRGSHLGTDVEASAIGEDGTVLGSRSDLGRLYGARWRAGSTEAEFLSHTYRIAAVNRSGIAVGGTKSGPRGSRPMLWTLDENPSVDLPTLGGGKGIASDVDDRGTAVGSSPLRGGAWRAVKWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3E2</accession>
    <name>A0A7W7T3E2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="155" mass="16753" checksum="430B22A4942506FB" modified="2021-06-02" version="1">MRMSEGVEWAVHCCLGIAWAPDDRALPAARLAAYYSLPAPYLNKQLQALTRAGILASTPGPRGGFRLARPLHAITLMDVVCAIEGTDPAFRCTEIRLNTPEGRATVDPGVPCAVDRAMNRAELAWRRELAGQTLADIHASVHPDVIAGARTHFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3K2</accession>
    <name>A0A7W7T3K2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADH-flavin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="45" mass="4601" checksum="0884D0F030285D1F" modified="2021-06-02" version="1">MHIGIFGATGVIGGRVVDEALERGHRVTAFTRTGARVPAEPGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3M0</accession>
    <name>A0A7W7T3M0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F420-dependent oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019951">
        <property type="entry name" value="F420_OxRdatse_Rv3520c_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03559">
        <property type="entry name" value="F420_Rv3520c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="349" mass="37209" checksum="A877793F092975B3" modified="2021-06-02" version="1">MRLGLNLGYWGAGNDSANLELAKEADRLGYSVVWAAEAYGSDAPTVLSWVAAHTTKVDVGSAIMQIPARTPATTAMTAATLDTLSGGRFRLGLGVSGPQVSEGWHGVRFDKPLARTREYVDVVRTALRRERLTYDGAYYTLPLPDGPGKALTLTAHPVREHIPVYLAAIGPRNVELAGEIADGWLALFFSPERAGEFLAAVETGRRRAGRTLDGFDVVPTVPLVVGDDPAACADVVRPYAALYIGGMGSRDRNFYNDLASRMGYAAEAAEVRERYLARDYDGAMAALPFEFLDATSLLGPKERIADRMAAFAQAGVTTLTVSPMLQDLAQGIAALRTATDALDLAGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N9</accession>
    <name>A0A7W7T3N9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030741911" evidence="1">
        <location>
            <begin position="36"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="400" mass="43654" checksum="B926ED8DE543BFD9" modified="2021-06-02" version="1">MKPDLLRNHLARRDVLRAAGVAGIAGLVGAAPASAAAHPDDKPFDYADPANLSDWAPSRYGPADQRGTLNEVTPAKTAAALALLKPHRDVVTYNLGELMWNGFPAYKTDPRRTWEQRLTIHGYQPPPGFREQGGVLISPEPLGANRISVHEERFEAELSAKHPKPLALTHQIGSQLDNLNHVGAGELFYNGRRGTDIARGHGTIRLGAEHMGPVVTRGLLLDVLGVKLAHGRDLGEPAGDGSPVLRDDYRITVADIEDALDFGDIDRIEPGDVVLLRTGWNRLLARRDPADIARWEASRGMPGIYLREARWLAKFRPAIVGGDTWALEVLGNKVNEDGTAFPVHQELIMRHGIRIAESYVLDGLAADRVYRFVFIVTPQYAEGATAGNTPAAALGQPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3R9</accession>
    <name>A0A7W7T3R9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032722">
        <property type="entry name" value="Deaminase_XOO_2897"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14440">
        <property type="entry name" value="XOO_2897-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HintN" evidence="1">
        <location>
            <begin position="422"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="694" mass="72423" checksum="07DEB2F8893B0091" modified="2021-06-02" version="1">MAFNAYDELVTDGGTTNTYDALNRLVGTGSRTLSYEGLTRTISAAGTDTYSNLPDGTPLGVRQGTTRSLSVTDLHTDVVATVDPTTGMLVSSRAYGPFGDVQSTTGTPPALGYQHQWTDPTTGDVNMGARWYQSGTGAFSSRDTAALDPRDLLNANRHAYAASNPLTSIDPSGNWWTPVPTPVLPIGVAIPVLAAGGAAVGVGAMGTVAAIGAAAVVGGFIGYALYEASVTRSVKNKFKISINRGGRGGIRYPDGQKPVTGNIGTVVTPDIVSFPSDWGSSWGDEVSAWVGGWATQSAPAVSQAVLEELARAARVRDNALTEAARPELSQTISGSVQALIDAAASAPAIALGNLVSGGKEQAFAPTDTQQATPFLPAQEYLDDSCHTGGRLGTDPFGQVTRGASIWTCGDAPGAGSSGDCVSNSFTPETPVLMADGTTKPIEDVNVGDEVMASDPVDGRTESRPVTATIVGAGEKTLVDVTVDADGDGDSDGVITATDGHPFWVDSAAEWREASELHAGDLLRTPAGSTVWILAVATHTLLKRVHNLTVNGLHTYYVLAGLIAVLVHNSSGCGPVAYGSTELSRIAVKHRIQAGIEAGQNVAIYSIELPNGRIANLAFVNTVRRTHSEGHADEFFAGIGLDPRSVRDIYSERNFCLTEGHECAGRMSKFVNARLSWSFEHGENAAAAIRRYIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T423</accession>
    <name>A0A7W7T423_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-dependent dehydrogenase (Short-subunit alcohol dehydrogenase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="248" mass="25846" checksum="99B4FD3B01475879" modified="2021-06-02" version="1">MTSTSAGNTLAIFGAGPVTGLSLARRFGREGFRIALVSRTKRTQDEVAAALAADGIEATGFTADVYDRTDIAAAVDAITAAYGRIDVVEFSPGGGTMGEDIVPISGVTPENARSAFDRFTLSAVALVDAVLPAMVERGHGTILFTAGQSGLHPVRFLGNAGMAQAALRNYYLNLNALLAPDGVHVGAVNVGMLIEGSVPHQVLAADPSFAVETVHPDVLAEHFWQLHHRRGQAEVLVGDLGRVAAEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T478</accession>
    <name>A0A7W7T478_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="34432" checksum="992964BE5DA92F62" modified="2021-06-02" version="1">MRREVVGAWLLLAGFAALWLGVAWDGQWHVDVGPDTFFTAPHLMFYFGTALIGTTSLVVVLGGRRSDGAVRVFGFHAPPAFLVAGLGAAGHLVYGAADLWWHTIYGFDILESTPSHLSLQLAMHVQAVGVTMAFAALRTTTSGRWGLVLAGAFGVGSGAILLDGAVFGVKLGMLALGGIAAWTVCAVMGITRSVRWAFALASAFLVVQAATFLFPPVVTGLYADGIGQPIRDDALGIPLVALAMPVAFPVVAALAAGVVSFARKRYPRPDLAMAVAGAVVGLGAALPRVIMDDDSANAVLGVVAVTVLGAVAGRFGWPCAVLMRRLGPKEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T490</accession>
    <name>A0A7W7T490_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10969" checksum="E8158EA8DC899BB5" modified="2021-06-02" version="1">MTDSYTMSPEELRGHAARLRKVQDRLDTALKAAGQVSLDPLAYGLLNPGIAVMVTIVSRVGVAALDQGEQAVADTIAEVRKTADLAEEVERGTWIAFRGMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4H9</accession>
    <name>A0A7W7T4H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031480029" evidence="1">
        <location>
            <begin position="32"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="336" mass="36254" checksum="75EC9528A07DAFA0" modified="2021-06-02" version="1">MATRHHRTLSAALATVAASGLLFVPVQSASADTAHAARVGVLEGTRLYVKEGSIFDPWVEQADGVRKFQLEGDRIGVLRTNGQLDVKAGDLGPGWHTVNTDSVTDFQLSGDRIAYTEGNDLYITEGDFGGEIVYQVDAPTRKFQLAGDRVVVLTPDGTLKAKEGDLGPGWAVLGTGVTDFEITDRRIVFAQGGRLYLREDLAYPNEPLYQTRDVVKFDADGNRIGWVDSKGVFRAIFGIPYFASAVTISESVTDFRLDGERIAYVEDGDLWAQEGSLWAASTVQETDIDGFDLDGDLLAVIKDGALLLKDGDLGPGWYVADDDSALAVDLLAASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Q5</accession>
    <name>A0A7W7T4Q5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="626" mass="67006" checksum="45A2AA8C7B9A2F4B" modified="2021-06-02" version="1">MAVRDIFVGGDGEDSRGGLTWADRVRTFDRARRIAAGVGGPVAFVVGQFVMAREAYFGQRLGKGIEAGYDVPDGWTMRAYDPELPWHFTDLDVLDAPGDFVQVFKDGNTHNANTSIPVGDKEPVPTIADNRGVPTGRPTGVWISTRDVANADKPLFRVVRVWRGGRALTFGDRAAVPSAYDPYNEVWEARSFETLGSDGTHTWTQLTPGEKWGTAPAPASGRLSVFSPHGNPVDQWGGITVLAHRSAGGNGMDLGLLTVRQSSGWRIDESVKVIGGGLAAFKIRGGCADGRIEAKVDVFSPYYPVVDLDPHTGFDTFTGLEISPRWDLRVTHKPYYEIDAAHSTGQSDALRITSGARVAGLLVRGRTTGGTPCYVRDPGHSAVGRPVPAAGVVLDGLVVERDFAVYLGGLQYQRAFVVNGGHDTVRNCVISGRVYGQRTPSQLTGGIKVVGAEFHHGRQMIPAAPDGSFRYPSRFDDRTRDFSHQHPDGKNRDAIALEITMDGKAEVRGCVFDASHGAALNLTKVTGFDATRDGCLVTGCTFVTGTQPGSLPVAVLVDDRGDAGTGVRLRDNVAVGYPASGGAQWTPTGADGKVRTAIRLEDLATGGPRVAENSGWVRQAFATCYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T0</accession>
    <name>A0A7W7T4T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35745" checksum="4ACDE7AE070620A2" modified="2021-06-02" version="1">MEVVQRKAVERSALRKLNPAGSEHTAVVYLTKRGEYERVVGRLTMAEIWLRTPKELFTVATSPQEDTFDLRLPSREEAFSFAASVRATWRVTDPVAAVKAQLTDPSPGVRRLLEERLREHTRGFDVEGNAEAERRFNLDYADRAVVVSDAVTITGCTVVLNLDEATTAHIADRTLVVRERQKHEYDKERDERKREREREDTKHDLALQETRMKQYADALQSGDHNALALLLAGHGEDANAVVQIIMQQRQLEHSAAREVLDRLLAANLVNRKDVGRIIESAGTALIGGVSDVRTPKSVESARPDRETDPDDEGFEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Y7</accession>
    <name>A0A7W7T4Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045778">
        <property type="entry name" value="DUF6204"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19707">
        <property type="entry name" value="DUF6204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="12343" checksum="860AB89404FF1591" modified="2021-06-02" version="1">MEHTYRVMVRGRFADLDEAGRARLRADAHRHDMLTSGFSEQGALAYDRSLDFFSFRVQLRAEVESDDRAVCDRGLRLAAQAVEALGVDFRDLRASATDVDLIKVKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T576</accession>
    <name>A0A7W7T576_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="4">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="534" mass="60821" checksum="A8FB66C87D316EE7" modified="2021-06-02" version="1">MLIYFGRDGGVPGWRVFWVPQDAVRGGVRRAILADWADLAVREDEAGVRAGDPIFLSPDHRVDPLLSQYGQSKRFREYTTETRRNYATDICLFLTFLSGRGRVWTAATERDVEDYEHWRRFAEGNPHRVGGSKWDRELAAFASLYRWAVINHYVRRSPLAMKQVVGREGAVLTVPAARAKDARPSNVHWLTPRTWRRWIEVGLRGHSRDGAPEPGWVGRLEDRNVAFVRLLVTSGLRRAEGGSLLTFEVPVRQVDGARYYRGKVAAEVTRSKKPRTFYVAADAVGEIEAYVESSRAWVVRQAQKKGRYDRLRGRRVVTEVTRGRKPMVRWRDETGVTGERALDDLTARERMRLFAEGPRGLEPLWLWLNEQGLPFQVHSWEGVFTAANRRCERVLTPPNRMGFDPHQVFAPYATPHSARHSFALFMLVVLNTFMDLKYGLSPEERRDFRQLYGDPWFMVQCLLGHASRETTVDRYLAPVADLQLRSMLAGATEAAGPTAAPMPELDVVFARIARESEGIQDLDDRMWTAGGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T596</accession>
    <name>A0A7W7T596_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase YjhB (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16063" checksum="FDE4A09943ED8E34" modified="2021-06-02" version="1">MTTTSPALGPLVGVYGLVGHDERLLVVRDPDATAYRLPGGLVRAGEAVEDALRRNLRTGLDACAAHLDFCAVVELREQYAGTQPTVFELALLFDVTLTDPSAVRVDHGEARWATDIELGHLDLRPSALADRLRSGGPTREQPWWPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B1</accession>
    <name>A0A7W7T5B1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_004175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4966816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1238" mass="137019" checksum="BAC1CEDA882304EA" modified="2021-06-02" version="1">MSTDTDPTTTSSHAGLDNDLTDALVRTRRFFTRAEVSSDLRTLHKIGGRQADEFYRDRWSHDKVVRSTHGVNCTGSCSWKVYVKDGIITWEAQQTDYPSVGPDSPEYEPRGCPRGAAFSWYTYSPTRVRYPYVRGVLLEMYREAKSRLGDPVLAWADIVEDSERARRYKAARGKGGLVRASWDEATEMIAAAHVHTIKTYGPDRVAGFSPIPAMSMVSHASGARFVSLLGGTMLSFYDWYADLPVASPQVFGDQTDVPESGDWWDAGYLIMWGSNVPVTRTPDAHWMAEARYRGQKVIAVSPDYADNVKFADEWLAAQPGTDGALAMAMGHVILREFFVDRQVPYFLDYVKRYTDLPFLIRLDEHGNVHRPGKFLTAADLADHAGAENAAFKTVLLDSATGGPVVPGGSLGFRYGEQGAGRWNLDLGEVDPLLSVHGDEAVVVELPRFDSAGGADGSMAVLRRGVPVRQVGGHLVTTVFDLLLAQYGVHRDGLPGDWPTGYDDPEQPYTPAWQEAITGVPAQAAARIGREFAANAEESRGRSMIIMGAGTNHWFHSDTIYRAFLTLTTLTGCQGVNGGGWAHYVGQEKCRPITGWSQLAFGLDWSRPPRQMIQTAYWYLHTDQFRYDHFGADTLAAATAGGQLAGKTTADVIAQSARMGWMPSYPTFDRNPLDLADDAERAGVPVGEHVVSELKAERLRFACEDPDSPENFPRVLSIWRANLLGSSAKGNEYFFKHLLGTDHSLRAQETPPEARPKDVVWHDEAPVGKLDLLLSLDFRMTSTTIFSDVVLPAATWYEKHDLNTTDMHPFVHSFNPAIAPPWQTRTDWAAFQAIAQVFGTLAEKHLGTRKDVVATPLLHDTPDELATPHGRVLDWKTGDCEPIPGVTMPKLTVVERDYTAIAAKMGALGPLADSLGATTKGVTFQVEREVEYLRHKNGAIRGGPADGRPSLVRDVHACEAILALSGTTNGHLATQGFRTLEQRTGTQLADLAAEHEGKQITFADTQSAPVPVITSPEWSGSETGGRRYSPFTINVERLKPWHTLTGRQHFFLDHDWMTELGENLPVFRPPLNMHALFDEPRIGEQGSLGITVRYLTPHSKWSIHSEYQDNLFMLSLSRGGQTIWMSQEDAAKIGVHDNDWIEAVNRNGVVVARAIVSHRMPEGTVYMHHAQDRLIDVPRTETSGKRGGIHNSLTRLLIKPSHLIGGYAQLSFAFNYLGPTGNQRDEITVIRRRNQEVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B7</accession>
    <name>A0A7W7T5B7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLATT_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025325">
        <property type="entry name" value="DUF4231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040884">
        <property type="entry name" value="SLATT_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14015">
        <property type="entry name" value="DUF4231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18181">
        <property type="entry name" value="SLATT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="SLATT_1" evidence="2">
        <location>
            <begin position="157"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="32182" checksum="1BAC5D6691721DA6" modified="2021-06-02" version="1">MSEEKARWVWRRQGVWSATATALKNRVERIRRWSMIALVGAALAGVTAAFVQEAAPVVARWITGFAVVSVASSVYLRGRLGKDAVAEWTTARRTSESLKSEVYRFLAGTAPYHDRDATRLHDRAEEIDRQAKDLDPHTTGIRVADRELPRVYDIRSYEDVRVRAQITGYFKPKAAQSDRRLRRFGRLDFVIGYAGAALTAFATVFFGDVSAVIGALTTVGATLAAHVAESELRYLAVEYTRTAAELDRLCERRAIGGVASDDEFVDACEQVIVSENQAWVARLGRSNGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T0</accession>
    <name>A0A7W7T5T0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="29"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="177" mass="19199" checksum="8178BF98118808EF" modified="2021-06-02" version="1">MTDAGPWTSVSMPYVSGHRGDTWGAEAAEHGGTGTQKLLSVDEVTASATVADMLGLAAGEPVVARRRLILFNDHPVELVDSYYPVDIARGTRLAEHRKIPGGAVALLADLGHRPRRVREDVSARLATPYERTTLELDDPSCVLLLARVLLTGDERPVEASVMTMVADGRRLRYELTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5T4</accession>
    <name>A0A7W7T5T4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-6Y C5,15-methyltransferase (Decarboxylating)</fullName>
            <ecNumber evidence="8">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.132" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="39911" checksum="DFEE96F52611CBDD" modified="2021-06-02" version="1">MITVVGIGADGWGGLPDATRHLVATHDVLVGSGRQLALVPGQYERVKLPSPLLANLPALLDDLAGKAVCVLASGDPMFHGIGSTLVRLLGAGSVKAVPHPSSASLACARLGWALDAVDVVSLVGRPTAALVPFLHPGRRVLVLGGVPAEVAAVARDARITVLEQLGGPLERVHHDLPSADPLHVLAVECGEGGYALVPGLPDDAYEHDGQLTKREVRAVTLALLAPRPGELLWDVGAGSGSLAVEWSRVHPTCRAIAVERNESRAARITRNARSLGVPTIRVVVGESPDVLDFEAPDAVFIGGGVTAEGAVETCWRAVKTGGRLVANAVTLESEAVLTRWQRELGGSLTRIEVSRDAAVGGFTAWRPQLPVTIWSVRKEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L6</accession>
    <name>A0A7W7T6L6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="16"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="205" mass="22071" checksum="4D55E88C9DF29ED6" modified="2021-06-02" version="1">MSTPDFAAPASADRVDHVAEAARGNGLTVDVVDTVADARRLLNDTLPTDKTIFTAASETLRLSGIAEDVDESGRFRSVRAALRERNADRDPEQVRLEAVTPDVVLGSVHAVTEQGHLVIASATGSQLAPYAYGAASVVWVVGAQKVVPDLETALHRVRTYTLAKENERCLAVYGQPSVLSKILIVERELFPGRARLVLVREAIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N7</accession>
    <name>A0A7W7T6N7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] synthase-3</fullName>
            <ecNumber evidence="5">2.3.1.180</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Antibiotic biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="4">
        <location>
            <begin position="108"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="3">
        <location>
            <begin position="238"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="34242" checksum="8B7E320618C3528A" modified="2021-06-02" version="1">MGSRLAGVAVHLPEHRMSTAEVERRLGPFTPPAGLVTRLTGVESRHVMRDDEQASDLAVAAARKLLADTGTAPADVDLLLFASASQDMVEPATAHIVAAKLELSCPVMDVKNACNSVLNAIEVADALITTGRYRRVLIASGESPSRAVRWNVDSLQAFLRAFPGYTLSDAGAALLLTPGDGVLGSGFTADSTQWEVGTLPGGGSRHPRDPEHTYFDLDGARLKSAFLSLGGGVLDATLDRLGLTWADFAVICVHQVSLPYLGVFAERLGVPTDRLVITLPEHGNVASASLPLQLATAQRLGRCGPGDLVALVGLAGGVSLGMVVIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T796</accession>
    <name>A0A7W7T796_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030626718" evidence="1">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15599" checksum="B4049AF06474FC06" modified="2021-06-02" version="1">MKFIRTATAAALAVAALFGSFATASAASATETAIGCTDGSTPSGFPDQKVVKSVTTPVFGRRIELWYSSNTCAWGYLGNANSGDPLWVDRAANIAQANAGIWTQLGITQLNGTAGITRAYNDNRRVMRACAEVWDGFAVKVFCTGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7D8</accession>
    <name>A0A7W7T7D8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="67" mass="7511" checksum="26B573C37CA356FD" modified="2021-06-02" version="1">MAERKSVLLRLDPAVHDALTRWAADELRSTNAQIEFLLRRALTEAGRLPTGTADQPKRGRPRKDTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7J8</accession>
    <name>A0A7W7T7J8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHAD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CHAD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4968033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="496" mass="54539" checksum="755272C06439F0C6" modified="2021-06-02" version="1">MSTPKTATSAHETERKYEAPDGTSLPELADLPGVAAAAGPEQQRLEAVYYDTTDLRLARAGLTLRRRTGGDDAGWHLKLPIGVDTREEVRLPPGRAAKHPPRQLGSLVQVHARGSALAPVARIRTTRRRWQLVDERGRLLAEVVEDLVSAQSALDGSAVDSWREVEVELGERGDTALLDRVEERLREAGILRSTSSAKLTRLLADRIAPAPRAGSGSSAGDLIVSYLREQADAIKHWDPRVRRSEDDAVHQLRVATRRARSALQAYGEVVDRERTRALTDELKWLAGVLGEARDLEVLQARFAGAVAELDDALVLGPVSAQLTRHFAPLETAAHEASVAALDSPRYFALLDAIDAVIADPPTTALARKKAAKVLPESIKATHRRLARRVAAAHDDEGLHEARKAAKRLRYTIEVAEPLLGKRARKYRTLVKHVQTLLGDHQDACVARPVLRELGAKAHLDGENGFTFGLLHGLEAYRAHRYETAFRALWPKLAKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7W3</accession>
    <name>A0A7W7T7W3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="8">
        <location>
            <begin position="104"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="53328" checksum="67F6072CA3E23A1F" modified="2021-06-02" version="1">MFKNPDEVLKFISDEGVKFIDVRFSDLPGVMQHFTLPAAAFDADAIEEGLAFDGSSVRGFQSIHESDMLLLPDLYTARLDPFRIEKTLNINFFVHDPFTREAYSRDPRNIARKAEQYIAESGIADTAYFGAEAEFYIFDSIRFDTQPNASFYEIDAISGAWNTGREEEGGNRGYKVKYKGGYFPVTPTDHYADLRDKMTLNLQDSGFTIERAHHEVGTGGQAEINYKFNTLLHSADDVMLFKYIIKNTAWQAGKSVTFMPKPLFGDNGSGMHTHQSLWKDGVPLFHDEAGYAGLSDMARHYIGGILHHAPSLLAFTNPTVNSYHRLVPGYEAPVSLVYSQRNRSACVRIPITGDNPKAKRIEFRCPDSSGNPYLAFSAMVMAGLDGVKNKIEPPAPVDKDLYELPPEEARGVKQVPATLDAVLDSLESDHEFLLEGGVFTPDVIDTWITYKREQEIDPLRLRPNPYEFHLYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Y6</accession>
    <name>A0A7W7T7Y6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RDD family membrane protein YckC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="157" mass="16709" checksum="0F9676B7EA0926FC" modified="2021-06-02" version="1">MSKWTGSWLSGPRAALEPGADSNDGTAQRWKGERLGLPKDGPGSVASTGRRAFAIIVDFALAAGVAGLFTYPDLPRNWSLLAWFAITTVAVAFFGFTPGHALFGLRVARIDGVALVGVPRAALRTALIFPIIPAVVWDADGRCLHDKAARTVVIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7Z8</accession>
    <name>A0A7W7T7Z8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030744930" evidence="4">
        <location>
            <begin position="50"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="630" mass="67555" checksum="0166CF8BA623032F" modified="2021-06-02" version="1">MTLLSIAAVVVALVWLRRRFPARKGVRRWPALAGVVSILALQAVLGAPAANAVGCGDAPNPERPGSGMVGAIDPSIGNGVKDSPYLVYGYAGMVWHAYQPDCLKLPDTAAVIDTWMGNELFNVGKNIVGATNALHYTVVGQGLLQPLDDAVKAGVQKVYDNVYLRWFGLVALVLAMLMFRQIWSGDLAAISKRGMWALAAMWLATSTLALPQFYNLLDSTLVTRTSEIQAGFIDVEEGKDKLDILPSRLHDSVVYQSWLRGVFGSPEAPQAAQFGSRLLADQAWSVQELADHKDGDQAAMEAKKNDYKALEKELGSARGAFTGADGGRTGAGFLALLQAVAFSLFQLFAKAAVLLAQLLLRVLTLAGPLIGLVALIHHDLLRKVGRAAAVTVFNVLVLAVLAGTHALLLQAIFNATGLSLLTRTLLALMLTVVCFMIGKPLRRMWQMVEMSVGGASSALPMRGGLLSRLRRKKDAGPTPQDEFWDQVRDTDPDSPEAPRRDGRVRPEASGPVSSGPVVATAQRLDRRPPAVRGELDGRPRQAALPSGGGQAALPAATRSRVVDTPPVVDRGWDRQDDAVLVPSRVSNGHQRLAADGPVLPGPRRAETEVVAGRQVHVIYRPSRGLEVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T848</accession>
    <name>A0A7W7T848_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="285"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="372" mass="37380" checksum="D29E08F07278680C" modified="2021-06-02" version="1">MNDKQMQGSLEKLSSGLRINKAADDAAGLSISQGLQAQIGGLKVAARNAQDGVNVVQTADGALNESASILQRMRDLAVQAANGGSQDATAQGAAQTEFSQLQSELDRIAKTTSFGGQKLLAAGTTGGTAYTGTFQVGANNTTDDRISVNLDSSVFGAAGTKASFTATGGTYTSAALDTKTITATQGSTTATVTLATPADLDAVVSQLNGDSTFAAGFVASKAGGELKVEAKTAGAGTIALTGTAALTGTATAGTDGPTATGFDSTGLGVGSTVKVSDTSSAQSAITAVDKAIRSLSTARSELGAYQNRFEHTINNINVQVENLSASKSAITDTDMANEMVSFTRSQILSQAGTAMLAQANQAPQSVLQLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C8</accession>
    <name>A0A7W7T8C8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="11852" checksum="5FFE367119D27A6A" modified="2021-06-02" version="1">MTYVIAQPCVDVLDKACIEECPVDCIYEGDRMLYIHPDECVDCGACEPVCPVEAIYYEDDVPDEWKEYTKANVDFFDDLGSPGGASKVGKVSADPAFVKALPPQASHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8P4</accession>
    <name>A0A7W7T8P4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="294" mass="31700" checksum="168EBFF97F97DD7C" modified="2021-06-02" version="1">MRIAVTGATGFVGGAVRRAAEARGWEVHAYGSRAWDITTGPLADPPEVDVVVHAAAAVTDWGGAGQVRRVNVDGTRHVTRTWPRARLVHISSASVYDPFTPTVDATEDQAPVARYLTPYGATKAAAERVVAERPDTVVLRPHAVYGPGDPTLLPRVLAAIRGRSLILVGDGRTRQSLTSIDNLVDATVLACTGPPGVYNVADAEPVVLVDALRDLLRERGLGHVRTRHLPTNLAWPLATVAERVWRAARKSTPPRLTRYAISHLAHERTLDLTKARERLGYDPGPTSFAGAAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z2</accession>
    <name>A0A7W7T8Z2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="43107" checksum="977276359C58B505" modified="2021-06-02" version="1">MGTSEWGEVPVGRDAQRWVTRRGLHDVLVVGHTAASCEHLFDALALIESDRRIQIAFTRAPDVFGGGVEELFRAAGGVVLPWEQAIREPFRLALAAAYGSVHRVHAPLVLMPHGAGYAKGFPTATGGTQVYGLDRQRLVRDGEPVARLVALSHDDQLDVLRDQCPEAVDVAEVVGDLSYDRLVASEPFRDAYRAALGVDDRELVVLASTWGSGSLFGMHFDLIPRLLDELPPSRFRVATLVHPAVWFGHGPRQVRAWLSDCVEAGLLLLAPDVDWRAAIVAADHVIGDHGSTTAYAAALGRTVLRVEPPARLSIVENSPQARLGAVARRLRSDVPVVDQLRDAAADPGFGAEIRAALTSRPGLATVTLRRSLYGILGLAEPGAHRAPAPVPVPPRWYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C5</accession>
    <name>A0A7W7T9C5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030708567" description="PHB domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="62"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="295" mass="31922" checksum="B9E49F5723025BA0" modified="2021-06-02" version="1">MNRRFTVALLATATLAVSGCSIANTTASEVALQYGAGMFDSRVFVQCVPTGTRELNDIADDHYYYPAGQRDFTFGPDEGLDSAQLTSTTSDAQEISVSGTVKFTLNTDCAEFTDPSGKTWPGGRLQMFHELIAAKYEAAPLEGGESMREGWRKLLRNYVGAALDRAADNEALKYGWLQLYTDPAKKAQWEQDVLGQLPEILKTLTQGVELISINAVLLQKPDIQPALMSGLTDKQAAELRNQAAEVDKKAAENFPGGLAGYQAYQQQQAINQAIKDGKVQVLPVPQGSPIIVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D2</accession>
    <name>A0A7W7T9D2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">8-oxo-dGTP pyrophosphatase MutT (NUDIX family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="28471" checksum="598024CE31167123" modified="2021-06-02" version="1">MRELPPELVVPPSMVPDEAPDPPVVPRDAATVVLVRDGSAGLEVFLLRRVVGMAFAGGMTVFPGGGVDRRDADAPVAWTGPPREWWAGRFGCTPESAAALVCAAVREMFEESGVLLAGPSPDTVVADTAAYASARAALVARELSFAEFLNAEGLVLRADLLRPWANWVTPVDEPRRYDTRFFAAVLPSGQRADGETAEASDAVWQRPADAVADWRAGRRLLLPPTWAALADLAELGTAADVLAADREVEKIIPKLVRDGAVIRVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9K1</accession>
    <name>A0A7W7T9K1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module HigA family antidote</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="11240" checksum="ECFDDC0949A0A448" modified="2021-06-02" version="1">MTEDIMLPVHPGEILAEEYLEPLGVTQHRLAIAIGVPPRRINEIVHGKRGISADTALRLARYFGTSERFWLNLQARYDIEQQKDRVAHELARIQPLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9M6</accession>
    <name>A0A7W7T9M6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="733" mass="75778" checksum="9C3F1452C59D74C4" modified="2021-06-02" version="1">MALTIGELVGYLRVDASAWRRGLGEARATLARVARDSAGDLDKLGERARSAGDRAGQAFVGLALSITKVAGAISTVQGAVPTVVAMGGALALLPALGVAVKVGMFAAQVGMTGFGDALAAVDDPAAFAESLDKLSPAARQTALAVRDLAPAWKDVQRATQDALFAGVADEVRELGGAYLPVLKTGLSGITAEFNTAARGTGAFLGQSQQVQTVSGIFGQVRQAIGNTTSALPALVSILLDLVAVGSEFLPNLSGGFGDAAQRAAEFVRAARESGRLREWISSGLSTLGDLGKVFGNLLAIARSVFGAFDTGGASLLDTLLRVTGGVREFLESFEGQQALAALGELLGTVSSTVTSVLLVALRQLAPLVVTLAPAFAQLATQVGSTLVTALTLAGPLLLGLAGFLSENIGWLGPLGIGLYAAAQAFGVVSTAVRVLNVISSANPWALLIAATVVLATLIVTNWDTITAAVGAAWRWLVDVGKSTWDWIVGIVRGAAEFLVDLFLNWSLPGLIIKHWDSIVSGVRTAVRWVLDAVGWLGELPGRVGAWFVRVKDSIVDRWSDAVAWVRGVPQRILDALGDLGRLLYDTGANIVRGLINGFGSLAGAIRDKLLGLVKAAWDSVLSFFGINSPSRLAAEAGRYVGEGLVVGLGRMSGKVDRAFLDMAALPPIPKTVIPAPRLAAPAGSDWASGLSTFDPHLGSGGPVVHVTNHYPQAEPTSTTVNRSLQYAGALGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9M7</accession>
    <name>A0A7W7T9M7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="130" mass="14164" checksum="AAE60713CC5E3864" modified="2021-06-02" version="1">MSEGVDVVEAVRHEWPLGPYLKSARESAGLSMQETARRAGVSHAKVRDLERGYKIKDGKQYPVGTTKSTVECVADAVGADVAEALRLVGITKDDPSRPGRRPKGLDLSAVPYEELLAELGRRLSKLPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N0</accession>
    <name>A0A7W7T9N0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13541" checksum="F0CD98A11A5E20C8" modified="2021-06-02" version="1">MLYYWPIAATIAIVLVTLGALIYYLRRSTGQHGNPNGAAFTVEDAQQQAAPKGRGQPNDVQHRPSTLWSSGETSQRVEQVIADDDLSMLVRRYVLHAEARRDALAGAWHSAGTGASRSIVEPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N7</accession>
    <name>A0A7W7T9N7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="303" mass="34278" checksum="5372B7FF91AA3F07" modified="2021-06-02" version="1">MQHTSTVAPSAPPPAPDSRTFARAFADVRDAWRNRELWGHLGWQDIKQRYRRSLIGPLWITISMGTTALALGLLYSQLFNQQLPTFLPYVTAGFVIWNFILGVVSEGTDVFIANEGLIKHLPAPMTVHVLRMVWRQVLFFVHNLAVYVVVVAIFFPALTKPYTMEGENVVQPGIGWDILLAIPAFALIVVNAVWVALLFGIISTRFRDIPPVIHSFINLIFFMTPIVWHTGVLNKVTNGEGSWRVLIAELNPIYHYVEIVRAPLLGHQQSWHHWVVVGALTLVGWALALVALRNYRARVSYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9S2</accession>
    <name>A0A7W7T9S2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="32093" checksum="A62B94C4B546754C" modified="2021-06-02" version="1">MSRGEAMVDATSEVEAVRAAARWTVGAAAALLAAMLAGVQLSAVGRLEEFTAARGGGSVIAATAGLLGAGAVLWLAARVLVSPGWTLNRLAGLELTAPETWRTHWARLELESRQALLSPTRDLKLAGLYRHQRALFVASVELSEHGRTTVAGSLLDGEETTYRADHQGDEDRLNRRRALADALAARIVETIDVADTHRRYRVLVRALPWLGATAVLSIAAFIWATSPPVGVPVTAPTPVRVEFAGDRAALAEAGVPDGCAGVVVAGVAVGGTLVEPVVSSVERADCRVDRVRLPKRVAVVVPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9X9</accession>
    <name>A0A7W7T9X9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="50007" checksum="C887F48FB15E530D" modified="2021-06-02" version="1">MNTIGSHSSPVTPEVWDQQEMRDALARREISAVYRLLRRHGVSQRQIAALTGQSQSEVSEILKGRQVMAYDVLARIAQGLGVPRGYMGLAYDEATAVRVAASADSPHSEEDESVKRRKFLAHAAAITVGAAVFGTDSGSWAASPAQTPAPGRIGMTDVRQVEAATRALRTLDYQYGGGSCRDAVVAQLSWGQQMLGANATELVRERLYVALADLHNLAGWTSFDTGLYDSARNHFGQALGLAKQGRKEELVANILYRMGRVYLHQNAPDDALKVFQLGQLAAQNSGSELAVGILCANEAWAYAKMGSDDQALKLLGRARDEFARADIGEAPAWAKFFDANDLSSMIGTVHTELAQTVDTKYTRTAIPALSKAIGGFGDDMSRSRSFNLTSLSINHLLEGDIDHGARIGRQAIDMSEALKSVRTKDRMRPLQREADKRKNNPEARELAERVAQFTGSGDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z6</accession>
    <name>A0A7W7T9Z6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaA</name>
        <name evidence="15" type="ORF">F4559_006643</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="213"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="14">
        <location>
            <begin position="425"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="221"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBB4969284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="523" mass="58380" checksum="73010987700D49E9" modified="2021-06-02" version="1">MSDHQSDLGRVWEQVVQELAASTLSPQQRAWMRVTRPIGLLDGTALLAAPSEFAKEAIERALRDPITAALSRRLGRAVSLAVKVDSPDPVNPPTTPLPVLPAPVVPITPPPVNGIERPVPLLPDKPEPEGPTGEAEGEEVDEQAEELAAVTEIWPTFSRNTAPSGTPFTRPANPASSQTRLNEKYNFDTFVIGASNRFAHAAAVAVAEAPARAYNPMFIWGESGLGKTHLLHAVGHYAQRLFPGMRVRYVSTEEFTNDFINSLRDDRKVAFQRRYRDIDVLLVDDIQFLEGKEGTQEEFFHTFNTLHNSNKQIVVSSDRPPKRLETLEDRLRTRFEWGLITDIQPPELETRIAILRKKAAQDRLAAPAEVLEFIAARIERNIRELEGALIRVTAFASLNRQPVDVQLAEIVLRDLIPDSHAPEITAPTIMAVTAEFFGVSLDDLCGPGKTRVLAQARQISMYLCRELTDLSLPKIGQTFGGRDHTTVIHADKKIRKEMAERRRIYDQVQELTSRIKQQARHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA02</accession>
    <name>A0A7W7TA02_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT superfamily N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="FR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="23193" checksum="2831F233CE8A86AE" modified="2021-06-02" version="1">MSRRVVGVTLDNLEHLSKHSRTCVFWELAPHLKEQAEEYGDTEFEKEAWVSNVLLEWGSCGRLIYCDGIPAGSVFYAPPAAVPRSLAFPTSPVSPDAVLLTSLDVLPEFRGGGLARVLVQAVAKDLTRRGVKAVEAFGDNQPDDEKPSCVIPADFLLQVGFKTVRPHPRWPRLRLELRSASSWKEDVEAALEQLLNTVTISTAEPSFRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF6</accession>
    <name>A0A7W7TAF6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine/homoserine/homoserine lactone efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030892192" evidence="6">
        <location>
            <begin position="23"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4969431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21024" checksum="6E58AEBA128BF9B5" modified="2021-06-02" version="1">MISAAFVLTCLAVSLSPGQTLAVVIDQSLRAGRSAGLAAVAGNTVGLVFWAAASTLGLTVLVRTSQVAFLVLKVVGAVYLCWLGVQAFRRAGRVKPAAERKGSFRAGVVANVTNPKAAALYLALFPQFLPADGGTFADTATLAVVQMAISFSYYSLVVLAVHTVRRFLDRPAVRRALDRLTGFALVVLGVRMLTLTRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTR9</accession>
    <name>A0A7W7WTR9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hemL</name>
        <name evidence="9" type="ORF">F4559_000137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4962778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="429" mass="44778" checksum="02514DDA49C7A598" modified="2021-06-02" version="1">MTATRSQALFERAAEAIPGGVNSPVRAFHSVGGTPRFMVRGDGPHLWDADGNRYVDLVASWGPMILGHAHPDVVEAVRAAAGNGLSFGTPTEGEIDLAEEIIARVAPVERVRLVNSGTEATMSAIRLARGFTGRRKVIKFAGCYHGHVDALLAQAGSGVATLGLPTSPGVTGAQAADTIVLPYNDVEAVRQAFAENAGEIACVITEAAAGNMGAVAPKYNAELREVAHEHGALLVMDEVMTGFRVSRSGWFGLEAVPGDLYTFGKVMSGGLPAAAFGGRADVMARLAPAGPVYQAGTLSGNPVAVAAGLATLRAADDEVYRKLDANASRLGALFTAALTEAGVAHRVQFAGNLVSVFFTDDEVVDYAGAQAAQTWRFPPFFHALLDRGVYPPPSAFEAWFVNAAMTDEDFALIADALPHAARAAAEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTW2</accession>
    <name>A0A7W7WTW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-1,2-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031439142" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="65"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1258" mass="135151" checksum="18D1871179359EDF" modified="2021-06-02" version="1">MRTIAVTAAVVVSALVAGWVPAIASPGRPDVTTFSSSFEEGQAQPRWTSTAETGPDGSPLVSGVDGTDSTGLPGDVTSRVVALAASGENTGSGELKENLVDGSVASKWLVFAATGWVDFGFDGDVAVTRYALTSANDVPARDPRDWVLRGSADGKAWTVVDSRGGEAFRSRGESRTFDVATPAAFRWYRLDVTANSGAREVQLADVRFSDGSTTPAPRTMLTVAGRGANGGYNTRPGMGFTGTRALRYAGTHTGSGRGYAYNKVFEVDVPVAADTELSYLVFPTHVDLAYPSTFVAVDLAFSDGTYLSGLGASDQYGFPLSPRGQGEAKSLSTNQWNRITSAIGAVAAGRTVRRILIGYDNPRGPASFAGWFDDIALGPAVRTSSGRPSDHVLTTRGTNSGSSFSRGNTFPATAVPHGFNFWTPTTNAGSIDWIYEYARRNDDANLPRVEAFTASHEPSPWMGDRQTFQVMPVAGTPTADRAGRALPFRHSAEEARAHYYGVTFENGMRTEITPTDHAAVFRFTFTGDTGNLVFDNVDNRGGLTLDPATGVVTGFSDVRSGLSAGATRLFVYGVVSRPVASSGRLTGQGRDAVAGYFGFDTSVEKTVELRLATSLLSVEQAWRNLSLEVSISDTFEDVRSRARRLWDEVLGVVEVEGASPDQLTTLYSNLYRLYLYPNSGYENTGTAAAPVYRYASPVRPGGPSSPTHTGAQIVDGKIYVNNGFWDTYRTTWPACTLFTPKRTASLVDGFVQQYRDGGWISRWSSPGYANLMTGTSSDVAFADAFVKGVDGFDYVAAFDAAVKNATVAPPSQDVGRKGLETSIFAGYTSTATSEGMSWALEGYVNDHGIASMAAALHERTGDPAYAEQAEYFSRRAQGYAHLFDPSIGFFQGRRPDGSWRVAPAKYDPREWGYDYTETNGWNMAFSVPHDGAGLARLHGGPAGLARKLDEFFATPETATHTGSYDGVIHEMTEARDVRMGQLGHSNQPSHHIPYMYVYAGQPWRTQEKVREILSRLYAGSSIGQGYPGDEDNGELSAWWLLSALGLYPVEMGGGVYTIGSPLFTKATVRMDNGATLVVNAPGNSSRDVYVRSLRVNGKEWTSARLPHAEIASGGTLDFEMSSKPTSWGVLPDVGVAGTPWRDVTSTARMTGSGRVGPLVDDTSRSSTSVTWVQADLPSAESVAMYTLTSGTGSGDPASWVLQGSEDGVTWSTVDSRSGEVFPWRRQTRAFKVPVPGKYRHYRLEFSTAATLTEVELLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU81</accession>
    <name>A0A7W7WU81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="39941" checksum="AA3663CC56AF1417" modified="2021-06-02" version="1">MIDDPVRVARAYLSRVAEPPAPALAAFVAEHGPVRAARLVRDGMVPTDVDRQTSARRARDRAEEDLRQMAAQGGRLVIPEDDEWPDWPFQALTMAAARRLRCGLAPLALWVRGKGNLAESTDRAVAVVGSRSASGYGLHVAAEFGYGLAEAGMTVVSGAAYGIDGAAHRGALAAGGSTIAVLACGVDVAYPAGHERLLAEILEQGLVISEYPPNHSPARHRFLTRNRLIAALGDGTVVVEAGRRSGAKNTAATTSALGRVLMAVPGPVTSSSSSGCNELLRAGDAVPVTSVAEVVESVGRLGFDLVEATGNRDVPPQGDAMRVLEALDPMFPVPTRAVAVESGVELARVEALLPELEAIGAAERIDMGWKRTPEGTWRGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUB4</accession>
    <name>A0A7W7WUB4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="17082" checksum="DCABD963515CC49D" modified="2021-06-02" version="1">MIENVHARQVPDAPTLLDRMMELWPADHWPPLRLDRPLGVGADGGHGFVRYTCTAYEPGARVEFTFAPGLGLVGTHTLYVVPGGLRHVLRGKATGSMRLWWPLAIRWLHDALMEDLFDNAEKAAGRTPARPVRWSWWVRKLRKFPLRPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF3</accession>
    <name>A0A7W7WUF3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF397 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007278">
        <property type="entry name" value="DUF397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04149">
        <property type="entry name" value="DUF397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF397" evidence="1">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9862" checksum="5687A12B85D85A7C" modified="2021-06-02" version="1">MTESAPIYDDKAHVRGNLDLSAAGWIRSDEGAEDEDEHVEIAFVEHSDGVTYTAMRNSAHPDGPVLVFTPAEWEAFILGVKDGEFDEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUF9</accession>
    <name>A0A7W7WUF9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain containing-hemolysin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_001624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="218"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="281"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4964265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="427" mass="45405" checksum="8AE14A31D0B74D12" modified="2021-06-02" version="1">MLILSGLLAILALTAATGYFVAQEFAYMAVDRGRLHHLAENGDKAAARAYRVTQRLSFMLSGAQFGITVTALLVGYVAEPLLGTGLADLLGLPPAVAVPLSMAVALVVATVVQMVLGELFPKNLAIAEPEALAKALAPSTVVYLRIAGPVIRLFDAAANRLLRAVGIEPVEELPQGATPEDLKRIIGDAGAEGHLDPELSRLLDRGLGFRELVAEQAMTPRVSVRVVRAEEPVSRVVDLLDTGYSRFPVIGDGTDDLRGIVGLAEVLTVPPRERTTTPVGAVAVPALVVPATLALPGVLERLRSERRQTACVVDEFGGFAGVVTLEDLAEELVGEIHDEDDVVAESIEEIVDGVWRVPGRMRLDEIADATGVELPLHDAYDTVSGLLLHRLGRVAEPDDRVEVDGVSLRVAEVTRNVPGVVVLEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA9</accession>
    <name>A0A7W7WVA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="186" mass="21115" checksum="0D3E394249AD8F94" modified="2021-06-02" version="1">MARGLLLLDVDGPLNPYAARRHRRPAGFTTHRLTSTGHWYTGREARRHKGLRVWLNPDHGALLRALAERADLEPVWATTWAHQANTRIAPVIGLPELPVIEFSERDLDPLHGWRDGGSWKWSAVARYAGDRPLAWLDDELDDRYPRARARFEAARAATPTLLCDVDPRVGLREEHAEQVEKWAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB9</accession>
    <name>A0A7W7WVB9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catechol 2,3-dioxygenase-like lactoylglutathione lyase family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16017" checksum="0A75B4E7B7E441FA" modified="2021-06-02" version="1">MALARPNVGHVGLNVTDVDRSIGFYRQVFGFEVLAEGKEDGRRFAFLGTADRLVITLWQQAEDASDPSRAGLHHLSFQVDTVDEVRAAEATLRDLAVTFRYDGVVPHGEGADSGGIFFFDPDGIRLEIFAPSGAGAADAPTAGAPTCGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVG2</accession>
    <name>A0A7W7WVG2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyisoprenoid-binding protein YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="182" mass="19029" checksum="5D21EC5D1554429B" modified="2021-06-02" version="1">MSTLTDQIPGYIAGTWVIDPVHSDVSFVVRHLGVSKVRGHFSAFEGTIVTGADPLTSTVTATIETASVDTRNGQRDAHVRGDDFLDADNHPELTFVSTGVRAVDGGFLVDGDLTLRGVTKTVTLELEPNGFGDGMQGGKVAGFSASTEINRRDFGVTGGPAGAVVGDKITILLEIEATLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS7</accession>
    <name>A0A7W7WVS7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA threonylcarbamoyl adenosine modification protein (Sua5/YciO/YrdC/YwlC family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="207" mass="22964" checksum="8A5CF1332D0F077F" modified="2021-06-02" version="1">MARYVDVHPENPQRRAIDQVVDLIKADGLVAYPTDSCYALGCRLDNKDGLERIRQIRKLDDRHHFTLMCRDFAQLGQFVHVDNAVFRAVKAATPGAYTFILPATREVPRRLSHPKKKTVGARITEHPVAQAILEGLGEPLLSTTLLLPDHAEPLVQGWEIKELLDNMVDAVLDSGECGTEPTTVVDFSSGEAEIVRVGAGDPSRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVU4</accession>
    <name>A0A7W7WVU4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="171" mass="18719" checksum="61527F894C24F3E0" modified="2021-06-02" version="1">MSVGPDRALLTVDVPGGPDVRAKLTQAVPRVLRSAFERCGLDRVWHRRRALPGVGDGFALGFHTRFLPDLVDPVLPALGDELDYRDDINVDPAPLRLHVSLDVGPPDPRTARRPPDERLFAPTVRLAAVLSARVVEIVRVSERLPGFGDAAYLWTPPGNPGARSRESTDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW45</accession>
    <name>A0A7W7WW45_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="117" mass="12233" checksum="4D5489232B67F6C0" modified="2021-06-02" version="1">MDIRESPLHVERSVRGRTVVVTVVGEVDANTAPPLHDGFGDALALVAPGGTLVVDLRDTTFFAAAGVTALVRLHKATGAAGVSLRLVATRRILRVLRISGTLVMFTPLSVPSPRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW68</accession>
    <name>A0A7W7WW68_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031032695" evidence="2">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="305" mass="32360" checksum="069B8EF250F8E55F" modified="2021-06-02" version="1">MSRSRSIRMTGALALAAAAALSFVPAGAATADPDPITSPTVVQNDFVVWRPSNGVWYRLANGAGTSVSWGVAGDVPVAGDYTGDARSDYTVWRPSNGTWYVKNRVNGTTSSTQWGIAGDVPQGADFHADGRDDYVVWRPSNGVWYVKNSANGATVSSQWGVAGDVPVAGDYTGDGRADYAVWRPSNGVWYVKNSATNATSSTQWGTAGDIPVTGDFSGDGVDDYVVYRPANGVWYVKDAVTSVTWTSQWGVAGDVPVSGDFTDDGYADYVVWRPSNGVWYVKNTVTSATSSTQWGVAGDVPVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH3</accession>
    <name>A0A7W7WWH3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030962924" evidence="1">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="14171" checksum="056AC530AA7290D6" modified="2021-06-02" version="1">MSLRRIIAGAAIGTALAVSTAVSPAQAATDAAAACGGAGTDRVGGSYVEVRSDCSVVGGPSTKVTYEVFGDRRFTNQRAVVEVYGIENGRPKWYSLGTVAPGPSVYKTVPWGNNAANPKIRITASAAGGALVAKISFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWH5</accession>
    <name>A0A7W7WWH5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8469" checksum="0747D021A327FBD6" modified="2021-06-02" version="1">MTDEELLVEFALTRLDHPGADLEDVAELVVRRLGEERMVEFASRTLAARDELRGALFPAAVEHVLRVVLTLRGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWV6</accession>
    <name>A0A7W7WWV6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5753 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5753" evidence="1">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="139" mass="15548" checksum="ABF7AF30EC6C8CD3" modified="2021-06-02" version="1">MVNLRMRRQEALDRVEPVLDVVAIIDEAVLRKEIGGPAVAVEQLDYLLILCERPNVSIRVLPNSAGAHPSLHGAFIVLDFPIERDPGVVCLEDRTGGRYRDDTDDIDEYTKVADRLSEPALSERESRSVITAVREEIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWW7</accession>
    <name>A0A7W7WWW7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030685356" evidence="1">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="146" mass="15783" checksum="65FD8A33C2F391CC" modified="2021-06-02" version="1">MARFTRTATIAALAAALVAPLFTAPAASATETAIGCTDGANPSSFPNPSSPRVVDGFFYGRIELRYSSNTCAWGRLTYHKSDLVWVDRANNITEANNGNWTQLGITELTTGHQVFTPGYNDNGKVMRACAELSDFNGLTVYCTGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX17</accession>
    <name>A0A7W7WX17_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="474" mass="51746" checksum="94AD24450F7F5D92" modified="2021-06-02" version="1">MSVTVGGSDWTSDGRTCAECGTPLEAGNSAQMCNRCHRASQDQLRTPPILKDQFFDTAEFRAASDSQHIGRIIKVYRHHPRHLKLYGRALSQELVGRWLGLTQAQISKVENAPRAEQNLEVLRRYAKTLHLPQSLLWFSLPPQGRYTERGVSTTGIDAAKLRQDLSEVLASTLISERGASDWDEAVFRLGRDTRWRPHATLASEILANLSELRVFYVRATSGHVLQRMARNTAQLSGLMSQTLLKVGDISGSADWSRTARQFASESNDLNLRAWVHAQEAYLHFYAGNMHTAIDAARYAQDIAGKSGGVGSALAAALEARAYANQGLRADALRAIGIAESLTAGLDGAATIASAFGYSEAQLRFHESNVLTKLGEFQRALVAQDHALRLTPHDDFMDRALVYFDRADSLIAQGDIVNGLAIAASTLGELETGKAAGLIVDRARLTLRMLPVSESGRVEALALHEIIAASNEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX61</accession>
    <name>A0A7W7WX61_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR system Cascade subunit CasC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010148">
        <property type="entry name" value="CRISPR-assoc_prot_CT1975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09344">
        <property type="entry name" value="Cas_CT1975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01869">
        <property type="entry name" value="casC_Cse4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="385" mass="41884" checksum="4EA495DC4F45FC16" modified="2021-06-02" version="1">MILELHLLQSFPVSNLNRDDTGQPKTATFGGRTRARVSSQSIKRAARLLFDEHGLDTSETGVRTKRLIERTVKVLAEAGRDAEAAPGVVTAALEHLGFGVDQEKLLTQYLLYVSREAVDKLADYSANHWDFLATQAQAKEAEKSAAEKGTKKKAQSAKSKPDKQTQAEAKRILDGTRAVDVALFGRMIADNKDFNVNAASQVAHALSTHVVRNEFDFYTAVDDLKPEDESGADMIGTVDFNSACYYRYANVDVEQLVKNLAGDTDLAARGLRAWLYSFIHAVPGGKQNSTAARTLPDTLLGVVRDRGAWNLANAFLKPVADDDLMAASTDRLTEHFAKLRAFYGDDRLRAVAAASVSGGIAHLDPADTVAGVEEFTTRLLTATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXA2</accession>
    <name>A0A7W7WXA2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="464" mass="50801" checksum="76D622D40545234A" modified="2021-06-02" version="1">MGRPAERVDNGTTIFHNGQATYRLSDGENRQERITVAINRLKAGMPRLAEEASAVDRVLDRLESLDEKTRLEIMLNVERIVGGVLQDALHVANARLVAGQRMEAGRERRAWKFFEPEPAAPRLLDWGVAEVPGMWQPAVAAVAALSGLVAMGIGHDLSTTWLALPLLVGGGWLVFGAAPERGLLDARMAKAGREHGVPAQPAPPASNEFRRLIRWHVRQVAGHWHRGDFFAYRPALTVPKNVTLRFGGGVTTATVGLVVLLCGGCAWFVARSVAPRAAAIARDEAQELHPAEQAEFERWRAVLAYHPEDVEMGRWLELDSAYFLDGVAHDEQLRSFRYEALASARVEEEGIRRAADGEDPGAGASAPFDRQRLRRRRFALSLVDCHPISALAETFQGPPDADAESQAELLCLAVGGSGIESAPHIRESVAAEGPGWIAREGTGGVVGRTRGDRPGRRRRKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYB0</accession>
    <name>A0A7W7WYB0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="277" mass="30235" checksum="6D8388446BF0AD66" modified="2021-06-02" version="1">MRADESEGIDVQAGVTRRVVGLRRKRAESAQLRGLVDDPDMVAVRIESQRRLITRGMWFFLTLGLGFTTAGVQDFLAGPRTAADPLWWAAWLAEPMLAGILITLLAFESEVLHRGVAVDSRWVERLKRTLLGSTLFMNVWPTLAPLWTPGVRFEFGNFAVHLVVPLVVFMVAEVMPVIQQRMNQAVTDAYRRAGTAPTPAPAPVPAASRPSPAASATGTRLRLPDPIRDAVKAKADQVAAQGRALTADDVRQAVRVPADLADRIVAEVHAHNGHSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYD4</accession>
    <name>A0A7W7WYD4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016499">
        <property type="entry name" value="NucleicA-bd_Rv2694c_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006910">
        <property type="entry name" value="NA_bind_Rv2694c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="125" mass="13829" checksum="2F8A014B9DCFF503" modified="2021-06-02" version="1">MTGSGGGYWRRLVRRLTTDVSELDADDLSRKAEEIGAVRACDCKSGEEVTVLGRLRTVELCPRDAAATLEAELYDGTEGVTLVWLGRRRIAGIEPGRTIKARGRIAVRDGRKVLYNPYYELQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYL5</accession>
    <name>A0A7W7WYL5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026487">
        <property type="entry name" value="CHP04141"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04141">
        <property type="entry name" value="TIGR04141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="434" mass="47443" checksum="9B1FF049AF86B6C2" modified="2021-06-02" version="1">MARIEDPTRPTTLHRLHAGRGLADYLVDDDHVLVVFAGPVTLDGVEAYRVEGVLDDDRTRPSAVVVLVRVDDRVFAATWGHGVRLLDGTAIDHRSPGVEPHVVRLLTRVVGTASTGRADRFFADLREVLRTMTDEHPPLRRLVGGPLDLADDDPVRLLLEDRLADALGGGGTDRVDVRWPSGARPYADRTRSFRSNDIGGYGPLRVDGPLAVDHVVDRFALLCKGTRVGELRQARLIPCADADAQALFTGPIALDRWIAFETRVDGDRYCLHQGHWYRLDADTAADLRSRVEDLLRRRRDLGLPDWAPTDDEERYRDRVAARTPGFTTVEPVGLVGPDDELVHVARPTPDVFDRARAAMWDLRLGHRVGAEPRCRTATVVLAVPGGLPVADLPAATMADLLELGADLEVLGVALRFADIPLAGRPGAKPTAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV3</accession>
    <name>A0A7W7WYV3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,6-dimethylbenzimidazole synthase</fullName>
            <ecNumber evidence="2">1.13.11.79</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.79" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102919">
        <property type="term" value="F:5,6-dimethylbenzimidazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="210" mass="23302" checksum="8719FE2D9E65F3F1" modified="2021-06-02" version="1">MNFYDVLHRRRDTRAEFTGAPVDADVLRRVLTAAHAAPSVGLTQPWDFIVVRGQETRRAFRDHVLAERSVFAAGLDDDLAGVFKRIKVEGILEATLGVVVTYDPRRGAPAVLGRHAIADAGLYSVCLAIQNLWLAATAEGLGVGWVSFYREDALRRLLDIPSGVRPVAWLCVGPVAALPDTPDLERHGWRTRMPLDDVLHEERYTPRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYY4</accession>
    <name>A0A7W7WYY4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031038332" evidence="2">
        <location>
            <begin position="27"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="197" mass="19636" checksum="6741DB36F647F480" modified="2021-06-02" version="1">MRSRLVATLAVAAVLTACTGGGGGTAQSTSAKPDDSAAVAYMGKVCSAASAFVDAPKTPPGLAGDDPAKLKADMARYMGQMADAFTKSATALREVGPSPVGAGDSEVAAMATTFTDIAAAFADAKTKIEAADAGDPTGGLQAAGDAIAKMDEFVVPLRELDATPELKGAAEKAESCQKLRRVGRSEQPSPSAAAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ72</accession>
    <name>A0A7W7WZ72_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsW (Lipid II flippase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="488" mass="51839" checksum="A7F105117FD658C3" modified="2021-06-02" version="1">MGSPVTGADGTPLATANSTSPGFRPSTKRNTAELFMLAFASIIVTGALILVEANQEQELTMGIVWLGLSFMGVMTVAHLAVRRWAPNADPVLLPCVGLLNGLGLVMIHRIDLAMEDVKFPNGTTWSDAAPKQVAWTAISLLLFCVALKFLSDHRTLARYGYTFGFLGLIALVLPGVLPSFIAPEINGAKIWLSFGAFSIQPGEFAKILLMVFFASFLVQKRELFTAAGRRVLGLDLPRARDLGPLVAAWAVGVSIMVLQKDLGSSLLFFGIVLVLLYVATERAAWVVLGLTMFCVGAFAGWKVFSHVQVRVQNWLDPFADPSGSGYQIVQSLFGLGTGGLFGAGLGGGRPDQIPEANTDFIAAVIGEELGFVGLAAVLLVYMVFAMRGLRAALSVRDTFGKLLGGGLAFAVAFQLFIIVGGVTKLIPMTGITAPFLSKGGSSLLANYVLVALLLRISDAARAPKAAPAPRPQQPAIADQFTVMVERPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB4</accession>
    <name>A0A7W7WZB4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="34856" checksum="4D7FCFD60BEBA842" modified="2021-06-02" version="1">MTAAPDADFESARAEAEAAAKPERTRKQTIIAWARRVLVTVVLLGAGYQLYAQWDDVSATLLALPWQSVVLSLGAVFVGLFLGSVVWKIVLSDVGAPVSYADAAKFYLVGGLGKYLPGAVWAVLLSMELAKQAGVNRARSFTAGLVATGMGVVASLITGLAALPVLLGDSEHQELLWLFSLLLVGLVFLHPKLLTWLVNLVLKVLRKAPLEQRFTGKEVLKATGVAVLIYVLYGVHLWLLVNSLGSPDLGTLVLCAGTMGLSMTAGLLAFFLPSGLGARELVITAAIATVLPSGQAVALALVSRLMFTVADLASAGIAALVARLQRGKTIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZB8</accession>
    <name>A0A7W7WZB8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9106" checksum="34891438250FB0FD" modified="2021-06-02" version="1">MRYTVRLRSGDFTKAATLAGLRSDYARSKAMGVNRSTVTRVLAGELRPGAAFIAGALAALHPMDFKDLFEVIEHGPARGTTQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZK9</accession>
    <name>A0A7W7WZK9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator YbjK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="194" mass="21145" checksum="4D1D22B82FDA1678" modified="2021-06-02" version="1">MTAATPKGERRRQALVEAAAGLLVDGGFDAVRHRAVAERAGLPLASTTYYFSSLDELVVAALEFHGNVEYENGKARLAALDGVEGDAAFTDLVLDLLLGPPTEEGDAEQVLLRYERLVATGRRPYLRPLMRRLSGQLHALLLEIFLASGRTWTAERVEEIIALVDGAVVNALIEISPDPRAAARRMLDKAMQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXF8</accession>
    <name>A0A7W7SXF8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_000022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030858969" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="34"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="46"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4962663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="375" mass="38191" checksum="3ED9A8F2C0AC67AB" modified="2021-06-02" version="1">MKTTRHGAVLGLIAAGALLLTACGSDNNTPAGNATSATSGAAAATPVECGGKAKLNAEGSSAQKNAIDTFIQAYKAKCSGQDLAYNASGSGAGVKNFNAGQVDFGGSDSPLSKDKGEVEAATKRCQSNPAWHLPLVFGPVAIGYKLEGVKDLVVNGDVAAKIFNGTIKKWNDPAIKALNGSATLPDKDIKVVYRSDESGTTDNFQKYLKAASKGAWTQGDGKQFKGGVGEGKEKSAGVAQAVGSVDGAVTYVELSFAQDNKLSIAKIDAGQGAVELTGESVGKSIEGAKIKGEGNDLVLDLDSIYATTTAGAYPLVLATYEIVCSKGYDPDVAKAVRAFLTVAATDGQAGLADAGYAPVPKAFQDKLLTAIKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXK2</accession>
    <name>A0A7W7SXK2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_000158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031144178" description="Aminopeptidase N" evidence="11">
        <location>
            <begin position="27"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="50"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="309"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4962799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="496" mass="54027" checksum="0609EA42267A2862" modified="2021-06-02" version="1">MSLRAKLTIGTATAASLLLLAGTASAATPGAPGIGDPYYPNAGNGGYDVSHYDVRLNYRPSDDNLSGTTTITAKATQDLTGFNLDFVLNVSSVRVNNRVASFKTEKGELVVDPKATLRKGADLTIVVTYSDAPSKRSVDGYTAWRRTADGALAIDEPDAAPWWYPSNNHPTDKATFDVSVSVPDGLEVVSNGTFAGTVKQINGWTRWRWRSVKPQATYLTFVAIGQFEVRHQVAPNGQPFVTAYSLSSDSADDEAAKASVERTPEIVEFLEGSFGPYPFEAQGGVVTPGINFALENQTRSTYGTAFFRRGANTYVVAHENAHQWWGDSVSVHAWRNIWLNEGFASYAEFLWSEYIGEGTAQENAQFTYDLYPADSPFWQVLPGDPGADKQFDGAVYDRGALAVHALRVAVGDQHFFEILKTWLAKKKYGDATIEEFVAHAEKISGKPLVELFQTWLFTKGKPAAAPGGQVGIAAKSVAKPKSFDQIRETHRILSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY81</accession>
    <name>A0A7W7SY81_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LCP family protein required for cell wall assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_000507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="84"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="3">
        <location>
            <begin position="360"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="477" mass="50101" checksum="7D8A1D9997190FE3" modified="2021-06-02" version="1">MSVAVLVVTGYGWRYIGQLDEGITTTDVIVAQAEEQQGHTRKPLDGAIDILLVGVDSRTDAQGNPLSEEVLALLNGGKADGTLNTDTMILVHIPQDGTRAVAISFPRDSYVEIADGFGKHKLNSAMVRQRTDTATRLREEGVTDQARIDRESLQAGRKTLIKTIEELTGGLIVIDRYAEVNLASFYEVTKAVGGVEVCLKEATQDSDSGADFPAGRQTIEGRSALSFVRQRNNLPGGDLDRIVRQQVFIGALASKVLSTGTLTDLGKLDDLVSAVKKSVVLSDRWNITEFAEQMSGLVSGNIQFRTIPTGDPYDVWEDGNVLPVDPAQVKNMVRNLAVDPPKTTAAGPTTTAAGPDNSTITVEVVNSAGMPGAAATVLSALVSQGFRDGGARSGPQLATSAVRYPPGERANADKVISALGGNTEAREDDSVPRGQVRVVLGGDHSPADPAPVAGTGVGLPTTDAAPPITAEGVVCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYA3</accession>
    <name>A0A7W7SYA3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_000487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040868">
        <property type="entry name" value="DraK_HK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18092">
        <property type="entry name" value="DraK_HK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="148"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="208"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4963128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="44814" checksum="3D2FF6132A196558" modified="2021-06-02" version="1">MRSRILRAILLAVAVTGFALGIPLGYAALRLVEDNAHNELTTRTQRIAALLDDQIANGRAIDLTPAAIGVPEGGHLVVTTPAGRHEIGRSPGLDALSVEMPLVQQGTVRLEQPSTPMRTDQYKVAALVVLLIGFSVGTGTVVATVTARKLARPLRHVAARAARLGAGDFRDDLRRHGVPELDLVAEALDRSAVALAQLVQRERDLVGDVSHQLRSRLTALQLRLEELAEHPETASEAQAALEQAERLAEVLDEMLAAARAARAVDAEPLDLQGELTAIAEEWREPLRRVGRSLRVRVPEGLLARATPARLREAIGVLLDNALRHGEGQVVVSARRDEGTVVVEVADAGSGVPDELAGHIFERGVSGGGSTGVGLALARALVDADGGRLELSAARPATFAVFLPIPKAEDVVGVTWKAEPTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYJ0</accession>
    <name>A0A7W7SYJ0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="81" mass="9029" checksum="8425663DCFAAE1CB" modified="2021-06-02" version="1">MVDKIEGHNVRDPHDLHGKVEVQLDQAAEELTRRLDGNVDYQVARTAVSAAYRRLADQARVHNFLPILAARAAFQSLTHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYP9</accession>
    <name>A0A7W7SYP9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (TIGR03089 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="230" mass="23768" checksum="F838B2FE04BBFC66" modified="2021-06-02" version="1">MTVTERLFLPLLSDPGRPVITHYDDAVGSRVELSVATLANWAAKTANWLRDEHDVEPGDPVAVLMPAHWQTAGVLLGAWWAGAVVTDVPRDVKVAVVGPGIAAPGADVTAVASLHPMGLGGGNPVDYLDDVRLHGDHFTPYAAIPGTALALGSSTVDEVVAEAGQRATTLGITSASRVLSTVEWAFPDGVLNGFLAVLAGGGSLVQVGNADPGRQAARRTSERTTLDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ5</accession>
    <name>A0A7W7SYZ5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="31529" checksum="0FF4D8A5E3491DDF" modified="2021-06-02" version="1">MTSGPEADMTSGKKTKAARSSVAAARSSVVASKPKPWGTIVAVIAVLALAGGVFGYAITQLNEKSDREAALAKWNPTEENKDPSDQIQGVVKKTYEAGKHVQPTQRVGYDLSPPYGGPHDSTWANCMGVVYAKPVRTENMVHSLEHGAVWIAYNPDQVTGEALDKLKKKVEGRQFSMLSPYPGLDKPISLQSWGHQLKVDSVDDERIDQFVQSLLRNQYQYPEIGAACDSSTFDTENPPPFVAEKPGADAIPMEGGEKDATEAGGEMTGTVAPTAAPTAGTGAPATQGSAAPTTQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ04</accession>
    <name>A0A7W7SZ04_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="594" mass="64928" checksum="5349CD692D553B6A" modified="2021-06-02" version="1">MTDDIGSGNRRLLDLVTRRQRAVLDDPTAFFPWRRPCTVKTLLVTDGILDFGLGDFGLRTFVDVLINDKRSYVRFDLTVAHLSATVSNAAVLQGVPGISRSIKGFVFDDPDHFTPETYDVVWLFGFDSFIHGVDYPNRTADPARYPATRLGDAELDALTAHANRGGGLFGTGDHGSIGSALCGSVDRLRGQRHWQDFGASEVGMTTARRNDSNRIGHDAGSQFSDQSDDVPQVLDLKLYSTRVGLLKAARYPHPVLCSRLGRIDVFPDHPHEGQVRVPPNLGLSCRDGSPEYPDAAGGGQVVPEIVATGRVPAGNTASSNGGLNLKTPTIAHTFGVVATYDGHRAGVGRVVTDSTWHHFVNVNLIGVVEGGLFDDFVGPGPGPGTPGTHFSKHIGFLASPSGRAALDKIREYYVNVGVWLAPPARIKCMNSRFWWELLWSDRIVEATLQRPDLTLDKVALPELFHIGVHARDVLGRHAGACRTLHWVFPLIVDLQVELRPWIDPWWPGDDRREVDPPLPWLDVQPLVDVAVGGALVALRGAFPHPGTDVDFDDKAREVALKGARTAYERGLERFRGDLKGALRFTLPGEETGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T087</accession>
    <name>A0A7W7T087_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031061779" evidence="1">
        <location>
            <begin position="30"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="34695" checksum="DD17EF0DC8D186EF" modified="2021-06-02" version="1">MPRLVAVLCALLVLAGCAGTDLSKQPPSARSTIPAKDAADAVATSTGAAPTGTAGEGPVDPAFAVDKLRLIDPCALLERDLLAQLGTPGETSRSGFSRCSNFMKDKNKKDLAVTVDVGQSLTAELNNAKKQLAGLKSHEQVLPGSACFVSVITQEKPGLGITVQIGSKEDEPCAPGRVVAEAVVKKLKTKPSPVTPAKGSLLTLDACSLPDKAAVTAAAGTQARTYPYGLHTCSWLGDSEEAGLDFRLGFVPRDKKFDPKQTEVDLGNGVVGYQVDGSTAFPTCTIKWVQRLASGDEGETVEVKSAGPSKATFNRCERAQALAKAVLPKIPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0I7</accession>
    <name>A0A7W7T0I7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="241" mass="26993" checksum="B4429B0EAB7D272E" modified="2021-06-02" version="1">MTDTPEGRGELVALAHRIVEEAPLPRTRWRLRATLADGVTVLAAWHQQELVETGQAGVVGTERLDWVQAAAPHLTEENHNDDPDHPYVYGTRRWEYGFDLSDPDQVLDALVTVVARARLDQALHEREREAEQRARAEAHADSLALLRAEADRVASSYARPDRTGLLEAFAARRYAVRRVRTLEPCPLTVEQIAEVAGMTVEEVRQQQPLVLTMTSPARTSLRNDGHITDEVTAESLWGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0P2</accession>
    <name>A0A7W7T0P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="187" mass="20504" checksum="EE70B1685814C06D" modified="2021-06-02" version="1">MAEPDLVADLRSADPDRIAAALAALDHAERTRRFLVVPPPEPAALDAFDTVPEQVLLHFVALWLEYPAFQPAPDIADVHRTIVDAVLRHGGPTALHRVALGLRTCERPAVAARDLVRDLHDRDLTDAEQDRASVLLDDLLDVASTHRAVADGVVYMALFGAHTRLVDTVRRRLGPEDRARVDAARAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0T7</accession>
    <name>A0A7W7T0T7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6863" checksum="A6422101821B9459" modified="2021-06-02" version="1">MNLTGSVRQSCYIKIYGDAPMKVRTSPDEIEIGYDGDLDLVLTHLAATKLHDHLVEYLASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1H9</accession>
    <name>A0A7W7T1H9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)mycothiol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.306</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_002199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.306" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050607">
        <property type="term" value="F:mycothiol-dependent formaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017816">
        <property type="entry name" value="MycoS_dep_FDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03451">
        <property type="entry name" value="mycoS_dep_FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="37641" checksum="1167600127052534" modified="2021-06-02" version="1">MTQRVRAVVARGRGAAVGVETILVPDPGPGEAVVRVQACGVCHTDLHYREGGIDDGFPFLLGHEAAGVVERVGDGVVDLEPGDFVILNWRAVCGTCRACRRGRPWYCFATHNAKRRMTLEDGTELSPALGIGAFAEKTLVHAGQCTKVDPRAEPAVAGLLGCGVMAGLGAAVNTGDVGRGDTVAVIGCGGVGGAAIMGARLAGAARIIAVDIDARKLETATVLGATHTVDAKTTDAVEAIRGLTDGFGADVVIDAVGRPETFKQAFEARDLAGTAVLVGVPTPDMKLELPLIDVFSRGGAVKSSWYGDCLPSRDFPLLIDLYLQGRLDLAAFVTETIPLDGVEDAFARMERGEVLRSVVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P3</accession>
    <name>A0A7W7T1P3_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23094" checksum="B6B0B01945B901ED" modified="2021-06-02" version="1">MTVSFLIRVQLPDRPGTLGAVATALGEIGADILSVDVVERGPGLAIDDLVVELPSGRLPDVLITAAESVEGVEVDAVRPYAGVLNTHRELELVEDVAEEPARGLAVFTEGVPRIIRAGWAVVFAADGTGVHRLTASSAAPETRIENPPWFPLARATVLDGEDTWVPDTWRELGTELAATPLGKPDRVLLVGRPGGPMFRAAEVARLAHLAGIVSVVLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1U6</accession>
    <name>A0A7W7T1U6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031373626" evidence="1">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="25588" checksum="CCDFF3FB29331CB5" modified="2021-06-02" version="1">MYRIAFALVLVLGSLVGCTARTPLPAPTPGEVFEDAPPLVVSLSERAQAQSSVRFTTETTMSGRTVRLEGGLLRAREGRLVALREDSVIDVVSLADKGFARTSGAAWTRHATDDRVPGRTGMAFADVADTVDPVAVVESLGGSLLVASEADTVNGVATHRYTVLVDLRQQAGNVTDPEARARLNAAYASGFTASATVWVGPGDLPVKVEQVLKTLEDKDFRRTVHTFTDWNADIRVVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T296</accession>
    <name>A0A7W7T296_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-dimethylarginine dimethylaminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidinotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015067">
        <property type="term" value="F:amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="PTHR10488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="40561" checksum="99ACF43FEECF473A" modified="2021-06-02" version="1">MTVGQLVTGHDGAATRPAVHSWDEFTALHEVVVGDATGAHLPDLVRDRSAWLNYYPDLDASSLREVHSGLMPRWIVDETNEDLAGLVEVLEQFGVTVRRPAVVDHAAGFGTPEWSTTGFSCYCPRDLTLVVGSTLIETPSPARSRYFEQFGLRPLFQDYLRQGATWLAAPRPRLADELFPLDADGLPYLGEAEAAFEAANVLRLGRDVLYQVSRSGNEAGLRWLESTLRLLGDVRVHPLRDVYGYTHIDSTIAFLRPGLVLLNPSRITPAEIPAPLAGWDVVWCPPVEDRPMAAAHGLSGPWISMNLLMLDERHAVVDADQPALLRALERHGITVVPHRLRHQRVLGGGFHCVTLDVVRAGGPENYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C8</accession>
    <name>A0A7W7T2C8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="379" mass="38800" checksum="70E60133B7CD42EB" modified="2021-06-02" version="1">MRTRWLESASAEVAPSAVVDFSVRRAAGGLFAAAGVQAAVCVAVTWSAYPSWFRFGVLPVVAAVFALGCARLVTDRTPSSWVARLCGLGAGFSVAASVGVAGVDTGGTNVAEPLVGLGVFGAGLASARTAAVVLIAAHRSGLALAGTGGLGEQLGLGLLEVASFTAAVVGGGRLRRWAATYDGPAAALAAAVRQDAEWERVDVARREHARLSHDEPLFTIRLIAEGVVVDSPGTRARCRREAAILRGRLPTVAEPDLTRDLAVKAEQVRGLGLEVVVDHEGVPVPLRADVTSAVVGATGAALRNVVRHGGVAVAGVRVTWSPGGVRVVITDRGRGFDSTRPGGFGVPEAIGRRMRQVGGTATVHSVPGRGTEVTVAWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2G3</accession>
    <name>A0A7W7T2G3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="69" mass="7064" checksum="7D342FC674A7629E" modified="2021-06-02" version="1">MSTLNPALRRDGHPTNRPGPTGLPVGVPSTSGTRSSDWSAHRPDTPRPPAGGGSDSAGTVAGRPRPRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N6</accession>
    <name>A0A7W7T3N6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031463325" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="157"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="445" mass="47539" checksum="D479B24CAF0562CC" modified="2021-06-02" version="1">MALRDGVTVLAAVAALAGGGVAASAPGADRVVAVDYPALYADAAEAVRQAVADTRFRDVLDLTPPSGAGPAPLHRTPNLDVAVIALDDAARPVAALDVLLSGDHPEGVVVPVDPATLSNGRVRYRWWDDAEWDADGRGDRDVLPGREGTPFDFTSPYPASVLKLMVAFGVLRLVDAGVVAFDTRYRYLPAEESSMCGGERTATVRRYLDEMITMSRNQSTCALLKLLHDRDAVDGLNRTFAGLGLTTLMITGTDPGTGGHWMGSNMGALDTAKLLVLVAGGPDVLWTTEAGVPVTADVLSPASREFLRGRLAEQGHNEMLSTTNWCGLLAPGIPQRTPPRWVNPLTGRVTVGDARYDRDVRPCDAAAEVTFAHKTGWTDTTGADAGIVRSLPGKPRRHYVVAVFGNLGTDYVDPDRPADRPDVFPVLYTRKYAELGRAVDTIMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3N7</accession>
    <name>A0A7W7T3N7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="43" mass="4722" checksum="E71445A482A9E5C8" modified="2021-06-02" version="1">MKLLCAWDVRAIRHGDVGVSMRIGLPGVTTAVCELDHMSIQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3V8</accession>
    <name>A0A7W7T3V8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide/nickel transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_003412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4966053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="273" mass="28710" checksum="6B09F9C998E34DD1" modified="2021-06-02" version="1">MSVAVEPFLRTTRVRPTVVVSFTILAFVLAWSVAPGLFTGQDPAAGVPAEKFLPPGGAHWFGTDHLGRDVFARVVHGTASSVTSALIAVGIGVLVGGLLGLLGGFLGGWVDAVLARFVDVLLAIPSFLLAVVVVSALGFETVNAAIATGVSAVGVFARVLRSEVLKIRRAVFVEASYLQGGSRWHILVRHVLPNASRSVLTLAVLQFGLSILVIAGLAFLGYGDPPPASDWGLLISVGKDYPLAPWLVYAPALVTIATVLSVNRISRWLRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3W5</accession>
    <name>A0A7W7T3W5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="161"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="271" mass="28436" checksum="D0E656B96AC1DF61" modified="2021-06-02" version="1">MSVTVSVAELRESTGVRLLDVRWRLGVPDGRPAYREGHLPGAVYVDLESTLAAHGGPGDGRHPLPDRAALQDAVRSWGLADGDPVVVYDDWDNLAAGRAWWVLRNAGIENVRLLDGGLAAWKAAGLPLESGDVTPEPGTATLVEGRLPTIDIDQAATWPGVLLDARAGERYRGEVEPIDPKAGHIPGAVNAPTGGNLAEDGTFLGAEALRARFAELGVKAGDQVAVYCGSGVTAAHTIAALRIAGIDAALYPGSWSQWSNHPDRPVATGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Y7</accession>
    <name>A0A7W7T3Y7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="249" mass="26047" checksum="93D81BC2D306E335" modified="2021-06-02" version="1">MDEQQLTDGLRLLADEARPHPLDVDRVVERARARGRGRVATIAAGVVTTALVGSLVLALNGFESAGGPPAGQLGVAVPGRDARSARLDTEFAATRSALAEAGLVTDDSFAAAAPFHRWYDSVTGTSYVMRTILRDGTGMATLEISVGKVATDKPFTAFTGPSAGTLEPCTSDQPGCVRRTLPDGTIAAAWPNSRPVEGWGPSSVLCAQRPNGTYIVVVANVGAEYLDPPRPVPPLDAAQLLEFATAFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Z0</accession>
    <name>A0A7W7T3Z0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding SARP family transcriptional activator/DNA polymerase III delta prime subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4965891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1055" mass="112500" checksum="33A4383FF7DAB395" modified="2021-06-02" version="1">MEFLLLGSLEVRSAGAPVPVASGKQRVVLATLLLRANEVVTVDELIDRLWDEDVPAAARGTAQAYVMRLRKVLGEGVIGTVDRGYVLTVDPDRLDLTRFRAALRRADEAAAAADRVAEAACLGAALDLWRGRPLSNVPSDLMHREEVPWLEELRLHAVERRVQLDVDGGAHNRAVAELRSLIAEHPLRERFWAQLMLALFRAGRQADALAAHRALTARLAEELGIDPGDEVRRLHLAILADDPALLGDRDTAPPQRGNLPPAAAHFVGRTAETVRAAGLLRPLPDRSSPRYVVLSGPPGVGKTALAVHVAHAVREDFPDGVLHVDLRGFSQQPPLTVQRALTRLLRGLGLNAEQVPLDEDAQQDRYASLLTGRRMLVVLDNAVSSDQVRPLLPGEPGCAALVTSRNDLRGLIALEGARRLALDSLPAADARRLLVDIVGTDIADAEPDAVAELVELCARLPLAVRIAGANLVGRAGAGVADHVAELRRANRLSALAVDDDEQAAVRTAFGLSYETLKPDERRMFRLLGLVPGTDFTPEAAAALADEHEATAATLLGRLVTANLVQQQGNRRHQLHDLLRLYARERAELEDPAEHRALALDRLYRHYLRWADAAAVVLNPASPRLPRPEAAAPAAFDGPARAVAWLSAERANLVGAVEFATAHPDLRPWSRHLADAVTGYLHTHRHDSDLLAVATAALDTARADGDRPAEATMLRALGVLDWSLGDYRRALERLRAALVLHREVGDAAGAGTALIALGVVHLEDGRLAEAARHFAEAAEAEVPAVAVAALARLGVARLEAGDLTAARAHLESALSSAGPLGLVHTEAVALNTLGAVHLRQGAFDEAIASHQGALERYQVLGSRHDQAEVLQNLAAVHRDARRFATAVEYGEKALALARSTGNLRFAADTLNTLASARAGQLDWDAAVRGHSEALGLSRRVGYRQGEITSLIGLAATAVGLGRAAAAIDDAGRAALLARTTGFRLREAQALTVLAHAEVDAGRPEDAAAHAAEALALHQASGNRLGIARAHQVLELVAGSRDPDRPEEAGATTGKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T427</accession>
    <name>A0A7W7T427_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="51" mass="5619" checksum="E57CD14E04351B8D" modified="2021-06-02" version="1">MITRSGLPSCVATAAACRNPDFAFSTCPYREAGAYNPTSRRIRPPAPMWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4M9</accession>
    <name>A0A7W7T4M9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein assembly factor BamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="513" mass="55548" checksum="5CD163B818982242" modified="2021-06-02" version="1">MDEVRYDVALSYASADRAVAEEIAGRLTALGHRVFYDQARQAELWGTELPVVLERIYGRESRYCVVLVSRHYVESVWAREEFRSALAGALFGPDRADSVLPLRLDDTALPGLRPTVAYLDHRRLGTDAVVRLLLEKLGTSVEAAAHRFPRRRVLGYGLGLVAAAGGVYAAGRWSSTGPGTQRWHRHFTSACNPLVDSGNVYLALDDGSVVALNAADGAQRWRADMKGEMVLRCSVVEGLVLVAVTAGQDRGRLTALDADGEVRWTLDTEGWPWTQCPARDGRVYLGTASGWLYAVDRLTGKPGHAARLTAQVDEIAVALDAVYVATLTDGVLVLAESGEARWSRPAPTAVPGLAVDDDRLHYTVGGDPRAGKGGQVRTVGARDGEPLWTHDFDTLIQVGPTVARGRLLVPDLRGTLHCLEASTGKVLWQQDVDADLTNRVTVDGDVLYVGTRRGLAVLGLDTGEIRWSRDIVTTPPNDRYSAARPVLDDDSVYLGYGDATTSSGDGDVYAFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4T8</accession>
    <name>A0A7W7T4T8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031122334" evidence="1">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="124" mass="12356" checksum="DACD7C24CA20F375" modified="2021-06-02" version="1">MRATIVVIAAFAAITTLGACGSIAETASSVANTATTVQVCADALSQVSIPLDVSSPQRAVDQAHQAATELSALAAKAADTTINEAIAALARTMTSVTVDDLVGRPAQWLADQAGQVATLTGACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4Z4</accession>
    <name>A0A7W7T4Z4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding protein with PD1-like motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15845" checksum="E4300943ADC0B87C" modified="2021-06-02" version="1">MFDHQDDFFPALDDFCRHNNVRHAFVPGFIAGFSQADLVATCTPPDDPHAPVWDSIRLDHVEALGSGTLAYDQTTDSVHPHIHVAVGRKHHNATGHTSHLLAAHVQFLTEMLIVEVTDPELHRRRNPDLYDVPQLHFHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5E2</accession>
    <name>A0A7W7T5E2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031189016" evidence="3">
        <location>
            <begin position="46"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="744" mass="76848" checksum="0958EF0DD079957B" modified="2021-06-02" version="1">MLAPPTASTRRTRRIGRLLRVTRSRALVALAVSLVVLVGGTLASAALSPDSGTRVVPAAAAQPAPPTDLPPLPLPTVDPDPCGPGSPSLPICTLPTPTTTPPMTGLPLPTEVPTLPPCDPAIPLQQCAPTGTTTPPTPCSGEGCIPQPGTTTAPPTNPGTGQPGQGEEPEDDCGITDIGACITEAINAFFRGIVTEALNPLLDLLSKTLLTTPMPDSLPRVGELWDNSWQILLISYGLLVLIAGVIAMGYQTVQTRHSIKELAPRLVVGFLAGALSLWVATKGIQIANALVAAIMGGGVDANSAGETLRNLVLGSLNGGIWIIFIGIFLAGMLVALLITYVVRVALTIILIAGAPLALMFHALPQTEGIAYWWWKAYGGCLGIQLGQSLTLITAMKVFLAPGGFTIFGPTMSGLVNLLVALALMYILFKIPFWVLSSVRGGGGGRGLIGSLVRAFVAYKTFGLLGGGGAKSPKPRPSGGGRGGNGGGSSSGGSGSSNPYANAQTTANGQYVLPLPGVRRTRPTGKPAPKPKPGPASKSSGPQGRQLALPLGDDWPENKPVLGRDGQYRLPLDVQRTTPPPASPTGTDTGGRRTRAAGGKQLELPLDPYRGNRPNRSGQYPLPLDGVRRVPRPASPPPPPSPHPSGRRVVQPELPFDPYKGNRATRGGQYPLPVDGVRRTPAPKPAPAPPPPASPRPSPRTGQQLRLPLDLPKPAKPPTTPVFSSPPSPPAPPAPPSPKPGGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5H3</accession>
    <name>A0A7W7T5H3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10681" checksum="3FB2053C7CEB1651" modified="2021-06-02" version="1">MAHVPELVEKVRSAPLEDAGFAETVAAFAAALWRTVRERPAGHRLLKELVMFALRSPQLRDTPAVHYVDIAEVTAGLVAEAAARTGHEPARPPCRTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T601</accession>
    <name>A0A7W7T601_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030758604" evidence="1">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="105" mass="11476" checksum="A02320511E2975F7" modified="2021-06-02" version="1">MIRVLLLALVLVAGCSAGAAPPAGDLDLDLFADKPTPRRVELRKDSKVKLTVHSDKPVDVHVHGFDKLAEADRDRPARLEFTADRTGTFDVEAHPETLLAQLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T668</accession>
    <name>A0A7W7T668_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PPA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="PTHR22953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031015775" description="Metallophos domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="213"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="461" mass="48299" checksum="36B1D602EE7D4C0B" modified="2021-06-02" version="1">MSRRSVAVLAAGVVTAATFVVVASQYSASAASTTFPATADTYVDSGSTSTNFGTASSLGVDGSPTKRTFLKFAVTGVSGTVTSAKLRVHTDDVSGASSPAGGTFRLTTNTTWTESGVTYANQPAIDGATLGSLGSVSRNTWYEIDVTSQVTANGTYSVAITSSNSDGSDYDSRETGTTAPQLVVTTGTTPTTTTTTQQPGGDPVFVGAGDIANSGSGDSATAALLDGIAGTVWTTGDNVYDNGTTSEFNNYYDPTWGRHKARTRPSPGNHDYNTSGATGYYSYFGAQAGPSGQGYYSFDLGNWHIVSLNSNISMSAGSAQEQWLRNDLAASTKPCTAAYWHHPLYTSGSNHAPSTSTRPLYQALYDYNADVILFGHNHQYERFAPQDANGNLDNTRGIRSFVAGMGGASHYGFGTIKPNSEARNSDTYGVLKLTLHSNSFDWQFVPEAGKSYSDSGTTACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T695</accession>
    <name>A0A7W7T695_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <ecNumber evidence="8">2.5.1.-</ecNumber>
            <ecNumber evidence="8">2.5.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="8"/>
    <dbReference type="EC" id="2.5.1.74" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="340" mass="35277" checksum="8772D9A8903D0697" modified="2021-06-02" version="1">MAGRIAAFVRLSRPRFLVESQLTVTVGVGAAVSAGHGFAFGTWLLVQATVALTHLMTHYCNEYFDLAADRAHTAPNRWTGGSQVLVSGALRPEVSLSAAFVLLFVVLGLTVAMPTPAQRLIALAAIAVAWFYTAPPVKLNHRGLGEIATAASLAVFCPVLTGVSLTGGVPASLVAVAIPLMLVMTARMTVMNFCDRESDLVAGKRTLPNTLGARRAALLFAGLQAAAYTSVLVTTLVGVLPLAVGVGLLITAPGGYVLAVRLRRDPPSPDAPDRATATAHLATTHAAATGIVAVLGFVVAAAVEHGFTPSVWACVVLFALYVVPASGVQVLDALRRRRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6B5</accession>
    <name>A0A7W7T6B5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="32305" checksum="3DE774C05E583A40" modified="2021-06-02" version="1">MSSTPDKRRVEFADELRFLRIGAGLNGKEFADRLGWHPSKVSKIENNRQDPTDADVAAWLDAVEAPAPVATRMRDELRGMRIETNSWKNRLRKGHGDRQRYSVEVEGAATRIRAFELMVVPGLVQIAEYARHVFVTAAELQETPPDTDEAVRIRLERQRVLYDSTKSIELLMCESALRYFVCPPDVMLAQIDRLLALIGLAAVRFGIIPLDTVLPSVPTNGFWIVGHRVLVETVDSEIDTDSPVDLATYHKLADSLWTVAAEGDDARRVLMRCAAAIAEKYDLNHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6F0</accession>
    <name>A0A7W7T6F0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="62" mass="6782" checksum="F7DDA02A46E752FF" modified="2021-06-02" version="1">MRTQAEALWTVVEARWEKLRRQPEAGYSTETVLVTALLVVAALAVIAIVIAKVTEKANGITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6F6</accession>
    <name>A0A7W7T6F6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005769">
        <property type="entry name" value="PhnE/PtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01097">
        <property type="entry name" value="PhnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="28844" checksum="3C2697257763F2F8" modified="2021-06-02" version="1">MITVDRLPVPPKPKRPKAVLFGWLIAAAVVAAHVIAWDATDVSFGALVEGWEGMADFLGEAIPPDLSWKVLGPSLSGALVTLWIGLLGTALSIPLSLLPALAAAKGTAPSAWVYQASRAVLSFLRAVPDVVFALIFVTAVGLGPFPGVLALVCHNVGVMGKLWAEALEDADPGPPQALRSAGAGRIQVAVHALFPSVLPQLAGLLMYRFDVNVRSSLVLGLVGAGGIGFLINQSIKLFKFDEMLTHILVVVVLVVAVDRLSATVRARLSREETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6H2</accession>
    <name>A0A7W7T6H2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="26122" checksum="B3FCD3F6C6D0D5B3" modified="2021-06-02" version="1">MTSPSVSVTPGSTLFAVIPRGPSSLAGVVDSASTAAFVAVYTPMPGAGDLVSRVELFTIRPRSGRRAAAWRRTRRTALRLRSTKRSKSSAAKSAIGPVHGDSGVVDHEVHGVLEQAPDVLLPRHVRLYGECVAAGSDDGPDHVRRAGPVPARSVPVRGPAGRAPPVGGLRPEVDEEELSARCVRAGVRYRRPAGLLVDGGPTTATTVRLSLCHLAEGDLVEAASRFAKGVRRATRAPSGSGVVILKADGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6I5</accession>
    <name>A0A7W7T6I5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HAF family extracellular repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014262">
        <property type="entry name" value="Extracellular_HAF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02913">
        <property type="entry name" value="HAF_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="44227" checksum="14E6785AC05448EC" modified="2021-06-02" version="1">MHDLRLGLDPHPDHSPSIGDSPGKALDMRLLPLGLTLPLALATAAFAGTATASPRPVVVDLGTLPGHAISETIAIDDHGWVAGISYSENLTTSRAVRWDAAHQITDLGVVPGTTRSAASAINKHGTVVGFSYTNDLTDMHAVRWDRDGRTTDLGTLPGAIGSRAVGVNDHDVIVGVALLPGNLQRAVRWDAAGRITELGLPSGDRNSLVGGIADDGVAFGTTYYDLGRSRPVRWERDGRVTVLESLPGDSEGAPVVINDRSVCAGNVYTYGSDQGPHARRWDRQGRVTDLGTLPGARYSQVTGIDDRGTAVGTAQFDDGRTRGVRWDRDGVPTDLGGLGDTTSSAAGIDRRGRIAGTAKTAAGQDHAVRWDRDGRVVDLGTLPGTGLSSWAVGIDDAGTVIGNSFTANGPWHATLWPGPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N8</accession>
    <name>A0A7W7T6N8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6935" checksum="80F502E167277DEF" modified="2021-06-02" version="1">MRSPTPLVERIRSRENGFAPLLALGTGTAPARGGKFDNRPTWDNVPNPFDNRPTWDNWNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6W4</accession>
    <name>A0A7W7T6W4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.187</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.187" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="252" mass="26788" checksum="0902A46050916C57" modified="2021-06-02" version="1">MGAVDVWAVRESAVADHVVRAWRSGDGGAIVTANVDIVRAATRDRSLAALIAESEVVVADGMPVVWAGRLAGVDVPERVTGSSLVYTLSEAAAREGRSVYLLGGDTGVPEKAAAALVALYPALRVAGTDSPPFGFDRDETGTAEAVAKVAKANPDLVLVGLGFPKQELLIRRLRAELPDAWFLGCGAGIPMAAGEFKRASSTVQKLGGEWLHRLALEPRRLAKRYLRDDLPFALRLLAQALRSRARRDNKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T734</accession>
    <name>A0A7W7T734_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional LysR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="287" mass="30994" checksum="65872119FD1E329C" modified="2021-06-02" version="1">MEIRELRYFRAVAEDLNVTRAAKRLGIAQPPLSRALRQLERRLGVALFERTGHRLTLTRAGETLVTEATAVLDALDAAVRRTRRAGLPADGLVVAVHPGVATELVHRVRERFRGEPDVPTIRVAPGGLGEQADMVRDGRADVAIAACVDDRGLDTEPLRTEPRVAALASGHRLAGRDVLTNADLAAEPTPRWRDRPGDGPVVRDGAELLEVVALGQAVALVPVSVATRNVRPDVTYRPVADAAPYRTFLLWPAGSRSPRIARFVRAALDLAGPSTPEVLAREANPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7G7</accession>
    <name>A0A7W7T7G7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021228">
        <property type="entry name" value="BrxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10923">
        <property type="entry name" value="DUF2791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="440" mass="47724" checksum="6807D347DFD524CF" modified="2021-06-02" version="1">MTGPVSEARRREVVAALRRGTVPQAGLDLFAVGLDRFVTAMDEDLATASKGGAAFHAVRGEYGSGKTFFARWLAERAKRSGHATAEVQISETETPLHRLETVYRRLTERLTTATHRPSALGPVVDSWFYTLEEEVLDAGEVAEDDRDALSEAVDALLEQRLAEVARTTPAFAAALRGYRRARVEGDAATAEALIAWLGGQKSVATSARRAAGVRGDLDHFAALGFLQGLLTVLRDCGHPGLLLVLDEIETLQRVRTDVREKGLNALRQLLDEIDAGRFPGLFLVITGTPAFFDGQQGVQRLAPLAQRLATDFTTDARFDSPRAVQLRLPGFDLDRLTELGSAVRDLYAGVARHPDRIGSIVDDAYVAKLAAAVTGGLGGRVGVAPRIFLRKLVADVLDRVDEYPEFDPRVHYALTMTSAELTEVERNAAAGADDIELDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7K6</accession>
    <name>A0A7W7T7K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="180" mass="20626" checksum="BF8E21A4DA049DD7" modified="2021-06-02" version="1">MECTWRAKAREWYREPGVRPVAVLAPVTAVLAVLLPEVAFWTGVGVAVFTWRGISKWTNTRRLVVAVEVDRDARQLLIRSRSGKTHTYSLDKGLVVRPIQRGRRTVVVHEREDDEISETDEIHVHLGIAMDTFTLYYSMTTESLPRTLDAFRGIGKKVRIKKVLDRRTTSYDVEADRPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U2</accession>
    <name>A0A7W7T7U2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (UPF0147 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="301" mass="33605" checksum="3571370F3286AA8C" modified="2021-06-02" version="1">MNAYTDLVRELKSLRKGRGVLAGRIGERVGPTLRATCGVTDDDEPRVIRRKVSDRLVELAGMLPADLRAATLAAFAIDQEARFPLYQDRVHWTAVRMDRDPRTIRRRVDEAINHLAELATEPPERPVVGSDGWRTTELHAVLVLDRSRPEVIERHRIVAERDGLRELALVSPFPAVRSAPDMHVLYGGTLVDRAGPVLAMPAPLAAGECHDFSIRFRPKALGVGQPGLVYVPRQPCDLLELRGRFGPHAPSHVWTVRGTDRDRSGDRHPVDGAGEFRMRFRLLKPGLAYGVRWQVPGERCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V7</accession>
    <name>A0A7W7T7V7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="193" mass="21254" checksum="CAA1787FA4638B97" modified="2021-06-02" version="1">MVKLVTVIGSTRDGRFAPVVRDWFARQVGLRDDIEHDVLDLADVRLPDALPAYGEQPAPAVAAAVEAVRPRLAAADAFVVVTPEYNHSFPAALKTAIDWYYAEWSAKPVGFVSYGGVGGGLRAVEQLRQVFVEVHAVPVRDQVSFHSGWERFDEHGEPHEAEAVGGAAKVLLDRVVWWADALKDARARRPYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7X3</accession>
    <name>A0A7W7T7X3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron complex transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="265" mass="27961" checksum="0D86AA89FD06CAE0" modified="2021-06-02" version="1">MTDTLLAGRDLVLAHHGTAVVHGVSLDLRAGTVTALVGPNGSGKSTLLRSLARLHRPADGAVHVDGAHAESLSGKEFARAVTLLTQQRPTPAGVSVRDVVGYGRHPYRAGWRGVDVDGVRAVERAMALCGVTAMAGRGVDELSGGELQRVWLASCLAQHTSVLLLDEPTNHLDLRYQVEVLDVVRDLADEGVAIGVVLHDLDHAALVADHVVLLREGRALATGTPAEVLTEAHLTDAYGVTVRVTHDPETGAPHCRPVGRHAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T853</accession>
    <name>A0A7W7T853_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiple sugar transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="390" mass="42345" checksum="125B25776537455A" modified="2021-06-02" version="1">MAEIVLDKVTKRYPDGAVAVRDVDIEIADGEFVILVGPSGCGKSTTLNMIAGLEDITSGELRIGGERVNERAPKDRDIAMVFQSYALYPHMTVQENMAFPLRLAKVDDTTVDRKVRDAAEILDLVDHLDRKPANLSGGQRQRVAMGRAIVRNPKAFLMDEPLSNLDAKLRVQMRTSVSRLQKRLGTTTVYVTHDQTEAMTLGDRVVVMRGGAVQQIGAPQHLYDHPANLFVAGFIGSPSMNFVPARVEDGAVRSGLGDVPLTDRVRGLLERADAPREVILGLRPEHFEDARLVDDPARGVTFSGHVDVLESMGSDKYAYFGLPERATSDHLAELAADAGAADVPGSDVALVTRLSAASTATEGQEARVWFDPDRVQLFDPKTGANLTYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T855</accession>
    <name>A0A7W7T855_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase subunit of ABC transporter with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="347"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="542" mass="58167" checksum="E0526AA99BC8D27C" modified="2021-06-02" version="1">MSATLVAKGLAAGHGDRVLFSDLDLVVAPGDVVGLVGVNGAGKSTLLRTLAGLLPAESGVIRLSPTTATVGHLPQEPERRPGESVRDFLARRTGVAAAQAELDRTTALLAEGRDEGYSEALERWLALGGADLTERADEVAADLGLTVNLDQAMTSLSGGQAARAGLASLLLSRYDVFLLDEPTNDLDLDGLARLERFVAGLRAGAVVVSHDREFLARTVTRVVELDLAQNQVRTYGGGYESYLEEREVARRHAREEYEEYASTRSSLEDRARTQRAWMEKGVKNARRKAPDNDKVGRKFRTESTEKQAAKARQTERLIERLEVVDEPRKEWELRMEIAAAPRSGAVVAVLRSVVVERGTFTLGPVDLQVDWADRVAITGANGSGKSTLLAALLGRVEPAAGTASLGPGVVVGEIDQARGLFLGGEALVDAFCAAVPDLAPADVRTLLAKFGLKADHVLRPAASLSPGERTRAALALLQARGVNLLVLDEPTNHLDLPAIEQLESALDSYNGTLLLVTHDRRMLEAVRTTRRLEVAAGRVTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8K1</accession>
    <name>A0A7W7T8K1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Stearoyl-CoA desaturase (Delta-9 desaturase)</fullName>
            <ecNumber evidence="10">1.14.19.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="PTHR11351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="59"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="318" mass="35563" checksum="8C7B8C63F2FA51ED" modified="2021-06-02" version="1">MTSTLESGSAAPPSPDRGPKPLIGGQRGHLEQLGVYVFVIVPFLALLAAVPFAWGWGLGWVDVILFVAFYYISGLGVTIGYHRYFTHGSFKANRALKIGMAIAGSMALQGPVITWVADHRRHHAFSDREGDPHSPWLFGSGPVALAKGFWHAHMGWLFERDKTNAQRFAPDLLEDKDLRRVDDLFWLWTVISLAAPAVIGGLVSMSWWGAFTAFFWAGFVRAGFLHHVTWSVNSICHMVGDRPFAARDRSANVWALAILSFGESWHNLHHADPTSARHGVKRGQIDTSARIIWIFEKFGWATDVRWPTPQRLARISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8S7</accession>
    <name>A0A7W7T8S7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_005800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="213"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="45616" checksum="AD940A1BA4FFD80E" modified="2021-06-02" version="1">MNPRRWWLRRTLRFRITVVATGVALLCLLALTLLAPRLIGFVQVSAVDRELSRAGVTRVLDVAGVPLDGGGFLDLTPSDIRSLKAGESVLRLDGASAHRWTGRVVFAADGTPELHVSGDVLVGYQEANELGTRWLAVAAVLVAGLVGIATWLAVRSSLRPVERMRAAAGELPRGQRLPVPAARDELQALAEALNALLARRDEATERLRRFTGDAAHELRSPVTSVRAQAEVAVAHPDPDFSIEVLESIVEESERLSALVDALLLLARADTGELPRAEPVDLALGAQSAVDRLGSKELLVQVSAPISACLISAAHTEVELVLDNLLRNAARHARTLIRVSVLPAGRQVRLLVDDDGPGIPEEHRQKVFDRFYRVDSDRGRATGGFGLGLALVAHLVSRRRGAVRATESPEGGARLEIRWPAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8U0</accession>
    <name>A0A7W7T8U0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PKS_ER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="35148" checksum="FE60FA760ACE36FF" modified="2021-06-02" version="1">MSAPTTAREFRLASRPTGYPTREDFTLAEVAVPEPGPGQILVRNRYLSVDPYMRGRMNAGESYIAPFEVGEPLEGGAVGEVVASGSDEFAVGDAVWHFLGWREYALVDASAAQRLDAPSSHYLGILGMPGLTAYVGLVGIAPVRAGDTVFVSGAAGAVGAAAGQIARRLGAGRVVGSAGSPEKVRLLVEEFGFDAAFDYHDGDLAGQLREAAPDGVDVYFDNVGGEHLEAALEVANAHARFALCGWISGYNTEPVGVRNLGLVVGKRVTLRGYLVRDHEEEYGEAFRRDVSAWLSDGGLKYRETITDGFENTPGAFIGLLRGENVGKAVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W5</accession>
    <name>A0A7W7T8W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="236"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="429" mass="45528" checksum="34A27BF9FFEED276" modified="2021-06-02" version="1">MPAYAGGGEADTARRSGMFGSLRVRNYRYYASGQVVSLVGLWMQRVAQDWLVLELSDGSPVALGIAAALQFTPTLFLSLWAGVLADRMDKRRLLVGLEIGLGLCALVLGLLDVTGLVQLWQVYLLCLVLGAVAAVETPVRQSFVVELVGRDQLTNAVALNSMTFNLARMVGPAVAGVMIIAVGTGWVFLINALSFVGVIVGLLRMDAAKLHRGEPVPREKGQLVEGLRYVRRRPDLVILLCLVFFISTFGLNFYVTLAVLARNTFGGDADAYGLLSTLLAVGTLAGATLAARRSARGRPRLRLLFLGSLAFGVLEIAAGLMPSLWLSGAVLIPVGIAMMTFTTTANATVQLSVAPAMRGRVMGLYMLVFLGGNPLGGPVMGWLAEHFTPRAPLVVGGVVAILSAVVGAVVLARRGGVTLRATLNRGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8W7</accession>
    <name>A0A7W7T8W7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_006058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="380" mass="40554" checksum="941892CCF211BE5E" modified="2021-06-02" version="1">MPAERLLPTTEAEDLLSLVREISREELAPHAAAAEEASAFPRDKFLLLGKSGLLGLPYPERFGGGEQPYEVYLQALEEIASAWMSVGVGLSVHVMSTYALAAFGSEEQRQRWLPDALGGSWLGGYALSESHAGSDAGALTTRAVRDGDEYVVDGTKAWITHGGVADFYTLMARTSDTGGKGISCFFTPGGSDGIEAAKPERKMGLTGSVTAQVSFTGVRLPADHRLGDEGDGLRIALSALDSGRLGISACAVGLAQAALDEAVAYAKQRTQFGRAIIDFQGLEFVLADMAAAVESARATYLAAARRRDLGLPFTRQAAIAKLVCTDAAMKVTTDAVQVLGGAGYTRDFPLERYMREAKVLQIFEGTNQIQRVVIGRELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T948</accession>
    <name>A0A7W7T948_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding LacI/PurR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="347" mass="37099" checksum="7CB1F706B31D7992" modified="2021-06-02" version="1">MPGLSEIARAAGVSISTVSRVLNRRAGVNEETRQRVLAVLSEMPYTPRGIGALQRTGVIGLLVPELSNPVFPAFAEALEVRAARLGYSSLLCNTRPTGSAAMGEEEYVRMLLARGVEGMVFVSPEITNTEVPLGQAPRPSYYAKLLADGVHMVFVNGATPALDVPDVTVDEQHAGYAATRHLIDAGHRRIGFVSGPARSLPSRLKRAGWSAALEEAGLPADSAFVAHAAYDPEGGAVAVGTLLDTIAPTAVICSSDYMAIGVLREVHRRGLSVPDDLSVVGFDDIRLAAYCSPPLTTLAQPIEEMAAAAVDELVQRLDPDRRRRQSGNYTRVFRPRLVVRQSSGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T955</accession>
    <name>A0A7W7T955_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="9717" checksum="F2CAD2CF7F581896" modified="2021-06-02" version="1">MNAAKRWAAAHEARTLTGAHEALGRVMPAPNAEASVWVSFHQAAAKVYDQVAEADQRHHYEARAWAQCERNRLDALMGGSGEVSGDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T980</accession>
    <name>A0A7W7T980_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="108" mass="12223" checksum="1077670D5C7F1B9B" modified="2021-06-02" version="1">MSFKEELLAELEDCLRGYGAVPVHHPGSLARFIDYVRRLPEDDPRLRGLAGVDQGSGSFWNNPAVWWEQVPRFDSMVTGCSELLDNMLDEAIADEIDVLEMEIREMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B1</accession>
    <name>A0A7W7T9B1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="12" type="ORF">F4559_006307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="47"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="27597" checksum="A433CCD729A2C44D" modified="2021-06-02" version="1">MAKRPETQLGLTRRARRTVRVLAEGYPDAHCELDFTTPLELLVAVVLSAQTTDVRVNQVTPALFRRYRKAADYASADRAELEEFVRTLGFFRAKANSLIGLGSALVEKFGGEVPGKLDDLVTLPGVGRKTANVVLGDAFGVPGITVDTHFGRLVRRWGWTEEEDPVKVEHAIGKLIERKDWTLLSHRTIFHGRRVCHARTPACGACFLAPQCPSSDVGQQDPVKAQKLVKGDEAPHLIALAERVRAGEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9B6</accession>
    <name>A0A7W7T9B6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">F4559_006234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31449" checksum="42B4AAC03E81F2BA" modified="2021-06-02" version="1">MTKPLSKDDYAPNDVTVHRDPARLARVVAALRAAGRNIALVPTMGALHAGHRKLIREAHVMQNTVVVVSIFVNPTQFGAGEDFERYPRTLDADVDICREERVGLVFAPEPADMYLPGSTVTLDPGPLGGELEGASRPGHFAGVLTVVAKLFNIVRPNYAVFGEKDYQQLTLIHRMARDLDFPTAVVGVPTVREHDGLALSSRNRYLSAAERETATALSAALVAGAHVSGQGGDAVLRVAGETLASVPGVEVDYLELRAPDLGPAPENGDARLLVAARVGGTRLIDNIAVLLGTGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9C4</accession>
    <name>A0A7W7T9C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kynureninase</fullName>
            <ecNumber evidence="5">3.7.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="PTHR14084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="135"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="39954" checksum="D97CA7DBADB58412" modified="2021-06-02" version="1">MIRELFDLDDDVVYLDGNSLGVPPRHVAARVNEVITQQWGRRLIRSWSEGWWETPERVGDRVGRLVGAAPGQVVVADSTSVNLFKALMGAVRGTERGEILVDAGTFPTDGYIAQSVAELTGLTLRAVDPESFEVGDAAVVLLNHVDYRSGRLLDMASLTEHVHAGGAKIVWDLCHSVGVLPIELDRLGVDLAVGCTYKFLNGGPGAPAFLYVPKAAQEDFHQPLTGWTGHAVPFAMSQDYTPDQGISRARVGTPDILSMLALDAALDVWDQVSLADVRARGLELTAYFRRLVEGLPGIEVITPDSEWRGHQVSLRHPDAARIMGELIARNVIGDHRPPDVLRFGFAPLYNTDEDAERAARALQELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9D4</accession>
    <name>A0A7W7T9D4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9822" checksum="048496F319572C45" modified="2021-06-02" version="1">MTAWFVIAVPIVIMFFALFMERVEARLRHVAVQEDEVEEFLESARPDEVRALYGHGIGRALELFRLRRLGGRARSLRQRRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9W1</accession>
    <name>A0A7W7T9W1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="10829" checksum="8F7F10512AC72E40" modified="2021-06-02" version="1">MTTLEGFRPIAEVAADERSRIAFGKAGVHKDDRYAVSINDEGAILLTPLASIPKRELMVWENDELRASLFRGLADAAEGKVQKLDWVTAGVEIDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z2</accession>
    <name>A0A7W7T9Z2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="234" mass="24017" checksum="1981924CD517DD70" modified="2021-06-02" version="1">MSGASARRFPTVERPMPVRHLGWCPGAGTCRGVVPGCCFFFVHLLEGKTATAVGPVDCVDNPRPPSSRPSRGCGQTGGCTRGQLGAPGDNSAAVHSHPQIRRVVPGCIPGCGAGCPRVLHRAGVARISSKVCRFLPVDRIFEQSDLCGRPAAALVGHPAPGCGDAGHPGADESAPGCGGGTVPGCAPGCAAVRNARRAPSPRGRGRAPVDGARRGQGVWRACCLMRDVSSWTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TA56</accession>
    <name>A0A7W7TA56_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="203" mass="21972" checksum="8053F989F0B07090" modified="2021-06-02" version="1">MNVRSLTPAGLVADLVGRIDALPRDGFARALVDGATAARPDHLADALVEPLRALGRPVLRVSTGDFLRPASLRFEHGREDPDSFRDGWLDVDGLVREALAPLDPGGNGRVLPSLWNAATDRATRADYLTLPPGGVLVVAGPLLLDKWLPAELTVHLWLSPAALARRTPDDERWTLPAYADYTPEADVTVRYDHPDRPALVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG7</accession>
    <name>A0A7W7TAG7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_006877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="368"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4969518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="51529" checksum="BAD6532386060B5A" modified="2021-06-02" version="1">MSKPRIANVLAGRYASTELATLWSAEHKIVLERRLWLAVLRAQAGLGIDVPAGAVEDYERVVEQVDLASIADREKVTRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQVLRSLEFVRGKTAALLARLARLAAEYTDLVMAGRSHNVAAQATTLGKRFATAADEVLVAFRRLEELITRYPLRGIKGPVGTAQDMLDLLGGDEDRLVELEQAVASHLGFERVLTSVGQVYPRSLDFDVVSALVQLAAGPSSLAKTIRLMAGHELVTEGFKAGQVGSSAMPHKMNTRSCERVNGFAVILRGHLAMVGELAGDQWNEGDVSCSVVRRVALPDAFFAFDGLLETFLTVLDEFGAYPAVVGRELDRYLPFLGTTKVLMAALRAGVGRETAHQAIKENSVAVALAMREQGAGNDLLDRLAADDRLPLDRAGLDALLADRLSFTGVAERQVADVVRQVEEVVGRFPEASGYAPAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAH4</accession>
    <name>A0A7W7TAH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="229" mass="25259" checksum="77C254C26DBF0521" modified="2021-06-02" version="1">MGIPAWVWFTVAAVAGVAGFALLATDRAQRTARNRERRRWAALRGWQFEETDHVLPTRWESGAIAYYGTGTAKDVVAGSTFTADGRRQVYVLDHENGGKVNSVLVGVRCRRSVPVVVELWLPTVPFQRDQMPDLLGPVGSRYAFVGDVPAARKLITPDLVDAAEEIGGDVTVVWLEDDWVLAAAPPNSSPTRIERLLRDLGELADVVDPFDADSEPEAEIHRPQFGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAJ7</accession>
    <name>A0A7W7TAJ7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="205"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="535" mass="59427" checksum="ED06DA1C40F9B72A" modified="2021-06-02" version="1">MLKLCLRMPPGAEWRWNGEHWSDGVSTIRPYAHPMLEHAAVTDGVSTFVVVRERARQVAGFGAADVFTTADTPTYLRLLDEIKAWPLDFVLIECTPPDGYRITSGTWGTAPLYLTDAGERLRGSWSLPDLRQQFSLDALDERSVARLLTERTRYARETLFRGVYMLTERAHATYGDDGLVMHYPAPAEHASPREIRHDVDVVEVYRRVLSDAVYARPFEPQTAAVELSGGMDSASVAVALAEQHRGEVLSYALAIGGEAGEQQLRRRAEMLLYLGFPDLTVDALPLAPLNPDGARARGLFVEPGAEPYHEAVGTILAAARGQGVRTVFTGDGGDELLSLRGDEWASVGKVRGRFSDHERLPPWLGRRTADQLDAVDDDLAPPTVINEATLLGFALRSPQFLDAGIWPVSPLCSPRLIRFAEQLPVSWRVDKHICRERFHRIGFSHDARYPHLRENFRHVMGAGLREYGMPLLAELLAEAVTVDLGFVDGDALRAALERWKHGEQVDMKVFPVLSLELALRAMTAHRGEREGALCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TB33</accession>
    <name>A0A7W7TB33_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron uptake system component EfeO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EfeM/EfeO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14656">
        <property type="entry name" value="Imelysin-like_EfeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018976">
        <property type="entry name" value="Imelysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034981">
        <property type="entry name" value="Imelysin-like_EfeO/Algp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038352">
        <property type="entry name" value="Imelysin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09375">
        <property type="entry name" value="Peptidase_M75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031265499" evidence="3">
        <location>
            <begin position="30"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M75" evidence="4">
        <location>
            <begin position="138"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="374" mass="39926" checksum="823C099C03894935" modified="2021-06-02" version="1">MSTATRSLGLGSLLLLLAACGGGGGTPSADGPIAVEATDDACKVAKNTAGTGNVTFEVTNKGTKVTEFYLYAEGDRILGEVENIGPGLTRRLIVEVTEAGKLQTACKPGMKGDGIRADFTVTGDAKKATDSDAKLAEATKSYQRYVNSQADSLLTKTTEFVDAVKAGKVEDAKALFPVSRTYWERIEPVAESFGDLDPRIDGREDVIEEGLEFTGYHRLEKDLWETGLQPDSAAIADRLLTDVKEIVEKAKAVELTPLQLANGAKELLDEVATGKITGEEDRYSHTDLWDFRANVDGSQAAIAALRPVIAEKDAALAATVDEKFKALDALLETHRKGDGFKLYTELSEAEVKALAEAVDALGEPISKVAEVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TBE6</accession>
    <name>A0A7W7TBE6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ORF">F4559_006074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="41"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="377" mass="39860" checksum="1916E2C7B4931991" modified="2021-06-02" version="1">MTQTADPTTLVLPADLRPSDGRFGCGPSKVRPEALAALAMEGAALLGTSHRQKPVKSLVGEVRSGLRDLFSLPEGHEVVLGNGGTTAFWDAAAFGLVRERAQHFVYGEFSSKFAKVTGDAPFLGDSIVVKSDPGSAPEIAYAEGADLVGWAHNETSTGVAVPVSRPAGSDGALVAIDATSGAGGLPVNAEDFDVYYFAPQKSFASDGGLWIALMSPAALERVAEIGASGRWVPEFLSLTTALDNSVKEQTYNTPSLSTLFLLNEQIKWILGNGGLSWAVERTADSSSRLYSWAEATSYTSPYVADPAYRSQVVGTIDFDDSVDAAAVAKALRANGIVDVEPYRKLGRNQLRVAMFPAIEPADVTTLTKAVDWVVSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TCV6</accession>
    <name>A0A7W7TCV6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="17013" checksum="43226523DBA74FEA" modified="2021-06-02" version="1">MAATLRRHTLFPPGDSQDDLAYAAEALHGHTRLVGPDGTEIKLPGEVFAALREVVEALSNGLAITIAPQTTQLTTQQAADMLNISRPTLVRLLEEGQIPFEMRGRHRRVRLTDLLDYQEHARVHRRTALNELAREAVEDGSYDAVDHFPRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TD10</accession>
    <name>A0A7W7TD10_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="129" mass="13533" checksum="1B36D7A307178192" modified="2021-06-02" version="1">MFIADGGGGSTQAPIPEYSGSQQKLSVDPSAIPEARKVFAEALGRLENTLNGALQGIQARNWAGDPVSKETADKFNENTFGAGDSAAFSAIVAYRNQLQGVVDQLTAIEADYRAVEGDNTAAWGRVNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT40</accession>
    <name>A0A7W7WT40_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="274" mass="29192" checksum="5D5CF278DB89E8C1" modified="2021-06-02" version="1">MTVLPSRPAQPVDPGLVSIALEIAGRLANDASDVIVATAGRGARPDDDPYPFDWVTDTDRTLERHTRRVLASEFPDIPVFCEDTDAHTVSDAEYRWVVDPVDGTANYVAGMPWCAYSLALVDRWGPVVGVVADPYRAQIYAAARGRGMRANGRPVRLGEQPVSPIVCTELTRTGPWPGMGDFITRAASAGTGVRMLGSKALAVAQVALGHAAAAVLDSYHEWDVAGAVALAVESGATVLDRRGDDVSLPVDGLLVAMPDSAEEVLGWWQSSMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTD8</accession>
    <name>A0A7W7WTD8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="16179" checksum="715C380B31EFD74D" modified="2021-06-02" version="1">MPLYAAYGSNMDPNQMMERAPYSPMAGTGWLAGWRLTFGGEDLGWEGALATIVEDPDAQTFVVLYDVSPRDESQLDRWEGALGLYKKIRLRVQTLEGSVVAWLYVLDAYEGGLPSARYIGVVADAAEAAGAPDDYVADLRTRPCTGIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUD9</accession>
    <name>A0A7W7WUD9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="261" mass="26888" checksum="69B1D249387A6477" modified="2021-06-02" version="1">MRVALCQIASTADPEANLDLLRAGVDQAHGARVVVFPEAAMCRFGVPLGPVAQPLDGPWASAVRKLADAAGVVVVAGMFTPSADGRVVNTLLVTGGDLHVGYDKIHLFDAFGFAESRTVAPGTEPVTVTVDDVTFGLATCYDVRFPELFRTLADRGATAVLLGASWGAGPGKREQWELLVRARALDSTSYVLACGQADPGVDHGGAPTGIGHSLAASPLGEVLVGLGPEPGVVMVDVDDAAVAQARRTLPVLANRRLSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUJ2</accession>
    <name>A0A7W7WUJ2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="14" type="ORF">F4559_001530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="68"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4964171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="412" mass="43970" checksum="C38A4FE04B53AA2D" modified="2021-06-02" version="1">MRENALSSGQLTPTPHDPDERGHFGPWGGRYMPEALIAALDELTVFYEKARIDPDFLDEFARLLRDYAGRPSLLTEAPKFATHAGGARIFLKREDLNHTGSHKINNVLGQALLTKRMGKKRVIAETGAGQHGVATATACALLDLDCVVYMGEVDTERQALNVARMKLLGAEVIPVKTGSRTLKDAINEALRDWVANVDDTHYLLGTAAGAHPFPVLVRDFHRIIGIEARQQILEKAGRLPDVVAACVGGGSNAIGIFHGFIDDPSVRLVGLEPGGDGVDTGRHGATLTAGRPGSLHGAMSYVLQDEDGQIAEAHSISAGLDYPGVGPEHSHLKDIGRAEYRPVTDKEAMDAFALLSRTEGIIPAVESAHALAGALVLGRELGPDGLILVNLSGRGDKDMDTAIKWFGLGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUS5</accession>
    <name>A0A7W7WUS5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_001755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="11"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4964396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="597" mass="63011" checksum="45CD2EB86AD7F92F" modified="2021-06-02" version="1">MSANVLAEMRIQGLGVIDEATLELDAGFTVVTGETGAGKTMVVTGLHLLGGGRAEASRVRSGADRAIVEGRFSAPAGSPAAKAAEEVGGEPDEDGSVIAIRSVSADGRSRAHLGGRSVPVGVLAELAEQLLAVHGQNDQLRLLRPAEQRSVLDRFAGDEVAGPLREYRKIRDEWLRVAAELTERTERARELARESELLRHGLAEIGAVDPKPGEDAELVLEARRLADADQLRESASGAAYAVSGSPDGDPDNPGALGLIGEARRRLGSSEDPRLRDLEPRLVEAETLLADVGAEIVAYLDHLDADPARLERVLARQAELKSLTRKYAADVDGVIEWAADASGRLSGLDTSDEALAVLAARRDELAGQLAEFALRVTAAREDAAQELGKAVSEELTGLAMPHATVEVVVRPRVAESGDPQALPVGGRSLHAGASGVDEVELRLIAHPGAPALPVHKGASGGELSRVMLALEVVLSHSDPVPTLVFDEVDAGVGGRAAVEVGRRLARLARSHQVIVVTHLPQVAAFADRHLVVDKTADGVLTRSGVRRLDEPQRVVELARMLAGMDSTDTGRAHAEELLAAAKADKDNVPVVRRKGKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV84</accession>
    <name>A0A7W7WV84_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YkwD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031037093" evidence="1">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="80"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="20922" checksum="423C0B42909D4E8B" modified="2021-06-02" version="1">MPRNHRVLPAVVLVGLALAGCAEADRATELTATATTTVRVVVTTTTTILTPTVAATEAPTPEAVVPTRPENEVVEEKVVELTNAERARVGCAPLVADDRLARAAREHSVDMAAKNYFEHHSKDGRSFVDRVKAAGYPAPGAENIAAGHKTPELVVKGWMDSPGHRANIVNCRLKAIGVGMARGGSYGIYWTQNFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV96</accession>
    <name>A0A7W7WV96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="60"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="196" mass="20339" checksum="5CE098C55DC7A103" modified="2021-06-02" version="1">MVDPHLGLFLFVVGVATDSPPFVRTFGVIATDAVLGVFAVLFLVSWWRARTAGAERMAKALLAPAATVVAGLVGEVIKLLFREERPCHTTAGIAPCPAPDDWSFPSSHSVIAGSAAVALALVAGRVLRRIALACAVFTAASRVFVGVHYPHDVAAGLLLGALVVTFLPMAARRAAPVVARLRSGTPGRTLLGAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVA3</accession>
    <name>A0A7W7WVA3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar lactone lactonase YvrE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030794145" evidence="1">
        <location>
            <begin position="26"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="SGL" evidence="2">
        <location>
            <begin position="40"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="304" mass="31748" checksum="272ED0FB112A3024" modified="2021-06-02" version="1">MRLPRGTVVCVAALLVLGPSGVAVAEPFPTTLGLPDGFRPEGIAVDAEYAYFGSMGTGAIRRVRLADGTSTQLTPGAAGTAALGLKVDGRGRLFVAGGGGGDARVLDTATGRTIATFRLATRSTFVNDVVLTPEAAWFTDSTTAVIHRLPFGADGTLPAKAQAVRLSGDIRYTSGTNANGIETSPDGKSLIIAQHNTGRLFRVDPATGATREIQVAGGPLADTDGLVRDGETLYVVENRSNRVAVVKLDAPGTRGALVKRVTDPRFDVPTTAALYRDRLYLPNGRFTTTPMPDTPYTANAIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVB6</accession>
    <name>A0A7W7WVB6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate--cysteine ligase EgtA</fullName>
            <ecNumber evidence="2">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Gamma-glutamylcysteine synthase</fullName>
            <shortName evidence="2">GCS</shortName>
            <shortName evidence="2">Gamma-ECS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">egtA</name>
        <name evidence="4" type="ORF">F4559_002265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01014"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052699">
        <property type="term" value="P:ergothioneine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02034">
        <property type="entry name" value="EgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017809">
        <property type="entry name" value="EgtA_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035434">
        <property type="entry name" value="GCL_bact_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011556">
        <property type="entry name" value="Glut_cys_lig_pln_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378">
        <property type="entry name" value="PTHR34378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34378:SF1">
        <property type="entry name" value="PTHR34378:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="371" mass="39910" checksum="B553644B4703B17E" modified="2021-06-02" version="1">MEIEWTVHHADDPARPLDAARLAAALGRHAPPTLVPDSTQEPLPGGTPLTVEPGGQVEISTPPSDSLAELLKTVTADIDHVTGLLEPAGLVLGERGADPHRPPRRLLQVPRYAAMEHAFAPLGPEGLTMMCSTAGLQVCLDFGERADLPRRWAAVHALGPVLTALFANSPGVGGRRTDWASARMRSLYATDPIRTRAGAVCADPATAWARRVVDAPVIVVRRPGSSWLPPFPLTFAEWIDGALDRRPTAEDLDYHLSLQFPPVRPRGYLEIRYLDTPRHGHWMPPVALLAALFGDEAVVDAVLAATEAAAGRWLTAARVGLADPVLARAAREVVDLGCAALHRNDLSAHQNAAIAEELQRTLVERTRGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVR4</accession>
    <name>A0A7W7WVR4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030509494" evidence="1">
        <location>
            <begin position="28"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="183" mass="19314" checksum="0906B5CA3BE34F1D" modified="2021-06-02" version="1">MFRGLRRVTCCLVVLLTGVGLVGPASARPGEADRGLSVDHVVGTVAAGRRAVFNGPGVGPSLARIEAPDAAIICDVGYGNDVTLYDGFLHVTWSVACRDTATGKPTPLARDIRMLIGIRNGKNFIPPVSDLCITPGPTATCSHRVPYGGTIGWHDSKMAVVVNWTDDYEPIAGVFITPGFRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVS1</accession>
    <name>A0A7W7WVS1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component alpha subunit</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="53"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="365" mass="39448" checksum="8CC18DEB14E7A388" modified="2021-06-02" version="1">MTRTQAPRSSPSRTSPSHLLPTEEPLALLRPDGTPVEGSPLVMPADDVLVELYRRMVVGRRFDTQATALTRQGRLAVYPSSRGQEACEIAPVLALRPDDWLFPTYRDSVALVSRGIDPAQTLTLLQGGWHLGYDPYEHRVGPQCTPLATNTLHAVGFAHAARLKGEDTAALVLLGDGATSEGDTHEALNFAGVWQAPVVFLVQNNGYAISVPLDKQTAAPTLAHKGIGYGVPSVLVDGNDAAAVYAVVRDALRTGGPTLIEALTYRIEAHTNADDATRYRTSDEVAAWLARDPVDRLSAYLTARGLLDERTKDDVAREAETFAAAVRAALNVDVEPDPADLFEHVYATMPAHLRAQAEFLREESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WVX8</accession>
    <name>A0A7W7WVX8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030508562" evidence="1">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="31719" checksum="220D49F5F6E1525D" modified="2021-06-02" version="1">MKRTTRMIAPALVGIAALLGGCAAETGAPAPTTTTSPAPPGLVGALSRVKATHEGAAYVEYGDLAALRGYDVDRFKTVAHVGLSDLAPRGAKIADVTGFDPTAADTVLRVGQPPKWAGVLRMKVPVDAVNGKFEGLGAQREDGGGGTTWTTAKDNAVDLAGPFGSLGVMAAFNQVRVTPDGLFHAPSAETLGWFTAPGDLTLDRHPAVGPLARCLGDVVVAVIANPLGRLPVAAGVRVVDGVATDVLCGGAAGVDRVRDNVAAVAARPGAPAGIADAAVEADRDDLVRVVVPTGDGPVGRTVRMITTGDAASLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWG9</accession>
    <name>A0A7W7WWG9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+-transporting ATPase KdpF subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="33" mass="3404" checksum="A63083D7CD5A86BF" modified="2021-06-02" version="1">MSGTGVVANAVGGVLALALIGYLFVVLLRPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWM7</accession>
    <name>A0A7W7WWM7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="712" mass="74314" checksum="3785C86AA13E9BC1" modified="2021-06-02" version="1">MTEETVMRADLRGSASRDVGLLLRELAVGEFRNVVLVVETASLTTQRQDLEKIALKAGAAILVVVGPVAAEHGPVLDLPSVLSRVAAVLWVGADEGVRWTGGSQPAGPGRAGLDDLLRVLDQPKVFRKVREEVLGLPHQTASPGLEVEYLTVDPVAAGEVKAEVLRRLVAVGPATRSADHESTALKAFAEAVGAPPKSAGFVPGSPLAAVEGAAADRLAAASRALAPVAGVRGLLGRNRMLPKAALAAVADAVENQFAVAKGTIADIDTSLGRGVPPPTELVERGLPVPERVDHDALTGDLRAAVAAELRAKRTLRSLAAQAQKHGSHLGVSRGLVSDSAVTLPDPGPVVDRLRAPAACQWLPSPQSYVWLAALGTAAAAGWLPAIGRLLGPLVVLLWVVCVAWACHRLPAPATGARWAAASTGVVGAIGCACGLLSGPVPLPSAVAAAAGVVLVLAVPAIVAAAWHRSVTRWVRGLGLREVGELSGSQVRQYRTAISERWITVERRSGAANALFVLSEVLEVVAEAYKVVVDDHDRGPFRPVPQADTHALLTRVFEHDLVELVLTALEKRFAGIAAGVSYHDDRAVTERQVRDLLGDYQDHLKHRSVVDPPPGVPGGGPRDDLAAGLRRAVPADLWLWNATARDRLTQLCLAGDLRLLDLDGSAMVHVAPPESAGATGAAAVEDVVGALRLTPLRPGLVAWTVDTAKGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWW8</accession>
    <name>A0A7W7WWW8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="123" mass="13254" checksum="A5454240B28C45E3" modified="2021-06-02" version="1">MLCAAVDRELTARAQGLRRYGSSALDLVWVADGTLDACVLLGNHTWDTAAGAVIAREAGALVLDADGSPHSTRSRCAIAMMPGLQDEVLPLLRVLRGSRFWPDDNEPHDLDHRAAPLETEVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX03</accession>
    <name>A0A7W7WX03_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004264</name>
        <name evidence="4" type="ORF">F4559_004839</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="109"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="320" mass="36023" checksum="D0D9C8B0D4E72983" modified="2021-06-02" version="1">MKKSCALTGTSRATHYRHLNPTGPIHGPRPARTPPPQALDADERARVLEVLTSPAYRDLAIPQVWARELDEGRYWCSISTMYRIARAQGQVRERRRIATHPPRTRPELSARGPGEVWSWDITALKGPVKGVWYKCYVVLDIFSRYVTGWLVAAAEDAVLAKDFLAEAIARNGTEPHTIHADRGGAMVSKPVSELLTDLGVLRSHSRPRTSNDNPYSEAQFKTLKYMPDFPDRFGSLADARLFCEGFFLAYNHEHRHSGIGMHTPASVHFGTAGRIRDQRQATLDRAHARHPERFARRPRPPALPEVAWINQPLDQPQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX18</accession>
    <name>A0A7W7WX18_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24630" checksum="1DEB3A0A0DDC4E0E" modified="2021-06-02" version="1">MIGFLRRFRRAPVVVEHDPVVHHGVVVADGTGHGVGDALCSALAVHGIAAYAIDPFEVDAGADVVVLLLPVRPDTMPMPGGTALSVLGRVGADPVAAAAFRSRLVVVWYLRNAARPRLSAPGVGRTGRVWNGSELLLATSWRRELAHHGGDLAAAVRCRSGRVDRMVHAPTHHRLGANLVPDVCRDLRVLDPDLVHGLCVEVADHRVDDTVLRWTGARSVAAAVRVSAAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX48</accession>
    <name>A0A7W7WX48_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein (DUF305 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005183">
        <property type="entry name" value="DUF305"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03713">
        <property type="entry name" value="DUF305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031173442" evidence="1">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF305" evidence="2">
        <location>
            <begin position="58"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="209" mass="22377" checksum="C384842B6CDFF28F" modified="2021-06-02" version="1">MRVVLVVLVLAGVLAGCTGSGDEDVPNVIVPGKPGEQARTLDPDDVGTDRWVAPNEADLRYVASMIVHHRQALDMAALAPDRASHETVRGLASRIHDTQGPEIGAMEQWQRDFGQKAPAHGHSGKLPDVDHAGMPGMATPEQLAALKSAKGTDFDRLFLQLMIAHHEGALKMAVELLSTGSDVRVEEMANDVVASQTDEIGRMRAITLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX78</accession>
    <name>A0A7W7WX78_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine-rich copper-binding protein CopC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031524513" evidence="4">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="5">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="178" mass="18640" checksum="5F94720C10485BD2" modified="2021-06-02" version="1">MRGKLTAFALAAGALVGVVPIVDAAAAPPVLLGSSPYDGDYVTAVPDRVELVFDRQPDSLRASLALYSPGGGVSTASHFADRTMSATVEGTKPTENGVYRLNWVFEGASGNVLFTVLAPGQEVPAGSVGERSRAFESSLTIERDPWSSRLSVWPLLGGAIMLVGVGVWLSPVRRRKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXD2</accession>
    <name>A0A7W7WXD2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="393" mass="42048" checksum="2F1C95599FBA646C" modified="2021-06-02" version="1">MFPNMPDPDEESAAVRVDKLVTAAMRRLDRVTGTHAGNRPPHLAQLDAVLTAAVHQAKQAEAGSSAVDRDSDLWRLREPGYLRAICDHPVDRPGGTLPLVPVVLTWALLGYAEWTYLDDYASAPAADRPSFFADWMTQPVYRSPVALSLAIVATVAVIMYKYRAPARAQRVADEVDRIVHRLEVDLLPPLTVLRGALGPVKVEEHTRQAAVELGAAAKLFTTATARLAESTAVVDRLVAGVERLVTALPELGAQTGKLEEVRRDLDQTAQMISTGLAPLQDLVSDVDGAAKAAKEAVDRSETVLGRAAGQLADADEVAQRHAGHRAALTAAQAPFTAVADVVDKASSRLDATSAQLQEAVSELRKTVAEVNWLVMVSDGLRHGEGEHTDGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXH1</accession>
    <name>A0A7W7WXH1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator DesR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_004455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4967096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="200" mass="21571" checksum="5258AD5FA18F7C54" modified="2021-06-02" version="1">MIRVVLADDEDLIRGALAALLDLEDDIRVVEQVGDGEAAVEAVRRHRPDIAVFDLEMPRRDGVLAAEAVRDLDGVAVVIVTRHARPGVLRRALSAGVRGFVPKTTPAAQLASILRDVHAGRRYVDSEIAAAALTEGACPLTARELDVLRHALHGGTVAVIARETHLAPGTVRNYLSSAMTKLHAGTRYEAARLAWEEGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXM6</accession>
    <name>A0A7W7WXM6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024967">
        <property type="entry name" value="DNA-bd_IS481-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13011">
        <property type="entry name" value="LZ_Tnp_IS481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="332" mass="37732" checksum="5363DB21A4C404DB" modified="2021-06-02" version="1">MTHANAPLTPVGRLRLARCVVEEGWPLRRAAERFQVSPTTAARWASRYRESGEVGMADRSSRPHHSPGRLPTRRERRIVKVRLARRWGPARIAHLLGLNPSTVHRVLRRFGLARLAHLDRATAAPVRRYEHAAPGDLVHVDIKKLGNIPDGGGHKVHGRQAGGRNSSAHRDPARPRRVHGRPNLGYAYLHNAVDDHSRLAYTEILPDETKHTAVAFWHRAQAFFQAAGVAVKRVLTDNGSCYRSNLWRDTLAQAGITHKRTRAYRPQTNGKVERYNRTLLDEWAYAQAYRSETERRETLPRWLHTYNHHRGHTALKGQPPASRVPNLTGQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY68</accession>
    <name>A0A7W7WY68_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine synthase B</fullName>
            <ecNumber evidence="6">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="9"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="33906" checksum="17F15832F4B33C06" modified="2021-06-02" version="1">MTRYESLLDAVGGTPLVGLPRLSPSKDVRLWAKLEDRNPTGSIKDRPVLMMIEEAERSGVLTPGCTILEPTSGNTGIALAMAAKLKGYGLVCVMPENTSTERKQLLQAYGARIVFSPAAGGSNQAVARAKELAEQNPDWVMLYQYGNPANAGAHYHGTGPELLKDLPTITHFVAGLGTTGTLVGTGRYLREQKPDVQIIAAEPRYGELVYGLRNLDEGFVPELYDETVLTGRYSVGSYDALRRTRQLLEVEGIFAGISTGAILHAALAAAEKAVTRNEPADVAFVVADAGWKYLSTGAYAGTLDEAAERLDGHLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT9</accession>
    <name>A0A7W7WYT9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="12742" checksum="BBF768BD5258F14D" modified="2021-06-02" version="1">MNANPNGVDELRTEDAATTPNGDVPNEDNPHDPLADLPVDERTLDPLAEAEVVLATAELATAGLATAVPERLLATEGEDEPVGPTGSHQTNGGQGGSGTGGGTPREAPTGSHQGDGTNGSHQTNTGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV2</accession>
    <name>A0A7W7WYV2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031055829" evidence="1">
        <location>
            <begin position="22"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="527" mass="57379" checksum="F2342D6FE482E4F6" modified="2021-06-02" version="1">MKRLLALLLAMATITAGSAAATSGDGRYDHPRTGWMNAVLHDGFSPVDRTPIEKALRHVRALPNFPGAVTLLAHDGVIVAEEAAGWAVRYADAKTELPPDRRVPMTVDTVFDLASISKLFTSIVVMRQYELGRIDLDAAVSRYLPEFGVNGKADITVKQLLTHTSGLVDWLPLWSDYPDVPARIKAVMDTRPTDAPGTGYRYSDLNLITLGLLAERVSGTTLDVLVDRTIATPLGLKDTGYRPKDKSRTAATEFQAGRGMVRGEVHDENAWSLGGVAGHSGVFSTARELATVGQMILNGGRYRGVEILERDTVTLMLTDFNSRFPGDAHGLGFELDQNWYMGALSSPGTAGHTGFSGTSLVLDPLSGSIAVLLTNRVHPDRNRGSINPSRRAVADGLAQALAVRPVAGKTSWAAERDGGTLTTRVLPAQRHRLEFAAFVDLAAGEEVAVQAFTDDQWRDLRKLTGYGTRRWQRIVVEAEATRFRWRYTAGTGPYGRGVHVDAVRVTDRRGQVLDSELSPDGWRIADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYZ8</accession>
    <name>A0A7W7WYZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="48" mass="5378" checksum="CCB65278621CB0F9" modified="2021-06-02" version="1">MASTELMELGGAITQSSTAREHDQPVAEQRAEALLERVEDMIHRRELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ97</accession>
    <name>A0A7W7WZ97_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ORF">F4559_005927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="213"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4968568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="321" mass="32930" checksum="51733FE245B7B4A7" modified="2021-06-02" version="1">MLAVVPPPVTVRVPAKVNLHLAVGDQRDDGYHDLVTIFQALSLTDEVTVAVADDPGVEVSGEGADVVPTGPSNLAWRAVRVLAEHAGRDADDPKVRVVIKKSIPVAGGMAGGSADAAATLIGLAALWRLEITKDELAGLAATIGADVPFALYGGTALGTDRGDRIVPVLARHQFHWVLAFDKGGLSTPEVFGELDRLRAEGDPPRVGEAEAVLEGLASGDPRQLALLLGNDLQAAAVSLRPNLRRTLRAGVNAGALAGMVSGSGPTCAFLCTDGDAAVRVAAELAGAGVCRTVRVAQGPVHGARVVGTEEAPRPTPPEVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZD5</accession>
    <name>A0A7W7WZD5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="456" mass="48119" checksum="63BAB2B9F2FACC3A" modified="2021-06-02" version="1">MAQTDEPGLKRAIGPKLLLFFVVGDILGTGIYALTGNVAGKIGGALWLPFLIAFAVAFLTAFSYLELVGKYPRAAGAALYTNRAFKIQFLTFMVAFAVMSSGITSASSAALAFGKTYLQSVIREFFSDTFTVSATLVAILFIVGLALVNFRGVSESVKANVVLTCIELSGLLIVIAIGLSAVLNGDGDASRLTQIEPANGQSALLAVTSATALAFFAMVGFEDSVNMAEECQDPVRIFPRAVLWGMVVAAVIYVLVAVTSSLLIPADELAGAKSSALLRVVEVGAPGFPLWVFSLIGLFAVVNSALINMLMASRLVYGMANERIIPKAFGVVHPLRRTPWVAIVFTSGVAIALVTTADIEKLGGTTALLLLVVFAIVNVAVLVLRKDTVAHKHFRAPTWAPVLGVLTCVYLASPLSGRPAADYRIALYLLGAGAVLWLVNRFAGGRKKVDAEKLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZS6</accession>
    <name>A0A7W7WZS6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretory pathway pseudopilin PulG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="254" mass="25869" checksum="A54A4DAA83CF7E29" modified="2021-06-02" version="1">MTEKNTGNDNSGNAVPPESGPTPPASAGVPDPTGQVGAADVPGSGAAGPSGRSGPDDTPTTTSPAAPPPYRPATAPEPPRPDGRGRVRNQESGRTKPKPPSLAVQRAREQAVREEQERQLALEAEQARKRKTRKRLLIGGGVAVGVVGVVAIWYAASSPDDVEAQCTKDDVVVDDQYCDPSYASTHGGYTSGGFIYIGGSSYRYHYGGTSTPVGSKVSGGSYTIPKGSNVTTKSGTVVQRGGFGVSGGSKSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X003</accession>
    <name>A0A7W7X003_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynamin_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="PTHR10465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin_N" evidence="4">
        <location>
            <begin position="47"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="504" mass="53174" checksum="92F68CF51E5F9984" modified="2021-06-02" version="1">MTAPAPPPGPLSAAVANLCAGLRPQVSPATAAGFTEVLRRLSAPLQVAVAGRIKSGKSTLVNALIGRRVAPTDVGECTRLVTRFQYGTVDRIEVVFTDGRKQVLPFDQDGMIPASLGVDVDRVSHVEAYLTNAVLQDLTVIDTPGLGSLDAASVARTEALLGGDLDPVSRSAVAGAEAVLYVVTQGVRYDDQQALAAFTAATAGREAGPVNAIAVLNKADTIAAETVEGADGDTWKAAMILAERQADTLRPRVADVLPVIGLLAESAESGGFTSSDADGLRRLAELDEATRETILLSADLFTTWECDVPIGTRTRLLEKLDLHGVRVALAAIDAEPAITAGALRRCLLDASGLDAVRGKLNSVFRSRADGIKAAAALASVTALAAASGDPNERRRVHDAIEVLLTKPEAHQLRLLEALTLVASGAVAMPLDLVEEVLRFGSSPDPGEQLGLRGRPHPELLAYALERAGWWRSFASFGATPAQSRVAHVVHRAYFLIWQQLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SX96</accession>
    <name>A0A7W7SX96_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-amino-4-deoxychorismate lyase</fullName>
            <ecNumber evidence="1">4.1.3.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.38" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4962649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="279" mass="29459" checksum="23200488B9C18932" modified="2021-06-02" version="1">MRVLALPDGTLADPDQPFVRADDLGLLRGDGVFETVLVVDGKPREWAGHLDRLVRSAAMLDLEPPDLAGVERAGRAVIDHWTGGELALRLVCTRGAEGGDGTPTVFALGSEVGAKARRQRVDGVSAIALDRGFDADLAERAPWLLLGAKSLSYAVNMAALREAERRGADDVVFTTPSGEVLEGPTSTLVLVRGRTLRTPPSALGILPGTTQAALFEVAAGAGWTTEVGRVDVADLYDADAVLLASSVRLIARVHTLDGKSLPDSSEVHAELAACYESRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXH4</accession>
    <name>A0A7W7SXH4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7187" checksum="1C2ED9E242786BAE" modified="2021-06-02" version="1">MAKEVATMLYLLAVIGALTIAVLLWRAFGPDRVETAPTRFVAPDDDPEFLRKLGEQSRKKPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXI8</accession>
    <name>A0A7W7SXI8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MinD-like ATPase involved in chromosome partitioning or flagellar assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="246"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="489" mass="50756" checksum="7A39BE063C53980C" modified="2021-06-02" version="1">MNENRNVDPRTVYLDPLPVEGSPAGFPTAGGAYPAAGQADPQQVAGTSGAYPVAGQNGPNQAGGGASGAYPVAGQSGPHPVGGGPSGAYPVAGQSGPYQVGGGPSGAYPVAGQSGPYQVGGGASGAYPVAGQSGSHPVAGQSGPYAVGGQSGPHPAQQHQHQQSYPGGFPNNFPQSVQPQRPPTTAHDVSSQQLIKKSKRPPQSGWRKAVHSITGGLVNLGESPADLRRRELISRINQPLRGCYKIAMLSLKGGVGKTTTTTTLGSTFSSLRGDRVIAVDANPDRGTLALKVPRETTATVRHLIRDASRITKYSDVRAYTSQSPSRLEVLASEQDPAASEAFSDQDYLRTVGLLELFYNIVLTDCGTGLMHSAMRGVLDQANSLVLVSSGSVDGAQTSAATLDWLEAHGYRDLVARSVAVINSVRPGSGKVDLDKLSAHFAQRCRAVVRIPFDAHLEEGAEIELDKLAPDTRLALLELAATVADDFPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY39</accession>
    <name>A0A7W7SY39_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="72" mass="8005" checksum="A0EB8F142F25EFCF" modified="2021-06-02" version="1">MTAIQHHAGERLLTPGEVANLFRVDPKTVTRWATAGRIGSIRTPGGHRRFRESEVQALLSQLTTEATEPVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYU5</accession>
    <name>A0A7W7SYU5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000831</name>
        <name evidence="4" type="ORF">F4559_001380</name>
        <name evidence="5" type="ORF">F4559_006175</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="2">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="487" mass="54292" checksum="C1B791D30D8F478B" modified="2021-06-02" version="1">MISVHHLDPRSALGALSGFRREFHRCLTRRADGLFELADAVLCADGPVRTLVGLSLAPEHRRGHGGLYDAVNNGRIEVDRLRDAPAGTPLPRAADGRLVLAVDVSPWLRPDGATCPDRTFCHVYGRGRGEHRMIPGWPYSFVAALETGGTSWTALLDAVRLPPGADLAAVTAAQVRGVVQRLIAADQWRRGDPEILVVFDAGYDAPRIARLLEDLPVRVLGRMRSDRVLRRPGPPRVHNPLGGRFRKHGGEFVFGDPATWGAEDVLTRTDTRLYGTATAQAWNRLHPRLTRRAAWIDHSGPLPIVEGTVIRLTVERLPSGGVNKPVWLWCSDPDSGPVEVDRWWRAFLRRFDIEHTFRLLKQTLGWTRPRLRDPEAADRWTWLILAVHAQLRLARPLVADLRHPWERPAEPARLTPTRVRRGFRNLHMKIARPAAAPKPVRPGPGRPPGSKNRATAPRFDVGLVLATGRAHTRPAHHKKGTKPRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYX8</accession>
    <name>A0A7W7SYX8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="77" mass="8361" checksum="272C290DD6B1AD30" modified="2021-06-02" version="1">MVATPALRNYARTLWTGCETTLAHVIAEQTGRAADDLSLRLLVRYVLEIPDLAGTEPDPTAALDTAFAHLGRGWPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ78</accession>
    <name>A0A7W7SZ78_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025680">
        <property type="entry name" value="DddI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14430">
        <property type="entry name" value="Imm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="147" mass="15853" checksum="9F51082D7DCAC4D0" modified="2021-06-02" version="1">MALIAAYDPDGPVAITTVAELDAVVDQVVGWGHRAVVELKIARPVEPRGRQLSLTVGIHGAAGLGTLIYSSPDGVWFGKATPGPEWAEVDERVLYFLMSADTEYPPESEIPLDVVRRAAQEYWHGGGSRPGGVGWCAPPPWYPTAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ93</accession>
    <name>A0A7W7SZ93_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thump_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="309"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="383" mass="41242" checksum="A22FC70A364641D3" modified="2021-06-02" version="1">MGYAFSLDDVAYLRSDAGCAALSAVADLPLTPESRLADVAAARRVAPEKFAAVLETALLRRRAVGRVDLVDGLYTADALQQATASAVARHRASRFAGRVVHDVTCSVGADLSALPVGSIGSDLDPVRLAMAAHNNPGRVLLRADALRPVSRGTAVLADPARRDSGGRRTWRPADFLPPLDELAAAYRDRDLAVKCAPGVDFAVAPWADEVELVSLDGSVREACLWTRGLATPGVTRRATVLRSEGPQWTVTDADPDDCPVTDPDEWLIDPDGAVVRAGLVRHYAARFGLAQVDERIAYLTGPTPPPGIRAFRVVEHGHYTEKALRAVLKAHDVGRLEILVRGLDIDPNTLRRRLKPTGTAEYSVVLTRIGRRPTYLLAHATRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZG4</accession>
    <name>A0A7W7SZG4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030701795" description="PHB domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="67"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="298" mass="31816" checksum="01927CD6C2654235" modified="2021-06-02" version="1">MIRPLTLAVLLFLAAAVLLLSGCSIANTTASEVALQYGGGPFDSRVFVQCVPNGTREVNDVADDHFYYPAGQRDFTFGPDQGLDSAPLTSTTGDAQEISVSGTVKFTVNTDCSEFVDPSGKRWPGGKLQMFHELIAAKYDAAPTDGGESMPNGWKTLLRNYIGAAVDRATDNEALKYGWQDLYTDTAKKAQWEKDVLAQLPAILSTLTQGVDLIQINAVLLQKPGIQPALVSGLTDKQAAELRNQAAEVDKKAAENFPGGLAGYQAYQQQQAINQAIKDGKVQVLPVPQGSPVIVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZT0</accession>
    <name>A0A7W7SZT0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding FadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_001341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4963982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24371" checksum="CB1B049CDFFBC829" modified="2021-06-02" version="1">MATTRRAGLVDQVIDQMRAAIAGGEWPVGQRIPPEPELVTALGVGRNTVREAVRALSHAGLLEVRQGDGTFVRATSELSGAVRRLCGSELRDVLQVRRTLEVEGARLAATRRTDEEYRRLAVLLTERDEALVAKQWDRLVERDAAFHVLLVQCSHNTLLAELYQGLTEAVRASITATVDKEHEEEQVSHAGLLDAIRDRDPVRAAAEAGGFLEELLERHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T092</accession>
    <name>A0A7W7T092_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="9" type="ORF">F4559_001285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="255"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="337"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="399"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="447" mass="46412" checksum="51ECCC0286FD33E7" modified="2021-06-02" version="1">MSSTTLIWIIVAVAVLLAVALVTGVVLSRKRRISLAERKGDEPVKGAYQAGGGISLAGGRTDATTAVPDTTPDTTPDTTSDAVPDEVPDPTPEPVEHPVADRTEVDGQPGVGDDAAVPRDSVKRGIVEVDLPDEASEIEEIEPTAGRLERLRGRLARSRSTFGQGLLGLLGAGDLDEDSWTDIEDTLLVADLGAGITDQIVTALRAQLVSRGVRTSEQARALLKDVLTESLYPEMDRSVRALPHSGKPAVVLVVGVNGVGKTTTTGKLARVLVADGRTVLLGAADTFRAAAADQLETWGSRVGASTVRGAEGADPASVAFEAVKQGVTAGVDTVLVDTAGRLHTKTGLMDELGKVKRVVEKQAEVDEVLLVLDATTGQNGLTQARVFAEVVNVTGIVLTKLDGTAKGGIVFQVQRELGVPVKLVGLGEGADDLAPFEPAAFVDALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T099</accession>
    <name>A0A7W7T099_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-70 factor (Sigma-E family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001582</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014325">
        <property type="entry name" value="RNA_pol_sigma-E_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02983">
        <property type="entry name" value="SigE-fam_strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4964223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="167" mass="18938" checksum="EF9E464E9299D5A6" modified="2021-06-02" version="1">MSDRDAAFAEYFAARSEAMRGTAYLLCGDWHRAEDLVQATFTKLFVAWRRIQRHEALDAYTRRTLVRTFVSELRRGWFRKERVSDSPVDSATAGAGSTEDRIVLLAALAKVPPRQRAVLVLRYWEDLSVEETARAMGCSEGTVKSQAARGLQTLRGLVTPQREEMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Y6</accession>
    <name>A0A7W7T0Y6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase EntD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009366">
        <property type="term" value="C:enterobactin synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009239">
        <property type="term" value="P:enterobactin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041354">
        <property type="entry name" value="4PPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003542">
        <property type="entry name" value="Enbac_synth_compD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38096">
        <property type="entry name" value="PTHR38096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17837">
        <property type="entry name" value="4PPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01399">
        <property type="entry name" value="ENTSNTHTASED"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4PPT_N" evidence="3">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="103"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="219" mass="23668" checksum="33604F1C30887651" modified="2021-06-02" version="1">MIIGDLLPPPVVAVDFFGDPEDAVLLPEEEEHVAKAVDKRRREFTTGRHLARTALGRLGFGPVPLLPGEKRAPRWPEGVVGSITHCKGYRAAAVGRTSQVWTIGIDAEPNEPTPDGVLGAIAVPGELAHLPRLRATGDHVAWDRLLFSAKESVYKAWFPLTGLWLGFEDAEVIVDPDGTFTARVLIDAPVVDGVRVDGFTGRWLARDGFVVSAIAVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T141</accession>
    <name>A0A7W7T141_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="140" mass="15471" checksum="52DCFFC2F9DD7351" modified="2021-06-02" version="1">MRFMVIVKANADSEAGVMPSDEVLREMGAFNEELVKAGVLLAADGLAPSREGARVYFSGDKRTVVDGPFAETKELVAGFWLLELKSLEEAVEWIKRVPNPTGEESQIEIRRIYSLEDFAAAAPDVLAQEEALRTQVEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1F4</accession>
    <name>A0A7W7T1F4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">F4559_002157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="33251" checksum="DCEC03724F188909" modified="2021-06-02" version="1">MAFPVVLLASPRSFCAGVERAVEIVERLLDQRGGPVHVRKQIVHNVHVVADLEARGAVFVDELDAVPDGATVVFSAHGVSPAVRAEARRRDLEVVDATCPLVTKVHAEARRFAARGDTVVLIGHADHEEVEGTFGEAPESTVVVATPEEVAALEVPDPDRVSYLTQTTLAVDEAAEVVAALRARFPRLKGPSSDDICYATTNRQEAVREVAGDADLVLVVGSANSSNSVRLVELARRQGVPAHLIDDASAIDPEWLRDVQVVGLSAGASAPPRLVDDVIAALGAWDVQVRETTRETIRFTLPGIVRRGDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1G0</accession>
    <name>A0A7W7T1G0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="79" mass="9160" checksum="C88FF49F398C010E" modified="2021-06-02" version="1">MLEFGEDNDVGYDWWVAANPNQFVIDAEPSFDITTMVLHRVVCRTGIARDHVRICGTRRELETRYPRVRACADCMAGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1P2</accession>
    <name>A0A7W7T1P2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS30 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="153"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="368" mass="41071" checksum="56F4F161F3E59456" modified="2021-06-02" version="1">MIADPLRAGRGVRAIADEPGRPPSTISREVKRNRHPGPGDHRPHAARERADARRPRPGMGKIAARPELRDLVQGMPDDRCGPRQISRRLRRDHPDRPEPHVTHETIYQALYLQGRGELRRELARALRTGRTVRKPRRAPDRRRPRFTHPMVMISERPAEAEDRAVPGHREGDLVIGGGGTSAIGTLVERATRYVLPVHLPARHDAETVRDGLITTVSTLPAHLRQSLTWDQGSEMGRHHEFGVATGMPVHFCDPHSPRQRGSNENTNGLLRRYFPKGGDLSVHTADEPAAVAAQLNRRPRKTLGWDTPAERLTTLLTEASRPPVLQRPLEFAVRTRGLSGRTDYFASLSSSSMSLGWSPRSRVSTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1S9</accession>
    <name>A0A7W7T1S9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed RNA polymerase specialized sigma24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="168" mass="19173" checksum="036A7685ECB559B0" modified="2021-06-02" version="1">MTGESVPLTPDQAWQRCVRRRDRLRRTVERFGLTEHADDVVHDVFVSVMGKPVLHRDGFDALLDTAVWRRCLAVARKEDRRRRLVHEIGSVPVVGDHSDSVVDRIHAEWLLRGGGVLVRSEARLLALTGLGYSRGEIARRVGRPVVEIDRVIRALRRRMRYRLGGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1T6</accession>
    <name>A0A7W7T1T6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem II stability/assembly factor-like uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030611195" evidence="1">
        <location>
            <begin position="25"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="344" mass="35907" checksum="AFD6BAD63755E629" modified="2021-06-02" version="1">MKSLLLAAALVVAVVFSGVAPATAGHEPTWQLKPTGVTAQFRGLSAVDHRVAWVAGSEGTVLRTTDGGASWASVGPPDTSTLEFRDVEAFDARTAVVLSIGPGAASRIYRTSDGGKTWALTFQNAEPAAFYDCVAFFDRFRGLAMSDPVDGKFRVQLTRDGGRTWRQVPEENFPPALPGEAGFAASGQCVATAGRSDAWIATGGGAKARVLHSDDGGRHWTASDTPLFSSVSAGVFAVAFRTPDQGLAIGGDYANPTGRVANLALSRDGGERWKAVESGPVGYRSGVAWHRGSVIAVGPKGSDVSRDGGRTWRSIDSGSFDTVDCADVCWASGEKGRVAVLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1V1</accession>
    <name>A0A7W7T1V1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="424" mass="45191" checksum="24C228B8AE6B2DCB" modified="2021-06-02" version="1">MDTDLISRRLSALAHDHRVPGAQLAVSHAGETWHREVNLTPGAAVPIGSITKTCTATVAMALVSDGDLELDAPLGDHLPEAPDALTLRHLLSHTGGLPSDQEDVRATSLRRYVRETVRSLDPLHRPGAGFSYSNIGYVLVGHLIEIATGMTWWEAMEEVLLRPLGLRAHFTVGRDTDRSIASGHAVNAATGRVVPVRQSLAVVDAPAGALAASASDLVAFGRMLAGGEPHLVSASDLALMRTPVDDAEPFGMADGWGLGLALYERDGSTWVGHDGTADGTSCHLRIDPESGTVVALTTTGSTGFALWRDLVGDLSDAGLPVADYDPLRGMALPIPPPRDCAGHFRNGDTEYRVRPAGEEVLELTVDGEPFADLSLFDNLVFAMRDSDTGDTSQTGRFLRDPRGGGIEWIQIGGRLARRQVREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T232</accession>
    <name>A0A7W7T232_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrroloquinoline quinone (PQQ) biosynthesis protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PTHR40279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="237" mass="26506" checksum="C66C723F1D6E17B3" modified="2021-06-02" version="1">MTTRYETATAEVAAELALVEEHPFVRTILDGKLTKPVYAAYLRESYHLVHETPFFLSAAASYSRDEGWLQDWFLDLAIDERHHDRLCVHDLRNLGLEPADFLGSRPGLGTWTMVSQNHYLATKKDPAGIIGFAAATEGLGAELAPKAAKALVQYPFTHDALSFLKVHSTEDVEHIEEVKKAFERVAESDERYELMVEIWKFTLRAYAQLFTDSVERGEHDAQLAALLGEPATTAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2C0</accession>
    <name>A0A7W7T2C0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">F4559_002607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4965248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="33935" checksum="5EFDD2C2E20DA5CF" modified="2021-06-02" version="1">MRFRSDPTTIKGSIAPVVTPFTATGELDTDSLRNLVRWQKEQGSHGISIGGSTGEPLVQSLDERKTALRVVADEIGDEIPFLPGTGASTLESTLELTGYAKDLGADLALVITPYYSRPTQEGLFQWYHTVANEYPDLPIVVYNVPSRTAVDIAPETVARLRKANDNIVGIKETTKDFEHFSHVLHQCGRDFLMWSGIELLCLPLLAIGGRGFVSALANLAPAAVAKMYELYEAGDHQGAIDLHYRLHPLVDLLFVETNPAPAKHVLADLGHISSGYVRPPLVEPTPAGLEKINKLRAQAEDLLLPAKAKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2U8</accession>
    <name>A0A7W7T2U8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IclR family pca regulon transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046278">
        <property type="term" value="P:3,4-dihydroxybenzoate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012794">
        <property type="entry name" value="PcaR_PcaU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02431">
        <property type="entry name" value="pcaR_pcaU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="251" mass="26629" checksum="94242AE5B6BCFDE2" modified="2021-06-02" version="1">MSVEHVRSLERGLAVIKAFGADAPALTLTEVAGRTGLTRAAARRFLLTLCELGYVRADGRHFSLTARVLDLGYAYLSGMALPDVAQPHLERLSARVGESCSVSVLDGVDVVYVARCAVSRIMTVSITVGTRFPAHATSMGHVLLAGLDPDDQADRLASTDFTSFTGHTVTSAEALRAELATVRTRGWALADQELEEGLRSVAAPVRDRAGRVVAAVNVSTHAARTTLERARAELVPPLLDCAGLISADLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T311</accession>
    <name>A0A7W7T311_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="50" mass="5580" checksum="77AA019C1EC236CB" modified="2021-06-02" version="1">MHENDSRRALANPRRTRLAADWTAQSVSTATDPRPAPHPEPEARSTDDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T318</accession>
    <name>A0A7W7T318_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="82" mass="9381" checksum="6CD6E992F7E979D1" modified="2021-06-02" version="1">MVNGILWRMRTGAPWRDLPERYGPWKTCYERYRRWAADGTWARLKRQVQGRAEAAGDIDRDAQADSTVVRAHQHAAGARKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T360</accession>
    <name>A0A7W7T360_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-2 type transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="312" mass="33801" checksum="63F93C0FA7F94F1B" modified="2021-06-02" version="1">MSTQQPPIVVRDLGRSFRSDGGRRALAGVDLTVDRGEVHGLLGPNGAGKTTLCRVLSTVLLPTSGYALVDGHDVVTQTAAVRRLIGVVFGGERGLYARLTARQNLRFWAALYRVPRTRVDPLLDRVGLTERADERVQTYSRGMKQRLHLARGLIADPSVLILDEPTTGMDPVAAREFRVLVERLRAERRTVLLTTHDMAEAEALCDRVSILDGGRLIATEQPAAIGRWISRYEQVEAQAVPAAVAAGLEHLPGVAAVRSPRPGTVLVETSEEGAVAVVLRYLLDAGVSTVATTPPSLEQVYLRVIGDRGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3I5</accession>
    <name>A0A7W7T3I5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="11" type="ORF">F4559_003200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="229"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4965841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="536" mass="56759" checksum="02757D4310A1EE87" modified="2021-06-02" version="1">MVAPPVAAPEPAPAIPRARRGFLRGVLPRLVLAAAGGFLLYLSVPPRTTWWLAPVAFAVLGVLLHGRRARAGFGLGLVWGLGFLTPLLRWTGEFVGLVAWLPLALVCALLVAVGTAAMARVSTLPGGPVWMALVWVADEALRSTVPFDGFPWPRVAFGQPEGWYLPLASVGGTPLIAFAVAVTGFGIAHLGRSWRLGVPLAVVPVLAGLALTPLVHTDATEGTAVIAAIQGNVPRAGLDFNSQRRAVLDNHVNRTLALAEDVKAGKVPRPDVVVWPENSSDIDPFRNADAAARIDQAARAIKAPIAVGAVVVDRGDGRPRNTVVLWDPDRGPIDTYTKRQLQPFGETMPYRSFFRIFSSTVDRAGTFLPGTDPKGFEVGKVRLAIDTCYEVAFDSVVRDSITAGANIIAIPTNNATFGYNEMTYQQLAMSRVRAVEHGKAVVVAATSGVSAIVQPDGSVTARTGMFTPDALVAELPLRGEATLATRLGPWPEWVMTALALGALAFSLTLTRRRARPTTPEPGVGEEDTDGGPAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3P5</accession>
    <name>A0A7W7T3P5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4965472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="341" mass="37278" checksum="7F853CDCA9CF1915" modified="2021-06-02" version="1">MNGDALHSIGELARRTGLTVKAIRFYSDRGIVPPGDRSPAGHRRYDADAVARLDLVRTLRDLGVDLATIRKVVDREIPLAEVAAAHAEALAVRIRVLRSRRAVLTTAARRASTPEEMELMHRLAKLSDDGRRRLVDDFLQAAFGGVAADPAFVGIMRSLTPELPDDPEQDQVQAWVELAELSQDPDFRESMRRVADSLATERAHVDGVYRDPVAAVREQAGPALAAGVDPASPDADPVVAAVTAHYADLRGEADDHDLRRRLLTRFEIANDPRRERYLRLLAVVNGWRAPESATPALEWFIRALRVRTAGLSSAPSPLSRTDGTRTAGTVPAVESVPDPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3T4</accession>
    <name>A0A7W7T3T4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="17645" checksum="91A5E21B6C64924E" modified="2021-06-02" version="1">MIIRTSRTEDLPEVLALTITVFGPFYEDSYRPRVGDRVFLDRHGDWRADYARHVAAVHDPGQGRHAAVAHLDDRIAGYVAWVVHEADRHGEIDILAVSPDHRRRGVGRALLDHAQAHLKSAGVTVVSIGTGGDAFHAPARALYESLGHTPFPTVNYTKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T458</accession>
    <name>A0A7W7T458_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35824" checksum="BFF2F2CC8AFD59AE" modified="2021-06-02" version="1">MTTPVLTDWLLDSDPALRWQVERDLLGSPPQVWRDTRARVATEGFGARLLAVQDPDGQWAGGAFFPRDREGPEKVQPWMATTWSLNSLREWGLDAAVLAGTAGLLAENSRWEYENLPYWGGEVDCCINGWTLANGVWLGADVEGVATWFVEHRLPDGGWNCDWVEGSTRSSFASTLNALKGLLAHEIATGGTAASRAARRAGEEYLLRRGLFRRLTTGAQVGPWATTFAYPFRWQYSVLRAADHFREAAAVDGTPPDPRLADAVELIRATRRSDGTWLQEARHPGRVWFEVDVAPGEPSKWLTLVGTRVVEWWDSRPLVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T460</accession>
    <name>A0A7W7T460_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">F4559_003597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007895">
        <property type="entry name" value="MASE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05231">
        <property type="entry name" value="MASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="440"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4966238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="682" mass="71566" checksum="57E7F0DEC7300F98" modified="2021-06-02" version="1">MGDDVRGRMTALARTAGFAALFVVATAAGRLTVLDATNLSLVWPAAGVAVLWFAAQRRSPTLWVDVAAFAAITVVVNLATGASPGQAGVFVIANLLQAGLFVILVARVRPVVFERGLRSLPDLWTVLAATVVATTAGALVGPLGVWLVTGHYSLITTAVWLSRNIAGIVLVGTLGLTLLRSGPVRNVGECVAVTACSGVVYVVAFTADEGLPVASLLISLTVWAGARLSARFVTLHTAGLAMIAVLFTLHGQGPFSYVDSNAGRALIVQLFVTTVAMIGLALALGREERQALLDELGEEKENAAQRATLNRAIIDSMTEGLTVVDSTGRITLGNPSAVRLLGGKIGLDGIAAGSAYYGMFHLDGTPMSDAEMPHARLAAGETVQEMDVLIRNEGVPEGRILQLRATALPEPGGGQSTVLVYHDVTAERRHRDELVAFAGVVAHDLLNPLTAVDGWSDIARESLYHANVSEASIALTRVGRAAGRMRTLINDLLSYTTARDAPLKPVPVDLTALVADIAAGRADAAVAAGAPVPKFAGRTLEPVLADAVLVRQLMENLIGNAIKYTAPGVVPEIVVTTHRRGGRISVAVVDNGIGIPPGQHDRIFATFHRAHTGTNYTGTGLGLAICRRIVERHGSTIVATDNPTGGSRFAFTLPAVRPEDTYTPPLPRTEQPPNSLSRRQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T486</accession>
    <name>A0A7W7T486_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4034 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025115">
        <property type="entry name" value="DUF4034"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13226">
        <property type="entry name" value="DUF4034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4034" evidence="1">
        <location>
            <begin position="109"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="367" mass="41140" checksum="541A7D1A3DCFC460" modified="2021-06-02" version="1">MGLLTVLTKPRFTLAMISLSREAKRLGKPWDDYVSGAALRARMVTLRHPSRWGLPAEWDITDEPFVTDPDLAAALAARRKGDWKPVARVLESIGTDWARRAHAVDLLAAHTWSDRTSWLDKWLTAEPESPDAAVVRLGWLVAHAWVLRGADRAHNTSAEQFAGFHRVLRTAVEQAKRASALAPDDPTPRQHFLTIARGLGFPPARFPELWADLLRCDPSHRGGHRHALQYWRPHWYGSYPKMFAFADEAAAKSPALASVRIVAAVEACEDHPDTWRAPELAQAVDTTLAWVDGDGDGADSPTVREDRALLAVALVELRRYDEALAQFRVLDRNADASVWGRLWGDERMGFTYTRARAYQHVRPTTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4D0</accession>
    <name>A0A7W7T4D0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.336</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="315"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="441" mass="47403" checksum="88D5C871106725C7" modified="2021-06-02" version="1">MTEELPELRRVGIIGMGYVGLTLAAAMADRGYEVHGVDTQSAVLDSLSRGRPHIFEPGVEEVFGEWVGRRIFLSPDLPDGGVDAAIICVSTPVNEGDHEPYLGNLAAAAEHIAKRCSPDTLIVVRSTVPVGATRAVVLPRLLDAWGSARVVMAPERTIQGQALRELVELPQVVGGLDDESLELGLKLFGGLSKQLVPVSNLETAELVKLTNNCHTDVIYSFGNEVARLTESLGLDPLEVIRATNLDYPRPDIAKPGYVGGGCLSKDPYIMLAGAERSGYELPLIRAARRINEDLPVHVAERLVDLLGDPAGRTVFVLGWAYKGWPPTDDMRGTPIASMTPIFEAAGVKVVGHDPLVTADVIKRYGGEPVDLETGFAQADAVLVITDHPQYRALDVDALLTGSAVKLVYDSWRVLDGDKVEGHGIRYTGLGFEPAAEPEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4D7</accession>
    <name>A0A7W7T4D7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding HxlR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="16834" checksum="F35A365F9F53A729" modified="2021-06-02" version="1">MQRTDFGSMACSIARTLDVIGEPWSPLILRDVWVGLTRFEQLQADLGISRKVLTERLNHLVDRGVLDRRPYDRRPRYEYVLTDRGTELVDVLMAMARWGDRWLAGEAGPPVLYRHHACGEVATVDPRCAHCGEPMHADNVDLLPGPGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4X6</accession>
    <name>A0A7W7T4X6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative anti-sigma-YlaC factor YlaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="240" mass="24953" checksum="8928E68607961ADB" modified="2021-06-02" version="1">MECETCREALSARLDGEAEPVPAADVDAHLEGCAACRSWQDEAMALTRSLRVRAASATPDLAAVVVARGIRRGFGFARPALGAVGVAQLLLGGVQLFGVFGASDVHGAGVHGVAGGHLFNEATAWNLALGLGILCAAWWPRVAGGLLPVLGGFLAVLAPFSVYDLSSGHASATRVLSHVILVVGLVLLIVVHRGRRGPDRRGLPVEDRVVDGVAEVRGGGAERSTRRARSRLRPVGRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T522</accession>
    <name>A0A7W7T522_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="617" mass="65424" checksum="B161CC42C269BB63" modified="2021-06-02" version="1">MRWIAGRHGPGTGWVPVGDKVEGCGGLWSAEWPPARVRTVGDGNRRMAVFGDCAARAVCLERGLRAAVAGDLAAVTRWPGSYLVVLRDADRTVVVGDLPGMFPVHWTTQAATTWWSTSALLLVADRGVPPVEAVDPPVLAAQLAFGQPDLPGTRSVLRGVRRVPTGHALMIDEHGPVPVRHEPIDPAPSDRSRAAPALSGALRAAVESRLDGRPVSADLAGVDSTTLAVLAAERGPVLAVTFADDRLRDDDLAHARRTAAVVAALDHRVARDPAAVYYAGLGDPAGLPLTDAPNAYTATLAVKDAVFDTVTAAHGDGGVHFTGSAGDGVLGAGPDHLADLLRARRYGPFAAGLLGHARLRAESPWTLLARVRPAATMAADSWRATARTLHRPATRWEPDSRRPWAWSPPGTVADWLPPPARHDLADLLDTAADQAASATWVPDRLEHWTTRQRLAQLAVDVTGRQETARTRHGVEVAAPYPDSEVVRVCAAVPGRLRGNPHRYKPLLQAAFTGVVPDHVLHRATKGGFDAIAYRGLRDHGPTLLALLGGDSRLAALGLLDPVPATAMLDRACTGRAAAMGALHQVIAAELWLRRLDHAPGRPQWTEQTPEVACAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5J5</accession>
    <name>A0A7W7T5J5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="311" mass="32746" checksum="DF5D4D48DB95BD7E" modified="2021-06-02" version="1">MDYDVVVVGGGAAGLSGALMLARARRSVLVVDAGAPRNAPADGVHGLLARDGVPPAELLAVGREEVRRYGGLVERGEVVDVRRVDDGFVVDRGDVTTVRARRVLVATGLVDELPDVSGLRERWGRDVVHCPYCHGWEVRDRAIGVVATGPMAVHQVALFRQWSADVTYFAHVTSPLPDVQAERLAARGIRVVVGEVAALEVAADRLVGVRLVDGSVVARDAVAVAPRMKVRADFLKSLDLTAVEHPSGAGDHIPVDEFGRTAVSGVWAAGNVTNPMAQVGAAAAAAADAAARLNADLVEEDTDRAVAAYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M2</accession>
    <name>A0A7W7T5M2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type nitrate/sulfonate/bicarbonate transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030861124" evidence="1">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="335" mass="35660" checksum="5566090B64DA48E1" modified="2021-06-02" version="1">MTSTRRDFLALSLLGLATAAVGCGTAAGGGGEETKTLRYQGSVGQVTPAELAADLGYLGDIKLEWVGNTISGPQDIQSAATGQIEFGGAFNGAVVKLAAAGAPIQAVIGYYGVDKDAYSGFFVAEDSPIRSPRDLIGKKVGMNTLGAHSEAMLGIYLQRAGLSREEIKGVEALVVPPVNTEQSLRQKQIDVGVLGGVFRDKALAAGGIRPLFTDFELQGAFTAGSYVLTKKFIQQNPNTVRTFVTGVGKALDWTRATPRDQVVARFTEIVKKRGRNEDTATLQLWKSFGVAGTGGRLDEKDFSIWLDWLSGRDEVKKDSVKTAEIFTNDFNGAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5M4</accession>
    <name>A0A7W7T5M4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030709775" evidence="2">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="32764" checksum="443A1D4F8571A710" modified="2021-06-02" version="1">MSRQVLVCAVAVVVGATACTSGEQKAEPPGLADRGATMTTAKPTRQDLSSRISLSGKVAMNPVFGLVAPVAGQVRFWDVADVKGTPTTPTRVATVWTSGTPTYVDVPAGSTFSGRLVDEKADVTVGMPIVSAKYAGYGIVAELAGDQAYKIADTKGTVQAQIKNGPGPFDCALLGTIAALPAGTVPAEPPAKPDAEKPGATGVPTPQPQTAAPEPKTGSDSTGLRLVCTPPADVKMVNGASATVEVVTGSATQALVVPVEAVAGGQGRGKVEVVGDDGKRTIVDVVLGLTDGKVIEVKSGLTGDETLAVPGPNLPQVPEAQPGGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5P8</accession>
    <name>A0A7W7T5P8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14555" checksum="C322B01361A61471" modified="2021-06-02" version="1">MARFLLLMNYGATLDCDIPMHEWAREDVDRHITFQHDLGRELTERGELVDAQGVAGPEAAKIVTYKGDGAPVVDSGPFPERREFLAGYWLVDATPERALEIAAKASAAPGPGGRPLGQPIEVREIMGAPDTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5W5</accession>
    <name>A0A7W7T5W5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system OmpR family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_004521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="242" mass="27117" checksum="DB2D6A9255111E96" modified="2021-06-02" version="1">MREVTSPELRRPDGTPVRVLVVDDESTLAELMSMALRMERWEVRTALDGANAVRVAREFRPDAVVLDVMLPDFDGLEVLRRLRADQPALPVLFLTAKDAVEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRTGVTEATAGTELVVGDLVLDEETREVRRGGQAVELTATEFELLRFLMRNPKRVLSKAQILDRVWSYDFGGQANIVELYISYLRKKIDAGRVPMIHTMRGAGYVLKPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T665</accession>
    <name>A0A7W7T665_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surfactin synthase thioesterase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="26921" checksum="2AA3D7FA34E742E9" modified="2021-06-02" version="1">MIEMSWLRTFTPRPNARFRLFCLPHAGGVAGGYRPWVDLLPADVELVAIQYPGRQDRFGEPCARSVADLAAGAGTAVADLLSVPYAVFGHSMGATVAFEMIRSFQKAGARLPVRMFASARTAPSRSRSTGVDPSDEEELLAHIRRLGSAGGASLDAEPRLRPVVLPSLRADLEAVNTYRFAGGEPLRCPVTAIAGTTDASVERADVKAWRLHTTQAFEYHELPGGHFYLEESTAELVSLVVSTITDAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J4</accession>
    <name>A0A7W7T6J4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31721" checksum="3CA857A929931831" modified="2021-06-02" version="1">MTEHDRRSAERHPRPEEVPGQEQAHPGTASEMAPEPDHGEYSYRGRGRLSDRRALITGGDSGIGRAVAIAFAREGADVVLSYLEQEQEDAERTAEWVREAGRRAVLVPGDITEEKHCAHLVERCASELGGLDVLVNNAAYQMSQSDSLLGISTEQFDRVVKTNLYAMFWLCKAAVPHLGKGSAIVNTSSIQASRPSPELLDYATTKAGIVNFTKGLAQYLAVRGVRVNSVAPGPVWTPLIPATMPAEKVDSFGADTPLGRAAQPAELAPAYVYLASAESSYVTGEVLAVTGGLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6J6</accession>
    <name>A0A7W7T6J6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA-binding transcriptional regulator AlpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="8028" checksum="2792A21E691DAE69" modified="2021-06-02" version="1">MNEPMLESQWYTTDELASRLGVDSSTVRRWRTSSPVQGPPFVRLTTRVTLYSAADVEAWLTERRIDPGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K8</accession>
    <name>A0A7W7T6K8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="25459" checksum="E9B032147A2E8418" modified="2021-06-02" version="1">MDRRVAIVTGAARGIGAAVAARLARDGLAVAVLDLTSEACADVVADIRAQGGTAVAIGADVSDTAAVDAAVDRVVAELGPPTVVVNNAGILRDNLLFKMTDDDWDAVLGVHLRGTFLMCRAVQRHQKAAGWGRIVNLSSTSALGNRGQANYAAAKAGVQGFTKTLAIELGKYGITANAIAPGFIATDMTAATAERLGMSVAEFERGVAAVTPVNRIGTPEDVAHTASFLVSEGAGFVSGQVVYVAGGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6L2</accession>
    <name>A0A7W7T6L2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">F4559_004872</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4967513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="236" mass="24181" checksum="DACBF2188CF13ED9" modified="2021-06-02" version="1">MGHGELRGVVALDGPSGTGKSSAARRLASALGARYLDTGAMYRAVTLAVLRSGADLDDADRVAAVARDAGLAQGTDPADSTTTLRGEDVGVEIRGPEVTRAVSPVSANPAVRELLVAEQRRIVAHALSAVGGIVVEGRDIGTVVVPDAGLKVFLTADARARAHRRARQDGLESTVDAVLADVERRDAYDSSRAVSPLRPAPDAVELDTTDLDLAGVLAALLDLAAGRGLVAGPVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6P4</accession>
    <name>A0A7W7T6P4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007801">
        <property type="entry name" value="UPF0276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42194">
        <property type="entry name" value="PTHR42194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05114">
        <property type="entry name" value="DUF692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="267" mass="28951" checksum="BE515015EA9E69E3" modified="2021-06-02" version="1">MTERLGVGIGWRPEIDLTVERLPGVDFVEVVAENLHVGHLPESVLLLRERGIPVLPHAVSLSLGGADPVDPKRVAHLAALAEAVDAPFVSDHVCFVRAGGLDSGHLMPVPRTRDALDVLVANVRSIQPDLPVPLALENVAALLEWPDGELSEGRFLAELVERTDIHLLVDVANLYANARNLGTDVDRFLDEIPLERLAYVHVAGGVEHNGLYHDTHAHAVLPEVLDVLAALRDRVDPPGVLLERDDDYPSDAELAAELAAIRAVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y6</accession>
    <name>A0A7W7T6Y6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_005068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="462" mass="51075" checksum="100209F20A19F4D0" modified="2021-06-02" version="1">MNWTVDVPVDTLPELPPLPPELRTRLDDALARPAHQQPEWPNAEQVDRVRAVLESVPPITVPAEIDRLRDNLAEVARGEAFLLQGGDCAETFADNTEPHIRANVRTLLQMAVVLTYGASLPVVKIGRIAGQYAKPRSSNIDALGLPSYRGDIVNSLVATPEARVPDPSRMIRAYANAGAAMNLLRAMTQAGMADLHRLHDWNKDFVRTSPAGERYEALAAEIDRGLRFMSACGVNDTSLHTTEIFASHEALLLDYERALLRLDTNSDQPKLYDLSSHFLWIGERTRQLDGAHIAFAELLANPIGLKIGPTTSPELAVEYVERLDPHNQPGRLTLISRMGNGKVRDVLPPIVEKVTASGHQVIWQCDPMHGNTHESSTGYKTRHFDRIVDEVQGFFEVHRRLGTHPGGIHIELTGEDVTECLGGAQEISDTDLAGRYETACDPRLNTQQSLELAFLVAEMLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6Y8</accession>
    <name>A0A7W7T6Y8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="42" mass="4650" checksum="105A9FBE17F54066" modified="2021-06-02" version="1">MVLLQDFDAPAWVWTAVDIAVVLGLVVSIVLGVRALRSDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T755</accession>
    <name>A0A7W7T755_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="451" mass="49292" checksum="A5D40E259A52D765" modified="2021-06-02" version="1">MPREDDVGGSERDFFTHPLAYVRAERGWTYQDLVDVVARHVGNIAARREKAWRWENWGVVPDEDSQNALATELGVPREHVRRLGWPAWLPAGDRVNIELPWTADASRSMLDHTAGAAVLDRRGFLTLSSGTMVTIANQWLGLEHAKVDSVLRGGRVDTALVECLERRLPTVRQMLDSLGGGNVRDLADAELKLVTNLLSQATYGEKIGTRLFGVAAELGRIAGWASFDAGYHASAERYFLAGLRAAHSAGDRVSGANILKCMSLQLVDADRAEEALAVAKAARDGAKGASKRVLAMMTVREARANAVMGAASECEALLVRADQAMCASDDQSDPDWAGYFDHAEYSAQVAACYMLLKRYRLADQWLGRSLALQPIERAVDLSTYLIWRAEAVLELGEVDQACALVGEAVPLIASSRSTRNRRRLAGIRSKLAVHDHPAIVGLDEQVRSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T797</accession>
    <name>A0A7W7T797_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase involved in cell wall biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="250" mass="27445" checksum="D41376D7D59F3528" modified="2021-06-02" version="1">MTALWVVVPAYNEERGITATLEALAAQDDRDFTLVVVDNASTDSTVDVIRSFAARHPVLRLEIVHEPEKGTGAAADTGMRHAIAHGATWLARTDADCLPAPDWTARVKAAFGSGLRLVSGRLLPRTDEGLSAVERGVLVAAVEVAGLFGRIRPGNRDPRYLGPYVMTAGCNMAVTAELYTLSGGFPRTRIEDVHEDRALVNAVRRHTTAYGPRRDVVVRGSSRRALAWGLRRTLAWYADHRYRPEHVDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7I0</accession>
    <name>A0A7W7T7I0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative copper resistance protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="8">
        <location>
            <begin position="224"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="651" mass="69627" checksum="B42F342425B8ED58" modified="2021-06-02" version="1">MSTEAQARTLRTGLVPLLAVGATIAAALAAAIAAGTEGDKSGLIVVRVLTESAAVVTIGSLLLAAFLTPPKPSGRLAADGYAALRTAAWSALVWTLGAVLAVPFTVAEALNQPVTELLDLQLIFQFAGLAEQTRAWMITAVVVALLALGCRLTLSWGWTAVLFLVSVFALFPVAVTGHSSGGGSHDVATNSLLFHLVAAALWVGGLIALLAHGRRGGVRLDLAATRFSRLALVCWIVMGLSGVINAYVRLPIDKLFSSNYGWLVVGKTVALLVLFVFGYFQREKGVRAVVEHGTKRALLRLAGVEVLLMFLTIGLAAGLSRTAPPPEGRTFPSTVELRIGYDLNGAPTLERLLFDWRFDLVFGTAALLLAVLYLLGVRRLRKRGDAWPVGRTVAWVAGCLTLLFATSSGLGRYAPAMFSVHMETHMLLSMLVPVLLVLGGPVTLALRALPTAGKDNPPGPREWLLALVHSPVAKLLTNPFVALALFVGSFYGLYFSGLFDVALKHHWAHLAMNAHFLLAGYVFYWPVIGVDPAPNRLPPLGRLGLLFASIPFHAFFGITLMSSQTVIGDDFYRGLSLPWVGPLLEDQRLGGGIAWAAGEVPLIVVMVALLVQWARSDDREARRADRRADADGDADLAAYNAMLRKMSGKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7U6</accession>
    <name>A0A7W7T7U6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flp pilus assembly protein TadG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="163" mass="17116" checksum="95B742E54DED89DE" modified="2021-06-02" version="1">MTRRGRHSRRSWWSTSWSTWWRTRLRWWRADEGRVTAFVLAMTVGILALAGLTLDGGLALAAKVRANGQAEAAARAGAQAIDLTAYRGNGRLQLVPAQAVANAQAHLTAEGATGAVTVSGDTVTVTVTASQPTQLLGLVGIGSLQVHGQGSAHPQRGVTAIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7V9</accession>
    <name>A0A7W7T7V9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4967916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="169" mass="19511" checksum="0ADD8920F98B2DEE" modified="2021-06-02" version="1">MEEDDIWIRLNNGWEFSGIGRQLEGQTEGHGFGWALWQPGYVARPWPYGELKPGFTYYLCDKGFGERAVTARATVVRDPLTVKVHSVQDAFDALLELMFDDLTWMPHEVWHANPYNRLKFDSPWPQRLTAWRVVTEPFGPLFRSELARFPRCGWLKSPATILGEEALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T819</accession>
    <name>A0A7W7T819_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding LacI/PurR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_005365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4968006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="351" mass="37068" checksum="BDAD3169E8AC4C3C" modified="2021-06-02" version="1">MDRPRKPTLDTVASAVGVSRATVSNAYNRPDQLSAALRERILAAAQALGYAGPDPVARSLATRHSAAVGFMLGHRLSASFSDQALSVVLDGLASTVDGHDHCLVLMPGHDRGGPRPSTVSRAQADVVVAYSLPDDAPALAAVRARGLPLVVIDQPVLPDTARVEVDDYAGARMAAEHVVARGHRRVAVLTFALRPDGRNGLVSPVRRGSASFRVTRDRVNGYLDVLGDVPVWECADSTRELARTGARELLSPSPTRPTAVVCTSDELAFGAIQAARDLGLRVPEDVSVVGFDDIPAAQHADPPLTTIRQPLAEKGRRAGELALRLLDGGRPGEPSRVALGLVERESTTAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8E5</accession>
    <name>A0A7W7T8E5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_005841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="221" mass="24079" checksum="38DF560007B79725" modified="2021-06-02" version="1">MTTLNPAPALRPRMRGWLHLWSFVVSVGTGATLIALAASTASTKATLAVSVYGVTVLGLFGVSALYHRVNWVSARARTWMKRLDHSMIFVFIAGTYTPFALLAMPPDTGNVVLAVVWFGALGGVTLKLVWPHAPRWLGVPIYIALGWVAVFVLPDLLEHVGVGALVLIVVGGLLYTAGAIFYASRWPDPWPRVFGYHEFFHAATVVAALCHYIAIWFAVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8U7</accession>
    <name>A0A7W7T8U7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="43994" checksum="1A4681DD6001692E" modified="2021-06-02" version="1">MKRLFGRVAIDTAPLKIAAYRRLWLSTVVTAVGSQLTAVAVPKQVFDITGSSGWVGITAAVALIPLLVFGLYGGAVADLVDRRKLLVVTNIGIAVTSVLLWVQAALDVRSVWLVIVLLGLQQVFFAANAPARTAAIARIVPDHQIPAATALGATVMMFGGVFGPMLAGALMPVVGLPTLYLVDAIALTLTIWSVWRLPPMPPAGGESRRAGVADVVEGFRYLAVRKVLLASFLLDIIAMVFGMPRALFPEMAERTFGDPPGGGLALGWLFAAIPLGALLCGLVSGWTSKVMRHGVGVVFSIVAWGVAMIGFGLSHALWLAVVFLAIGGAADMISMVFRSAMLQTAASDEMRGRMQGVFTVVVAGGPRLADLVHGTGGAAVGAGVATAVGGVLVVVATVVATALIPAFWRYRFDPRPSPHTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Y9</accession>
    <name>A0A7W7T8Y9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="61" mass="6837" checksum="A2DB786EBB6FCD7E" modified="2021-06-02" version="1">MAKARPERIDPHWPEAPADHKHPVTELTSDRQGALSPFGTTAFPLPVDQLGYHHPTTEINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9J3</accession>
    <name>A0A7W7T9J3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="381" mass="38775" checksum="31F1D83DB79F5E40" modified="2021-06-02" version="1">MAGSDPKTTNAPNLGENCNWMVYSHQQLYDMIHTGVDLQSASTAQVNWDGIRKALVEVQDLLKEAVVKSTRAWQGKAAEDARIALASVEKWAMTTGDHADNVAKCIGSEIEHVQTARRLMPAPVPTPPVVTPVDGISQVKQVDQARALNPATDARSPFTGADTIAGPVVDSVVEADSAHRQAADVMAMFQQNSYEVDRTVPSFAAPPEPPTSGPRPTPPVGVGPIQQPGSGGGGDVVPPKPGHPDVPSGTTTAQTGRGSGGFGGGAGGGGGYGGHLPSPLAAFGGGGGAAGDVGFTPGVGGSTGALADRPPAHPGSTTSHFQSPKTVTPHAGMIGATPMAAPPPVAGGNSEDRDRNRPDYLEEEDNVFGVDRKAAPPVIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9M8</accession>
    <name>A0A7W7T9M8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="40" mass="4354" checksum="0ED0CC84E44370A1" modified="2021-06-02" version="1">MSAIENGYRRPSPNLLVRLAEVLDCQPGDLLLDEPQTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9N6</accession>
    <name>A0A7W7T9N6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024411">
        <property type="entry name" value="Minor_capsid_phage"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12691">
        <property type="entry name" value="Minor_capsid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="144" mass="15459" checksum="E9D2F192B685AFDC" modified="2021-06-02" version="1">MSWTTRLAHGLAELLTDTGVAVYRPTGIYRDAEVGIVVGIVPAAPPSVLVLTPYALVDDVDQADSVLGLQVRARAAGPDPRPALDLLDAVFDELHGATHLDLGGALVHLAQRTASVPLSRDQSGRYEHADTYQLTAHRPTRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9S5</accession>
    <name>A0A7W7T9S5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
            <ecNumber evidence="8">1.10.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.-" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4969164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="35750" checksum="BFA56C342B9EE2B7" modified="2021-06-02" version="1">METLWFCVIALLWLGYLFLEGFDFGVGMLLPVLGRDETERRVLVNTIGPVWDGNEVWLLVAGGATFAAFPGWYASLFSAAYLPLTLFLLALIGRGVAFEYRGKVDSARWRKLWDTLIFVGSWVATLGVGLVLSANVFGLPLDANGDRVGSPFAAIRPETLLGALAVAGYALVHGAVFLSLKTEGDVRARARALALKIAPVALLPLLVLLLVVQLHSGSAWTWAASVAVALAAVGAYVRLYFGREGQAFALMGVAVAATVTALFGALYPNVLPSTVDPTFSLTVADTASSSYTLTVMTWVAAFGTPAVLIYQGWTYWVFRKRIGTRHIPAVHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9V5</accession>
    <name>A0A7W7T9V5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_006490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="154"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4969131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="394" mass="45057" checksum="33C46A3619B3EB88" modified="2021-06-02" version="1">MSFAGYDLIVVGSGFYGLTVAERAASQLDKKVLVVERREHIGGNAYSEAEPETGIEVHRYGAHLFHTSNKRVWDYVNQFTAFTGYQHRVFAMHDGVAYQFPMGLGLITQFVGKYLSPEQARAWVAEHAAEVDAADVQNLEDKAISLIGRPLYEAFVRDYTAKQWQTDPKNLPAAVISRLPVRYTFDNRYFNDTYEGLPVDGYTAWLERMADHPNIEVRLDTDFFDVRAEIPHGTPVVYTGPVDRYFDYSEGWLGWRTLDFEQEVLPIGDFQGTPVMNYNDADVPYTRIHEFRHFHPEREYPADKTVIVREFSRFAEKDDEPYYPINTAEDRAKLERYRELAKREAAERNVLFGGRLGTYKYLDMHMAIGAALSAFDNKIAPHLTTGASLDGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T9Z9</accession>
    <name>A0A7W7T9Z9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein (DUF485 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="116" mass="12871" checksum="74B1167BF8D9910E" modified="2021-06-02" version="1">MSTTEHSPTNSADAGHDWVEVQNSADFVELRKRLRAFVFPMAGLFLAWYLLYVLLADYAHGFMSTKLVGNINVGLVLGLLQFVSTFAITTLYVRHANKNLDPRAEAIRAKLEGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAA7</accession>
    <name>A0A7W7TAA7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA polymerase-3 subunit beta</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">F4559_006311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="10">
        <location>
            <begin position="127"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="11">
        <location>
            <begin position="248"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBB4968952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="366" mass="38222" checksum="B3BC458BE3BBCAE0" modified="2021-06-02" version="1">MDFTASTAGLASAAADVARLLPTRVVDPVIAGLVLRATGSGVELAGNDRERAVSLSRAATVHDEGAVLVPARPFAETLRGLDEPQVRVVVEGSRLAVRTGRGRFALPLLDLHSHPGVPALPPLAGRITARVLASAVVPVAGAASKEDALPVFTGVHVQGAGSRLELIATDRYRMAYSSLPWSGGELDVLVPASLLAEVVRQPGAGDEVSLHADDDRLALAWRGGSVSTALLAAPFPDDRARKLLEATIDSTVLVEADALAGAVRRAVPYAGPHGAVTLQVDDGEVRVRGSDPQAGESEESIKATVDGNRLTKSFQARYLSDALKAFSGRRVELRIQDGLRSTVLTAQAGDDGVELTYLVVPLRTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAF4</accession>
    <name>A0A7W7TAF4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YukE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="291"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4969508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="382" mass="38949" checksum="022D2EF4329446A4" modified="2021-06-02" version="1">MSAKDEVAGLPGGAAVAAWADKVDSAQPQAVRDVATRWREAATKAGEAGNVVQRTVSALDGAWEGGSADGFVTYMSGFTKSGTALAEALTAAAGDLDSAANALEAAKTTMTRICENLLSRARQVREQNRHMPQADVDAAISGLCAEAAGDAGPVIEQAETAVNSALSALKGRVFTPAFSSLPDPGTQSFVPAPGNPIDWQPTPEAETKPSSATETPQHQQSPSQSTGGSHGGGGGGGGGGGSAGGGGFGGFGPSGPPPASGPPPGNVEQWIREAIKILQAAGIPVTEANIQQIWTIIEKESGGNPHAINDWDSNAAKGTPSKGLMQCIDPTFQSYKLPGHDDIWNPVDNIIAGVRYTFERYGGFEGHPGLKSMAQGGGYQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG5</accession>
    <name>A0A7W7TAG5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="57" mass="6604" checksum="14DB484BA85B7200" modified="2021-06-02" version="1">MTDACSRCGRTRASVTDPVLSLAWVREREDGVERWLCHECARTHVRDIEGKLPADYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TAG9</accession>
    <name>A0A7W7TAG9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysozyme</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031369104" description="Lysozyme" evidence="5">
        <location>
            <begin position="27"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="257" mass="27921" checksum="A50D8125CC3B1C61" modified="2021-06-02" version="1">MRPLARVAAVLVSCAGLALVGTAATAAPVVDHAMGSQIVKHEGVATGFAAPAAQAAVEGVDVSSHQGNVAWSTYWGQGKRFAYVKATESTSYKNPYFAQQYNGSYNVGMIRGAYHFALPDKSSGATQADYFVDNGGGWSRDGKTLPGALDMEYNPYGATCYGLGKTAMTAWIKAFSDRYRARTGRWPVIYTSTNWWNQCVSGDFSSTNPLWVARYSSSVGTLPYRWNVHTFWQYTSSPIDQNRFNGAQDRLKALADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TC05</accession>
    <name>A0A7W7TC05_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="6" type="ORF">F4559_006359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="5">
        <location>
            <begin position="68"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4969000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="597" mass="66023" checksum="6E65EE729F614B50" modified="2021-06-02" version="1">MTTSPDAYSTGISRIRKPARPAPGDQPAWNRQLGTSMPVHRYRPFHELVETVDVPDRTWPTKRITQAPLWCAVDLRDGNQALIDPMSPARKRKMFDLLVRMGYKEIEVGFPAASQTDFDFVREIIEDGAIPDDVTIQVLTQCRAELISRTFESLRGASKAIVHFYNSTSILQRRVVFRSDRDGIKKIATDAARFALEEAKKYPETEFRYEYSPESYTGTELSYALEVCDAVSEIIAPTPDLPLIINLPATVEMATPNVYADSIEWMSRNLKRRESIILSLHPHNDRGTGVAAAELGYLAGADRIEGCLFGNGERTGNVCLVTLGMNMFGQGIDPQIDFSDIDEIRRTVEYCNQLPVHERHPYGGDLVFTAFSGSHQDAIKKGLEALEHDAKEAGRHVDAHPWEVPYLPIDPKDVGRNYEAVIRVNSQSGKGGVAYLMKTEHHLDLPRRLQVEFSRVIQEVTDTQGGEIGPKDMWDSFAGEYLDGVVPLKLVRQKVTSDGTGHERIKALVIVDGDEQEIVGTGNGPIAAFVDALATVGYDVRVLDYSEHALSAGDDASAAAYLECAVGDRVLWGVGIDQSTTSAALRAVVSALNRAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7TC80</accession>
    <name>A0A7W7TC80_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="109" mass="12045" checksum="D13C6C5F6930ED5D" modified="2021-06-02" version="1">MSAWREQTGAAYRPATVRALARHVDDLLRDGGDLVALRAALDEWHRRPGARPGLLPHLYDDAVKITARPRRAAQTPVARSARGEKVRGWLALADEGQDQPHRPAIEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WT76</accession>
    <name>A0A7W7WT76_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="6">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_000274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="7">
        <location>
            <begin position="110"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4962915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="232" mass="24974" checksum="4F06D9DA0F8CB3F7" modified="2021-06-02" version="1">MSKVLREDVNLTVAGRTDAGVHAAGQVAHADLPGGVDVPGLPKRLARALPDDVRVFAARVVPGEFDARFSALRRHYEYRVTDADSGAHPLRRLDTLAWPRPLDLDALNAASALLLGERDFCAFCRRREGATTIRELQRLEWSRDGDVLTAFVSADAFCHSMVRSLVGALLAVGEGRKPVEWPASLLSLSARASGVTVAPPHGLALVRVDYPEDASLAARALVTRNVRVSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTN0</accession>
    <name>A0A7W7WTN0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkylation response protein AidB-like acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_000648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4963289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="383" mass="41693" checksum="B0A2B167505AF5C4" modified="2021-06-02" version="1">MLDFRLDEEYEALRKTVEEFAREEVAPVIGGFYEREEFPYEIVAKMGRMGLFGLPFPEEYGGMGGDYFALCLVLEELARVDSSVAITLEAGVSLGAMPLYRFGSAAQKDEWLPKLVAGESLGAFGLTEPGGGSDAGALTTSARIDGDSWVLNGTKAFITNSGTDITGLVTVAAVTGRRDNGKPEISAILVPAGTEGFSVSRKYSKVGWNASDTRELSFQDCRVPLENLVGERGRGYAQFLQTLDEGRVAIAALSVGLAQGCVDECLKYVHEREAFGHKIGSYQAIQFKIADMEARTHVARLAYYQAASKMLRGEPFKREAAIAKLVSSETAMDNAREATQIFGGYGFMNEYPVGRFYRDAKILEIGEGTSEVQRILIARDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTS9</accession>
    <name>A0A7W7WTS9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">F4559_000406</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102040">
        <property type="term" value="F:fumarate reductase (menaquinone)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="17">
        <location>
            <begin position="7"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="18">
        <location>
            <begin position="454"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBB4963047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="583" mass="64220" checksum="64104FE61E7C922F" modified="2021-06-02" version="1">MQFHKYDVVIIGAGGAGMRAAIESGQRARTAVLTKLYPTRSHTGAAQGGMCAALANVEEDNWEWHTFDTIKGGDYLVDQDAAEIMAKEAIDAVLDLEKMGLPFNRTPEGRIDQRRFGGHTRNHGEAAVRRACYAADRTGHMILQTLYQNCVKHGIEFFNEFYVLDICLTETEDGPVCTGAVAYELATGEIHVFHAKSVVFATGGFGKVFKTTSNAHTLTGDGMGIVFRKGLPLEDMEFYQFHPTGLAGLGILLTEGARGEGAILRNASGERFMERYAPTIKDLAPRDIVARSMALEVIEGRGAGPNKDYVLLDCTHLGAEVLETKLPDITEFARTYLAVDPVTEPVPVYPTAHYAMGGIPTNVHGEVLRDNDNIVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAAEYANAHEHVDLPENPATQVEAQVALVLSEHGHERVADIRTELQATMDANASVYRTEDTLKQALHDVQALKERYQRITVQDKGKRFNTDLLEAIELGFLLELAEVLVHGALARKESRGGHAREDYPNRDDTNFMRHSMYYKQGDGLSADIRMDYKPVTFTRYQPMERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WTZ8</accession>
    <name>A0A7W7WTZ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="47" mass="5450" checksum="26C918990D6F8F58" modified="2021-06-02" version="1">MASLFSKLAAFARSPQGRQAVDRIKHAARDPRTRAKAQDILRRFRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU06</accession>
    <name>A0A7W7WU06_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA editing enzyme YbaK/EbsC (Cys-tRNA(Pro) deacylase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="64" mass="7100" checksum="89322D1EB312EA6C" modified="2021-06-02" version="1">MNREHWLIRVAPLVAAWTLITERFGLDDTVLVAGGLSGAVIALGTHRALGLLRARRCSRCDHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WU15</accession>
    <name>A0A7W7WU15_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease-3</fullName>
            <ecNumber evidence="3">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="264" mass="29189" checksum="82BF95E335B2CD46" modified="2021-06-02" version="1">MLTVSTVNVNGLRAAAKKGYLEWLSATAADVVCLQEVRASPDQLPEEVRAPQGWHMAQAYSDVKGRNGVAVLTREEPQAVRVGFGVAEFEHSGRYVEVELADVVVASLYLPSGDVGTPRQDEKDRFMAAFLPYLVELREKAAADGREVLVCGDWNIAHRPEDLKSWKTNQKSSGFLPYEREWLGSVYDEAEYVDVVRALHPSGPGPYTWWSYRGKAYDNDSGWRIDLHVATAGLAARATGAVVERAATYGERWSDHAPVTVTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUP3</accession>
    <name>A0A7W7WUP3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="97" mass="10651" checksum="25C3F993BA1BAB42" modified="2021-06-02" version="1">MFVGALELDVLLGDVHSLKQKRSVVKPVVAELRRRFEVSVAEAGHLDLHRRALIGVAVVAADAEHVRDVLVACERLVAGRPELELLSARQRLLGPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WUR2</accession>
    <name>A0A7W7WUR2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphocarrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030529188" evidence="4">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="HPr" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="89" mass="8960" checksum="C4F64AE087D9450F" modified="2021-06-02" version="1">MPERRVTVASKVGLHARPAAVLAKAAAGQPVAVTIRKDGGEPVEAKSVLGLMTLGAMHGDEVVLSAEGDGAESALDAIAEIISTDLDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WV43</accession>
    <name>A0A7W7WV43_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YlmC with PRC-barrel domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="104" mass="11874" checksum="59901491B8169862" modified="2021-06-02" version="1">MRRQANSKRLYDCAVLDRRGDRIGSVKRVWLDDHTGRPRWASVHTGLIGSETFVPLQGARVGVGHITVHVDKERVQDAPHVHVRDHHLSPDEDARLCRHYGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW12</accession>
    <name>A0A7W7WW12_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="199"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="588" mass="62820" checksum="5A6B59E07C30D1AA" modified="2021-06-02" version="1">MSFVGVFPPAADRVPARLVPVWSDRPGLWLADGWHPGEVRTARHRDAGLLVLGQCFADDARLLADLRRAVDEDRPGSLTRWPGCHTVVVVRDSGVTVLVDQAGQYPVFHRTGGGRVVFGSHGATTAAVAGLPATPDRSTLLAGVFCPDVPALVGDRSVLVGVRRLGGGGVLTVDRSGTRTAATDPVPDRSTTFADGVDELRAALDAAVAARLADGRTVTADFSGGMDSTSLAFLAARHAPGLRLFAYHHPDAPAHDLEHARRYAGDLRLEIVTGTRETLSYQGLFDVAAGDEPDPAAVASARAALRLGRIGAGGLHLGGEGADALLVPPPSYLGDLARHGWWRGLARDVFAASRARNLSPTTVFRRSLTAAGTSTSRALRGLKTRLEHPRPHVVQWLDAISRWPGPGAAALWLTPRARRELAGLADEAARDRARHPVGDMADHTALHDLRTAGAVQRRLVETARPYGVWPHAPFLDADVIRACTRVAAHLKVSVETRKPLLRAAMADRVPDAVFTRRDKGDYTGEDYLGLRVHASTLVRELRRSAVADLDLVDPAAVIEAVDRAGTGAPVPFPVLNRLLGVEVWLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW47</accession>
    <name>A0A7W7WW47_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CubicO group peptidase (Beta-lactamase class C family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="93" mass="9700" checksum="85114DEB9F486957" modified="2021-06-02" version="1">MAATIAPTAVAEPQFDPDAVDRYVREYADNAAYPGVAVAITRGDRVVHLAGYGHTSTGAVRGHVSAIVTRLDLANRVQPAVLAHDAGLVARPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WW77</accession>
    <name>A0A7W7WW77_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na+/melibiose symporter-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_003439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="236"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4966080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="427" mass="44816" checksum="83E2C3578AABE9D4" modified="2021-06-02" version="1">MPTEDITTTAPPEARLRDLWRNPDFVKLWIGQAASEFATQVTTLALPLVAVLALDATAGQVGTLNFLAQLPYVLFALYAGVVVDRLRRRDVLLAVDLGRAVVLAAVPVLAAFGGLALGPLYAVAFLIGGLTVFFQVAYQAYLPTLVDRRELSGGNSLLETSRSAAQIGGPALGGGLVQLLTAPFALVGSAAAYLVSAWTFWLIKAREDKPERGERGVKATVRGIGEGLRVVFGNPALRANALMASLFNFGFYAFQTTFLLFLPRELGLSAGQIGIVLAGLGPGLLVGSLFAHGLPRRIGYGRALAITAFLANGSMLPVFLLHGDGWSTVLALAGLNFLFGMFGTANNVAMLTIRQAVTPDTLLGRVAASVRFFAQGASPLGALLGGFLATALPLRTAVGLSSTLLMLGFVVLALSPLTRIGRELPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WWU8</accession>
    <name>A0A7W7WWU8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="3">
        <location>
            <begin position="64"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="245" mass="26410" checksum="C43AEF2E2A0DC02A" modified="2021-06-02" version="1">MTRLIRVADSGSGLYDGIIGFARATPGWFQGLGELYTEVGLLLFGVFFLVAWWRARATGRVRAVTRALLAPVVTVGAYVSSELLKLVIHEDRPCRGLPVDAIIAECPEIGDWSFPSNHSAIAGAAAVGLAVAWRRVLPWVVAIALLMAFSRVFVGVHYPHDVLVGLLFGAGVALVSIKALEKRAFSLVGKLGARRDFVGRLLFAVPPVGEEPTRRLPRQRDLGRPGDRGAIDGPTLREPRQGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX01</accession>
    <name>A0A7W7WX01_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="342" mass="37105" checksum="D16253654150B89E" modified="2021-06-02" version="1">MRTLVVGLGRAGAGLHLPVLGRARAAARRLFSTEPVVACEPRHNALRRPGLITTNSLAEAATHLDPADTVAHVCTPPTVRAEVFAELAALGFRDLIVEKPLAADTDELARLIRLRRKHGLRVAVVEPWQSSTLTSRLITLATGGTLGEAKSITVVQNKPRFRRTLTMPGYPTAFDVELPHGLGLALRLAGSARVTHAAGFDLTFGDVVIPRMGGARIGLRHNSGVRTEISSDLTSPVRERRVTVEFEKGTAVGHFPVSDDDDHAQLTVTANGRREHSVLRDDALAEWMVQTYSRFHSPSDQHARHFSFATDVVQLLAVAKNICAEPVVSSARREPAVSLHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WX69</accession>
    <name>A0A7W7WX69_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha,alpha-trehalose phosphorylase</fullName>
            <ecNumber evidence="8">2.4.1.64</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.64" evidence="8"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047656">
        <property type="term" value="F:alpha,alpha-trehalose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="5">
        <location>
            <begin position="323"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="6">
        <location>
            <begin position="695"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="588"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="779" mass="85075" checksum="2A5976BCF781DC07" modified="2021-06-02" version="1">MTGYLVDPWTLRWDGLSIADLRRTESTFALSNGHIGLRGTLDEGEPRGLPGTYLNGFFERHALPYGESGYGYPEEGQTIVNVTDGKVIRLLVEDEPLDMRYGRAVEHHRELDFRTGTLRRFTEWESPTGRRVRVRSERLVSFTQRAVAAIHYEVEPLDDVQLVVQSDLLANEPIEHEVGDPRVAAALDAPLIGDFSAASEAKAVLVHHARNSGLRVAAAMDHEIEVTDNLRAGMESNGDLARYTVAADVGAGGRFTLTKYLGYGWSAQRSVPALRAQVEAAVAGARQTRFAGLVDEQRRFLDDFWAAADVTVDGDPELQQAVRFALFHLLQAGARGESRAIAGKGLTGPGYDGHAFWDTEIFVLPVLTYTVPDAARDALRWRHSTVDKAVERAGVLGQRGAAFPWRSIDGAECSAYWPAGTAAFHVSGDIAYAVAQYVAATDDREFEADHGTELLVQTARLWASLGHHDQHGGFRIDGVTGPDEYSAVMDNNTYTNLIAQRNLESAAQACERHPEVAGRLGVSGAEISAWRAAANRMVVPFDRLLGVHEQAEGFTSHAEWDFAGTSPDDYPLLLNRPYFDLYRKQVVKQADLVLAMQLRGDAFTPEQKAANFAYYEARTVRDSSLSAGTQAVLAAEVGLAQLAYDYVSEAAFTDLHDLHHNVHNGLHMASLAGAWTGIVAGFGGLRDHSGVEFAPRLPPGLDGLSFRLTYRGTRFRVRVAADSATYEVLSGPALETSHHGEPLRVEPGVPVTRSIPDPPAPPVVSQPTHRVPRRRVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WXI7</accession>
    <name>A0A7W7WXI7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030994383" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="76" mass="8399" checksum="51191BDC4A5B0BD5" modified="2021-06-02" version="1">MMRILAAVFAVVWALVLPRAAGASADSWWVTEGYRNDQAECVAEKNATWATGFVVSPAGPTCLHIPRGYYYQYLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY17</accession>
    <name>A0A7W7WY17_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="138" mass="15304" checksum="DAE36348AA9C07DD" modified="2021-06-02" version="1">MLIGELAEKTGATVRMLRYYEQQGLLTPPRTAGRYRVYDDADVARVRSVRCLIASGLNIKLVRLVLAYAFDQEVDLPEDDAGCVPLLLMLRDELTSVDERIVALETSRAHLTRLVSDVERIMVERGQAPCADPAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY31</accession>
    <name>A0A7W7WY31_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydrolipoamide dehydrogenase</fullName>
            <ecNumber evidence="6">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_005146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="4">
        <location>
            <begin position="344"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="458" mass="46988" checksum="170BFB852398693D" modified="2021-06-02" version="1">MSDYDVIVIGGGPVGENAAARTAAAGLRTVLVEAERVGGECSYWACMPSKALLRPGHALAAARRVPGVPVGDRIDPVAVFARRDGFTSGWDDAGQVEWATGAGIEVVRGRARLVGERRVSVDGRELAATRAVVVCTGSVPRTPPVPGLADVPSWTSRDATSAHEVPPALVVLGGGVVGVELAQAWARLGSDVTLVVSGDRPLPRFEPFAGDAVVAGLRADGITVETGARAVSASTVDGGVALGLADGRVVSGSHLLVATGRQPATFDLGVEAFGFTPGQALPVDDLGRVSGVDWLYAAGDVTGRAPLTHQGKYAARAVGTAIVAGTTSAPPWSAAVATADHTAVPQVVFTDPEVAFVGRTAAQAREAGLDVRVVEIDIAVAGSSLHADGYTGRAAMVVDERTRTLVGVTFVGPDVAELLHAATIAIVGEVPVDRLWHAVPAYPTISEVWLRLLEAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WY69</accession>
    <name>A0A7W7WY69_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031540954" evidence="1">
        <location>
            <begin position="23"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="378" mass="40725" checksum="68059977D73A2C3F" modified="2021-06-02" version="1">MFLLVVVLFLTVASVPVTDDMAVRDVLDRRSRAVLTRDETAFLADLDPHASPAFVDAQRALFRNLSAVPLAQWSYRVDDAAVPDGLTADADSLATPRVGLEYRLRDVDTVPSVRDMAYVFTRRGGRWYLASDTALERFGRHTWRGPWDFGPCAVLDGPAGFVLAHPGGEEFAARVSAELPGAVDAVRAVWGPWNGRVAVYVPAGREELNALVGPGFAAGLAGIAVSDPGVASGQRVVLASPLPTASLRVLLRHEITHVVARGATADGAPMWLLEGFADYVGYRGLGTGWASTLAAEVRAGRLGDLPSDADFRTDPEPAYQRSWSLVAYLAAVLGEPRLVGFYRLLARSSDVEGALRTFGLDRAGVVRGWHDFLRSTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYM4</accession>
    <name>A0A7W7WYM4_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">F4559_005731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4968372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="145" mass="15522" checksum="1F2E1B8C1B4A4BCD" modified="2021-06-02" version="1">MAKSDESTAKPAEKKKSKKLLIIIVAAVLVLGGGGAAYFMFFKGESTPPPPEPGKVIALEAITLNLKDGHFLKLSLALQATADATGELDGSRALDLAVSEFSNRSIAELSTSEAREAGKAELLKKIEEAYEGQVMDLYFTQFVMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYQ8</accession>
    <name>A0A7W7WYQ8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022536">
        <property type="entry name" value="EspC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10824">
        <property type="entry name" value="T7SS_ESX_EspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10956" checksum="7079F1DEAFF54874" modified="2021-06-02" version="1">MFDSFHVSPEEVRAHAATVDQLTQRMLAATKTADPSLSSDAFGIFGGFLASFLLRTAGMSQDLFGQATETVADMCQGLREVADLYENIDLDNAFGFSGKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYR2</accession>
    <name>A0A7W7WYR2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanine aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">F4559_005342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="15">
        <location>
            <begin position="38"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="13">
        <location>
            <begin position="240"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="14">
        <location>
            <begin position="535"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBB4967983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="853" mass="94369" checksum="EE973458BEBD1C17" modified="2021-06-02" version="1">MAAPNLTRDQAQQRAQLLEVDSYRIELDLTDGGGKPGSETFRSTTTVVFRSRTPGASTWIDLVAATVHRAVLNGVELDVSGYREEDGIALADLAEVNELTVEADCRYMNTGEGLHRFVDPVDGGVYLYSQFETADAKRMFTCFDQPDLKSVYDIAVTAPHDWKVVSNAAITSTGDGVGGADRHVFATTKPMSTYLVALVAGPYAEWRDEFVDGDVTIPLGIYCRASLAEHMDHERLFTETKQGFGFYHKAFGVTYPFGKYDQCFVPEFNAGAMENAGCVTFLEDYVFRSRVTRYLYERRAETVLHEMAHMWFGDLVTMRWWDDLWLNESFATWASVLAQAEATEYRQAWTTFAKIEKSWAYRQDQLPSTHPVAADIVDLQAVEVNFDGITYAKGASVLKQLVAYVGLDNFLAGLRVYFAKHAWGNATLADLLGALEEASGRDLSWWSAQWLETTGLNLLRPKYSVDADGKFTEFAVLQGGARPGAGELRTHRLAIGVYDADESGKLVRTHRVELDVSGERTEVPELVGVARGKIVLVNDDDLTYCTMRLDPDSLAALVDHISDIAEPLPRTLCWSAAWEMTREAELKARDFVNLVLGGLHSETEVGVVQRLLLQAQTALSSYADASWRDEGWRRFTAKTLELARVAEHGSDHQLAFVNALAGSVLDDEAVGVLKGWLSGTDVLPGLDVDTDLRWRLLHALVAHGAADLPEIAAEEERDPTATGRRRAESARALRPTVAAKEEAWDRAVNDDELPNAVSEAVVGGIQHPSQKALLQPFVARYFADVAEVWERRSSERAQSVVVGLFPSWSISRETVGAADAWLAEERPPALRRLVSEGRAGIVRALAAQEFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYT0</accession>
    <name>A0A7W7WYT0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011200">
        <property type="entry name" value="UCP012608"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10094">
        <property type="entry name" value="DUF2332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="361" mass="38512" checksum="64813179B0CBBC56" modified="2021-06-02" version="1">MTDLDLVRDRLSRFARLDAPGVSPLYEHLSANAALDDDVAGLLTAAPEPFAHPTLLLAAAHRLVQAEPVHPLADYYPSLGGTYGADERTWPLFRSFVLERADRMRALISTRTTQTNEVRRAALLYPALARIKGPLGLLEVGCSAGLLLGVDQYNYRYQTEQAGQLVAGPTKAALGLHCALELAPGAVLPKLPKTVKVGAKIGLDVAPADLSDEDTYAWLEACVWADQPERLRLFGVAAGVQGKSRPELVTGDAVADLAKAAALVPADLPLVVVTSMVLEYVSGVEFVAALRALDRPAWWVSHERYTAALEHVLPGRADLAPGAEGPEPIVLGLARVEDGEVVSAQALATTAPHGQRLVWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYV8</accession>
    <name>A0A7W7WYV8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system chemotaxis response regulator CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_005745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="128" mass="14224" checksum="DAF07220E8534DF0" modified="2021-06-02" version="1">MVIDDSRAMRRILRTVLQEVGYEVVEAGNGQEALDLLGTEEAETRVPELALIDWNMPIMTGLEFVVNARKQQRLRNMSLIMVTTESEHGQIVRALASGAHEYVIKPFTRDALHDKLALLGLLPAGVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WYX0</accession>
    <name>A0A7W7WYX0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-DNA-T family DNA segregation ATPase FtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_006333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="162"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4968974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="394" mass="43741" checksum="64FD1777D63393D4" modified="2021-06-02" version="1">MGTAAWYRAHPDTFDAWAAPVLRSWRRRWLGAYAGRRWQALMGSCELTRRHHRSGALLVPRVVRVRSSLSLDTVRVRLVQGQALRAFTAALPELAATLRVERVAVEQARPGEVVLIVQRGEPFDRVIPAPAMPETSDAVDLRSLCLGETELGGEWREPLIGTHHLTAGATGSGKNSVVMAKLRAVAPMIRDGLVRPWVCDPKRFEFVALKPMLDGRYADSPEDCADLIARFVDNMERKQKRLQRKKKRAAKVSAEHPVDWLILDEVGFLMAYRTDYAHEITNACAIVSSLGRATNDVLDVYVQEPAKDVVPIRDLIPHRLCLRVTSDRHPDMVLGDGARKRGAIADQIPADESSAGIGYRVDARSRTPRRVRAAYTTDHDVAELVAFVKTGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZ95</accession>
    <name>A0A7W7WZ95_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">F4559_006150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBB4968791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="315" mass="34283" checksum="8C2DA497033F61AB" modified="2021-06-02" version="1">MAPSGPGIRLLPNAITVLAMCAGLSSVYFASIGMWAASIASIGAAAVLDGLDGRLARLLDATSKMGAELDSLADAVSFGVAPALVVYLWRFESAGLGDRTGWVVCLIFAVCMVLRLARFNTLLDVEQPPFAKEFFVGVPAPAGGLLLLLPLIVDEQLRRSGWWSQPWVVAVWTVAIAFLLVSRIPTLSVKTVKVPQRFIVPLLLFIALLAAAVVTYPLVALISAMLLYLGHLPYSVRRYRWLARHPEAWEVPAADRRAIKRAHGVAARRLGLRQPLGGRVAGAAMRAVRRPRRSSEPGEGKRRGWRTLGLRRQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA4</accession>
    <name>A0A7W7WZA4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.28</ecNumber>
            <ecNumber evidence="2">3.5.4.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="2"/>
    <dbReference type="EC" id="3.5.4.31" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="433" mass="46224" checksum="FE9EA24821DD9B35" modified="2021-06-02" version="1">MLLRLHAPLVLPCDPECSVLRDAVVDVVDGRIAHVGPRADAPEFAGEVREVTGILLPGLVNTHAHSPMVLMRGLGGDLPLLRWLREAMWPAEAKLKPADIRTGQLLGAVEMLRNGVTTSAEMYFHGEQLVDAVLAAGSRVLFGAAIMDLPGLPWRPMTDEITRWIDADGLRFGPHERIELSYGPHSAYILTPEALGEVADEARDRGALLQIHVAESPEEDLAQRESHGSVPRLLEAAGVLGGRVLSAHSVHLTPEDVRIYAKHGVGIAHCPGSNTKLASGIAPLRSYLDAGVAVGLGTDGPASNDDLDLFEEARLAALLSRVTTLDATAMRAADALLLATRGGAAALGRDDLGALEPGRWADIVHVDVDDPAFATGLDASDDQLLANLLWATGTRRVKDVWVAGEQVVEAGETTRVDRHEAQAGVREVAKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZA9</accession>
    <name>A0A7W7WZA9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerol transferase MdoB-like AlkP superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4969122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="66" mass="6857" checksum="9E5CA27B5B89C40B" modified="2021-06-02" version="1">MTIPSDVLPKIIYAVVVIAYLAFVAFVVWRLSDKVPGTMGRLLVAVGAVMAGLPPILFALGAVMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7WZJ9</accession>
    <name>A0A7W7WZJ9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excisionase family DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="63" mass="7008" checksum="C2473036F5490761" modified="2021-06-02" version="1">MTPDVQPRWYTVAQVADLLGYGLSKTKMLVATGQIRSLKDGGNRRILPGWVDEYVSRRATEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7X033</accession>
    <name>A0A7W7X033_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_006825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4969466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="185" mass="20061" checksum="AD49A07C37EA6DA4" modified="2021-06-02" version="1">MTLPDTLLIEQPWGAGRHLFGTRYRIDVYTEHGAQVAQVTDRGLLGPLRKALRATGFSGRTTFDLVVTQGRQPILRIRKGPGRPPTTVSYPDGRPIGSLRKEGRAHYALLDAAGQRLCHFGDVVGFSTGSITKRDGRRVRQDLLRVRPGVPEPVRTLAIATALAFDVVRGTGTAHTSGGVLDFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXP1</accession>
    <name>A0A7W7SXP1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9572" checksum="616FC36558887EB8" modified="2021-06-02" version="1">MRTYDRMGVHIEQCDGCRGVFLDYGELEAITRLEAQTHTPPPPPPAAHAPAPQVHYVQTQPAWGHGGYGHGYGHRKHHGLAGLFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXQ1</accession>
    <name>A0A7W7SXQ1_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">F4559_000215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4962856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="54" mass="6467" checksum="7A387399FED4D787" modified="2021-06-02" version="1">MAATDVRPKITLACEECKHRNYITRKNRRNDPDRLEIKKFCPNCKTHKAHKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SXW2</accession>
    <name>A0A7W7SXW2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Membrane-anchored mycosin MYCP</fullName>
            <ecNumber evidence="14">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_000283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031570453" evidence="12">
        <location>
            <begin position="27"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="13">
        <location>
            <begin position="97"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4962924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="49981" checksum="279C908AADF65731" modified="2021-06-02" version="1">MHRTTKKLTAAAAVALTLVTTPLAQAQPTTTTRPGVNSVPPKLEPGLRPPAAKPAPDVPYEKKKTCITSDTKDRPLPQKPWGQMQLRLEEAHRFATGKGVTLAIIDTGVNASHPRLAGRVTGGGDYVANEGGTVDCDGHGTEVAGVAAASRDEDTGFVGAAPDVKVLSFRQTSSYYTYEDKANKANSRPSAGRVQTLAQAIVMAAEAGVGVINISLTACEKPREPSTQERQLQAAIDYAVNVKDVVIVTAAGNYNSNDPSCNIQNDNQDSSVVNVVASPPWYANDVLSVASMNREGQPSSFTVWGPWVSVAAPGEEITTLDPAGAGLTNANVDERGALIRIQGTSFASPYVAGVAALVRERFPKLTAHQVMDRIKATAQHPGNPGGRDHKIGAGMVNPVAALTAELPMERTDAKPADPDQMITNLDPLDPPNRTPMIVALAGTGAGVGLLLLTLFVVHTVNRNRNRAATPRRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY07</accession>
    <name>A0A7W7SY07_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="484" mass="54095" checksum="7A851846AB84B491" modified="2021-06-02" version="1">MPLDPHQYRELLSATLPSAFDADTFEPHVRTLFTPDSHRRALDPDATVVKGGRGVGKTVWFKSLQDEELRRLAAAEYRLPRLTTIRALPGYGTALLPDRYPSQRTLDALTTEFADAADIWLTVVLHAVGAPDINAIDNWADRVRWLLAHPEAAERALAHADQEAASTGTTPLFLFDALDRLHSRRDITDRLVEGILRVALDLRTRTRNLRAKVFIRHDMFDGIRLTFPDASKLTANAADLTWSPPSLYGLLFHQMGNADHALSDDFIAETGGWNSTEFRKAPPHWLTSDHEQQRKVFERMAGPYMGRDHRKGIVYTWLPNHLTDGLGQVSPRSFLSALRKATDVTGERFFGHEYALHWDGIRQGVQTASGIRVVEVREDIPWVSTAIVPLGGLQVPIETQDVIQRWEERDLKGELIRLSEATPSADGGAPAPTGPLTTDYPKLIGELVELGVMSRRANGKLDLPDVYRIAFDLGRKGGVPRVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SY84</accession>
    <name>A0A7W7SY84_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_000235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1277"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4962876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="1690" mass="176009" checksum="AA1688215D37AA88" modified="2021-06-02" version="1">MGMELPAELHWLAWIAGGDWPEGDETKVALLADAWERSAQDIETTLRDADAAAKQAMSHMDGAAAKAFEEYWAKVSQGEDATLPKMKHVSEELAKACRNCAMQIEYAKLSTYVAIALLAIQIAIMIASAVATFGASTAGIVPAQLATRAAVQMIYRRLVQSLMQNMGRRLIGRIAMNVGMEVVTSVATDLGVQAFQIMKGTRESVDTKLTLDAAKSGAISGVIGAGVAEGMGKALGDGVGDGLAKSVARNAGEEAVTGGLSSVAEGLMSEEGLKLEDVVQGTVSGGVGGAVGGTKAHLDGMRVDVPDLSSTPDLSASPASSSTADVPRPVRPSDTTSASYAAPTADVPTPSLPGTPGQPGSSAQEADGPTRTAASAFTAPDRSAGMPGGVAPPSTSTVAPSGPPQDRASERSAPPGQASPGAAQPGASTPNRGVPTGPTSASPGSHTQAPAHQAGPTPPTTAPQAGSHAPAQQAASPTSTPHAPAHQASSPAPAHQATPPAQASPHPPAQQATSSAAAAHTATPQAPPSAPPQQPSTHAQHAAPPAGPHTPGTTPGPQSTGTTPNSAHSSPSGHAQPDARHETRAQGSTATAPPITPTTGQPTGHGTPTGGPTPGGQPGMRPVPPDHAHPPRPLSTPAPRPMPPTGPPTPTGRPGPATPDAPGRTAPAHTPPAAGHRTAPNAARPGPNALPARTDTGPRPASTGLPANARPGTPPPARPVPGNRPATPGIGPDGPPAAHSDAAPRTRPDAASHRAAQPDAAQRQPTRPDTALPGATRPSTAEHRGEPGRPWQPPEVDARPARNAVPTEAPLSAEAKAQAFLDEIKRLNRPVPLPDGLGHLSRAVSFSPAGLSLYDNANLSVKRSAQQVAPDPDRYTVDLHGSSGRVRVGEHDLTPEQLAAIIRSSGDWDGTKPIRLVSCQTGANGDGFAARLARELGVDVVAPNRDAWVDESGNVFASSASFDHRAGDFTPGWPPDGAWSTFRPDGTSTPHGEPTPPGHTPTWGDKVPDDKPRAWRRGEPFMPVWGNGTHNAPNAFQPMPHQGADRHQNRPPWHDQDWQNPAGWNHGPDPRALPAPTGHPGFGSGPRIGPPPGPRIGPPPGHDSGFAPPPGFGPRTGGAPDTGFGPGPARHHDQGYGTNPSRTHNPGHGTNQAHNPAYRTNPGQGFDPARGFGQGRAHGMSGGGTAPNTGQQVPSPANRRPDPNAGQSSYRPLSPPDGRGHQARPGQDRHDNRRQPPRPSPQQATYPQGNRQPPPGRGWTPDPRQGHGQPAFPQGRHRPPVQQPPQRQPFRAPDPAPPPRQPLAPQPPDGQQQFRQPQPFHGQPQQPTHPQPQAGRPDPANTARQWNQPTAPVAAEPARVTPAGTPRKVTDDGLEWVHTRQQQLTGDLSKAEIALRDQAVRHYMAERGVDEATAREENTSSVVASDGRFVQLPPRPVPIDELYLDKLAVYVEMRGSSSVPFPDFDPDLPLPDHLPLSVTLPTQGMHDAPAMGRDTIAEGLAADNHGVRPVWRDQPDWTAPENAVYRRDGRSFAKVIADGGLLPHGTDLNIDAHVLGATRNSGFTSFTKSLEDLVARDSQKDAELISGGEEEGFEVRLEYVYEAYHPHGIDVDATRRMAGDTTSNHQESEVVFPGGIDFKYVARVFPVHVTYRKGPDGLLKEVGTKFQPAIENPNFIGARTGRPGTPERPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYE0</accession>
    <name>A0A7W7SYE0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Imidazolonepropionase</fullName>
            <ecNumber evidence="1 4">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hutI</name>
        <name evidence="6" type="ORF">F4559_000612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1 4"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="56"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4963253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="386" mass="39928" checksum="F4AE850F77239C71" modified="2021-06-02" version="1">MTSTVITGIGELTTHSPLGRLSDAALVLAEGRVAWVGRSADAPDADVRVDVGGRAVLPGWVDSHTHLVFAGDRTAEFEARMAGQPYTAGGIATTVAATRAADDDALAANLRRLADEALAQGTTTFETKTGYGLTVADELRAARIAGVFTDEVTFLGAHLVPPGTDADSYVALVAGEMLDAVAPHVRWADVFCERGAFDEDQSRTVLTAAARKGLGLRVHGNQLGEGPGVRLAVELGAASVDHCTYLSAADVDALASSATVATLLPACDLSTRQSLPPGRALLDAGATVALAGNCNPGSSYTTSMAFGVTTAVLQMRLTVEEAVYAATKAGAIALRRDDVGHLDVGARADLQVLDAPSVTHLAYRPGVPLTVAVWQRGERVVRPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SYZ2</accession>
    <name>A0A7W7SYZ2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="134" mass="14698" checksum="8D8EDDBF014A0C25" modified="2021-06-02" version="1">MTLVEEIYVEDSLGVASIELPKGFKPKRPHGMLVGVTAQWVASASDDDRRAVVAAVIRALPGVVDPCDEENFLRQVGSDQWWLGQVVLRLEYRDGEILLLPGSDGDFLHVVHPADSRDVSTVVTEVLRRYASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZ72</accession>
    <name>A0A7W7SZ72_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_000909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4963550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="333" mass="36230" checksum="5CBFD910C7ABDC9F" modified="2021-06-02" version="1">MSEEHIDVRCDTEDLIAGLPHLIGFYPVESLVCLAVRGDRMTWVMRLDLTATDRQIAAAVVTRLQSGGCDSMVAVVVGDHHATRRHHDRVTALAEVLSLLDMSLEGFGVPEVAAGAEWFSYDDPSIGGALPEPGGTRIAMLTALRGYVTYPDRDAMRALVAPADDATLARRAKLIGEAERRWDEVAVDAWPGRPDEPCTRADKLALVTAQVDAVPERSTPLTDGEIADLAWALSDMEVRDACFALVVGPRARDAERLWSELIRECPPPWCAEAAVLFGVSVILRGDGVLATFALERAQTAHPGHRLSHLVVKAMAAGMSPDRLRSYFSDRTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZE4</accession>
    <name>A0A7W7SZE4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 acetylase RimI-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="148" mass="16444" checksum="3174521B070672F2" modified="2021-06-02" version="1">MLDGMELDVRALDIDEWPVWRTLRLAALIDSPDAFEASYEYWAQADEERWRKRLAKPSLNAVATLDGEEVGMVTGSPIEERVELLSLWVAPEVRGQGVGDALVRTVVEYAGRRPVSLQLAESNTHARALYLRNGFVEVAPGVLVKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZK8</accession>
    <name>A0A7W7SZK8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000152</name>
        <name evidence="3" type="ORF">F4559_000895</name>
        <name evidence="4" type="ORF">F4559_001235</name>
        <name evidence="5" type="ORF">F4559_003618</name>
        <name evidence="6" type="ORF">F4559_004876</name>
        <name evidence="7" type="ORF">F4559_005155</name>
        <name evidence="8" type="ORF">F4559_005946</name>
        <name evidence="9" type="ORF">F4559_006801</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 10" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4962793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4969442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4962793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4963536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4963876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4966259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBB4969442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="184" mass="20048" checksum="981AAB48EB5A8971" modified="2021-06-02" version="1">MARFDLTDAEWALIEPHMPVAATGPLPRRVREQFNGILWRFRTGSGWRDVPERYGPWSTVYSRFNTWAKTGVFQTLMEALIAEAASRGQVDLELVSVDSTIVRAHHESAGLAVTGETLDALEQALTGEKGAPLPVQRSVLRVVRRGPRRTRPTRAHLPVGTVPPVGAVGRRGLRRPGSAGPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZL0</accession>
    <name>A0A7W7SZL0_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ORF">F4559_000940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="275" mass="29256" checksum="3395A98749579679" modified="2021-06-02" version="1">MTLHAASRDALAAAELRLLEVLDDTGNATVVDGLGEELFAVVDLLTGQIALRRALAENSSEPESRERLLRGLLDGKVSAATLQVLTTVVTARWSSPRELVDGIESLARTTLLVRAERAGRLDAVEDELFRLGRIVAGNHELERALTDAGAIGAGKVALVDSLIAGKVDDVTKTLVDQLVRAPRGRSVVVGLGELAALAAKRRERSVAHVRSAVELDAAQQDRLEATLTRIYSRPIALHVEVDPTLRGGLLIKIGDEVIDGSVAGRLAALRRDLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7SZN6</accession>
    <name>A0A7W7SZN6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="14">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alpha-IPM isomerase</fullName>
            <shortName evidence="14">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">leuC</name>
        <name evidence="17" type="ORF">F4559_001228</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="14"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047508">
        <property type="term" value="F:(R)-2-methylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBB4963869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="467" mass="49837" checksum="BB391F9C8861DFD8" modified="2021-06-02" version="1">MSRTLAEKVWEAHVVRHGSGAEPDLLYIDLHLLHEVTSPQAFDGLRLAGRPIRRPDLTIATEDHNVPTVDIELPIADPVSRTQVETLRRNCAEFGVRLHPMGDFEQGIVHVVGPQLGLTQPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVMATQTLPLRPFKTMAITVDGSLKPGVTAKDIILAVIAKIGTGGGQGYVLEYRGAAIEALSMEARMTVCNMSIEAGARAGMIAPDETTFEYLKGRPHAASGADWDAAVEYWKTLRTDDDATFDEEVRLNADELTPFVTWGTNPGQGLPLGASVPDPETIGDENERVAAEKALAYMGLEAGTPLRDIRVDTVFLGSCTNGRIEDLRAAADVLKGHRVADGVRMLVVPGSMRVRAQAESEGLHEVFLAAGAEWRQAGCSMCLGMNPDQLKPGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T058</accession>
    <name>A0A7W7T058_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein YjjB (DUF3815 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="12500" checksum="08D52E05134DF401" modified="2021-06-02" version="1">MAKWVWPVATGLVTSATGVALNLATDLRDEPVSWIAVVVLTALGIWVARRSRSHEIVSHAPAVVVGSTTVSNDVPGVVNGNAVQGVTVGPVTFNPTTNIDQTAVAHDGGTVHQAGRDINGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T089</accession>
    <name>A0A7W7T089_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative MPP superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_001581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="580"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4964222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="806" mass="83739" checksum="6EBA94016A5E6DD0" modified="2021-06-02" version="1">MLFVLLFVVVLGAVHYYIWRRVVRDTTTSVRGRRIGTVAVVLLYALMMAALLSTRAGVGGFLAWPGYLWLAVAFYLALLLGVLEIPRYVLLRRLAARERAGAHEAISRTAPGTQSHGVPDTGTETETRTASDTRPSTDTRPGTGTRTAPLTRSHAGAVTELLTRPQTDTRSDPDADPGNATDSRKAAGTDPRTGAMVDFTAGHPTEAGTTPAGLASADAKAASSTNTRNGPSVRFESHAEPDIDTGPRTAPNADTVPRHEPDRDTGARHEPNRDTGTRHRPDGDTRPPTDQVTDTRPHADLDHDAGPRDDHDNGSPLGREPGTEPTLDAEPRHGAEGGTGSNRSTVGDDEPCTNTDRDTRPRTKAGDDTGPHAGMGSDPGTRTDIPIANDVGTADGTGDDNGSGDGAGHGSGLGGGAGHVNDPCGGTRDGNGLGGGTRDGSGLGGGTRDGSGSGDGTGDTVDSRNEHESGRDDSDAIRDTKDDTARGTETADGNGSGATGTGAADGSDTGTQAGTDADTGAVATPDVGRRLFLARTLAVVGGVAASGVVGYGMTEALGDPVLKRVPVTLDKLDPRLSGYRIAVVSDIHLGPLLGRAHTERIVRLINDMEVDLVAIVGDLVDGTVEELGDDAAPLRDLVSTHGSFFVTGNHEYYSGAQPWLTELERLGVNPLRNERVTVERAGARFELAGVNDLNGRQSGDGPDFGRALDGRDATVPVVLLAHQPVQAREAAKYGVDLQLSGHTHGGQMFPFHLAVGLQQPVRSGLATVDGTQVYTSNGVGFWGPPVRVGAPPDITSVELHHNFAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0A4</accession>
    <name>A0A7W7T0A4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030702950" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="53" mass="5792" checksum="64925880BC7D27AB" modified="2021-06-02" version="1">MNIKKVLTLAAVALVLFFLITQPDQSAQTVKGILGWLRTGAESIITFVRSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D5</accession>
    <name>A0A7W7T0D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="52" mass="5999" checksum="1A1BD7E4B5C77D30" modified="2021-06-02" version="1">MRRTRGRAELGRLRREAGHDVDDTRLAYHRALCYLPPSGWAHSSTLYEIETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0D9</accession>
    <name>A0A7W7T0D9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="262" mass="29137" checksum="5978E107B6D16E95" modified="2021-06-02" version="1">MKVGQRKTTGRFLRHAVEMVVAMLVGVELLAPAWEWAGQRPDVVALVTATDMTVAMALWMRYRGHPWPRVVEMGAAMFLPYLVLLVPHWLGVLDGEHVLTGGHVLMLPAMVAAMLVHREEYTRPHGESDAHPLVKEVGRRGPTWIALAMTFDQWTEPLVPWPVALLVLPGAYLVFGMAKGHLRDRRVLAAQLAGLVAYAVLAVVASNADPRMAAWLVAAGWGLHAVWDVVHHRLDRVVPRWWAEWCAVVDFVVAATILSVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0H4</accession>
    <name>A0A7W7T0H4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_000374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4963015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="259" mass="28370" checksum="B24031E64EDA9561" modified="2021-06-02" version="1">MRLYARLAAAGFRRHSTYRQAMLAGVAANVVFGFLRTAILVAVVSSAGTVAGYDVPAAVSYVWLGQGIIGFINLWGDTELGERVRSGDVVVDLYRPWDLQAALYAQDVGRAGFTALIRFVPPTAVGAVFFPFHWPDAGTWPLFALSLALSLTVSFGVRFLVNLSTFWLLDNRGIMSLYNALVWVMCGLGLPLAFFPDWARTLLWCTPFPSTLQAPVDVYLGHGPQWITLAHQVFWAVALILLGRLVLARAVRRVVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N3</accession>
    <name>A0A7W7T0N3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021522">
        <property type="entry name" value="MctB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11382">
        <property type="entry name" value="MctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="316" mass="31334" checksum="FFCC84FE312697CD" modified="2021-06-02" version="1">MVRVITLRYHIVSITAVFLSLAVGVVLGSTAISGRLLSGLTEDNGSLGAQVADLQNQRNALDARLADQDRFAAAIGPLAVKGVLTDRTVVLVTTSDAAPGDRDALAELLRSAGAAVTGELQLTDAFPDPGKADQLRDLVARLQPAGTELPTATDPGTRAGGLLGTLLLLDAETNEPQASADETAAALAGLAGGGFVKSGSDLKPAQLVVVLTGGALTADSAADRASTLARFATQLDRSGVGAVLAGSAGSADGTGPVGVVRADTAATSVLSTVDDVGTAAGRVVTVLALREQLDGKAGRYGVAGNAQGPAPGIEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0N6</accession>
    <name>A0A7W7T0N6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_001792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043917">
        <property type="entry name" value="DUF5753"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19054">
        <property type="entry name" value="DUF5753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="282" mass="31545" checksum="6A28F8DC665CB864" modified="2021-06-02" version="1">MPGNAYTSVRSRTVATALRLYREERKLSCEDVGDVLGVSASKISRMETGKSGLQYEDVNTLLGYYKVPPGRRKELLDLVRKGEETGWWERQPGLPRLWRKLIDLEHKAVRVQSYEAMIVPGLLQTAEYAQALLTAVDPGLSEREVDTLVSARMARQTLLTRAGAPRYLAVVHEAALRIRVGDGGVMRRQLRRLLDAGERPNVDVVVVPMAAGSHVGVRGSFLALEFRHEPELVFVENQDTGIFVEDPAELTRYHRALRTLREVALDAEASAARIAELTEEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0Q9</accession>
    <name>A0A7W7T0Q9_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030854492" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="62"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="302" mass="32331" checksum="CD308910B8E9A4CB" modified="2021-06-02" version="1">MRWVLLVALLLMSACRNDAREVAIDDVPPAAQAGATGNGASTGTVTEDCGTNAGRHLNADNIVSAPGKPFGAHHTHEYVGNTSTDHASTDDSLAAATTTCPDDDRSTYYWPVLRLTARTGPDHHAPGGGEHGNTGEVLPPGRVGITFTGNPASHVVPMPRFLRLITGDPSARTTGQSTAKWSCTGFEDRRTGRYPVCPADSDVVRIFEFPSCWDGRNTDSPSHRAHLVFPGADGVCPPRTFPVPKLTVRVVYDVPEGEPFAVDSFPDQDRDPRTDHSMAVNVMTDDGMRRVAECLNSGRTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R2</accession>
    <name>A0A7W7T0R2_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="188" mass="20658" checksum="FF9E185975D19FB2" modified="2021-06-02" version="1">MDLSPRALFSFARTTVTTTVPSLVVTAASVPGRVLDLLQAAEDVVRRADALVDRTERVLEETEMVVGRARVATAAAEQVLTDASTAARTSRELVDDYAPLARQARPLAKRFVDELSPQEVDAAVELVDRLPVLTRHLIEDVLPILATLDRVGPDIHQLLEVTNDVRQAILGIPGFAFLRRRGEDREDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0R3</accession>
    <name>A0A7W7T0R3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSer/pThr/pTyr-binding forkhead associated (FHA) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_001812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="152" mass="15947" checksum="962E35D0ABF44303" modified="2021-06-02" version="1">MSTNDGPGVPPEQSPERTSVFRADFLAEVEGAETPASEPAVAGVDALPAGSALLVVKRGPNAGSRFLLDRDTTSAGRHPDSDIFLDDVTVSRRHAEFRREGGEFVVIDVGSLNGTYVNREPVDQAVLANGDEVQIGKFRLVFLTGPGAGGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T0S5</accession>
    <name>A0A7W7T0S5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_001820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4964461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="290" mass="32740" checksum="D1439E90A64061F0" modified="2021-06-02" version="1">MGVVLPESAWTARRAAHVDRVRRWTGPHHERKAQGEKHPVLDFLFSYYSHRPARLERWHPGPGVVLAGDAAAEYLRWPAYRRTDEGVTLDVAAFREDRASTIDFVHRLLTATAARAPRLGCFGLHEWAMVYRQRQEDVRHNAWPLRLGAAGTNAVVEEQTVRCGHYDAFRFFTLPARPLNTLTPTRETQVDLEQPGCLHANMDLFKWSYKLDPATPSDLTADCFALALRVRELDMRASPYDLSALGYEPVRIETVAGRAEYVRLQSAFAAEAARLRSALVDVTSALGDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T192</accession>
    <name>A0A7W7T192_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase subunit of ABC transporter with duplicated ATPase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="336"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="542" mass="58839" checksum="AA9141B0714A3371" modified="2021-06-02" version="1">MITATDLELRAGSRILLSDATLRVQPGDRIGLVGRNGAGKTTSLRVLAGEGQPYAGEVRRTGELGYLPQDPREGDLSVIAKDRVLSARGLDQLLRDMEKSQSTMAELVDDAELAEAVRKYGRLEERFAALGGYAAESEAARICSNLGLADRVLAQPLRTLSGGQRRRVELARILFAASEAGVGAKSSTILLIDEPTNHLDADSIAWLRGFLKSHDGGLVVISHDVELLDDVVNKVWFLDAMRGEIDIYNMGWKKYLEARSADEKRRRRERANAEKKAGALMAQADKMRAKATKAVAAQNMARRAEKLLAGLDEERQSDRVAKIRFPEPAACGRTPLTAEDLGKSYGSLEVFTGVDLAIDKGSRVVILGLNGAGKTTLLRLIGSMEKPDTGRVVPGHGLKLGYFAQEHETLDHNASVWQNIRHAAPDTPEQQLRSLLGTFLFSGEQLDQPAGTLSGGEKTRLALAGLVSSAANVLLLDEPTNNLDPASREQVLDALRRYEGAVVLVTHDPGAVEALEPERVILLPDGAEDHWSDEYLELVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1C4</accession>
    <name>A0A7W7T1C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase (NAD+)</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043878">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="16"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4964734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="475" mass="50060" checksum="2CEA882066691EC7" modified="2021-06-02" version="1">MSTPYWVAGRPVTSDDVVEVRSPHDGALAGTTSQATAADVERAVAAADAVAAEFALTPAHVRAAALDHVSRRLAERITEVAALISAESGKPVKWATVEVNRAIATFRWAAEEARRFSGELQRLDTEPASDGRLALVRRVSRGPVLGIAPFNFPLNLVAHKVAPALAVGAPIIVKPAPATPLISLLLGELLAETDLPEGSWSVLPVPNEVASELVADPRLPVVSFTGSGPVGFAILERVPRKHVTLELGGNAAVVVAPDWSDLDWAAERIATFSMYQAGQSCISVQRVFVHRDVYQRVADAVVENVRKLGLGEPSDPATDVGPLINEAAARRVETWVREAVDAGATLLTGGTRDGATVTPTVLADVPAGCKVVDEEVFGPVVVLDVVDSVEEAFGKVNSSRFGLQAGLFTHDVRLAFKASARLEVGGVIVGDVPSFRADQMPYGGVKESGIGREGVRSAMADLTEEKVLVLTGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1C6</accession>
    <name>A0A7W7T1C6_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="231"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4964762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="455" mass="47968" checksum="A38A02990C7961D7" modified="2021-06-02" version="1">MAQGYRQGADTGLDPESWRRLVDGFDEAVVVVDPAGVVRLANPLAATLFRPGMPEGRRLDLGGGWTAWFRARADFLERASQRLAVLTDRAETLHAIVELAPADHAVVVVPGSRGRLEWWRRTAAGAQVGRTTRQAASAVPGLAEALAGVPGPVEVDALGDLPWGATEAPGVAVSLGGGGALVLFGAGDAELTRRFAERSAAALDAAVRFGERERTVEVLRAPLLPPALPEIAGVRLARLYEPAHRRDLVGGDFYDVHPREDGGAVFVLGDVAGNGLDAAVHAGRVRQSLHTLLLVEQRPARLLALLDTALRAAGSRLFTTLVAGSLVPVQAGGLRLVLAAGGHPAPLVLRADGRVDEIAVHGGIVGVLPEARFNQTAVLLAPGDTLLLYSDGVTEARAHDDRQELFGDKRLRTALADCAGLPAEAVAEHLRRVVFGWLGDAEHDDVTMLVVQAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1K6</accession>
    <name>A0A7W7T1K6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_002227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="114"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4964868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="446" mass="49069" checksum="2A6C8585A80703BC" modified="2021-06-02" version="1">MLTVGELRGLVDSGTVDTVLVAAVDMQGRLQGKRCAGRFFVDEVLAHPAESCDYLLAVDVEMNPVGGYALSSWDRGYGDFVMRPDLSTLRRIPWHEGTALVLCDLEREDGTPVEPSPRRVLRRQLDRLAARGLRADVGTELEFLVFDDTYEDAWDRRYRDLTPANRYNVDYSLLGTGRVEPLLRDIRNHMAGAGLRVESAKGECNPGQHEITFRYADALVTCDNHSVYKTGAKEIAARHGRSLTFMAKYNEREGNSCHVHLSLRTDDGRPAFADEGGMSAPMRHFLAGQLAALRELTYFLAPNVNSYKRFAPGSFAPTAVAWGRDNRTCALRVVGRGAALRFENRVPGGDVNPYLAVAALIAAGLHGLDRELPLEDAFVGNAYAADRATVPTTLREAASLLAGSAVAHEAFGEDVVAHYLNAARVEQAAFDATVTDWERIRGFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1R7</accession>
    <name>A0A7W7T1R7_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_001109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4963750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4963750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="511" mass="56137" checksum="666B1B3A35E39A1B" modified="2021-06-02" version="1">MITVTDLFCGAGGSGLGATAVPGVQLVMAANHSPRAIETHAANFPDCAHDCADISQVEPRRYRRTNILWASPECTSHSVAKGRKRRQVGPGLFDEPLPDHVAERSRATMWDVPRFAEVHRYDAVIVENVVDAAHWAPFQAWLMAMDSYGYDHHVVYLNSMHAPAIAAPRAPQSRDRMYVVLWRRGNRRPDLEIRPRGWCTGCAAEVECRQAWKRRGATWPLERWGRYRAQYTYACTTPGCGRPVEPYVLPAASAIDWSMLGERIGDRDKPLSDKTIARIRAGLARYAGAQLVPSGGTWNESAQPVTGPFRSRTTRENEGLLVPVEGRVGNAALPAAAPMRTQTTRHETALVVPYYGTAEAAQPTDRPLGTLTTVDRYGLAFIAELRGGGSTARDVREPLSTVTASGTHHMLVRHNTARGDEGYLSTPVDEPMRTLTTAGHQSLVGWSERPPAVEDCTFRMLAVPEIQRAMAFGDDYVVTGNKREQVKQLGNGVTPPAAEFLIRAVVDSLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T1Z8</accession>
    <name>A0A7W7T1Z8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kef-type K+ transport system membrane component KefB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_002452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="16"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4965093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="418" mass="42753" checksum="5ED431964AF490C6" modified="2021-06-02" version="1">MDISLSIAHAAVVLLVVVGLAALGRRLAAFVRQPPVVGEIVVGLAAGPVLVALVGRDVFAVLLPVDVRDVLKVVAEAALVLYLVGFTRELRIGPAAPDRRSAVLVSFGALVPPLLCGVGYALWLGTDEALRGRAPAPAFVVCVAVTLAITAVPVLARLLTERRLLDTPEGGLSMTAAVVVDCVGWLLLSLAVALSRGERGFFLVAMAVFGGGLVASVVIRLVLRGGVATRLCGRWPRVAALALGVLALVVGFGVHGLGLTAVFGAVLVGLAVPGGRDWDVPVRTVTRVGGPLLPVFFTSAGLTALTGTLGSLPVPATLLALGLAFVGKIGGGYLGTRMAGRDHRLSVRVGILLDTRGLTELVVLQVGHQAGILTPPVFLALLVMAVVTTALTGPLLSLVDRVPFRVGGISGKRDGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2D5</accession>
    <name>A0A7W7T2D5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase InsO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_002691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="135" mass="14536" checksum="7F4846B65B0865B4" modified="2021-06-02" version="1">MIDLHNREVVGHAMAEHMRAEPGALDLAVRGGLTGDGAIIHADRGSQHTCGPFRCTLTGHGIGPPVGRTGSCFGSFFATLKTEIGTTVRESRDDARRDVLACPGYRNHDRLHSTLGYRTPHEARVGRRRGVALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2M6</accession>
    <name>A0A7W7T2M6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxypropanoate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_001574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02148">
        <property type="entry name" value="RutE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023936">
        <property type="entry name" value="RutE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4964215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="202" mass="22033" checksum="9556DFAB37016D86" modified="2021-06-02" version="1">MSASLDTLALSPEAQDLLFTGARTANAFTDEPVTDEQLRQVYELVKWGPTSMNNQPLRIVYVRGEGSRERLLPHLGEGNRAKTASAPVVAILAADTSFHEHFPRTFPHFEGARDLFADKLDVRDSVARLNAGLQIGYFILGVRAAGLAAGPMSGFDAEGVRQEFLADTTLQPLVIVNIGHPDHSGTFGRLLRLEHDEVVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T2Q5</accession>
    <name>A0A7W7T2Q5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="entry name" value="PTHR38847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031305045" evidence="1">
        <location>
            <begin position="23"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="206" mass="21584" checksum="5B52787A6B059A20" modified="2021-06-02" version="1">MLNTATAAVLALSTVAPVHRVADPPLHVDLVSAVGSGCRGAFVGVAADNRSFEIGFGDFVALVDGHRPVDRKSCRLGLRIVLPAGYTYGIAGATYRGYVDLRPGAAASHRAKHHIQGGIGLGGVESRFAGPRVEEWQADYAPDLPMIVYAPCGERRDLIVDSELRAALGTSNPATPSGIAADTVADRPGHMVFRLATKACRVIEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T338</accession>
    <name>A0A7W7T338_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="78"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="32442" checksum="CD2ADA127F168FA2" modified="2021-06-02" version="1">MTLDPAVAAMLAATPAPPADAPPMTPAQLRAAFASMLTVPADLPEIGPVTDLSVPGPAGDLRVRLYLPKSDEPAPLFLWMHGGGWTIGSIEENELASRRVAEAGIAVASVEYRLAPEHPFPAAPEDCYAVLAWFARNGAEHGVDGSRIATGGESAGGNLATVLALLSRERGGPRIAGQVLVVPVTAHPSDEGLTSYVDCAEGYGMTADSMRFFFEQYVSDPKDLDDPYLLPSRADVSGLPPALVMVAEYDVLRTEGEQYAEKLAAAGVETTVKCYDGQIHGFYGLYTDLPISPVSHADVIAFLKSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T383</accession>
    <name>A0A7W7T383_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ABC transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_003141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="239" mass="25277" checksum="8781F65F60B1428C" modified="2021-06-02" version="1">MTALQLHELRKAYGTVRALDGVSLEFPAGTFTAVMGPSGSGKSTLLHCAAGLDRPDSGRVVLTGVDLGTLDDDGLTVLRRQRIGFVFQAFNLMPTLTAEQNVELPLRLAGERPDPAAITAALAAVGLADRAGHRPAQLSGGQRQRVAIARALTTRPQVLFADEPTGALDSHSGHEVLDLLRALVDRERRTVIMVTHDPVAAAYADQVVFLADGRLAGTLPRPTAEAVAARLPKLEARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3F8</accession>
    <name>A0A7W7T3F8_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="11" type="ORF">F4559_001994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4964635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="9">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="10">
        <location>
            <begin position="259"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBB4964635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="707" mass="77161" checksum="2C395C9306D05137" modified="2021-06-02" version="1">MADPSTYRPAPGTIPDAPGVYKFRDSGGRVVYVGKAKSLRSRLNSYFADVAGLHPRTRQMVTTAAAVEWTVVATEVEALQLEYNWIKEFDPRFNVRYRDDKTYPVLAVTLDEEFPRLHVYRGPRRKGVRYFGPYAHAWAIRETLDLLLRVFPARTCSSGVFKRHGQIGRPCLLGYIDKCAAPCVGKVDAKAHRAIVEDFCDFLAGKTDSMVRRLEREMTAAAEELEFEKAARLRDDQTALKRALEKQAVVLGDGTAADVVAFAQDDLEVSVQVFHVRGGRVRGQRGWVVDKVDETSVPALVDQFVTQFYGAQAESARVGGVEAAPVPREVLVPELPEDAEAVEKWLAELRGGRVALRVPQRGDKRALMETVERNAKEAFQQHKLRRAGDLTARSAALQELQDALGLDTAPLRIECTDISHVQGTDVVASLVVFEDGLARKSEYRRFAVRDAAEQGDVASIAEVVRRRFQAYLKETAGGGPTPGIDPDTGRPRRFAYAPNLLVVDGAGPQATAASDVLAELGITDVAVVGLAKRLEEVWLPGDPDPVILPRTSEALYLLQRVRDEAHRFAVAYHRQKRSKRLTVSALDEIAGLGQTRKAALLKHFGSVRRLGEATVVEIAAVPGVGRRTAETVHAALNKSAGVPVQDGPAGVHGGAARTSPGDDQTSPDIPAQDEPVRATTAPRVPRQDGSVPDAAVRNGPTTTQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3Q5</accession>
    <name>A0A7W7T3Q5_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">F4559_002846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBB4965487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="71" mass="7351" checksum="8E0BD6BA75A79176" modified="2021-06-02" version="1">MWCVAVDGRTCIGSGMCAAVAPGHFRLDGAVSVPKRTELEPDDVVLDAAESCPVEAILVRDADGTVLAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T3U5</accession>
    <name>A0A7W7T3U5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phosphoglycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="190" mass="20605" checksum="E6D064852B371173" modified="2021-06-02" version="1">MSDWSVLLVGGASGSGKSTLARPVAAARGAVLVEVDDLVLATQAVTTPDSHPDLHHWRRHDADRLGPEGVADGLITVARALAPAVDAVIADRLDAGVPLVLEGDYLLPEHCARWVERDRRVRAVFVREPDADRVRRNYLGREPESGDQVRRAECSAYYGDLLAAEAEKHGLPVFAARPWHDAAERLAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T422</accession>
    <name>A0A7W7T422_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide (TPR) repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4062" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="779" mass="83976" checksum="153ED006A76AA59E" modified="2021-06-02" version="1">MFISHTSELRAYPAGGSFVDAVESAITRAGDVVVDMAYFAARDALPASVCREAVGSADVYVLVAGFRYGTPVRDRPEVSYTEAEFEAASESGLPRLVFLLGEDTEGPVGLTRDLEYGDRQERFRGRLRDSGLTAAMVSTPGALEAAVLHALTSSRRDEPSTVWNVPARLPGFTGRDALLARLSGALSDAGPVVVSAIAGMGGIGKTSAAVEFAHRYADDYDVVWWIAAEDPTLIPAQVALLGQVLRVVEVGDPVEVAVPMVLGRLRGRDRVLLVFDNAEHPEAVAPFLPGGRARVVITSRHTRWDGVAVAVGIDVFTPEESARFVRSKAPSLTPEEVGEVCEALGHLPSALDQATALLSDGTFTPDAYLGLLRTRAKELLHRGHDRVSVTASWSLAFDALAGRHPAALQLLTLVAWPAPEPVPLSLIGDHPEVLPEPLASVMADPLAVADVVRVLRQRALVRADAGSIHLHRVPAALLRGDAADWAVTAFTLMIRNEPGYAWSNPAVWPHWQRLLPHLLAVTAPDRHDLLADHHDALAKLLDGISTYLATSGHAHQAIPHARRAYDLARERQGDDDPRTLRYANNLSIRLKAAAEDRAAREIGADTLARLRRVLGADHPGTLRAAGNLVLGLIESGEHQAARELGADTMARFRRVLGEDHPDTLSSANNLAIALGKVGDRRAAREIFEDCLARCRRVLGADHPDTLMTAHNLAVELADSGDSRAARGLFEEALSGYRRVLGDRHPHTRHCADCLVKVVRHLGDGERADALQAWIDSVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T447</accession>
    <name>A0A7W7T447_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RimJ/RimL family protein N-acetyltransferase/uncharacterized damage-inducible protein DinB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007061">
        <property type="entry name" value="DUF664"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04978">
        <property type="entry name" value="DUF664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="307" mass="34700" checksum="9CF52B048B97FA88" modified="2021-06-02" version="1">MTWLRALDDDALERLLRLAVDDADPADVMPPGWTPDREDEFRAFYRGLRPDVYEIVIRDVGTVGMARLTPDGDFGMWIARSHRGQGYAGETLRELRTYADALWVTTMTARTTPDNTPMIAALRRAGAVPATVDGEVHARIGRGEEPALTLADPATLLRGFLDFHRDTVLRKLDGLSDEALRTPLVPSGWTPLSMVKHLAHVELRWLRLYFAGEDVENPRGNPDVPRAEWVLEEHDTFESVREFYVEQVVRSRRISDAAALDDVVEHWPRAEPAPTLAWILFHLLQEYARHVGHLDIVRELIDGETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E2</accession>
    <name>A0A7W7T4E2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">F4559_003713</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 12"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBB4966354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="923" mass="102751" checksum="7D7AE0101BC70B69" modified="2021-06-02" version="1">MTTRVIRRDGTVSVFDAGKIRVAVTKAFLAVEGDSGHLRPVVGELTAQVEKALLKHVRPEVALHIEQIQDQVELVLMREGHHKVARAYVLYREKRAKAREVTPAPPAFRVKTADGTLVPLDWDRAEVVVGEACAGLADVSAAAVLAEVRRDVYDGITVDELAVAQVMAARTLVETEPDYSFVAARLLLDRLRREALTRVEGRPVEATGEELSYAAYFPEYVRLGIDLDRLDPELAKFDLDRICAAIRPERDAKFDFLGMQTLYDRYFLHDDGTRYELPQAFFMRVAMGLSLREDDREARAIEFYELLSSFDFMCSTPTLFNSGTTRPQLSSCFLTTVDDDLQSIFQGYQNNALLAKYSGGLGNDWTPVRGMGAHIRGTNGESQGVVPFLKIANDTAVAVNQGGKRKGAACAYLETWHVDIEEFLDLRKNTGDDRRRTHDMNTANWVPDEFLRRVEADADWTLFSPDETPDLHDLYGRAFAERYRAYEEAAERGEIRVSKRVRAVELWRRMLTMLFETGHPWITFKDPCNVRSPQRHVGVVHSSNLCTEITLNTAADEVAVCNLGSVNLANHVTPDGLDRDRVARTVRTAVRMLDNVIDINFYTIPEARRSNLRHRPVGLGLMGFTDALFVQRLVPGSAAAVAFADVSMELISYHALSASADLARERGSYETFEGSLWHRGVLPIDSIALLAAERDGLDMDTSSTLDWDALREKVRGGMRNSNTMAIAPTATISNICGVGQSIEPLFRNLFVKSNMSGDFTVLNRHLIADLKARGLWDEAMVADLKYFDGSLAPIDRVPDDLKALYATAFEVSSEWLIEAGSRRQKWIDQAQSLNLYIAAPNGRKLDAIYRLAWHKGLKTTYYLRSTAVTSVEKSTLRGVDGKLNAVRPVAEPVPVPVPVAAPTVTPDDALVCSITDPDCEACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4E8</accession>
    <name>A0A7W7T4E8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_003732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030835739" evidence="3">
        <location>
            <begin position="27"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4966373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="794" mass="80197" checksum="7807C7FED890672B" modified="2021-06-02" version="1">MSGGRSLTALLCVVGLLSGATGVASATLDDAAANSRWLAARLSPDGTLENPLGGALPDHGLMIDVLFALTASGERARAEPIVGYLDGHAKDYFTWDGLAPGSGFDAIIVGGATAKVLVAAQVAGRDPRAFGGYDMVAETLATIRRSGPDIGRISDYTKNPDFADFIGNNANVFGQALGVVGLAAAGASDRPAIDKLVTQQCAEGYFRIFFALVPTDETGDHVTPDGHKVSSCDEGKAFGVSPPDGDATAMGLSALLAARATGEPGLDEPVSRAVEWLRANQKPDGGWGGGVGTEAANTNSTGLAVQALAAAGGADAAVVAGTAFLKSAQVSAADPGPALTDQVGAIAYTPADYQAARTGGIVGVDTWIRAGAQASLGLSRVSFLDLALGRRPSDPPPVTASPTVPAPPPAPPRAPAPVTVIRTAAPAPVAAAPPATRPDTVTGRLAAYLAGGLVGGDHVEVEQDGGRFVDYDATADVVLALRTLGGQDEAVARASRFLLRPESIRAYAHGEPYETGSAYAEPLAKLSIVARFLRADGARDVDGVVDETTRSLATRVRDGDVVDTGANGTPDTTRRAWGITARTAAGADASDARRELAESQCADGLFPVEQHGKPCAKGDLRATSVAAVALNSGPEPSAEVTVALVRAAKALTARTGDDGLVAGPDRRPDLALSAAAASGRQAAGLDASDTARALALFAREDGGFAAEPGGPSDFATSLAAAPGVAGRSWTAVAGAPVTPALRLPLDEGGARATVPVAQALPVWFPPGFAAFALLVAVGFGLRRAVVRRQGRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4H2</accession>
    <name>A0A7W7T4H2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030954013" description="CHRD domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="CHRD" evidence="2">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="160" mass="16498" checksum="4591FC84EE33ECEA" modified="2021-06-02" version="1">MKAALRLVVPVIAALALGGLAPAAASADPLLDVDLDLDLSLLGGGRTHEANLSGPNEVPGPGDPDGVGYAKVVVHRDQVCVALLVRRVDAPTAAHIHRGRIGQAGPVEVTLPAPTSGSVSGCVDVDRDLAQELRRNPGRFYVNVHNAAYPNGAVRGQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4H8</accession>
    <name>A0A7W7T4H8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator with XRE-family HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_003726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="425" mass="46794" checksum="D7BB2FBD2B48B5CF" modified="2021-06-02" version="1">MNDDQIPPAPESAGEELARQIRQRRDQAGLSQPKLARMIGYTRQYISRAERPNHNLPSIDLVRALDAALDARGALMSLREKAKKERTNLHMQNGANGSDLLHTGDPSTDSQDAFDLETRPRWRVGHSEVAHVRLMTSALAASENLYGGGMSGEVASAQLRSARRLLDASATPAIRAELFEAVGNLASVVGYAAFDIGDHTTARRCFDFSLSCADEAGSWELRAATLADLARHSTYRGDFDNALTSIELAHVRADRLTLTTRAMIGSIRARLLAFTDRHNEAKTQLTHADDCFADRHLDPIPAWMTYYDEAEHAGSTSRTATALALTTGEPDDAFHRLETAVSRYTDAYPRSRTFARLQLATLHMRIGDPREAAALGRAALPDATTIRSRRIADELGALRETARRHQVITEVAELAEALDTMDHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4K8</accession>
    <name>A0A7W7T4K8_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032724">
        <property type="entry name" value="DddA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14428">
        <property type="entry name" value="SCP1201-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="15036" checksum="9AD4F65CFC380CCF" modified="2021-06-02" version="1">MEELRREPPPTFERNTGRKTHGRWIAPGGSAQPAVSGHDEWTPKVNEILADQGCPRLPVATSADVELKLAARMRVQRADDPAMRHVSLVLNRAPCEGTLGCDKLLPVVLPEGYTLSVYGPNGYYEKFSGGKSPWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4U4</accession>
    <name>A0A7W7T4U4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="136" mass="14722" checksum="A8B2DD0FC5A796C5" modified="2021-06-02" version="1">MNAELTDRPEPDDRDLGAGRDLPWTPEVERPLPAAVDRVDLVDPEARAIVGHADLRALEGRGTHLVRGVHPDALAHYVDGVINGQVPDVLTKHTTNAGGERITAHWDPDKCALVIQDGDAGTVFTPKLGKEKFDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T4V4</accession>
    <name>A0A7W7T4V4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator GlxA family with amidase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_003670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="224"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="327" mass="35322" checksum="86B7F8A5B6703BB2" modified="2021-06-02" version="1">MGPGSVAVAVLDHTDIPLMDLYELSIACAVFGVPQPELAPRWYDFRLCVEDPGARASGSGFGVRSEFGFDDLAGADTVIVPSVPDECVEGGRGIPPRLVEALRRAHEAGARVVSLCNGAFALAEAGLLDGRRATAHWLHTDVLAARYPEVDVDPDVLYVDEGSVLTGAGVSAGLDVCLHIVRNDLGAHVADQLARRLVVHAHRAGAQAQVVARTVPADVADPLGPALQWAIGNLDRPLTVEDMARRAGMSTRTYFRRVQSATGTTPLRWLLDQRLSRVQALLETTDLPIEVISHRSGLGTAANLRRLFTRRFLLSPRDYRREFRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T533</accession>
    <name>A0A7W7T533_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="296" mass="31047" checksum="019F7F384F337D30" modified="2021-06-02" version="1">MTDVDGSMKVFLTALECERDAVLAHLVDVETRSHGNGTVFDVGRSPSCPGFSIAVGCTGTGNLRSGTLTERALAMFSPSFTVFVGIAGGLKDHLELGDVVAASKTYAVHGGRSQDDGFRARPQSWEVPHVVEQVARRIKPAHWHGLLSDEGRALAPRAYLAPIASGEVVLNSRTSPLALQIDRNYNDAAAVEMESAGFASAAHANRGALVATVRGISDHADGDKEQADGQGSQETAAANAAAYALALTAALHVSEGHAAESARRRPELPGIRNTNVAKGRARVGQQIGVVLDGWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B3</accession>
    <name>A0A7W7T5B3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flp pilus assembly protein TadG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_004228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4966869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="122" mass="12068" checksum="E8CD3EDFD65FD620" modified="2021-06-02" version="1">MLLVFVGVVIHRGVDARIRIDDAAHQAARAASIERTPTAATTAAQSTAASALSSAGVTCASLSVSTSTGGLRPGGTVSVTVSCAVDFGDALILGLPGGKTLSATSIEPVDLWRSTLNTGSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5B4</accession>
    <name>A0A7W7T5B4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flp pilus assembly protein TadG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4966868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="149" mass="15517" checksum="3F4C84168ED97D5A" modified="2021-06-02" version="1">MSHKHNTRSRATRAGWCRVRRALRGDRGSVSAELVIATPLLLLMLLAIVQFALWSHATHIAQAAASQGLAVARSQNGTAAAGMSSARQLLDQLASGPLTDSTVASDRNAASASVRVSGTATSVVPFLSLPVHAEAVGPVERFVPDLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5C7</accession>
    <name>A0A7W7T5C7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_002939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4965580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="102" mass="10208" checksum="B3146561EA606AD0" modified="2021-06-02" version="1">MTSSSPSAVGVPDAGSDGPPAGVDHVVDQAVDAVDRARAVLRASGDPVLAAVDSALSCAVSLIALRQRGPDSDIDPLQDALGAARALVGEVTFAVRDSYGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5G7</accession>
    <name>A0A7W7T5G7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YndB with AHSA1/START domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030668775" evidence="2">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="20506" checksum="45C56B88B03EE7EA" modified="2021-06-02" version="1">MPAARRTAALALALVAVLGVAAPPAQAGRGPVTCQGQGVDPDAEARHRAETLVHAPLRTVWNLHTDVESWPSWQRPAAPMTIERLDPGPLRARSRFRATVDLPFPPTAQIVITSTVRQIRHHRCVRWTGPADGPGYHIDGTHVWTFTPTRTGVLVRTEETHTGPQADPNSDMGLDTWLADLKAAAEAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K4</accession>
    <name>A0A7W7T5K4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="181" mass="20314" checksum="8387394BDA75F98C" modified="2021-06-02" version="1">MTDQARPATVEELKALAHPLRWRVLRLCLDHALTNQELSARLGVAPATVLRHVRALTKAGFLVAEPVRTGNRGAVERPYRSTRRTWRLGLESVEGDLTRQVDLALISAHRAEVVEAGPDAYRDVARGVLRLDKAAQEELKARLYALIEEFTDRATPDGEPLSYLWSLNARPHHRESSTRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5K9</accession>
    <name>A0A7W7T5K9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_003059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4965700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4965700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="322" mass="35728" checksum="777DBDA430A8DA36" modified="2021-06-02" version="1">MTTVTETLGLTPDQTTDVLRAATLAPSVHNTQPWRFRLRPDRIELYPDLSRRLPATDPDDRELDLSCGAALFNLRLALRGHGVKPLVTLLPGSEAPGAAATIRLGGHRALDPETAELLDAIPHRRTNRKPFRDAAVPTTHRHALVRAAERERCWLHVVTRDERPRVQALMTKAYDLQIHDPRVDAELLTWTHDGIPPESRGHRPAGQDEWRFRDFRADDRPPGKDYEADPLVVVLCSFHDGRLAALQAGQALQRVLLTATAYGMSASFLSQVVEVAPVRDELRRALGGALIPQTVLRIGFGSPVPATPRRPVADLVHDDPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5L6</accession>
    <name>A0A7W7T5L6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding NarL/FixJ family response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4966716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="255"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4966716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="324" mass="35900" checksum="565F7CE47392002E" modified="2021-06-02" version="1">MPDPTALDLTSAEVDVYRELTDRAGTAAQLAARLRIGDDRVRTALRGLRRLDLVVRSSGRPAVFSAVAPAIGLGGLVLRRERKLEELRRLQTELQERHSRAVRGAEPTELLEVVGGTDGIARRAAQLMRSARHEVRFVDKPPYAEPPSILHPVERDLLDRGVRFRGVYDRDGLEMHGLEEDLEPGLALGEQARVVADAPLKMILVDRHSALIPLDSSAPDVRTALVVRPCTLLHALELLFENLWREALPLSLIDGEDLSAVDMRLLGLLTTGMPDRTIAKQLGLSYRTFQRRLHDLMEALGAQTRFQAGLRAAAKGWVRLSVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5R2</accession>
    <name>A0A7W7T5R2_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">F4559_004438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBB4967079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="95" mass="10973" checksum="210D71BD5674895C" modified="2021-06-02" version="1">MPELSRLPVPVTESWDWQLRGSCRGRDSSLFFHQPHERGSVRQEREARAKQICRQCPVLRECRAHALTVEETYGVWGGLGEGELRKLISRNHHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5S6</accession>
    <name>A0A7W7T5S6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_004467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="7">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4967108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="101" mass="10473" checksum="FABC900AA9EEDEFA" modified="2021-06-02" version="1">MTSAPEPDDNAAGPPPARVADQPVARHTRISGTWTAVLASIVVLTLLLVFILQNLTDATVHFLGGSSTLPLGVALLFAAIAGAILVALVGAARVLQLRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T5U5</accession>
    <name>A0A7W7T5U5_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_004497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4967138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="399" mass="41348" checksum="9AB5652516343469" modified="2021-06-02" version="1">MYVASVRPSERIKGRVPGTVLALGTVSLLTDVSAEMMTAFMPVYLLVTLNLNYAQFGVLDGLYTGATAVLRLVGGHLSDRTNRHKAVAAVGYGLSAVTKFLFPLAGTSAFGIGATMAADRAGKGLRSAPRDALISLATPPDRLGAAFGVHRTMDTIGALLGPLITFLLLQQIGIVAGPVFAVSGAFAIVGLIVLIAFVREHPKKPDRGPAPAIRAGLALLKDRKFRRVAIGTAVLGLATLSDAFVFILVQKATAVPLGLLPLMPLGTALIFLAAATPLGRLADRIGRWPVFLGGHVLLLAVYVMLLAPGSGYLGVGAALLLHGLFYAATDGVLSARVSPLVPETLRASGLAAVQTGQALARLVSSVAFGYLLEKATFHAAVLAAIAALVVSVLVAWRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T652</accession>
    <name>A0A7W7T652_9PSEU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
            <shortName evidence="3">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acpP</name>
        <name evidence="6" type="ORF">F4559_004647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 3 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3 4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4967288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="84" mass="9018" checksum="D4186237D45BD8B5" modified="2021-06-02" version="1">MSVEIVNAISTVIRELIPEYEGDIDLSSNFEEMGVDSLSRVDLVVALEREFSVTIPDSVLAELTTVGDLVAFVESAETAGSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6D7</accession>
    <name>A0A7W7T6D7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">F4559_004767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBB4967408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="195" mass="21213" checksum="D7C066928E9C7E14" modified="2021-06-02" version="1">MPKVIDHDQRRREIVEVAKKLIAEGGFEAATMRSIVTAAGFANGALKHYFDGKDGIIAATFQSVLQETERRVSTLDPGATPLEALHGFVEAAMPLDSHRITSARVLLVLWEHSVANPELARQYRELLTMWRAELTTRISAVLGDVPSDAPTVGVLADEIISVTIGANVASLMHPVGELVVRYNAYIDGLMKRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6K0</accession>
    <name>A0A7W7T6K0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_004865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4967506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="99" mass="10953" checksum="E4F4BA507B580AD2" modified="2021-06-02" version="1">MSGAYGPERVSGQGIAPENLPGEWAEAENVLTLREAHILAWRLRPRPGATDAAQLLFHRRAATLYRLVADKDAAHQHESLACATVEDNHAEKLTKTERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T6N3</accession>
    <name>A0A7W7T6N3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">F4559_004913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4967554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBB4967554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="100" mass="10908" checksum="5BA611CD8E6D8800" modified="2021-06-02" version="1">MGSSRPGGSPDDRFDDELIGLDPDDPETRAFAAHLDRMHREHPTFTVEGSLAGVEHFADSANRAGGLRRQTAVLIVLLILLGVGVSVWFYLGQILSVFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T7J6</accession>
    <name>A0A7W7T7J6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="266" mass="29967" checksum="08063CDE7B7C5008" modified="2021-06-02" version="1">MADPTEKERLDVVEPKVAELLATTERLTLELHRVSERVLVLERRLSGTGWSGDEDLDEIDDQVRDTVAALRSAWDAEQELLADSVRVELRQEVAEFDSLRERQEAGQRKLAAGRITRFERDTIDHEVNNLEWQIEVRTPSAAQAAARLQSDAIAGEESWRREAVIAGEKARQEIRDAARRRVEYTLGSYRRPPVWFTIGLGEVSTPDPTPWLRAAIGLVAYRLEYGVRSPVTPLGDPPSPASGSSAWVRRYNTYTDLNAQLAALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T860</accession>
    <name>A0A7W7T860_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pimeloyl-ACP methyl ester carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="291" mass="31006" checksum="4A5F64BD19B87D15" modified="2021-06-02" version="1">MYTQLSPHRAQRVDLPGRHGTIAALRAAASGRDLGATVLLLPGFTGSKEDFAPLVDPIADAGFEVVAVDLPGQYESAGSRLEGDYLPERLGADLVDVVGKLAAEGRRVLLVGHSYGGMVARGAVLAGAPTAGVTLMSTGPEALPPGDRRDALDLGETVLRAQGIEESQRLNEVRQAMNPRWASLPEELRDFYRTRFLRSSTAGLLGMGTGLRSEPDLVAKLSRKLRTSCVPCLVVCGEHDDAWSPASQRDMAERLDADFAVLPGVGHSPGTEAPDALLATLLPTWRAWLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T882</accession>
    <name>A0A7W7T882_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma-70 factor (ECF subfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_005694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="192" mass="21766" checksum="781E2B793C927664" modified="2021-06-02" version="1">MPTQQSTAAPTAPIESADWSPPTWDEVVREHADRVYRLAYRLTGNQHDAEDLTQETFIRVFRSLASYKPGTFEGWLHRITTNLFLDMARRRTRLRMEGLPEDTDRLAGDDPSPEQVWSDTHLDPDLQAALDELPPEFRAAVVLCDVEGLSYEEIGATLGVKLGTVRSRIHRGRQALRASLERRRGLVQEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T885</accession>
    <name>A0A7W7T885_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase/pyrazinamidase</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
            <ecNumber evidence="2">3.5.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EC" id="3.5.1.19" evidence="2"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="189" mass="19156" checksum="849D1D82C0648936" modified="2021-06-02" version="1">MTKALIVVDVQNDFCEGGSLAVTGGAAVAAAISAHVAAGGYDHVVATRDYHVDPGDHFSENPDYVDSWPVHCVAGSAGASFHPEFDVTPVEAVFSKGAYAAAYSGFEGASGAGEALTDWLRAHGVDEVDVVGIATDHCVRATAVDAARAGFATRVLLDLTAGVARTTVDTALETLGAAGVVLEGTPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8C4</accession>
    <name>A0A7W7T8C4_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="150" mass="17086" checksum="C138316C612EC85E" modified="2021-06-02" version="1">MDGIPDNPDQLRGRLPFRELIGDPFDPARRAIIPAITTLTIRLRRHPAEPSFLLHWRDPAKVATAGGVYDVIPAGEFQPSSVALWDRRNDFGLWRNIVREYPEELLGEPEHDGTRTQPIDYDNWHLYRALGEARAAGKLGSFFWASAWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N0</accession>
    <name>A0A7W7T8N0_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding transcriptional MerR regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="98" mass="10848" checksum="4D5E0EEEEC3D78E8" modified="2021-06-02" version="1">MAEYLLAHPVRLSLDTVAARSGLHPELLRRFVALSLVDGTADSSGRLWFAPSAVAALARIQRLRTGLCLNYAAIGLVLDLLDRIDVLEAQVRSHRRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8N3</accession>
    <name>A0A7W7T8N3_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative UBP type Zn finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_005963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBP-type" evidence="1">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="87" mass="9733" checksum="F8389CD022323BA5" modified="2021-06-02" version="1">MTGAVDRHLALVRDVVPRTPQGCEECLIAGTPWLHLRLCLTCGHVGCCDSSPMKHAGKHAHAIVHPIVRSFEPGETWRWCYVDRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="2" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8R7</accession>
    <name>A0A7W7T8R7_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">F4559_005426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="MBB4968067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="165" mass="16927" checksum="1F673A3618FFF6AE" modified="2021-06-02" version="1">MTTAKYESTLDIGPTTYRLLATADPDVVVELTGVDRAGARVAEGVLRLPASGGGPVGKVLAQVLEALTRLGAPPTTRRPANANQPWTAERDEELRAAWLAADPGAAAGGLVREIAKRLERSASAIRARLAKVGCDPDVPGRVLSGQGAALLGVQGPDQGSAQGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8T9</accession>
    <name>A0A7W7T8T9_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">F4559_006051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">DSM 45084</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBB4968692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="83" mass="9079" checksum="CE84ADFC289E4B2E" modified="2021-06-02" version="1">MSPVRRGTMRPIHNRIAALRAERGLSRAGLADAVEVNPQTIGALERGDHYPSLDLALRICEVFGLPVEAVFGRMPFGRASTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8X6</accession>
    <name>A0A7W7T8X6_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
            <ecNumber evidence="7">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">F4559_006112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="7"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="6">
        <location>
            <begin position="92"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="5">
        <location>
            <begin position="237"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBB4968753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="462" mass="48191" checksum="ADF08037CF06A2FA" modified="2021-06-02" version="1">MPVPGPGYSITVRLESPPSASAAGDLTSAVGRAGGVITAFDVVESHADRVIIDLTCNALSANHAKDITDTLGQLPGIVVRKVSDRTFLVHLGGKIEISSKVPLRNRDDLSRAYTPGVARVCQAIAENPDDARRLTIKRNTVAVVTDGSAVLGLGNLGPAAALPVMEGKAALFKKFAGVDAWPVCLDTQDTEEIIRAVELIAPVYGGINLEDIAAPRCFEIEARLRDKLDIPVFHDDQHGTAIVVVGALRNALRVVGKKPADCKIVVCGVGAAGSAIIRLLLKQEPGDVVAVDVDGIVHRDRPGLDDNLRSIAAATNRDNVSGTLHEALVGADVFIGVSAPNLLGAEQVATMNEKAIVFALANPDPEIDPMEAQKHAAVVATGRSDFPNQINNVLAFPGVFRGLLDANAKTITDAMLLAAANAIADVVDGDRINASFIVPSVFDTSVAPAVAEAVRKAATGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T8Z1</accession>
    <name>A0A7W7T8Z1_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="6">4.1.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">F4559_006054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">DSM 45084</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA photolyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="6"/>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="PTHR11455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="SSF48173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="SSF52425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="5">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBB4968695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000542674"/>
        </source>
    </evidence>
    <sequence length="422" mass="48460" checksum="3FE8347CDF57CEEC" modified="2021-06-02" version="1">MDSSTVVWFRRDLRVTDHPALLEAAGRADRALGLFVLDPRLLEASGQPRVEFLHRCLRTLDEKLGGRLMIAVGDPVDVVPRVARSVGAESVHVSADFGPYGRERDEAVGEKVELVRVGSPYAVAPGRVLKNDGTPYRVFTPFSRAWREHGWRAPANTNKSTVDWMTPEKTERLPEGDGLPDVTRLWRTFRDERLPDYADHRDRPDLDRTSRFSAFLKWGVVHPRTLLADLGSDEGSKAFRNELAWREFYADVLWHNPSSARENLDKRFDRIHLDDDRERFAAWCEGRTGYPFVDAGMRQLLAEGWMHNRVRMVVASFLVKDLHLPWWWGARHFMRHLVDGDLASNQHNWQWAAGSGTDAAPYFRIFNPVTQGEKFDPDGTYVRRYVPELRDVKGKQVHRPTDPIVDHAHERQEALARFGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7W7T988</accession>
    <name>A0A7W7T988_9PSEU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tight adherence protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">F4559_006282</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Saccharothrix violaceirubra</name>
        <dbReference type="NCBI Taxonomy" id="413306"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Pseudonocardiales</taxon>
            <taxon>Pseudonocardiaceae</taxon>
            <taxon>Saccharothrix</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-08" db="EMBL/GenBank/DDBJ databases">
            <title>Sequencing the genomes of 1000 actinobacteria strains.</title>
            <authorList>
                <person name="Klenk H.-P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">DSM 45084</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="JACHJS010000001">
        <property type="protein sequence ID" value="MBB4968923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000542674">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBB4968923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP00
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